title: Evaluation of surgery risk factor associated to antithrombotic therapy in patients who underwent colorectal surgery.
abstract: BACKGROUND
  Use of antiplatelet therapy in western people is common. The risk of bleeding related to surgical procedure or invasive procedure is higher.We want to analyse the correlation between colorectal surgery, antiplatelet therapy and postoperative surgical complications.
  
  
  METHODS
  We categorized: 176 cases treated for colorectal cancer and we recorded the following data: type of surgery, body max index (BMI), haemoglobin value (Hb); preoperative prothrombin time (PT) and blood transfusions pre and postoperative and during surgery. The analysis focused on two groups: patients who received antiplatelet therapy (AT - antiplatelet therapy) and patients who didn't receive this therapy (NAT - not antiplatelet therapy).
  
  
  RESULTS
  In the group of patients who underwent right emicolectomy, haemoglobin values were lower in patients who received antithrombotic therapy than in patients who didn't receive this therapy with a statistical significance (p < 0,05); the same datum resulted in patients who underwent left emicolectomy. Normal weight patients that received antiplatelet therapy had lower values of haemoglobin without statistical significance (p value not significant). Overweight patients who underwent therapy with antiplatelet agents had lesser Hb value than group that didn't performed this therapy (p < 0,05). Patients who received AT showed a bigger percentage of blood transfusions regardless of type of surgery than the second group with statistical significance Normal weight patients showed a different incidence of blood transfusions between patients who underwent antiplatelet therapy (50%) and patients who didn't receive this therapy (29%) with statistic significance (p < 0,05). Overweight patients didn't present this significant difference. We analyzed the incidence of post-operative complications in normal weight patients and overweight patients and we showed that the incidence of complications, both minor and major, was higher in patients who underwent antiplatelet therapy than in the second group regardless of weight
  
  
  CONCLUSIONS
  Antiplatelet therapy in patients who underwent invasive surgery changes the incidence of some risk factors, such as bleeding, and of post-operative complications. This result underlines the importance of careful handling and preparation in patients receiving antithrombotic agents that have to undergo invasive surgery.
  
  
  BACKGROUND
  Antithrombotic therapy, Bleeding, Colorectal Surgery, Risk factor.
authors.forename: Paolo
authors.initials: P
authors.lastname: Del Rio
authors.forename: Francesco
authors.initials: F
authors.lastname: Sozzi
authors.forename: Elisa
authors.initials: E
authors.lastname: Bertocchi
authors.forename: Paolo
authors.initials: P
authors.lastname: Dell'Abate
authors.forename: Gennaro
authors.initials: G
authors.lastname: Perrone
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Arcuri
authors.forename: Mario
authors.initials: M
authors.lastname: Sianesi
mesh_terms: D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D015992:Body Mass Index; D003082:Colectomy / Q000379:methods; D015179:Colorectal Neoplasms / Q000601:surgery; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007430:Intraoperative Care; D050177:Overweight / Q000150:complications; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D019106:Postoperative Hemorrhage / Q000139:chemically induced* / Q000209:etiology; D011517:Prothrombin Time; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005343:Fibrinolytic Agents; D006454:Hemoglobins; D010975:Platelet Aggregation Inhibitors