title: ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress.
abstract: A previous study found that the antidepressant-like effects of ethanolic extracts from Hemerocallis citrina are predominantly related to the flavonoid, hesperidin. The study herein aimed to explore the antidepressant-like mechanism of hesperidin in mice induced by chronic mild stress (CMS). The results indicated that hesperidin reversed the reduction of sucrose preference and the elevation of immobility time in mice induced by CMS. In addition, the increase in serum corticosterone levels and decrease in hippocampal extracellular signal-regulated kinase (ERK) phosphorylation and brain-derived neurotrophic factor (BDNF) levels in CMS mice were also ameliorated by hesperidin treatment. In contrast, improvement by hesperidin was suppressed by pretreatment with ERK inhibitor SL327. Taken together, our findings confirmed the antidepressant-like effect of hesperidin and indicated that hesperidin-induced BDNF up-regulation was mediated in an ERK-dependent manner.
authors.affiliation: Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China. Electronic address: lichengfu103@126.com.
authors.forename: Cheng-Fu
authors.initials: CF
authors.lastname: Li
authors.affiliation: Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China.
authors.forename: Shao-Mei
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Chen
authors.affiliation: Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
authors.forename: Rong-Hao
authors.initials: RH
authors.lastname: Mu
authors.affiliation: Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
authors.forename: Shuang-Shuang
authors.initials: SS
authors.lastname: Wang
authors.affiliation: Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Geng
authors.affiliation: Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China. Electronic address: litao.yi@yahoo.com.
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Yi
mesh_terms: D000607:Aminoacetonitrile / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D005508:Food Deprivation; D005518:Food Preferences / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D006569:Hesperidin / Q000494:pharmacology / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010766:Phosphorylation / Q000187:drug effects; D011480:Protease Inhibitors / Q000494:pharmacology; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy*; D013395:Sucrose / Q000008:administration & dosage
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D011480:Protease Inhibitors; C424127:SL 327; D000607:Aminoacetonitrile; D013395:Sucrose; D006569:Hesperidin; D048049:Extracellular Signal-Regulated MAP Kinases; D003345:Corticosterone
keywords: Antidepressant; Brain-derived neurotrophic factor; Chronic mild stress; Corticosterone; Hemerocallis citrina; Hesperidin