title: Risk factors for mortality in end-stage kidney disease patients under online-hemodiafiltration: three-year follow-up study.
abstract: The aim of this work was to evaluate the predictors of mortality in a group of end-stage kidney disease (ESRD) patients under dialysis, by performing a three-year follow-up study. From the 236 patients included in this study, 54 patients died during the three-year follow-up period. Our data showed that the risk of death was higher in patients presenting lower levels of mean cell hemoglobin concentration, transferrin, and albumin. Our study showed that poor nutritional status and an inflammatory-induced iron depleted erythropoiesis are important factors for mortality in these patients.
authors.affiliation: a Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto , Portugal ;
authors.forename: Pedro de
authors.initials: Pd
authors.lastname: Sousa-Martins
authors.affiliation: b Instituto de Ciências da Saúde, Universidade Católica Portuguesa , Porto , Portugal ;
authors.forename: Alexandra
authors.initials: A
authors.lastname: Moura
authors.affiliation: c Clínica de Hemodiálise NefroServe , Barcelos , Portugal ;
authors.forename: José
authors.initials: J
authors.lastname: Madureira
authors.affiliation: c Clínica de Hemodiálise NefroServe , Barcelos , Portugal ;
authors.forename: Pablo
authors.initials: P
authors.lastname: Alija
authors.affiliation: d Centro Hospitalar do Porto , Porto , Portugal ;
authors.forename: José Gerardo
authors.initials: JG
authors.lastname: Oliveira
authors.affiliation: e Clínica de Hemodiálise de Felgueira , Felgueiras , Portugal ;
authors.forename: Martin
authors.initials: M
authors.lastname: Lopez
authors.affiliation: f Clínica de Hemodiálise de Gondomar , Gondomar , Portugal ;
authors.forename: Madalena
authors.initials: M
authors.lastname: Filgueiras
authors.affiliation: g Clínica de Hemodiálise NephroCare , Maia , Portugal ;
authors.forename: Leonilde
authors.initials: L
authors.lastname: Amado
authors.affiliation: g Clínica de Hemodiálise NephroCare , Maia , Portugal ;
authors.forename: Maria
authors.initials: M
authors.lastname: Sameiro-Faria
authors.affiliation: g Clínica de Hemodiálise NephroCare , Maia , Portugal ;
authors.forename: Vasco
authors.initials: V
authors.lastname: Miranda
authors.affiliation: h Núcleo de Estudantes de Estatística, Universidade do Minho , Braga , Portugal ;
authors.forename: Edgar
authors.initials: E
authors.lastname: Mesquita
authors.affiliation: a Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto , Portugal ;
authors.forename: Laetitia
authors.initials: L
authors.lastname: Teixeira
authors.affiliation: a Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto , Portugal ;
authors.forename: Verónica
authors.initials: V
authors.lastname: Poveda
authors.affiliation: i Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto , Portugal ;|j Serviço de Nefrologia & Departamento de Ensino , Formação e Investigação, Centro Hospitalar do Porto , Porto , Portugal ;
authors.forename: Luísa
authors.initials: L
authors.lastname: Lobato
authors.affiliation: k Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia , Universidade do Porto , Porto , Portugal ;|l UCIBIO, REQUIMTE , Universidade do Porto , Porto , Portugal.
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
authors.affiliation: k Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia , Universidade do Porto , Porto , Portugal ;|l UCIBIO, REQUIMTE , Universidade do Porto , Porto , Portugal.
authors.forename: Elísio
authors.initials: E
authors.lastname: Costa
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D017583:Hemodiafiltration; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000097:blood / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D012709:Serum Albumin; D014168:Transferrin
keywords: End-stage kidney disease; health-related quality of life; inflammation; iron metabolism; mortality; nutritional status; online-hemodiafiltration