title: Move over Tregs, MDSCs are here.
abstract: In this issue of Blood, Hou et al show the involvement of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of immune thrombocytopenia (ITP) and identify a novel mechanism by which high-dose dexamethasone (HD-DXM) promotes MDSC expansion and function and correlates with increased platelet counts.
authors.affiliation: ST. MICHAEL'S HOSPITAL.
authors.forename: John W
authors.initials: JW
authors.lastname: Semple
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D022423:Myeloid Cells / Q000187:drug effects*; D050784:Proto-Oncogene Protein c-ets-1 / Q000276:immunology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D050784:Proto-Oncogene Protein c-ets-1; D003907:Dexamethasone