title: Genomic and proteomic profiles of Acholeplasma laidlawii strains differing in sensitivity to ciprofloxacin.
abstract: As a result of comparative analysis of complete genomes as well as cell and vesicular proteomes of A. laidlawii strains differing in sensitivity to ciprofloxacin, it was first shown that the mycoplasma resistance to the antibiotic is associated with the reorganization of genomic and proteomic profiles, which concerns many genes and proteins involved in fundamental cellular processes and realization of bacterial virulence.
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, Kazan Tatarstan, 420111, Russia. elena-med@list.ru.|Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan Tatarstan, 420008, Russia. elena-med@list.ru.
authors.forename: E S
authors.initials: ES
authors.lastname: Medvedeva
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, Kazan Tatarstan, 420111, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Davydova
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, Kazan Tatarstan, 420111, Russia.|Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan Tatarstan, 420008, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Mouzykantov
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, Kazan Tatarstan, 420111, Russia.|Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan Tatarstan, 420008, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Baranova
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, Kazan Tatarstan, 420111, Russia.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Grigoreva
authors.affiliation: Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan Tatarstan, 420008, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Siniagina
authors.affiliation: Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan Tatarstan, 420008, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Boulygina
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, Kazan Tatarstan, 420111, Russia.|Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan Tatarstan, 420008, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Chernova
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, Kazan Tatarstan, 420111, Russia.|Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan Tatarstan, 420008, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Chernov
mesh_terms: D000127:Acholeplasma / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D020543:Proteome
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D020543:Proteome; D002939:Ciprofloxacin