title: Serum matrix metalloproteinase-2: A potential biomarker for diagnosis of epilepsy.
abstract: OBJECTIVE
  In this study, we evaluate the utility of serum metalloproteinase-2 (MMP-2) as a biomarker for the diagnosis of epilepsy.
  
  
  METHODS
  We assessed serum MMP-2 levels in 233 epileptic and 97 healthy control subjects. Control subjects had no complaints or signs of neurological disorders for at least 12 months prior to serum collection. Serum MMP-2 levels were determined using the Luminex technology.
  
  
  RESULTS
  Compared with controls, subjects with epilepsy had significantly lower serum MMP-2 concentrations (P<0.05). There was no significant difference between males and females in either group (P>0.05). Serum MMP-2 concentrations were highly correlated with age in both groups, and this correlation was strongest for males. When an MMP-2 cut-off value of 175.40ng/ml was used, the sensitivity for distinguishing subjects with epilepsy from controls was 71.13% and the specificity was 62.66%.
  
  
  CONCLUSIONS
  Our results reveal that serum MMP-2 may be a potential biomarker for the diagnosis of epilepsy.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: 1046792011@qq.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Laboratory, Pengzhou People's Hospital, Chengdu, Sichuan, People's Republic of China. Electronic address: 568079831@qq.com.
authors.forename: Guang Qun
authors.initials: GQ
authors.lastname: Zeng
authors.affiliation: Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: sunnyt.r.zhan@163.com.
authors.forename: Rui Zhan
authors.initials: RZ
authors.lastname: Tong
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: zhoudong66@yahoo.de.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: Hongzhengoog@aliyun.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000187:drug effects; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D015415:Biomarkers; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: Biomarker; Epilepsy; Metalloproteinase; Serum