title: Association of ACE Gene I/D polymorphism with migraine in Kashmiri population.
abstract: BACKGROUND
  Migraine is a complex, recurrent headache disorder that is one of the most common complaints in neurology practice. The role of various genes in its pathogenesis is being studied. We did this study to see whether an association exists between ACE gene I/D polymorphism and migraine in our region.
  
  
  METHODS
  The study included 100 patients diagnosed with migraine and 121 healthy controls. The study subject were age and gender matched. The analysis was based on Polymerase Chain Reaction (PCR) and included following steps: DNA extraction from blood, PCR and Restriction Fragment Length Polymorphism (RFLP).
  
  
  RESULTS
  Out of 100 cases, 69 were females and 31 were males. Fifty-seven were having migraine without aura and 43 had migraine with aura. 45 of the cases had II polymorphism, 40 had ID polymorphism and 15 had DD polymorphism in ACE gene.
  
  
  CONCLUSIONS
  We were not able to find a statistically significant association between ACE gene I/D polymorphism with migraine. The reason for difference in results between our study and other studies could be because of different ethnicity in study populations. So a continuous research is needed in this regard in order to find the genes and different polymorphism that increase the susceptibility of Kashmiri population to migraine.
authors.affiliation: Department of Neurology, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Irfan Yousuf
authors.initials: IY
authors.lastname: Wani
authors.affiliation: Department of Neurology, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Saleem
authors.initials: S
authors.lastname: Sheikh
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Zafar Amin
authors.initials: ZA
authors.lastname: Shah
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Arshid A
authors.initials: AA
authors.lastname: Pandith
authors.affiliation: Department of Neurology, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Mushtaq
authors.initials: M
authors.lastname: Wani
authors.affiliation: Department of Neurology, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Ravouf
authors.initials: R
authors.lastname: Asimi
authors.affiliation: Department of Neurology, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Maqbool
authors.initials: M
authors.lastname: Wani
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Shahnawaz
authors.initials: S
authors.lastname: Sheikh
authors.affiliation: Department of Neurology, Sher-i-Kashmir Institute of Medical Sciences Medical College, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Iqra
authors.initials: I
authors.lastname: Mehraj
keywords: ACE gene; gene polymorphism; migraine