title: Accelerated Discovery in Photocatalysis using a Mechanism-Based Screening Method.
abstract: Herein, we report a conceptually novel mechanism-based screening approach to accelerate discovery in photocatalysis. In contrast to most screening methods, which consider reactions as discrete entities, this approach instead focuses on a single constituent mechanistic step of a catalytic reaction. Using luminescence spectroscopy to investigate the key quenching step in photocatalytic reactions, an initial screen of 100 compounds led to the discovery of two promising substrate classes. Moreover, a second, more focused screen provided mechanistic insights useful in developing proof-of-concept reactions. Overall, this fast and straightforward approach both facilitated the discovery and aided the development of new light-promoted reactions and suggests that mechanism-based screening strategies could become useful tools in the hunt for new reactivity.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Hopkinson
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
authors.forename: Adrián
authors.initials: A
authors.lastname: Gómez-Suárez
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Teders
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
authors.forename: Basudev
authors.initials: B
authors.lastname: Sahoo
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany. glorius@uni-muenster.de.
authors.forename: Frank
authors.identifier: http://orcid.org/0000-0002-0648-956X
authors.initials: F
authors.lastname: Glorius
keywords: benzotriazoles; luminescence; phenols; photocatalysis; screening