title: Partial matching of blood group antigens to reduce alloimmunization in Western India.
abstract: Red blood cell alloimmunization occurs due to the genetic disparity of red cell antigens between donor and recipient. In the present study, we report a spectrum of red cell alloantibodies characterized in patients with different clinical conditions in a reference center in India. Majority of the antibodies identified were against the blood group antigens c, D, E, M, N, S, s and Jka. Hence, apart from ABO and RhD, we recommend partial antigen matching between donor and patients for other Rh (C, c, E, e) and MNS blood group antigens to potentially reduce the risk of alloimmunization by 75%. Matching of Kell antigen is not recommended in Western India.
authors.affiliation: National Institute of Immunohaematology, 13th Floor New Multistoreyed Building, K. E. M. Hospital, Parel, Mumbai, Maharashtra 400091, India.
authors.forename: Harita
authors.initials: H
authors.lastname: Gogri
authors.affiliation: National Institute of Immunohaematology, 13th Floor New Multistoreyed Building, K. E. M. Hospital, Parel, Mumbai, Maharashtra 400091, India. Electronic address: swatiskulkarni@gmail.com.
authors.forename: Swati
authors.initials: S
authors.lastname: Kulkarni
authors.affiliation: National Institute of Immunohaematology, 13th Floor New Multistoreyed Building, K. E. M. Hospital, Parel, Mumbai, Maharashtra 400091, India.
authors.forename: K
authors.initials: K
authors.lastname: Vasantha
authors.affiliation: National Institute of Immunohaematology, 13th Floor New Multistoreyed Building, K. E. M. Hospital, Parel, Mumbai, Maharashtra 400091, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Jadhav
authors.affiliation: National Institute of Immunohaematology, 13th Floor New Multistoreyed Building, K. E. M. Hospital, Parel, Mumbai, Maharashtra 400091, India.
authors.forename: Kanjaksha
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: National Institute of Immunohaematology, 13th Floor New Multistoreyed Building, K. E. M. Hospital, Parel, Mumbai, Maharashtra 400091, India.
authors.forename: Ajit
authors.initials: A
authors.lastname: Gorakshakar
mesh_terms: D001789:Blood Group Antigens / Q000097:blood*; D001787:Blood Group Incompatibility / Q000097:blood* / Q000453:epidemiology*; D001788:Blood Grouping and Crossmatching; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male
chemical_list: D001789:Blood Group Antigens
keywords: Alloimmunization; India; Multiple antibodies; Partial antigen matching