title: A Case Report of NK-Cell Lymphoproliferative Disease With a Wide Involvement of Digestive Tract Develop Into Epstein-Barr Virus Associated NK/T Cell Lymphoma in an Immunocompetent Patient.
abstract: Epstein-Barr virus (EBV) plays an important role in various diseases. EBV-associated lymphoproliferative disease (LPD) is a rare disease with a canceration tendency. It is difficult to differentiate LPD with involvement of digestive tract from Crohn disease due to similar clinical and endoscopic manifestations. We present a case report of multiple ulcers with esophagus, small bowel and the entire colon involved, proved to be NK-Cell LPD, developed into EBV-associated NK/T Cell lymphoma, in an immunocompetent man who was initially misdiagnosed as Crohn disease.This report underscores that intestinal ulcers should be cautiously diagnosed, for it sometimes could be a precancerous lesion.
authors.affiliation: From the Department of Gastroenterology (HC, YZ, QC), Department of Pathology (ZJ), Department of General Surgery (WZ), Sir Run Run Shaw Hospital, Zhejiang University School of Medicine (HC, YZ, ZJ, WZ, QC), and Inflammatory Bowel Disease Center of Sir Run Run Shaw Hospital (HC, YZ, ZJ, WZ, QC), Hangzhou, Zhejiang, China.
authors.forename: Haotian
authors.initials: H
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhinong
authors.initials: Z
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Qian
authors.initials: Q
authors.lastname: Cao
mesh_terms: D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007121:Immunocompetence; D007694:Killer Cells, Natural; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000821:virology*; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000175:diagnosis; D008297:Male