title: The Roles of MDM2 and MDMX in Cancer.
abstract: For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been shown to exert oncogenic activity. These two proteins are best understood as negative regulators of the p53 tumor suppressor, although they may have additional p53-independent roles. Understanding the dysregulation of MDM2 and MDMX in human cancers and how they function either together or separately in tumorigenesis may improve methods of diagnosis and for assessing prognosis. Targeting the proteins themselves, or their regulators, may be a promising therapeutic approach to treating some forms of cancer.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY 10027; email: clp3@columbia.edu.
authors.forename: Orit
authors.initials: O
authors.lastname: Karni-Schmidt
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY 10027; email: clp3@columbia.edu.
authors.forename: Maria
authors.initials: M
authors.lastname: Lokshin
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY 10027; email: clp3@columbia.edu.
authors.forename: Carol
authors.initials: C
authors.lastname: Prives
mesh_terms: D063646:Carcinogenesis / Q000378:metabolism*; D018797:Cell Cycle Proteins; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; C482775:MDM4 protein, human; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: MDM2; MDMX; cancer; p53; tumorigenesis