title: Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3.
abstract: Bcl-3 is a member of the IκB family of proteins and an important regulator of Nuclear Factor (NF)-κB activity. The ability of Bcl-3 to bind and regulate specific NF-κB dimers has been studied in great depth, but its physiological roles in vivo are still not fully understood. It is, however, becoming clear that Bcl-3 is essential for the proper development, survival and activity of adaptive immune cells. Bcl-3 dysregulation can be observed in a number of autoimmune pathologies, and Bcl3-deficient animals are more susceptible to bacterial and parasitic infection. This review will describe our current understanding of the roles played by Bcl-3 in the development and regulation of the adaptive immune response, including lymphoid organogenesis, immune tolerance, lymphocyte function and dendritic cell biology.
authors.affiliation: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, Scotland, UK. Felicity.Herrington@glasgow.ac.uk.
authors.forename: Felicity D
authors.initials: FD
authors.lastname: Herrington
authors.affiliation: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, Scotland, UK. Robert.Nibbs@glasgow.ac.uk.
authors.forename: Robert J B
authors.initials: RJ
authors.lastname: Nibbs
keywords: Bcl-3; NF-κB; adaptive immunity; inflammation