title: Enhancing panic and smoking reduction treatment with d-cycloserine: Study protocol for a randomized controlled trial.
abstract: There has been relatively little attention focused on treatment strategies for smokers with panic attacks despite their increased risk of relapse. Panic and Smoking Reduction Treatment (PSRT) integrates standard smoking cessation treatment with an exposure-based intervention targeting the mechanisms underlying panic-smoking relations. Building upon emerging evidence supporting the efficacy of d-cycloserine (DCS) for augmenting exposure-based therapy, we are conducting an initial test of the efficacy of DCS for enhancing PSRT outcomes. Utilizing a randomized, double-blind trial comparing PSRT+DCS to PSRT+placebo, we will obtain initial effect sizes for short-term and long-term smoking cessation outcomes and perform an initial test of putative mechanisms.
authors.affiliation: Department of Psychology, Institute for Mental Health Research, University of Texas at Austin, Austin, TX, United States. Electronic address: smits@utexas.edu.
authors.forename: Jasper A J
authors.initials: JA
authors.lastname: Smits
authors.affiliation: Department of Psychology, University of Houston, Houston, TX, United States.
authors.forename: Brooke Y
authors.initials: BY
authors.lastname: Kauffman
authors.affiliation: Department of Psychology, Institute for Mental Health Research, University of Texas at Austin, Austin, TX, United States.
authors.forename: Eunjung
authors.initials: E
authors.lastname: Lee-Furman
authors.affiliation: Department of Psychology, University of Houston, Houston, TX, United States; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zvolensky
authors.affiliation: Psychological and Brain Sciences, Boston University, Boston, MA, United States.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Otto
authors.affiliation: Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Piper
authors.affiliation: Department of Psychology, Institute for Mental Health Research, University of Texas at Austin, Austin, TX, United States.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Powers
authors.affiliation: Department of Psychology, Southern Methodist University, Dallas, TX, United States.
authors.forename: David
authors.initials: D
authors.lastname: Rosenfield
mesh_terms: D000963:Antimetabolites / Q000627:therapeutic use*; D003523:Cycloserine / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D007171:Implosive Therapy / Q000379:methods*; D016584:Panic Disorder / Q000523:psychology / Q000628:therapy*; D012907:Smoking / Q000523:psychology / Q000628:therapy*; D016540:Smoking Cessation / Q000379:methods*
chemical_list: D000963:Antimetabolites; D003523:Cycloserine
keywords: Augmentation; Behavioral intervention; Clinical trial; Panic; Smoking cessation; d-Cycloserine