title: Marine Natural Products from New Caledonia--A Review.
abstract: Marine micro- and macroorganisms are well known to produce metabolites with high biotechnological potential. Nearly 40 years of systematic prospecting all around the New Caledonia archipelago and several successive research programs have uncovered new chemical leads from benthic and planktonic organisms. After species identification, biological and/or pharmaceutical analyses are performed on marine organisms to assess their bioactivities. A total of 3582 genera, 1107 families and 9372 species have been surveyed and more than 350 novel molecular structures have been identified. Along with their bioactivities that hold promise for therapeutic applications, most of these molecules are also potentially useful for cosmetics and food biotechnology. This review highlights the tremendous marine diversity in New Caledonia, and offers an outline of the vast possibilities for natural products, especially in the interest of pursuing collaborative fundamental research programs and developing local biotechnology programs.
authors.affiliation: Laboratoire d'Excellence Labex-CORAIL, Institut de Recherche pour le Développement (IRD), UMR ENTROPIE (IRD-Université de La Réunion-CNRS), BP A5, Nouméa Cedex 98848, Nouvelle-Calédonie. sofia-elena.motuhi@ird.fr.|USR 3151 CNRS, Protein Phosphorylation &amp; Human Diseases, Station Biologique de Roscoff, Sorbonne Universities, UPMC Univ Paris 06, CS 90074, Roscoff Cedex F-29688, France. sofia-elena.motuhi@ird.fr.
authors.forename: Sofia-Eléna
authors.initials: SE
authors.lastname: Motuhi
authors.affiliation: UMR 7272 CNRS, Marine Natural Products Team, Nice Institute of Chemistry (ICN), University Nice Sophia Antipolis, Parc Valrose, Nice Cedex 02 F-06108, France. mohamed.mehiri@unice.fr.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mehiri
authors.affiliation: Laboratoire d'Excellence Labex-CORAIL, Institut de Recherche pour le Développement (IRD), UMR ENTROPIE (IRD-Université de La Réunion-CNRS), BP A5, Nouméa Cedex 98848, Nouvelle-Calédonie. claude.payri@ird.fr.
authors.forename: Claude Elisabeth
authors.initials: CE
authors.lastname: Payri
authors.affiliation: UMR 8227 CNRS, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, Roscoff Cedex F-29688, France. labarre@sb-roscoff.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: La Barre
authors.affiliation: USR 3151 CNRS, Protein Phosphorylation &amp; Human Diseases, Station Biologique de Roscoff, Sorbonne Universities, UPMC Univ Paris 06, CS 90074, Roscoff Cedex F-29688, France. bach@sb-roscoff.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bach
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000378:metabolism*; D044822:Biodiversity; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001709:Biotechnology / Q000379:methods; D003358:Cosmetics / Q000737:chemistry; D006801:Humans; D009510:New Caledonia
chemical_list: D001688:Biological Products; D003358:Cosmetics
keywords: New Caledonia; bioactive molecules pipeline; chemodiversity; coral reefs; marine biodiversity