title: Designing tragacanth gum based sterile hydrogel by radiation method for use in drug delivery and wound dressing applications.
abstract: Present article discusses synthesis and characterization of the sterile and pure hydrogel wound dressings which were prepared through radiation method by using polyvinyl alcohol (PVA), tragacanth gum (TG) and sodium alginate (SA). The polymer films were characterized by SEM, Cryo-SEM, FTIR, solid state C(13) NMR and XRD, TGA, and DSC. Some important biological properties such as O2 permeability, water vapor transmission rate, microbial permeability, haemolysis, thrombogenic behavior, antioxidant activity, bio-adhesion and mechanical properties were also studied. The hydrogel film showed thrombogenicity (82.43±1.54%), haemolysis (0.83±0.09%), oxygen permeability (6.433±0.058mg/L) and water vapor permeability (197.39±25.34g/m(2)/day). Hydrogel films were found biocompatible and impermeable to microbes. The release of antibiotic drug moxifloxacin occurred through non-Fickian mechanism and release profile was best fitted in Hixson-Crowell model for drug release. Overall, these results indicate the suitability of these hydrogels in wound dressing applications.
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla 171005, India. Electronic address: baljitsinghhpu@yahoo.com.
authors.forename: Baljit
authors.initials: B
authors.lastname: Singh
authors.affiliation: Radiation Technology Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India.
authors.forename: Lalit
authors.initials: L
authors.lastname: Varshney
authors.affiliation: Radiation Technology Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India.
authors.forename: Sanju
authors.initials: S
authors.lastname: Francis
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
authors.lastname: Rajneesh
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use; D010100:Oxygen / Q000737:chemistry; D010539:Permeability / Q000187:drug effects; D011827:Radiation; D014144:Tragacanth / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use; D058106:Wound Closure Techniques
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D006603:Hexuronic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid; D014144:Tragacanth; D010100:Oxygen
keywords: Drug delivery; Hydrogel; Moxifloxacin; Mucoadhesion; Wound dressing