title: New Findings in Diabetic Maculopathy and Proliferative Disease by Swept-Source Optical Coherence Tomography Angiography.
abstract: OBJECTIVE
  To describe the optical coherence tomography (OCT) angiography (OCTA) features of diabetic retinopathy.
  
  
  METHODS
  Retrospective serial case reports were examined of patients who underwent routine clinical examination and OCTA with both DRI OCT Atlantis prototype and Triton Swept-Source OCT of the posterior pole and mid-periphery. When considered necessary, fluorescein fundus angiography (FFA) with OPTOS California wide-field imaging was performed. The findings were compared with the current literature.
  
  
  RESULTS
  Forty-three consecutive patients (86 eyes) were evaluated. Fourteen of these patients (28 eyes) underwent an additional FFA examination due to advanced retinopathy signs, such as diabetic macular edema, ischemia or neovascularization (NV). OCTA was able to detect the microvascular lesions observed on color fundus images in the whole sample. Thirty-six of the 86 eyes showed foveal avascular zone enlargement on OCTA. Microvascular lesions, diabetic macular edema, and NV of the optic disc observed on FFA were also detected on OCTA in all cases (28/28 eyes). Features of NV elsewhere were detected on FFA in 16/28 eyes. Ten of the 16 eyes had signs of NV within the 100 central degrees, and OCTA was able to detect these signs in 9 of the eyes.
  
  
  CONCLUSIONS
  OCTA is an effective noninvasive imaging technique that can provide additional information regarding the localization and morphology of vascular lesions in all cases of NV of the optic disc and in more than half of cases of NV elsewhere, suggesting that it is a noninferior technique for the study of posterior pole alterations compared with FFA, which remains the gold standard and is fundamental for the study of the retinal periphery.
authors.forename: Paulo E
authors.initials: PE
authors.lastname: Stanga
authors.forename: Alessandro
authors.initials: A
authors.lastname: Papayannis
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Tsamis
authors.forename: Francesco
authors.initials: F
authors.lastname: Stringa
authors.forename: Tim
authors.initials: T
authors.lastname: Cole
authors.forename: Yvonne
authors.initials: Y
authors.lastname: D'Souza
authors.forename: Assad
authors.initials: A
authors.lastname: Jalil
mesh_terms: D000328:Adult; D000792:Angiography / Q000295:instrumentation / Q000379:methods*; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000000981:diagnostic imaging; D008297:Male; D015861:Retinal Neovascularization / Q000000981:diagnostic imaging*; D012171:Retinal Vessels / Q000000981:diagnostic imaging; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*; D055815:Young Adult