title: A Primer on the Bayesian Approach to High-Density Single-Molecule Trajectories Analysis.
abstract: Tracking single molecules in living cells provides invaluable information on their environment and on the interactions that underlie their motion. New experimental techniques now permit the recording of large amounts of individual trajectories, enabling the implementation of advanced statistical tools for data analysis. In this primer, we present a Bayesian approach toward treating these data, and we discuss how it can be fruitfully employed to infer physical and biochemical parameters from single-molecule trajectories.
authors.affiliation: Laboratoire Physico-Chimie, Institut Curie, PSL Research University, Paris, France; Department of Radiation Oncology, Sorbonne Universités, Paris, France; Physics of Biological Systems, Institut Pasteur, Paris, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Beheiry
authors.affiliation: Division of Medical Physics, Stanford University School of Medicine, Palo Alto, California.
authors.forename: Silvan
authors.initials: S
authors.lastname: Türkcan
authors.affiliation: Laboratoire d'Optique et Biosciences, Ecole Polytechnique, Université Paris-Saclay, Palaiseau, France.
authors.forename: Maximilian U
authors.initials: MU
authors.lastname: Richly
authors.affiliation: Biologie Cellulaire de la Synapse, École Normale Supérieure, PSL Research University, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Triller
authors.affiliation: Laboratoire d'Optique et Biosciences, Ecole Polytechnique, Université Paris-Saclay, Palaiseau, France.
authors.forename: Antigone
authors.initials: A
authors.lastname: Alexandrou
authors.affiliation: Laboratoire Physico-Chimie, Institut Curie, PSL Research University, Paris, France; Department of Radiation Oncology, Sorbonne Universités, Paris, France; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia.
authors.forename: Maxime
authors.initials: M
authors.lastname: Dahan
authors.affiliation: Physics of Biological Systems, Institut Pasteur, Paris, France; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia. Electronic address: jbmasson@pasteur.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Masson
mesh_terms: D001499:Bayes Theorem; D002352:Carrier Proteins / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D016013:Likelihood Functions; D008565:Membrane Proteins / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; C073441:gephyrin