title: Studies on the in vitro and in vivo degradation behavior of amino acid derivative-based organogels.
abstract: The in vitro degradation behavior of organogel with different gelators based on amino acid was investigated in detail. Two methods were applied in this research: weighting method and high-performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD) method, which was established for the first time. Their degradation behaviors in vivo were investigated by varying the kind and concentration of gelators via subcutaneous implantation. The results showed that the stronger the gelation ability or the higher the gelator concentration, the slower the degradation rate of organogel. Moreover, the organogel prepared by oils with longer alkyl length degraded slower than that of the shorter ones, which also decreased in thermal stability and mechanical strength. The investigation on degradation process showed that the degradation rate was mainly controlled by the collapse of network structure formed by gelators. In conclusion, organogel had a tunable degradation rate through altering the gelator type, oil type and the gelator concentration. It remains a promising candidate for subcutaneous in-situ implant as drug delivery vehicle.
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Jinxu
authors.initials: J
authors.lastname: Cao
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Hu
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Heran
authors.initials: H
authors.lastname: Li
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Hongzhuo
authors.initials: H
authors.lastname: Liu
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Zhenyun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Tong
authors.affiliation: a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , PR China.
authors.forename: Sanming
authors.initials: S
authors.lastname: Li
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D005782:Gels
keywords: Degradation process; HPLC-ELSD; in vitro degradation; in vivo degradation; organogel