title: Reversible cerebral vasoconstriction syndrome associated with interferon beta-1a use for multiple sclerosis.
abstract: Reversible cerebral vasoconstriction syndrome (RCVS) has been associated with multiple medications, cocaine, pregnancy, migraine, and other conditions.
  
  
  
  RCVS associated with interferon beta use has never before been described.
  
  
  
  We describe the case of a 20-year-old female who developed acute onset severe headache and was found to have subarachnoid hemorrhage 2 months after initiating Rebif (Interferon beta-1a) for multiple sclerosis (MS). Cerebral angiography showed multiple areas of distal stenosis and dilatation with radiographic resolution 1 month later.
  
  
  
  This is the first case report of RCVS in an MS patient treated with Rebif.
authors.affiliation: Department of Neurology, Cleveland Clinic, Cleveland, OH, USA tamara.strohm@gmail.com strohmt@ccf.org.
authors.forename: Tamara
authors.initials: T
authors.lastname: Strohm
authors.affiliation: Department of Neurology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Burhan
authors.initials: B
authors.lastname: Chaudhry
authors.affiliation: Department of Neurology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Willis
authors.affiliation: Department of Neurology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Shook
mesh_terms: D000328:Adult; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D000068556:Interferon beta-1a / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000188:drug therapy*; D013577:Syndrome; D014661:Vasoconstriction; D055815:Young Adult
chemical_list: D007155:Immunologic Factors; D000068556:Interferon beta-1a
keywords: Beta-interferon; Rebif; multiple sclerosis; reversible cerebral vasoconstriction syndrome