title: Lens epithelial cell growth on the anterior optic of 2 hydrophobic intraocular lens models.
abstract: OBJECTIVE
  To evaluate lens epithelial cell (LEC) proliferation on the anterior optic of 2 types of hydrophobic intraocular lenses (IOLs).
  
  
  METHODS
  Harlan Biotech Israel and Kaplan Medical Center, Rehovot, Israel.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Ten New Zealand white rabbits had crystalline lens removal and implantation of an Acrysof IOL in 1 eye (Group 1) and a Tecnis IOL in the fellow eye (Group 2). A weekly biomicroscopy examination was performed during the 2-week study duration, after which the rabbits were humanely killed. The eyes were enucleated, and the complexes containing the IOL and the capsular bag were evaluated for the presence of LECs and large cells (macrophages and giant cells) on the IOL anterior optic and for proteinaceous matrix deposits along the capsulorhexis margin.
  
  
  RESULTS
  Lens epithelial cell were detected on all of the IOLs in Group 1 and on none in Group 2 (P < .001). Areas of proteinaceous matrix deposits adjacent to the edge of the capsulorhexis were detected on 8 IOLs in Group 1 and on none in Group 2 (P < .001). Large cells were identified on all IOLs in Group 1 and on 9 IOLs in Group 2 (P = 1.0). No difference in the general inflammation markers was found between the 2 IOL types (P = .234).
  
  
  CONCLUSIONS
  Lens epithelial cell with corresponding proteinaceous matrix deposits were significantly more abundant on the IOLs in Group 1 than on the IOLs in Group 2. There was no difference in the presence of large cells or in general inflammation markers between the 2 IOL types.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Department of Ophthalmology (Weinberg, Kleinmann) and the Department of Pathology (Huszar, Harari), Kaplan Medical Center, and Harlan Biotech Laboratories (Klein, Ezov), Rehovot, and the Department of Ophthalmology (Zadok), Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Tamir
authors.initials: T
authors.lastname: Weinberg
authors.affiliation: From the Department of Ophthalmology (Weinberg, Kleinmann) and the Department of Pathology (Huszar, Harari), Kaplan Medical Center, and Harlan Biotech Laboratories (Klein, Ezov), Rehovot, and the Department of Ophthalmology (Zadok), Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Ido
authors.initials: I
authors.lastname: Klein
authors.affiliation: From the Department of Ophthalmology (Weinberg, Kleinmann) and the Department of Pathology (Huszar, Harari), Kaplan Medical Center, and Harlan Biotech Laboratories (Klein, Ezov), Rehovot, and the Department of Ophthalmology (Zadok), Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Zadok
authors.affiliation: From the Department of Ophthalmology (Weinberg, Kleinmann) and the Department of Pathology (Huszar, Harari), Kaplan Medical Center, and Harlan Biotech Laboratories (Klein, Ezov), Rehovot, and the Department of Ophthalmology (Zadok), Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Monica
authors.initials: M
authors.lastname: Huszar
authors.affiliation: From the Department of Ophthalmology (Weinberg, Kleinmann) and the Department of Pathology (Huszar, Harari), Kaplan Medical Center, and Harlan Biotech Laboratories (Klein, Ezov), Rehovot, and the Department of Ophthalmology (Zadok), Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Harari
authors.affiliation: From the Department of Ophthalmology (Weinberg, Kleinmann) and the Department of Pathology (Huszar, Harari), Kaplan Medical Center, and Harlan Biotech Laboratories (Klein, Ezov), Rehovot, and the Department of Ophthalmology (Zadok), Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Nathan
authors.initials: N
authors.lastname: Ezov
authors.affiliation: From the Department of Ophthalmology (Weinberg, Kleinmann) and the Department of Pathology (Huszar, Harari), Kaplan Medical Center, and Harlan Biotech Laboratories (Klein, Ezov), Rehovot, and the Department of Ophthalmology (Zadok), Assaf Harofeh Medical Center, Zerifin, Israel. Electronic address: guy.kleinmann@hsc.utah.edu.
authors.forename: Guy
authors.initials: G
authors.lastname: Kleinmann
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D019923:Capsulorhexis; D049109:Cell Proliferation; D003459:Crystallins / Q000378:metabolism; D004847:Epithelial Cells / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology; D057927:Hydrophobic and Hydrophilic Interactions; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000473:pathology* / Q000601:surgery; D007910:Lenses, Intraocular; D008264:Macrophages / Q000473:pathology; D008297:Male; D011485:Protein Binding / Q000502:physiology; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D003459:Crystallins