title: Liver cirrhosis leads to poorer survival in patients with end-stage renal disease.
abstract: OBJECTIVE
  Liver cirrhosis (LC) is an important problem in patients withend-stage renal disease (ESRD). Few studies have investigated the inf luence ofLC on mortality in patients with ESRD. This study investigated the associationbetween LC and mortality among patients with ESRD and compare mortality betweentwo dialysis modalities.
  
  
  METHODS
  Adult patients (≥ 18 years of age) starting dialysis for ESRD were enrolledin the present study from 2000 to 2011. We analyzed 1,069 patients withESRD; of these, 742 patients were undergoing hemodialysis (HD) and 327 patientswere undergoing peritoneal dialysis (PD).
  
  
  RESULTS
  The prevalence of LC was 44 of 1,069 patients (4.1%). The cumulative 1-,3-, and 5-year survival rates of noncirrhotic patients were 93%, 83%, and 73%, respectively,whereas the equivalent survival rates of cirrhotic patients were 90%,68%, and 48%, respectively (p = 0.011). After adjustment, LC was an independentrisk factor for death in patients with ESRD. No difference in mortality associatedwith LC was found between the HD and PD subgroups.
  
  
  CONCLUSIONS
  Of the patients with ESRD, cirrhotic patients had poorer survivalthan noncirrhotic patients. Among patients with ESRD and LC, survival of patientsundergoing PD may be comparable with that of patients undergoing HD.
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Ae Jin
authors.initials: AJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Han
authors.initials: H
authors.lastname: Ro
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000401:mortality*; D015995:Prevalence; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
keywords: Hemodialysis; Liver cirrhosis; Mortality; Peritoneal dialysis