title: Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazines.
abstract: Parallel solid phase synthesis offers a unique opportunity for the synthesis and screening of large numbers of compounds and significantly enhances the prospect of finding new leads. We report the synthesis and antitubercular activity of chiral 1,2,4-trisubstituted piperazines derived from resin bound acylated dipeptides against Mycobacterium tuberculosis strain H37Rv.
authors.affiliation: University of Central Florida, College of Medicine, Burnett School of Biomedical Sciences, 6900 Lake Nona Blvd, Orlando, FL 32827, United States.
authors.forename: Kyle H
authors.initials: KH
authors.lastname: Rohde
authors.affiliation: Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, United States.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Michaels
authors.affiliation: Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, United States. Electronic address: adeln@tpims.org.
authors.forename: Adel
authors.initials: A
authors.lastname: Nefzi
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D010879:Piperazines
keywords: Antitubercular; Combinatorial chemistry; Solid phase synthesis; Substituted piperazines