title: [Circuit resistance training improved endothelial dysfunction in obese aged women].
abstract: BACKGROUND
  It is widely accepted that obesity is associated with endothelial dysfunction. In a recent paper, we have also found circuit resistance training may reduce visceral fat in obese aged women. Accordingly, the current study was conducted to ascertain the effects of circuit resistance training on markers of endothelial dysfunction in this population group.
  
  
  METHODS
  In the present interventional study, a total of 48 obese aged women were recruited from the community. Twenty-four of them were randomly assigned to perform a 12-week resistance circuit training programme, 3-days per week. This training was circularly performed in 6 stations: arm curl, leg extension, seated row, leg curl, triceps extension and leg press. The Jamar handgrip electronic dynamometer was used to assess maximal handgrip strength of the dominant hand. Lastly, serum samples were analysed using an immunoassay (ELISA) for endothelin-1, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).
  
  
  RESULTS
  When compared to baseline, resistance training significantly reduced serum levels of endothelin-1 (2.28 ± 0.7 vs. 1.98 ± 1.1 pg/ml; p = 0.019; d = 0.67) and ICAM-1 (290 ± 69 vs. 255 ± 76 ng/ml; p = 0.004; d = 0.92) in the experimental group. No significant changes in any of the tested outcomes were found in the control group.
  
  
  CONCLUSIONS
  A short-term circuit resistance program improved endothelial dysfunction in aged obese women. Further studies on this topic are still required to consolidate this approach in clinical application.
authors.affiliation: . nutricion@grupoaran.com.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rosety
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Pery
authors.forename: Jesús
authors.initials: J
authors.lastname: Rosety
authors.forename: Natalia
authors.initials: N
authors.lastname: García
authors.forename: María Antonia
authors.initials: MA
authors.lastname: Rodríguez-Pareja
authors.forename: Francisco
authors.initials: F
authors.lastname: Brenes-Martín
authors.forename: Antonio
authors.initials: A
authors.lastname: Díaz
authors.forename: Manuel
authors.initials: M
authors.lastname: Rosety-Rodríguez
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Ordoñez
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Rosety
mesh_terms: D000368:Aged; D004730:Endothelium, Vascular; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008875:Middle Aged; D053581:Muscle Strength Dynamometer; D009765:Obesity / Q000628:therapy*; D055070:Resistance Training / Q000379:methods*; D016896:Treatment Outcome; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism; D014652:Vascular Diseases / Q000628:therapy
chemical_list: D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
keywords: Aged; Endothelin-1; Endothelium disorder; Intercellular adhesion molecule-1; Resistance training; Vascular cell adhesion molecule-1