title: [ix-layer structure for genomics:A powerful conceptual framework that integrates research, test and treatment].
abstract: Genomic data are now available from various fields of medicine and biology, and I proposed a conceptual framework "Six-layer structure" to integrate various areas of genomics. The proposed layers are "life" as the uppermost layer, followed by "species","population","family","individual",and finally "cell" as the bottommost layer. In each pair of adjacent layers, each member of the upper layer comprises a set of members of the lower layer. In each layer, we can define consistent partial orders of members based on genomic data in the forms of phylogenic and pedigree trees. Based on this framework, we can give integrated explanations for various researches, tests and drug therapies concerning genomic data, and we can use this framework for new discoveries as well as new test and drug developments.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
mesh_terms: D055106:Genome-Wide Association Study; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans