title: Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans.
abstract: Two new 13-membered macrolides (1, 7), along with known 13-membered macrolides PF1163A, B, D, H, and F (2-6), were isolated from a strain of a marine-derived fungus, Penicillium meleagrinum var. viridiflavum. The structures of 1 and 7 were elucidated from spectroscopic data (NMR, MS, IR). Compounds 1-7 showed synergistic effects with fluconazole against azole-resistant Candida albicans by a checkerboard assay.
authors.affiliation: Department of Pharmacognosy and Phytochemistry and ‡Department of Microbiology, Meiji Pharmaceutical University , 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Okabe
authors.affiliation: Department of Pharmacognosy and Phytochemistry and ‡Department of Microbiology, Meiji Pharmaceutical University , 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.affiliation: Department of Pharmacognosy and Phytochemistry and ‡Department of Microbiology, Meiji Pharmaceutical University , 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.affiliation: Department of Pharmacognosy and Phytochemistry and ‡Department of Microbiology, Meiji Pharmaceutical University , 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
mesh_terms: D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004357:Drug Synergism; D015725:Fluconazole / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
chemical_list: D001393:Azoles; D018942:Macrolides; D015725:Fluconazole