title: Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab.
abstract: Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies.
authors.affiliation: Department of Medicine, Division of Infectious Diseases.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Gundacker
authors.affiliation: Department of Medicine, Division of Infectious Diseases.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Jordan
authors.affiliation: Departments of Neurology.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Jones
authors.affiliation: Pathology , University of Alabama at Birmingham.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Drwiega
authors.affiliation: Department of Medicine, Division of Infectious Diseases.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Pappas
keywords: Cryptococcus; IRIS; fungal; meningitis; natalizumab