title: The Ties that Bind (the Igh Locus).
abstract: Immunoglobulin heavy-chain locus V(D)J recombination requires a 3D chromatin organization which permits widely distributed variable (V) gene segments to contact distant diversity (D) and joining (J) gene segments. A recent study has identified key nodes in the locus interactome, paving the way for new molecular insights into how the locus is configured for recombination.
authors.affiliation: Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: krang001@mc.duke.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Krangel
mesh_terms: D000818:Animals; D002843:Chromatin / Q000276:immunology; D004742:Enhancer Elements, Genetic; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D051379:Mice; D011995:Recombination, Genetic; D014158:Transcription, Genetic / Q000235:genetics / Q000276:immunology*; D045567:VDJ Recombinases / Q000235:genetics / Q000276:immunology*
chemical_list: D002843:Chromatin; D007136:Immunoglobulins; D045567:VDJ Recombinases
keywords: V(D)J recombination; chromatin; chromosome conformation capture; immunoglobulin heavy chain