title: Effects of different anaesthetics on cytokine levels in children with community-acquired pneumonia undergoing flexible fibreoptic bronchoscopy.
abstract: OBJECTIVE
  To determine the effects of propofol and sevoflurane on cytokine levels in children with community-acquired pneumonia undergoing flexible fibreoptic bronchoscopy (FFB).
  
  
  METHODS
  Children with community-acquired pneumonia were randomly assigned to receive 3-5 mg/kg propofol i.v. or 8% inhaled sevoflurane. Haemodynamic variables, stress hormone responses and serum cytokines were compared between the two groups.
  
  
  RESULTS
  Out of 50 children aged 2-12 years (propofol, n = 25; sevoflurane, n = 25), there were no significant between-group differences in haemodynamic variables and stress hormones. Interleukin (IL)-6 and IL-10 decreased significantly following FFB in both groups. IL-6 levels were significantly lower in the sevoflurane group than propofol group at 4 h and 1 d following FFB (61.3 ± 11.9 versus 82.6 ± 19.7 pg/ml; 52.8 ± 9.7 versus 75.4 ± 13.6 pg/ml, respectively). IL-10 levels in the sevoflurane group were significantly lower than in the propofol group at 1 d following FFB.
  
  
  CONCLUSIONS
  In children with community-acquired pneumonia, use of sevoflurane was associated with lower circulating IL-6 and IL-10 levels compared with propofol, following FFB. Pneumonia severity is reflected by higher blood cytokine levels, thus, sevoflurane may be more beneficial to recovery from community-acquired pneumonia than propofol, however further studies are required to test this hypothesis.
authors.affiliation: Department of Anaesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, China Department of Anaesthesiology, Hubei Maternal and Child Health Hospital, Wuhan, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Anaesthesiology, Hubei Maternal and Child Health Hospital, Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Anaesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, China znyywyl@hotmail.com.
authors.forename: Yan-Lin
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D001999:Bronchoscopy; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000097:blood* / Q000503:physiopathology; D016207:Cytokines / Q000097:blood*; D003710:Demography; D005260:Female; D005336:Fiber Optic Technology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011014:Pneumonia / Q000097:blood* / Q000503:physiopathology; D015742:Propofol / Q000494:pharmacology; D000077208:Remifentanil; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D016207:Cytokines; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D000077208:Remifentanil; D015742:Propofol
keywords: Bronchoscopy; cytokines; physiological; propofol; sevoflurane; stress