title: Silver(I)-Mediated Phosphorylation/Cyclization Cascade of N-Cyanamide Alkenes for Divergent Access to Quinazolinones and Dihydroisoquinolinones.
abstract: A silver(I)-mediated phosphorylation/cyclization radical cascade of N-cyanamide alkenes has been developed. The addition of in situ generated phosphorus radical to N-cyanamide alkenes triggers the cascade, resulting in late-stage cyclization toward divergent access to 4-quinazolinones and dihydroisoquinolinones. Both terminal and internal N-cyanamide alkenes are applicable in this protocol, and the cyclizations are consistent with Baldwin's rule.
authors.affiliation: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China.
authors.forename: Dahai
authors.initials: D
authors.lastname: Wang
authors.affiliation: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China.
authors.forename: Sunliang
authors.initials: S
authors.lastname: Cui
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003484:Cyanamide / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D010766:Phosphorylation; D052999:Quinazolinones / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D000475:Alkenes; D052999:Quinazolinones; D012834:Silver; D003484:Cyanamide