title: [The influence of sodium bicarbonate combined with ulinastatin on cholinesterase activity for patients with acute phoxim pesticide poisoning].
abstract: OBJECTIVE
  To observe the effect of sodium bicarbonate combined with ulinastatin on cholinesterase activity for patients with acute phoxim pesticide poisoning.
  
  
  METHODS
  A total of 67 eligible patients with acute phoxim pesticide poisoning, Who were admitted to the emeryency department of hospital from March 2011 to February 2014, Acording to different treatments au patients were randomly divided into the conventional treatment group (n=34) and the sodium bicarbonate+ulinastatin group (n=35) . The conventional treatment group were given thorough gastric lavage with water, the sodium bicarbonate + ulinastatin group were given gastric lavage with 2% sodium bicarbonate solution. Both groups were given such treatments as catharsis, administration of oxygen, fluid infusion, diuresis, and antidotes such as atropine and pralidoxime methylchloride. On the basis of comprehensive treatment, people in the sodium bicarbonate+ulinastatin group were given 5% sodium bicarbonate injection and ulinastatin. The clinical effect of the two groups were compared.
  
  
  RESULTS
  The serum cholinesterase activity of the sodium bicarbonate+ulinastatin group was significantly higher than the conventional treatment group from the 5th day, and the difference was statistically significant (P<0.05) . The total atropine dosage, total pralidoxime methylchloride dosage and hospitalization days were better than the conventional treatment group, and the differences were statistically significant (P<0.05) . The difference in the time of atropinization between the two groups was not statistically significant (P>0.05) . The results of arterial blood pH, HCO3- of the sodium bicarbonate + ulinastatin group were higher than the conventional treatment group, and the difference of HCO3- at the 10th day was statistically significant (P<0.05) .
  
  
  CONCLUSIONS
  Sodium bicarbonate combined with ulinastatin can improve the therapeutic effect and reduce complications in the treatment of acute phoxim pesticide poisoning, and have beneficial effects on the recovery of cholinesterase activity.
authors.affiliation: Liaocheng People's Hospital, Sandong Province Liaocheng 252000, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.forename: Lanju
authors.initials: L
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Xiao
authors.forename: Baoquan
authors.initials: B
authors.lastname: Sun
authors.forename: Xianbao
authors.initials: X
authors.lastname: Zou
authors.forename: Dongmei
authors.initials: D
authors.lastname: Gao
authors.forename: Xiandong
authors.initials: X
authors.lastname: Jian
mesh_terms: D001285:Atropine / Q000627:therapeutic use; D002802:Cholinesterases / Q000378:metabolism; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D062025:Organophosphate Poisoning / Q000188:drug therapy*; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D010575:Pesticides / Q000506:poisoning; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D017693:Sodium Bicarbonate / Q000627:therapeutic use*
chemical_list: D006023:Glycoproteins; D009946:Organothiophosphorus Compounds; D010575:Pesticides; D011220:Pralidoxime Compounds; C003135:phoxim; D001285:Atropine; D017693:Sodium Bicarbonate; D002802:Cholinesterases; C028665:urinastatin; C028797:pralidoxime