title: Germinated Waxy Black Rice Suppresses Weight Gain in High-Fat Diet-Induced Obese Mice.
abstract: This study was performed to investigate the antiobesity effect of germinated waxy black rice (GWBR) in high-fat diet (HFD)-induced obese mice. The mice were divided into a normal diet (ND) group, HFD group, and 2 test groups for 8 weeks: 2.5% GWBR-supplemented (GWBR-2.5) group and 5% GWBR-supplemented (GWBR-5) group. Supplementing with GWBR significantly reduced body weight gain and lipid accumulation in the liver and adipose tissue compared to the HFD control group. Triglyceride (TG), total cholesterol, and low-density lipoprotein-cholesterol levels in serum were decreased by GWBR supplementation, whereas high-density lipoprotein-cholesterol level significantly increased. In addition, mRNA levels of transcriptional factors, such as peroxisome proliferator-activated receptor-γ, CCAAT enhancer-binding protein (C/EBP)-α, C/EBP-β, sterol regulatory element-binding protein-1c, and related genes, including adipocyte fatty acid-binding protein, fatty acid synthase, and lipoprotein lipase, were significantly lower in the GWBR groups. However, lipolytic enzymes, such as hormone-sensitive lipase, adipose TG lipase, and carnitine palmitoyltransferase-1, and uncoupling protein 2 mRNA levels were significantly higher in GWBR-supplemented mice. These results suggest that GWBR exerts antiobesity effects by decreasing lipid accumulation and promoting lipolysis in HFD-induced obese mice.
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Sejong, Korea.
authors.forename: Won-Chul
authors.initials: WC
authors.lastname: Lim
authors.affiliation: 2 Biomedical Research Institute, Seoul National University Bundang Hospital , Seongnam, Korea.
authors.forename: Jin-Nyoung
authors.initials: JN
authors.lastname: Ho
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Sejong, Korea.
authors.forename: Hee-Seop
authors.initials: HS
authors.lastname: Lee
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Sejong, Korea.
authors.forename: Hong-Yon
authors.initials: HY
authors.lastname: Cho
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000235:genetics / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D018525:Germination; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D012275:Oryza / Q000254:growth & development / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000378:metabolism*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D015430:Weight Gain
chemical_list: D022763:CCAAT-Enhancer-Binding Protein-alpha; D047492:Peroxisome Proliferator-Activated Receptors; D010936:Plant Extracts; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D002784:Cholesterol
keywords: antiobesity; germinated waxy black rice; high-fat diet-induced obese mice