title: Recombinant 1F9 spidroin microgels for murine full-thickness wound repairing.
abstract: The study of the stimulating effect of the microgels (MGs) based on recombinant 1F9 spidroin on the regeneration of the deep skin wound in mice was carried out. The use of spidroin MGs was shown to increase significantly the quality of healing compared to the control. The introduction of the MG in the wound edges led to recovery of all the structural elements of the skin: the epidermis, the dermis, including vascular and nervous network, in the periphery of the wound underlying muscles, and skin appendages (sebaceous and sweat glands and hair follicles) was revealed.
authors.affiliation: Department of Biotechnology, Faculty of Biology, Moscow State University, Moscow, 119991, Russia. mmoisenovich@mail.ru.
authors.forename: M M
authors.initials: MM
authors.lastname: Moisenovich
authors.affiliation: Department of Biotechnology, Faculty of Biology, Moscow State University, Moscow, 119991, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Malyuchenko
authors.affiliation: Department of Biotechnology, Faculty of Biology, Moscow State University, Moscow, 119991, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Arkhipova
authors.affiliation: Department of Biotechnology, Faculty of Biology, Moscow State University, Moscow, 119991, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Goncharenko
authors.affiliation: Department of Biotechnology, Faculty of Biology, Moscow State University, Moscow, 119991, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Kotlyarova
authors.affiliation: State Research Institute for Genetics and Selection of Industrial Microorganisms, Pervyi Dorozhnyi proezd 1, Moscow, 117545, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Davydova
authors.affiliation: Department of Biotechnology, Faculty of Biology, Moscow State University, Moscow, 119991, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Vasil'eva
authors.affiliation: State Research Institute for Genetics and Selection of Industrial Microorganisms, Pervyi Dorozhnyi proezd 1, Moscow, 117545, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Bogush
authors.affiliation: Shumakov Research Institute of Transplantation and Artificial Organs, Russian Ministry of Health, ul. Shchukinskaya 1, Moscow, 113182, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Agapov
authors.affiliation: State Research Institute for Genetics and Selection of Industrial Microorganisms, Pervyi Dorozhnyi proezd 1, Moscow, 117545, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Debabov
authors.affiliation: Department of Biotechnology, Faculty of Biology, Moscow State University, Moscow, 119991, Russia.
authors.forename: M P
authors.initials: MP
authors.lastname: Kirpichnikov
mesh_terms: D000818:Animals; D005260:Female; D005349:Fibroins / Q000235:genetics / Q000494:pharmacology*; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D020100:Hydrogels; D011994:Recombinant Proteins; C086087:spidroin 1; D005349:Fibroins