title: [Relapse of acute promyelocytic leukemia in the central nervous system revealed by isolated dementia].
abstract: BACKGROUND
  Approximately 1.5% of dementia is due to curable aetiology. We report an isolated dementia syndrome due to a meningeal relapse of acute promyelocytic leukaemia with favourable outcome after appropriate treatment.
  
  
  METHODS
  A 72-year-old woman, in remission of an acute promyelocytic leukaemia, presented a loss of autonomy for several months due to corticosubcortical dementia. Lumbar puncture showed blast cells indicating meningeal relapse of leukaemia. Intrathecal chemotherapy and arsenic trioxide obtained biological and molecular remission as well as restoration of normal cognitive functions.
  
  
  CONCLUSIONS
  In patients with hematologic past history such as acute promyelocytic leukaemia, an isolated cognitive impairment should alert physicians to search for an isolated neuromeningeal relapse.
authors.affiliation: Service de neurologie et neuropsychologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France. Electronic address: olivier.colin@chu-poitiers.fr.
authors.forename: O
authors.initials: O
authors.lastname: Colin
authors.affiliation: Service de neurologie et neuropsychologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France; Centre mémoire de ressources et de recherche Poitou-Charentes, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: A
authors.initials: A
authors.lastname: Julian
authors.affiliation: Service d'onco-hématologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: M
authors.initials: M
authors.lastname: Puyade
authors.affiliation: Laboratoire d'hématologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: S
authors.initials: S
authors.lastname: Bouyer
authors.affiliation: Centre mémoire de ressources et de recherche Poitou-Charentes, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: E
authors.initials: E
authors.lastname: Meurin
authors.affiliation: Centre mémoire de ressources et de recherche Poitou-Charentes, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: S
authors.initials: S
authors.lastname: Blondeau
authors.affiliation: Service de neurologie et neuropsychologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France; Centre mémoire de ressources et de recherche Poitou-Charentes, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Houeto
authors.affiliation: Service de neurologie et neuropsychologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France; Centre mémoire de ressources et de recherche Poitou-Charentes, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Neau
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use*; D003704:Dementia / Q000175:diagnosis*; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010087:Oxides / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction
chemical_list: D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide
keywords: Acute promyelocytic leukaemia; Central nervous system; Dementia; Démence; Leucémie aiguë promyélocytaire; Rechute; Relapse; Système nerveux central