title: Role of Melatonin in the Regulation of Differentiation of T Cells Producing Interleukin-17 (Th17).
abstract: We studied the ability of melatonin in physiological and pharmacological concentrations to induce and/or regulate differentiation of T cells producing IL-17 (Th17). This hormone produced the opposite effect on CD4+T cells, which depended on their activation status. Melatonin induced the synthesis of IL-17A by intact T cells, but had little effect on activated cells. Melatonin in high (pharmacological) concentration decreased the intracellular expression of this cytokine under conditions of polyclonal activation. Melatonin had a dose-depended effect. Taking into the fact that Th17 cells play an important role in the immune defense, it can be suggested that the regulation of their activity by melatonin contributes to this process.
authors.affiliation: Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia. ibis_072@mail.ru.
authors.forename: E M
authors.initials: EM
authors.lastname: Kuklina
authors.affiliation: Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia.
authors.forename: N S
authors.initials: NS
authors.lastname: Glebezdina
authors.affiliation: Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Nekrasova
mesh_terms: D000328:Adult; D002454:Cell Differentiation / Q000187:drug effects*; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000276:immunology; D008550:Melatonin / Q000494:pharmacology*; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000096:biosynthesis; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000096:biosynthesis; D058504:Th17 Cells / Q000166:cytology* / Q000276:immunology
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539738:RORA protein, human; C539900:RORC protein, human; D008550:Melatonin
keywords: T cells; Th17; differentiation; melatonin