title: Characteristics of breast cancer in Central China, literature review and comparison with USA.
abstract: BACKGROUND
  This work was to analyze characteristics of breast cancer (BC) in Central China, summarize main characteristics in China and compare with USA.
  
  
  METHODS
  BC main characteristics from four hospitals in Central China from 2002 to 2012 were collected and analyzed. All the single and large-scale clinical reports covering at least ten years were selected and summarized to calculate the BC characteristics of China. BC Characteristics in USA were selected based on the database from Surveillance, Epidemiology, and End Results (SEER) Program.
  
  
  RESULTS
  Age distribution in Central China was normal with one age peak at 45-49 years, displaying differences from USA and Chinese American with two age peaks. BC characteristics in Central China displayed distinct features from USA and Chinese American, including significant younger onset age, lower proportion of patients with stage I, lymph node negative, small tumor size and ER positive. A total ten long-term and large-scale clinical reports were selected for BC characteristics of Mainland China analysis. A total of 53,571 BC patients were enrolled from 1995 to 2012. The main characteristics of BC in Mainland China were similar as that in Central China, but were significant different from developed regions of China (Hong Kong and Taiwan), USA and Chinese American.
  
  
  CONCLUSIONS
  BC characteristics in Central China displayed representative patterns of Mainland China, while showed distinct patterns from Chinese patients in other developed areas and USA.
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Chuang
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory Medicine Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Si
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Yuan
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Yao-Huai
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Tian-Ze
authors.initials: TZ
authors.lastname: Cao
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China; Department of Breast Surgery, Hubei Cancer Hospital, Wuhan, Hubei 430079, PR China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Zheng
authors.affiliation: Department of Breast and Thyroid Surgery, The Central Hospital of Wuhan, Wuhan, Hubei 430014, PR China.
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Jiang
authors.affiliation: Department of Breast Surgery, Hubei Cancer Hospital, Wuhan, Hubei 430079, PR China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Gong
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yao
authors.affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, PR China.
authors.forename: Ming-Bai
authors.initials: MB
authors.lastname: Hu
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Li
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
authors.forename: Sheng-Rong
authors.initials: SR
authors.lastname: Sun
authors.affiliation: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China. Electronic address: 99161305@qq.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001213:Asian / Q000706:statistics & numerical data; D001943:Breast Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D002681:China / Q000453:epidemiology; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000378:metabolism; D018426:SEER Program; D013624:Taiwan / Q000453:epidemiology; D047368:Tumor Burden; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen
keywords: Breast cancer; Chinese patient; Clinico-pathological characteristics; Mainland China; Median age