title: An integrated interface for peripheral neural system recording and stimulation: system design, electrical tests and in-vivo results.
abstract: The prototype of an electronic bi-directional interface between the Peripheral Nervous System (PNS) and a neuro-controlled hand prosthesis is presented. The system is composed of 2 integrated circuits: a standard CMOS device for neural recording and a HVCMOS device for neural stimulation. The integrated circuits have been realized in 2 different 0.35μ m CMOS processes available from ams. The complete system incorporates 8 channels each including the analog front-end, the A/D conversion, based on a sigma delta architecture and a programmable stimulation module implemented as a 5-bit current DAC; two voltage boosters supply the output stimulation stage with a programmable voltage scalable up to 17V. Successful in-vivo experiments with rats having a TIME electrode implanted in the sciatic nerve were carried out, showing the capability of recording neural signals in the tens of microvolts, with a global noise of 7μ V r m s , and to selectively elicit the tibial and plantar muscles using different active sites of the electrode.
authors.affiliation: Università di Cagliari, Cagliari, Italy. caterina.carboni@diee.unica.it.
authors.forename: Caterina
authors.initials: C
authors.lastname: Carboni
authors.affiliation: Università di Cagliari, Cagliari, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bisoni
authors.affiliation: Università di Cagliari, Cagliari, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Carta
authors.affiliation: Università di Cagliari, Cagliari, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Puddu
authors.affiliation: École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Stanisa
authors.initials: S
authors.lastname: Raspopovic
authors.affiliation: Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Navarro
authors.affiliation: Università di Cagliari, Cagliari, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Raffo
authors.affiliation: Università di Cagliari, Cagliari, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Barbaro
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods*; D004560:Electricity; D004567:Electrodes, Implanted; D004867:Equipment Design; D008670:Metals / Q000737:chemistry; D058117:Neural Prostheses; D010087:Oxides / Q000737:chemistry; D017933:Peripheral Nervous System / Q000502:physiology*; D051381:Rats; D012666:Semiconductors
chemical_list: D008670:Metals; D010087:Oxides
keywords: Bioelectronic devices; Multi-channel neural recording; Neural stimulation