title: Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses.
abstract: Polysaccharides from Ganoderma lucidum (GLPs) have been taken as effective supplements by both healthy people and cancer patients for many years. However, this short survey indicates that instead of inhibiting cancer cell growth, both submerge-cultured intracellular GLP and fruiting body GLP can stimulate the growth of human carcinoma cell lines lacking functional p53, such as HCT-116 p53(-/-), Saos-2, H1299, HL-60, MDA-MB-157. Conversely, the two GLPs inhibit all other assayed cells with functional p53. These results could be an alert since mutational inactivation of the tumor suppressor protein p53 is the most frequent genetic alteration found in human tumors.
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China. ymxia@jiangnan.edu.cn and Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China. ymxia@jiangnan.edu.cn.
authors.forename: Jun-ming
authors.initials: JM
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China. ymxia@jiangnan.edu.cn.
authors.forename: Xiao-xia
authors.initials: XX
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China. ymxia@jiangnan.edu.cn.
authors.forename: Yong-mei
authors.initials: YM
authors.lastname: Xia
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.
authors.forename: Steve W
authors.initials: SW
authors.lastname: Cui
authors.affiliation: Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China. ymxia@jiangnan.edu.cn.
authors.forename: Zhong-yang
authors.initials: ZY
authors.lastname: Ding
mesh_terms: D002273:Carcinogens / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D011134:Polysaccharides / Q000008:administration & dosage*; D020940:Reishi / Q000737:chemistry*; D017384:Sequence Deletion; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins