title: Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer.
abstract: A complete understanding of the natural history of infection with high-risk human papillomaviruses (HPVs) in cervical cancer requires data from regional and ethnic studies. The prevalence of high-risk HPVs was evaluated retrospectively in 2040 patients with cervicitis, 239 with cervical intraepithelial neoplasia grade 1 (CIN1), 242 with CIN2/3, and 42 patients with invasive squamous cell carcinoma (SCC) based on data from patients who visited our hospital between May 2013 and May 2015. The rates of high-risk HPV infection in patients with cervicitis, CIN1, CIN2/3, and invasive SCC were 40.8%, 74.9%, 70.2%, and 83.3%, respectively. The three most dominant HPV genotypes were HPV16, 58, and 52. HPV16 and HPV58 positivity in cervicitis, CIN1, CIN2/3, and SCC patients were 20.9% and 16.4%, 19.0% and 20.1%, 44.1% and 23.5%, and 60.0% and 31.4%, respectively. Compared to cervicitis, the odds ratios (ORs) for CIN2/3 in HPV16- and HPV58-positive patients were 2.99 (95% confidence interval [CI]: 1.32-4.33) and 1.56 (1.11-3.21), respectively; for SCC, the corresponding values were 5.68 (2.31-7.893) and 2.33 (1.41-3.87). Further identifying of carcinogenic HPVs and a fully aware of regional differences in HPV genotype distribution are tasks of top priority for cervical cancer control and prevention.
authors.affiliation: Department of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Clinical Laboratory, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China.
authors.forename: Chenyun
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Pathology, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Zou
authors.affiliation: Department of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000821:virology; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*
keywords: cervical intraepithelial neoplasia grade 1 to 3; cervicitis; high-risk human papillomaviruses; invasive squamous cell carcinoma