title: Differences in cognitive ability and hippocampal volume between Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups, and their correlation.
abstract: The study investigated differences in cognitive ability and hippocampal volume between groups of patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), and healthy control (HC) subjects, and explored the relationship between cognitive ability and hippocampal volume. Among the sub-tests of Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), the Boston naming test score decreased in the order HC, aMCI, and AD. The hippocampal volumes of subjects with AD and aMCI were relatively smaller than those of HC individuals. There were strongly positive correlations between hippocampal volume and the scores for the Boston naming test. Discriminant analysis identified the Boston naming test as having the highest level of discrimination among the variables used to differentiate the three groups (89.9%). In conclusion, the Boston naming test accurately differentiated the three groups and was correlated with hippocampal volume. These results will be helpful for choosing an accurate and economically feasible test method that efficiently differentiates the three groups.
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Choi
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Gim
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Woo-Ram
authors.initials: WR
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Kyung-Ryul
authors.initials: KR
authors.lastname: Mun
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Gye-Rae
authors.initials: GR
authors.lastname: Tack
authors.affiliation: School of Energy Systems Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul, South Korea.
authors.forename: Bongsoo
authors.initials: B
authors.lastname: Lee
authors.affiliation: Department of Radiology, School of Medicine, Konkuk University, Chungju, South Korea.
authors.forename: Young Chil
authors.initials: YC
authors.lastname: Choi
authors.affiliation: Department of Obstetrics & Gynecology, Konkuk University, Chungju, South Korea.
authors.forename: Hyun-Jun
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Chungbuk National University Hospital, Cheongju, South Korea.
authors.forename: Seung Hwa
authors.initials: SH
authors.lastname: Hong
authors.affiliation: Department of Information & Communication Engineering, Dongguk University, Seoul, South Korea.
authors.forename: Dae-Woon
authors.initials: DW
authors.lastname: Lim
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea. Electronic address: scchung@kku.ac.kr.
authors.forename: Soon-Cheol
authors.initials: SC
authors.lastname: Chung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000523:psychology; D000647:Amnesia / Q000473:pathology* / Q000523:psychology; D016022:Case-Control Studies; D003071:Cognition; D060825:Cognitive Dysfunction / Q000473:pathology* / Q000523:psychology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D009929:Organ Size
keywords: Alzheimer disease; Amnestic mild cognitive impairment; Boston naming test; Cognitive ability; Hippocampal volume