title: Basic Physicochemical Properties of Polyethylene Glycol Coated Gold Nanoparticles that Determine Their Interaction with Cells.
abstract: A homologous nanoparticle library was synthesized in which gold nanoparticles were coated with polyethylene glycol, whereby the diameter of the gold cores, as well as the thickness of the shell of polyethylene glycol, was varied. Basic physicochemical parameters of this two-dimensional nanoparticle library, such as size, ζ-potential, hydrophilicity, elasticity, and catalytic activity ,were determined. Cell uptake of selected nanoparticles with equal size yet varying thickness of the polymer shell and their effect on basic structural and functional cell parameters was determined. Data indicates that thinner, more hydrophilic coatings, combined with the partial functionalization with quaternary ammonium cations, result in a more efficient uptake, which relates to significant effects on structural and functional cell parameters.
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany. pdelpino@cicbiomagune.es.|CIC biomaGUNE, San Sebastian, Spain. pdelpino@cicbiomagune.es.
authors.forename: Pablo
authors.identifier: 0000-0003-1318-6839
authors.initials: P
authors.lastname: Del Pino
authors.affiliation: Fachbereich Chemie, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pelaz
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Kantner
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Raimo
authors.initials: R
authors.lastname: Hartmann
authors.affiliation: CIC biomaGUNE, San Sebastian, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Martinez de Baroja
authors.affiliation: CIC biomaGUNE, San Sebastian, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Gallego
authors.affiliation: CIC biomaGUNE, San Sebastian, Spain.
authors.forename: Marco
authors.initials: M
authors.lastname: Möller
authors.affiliation: Radiology Department, KULeuven Campus Gasthuisberg, Leuven, Belgium.
authors.forename: Bella B
authors.initials: BB
authors.lastname: Manshian
authors.affiliation: Radiology Department, KULeuven Campus Gasthuisberg, Leuven, Belgium.
authors.forename: Stefaan J
authors.initials: SJ
authors.lastname: Soenen
authors.affiliation: Fachbereich Chemie, Philipps Universität Marburg, Marburg, Germany.
authors.forename: René
authors.initials: R
authors.lastname: Riedel
authors.affiliation: Fachbereich Chemie, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Hampp
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany. wolfgang.parak@physik.uni-marburg.de.|CIC biomaGUNE, San Sebastian, Spain. wolfgang.parak@physik.uni-marburg.de.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
mesh_terms: D000818:Animals; D002460:Cell Line; D002627:Chemistry, Physical; D006046:Gold / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011092:Polyethylene Glycols; D006046:Gold
keywords: gold nanoparticles; nanoparticle uptake; physicochemical properties; polyethylene glycol; toxicity