title: The clinical and biochemical characteristics associated with insulin resistance in non-obese young women.
abstract: OBJECTIVE
  The aim of this study was to investigate the biomarkers of insulin resistance in non-obese women.
  
  
  METHODS
  This was a retrospective study.
  
  
  METHODS
  A total 229 non-obese women (Body mass index: BMI < 25) were evaluated.
  
  
  METHODS
  Serum levels of various androgens, cardiovascular risk and metabolic components.
  
  
  RESULTS
  There were no significant differences in the prevalence of polycystic ovary syndrome (PCOS), hyperprolactinemia, or premature ovarian failure (POF) between the non-obese women with and without insulin resistance. Non-obese women with insulin had significantly higher serum thyroid stimulation hormone (TSH) levels and resistin and lower serum adiponectin levels than non-obese women without insulin resistance; however, the inflammatory biomarkers and serum androgen levels did not differ between the two groups. Furthermore, using step-wise multivariate regression analysis applied by the risk factors listed above, TSH was the only predictive factor for insulin resistance in non-obese reproductive-aged women.
  
  
  CONCLUSIONS
  Thyroid function should play an important role in developing insulin resistance for non-obese women. Serum androgens and inflammation might not contribute to insulin resistance in these women.
authors.affiliation: a School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei , Taiwan.
authors.forename: Ching-Chiung
authors.initials: CC
authors.lastname: Wang
authors.affiliation: b Department of Internal Medicine , Section of Endocrinology and Metabolism, Taipei Medical University, Wan Fang Hospital , Taipei , Taiwan.
authors.forename: Chun-Jen
authors.initials: CJ
authors.lastname: Chang
authors.affiliation: c Department of Obstetrics and Gynecology , School of Medicine, College of Medicine, Taipei Medical University , Taipei , Taiwan , and.|d Department of Obstetrics and Gynecology , Wan Fang Hospital, Taipei Medical University , Taipei , Taiwan.
authors.forename: Ming-I
authors.initials: MI
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000453:epidemiology; D007333:Insulin Resistance / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000453:epidemiology; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology; D013972:Thyrotropin / Q000097:blood*; D055815:Young Adult
chemical_list: D000728:Androgens; D013972:Thyrotropin
keywords: Androgens; PCOS; TSH; insulin resistance; non-obesity