title: [Genome-wide association study for rheumatoid arthritis].
abstract: Rheumatoid arthritis(RA)is a multifactorial disease, where both genetic and environmental factors are involved. Genome-wide association studies have been identified more than 100 loci associated with RA. Majority of these loci are expression quantitative trait loci(eQTLs), in which genetic variants regulate the level of transcription. Here, I review the genetic background of RA, by describing the RA-associated genes such as HLA-DRB1, PADI4, and CCR6.
authors.affiliation: Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kochi
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans