title: Probable Interspecies Transfer of the bla(VIM-4) Gene between Enterobacter cloacae and Klebsiella pneumoniae in a Single Infant Patient.
abstract: We report the interspecies transfer of the bla(VLM-4) gene in MBL-producing Enterobacter cloacae and Klebsiella pneumoniae isolates from a newborn patient who had received meropenem therapy. We show evidence that gene bla(VIM-4) was transmitted as a part of the class-1 integron on a ca. -90 kb conjugative plasmid. High homology of nucleotide sequence was observed between the integron found in VIM-4 producing E. cloacae and K. pneumoniae strains tested and class-1 integrons previously reporteded in Pseudomonas aeruginosa from Hungary and Poland. This finding may suggest P. aeruginosa as a potential source of acquired VIM-4 in Enterobacteriaceae.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Piekarska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zacharczuk
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rzeczkowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wołkowicz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Januszkiewicz
authors.forename: Edyta
authors.initials: E
authors.lastname: Podsiadły
authors.forename: Urszula
authors.initials: U
authors.lastname: Demkow
authors.forename: Rafał
authors.initials: R
authors.lastname: Gierczyński
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016972:Enterobacter cloacae / Q000235:genetics* / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D022761:Gene Transfer, Horizontal; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007711:Klebsiella pneumoniae / Q000235:genetics* / Q000502:physiology; D008297:Male; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases