title: Two-sample tests and one-way MANOVA for multivariate biomarker data with nondetects.
abstract: Testing whether the mean vector of a multivariate set of biomarkers differs between several populations is an increasingly common problem in medical research. Biomarker data is often left censored because some measurements fall below the laboratory's detection limit. We investigate how such censoring affects multivariate two-sample and one-way multivariate analysis of variance tests. Type I error rates, power and robustness to increasing censoring are studied, under both normality and non-normality. Parametric tests are found to perform better than non-parametric alternatives, indicating that the current recommendations for analysis of censored multivariate data may have to be revised. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Statistics, Uppsala University, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Thulin
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers; D035843:Biomedical Research; D003198:Computer Simulation; D006801:Humans; D015999:Multivariate Analysis
chemical_list: D015415:Biomarkers
keywords: MANOVA; biomarker; censored data; high dimensions; nondetects; protein expression; two-sample test