title: Dissociation of Cross-Sectional Trajectories for Verbal and Visuo-Spatial Working Memory Development in Rubinstein-Taybi Syndrome.
abstract: Working memory (WM) impairments might amplify behavioural difference in genetic syndromes. Murine models of Rubinstein-Taybi syndrome (RTS) evidence memory impairments but there is limited research on memory in RTS. Individuals with RTS and typically developing children completed WM tasks, with participants with RTS completing an IQ assessment and parents/carers completing the Vineland Adaptive Behavior Scales. A cross-sectional trajectory analysis was conducted. There were significant WM span deficits in RTS relative to mental age. Verbal WM span was positively associated with mental age; however, this was not observed for visuo-spatial span. There is a dissociation between WM domains in RTS. Individuals may have difficulties with tasks relying on WM span, above difficulties predicted by overall ability.
authors.affiliation: School of Psychology, Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. j.e.waite@bham.ac.uk.
authors.forename: Jane
authors.initials: J
authors.lastname: Waite
authors.affiliation: School of Psychology, University of Birmingham, Birmingham, UK.
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Beck
authors.affiliation: School of Psychology, Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Mary
authors.initials: M
authors.lastname: Heald
authors.affiliation: Specialist Learning Disability and Forensic Services, Hertfordshire Partnership NHS Foundation Trust, Hemel Hempstead, UK.
authors.forename: Laurie
authors.initials: L
authors.lastname: Powis
authors.affiliation: School of Psychology, Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Oliver
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology*; D012415:Rubinstein-Taybi Syndrome / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult
keywords: Dissociation; Rubinstein–Taybi syndrome; Short-term memory; Typically developing children; Working memory