title: Blood, blebs and lumen expansion.
abstract: A powerful combination of cell labelling, genetic tools and rapid imaging techniques in vivo has now led to a high-resolution description of lumen formation during angiogenesis in zebrafish. The study reveals a haemodynamic-force-driven and myosin-II-dependent cellular mechanism (termed inverse membrane blebbing) as the basis for lumen expansion in unicellular and multicellular angiogenic sprouts.
authors.affiliation: University of Münster, Institute of Cell Biology, ZMBE, Von-Esmarch-Straβe 56, D-48149 Münster, Germany.
authors.forename: Michal
authors.initials: M
authors.lastname: Reichman-Fried
authors.affiliation: University of Münster, Institute of Cell Biology, ZMBE, Von-Esmarch-Straβe 56, D-48149 Münster, Germany.
authors.forename: Erez
authors.initials: E
authors.lastname: Raz
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000196:embryology*; D005260:Female; D008297:Male; D009024:Morphogenesis; D018919:Neovascularization, Physiologic