title: Genetic association of PROC variants with pulmonary embolism in Northern Chinese Han population.
abstract: To evaluate SNPs (single nucleotide polymorphism) in PROC (protein C gene) associated with pulmonary embolism (PE) susceptibility in North Chinese Han population. A case-control study design was used, and patients with PE and healthy participants were enrolled from the Emerging Department of the several hospitals in Weifang, Shandong, China. SNPs in PROC were genotyped using Mass ARRAY system. The allele frequency of rs199469469 was significantly different between PE patients and the control [OR (95 % CI) = 5.00 (1.66-15.12), P = 0.004], and the difference remained significantly after controlling for age and gender [OR (95 % CI) = 5.34 (1.47-19.39), P = 0.011). The G(del)G in the haplotype includes rs1799809|rs199469469|rs2069928 was of a significantly difference (P = 0.016) among PE patients and the controls, and remained significant (P = 0.015) after adjustment for age and sex. Our study reports that PROC SNPs (rs199469469) might be associated with PE susceptibility, with the G allele of rs199469469 serving as the protective factors for incidence of PE. These findings may contribute to the understanding and primary prevention of PE.
authors.affiliation: Department of Thorax, Anqiu People's Hospital, Weifang, 262100 China.
authors.forename: Zengliang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Brain EMG, Anqiu People's Hospital, Weifang, 262100 China.
authors.forename: Tianhe
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Weifang People's Hospital, Weifang, 261021 China.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Neurology, Anqiu People's Hospital, Weifang, 262100 China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Weifang Brain Hospital, Weifang People's Hospital, Weifang, 261021 China.
authors.forename: Chengdong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Surgery, Anqiu Municipal Hospital, Weifang, 262100 China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nephrology, Anqiu People's Hospital, Weifang, 262100 China.
authors.forename: Xuhe
authors.initials: X
authors.lastname: Lang
authors.affiliation: Department of Neurosurgery, Weifang People's Hospital, Weifang, 261021 China.
authors.forename: Shimei
authors.initials: S
authors.lastname: Jing
authors.affiliation: Department of Neurosurgery, People's Hospital of Weifang High Tech Industry Development Zone, Weifang, 261041 China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Weifang People's Hospital, Weifang, 261021 China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Wang
keywords: PROC (protein C gene); Pulmonary embolism; Single nucleotide polymorphism