title: A coupled chemo-fluidic computational model for thrombogenesis in infarcted left ventricles.
abstract: A coupled chemo-fluidic computational model for investigating flow-mediated thrombogenesis in infarcted left ventricles (LVs) is proposed. LV thrombus (LVT) formation after the acute myocardial infarction (AMI) may lead to thromboembolic events that are associated with high mortality and morbidity, and reliable stratification of LVT risk is the key to managing the treatment of AMI patients. There have been several studies emphasizing the importance of LV blood flow patterns on thrombus formation; however, given the complex interplay between ventricular flow dynamics and biochemistry of thrombogenesis, current understanding is mostly empirical. In the present model, blood flow in the LV is obtained by solving the incompressible Navier-Stokes equations, and this is coupled to the biochemical modeling of the coagulation cascade, platelet activation, and fibrinogen polymerization. The coupled model is used to examine the effect of ventricular flow patterns on thrombogenesis in modeled ventricles. It is expected that the method developed here will enable in-depth studies of thrombogenesis in patient-derived infarcted LV models.
authors.affiliation: Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland; and.
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Seo
authors.affiliation: School of Medicine, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Thura
authors.initials: T
authors.lastname: Abd
authors.affiliation: School of Medicine, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Richard T
authors.initials: RT
authors.lastname: George
authors.affiliation: Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland; and School of Medicine, Johns Hopkins University, Baltimore, Maryland mittal@jhu.edu.
authors.forename: Rajat
authors.initials: R
authors.lastname: Mittal
mesh_terms: D001777:Blood Coagulation; D001783:Blood Flow Velocity; D001792:Blood Platelets / Q000378:metabolism; D003198:Computer Simulation; D005340:Fibrinogen / Q000378:metabolism; D006322:Heart Aneurysm / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D015539:Platelet Activation; D012039:Regional Blood Flow; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D013927:Thrombosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D005340:Fibrinogen
keywords: biochemical reaction; blood clot; cardiac flow; coagulation cascade; computational hemodynamics; intraventricular flow