title: An enzyme-responsive controlled release system based on a dual-functional peptide.
abstract: A new controlled release system was developed by loading a dual-functional peptide (DFP) on a mesoporous silica material. One-pot synthesis produced a DFP that was stimuli responsive, releasing a therapeutic peptide by protease cleavage. The design provides new steps towards smart biomaterials.
authors.affiliation: Particulate Fluids Processing Centre, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, VIC 3010, Australia. s.gras@unimelb.edu.au.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Burger
authors.forename: A J
authors.initials: AJ
authors.lastname: O'Connor
authors.forename: L
authors.initials: L
authors.lastname: Ong
authors.forename: J A
authors.initials: JA
authors.lastname: Karas
authors.forename: S L
authors.initials: SL
authors.lastname: Gras
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology; D017364:Collagenases / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000378:metabolism; D000521:alpha-MSH / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D000521:alpha-MSH; D012822:Silicon Dioxide; D017364:Collagenases