title: Role of the monocarboxylate transporter MCT1 in the uptake of lactate during active recovery.
abstract: OBJECTIVE
  We assessed the role of monocarboxylate transporter 1 (MCT1) on lactate clearance during an active recovery after high-intensity exercise, by comparing genetic groups based on the T1470A (rs1049434) MCT1 polymorphism, whose influence on lactate transport has been proven.
  
  
  METHODS
  Sixteen young male elite field hockey players participated in this study. All of them completed two 400 m maximal run tests performed on different days, followed by 40 min of active or passive recovery. Lactate samples were measured immediately after the tests, and at min 10, 20, 30 and 40 of the recoveries. Blood lactate decreases were calculated for each 10-min period. Participants were distributed into three groups according to the T1470A polymorphism (TT, TA and AA).
  
  
  RESULTS
  TT group had a lower blood lactate decrease than AA group during the 10-20 min period of the active recovery (p = 0.018). This period had the highest blood lactate for the whole sample, significantly differing from the other periods (p ≤ 0.003). During the passive recovery, lactate declines were constant except for the 0-10-min period (p ≤ 0.003), suggesting that liver uptake is similar in all the genetic groups, and that the difference seen during the active recovery is mainly due to muscle lactate uptake.
  
  
  CONCLUSIONS
  These differences according to the polymorphic variant T1470A suggest that MCT1 affects the plasma lactate decrease during a crucial period of active recovery, where the maximal lactate amount is cleared (i.e. 10-20 min period).
authors.affiliation: LFE Research Group, Faculty of Physical Activity and Sports Sciences-INEF, Universidad Politécnica de Madrid, C/Martín Fierro no 7, 28040, Madrid, Spain. rocio.cupeiro@upm.es.
authors.forename: Rocío
authors.initials: R
authors.lastname: Cupeiro
authors.affiliation: Laboratory of Pediatrics, Facultad de Medicina, Universidad de Cantabria, Avda. Cardenal Herrera Oria s/n, 39011, Santander, Cantabria, Spain.
authors.forename: Raúl
authors.initials: R
authors.lastname: Pérez-Prieto
authors.affiliation: Laboratory of Pediatrics, Facultad de Medicina, Universidad de Cantabria, Avda. Cardenal Herrera Oria s/n, 39011, Santander, Cantabria, Spain.|Division of Pediatrics, Valdecilla Research Institute (IDIVAL), Edificio IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011, Santander, Cantabria, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Amigo
authors.affiliation: Division of Pediatrics, Valdecilla Research Institute (IDIVAL), Edificio IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011, Santander, Cantabria, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Gortázar
authors.affiliation: Laboratory of Pediatrics, Facultad de Medicina, Universidad de Cantabria, Avda. Cardenal Herrera Oria s/n, 39011, Santander, Cantabria, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Redondo
authors.affiliation: Laboratory of Pediatrics, Facultad de Medicina, Universidad de Cantabria, Avda. Cardenal Herrera Oria s/n, 39011, Santander, Cantabria, Spain.|Division of Pediatrics, Valdecilla Research Institute (IDIVAL), Edificio IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011, Santander, Cantabria, Spain.
authors.forename: Domingo
authors.initials: D
authors.lastname: González-Lamuño
mesh_terms: D000328:Adult; D001692:Biological Transport / Q000235:genetics / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006688:Hockey; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000235:genetics*; D009132:Muscles / Q000378:metabolism; D010807:Physical Endurance / Q000235:genetics* / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000235:genetics; D027981:Symporters / Q000235:genetics*; D055815:Young Adult; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D019344:Lactic Acid; D027501:Monocarboxylic Acid Transporters; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1
keywords: Active recovery; Lactate clearance; Monocarboxylate transporters