title: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model.
abstract: Platelet-rich plasma (PRP) has been known to possess an efficacy in tissue regeneration. The aim of this study was to determine the role of PRP on post-operative adhesion formation in an experimental rat study.
  
  
  
  Thirty Sprague-Dawley rats were randomly divided into control, hyaluronic acid, and PRP treatment groups and operated on for uterine horn adhesion modeling. Blood was collected to produce a PRP with platelet counts of 688 × 10(3)/μL, and 1 ml of either hyaluronic acid gel or PRP was administered over the standard lesions, while the control group received no medication. The evaluation of post-operative adhesions was done on the 30th post-operative day. The location, extent, type, and tenacity of adhesions as well as total adhesion scores, tissue inflammation, fibrosis and transforming growth factor-1beta (TGF-1β) expressions were evaluated.
  
  
  
  The total adhesion score was significantly lower in the PRP group (3.2 ± 1.5) compared with the hyaluronic acid (5.0 ± 1.3) and control (8.1 ± 1.7) groups. The extent of the adhesions was significantly lower in the PRP group. There was no significant difference in the type and tenacity of adhesions between the hyaluronic acid and the PRP group. The level of inflammation was significantly higher in the control group than the others, while there was no difference between the PRP and hyaluronic acid groups. TGF-1β expression was significantly lesser in the PRP group than the control and hyaluronic acid groups.
  
  
  
  PRP is more effective than hyaluronic acid treatment in preventing post-operative adhesion formation in an experimental rat uterine horn adhesion model.
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Hamamonu, 06230, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Oz
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Hamamonu, 06230, Ankara, Turkey. cetinkayanilufer@gmail.com.
authors.forename: Nilufer
authors.initials: N
authors.lastname: Cetinkaya
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Hamamonu, 06230, Ankara, Turkey.
authors.forename: Sevda
authors.initials: S
authors.lastname: Bas
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Hamamonu, 06230, Ankara, Turkey.
authors.forename: Elmas
authors.initials: E
authors.lastname: Korkmaz
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Hamamonu, 06230, Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Ozgu
authors.affiliation: Department of General Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Gokay Serdar
authors.initials: GS
authors.lastname: Terzioglu
authors.affiliation: Department of Biochemistry, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Umran
authors.initials: U
authors.lastname: Buyukkagnici
authors.affiliation: Department of Pathology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Akbay
authors.affiliation: Department of Pathology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Caydere
authors.affiliation: Department of Obstetrics and Gynecology, Hitit University Medical Faculty, Çorum, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Gungor
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D010976:Platelet Count; D053657:Platelet-Rich Plasma; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control*; D014591:Uterine Diseases / Q000517:prevention & control*
chemical_list: D006820:Hyaluronic Acid
keywords: Experimental rat model; Platelet-rich plasma; Transforming growth factor-1β; Uterine horn adhesion model