title: Mediator and TREX-2: Emerging links between transcription initiation and mRNA export.
abstract: Nuclear pore proteins interact dynamically with chromatin to regulate gene activities. A key question is how nucleoporin interactions mechanistically alter a gene's intranuclear position and transcriptional output. We reported recently on a direct interaction between the nuclear pore-associated TREX-2 complex and promoter-bound Mediator. This highlights how nuclear-pore associated adaptors gain regulatory access to the core transcription machinery. In this Extra View, we discuss an additional implication that arises from our work and the recent literature: how promoter elements may regulate mRNA metabolism beyond transcription initiation.
authors.affiliation: a Max F. Perutz Laboratories , Medical University of Vienna , Vienna Biocenter Campus (VBC) , Vienna, Austria.
authors.forename: Tobias
authors.initials: T
authors.lastname: Schubert
authors.affiliation: a Max F. Perutz Laboratories , Medical University of Vienna , Vienna Biocenter Campus (VBC) , Vienna, Austria.
authors.forename: Alwin
authors.initials: A
authors.lastname: Köhler
mesh_terms: D004706:Endodeoxyribonucleases / Q000378:metabolism*; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics; D012319:RNA Polymerase II / Q000378:metabolism; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D061785:Transcription Initiation, Genetic
chemical_list: D012333:RNA, Messenger; D012319:RNA Polymerase II; D004706:Endodeoxyribonucleases
keywords: TREX-2; mediator; nuclear pore complex; transcription coupled mRNA export;