title: Association of rs4331426 and rs2057178 with Risk of Tuberculosis: Evidence from a Meta-Analysis.
abstract: OBJECTIVE
  A growing number of genome-wide association studies (GWAS) have revealed associations between single-nucleotide polymorphisms (SNPs) and susceptibility to tuberculosis (TB). However, the results of these studies have been inconclusive. This study evaluated whether the SNPs rs4331426 and rs2057178, identified by GWAS, are associated with TB susceptibility.
  
  
  METHODS
  We performed meta-analyses for rs4331426, based on eight case-control studies which included a total of 4988 TB cases and 9041 controls; and rs2057178, based on five case-control studies, including a total of 9400 TB cases and 14,459 controls.
  
  
  RESULTS
  Our meta-analyses indicated that both rs4331426 and rs2057178 were associated with increased risk of TB (G vs. A: odds ratio [OR] = 1.15, 95% confidence interval [CI]: 1.08-1.22 and A vs. G: OR = 0.84, 95% CI: 0.80-0.88, respectively), especially in an African subgroup. However, no significant TB association was found with rs4331426 in an Asian subgroup.
  
  
  CONCLUSIONS
  These meta-analyses indicate that rs4331426 and rs2057178 might play a role in the risk of developing TB, especially in Africans; however, rs4331426 might not play a significant role in the risk of developing TB in Asians.
authors.affiliation: 1 College of Medical Technology and Engineering, Henan University of Science and Technology , Luoyang, Henan, China .
authors.forename: Yun
authors.initials: Y
authors.lastname: Xue
authors.affiliation: 1 College of Medical Technology and Engineering, Henan University of Science and Technology , Luoyang, Henan, China .
authors.forename: Xuefei
authors.initials: X
authors.lastname: Bai
authors.affiliation: 1 College of Medical Technology and Engineering, Henan University of Science and Technology , Luoyang, Henan, China .
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Hu
authors.affiliation: 2 College of Animal Science and Technology, Henan University of Science and Technology , Luoyang, Henan, China .
authors.forename: Zhanqin
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: 1 College of Medical Technology and Engineering, Henan University of Science and Technology , Luoyang, Henan, China .
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: 1 College of Medical Technology and Engineering, Henan University of Science and Technology , Luoyang, Henan, China .
authors.forename: Yuehong
authors.initials: Y
authors.lastname: Xia
authors.affiliation: 1 College of Medical Technology and Engineering, Henan University of Science and Technology , Luoyang, Henan, China .
authors.forename: Weina
authors.initials: W
authors.lastname: Gao
authors.affiliation: 3 Life Sciences School of Hubei University , Wuhan, Hubei, China .
authors.forename: Fan
authors.initials: F
authors.lastname: Chen
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D002135:Calcium-Binding Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D016022:Case-Control Studies; D004706:Endodeoxyribonucleases; D016162:Genes, Wilms Tumor; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D022661:RNA, Untranslated / Q000235:genetics; D014376:Tuberculosis / Q000235:genetics*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; C063419:CTAGE1 protein, human; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D009687:Nuclear Proteins; C000597745:RCN1 protein, human; D022661:RNA, Untranslated; D004706:Endodeoxyribonucleases; C410741:RBBP8 protein, human