title: Diffuse HIV-associated seborrheic dermatitis - a case series.
abstract: Seborrheic dermatitis (SD) is reported to have distinct clinical and histologic presentations in patients with HIV infection. Here we present 20 cases to further define some of these unique characteristics. Common features include erythematous, scaly papules, and plaques involving areas beyond the typical seborrheic distribution; thick, greasy scale on the scalp; and an increased frequency of erythroderma. Histologically, there is widespread parakeratosis, spongiosis, and necrotic keratinocytes. Treatment is often difficult, requiring prolonged use of oral and topical antifungals and corticosteroids as well as antibiotics for bacterial superinfection. SD with these features represents a marker for HIV infection and can aid in early diagnosis.
authors.affiliation: University of Pennsylvania, PA, USA Amy.forrestel@uphs.upenn.edu.
authors.forename: Amy K
authors.initials: AK
authors.lastname: Forrestel
authors.affiliation: University of Pennsylvania, PA, USA.
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Kovarik
authors.affiliation: University of Kwazulu-Natal, South Africa.
authors.forename: Anisa
authors.initials: A
authors.lastname: Mosam
authors.affiliation: University of Washington, Seattle, USA.
authors.forename: Deepti
authors.initials: D
authors.lastname: Gupta
authors.affiliation: University of California San Francisco, USA.
authors.forename: Toby A
authors.initials: TA
authors.lastname: Maurer
authors.affiliation: University of Pennsylvania, PA, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Micheletti
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D012628:Dermatitis, Seborrheic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents
keywords: AIDS; HIV; Seborrheic dermatitis; dermatology; human immunodeficiency virus