title: Preventive Effect of Ethyl Pyruvate on Postoperative Adhesion Formation Following Abdominal Surgery.
abstract: OBJECTIVE
  Postoperative adhesions are among the major causes of morbidity and mortality following abdominal surgery. As an antioxidant and antiinflamatory agent, the potential effect of ethyl pyruvate on adhesion prevention has not been clearly studied. We aimed to investigate the possible anti-adhesive effect of ethyl pyruvate compared with an effective barrier membrane, Seprafilm, in a rat cecal abrasion model.
  
  
  METHODS
  Male Wistar albino rats separated into three adhesion model groups (n = 8, each) with applications of different agents during surgery: control (intraperitoneal normal saline), Seprafilm group (intraperitoneal Seprafilm), and Ethyl pyruvate group (40 mg/kg intraperitoneal ethyl pyruvate). Postoperative adhesion was graded both macroscopically and histopathologically. Malondialdehyde and nitric oxide levels were determined from tissue samples for assessment of oxidative stress.
  
  
  RESULTS
  Seprafilm and Ethyl pyruvate groups had lower adhesion scores (both macroscopic and microscopic) and decreased malondialdehyde and nitric oxide levels compared to the control group (p < 0.05 for all parameters). The results were comparable for both Seprafilm and Ethyl pyruvate groups for all parameters (p > 0.05).
  
  
  CONCLUSIONS
  Intraperitoneal ethyl pyruvate application reduced the incidence and the extent of postoperative adhesions in rat cecal abrasion model. Ethyl pyruvate also had comparable overall efficacy for adhesion prevention as Seprafilm.
authors.affiliation: a Department of General Surgery , Faculty of Medicine, Istanbul Medeniyet University , Istanbul , Turkey.
authors.forename: Tarik
authors.initials: T
authors.lastname: Artis
authors.affiliation: b Department of Physiology , Faculty of Medicine, Istanbul Medeniyet University , Istanbul , Turkey.
authors.forename: A Seda
authors.initials: AS
authors.lastname: Artis
authors.affiliation: c Department of General Surgery , Faculty of Medicine, Bozok University , Yozgat , Turkey.
authors.forename: Ergin
authors.initials: E
authors.lastname: Arslan
authors.affiliation: d Department of General Surgery , Faculty of Medicine, Adnan Menderes University , Aydın , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Mutlu
authors.affiliation: e Department of General Surgery , Agri State Hospital , Agri , Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Akay
authors.affiliation: f Department of Pathology , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Deniz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001672:Biocompatible Materials; D002432:Cecum / Q000293:injuries / Q000378:metabolism / Q000601:surgery; D013505:Digestive System Surgical Procedures / Q000009:adverse effects; D004195:Disease Models, Animal; D006820:Hyaluronic Acid; D007274:Injections, Intraperitoneal; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008567:Membranes, Artificial; D009569:Nitric Oxide / Q000378:metabolism; D011773:Pyruvates / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011773:Pyruvates; C118198:Seprafilm; C046522:ethyl pyruvate; D009569:Nitric Oxide; D008315:Malondialdehyde; D006820:Hyaluronic Acid
keywords: Ethyl pyruvate; Seprafilm; cecal abrasion; postoperative adhesion