title: Comparison of Hepatic Resection and Radiofrequency Ablation for the Treatment of Colorectal Liver Metastasis.
abstract: The liver is the major site of metastasis of primary colorectal cancer. Hepatic resection (HR) is considered the standard treatment for colorectal liver metastasis. In high-risk cases, radiofrequency ablation (RFA) can be attempted as an alternative treatment. This study compared the clinical profiles and overall and disease-free survival rates of patients with colorectal liver metastasis undergoing HR and RFA. From 1995 to 2009, we retrospectively analyzed clinical experiences of 43 and 17 patients who had undergone HR and RFA for primary colorectal cancer, respectively. To compare outcomes, we investigated the 3-year overall and disease-free survival rates. The 3-year overall survival rates of patients treated with HR and RFA were 53.5 and 47.1 %, respectively (p = 0.285); the disease-free survival rates were 35.0 and 26.9 %, respectively (p = 0.211). In the HR and RFA groups, 30 (60.2 %) and 13 (76.5 %) patients developed recurrence, respectively (p = 0.604). In the HR group, 1 patient died from postoperative liver failure, and 9 (20.9 %) developed postoperative complications, including wound infection, biliary leakage, intra-abdominal abscess, and pneumonia. In the RFA group, 1 patient (5.9 %) required prolonged inpatient care because of a procedure-related liver abscess. Although HR should be considered the first option for colorectal liver metastasis, RFA can be regarded as a primary treatment modality depending on the patient's characteristics, especially when a patient refuses surgery or has comorbidities.
authors.affiliation: Department of Surgery, Haeundae Paik Hospital, University of Inje College of Medicine, 1435, Jwa-dong, Haeundae-gu, Busan, 612-030 South Korea.
authors.forename: Woon-Won
authors.initials: WW
authors.lastname: Kim
authors.affiliation: Department of Surgery, Haeundae Paik Hospital, University of Inje College of Medicine, 1435, Jwa-dong, Haeundae-gu, Busan, 612-030 South Korea.
authors.forename: Ki Hoon
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Haeundae Paik Hospital, University of Inje College of Medicine, 1435, Jwa-dong, Haeundae-gu, Busan, 612-030 South Korea.
authors.forename: Sam Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Haeundae Paik Hospital, University of Inje College of Medicine, 1435, Jwa-dong, Haeundae-gu, Busan, 612-030 South Korea.
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Surgery, Haeundae Paik Hospital, University of Inje College of Medicine, 1435, Jwa-dong, Haeundae-gu, Busan, 612-030 South Korea.
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Busan Paik Hospital, University of Inje College of Medicine, Busan, South Korea.
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Busan Paik Hospital, University of Inje College of Medicine, Busan, South Korea.
authors.forename: Chang Su
authors.initials: CS
authors.lastname: Choi
authors.affiliation: Busan Paik Hospital, University of Inje College of Medicine, Busan, South Korea.
authors.forename: Young Kil
authors.initials: YK
authors.lastname: Choi
keywords: Colorectal cancer; Hepatic resection; Liver metastasis; Radiofrequency ablation