title: Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience.
abstract: Ketamine, a primarily FDA-approved anaesthetic agent is also used as recreational drug. Based on preclinical findings and later the clinical observations it is noted to have rapid antidepressant effect due to its mechanisms related to NMDA antagonism. In spite of established evidence of ketamine being effective in depression with significant role in treatment resistant cases as well, there was absolute dearth of literature regarding its utility in grief-related disorders. In this context we present a case of 28-year-old graduate male who presented to us in complicated grief following death of his wife due to obstetric complications. With the patient and immediate family members consenting for use of ketamine as off-label use, patient had single IV infusion of ketamine following which he had unique phenomenological experience ultimately resolving his grief in few minutes. Through this case we highlight the enormous therapeutic promise of ketamine in complicated grief.
authors.affiliation: Department of Psychiatrist, Spandana Nursing Home, Bangalore, Karnataka, India.
authors.forename: Mahesh Ramanna
authors.initials: MR
authors.lastname: Gowda
authors.affiliation: Department of Psychiatrist, Spandana Nursing Home, Bangalore, Karnataka, India.
authors.forename: Preethi
authors.initials: P
authors.lastname: Srinivasa
authors.affiliation: Clinical Research Coordinator, Spandana Nursing Home, Bangalore, Karnataka, India.
authors.forename: Prabha S
authors.initials: PS
authors.lastname: Kumbar
authors.affiliation: DNB Resident, Spandana Nursing Home, Bangalore, Karnataka, India.
authors.forename: Vinay Hosagavi
authors.initials: VH
authors.lastname: Ramalingaiah
authors.affiliation: Department of Psychiatrist, Spandana Nursing Home, Bangalore, Karnataka, India.
authors.forename: Chandrashekar
authors.initials: C
authors.lastname: Muthyalappa
authors.affiliation: DNB Resident, Spandana Nursing Home, Bangalore, Karnataka, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Durgoji
keywords: Antidepressant; grief; ketamine; rapid resolution