title: Association between Lp (a) and atherosclerosis in menopausal women without metabolic syndrome.
abstract: OBJECTIVE
  The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women.
  
  
  METHODS
  Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated.
  
  
  RESULTS
  Lp (a) was significantly lower in women with metabolic syndrome (MS). In a multivariate analysis Lp (a) showed the following odds ratio (OR; all p < 0.05) of having common carotid IMT (≥1.30 mm): 1.03, adjusted for age, low-density lipoprotein cholesterol (LDL) and waist circumference; 1.02, adjusted for age LDL, homeostatic assessment model (HOMA). In women without MS, after controlling for age, LDL and waist circumference, we found the following OR for increased IMT (≥1.30; OR: 1.03; for Lp [a]); 1.02 adjusted for age, LDL and HOMA (all p < 0.05). In women with MS these relationships were not statistically significant.
  
  
  CONCLUSIONS
  Lp (a) gives additional information in the risk assessment for atherosclerotic cardiovascular disease, especially in menopausal women without MS.
authors.affiliation: Department of Clinical Medicine & Surgery, University "Federico II" Medical School - Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Gentile
authors.affiliation: Department of Clinical Medicine & Surgery, University "Federico II" Medical School - Naples, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Iannuzzo
authors.affiliation: Department of Clinical Medicine & Surgery, University "Federico II" Medical School - Naples, Italy.
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.affiliation: Department of Clinical Medicine & Surgery, University "Federico II" Medical School - Naples, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Marotta
authors.affiliation: Department of Medicine, Antonio Cardarelli Hospital, Naples, Italy.
authors.forename: Arcangelo
authors.initials: A
authors.lastname: Iannuzzi
authors.affiliation: Department of Clinical Medicine & Surgery, University "Federico II" Medical School - Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.affiliation: Department of Clinical Medicine & Surgery, University "Federico II" Medical School - Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Rubba
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000032:analysis*; D008593:Menopause; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D017270:Lipoprotein(a)
keywords: Lp (a); atherosclerosis; cardiovascular risk; metabolic syndrome; ultrasound; women