title: Quantitative assessment of TIM-3 polymorphisms and cancer risk in Chinese Han population.
abstract: Previous studies have investigated the associations of TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) with cancer risk in Chinese Han population, but the results remain conflicting. Therefore, we conducted a meta-analysis to derive a more precise estimation of the associations. The pooled data showed that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were significantly associated with an increased risk of overall cancer in Chinese Han population. Subgroup analyses based on cancer system showed that TIM-3 -1516G/T polymorphism was only associated with an increased risk of digestive system cancer in Chinese Han population. TIM-3 -574G/T polymorphism was associated with an increased risk of digestive system cancer and other cancer in Chinese Han population. TIM-3 +4259T/G polymorphism was only associated with an increased risk of other cancer in Chinese Han population. In summary, our results indicated that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.
authors.affiliation: Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Xueren
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Youji
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu, China.|Jiangsu Key Laboratory of Molecule Imaging and Functional Imaging, Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Jianqiong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D000072597:Hepatitis A Virus Cellular Receptor 2 / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C448908:HAVCR2 protein, human; D000072597:Hepatitis A Virus Cellular Receptor 2
keywords: TIM-3; cancer; polymorphism