title: Signal molecules during the organism development: Central and peripheral sources of noradrenaline in rat ontogenesis.
abstract: Using the method of high performance liquid chromatography with electrochemical detection, the age dynamics of the content of noradrenaline (NA) in the brain, adrenal gland, and the organ of Zuckerkandl in prenatal (18th and 21st days of embryogenesis) and early postnatal (3, 7, 15, and 30th days) periods of development was studied. The potential contribution of these organs to the formation of physiologically active concentration of noradrenalin in the blood was also assessed. The results suggest that, during the development of the organism, the activity of the sources of noradrenaline in the general circulation changes, which gives a reason to assume the existence of humoral interaction between NA-producing organs in the perinatal period of ontogenesis.
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia. aliya_mr89@mail.ru.
authors.forename: A R
authors.initials: AR
authors.lastname: Murtazina
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
authors.forename: Y O
authors.initials: YO
authors.lastname: Nikishina
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
authors.forename: N S
authors.initials: NS
authors.lastname: Bondarenko
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
authors.forename: A Ja
authors.initials: AJ
authors.lastname: Sapronova
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ugrumov
mesh_terms: D000311:Adrenal Glands / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D006128:Growth; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D010220:Para-Aortic Bodies / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction
chemical_list: D009638:Norepinephrine