title: Adenylyl Cyclase-Associated Protein 1 in the Development of Head and Neck Squamous Cell Carcinomas.
abstract: We compared the content of adenylyl cyclase-associated protein 1 (CAP1) in the blood and tissues of patients with head and neck squamous cell carcinomas (with and without regional metastases), patients with chronic inflammatory diseases aggravated by laryngeal and laryngopharyngeal dysplasia, and healthy individuals. The data suggest that serum CAP1 concentration correlated with the depth of primary tumor invasion and the presence of regional metastases. In cancer patients, the serum level of CAP1 was lower than in patients with laryngeal and laryngopharyngeal dysplasia, which can be of importance for differential and timely diagnostics of malignant tumors.
authors.affiliation: Tomsk Cancer Research Institute, Tomsk, Russia. kakurinagv@oncology.tomsk.ru.
authors.forename: G V
authors.initials: GV
authors.lastname: Kakurina
authors.affiliation: Tomsk Cancer Research Institute, Tomsk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Kondakova
authors.affiliation: Tomsk Cancer Research Institute, Tomsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Cheremisina
authors.affiliation: Tomsk Cancer Research Institute, Tomsk, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Shishkin
authors.affiliation: Tomsk Cancer Research Institute, Tomsk, Russia.
authors.forename: E L
authors.initials: EL
authors.lastname: Choinzonov
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000097:blood* / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000097:blood* / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000097:blood / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: C489549:CAP1 protein, human; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins
keywords: actin-binding proteins; adenylyl cyclase-associated protein 1; differential diagnostics; head and neck squamous cell carcinomas; metastasizing