title: Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide.
abstract: Using the whole-cell patch-clamp method, the ability of arginine-containing tripeptide Ac-RER-NH2, dipeptide Ac-RR-NH2, and free Arg molecule to modulate the membrane excitability of nociceptors was studied. Extracellular Ac-RER-NH2 upon interaction with the outer membrane of the nociceptive neuron decreases the Zeff value of the activation gating system of Nav1.8 channels. Thus, the tripeptide Ac-RER-NH2 can be considered as a new effective and safe analgesic.
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia. shelt76@mail.ru.
authors.forename: T N
authors.initials: TN
authors.lastname: Shelykh
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Rogachevsky
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia.
authors.forename: A D
authors.initials: AD
authors.lastname: Nozdrachev
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Veselkina
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Podzorova
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia.
authors.forename: B V
authors.initials: BV
authors.lastname: Krylov
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia.
authors.forename: V B
authors.initials: VB
authors.lastname: Plakhova
mesh_terms: D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D005727:Ganglia, Spinal / Q000166:cytology; D009475:Neurons, Afferent / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D059225:Nociception; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D061566:Voltage-Gated Sodium Channels / Q000378:metabolism
chemical_list: D009842:Oligopeptides; D061566:Voltage-Gated Sodium Channels