title: How drug resistance takes shape.
abstract: Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.
authors.affiliation: Center for Functional Cancer Epigenetics and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States.|Department of Medicine, Harvard Medical School, Boston, United States.
authors.forename: Rinath
authors.initials: R
authors.lastname: Jeselsohn
authors.affiliation: Center for Functional Cancer Epigenetics and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States.|Department of Medicine, Harvard Medical School, Boston, United States.
authors.forename: Myles
authors.initials: M
authors.lastname: Brown
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D011960:Receptors, Estrogen / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*
chemical_list: D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators
keywords: acquired drug resistance; biophysics; breast cancer; estrogen receptor alpha; hormone; human; human biology; medicine; selective estrogen receptor modulators; somatic mutation; structural biology