title: A Self-Assembled Metallomacrocycle Singlet Oxygen Sensitizer for Photodynamic Therapy.
abstract: Although metal-ion-directed self-assembly has been widely used to construct a vast number of macrocycles and cages, it is only recently that the biological properties of these systems have begun to be explored. However, up until now, none of these studies have involved intrinsically photoexcitable self-assembled structures. Herein we report the first metallomacrocycle that functions as an intracellular singlet oxygen sensitizer. Not only does this Ru2 Re2 system possess potent photocytotoxicity at light fluences below those used for current medically employed systems, it offers an entirely new paradigm for the construction of sensitizers for photodynamic therapy.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Walker
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Jarman
authors.affiliation: Department of Biomedical Science, University of Sheffield, Sheffield, UK.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Gill
authors.affiliation: Department of Chemistry, University College London, London, UK.
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Malaysia.
authors.forename: Haslina
authors.initials: H
authors.lastname: Ahmad
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK.
authors.forename: Pattubala A N
authors.initials: PA
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK.
authors.forename: Luke
authors.initials: L
authors.lastname: McKenzie
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Weinstein
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK.
authors.forename: Anthony J H M
authors.initials: AJ
authors.lastname: Meijer
authors.affiliation: Department of Chemistry, University College London, London, UK.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Battaglia
authors.affiliation: Department of Biomedical Science, University of Sheffield, Sheffield, UK. c.g.w.smythe@sheffield.ac.uk.
authors.forename: Carl G W
authors.initials: CG
authors.lastname: Smythe
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK. james.thomas@sheffield.ac.uk.
authors.forename: Jim A
authors.identifier: http://orcid.org/0000-0002-8662-7917
authors.initials: JA
authors.lastname: Thomas
mesh_terms: D009942:Organometallic Compounds / Q000737:chemistry*; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D026082:Singlet Oxygen
keywords: luminescence; photodynamic therapy; ruthenium; self-assembly; singlet oxygen