title: Interplay between myeloid-derived suppressor cells (MDSCs) and Th17 cells: foe or friend?
abstract: Myeloid-derived suppressor cells (MDSCs) and Th17 cells were first discovered in the fields of cancer and autoimmunity, respectively. In recent years, their activities have been explored in other biological and pathological conditions, such as infective diseases and solid organ transplantation. However, the interplay between MDSCs and Th17 cells and the mechanism of their interaction remain obscure. This review summarized and analyzed the relationship between MDSCs and Th17 cells, both of which participate in tumor, autoimmune disease, infection and other conditions. In tumors, the increase in MDSCs at the tumor site is usually accompanied by the accumulation of Th17 cells. However, their relationship is inconsistent in different tumors. In arthritic mice or rheumatoid arthritis (RA) patients, an increase in MDSCs, which could ameliorate disease symptoms, causes decreased IL-17A gene expression and Th17 cells accumulation. Furthermore, we concluded that the interaction between MDSCs and Th17 cells is mainly mediated by cytokines. However, the mechanisms require further investigation. Determining the details of their interplay will provide a better understanding of immune networks and could lead to the development of immunotherapeutic strategies in the future.
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wen
authors.affiliation: Department of Oncology, First Affiliated Hospital of Shihezi University School of Medicine, Shihezi City, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Shou
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Baoqing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Changqian
authors.initials: C
authors.lastname: Bao
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Division of Gastroenterology, Xiangya Second Hospital, Central South University, Hunan, People's Republic of China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Tingbo
authors.initials: T
authors.lastname: Liang
authors.affiliation: Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Gong
mesh_terms: D000818:Animals; D006801:Humans; D000072737:Myeloid-Derived Suppressor Cells; D058504:Th17 Cells
keywords: Th17 cells; autoimmunity; cytokine; myeloid-derived suppressor cells; tumor