title: Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer.
abstract: Pleckstrin homology-like domain, family A, member 1 (PHLDA1) encodes a member of an evolutionarily conserved pleckstrin homology-related domain protein family. It was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomas. The exact molecular and biological functions ofPHLDA1remain to be elucidated. However, its expression is induced by a variety of external stimuli and there is evidence that it may function as a transcriptional activator that acts as a mediator of apoptosis, proliferation, differentiation and cell migration dependent on the cellular type and context. Recently, PHLDA1 has received attention due to its association with cancer. In the present review, the current knowledge of PHLDA1 protein structure, expression regulation and function is summarized. In addition, the current data in the literature is reviewed with regards to the role of PHLDA1 in cancer pathogenesis.
authors.affiliation: Discipline of Oncology, Department of Radiology, Faculty of Medicine, University of São Paulo, Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of São Paulo, São Paulo, SP 01246-000, Brazil.
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Nagai
keywords: PHLDA1; cancer; downregulation; oncogene; pleckstrin homology-like; stem cell; tumor suppressor gene