title: Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin.
abstract: Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin nanoencapsulation and aerosol delivery using a commercial, hand-held nebulizer modified with a nitrogen stream.
authors.affiliation: School of Pharmaceutical Sciences of Ribeirão Preto, Ribeirao Preto, SP, Brazil; Department of Chemistry, Clemson University, Clemson, SC 29634, USA.
authors.forename: Aline A
authors.initials: AA
authors.lastname: Ishikawa
authors.affiliation: Department of Physics and Astronomy, UT San Antonio, San Antonio, TX, USA.
authors.forename: Jesus V
authors.initials: JV
authors.lastname: Salazar
authors.affiliation: Department of Chemistry, UT San Antonio, San Antonio, TX, USA.
authors.forename: Magaly
authors.initials: M
authors.lastname: Salinas
authors.affiliation: School of Pharmaceutical Sciences of Ribeirão Preto, Ribeirao Preto, SP, Brazil.
authors.forename: Cristiane M
authors.initials: CM
authors.lastname: Gaitani
authors.affiliation: Department of Physiology & Pharmacology, Center for Cardiovascular & Respiratory Sciences, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Nurkiewicz
authors.affiliation: Department of Chemistry, UT San Antonio, San Antonio, TX, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Negrete
authors.affiliation: Department of Chemistry, Clemson University, Clemson, SC 29634, USA.
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Garcia