title: Clinical Characteristics of Pediatric-Onset and Adult-Onset Multiple Sclerosis in Hispanic Americans.
abstract: Multiple sclerosis can affect pediatric patients. Our aim was to compare characteristics between pediatric-onset multiple sclerosis and adult-onset multiple sclerosis in Hispanic Americans. This was a cross-sectional analysis of 363 Hispanic American multiple scleroses cases; demographic and clinical characteristics were analyzed. A total of 110 Hispanic patients presented with multiple sclerosis before age 18 and 253 as adult multiple sclerosis. The most common presenting symptoms for both was optic neuritis. Polyfocal symptoms, seizures, and cognitive symptoms at presentation were more prevalent in pediatric-onset multiple sclerosis (P ≤ .001). Transverse myelitis was more frequent in adult-onset multiple sclerosis (P ≤ .001). Using multivariable analysis, pediatric-onset multiple sclerosis (adjusted odds ratio, 0.3OR 95% confidence interval 0.16-0.71, P = .004) and being US born (adjusted odds ratio, 0.553, 95% confidence interval 0.3-1.03, P = .006) were less likely to have severe ambulatory disability. Results suggest that pediatric-onset multiple sclerosis and adult-onset multiple sclerosis in Hispanics have differences that could be important for treatment and prognosis.
authors.affiliation: Division of Neurology, Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California, CA, USA mlangille@chla.usc.edu.
authors.forename: Megan M
authors.initials: MM
authors.lastname: Langille
authors.affiliation: Department of Preventive Medicine, Division of Environmental Health, Keck School of Medicine of University of Southern California, CA, USA.
authors.forename: Talat
authors.initials: T
authors.lastname: Islam
authors.affiliation: Department of Neurology, Division of Immunology and Multiple Sclerosis, Keck School of Medicine of University of Southern California, CA, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Burnett
authors.affiliation: Department of Neurology, Division of Immunology and Multiple Sclerosis, Keck School of Medicine of University of Southern California, CA, USA.
authors.forename: Lilyana
authors.initials: L
authors.lastname: Amezcua
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000208:ethnology* / Q000503:physiopathology*; D015999:Multivariate Analysis; D016017:Odds Ratio; D012042:Registries
keywords: Hispanic American; child neurology; ethnicity; multiple sclerosis; pediatrics