title: Purinyl N(3)-Directed Palladium-Catalyzed C-H Alkoxylation of N(9)-Arylpurines: A Late-Stage Strategy to Synthesize N(9)-(ortho-Alkoxyl)arylpurines.
abstract: A palladium-catalyzed alkoxylation of N(9)-arylpurines with primary or secondary alcohols has been developed successfully, which is a rare C-H activation reaction of polynitrogenated purines and offers a late-stage strategy to synthesize N(9)-(ortho-alkoxyl)arylpurines. Although there are more than four nitrogen atoms present in the purine moiety, the reaction can be effectively conducted by sterically blocking the N(1) site for catalyst coordination and first employing the purinyl N(3) atom as a directing group.
authors.affiliation: Faculty of Science, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Mingwu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Faculty of Science, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Zhiqian
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Faculty of Science, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Miao
authors.initials: M
authors.lastname: Tian
authors.affiliation: Faculty of Science, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Chenghu
authors.initials: C
authors.lastname: Lu
authors.affiliation: Faculty of Science, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Shunlai
authors.initials: S
authors.lastname: Li
authors.affiliation: Faculty of Science, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Du