title: Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus - Eastern Hepatobiliary Surgical Hospital consensus statement.
abstract: Hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombus (PVTT) is associated with poor prognosis, early recurrence of HCC, and limited treatment options. Current guidelines do not have standardized diagnostic and treatment modalities, thus creating a need for a multidisciplinary treatment model for standardization of the treatment. Eastern Hepatobiliary Surgical Hospital (China) convened two working parties of experts from all the departments, to consolidate the current evidence, prevailing vision for the future, and experience of the practicing clinicians engaged in HCC management, so as to develop a consensus for PVTT diagnosis and treatment according to the GRADE system. Based on the quality of the existing evidence and the strength of recommendations, the consensus statements were categorized into 3 evidence levels (A/B/C) and 5 classes (I/II/IIa/IIb/III).The panel discussed and provided clarity on the management and research options in the field of HCC with PVTT. In addition, the panel also assessed the quality of the cited studies and assigned grades to the recommendation statements. Among the group of experts, there was excellent agreement with regard to effective diagnosis and treatment of HCC with PVTT. The recommendations of this consensus will provide guidance to physicians and clinical researchers on the effective management of HCC with PVTT.
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Shuqun
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Jiamei
authors.initials: J
authors.lastname: Yang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shen
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Wenming
authors.initials: W
authors.lastname: Cong
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Guang Shun
authors.initials: GS
authors.lastname: Yang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Hu
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Gao
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Guo
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Li
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Yefa
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Guojun
authors.initials: G
authors.lastname: Qian
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Luo
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Man
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Baohua
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Su
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Feiguo
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Shi
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Guo
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Juxian
authors.initials: J
authors.lastname: Sun
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Hongyang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Wan-Yee
authors.initials: WY
authors.lastname: Lau
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Meng-Chao
authors.initials: MC
authors.lastname: Wu
mesh_terms: D000284:Administration, Oral; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D002681:China; D006498:Hepatectomy; D006801:Humans; D007167:Immunotherapy; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008495:Medical Oncology / Q000379:methods / Q000592:standards; D008833:Microcirculation; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D011169:Portal Vein / Q000473:pathology; D011379:Prognosis; D011878:Radiotherapy / Q000379:methods; D013927:Thrombosis / Q000150:complications / Q000473:pathology; D016896:Treatment Outcome
keywords: consensus; hepatocellular carcinoma; multidisciplinary treatment; portal vein tumor thrombus; recommendations