title: Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs. mutant TERT promoters.
abstract: Transcriptional activation of telomerase reverse transcriptase (TERT) gene is a rate-limiting determinant in the reactivation of telomerase expression in cancers. TERT promoter mutations represent one of the fundamental mechanisms of TERT reactivation in cancer development. We review recent studies that elucidate the molecular mechanisms underscoring activation of mutant TERT promoters.
authors.affiliation: a Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research) , Singapore , Singapore.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research) , Singapore , Singapore.|b Department of Biochemistry , Yong Loo Lin School of Medicine, National University of Singapore (NUS) , Singapore , Singapore.|c Centre for Cancer Biology, University of South Australia and SA Pathology , Adelaide , Australia.
authors.forename: Vinay
authors.initials: V
authors.lastname: Tergaonkar
mesh_terms: D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: C509186:TERT protein, human; D019098:Telomerase