title: Healthy Lifestyle Pattern is Protective Against 30-Yr Cancer Incidence in Men and Women: A Cohort Study.
abstract: OBJECTIVE
  Investigate associations of healthier behaviors with 30-yr cancer incidence.
  
  
  METHODS
  In 1982, 632 healthy men and women (ages 40-70) were interviewed for nutritional habits using a Food Frequency Questionnaire and a 24-h physical activity questionnaire. Blood pressure, weight, and height were measured, and blood was drawn for biochemical profiles. Thirteen and four subjects were excluded due to cancer diagnosis ≤1 yr from recruitment and extreme values of reported total daily calorie intake, respectively.
  
  
  RESULTS
  During a mean follow-up of 24.2 yr, 146 cancer incident patients (23.7%) were documented. Total cancer risk was 38% lower in the medium vegetable intake tertile [adjusted hazards ratio (HR) = 0.62, 95%confidence interval (CI): 0.40-0.95], and 66% higher in the medium fruit intake tertile (adjusted HR = 1.66, 95%CI: 1.08-2.55) compared to the lowest tertile. The risk of gastrointestinal cancers was 3 times greater for the highest, compared to the lowest, dairy consumption tertile (HR = 3.06, 95%CI: 1.01-9.23). "Healthy lifestyle" (normal BMI, never smoked, consuming high levels of dietary fiber and vegetables, and more physically active) reduced overall cancer risk (adjusted HR = 0.63, 95%CI: 0.44-0.91) as compared to the rest of the cohort.
  
  
  CONCLUSIONS
  Our findings reinforce the importance of lifestyle-related factors, which are relatively low-cost and may contribute to reduction in the burden of malignant diseases.
authors.affiliation: a Sackler Faculty of Medicine, School of Public Health , Department of Epidemiology and Preventive Medicine , Tel Aviv University , Ramat Aviv , Tel Aviv , Israel.
authors.forename: Liat
authors.initials: L
authors.lastname: Orenstein
authors.affiliation: b The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center , Israel.
authors.forename: Angela
authors.initials: A
authors.lastname: Chetrit
authors.affiliation: a Sackler Faculty of Medicine, School of Public Health , Department of Epidemiology and Preventive Medicine , Tel Aviv University , Ramat Aviv , Tel Aviv , Israel.|b The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center , Israel.
authors.forename: Rachel
authors.initials: R
authors.lastname: Dankner
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D004043:Dietary Fiber / Q000494:pharmacology; D015444:Exercise; D005247:Feeding Behavior; D005260:Female; D005638:Fruit; D000070497:Healthy Lifestyle; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D011795:Surveys and Questionnaires