title: Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics.
abstract: Although disproportionately affected by increasing rates of type 2 diabetes and dyslipidemias, Hispanic populations are underrepresented in efforts to understand genetic susceptibility to these disorders. Where research has been undertaken, these populations have provided substantial insight into identification of novel risk-associated genes and have aided in the ability to fine map previously described risk loci. Genome-wide analyses in Hispanic and trans-ethnic populations have resulted in identification of more than 40 replicated or novel genes with significant effects for type 2 diabetes or lipid traits. Initial investigations into rare variant effects have identified new risk-associated variants private to Hispanic populations, and preliminary results suggest metagenomic approaches in Hispanic populations, such as characterizing the gut microbiome, will enable the development of new predictive tools and therapeutic targets for type 2 diabetes. Future genome-wide studies in expanded cohorts of Hispanics are likely to result in new insights into the genetic etiology of metabolic health.
authors.affiliation: The Human Genetics Center, University of Texas School of Public Health, Houston, TX, USA. jennifer.e.below@uth.tmc.edu.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Below
authors.affiliation: Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada.
authors.forename: Esteban J
authors.initials: EJ
authors.lastname: Parra
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006630:Hispanic or Latino; D006801:Humans; D008055:Lipids / Q000235:genetics*; D054892:Metagenome; D012307:Risk Factors
chemical_list: D008055:Lipids
keywords: Genome-wide studies; Hispanics; Lipids; Type 2 diabetes