title: GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line.
abstract: The graphene oxide nanosheets can act as a nanocarrier for the delivery of therapeutic agents. The PEGylated GO has high solubility, good stability, and more biocompatibility in physiological solutions. In this study, the anticancer effects of synthesized GO-PEG as a drug nanocarrier evaluated to estimate the synergistic cytotoxic effect of drugs loaded on this type of nanocarrier and to determine the actual effect of any drugs encapsulated on it. The cytotoxic effects of GO-PEG nanosheets were evaluated on HeLa cell line by MTT assay. The results exhibited cytotoxic property of PEGylated GO drug nanocarrier significantly is dose dependent and incubation time dependent.
authors.affiliation: a Department of Biology , College of science, Yadegar-e-Imam Khomeini(RAH) Shahr-e-rey Branch, Islamic Azad University , Tehran , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Bikhof Torbati
authors.affiliation: b Department of chemistry , College of science, Yadegar-e-Imam Khomeini(RAH) Shahr-e-rey Branch, Islamic Azad University , Tehran , Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Ebrahimian
authors.affiliation: b Department of chemistry , College of science, Yadegar-e-Imam Khomeini(RAH) Shahr-e-rey Branch, Islamic Azad University , Tehran , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yousefi
authors.affiliation: c Department of Chemistry , College of science, Damghan Branch, Islamic Azad University , Damghan , Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Shaabanzadeh
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001692:Biological Transport; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D065546:Drug Liberation; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010087:Oxides; D011092:Polyethylene Glycols; D006108:Graphite
keywords: Anticancer; MTT assay; PEGylated; graphene oxide; nanocarrier