title: Lewis Acid Catalyzed Friedel-Crafts Alkylation of Alkenes with Trifluoropyruvates.
abstract: A Friedel-Crafts alkylation reaction of styrenes with trifluoropyruvates has been developed, which delivered allylic alcohols in excellent yields (up to 98%) using the Ni(ClO4)2·6H2O/bipyridine complex as a catalyst. The asymmetric reaction was catalyzed by the chiral Cu(OTf)2/bisoxazoline complex to afford the corresponding chiral allylic alcohols bearing trifluoromethylated quaternary stereogenic centers in moderate enantioselectivities (up to 75% ee).
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xiang
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Xu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Gao
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Yi-Xia
authors.initials: YX
authors.lastname: Jia