title: Cells of Benign and Borderline Thyroid Tumor Express Malignancy Markers.
abstract: We studied expression of malignancy markers galectin-3, cytokeratin-19, HBME-1, fibronectin, and cyclin D1 in cells of benign (n=51), malignant (n=87), and borderline (n=53) tumors. The results indicate that 3.9% benign and 41.5% borderline tumors express malignancy markers (specificity 98-100%). Follow up over 1-10 years after surgical treatment for borderline tumors showed no progression of tumor growth. We conclude that some benign and borderline tumors represent low-grade neoplasms with favorable prognosis.
authors.affiliation: Endocrinology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia. abrosim@mrrc.obninsk.ru.|MISIS National Research Technological University, Moscow, Russia. abrosim@mrrc.obninsk.ru.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Abrosimov
authors.affiliation: A. F. Tsyb Medical Radiology Center, Affiliated Department of P. A. Hertzen Federal Medical Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Dvinskikh
authors.affiliation: A. F. Tsyb Medical Radiology Center, Affiliated Department of P. A. Hertzen Federal Medical Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sidorin
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D019938:Cyclin D1 / Q000096:biosynthesis*; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis*; D037502:Galectin 3 / Q000096:biosynthesis*; D006801:Humans; D053539:Keratin-19 / Q000096:biosynthesis*; D008297:Male; D013961:Thyroid Gland / Q000473:pathology / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D055815:Young Adult; D000951:Antigens, Neoplasm
chemical_list: D014408:Biomarkers, Tumor; D019938:Cyclin D1; D005353:Fibronectins; D037502:Galectin 3; D053539:Keratin-19; C530104:CCND1 protein, human; C432845:HBME-1 antigen; D000951:Antigens, Neoplasm
keywords: immunohistochemistry; malignant potential; thyroid; tumors