title: Changes in Differentiation of Thymic T Cells in the Progeny of Female Mice Subjected to Immune System Stimulation during Early Pregnancy.
abstract: Differentiation of T cells was studied in the progeny of female C57Bl/6 mice subjected to immunostimulation by administration of concanavalin A or adoptive transfer of concanavalin A-activated splenocytes. Acceleration of T cell maturation during the prepubertal period and decelerated differentiation during the pubertal and post-pubertal periods were revealed.
authors.affiliation: Research Institute of Human Morphology, Moscow, Russia. yaglova@mail.ru.
authors.forename: N V
authors.initials: NV
authors.lastname: Yaglova
authors.affiliation: Research Institute of Human Morphology, Moscow, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Obernikhin
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D049109:Cell Proliferation; D003208:Concanavalin A / Q000276:immunology*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D013154:Spleen / Q000166:cytology* / Q000637:transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology* / Q000276:immunology; D060168:Thymocytes / Q000166:cytology*
chemical_list: D003208:Concanavalin A
keywords: T cells; concanavalin A; differentiation; prenatal exposure; thymus