title: Comparison of Performance Characteristics of Oval Cup Forceps Versus Serrated Jaw Forceps in Gastric Biopsy.
abstract: Obtaining quality endoscopic biopsy specimens is vital in making successful histological diagnoses. The influence of forceps cup shape and size on quality of biopsy specimens is unclear.
  
  
  
  To identify whether oval cup or two different serrated jaw biopsy forceps could obtain specimens of superior size. Secondary endpoints were tissue adequacy, depth of tissue acquisition, and crush artifact.
  
  
  
  A single-center, prospective, pathologist-masked, randomized controlled trial was performed. In total 136 patients with a clinical indication for esophagogastroduodenoscopy with biopsy were randomized to receive serial biopsies with a large-capacity serrated forceps with jaw diameter 2.2 mm (SER1) and either a large-capacity oval forceps with jaw diameter 2.4 mm (OVL) or large-capacity serrated biopsy forceps with jaw diameter 2.4 mm (SER2) in two parallel groups.
  
  
  
  SER2 provided significantly larger specimens than did the other forceps (SER2 3.26 ± 1.09 vs. SER1 2.92 ± 0.88 vs. OVL 2.92 ± 0.76; p = 0.026), with an average size difference of 0.34 mm greater with SER2 compared to SER1 and OVL. OVL provided significantly deeper biopsies compared to SER1 and SER2 (p = 0.02), with 31 % of OVL biopsies reaching the submucosa. SER2 had significantly less crush artifact than SER1 and OVL (p < 0.0001).
  
  
  
  Serrated forceps provided larger samples compared to oval jaw forceps of the same size, with SER2 providing the largest specimen size. Oval cup forceps had deeper penetration of epithelium, while the larger jaw diameter serrated jaw forceps had less crush artifact. All three forceps provided specimens adequate for diagnostic purposes.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, 1120 NW 14th Street, Clinical Research Building, Suite 1116, Miami, FL, 33136, USA. dsussman@med.miami.edu.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Sussman
authors.affiliation: Division of Gastroenterology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, 1120 NW 14th Street, Clinical Research Building, Suite 1116, Miami, FL, 33136, USA.
authors.forename: Amar R
authors.initials: AR
authors.lastname: Deshpande
authors.affiliation: Aventura Hospital and Medical Center, Aventura, FL, 33180, USA.
authors.forename: Uday
authors.initials: U
authors.lastname: Shankar
authors.affiliation: Division of Gastroenterology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, 1120 NW 14th Street, Clinical Research Building, Suite 1116, Miami, FL, 33136, USA.
authors.forename: Jodie A
authors.initials: JA
authors.lastname: Barkin
authors.affiliation: Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Medina
authors.affiliation: Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Poppiti
authors.affiliation: Health Professions Division, Department of Clinical Pharmacology, Nova Southeastern University, Davie, FL, 33328, USA.
authors.forename: Luigi X
authors.initials: LX
authors.lastname: Cubeddu
authors.affiliation: Division of Gastroenterology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, 1120 NW 14th Street, Clinical Research Building, Suite 1116, Miami, FL, 33136, USA.
authors.forename: Jamie S
authors.initials: JS
authors.lastname: Barkin
mesh_terms: D001706:Biopsy / Q000295:instrumentation* / Q000379:methods; D016145:Endoscopy, Digestive System; D004867:Equipment Design; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D016037:Single-Blind Method; D013270:Stomach / Q000473:pathology*; D013272:Stomach Diseases / Q000473:pathology*; D013525:Surgical Instruments
keywords: Biopsy; Forceps; Oval; Serrated; Size