title: Diterpenes: Advances in Neurobiological Drug Research.
abstract: A significant number of studies have been performed with diterpene effect on the brain. Our study aims to make a systematic revision on them. The initial purpose of this review was to screen diterpenes with neurological activity, in particular those that have already been studied and published in different journals (databases until August 2015). The second purpose was to make an action-wise discussion as results viewed on them by taking into drug discovery and development account. Diterpenes considered in this review were selected on the basis of updated information on them and having sufficient information on their screenings. We identified several examples of diterpenes having an interest in further study. We have included the possible sources of them as observed in evidence, their known molecular neurobiological mechanisms, and the active constituents responsible for such activities with the doses and test systems. Results suggest diterpenes to have neurobiological activities like neuro-protection, anti-epileptic, anxiolytic, anti-Alzheimer's disease, anti-Parkinson's disease, anti-cerebral ischemia, anti-neuropathic pain, anti-neuro-inflammatory, and many more. In conclusion, diterpenes may be the prominent candidates in neurobiological drug research. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Northest Biotechnology Network (RENORBIO), Post-graduation Program in Biotechnology, Federal University of Piauí, 64.049-550, Teresina, Brazil.|Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550, Teresina, Brazil.|Department of Pharmacy, Southern University Bangladesh, 22-Shahid Mirza Lane (E), Academic building-II, 1st floor, 739/A, Mehedibag Road, Mehedibag-4000, Chittagong, Bangladesh.
authors.forename: Md Torequl
authors.initials: MT
authors.lastname: Islam
authors.affiliation: Northest Biotechnology Network (RENORBIO), Post-graduation Program in Biotechnology, Federal University of Piauí, 64.049-550, Teresina, Brazil.
authors.forename: Claucenira Bandeira
authors.initials: CB
authors.lastname: da Silva
authors.affiliation: Northest Biotechnology Network (RENORBIO), Post-graduation Program in Biotechnology, Federal University of Piauí, 64.049-550, Teresina, Brazil.|Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550, Teresina, Brazil.
authors.forename: Marcus Vinícius Oliveira Barros
authors.initials: MV
authors.lastname: de Alencar
authors.affiliation: Northest Biotechnology Network (RENORBIO), Post-graduation Program in Biotechnology, Federal University of Piauí, 64.049-550, Teresina, Brazil.|Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550, Teresina, Brazil.
authors.forename: Márcia Fernanda Correia Jardim
authors.initials: MF
authors.lastname: Paz
authors.affiliation: Northest Biotechnology Network (RENORBIO), Post-graduation Program in Biotechnology, Federal University of Piauí, 64.049-550, Teresina, Brazil.
authors.forename: Fernanda Regina de Castro
authors.initials: FR
authors.lastname: Almeida
authors.affiliation: Northest Biotechnology Network (RENORBIO), Post-graduation Program in Biotechnology, Federal University of Piauí, 64.049-550, Teresina, Brazil.|Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550, Teresina, Brazil.
authors.forename: Ana Amélia de Carvalho
authors.initials: AA
authors.lastname: Melo-Cavalcante
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D004224:Diterpenes / Q000627:therapeutic use*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy
chemical_list: D000927:Anticonvulsants; D004224:Diterpenes
keywords: diterpenes; essential oils; nervous system