title: A new device for efficient preparation of standard antibiotic bead chains and customized antibiotic delivery.
abstract: Antibiotic-loaded polymethylmethacrylate (PMMA) beads are widely used in orthopedic practice for the prevention of infections after open fractures and in the management of osteomyelitis. The use of commercial beads is limited by insufficient flexibility, lack of provision for selection of specific antibiotic, and short drug-release time. Further, the manual procedure for the preparation of PMMA beads is slow, and the products are not uniform in size. Uniformity of the bead size is crucial because the placement of oversized beads place at sites with limited space (e.g., narrow medullary canal) is difficult, and their retrieval from such sites is painful to the patient. To overcome the limitations of commercial beads and manually prepared beads, we developed a simple device for the efficient preparation of antibiotic-loaded PMMA beads of uniform sizes. We describe the device, bead preparation, and the characteristics of the beads prepared using our device, and the preliminary clinical results. The beads obtained using this device were relatively small, had excellent flexibility, and were suitable for implantation in small spaces. The device permits the selection of the antibiotic to be loaded on to the beads. The results of preliminary studies of the beads prepared using our device have been positive, highlighting the need for more large-scale and longitudinal investigations.
authors.forename: Baochang
authors.initials: B
authors.lastname: Qi
authors.forename: Weina
authors.initials: W
authors.lastname: Ju
authors.forename: Tiecheng
authors.initials: T
authors.lastname: Yu
authors.forename: Tiejun
authors.initials: T
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Dahui
authors.initials: D
authors.lastname: Sun
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001843:Bone Cements / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005079:Excipients; D010316:Particle Size; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D014031:Tobramycin / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005079:Excipients; D019904:Polymethyl Methacrylate; D014031:Tobramycin