title: Impact of antenatal steroids on intraventricular hemorrhage in very-low-birth weight infants.
abstract: To determine the association between antenatal steroids administration and intraventricular hemorrhage rates.
  
  
  
  We used cross-sectional data from the California Perinatal Quality Care Collaborative during 2007 to 2013 for infants ⩽32 weeks gestational age. Using multivariable logistic regression, we evaluated the effect of antenatal steroids on intraventricular hemorrhage, stratified by gestational age.
  
  
  
  In 25 979 very-low-birth weight infants, antenatal steroid use was associated with a reduction in incidence of any grade of intraventricular hemorrhage (odds ratio=0.68, 95% confidence interval: 0.62, 0.75) and a reduction in incidence of severe intraventricular hemorrhage (odds ratio=0.51, 95% confidence interval: 0.45, 0.58). This association was seen across gestational ages ranging from 22 to 29 weeks.
  
  
  
  Although current guidelines recommend coverage for preterm birth at 24 to 34 weeks gestation, our results suggest that treatment with antenatal steroids may be beneficial even before 24 weeks of gestational age.
authors.affiliation: University of California, Berkeley School of Public Health, Berkeley, CA, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Wei
authors.affiliation: University of California, Berkeley School of Public Health, Berkeley, CA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Catalano
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.|California Perinatal Quality Care Collaborative, Palo Alto, CA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Profit
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.|California Perinatal Quality Care Collaborative, Palo Alto, CA, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Gould
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.|California Perinatal Quality Care Collaborative, Palo Alto, CA, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
mesh_terms: D002140:California / Q000453:epidemiology; D000074042:Cerebral Intraventricular Hemorrhage / Q000175:diagnosis / Q000517:prevention & control; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000517:prevention & control; D019102:Infant, Very Low Birth Weight / Q000502:physiology*; D010043:Outcome and Process Assessment, Health Care; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology / Q000503:physiopathology; D011295:Prenatal Care / Q000379:methods*; D011379:Prognosis; D011787:Quality of Health Care; D012720:Severity of Illness Index
chemical_list: D005938:Glucocorticoids