title: Spironolactone, a therapeutic alternative in the treatment of diffuse retinal pigment epitheliopathy.
abstract: METHODS
  Two cases are presented of patients with chronic diffuse epitheliopathy (CDE) that showed a favourable response when treated with spironolactone. The first patient had regions of neurosensory detachment (DNS) and the second, multiple DNS, secondary intra-retinal cysts and retinal pigment epithelium detachment.
  
  
  CONCLUSIONS
  After treatment with spironolactone, both patients showed a visual acuity improvement and structural changes (reduced neurosensory retinal detachment and cystoid degeneration). Aldosterone receptor agonists (ARA) used for persistent forms of chronic central serous chorioretinopathy show encouraging results and could represent a therapeutic alternative for CDE.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna, Tenerife, España. Electronic address: dangelp300@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Ángel-Pereira
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna, Tenerife, España.
authors.forename: P
authors.initials: P
authors.lastname: Rocha-Cabrera
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna, Tenerife, España.
authors.forename: L
authors.initials: L
authors.lastname: Cordovés-Dorta
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna, Tenerife, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Losada Castillo
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna, Tenerife, España.
authors.forename: A
authors.initials: A
authors.lastname: Blasco Alberto
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna, Tenerife, España.
authors.forename: J A
authors.initials: JA
authors.lastname: Abreu Reyes
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use*; D012163:Retinal Detachment / Q000188:drug therapy*; D013148:Spironolactone / Q000627:therapeutic use*
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone
keywords: Aldosterona; Aldosterone; Antagonistas; Antagonists; Chronic; Crónica; Diffuse; Difusa; Epiteliopatía; Epitheliopathy; Espironolactona; Receptor; Receptores; Spironolactone