title: Impact of Severe Obesity and Weight Loss on Systolic Left Ventricular Function and Morphology: Assessment by 2-Dimensional Speckle-Tracking Echocardiography.
abstract: Obesity is associated with an increased risk of heart failure. Little is known about the impact of dietary changes on the cardiac sequelae in obese patients. Twenty-one obese subjects underwent a 12-week low calorie fasting phase of a formula diet. Transthoracic two-dimensional speckle-tracking echocardiography was performed to obtain systolic left ventricular strain before and after weight loss. Body mass index decreased significantly from 38.6 ± 6.2 to 31.5 ± 5.3 kg/m(2), and the total percentage fat loss was 19%. Weight reduction was associated with a reduction in blood pressure and heart rate. Left ventricular longitudinal global peak systolic strain was in the lower normal range (-18.7 ± 3.2%) before weight loss and was unchanged (-18.8 ± 2.4%) after 12 weeks on diet with substantial weight loss. Also, no significant change in global radial strain after weight loss was noted (41.1 ± 22.0 versus 43.9 ± 23.3, p = 0.09). Left atrial and ventricular dimensions were in normal range before fasting and remained unchanged after weight loss. In our study obesity was associated with normal systolic left ventricular function. A 12-week low calorie diet with successful weight loss can reduce blood pressure and heart rate. Systolic left ventricular function and morphology were not affected by rapid weight reduction.
authors.affiliation: Department of Internal Medicine-Cardiology, Hospital Sachsenhausen, 60594 Frankfurt, Germany.
authors.forename: Sevda
authors.initials: S
authors.lastname: Karimian
authors.affiliation: Department of Internal Medicine-Gastroenterology, Hospital Sachsenhausen, 60594 Frankfurt, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Stein
authors.affiliation: Department of Radiology, Hospital Sachsenhausen, 60594 Frankfurt, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Bauer
authors.affiliation: Department of Internal Medicine-Cardiology, Hospital Sachsenhausen, 60594 Frankfurt, Germany.
authors.forename: Claudius
authors.initials: C
authors.lastname: Teupe
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015897:Comorbidity; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D015203:Reproducibility of Results; D012307:Risk Factors; D013318:Stroke Volume; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000473:pathology / Q000503:physiopathology*; D016277:Ventricular Function, Left; D015431:Weight Loss