title: Effect of Repeated 1-h Episodes of Immobilization Stress on Activity of Glucocorticoid Metabolism Enzymes in the Liver.
abstract: Differences in corticosterone level associated with different activity of glucocorticoid-oxidizing enzymes in the liver were revealed in rats exposed to stress. Pro-inflammatory changes in the liver were associated with enhanced CYP3A-dependent monooxygenation.
authors.affiliation: South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia. vadimed@yandex.ru.
authors.forename: V E
authors.initials: VE
authors.lastname: Tseilikman
authors.affiliation: South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Kozochkin
authors.affiliation: South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Sinitskii
authors.affiliation: South-Ural State University (National Research University), Chelyabinsk, Russia.
authors.forename: O B
authors.initials: OB
authors.lastname: Tseylikman
authors.affiliation: South-Ural State University (National Research University), Chelyabinsk, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Lapshin
authors.affiliation: South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Kuzina
authors.affiliation: South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Komel'kova
authors.affiliation: South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Telesheva
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism*; D005938:Glucocorticoids / Q000378:metabolism*; D007103:Immobilization; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology* / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D015850:Interleukin-6; D051544:Cytochrome P-450 CYP3A; D003345:Corticosterone
keywords: 11β-hydroxysteroid dehydrogenase-2, CYP3A; corticosterone; stress