title: Polymeric Micelles with Uniform Surface Properties and Tunable Size and Charge: Positive Charges Improve Tumor Accumulation.
abstract: The influence of surface charge on biodistribution and tumor accumulation remains debatable because most research has been carried out by changing the surface functional groups of nanocarriers. In this work, to avoid the interference of different surface properties such as chemical composition and hydrophilicity, polymeric micelles with uniform PEG coatings and continuously tunable sizes or zeta potentials were developed via a facile route. Therefore, the influence of surface charge on the biological functions of micelles with the same size and surface properties could be well-explored. In this case, positive charge was found to enhance both tumor cellular uptake and tumor accumulation. Immunofluorescence staining indicated that the improved tumor accumulation was mainly due to the tumor vasculature targeting of positively charged micelles. It is predicted that efficient drug delivery systems for both tumor vasculature and cancer cell targeting can be realized based on positively charged micelles.
authors.affiliation: The State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology , Beijing 100029, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Shen
authors.affiliation: The State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology , Beijing 100029, China.
authors.forename: Shuli
authors.initials: S
authors.lastname: Guan
authors.affiliation: The State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology , Beijing 100029, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Gan
authors.affiliation: Department of Urology, China-Japan Friendship Hospital , Beijing 100029, China.
authors.forename: Guan
authors.initials: G
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology , Beijing 100029, China.
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008807:Mice, Inbred BALB C; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D011092:Polyethylene Glycols; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D014018:Tissue Distribution
chemical_list: D000903:Antibiotics, Antineoplastic; D008823:Micelles; D011108:Polymers; D011092:Polyethylene Glycols; D004317:Doxorubicin