title: Histopathological assessment of residual retroperitoneal mass removed in patients after chemotherapy for non-seminomatous germ cell tumours of the testis.
abstract: Between 1990 and 1999, 182 men were treated for non-seminomatous germ cell testicular tumours. In 24 of them after chemotherapy a residual retroperitoneal mass was removed. In 14 of them additional immunohistochemical (IHC) examinations using antibodies against cytokeratins, vimentin, PLAP, CD30, AFP, βhCG, p53, and MIB-1 were performed. We compared the results of those additional studies with the results of routine histopathological examination. Histological assessment revealed most frequently (ca. 54% of cases) non-neoplastic lesions, i.e. fibro-cystic, necrotic or inflammatory tumours and lymphatic tissue. In about 33% of cases, surviving live neoplastic cells were found.
authors.affiliation: Janusz Jaszczyński, Urology Department of Surgical Oncology, Maria Sklodowska-Curie Memorial Cancer Center, and Institute of Oncology, Garncarska 11, 31-115 Krakow, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Jaszczyński
authors.forename: Wacław
authors.initials: W
authors.lastname: Wilk
authors.forename: Anna
authors.initials: A
authors.lastname: Kruczak
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Wohadlo
authors.forename: Piotr
authors.initials: P
authors.lastname: Faron
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Łuczyńska
authors.forename: Piotr
authors.initials: P
authors.lastname: Chłosta
authors.forename: Andrzej
authors.initials: A
authors.lastname: Stelmach
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jakubowicz
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000556:secondary*; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000556:secondary*; D012187:Retroperitoneal Space / Q000473:pathology*; D012189:Retrospective Studies; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents