title: The effects of α-tocopherol administration in chronically lead exposed workers.
abstract: The aim of the study was to investigate whether α-tocopherol supplementation for workers who are chronically exposed to lead would normalize/improve the values of parameters that are associated with the lead-induced oxidative stress. Study population included chronically lead exposed males who were divided into two groups. Workers in the first group (reference group) were not given any antioxidants, while workers in the second group (αT group) received supplementation with α-tocopherol. After treatment, the blood lead and leukocyte malondialdehyde levels decreased significantly in the αT group compared to the baseline levels and reference group. However, the erythrocyte malondialdehyde, conjugated dienes, and lipofuscin levels significantly increased compared to the baseline levels. The glutathione level significantly increased compared with the baseline. Effects of supplementation with α-tocopherol on oxidative damage were not satisfactory. Therefore, there is no reason to administer α-tocopherol to workers chronically exposed to lead as a prophylaxis of lead poisoning.
authors.affiliation: Dept. of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. Electronic address: kaslav@mp.pl.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Kasperczyk
authors.affiliation: Dept. of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Dobrakowski
authors.affiliation: Dept. of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kasperczyk
authors.affiliation: Higher School of Medicine in Sosnowiec, Wojska Polskiego 6, 41-200 Sosnowiec, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Nogaj
authors.affiliation: Dept. of Department of Physical Hazards Work Physiology and Ergonomics Institute of Occupational Medicine and Environmental Health in Sosnowiec, ul. Kościelna 13, 41-200 Sosnowiec, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Boroń
authors.affiliation: Dept. of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Birkner
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D019587:Dietary Supplements; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D024502:alpha-Tocopherol / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D005978:Glutathione; D024502:alpha-Tocopherol
keywords: Alfa-tocopherol; Antioxidants; Lead poisoning; Lipid peroxidation; Oxidative stress