title: Do advanced glycation end-products play a role in malaria susceptibility?
abstract: There are growing data supporting the differences in susceptibility to malaria described between sympatric populations with different lifestyles. Evidence has also been growing for some time that nutritional status and the host's metabolism are part of the complex mechanisms underlying these differences. The role of dietary advanced glycation end-products (AGEs) in the modulation of immune responses (innate and adaptive responses) and chronic oxidative stress has been established. But less is known about AGE implication in naturally acquired immunity and susceptibility to malaria. Since inflammatory immune responses and oxidative events have been demonstrated as the hallmark of malaria infection, it seems crucial to investigate the role of AGE in susceptibility or resistance to malaria. This review provides new insight into the relationship between nutrition, metabolic disorders, and infections, and how this may influence the mechanisms of susceptibility or resistance to malaria in endemic areas.
authors.affiliation: Malaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali - Univ Lyon, Université Claude Bernard Lyon 1, Institut de Chimie, de Biologie Moléculaire et Supramoléculaire ICBMS-UMR5246, CNRS-INSA-CPE, Malaria Research Unit, - 43 boulevard du 11 novembre 1918, 69622 Lyon, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Traoré
authors.affiliation: Malaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali.
authors.forename: Charles
authors.initials: C
authors.lastname: Arama
authors.affiliation: Univ Lyon, Université Claude Bernard Lyon 1, Institut de Chimie, de Biologie Moléculaire et Supramoléculaire ICBMS-UMR5246, CNRS-INSA-CPE, - 43 boulevard du 11 novembre 1918, 69622 Lyon, France.
authors.forename: Maurice
authors.initials: M
authors.lastname: Médebielle
authors.affiliation: Malaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali.
authors.forename: Ogobara
authors.initials: O
authors.lastname: Doumbo
authors.affiliation: Univ Lyon, Université Claude Bernard Lyon 1, Institut de Chimie, de Biologie Moléculaire et Supramoléculaire ICBMS-UMR5246, CNRS-INSA-CPE, Malaria Research Unit, - 43 boulevard du 11 novembre 1918, 69622 Lyon, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Picot
mesh_terms: D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D003296:Cooking; D004032:Diet / Q000009:adverse effects; D004198:Disease Susceptibility; D019353:Endemic Diseases; D005006:Ethnicity / Q000235:genetics; D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease; D017127:Glycation End Products, Advanced / Q000009:adverse effects*; D024243:HMGB1 Protein / Q000502:physiology; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008019:Life Style; D008285:Major Histocompatibility Complex / Q000235:genetics; D008288:Malaria / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D009752:Nutritional Status; D010961:Plasmodium / Q000235:genetics / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics / Q000502:physiology*; D012641:Selection, Genetic
chemical_list: C000593871:AGER protein, human; D017127:Glycation End Products, Advanced; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D000067759:Receptor for Advanced Glycation End Products