title: [New perspective on the role of WNK1 and WNK4 in the regulation of NaCl reabsorption and K(+) secretion by the distal nephron].
abstract: The study of Familial Hyperkalemic Hypertension (FHHt), a rare monogenic disease, allowed remarkable advances in the understanding of the mechanisms of regulation of NaCl reabsorption by the distal nephron. FHHt results from mutations in the genes encoding WNK1 and WNK4, two serine-threonine kinases of the WNK (With No lysine [K]) family. The clinical manifestations of FHHt are due, among others, to an increased activity of the Na(+)-Cl(-) cotransporter NCC. Several groups therefore tried to understand how WNK1 and WNK4 could regulate NCC. However, the data were often contradictory. Two of our recent studies allowed to partially explain these controversies and to propose a new model for the regulation of NCC by the WNKs.
authors.affiliation: Inserm UMR970, Paris Centre de Recherche cardiovasculaire, 56, rue Leblanc, 75015 Paris, France - Université Paris-Descartes, Sorbonne Paris Cité, Paris, France - Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Rafael
authors.affiliation: Inserm UMR970, Paris Centre de Recherche cardiovasculaire, 56, rue Leblanc, 75015 Paris, France - Université Paris-Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Chavez-Canales
authors.affiliation: Inserm UMR970, Paris Centre de Recherche cardiovasculaire, 56, rue Leblanc, 75015 Paris, France - Université Paris-Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Hadchouel
mesh_terms: D065567:Absorption, Physiological; D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D007686:Kidney Tubules, Distal / Q000378:metabolism; D015778:Minor Histocompatibility Antigens / Q000502:physiology*; D009399:Nephrons / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D012965:Sodium Chloride / Q000378:metabolism*; D064486:Solute Carrier Family 12, Member 3 / Q000502:physiology; D000076204:WNK Lysine-Deficient Protein Kinase 1
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D015778:Minor Histocompatibility Antigens; C578874:SLC12A3 protein, human; D064486:Solute Carrier Family 12, Member 3; D012965:Sodium Chloride; D017346:Protein Serine-Threonine Kinases; D000076204:WNK Lysine-Deficient Protein Kinase 1; C498743:WNK1 protein, human; C433806:WNK4 protein, human; D011188:Potassium