title: Severe Acute Pancreatitis and Necrotizing Pancreatitis.
abstract: Acute pancreatitis results in nearly 250,000 admissions annually. Acute pancreatitis varies widely in its clinical presentation. Pancreatic necrosis accounts for substantial additional morbidity, with mortality rates remaining as high as 10% to 20% despite advances in critical care. The extent of necrosis correlates well with the incidence of infected necrosis, multiorgan failure, need for pancreatic debridement, and morbidity and mortality. Having established the diagnosis of pancreatic necrosis, goals of appropriately aggressive resuscitation should be established and adhered to in a multidisciplinary approach involving both medical and surgical critical care.
authors.affiliation: Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Suite 201, Atlanta, GA 30302, USA. Electronic address: rahul.maheshwari@emory.edu.
authors.forename: Rahul
authors.initials: R
authors.lastname: Maheshwari
authors.affiliation: Emory University School of Medicine, 1365 Clifton Road NE, B6100, Atlanta, GA 30322.
authors.forename: Ram M
authors.initials: RM
authors.lastname: Subramanian
mesh_terms: D003422:Critical Care / Q000379:methods*; D003646:Debridement; D006801:Humans; D009102:Multiple Organ Failure / Q000175:diagnosis* / Q000628:therapy*; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis* / Q000628:therapy*
keywords: Acute pancreatitis; Morbidity; Mortality; Necrotizing pancreatitis