title: Synergistic eradication of antibiotic-resistant bacteria based biofilms in vivo using a NIR-sensitive nanoplatform.
abstract: In this work, a novel multifunctional NIR-sensitive nanoplatform has been developed for synergistic eradication of antibiotic-resistant bacteria based biofilms in vitro and in vivo. With high biocompatibility and an outstanding synergistic effect, our system provides a promising avenue to preventing and combating biofilm-associated infections.
authors.affiliation: State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.forename: Nan
authors.initials: N
authors.lastname: Gao
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000528:radiation effects; D018407:Bacterial Physiological Phenomena / Q000187:drug effects / Q000528:radiation effects; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004352:Drug Resistance, Microbial; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D009569:Nitric Oxide