title: Comparative Screening of Digestion Tract Toxic Genes in Proteus mirabilis.
abstract: Proteus mirabilis is a common urinary tract pathogen, and may induce various inflammation symptoms. Its notorious ability to resist multiple antibiotics and to form urinary tract stones makes its treatment a long and painful process, which is further challenged by the frequent horizontal gene transferring events in P. mirabilis genomes. Three strains of P. mirabilis C02011/C04010/C04013 were isolated from a local outbreak of a food poisoning event in Shenzhen, China. Our hypothesis is that new genes may have been acquired horizontally to exert the digestion tract infection and toxicity. The functional characterization of these three genomes shows that each of them independently acquired dozens of virulent genes horizontally from the other microbial genomes. The representative strain C02011 induces the symptoms of both vomit and diarrhea, and has recently acquired a complete type IV secretion system and digestion tract toxic genes from the other bacteria.
authors.affiliation: School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, 510515, China.|Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Shi
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Yiman
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Yaqun
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Qiongcheng
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Yuan
authors.affiliation: School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cao
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Hu
authors.affiliation: School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Shenghe
authors.initials: S
authors.lastname: Huang
mesh_terms: D002681:China / Q000453:epidemiology; D005517:Foodborne Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D005798:Genes, Bacterial; D006801:Humans; D010802:Phylogeny; D011512:Proteus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D011513:Proteus mirabilis / Q000235:genetics* / Q000302:isolation & purification