title: Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis.
abstract: OBJECTIVE
  Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk.
  
  
  METHODS
  The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity.
  
  
  RESULTS
  A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C.T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers.
  
  
  CONCLUSIONS
  This meta-analysis suggests that OPN rs11730582 C.T polymorphism is not associated with cancer susceptibility.
authors.affiliation: Emergency Department, Zhenjiang First People's Hospital, Zhenjiang, People's Republic of China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Interventional Radiology and Vascular Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
keywords: cancer; osteopontin; polymorphism; risk