title: In Vivo Assessment of Choroid in Diabetic Retinopathy by Enhanced Depth Imaging in Spectral Domain Optical Coherence Tomography.
abstract: OBJECTIVE
  The aim of this study was to measure the largest hyporeflective (LHR) lumen in the choroid and subfoveal choroidal thickness (SFCT) in patients with diabetic retinopathy (DR) and in control subjects using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  This was a prospective, cross-sectional study.
  
  
  METHODS
  This was a study of 240 eyes of DR patients (n = 120) and control subjects (n = 120) matched for age, sex, and refractive error. The LHR lumens of the choroidal vessels and SFCT were measured by EDI SD-OCT. Further intergroup classification into nonproliferative and proliferative DR, with or without macular edema, was done.
  
  
  RESULTS
  The mean diameter of the LHR lumen in DR patients (139.24 ± 35.53 μm) was significantly smaller (P < 0.01) than in control subjects (186.37 ± 26.43 μm). The mean SFCT was also significantly less (P < 0.01) in patients with diabetes (277.15 ± 32.24 μm) as compared with control subjects (313.68 ± 25.13 μm). There was no significant intergroup variation.
  
  
  CONCLUSIONS
  Patients with DR showed smaller LHR lumen and SFCT as compared with control eyes. In vivo assessment of the choroid in DR is possible using EDI SD-OCT.
authors.affiliation: From the Retina Foundation, Amedabad, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Verma
authors.forename: Manish
authors.initials: M
authors.lastname: Nagpal
authors.forename: Navneet
authors.initials: N
authors.lastname: Mehrotra
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002829:Choroid / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*