title: Gut microbes in correlation with mood: case study in a closed experimental human life support system.
abstract: Gut microbial community, which may influence our mood, can be shaped by modulating the gut ecosystem through dietary strategies. Understanding the gut-brain correlationship in healthy people is important for maintenance of mental health and prevention of mental illnesses.
  
  
  
  A case study on the correlation between gut microbial alternation and mood swing of healthy adults was conducted in a closed human life support system during a 105-day experiment. Gut microbial community structures were analyzed using high-throughput sequencing every 2 weeks. A profile of mood states questionnaire was used to record the mood swings. Correlation between gut microbes and mood were identified with partial least squares discrimination analysis.
  
  
  
  Microbial community structures in the three healthy adults were strongly correlated with mood states. Bacterial genera Roseburia, Phascolarctobacterium, Lachnospira, and Prevotella had potential positive correlation with positive mood, while genera Faecalibacterium, Bifidobacterium, Bacteroides, Parabacteroides, and Anaerostipes were correlated with negative mood. Among which, Faecalibacterium spp. had the highest abundance, and showed a significant negative correlation with mood.
  
  
  
  Our results indicated that the composition of microbial community could play a role in emotional change in mentally physically healthy adults.
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing, China.|Institute of Environmental Biology and Life Support Technology, Beihang University, Beijing, China.|International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing, China.|Institute of Environmental Biology and Life Support Technology, Beihang University, Beijing, China.|International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Su
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing, China.|Institute of Environmental Biology and Life Support Technology, Beihang University, Beijing, China.|International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing, China.
authors.forename: B
authors.initials: B
authors.lastname: Xie
authors.affiliation: Department of Gastroenterology, Peking University Third Hospital, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Duan
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing, China.|Institute of Environmental Biology and Life Support Technology, Beihang University, Beijing, China.|International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing, China.|Institute of Environmental Biology and Life Support Technology, Beihang University, Beijing, China.|International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing, China.
authors.forename: D
authors.initials: D
authors.lastname: Hu
authors.affiliation: Institute of Psychology and Behavior, Beihang University, Beijing, China.
authors.forename: R
authors.initials: R
authors.lastname: Wu
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing, China.|Institute of Environmental Biology and Life Support Technology, Beihang University, Beijing, China.|International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D004777:Environment; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D008021:Life Support Systems; D008297:Male
keywords: Illumina MiSeq; PLS-DA; correlation coefficient; gut microbial community; microbiota-gut-brain axis