title: Cost and mortality data of a regional limb salvage and hyperbaric medicine program for Wagner Grade 3 or 4 diabetic foot ulcers.
abstract: We obtained costs and mortality data in two retrospective cohorts totaling 159 patients who have diabetes mellitus and onset of a diabetic foot ulcer (DFU). Data were collected from 2005 to 2013, with a follow-up period through September 30, 2014. A total of 106 patients entered an evidence-based limb salvage protocol (LSP) for Wagner Grade 3 or 4 (WG3/4) DFU and intention-to-treat adjunctive hyperbaric oxygen (HBO₂) therapy. A second cohort of 53 patients had a primary lower extremity amputation (LEA), either below the knee (BKA) or above the knee (AKA) and were not part of the LSP. Ninety-six of 106 patients completed the LSP/HBO₂with an average cost of USD $33,100. Eighty-eight of 96 patients (91.7%) who completed the LSP/HBO₂had intact lower extremities at one year. Thirty-four of the 96 patients (35.4%) died during the follow-up period. Costs for a historical cohort of 53 patients having a primary major LEA range from USD $66,300 to USD $73,000. Twenty-five of the 53 patients (47.2%) died. The difference in cost of care and mortality between an LSP with adjunctive HBO₂therapy vs. primary LEA is staggering. We conclude that an aggressive limb salvage program that includes HBO₂ therapy is cost-effective.
authors.forename: J V
authors.initials: JV
authors.lastname: Eggert
authors.forename: E R
authors.initials: ER
authors.lastname: Worth
authors.forename: C C
authors.initials: CC
authors.lastname: Van Gils
mesh_terms: D000671:Amputation, Surgical / Q000191:economics* / Q000401:mortality* / Q000706:statistics & numerical data; D003362:Cost-Benefit Analysis; D017719:Diabetic Foot / Q000145:classification / Q000191:economics / Q000401:mortality / Q000628:therapy; D017721:Hospital Costs; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000191:economics* / Q000401:mortality*; D057194:Intention to Treat Analysis; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage / Q000191:economics* / Q000401:mortality*; D035002:Lower Extremity / Q000601:surgery; D015397:Program Evaluation; D012189:Retrospective Studies; D015996:Survival Rate; D017211:Treatment Failure; D014589:Utah