title: Role of Antifungal Susceptibility Testing in Non-Aspergillus Invasive Mold Infections.
abstract: No clinical breakpoints are available to delineate antifungal drug efficacy in non-Aspergillus invasive mold infections (NAIMIs). In this analysis of 39 NAIMI episodes, the MIC of the first-line antifungal drug was the most important predictor of therapeutic response. For amphotericin B, an MIC of ≤0.5 μg/ml was significantly associated with better 6-week outcomes.
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA frederic.lamoth@chuv.ch.|Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.|Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.|Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lamoth
authors.affiliation: Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Lauro
authors.initials: L
authors.lastname: Damonti
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.|Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Alexander
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D000072742:Invasive Fungal Infections / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B