title: Distinct neural substrates of affective and cognitive theory of mind impairment in semantic dementia.
abstract: Using structural MRI, we investigated the brain substrates of both affective and cognitive theory of mind (ToM) in 19 patients with semantic dementia. We also ran intrinsic connectivity analyses to identify the networks to which the substrates belong and whether they are functionally disturbed in semantic dementia. In line with previous studies, we observed a ToM impairment in patients with semantic dementia even when semantic memory was regressed out. Our results also highlighted different neural bases according to the nature (affective or cognitive) of the representations being inferred. The affective ToM deficit was associated with atrophy in the amygdala, suggesting the involvement of emotion-processing deficits in this impairment. By contrast, cognitive ToM performances were correlated with the volume of medial prefrontal and parietal regions, as well as the right frontal operculum. Intrinsic connectivity analyses revealed decreased functional connectivity, mainly between midline cortical regions and temporal regions. They also showed that left medial temporal regions were functionally isolated, a further possible hindrance to normal social cognitive functioning in semantic dementia. Overall, this study addressed for the first time the neuroanatomical substrates of both cognitive and affective ToM disruption in semantic dementia, highlighting disturbed connectivity within the networks that sustain these abilities.
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bejanin
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Chételat
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Laisney
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.|e Neurology Department , Caen University Hospital , Caen , France.
authors.forename: Alice
authors.initials: A
authors.lastname: Pélerin
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Landeau
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|f Neurology Department , Pontchaillou University Hospital , Rennes , France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Merck
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|f Neurology Department , Pontchaillou University Hospital , Rennes , France.
authors.forename: Serge
authors.initials: S
authors.lastname: Belliard
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.|e Neurology Department , Caen University Hospital , Caen , France.
authors.forename: Vincent
authors.initials: V
authors.lastname: de La Sayette
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.
authors.forename: Francis
authors.initials: F
authors.lastname: Eustache
authors.affiliation: a U1077, INSERM , Caen , France.|b UMR-S1077, University of Caen Normandy , Caen , France.|c UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France.|d U1077, Caen University Hospital , Caen , France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Desgranges
mesh_terms: D000339:Affect / Q000502:physiology; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009483:Neuropsychological Tests; D009929:Organ Size; D012146:Rest; D012938:Social Perception; D056345:Theory of Mind / Q000502:physiology
keywords: Frontotemporal dementia; functional neuroimaging; semantic dementia; social cognition; theory of mind