title: Coffee Consumption and Pancreatic Cancer Risk: An Update Meta-analysis of Cohort Studies.
abstract: OBJECTIVE
  The results of epidemiologic studies on the relationship between the coffee consumption and pancreatic cancer risk were inconsistent. Thus, we performed an update meta-analysis of cohort studies to quantitatively summarize the association between coffee consumption and pancreatic cancer risk.
  
  
  METHODS
  We searched CBM (China Biology Medicine disc) and MEDLINE for studies of coffee consumption and pancreatic cancer risk up to June 2015. A total of 20 cohort studies were identified in this meta-analysis, and we analyzed these studies using random effects model. The dose-response analysis was conducted too.
  
  
  RESULTS
  The overall relative risk (RR) for highest coffee consumption versus lowest coffee consumption was 0.75 (95% Confidence Interval (CI), 0.63-0.86). Statistic significant heterogeneity was found among these studies (I (2) =37.8%, P for heterogeneity =0.045). The pooled RR for increment of 1 cup/day of coffee consumption was 0.99 (95%CI, 0.96-1.03) for the nine studies, without statistically significant.
  
  
  CONCLUSIONS
  High coffee consumption is associated with a reduced pancreatic cancer risk. However, the result should be accepted with caution, due to the potential confounder and bias could not be excluded. Further well designed studies are needed to confirm the finding.
authors.affiliation: Dr. Heng-Quan Ran, MD, Division of Hepatobiliary Pancreatic Surgery, Panzhihua Central Hospital, Sichuan Province, China.
authors.forename: Heng-Quan
authors.initials: HQ
authors.lastname: Ran
authors.affiliation: Dr. Jun-Zhou Wang, MD, Division of Hepatobiliary Pancreatic Surgery, Panzhihua Central Hospital, Sichuan Province, China.
authors.forename: Jun-Zhou
authors.initials: JZ
authors.lastname: Wang
authors.affiliation: Dr. Chang-Qin Sun, MD, Division of Hepatobiliary Pancreatic Surgery, Panzhihua Central Hospital, Sichuan Province, China.
authors.forename: Chang-Qin
authors.initials: CQ
authors.lastname: Sun
keywords: Coffee; Meta-analysis; Pancreatic cancer