title: Molecular Insight into Gut Microbiota and Rheumatoid Arthritis.
abstract: Rheumatoid arthritis (RA) is a systemic, inflammatory, and autoimmune disorder. Gut microbiota play an important role in the etiology of RA. With the considerable progress made in next-generation sequencing techniques, the identified gut microbiota difference between RA patients and healthy individuals provides an updated overview of the association between gut microbiota and RA. We reviewed the reported correlation and underlying molecular mechanisms among gut microbiota, the immune system, and RA. It has become known that gut microbiota contribute to the pathogenesis of RA via multiple molecular mechanisms. The progressive understanding of the dynamic interaction between gut microbiota and their host will help in establishing a highly individualized management for each RA patient, and achieve a better efficacy in clinical practice, or even discovering new drugs for RA.
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. wxho0606@163.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. wxho0606@163.com.
authors.forename: Xiaohao
authors.initials: X
authors.lastname: Wu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. hebinghb@gmail.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. hebinghb@gmail.com.
authors.forename: Bing
authors.initials: B
authors.lastname: He
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. liujin_hkbu@163.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. liujin_hkbu@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Guanghua Integrative Hospital, Shanghai 200000, China. 13816671472@163.com.|Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. 13816671472@163.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Feng
authors.affiliation: Guanghua Integrative Hospital, Shanghai 200000, China. mayinghui021@126.com.|Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. mayinghui021@126.com.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. lidefang@163.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. lidefang@163.com.|Research Group of Bone and Joint Diseases, HKBU Institute of Science &amp; Technology, Haimen 226100, China. lidefang@163.com.
authors.forename: Defang
authors.initials: D
authors.lastname: Li
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. borisguo@hkbu.edu.hk.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. borisguo@hkbu.edu.hk.|Research Group of Bone and Joint Diseases, HKBU Institute of Science &amp; Technology, Haimen 226100, China. borisguo@hkbu.edu.hk.
authors.forename: Baosheng
authors.initials: B
authors.lastname: Guo
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. liangchao512@163.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. liangchao512@163.com.|Research Group of Bone and Joint Diseases, HKBU Institute of Science &amp; Technology, Haimen 226100, China. liangchao512@163.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. danglei_hkbu@163.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. danglei_hkbu@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Dang
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. luyaoben@126.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. luyaoben@126.com.
authors.forename: Luyao
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. 14441098@life.hkbu.edu.hk.
authors.forename: Jing
authors.initials: J
authors.lastname: Tian
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. hlzhu@hkbu.edu.hk.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. hlzhu@hkbu.edu.hk.
authors.forename: Hailong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Guanghua Integrative Hospital, Shanghai 200000, China. 13701888178@163.com.|Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. 13701888178@163.com.
authors.forename: Lianbo
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. lv_cheng0816@163.com.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. lv_cheng0816@163.com.|Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China. lv_cheng0816@163.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. aipinglu@hkbu.edu.hk.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. aipinglu@hkbu.edu.hk.|Guanghua Integrative Hospital, Shanghai 200000, China. aipinglu@hkbu.edu.hk.|Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. aipinglu@hkbu.edu.hk.|Research Group of Bone and Joint Diseases, HKBU Institute of Science &amp; Technology, Haimen 226100, China. aipinglu@hkbu.edu.hk.|Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China. aipinglu@hkbu.edu.hk.
authors.forename: Aiping
authors.initials: A
authors.lastname: Lu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. zhangge@hkbu.edu.hk.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. zhangge@hkbu.edu.hk.|Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. zhangge@hkbu.edu.hk.|Research Group of Bone and Joint Diseases, HKBU Institute of Science &amp; Technology, Haimen 226100, China. zhangge@hkbu.edu.hk.
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D064307:Microbiota
keywords: gut microbiota; molecular mechanism; rheumatoid arthritis