title: The symptom trajectories to clinical remission in Chinese patients with unipolar major depressive disorder.
abstract: There is little understanding of how unipolar major depressive disorder (UMDD) symptoms evolve in response to antidepressant treatment. The present research examined the associations between symptom trajectories and clinical remission in Chinese patients with UMDD. A total of 165 outpatients with UMDD received treatment of fluoxetine (20 mg/day) for 6 weeks and were assessed for symptom severity at weeks 1, 2, 4, and 6. We found that patients with UMDD show heterogeneity in treatment response to fluoxetine. Psychomotor retardation is a prominent symptom during the 6 weeks of assessment, and its severity at baseline is negatively associated with clinical remission.
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Department of Psychiatry, Shenzhen Sixth Hospital, Shenzhen, China.
authors.forename: Jingjin
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Psychosomatics, Hunan Mental Hospital, Changsha, Hunan, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Chiang-Shan
authors.initials: CS
authors.lastname: Li
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. zhangyl69@vip.sina.com.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.|Beijing Huilongguan Hospital, Beijing, China.
authors.forename: Xingguang
authors.initials: X
authors.lastname: Luo
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012074:Remission Induction; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: clinical remission; symptom; trajectory; unipolar major depressive disorder