title: A novel prognostic inflammation score predicts outcomes in patients with ovarian cancer.
abstract: BACKGROUND
  Systemic inflammation and host immunological nutritional status play important roles in the tumorigenesis of malignant cancer. A novel prognostic inflammation score (PIS) based on preoperative serum albumin and neutrophil to lymphocyte ratio (NLR) was designed. We explored its prognostic value in ovarian cancer.
  
  
  METHODS
  143 patients with ovarian cancer were enrolled in this retrospective study. The association of the PIS with clinicopathologic parameters was analyzed. The prognostic significance was determined by univariate and multivariate cox survival analyses.
  
  
  RESULTS
  Both univariate and multivariate analyses showed that NLR and albumin were independent prognostic factors for overall survival (OS) and progression-free survival (PFS). An inverse correlation was observed between the NLR and serum albumin concentration. The novel prognostic inflammation score (PIS) was shown to be a significant predictor for OS and PFS (both P<0.001) according to multivariate analysis. Additionally, low PIS was associated with advanced tumor stage (P<0.001), metastasis (P<0.001) and preoperative high PLR (P<0.001).
  
  
  CONCLUSIONS
  The PIS is a novel but promising prognostic score in ovarian cancer. It is a significant prognostic marker adjusted for clinicopathologic characteristics to further identify patients' survival differences.
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Yuan-Qiu
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: The Department of Information and Engineering, Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Chu
authors.initials: C
authors.lastname: Jin
authors.affiliation: The Department of Ultrasonography, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Hua-Min
authors.initials: HM
authors.lastname: Zheng
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Shi
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China. Electronic address: zfy983023@hotmail.com.
authors.forename: Fei-Yun
authors.initials: FY
authors.lastname: Zheng
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China. Electronic address: 234898067@qq.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
mesh_terms: D002452:Cell Count; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D008214:Lymphocytes / Q000166:cytology; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D011379:Prognosis; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D012709:Serum Albumin
keywords: Neutrophil to lymphocyte ratio (NLR); Ovarian cancer; Prognostic; Prognostic inflammation score (PIS); Serum albumin