title: Mixed adenoneuroendocrine carcinoma (MANEC) of the gastroesophageal junction: a case report and review of the literature.
abstract: Esophageal cancer is the fourth most common neoplasm of the gastrointestinal tract. It is responsible for 1.7% of all deaths related with cancer. The two main types of esophageal cancer are squamous cell carcinoma and adenocarcinoma. Other types of esophageal cancer are uncommon. We present a 57-year-old man admitted to the hospital with nausea and vomiting due to a high-grade malignant mixed adenoneuroendocrine carcinoma of the gastroesophageal junction. The patient underwent Ivor-Lewis esophagectomy and adyuvant chemoradiotherapy. At 8-month follow-up he was alive without evidence of recurrence.
authors.affiliation: Unidad de Endoscopia. Aparato Digestivo, Complejo Hospitalario de Navarra, españa.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Juanmartiñena
authors.affiliation: Digestivo, Complejo Hospitalario de Navarra, España.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Fernández-Urién
authors.affiliation: Departamento de Anatomía Patológica, Complejo Hospitalario de Navarra.
authors.forename: Alicia
authors.initials: A
authors.lastname: Córdoba
authors.affiliation: Departamento de Cirugía Esófago-Gástrica, Complejo Hospitalario de Navarra.
authors.forename: Coro
authors.initials: C
authors.lastname: Miranda
authors.affiliation: Sº de Digestivo. A., Complejo Hospitalario de Navarra, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Borda
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy; D016629:Esophagectomy; D004943:Esophagogastric Junction / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy