title: [Atipical uremic hemolityc syndrome in pregnancy].
abstract: Atypical haemolytic uraemic syndrome is one of the main variants of thrombotic microangiopathy, and is characterized by excessive complement activation in the microvasculature. It is also characterised by the clinical triad; non-immune haemolytic anaemia, thrombocytopenia, and acute renal failure. In addition, 60% of patients have mutations in the genes encoding complement regulators (factor H, factor I, membrane cofactor proteins, and thrombomodulin), activators (factor B and C3), as well as autoantibodies against factor H. Multiple factors are required for the disease to manifest itself, including a trigger and gene mutations with adequate penetration. Being one of the differential diagnoses of preeclampsia- eclampsia and HELLP syndrome means that the clinician must be familiar with the disease due to its high mortality, which can be modified with early diagnosis and comprehensive treatment.
authors.affiliation: Medicina Crítica en Obstetricia, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México. Electronic address: gmemiinv@gmail.com.
authors.forename: Ángel Augusto
authors.initials: ÁA
authors.lastname: Pérez-Calatayud
authors.affiliation: Medicina Crítica en Obstetricia, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.
authors.forename: Jesús Carlos
authors.initials: JC
authors.lastname: Briones-Garduño
authors.affiliation: Medicina Crítica en Obstetricia, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.
authors.forename: Mercedes Del Pilar
authors.initials: Mdel P
authors.lastname: Álvarez-Goris
authors.affiliation: Medicina Crítica en Obstetricia, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sánchez Zamora
authors.affiliation: Medicina Crítica en Obstetricia, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.
authors.forename: Angélica A
authors.initials: AA
authors.lastname: Torres Aguilar
authors.affiliation: Instituto Ingenes, Ciudad de México, México.
authors.forename: Rosa Elba
authors.initials: RE
authors.lastname: Mendoza-Mórales
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D065766:Atypical Hemolytic Uremic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D003167:Complement Activation / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D010956:Plasmapheresis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D011256:Pregnancy Outcome; D011379:Prognosis
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C481642:eculizumab
keywords: Atypical haemolytic uraemic syndrome; Embarazo; Microangiopatía trombótica; Pregnancy; Síndrome urémico hemolítico atípico; Thrombotic microangiopathy