title: Chemokine regulation of neutrophil function in tumors.
abstract: The role of neutrophils in cancer and metastasis is still debated and controversial since they have been shown to be endowed with both pro- and antitumor functions. These contradictory results seem to be now explained by recent discoveries of tumor-associated neutrophils plasticity and multiple neutrophil subsets. Chemokines and chemokine receptors are known to tightly regulate the release of neutrophils from the bone marrow, their passage into circulation and transmigration into the tissues as well as tumor infiltration. It is emerging that chemokine receptors are differentially expressed by neutrophil subsets and they affect not only their recruitment but also their effector functions. Here we are resuming human and murine data suggesting that therapeutic modulation of neutrophil activity through the targeting of specific chemokines or chemokine receptors can improve their anti-tumoral properties.
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
authors.forename: Ornella
authors.initials: O
authors.lastname: Bonavita
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Massara
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Italy. Electronic address: raffaella.bonecchi@humanitasresearch.it.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
mesh_terms: D000818:Animals; D000066670:Cell Plasticity; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology
chemical_list: D018925:Chemokines
keywords: Cancer; Chemokines; Inflammation; Neutrophils