title: Development and evaluation of solid dispersion of spironolactone using fusion method.
abstract: BACKGROUND
  Solubility and dissolution of a poor water-soluble drug are the two major barriers for formulation scientists in development of drug delivery. Many of the potent drugs do not show the therapeutic effects due to solubility issues but may show toxicity issues when used in high doses. Solid dispersion (SD) technology is an excellent tool for enhancing the solubility and dissolution and hence related bioavailability.
  
  
  METHODS
  SD of spironolactone (SPL) was developed using an inert carrier polyethylene glycol 4000 (PEG 4000) by the conventional fusion method and characterized for various characterization parameters.
  
  
  RESULTS
  Solubility of pure drug and SD of SPL in water was found to be 23.54 ± 1.75 μg/mL and 61.73 ± 1.26 μg/mL, respectively. The maximum cumulative percentage release from pure drug, SPL marketed product (tablet), physical mixture, and SPL SD at 60 min was 27.25 ± 1.83%, 35.64 ± 3.65%, 47.72 ± 2.45%, and 74.24 ± 3.25%, respectively in 0.1 N HCl.
  
  
  CONCLUSIONS
  SD of SPL was developed successfully. The solubility of SPL SD was found to be significantly increased (P < 0.05) as compared to SPL active pharmaceutical ingredient (API) and physical mixture of PEG 4000 and SPL. The current study indicated that SD of SPL was a better option for enhancing solubility of a poorly soluble therapeutic agent.
authors.affiliation: Department of Pharmacy, OPJS University, Rajasthan, India.
authors.lastname: Shamsuddin
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fazil
authors.affiliation: Department of Pharmacognosy, Jamia Hamdard, New Delhi, India.
authors.forename: Shahid Husain
authors.initials: SH
authors.lastname: Ansari
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
authors.forename: Javed
authors.initials: J
authors.lastname: Ali
keywords: Polyethylene glycol 4000 (PEG 4000); poor water solubility; solid dispersion (SD); spironolactone (SPL)