title: Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis.
abstract: The neutralization of integrin α4 (Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the CNS, we have uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology. Our study underscores the importance of looking at the dual role of B cells in CNS autoimmunity and provides important perspectives regarding the efficacy and side effects associated with Itga4 neutralization and other B cell-targeting therapies.
authors.affiliation: Immunology Program, Benaroya Research Institute, Seattle, WA 98101; and Department of Immunology, University of Washington, Seattle, WA 98105.
authors.forename: Simon
authors.initials: S
authors.lastname: Glatigny
authors.affiliation: Department of Immunology, University of Washington, Seattle, WA 98105.
authors.forename: Catriona A
authors.initials: CA
authors.lastname: Wagner
authors.affiliation: Immunology Program, Benaroya Research Institute, Seattle, WA 98101; and Department of Immunology, University of Washington, Seattle, WA 98105 ebettelli@benaroyaresearch.org.
authors.forename: Estelle
authors.initials: E
authors.lastname: Bettelli
mesh_terms: D000818:Animals; D060151:B-Lymphocytes, Regulatory / Q000276:immunology* / Q000502:physiology; D002465:Cell Movement; D002490:Central Nervous System / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D039441:Integrin alpha4 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D039441:Integrin alpha4