title: Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer.
abstract: A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
authors.affiliation: Parker H. Petit Institute for Bioengineering and Bioscience, G. W. Woodruff School of Mechanical Engineering and School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0295, USA.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Hasani-Sadrabadi
authors.affiliation: Department of Chemical Engineering, Monash University, Melbourne, VIC, 3168, Australia.|Laboratory for Biomedical Engineering/Fluids, Laboratory for Aeronautical and Industrial Research, Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3168, Australia.
authors.forename: Shahrouz
authors.initials: S
authors.lastname: Taranejoo
authors.affiliation: Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, 53201, USA.
authors.forename: Erfan
authors.initials: E
authors.lastname: Dashtimoghadam
authors.affiliation: Department of Chemical Engineering, Amirkabir University of Technology, Tehran, 49417-15344, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Bahlakeh
authors.affiliation: Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
authors.forename: Fatemeh Sadat
authors.initials: FS
authors.lastname: Majedi
authors.affiliation: Laboratoire de Microsystemes (LMIS4), Institute of Microengineering and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
authors.forename: Jules John
authors.initials: JJ
authors.lastname: VanDersarl
authors.affiliation: Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17444, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Janmaleki
authors.affiliation: Department of Mechanical Engineering, Sharif University of Technology, Tehran, 11365-11155, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sharifi
authors.affiliation: Laboratoire de Microsystemes (LMIS4), Institute of Microengineering and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bertsch
authors.affiliation: Department of Chemical Engineering, Monash University, Melbourne, VIC, 3168, Australia.|Laboratory for Biomedical Engineering/Fluids, Laboratory for Aeronautical and Industrial Research, Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3168, Australia.
authors.forename: Kerry
authors.initials: K
authors.lastname: Hourigan
authors.affiliation: Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, 53201, USA.|Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA, 94304, USA.
authors.forename: Lobat
authors.initials: L
authors.lastname: Tayebi
authors.affiliation: Laboratoire de Microsystemes (LMIS4), Institute of Microengineering and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud
authors.affiliation: Parker H. Petit Institute for Bioengineering and Bioscience, G. W. Woodruff School of Mechanical Engineering and School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0295, USA.
authors.forename: Karl I
authors.initials: KI
authors.lastname: Jacob
mesh_terms: D003110:Colonic Neoplasms; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D044085:Microfluidics; D053758:Nanoparticles
chemical_list: D004337:Drug Carriers
keywords: cancer therapy; core-shell nanoparticles; drug delivery; microfluidics platform; stimuli-responsive release