title: [CARBOHYDRATE METABOLISM IN TYPE 1 DIABETIC RATS UNDER THE CONDITIONS OF THE KIDNEY BEAN PODS AQUEOUS EXTRACT APPLICATION].
abstract: The influence of the aqueous pods extract of kidney bean (Phaseolus vulgaris) on indicators of carbohydrate metabolism under the condition of experimental type 1 diabetes in rats was studied. It was shown that long-term oral administration of the extract at a dose of 200 mg/kg to rats leads to the decreasing of blood glucose and glycosylated hemoglobin in the background of chronic hypoinsulinemia conditions. The use of studied extract led to an increase of glycogen synthase activity in rat muscle cells and hexokinase activity in rat liver cells under the conditions of type 1 diabetes. It was estimated that administration of the aqueous extract to control rats and animals with studied model of diabetes increases GLUT-4 protein content in muscle tissue. Thus, the mechanisms of P. vulgaris hypoglycemic action can be related with the ability of the particular phytoconstituents directly effect on key intracellular elements of insulin target tissues carbohydrate metabolism under the conditions of type 1 diabetes.
authors.forename: M Y
authors.initials: MY
authors.lastname: Kyznietsova
authors.forename: T I
authors.initials: TI
authors.lastname: Halenova
authors.forename: O M
authors.initials: OM
authors.lastname: Savchuk
authors.forename: V V
authors.initials: VV
authors.lastname: Vereschaka
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
mesh_terms: D000284:Administration, Oral; D000818:Animals; D021461:Animals, Outbred Strains; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006006:Glycogen Synthase / Q000235:genetics / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects / Q000201:enzymology; D006593:Hexokinase / Q000235:genetics / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000201:enzymology; D027805:Phaseolus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012639:Seeds / Q000737:chemistry; D013311:Streptozocin; D014866:Waste Products / Q000032:analysis; D014867:Water / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D006442:Glycated Hemoglobin; D006006:Glycogen Synthase; D006593:Hexokinase; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; D014866:Waste Products; D014867:Water; C495694:Slc2a4 protein, rat