title: Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis.
abstract: Within the first week of the disease, acute kidney injury (AKI) is among the most common causes of mortality in acute pancreatitis (AP). Recently, serum angiopoietin-2 (Ang-2) has been associated with hyperdynamic state of the systemic circulation. The aim of this study was to examine the associations between Ang-2 and the clinical AP severity during the first 72 hours of the disease, and organ disfunction, including AKI. Methods. Study included patients admitted to the surgery ward, diagnosed with AP. AKI was diagnosed according to KDIGO guidelines and renal failure according to modified Marshall scoring system. Ang-2 was determined in serum with ELISA. Results. AP was classified as mild (MAP) in 71% of patients, moderately severe (MSAP) in 22%, and severe (SAP) in 8%. During the first 72 hours of AP, 11 patients developed AKI and 6 developed renal failure. Ang-2 at 24, 48, and 72 hours following the onset of AP symptoms significantly predicted SAP and MSAP, as well as AKI and renal failure. Also, Ang-2 significantly correlated with acute phase proteins as well as with the indicators of renal disfunction. Conclusions. Serum Ang-2 may be a relevant predictor of AP severity, in particular of the development of AP-renal syndrome.
authors.affiliation: Surgery Department, The District Hospital, 22 Szpitalna Street, 34-200 Sucha Beskidzka, Poland; Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, 12 Kopernika Street, 31-034 Krakow, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Sporek
authors.affiliation: Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Dumnicka
authors.affiliation: St'Queen Jadwiga Clinical District Hospital No. 2, 60 Lwowska Street, 35-301 Rzeszow, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gala-Bladzinska
authors.affiliation: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ceranowicz
authors.affiliation: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland.
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Warzecha
authors.affiliation: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Dembinski
authors.affiliation: Institute of Physics, Department of Medical Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, 11 Lojasiewicza Street, 30-348 Krakow, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Stepien
authors.affiliation: Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, 12 Kopernika Street, 31-034 Krakow, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Walocha
authors.affiliation: Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Drozdz
authors.affiliation: Department of Nephrology, Faculty of Medicine, Jagiellonian University Medical College, 15c Kopernika Street, 31-501 Krakow, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Kuzniewski
authors.affiliation: Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 15a Kopernika Street, 31-501 Krakow, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Kusnierz-Cabala
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000097:blood* / Q000175:diagnosis*; D000368:Aged; D042702:Angiopoietin-2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D042702:Angiopoietin-2