title: Mycobacterium conceptionense Bloodstream Infection in a Patient with Advanced Gastric Carcinoma.
abstract: A 65-year-old Japanese male farmer with advanced gastric adenocarcinoma and multiple hepatic metastases was admitted to our hospital. Blood culture results were positive on day 5, and Gram-positive rods were detected. According to the results of Ziehl-Neelsen staining and a cultured colony of this bacterium, we suspected a mycobacterial infection. Suspecting a rapidly growing mycobacterium (RGM), we started multidrug therapy with levofloxacin, clarithromycin, and ethambutol, and the patient recovered from the bloodstream infection. Further gene examination (16S rRNA, hsp65, and sodA) revealed an isolate of Mycobacterium conceptionense. M. conceptionense was first identified as an RGM in 2006. Among previous case reports of M. conceptionense infections, bone and soft tissue infections in hosts with a disorder of the normal structure (e.g., surgical sites) were dominant. We report the characteristics of M. conceptionense infection in this first Japanese case report and a review of the literature.
authors.affiliation: Department of Infection Control and Prevention, Kurume University School of Medicine.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yaita
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Matsunaga
authors.forename: Naotaka
authors.initials: N
authors.lastname: Tashiro
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Sakai
authors.forename: Kenji
authors.initials: K
authors.lastname: Masunaga
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Koichi
authors.initials: K
authors.lastname: Oshima
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Chikamatsu
authors.forename: Akiko
authors.initials: A
authors.lastname: Takaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mitarai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D044466:Asian People; D001426:Bacterial Proteins / Q000235:genetics; D002277:Carcinoma / Q000150:complications*; D018834:Chaperonin 60 / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008828:Microbiological Techniques; D008853:Microscopy; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D011860:Radiography, Abdominal; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D017422:Sequence Analysis, DNA; D013154:Spleen / Q000000981:diagnostic imaging; D013194:Staining and Labeling; D013274:Stomach Neoplasms / Q000150:complications*; D013482:Superoxide Dismutase / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018834:Chaperonin 60; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S; C074119:heat-shock protein 65, Mycobacterium; C095500:SodA protein, Bacteria; D013482:Superoxide Dismutase