title: Femtosecond lasers for laser in situ keratomileusis: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to review and meta-analyze whether there are differences between reported femtosecond (FS) lasers for laser-assisted in situ keratomileusis (LASIK) in terms of efficacy, predictability, and safety as primary outcomes and corneal flap thickness measurements and pre- and postoperative complications as secondary outcomes.
  
  
  METHODS
  A comprehensive literature search of PubMed, Science Direct, Scopus, and Cochrane CENTRAL Trials Library databases was conducted to identify the relevant prospective randomized controlled trials of FS lasers for LASIK. Thirty-one articles describing a total of 5,404 eyes were included.
  
  
  RESULTS
  Based on efficacy, IntraLase FS 10 and 30 kHz gave the best results. Based on predictability and safety, there were no differences between various FS lasers. FEMTO LDV and IntraLase FS 60 kHz produced the most accurate flap thicknesses. IntraLase and Wavelight SF200 had the fewest intraoperative complications. IntraLase, Visumax, and Wavelight FS200 had the most seldom postoperative complications.
  
  
  CONCLUSIONS
  There were dissimilarities between different FS lasers based on efficacy and intraoperative and postoperative complications. All FS lasers were predictable and safe for making corneal flaps in LASIK.
authors.affiliation: Silmäasema Eye Hospital, School of Medicine, School of Medicine, University of Tampere, Tampere, Finland.
authors.forename: Anne
authors.initials: A
authors.lastname: Huhtala
authors.affiliation: Silmäasema Eye Hospital, School of Medicine, School of Medicine, University of Tampere, Tampere, Finland; SILK, Department of Ophthalmology, School of Medicine, University of Tampere, Tampere, Finland.
authors.forename: Juhani
authors.initials: J
authors.lastname: Pietilä
authors.affiliation: Silmäasema Eye Hospital, School of Medicine, School of Medicine, University of Tampere, Tampere, Finland; SILK, Department of Ophthalmology, School of Medicine, University of Tampere, Tampere, Finland.
authors.forename: Petri
authors.initials: P
authors.lastname: Mäkinen
authors.affiliation: Silmäasema Eye Hospital, School of Medicine, School of Medicine, University of Tampere, Tampere, Finland; SILK, Department of Ophthalmology, School of Medicine, University of Tampere, Tampere, Finland; TAUH Eye Center, Tampere University Hospital, Tampere, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Uusitalo
keywords: LASIK; femtosecond laser; laser in situ keratomileusis; meta-analysis