title: Vertical Transmission of Histoplasmosis Associated With Anti-Tumor Necrosis Factor Therapy.
abstract: Therapeutics blocking the activity of tumor necrosis factor (anti-TNF) are a risk factor for invasive fungal infections; however, infectious risks to infants born to mothers receiving anti-TNF therapy are not well defined. We report a case of vertical transmission of disseminated histoplasmosis in a mother-infant pair exposed to anti-TNF therapy.
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics.
authors.forename: James G
authors.initials: JG
authors.lastname: Carlucci
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics.
authors.forename: Natasha
authors.initials: N
authors.lastname: Halasa
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics.
authors.forename: C Buddy
authors.initials: CB
authors.lastname: Creech
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Dulek
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics.
authors.forename: Oscar G
authors.initials: OG
authors.lastname: Gómez-Duarte
authors.affiliation: Division of Infectious Diseases.
authors.forename: George E
authors.initials: GE
authors.lastname: Nelson
authors.affiliation: Division of Infectious Diseases.
authors.forename: H Keipp
authors.initials: HK
authors.lastname: Talbot
authors.affiliation: Department of Internal Medicine.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Scalise
authors.affiliation: Tennessee Maternal Fetal Medicine, Nashville.
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Scott
authors.affiliation: Division of Gastroenterology, Department of Medicine, UCSF Medical Center, San Francisco, California.
authors.forename: Uma
authors.initials: U
authors.lastname: Mahadevan
authors.affiliation: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine.
authors.forename: Dawn B
authors.initials: DB
authors.lastname: Beaulieu
mesh_terms: D000328:Adult; D005260:Female; D006660:Histoplasmosis / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D000069285:Infliximab / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab
keywords: histoplasmosis; immunocompromised host; infant; tumor necrosis factor; vertical transmission