title: Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
abstract: A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally). This effect manifested in suppression of depression-like behavior in the Porsolt forced swimming test (shortening of immobility time and increase in immobility latency, number of jumping episodes, and time of active swimming) and sucrose consumption/preference test (increase in the consumption of 20% sucrose solution in g/100 g body weight and percentage of sucrose preference in relation to the total fluid preference). Adeprophen had a greater antidepressant effect than sertraline and fluoxetine, but was less potent than amitriptyline, imipramine, venlafaxine, and to a lesser extent to paroxetine.
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ozerov
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. vvbagmetova@gmail.com.
authors.forename: V V
authors.initials: VV
authors.lastname: Bagmetova
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Chernysheva
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D005473:Fluoxetine / Q000494:pharmacology; D005518:Food Preferences / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017374:Paroxetine / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000009:adverse effects*; D020280:Sertraline / Q000494:pharmacology; D000069470:Venlafaxine Hydrochloride / Q000494:pharmacology
chemical_list: C000600956:9-(2-(4-isopropylphenoxy)ethyl)adenine; D000928:Antidepressive Agents; D005473:Fluoxetine; D000639:Amitriptyline; D017374:Paroxetine; D000069470:Venlafaxine Hydrochloride; D012110:Reserpine; D000225:Adenine; D007099:Imipramine; D020280:Sertraline
keywords: (aryloxyalkyl)adenine derivatives; adeprophen (VMA-99-82); antidepressants; reserpine-induced depression