title: The first international workshop on the epigenetics of osteoarthritis.
abstract: Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of disease-modifying drugs resulting, to a significant degree, from our incomplete understanding of the underlying molecular mechanisms of the disease. Emerging evidence points to a role of epigenetics in the pathogenesis of OA, but research in this area is still in its early stages. In order to summarize current knowledge and to facilitate the potential coordination of future research activities, the first international workshop on the epigenetics of OA was held in Amsterdam in October 2015. Recent findings on DNA methylation and hydroxymethylation, histone modifications, noncoding RNAs, and other epigenetic mechanisms were presented and discussed. The workshop demonstrated the advantage of bringing together those working in this nascent field and highlights from the event are summarized in this report in the form of summaries from invited speakers and organizers.
authors.affiliation: a Department of Medical Statistics and Bioinformatics, Section of Molecular Epidemiology , Leiden University Medical Center , Leiden , The Netherlands.
authors.forename: Ingrid M
authors.initials: IM
authors.lastname: Meulenbelt
authors.affiliation: b Department of Orthopaedic Surgery , Stanford University School of Medicine , Stanford , CA , USA.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Bhutani
authors.affiliation: a Department of Medical Statistics and Bioinformatics, Section of Molecular Epidemiology , Leiden University Medical Center , Leiden , The Netherlands.
authors.forename: Wouter
authors.initials: W
authors.lastname: den Hollander
authors.affiliation: c Department of Rheumatology , Center of Experimental Rheumatology, University Hospital Zurich , Zurich , Switzerland.
authors.forename: Steffen
authors.initials: S
authors.lastname: Gay
authors.affiliation: d Botnar Research Center, NIHR Oxford Biomedical Research Unit, Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK.|e Structural Genomics Consortium , University of Oxford , Oxford , UK.
authors.forename: Udo
authors.initials: U
authors.lastname: Oppermann
authors.affiliation: f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.
authors.forename: Louise N
authors.initials: LN
authors.lastname: Reynard
authors.affiliation: f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.|g Faculty of Medical Sciences, Bioinformatics Support Unit , Newcastle University , Newcastle-upon-Tyne , UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Skelton
authors.affiliation: f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.
authors.forename: David A
authors.initials: DA
authors.lastname: Young
authors.affiliation: h Department of Physiology and Pharmacology , Schulich School of Medicine and Dentistry, University of Western Ontario , London , ON , Canada.
authors.forename: Frank
authors.initials: F
authors.lastname: Beier
authors.affiliation: f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.
authors.forename: John
authors.initials: J
authors.lastname: Loughlin
mesh_terms: D000818:Animals; D003226:Congresses as Topic; D003718:Denmark; D057890:Epigenomics; D006801:Humans; D010003:Osteoarthritis
keywords: DNA methylation; epigenetics; histones; osteoarthritis; regulatory RNAs