title: Effects of tumor necrosis factor α inhibitors extend beyond psoriasis: insulin sensitivity in psoriasis patients with type 2 diabetes mellitus.
abstract: Psoriasis is a chronic inflammatory disease that has been associated with an increased incidence of insulin resistance and diabetes mellitus (DM). Tumor necrosis factor (TNF) α inhibitors and IL-6 blockers, which are routinely used for the treatment of psoriasis, have been positively associated with insulin sensitivity. The aim of this study was to assess the effects of treatment with TNF-α inhibitors on insulin sensitivity in psoriatic patients with type 2 DM. This study confirms a beneficial effect of anti-TNF-α agents on insulin resistance and insulin sensitivity in psoriasis patients with type 2 DM.
authors.affiliation: Department of Medicine, Kuwait University, Kuwait City.
authors.forename: Nawaf
authors.initials: N
authors.lastname: Al-Mutairi
authors.affiliation: Department of Dermatology, Farwaniya Hospital, Kuwait City.
authors.forename: Dalia
authors.initials: D
authors.lastname: Shabaan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D014409:Tumor Necrosis Factor-alpha