title: Colored lenses suppress blue light-emitting diode light-induced damage in photoreceptor-derived cells.
abstract: Blue light-emitting diodes (LEDs) in liquid crystal displays emit high levels of blue light, exposure to which is harmful to the retina. Here, we investigated the protective effects of colored lenses in blue LED light-induced damage to 661W photoreceptor-derived cells. We used eight kinds of colored lenses and one lens that reflects blue light. Moreover, we evaluated the relationship between the protective effects of the lens and the transmittance of lens at 464 nm. Lenses of six colors, except for the SY, PN, and reflective coating lenses, strongly decreased the reduction in cell damage induced by blue LED light exposure. The deep yellow lens showed the most protective effect from all the lenses, but the reflective coating lens and pink lens did not show any effects on photoreceptor-derived cell damage. Moreover, these results were correlated with the lens transmittance of blue LED light (464 nm). These results suggest that lenses of various colors, especially deep yellow lenses, may protect retinal photoreceptor cells from blue LED light in proportion to the transmittance for the wavelength of blue LED and the suppression of reactive oxygen species production and cell damage.
authors.affiliation: Gifu Pharmaceutical University, Molecular Pharmacology, Department of Biofunctional Evaluation, 1-25-4 Daigakunishi, Gifu 501-1196, Japan.
authors.forename: Kaho
authors.initials: K
authors.lastname: Hiromoto
authors.affiliation: Gifu Pharmaceutical University, Molecular Pharmacology, Department of Biofunctional Evaluation, 1-25-4 Daigakunishi, Gifu 501-1196, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kuse
authors.affiliation: Gifu Pharmaceutical University, Molecular Pharmacology, Department of Biofunctional Evaluation, 1-25-4 Daigakunishi, Gifu 501-1196, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsuruma
authors.affiliation: HOYA Corporation, VC Section, CS Support Division, Japan Headquarters, 4-10-2 Nakano, Nakanoku, Tokyo 164-8545, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tadokoro
authors.affiliation: HOYA Corporation, VC Section, CS Support Division, Japan Headquarters, 4-10-2 Nakano, Nakanoku, Tokyo 164-8545, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kaneko
authors.affiliation: Gifu Pharmaceutical University, Molecular Pharmacology, Department of Biofunctional Evaluation, 1-25-4 Daigakunishi, Gifu 501-1196, Japan.
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Shimazawa
authors.affiliation: Gifu Pharmaceutical University, Molecular Pharmacology, Department of Biofunctional Evaluation, 1-25-4 Daigakunishi, Gifu 501-1196, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hara
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D002478:Cells, Cultured; D003116:Color; D005135:Eye Protective Devices; D008027:Light; D051379:Mice; D008962:Models, Theoretical; D020419:Photoreceptor Cells, Vertebrate / Q000528:radiation effects*; D017382:Reactive Oxygen Species / Q000032:analysis
chemical_list: D017382:Reactive Oxygen Species