title: Troponin T in Patients with Traumatic Chest Injuries with and without Cardiac Involvement: Insights from an Observational Study.
abstract: BACKGROUND
  Serum troponin T (TnT) is a common marker of myocardial injury. However, its implication in the absence of clinical evidence of cardiac reason is not well established.
  
  
  OBJECTIVE
  The aim of this study was to identify the implications of positive TnT in traumatic chest injury (TCI) patients regardless of the cardiac involvement.
  
  
  METHODS
  We conducted a retrospective analysis of all TCI patients admitted to level 1 trauma center between 2008 and 2011. Patients who underwent TnT testing were divided into two groups: Group 1 (positive TnT) and Group 2 (negative TnT). The two groups were analyzed and compared, and multivariate regression analyses were performed to identify predictors of TnT positivity and mortality.
  
  
  RESULTS
  Out of 993 blunt TCI patients, 19.3% had positive TnT (Group 1). On comparison to Group 2, patients in Group 1 were 5 years younger and more likely to have head, cardiac, hepatic, splenic, and pelvic injuries, in addition to lung contusion. Positive TnT was associated with higher Injury Severity Score (ISS) (P = 0.001), higher chest Abbreviated Injury Score (AIS) (P = 0.001), and longer hospital stay (P = 0.03). In addition, Group 1 patients were more likely to undergo chest tube insertion, exploratory laparotomy, mechanical ventilation, and tracheostomy. Twenty patients had cardiac involvement, and of them 14 had positive TnT. Among 973 patients who showed no evidence of cardiac involvement, 178 had positive TnT (18.3%). There were 104 deaths (60% in Group 1). On multivariate regression analysis, the predictors of hospital mortality were positive TnT, head injury, and high ISS, whereas, the predictors of TnT positivity were cardiac, hepatic, and pelvic injuries; higher ISS; and age.
  
  
  CONCLUSIONS
  Positive TnT in blunt TCI patients is a common challenge, particularly in polytrauma cases. Patients with positive TnT tend to have the worst outcome even in the absence of clinical evidence of acute cardiac involvement. Positive TnT is also a reflection of the severity of chest or extrathoracic injuries; however, further prospective studies are warranted.
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Ismail
authors.initials: I
authors.lastname: Mahmood
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar; Department of Clinical Medicine, Weill Cornell Medical College, Doha, Qatar; Department of Internal Medicine, Cardiology Unit, Ahmed Maher Teaching Hospital, Cairo, Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Menyar
authors.affiliation: Department of Clinical Medicine, Weill Cornell Medical College, Doha, Qatar; Department of Cardiology, Hamad General Hospital, Doha, Qatar.
authors.forename: Wafer
authors.initials: W
authors.lastname: Dabdoob
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Yassir
authors.initials: Y
authors.lastname: Abdulrahman
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Tarriq
authors.initials: T
authors.lastname: Siddiqui
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Sajid
authors.initials: S
authors.lastname: Atique
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Arumugam
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar; Department of Surgery, University of Arizona, Tucson, Arizona, USA.
authors.forename: Rifat
authors.initials: R
authors.lastname: Latifi
authors.affiliation: Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Hassan
authors.initials: H
authors.lastname: Al-Thani
keywords: Blunt trauma; cardiac; chest injury; mortality; troponin