title: Chemical structures of constituents from the whole plant of Bacopa monniera.
abstract: Two new dammarane-type triterpene oligoglycosides, bacomosaponins A and B, and three new phenylethanoid glycosides, bacomosides A, B1, and B2, were isolated from the whole plant of Bacopa monniera Wettst. The chemical structures of the new constituents were characterized on the basis of chemical and physicochemical evidence. In the present study, bacomosaponins A and B with acyl groups were obtained from the whole plant of B. monniera. This is the first report of acylated dammarane-type triterpene oligoglycosides isolated from B. monniera. In addition, dammarane-type triterpene saponins significantly inhibited the aggregation of 42-mer amyloid β-protein.
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Tomoe
authors.initials: T
authors.lastname: Ohta
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.|N.T.H Co., Ltd., 4F Sky-ebisu Bldg., 1-8-11 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan.
authors.forename: Souichi
authors.initials: S
authors.lastname: Nakashima
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.|N.T.H Co., Ltd., 4F Sky-ebisu Bldg., 1-8-11 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Oda
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukaya
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Yano
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan. matsuda@mb.kyoto-phu.ac.jp.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D034681:Bacopa / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*; D000097669:Dammaranes
chemical_list: D010936:Plant Extracts; D014315:Triterpenes; D000097669:Dammaranes
keywords: Ayurvedic traditional medicine; Aβ42 aggregation; Bacomosaponin; Bacomoside; Bacopa monniera