title: Evaluation of single right atrial volume and function with magnetic resonance imaging in children with hypoplastic left heart.
abstract: BACKGROUND
  Standardized methods to evaluate atrial properties in single ventricles are lacking.
  
  
  OBJECTIVE
  To determine the feasibility of quantifying right atrial volumes and function in hypoplastic left heart using MRI.
  
  
  METHODS
  We studied 15 infants with hypoplastic left heart prior to Glenn surgery (mean age 4.2 months [standard deviation 0.3]) who underwent cardiac MRI with evaluation of atrial volumes and emptying fraction using monoplane two-chamber, monoplane four-chamber, and biplane methods, all of which were compared to the atrial short-axial oblique stack method. We compared atrial end-diastolic volume, end-systolic volume and emptying fraction among these methods. We analyzed reproducibility of the methods using Bland‒Altman plots.
  
  
  RESULTS
  Both four-chamber and biplane methods showed high correlations for atrial end-diastolic volume (r = 0.7 and r = 0.8, respectively; P < 0.01) and end-systolic volume (r = 0.8 and r = 0.9, respectively; P < 0.01) with small mean differences (-0.2 ± 2.9 standard deviation [SD] ml and -0.8 ± 1.6 ml, respectively, for atrial end-diastolic volume and -0.8 ± 1.5 ml and -0.9 ± 0.9 ml, respectively, for atrial end-systolic volume). The short-axial oblique method was the most reproducible, followed by the four-chamber method.
  
  
  CONCLUSIONS
  MRI assessment of atrial volume and function is feasible in hypoplastic left heart and might provide further insight into single-ventricle mechanics.
authors.affiliation: Faculty of Medicine and Dentistry, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada. cvijarnsorn@yahoo.com.|Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand. cvijarnsorn@yahoo.com.
authors.forename: Chodchanok
authors.initials: C
authors.lastname: Vijarnsorn
authors.affiliation: Section of Pediatric Cardiology, Department of Pediatrics, Department of Pediatrics, Alberta Children's Hospital, Calgary, AB, Canada.
authors.forename: Kimberley
authors.initials: K
authors.lastname: Myers
authors.affiliation: Section of Pediatric Cardiology, Department of Pediatrics, Department of Pediatrics, Alberta Children's Hospital, Calgary, AB, Canada.
authors.forename: David J
authors.initials: DJ
authors.lastname: Patton
authors.affiliation: Faculty of Medicine and Dentistry, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Noga
authors.affiliation: Faculty of Medicine and Dentistry, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Crawley
authors.affiliation: Faculty of Medicine and Dentistry, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
authors.forename: Edythe
authors.initials: E
authors.lastname: Tham
mesh_terms: D005240:Feasibility Studies; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000000981:diagnostic imaging*; D007090:Image Interpretation, Computer-Assisted; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D016896:Treatment Outcome
keywords: Atrial volume; Children; Hypoplastic left heart; Magnetic resonance imaging; Single ventricle