title: The preventive effect of fish oil on abdominal aortic aneurysm development.
abstract: Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta and high rupture-related mortality rates. AAA is histologically characterized by oxidative stress, chronic inflammation, and extracellular matrix degradation in the vascular wall. We previously demonstrated that aortic hypoperfusion could cause the vascular inflammation and AAA formation. However, the preventive method for hypoperfusion-induced AAA remains unknown. In this study, we evaluated the effect of fish oil on AAA development using a hypoperfusion-induced AAA animal model. Dilation of the abdominal aorta in the fish oil administration group was smaller than in the control group. Collagen destruction and oxidative stress were suppressed in the fish oil administration group than in the control group. These results suggested that fish oil could prevent the development of AAA induced by hypoperfusion.
authors.affiliation: a Department of Applied Biological Chemistry , Graduate School of Agriculture, Kinki University , Nara , Japan.
authors.forename: Hirona
authors.initials: H
authors.lastname: Kugo
authors.affiliation: a Department of Applied Biological Chemistry , Graduate School of Agriculture, Kinki University , Nara , Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Zaima
authors.affiliation: a Department of Applied Biological Chemistry , Graduate School of Agriculture, Kinki University , Nara , Japan.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Mouri
authors.affiliation: b Department of Medical Physiology , Hamamatsu University School of Medicine , Hamamatsu , Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: c Human Life Science R&D Center , Nippon Suisan Kaisha, Ltd. , Tokyo , Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yanagimoto
authors.affiliation: b Department of Medical Physiology , Hamamatsu University School of Medicine , Hamamatsu , Japan.
authors.forename: Tetsumei
authors.initials: T
authors.lastname: Urano
authors.affiliation: d Division of Vascular Surgery, Second Department of Surgery , Hamamatsu University School of Medicine , Hamamatsu , Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Unno
authors.affiliation: a Department of Applied Biological Chemistry , Graduate School of Agriculture, Kinki University , Nara , Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Moriyama
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D003094:Collagen / Q000378:metabolism; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005395:Fish Oils / Q000008:administration & dosage*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010477:Perfusion / Q000009:adverse effects; D059748:Proteolysis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014304:Triolein / Q000008:administration & dosage
chemical_list: D005395:Fish Oils; D014304:Triolein; D003094:Collagen
keywords: EPA; MMP2; MMP9; abdominal aortic aneurysm; fish oil