title: Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis.
abstract: We conducted a meta-analysis to explore the relationships between p14ARF gene methylation and clinicopathological features of colorectal cancer (CRC). Databases, including Pubmed, Embase and Cochrane Library, were searched and, finally, a total of 18 eligible researches encompassing 1988 CRC patients were selected. Combined odds ratios (ORs) with 95% confidence intervals (95% CIs) were evaluated under a fixed effects model for absence of heterogeneity. Significant associations were observed between p14ARF gene methylation and tumor location (OR = 2.35, 95% CI: 1.55-3.55, P = 0.001), microsatellite instability (MSI) status (OR = 3.28, 95% CI: 2.12-5.07, P<0.0001). However, there were no significant associations between p14ARF gene methylation and tumor stage, tumor differentiation. We concluded that p14ARF gene methylation may be significantly associated with tumor location, and MSI status of CRC.
authors.affiliation: Division of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 W, Yanta Road, Xi'an, 710061, Shaanxi, China.
authors.forename: Zhangjian
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Division of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 W, Yanta Road, Xi'an, 710061, Shaanxi, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Division of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 W, Yanta Road, Xi'an, 710061, Shaanxi, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Lai
authors.affiliation: Division of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 W, Yanta Road, Xi'an, 710061, Shaanxi, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Diao
authors.affiliation: Division of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 W, Yanta Road, Xi'an, 710061, Shaanxi, China.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Li
authors.affiliation: Division of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 W, Yanta Road, Xi'an, 710061, Shaanxi, China.
authors.forename: Chengxue
authors.initials: C
authors.lastname: Dang
authors.affiliation: Division of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 W, Yanta Road, Xi'an, 710061, Shaanxi, China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Song
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D019175:DNA Methylation / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D017594:Publication Bias; D025803:Tumor Suppressor Protein p14ARF / Q000235:genetics*
chemical_list: D025803:Tumor Suppressor Protein p14ARF