title: A biased view toward celiac disease.
abstract: Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.
authors.affiliation: Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.|Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.|Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Rossjohn
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Koning
mesh_terms: D002446:Celiac Disease; D000939:Epitopes; D005983:Glutens; D006801:Humans; D009457:Neuroglia; D011948:Receptors, Antigen, T-Cell
chemical_list: D000939:Epitopes; D011948:Receptors, Antigen, T-Cell; D005983:Glutens