title: Rational design of fiber forming supramolecular structures.
abstract: Recent strides in the development of multifunctional synthetic biomimetic materials through the self-assembly of multi-domain peptides and proteins over the past decade have been realized. Such engineered systems have wide-ranging application in bioengineering and medicine. This review focuses on fundamental fiber forming α-helical coiled-coil peptides, peptide amphiphiles, and amyloid-based self-assembling peptides; followed by higher order collagen- and elastin-mimetic peptides with an emphasis on chemical / biological characterization and biomimicry.
authors.affiliation: Rice University, Houston, TX 77030, USA vak1@rice.edu.
authors.forename: Vivek A
authors.initials: VA
authors.lastname: Kumar
authors.affiliation: Rice University, Houston, TX 77030, USA.
authors.forename: Benjamin K
authors.initials: BK
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Satoko M
authors.initials: SM
authors.lastname: Kanahara
mesh_terms: D000682:Amyloid / Q000737:chemistry; D000818:Animals; D040761:Biomimetic Materials; D003094:Collagen / Q000737:chemistry; D004549:Elastin / Q000737:chemistry; D006801:Humans; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D000682:Amyloid; D010455:Peptides; D003094:Collagen; D004549:Elastin
keywords: Tissue engineering; elastin-mimetic peptides; peptide amphiphiles; peptide chemistry; supramolecular chemistry