title: [Genome-wide association study for adolescent idiopathic scoliosis].
abstract: Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also been performed in the USA and China, which identified one and three susceptibility genes, respectively. Here we review GWASs in Japan and abroad and functional analysis to clarify the pathomechanism of AIS.
authors.affiliation: Department of Orthopaedic Surgery, Keio University, Japan.Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Japan.
authors.forename: Yoji
authors.initials: Y
authors.lastname: Ogura
authors.affiliation: Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Japan.
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Kou
authors.affiliation: Japan Scoliosis Clinical Research Group.
authors.forename: Japan
authors.initials: J
authors.lastname: Scoliosis
authors.affiliation: Department of Orthopaedic Surgery, Keio University, Japan.
authors.forename: Morio
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Department of Orthopaedic Surgery, Keio University, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D000293:Adolescent; D000818:Animals; D002899:Chromosomes, Human, Pair 9; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012600:Scoliosis / Q000453:epidemiology / Q000235:genetics*