title: Coagulation factors in whole blood collected from pregnant women and stored at 4°C.
abstract: The present study aimed to measure the levels of coagulation factors in stored whole blood of pregnant women and to determine their usefulness in treating pregnant women who developed coagulopathy. A prospective study to measure coagulation factors in stored donated whole blood from pregnant and non-pregnant women was conducted. Fibrinogen, FV, FVII, FVIII, FXIII, and von Willebrand factor were measured in blood stored at 4°C for 0, 1, 3, and 5 weeks. All coagulation factors except for factor XIII decreased during storage. Fibrinogen and factor VII in the blood collected from pregnant women gradually decreased over time and their levels were significantly higher after 5 weeks of storage than those of non-pregnant women at week 0. Whole blood donated by pregnant women for autologous blood transfusion and stored at 4°C may be expected being effectively for the prevention of coagulopathy and the treatment of circulatory blood volume loss.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Minatoguchi
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Itakura
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Miki
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kajihara
authors.affiliation: Department of Laboratory Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Sasaki
authors.affiliation: Department of Laboratory Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Takase
authors.affiliation: Department of Transfusion and Cell Therapy, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Department of Transfusion and Cell Therapy, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Rumiko
authors.initials: R
authors.lastname: Asada
authors.affiliation: Department of Laboratory Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan; Department of Transfusion and Cell Therapy, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ikebuchi
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishihara
mesh_terms: D001779:Blood Coagulation Factors; D001793:Blood Preservation; D003080:Cold Temperature; D005260:Female; D005340:Fibrinogen; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D001779:Blood Coagulation Factors; D005340:Fibrinogen
keywords: autologous blood transfusion; coagulopathy; fibrinogen; obstetric hemorrhage; whole blood