title: Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine.
abstract: In this review, we provide a description of those candidate biomarkers which have been demonstrated by multiple-omics approaches to vary in correlation with specific clinical manifestations of sickle cell severity. We believe that future clinical analyses of severity phenotype will require a multiomic analysis, or an omics stack approach, which includes integrated interactomics. It will also require the analysis of big data sets. These candidate biomarkers, whether they are individual or panels of functionally linked markers, will require future validation in large prospective and retrospective clinical studies. Once validated, the hope is that informative biomarkers will be used for the identification of individuals most likely to experience severe complications, and thereby be applied for the design of patient-specific therapeutic approaches and response to treatment. This would be the beginning of precision medicine for sickle cell disease.
authors.affiliation: Department of Pediatrics and Department of Physiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA sgoodma5@uthsc.edu.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Goodman
authors.affiliation: Department of Pediatrics, Augusta University, Augusta, GA 30912, USA.
authors.forename: Betty S
authors.initials: BS
authors.lastname: Pace
authors.affiliation: Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80202, USA.
authors.forename: Kirk C
authors.initials: KC
authors.lastname: Hansen
authors.affiliation: Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80202, USA.
authors.forename: Angelo
authors.initials: A
authors.lastname: D'alessandro
authors.affiliation: Biochemistry and Molecular Biology Department, University of Texas at Houston, TX 77030, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: University of Texas at Dallas, Richardson, TX 75080, USA.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Daescu
authors.affiliation: Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Glatt
mesh_terms: D000755:Anemia, Sickle Cell / Q000175:diagnosis* / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D005319:Fetal Hemoglobin / Q000032:analysis; D020869:Gene Expression Profiling; D005819:Genetic Markers; D006801:Humans; D055432:Metabolomics; D035683:MicroRNAs / Q000235:genetics; D057285:Precision Medicine / Q000379:methods*; D040901:Proteomics; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D035683:MicroRNAs; D005319:Fetal Hemoglobin
keywords: Genomics; interactomics; metabolomics; precision medicine; proteomics; sickle cell disease