title: The effectiveness and safety of amisulpride in Chinese patients with schizophrenia: An 8-week, prospective, open-label, multicenter, single-arm study.
abstract: BACKGROUND
  This study evaluated the effectiveness and safety of amisulpride in Chinese schizophrenia patients.
  
  
  METHODS
  A multicenter, single-arm Phase IV study (NCT01795183). Chinese patients with schizophrenia received amisulpride for 8 weeks. The primary endpoint was ≥50% decrease in Positive and Negative Syndrome Scale total score from Baseline to Week 8.
  
  
  RESULTS
  A total of 316 patients were enrolled; 295 were included in the effectiveness analysis; 66.8% (197/295) achieved ≥50% decrease in Positive and Negative Syndrome Scale total score from Baseline to Week 8. Nine patients discontinued treatment because of adverse events.
  
  
  CONCLUSIONS
  Amisulpride had clinical effectiveness and was relatively well tolerated in Chinese patients with schizophrenia.
authors.affiliation: National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, and the Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen, China.
authors.forename: Changan
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Psychiatry, The Seventh People Hospital of Hangzhou, Hangzhou, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Psychiatry, Beijing An Ding Hospital, Capital Medical University, Beijing, China.
authors.forename: Chuanyue
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, The First Special Hospital of Harbin, Harbin, China.
authors.forename: Congpei
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Beijing An Ding Hospital, Capital Medical University, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Psychiatry, Beijing Huilongguan Hospital, Beijing, China.
authors.forename: Fude
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Psychiatry, Tianjin Anding hospital, Tianjin, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Psychiatry, Mental Health Centre of Shandong Province, Jinan, China.
authors.forename: Jisheng
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Psychiatry, Mental Health Centre of Shandong Province, Jinan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Su
authors.affiliation: Department of Psychiatry, Beijing Huilongguan Hospital, Beijing, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Xin
authors.affiliation: Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Minglong
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Psychiatry, Guangzhou Brain Hospital, Guangzhou, China.
authors.forename: Muni
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Psychiatry, Nanjing Brain Hospital, Nanjing, China.
authors.forename: Shiping
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of Psychiatry, Nanjing Brain Hospital, Nanjing, China.
authors.forename: Shuiping
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen, China.
authors.forename: Tiebang
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, Mental Health Center of Wu Han City, Wuhan, China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, The First Special Hospital of Harbin, Harbin, China.
authors.forename: Xijin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Guangzhou Brain Hospital, Guangzhou, China.
authors.forename: Xuanzi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Xueyi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Mental Health Center of Wu Han City, Wuhan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Tianjin Anding hospital, Tianjin, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, The Seventh People Hospital of Hangzhou, Hangzhou, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Chen
authors.affiliation: National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, and the Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012559:Schizophrenia / Q000188:drug therapy*; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride
keywords: Chinese; Schizophrenia; amisulpride; antipsychotic agents/adverse effects; antipsychotic agents/therapeutic use