title: Urological Complications and BK Virus-Associated Diseases Under Allogenic Stem Cell Transplantation.
abstract: Every year 50,000 patients receive a stem cell transplantation worldwide, but there is lack of data pertaining to urological complications.
  
  
  METHODS
  We performed a retrospective analysis of all adult patients undergoing their first allogenic stem cell transplantation from January 2011 to June 2013 in our institution. Statistical tests performed were Pearson's correlation, chi-square testing and logistic regression using SPSS 22.0.
  
  
  RESULTS
  We identified 39 patients (22 males, 17 females). Twenty four patients (61.5%) had a urological complication. Most frequent urologic complications were bacterial urinary tract infection (n = 13; 33.3%), acute renal failure (n = 6; 15.4%) and BK virus-associated haemorrhagic cystitis (n = 5; 12.8%). BK viruria was detected in 12 patients (30.8%). We observed an association of creatinine increase (about 20 µmol/l at time of onset of BK viruria) with BK viruria (Pearson's correlation 0.64; p = 0.01), and BK viruria is significantly linked to acute renal failure (Pearson's correlation 0.35; p = 0.029). In univariate regression, BK viruria is significantly linked to urological complication (p = 0.025).
  
  
  CONCLUSIONS
  We suggest that BK virus infection during stem cell transplantation can lead to BK virus associated nephropathy, which is so far only known from patients after kidney transplantation.
authors.affiliation: Department of Urology, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Laila
authors.initials: L
authors.lastname: Schneidewind
authors.forename: Thomas
authors.initials: T
authors.lastname: Neumann
authors.forename: Martin
authors.initials: M
authors.lastname: Burchardt
authors.forename: William
authors.initials: W
authors.lastname: Krüger
mesh_terms: D001739:BK Virus; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D027601:Polyomavirus Infections; D012189:Retrospective Studies; D014412:Tumor Virus Infections