title: Role of reactive oxygen species and TRP channels in the cough reflex.
abstract: The cough reflex is evoked by noxious stimuli in the airways. Although this reflex is essential for health, it can be triggered chronically in inflammatory and infectious airway disease. Neuronal transient receptor potential (TRP) channels such as ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) are polymodal receptors expressed on airway nociceptive afferent nerves. Reactive oxygen species (ROS) and other reactive compounds are associated with inflammation, from either NADPH oxidase or mitochondria. These reactive compounds cause activation and hyperexcitability of nociceptive afferents innervating the airways, and evidence suggests key contributions of TRPA1 and TRPV1.
authors.affiliation: Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA. Electronic address: ttaylorc@health.usf.edu.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Taylor-Clark
mesh_terms: D000818:Animals; D003371:Cough / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000294:innervation / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012018:Reflex / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D050051:Transient Receptor Potential Channels
keywords: Afferent; Airway; Cough; Electrophiles; H(2)O(2); Irritant; Lung; Mitochondria; ROS; Reactive oxygen species; Sensory nerve; TRPA1; TRPV1