title: Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis.
abstract: A fast and reproducible microwave-driven protocol has been developed for the synthesis of neridronate-functionalized nanoparticles. Starting from the synthesis of hydrophobic nanoparticles, our method is based on an adaptation from thermal decomposition method to microwave driven synthesis. The new methodology produces a decrease in the reaction times in comparison with traditional procedures. Moreover, the use of the microwave technology increases the reproducibility of the reactions, something important from the point of view of clinical applications. The novelty of this iron oxide nanoparticle is the attachment of Neridronate. The use of this molecule leads a bisphosphonate moiety towards the outside of the nanoparticle that provides Ca2+ binding properties in vitro and selective accumulation in vivo in the atheroma plaque. The protocol allows the synthesis and plaque detection in about 3 hr since the initial synthesis from organic precursors. Their accumulation in the atherosclerotic area in less than 1 hr provides a contrast agent particularly suitable for clinical applications.
authors.affiliation: Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III and CIBER de Enfermedades Respiratorias; Universidad Complutense de Madrid.
authors.forename: Juan
authors.initials: J
authors.lastname: Pellico
authors.affiliation: Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III and CIBER de Enfermedades Respiratorias; Universidad Complutense de Madrid.
authors.forename: Jesús
authors.initials: J
authors.lastname: Ruiz-Cabello
authors.affiliation: Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III and CIBER de Enfermedades Respiratorias; fernando.herranz@cnic.es.
authors.forename: Fernando
authors.initials: F
authors.lastname: Herranz
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D005290:Ferric Compounds / Q000138:chemical synthesis*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008872:Microwaves; D053758:Nanoparticles; D019301:Oleic Acid / Q000737:chemistry; D058226:Plaque, Atherosclerotic / Q000175:diagnosis*; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D019301:Oleic Acid