title: Biological activities of Zn(II)-S-methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects.
abstract: The antidepressant effect of simple Zn(II) salts has been proved in several animal models of depression. In this study, a coordination metal complex of Zn(II) having a sulfur containing ligand is tested as antidepressant for the first time. Forced swimming test method on male Wistar rats shows a decrease in the immobility and an increase in the swimming behavior after treatment with [Zn(S-Met)2] (S-Met=S-methyl-l-cysteine) being more effective and remarkable than ZnCl2. The thiobarbituric acid and the pyranine consumption (hydroxyl and peroxyl radicals, respectively) methods were applied to evaluate the antioxidant activity of S-Met and [Zn(S-Met)2] showing evidence of attenuation of hydroxyl but not peroxyl radicals activities. UV-vis studies on the inhibition of acid phosphatase enzyme (AcP) demonstrated that S-methyl-l-cysteine did not produce any effect but, in contrast, [Zn(S-Met)2] complex behaved as a moderate inhibitor. Finally, bioavailability studies were performed by fluorescence spectroscopy denoting the ability of the albumin to transport the complex.
authors.affiliation: a Instituto de Bioquímica y Farmacia del IByF-CENIIT-UNLaR (Centro de Investigación e Innovación Tecnológica), Av Luis Vernet y Apostol Felipe , La Rioja , Argentina .
authors.forename: Graciela E
authors.initials: GE
authors.lastname: Escudero
authors.affiliation: b Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), FCE-UNLP , La Plata , Argentina , and.
authors.forename: Nancy
authors.initials: N
authors.lastname: Martini
authors.affiliation: b Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), FCE-UNLP , La Plata , Argentina , and.
authors.forename: Khalil
authors.initials: K
authors.lastname: Jori
authors.affiliation: b Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), FCE-UNLP , La Plata , Argentina , and.
authors.forename: Nadir
authors.initials: N
authors.lastname: Jori
authors.affiliation: a Instituto de Bioquímica y Farmacia del IByF-CENIIT-UNLaR (Centro de Investigación e Innovación Tecnológica), Av Luis Vernet y Apostol Felipe , La Rioja , Argentina .
authors.forename: Nahuel R
authors.initials: NR
authors.lastname: Maresca
authors.affiliation: c Instituto de Biotecnología del CENIIT-UNLaR (Centro de Investigación e Innovación Tecnológica), Av Luis Vernet y Apostol Felipe , La Rioja , Argentina.
authors.forename: Carlos H
authors.initials: CH
authors.lastname: Laino
authors.affiliation: b Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), FCE-UNLP , La Plata , Argentina , and.
authors.forename: Luciana G
authors.initials: LG
authors.lastname: Naso
authors.affiliation: b Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), FCE-UNLP , La Plata , Argentina , and.
authors.forename: Patricia A M
authors.initials: PA
authors.lastname: Williams
authors.affiliation: b Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), FCE-UNLP , La Plata , Argentina , and.
authors.forename: Evelina G
authors.initials: EG
authors.lastname: Ferrer
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming; D015032:Zinc / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D015032:Zinc; D003545:Cysteine; C017507:mecysteine
keywords: Antidepressant effect; S-methyl-cysteine; Zn(II) complex; antioxidant activity; phosphatase inhibitory effects