title: Leucocyte Membrane-Coated Janus Microcapsules for Enhanced Photothermal Cancer Treatment.
abstract: Polyelectrolyte multilayer (PEM) capsules are promising candidates for many kinds of cancer detection and treatment but are usually intended to deliver cargo to specific sites or to destroy cancer cells based on photothermal effects from the outside. In this publication we prove that it is possible to kill cancer cells from the inside based on phagocytosed PEM capsules. In addition we show how to open the cells and bring the PEM capsules to the surface of cancer cells based on photothermal effects and rapid evaporation of water. Diffusion-based temperature determinations of the photothermal effect up to the evaporation temperature of water are presented.
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Yi Kuang Street 2, Harbin 150080, China.
authors.forename: Wenping
authors.initials: W
authors.lastname: He
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Yi Kuang Street 2, Harbin 150080, China.
authors.forename: Johannes
authors.initials: J
authors.lastname: Frueh
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Yi Kuang Street 2, Harbin 150080, China.
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Yi Kuang Street 2, Harbin 150080, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
mesh_terms: D000327:Adsorption; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D002214:Capsules; D002232:Carbocyanines / Q000737:chemistry; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D009000:Monocytes / Q000737:chemistry*; D010587:Phagocytosis; D010789:Phototherapy; D011073:Polyamines / Q000737:chemistry; D000071228:Polyelectrolytes / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D011419:Propidium / Q000737:chemistry
chemical_list: C576569:1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine; D000970:Antineoplastic Agents; D002214:Capsules; D002232:Carbocyanines; D005456:Fluorescent Dyes; D011073:Polyamines; D000071228:Polyelectrolytes; D011137:Polystyrenes; C063994:polyallylamine; D011419:Propidium; C003321:polystyrene sulfonic acid; D006046:Gold