title: Age and gender specific estimation of visceral adipose tissue amounts from radiological images in morbidly obese patients.
abstract: Image-based quantifications of visceral adipose tissue (VAT) volumes from segmented VAT areas are increasingly considered for risk assessment in obese patients. The goal of this study was to determine the power of partial VAT areas to predict total VAT volume in morbidly obese patients (BMI > 40 kg/m(2)) as a function of gender, age and anatomical landmarks. 130 morbidly obese patients (mean BMI 46.5 kg/m(2); 94 females) underwent IRB-approved MRI. Total VAT volumes were predicted from segmented VAT areas (of single or five adjacent slices) at common axial landmark levels and compared with the measured ones (VVAT-T, about 40 slices between diaphragm and pelvic floor). Standard deviations σ1 and σ5 of the respective VAT volume differences served as measures of agreement. Mean VVAT-T was 4.9 L for females and 8.1 L for males. Best predictions were found at intervertebral spaces L3-L4 for females (σ5 = 688 ml, σ1 = 832 ml) and L1-L2 for males (σ5 = 846 ml, σ1 = 992 ml), irrespective of age. In conclusion, VAT volumes in morbidly obese patients can be reliably predicted by multiplying the segmented VAT area at a gender-specific lumbar reference level with a fixed scaling factor and effective slice thickness.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, Leipzig, Germany.|Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Linder
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, Leipzig, Germany.|Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schaudinn
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, Leipzig, Germany.|Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
authors.forename: Nikita
authors.initials: N
authors.lastname: Garnov
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.|Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology and Nephrology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Blüher
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.|Department of Visceral, Transplantation, Thoracic and Vascular Surgery, Division of Bariatric Surgery, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Dietrich
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.|Department of Visceral, Transplantation, Thoracic and Vascular Surgery, Division of Bariatric Surgery, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Schütz
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Lehmann
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
authors.forename: Ulf
authors.initials: U
authors.lastname: Retschlag
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.|Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Karlas
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, Leipzig, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kahn
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, Leipzig, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Busse
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000000981:diagnostic imaging*; D012044:Regression Analysis; D012737:Sex Factors; D055815:Young Adult