title: Small molecule-mediated duplex formation of nucleic acids with 'incompatible' backbones.
abstract: Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30033, USA. hud@chemistry.gatech.edu.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Cafferty
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30033, USA. hud@chemistry.gatech.edu.
authors.forename: Caterina
authors.initials: C
authors.lastname: Musetti
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Keunsoo
authors.initials: K
authors.lastname: Kim
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30033, USA. hud@chemistry.gatech.edu.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Horowitz
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Ramanarayanan
authors.initials: R
authors.lastname: Krishnamurthy
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30033, USA. hud@chemistry.gatech.edu.
authors.forename: Nicholas V
authors.initials: NV
authors.lastname: Hud
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation / Q000187:drug effects*; D009696:Nucleic Acids / Q000737:chemistry*; D011370:Proflavine / Q000737:chemistry / Q000494:pharmacology*; D012313:RNA / Q000737:chemistry
chemical_list: D007364:Intercalating Agents; D009696:Nucleic Acids; D012313:RNA; D004247:DNA; D011370:Proflavine