title: Mod(mdg4)-58.8, isoform of mod(mdg4) loci, directly interacts with MTACP1A and MTACP1B proteins of Drosophila melanogaster.
abstract: As a result of experiments in yeast two-hybrid system, coimmunoprecipitation of proteins from D. melanogaster embryo cell lysate, and immunostaining, it was shown for the first time that Mod(mdg4)-58.8 protein (isoform P), a product of mod(mdg4) locus, directly interacts with mtACP1A and mtACP1B proteins. These proteins are involved in de novo biosynthesis of fatty acids in mitochondria and are required for normal gametogenesis in males and females and, possibly, for the trachea development. This result expands the understanding of the role of mod(mdg4) locus products in the regulation of life activity of the eukaryotic cell.
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia. lsm73@mail.ru.
authors.forename: A K
authors.initials: AK
authors.lastname: Golovnin
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Kostyuchenko
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia.
authors.forename: P G
authors.initials: PG
authors.lastname: Georgiev
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia.
authors.forename: L S
authors.initials: LS
authors.lastname: Melnikova
mesh_terms: D000213:Acyl Carrier Protein / Q000378:metabolism*; D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D008297:Male; D024101:Mitochondrial Proteins / Q000378:metabolism*; D011485:Protein Binding; D020033:Protein Isoforms / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D000213:Acyl Carrier Protein; D029721:Drosophila Proteins; D024101:Mitochondrial Proteins; D020033:Protein Isoforms; D014157:Transcription Factors; C101384:mod(mdg4) protein, Drosophila