title: Fabrication of Mesoporous Silica Nanoparticle with Well-Defined Multicompartment Structure as Efficient Drug Carrier for Cancer Therapy in Vitro and in Vivo.
abstract: Vaterite particles are composed of particulate CaCO3 nanoparticles, which offer an ideal platform to synthesize architectures with hierarchical structure. Herein we show that mesoporous silica particles with well-defined multicompartment structure are fabricated by employing vaterite particles as templates. The obtained silica particles inherited the structure feature of vaterite and had excellent biocompatibility and biodegradability. Moreover, the silica particles were established as an efficient anticancer drugs carrier compared with hollow silica particles, which could be applied in cancer therapy in vitro and in vivo. The silica particles obtained here offer a cheap, facile, environmentally friendly avenue to assembly of hierarchical drugs carriers.
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Anhe
authors.initials: A
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: School of Public Health, Jilin University , Changchun 130021, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Qi
authors.affiliation: School of Public Health, Jilin University , Changchun 130021, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Qi
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Fei
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190, China.
authors.forename: Hongchao
authors.initials: H
authors.lastname: Ma
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.|Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190, China.
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016062:Porosity; D012822:Silicon Dioxide / Q000008:administration & dosage* / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide
keywords: cancer therapy; drug carrier; multicompartment structure; silica particles; vaterite particles