title: Two-Year Safety and Efficacy of Biodegradable Polymer Drug-Eluting Stent Versus Second-Generation Durable Polymer Drug-Eluting Stent in Patients With Acute Myocardial Infarction: Data from the Korea Acute Myocardial Infarction Registry (KAMIR).
abstract: BACKGROUND
  Despite improved long-term safety of biodegradable polymer (BP) drug-eluting stents (DES) compared to first-generation durable polymer (DP) DES, data on the safety and efficacy of BP-DES compared with second-generation (2G) DP-DES in patients with acute myocardial infarction (AMI) are limited.
  
  
  OBJECTIVE
  To evaluate the safety and efficacy of BP-DES compared with 2G-DP-DES in the higher stent thrombosis (ST) risk setting of AMI.
  
  
  METHODS
  A total of 3359 AMI patients who received either BP-DES (n = 261) or 2G-DP-DES (n = 3098) were included from the Korea Acute Myocardial Infarction Registry (KAMIR). Differences in baseline clinical and angiographic characteristics were adjusted using a 1:5 propensity score matching analysis (n = 261 for BP-DES and n = 1305 for 2G-DP-DES). The primary outcome was the incidence of major adverse cardiac events (MACE) including all-cause death, recurrent myocardial infarction (re-MI), and target vessel revascularization (TVR). The rate of definite or probable ST was also investigated.
  
  
  RESULTS
  In adjusted analysis, there was no significant difference between the 2 groups in baseline clinical and angiographic characteristics; 2-year MACE (10.7% and 9.9% in the BP-DES group and 2G-DP-DES group, respectively, P = 0.679); ST incidence (0.8% vs 0.9%, respectively, P = 1.0), and rates of all-cause death, re-MI, and TVR. By multivariate analysis, old age, diabetes mellitus, renal dysfunction, and left ventricular dysfunction were the independent predictors of MACE after BP-DES or 2G-DP-DES implantation.
  
  
  CONCLUSIONS
  BP-DES and 2G-DP-DES appear to have comparable 2-year safety and efficacy for the treatment of AMI. However, longer-term follow-up is needed.
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South Korea.
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Hur
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South Korea.
authors.forename: In-Cheol
authors.initials: IC
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South Korea.
authors.forename: Ki-Bum
authors.initials: KB
authors.lastname: Won
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South Korea.
authors.forename: Yun-Kyeong
authors.initials: YK
authors.lastname: Cho
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South Korea.
authors.forename: Hyuck-Jun
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South Korea.
authors.forename: Chang-Wook
authors.initials: CW
authors.lastname: Nam
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South Korea.
authors.forename: Kwon-Bae
authors.initials: KB
authors.lastname: Kim
authors.affiliation: Department of Statistics, Keimyung University, Daegu, South Korea.
authors.forename: Min-Seok
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Statistics, Keimyung University, Daegu, South Korea.
authors.forename: Jincheol
authors.initials: J
authors.lastname: Park
authors.affiliation: Division of Cardiology, Korea University Guro Hospital, Seoul, South Korea.
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.affiliation: Division of Cardiology, Kyungpook National University Hospital, Daegu, South Korea.
authors.forename: Shung-Chull
authors.initials: SC
authors.lastname: Chae
authors.affiliation: Division of Cardiology, Yeungnam University Hospital, Daegu, South Korea.
authors.forename: Young-Jo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Kyung Hee University Hospital, Seoul, South Korea.
authors.forename: Chong-Jin
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Chungbuk National University Hospital, Cheongju, South Korea.
authors.forename: Myeong-Chan
authors.initials: MC
authors.lastname: Cho
authors.affiliation: Division of Cardiology, Chonnam National University Hospital, Gwangju, South Korea.
authors.forename: Myung-Ho
authors.initials: MH
authors.lastname: Jeong
authors.affiliation: Division of Cardiology, Chonnam National University Hospital, Gwangju, South Korea.
authors.forename: Young-Keun
authors.initials: YK
authors.lastname: Ahn
authors.affiliation: Division of Cardiology, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Hyo-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Gachon University Gil Hospital, Inchon, South Korea.
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Ahn
authors.affiliation: Division of Cardiology, Catholic University Hospital, Seoul, South Korea.
authors.forename: Ki-Bae
authors.initials: KB
authors.lastname: Seung
authors.affiliation: Division of Cardiology, Yonsei University Severance Hospital, Seoul, South Korea.
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.affiliation: Division of Cardiology, Yonsei University Wonju Hospital, Wonju, South Korea.
authors.forename: Jung-Han
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Division of Cardiology, Chungnam National University Hospital, Daejeon, South Korea.
authors.forename: In-Whan
authors.initials: IW
authors.lastname: Seong
authors.affiliation: Division of Cardiology, Busan National University Hospital, Busan, South Korea.
authors.forename: Taek-Jong
authors.initials: TJ
authors.lastname: Hong
authors.affiliation: Division of Cardiology, Konyang University Hospital, Daejeon, South Korea.
authors.forename: Jang-Ho
authors.initials: JH
authors.lastname: Bae
authors.affiliation: Division of Cardiology, Ulsan University Asan Medical Center, Seoul, South Korea.
authors.forename: Seung-Jung
authors.initials: SJ
authors.lastname: Park
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000209:etiology; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D011108:Polymers; D057216:Propensity Score; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011474:Prosthesis Design; D012008:Recurrence; D012042:Registries; D056910:Republic of Korea; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011108:Polymers