title: Brief Report: L-Selectin (CD62L) Is Downregulated on CD4+ and CD8+ T Lymphocytes of HIV-1-Infected Individuals Naive for ART.
abstract: The expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here, we measured CD62L expression on T-cell subsets of HIV-1-infected individuals naive for antiretroviral therapy (ART-naive) or receiving therapy (ART), and seronegative control subjects (HIV-neg). We found reduced frequencies of CD62L(+) cells among CD4(+) and CD8(+) T cells from ART-naive as compared with ART and HIV-neg groups, particularly within naive and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased after ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared with HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8(+) T cells, but not in CD4(+) T cells. We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.
authors.affiliation: *Laboratory of Immunoinfectivology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; and †Department of Medicine of Systems, Tor Vergata University, Rome, Italy.
authors.forename: Lia
authors.initials: L
authors.lastname: Vassena
authors.forename: Erica
authors.initials: E
authors.lastname: Giuliani
authors.forename: Anna R
authors.initials: AR
authors.lastname: Buonomini
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Malagnino
authors.forename: Massimo
authors.initials: M
authors.lastname: Andreoni
authors.forename: Margherita
authors.initials: M
authors.lastname: Doria
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D018450:Disease Progression; D015536:Down-Regulation; D020869:Gene Expression Profiling; D015658:HIV Infections / Q000276:immunology* / Q000378:metabolism*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D019041:L-Selectin / Q000378:metabolism*; D008213:Lymphocyte Activation; D020239:Receptor Cross-Talk; D019562:Viral Load; D014779:Virus Replication
chemical_list: D019041:L-Selectin