title: THE EFFECT OF THE ALUMINUM CHLORIDE--QUERCETIN COMPLEX ON Ca2+, Mg(2+)-ATPase ACTIVITY AND CONTRACTION DYNAMIC PROPERTIES OF MUSCLE TIBIALIS ANTERIOR FROM RANA TEMPORARIA.
abstract: Combined effect of aluminum chloride and quercetin solutions on the enzymatic activity and contraction dynamics of muscle fiber bundles of the Rana temporaria m. tibialis anterior was investigated. It was shown that these complexes inhibit muscle contraction. Linear reduction of Ca2+, Mg(2+)-ATPase activity induced by all of the used concentrations of AlCl3 - quercetin was demonstrated. It was found that complex of quercetin with AlCl3 has a greater inhibitory effect on muscle contraction dynamic and causes greater reduction during all periods of stimulation in comparison to the separate effect of the investigated compounds. All the studied concentrations of AlCl3 and quercetin solutions (AlCl3: 10(-4)-10(-2) M; quercetin: 10(-6)-10(-5) M) caused concentration depended contraction strengths and lengths reduction. The decrease in strength and length of muscle contractions was of constant and mostly linear nature within observed timeframe as well as within each periods of contraction. The changes were least pronounced within pretetanic period, but were profound within terminal period of muscle activity. The changes in dynamic contraction properties and Ca2+, Mg(2+)-ATPase activity of sarcoplasmic reticulum under effect of the investigated compounds was minimal in the beginning of the muscle's response to stimulus, prior to muscle strength reaching stable contraction level.
authors.forename: D M
authors.initials: DM
authors.lastname: Nozdrenko
authors.forename: O M
authors.initials: OM
authors.lastname: Abramchuk
authors.forename: V M
authors.initials: VM
authors.lastname: Soroca
authors.forename: N S
authors.initials: NS
authors.lastname: Miroshnichenko
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D011794:Quercetin / Q000494:pharmacology*; D011896:Rana temporaria; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D046509:Tissue Culture Techniques
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D011794:Quercetin; D017301:Ca(2+) Mg(2+)-ATPase