title: Modified Canaloplasty: A New, Effective, and Safe Option for Glaucoma Patients With a Disrupted Schlemm Canal Wall.
abstract: We describe a modified canaloplasty technique and report the short-term efficacy for primary open-angle glaucoma (POAG) patients with disruption of Schlemm canal (SC) wall resulting from prior glaucoma surgery.
  
  
  
  This was a single-surgeon prospective cohort study. POAG patients scheduled for canaloplasty were included and divided into 2 groups: group1 included POAG patients without a history of glaucoma surgery and group 2 included POAG patients with failed glaucoma surgery and disrupted SC. The status of SC was determined by gonioscopy and ultrasound biomicroscopy. Standard canaloplasty procedures were performed in group 1. A modified canaloplasty technique was used in group 2. Primary outcome measures included the intraocular pressure and glaucoma medication use at various follow-up points.
  
  
  
  Seventeen patients were enrolled in group 1 and 9 patients were enrolled in group 2. At the 12-month follow-up, there was no significant difference between groups 1 and 2 (17.8±2.7 vs. 16.7±2.4 mm Hg, respectively; P=0.362) and in the mean number of medications (0.9±1.2 vs. 0.3±0.5, respectively; P=0.061). In both groups, at all follow-up points, the intraocular pressure and the mean glaucoma medication usage had decreased significantly compared with measurements at baseline (P<0.001). The rate for successful circumferential catheterization was not significant between the 2 groups (88.2% vs. 77.8%, P=0.063).
  
  
  
  Modified canaloplasty is a feasible, safe, and potentially effective option for patients with POAG and regions of SC disruption resulting from previous glaucoma-filtering surgery.
authors.affiliation: *Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University †Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xin
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Huaizhou
authors.initials: H
authors.lastname: Wang
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
mesh_terms: D000328:Adult; D002404:Catheterization / Q000379:methods; D005260:Female; D018463:Filtering Surgery / Q000379:methods*; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D016850:Limbus Corneae / Q000601:surgery*; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D011446:Prospective Studies; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology