title: [THE INCONSISTENCIES OF REGULATION OF METABOLISM IN PHYLOGENESIS AT THREE LEVELS OF "RELATIVE BIOLOGICAL PERFECTION": ETIOLOGY OF METABOLIC PANDEMICS].
abstract: The regulation of metabolism in vivo can be comprehended by considering stages of becoming inphylogenesis of humoral, hormonal, vegetative regulators separately: at the level of cells; in paracrin-regulated cenosises of cells; organs and systems under open blood circulation and closed system of blood flow. The levels of regulations formed at different stages of phylogenesis. Their completion occurred at achievement of "relative biological perfection". Only this way need of cells in functional, structural interaction and forming of multicellular developed. The development of organs and systems of organs also completed at the level of "relative biological perfection". From the same level the third stage of becoming of regulation of metabolism at the level of organism started. When three conditions of "relative biological perfection" achieved consequently at level in vivo are considered in species Homo sapiens using system approach it is detected that "relative biological perfection" in vivo is accompanied by different inconsistencies of regulation of metabolism. They are etiologic factors of "metabolic pandemics ". The inconsistencies (etiological factors) are consider as exemplified by local (at the level of paracrin-regulated cenosises of cells) and system (at the level of organism) regulation of biological reaction metabolism-microcirculation that results in dysfunction of target organs and development of pathogenesis of essential metabolic arterial hypertension. The article describes phylogenetic difference between visceral fatty cells and adpocytes, regulation of metabolism by phylogenetically late insulin, reaction of albumin at increasing of content of unesterified fatty acids in blood plasma, difference of function of resident macrophage and monocytes-macrophages in pathogenesis of atherosclerosis, metabolic syndrome, insulin resistance, obesity, under diabetes mellitus and essential metabolic arterial hypertension.
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
mesh_terms: D017667:Adipocytes / Q000145:classification / Q000378:metabolism / Q000473:pathology; D000418:Albumins / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000075222:Essential Hypertension; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D053858:Metabolic Networks and Pathways / Q000235:genetics; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008833:Microcirculation / Q000235:genetics; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D038081:Organogenesis / Q000235:genetics; D058873:Pandemics; D019899:Paracrine Communication / Q000235:genetics; D010802:Phylogeny
chemical_list: D000418:Albumins; D005230:Fatty Acids, Nonesterified; D007328:Insulin