title: Osmolarity: A hidden factor in Nanotoxicology.
abstract: In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of long circulating nanocarriers in the blood stream on osmolarity of plasma has not been reported before. In this study, osmotic pressure developed by some commercially available nanocarriers was estimated based on Van't Hoff equation. It is noteworthy that theoretically, nanocarriers do not have any significant effect on osmolarity of plasma. However, it is worth being evaluated experimentally in order to be taken into account in future studies.
authors.affiliation: Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Moayyedi
authors.affiliation: Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Tehran University of Medical Sciences, Lausanne, Switzerland.
authors.forename: Omid
authors.initials: O
authors.lastname: Mashinchian
authors.affiliation: Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. dinarvand@tums.ac.ir.
authors.forename: Rassoul
authors.initials: R
authors.lastname: Dinarvand
mesh_terms: D004337:Drug Carriers / Q000737:chemistry / Q000633:toxicity; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity*; D009997:Osmotic Pressure; D010949:Plasma / Q000502:physiology
chemical_list: D004337:Drug Carriers
keywords: Drug delivery; Nanocarriers; Osmotic pressure