title: CoDNaS 2.0: a comprehensive database of protein conformational diversity in the native state.
abstract: CoDNaS (conformational diversity of the native state) is a protein conformational diversity database. Conformational diversity describes structural differences between conformers that define the native state of proteins. It is a key concept to understand protein function and biological processes related to protein functions. CoDNaS offers a well curated database that is experimentally driven, thoroughly linked, and annotated. CoDNaS facilitates the extraction of key information on small structural differences based on protein movements. CoDNaS enables users to easily relate the degree of conformational diversity with physical, chemical and biological properties derived from experiments on protein structure and biological characteristics. The new version of CoDNaS includes ∼70% of all available protein structures, and new tools have been added that run sequence searches, display structural flexibility profiles and allow users to browse the database for different structural classes. These tools facilitate the exploration of protein conformational diversity and its role in protein function. Database URL:http://ufq.unq.edu.ar/codnas.
authors.affiliation: Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Argentina.
authors.forename: Alexander Miguel
authors.initials: AM
authors.lastname: Monzon
authors.affiliation: Instituto de Ecología Genética y Evolución de Buenos Aires (IEGEBA)-Laboratorio de Genómica Médica y Evolución, Universidad Nacional de Buenos Aires, Argentina.
authors.forename: Cristian Oscar
authors.initials: CO
authors.lastname: Rohr
authors.affiliation: Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Argentina.
authors.forename: María Silvina
authors.initials: MS
authors.lastname: Fornasari
authors.affiliation: Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Argentina gusparisi@gmail.com.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Parisi
mesh_terms: D030562:Databases, Protein; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D057386:Search Engine
chemical_list: D011506:Proteins