title: [Can we prevent preeclampsia?].
abstract: Preeclampsia (PE), a specific complication of pregnancy, is one of the most frequent causes of maternal and fetal morbidity and mortality in the world. Recently, PE risk calculation algorithms allowing early detection of PE in the first trimester of pregnancy have been described. The aim of early detection would be to rapidly introduce an effective preventive treatment. The aim of our work is to study the different preventive treatments through the literature. Aspirin has some efficiency and reduces the risk of PE from 10 to 24%. It is most effective when the dose exceeds 75mg and when introduced before 16 gestational age. Early introduction of aspirin mainly prevents severe and preterm PE. Low molecular weight heparin (LMWH) and vitamin D appear to be promising therapy for PE but further research is required. Calcium administered at 1g/day reduces the risk of PE especially to patients with low baseline calcium intake. A low dose of calcium could also reduce the risk of PE but this must be confirmed. Other preventive measures (antioxidants, nitric oxide, progesterone, rest, exercise) do not reduce the incidence of PE.
authors.affiliation: CHRU de Lille, clinique d'obstétrique, maternité Jeanne-de-Flandre, pôle femme-mère-nouveau-né, avenue Eugène-Avinée, 59037 Lille cedex, France. Electronic address: louise.ghesquiere@etu.univ-lille2.fr.
authors.forename: Louise
authors.initials: L
authors.lastname: Ghesquière
authors.affiliation: CHRU de Lille, clinique d'obstétrique, maternité Jeanne-de-Flandre, pôle femme-mère-nouveau-né, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Clouqueur
authors.affiliation: CHRU de Lille, clinique d'obstétrique, maternité Jeanne-de-Flandre, pôle femme-mère-nouveau-né, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Garabedian
authors.affiliation: AP-HP, hôpital Cochin, université Paris Descartes, service de maternité Port-Royal, 123, boulevard du Port-Royal, 75014 Paris, France; Fondation PremUP, 75014 Paris, France.
authors.forename: Vassili
authors.initials: V
authors.lastname: Tsatsaris
authors.affiliation: CHRU de Lille, clinique d'obstétrique, maternité Jeanne-de-Flandre, pôle femme-mère-nouveau-né, avenue Eugène-Avinée, 59037 Lille cedex, France; Université Lille 2-Nord de France, faculté de médecine Henri-Warembourg, 59000 Lille, France.
authors.forename: Veronique
authors.initials: V
authors.lastname: Houfflin-Debarge
mesh_terms: D000925:Anticoagulants; D005260:Female; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors