title: Does the Microbiome Cause B27-related Acute Anterior Uveitis?
abstract: The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets. Received 31 October 2015; revised 7 January 2016; accepted 8 January 2016; published online 22 March 2016.
authors.affiliation: a Legacy Devers Eye Institute , Portland , Oregon , USA.|b Casey Eye Institute , Oregon Health & Science University , Portland , Oregon , USA.|c Department of Medicine , Oregon Health & Science University , Portland , Oregon , USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Rosenbaum
authors.affiliation: b Casey Eye Institute , Oregon Health & Science University , Portland , Oregon , USA.
authors.forename: Phoebe
authors.initials: P
authors.lastname: Lin
authors.affiliation: c Department of Medicine , Oregon Health & Science University , Portland , Oregon , USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Asquith
mesh_terms: D000208:Acute Disease; D000818:Animals; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D015796:HLA-B27 Antigen / Q000097:blood*; D006801:Humans; D014606:Uveitis, Anterior / Q000276:immunology / Q000382:microbiology*
chemical_list: D015796:HLA-B27 Antigen
keywords: Ankylosing spondylitis; HLA-B27; microbiome; spondyloarthropathy; uveitis