title: Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer.
abstract: Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of microRNAs in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of malignancies, including gastric cancer. This review summarizes the current knowledge about the miRNAs' characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant gastric cancer.
authors.affiliation: Molecular Pathology Laboratory, Department of Pathology, CEGIN-BIOREN, Universidad de La Frontera, Avenida Alemania 0458, 3th Floor, Temuco 4810296, Chile. ismael.riquelme.contreras@gmail.com.
authors.forename: Ismael
authors.initials: I
authors.lastname: Riquelme
authors.affiliation: School of Health Sciences, Universidad Católica de Temuco, Manuel Montt 56, Temuco 4813302, Chile. pablolete@gmail.com.
authors.forename: Pablo
authors.initials: P
authors.lastname: Letelier
authors.affiliation: Molecular Pathology Laboratory, Department of Pathology, CEGIN-BIOREN, Universidad de La Frontera, Avenida Alemania 0458, 3th Floor, Temuco 4810296, Chile. a.riffo.c@gmail.com.
authors.forename: Angela L
authors.initials: AL
authors.lastname: Riffo-Campos
authors.affiliation: Molecular Pathology Laboratory, Department of Pathology, CEGIN-BIOREN, Universidad de La Frontera, Avenida Alemania 0458, 3th Floor, Temuco 4810296, Chile. brebi.mieville@gmail.com.
authors.forename: Priscilla
authors.initials: P
authors.lastname: Brebi
authors.affiliation: Department of Pathology, UC Centre for Investigational Oncology (CITO), Advanced Centre for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Marcoleta 377, 7th Floor, Santiago 8330024, Chile. jcroas@gmail.com.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Roa
mesh_terms: D000818:Animals; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D035683:MicroRNAs
keywords: drug resistance; gastric cancer; microRNAs