title: Cytosolic Innate Immune Sensing and Signaling upon Infection.
abstract: Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.
authors.affiliation: Unité des Interactions Bactéries-Cellules, Institut PasteurParis, France; Institut National de la Santé et de la Recherche Médicale, U604Paris, France; Institut National de la Recherche Agronomique, USC2020Paris, France.
authors.forename: Lilliana
authors.initials: L
authors.lastname: Radoshevich
authors.affiliation: Unité des Interactions Bactéries-Cellules, Institut PasteurParis, France; Institut National de la Santé et de la Recherche Médicale, U604Paris, France; Institut National de la Recherche Agronomique, USC2020Paris, France; Cellule Pasteur, Université Paris Diderot, Sorbonne Paris CitéParis, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Dussurget
keywords: DNA; MAVS; RNA; STING; immunity; interferon; pathogen