title: Quercetin, Inflammation and Immunity.
abstract: In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability. This review focuses on the physicochemical properties, dietary sources, absorption, bioavailability and metabolism of quercetin, especially main effects of quercetin on inflammation and immune function. According to the results obtained both in vitro and in vivo, good perspectives have been opened for quercetin. Nevertheless, further studies are needed to better characterize the mechanisms of action underlying the beneficial effects of quercetin on inflammation and immunity.
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China. liyao@neau.edu.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China. qiumengyouzhi@163.com.
authors.forename: Jiaying
authors.initials: J
authors.lastname: Yao
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China. hanchunyan920317@163.com.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Han
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China. jiaxinyang8040@163.com.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Yang
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China. mariach046@yahoo.com.
authors.forename: Maria Tabassum
authors.initials: MT
authors.lastname: Chaudhry
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China. 13674620839@163.com.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy, Livestock, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical, Agriculture, Chinese Academy of Sciences, Changsha 410125, China. liuhn@isa.ac.cn.
authors.forename: Hongnan
authors.initials: H
authors.lastname: Liu
authors.affiliation: Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy, Livestock, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical, Agriculture, Chinese Academy of Sciences, Changsha 410125, China. yinyulong@isa.ac.cn.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001682:Biological Availability; D004032:Diet; D019587:Dietary Supplements / Q000009:adverse effects; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D007408:Intestinal Absorption; D011794:Quercetin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D064167:Recommended Dietary Allowances; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D011794:Quercetin
keywords: dietary sources; immune function; inflammation; metabolism; quercetin