title: The Association Between Serum Procalcitonin Levels and Severity of Coronary Artery Disease Assessed by SYNTAX Score in Patients With Acute Coronary Syndrome.
abstract: The SYNTAX score (SX score) is a useful score for assessing the severity of coronary artery disease (CAD). Previous studies have demonstrated a close relationship between SX score and inflammation. Procalcitonin (PCT) is an early inflammatory marker, especially during sepsis. Thus, in this study, we aimed to investigate the relationship between SX score and serum PCT levels. A total of 545 patients were enrolled in this prospective cross-sectional study and were divided into 2 subgroups, according to their SX score. Serum PCT and high-sensitivity C-reactive protein levels were measured. Serum PCT levels were higher in the high SX score group compared to the low-intermediate SX score group (P < .001). Serum PCT levels were an independent predictor of a high SX score in patients with acute coronary syndrome (P = .001). As patients with a higher SX score had increased serum PCT levels on admission, serum PCT may be useful for identifying patients with severe CAD.
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet Göktuğ
authors.initials: AG
authors.lastname: Ertem
authors.affiliation: Department of Cardiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Tolga Han
authors.initials: TH
authors.lastname: Efe
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey cagriyayla@gmail.com.
authors.forename: Çağrı
authors.initials: Ç
authors.lastname: Yayla
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboğa
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Açar
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Ünal
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kirbaş
authors.affiliation: Department of Infectious Disease, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Sezer Tekce
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Maden
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Selcuk
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Timur
authors.initials: MT
authors.lastname: Selcuk
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002116:Calcitonin / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018805:Sepsis / Q000097:blood / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D002116:Calcitonin
keywords: SYNTAX score; atherosclerosis; coronary artery disease; inflammation; procalcitonin