title: A new anthraquinone and eight constituents from Hedyotis caudatifolia Merr. et Metcalf: isolation, purification and structural identification.
abstract: Hedyotis caudatifolia Merr. et Metcalf. (HC), a folk medicine in Yao nationalities areas in China, was used to investigate the chemical constituents. Through silica gel and Sephadex LH-20 column chromatography, nine compounds were isolated and purified. By physical and chemical properties, IR, MS (EI-MS, high resolution EI-MS), 1D NMR ((1)H NMR, (13)C NMR) and 2D NMR (HSQC, (1)H-(1)H COSY, HMBC), their structures were identified as β-sitosterol (1), stigmasterol (2), scopolin (3), 2-hydroxy-1,7,8-trimethoxyanthracene-9,10-dione (4), oleanolic acid (5), ursolic acid (6), methyl barbinervate (7), β-daucosterol (8) and p-Hydroxybenzoic acid (9). These compounds were isolated from HC for the first time, and 4 a new anthraquinone whose biological activities are worth to be investigated in future. These compounds may contribute to the HC's pharmacological effects on treating diseases, and may be used as candidates for control index in establishing the quality control standard of HC.
authors.affiliation: a Guangxi University of Chinese Medicine , Nanning , China.|b College of Chemistry and Chemical Engineering , Guangxi University , Nanning , China.
authors.forename: Peng
authors.initials: P
authors.lastname: Luo
authors.affiliation: a Guangxi University of Chinese Medicine , Nanning , China.
authors.forename: Jiale
authors.initials: J
authors.lastname: Su
authors.affiliation: a Guangxi University of Chinese Medicine , Nanning , China.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: a Guangxi University of Chinese Medicine , Nanning , China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wei
authors.affiliation: b College of Chemistry and Chemical Engineering , Guangxi University , Nanning , China.
authors.forename: Wanxing
authors.initials: W
authors.lastname: Wei
authors.affiliation: a Guangxi University of Chinese Medicine , Nanning , China.
authors.forename: Weigao
authors.initials: W
authors.lastname: Pan
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification*; D002681:China; D032064:Hedyotis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D012855:Sitosterols / Q000302:isolation & purification; D013265:Stigmasterol / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes / Q000302:isolation & purification; D000097245:Ursolic Acid
chemical_list: D000880:Anthraquinones; D009828:Oleanolic Acid; D012855:Sitosterols; D013265:Stigmasterol; D014315:Triterpenes; D000097245:Ursolic Acid; C025473:gamma-sitosterol; C011015:lyoniside
keywords: 2-hydroxy-1,7,8-trimethoxyanthracene -9,10-dione; Hedyotis caudatifolia Merr. et Metcalf; chemical constituents