title: Controlled release of a hydrophilic drug from coaxially electrospun polycaprolactone nanofibers.
abstract: A recent approach for controlled release of drugs is the production of core-shell fibers via modified coaxial electrospinning where a shell solution which is not fully electrospinnable can be used. In this study, this technique was used for achieving the controlled release of a model hydrophilic drug (ampicillin) which is known to have a low compatibility with the polymer (polycaprolactone). A partially electrospinnable shell fluid (4% (w/v) polycaprolactone (PCL) solution) and a fully electrospinnable core fluid (10% (w/v) PCL, 2% (w/v) ampicillin solution) were used in order to create ampicillin-loaded PCL nanofibers covered by a PCL shield. Scanning electron microscopy and optical microscopy images proved that the membranes have core-shell structured nanofibers. Fourier transform infrared spectroscopy demonstrated that some compatibility might be present between ampicillin and PCL. Finally, drug release studies showed that the drug release kinetics of core-shell products is closer to zero-order kinetics while the drug release kinetics of single electrospinning of the core resulted with serious burst release. Together, these imply that the application area of modified coaxial electrospinning in controlled release could be expanded to polymers and drugs with low compatibility.
authors.affiliation: Plasma Aided Biomedical Research Group (pabmed), Division of Biomedical Engineering, Institute of Natural and Applied Sciences, TOBB University of Economics and Technology, Ankara, Turkey.
authors.forename: Zahida
authors.initials: Z
authors.lastname: Sultanova
authors.affiliation: Plasma Aided Biomedical Research Group (pabmed), Division of Biomedical Engineering, Institute of Natural and Applied Sciences, TOBB University of Economics and Technology, Ankara, Turkey.
authors.forename: Gizem
authors.initials: G
authors.lastname: Kaleli
authors.affiliation: Plasma Aided Biomedical Research Group (pabmed), Division of Biomedical Engineering, Institute of Natural and Applied Sciences, TOBB University of Economics and Technology, Ankara, Turkey.
authors.forename: Gözde
authors.initials: G
authors.lastname: Kabay
authors.affiliation: Plasma Aided Biomedical Research Group (pabmed), Department of Biomedical Engineering, Faculty of Engineering, TOBB University of Economics and Technology, Ankara, Turkey. Electronic address: m.mutlu@etu.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Mutlu
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D008853:Microscopy; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D000667:Ampicillin
keywords: Ampicillin; Controlled drug release; Core-shell fibers; Modified coaxial electrospinning; Polycaprolactone; Zero order drug release