title: [Intravesical Recurrence of Small Cell Carcinoma of the Ureter: A Case Report].
abstract: A 63-year-old man who presented with asymptomatic gross hematuria was referred to our hospital. Left ureteral tumor (cT3N0M0) was diagnosed and left nephroureterectomy was performed. Pathological examination revealed urothelial carcinoma and small cell carcinoma with local invasion (pT3). The patient was treated with three cycles of adjuvant chemotherapy with gemcitabine and cisplatin. Three months after the chemotherapy, cystoscopy showed an intravesical recurrence of the tumor. Transurethral resection was performed and histopathological examination revealed small cell carcinoma (pT1). We recommended a cystectomy and neoadjuvant chemotherapy with etoposide and carboplatin according to the standard care of small cell carcinoma of bladder. However, the patient refused to undergo cystectomy and desired to preserve his bladder. Therefore, after two cycles of chemotherapy with etoposide and carboplatin, transurethral resection was performed to examine the presence of the residual tumor instead of immediate cystectomy. Because of no residual tumor, another two cycles of chemotherapy were added instead of a cystectomy. There is no evidence of recurrence seven months after the chemotherapy.
authors.affiliation: The Department of Urology, Kinki Central Hospital of Mutual Aid Association of Public Teachers.
authors.forename: Norichika
authors.initials: N
authors.lastname: Ueda
authors.affiliation: The Department of Urology, Kinki Central Hospital of Mutual Aid Association of Public Teachers.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: The Department of Urology, Kinki Central Hospital of Mutual Aid Association of Public Teachers.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Arai
authors.affiliation: The Department of Urology, Kinki Central Hospital of Mutual Aid Association of Public Teachers.
authors.forename: Masahito
authors.initials: M
authors.lastname: Honda
authors.affiliation: The Department of Pathology, Kinki Central Hospital of Mutual Aid Association of Public Teachers.
authors.forename: Kyotaro
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012008:Recurrence; D014516:Ureteral Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000556:secondary*
chemical_list: D005047:Etoposide; D016190:Carboplatin