title: [Application of paramunity inducers in small animal practice].
abstract: Paramunity inducers have been used to treat small animals for decades. Paramunity inducers are based on attenuated and inactivated poxviruses (avipox virus and parapox virus). Their applications include both therapeutic and prophylactic use in various diseases. Despite their wide and variable use, only a very small number of placebo-controlled studies has been published. Positive effects in preventing kitten mortality and in treating feline stomatitis have been reported, however, no statistically significant effect of their therapeutic use in canine parvovirus infection, feline leukemia infection virus infection or canine papillomavirus infection could be demonstrated. For these infectious diseases, paramunity inducers do not appear to be effective.
authors.forename: A L
authors.initials: AL
authors.lastname: Proksch
authors.affiliation: Prof. Dr. Katrin Hartmann, Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München, Veterinärstraße 13, 80539 München, E-Mail: hartmann@uni-muenchen.de.
authors.forename: K
authors.initials: K
authors.lastname: Hartmann
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D018150:Avipoxvirus / Q000276:immunology; D001688:Biological Products / Q000627:therapeutic use*; D002371:Cat Diseases / Q000628:therapy*; D002415:Cats; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D011212:Poxviridae / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000627:therapeutic use; D015164:Vaccines, Inactivated / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D001688:Biological Products; C028621:PIND-AVI; C044867:PIND-ORF; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated
keywords: PIND-AVI; PIND-ORF; Parapoxvirus ovis; Zylexis®; innate immunity; treatment