title: The changes of HRV in refractory epilepsy: The potential index to predict the onset of epilepsy in children.
abstract: In this study, we examine the potential of heart rate variability (HRV) as an efficient tool for predicting the onset of epilepsy in children. We totally collected 53 seizures EEG and ECG data using Video - EEG - ECG monitoring system. We then separated the ECG data into three segments: ten-minute before onset of each seizure, five-minute before onset of each seizure, and five-minute from the onset of each seizure. After the HRV parameters in all segments were calculated, we compared the differences between pre-ictal period and ictal period. We found that the values of meanHR, LF and LF/HF were greater in onset period. And the values of meanRR and the HF were less in ictal period. And it presented the similar changes when seizures occurred in the daytime and seizures occurred in the nighttime. In brief, we found that the sympathetic nervous system was under a more active status during onset period. We speculated that the HRV parameters such as the LF, HF or LF/HF could have potential to predict the seizures in children with epilepsy.
authors.affiliation: Department of Ultrasound, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
authors.forename: Xuehao
authors.initials: X
authors.lastname: Gong
authors.affiliation: Guangzhou Medical University, Guangzhou, Guangdong, China.|Department of Thyroid and Breast Surgery, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
authors.forename: Xuhua
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Electroencephalogram Room, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Ultrasound, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.|Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Leidan
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Ultrasound, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
authors.forename: Weizong
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Ultrasound, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.|Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Department of Thyroid and Breast Surgery, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
authors.forename: Xianming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Research center for Biosensors and Medical Instruments, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Thyroid and Breast Surgery, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
mesh_terms: D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography / Q000145:classification* / Q000379:methods; D004569:Electroencephalography / Q000145:classification* / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male
keywords: HRV; Seizure; children