title: Acyclovir-loaded sorbitan esters-based organogel: development and rheological characterization.
abstract: Herein, a nanoemulsion-based organogel (NEOG) system loaded with acyclovir has been developed for the effective treatment of herpes simplex virus infection via topical delivery. Pseudo-ternary phase diagram exhibited increase in non-birefrigent, optically isotropic region of organogel with Smix (Kw) ratio. The NEOG C showed good storage (G') and loss moduli (G″), and more compact network structures. Gel-sol transition temperature (Tg) and fractal dimension (Df) of NEOG system revealed increased density of the tubular network with Kw. Hence, high gelling ability of the developed NEOG system may attribute to the combination of sustained and site-specific delivery of drugs.
authors.affiliation: a Pharmaceutical Research Project Laboratory, Department of Pharmaceutical Sciences , Dr. Hari Singh Gour Vishwavidyalaya , Sagar , Madhya Pradesh , India.|b Pharmaceutical Research Project Laboratory , Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University) , Bilaspur , Chhattisgarh , India.
authors.forename: Kuldeep
authors.initials: K
authors.lastname: Rajpoot
mesh_terms: D000212:Acyclovir / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001692:Biological Transport; D004337:Drug Carriers; D004339:Drug Compounding; D065546:Drug Liberation; D004655:Emulsions; D004952:Esters; D005782:Gels / Q000737:chemistry*; D006601:Hexoses / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009226:Myristates / Q000737:chemistry* / Q000378:metabolism; D010539:Permeability; D044367:Phase Transition; D012212:Rheology; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013552:Swine; D046509:Tissue Culture Techniques; D014783:Viscosity
chemical_list: D000998:Antiviral Agents; D004337:Drug Carriers; D004655:Emulsions; D004952:Esters; D005782:Gels; D006601:Hexoses; D009226:Myristates; C008205:isopropyl myristate; C009298:sorbitan monostearate; D000212:Acyclovir
keywords: Acyclovir; herpes simplex virus; isopropyl myristate; nanoemulsion; organogel; rheology; sorbitan monostearate; topical