title: Periplaneta americana extract used in patients with systemic inflammatory response syndrome.
abstract: BACKGROUND
  Periplaneta americana extract is recognized to have a positive effect on gastrointestinal mucosa. This study aimed to investigate the effects of periplaneta americana extract on immune function, nutrition status and gastrointestinal complications of early enteral nutrition patients with systemic inflammatory response syndrome (SIRS).
  
  
  METHODS
  Patients with SIRS were randomly divided into two groups: treatment and control groups. All patients in the two groups received conventional therapy including enteral nutrition, but periplaneta americana extract, an additional Chinese medicine, was given to the patients in the treatment group. At the beginning of treatment (0 day) and 1, 3, and 7 days after treatment, the levels of immunoglobulin (IgA), total lymphocyte count (TLC), total protein (TP) and prealbumin (PA) were respectively tested in patients' venous blood. The incidences of bloating, diarrhea, aspiration pneumonia and high blood sugar at 7 days after treatment were recorded. The mortality of the patients in 28 days was recorded.
  
  
  RESULTS
  At 3 and 7 days after treatment, the levels of IgA and TLC in the treatment group were higher than those in the control group (P<0.05). At 7 days after treatment, the levels of TP and PA in the treatment group were higher than those in the control group (P<0.05). The incidences of bloating and diarrhea in the treatment group were lower than those in the control group, the differences were significant (P<0.05). The mortality of treatment group was lower than that of the control group (P>0.05).
  
  
  CONCLUSIONS
  Periplaneta americana extract could reduce gastrointestinal complications and improve immune function and nutritional status in patients with systemic inflammatory response syndrome.
authors.affiliation: Department of Intensive Care Unit, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China.
authors.forename: Li-You
authors.initials: LY
authors.lastname: Wei
authors.affiliation: Department of Intensive Care Unit, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Clinical Laboratory, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China.
authors.forename: Ya-Jing
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Department of Intensive Care Unit, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China.
authors.forename: Shu-Zheng
authors.initials: SZ
authors.lastname: Liu
authors.affiliation: Department of Intensive Care Unit, People's Hospital of Tangshan, Tangshan 063001, China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Department of Intensive Care Unit, People's Hospital of Tangshan, Tangshan 063001, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Department of Intensive Care Unit, People's Hospital of Tangshan, Tangshan 063001, China.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Hu
keywords: Enteral nutrition; Gastrointestinal function; Nutritional status; Periplaneta americana extract; Systemic inflammatory response syndrome; immune function