title: Altered regional homogeneity in epileptic patients with infantile spasm: A resting-state fMRI study.
abstract: Infantile spasm (IS) syndrome is an age-related epileptic encephalopathy that occurs in children. The purpose of this study was to investigate regional homogeneity (ReHo) changes in IS patients. Resting-state fMRI was performed on 11 patients with IS, along with 35 age- and sex-matched healthy subjects. Group comparisons between the two groups demonstrate that the pattern of regional synchronization synchronization in IS patients is changed. Decreased ReHo values were found in default mode network, bilateral motor-related areas and left occipital gyrus of the patient group. Increased ReHo was found in regions of cingulum, cerebellum, supplementary motor area and brain deep nucleus, such as hippocampus, caudate, thalamus and insula. The significant differences might indicate that epileptic action have some injurious effects on the motor, executive and cognitive related regions. In addition, ReHo values of left precuneus and right superior frontal gyrus were associated with the epilepsy duration in the IS group. The correlation results indicate that the involvement of these regions may be related to the seizure generation. Our results suggest that IS may have an injurious effect on the brain activation. The findings may shed new light on the understanding the neural mechanism of IS epilepsy.
authors.affiliation: Department of Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Tan
authors.affiliation: The Institute of Clinical Anatomy, Southern Medical University, Guangzhou, China.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shenzhen Children Hospital, Shenzhen, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Zang
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Heye
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Shenzhen Children Hospital, Shenzhen, China.
authors.forename: Cailei
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Neurology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Shenzhen Children Hospital, Shenzhen, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Shenzhen Children Hospital, Shenzhen, China.
authors.forename: Dezhi
authors.initials: D
authors.lastname: Cao
authors.affiliation: Shenzhen Children Hospital, Shenzhen, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Shenzhen Children Hospital, Shenzhen, China.
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Liao
authors.affiliation: Shenzhen Children Hospital, Shenzhen, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.|Beijing Key Laboratory in Epilepsy, Beijing, China.|Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Guoming
authors.initials: G
authors.lastname: Luan
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013036:Spasms, Infantile / Q000000981:diagnostic imaging* / Q000503:physiopathology
keywords: DMN; Epilepsy; infantile spasm; regional homogeneity; resting-state fMRI; thalamus