title: Long-term allergen exposure induces adipose tissue inflammation and circulatory system injury.
abstract: The purpose of this study was to study whether allergen exposure can induce inflammation and lower the anti-inflammation levels in serum and in adipose tissues, and further develop cardiovascular injury. Our data showed that heart rate was significantly higher in the OVA-challenged mice compared to control mice. Moreover, there were higher expressions of pro-inflammation genes in the OVA-challenged mice in adipose tissues, and the expressions of anti-inflammation genes were lower. The levels of inflammation mediators were associated in serum and adipose tissues. The level of circulatory injury lactate dehydrogenase was significantly associated with the levels of E-selectin, resistin and adiponectin in the serum. The hematoxylin and eosin and immunohistochemistry stains indicated the OVA-challenged mice had higher levels of inflammation. In summary, the current study demonstrated allergen exposure can cause cardiovascular injury, and inflammatory mediators in adipose tissues play an important role in the pathogenesis of cardiovascular injury.
authors.affiliation: Department of Environmental and Occupational Health, Out-Patient Building, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70403, Taiwan.
authors.forename: Chien-Cheng
authors.initials: CC
authors.lastname: Jung
authors.affiliation: Department of Environmental and Occupational Health, Out-Patient Building, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70403, Taiwan. Electronic address: hjsu@mail.ncku.edu.tw.
authors.forename: Huey-Jen
authors.initials: HJ
authors.lastname: Su
mesh_terms: D052242:Adiponectin / Q000097:blood; D000485:Allergens / Q000276:immunology; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000276:immunology*; D019040:E-Selectin / Q000097:blood; D006339:Heart Rate; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000276:immunology*; D007249:Inflammation / Q000209:etiology / Q000276:immunology*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D052243:Resistin / Q000097:blood; D013997:Time Factors
chemical_list: D052242:Adiponectin; D000485:Allergens; D019040:E-Selectin; D052243:Resistin; D007770:L-Lactate Dehydrogenase
keywords: Adipose tissue; Allergen; Cardiovascular injury