title: Early respiratory infections: the role of passive smoking in gene-environment interaction.
abstract: This study aims to: (i) estimate genetic and environmental components of four early respiratory diseases and (ii) test if these components are modified by parental smoking exposure. Study subjects were 2068 Italian twins aged 3-17. We performed biometric modeling under the assumptions of the twin design. For bronchitis and bronchiolitis, variance was mostly explained by shared environment, with no modification effect by parental smoking. For pneumonia and wheezy bronchitis, shared environmental component was larger among passive smokers, while genetic component was predominant among non-smokers. In the etiology of pneumonia and wheezy bronchitis, parental smoking could be a major familial factor.
authors.affiliation: 1 Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità, Rome, Italy 2 Università Bocconi, CERGAS (Centre for Research on Health and Social Care Management), Milano, Lombardia, Italy sonia.brescianini@iss.it.
authors.forename: Sonia
authors.initials: S
authors.lastname: Brescianini
authors.affiliation: 1 Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Fagnani
authors.affiliation: 3 Istituto Nazionale di Statistica, Rome, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Aquilini
authors.affiliation: 4 Epidémiologie des Maladies Allergiques e Respiratoires (EPAR) Department INSERM & UPMC Paris 6, Paris, France.
authors.forename: Isabella
authors.initials: I
authors.lastname: Annesi-Maesano
authors.affiliation: 1 Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Stazi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D010290:Parents; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000235:genetics; D014028:Tobacco Smoke Pollution / Q000706:statistics & numerical data*; D014427:Twins / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: D014028:Tobacco Smoke Pollution