title: Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis.
abstract: Presynaptic differentiation is a critical and poorly understood step in synapse formation. Using compartmentalized culture systems that isolate axons and nascent synapses, Pinto et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509039) show that the axonal ubiquitin-proteasome system locally regulates the accumulation of ubiquitinated substrates, triggering presynaptic differentiation.
authors.affiliation: Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065.
authors.forename: Ju Youn
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065 srj2003@med.cornell.edu.
authors.forename: Samie R
authors.initials: SR
authors.lastname: Jaffrey
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006624:Hippocampus / Q000201:enzymology*; D025821:Polyubiquitin / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000201:enzymology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D057149:Ubiquitinated Proteins / Q000378:metabolism*
chemical_list: D057149:Ubiquitinated Proteins; D025821:Polyubiquitin; D046988:Proteasome Endopeptidase Complex