title: Extracellular vesicles as new players in angiogenesis.
abstract: Growing evidence suggests that small vesicles actively released from cells may encapsulate transcriptional regulators and RNA molecules. Their ability to interact with neighbouring cells and/or with distant cells through biological fluids, makes them a medium through which intercellular exchange of information can happen. Recently, membrane vesicles, which include exosomes and microvesicles, gained a place amongst the vast group of angiogenic mediators. In the present review we discuss the potential relevance of these vesicles in physiological and pathological situations of angiogenesis as well as their mechanism of action.
authors.affiliation: Molecular Biotechnology Center, Department of Medical Sciences, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Sharad
authors.initials: S
authors.lastname: Kholia
authors.affiliation: Molecular Biotechnology Center, Department of Medical Sciences, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ranghino
authors.affiliation: Department of Surgical Sciences, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Garnieri
authors.affiliation: Molecular Biotechnology Center, Department of Medical Sciences, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Lopatina
authors.affiliation: Molecular Biotechnology Center, Department of Medical Sciences, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Deregibus
authors.affiliation: Department of Surgical Sciences, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Rispoli
authors.affiliation: Molecular Biotechnology Center, Department of Medical Sciences, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Maria Felice
authors.initials: MF
authors.lastname: Brizzi
authors.affiliation: Molecular Biotechnology Center, Department of Medical Sciences, Corso Dogliotti 14, 10126 Torino, Italy. Electronic address: giovanni.camussi@unito.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Camussi
mesh_terms: D000818:Animals; D055354:Exosomes / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000378:metabolism*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D012313:RNA / Q000378:metabolism
chemical_list: D012313:RNA
keywords: Angiogenesis; Exosomes; Microvesicles; miRNAs