title: A virtual sizing tool for mitral valve annuloplasty.
abstract: Functional mitral regurgitation, a backward leakage of the mitral valve, is a result of left ventricular growth and mitral annular dilatation. Its gold standard treatment is mitral annuloplasty, the surgical reduction in mitral annular area through the implantation of annuloplasty rings. Recurrent regurgitation rates may, however, be as high as 30% and more. While the degree of annular downsizing has been linked to improved long-term outcomes, too aggressive downsizing increases the risk of ring dehiscences and significantly impairs repair durability. Here, we prototype a virtual sizing tool to quantify changes in annular dimensions, surgically induced tissue strains, mitral annular stretches, and suture forces in response to mitral annuloplasty. We create a computational model of dilated cardiomyopathy onto which we virtually implant annuloplasty rings of different sizes. Our simulations confirm the common intuition that smaller rings are more invasive to the surrounding tissue, induce higher strains, and require larger suture forces than larger rings: The total suture force was 2.2 N for a 24-mm ring, 1.9 N for a 28-mm ring, and 0.8 N for a 32-mm ring. Our model predicts the highest risk of dehiscence in the septal and postero-lateral annulus where suture forces are maximal. These regions co-localize with regional peaks in myocardial strain and annular stretch. Our study illustrates the potential of realistic predictive simulations in cardiac surgery to identify areas at risk for dehiscence, guide the selection of ring size and shape, rationalize the design of smart annuloplasty rings and, ultimately, improve long-term outcomes after surgical mitral annuloplasty. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, 06511, CT, USA.
authors.forename: Manuel K
authors.initials: MK
authors.lastname: Rausch
authors.affiliation: Department of Mechanical Engineering, Stanford University, Stanford, 94305, CA, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Zöllner
authors.affiliation: Laboratoire de Mécanique des Solides CNRS-UMR 7649, Ecole Polytechnique, Palaiseau, 91128, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Genet
authors.affiliation: Dassault Systèmes Simulia Corporation, Fremont, 94538, CA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Baillargeon
authors.affiliation: University Heart Center Freiburg, Freiburg, 79106, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bothe
authors.affiliation: Departments of Mechanical Engineering, Bioengineering and Cardiothoracic Surgery, Stanford University, Stanford, 94305, CA, USA.
authors.forename: E
authors.initials: E
authors.lastname: Kuhl
mesh_terms: D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000473:pathology; D058386:Mitral Valve Annuloplasty / Q000295:instrumentation* / Q000379:methods*; D008944:Mitral Valve Insufficiency
keywords: annuoloplasty; finite element analysis; growth and remodeling; mitral regurgitation; mitral valve; strain