title: Arachidonic acid needed in infant formula when docosahexaenoic acid is present.
abstract: Recently, the European Food Safety Authority asserted that arachidonic acid (ARA) is an optional nutrient for the term infant even when docosahexaenoic acid (DHA) is present. The brief rationale is based on an explicit, widespread misapplication of the concept of "essential fatty acids" to linoleic acid that implies it is uniquely required as a nutrient per se. Linoleic acid prevents acute clinical symptoms caused by polyunsaturated fatty acid-deficient diets and is the major precursor for ARA in most human diets. Experimental diets with ARA as the sole n-6 similarly prevent symptoms but at a lower energy percentage than linoleic acid and show ARA is a precursor for linoleic acid. The absence of consistent evidence of ARA benefit from randomized controlled trials is apparently an issue as well. This review highlights basic and clinical research relevant to ARA requirements as an adjunct to DHA in infancy. ARA is a major structural central nervous system component, where it rapidly accumulates perinatally and is required for signaling. Tracer studies show that ARA-fed infants derive about half of their total body ARA from dietary preformed ARA. Clinically, of the 3 cohorts of term infants studied with designs isolating the effects of ARA (DHA-only vs DHA+ARA), none considered ARA-specific outcomes such as vascular or immune function; the study with the highest ARA level showed significant neurocognitive benefit. All breastfed term infants of adequately nourished mothers consume both DHA and ARA. The burden of proof to substantially deviate from the composition of breastmilk is greater than that available from inherently empirical human randomized controlled trial evidence. Infant formulas with DHA but without ARA risk harm from suppression of ARA-mediated metabolism manifest among the many unstudied functions of ARA.
authors.affiliation: J.T. Brenna is with the Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA. jtb4@cornell.edu.
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Brenna
mesh_terms: D016718:Arachidonic Acid / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D004281:Docosahexaenoic Acids / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D005228:Fatty Acids, Essential / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D019787:Linoleic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D008895:Milk, Human / Q000737:chemistry; D009751:Nutritional Requirements
chemical_list: D004041:Dietary Fats; D005228:Fatty Acids, Essential; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D019787:Linoleic Acid
keywords: arachidonic acid; docosahexaenoic acid; infant formula; linoleic acid; long-chain polyunsaturated fatty acids