title: Ruthenium-Catalyzed Hydroarylation and One-Pot Twofold Unsymmetrical C-H Functionalization of Arenes.
abstract: A methyl phenyl sulfoximine (MPS) is used as a directing group in the ruthenium-catalyzed intramolecular hydroarylation of alkene-tethered benzoic acid derivatives to afford dihydrobenzofurans and indolines in good to excellent yields. A one-pot, unsymmetrical, twofold C-H functionalization involving intramolecular C-C and intermolecular C-C/C-N bond formations is successfully demonstrated by using a single set of catalytic reaction conditions, which is unprecedented thus far. A novel isoquinolone-bearing dihydrobenzofuran is constructed through an unsymmetrical twofold C-H functionalization.
authors.affiliation: School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad, Telangana, 500046, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad, Telangana, 500046, India.
authors.forename: Raja K
authors.initials: RK
authors.lastname: Rit
authors.affiliation: School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad, Telangana, 500046, India.
authors.forename: E
authors.initials: E
authors.lastname: Ramesh
authors.affiliation: School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad, Telangana, 500046, India. akhilchemistry12@gmail.com.
authors.forename: Akhila K
authors.initials: AK
authors.lastname: Sahoo
keywords: C−H activation; annulations; heterocycles; reaction mechanisms; ruthenium