title: KRABs RegulaTE Gene Expression beyond the Embryo.
abstract: Transposable element (TE) silencing is initiated early in mammalian development and maintained during somatic differentiation. Reporting in this issue of Developmental Cell, Ecco et al. (2016) show that in somatic tissues, TE regulation, and its subsequent effect on host gene transcription, is dynamic rather than locked in a silent state.
authors.affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Playfoot
authors.affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address: ian.adams@igmm.ed.ac.uk.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Adams
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements / Q000235:genetics*; D006801:Humans; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism*; D016335:Zinc Fingers / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D012097:Repressor Proteins