title: Pediatric Nasopharyngeal Cancer: Case Report and Review of the Literature.
abstract: Pediatric nasopharyngeal carcinoma, also referred to as cavum carcinoma, is a rare pediatric disease with an infrequent incidence rate. We present the case of a pediatric patient with nasopharyngeal cancer who received an adult schedule of concomitant chemotherapy and conformal radiotherapy with a brachytherapy boost. Adult protocols with high radiotherapy doses are not commonly used in pediatric patients due to the high comorbidity associated with this practice. In this case, the patient displayed excellent overall survival, a longer disease-free period, and fewer side effects and comorbidities, even in the absence of interferon therapy, which is not easily available in low-income countries. In addition, this case shows that conformal radiotherapy and brachytherapy are options that can be used to escalate the radiotherapy dose and decrease side effects. A 12-year-old female pediatric patient presented to our outpatient clinic with an eight-month history of moderate-to-severe otalgia, intermittent hyaline rhinorrhea, asthenia, adynamia, nasal congestion, epistaxis in the previous months, and local pruritus. Upon physical examination, a 60x60 mm mass was detected at level II of the neck, and a biopsy of the lesion confirmed a histopathological diagnosis of undifferentiated carcinoma compatible with nasopharyngeal carcinoma. The patient was considered to have clinical Stage III cancer, and she received an adult Al-Sarraf protocol with chemoradiotherapy and an intracavitary brachytherapy boost. The patient had a complete response, and she remains without local or distance relapse. Treating pediatric nasopharyngeal carcinoma patients with the Al-Sarraf protocol could be a feasible modality, as observed in this clinical case, despite the elevated cost of using interferon-beta in low-income countries when using more advanced radiotherapy techniques such as conformal radiotherapy and now, modulated intensity radiotherapy. It should be noted that brachytherapy boosts should be used with caution in pediatric patients; the potential side effects should be weighed against improved local control.
authors.affiliation: Department of Radiation Oncology, Instituto Nacional de Cancerologia, Universidad Militar Nueva Granada, Bogota, D.C., Colombia.
authors.forename: Alejandro
authors.initials: A
authors.lastname: González-Motta
authors.affiliation: Department of Radiation Oncology, Instituto Nacional de Cancerologia, Universidad Militar Nueva Granada, Bogota, D.C., Colombia.
authors.forename: Garvin
authors.initials: G
authors.lastname: González
authors.affiliation: Department of Radiation Oncology, Instituto Nacional de Cancerologia, Universidad Militar Nueva Granada, Bogota, D.C., Colombia.
authors.forename: Yurany
authors.initials: Y
authors.lastname: Bermudéz
authors.affiliation: Department of Radiation Oncology, Instituto Nacional de Cancerologia, Universidad Militar Nueva Granada, Bogota, D.C., Colombia.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Maldonado
authors.affiliation: Clinical Research Group, Instituto Nacional de Cancerologia, Bogota, D.C., Colombia.
authors.forename: Javier M
authors.initials: JM
authors.lastname: Castañeda
authors.affiliation: Clinical Research Group, Instituto Nacional de Cancerologia, Bogota, D.C., Colombia.
authors.forename: David
authors.initials: D
authors.lastname: Lopéz
authors.affiliation: Department of Radiation Oncology, Instituto Nacional de Cancerologia, Universidad Militar Nueva Granada, Bogota, D.C., Colombia.
authors.forename: Martha
authors.initials: M
authors.lastname: Cotes-Mestre
keywords: brachytherapy boost; chemoradiotherapy; nasopharyngeal cancer; pediatric nasopharyngeal carcinoma