title: Decreased gray matter volume is associated with the subtypes of psychotic symptoms in patients with antipsychotic-naïve mild or moderate Alzheimer's disease: A voxel-based morphometry study.
abstract: The purpose of this study was to investigate the association between brain regional gray matter volume and two subtypes of psychotic symptoms, namely paranoid and misidentification subtypes, in antipsychotic-naïve mild or moderate Alzheimer's disease (AD) patients. Forty AD patients with psychotic symptoms and 25 AD patients without psychotic symptoms were assessed for cognitive and functional impairment. Presence and subtype of psychotic symptoms were assessed by using the delusion and hallucination subscale of the Korean Neuropsychiatric Inventory (K-NPI). Structural MRI images were acquired on a 3 T scanner, and were analyzed using voxel-based morphometry (VBM) for automated analysis. The misidentification subtype is associated with more severe gray matter atrophy, and paranoid subtype is associated with less severe gray matter atrophy compared to non-psychosis group. These results suggest that the misidentification, the paranoid subtype and the non-psychosis group have a distinct neural correlation.
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea. Electronic address: yichung@pusan.ac.kr.
authors.forename: Young-In
authors.initials: YI
authors.lastname: Chung
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Je-Min
authors.initials: JM
authors.lastname: Park
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Byung-Dae
authors.initials: BD
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Eunsoo
authors.initials: E
authors.lastname: Moon
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Hee-Jeong
authors.initials: HJ
authors.lastname: Jeong
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Radiology, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Hak-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering and FIRST, Inje University, Gimhae, Korea.
authors.forename: Chi-Woong
authors.initials: CW
authors.lastname: Mun
authors.affiliation: Department of Biomedical Engineering and FIRST, Inje University, Gimhae, Korea.
authors.forename: Tae-Hyung
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Medical School, Inje University, Haeundae Paik Hospital, Busan, Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Neurology, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology; D001284:Atrophy / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D003702:Delusions / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006212:Hallucinations / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology
keywords: Alzheimer's disease; The gray matter volumes; The subtypes of psychotic symptoms