title: Identification of anterior chamber angle parameters with a portable SD-OCT device compared to a non-portable SD-OCT.
abstract: The aim of this study is to compare a portable spectral domain optical coherence tomography (SD-OCT) device with a non-portable SD-OCT for the identification of anterior chamber angle parameters based on location of Schwalbe's line (SL) and to measure their reproducibility. 99 eyes from 46 normal, healthy participants underwent imaging of the inferior iridocorneal angle with the iVue and Cirrus SD-OCT under well-controlled low-light conditions. SL-angle opening distance (SL-AOD) and SL-trabecular iris space area (SL-TISA) were measured by masked, certified graders at the Doheny Image Reading Center using customized Image J grading software. Inter- and intrainstrument, as well as inter- and intraobserver reproducibility of SL-AOD and SL-TISA measurements were evaluated with intraclass correlation coefficients (ICCs) and Bland-Altman plots with limits of agreement. The mean SL-AOD was 0.814 ± 0.315 mm with the iVue and 0.797 ± 0.294 mm with the Cirrus. The mean SL-TISA was 0.247 ± 0.112 mm2with iVue and 0.259 ± 0.113 mm2with Cirrus. Interinstrument correlation coefficients (r) were 0.93 (P < 0.0001), 0.92 (P < 0.0001), and 0.92 (P < 0.0001) for SL_AOD and SL_TISA, respectively. Intraclass correlation coefficient showing the degree of agreement among SL-AOD and SL-TISA was 0.923 (95 % confidence interval 0.885-0.948) and 0.921 (95 % confidence interval 0.883-0.947) for both devices. The agreement for intrainstrument (ICCs > 0.95), intragrader (ICCs > 0.93), and intergrader (ICCs > 0.96) was excellent. Excellent agreement between the two devices was also documented with Bland-Altman analysis. Both instruments provide consistent and reproducible measurements of anterior chamber angle metrics.
authors.affiliation: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA. handanakil84@gmail.com.
authors.forename: Handan
authors.initials: H
authors.lastname: Akil
authors.affiliation: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Marion
authors.affiliation: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Dastiridou
authors.affiliation: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Jenkins
authors.affiliation: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
authors.forename: Brendan
authors.initials: B
authors.lastname: Kramer
authors.affiliation: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.|Department of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Francis
authors.affiliation: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.|Department of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Chopra
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007498:Iris / Q000033:anatomy & histology*; D008297:Male; D015588:Observer Variation; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods
keywords: Agreement; Anterior chamber angle; Anterior segment OCT; Glaucoma; Optical coherence tomography; Reproducibility; Schwalbe’s line