title: Gait variability in people with neurological disorders: A systematic review and meta-analysis.
abstract: There has been growing evidence showing gait variability provides unique information about gait characteristics in neurological disorders. This study systemically reviewed and quantitatively synthesized (via meta-analysis) existing evidence on gait variability in various neurological diseases, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), cerebellar ataxia (CA), Huntington's disease (HD), multiple sclerosis (MS), and Parkinson's disease (PD). Keyword search were conducted in PubMed, Web of science, Cumulative Index to Nursing and Allied Health Literature, and Cochrane Library. Meta-analysis was performed to estimate the pooled effect size for gait variability for each neurological group. Meta-regression was performed to compare gait variability across multiple groups with neurological diseases. Gait variability of 777 patients with AD, ALS, CA, HD, MS, or PD participating in 25 studies was included in meta-analysis. All pathological groups had increased amount of gait variability and loss of fractal structure of gait dynamics compared to healthy controls, and gait variability differentiated distinctive neurological conditions. The HD groups had the highest alterations in gait variability among all pathological groups, whereas the PD, AD and MS groups had the lowest. Interventions that aim to improve gait function in patients with neurological disorders should consider the heterogeneous relationship between gait variability and neurological conditions.
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL 61801, United States. Electronic address: ymoon9@illinois.edu.
authors.forename: Yaejin
authors.initials: Y
authors.lastname: Moon
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL 61801, United States.
authors.forename: JongHun
authors.initials: J
authors.lastname: Sung
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL 61801, United States.
authors.forename: Ruopeng
authors.initials: R
authors.lastname: An
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL 61801, United States.
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Hernandez
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL 61801, United States.
authors.forename: Jacob J
authors.initials: JJ
authors.lastname: Sosnoff
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D002524:Cerebellar Ataxia / Q000503:physiopathology; D005684:Gait; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology
keywords: Gait; Meta-analysis; Neurological disease; Systematic review; Variability