title: Ribbon structure stabilized by C10 and C12 turns in αγ hybrid peptide.
abstract: The present study describes the synthesis and crystallographic analysis of αγ hybrid peptides, Boc-Gpn-L-Pro-NHMe (1), Boc-Aib-Gpn-L-Pro-NHMe (2), and Boc-L-Pro-Aib-Gpn-L-Pro-NHMe (3). Peptides 1 and 2 adopt expanded 12-membered (C12 ) helical turn over γα segment. Peptide 3 promotes the ribbon structure stabilized by type II β-turn (C10 ) followed by the expanded C12 helical γα turn. Both right-handed and left-handed helical conformations for Aib residue are observed in peptides 2 and 3, respectively.
authors.affiliation: Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, 180001, India.
authors.forename: Naiem Ahmad
authors.initials: NA
authors.lastname: Wani
authors.affiliation: X-ray Crystallography Laboratory, Post-Graduate Department of Physics and Electronics, University of Jammu, Jammu Tawi, 180 006, India.
authors.forename: Rajni
authors.initials: R
authors.lastname: Kant
authors.affiliation: X-ray Crystallography Laboratory, Post-Graduate Department of Physics and Electronics, University of Jammu, Jammu Tawi, 180 006, India.
authors.forename: Vivek Kumar
authors.initials: VK
authors.lastname: Gupta
authors.affiliation: Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, 180001, India.
authors.forename: Subrayashastry
authors.initials: S
authors.lastname: Aravinda
authors.affiliation: Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, 180001, India.|Academy of Scientific and Innovative Research, New Delhi, India.
authors.forename: Rajkishor
authors.initials: R
authors.lastname: Rai
mesh_terms: D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D000072756:Protein Conformation, alpha-Helical; D055550:Protein Stability
chemical_list: D009842:Oligopeptides
keywords: expanded turn; hybrid peptides; ribbon structure; γ-amino acid, conformation