title: The role of stem cells in limb regeneration.
abstract: Limb regeneration is a complex yet fascinating process observed to some extent in many animal species, though seen in its entirety in urodele amphibians. Accomplished by formation of a morphologically uniform intermediate, the blastema, scientists have long attempted to define the cellular constituents that enable regrowth of a functional appendage. Today, we know that the blastema consists of a variety of multipotent progenitor cells originating from a variety of tissues, and which contribute to limb tissue regeneration in a lineage-restricted manner. By continuing to dissect the role of stem cells in limb regeneration, we can hope to one day modulate the human response to limb amputation and facilitate regrowth of a working replacement.
authors.affiliation: a Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine , Stanford , CA , USA.
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Zielins
authors.affiliation: a Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine , Stanford , CA , USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Ransom
authors.affiliation: a Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine , Stanford , CA , USA.
authors.forename: Tripp E
authors.initials: TE
authors.lastname: Leavitt
authors.affiliation: a Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine , Stanford , CA , USA.|b Institute for Stem Cell Biology and Regenerative Medicine, Stanford University , Stanford , CA , USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Longaker
authors.affiliation: a Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine , Stanford , CA , USA.
authors.forename: Derrick C
authors.initials: DC
authors.lastname: Wan
mesh_terms: D000818:Animals; D005121:Extremities / Q000254:growth & development*; D039902:Multipotent Stem Cells; D012038:Regeneration
keywords: axolotl; digit tip; limb regeneration; stem cells; urodele