title: The challenge of predicting problematic chemicals using a decision analysis tool: Triclosan as a case study.
abstract: Manufacturers lack a reliable means for determining whether a chemical will be targeted for deselection from their supply chain. In this analysis, 3 methods for determining whether a specific chemical (triclosan) would meet the criteria necessary for being targeted for deselection are presented. The methods included a list-based approach, use of a commercially available chemical assessment software tool run in 2 modes, and a public interest evaluation. Our results indicated that triclosan was included on only 6 of the lists reviewed, none of which were particularly influential in chemical selection decisions. The results from the chemical assessment tool evaluations indicated that human and ecological toxicity for triclosan is low and received scores indicating that the chemical would be considered of low concern. However, triclosan's peak public interest tracked several years in advance of increased regulatory scrutiny of this chemical suggesting that public pressure may have been influential in deselection decisions. Key data gaps and toxicity endpoints not yet regulated such as endocrine disruption potential or phototoxicity, but that are important to estimate the trajectory for deselection of a chemical, are discussed. Integr Environ Assess Manag 2017;13:198-207. © 2016 SETAC.
authors.affiliation: Cardno ChemRisk LLC, San Francisco, California, USA.
authors.forename: Angela L
authors.initials: AL
authors.lastname: Perez
authors.affiliation: Cardno ChemRisk LLC, San Francisco, California, USA.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Gauthier
authors.affiliation: Cardno ChemRisk LLC, Boulder, Colorado, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Ferracini
authors.affiliation: Cardno ChemRisk LLC, Aliso Viejo, California, USA.
authors.forename: Dallas M
authors.initials: DM
authors.lastname: Cowan
authors.affiliation: TKingsbury LLC, San Ramon, California, USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Kingsbury
authors.affiliation: Cardno ChemRisk LLC, Pittsburgh, Pennsylvania, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Panko
mesh_terms: D003661:Decision Support Techniques; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000633:toxicity*; D004787:Environmental Pollution / Q000706:statistics & numerical data*; D018570:Risk Assessment / Q000379:methods; D014260:Triclosan / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D014260:Triclosan
keywords: Chemical Selection; Chemical analysis; Greener chemicals; Triclosan; “Safer” products