title: Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles.
abstract: We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging. Co-encapsulation of NIR fluorescent dyes and subsequent photomodulation provides a NIR fluorescent tool to assess both particle location and successful photorelease.
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Carl-Johan
authors.initials: CJ
authors.lastname: Carling
authors.affiliation: Department of Chemistry and Biochemistry University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Olejniczak
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Foucault-Collet
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Collet
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Mathieu L
authors.initials: ML
authors.lastname: Viger
authors.affiliation: Department of Nanoengineering University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Viet Anh Nguyen
authors.initials: VA
authors.lastname: Huu
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Brendan M
authors.initials: BM
authors.lastname: Duggan
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA; Department of Nanoengineering University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA; Department of Materials Science and Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Adah
authors.initials: A
authors.lastname: Almutairi