title: MicroRNA-497 suppresses osteosarcoma tumor growthin vitroandin vivo.
abstract: It has been demonstrated that microRNA-497 (miR-497) acts as a tumor suppressor and is involved in tumor progression, development and metastasis in several types of cancer. However, little is known about the exact role of miR-497 in osteosarcoma (OS). The aim of the current study was to investigate the potential role of miR-497 in human OS. The role of miR-497 in the growth and survival of OS cells was determined using severalin vitroapproaches and a nude mouse model. The results demonstrated that exogenous expression of miR-497 in human OS MG63 cells suppressed cell proliferation, colony formation, migration and invasion, and induced cell apoptosis and cell arrest at the G0/G1 phase of the cell cycle. In addition, the results of thein vivostudy indicated that restoration of miR-497 inhibited OS tumor growth in a nude mouse model. Overall, the results of the present study identified a crucial tumor suppressive role of miR-497 in the progression of OS, and suggested that miR-497 may be a potential therapeutic agent for the treatment of OS.
authors.affiliation: Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ge
authors.affiliation: Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Baisong
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.
authors.forename: Minghe
authors.initials: M
authors.lastname: Li
authors.affiliation: Operating Room, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Niu
authors.affiliation: Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Li
keywords: miR-497; microRNAs; osteosarcoma; tumor growth