title: Leptin, IL-6 and TNF-α levels in umbilical cord blood of healthy term newborns in relation to mode of delivery.
abstract: In the development of the foetal immune system, cytokines play an important role in its function. Therefore, we sought to determine whether the mode of delivery affects the expression of leptin, IL-6 and TNF-α in umbilical cord blood in healthy term newborns. We collected 125 samples of umbilical cord blood to analyse leptin, IL-6 y TNF-α levels with multiplex immunoassay (MIA). The samples were classified according to mode of delivery: vaginal delivery (VD) and caesarean section (CS). Leptin and IL-6 had higher concentrations in umbilical cord blood in VD than in CS: 42.55 ng/ml (11.92-104.28) versus 35.20 ng/ml (3.26-9326.76), p  =  0.039; 9.32 pg/ml (1.13-2020.31) versus 3.81 pg/ml (0.52-834.69) p < 0.001, respectively. Also, a weak correlation between TNF-α and IL-6 was found (r = 0.238, p = 0.007). The most important finding in our study was the differential concentrations of leptin and IL-6 according to mode of delivery.
authors.affiliation: a Department of Pediatrics and.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Treviño-Garza
authors.affiliation: a Department of Pediatrics and.
authors.forename: Laura
authors.initials: L
authors.lastname: Villarreal-Martínez
authors.affiliation: a Department of Pediatrics and.
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Estrada-Zúñiga
authors.affiliation: b Department of Gynaecology and Obstetrics , Dr. José E. González University Hospital, Universidad Autónoma De Nuevo León , Monterrey , Nuevo León , México.
authors.forename: Mariana
authors.initials: M
authors.lastname: Leal-Treviño
authors.affiliation: a Department of Pediatrics and.
authors.forename: Isaías
authors.initials: I
authors.lastname: Rodríguez-Balderrama
authors.affiliation: a Department of Pediatrics and.
authors.forename: Adriana
authors.initials: A
authors.lastname: Nieto-Sanjuanero
authors.affiliation: a Department of Pediatrics and.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Cárdenas-Del Castillo
authors.affiliation: a Department of Pediatrics and.
authors.forename: Fernando F
authors.initials: FF
authors.lastname: Montes-Tapia
authors.affiliation: a Department of Pediatrics and.
authors.forename: Manuel
authors.initials: M
authors.lastname: de la O-Cavazos
mesh_terms: D015331:Cohort Studies; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D011247:Pregnancy; D047929:Term Birth / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha
keywords: IL-6; Leptin; TNF-α; cord blood; mode of delivery; term newborn