title: Altered intrinsic connectivity of the auditory cortex in congenital amusia.
abstract: Congenital amusia, a neurodevelopmental disorder of music perception and production, has been associated with abnormal anatomical and functional connectivity in a right frontotemporal pathway. To investigate whether spontaneous connectivity in brain networks involving the auditory cortex is altered in the amusic brain, we ran a seed-based connectivity analysis, contrasting at-rest functional MRI data of amusic and matched control participants. Our results reveal reduced frontotemporal connectivity in amusia during resting state, as well as an overconnectivity between the auditory cortex and the default mode network (DMN). The findings suggest that the auditory cortex is intrinsically more engaged toward internal processes and less available to external stimuli in amusics compared with controls. Beyond amusia, our findings provide new evidence for the link between cognitive deficits in pathology and abnormalities in the connectivity between sensory areas and the DMN at rest.
authors.affiliation: Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France; University Lyon 1, Lyon, France; yohana.leveque@inserm.fr.
authors.forename: Yohana
authors.initials: Y
authors.lastname: Leveque
authors.affiliation: INSERM U1077, Caen, France; and Université de Caen Basse-Normandie, UMR-S1077, Caen, France.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Fauvel
authors.affiliation: INSERM U1077, Caen, France; and Université de Caen Basse-Normandie, UMR-S1077, Caen, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Groussard
authors.affiliation: Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France; University Lyon 1, Lyon, France;
authors.forename: Anne
authors.initials: A
authors.lastname: Caclin
authors.affiliation: Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France; University Lyon 1, Lyon, France;
authors.forename: Philippe
authors.initials: P
authors.lastname: Albouy
authors.affiliation: INSERM U1077, Caen, France; and Université de Caen Basse-Normandie, UMR-S1077, Caen, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Platel
authors.affiliation: Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France; University Lyon 1, Lyon, France;
authors.forename: Barbara
authors.initials: B
authors.lastname: Tillmann
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001308:Auditory Perceptual Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D012146:Rest
keywords: default mode network; fMRI; frontotemporal network; functional connectivity; tone deafness