title: Effect of hyaluronic acid in bone formation and its applications in dentistry.
abstract: Hyaluronic acid (HA), the simplest glycosaminoglycan, participates in several important biological procedures, including mediation of cellular signaling, regulation of cell adhesion and proliferation, and manipulation of cell differentiation. The effect of HA on cell proliferation and differentiation depends on its molecular weight (MW) and concentration. Moreover, the properties of high viscosity, elasticity, highly negative charge, biocompatibility, biodegradability, and nonimmunogenicity make HA attractive in tissue engineering and disease treatment. This review comprises an overview of the effect of HA on cell proliferation and differentiation in vitro, the role of HA in bone regeneration in vivo, and the clinical applications of HA in dentistry, focusing on the mechanism underlining the effect of MW and concentration of HA on cell proliferation and osteogenic differentiation. It is expected that practical progress of HA both in laboratory-based experiments and clinical applications will be achieved in the next few years. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1560-1569, 2016.
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Implants, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors.forename: Ningbo
authors.initials: N
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Implants, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Implants, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Qin
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Implants, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhai
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Implants, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Implants, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Implants, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors.forename: Dehua
authors.initials: D
authors.lastname: Li
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002986:Clinical Trials as Topic; D003813:Dentistry / Q000379:methods*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects*
chemical_list: D006820:Hyaluronic Acid
keywords: bone; dentistry; differentiation; hyaluronic acid; proliferation