title: HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma.
abstract: The total amount of scientific literature has grown rapidly in recent years. Specifically, there are several million citations in the field of cancer. This makes it difficult, if not impossible, to manually retrieve relevant information on the mechanisms that govern tumor behavior or the neoplastic process. Furthermore, cancer is a complex disease or, more accurately, a set of diseases. The heterogeneity that permeates many tumors is particularly evident in head and neck (HN) cancer, one of the most common types of cancer worldwide. In this study, we present HNdb, a free database that aims to provide a unified and comprehensive resource of information on genes and proteins involved in HN squamous cell carcinoma, covering data on genomics, transcriptomics, proteomics, literature citations and also cross-references of external databases. Different literature searches of MEDLINE abstracts were performed using specific Medical Subject Headings (MeSH terms) for oral, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinomas. A curated gene-to-publication assignment yielded a total of 1370 genes related to HN cancer. The diversity of results allowed identifying novel and mostly unexplored gene associations, revealing,for example, that processes linked to response to steroid hormone stimulus are significantly enriched in genes related to HN carcinomas. Thus, our database expands the possibilities for gene networks investigation, providing potential hypothesis to be tested. Database URL:http://www.gencapo.famerp.br/hndb.
authors.affiliation: Department of Molecular Biology, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Henrique
authors.affiliation: Institute of Exact Science, Federal University of Alfenas, MG, Brazil, Rua Gabriel Monteiro da Silva, 700 Centro 37130-000 - Alfenas, MG - Brazil.
authors.forename: Nelson
authors.initials: N
authors.lastname: José Freitas da Silveira
authors.affiliation: Department of Molecular Biology, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil.
authors.forename: Arthur
authors.initials: A
authors.lastname: Henrique Cunha Volpato
authors.affiliation: Department of Dermatological, Infectious, and Parasitic Diseases, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil.
authors.forename: Mayra Mataruco
authors.initials: MM
authors.lastname: Mioto
authors.affiliation: Department of Molecular Biology, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, SP, Brazil R. do Matão Butantã 05508-090 - São Paulo, SP, Brazil.
authors.forename: Ana
authors.initials: A
authors.lastname: Carolina Buzzo Stefanini
authors.affiliation: Department of Molecular Biology, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil.
authors.forename: Adil
authors.initials: A
authors.lastname: Bachir Fares
authors.affiliation: Department of Molecular Biology, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Gustavo da Silva Castro Andrade
authors.affiliation: Department of Molecular Biology, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Masson
authors.affiliation: State of São Paulo Cancer Institute - ICESP, SP, Brazil Av. Dr. Arnaldo, 251 Pacaembu 01246-000 - São Paulo, SP - Brazil.
authors.forename: Rossana
authors.initials: R
authors.lastname: Verónica Mendoza López
authors.affiliation: Department of Stomatology School of Dentistry, University of São Paulo, SP, Brazil Avenida Professor Lineu Prestes, 2227 Butantã 05508-000 - São Paulo, SP - Brazil.
authors.forename: Fabio
authors.initials: F
authors.lastname: Daumas Nunes
authors.affiliation: Department of Head and Neck Surgery and Otorhinolaryngology, Cancer Hospital A.C. Camargo, SP, Brazil Rua Prof Antonio Prudente, 211 Liberdade 01509-010 - São Paulo, SP - Brazil and.
authors.forename: Luis
authors.initials: L
authors.lastname: Paulo Kowalski
authors.affiliation: Albert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, SP, Brazil Av. Albert Einstein, 627 Morumbi 05652-000 - São Paulo, SP - Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Severino
authors.affiliation: Department of Molecular Biology, School of Medicine of São José do Rio Preto, SP, Brazil Av Brigadeiro Faria Lima n° 5416 Vila Sao Pedro 15090-000 - São José do Rio Preto, SP - Brazil Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, SP, Brazil R. do Matão Butantã 05508-090 - São Paulo, SP, Brazil tajara@famerp.br.
authors.forename: Eloiza Helena
authors.initials: EH
authors.lastname: Tajara
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002871:Chromosome Banding; D030541:Databases, Genetic; D030562:Databases, Protein; D053263:Gene Regulatory Networks; D052138:Genes, Neoplasm; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D000077195:Squamous Cell Carcinoma of Head and Neck