title: Novel illudalane sesquiterpenes from Encephalartos villosus Lehm. antimicrobial activity.
abstract: Phytochemical investigation of Encephalartos villosus Lehm. leaves afford two new illudalane sesquiterpenes namely Encephaldiene 1 and Encephaldiene 2 together with four known flavone glycosides, Luteolin-7-rutinoside, Luteolin-7-glucoside, Luteolin-7-rhamnoside and Apigenin-7-glucoside. The structures of the isolated compounds were elucidated by means of spectroscopic methods including 1D and 2D NMR experiments along with HRESIMS spectrometry. Antimicrobial activity of CHCl3and MeOH extracts was investigated. Both extracts showed antibacterial activity against Gram-positive bacteria Streptococcus pneumonia and Bacillus subtilis, and antifungal activity against Aspergillus fumigatus. While CHCl3extract showed additional activity against Gram-negative bacteria Escherichia coli.
authors.affiliation: a Faculty of Pharmacy, Department of Pharmacognosy , Umm Al-Qura University , Makkah , Saudi Arabia.|b Faculty of Pharmacy (Girls), Department of Pharmacognosy , Al-Azhar University , Cairo , Egypt.
authors.forename: Abeer
authors.initials: A
authors.lastname: Temraz
keywords: antimicrobial activity; encephaldiene; illudalane sesquiterpenes