title: Sporadic Burkitt's lymphoma/acute B-cell leukaemia presenting with progressive proptosis and orbital mass in a child.
abstract: Burkitt's lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma that is found predominantly in children, with the highest incidence occurring in Africa. The sporadic form occurs in non-endemic areas and typically involves the ileo-caecum and the bowel, whereas orbital and paranasal sinus involvement is rare. Here, we present an unusual case of sporadic BL in a Caucasian male child with rapidly progressive painful proptosis of the right eye. Magnetic resonance imaging showed an oval-shaped, extraconal mass in the supero-lateral part of the right orbit that deformed and dislocated the eyeball antero-inferiorly. The patient underwent anterior orbitotomy, and a biopsy of the excised tissue revealed a starry-sky appearance characteristic of BL. Postoperative aggressive chemotherapy was initiated with a good response after one week.
authors.affiliation: Department of Diagnostic Imaging, Ospedali Riuniti, University of Foggia, Italy daniela.grasso@hotmail.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Grasso
authors.affiliation: Department of Diagnostic Imaging, Ospedali Riuniti, University of Foggia, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Borreggine
authors.affiliation: Department of Paediatric Haematology/Oncology, IRCCS Casa Sollievo della Sofferenza, Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Ladogana
authors.affiliation: Department of Paediatric Haematology/Oncology, IRCCS Casa Sollievo della Sofferenza, Italy.
authors.forename: Raffaela
authors.initials: R
authors.lastname: De Santis
authors.affiliation: Ophthalmology, Ospedali Riuniti, University of Foggia, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Delle Noci
authors.affiliation: Operative Unit of Radiodiagnostics, Ospedali Riuniti, Italy.
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Grilli
authors.affiliation: Department of Diagnostic Imaging, Ospedali Riuniti, University of Foggia, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Macarini
mesh_terms: D002051:Burkitt Lymphoma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D002675:Child, Preschool; D005094:Exophthalmos / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: Burkitt’s lymphoma; magnetic resonance imaging; orbitotomy; paediatric orbital tumour; proptosis