title: Tirofiban combined with urokinase selective intra-arterial thrombolysis for the treatment of middle cerebral artery occlusion.
abstract: The aims of the present study were to establish a model of embolic stroke in rabbits and to evaluate the efficacy and safety of intra-arterially administered tirofiban combined with urokinase thrombolysis. The middle cerebral artery occlusion model (MCAO) of embolic stroke was established in New Zealand rabbits via an autologous clot. The model rabbits were allocated at random into four groups: Tirofiban group (T group), urokinase group (UK group), tirofiban and urokinase group (T + UK group) and the control group (C group). The recanalization rate, relative-apparent diffusion coefficient (rADC) and neurological function deficit score (NFDS) values were compared among the four groups. The recanalization rate, rADC and NFDS values were improved in the T + UK group compared with the other groups. In summary, the intra-arterial administration of tirofiban combined with urokinase thrombolysis was a more effective intervention in an MCAO model compared with intra-arterial urokinase alone, and may promote reperfusion and reduce infarct volume.
authors.affiliation: Department of Neurovascular Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Neurovascular Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurovascular Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Yunzhen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurovascular Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Neurovascular Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Chunhai
authors.initials: C
authors.lastname: Su
authors.affiliation: Department of Clinical Pharmacy, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Chuanfeng
authors.initials: C
authors.lastname: Lv
authors.affiliation: Department of Neurovascular Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Wei
keywords: intracranial embolism; platelet glycoprotein IIb-IIIa complex; rabbit model; thrombolysis