title: Prolactin and macroprolactin levels in psychiatric patients receiving atypical antipsychotics: A preliminary study.
abstract: The aims of this study were to clarify whether atypical antipsychotics can elevate serum levels of both macroprolactin and prolactin, and whether the macroprolactin levels differ according to the type of atypical antipsychotic being taken. In total, 245 subjects were enrolled consecutively in 6 hospitals. Serum prolactin and macroprolactin levels were measured at a single time point during maintenance antipsychotic monotherapy. The mean total serum prolactin levels including macroprolactin were 11.91, 20.73, 16.41, 50.83, 12.84, and 59.1ng/mL for patients taking aripiprazole, blonanserin, olanzapine, paliperidone, quetiapine, and risperidone, respectively, while those for macroprolactin were 1.71, 3.86, 3.73, 7.28, 2.77, and 8.0ng/mL. The total prolactin and macroprolactin levels were significantly higher among those taking paliperidone and risperidone than among those taking any of the other antipsychotics (p<0.01). Moreover, there was a strong positive correlation between serum levels of prolactin and macroprolactin. Sexual dysfunction was reported in 35.5% (87/245) of the total subjects. However, the total prolactin level did not differ significantly between subjects with and without sexual dysfunction except gynecomastia. These findings suggest that treatment with risperidone and paliperidone can induce hyperprolactinemia and macroprolactinemia in psychiatric patients.
authors.affiliation: Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Republic of Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Park
authors.affiliation: Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Republic of Korea; Clinical Emotion and Cognition Research Laboratory, Republic of Korea. Electronic address: lshpss@hanmail.net.
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Seoul Eunpyeong Hospital, Republic of Korea.
authors.forename: Bun-Hee
authors.initials: BH
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Eulji University School of Medicine, Eulji General Hospital, Republic of Korea.
authors.forename: Kyu Young
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Incheon Chamsarang Hospital, Republic of Korea.
authors.forename: Kye-Seong
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Gachon University, School of Medicine, Republic of Korea.
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.affiliation: Department of Psychiatry, College of Medicine, Soonchunhyang University, Republic of Korea.
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Seoul Paik Hospital, College of Medicine, Inje University, Republic of Korea.
authors.forename: Won
authors.initials: W
authors.lastname: Kim
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood* / Q000139:chemically induced*; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D008875:Middle Aged; D000068882:Paliperidone Palmitate / Q000009:adverse effects*; D011388:Prolactin / Q000097:blood* / Q000187:drug effects; D018967:Risperidone / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; C060678:prolactin, polymeric; D011388:Prolactin; D018967:Risperidone; D000068882:Paliperidone Palmitate
keywords: Atypical-antipsychotic-induced hyperprolactinemia; Macroprolactin; Macroprolactinemia; Prolactin