title: Renal acoustic radiation force impulse elastography in the evaluation of coronary artery disease.
abstract: Background Renal insufficiency may occur in patients with coronary artery disease (CAD). Acoustic radiation force impulse (ARFI) is a method for quantifying tissue elasticity, which could be used as an additional diagnostic test for renal insufficiency and provide an additional contribution to the determination of CAD. Purpose To evaluate ARFI elastography with shear wave velocity (SWV) measurements in the diagnosis of mild-to-moderate chronic kidney disease (CKD) in CAD patients, and to analyze the relationship between the severity of CAD assessed by the Gensini scoring system and kidney stiffness. Material and Methods The study included 76 CAD patients and 79 healthy volunteers. SWV was measured for each kidney in the both groups. The CAD group was divided into two subgroups based on Gensini score: mild CAD and severe CAD. SWV values of the CAD patients were compared to those of the healthy volunteers; values of subgroups were also compared with each other. Results The patient group had significantly lower renal mean SWV values than those of the healthy group (1.87 ± 0.58 vs. 2.34 ± 0.38, P < 0.01). The SWV value decreased as the eGFR level decreased. Mean SWV values for kidneys of the patients with severe CAD were lower than those of the mild CAD patients (1.64 ± 0.39 vs. 2.42 ± 0.60, P < 0.01). Conclusion renal mean SWV values of CAD patients decreased in proportion to the reduction in eGFR, and the SWV values decreased as the severity of CAD increased. ARFI elastography is a novel technique for diagnosing CKD and defining illness severity in CAD patients.
authors.affiliation: 1 Department of Radiology, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Bircan
authors.initials: B
authors.lastname: Alan
authors.affiliation: 1 Department of Radiology, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Cemil
authors.initials: C
authors.lastname: Göya
authors.affiliation: 2 Department of Cardiology, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Aktan
authors.affiliation: 2 Department of Cardiology, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Alan
mesh_terms: D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007668:Kidney / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D051437:Renal Insufficiency / Q000150:complications* / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
keywords: Acoustic radiation force impulse elastography; Gensini score; chronic renal failure; coronary artery disease