title: [Immune and genetic markers revealed in women working in technical rubber goods production].
abstract: Medical examination covered female workers engaged into chemical production of technical rubber goods, under combined exposure to chemicals (nitrogen oxides, carbon oxide) and noise exceeding MAC by 3.7-27.5%. Findings are increased phagocytary activity, lower level of serum IgM and IgG, suppressed expression of CD25 and CD95 T-cell receptors, and slower apoptosis induced via Fas receptor--all those indicators associated with work conditions. The disorders revealed are actualized on a basis of genetic variability features of the females, that is characterized by prevalence of mutant allels of FAS and TNFR genes with minor homozygous phenotype.
authors.forename: K G
authors.initials: KG
authors.lastname: Starkova
authors.forename: O V
authors.initials: OV
authors.lastname: Dolgikh
authors.forename: A V
authors.initials: AV
authors.lastname: Krivtsov
authors.forename: O A
authors.initials: OA
authors.lastname: Bubnova
authors.forename: V A
authors.initials: VA
authors.lastname: Horoshavin
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D000483:Alleles; D015703:Antigens, CD / Q000096:biosynthesis; D017209:Apoptosis / Q000187:drug effects / Q000276:immunology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D016022:Case-Control Studies; D002617:Chemical Industry; D005260:Female; D005838:Genotype; D006801:Humans; D055633:Immune System Phenomena / Q000187:drug effects* / Q000502:physiology; D007136:Immunoglobulins / Q000097:blood; D009154:Mutation; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*; D012408:Rubber; D012426:Russia; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D019014:fas Receptor / Q000235:genetics*
chemical_list: D000395:Air Pollutants, Occupational; D015703:Antigens, CD; D015415:Biomarkers; C491901:FAS protein, human; D007136:Immunoglobulins; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor; D012408:Rubber