title: Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity.
abstract: Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma.
  
  
  
  The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune-stain positivity conclusively established the diagnosis of NUT midline carcinoma.
  
  
  
  Absence of well-known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis. © 2016 Wiley Periodicals, Inc. Head Neck 38:E2471-E2474, 2016.
authors.affiliation: Division of Hematology and Oncology, Brookdale University Hospital and Medical Center, Brooklyn, New York.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kundra
authors.affiliation: Division of Hematology and Oncology, Brookdale University Hospital and Medical Center, Brooklyn, New York.
authors.forename: Mirela
authors.initials: M
authors.lastname: Andrei
authors.affiliation: Division of Pathology, Oncology, and Otolaryngology/Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
authors.forename: William
authors.initials: W
authors.lastname: Westra
authors.affiliation: Division of Otolaryngology/Head and Neck Surgery, Brookdale University Hospital and Medical Center, Brooklyn, New York.
authors.forename: Rashid
authors.initials: R
authors.lastname: Chaudhry
authors.affiliation: Division of Pathology, Brookdale University Hospital and Medical Center, Brooklyn, New York.
authors.forename: Harry
authors.initials: H
authors.lastname: Moussouris
authors.affiliation: Division of Radiology, Brookdale University Hospital and Medical Center, Brooklyn, New York.
authors.forename: Arash
authors.initials: A
authors.lastname: Gohari
authors.affiliation: Division of Hematology and Oncology, Brookdale University Hospital and Medical Center, Brooklyn, New York.
authors.forename: Jen C
authors.initials: JC
authors.lastname: Wang
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009363:Neoplasm Proteins; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D035583:Rare Diseases; D014057:Tomography, X-Ray Computed
chemical_list: C000630260:NUTM1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins
keywords: laryngeal carcinoma; nuclear protein in testis (NUT) midline carcinoma