title: [Anaphylaxis as part of a clinical diagnosis of mastocytosi - case demonstration].
abstract: Mastocytosis is a heterogeneous group of diseases characterized by excessive proliferation and accumulation of mast cells--in one or more organs. The number of symptoms and clinical prognosis vary depending on the disease. One of the most severe potential outcome of mastocytosis is anaphylactic shock. Early diagnosis and identification of triggers enables education and avoidance them. We describe the case of a 31-year-old woman with systemic mastocytosis (SM) without skin symptoms with multiple anaphylactic reactions, including two severe. Systemic mastocytosis was confirmed in bone marrow and genetic studies. We identify allergic triggers: latex and cefuroxime and also other non-immunological triggers as non-steroidal anti-inflammatory drugs (NSAIDs). The patient never had any allergic reaction after Hymenoptera stings. Only one result of serum tryptase was elevated. There was a need to determine the safety of antibiotic use and anesthetic drugs before cesarean. The moment when the disease was diagnosed and triggers were identifie, helped avoid further severe reactions.
authors.forename: Marcin
authors.initials: M
authors.lastname: Stobiecki
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sacha
authors.forename: Ewa
authors.initials: E
authors.lastname: Czarnobilska
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000209:etiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000276:immunology; D002444:Cefuroxime / Q000276:immunology; D004342:Drug Hypersensitivity / Q000150:complications*; D005260:Female; D006801:Humans; D020315:Latex Hypersensitivity / Q000150:complications*; D008415:Mastocytosis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002444:Cefuroxime