title: Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant.
abstract: A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.
authors.affiliation: Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, 980-8574, Japan. kosakatsume@gmail.com.
authors.forename: Ko
authors.identifier: http://orcid.org/0000-0003-2389-9314
authors.initials: K
authors.lastname: Sakatsume
authors.affiliation: Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, 980-8574, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akiyama
authors.affiliation: Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryocho, Aoba-ku, Sendai, 980-8575, Japan.
authors.forename: Kenki
authors.initials: K
authors.lastname: Saito
authors.affiliation: Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, 980-8574, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kawamoto
authors.affiliation: Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryocho, Aoba-ku, Sendai, 980-8575, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Horiuchi
authors.affiliation: Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, 980-8574, Japan. yoshisaiki@med.tohoku.ac.jp.
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Saiki
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000601:surgery*; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000209:etiology*; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D014842:von Willebrand Diseases / Q000097:blood / Q000209:etiology*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor
keywords: Acquired von Willebrand syndrome; Bleeding tendency; Ventricular assist device; Von Willebrand factors