title: Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium.
abstract: Thousands of ostensibly healthy individuals have had their exome or genome sequenced, but a much smaller number of these individuals have received any personal genomic results from that sequencing. We term those projects in which ostensibly healthy participants can receive sequencing-derived genetic findings and may also have access to their genomic data as participatory predispositional personal genome sequencing (PPGS). Here we are focused on genome sequencing applied in a pre-symptomatic context and so define PPGS to exclude diagnostic genome sequencing intended to identify the molecular cause of suspected or diagnosed genetic disease. In this report we describe the design of completed and underway PPGS projects, briefly summarize the results reported to date and introduce the PeopleSeq Consortium, a newly formed collaboration of PPGS projects designed to collect much-needed longitudinal outcome data.
authors.affiliation: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. michael.linderman@mssm.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Linderman
authors.affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. dnielsen@genetics.med.harvard.edu.|Harvard Medical School, Boston, MA 02115, USA. dnielsen@genetics.med.harvard.edu.|Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. dnielsen@genetics.med.harvard.edu.
authors.forename: Daiva E
authors.initials: DE
authors.lastname: Nielsen
authors.affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. rcgreen@genetics.med.harvard.edu.|Harvard Medical School, Boston, MA 02115, USA. rcgreen@genetics.med.harvard.edu.|Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. rcgreen@genetics.med.harvard.edu.|Partners Personalized Medicine, Cambridge, MA 02139, USA. rcgreen@genetics.med.harvard.edu.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Green
keywords: genomics; personal genome sequencing; population screening; return of results