title: MicroRNA: A new therapeutic strategy for cardiovascular diseases.
abstract: Myocardial infarction, atherosclerosis, and hypertension are the most common heart-related diseases that affect both the heart and the blood vessels. Multiple independent risk factors have been shown to be responsible for cardiovascular diseases. The combination of a healthy diet, exercise, and smoking cessation keeps these risk factors in check and helps maintain homeostasis. The dynamic monolayer endothelial cell integrity and cell-cell communication are the fundamental mechanisms in maintaining homeostasis. Recently, it has been revealed that small noncoding RNAs (ncRNAs) play a critical role in regulation of genes involved in either posttranscriptional or pretranslational modifications. They also control diverse biological functions like development, differentiation, growth, and metabolism. Among ncRNAs, the short interfering RNAs (siRNAs), and microRNAs (miRNAs) have been extensively studied, but their specific functions remain largely unknown. In recent years, miRNAs are efficiently studied as one of the important candidates for involvement in most biological processes and have been implicated in many human diseases. Thus, the identification and the respective targets of miRNAs may provide novel molecular insight and new therapeutic strategies to treat diseases. This review summarizes the recent developments and insight on the role of miRNAs in cardiovascular disease prognosis, diagnostic and clinical applications.
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS.
authors.forename: Saheli
authors.initials: S
authors.lastname: Samanta
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS; Centre for Biotechnology, Anna University, Chennai, Tamil Nadu, India.
authors.forename: Sathyamoorthy
authors.initials: S
authors.lastname: Balasubramanian
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS.
authors.forename: Sheeja
authors.initials: S
authors.lastname: Rajasingh
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS.
authors.forename: Urmi
authors.initials: U
authors.lastname: Patel
authors.affiliation: Centre for Biotechnology, Anna University, Chennai, Tamil Nadu, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Dhanasekaran
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS.
authors.forename: Buddhadeb
authors.initials: B
authors.lastname: Dawn
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS. Electronic address: rjohnson9@kumc.edu.
authors.forename: Johnson
authors.initials: J
authors.lastname: Rajasingh
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D005786:Gene Expression Regulation; D005819:Genetic Markers; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D025202:Molecular Diagnostic Techniques; D011237:Predictive Value of Tests; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs
keywords: Atherosclerosis; Cardiac fibrosis; Endothelial cells; Hypertension; MicroRNAs; Myocardial infarction; Stroke