title: Role of kisspeptin in polycystic ovary syndrome (PCOS).
abstract: OBJECTIVE
  Due to the complex relationship between kisspeptin and the hypothalamic-pituitary-gonadal axis, the study was planned to measure the kisspeptin levels in polycystic ovary syndrome (PCOS) and to analyze the correlations between kisspeptin and PCOS-related reproductive, metabolic changes.
  
  
  METHODS
  The study was designed as a prospective study in Dokuz Eylul University between December 2011 and September 2013. A total of 285 PCOS cases and 162 controls were recruited. After the antropometric measeruments and physcial examination, blood samples were taken for biochemical analysis.
  
  
  RESULTS
  PCOS group's mean BMI was 24.32 ± 3.40 and for the control group, BMI value was 23.44 kg/m2± 4.08 (p = 0.351). PCOS patients' FSH level was 5.10 ± 2.01 mIU/L, LH value was 7.75 ± 4.31 mIU/mL, LH/FSH ratio was 1.70 ± 1.28, DHEAS value was 221.84 ± 105.02 mg/dl, total testosterone value was 50.51 ± 27.93 ng/ml, free testosterone value was 2.52 ± 1.05 pg/ml, SHBG was 63.74 ± 45.62 nmol/L, LDL was 102.56 ± 23.45 mg/dL, HDL value was 51.36 ± 12.15 mg/dL, total cholesterol value was 214.85 ± 39.27 mg/dL, triglyceride value was 112.95 ± 46.88 mg/dL, Apo A1 value was 171.30 ± 35.35 mg/dL, Apo B value was 71.08 ± 19.07 mg/dL, Apo B/A1 ratio was 0.42 ± 0.14, free androgen index was 13.77 ± 14.15, fasting glucose value was 80.68 ± 13.80 mg/dL, fasting insulin levels was 14.13 ± 9.11 μiU/mL, HOMA-IR index was 2.76 ± 2.34, AMH value was 5.93 ± 3:33 in ng/ml, and found to be significantly higher (p < 0.001). Leptin value was 9.71 ± 5.54 pg/ml and kisspeptin value was 1.92 ± 1.29 ng/ml, respectively. Kisspeptin and leptin levels showed no statistically significant difference with control group and PCOS group. In all PCOS patients, kisspeptin showed positive correlations between LH and leptin levels.
  
  
  CONCLUSIONS
  In this study, kisspeptin had a positive correlation with LH and leptin levels in PCOS. In fact, the serum levels of kisspeptin and leptin does not differ statistically between PCOS and healthy women. There are limited data in the literature with regard to changes in kisspeptin levels and its relation with metabolic and hormonal disturbances.
authors.affiliation: a Department of Gynecology and Obstetrıcs , Konya Aksehir Public Hospital , Konya , Turkey.
authors.forename: Ozlen
authors.initials: O
authors.lastname: Emekci Ozay
authors.affiliation: a Department of Gynecology and Obstetrıcs , Konya Aksehir Public Hospital , Konya , Turkey.
authors.forename: Ali Cenk
authors.initials: AC
authors.lastname: Ozay
authors.affiliation: b Departments of Gynecology and Obstetrics.
authors.forename: Berrin
authors.initials: B
authors.lastname: Acar
authors.affiliation: b Departments of Gynecology and Obstetrics.
authors.forename: Erkan
authors.initials: E
authors.lastname: Cagliyan
authors.affiliation: c Department of Radiology , and.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Seçil
authors.affiliation: d Department of Biochemistry , Dokuz Eylul University Hospital , Izmir , Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Küme
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D059648:Kisspeptins / Q000097:blood*; D020738:Leptin / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D059648:Kisspeptins; D020738:Leptin; D007986:Luteinizing Hormone
keywords: Insulin resistance; kisspeptin; leptin; polycystic ovary syndrome