title: Targeting and therapeutic peptides in nanomedicine for atherosclerosis.
abstract: Peptides in atherosclerosis nanomedicine provide structural, targeting, and therapeutic functionality and can assist in overcoming delivery barriers of traditional pharmaceuticals. Moreover, their inherent biocompatibility and biodegradability make them especially attractive as materials intended for use in vivo In this review, an overview of nanoparticle-associated targeting and therapeutic peptides for atherosclerosis is provided, including peptides designed for cellular targets such as endothelial cells, monocytes, and macrophages as well as for plaque components such as collagen and fibrin. An emphasis is placed on recent advances in multimodal strategies and a discussion on current challenges and barriers for clinical applicability is presented.
authors.affiliation: University of Southern California, Los Angeles 90089-1111, CA, USA eunchung@usc.edu.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Chung
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy; D016503:Drug Delivery Systems; D004730:Endothelium, Vascular / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D058990:Molecular Targeted Therapy / Q000379:methods; D009000:Monocytes / Q000187:drug effects; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010455:Peptides
keywords: Peptides; atherosclerosis; biomaterial; inflammation; micelles; nanoparticles