title: Synthesis of 3,3-Spiroindolines via FeCl3-Mediated Cyclization of Aryl- or Alkene-Containing 3-Substituted N-Ac Indoles.
abstract: We report the cyclization of 3-substituted N-acetylindoles for the straightforward synthesis of 3,3-spiroindolines via the Friedel-Crafts reaction of an appended aryl group or the formal [2 + 2] cycloaddition of an appended alkene. Our strategy involves an Umpolung of the C2═C3 bond of the indole nucleus during FeCl3-mediated hydroarylation or annulation reactions.
authors.affiliation: Univ Paris Sud, CNRS, Université Paris-Saclay , Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe Méthodologie, Synthèse et Molécules Thérapeutique (MS&MT), Bat. 410, 91405 Orsay, France.
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Nandi
authors.affiliation: Univ Paris Sud, CNRS, Université Paris-Saclay , Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe Méthodologie, Synthèse et Molécules Thérapeutique (MS&MT), Bat. 410, 91405 Orsay, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Guillot
authors.affiliation: Univ Paris Sud, CNRS, Université Paris-Saclay , Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe Méthodologie, Synthèse et Molécules Thérapeutique (MS&MT), Bat. 410, 91405 Orsay, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Kouklovsky
authors.affiliation: Univ Paris Sud, CNRS, Université Paris-Saclay , Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe Méthodologie, Synthèse et Molécules Thérapeutique (MS&MT), Bat. 410, 91405 Orsay, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vincent