title: Effect of Lactobacillus Strains on Intestinal Microflora and Mucosa Immunity in Escherichia coli O157:H7-Induced Diarrhea in Mice.
abstract: This study investigated the effects of KLDS 1.8701 and AD1 administrations by gavage on intestinal microflora and mucosal immunity in diarrhea mice infected by Escherichia coli O157:H7 compared to normal mice. The levels of E. coli, Enterobacteria, and Enterococcus decreased significantly (P < 0.05), while viable counts of Lactobacilli and Bifidobacterium increased in diarrhea mice. Moreover, KLDS 1.8701 and AD1 improved secretion of secretory immunoglobulin A and enhanced the levels of interferon-γ and interleukin. Results indicate that KLDS 1.8701 and AD1 could effectively alleviate diarrhea in mice via modulation of intestinal microflora and improve the function of immune system. The study on the effect of KLDS1.8701 and AD1 supplementation in human flora-associated animal models was recommended.
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Bian
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.
authors.forename: Smith Etareri
authors.initials: SE
authors.lastname: Evivie
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Luo
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.
authors.forename: Hong-Zhang
authors.initials: HZ
authors.lastname: Liang
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.
authors.forename: Shang-Fu
authors.initials: SF
authors.lastname: Yu
authors.affiliation: Key Laboratory of Dairy Science, College of Food Sciences, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China. guichenghuo1958@163.com.
authors.forename: Gui-Cheng
authors.initials: GC
authors.lastname: Huo
mesh_terms: D000818:Animals; D003967:Diarrhea / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D019453:Escherichia coli O157 / Q000502:physiology*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D006801:Humans; D007109:Immunity; D007778:Lactobacillus / Q000276:immunology / Q000502:physiology*; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology* / Q000382:microbiology; D019936:Probiotics / Q000008:administration & dosage*