title: Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells.
abstract: This study aimed to determine the effect of multidrug and toxin extrusion protein 1 (MATE1) genetic variants on its transcript expression in peripheral blood cells. Consistent with previous in vitro findings, MATE1 mRNA levels were significantly higher in subjects carrying rs2453579, but not rs2252281, compared to those without either of these promoter variants. In addition, the mRNA levels did not differ between subjects with both variants and those with neither allele. Thus, this study reveals that the influence of MATE1 genetic variants on its mRNA expression can be detected in vivo using peripheral blood.
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ando
authors.affiliation: Department of Urology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakano
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ushijima
authors.affiliation: Department of Urology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kurokawa
authors.affiliation: Department of Urology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Washino
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Hosohata
authors.affiliation: Department of Urology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Morita
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. Electronic address: akiofuji@jichi.ac.jp.
authors.forename: Akio
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001773:Blood Cells / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D008297:Male; D027701:Organic Cation Transport Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D027701:Organic Cation Transport Proteins; D012333:RNA, Messenger; C521869:SLC47A1 protein, human
keywords: Multidrug and toxin extrusion protein 1 (MATE1); Peripheral blood cell; Polymorphism