title: A randomized controlled trial of 2 protocols for weaning cardiac surgical patients receiving adaptive support ventilation.
abstract: This study aims to compare the effectiveness of weaning with adaptive support ventilation (ASV) incorporating progressively reduced or constant target minute ventilation in the protocol in postoperative care after cardiac surgery.
  
  
  
  A randomized controlled unblinded study of 52 patients after elective coronary artery bypass surgery was carried out to determine whether a protocol incorporating a decremental target minute ventilation (DTMV) results in more rapid weaning of patients ventilated in ASV mode compared to a protocol incorporating a constant target minute ventilation.
  
  
  
  Median duration of mechanical ventilation (145 vs 309 minutes; P = .001) and intubation (225 vs 423 minutes; P = .005) were significantly shorter in the DTMV group. There was no difference in adverse effects (42% vs 46%) or mortality (0% vs 0%) between the 2 groups.
  
  
  
  Use of a DTMV protocol for postoperative ventilation of cardiac surgical patients in ASV mode results in a shorter duration of ventilation and intubation without evidence of increased risk of adverse effects.
authors.affiliation: Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: M K P
authors.initials: MK
authors.lastname: Tam
authors.affiliation: Department of Anaesthesia & Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: W T
authors.initials: WT
authors.lastname: Wong
authors.affiliation: Department of Anaesthesia & Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong. Electronic address: gomersall@cuhk.edu.hk.
authors.forename: C D
authors.initials: CD
authors.lastname: Gomersall
authors.affiliation: Department of Anaesthesia & Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Q
authors.initials: Q
authors.lastname: Tian
authors.affiliation: Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: S K
authors.initials: SK
authors.lastname: Ng
authors.affiliation: Department of Anaesthesia & Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: C C H
authors.initials: CC
authors.lastname: Leung
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: M J
authors.initials: MJ
authors.lastname: Underwood
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D012121:Respiration, Artificial; D013997:Time Factors; D016896:Treatment Outcome; D015300:Ventilator Weaning / Q000379:methods*
keywords: Adult; Coronary artery bypass; Critical care; Morbidity; Respiration, Artificial; Ventilator weaning