title: Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC study.
abstract: High blood pressure in middle age (up to 64 years) has been proposed as a predictive indicator of dementia. However, the association between hypertension and the cognitive functioning is controversial in older age groups. The aim of this study was to investigate this association in 70-80-year-old participants in the Japanese study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC). Participants aged 70 (±1) and 80 (±1) years (n=1000 and 973, respectively) were randomly recruited from the general population in Japan. Cognitive functioning was measured by the Montreal Cognitive Assessment. Blood pressure and other medical and social variables were analyzed by multiple regression analyses. High systolic blood pressure (SBP) was significantly correlated with a reduced cognitive functioning only in participants aged 70 years. Additionally, this correlation became more marked in participants with uncontrolled blood pressure at age 70 years. In contrast, SBP was not significantly correlated with the cognitive functioning at age 80 years. Nutritional status indicators such as serum albumin and frequency of going outdoors were significantly associated with cognitive functioning at age 80 years. Our findings indicate that high SBP has a significant role in cognitive functioning at age 70 years; however, blood pressure is less important as a risk factor for cognitive decline at age 80 years.
authors.affiliation: Division of Health Science, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Hirochika
authors.initials: H
authors.lastname: Ryuno
authors.affiliation: Division of Health Science, Osaka University, Graduate School of Medicine, Osaka, Japan.|Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Kamide
authors.affiliation: Department of Clinical Thanatology and Geriatric Behavioral Science, Osaka University Graduate School of Human Sciences, Osaka, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Gondo
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Nakama
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Oguro
authors.affiliation: Division of Health Science, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Kabayama
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kawai
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kusunoki
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Serina
authors.initials: S
authors.lastname: Yokoyama
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Imaizumi
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Takeya
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Takami
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Itoh
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Takeya
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Clinical Thanatology and Geriatric Behavioral Science, Osaka University Graduate School of Human Sciences, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakagawa
authors.affiliation: Department of Prosthodontics, Gerodontology and Oral Rehabilitation, Osaka University Graduate School of Dentistry, Osaka, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ikebe
authors.affiliation: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Inagaki
authors.affiliation: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Masui
authors.affiliation: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishizaki
authors.affiliation: Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Takayama
authors.affiliation: Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Yasumichi
authors.initials: Y
authors.lastname: Arai
authors.affiliation: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Takahashi
authors.affiliation: Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology / Q000523:psychology; D000428:Alcohol Drinking; D003071:Cognition; D004032:Diet; D005260:Female; D006801:Humans; D006973:Hypertension; D007564:Japan; D008297:Male; D012907:Smoking; D016138:Walking