title: Pressure algometry and enzyme-linked immunosorbent assay of natural antibodies in the evaluation of pain syndrome.
abstract: The dynamics of possible markers of pain syndrome: pain pressure thresholds of intolerance (PTI) and natural antibodies to mediators of pain processing (nAbs) in blood serum at dorsalgia was studied. We have shown that most men and women had reduced PTIs. Night PTIs were lower than daytime PTIs regardless of the gender. The study of the content of nAbs to opioids and biogenic amines by ELISA have shown a prolonged maintenance of their elevated and high levels that could evoke long-term effect in pain chronization. Thus, the pressure algometry and ELISA of nAbs to pain processing mediators make it possible to assess the individual pain status objectively and, on this bases, to propose personal schemes of treatment.
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia. annalevashova3@gmail.com.
authors.forename: A I
authors.initials: AI
authors.lastname: Levashova
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Artiushkova
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Morozova
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Petrochenko
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Myagkova
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Moseikin
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia.
authors.forename: L F
authors.initials: LF
authors.lastname: Panchenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods*; D017288:Pain Threshold; D011312:Pressure; D012585:Sciatica / Q000097:blood / Q000175:diagnosis*; D014110:Touch
chemical_list: D000906:Antibodies; D015415:Biomarkers