title: Cytokinin Synthesis, Signaling, and Function--Advances and New Insights.
abstract: The plant hormones referred to as cytokinins are chemical signals that control numerous developmental processes throughout the plant life cycle, including gametogenesis, root meristem specification, vascular development, shoot and root growth, meristem homeostasis, senescence, and more. In addition, they mediate responses to environmental cues such as light, stress, and nutrient conditions. The core mechanistics of cytokinin metabolism and signaling have been elucidated, but more layers of regulation, additional functions, and interactions with other signals are continuously discovered and described. In this chapter, we recapitulate the highlights of over 100 years of cytokinin research covering its isolation, the elucidation of phosphorelay signaling, and how cytokinin functions in various developmental contexts including its interaction with other pathways. Additionally, given cytokinin's paracrine signaling mechanism, we postulate that cellular exporters for cytokinins exist.
authors.affiliation: Department of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich Zurich, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Zürcher
authors.affiliation: Department of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich Zurich, Switzerland. Electronic address: bruno.mueller@uzh.ch.
authors.forename: B
authors.initials: B
authors.lastname: Müller
mesh_terms: D003583:Cytokinins / Q000096:biosynthesis*; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D063245:Plant Development / Q000235:genetics; D010937:Plant Growth Regulators / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D003583:Cytokinins; D010937:Plant Growth Regulators
keywords: cytokinin; hormones; phosphorelay signaling; plant development