title: Approaching Perfection: New Developments in Zebrafish Genome Engineering.
abstract: Programmable nucleases have revolutionized zebrafish genetics by enabling targeted genome modifications. In this issue of Developmental Cell, Hoshijima et al. (2016) take genome modification in the zebrafish to the next level, demonstrating the efficient use of homologous recombination to make genetic tools for a range of applications.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, B2-152, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA.
authors.forename: Arish N
authors.initials: AN
authors.lastname: Shah
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, B2-152, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA. Electronic address: cmoens@fhcrc.org.
authors.forename: Cecilia B
authors.initials: CB
authors.lastname: Moens
mesh_terms: D000818:Animals; D005818:Genetic Engineering / Q000379:methods*; D015027:Zebrafish / Q000235:genetics*