title: Rational design of multifunctional small-molecule prodrugs for simultaneous suppression of cancer cell growth and metastasis in vitro and in vivo.
abstract: We present a design concept for multifunctional prodrugs that simultaneously induce apoptosis and suppress cancer cell metastasis in vitro and in vivo. These "all-in-one" prodrug constructs possess therapeutic potential as novel "integrative" platforms for metastatic cancer treatment.
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Xie
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Chen
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Lingling
authors.initials: L
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Jinhua People's Hospital, Jinhua, Zhejiang Province 321000, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Fang
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Hangxiang
authors.initials: H
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Shusen
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation; D006801:Humans; D066298:In Vitro Techniques; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs