title: Bisphenol A alters transcript levels of biomarker genes for Major Depressive Disorder in vascular endothelial cells and colon cancer cells.
abstract: Bisphenol A (BPA) is capable of mimicking endogenous hormones with potential consequences for human health and BPA exposure has been associated with several human diseases including neuropsychiatric disorders. Here, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) results show that BPA at low concentrations (10 ng/mL and 1 μg/mL) induces differential transcript levels of four biomarker genes for Major Depressive Disorder (MDD) in HT29 human colon adenocarcinona cell line and Human Umbilical Vein Endothelial Cells (HUVEC). These results substantiate increasing concerns of BPA exposure in levels currently detected in humans.
authors.affiliation: Landscape, Environment, Agriculture and Food (LEAF) Centre, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal; Lisbon School of Health Technology, Instituto Politécnico de Lisboa, Av. D. João II, Lote 4.69.01, 1990-096 Lisboa, Portugal.
authors.forename: Edna
authors.initials: E
authors.lastname: Ribeiro-Varandas
authors.affiliation: Landscape, Environment, Agriculture and Food (LEAF) Centre, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal.
authors.forename: H Sofia
authors.initials: HS
authors.lastname: Pereira
authors.affiliation: Landscape, Environment, Agriculture and Food (LEAF) Centre, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal.
authors.forename: Wanda
authors.initials: W
authors.lastname: Viegas
authors.affiliation: Landscape, Environment, Agriculture and Food (LEAF) Centre, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal; Faculty of Psychology and Life Sciences, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal. Electronic address: mxdelgado@isa.ulisboa.pt.
authors.forename: Margarida
authors.initials: M
authors.lastname: Delgado
mesh_terms: D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D003865:Major Depressive Disorder / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D019073:HT29 Cells; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D010636:Phenols / Q000009:adverse effects / Q000633:toxicity*; D060888:Real-Time Polymerase Chain Reaction; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015415:Biomarkers; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BPA; Gene transcription; HT29; HUVEC; MDD biomarkers