title: Matrix ageing and vascular impacts: focus on elastin fragmentation.
abstract: Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular diseases. This review highlights ECM alterations occurring during vascular ageing with a specific focus on elastin fragmentation and also the contribution of elastin-derived peptides (EDP) in age-related vascular complications. Moreover, current and new pharmacological strategies aiming at minimizing elastin degradation, EDP generation, and associated biological effects are discussed. These strategies may be of major relevance for preventing and/or delaying vascular ageing and its complications.
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Duca
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Blaise
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Romier
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Laffargue
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Gayral
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Hassan
authors.initials: H
authors.lastname: El Btaouri
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Kawecki
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Guillot
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Martiny
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Debelle
authors.affiliation: Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France pascal.maurice@univ-reims.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Maurice
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004549:Elastin / Q000378:metabolism*; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D065089:Glycoside Hydrolase Inhibitors / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism*; D059748:Proteolysis; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects; D014652:Vascular Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
chemical_list: D002317:Cardiovascular Agents; D065089:Glycoside Hydrolase Inhibitors; D010446:Peptide Fragments; D015842:Serine Proteinase Inhibitors; D004549:Elastin; C486385:NEU1 protein, human; D009439:Neuraminidase; D010196:Pancreatic Elastase
keywords: Ageing; Elastin fragmentation; Extracellular matrix remodelling; Vascular diseases