title: Systemic sclerosis: Sexual dysfunction and lower urinary tract symptoms in 73 patients.
abstract: OBJECTIVE
  To estimate the frequency of lower urinary tract symptoms (LUTS) and sexual dysfunction in patients with systemic sclerosis (SSc) and associate these symptoms with clinical and functional parameters including disability and quality of life.
  
  
  METHODS
  Patients with SSc seen in Cochin hospital, Paris, between February and April 2010 were assessed for disease type, LUTS by the Urinary Symptom Profile scale, sexual dysfunction by the Feminine Sexual Function Index (FSFI) and International Index for the Erectile Function (IIEF-5), global disability by the Health Assessment Questionnaire and McMaster Toronto Arthritis Patient Preference Disability Questionnaire, anxiety and depression by the Hospital Anxiety and Depression scale, and quality of life by the Medical Outcomes Survey Short Form 36.
  
  
  RESULTS
  The most frequent LUTS among the 73 patients included (13 males) were overactive bladder (n=11, 84.6%) and dysuria (n=8, 61.5%) for males and overactive bladder (n=51, 85%) and incontinence (n=29, 48.3%) for females. Among women, 32 (53.2%) were sexually active: 20 (62.5%) had sexual disorders (mean [SD] FSFI score 16.3 [6.2]), the most compromised domains being desire (mean score 2.6 [1.3]) and arousal (mean score 2.5 [1.4]). Sexual disorders were associated with short disease duration (P=0.01) and high depression (P=0.04) scores. For men, 7/8 (87.5%) had erectile dysfunction (mean IIEF-5 score 16 [5.3]).
  
  
  CONCLUSIONS
  LUTS seem to be more frequent in SSc patients than in the general population. The most frequent symptom was overactive bladder.
authors.affiliation: AP-HP, Cochin Hospital, Université Paris Descartes, Department of Rehabilitation, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm U1153 épidémiologie clinique des maladies ostéo-articulaires, Inserm Institut Fédératif de Recherche sur le Handicap (IFR 25), 75651 Paris, France. Electronic address: sanchez.katherine@gmail.com.
authors.forename: Katherine
authors.initials: K
authors.lastname: Sanchez
authors.affiliation: AP-HP, Raymond-Poincaré Hospital, Department of Rehabilitation, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Denys
authors.affiliation: AP-HP, Raymond-Poincaré Hospital, Department of Rehabilitation, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
authors.forename: François
authors.initials: F
authors.lastname: Giuliano
authors.affiliation: AP-HP, Cochin Hospital, Université Paris Descartes, Department of Rehabilitation, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm U1153 épidémiologie clinique des maladies ostéo-articulaires, Inserm Institut Fédératif de Recherche sur le Handicap (IFR 25), 75651 Paris, France.
authors.forename: Clémence
authors.initials: C
authors.lastname: Palazzo
authors.affiliation: AP-HP, Cochin Hospital, Reference Center for necrotizing vasculitides and systemic sclerosis, Université Paris Descartes, Faculty of Medicine, Department of Internal Medicine, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Bérezné
authors.affiliation: AP-HP, Cochin Hospital, Université Paris Descartes, Department of Rehabilitation, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm U1153 épidémiologie clinique des maladies ostéo-articulaires, Inserm Institut Fédératif de Recherche sur le Handicap (IFR 25), 75651 Paris, France.
authors.forename: Hanane
authors.initials: H
authors.lastname: Abid
authors.affiliation: AP-HP, Cochin Hospital, Université Paris Descartes, Department of Rehabilitation, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm U1153 épidémiologie clinique des maladies ostéo-articulaires, Inserm Institut Fédératif de Recherche sur le Handicap (IFR 25), 75651 Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Rannou
authors.affiliation: AP-HP, Cochin Hospital, Université Paris Descartes, Department of Rehabilitation, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm U1153 épidémiologie clinique des maladies ostéo-articulaires, Inserm Institut Fédératif de Recherche sur le Handicap (IFR 25), 75651 Paris, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Poiraudeau
authors.affiliation: AP-HP, Cochin Hospital, Reference Center for necrotizing vasculitides and systemic sclerosis, Université Paris Descartes, Faculty of Medicine, Department of Internal Medicine, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Mouthon
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications*; D012735:Sexual Dysfunction, Physiological / Q000209:etiology*