title: Fluid phase recognition molecules in neutrophil-dependent immune responses.
abstract: The innate immune system comprises both a cellular and a humoral arm. Neutrophils are key effector cells of the immune and inflammatory responses and have emerged as a major source of humoral pattern recognition molecules (PRMs). These molecules, which include collectins, ficolins, and pentraxins, are specialised in the discrimination of self versus non-self and modified-self and share basic multifunctional properties including recognition and opsonisation of pathogens and apoptotic cells, activation and regulation of the complement cascade and tuning of inflammation. Neutrophils act as a reservoir of ready-made soluble PRMs, such as the long pentraxin PTX3, the peptidoglycan recognition protein PGRP-S, properdin and M-ficolin, which are stored in neutrophil granules and are involved in neutrophil effector functions. In addition, other soluble PRMs, such as members of the collectin family, are not expressed in neutrophils but can modulate neutrophil-dependent immune responses. Therefore, soluble PRMs are an essential part of the innate immune response and retain antibody-like effector functions. Here, we will review the expression and general function of soluble PRMs, focusing our attention on molecules involved in neutrophil effector functions.
authors.affiliation: Department of Immunology and Inflammation, Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, 20089 Rozzano, Milan, Italy. Electronic address: sebastien.jaillon@humanitasresearch.it.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Jaillon
authors.affiliation: Department of Immunology and Inflammation, Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ponzetta
authors.affiliation: Department of Immunology and Inflammation, Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Magrini
authors.affiliation: Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, 20089 Rozzano, Milan, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Barajon
authors.affiliation: Department of Immunology and Inflammation, Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Milan, Italy.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Barbagallo
authors.affiliation: Department of Immunology and Inflammation, Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, 20089 Rozzano, Milan, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
authors.affiliation: Department of Immunology and Inflammation, Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, 20089 Rozzano, Milan, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
mesh_terms: D000818:Animals; D015415:Biomarkers; D005786:Gene Expression Regulation; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate; D008024:Ligands; D018375:Neutrophil Activation / Q000235:genetics / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D011485:Protein Binding; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D008024:Ligands; D051192:Receptors, Pattern Recognition
keywords: Ficolin; Innate immunity; Neutrophil; Pattern-recognition molecule; Pentraxin