title: Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis.
abstract: The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard(®), Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate(®), Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg) on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period.
authors.affiliation: Merial S.A.S., 29 avenue Tony Garnier, 69007 Lyon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Beugnet
authors.affiliation: Merial S.A.S., 29 avenue Tony Garnier, 69007 Lyon, France.
authors.forename: Lénaïg
authors.initials: L
authors.lastname: Halos
authors.affiliation: Merial S.A.S., 29 avenue Tony Garnier, 69007 Lyon, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Larsen
authors.affiliation: Clinvet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South Africa.
authors.forename: Christa
authors.initials: C
authors.lastname: de Vos
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D012867:Skin / Q000469:parasitology; D013607:Tablets; D013997:Time Factors
chemical_list: D056810:Acaricides; D007093:Imidazoles; D007555:Isoxazoles; D018942:Macrolides; D009281:Naphthalenes; D000073943:Neonicotinoids; D009574:Nitro Compounds; D013607:Tablets; C000589002:afoxolaner; C082359:imidacloprid; C027837:moxidectin