title: T1mapping of the mouse brain following fractionated manganese administration using MP2RAGE.
abstract: With the increasing development of transgenic mouse models of neurodegenerative diseases allowing improved understanding of the underlying mechanisms of these disorders, robust quantitative mapping techniques are also needed in rodents. MP2RAGE has shown great potential for structural imaging in humans at high fields. In the present work, MP2RAGE was successfully implemented at 9.4T and 14.1T. Following fractionated injections of MnCl2, MP2RAGE images were acquired allowing simultaneous depiction and T1mapping of structures in the mouse brain at both fields. In addition, T1maps demonstrated significant T1shortenings in different structures of the mouse brain (p < 0.0008 at 9.4T, p < 0.000001 at 14.1T). T1values recovered to the levels of saline-injected animals 1 month after the last injection except in the pituitary gland. We believe that MP2RAGE represents an important prospective translational tool for further structural MRI.
authors.affiliation: CIBM-AIT Core, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Luc
authors.initials: L
authors.lastname: Driencourt
authors.affiliation: CIBM-AIT Core, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Carola Jacqueline
authors.initials: CJ
authors.lastname: Romero
authors.affiliation: CIBM-AIT Core, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Mario
authors.initials: M
authors.lastname: Lepore
authors.affiliation: CIBM-AIT Core, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Florent
authors.initials: F
authors.lastname: Eggenschwiler
authors.affiliation: CIBM-AIT Core, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Reynaud
authors.affiliation: CIBM-AIT Core, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. nathalie.just@ukmuenster.de.|Institut für Klinische Radiologie, Translational Research Imaging Center (TRIC), Albert-Schweitzer-Campus 1, Gebäude A16, Anfahrt: Waldeyerstr. 1, 48149, Münster, Germany. nathalie.just@ukmuenster.de.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Just
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods*; D002712:Chlorides; D003287:Contrast Media; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000008:administration & dosage*; D017895:Manganese Compounds; D051379:Mice; D008810:Mice, Inbred C57BL; D059629:Signal-To-Noise Ratio
chemical_list: D002712:Chlorides; D003287:Contrast Media; D017895:Manganese Compounds; D008345:Manganese; C025340:manganese chloride
keywords: High resolution; MEMRI; Mouse; T1 relaxation; Translational