title: Dearomatization of Electron-Deficient Nitrogen Heterocycles via Cobalt-Catalyzed Asymmetric Cyclopropanation.
abstract: The dearomatization of a series of electron-deficient nitrogen heterocycles has been achieved through a cobalt-catalyzed asymmetric cyclopropanation reaction. This reaction proceeds with high levels of enantio- and diastereoselectivity to afford unique cyclopropanes that can be further functionalized to provide complex heterocyclic building blocks.
authors.affiliation: Department of Process & Analytical Chemistry, Merck & Co., Inc. P.O. Box 2000, Rahway, New Jersey 07065, United States.
authors.forename: Amruta
authors.initials: A
authors.lastname: Joshi-Pangu
authors.affiliation: Department of Process & Analytical Chemistry, Merck & Co., Inc. P.O. Box 2000, Rahway, New Jersey 07065, United States.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Cohen
authors.affiliation: Department of Process & Analytical Chemistry, Merck & Co., Inc. P.O. Box 2000, Rahway, New Jersey 07065, United States.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Tudge
authors.affiliation: Department of Process & Analytical Chemistry, Merck & Co., Inc. P.O. Box 2000, Rahway, New Jersey 07065, United States.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Chen