title: The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes.
abstract: Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by T cell-mediated destruction of the insulin-producing pancreatic β cells. A combination of genetic and environmental factors eventually leads to the loss of functional β cell mass and hyperglycemia. Both innate and adaptive immunity are involved in the development of T1D. In this review, we have highlighted the most recent findings on the role of innate immunity, especially the pattern recognition receptors (PRRs), in disease development. In murine models and human studies, different PRRs, such as toll-like receptors (TLRs) and nucleotide-binding domain, leucine-rich repeat-containing (or Nod-like) receptors (NLRs), have different roles in the pathogenesis of T1D. These PRRs play a critical role in defending against infection by sensing specific ligands derived from exogenous microorganisms to induce innate immune responses and shape adaptive immunity. Animal studies have shown that TLR7, TLR9, MyD88 and NLPR3 play a disease-predisposing role in T1D, while controversial results have been found with other PRRs, such as TLR2, TLR3, TLR4, TLR5 and others. Human studies also shown that TLR2, TLR3 and TLR4 are expressed in either islet β cells or infiltrated immune cells, indicating the innate immunity plays a role in β cell autoimmunity. Furthermore, some human genetic studies showed a possible association of TLR3, TLR7, TLR8 or NLRP3 genes, at single nucleotide polymorphism (SNP) level, with human T1D. Increasing evidence suggest that the innate immunity modulates β cell autoimmunity. Thus, targeting pathways of innate immunity may provide novel therapeutic strategies to fight this disease.
authors.affiliation: Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, USA.
authors.forename: Ningwen
authors.initials: N
authors.lastname: Tai
authors.affiliation: Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
authors.forename: F Susan
authors.initials: FS
authors.lastname: Wong
authors.affiliation: Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, USA. Electronic address: li.wen@yale.edu.
authors.forename: Li
authors.initials: L
authors.lastname: Wen
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D007113:Immunity, Innate; D050417:Insulin-Secreting Cells / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D016688:Mice, Inbred NOD; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors
keywords: Adaptive immunity; Innate immunity; Pattern recognition receptors; Type 1 diabetes; β cells