title: Prospective Study of Dietary Phytoestrogen Intake and the Risk of Colorectal Cancer.
abstract: Dietary phytoestrogen intake has been inversely associated with the risk of prostate and breast cancer and might also affect the risk of colorectal cancer. We evaluated the associations between dietary lignan intake, dietary isoflavonoid intake, dietary coumestrol intake, and dietary enterolignans and equol intake, and risk of colorectal cancer. Data from the Women's Lifestyle and Health (WLH) Cohort study was used. The WLH study is a prospective population-based cohort study including 48,268 Swedish women aged 30-49 years at the time of enrolment in 1991-92. Follow-up for colorectal cancer incidence, death, and emigration until the end of 2010 was performed through record linkage to the Swedish Cancer Registry and Total Population Register. During follow-up 206 incident colorectal cancer cases were identified. Cox proportional hazards models were fitted to estimate adjusted risk ratios with 95% confidence intervals. We found no statistically significant association between the intake of dietary lignans, dietary isoflavonoids, coumestrol, or enterolignans and equol, and risk of colorectal cancer. We found no association between dietary phytoestrogen intake and the risk of colorectal cancer. However, since the number of cancer cases was small, our results need to be confirmed. Future studies should investigate colon and rectal cancer separately.
authors.affiliation: a Division of Oncology, Department of Clinical Sciences, the Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.|b Unit of Clinical Cancer Epidemiology, Department of Oncology and Pathology , Karolinska Institutet , Stockholm , Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Hedelin
authors.affiliation: c Department of Biosciences and Nutrition , Karolinska Institutet , Stockholm , Sweden.|d Department of Clinical and Experimental Medicine , University of Linköping , Linköping , Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Löf
authors.affiliation: e Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
authors.forename: Sven
authors.initials: S
authors.lastname: Sandin
authors.affiliation: e Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.|f Department of Epidemiology , Harvard School of Public Health , Boston , Massachusetts , USA.
authors.forename: Hans-Olov
authors.initials: HO
authors.lastname: Adami
authors.affiliation: e Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.|g Department of Research , Cancer Registry of Norway , Oslo , Norway.|h Department of Community Medicine , Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway , Tromsø , Norway.|i Folkhälsan Research Center , Helsinki , Finland.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Weiderpass
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D004032:Diet; D005260:Female; D006801:Humans; D008875:Middle Aged; D048789:Phytoestrogens / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
chemical_list: D048789:Phytoestrogens