title: [Analysis of clinical factors for the efficacy of TPF in treating hypopharyngeal carcinoma].
abstract: OBJECTIVE
  To summarize the clinical effect of TPF regimen in the treatment of hypopharyngeal carcinoma and explore various clinical factors affecting treatment efficacy.
  
  
  METHODS
  The clinical data of 20 cases with hypopharyngeal carcinoma, who received TPF treatment, were analyzed retrospectively. After two courses of chemotherapy, based on radiographic outcomes, next treatment plan was developed. To sum up the clinical information, including the clinical type, patterns of tumor growth, pathologic type, tumor stage, lymph node metastasis, age and so on. To analyze possible influencing factors affecting curative effect.
  
  
  RESULTS
  (1) After 20 cases with hypopharyngeal carcinoma received two courses of TPF treatment, the effect was evaluated. Objective response rate was 65%. (2) In patients with hypopharyngeal carcinoma, the efficacy of TPF therapy was significantly related to the clinical type, patterns of tumor growth and pathologic type; there was no statistical significance in tumor stage, lymph node metastasis and age.
  
  
  CONCLUSIONS
  According to the clinical type, patterns of tumor growth and pathologic type of hypopharyngeal carcinoma, resistance to chemotherapy in hypopharyngeal carcinoma can be assessed, which provides important basis for designing individualized treatment plan.
authors.forename: Lianhe
authors.initials: L
authors.lastname: Li
authors.forename: Fuxian
authors.initials: F
authors.lastname: Tan
authors.forename: Wenhui
authors.initials: W
authors.lastname: Yue
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wang
authors.forename: Hongmin
authors.initials: H
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Xue
authors.forename: Zhenlei
authors.initials: Z
authors.lastname: Wen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000628:therapy*; D008207:Lymphatic Metastasis; D012189:Retrospective Studies; D043823:Taxoids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D043823:Taxoids; D002945:Cisplatin; D005472:Fluorouracil