title: Multiple cilia suppress tumour formation.
abstract: Primary cilia are cellular structures that have important functions in development and disease. The suppression of multiciliate differentiation of choroid plexus precursors, and maintenance of a single primary cilium by Notch1, is now shown to be involved in choroid plexus tumour formation.
authors.affiliation: Johns Hopkins University School of Medicine, Departments of Pathology, Ophthalmology and Oncology, Baltimore, Maryland 21205, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Eberhart
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000235:genetics*; D016545:Choroid Plexus Neoplasms / Q000235:genetics*; D005260:Female; D053823:Hedgehog Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D051881:Receptor, Notch1 / Q000235:genetics*
chemical_list: D053823:Hedgehog Proteins; D051881:Receptor, Notch1