title: Modeling the mechanical properties of liver fibrosis in rats.
abstract: The progression of liver fibrosis changes the biomechanical properties of liver tissue. This study characterized and compared different liver fibrosis stages in rats in terms of viscoelasticity. Three viscoelastic models, the Voigt, Maxwell, and Zener models, were applied to experimental data from rheometer tests and then the elasticity and viscosity were estimated for each fibrosis stage. The study found that both elasticity and viscosity are correlated with the various stages of liver fibrosis. The study revealed that the Zener model is the optimal model for describing the mechanical properties of each fibrosis stage, but there is no significant difference between the Zener and Voigt models in their performance on liver fibrosis staging. Therefore the Voigt model can still be effectively used for liver fibrosis grading.
authors.affiliation: Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen 518055, China; School of Biomedical Engineering, Shenzhen University, Shenzhen 518160, China; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen 518160, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen 518160, China; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen 518160, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen 518160, China; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen 518160, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen 518160, China; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen 518160, China.
authors.forename: Siping
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen 518160, China; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen 518160, China. Electronic address: shenyy@szu.edu.cn.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D018450:Disease Progression; D004548:Elasticity; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D055595:Mechanical Phenomena; D008954:Models, Biological; D051381:Rats; D014783:Viscosity
keywords: Complex modulus; Elasticity; Liver fibrosis; Maxwell model; Mechanical properties; Viscoelasticity; Viscosity; Voigt model; Zener model