title: Comparative Pharmacokinetics of Ginsenoside Rg3 and Ginsenoside Rh2 after Oral Administration of Ginsenoside Rg3 in Normal and Walker 256 Tumor-bearing Rats.
abstract: BACKGROUND
  Ginseng is Chinese traditional herbal medicine, and the ginsenoside Rg3 is the main bioactive ingredient for the anti-tumor effect. However, there is no study on pharmacokinetics (PKs) of ginsenoside Rg3 and its main metabolite after oral ginsenoside Rg3 in tumor-bearing plasma. The aim of this study was to investigate the PK profiles of ginsenoside Rg3 and ginsenoside Rh2 after oral administration of pure ginsenoside Rg3 were administered, and compare the difference of the PK profiles between normal and Walker 256 tumor-bearing rats.
  
  
  METHODS
  The concentrations of two ginsenosides in plasma were determined by using a simple and rapid high-performance liquid chromatography. All the rats were divided randomly into two groups (Walker 256 tumor-bearing and normal groups). Each group received oral administration of 50 mg/kg ginsenoside Rg3.
  
  
  RESULTS
  The results showed that ginsenoside Rh2, possibly as a glycosylation hydrolysis product of ginsenoside Rg3, were found in plasma after oral administration of ginsenoside Rg3 to rats. Ginsenoside Rg3 had shown better absorption than ginsenoside Rh2, whether the oral administration of ginsenoside Rg3, normal rats showed better absorption than tumor-bearing rats.
  
  
  CONCLUSIONS
  The PKs properties of the ginsenoside Rg3 and ginsenoside Rh2 differed between tumor-bearing rats and normal rats, including area under the plasma level/time curve and concentration maximum (P < 0.05).
  
  
  CONCLUSIONS
  Ginsenoside Rh2 was found in plasma after oral administration of ginsenoside Rg3 to ratsHPLC could be used to determine simultaneously, the concentration of ginsenoside Rg3 and ginsenoside Rh2 in rat plasma after oral administration of ginsenoside Rg3Normal rats showed better absorption than tumor-bearing rats after oral administration of ginsenoside Rg3.0.
authors.affiliation: Department of Chinese Medicine Analysis, Liaoning University of Traditional Chinese Medicine, 77 Life One Road, DD Port, Dalian 116600, China.
authors.forename: He
authors.initials: H
authors.lastname: Fan
authors.affiliation: Institute of Traditional Chinese Medicine, Liaoning Institute for Drug Control, 7 Congshan West Road, Shenyang 110036, China.
authors.forename: Sun
authors.initials: S
authors.lastname: Xiao-Ling
authors.affiliation: Department of Chinese Medicine Analysis, Liaoning University of Traditional Chinese Medicine, 77 Life One Road, DD Port, Dalian 116600, China.
authors.forename: Su
authors.initials: S
authors.lastname: Yaliu
authors.affiliation: Dalian Fusheng Natural Drug Development Co., Ltd, 5 Tiexi Middle Road, Development District, Dalian 116600, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ming-Ming
authors.affiliation: Dalian Fusheng Natural Drug Development Co., Ltd, 5 Tiexi Middle Road, Development District, Dalian 116600, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.affiliation: Department of Chinese Medicine Analysis, Liaoning University of Traditional Chinese Medicine, 77 Life One Road, DD Port, Dalian 116600, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xian-Sheng
authors.affiliation: Dalian Fusheng Natural Drug Development Co., Ltd, 5 Tiexi Middle Road, Development District, Dalian 116600, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Li
keywords: Ginsenoside Rg3; ginsenoside Rh2; high-performance liquid chromatography; pharmacokinetic