title: Product-Derived Bimetallic Palladium Complex Catalyzes Direct Carbonylation of Sulfonylazides.
abstract: A novel product-derived bimetallic palladium complex catalyzes a sulfonylazide-transfer reaction with the σ-donor/π-acceptor ligand CO, and is advantageous given its broad substrate scope, high efficiency, and mild reaction conditions (atmospheric pressure of CO at room temperature). This methodology provides a new approach to sulfonylureas, which are present in both pharmaceuticals and agrochemicals. The synthesis of Glibenclamide on a gram scale further revealed the practical utility of this procedure. Mechanistically, the generation of a bridged bimetallic palladium species derived from the product sulfonylurea is disclosed as the crucial step for this catalytic cycle.
authors.affiliation: Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing, 100193, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing, 100193, China.
authors.forename: Zongyang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing, 100193, China.
authors.forename: Shaole
authors.initials: S
authors.lastname: Song
authors.affiliation: Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing, 100193, China.
authors.forename: Ming-An
authors.initials: MA
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing, 100193, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Fu
authors.affiliation: Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing, 100193, China. zhangzhh@cau.edu.cn.
authors.forename: Zhenhua
authors.identifier: 0000-0002-6579-1670
authors.initials: Z
authors.lastname: Zhang
keywords: azides; carbonylation; palladium; reaction mechanisms; structure elucidation