title: Copper-catalyzed regio- and enantioselective aminoboration of alkylidenecyclopropanes: the synthesis of cyclopropane-containing β-aminoalkylboranes.
abstract: A Cu-catalyzed regio- and enantioselective aminoboration of alkylidenecyclopropanes (ACPs) with bis(pinacolato)-diboron (B2pin2) and hydroxylamines has been described in this paper, affording the corresponding cyclopropane-containing β-aminoalkylboranes in good yields under mild conditions. Moreover, a catalytic asymmetric variant of this transformation has also been realized by using a copper complex with a (S)-BINAP ligand along with further transformation of the product to give cyclopropane-containing 1,2-aminoalcohols.
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road No. 130, Shanghai, 200237, China.
authors.forename: Han-Chun
authors.initials: HC
authors.lastname: Jiang
authors.forename: Xiang-Ying
authors.initials: XY
authors.lastname: Tang
authors.forename: Min
authors.initials: M
authors.lastname: Shi
mesh_terms: D000586:Amination; D001880:Boranes / Q000138:chemical synthesis* / Q000737:chemistry; D001895:Boron / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D006898:Hydroxylamines / Q000737:chemistry*; D009281:Naphthalenes / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C406943:BINAP, 2-naphthol; D001880:Boranes; D003521:Cyclopropanes; D006898:Hydroxylamines; D009281:Naphthalenes; D003300:Copper; D001895:Boron