title: Crystal structure of ethyl 3-amino-6-methyl-2-[(4-methyl-phen-yl)carbamo-yl]-4-[(E)-2-phenyl-ethen-yl]thieno[2,3-b]pyridine-5-carboxyl-ate monohydrate.
abstract: In the title mol-ecule, C27H25N3O3S·H2O, the dihedral angle between the planes of the thienyl ring and the pendant p-tolyl group is 39.25 (6)°, while that between the pyridine ring and the pendant phenyl ring is 44.37 (6)°. In addition, there is a slight twist in the bicyclic core, with a dihedral angle of 2.39 (4)° between the thienyl and pyridine rings. The conformation of the carbamoyl moiety is partially determined by an intra-molecular N-H⋯O hydrogen bond. In the crystal, complementary N-H⋯O hydrogen bonds form dimers which are then associated into chains parallel to the c axis through O-H⋯N hydrogen bonds involving the water mol-ecule of crystallization. Electron density associated with an additional solvent mol-ecule of partial occupancy and disordered about a twofold axis was removed with the SQUEEZE procedure in PLATON [Spek (2015 ▸). Acta Cryst. C71, 9-18]. The given chemical formula and other crystal data do not take into account the unknown solvent molecule(s).
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.
authors.forename: Joel T
authors.initials: JT
authors.lastname: Mague
authors.affiliation: Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akkurt
authors.affiliation: Chemistry and Environmental Division, Manchester Metropolitan University, Manchester M1 5GD, England; Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt.
authors.forename: Shaaban K
authors.initials: SK
authors.lastname: Mohamed
authors.affiliation: Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt.
authors.forename: Etify A
authors.initials: EA
authors.lastname: Bakhite
authors.affiliation: Kirkuk University, College of Science, Department of Chemistry, Kirkuk, Iraq.
authors.forename: Mustafa R
authors.initials: MR
authors.lastname: Albayati
keywords: PLATON SQUEEZE; crystal structure; dimer; pyridine ring; thienyl ring