title: A single bout of resistance exercise improves memory consolidation and increases the expression of synaptic proteins in the hippocampus.
abstract: Over the past decade, several studies have indicated that chronic resistance exercise (i.e., strength training, weight lifting, etc.) is beneficial for brain health and cognitive function. However, little is known about the effects of a single bout of resistance exercise on brain function, particularly on memory consolidation. Therefore, the purpose of the present study is to examine the effects of a single bout of resistance exercise applied immediately after the training of fear conditioning on memory consolidation and on the expression of IGF-1 and synaptic proteins in the hippocampus. Male Wistar rats were familiarized with climbing a ladder without a load for 3 days and randomly assigned into control (CTL) and resistance exercise (RES) groups. The RES group was subjected to a single bout of resistance exercise applied immediately after fear conditioning training. Subsequently, the animals were tested for contextual (24 h) and tone (48 h) fear memory. Another group of animals were subjected to a single bout of resistance exercise and euthanized 24 h later for hippocampal analysis of IGF-1 and synaptic proteins (synapsin I, synaptophysin, and PSD-95). The exercised rats improved contextual but not tone fear memory. Hippocampal IGF-1 was not altered by resistance exercise. However, the levels of synapsin I, synaptophysin, and PSD-95 increased significantly in the RES group. The results suggested that a single bout of resistance exercise applied immediately after fear conditioning could improve contextual memory, probably through the activation of pre- and postsynaptic machinery required for memory consolidation. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Physiology, Universidade Federal De São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Jansen
authors.initials: J
authors.lastname: Fernandes
authors.affiliation: Department of Psychobiology, Universidade Federal De São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Juliana Carlota Kramer
authors.initials: JC
authors.lastname: Soares
authors.affiliation: Department of Physiology, Universidade Federal De São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Luiz Guilherme Zaccaro
authors.initials: LG
authors.lastname: do Amaral Baliego
authors.affiliation: Department of Physiology, Universidade Federal De São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Ricardo Mario
authors.initials: RM
authors.lastname: Arida
mesh_terms: D000818:Animals; D001307:Auditory Perception / Q000502:physiology; D015153:Blotting, Western; D003213:Conditioning, Psychological / Q000502:physiology*; D000076122:Disks Large Homolog 4 Protein / Q000378:metabolism; D004597:Electroshock; D004797:Enzyme-Linked Immunosorbent Assay; D005239:Fear / Q000502:physiology; D046352:Freezing Reaction, Cataleptic; D006624:Hippocampus / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D000069077:Memory Consolidation / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D011897:Random Allocation; D017208:Rats, Wistar; D016704:Synapsins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D000076122:Disks Large Homolog 4 Protein; C501449:Dlg4 protein, rat; D016704:Synapsins; D016708:Synaptophysin; C569016:Syp protein, rat; C548904:insulin-like growth factor-1, rat; D007334:Insulin-Like Growth Factor I
keywords: IGF-1; brain; memory; resistance exercise; synaptic proteins