title: Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease.
abstract: Cheilitis granulomatosa is characterized by granulomatous lip swelling. We report a case of a 13-year-old girl who presented with orofacial swelling and arthralgia, who eventually was diagnosed with Crohn's disease, which was successfully treated with infliximab and azathioprine combination therapy. Recurrent or persistent orofacial swelling should prompt consideration of cheilitis granulomatosa, and further diagnostic evaluation to exclude the presence of Crohn's disease seems warranted.
authors.affiliation: Department of Pediatric Gastroenterology and Nutrition, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. d.r.hoekman@amc.uva.nl.|Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands. d.r.hoekman@amc.uva.nl.
authors.forename: Daniël R
authors.initials: DR
authors.lastname: Hoekman
authors.affiliation: Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Joris J T H
authors.initials: JJ
authors.lastname: Roelofs
authors.affiliation: Department of Pediatric Radiology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: van Schuppen
authors.affiliation: Department of Pediatric Rheumatology and Immunology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Dieneke
authors.initials: D
authors.lastname: Schonenberg-Meinema
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Geert R
authors.initials: GR
authors.lastname: D'Haens
authors.affiliation: Department of Pediatric Gastroenterology and Nutrition, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Benninga
mesh_terms: D000293:Adolescent; D018771:Arthralgia / Q000209:etiology*; D001379:Azathioprine / Q000627:therapeutic use; D003424:Crohn Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000069285:Infliximab / Q000627:therapeutic use; D008556:Melkersson-Rosenthal Syndrome / Q000209:etiology*
chemical_list: D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents; D000069285:Infliximab; D001379:Azathioprine
keywords: Cheilitis granulomatosa; Crohn’s disease; Inflammatory bowel disease; Lip swelling; Orofacial granulomatosis