title: Prediction of the response of ocular adnexal lymphoma to chemotherapy using combined pretreatment dynamic contrast-enhanced and diffusion-weighted MRI.
abstract: Background There are no established biomarkers predictive of the efficacy of treatment for ocular adnexal lymphoma (OAL). Purpose To evaluate the effectiveness of pretreatment dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting the response of OAL to chemotherapy. Material and Methods Twenty-one patients, who were pathologically diagnosed with OAL, were retrospectively analyzed. According to the National Comprehensive Cancer Network (NCCN) response evaluation criteria for non-Hodgkin's lymphoma, patients were divided into responders (n = 14) and non-responders (n = 7). The volume transfer constant (Ktrans), rate constant (Kep), extracellular extravascular volume fraction (Ve), and apparent diffusion coefficient (ADC) were computed. Two independent-sample tests were applied for statistical analysis. For significantly different parameters, receiver-operator characteristics curve analysis was performed. Results The Ktransvalue (min-1), Kepvalue (min-1), and ADC value (10-3mm2/s) were 0.76 ± 0.36 vs. 0.47 ± 0.18 (mean ± SD), 4.43 ± 1.29 vs. 3.14 ± 1.37, and 0.51 ± 0.12 vs. 0.66 ± 0.15, respectively, in the responders and non-responders groups. Significant differences were found between the two groups regarding these parameters ( P < 0.05). However, no significant difference was observed in Ve (min-1) between the groups ( P > 0.05). Ktrans, Kep, and ADC had a moderately predictive sensitivity or specificity. When Ktransand ADC or the three parameters were combined, a considerably higher sensitivity (85.7%) and specificity (85.7%) with a significant discriminative accuracy (area under the curve = 0.929; P = 0.002) was found. Conclusion Ktrans, Kep, and ADC could potentially predict OAL response to chemotherapy. A combination of these DWI and DCE-MRI quantitative parameters might increase sensitivity and specificity.
authors.affiliation: 1 Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, PR China.|2 Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Pengde
authors.initials: P
authors.lastname: Guo
authors.affiliation: 2 Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Liu
authors.affiliation: 2 Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yan
authors.affiliation: 3 Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: 3 Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Wei
authors.affiliation: 2 Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Lv
authors.affiliation: 4 Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Zhenchang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 2 Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Junfang
authors.initials: J
authors.lastname: Xian
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media
keywords: Diffusion-weighted imaging (DWI); dynamic contrast-enhanced imaging (DCE-MRI); lymphoma; magnetic resonance imaging (MRI)