title: Clinical evaluation of Varnya Gana Lepa in Vyanga (melasma).
abstract: BACKGROUND
  Vyanga type of Kshudra Roga, characterised by Niruja (painless), Shyava Varna Mandalas (bluish black patches) occurring especially on the face. The clinical features correlate with melasma, which is an acquired chronic hyperpigmentation disorder, usually seen in women of childbearing age. The drugs which constitute the Varnya Gana Lepa bestow the normal Varna (color) by virtue of their qualities and actions.
  
  
  OBJECTIVE
  To determine the efficacy of Varnya Gana Lepa in the management of Vyanga.
  
  
  METHODS
  The study was a single armed clinical trial in which total 40 patients of Vyanga belonging to the age group of 16-60 years were enrolled. Paste for external application was prepared by mixing the fine powders of 10 drugs (in equal quantity) of Varnya Gana with lukewarm water and advised to apply Lepa twice daily for 15 days on affected part. The different parameters such as skin color, lesion color, texture-dryness/oiliness, luster, number and size of the lesions, darkness, area and homogeneity of lesion, itching, burning sensation, and melasma area severity index (MASI) score were assessed.
  
  
  RESULTS
  There was statistically significant improvement in MASI scores, but in overall assessment, 64.5% patients had mild improvement. Clinical improvement was more evident in darkness parameter when compared to other parameters.
  
  
  CONCLUSIONS
  The study concludes that Varnya Gana Lepa is a safe and effective formulation in the management of Vyanga (melasma).
authors.affiliation: Department of Basic Principles, Gaur Brahman Ayurvedic College, Rohtak, Haryana, India.
authors.forename: G
authors.initials: G
authors.lastname: Pallavi
authors.affiliation: Department of Rasa Shastra and Bhaishajya Kalpana, Gaur Brahman Ayurvedic College, Rohtak, Haryana, India.
authors.forename: K L Virupaksha
authors.initials: KL
authors.lastname: Gupta
authors.affiliation: Department of Basic Principles, Government Ayurveda Medical College, Mysore, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Shreevathsa
authors.affiliation: Department of Basic Principles, Government Ayurveda Medical College, Mysore, Karnataka, India.
authors.forename: Vasudev A
authors.initials: VA
authors.lastname: Chate
authors.affiliation: Department of Panchakarma, Government Ayurveda Medical College, Mysore, Karnataka, India.
authors.forename: D L
authors.initials: DL
authors.lastname: Balakrishna
keywords: Melasma; Varnya; Varnya Gana Lepa; Vyanga