title: Bioprospecting of Marine Macrophytes Using MS-Based Lipidomics as a New Approach.
abstract: The marine environment supports a remarkable diversity of organisms which are a potential source of natural products with biological activities. These organisms include a wide variety of marine plants (from micro- to macrophytes), which have been used in the food and pharmaceutical industry. However, the biochemistry and biological activities of many of these macrophytes (namely macroalgae and halophytes, including seagrasses) are still far from being fully explored. Most popular bioactive components include polysaccharides, peptides, phenolics and fatty acids (FAs). Polar lipids (glycolipids, phospholipids and betaine lipids) are emerging as novel value-added bioactive phytochemicals, rich in n-3 FA, with high nutritional value and health beneficial effects for the prevention of chronic diseases. Polar lipids account various combinations of polar groups, fatty acyl chains and backbone structures. The polar lipidome of macrophytes is remarkably diverse, and its screening represents a significant analytical challenge. Modern research platforms, particularly mass spectrometry (MS)-based lipidomic approaches, have been recently used to address this challenge and are here reviewed. The application of lipidomics to address lipid composition of marine macrophytes will contribute to the stimulation of further research on this group and foster the exploration of novel applications.
authors.affiliation: Mass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. elisabete.maciel@ua.pt.|Department of Biology &amp; CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. elisabete.maciel@ua.pt.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Maciel
authors.affiliation: Department of Fish Ecology and Evolution, Centre for Ecology, Evolution and Biogeochemistry, EAWAG Swiss Federal Institute of Aquatic Science and Technology, Seestrasse 79, CH-6047 Kastanienbaum, Switzerland. miguelcleal@gmail.com.
authors.forename: Miguel
authors.initials: M
authors.lastname: Costa Leal
authors.affiliation: Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. lillebo@ua.pt.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Lillebø
authors.affiliation: Mass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. p.domingues@ua.pt.
authors.forename: Pedro
authors.initials: P
authors.lastname: Domingues
authors.affiliation: Mass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. mrd@ua.pt.
authors.forename: Maria Rosário
authors.initials: MR
authors.lastname: Domingues
authors.affiliation: Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. rjcalado@hotmail.com.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Calado
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry*; D065132:Bioprospecting / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods; D055051:Salt-Tolerant Plants / Q000737:chemistry; D012624:Seaweed / Q000737:chemistry
chemical_list: D001688:Biological Products; D008055:Lipids
keywords: LC-MS; glycolipids; halophytes; lipidome; macroalgae; mass spectrometry; phospholipids; seagrasses