title: Cross-Validation of Survival Bump Hunting by Recursive Peeling Methods.
abstract: We introduce a survival/risk bump hunting framework to build a bump hunting model with a possibly censored time-to-event type of response and to validate model estimates. First, we describe the use of adequate survival peeling criteria to build a survival/risk bump hunting model based on recursive peeling methods. Our method called "Patient Recursive Survival Peeling" is a rule-induction method that makes use of specific peeling criteria such as hazard ratio or log-rank statistics. Second, to validate our model estimates and improve survival prediction accuracy, we describe a resampling-based validation technique specifically designed for the joint task of decision rule making by recursive peeling (i.e. decision-box) and survival estimation. This alternative technique, called "combined" cross-validation is done by combining test samples over the cross-validation loops, a design allowing for bump hunting by recursive peeling in a survival setting. We provide empirical results showing the importance of cross-validation and replication.
authors.affiliation: Division of Bioinformatics, Center for Proteomics and Bioinformatics, Case Western Reserve University. Cleveland, OH 44106, USA.
authors.forename: Jean-Eudes
authors.initials: JE
authors.lastname: Dazard
authors.affiliation: Division of Bioinformatics, Center for Proteomics and Bioinformatics, Case Western Reserve University. Cleveland, OH 44106, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Choe
authors.affiliation: Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA 98195, USA; Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
authors.forename: Michael
authors.initials: M
authors.lastname: LeBlanc
authors.affiliation: Division of Biostatistics, Dept. of Epidemiology and Public Health, The University of Miami. Miami, FL 33136, USA.
authors.forename: J Sunil
authors.initials: JS
authors.lastname: Rao
keywords: Bump Hunting; K-Fold Cross-Validation; Non-Parametric Survival Analysis; Patient Rule-Induction Method; Survival/Risk Estimation; Survival/Risk Prediction