title: Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG, and NRIP1 genes to migraine susceptibility in Turkish population.
abstract: Migraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease. Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study was to evaluate genetic variants in genes involved in oestrogen receptor and oestrogen hormone metabolism in a Turkish population. A total of 12 SNPs in the ESR1, ESR2, FSHR, CYP19A1, SHBG and NRIP1 genes were genotyped in 142 migraine cases and 141 nonmigraine controls, using a BioMark 96.96 dynamic array system. In addition, gene-gene interactions were analysed using generalized multifactor dimensionality reduction (GMDR) methods. According to GMDR analysis, our results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1, FSHR, ESR1 and NRIP1. Single-gene variant analysis showed that a significant association was observed between the TT genotype of rs10046 and migraine susceptibility.When the analysis was performed only in women, the GG genotype of rs2229741 was different between migraineurs and controls.When the female migraine patients were divided into two groups, migraine related to menstruation (MRM) or migraine not related to menstruation (MNRM), GG genotype of rs726281 was significantly associated with MRM. These results suggested that rs10046 could play a potential role in migraine susceptibility in Turkish population. Also, the rare GG genotype of rs726281 appears to influence migraine susceptibility in a recessive manner in MRM subgroup of female patients. In addition, variant GG genotype of rs2229741 may reduce the risk of migraine in Turkish women.
authors.affiliation: Department of Medical Genetics Diyarbakir 21280, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: CoŞkun
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yůcel
authors.forename: Abdullah
authors.initials: A
authors.lastname: Çim
authors.forename: Beyhan
authors.initials: B
authors.lastname: Cengiz
authors.forename: Serdar
authors.initials: S
authors.lastname: Oztuzcu
authors.forename: Sefer
authors.initials: S
authors.lastname: Varol
authors.forename: Hasan H
authors.initials: HH
authors.lastname: Özdemir
authors.forename: ErtuĞrul
authors.initials: E
authors.lastname: Uzar
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D001141:Aromatase / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D000078723:Nuclear Receptor Interacting Protein 1; D020641:Polymorphism, Single Nucleotide; D011962:Receptors, FSH / Q000235:genetics*; D012738:Sex Hormone-Binding Globulin / Q000235:genetics*; D014421:Turkey
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C506487:ESR1 protein, human; C000600034:ESR2 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D011962:Receptors, FSH; D012738:Sex Hormone-Binding Globulin; D001141:Aromatase; C561410:CYP19A1 protein, human