title: Living Donor Liver Transplantation Outcomes for Hepatocellular Carcinoma Beyond Milan or UCSF Criteria.
abstract: Liver transplantation (LT) is the most effective treatment for hepatocellular carcinoma (HCC) that arises from cirrhosis. The Milan and the University of California, San Francisco (UCSF) selection criteria have resulted in major improvements in patient survival. We assessed our outcomes for patients with HCC that were beyond the Milan and UCSF criteria after living donor liver transplantation. We reviewed the data for 109 patients with cirrhosis and HCC who underwent living donor right lobe liver transplantation (living donor liver transplantation; LDLT) during the period from July 2004 to July 2012. Sixteen (14.7 %) patients had HCC recurrences during a mean follow-up of 35.4 ± 26.2 months (range 4-100 months). The mean time to recurrence was 11 ± 9.4 months (range 4-26 months). Survival rates were not significantly different between patients with HCC that met and were beyond the Milan and UCSF criteria (p = 0.761 and p = 0.861, respectively). The Milan and UCSF criteria were not independent risk factors for HCC recurrence or patient survival. Only poorly differentiated tumors were associated with a lower survival rate (OR = 8.656, 95 % confidence interval (CI) 2.01-37.16; p = 0.004). Survival rates for patients with HCC that were beyond conventional selection criteria should encourage reconsidering the acceptable thresholds of these criteria so that more HCC patients may undergo LT without affecting outcomes.
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Gunay
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Necdet
authors.initials: N
authors.lastname: Guler
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Yaprak
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Dayangac
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Akyildiz
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Gulum
authors.initials: G
authors.lastname: Altaca
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Yildiray
authors.initials: Y
authors.lastname: Yuzer
authors.affiliation: Liver Transplantation Center, Florence Nightingale Hospital, Abidei Hurriyet Cad. No: 164 Sisli, 34679 Istanbul, Turkey.
authors.forename: Yaman
authors.initials: Y
authors.lastname: Tokat
keywords: Hepatocellular carcinoma; Living donor liver transplantation; The Milan criteria; UCSF criteria