title: Single molecule study of initial structural features on the amyloidosis process.
abstract: We employed an α-hemolysin (α-HL) nanopore as a single-molecule tool to investigate the effects of initial structure on the amyloidosis process. The differences in the initial structure of two β-amyloid (Aβ) peptides (Aβ25-35 and Aβ35-25) could be distinguished in real-time due to their characteristic blockades. More importantly, the distinct aggregate dynamics for these two kinds of Aβ fragments can be readily analyzed by monitoring the blockade frequency over time.
authors.affiliation: Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China. yilunying@ecust.edu.cn ytlong@ecust.edu.cn.
authors.forename: Yong-Xu
authors.initials: YX
authors.lastname: Hu
authors.affiliation: Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China. yilunying@ecust.edu.cn ytlong@ecust.edu.cn.
authors.forename: Yi-Lun
authors.initials: YL
authors.lastname: Ying
authors.affiliation: Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China. yilunying@ecust.edu.cn ytlong@ecust.edu.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China. yilunying@ecust.edu.cn ytlong@ecust.edu.cn.
authors.forename: Chan
authors.initials: C
authors.lastname: Cao
authors.affiliation: School of Information Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
authors.forename: Bing-Yong
authors.initials: BY
authors.lastname: Yan
authors.affiliation: School of Information Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
authors.forename: Hui-Feng
authors.initials: HF
authors.lastname: Wang
authors.affiliation: Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China. yilunying@ecust.edu.cn ytlong@ecust.edu.cn.
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism*; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)