title: [Endogenous bacterial and fungal endophthalmitis at Nice University Medical Center: A 15-year case review].
abstract: OBJECTIVE
  To evaluate epidemiology, diagnostic and therapeutic management strategies and visual outcomes of cases of bacterial and fungal endogenous endophthalmitis managed in the Nice University Medical Center between January 2000 and June 2015.
  
  
  METHODS
  Three hundred twenty-three charts of patients with endophthalmitis treated at the Nice University Medical Center over this period were retrospectively reviewed to select the ones with endogenous endophthalmitis. Demographic characteristics, medical history, clinical presentation, diagnostic and therapeutic management, microbiology, and final outcomes were analyzed.
  
  
  RESULTS
  Twenty-two eyes of 20 patients were selected, constituting 6.20% of all cases of endophthalmitis. The mean age was 69years, and 75% of patients were male. The most common risk factors were diabetes, malignancies and cardiac diseases. Bacterial isolates were found in 16 cases (80%), fungal isolates in 3 (15%) and co-infection in 1 case. Gram-positive organisms accounted for 70.6% of cases (mostly Staphylococcus aureus [25%], Streptococcus agalactiae [25%] and Streptococcus pneumoniae [16.7%]). Candida albicans was the most common fungal organism. There was one bacterial and fungal co-infection. Two patients died, 4 eyes were enucleated or eviscerated (20%), and 4 patients (20%) attained a final visual acuity of 1/10 or better.
  
  
  CONCLUSIONS
  Endogenous endophthalmitis is a rare and serious condition with a poor prognosis. Gram-positive microorganisms, mostly S. aureus, were the main causative pathogens found.
authors.affiliation: Service d'ophtalmologie, hôpital Pasteur 2, centre hospitalo-universitaire de Nice, 30, avenue de la Voie-Romaine, 06000 Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Landré
authors.affiliation: Service d'ophtalmologie, hôpital Pasteur 2, centre hospitalo-universitaire de Nice, 30, avenue de la Voie-Romaine, 06000 Nice, France. Electronic address: baillif.s@chu-nice.fr.
authors.forename: S
authors.initials: S
authors.lastname: Baillif
mesh_terms: D000046:Academic Medical Centers; D000368:Aged; D000369:Aged, 80 and over; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D009877:Endophthalmitis / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology* / Q000628:therapy; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013290:Streptococcal Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D013292:Streptococcus agalactiae / Q000302:isolation & purification
keywords: Bacterial endophthalmitis; Endogenous endophthalmitis; Endophtalmie bactérienne; Endophtalmie endogène; Endophtalmie fongique; Eye infection; Fungal endophthalmitis; Infection oculaire