title: Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies.
abstract: Chronic liver diseases represent a significant public health problem worldwide. The degree of liver fibrosis secondary to these diseases is important, because it is the main predictor of their evolution and prognosis. Hyaluronic acid is studied as a non-invasive marker of liver fibrosis in chronic liver diseases, in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of fibrosis. We review the advantages and limitations of hyaluronc acid, a biomarker, used to manage patients with chronic viral hepatitis B or C infection, non-alcoholic fatty liver disease, HIV-HCV coinfection, alcoholic liver disease, primary biliary cirrhosis, biliary atresia, hereditary hemochromatosis and cystic fibrosis.
authors.affiliation: 4th Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Olga Hilda
authors.initials: OH
authors.lastname: Orasan
authors.affiliation: 4th Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: George
authors.initials: G
authors.lastname: Ciulei
authors.affiliation: 4th Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Angela
authors.initials: A
authors.lastname: Cozma
authors.affiliation: 4th Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Madalina
authors.initials: M
authors.lastname: Sava
authors.affiliation: 2nd Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Dan Lucian
authors.initials: DL
authors.lastname: Dumitrascu
keywords: chronic liver diseases; hyaluronic acid; liver fibrosis