title: Effects of Renal Denervation on Renal Artery Function in Humans: Preliminary Study.
abstract: OBJECTIVE
  To study the effects of RD on renal artery wall function non-invasively using magnetic resonance.
  
  
  RESULTS
  32 patients undergoing RD were included. A 3.0 Tesla magnetic resonance of the renal arteries was performed before RD and after 6-month. We quantified the vessel sharpness of both renal arteries using a quantitative analysis tool (Soap-Bubble®). In 17 patients we assessed the maximal and minimal cross-sectional area of both arteries, peak velocity, mean flow, and renal artery distensibility. In a subset of patients wall shear stress was assessed with computational flow dynamics. Neither renal artery sharpness nor renal artery distensibility differed significantly. A significant increase in minimal and maximal areas (by 25.3%, p = 0.008, and 24.6%, p = 0.007, respectively), peak velocity (by 16.9%, p = 0.021), and mean flow (by 22.4%, p = 0.007) was observed after RD. Wall shear stress significantly decreased (by 25%, p = 0.029). These effects were observed in blood pressure responders and non-responders.
  
  
  CONCLUSIONS
  RD is not associated with adverse effects at renal artery level, and leads to an increase in cross-sectional areas, velocity and flow and a decrease in wall shear stress.
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.
authors.forename: Adelina
authors.initials: A
authors.lastname: Doltra
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.
authors.forename: Arthur
authors.initials: A
authors.lastname: Hartmann
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Stawowy
authors.affiliation: Biofluid Mechanics Laboratory, Charité - Universitätsmedizin Berlin, Berlin, Germany.|Deutsches Herzzentrum Berlin, Department of Congenital Heart Disease and Paediatric Cardiology, Berlin, Germany.
authors.forename: Leonid
authors.initials: L
authors.lastname: Goubergrits
authors.affiliation: Biofluid Mechanics Laboratory, Charité - Universitätsmedizin Berlin, Berlin, Germany.|Deutsches Herzzentrum Berlin, Department of Congenital Heart Disease and Paediatric Cardiology, Berlin, Germany.|DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.
authors.forename: Titus
authors.initials: T
authors.lastname: Kuehne
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.
authors.forename: Ernst
authors.initials: E
authors.lastname: Wellnhofer
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.|DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Gebker
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Schneeweis
authors.affiliation: Philips Healthcare, Clinical Science, Hamburg, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schnackenburg
authors.affiliation: Baker IDI Heart & Diabetes Institute, Melbourne, Australia.
authors.forename: Murray
authors.initials: M
authors.lastname: Esler
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.
authors.forename: Eckart
authors.initials: E
authors.lastname: Fleck
authors.affiliation: Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology, Berlin, Germany.|DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kelle
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D003714:Denervation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007668:Kidney / Q000294:innervation / Q000601:surgery; D008297:Male; D012077:Renal Artery / Q000502:physiology*; D013314:Stress, Mechanical