title: Techniques and technologies for the bioanalysis of Sativex®, metabolites and related compounds.
abstract: Sativex(®) is an oromucosal spray indicated for the treatment of moderate-to-severe spasticity in multiple sclerosis and is also an effective analgesic for advanced cancer patients. Sativex contains Δ(9)-tetrahydrocannabinol (THC) and cannabidiol in an approximately 1:1 ratio. The increasing prevalence of medicinal cannabis products highlights the importance of reliable bioanalysis and re-evaluation of the interpretation of positive test results for THC, as legal implications may arise in workplace, roadside and sports drug testing situations. This article summarizes published research on the bioanalysis of THC and cannabidiol, with particular focus on Sativex. Common screening and confirmatory testing of blood, urine, oral fluid and hair samples are outlined. Correlations between matrices and current analytical pitfalls are also addressed.
authors.affiliation: Centre for Forensic Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
authors.forename: Anna
authors.initials: A
authors.lastname: Molnar
authors.affiliation: Centre for Forensic Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
authors.forename: Shanlin
authors.initials: S
authors.lastname: Fu
mesh_terms: D000700:Analgesics / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use; D002185:Cannabidiol; D004300:Doping in Sports; D013759:Dronabinol; D004338:Drug Combinations; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy; D010936:Plant Extracts / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use; D017132:Workplace
chemical_list: D000700:Analgesics; D004338:Drug Combinations; D010936:Plant Extracts; D002185:Cannabidiol; D013759:Dronabinol; C587251:nabiximols
keywords: Sativex®; cannabidiol; tetrahydrocannabinol