title: Nitrogen and Phosphorus Co-Doped Carbon Nanodots as a Novel Fluorescent Probe for Highly Sensitive Detection of Fe(3+) in Human Serum and Living Cells.
abstract: Chemical doping with heteroatoms can effectively modulate physicochemical and photochemical properties of carbon dots (CDs). However, the development of multi heteroatoms codoped carbon nanodots is still in its early stage. In this work, a facile hydrothermal synthesis strategy was applied to synthesize multi heteroatoms (nitrogen and phosphorus) codoped carbon nanodots (N,P-CDs) using glucose as carbon source, and ammonia, phosphoric acid as dopant, respectively. Compared with CDs, the multi heteroatoms doped CDs resulted in dramatic improvement in the electronic characteristics and surface chemical activities. Therefore, the N,P-CDs prepared as described above exhibited a strong blue emission and a sensitive response to Fe(3+). The N,P-CDs based fluorescent sensor was then applied to sensitively determine Fe(3+) with a detection limit of 1.8 nM. Notably, the prepared N,P-CDs possessed negligible cytotoxicity, excellent biocompatibility, and high photostability. It was also applied for label-free detection of Fe(3+) in complex biological samples and the fluorescence imaging of intracellular Fe(3+), which indicated its potential applications in clinical diagnosis and other biologically related study.
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University , 15 Yucai Road, Guilin 541004, China.|Key Laboratory of Regional Ecological Environment Analysis and Pollution Control of West Guangxi, College of Chemistry and Environmental Engineering, Baise University , 21 Zhongshan Road, Baise 533000, China.
authors.forename: Bingfang
authors.initials: B
authors.lastname: Shi
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University , 15 Yucai Road, Guilin 541004, China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Su
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University , 15 Yucai Road, Guilin 541004, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University , 15 Yucai Road, Guilin 541004, China.
authors.forename: Mengjiao
authors.initials: M
authors.lastname: Huang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University , 15 Yucai Road, Guilin 541004, China.
authors.forename: Rongjun
authors.initials: R
authors.lastname: Liu
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University , 15 Yucai Road, Guilin 541004, China.
authors.forename: Shulin
authors.initials: S
authors.lastname: Zhao
mesh_terms: D002244:Carbon; D002470:Cell Survival; D005456:Fluorescent Dyes; D006801:Humans; D049329:Nanostructures; D009584:Nitrogen; D010758:Phosphorus; D045663:Quantum Dots
chemical_list: D005456:Fluorescent Dyes; D010758:Phosphorus; D002244:Carbon; D009584:Nitrogen
keywords: Fe3+ detection; cell imaging; doped carbon nanodots; nitrogen; phosphorus