title: Changes in Production of Cytokines by C57Bl/6J Mouse Spleen during Aggression Provoked by Social Stress.
abstract: The effect of aggressive behavior shaped under social stress of various durations on the production of proinflammatory cytokines by splenic cells was examined on C57BL/6J mice. Aggressive mice were characterized by enhanced production of IL-2 and IFN-γ (released by T helper type 1 cells) and reduced secretion of TNF-α, whose major producers are monocytes and macrophages. Elevation of IL-2 and IFN-γ in aggressive mice resulted from enhancement of spontaneous and Con A-stimulated production, the most pronounced effect was demonstrated by the with a longer period (20 days) of victories. In contrast, spontaneous production of TNF-α was similar in control and aggressive mice, although LPS-stimulated production of this cytokine decreased after 10- and 20-day stress. The possible mechanisms of the changes in cytokine production are discussed.
authors.affiliation: Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. galina@physiol.ru.
authors.forename: G V
authors.initials: GV
authors.lastname: Idova
authors.affiliation: Department of Neuroimmunology, State Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Markova
authors.affiliation: Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: M M
authors.initials: MM
authors.lastname: Gevorgyan
authors.affiliation: Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: E L
authors.initials: EL
authors.lastname: Alperina
authors.affiliation: Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Zhukova
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003208:Concanavalin A; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008070:Lipopolysaccharides; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000378:metabolism*; D013315:Stress, Psychological; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D007376:Interleukin-2; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; D007371:Interferon-gamma
keywords: aggressive behavior; cytokines; interferone-γ; interleukin-2; tumor necrosis factor-α