title: Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography.
abstract: The aim of the present study was to investigate the association between serum lumican levels and acute aortic dissection (AAD) severity. A total of 82 patients with chest or back pain and 30 healthy volunteers were recruited. Among the patients, there were 70 cases of AAD and 12 cases of intramural hematoma (IMH). AAD severity was determined using multi-slice computed tomography angiography (MSCTA). Serum was collected from the patients upon admission, and lumican levels were detected using an enzyme-linked immunosorbent assay. In addition, correlation analyses were conducted between lumican levels and AAD severity by designing a 'SCORE X, RANGE Y' system to measure the number of affected vital arteries and vertical range of false lumen, based on the MSCTA. Lumican levels differed significantly among the AAD patients (2.32±4.29 ng/ml), IMH patients (0.72±0.32 ng/ml) and healthy volunteers (0.85±0.53 ng/ml; P=0.003). In the AAD patients presenting within 12-72 h of symptom onset, the Spearman's rho correlation coefficient between lumican and SCORE or RANGE was 0.373 (P=0.046) and 0.468 (P=0.010), respectively. The present results suggest that lumican may be a potential marker for aiding the diagnosis and screening for AAD, and may be used to predict the severity of AAD.
authors.affiliation: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Guorong
authors.initials: G
authors.lastname: Gu
authors.affiliation: Shanghai Medical Imaging Institute, Shanghai 200032, P.R. China; Department of Sports Medicine and Arthroscopy Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wan
authors.affiliation: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Shanghai Medical Imaging Institute, Shanghai 200032, P.R. China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Cheng
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Haiyin
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Fan
authors.affiliation: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Y I
authors.initials: YI
authors.lastname: Han
authors.affiliation: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Tong
authors.affiliation: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Chenling
authors.initials: C
authors.lastname: Yao
keywords: acute aortic dissection; lumican; multi-slice computed tomography angiography