title: Expression of β-catenin and its correlation with metastatic progression of esophagogastric junction adenocarcinoma.
abstract: The evaluation of β-catenin expression in adenocarcinoma of the esophagogastric junction and its influence on cancer progression. Sixty-one patients who were diagnosed with adenocarcinoma of the esophagogastric junction were examined. We evaluated β-catenin distribution in the cell membrane and the cell nucleus in adenocarcinoma of the esophagogastric junction type 1 and type 3. Our findings showed lack of a statistically significant difference in evaluation of adenocarcinoma type 1 and type 3 aggressiveness. However, we found a statistically significant association with the T and N stage, although we did not find an effect of them on patient survival. Patients with cellular membrane and cell nucleus staining comprise a group of patients with higher risk of malignancy progression in adenocarcinoma of the esophagogastric junction types 1 and 3.
authors.affiliation: Janusz Włodarczyk, Department of Thoracic Surgery, Jagiellonian University Collegium Medicum, Krakow, Poland, e-mail: jr.wlodarczyk@gmail.com.
authors.forename: Janusz
authors.initials: J
authors.lastname: Wlodarczyk
authors.forename: Lucyna
authors.initials: L
authors.lastname: Rudnicka-Sosin
authors.forename: Jarosław
authors.initials: J
authors.lastname: Kużdżał
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051176:beta Catenin