title: Pancreatic metastasis from mycosis fungoides mimicking primary pancreatic tumor.
abstract: Mycosis fungoides (MF) is a cutaneous T-cell lymphoma that can undergo local progression with possible systemic dissemination. We report a case of a patient affected by MF with a pancreatic mass that was a diagnostic challenge between primitive tumor and pancreatic metastasis from MF. Clinical setting findings and imaging studies raised the suspicion of a pancreatic primary neoplasm. A diagnostic clue was provided by the combined histomorphologic/immunohistochemical study of pancreatic and cutaneous biopsies, which revealed a pancreatic localization of MF. Considering the rarity of metastatic localization of MF to the pancreas, we next investigated whether chemokine-chemokine receptor interactions could be involved in the phenomenon to provide new insight into the possible mechanisms underlying metastatic localization of MF to the pancreas. Histological analyses of archival pancreatic tissue demonstrated that glucagon-secreting cells of the pancreatic islets expressed the CCL27 chemokine, which may have attracted in our case metastatic MF cells expressing the complementary receptor CCR10.
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Ceriolo
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Fausti
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Cinotti
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bonadio
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Lizzia
authors.initials: L
authors.lastname: Raffaghello
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Bianchi
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Giulio Fraternali
authors.initials: GF
authors.lastname: Orcioni
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Fiocca
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Rongioletti
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
authors.affiliation: Paola Ceriolo, Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa, 16132 Genoa, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Borgonovo
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: CCL27, CCR10; Differential diagnosis; Extracutaneous localization; Mycosis fungoides; Pancreatic mass