title: Encapsulation and release studies of strawberry polyphenols in biodegradable chitosan nanoformulation.
abstract: Polyphenols (negative groups) of strawberry extract interacts with positively protonated amino groups of chitosan which helps in maximum encapsulation. This approach can improve the bioavailability and sustained release of phytochemicals having lower bioavailability. The optimum mass ratio of chitosan-tripolyphosphate and polyphenols (PPs) loading was investigated to be 3:1 and 0.5mg/ml of strawberry extract, respectively. Prepared nanoformulation were characterized by UV-vis spectroscopy, Fourier transform infrared spectroscopy and scanning electron microscopy. The formed particles size ranged between 300 and 600nm and polydispersity index (PDI) of≈0.5. The optimized formulation showed encapsulation efficiency of 58.09% at 36.47% of polyphenols loading. Initial burst and continuous release of PPs was observed at pH 7.4 of in vitro release studies. PPs release profile at this pH was found to be non-Fickian analomous diffusion and the release was followed first order kinetics. And at pH 1.4, diffusion-controlled Fickian release of PPs was observed.
authors.affiliation: INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada.
authors.forename: Rama
authors.initials: R
authors.lastname: Pulicharla
authors.affiliation: UEPG, State University of Ponta Grossa, 4748, General Carlos Cavalcante Avenue, Ponta Grossa, PR 84030-900, Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Marques
authors.affiliation: INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada.
authors.forename: Ratul Kumar
authors.initials: RK
authors.lastname: Das
authors.affiliation: INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada.
authors.forename: Tarek
authors.initials: T
authors.lastname: Rouissi
authors.affiliation: INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada. Electronic address: satinder.brar@ete.inrs.ca.
authors.forename: Satinder Kaur
authors.initials: SK
authors.lastname: Brar
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004058:Diffusion; D004339:Drug Compounding; D065546:Drug Liberation; D031985:Fragaria / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry* / Q000302:isolation & purification; D011122:Polyphosphates / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D053769:Nanocapsules; D010936:Plant Extracts; D059808:Polyphenols; D011122:Polyphosphates; D048271:Chitosan; C005692:triphosphoric acid
keywords: Chitosan; Controlled release; Nanoformulation; Polyphenols; Strawberry fruits