title: A Practical Guide to The Cancer Genome Atlas (TCGA).
abstract: The Cancer Genome Atlas (TCGA) is one of the most ambitious and successful cancer genomics programs to date. The TCGA program has generated, analyzed, and made available genomic sequence, expression, methylation, and copy number variation data on over 11,000 individuals who represent over 30 different types of cancer. This chapter provides a brief overview of the TCGA program and detailed instructions and tips for investigators on how to find, access, and download this data.
authors.affiliation: Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD, USA. zhining.wang@nih.gov.
authors.forename: Zhining
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Research Administration Directorate, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, 8560 Progress Drive, Frederick, 21701, MD, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Jensen
authors.affiliation: Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD, USA.
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Zenklusen
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D023281:Genomics / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D012984:Software; D064878:Web Browser
keywords: Cancer genomics; Copy number; Methylation; Mutation; Next-generation sequencing; Proteomics; TCGA; The Cancer Genome Atlas; Transcriptome; miRNA