title: Controlled release of curcumin from poly(HEMA-MAPA) membrane.
abstract: In this work, poly(HEMA-MAPA) membranes were prepared by UV-polymerization technique. These membranes were characterized by SEM, FTIR, and swelling studies. Synthesized membranes had high porous structure. These membranes were used for controlled release of curcumin which is already used as folk remedy and used as drug for some certain diseases and cancers. Curcumin release was investigated for various pHs and temperatures. Optimum drug release yield was found to be as 70% at pH 7.4 and 37 °C within 2 h period. Time-depended release of curcumin was also investigated and its slow release from the membrane demonstrated within 48 h.
authors.affiliation: a Department of Biochemistry , Ege University , İzmir , Turkey.
authors.forename: Müşerref
authors.initials: M
authors.lastname: Caka
authors.affiliation: a Department of Biochemistry , Ege University , İzmir , Turkey.
authors.forename: Ceren
authors.initials: C
authors.lastname: Türkcan
authors.affiliation: b Department of Chemistry , Adnan Menderes University , Aydın , Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Aktaş Uygun
authors.affiliation: c Koçarlı Vocational and Training School , Adnan Menderes University , Aydın , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Uygun
authors.affiliation: a Department of Biochemistry , Ege University , İzmir , Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Akgöl
authors.affiliation: d Department of Chemistry , Hacettepe University , Ankara , Turkey.
authors.forename: Adil
authors.initials: A
authors.lastname: Denizli
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism; D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000528:radiation effects; D004339:Drug Compounding; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry*; D010649:Phenylalanine / Q000737:chemistry*; D058105:Polymerization; D016062:Porosity; D012996:Solutions; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D008689:Methacrylates; D012996:Solutions; D010649:Phenylalanine; C005044:hydroxyethyl methacrylate; D003474:Curcumin
keywords: Curcumin; drug release; membrane; poly(HEMA-MAPA)