title: Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups.
abstract: α-Helix proteomimetics represent an emerging class of ligands that can be used to inhibit an array of helix mediated protein-protein interactions. Within this class of inhibitor, aromatic oligobenzamide foldamers have been widely and successfully used. This manuscript describes alternative syntheses of these compounds that can be used to access mimetics that are challenging to synthesize using previously described methodologies, permitting access to compounds functionalized with multiple sensitive side chains and accelerated library assembly through late stage derivatisation.
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK. a.j.wilson@leeds.ac.uk and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK.
authors.forename: George M
authors.initials: GM
authors.lastname: Burslem
authors.affiliation: Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK and School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
authors.forename: Hannah F
authors.initials: HF
authors.lastname: Kyle
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK. a.j.wilson@leeds.ac.uk and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK.
authors.forename: Panchami
authors.initials: P
authors.lastname: Prabhakaran
authors.affiliation: Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK and School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK and Discovery Sciences, AstraZeneca R&D, Alderley Park, Cheshire, SK10 4TG, UK.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Breeze
authors.affiliation: Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK and School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Edwards
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK. a.j.wilson@leeds.ac.uk and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK.
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Warriner
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK. a.j.wilson@leeds.ac.uk and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Nelson
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK. a.j.wilson@leeds.ac.uk and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wilson
mesh_terms: D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D032701:Biomimetics / Q000379:methods; D008958:Models, Molecular; D017510:Protein Folding; D017433:Protein Structure, Secondary
chemical_list: D001549:Benzamides; C037689:benzamide