title: In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses.
abstract: There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity.
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: mko2@cdc.gov.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Lo
authors.affiliation: Department of Biochemistry and Molecular Biology, Department of Phamarcology and Toxicology, Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA; Novartis Institute for Tropical Diseases, Singapore. Electronic address: peshi@utmb.edu.
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Shi
authors.affiliation: Novartis Institute for Tropical Diseases, Singapore.
authors.forename: Yen-Liang
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Mike
authors.initials: M
authors.lastname: Flint
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: ccs8@cdc.gov.
authors.forename: Christina F
authors.initials: CF
authors.lastname: Spiropoulou
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005416:Flavivirus / Q000187:drug effects*; D018177:Flavivirus Infections / Q000635:transmission / Q000821:virology; D006801:Humans; D017282:Tick-Borne Diseases; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; C000593137:NITD008; D000241:Adenosine
keywords: Antiviral; Flavivirus; NITD008; Nucleoside analog; Tick-borne