title: Gracilone, a new sesquiterpene lactone from Tanacetum gracile (Tansies).
abstract: The methanolic extract of the Tanacetum gracile afforded the isolation of new sesquiterpene lactone, named gracilone (1) along with four known compounds as 14α-taraxeran-3-one (2), 14α-taraxeran-3-ol (3), apigenin (4) and β-sitosterol (5). The structure of compound 1 was elucidated on the basis of 1D, 2D NMR and MS spectroscopic analysis. Antimicrobial, antioxidant and anticancer activities of all compounds were evaluated, from which gracilone (1) showed a moderate antibacterial activity, while apigenin (4) showed comparatively more antibacterial activity against both gram-positive and gram-negative tested strains.
authors.affiliation: a Natural Products Chemistry Division , CSIR-Indian Institute of Integrative Medicine , Srinagar , India.|b Department of Biochemistry , University of Kashmir , Srinagar , India.
authors.forename: Gulzar
authors.initials: G
authors.lastname: Bhat
authors.affiliation: b Department of Biochemistry , University of Kashmir , Srinagar , India.
authors.forename: Akbar
authors.initials: A
authors.lastname: Masood
authors.affiliation: f Phytochemistry Laboratories, Centre of Research for Development , University of Kashmir , Srinagar , India.
authors.forename: Bashir A
authors.initials: BA
authors.lastname: Ganai
authors.affiliation: c Department of Clinical Biochemistry , University of Kashmir , Srinagar , India.
authors.forename: Baseerat
authors.initials: B
authors.lastname: Hamza
authors.affiliation: c Department of Clinical Biochemistry , University of Kashmir , Srinagar , India.
authors.forename: Showkat
authors.initials: S
authors.lastname: Ganie
authors.affiliation: d Department of Zoology , MLB College, University of Bhopal , Bhopal , India.
authors.forename: Tasfi
authors.initials: T
authors.lastname: Shafi
authors.affiliation: e Department of Pharmaceutical Sciences , Oregon State University , Corvallis , OR , USA.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idris
authors.affiliation: a Natural Products Chemistry Division , CSIR-Indian Institute of Integrative Medicine , Srinagar , India.
authors.forename: Abdul S
authors.initials: AS
authors.lastname: Shawl
authors.affiliation: f Phytochemistry Laboratories, Centre of Research for Development , University of Kashmir , Srinagar , India.
authors.forename: Mudasir A
authors.initials: MA
authors.lastname: Tantry
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012855:Sitosterols / Q000302:isolation & purification / Q000494:pharmacology; D031203:Tanacetum / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D007783:Lactones; D012717:Sesquiterpenes; D012855:Sitosterols; C000619085:gracilone; C025473:gamma-sitosterol
keywords: Tanacetum gracile; antibacterial; anticancer activity; antioxidant; gracilone