title: The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils.
abstract: 18β-Glycyrrhetinic acid (GRA), a major component of Glycyrrhiza glabra, is widely used therapeutically in clinic. In this study, the effect of GRA on Helicobacter pylori- (H. pylori-) infected gastritis was investigated in Mongolian gerbils in vivo. The gerbils were randomly divided into groups: uninfected; H. pylori-infected; H. pylori + antibiotics (clarithromycin, amoxicillin, and esomeprazole); and H. pylori + GRA. The gastric intraluminal pH value, histopathological changes, and the expression levels of inflammation-related cytokines (IL-1β, TNF-α, COX-2, and iNOS) were investigated. The results showed that, in the H. pylori + GRA group, the intraluminal gastric pH value was lower (2.14 ± 0.08 versus 3.17 ± 0.23, P < 0.05), erosion and hyperplasia were alleviated, the infiltration of neutrophils and mononuclear cells was attenuated (P < 0.05), and the expression levels of TNF-α, IL-1β, COX-2, and iNOS were decreased (P < 0.05) compared with the H. pylori-infected group. There was no significant difference in results between the H. pylori + GRA group and the H. pylori + antibiotics group. This study indicated that GRA significantly attenuated H. pylori-infected gastritis in gerbils and has the potential to be developed as a new therapeutic drug.
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Donghui
authors.initials: D
authors.lastname: Cao
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Lili
authors.initials: L
authors.lastname: You
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Division of Pathology I, School of Medicine, Fujita Health University, Toyoake 470-1192, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsukamoto
authors.affiliation: Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Hongke
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Shidong
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Yue-er
authors.initials: YE
authors.lastname: Suo
authors.affiliation: Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Cao
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism* / Q000382:microbiology; D005849:Gerbillinae; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D016481:Helicobacter Infections / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; C119129:18alpha-glycyrrhetinic acid; D051546:Cyclooxygenase 2; D006034:Glycyrrhetinic Acid