title: The real cost of sequencing: scaling computation to keep pace with data generation.
abstract: As the cost of sequencing continues to decrease and the amount of sequence data generated grows, new paradigms for data storage and analysis are increasingly important. The relative scaling behavior of these evolving technologies will impact genomics research moving forward.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520, USA.|Systems Biology Institute, Yale University, West Haven, CT, 06516, USA.|Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, CT, 06520, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Muir
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
authors.forename: Shantao
authors.initials: S
authors.lastname: Li
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
authors.forename: Shaoke
authors.initials: S
authors.lastname: Lou
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
authors.forename: Daifeng
authors.initials: D
authors.lastname: Wang
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Spakowicz
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Salichos
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Weinstock
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520, USA.|Systems Biology Institute, Yale University, West Haven, CT, 06516, USA.
authors.forename: Farren
authors.initials: F
authors.lastname: Isaacs
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Rozowsky
authors.affiliation: Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA. mark@gersteinlab.org.|Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA. mark@gersteinlab.org.|Department of Computer Science, Yale University, New Haven, CT, 06520, USA. mark@gersteinlab.org.
authors.forename: Mark
authors.initials: M
authors.lastname: Gerstein
mesh_terms: D000465:Algorithms; D035843:Biomedical Research; D019295:Computational Biology / Q000379:methods / Q000639:trends*; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing / Q000191:economics* / Q000379:methods; D006801:Humans; D016247:Information Storage and Retrieval