title: Long-term prognostic significance of homocysteine in middle-aged and elderly.
abstract: OBJECTIVE
  We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.
  
  
  METHODS
  Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.
  
  
  RESULTS
  Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.
  
  
  CONCLUSIONS
  Increased levels of Hcy are associated with all-cause mortality and CV events.
authors.affiliation: a Copenhagen University Hospital of Bispebjerg , Copenhagen , NV , Denmark.
authors.forename: Julie Falkenberg
authors.initials: JF
authors.lastname: Petersen
authors.affiliation: a Copenhagen University Hospital of Bispebjerg , Copenhagen , NV , Denmark.
authors.forename: Bjørn Strøjer
authors.initials: BS
authors.lastname: Larsen
authors.affiliation: a Copenhagen University Hospital of Bispebjerg , Copenhagen , NV , Denmark.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Sabbah
authors.affiliation: a Copenhagen University Hospital of Bispebjerg , Copenhagen , NV , Denmark.
authors.forename: Olav Wendelboe
authors.initials: OW
authors.lastname: Nielsen
authors.affiliation: a Copenhagen University Hospital of Bispebjerg , Copenhagen , NV , Denmark.
authors.forename: Preman
authors.initials: P
authors.lastname: Kumarathurai
authors.affiliation: a Copenhagen University Hospital of Bispebjerg , Copenhagen , NV , Denmark.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Sajadieh
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D006710:Homocysteine
keywords: All-cause mortality; cardiovascular disease; plasma homocysteine