title: Combination chemotherapy of solid tumors: an American-Italian collaboration: a celebration of the work of Gianni Bonadonna.
abstract: This article highlights the important collaboration between the U.S. NCI in Bethesda, Maryland and the Istituto Tumori in Milan, Italy that had a major impact on the development of curative regimens for breast cancer, Hodgkin's disease and diffuse large B cell lymphoma.In addition to his contribution to developing new therapies, Gianni Bonadonna played an important role in bringing highly focused, disciplined, ethical clinical trials to the European continent.
authors.affiliation: Yale Cancer Center, Yale University School of Medicine, New Haven, CT - USA.
authors.forename: Vincent T
authors.initials: VT
authors.lastname: DeVita
authors.affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA - USA.
authors.forename: George P
authors.initials: GP
authors.lastname: Canellos
mesh_terms: D000677:Amsacrine / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000266:history / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000266:history / Q000401:mortality; D002986:Clinical Trials as Topic / Q000266:history; D003299:Cooperative Behavior; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000266:history; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000266:history / Q000401:mortality; D006801:Humans; D007558:Italy; D015993:Life Tables; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000266:history / Q000401:mortality; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage / Q000266:history; D008495:Medical Oncology / Q000266:history*; D008727:Methotrexate / Q000008:administration & dosage / Q000266:history; D054547:National Cancer Institute (U.S.); D011241:Prednisone / Q000008:administration & dosage / Q000266:history; D011344:Procarbazine / Q000008:administration & dosage / Q000266:history; D014481:United States; D014750:Vincristine / Q000008:administration & dosage / Q000266:history
chemical_list: D000677:Amsacrine; D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil; D011241:Prednisone; D008727:Methotrexate