title: The role of surface modification for TiO2 nanoparticles in cancer cells.
abstract: Titanium dioxide nanoparticles (TiO2 NPs) have a potential in the field of biological application. However, its poor dispersibility in water hampered its applications. In this study, 3-phosphonopropionic acid and 3-aminopropyl-triethoxysilane were respectively used for surface modification on TiO2 NPs with negative and positive surface charges (denoted as TiO2-COOH and TiO2-NH2). Zeta potentials of the prepared samples with high absolute value demonstrate the great improvement in their dispersibility. In terms of viability experiment, both TiO2-COOH and TiO2-NH2 showed low cytotoxicity. The cellular uptake efficiency and the uptake pathways of TiO2-COOH and TiO2-NH2 for cancer cells were studied. The exocytosis of TiO2-NH2 was also observed in the experiment.
authors.affiliation: Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Mengyan
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Yiyan
authors.initials: Y
authors.lastname: Fei
authors.affiliation: Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Pei-Nan
authors.initials: PN
authors.lastname: Wang
authors.affiliation: Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, PR China. Electronic address: lanmi@fudan.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Mi
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004705:Endocytosis; D005089:Exocytosis; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011437:Propylamines / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D055672:Static Electricity; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D009943:Organophosphorus Compounds; D011437:Propylamines; D012821:Silanes; C009495:titanium dioxide; C003128:beta-phosphonopropionic acid; D014025:Titanium; C477625:amino-propyl-triethoxysilane
keywords: Endocytosis; Surface modification; Titanium dioxide