title: Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate.
abstract: Structural and thermal data were obtained for a novel hemihydrate of 6-mercaptopurine. The hemihydrate shows increased solubility and bioavailability when compared to the monohydrate form, better stability against conversion in aqueous media than the anhydrate form, and a dehydration temperature of 240 °C, the highest of any known hydrate crystal.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. matzger@umich.edu.
authors.forename: Kortney M
authors.initials: KM
authors.lastname: Kersten
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Matzger
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry* / Q000493:pharmacokinetics*; D018360:Crystallography, X-Ray; D004355:Drug Stability; D006358:Hot Temperature; D015122:Mercaptopurine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D008958:Models, Molecular; D051381:Rats; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000964:Antimetabolites, Antineoplastic; D014867:Water; D015122:Mercaptopurine