title: Trends in brain-dead organ donor characteristics: a 13-year analysis.
abstract: BACKGROUND
  Driven by disease trends, such as obesity and metabolic syndrome, that are increasingly prevalent in the general population, we aimed to evaluate the comorbidities and attributes of the brain-dead organ donor population over time in a longitudinal study.
  
  
  METHODS
  We compared overall health and baseline attributes of organ donors between 2000-2005 and 2006-2012 using our prospective transplant database. Descriptive and comparative analyses of the 2 historical cohorts were performed.
  
  
  RESULTS
  A total of 1040 brain-dead organ donors were included in our analysis: 496 from the 2000-2005 period and 544 from the 2006-2012 period. Our analysis revealed that donors from the recent (2006-2012) period were more likely to have increased body mass index (26.4 ± 6.0 v. 25.0 ± 4.8, p = 0.003), smoking history (57.0% v. 27.2%, p < 0.001), coronary artery disease (14.3% v. 3.2%, p = 0.015) and dyslipidemia (19.1% v. 4.2%, p < 0.001), but less likely to have concurrent infection (1.1% v. 7.9%, p < 0.001) than those from the earlier period.
  
  
  CONCLUSIONS
  Our data suggest that the characteristics and comorbidities of brain-dead organ donors have somewhat deteriorated over the last decade. Further studies are needed to evaluate the impact of these health attributes on donated organ utilization and outcomes.
authors.affiliation: From the Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, Que. (Hassanain, Aloraini, Metrakos); the Department of Surgery, King Saud University, Riyadh, Saudi Arabia (Hassanain, Madkhali); the Research School of Population Health, Australian National University, Canberra, Australia (Doi); and the Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia (Aljiffry).
authors.forename: Mazen
authors.initials: M
authors.lastname: Hassanain
authors.affiliation: From the Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, Que. (Hassanain, Aloraini, Metrakos); the Department of Surgery, King Saud University, Riyadh, Saudi Arabia (Hassanain, Madkhali); the Research School of Population Health, Australian National University, Canberra, Australia (Doi); and the Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia (Aljiffry).
authors.forename: Eve
authors.initials: E
authors.lastname: Simoneau
authors.affiliation: From the Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, Que. (Hassanain, Aloraini, Metrakos); the Department of Surgery, King Saud University, Riyadh, Saudi Arabia (Hassanain, Madkhali); the Research School of Population Health, Australian National University, Canberra, Australia (Doi); and the Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia (Aljiffry).
authors.forename: Suhail A
authors.initials: SA
authors.lastname: Doi
authors.affiliation: From the Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, Que. (Hassanain, Aloraini, Metrakos); the Department of Surgery, King Saud University, Riyadh, Saudi Arabia (Hassanain, Madkhali); the Research School of Population Health, Australian National University, Canberra, Australia (Doi); and the Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia (Aljiffry).
authors.forename: Murad
authors.initials: M
authors.lastname: Aljiffry
authors.affiliation: From the Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, Que. (Hassanain, Aloraini, Metrakos); the Department of Surgery, King Saud University, Riyadh, Saudi Arabia (Hassanain, Madkhali); the Research School of Population Health, Australian National University, Canberra, Australia (Doi); and the Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia (Aljiffry).
authors.forename: Abdulla
authors.initials: A
authors.lastname: Aloraini
authors.affiliation: From the Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, Que. (Hassanain, Aloraini, Metrakos); the Department of Surgery, King Saud University, Riyadh, Saudi Arabia (Hassanain, Madkhali); the Research School of Population Health, Australian National University, Canberra, Australia (Doi); and the Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia (Aljiffry).
authors.forename: Ahmad
authors.initials: A
authors.lastname: Madkhali
authors.affiliation: From the Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, Que. (Hassanain, Aloraini, Metrakos); the Department of Surgery, King Saud University, Riyadh, Saudi Arabia (Hassanain, Madkhali); the Research School of Population Health, Australian National University, Canberra, Australia (Doi); and the Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia (Aljiffry).
authors.forename: Peter
authors.initials: P
authors.lastname: Metrakos
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001926:Brain Death; D015897:Comorbidity; D050171:Dyslipidemias / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011792:Quebec / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology*; D014019:Tissue Donors / Q000706:statistics & numerical data*