title: Role of oral pentosan polysulphate in the reduction of local side effects of BCG therapy in patients with non-muscle-invasive bladder cancer: a pilot study.
abstract: OBJECTIVE
  To assess the role of oral pentosan polysulphate (PPS) in the reduction of bacille Calmette-Guérin (BCG)-related local side effects in patients with high grade Ta/T1 non-muscle-invasive bladder cancer (NMIBC).
  
  
  METHODS
  A total of 32 symptomatic patients receiving BCG instillation were randomized into three groups: group A received placebo (vitamin B complex tablet) thrice daily; group B received PPS 100 mg thrice daily; and group C received PPS 100 mg once daily and placebo (vitamin B complex tablet) twice daily for 6 weeks. A visual analogue scale (VAS) score for bladder pain, Overactive Bladder-Validated 8 Question Screener (OAB-V8) scores and dysuria were evaluated in the three groups before and during each weekly visit for BCG instillation.
  
  
  RESULTS
  The mean ± sd post-treatment VAS scores were significantly lower in groups B (4.4 ± 1.2) and C (5.8 ± 0.8) than in group A (8 ± 0.4). In addition, the post-treatment VAS score was significantly lower in group B than in group C (P<0.01). The mean post-treatment OAB-V8 score was significantly lower only in group B (decreased from 15.5 to 9.7). Dysuria decreased in groups B and C but persisted in group A.
  
  
  CONCLUSIONS
  The present study shows that oral PPS (100 mg) thrice daily is effective in relieving BCG-related local side effects.
authors.affiliation: Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India. drsureshyadav7@gmail.com.
authors.forename: Suresh
authors.initials: S
authors.lastname: Yadav
authors.affiliation: Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
authors.forename: Vinay
authors.initials: V
authors.lastname: Tomar
authors.affiliation: Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
authors.forename: Sher Singh
authors.initials: SS
authors.lastname: Yadav
authors.affiliation: Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
authors.forename: Shivam
authors.initials: S
authors.lastname: Priyadarshi
authors.affiliation: Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
authors.forename: Indraneel
authors.initials: I
authors.lastname: Banerjee
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000284:Administration, Oral; D001500:BCG Vaccine / Q000009:adverse effects*; D004311:Double-Blind Method; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth; D009361:Neoplasm Invasiveness; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage*; D010865:Pilot Projects; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D010426:Pentosan Sulfuric Polyester
keywords: bacille Calmette-Guérin; dysuria; intravesical instillation; pentosan polysulphate; visual analogue scale score