title: Long-Term Survival, Quality of Life, and Quality-Adjusted Survival in Critically Ill Patients With Cancer.
abstract: To assess the long-term survival, health-related quality of life, and quality-adjusted life years of cancer patients admitted to ICUs.
  
  
  
  Prospective cohort.
  
  
  
  Two cancer specialized ICUs in Brazil.
  
  
  
  A total of 792 participants.
  
  
  
  None.
  
  
  
  The health-related quality of life before ICU admission; at 15 days; and at 3, 6, 12, and 18 months was assessed with the EQ-5D-3L. In addition, the vital status was assessed at 24 months. The mean age of the subjects was 61.6 ± 14.3 years, 42.5% were female subjects and half were admitted after elective surgery. The mean Simplified Acute Physiology Score 3 was 47.4 ± 15.6. Survival at 12 and 18 months was 42.4% and 38.1%, respectively. The mean EQ-5D-3L utility measure before admission to the ICU was 0.47 ± 0.43, at 15 days it was 0.41 ± 0.44, at 90 days 0.56 ± 0.42, at 6 months 0.60 ± 0.41, at 12 months 0.67 ± 0.35, and at 18 months 0.67 ± 0.35. The probabilities for attaining 12 and 18 months of quality-adjusted survival were 30.1% and 19.1%, respectively. There were statistically significant differences in survival time and quality-adjusted life years according to all assessed baseline characteristics (ICU admission after elective surgery, emergency surgery, or medical admission; Simplified Acute Physiology Score 3; cancer extension; cancer status; previous surgery; previous chemotherapy; previous radiotherapy; performance status; and previous health-related quality of life). Only the previous health-related quality of life and performance status were associated with the health-related quality of life during the 18-month follow-up.
  
  
  
  Long-term survival, health-related quality of life, and quality-adjusted life year expectancy of cancer patients admitted to the ICU are limited. Nevertheless, these clinical outcomes exhibit wide variability among patients and are associated with simple characteristics present at the time of ICU admission, which may help healthcare professionals estimate patients' prognoses.
authors.affiliation: 1Heart Hospital (Hospital do Coração-HCor), Research Institute-São Paulo, São Paulo, Brazil. 2Department of Preventive Medicine, School of Medicine, University of São Paulo (Faculdade de Medicina da Universidade de São Paulo-FMUSP)-São Paulo, São Paulo, Brazil. 3Cancer Institute of the State of São Paulo (Instituto do Câncer do Estado de São Paulo-ICESP)-São Paulo, São Paulo, Brazil. 4Institute of Mathematics and Statistics, University of São Paulo (Instituto de Matemática e Estatística da Universidade de São Paulo-IME-USP)-São Paulo, São Paulo, Brazil. 5Foundation Pio XII Barretos Cancer Hospital (Hospital do Câncer de Barretos)-Barretos, São Paulo, Brazil.
authors.forename: Karina
authors.initials: K
authors.lastname: Normilio-Silva
authors.forename: Adelaide Cristina
authors.initials: AC
authors.lastname: de Figueiredo
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Pedroso-de-Lima
authors.forename: Gisela
authors.initials: G
authors.lastname: Tunes-da-Silva
authors.forename: Adriana
authors.initials: A
authors.lastname: Nunes da Silva
authors.forename: Andresa
authors.initials: A
authors.lastname: Delgado Dias Levites
authors.forename: Ana Tereza
authors.initials: AT
authors.lastname: de-Simone
authors.forename: Patrícia
authors.initials: P
authors.lastname: Lopes Safra
authors.forename: Roberta
authors.initials: R
authors.lastname: Zancani
authors.forename: Paula Camilla
authors.initials: PC
authors.lastname: Tonini
authors.forename: Ulysses
authors.initials: U
authors.lastname: Vasconcelos de Andrade E Silva
authors.forename: Thiago
authors.initials: T
authors.lastname: Buosi Silva
authors.forename: Juliana
authors.initials: J
authors.lastname: Martins Giorgi
authors.forename: José
authors.initials: J
authors.lastname: Eluf-Neto
authors.forename: Anderson
authors.initials: A
authors.lastname: Costa
authors.forename: Ludhmila
authors.initials: L
authors.lastname: Abrahão Hajjar
authors.forename: Alexandre
authors.initials: A
authors.lastname: Biasi Cavalcanti
mesh_terms: D000368:Aged; D001938:Brazil / Q000453:epidemiology; D016638:Critical Illness / Q000401:mortality; D005260:Female; D006304:Health Status; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality; D010343:Patient Admission; D011446:Prospective Studies; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D016019:Survival Analysis