title: New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens.
abstract: In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium Moorea producens was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A (1), two new nucleoside derivatives, 3-acetyl-2'-deoxyuridine (2) and 3-phenylethyl-2'-deoxyuridine (3), along with the previously reported compounds thymidine (4) and 2,3-dihydroxypropyl heptacosanoate (5). The structures of the compounds were determined by different spectroscopic studies (UV, IR, 1D, 2D NMR, and HRESIMS), as well as comparison with the literature data. Compounds 1-5 showed variable cytotoxic activity against three cancer cell lines.
authors.affiliation: Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. dyoussef@kau.edu.sa.
authors.forename: Diaa T A
authors.initials: DT
authors.lastname: Youssef
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia. sribrahim@taibahu.edu.sa.|Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. sribrahim@taibahu.edu.sa.
authors.forename: Sabrin R M
authors.initials: SR
authors.lastname: Ibrahim
authors.affiliation: Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia. lshalla@kau.edu.sa.|Suez Canal University Hospital, Suez Canal University, Ismailia 41522, Egypt. lshalla@kau.edu.sa.
authors.forename: Lamiaa A
authors.initials: LA
authors.lastname: Shaala
authors.affiliation: Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. gamals2001@yahoo.com.|Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt. gamals2001@yahoo.com.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia. zmbanjar@yahoo.com.
authors.forename: Zainy M
authors.initials: ZM
authors.lastname: Banjar
mesh_terms: D045744:Cell Line, Tumor; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000458:Cyanobacteria / Q000737:chemistry*; D006801:Humans; D019156:Indian Ocean; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002554:Cerebrosides; D009705:Nucleosides
keywords: Moorea producens; cerebroside; cytotoxic activity; marine cyanobacterium; nucleosides