title: New Insights into the Regulation of Heterochromatin.
abstract: All living organisms are constantly exposed to stresses from internal biological processes and surrounding environments, which induce many adaptive changes in cellular physiology and gene expression programs. Unexpectedly, constitutive heterochromatin, which is generally associated with the stable maintenance of gene silencing, is also dynamically regulated in response to stimuli. In this review we discuss the mechanism of constitutive heterochromatin assembly, its dynamic nature, and its responses to environmental changes.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, USA.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, USA.
authors.forename: Sharon T
authors.initials: ST
authors.lastname: Jia
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, USA. Electronic address: jia@biology.columbia.edu.
authors.forename: Songtao
authors.initials: S
authors.lastname: Jia
mesh_terms: D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D005786:Gene Expression Regulation; D020868:Gene Silencing; D059647:Gene-Environment Interaction; D006570:Heterochromatin / Q000235:genetics*; D006657:Histones / Q000235:genetics; D006801:Humans; D014158:Transcription, Genetic
chemical_list: D006570:Heterochromatin; D006657:Histones
keywords: constitutive heterochromatin; dynamics; epigenetic adaptation; stress