title: Supramolecular micelle-based nucleoapzymes for the catalytic oxidation of dopamine to aminochrome.
abstract: Lipidated DNAzymes or a lipidated Cu(II)-complex and lipidated aptamer sequences form supramolecular assemblies of micellar nucleoapzymes for the enhanced oxidation of dopamine to aminochrome. The catalytic functions of the micellar nucleoapzymes are attributed to the concentration of the substrate, using the aptamer units, in close proximity to the active sites.
authors.affiliation: Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il and Laboratory of Organic Chemistry, Wageningen University, Wageningen, The Netherlands.
authors.forename: H Bauke
authors.initials: HB
authors.lastname: Albada
authors.affiliation: Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: de Vries
authors.affiliation: Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.
authors.forename: Eyal
authors.initials: E
authors.lastname: Golub
authors.affiliation: Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.
authors.forename: Niels
authors.initials: N
authors.lastname: Klement
authors.affiliation: Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.
authors.forename: Andreas
authors.initials: A
authors.lastname: Herrmann
authors.affiliation: Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.
authors.forename: Itamar
authors.initials: I
authors.lastname: Willner
mesh_terms: D002384:Catalysis; D004298:Dopamine / Q000737:chemistry*; D045563:Indolequinones / Q000737:chemistry*; D008823:Micelles; D010084:Oxidation-Reduction
chemical_list: D045563:Indolequinones; D008823:Micelles; C091584:aminochrome 1; D004298:Dopamine