title: A bug's view of allergic airways disease.
abstract: The increase in allergic airways disease has been linked to modern urbanization and lifestyle. Recent evidence suggests that the associated reduction in microbial exposure, reduction in dietary fibre intake and increased antibiotic use may cause early dysbiosis in infancy, which predisposes to immune dysregulation and allergic airways disease later in life. This implies that there may be a window of opportunity for primary prevention strategies aimed to protect or restore the microbiome early in life and thereby decrease the risk of developing allergic airways disease. Alternatively, strategies that correct dysbiosis may aid in the treatment of established allergic airways disease.
authors.affiliation: Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney. Electronic address: peter.hsu@health.nsw.gov.au.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Hsu
authors.affiliation: Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney.
authors.forename: Dianne E
authors.initials: DE
authors.lastname: Campbell
mesh_terms: D064806:Dysbiosis / Q000276:immunology* / Q000382:microbiology* / Q000517:prevention & control; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000382:microbiology* / Q000517:prevention & control; D064307:Microbiota; D011322:Primary Prevention; D012140:Respiratory Tract Diseases / Q000276:immunology* / Q000382:microbiology* / Q000517:prevention & control; D012307:Risk Factors
keywords: Allergic airways disease; Dysbiosis; Microbiome; Prebiotic; Probiotic