title: [Neurologic appearence of Behçet disease in 14-year old boy treated with adalimumab with good result].
abstract: Behçet disease is a multiorgan inflammatory vessel disorder of unknown etiology which only occasionally occurs in children. Here, we demonstrate a 14-year-old boy with Behçet disease diagnosed based on recurrent aphthous stomatitis, acneiform facial lesions, subpreputial erosions and extensive thrombosis involving sigmoid sinus, transverse sinus and right internal cervical vein. Treatment with low molecular weight heparins, systemic corticosteroids, and azathioprine only resulted in partial remission of clinical symptoms. Addition of adalimumab led to complete resolution of clinical and biochemical abnormalities and disappearance of thrombosis in central nervous system.
authors.affiliation: Medical University of Wrocław, Poland: 2nd Department and Clinic of Pediatrics, Gastroenterology and Nutrition.
authors.forename: Barbara
authors.initials: B
authors.lastname: Iwańczak
authors.affiliation: Medical University of Wrocław, Poland: Department of Dermatology, Venerology and Allergology.
authors.forename: Adam
authors.initials: A
authors.lastname: Reich
authors.affiliation: Medical University of Wrocław, Poland: 2nd Department and Clinic of Pediatrics, Gastroenterology and Nutrition.
authors.forename: Anna
authors.initials: A
authors.lastname: Kofla-Dłubacz
authors.affiliation: Medical University of Wrocław, Poland: Department and Clinic of Pediatric Oncology, Haematology and Bone Marrow Transplantation.
authors.forename: Bernarda
authors.initials: B
authors.lastname: Kazanowska
authors.affiliation: Medical University of Wrocław, Poland: 2nd Department and Clinic of Pediatrics, Gastroenterology and Nutrition.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Ruczka
mesh_terms: D017486:Acneiform Eruptions / Q000188:drug therapy; D000068879:Adalimumab / Q000627:therapeutic use*; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D002490:Central Nervous System / Q000187:drug effects; D004359:Drug Therapy, Combination; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013281:Stomatitis, Aphthous / Q000188:drug therapy; D013927:Thrombosis / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D006495:Heparin, Low-Molecular-Weight; D000068879:Adalimumab; D001379:Azathioprine
keywords: Behçet disease; children; neurological form