title: Polymorphisms in VEGF-A are associated with COPD risk in the Chinese population from Hainan province.
abstract: In this study, we examined and validated how common variants contribute to susceptibility to chronic obstructive pulmonary disease (COPD) in the Han Chinese population. Here, we genotyped 18 nucleotide polymorphisms and evaluated their association with COPD using chi-square test and genetic model analysis (246 COPD patients and 350 controls), and found three SNPs that might cause a predisposition to COPD. Both rs3025030 and rs3025033 are located on chromosome 6 in VEGF-A. We found one risk allele 'C' from rs3025030 and another 'G' from rs3025033 using the log-additive model (OR 1.40; 95% CI 1.05-5.96; P = 0.022), (OR 1.38; 95% CI 1.03-1.84; P = 0.03). We also found another risk allele 'A' of rs9296092 in gene region ZBTB9-BAK1 by the allele model (OR 2.63; 95% CI 1.27-5.45; P = 0.0078), (adjusted OR 3.53; 95% CI 1.12-11.11; P = 0.031).We found a risk haplotype 'CG' associated with the risk of COPD (OR 1.39; 95% CI 1.04-1.86; P = 0.028). Our results when compared with previous studies showed significant association between VEGF-A polymorphism and COPD. We also identified rs9296092 as a risk factor for COPD.
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan 570311,People's Republic of China;ypding@263.net.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Ding
authors.forename: Huan
authors.initials: H
authors.lastname: Niu
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.forename: Quanni
authors.initials: Q
authors.lastname: Li
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Hu
authors.forename: Youqing
authors.initials: Y
authors.lastname: Zhong
authors.forename: Pei
authors.initials: P
authors.lastname: Sun
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
mesh_terms: D000368:Aged; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A