title: Comparison of β-cell dysfunction and insulin resistance correlating obesity with type 2 diabetes: A cross-sectional study.
abstract: To assess the contribution of β-cell dysfunction and insulin resistance to type 2 diabetes (T2D) in obese and non-obese Chinese people.
  
  
  
  In this cross-sectional study, we recruited 1384 newly diagnosed T2D patients and 1712 healthy controls. Insulin resistance was estimated by homeostasis model assessment of insulin resistance (HOMA-IR). β-cell function was estimated by homeostasis model assessment of β-cell function (HOMA-β) and 60min insulinogenic index (IGI60). We compared the insulin resistance and β-cell function of obese and non-obese Chinese patients with and without T2D.
  
  
  
  50.18% of control participants and 62.28% of T2D patients were obese (BMI≥25kg/m(2)). HOMA-IR, HOMA-β and IGI60 were significantly higher in obese than non-obese, irrespective of T2D. Non-obese T2D patients had significantly greater HOMA-IR, and lower HOMA-β and IGI60 than non-obese control participants. The obese T2D group had lower HOMA-β and IGI60 than the obese control group. There was no significant difference in HOMA-IR between the obese T2D and obese control groups. Multivariate logistic regression analysis revealed that HOMA-IR was associated with T2D only in non-obese group, and HOMA-β and IGI60 were associated with T2D in both non-obese and obese groups.
  
  
  
  HOMA-β and IGI60 were associated with T2D in obese and non-obese patients, but HOMA-IR was associated with T2D in non-obese Chinese.
authors.affiliation: Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Physical Examination Center, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Yanjin
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Health Management Center, The Second Hospital of Dalian Medical University, Dalian, China.
authors.forename: Song
authors.initials: S
authors.lastname: Leng
authors.affiliation: Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China. Electronic address: drwg6688@126.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Wang
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D015994:Incidence; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007700:Kinetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D050177:Overweight / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Insulin resistance; Obesity; Type 2 diabetes; β-Cell dysfunction