title: [Anesthetic Management for Lobectomy in a Patient with Pulmonary Arterial Hypertension].
abstract: Pulmonary arterial hypertension (PAH) is a known risk factor of perioperative complications, but the risks for non-cardiac operations have not yet been examined sufficiently. We report a case of a right lower lobectomy in a patient with PAH. A 73-year-old woman with Sjögren's syndrome was scheduled for right lowr lobectomy for primary lung cancer under general anesthesia. She was diagnosed with symptomatic PAH (estimated mean pulmonary arterial pressure, 40 mmHg) and medicated with ambrisentan. After induction of general anesthesia with propofol and fentanyl, a pulmonary artery catheter was placed to measure pulmonary artery pressure. The Pp/Ps was roughly 0.4 and the pulmonary artery clamp elevated it to 0.5. Milrinone administration gradually improved the Pp/Ps to 0.3. To avoid pulmonary artery pressure elevation during emergence of anesthesia, continuous dexmedetomidine was administered. The double-lumen tracheal tube was extubated uneventfully with minimal elevation in pulmonary arterial pressure.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Imajo
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Komasawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kusaka
authors.forename: Haruki
authors.initials: H
authors.lastname: Kido
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Minami
mesh_terms: D000368:Aged; D000758:Anesthesia / Q000379:methods*; D020927:Dexmedetomidine / Q000627:therapeutic use; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000601:surgery*; D010666:Phenylpropionates / Q000627:therapeutic use; D011013:Pneumonectomy / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage; D011724:Pyridazines / Q000627:therapeutic use
chemical_list: D010666:Phenylpropionates; D011724:Pyridazines; D020927:Dexmedetomidine; C467894:ambrisentan; D005283:Fentanyl; D015742:Propofol