title: The importance of surgical margins in prostate cancer.
abstract: Positive surgical margins (PSM) after radical prostatectomy (RP) are a predictor of biochemical recurrence (BCR), and highly dependent on surgeon, experience, and skill. The length and location PSMs are important, with significant differences between open and robotic RP. The impact of PSMs on BCR remains secondary to other clinico-pathologic variables: Gleason Score, pathologic stage, and baseline PSA. However, lower PSM rates are associated with reduced use of secondary interventions and patient anxiety of cancer recurrence.
authors.affiliation: Department of Urology, University of Oxford, Oxford, United Kingdom.
authors.forename: Prasanna
authors.initials: P
authors.lastname: Sooriakumaran
authors.affiliation: Department of Urology, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Harveer S
authors.initials: HS
authors.lastname: Dev
authors.affiliation: Department of Urology, University of California, Irvine, California.
authors.forename: Douglas
authors.initials: D
authors.lastname: Skarecky
authors.affiliation: Department of Urology, University of California, Irvine, California.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ahlering
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000517:prevention & control*; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000517:prevention & control; D011237:Predictive Value of Tests; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000379:methods* / Q000592:standards*; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D012307:Risk Factors; D065287:Robotic Surgical Procedures
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen
keywords: biochemical recurrence; positive surgical margins; prostate cancer; radical prostatectomy; robotic