title: Sudden cardiac death markers in non-ischemic cardiomyopathy.
abstract: Heart failure is an increasingly prevalent disease associated with high morbidity and mortality. In 30-40% of patients, the etiology is non-ischemic. In this group of patients, the implantable cardioverter-defibrillator (ICD) prevents sudden death and decreases total mortality. However, due to burden of cost, the fact that many ICD patients will never need any therapy, and possible complications involved in implant and follow-up, the device should not be implanted in every patient with non-ischemic heart failure. There is an urgent need to adequately identify patients with highest sudden death risk, in whom the implant is most cost-effective. In the present paper, the authors discuss current available tests for risk stratification of sudden cardiac death in patients with non-ischemic heart failure.
authors.affiliation: Cardiac Electrophysiology Group, Hospital de Clinicas de Porto Alegre; Post-Graduate Program in Cardiology and Cardiovacular Sciences, Universidade Federal do Rio Grande do Sul.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Pimentel
authors.affiliation: Heart Failure and Transplant Group, Cardiology Division, Hospital de Clinicas de Porto Alegre; Post-Graduate Program in Cardiology and Cardiovacular Sciences, Universidade Federal do Rio Grande do Sul; Medical School, Universidade Federal do Rio Grande do Sul.
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Rohde
authors.affiliation: Medical School, Universidade Federal do Rio Grande do Sul.
authors.forename: André
authors.initials: A
authors.lastname: Zimerman
authors.affiliation: Cardiac Electrophysiology Group, Hospital de Clinicas de Porto Alegre; Post-Graduate Program in Cardiology and Cardiovacular Sciences, Universidade Federal do Rio Grande do Sul; Medical School, Universidade Federal do Rio Grande do Sul. Electronic address: zimerman@cardiol.br.
authors.forename: Leandro Ioschpe
authors.initials: LI
authors.lastname: Zimerman
mesh_terms: D000465:Algorithms; D015415:Biomarkers; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000517:prevention & control*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D019317:Evidence-Based Medicine; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods; D006334:Heart Function Tests / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D005819:Genetic Markers
keywords: Non-Ischemic Cardiomyopathy; Risk stratification; Sudden death