title: [Managment of subretinal heamorrhages within the macular area using intravitreal injections of recombined tissue plasminogen activator, sulphur hexafluoride and ranihizumab--preliminary report].
abstract: Submacular hemorrhages cause serious vision impairment. Patient observation, waiting for the spontaneous blood reabsorption and resolution of the haemorrhage leads to the severe damage to retinal tissue as a result of scar formation. The paper presents 7 cases of patients with submacular haemorrhages treated with intravitreal injections of recombined tissue plasminogen activator (rtPA) and sulphur hexafluoride (SFG). In 4 cases, the haemorrhage was secondary to AMD, in two cases to trauma, and it was idiopathic in one case. All patients were treated with intravitreal injections of rtPA and SF6 for thrombolysis and pneumatic displacement of haemorrhage outside macular structures. Ranibizumab was additionally administered to patients with age-related macular degeneration. Such treatment improved visual acuity in all patients, reducing the central retinal thickness as shown in follow-up optical coherence tomography. The presented treatment of submacular hemorrhages with intravitreal injections of rtPA and SF6 provided good results, but in order to develop a standard management algorithm for this disease, the analysis of larger patient sample is required.
authors.forename: Joanna
authors.initials: J
authors.lastname: Miniewicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kubicka-Trząska
authors.forename: Izabella
authors.initials: I
authors.lastname: Karska-Basta
authors.forename: Boźena
authors.initials: B
authors.lastname: Romanowska-Dixon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004359:Drug Therapy, Combination; D006801:Humans; D058449:Intravitreal Injections; D008266:Macula Lutea / Q000187:drug effects*; D008268:Macular Degeneration / Q000188:drug therapy; D008875:Middle Aged; D000069579:Ranibizumab / Q000008:administration & dosage*; D012166:Retinal Hemorrhage / Q000188:drug therapy*; D013459:Sulfur Hexafluoride / Q000008:administration & dosage*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
chemical_list: D010959:Tissue Plasminogen Activator; D013459:Sulfur Hexafluoride; D000069579:Ranibizumab