title: Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells.
abstract: Exercise decreases adiposity and improves metabolic health; however, the physiological and molecular underpinnings of these phenomena remain unknown. Here, we investigate the effect of endurance training on adipose progenitor lineage commitment. Using mice with genetically labeled adipose progenitors, we show that these cells react to exercise by decreasing their proliferation and differentiation potential. Analyses of mouse models that mimic the skeletal muscle adaptation to exercise indicate that muscle, in a non-autonomous manner, regulates adipose progenitor homeostasis, highlighting a role for muscle-derived secreted factors. These findings support a humoral link between skeletal muscle and adipose progenitors and indicate that manipulation of adipose stem cell function may help address obesity and diabetes.
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
authors.forename: Daniel
authors.initials: D
authors.lastname: Zeve
authors.affiliation: Department of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Millay
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
authors.forename: Jin
authors.initials: J
authors.lastname: Seo
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.|Department of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.|Department of Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Graff
mesh_terms: D041721:3T3-L1 Cells; D000222:Adaptation, Physiological; D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D019070:Cell Lineage; D049109:Cell Proliferation; D017077:Culture Media, Conditioned; D003920:Diabetes Mellitus / Q000378:metabolism; D005951:Glucose Tolerance Test; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006706:Homeostasis; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D018482:Muscle, Skeletal / Q000502:physiology*; D009765:Obesity / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D010805:Physical Conditioning, Animal; D010807:Physical Endurance / Q000502:physiology; D060888:Real-Time Polymerase Chain Reaction; D013234:Stem Cells / Q000166:cytology*; D019699:Thrombospondins / Q000378:metabolism
chemical_list: D017077:Culture Media, Conditioned; C517523:R-spondin3 protein, mouse; D019699:Thrombospondins; D049452:Green Fluorescent Proteins