title: Sepsis patients' renal manifestation on contrast-enhanced CT.
abstract: OBJECTIVE
  To evaluate renal volume and attenuation changes in patients with sepsis on contrast-enhanced computed tomography (CT) with respect to the severity of sepsis.
  
  
  METHODS
  Forty-four patients with sepsis who underwent CT before and after the onset of sepsis were retrospectively analysed. Renal volume and CT attenuation value of the renal cortex on contrast-enhanced CT were measured for each patient and changes in renal volume and CT attenuation value from before to after the onset of sepsis were calculated. The changes were correlated with the severity of sepsis (Sepsis-related Organ Failure Assessment [SOFA] score). The time course of the renal volume and CT attenuation changes were also evaluated.
  
  
  RESULTS
  Renal volume increased by 17.6% and CT attenuation value decreased by 19% after the onset of sepsis with statistically significant differences (p<0.001 for both renal volume and CT attenuation changes). The renal volume and CT attenuation changes had significant correlations with the SOFA score (r=0.36, p=0.018 and -0.43, p=0.005, respectively). The time course of the renal volume and CT attenuation changes seemed to be gradual compared to that of the SOFA score and to lag behind the peak of the SOFA score.
  
  
  CONCLUSIONS
  In patients with sepsis, the renal volume increases and the CT attenuation value decreases in proportion to the severity of sepsis. The changes may lag behind the peak of severity of sepsis and can be observed for a relatively long time after a patient's recovery from sepsis.
authors.affiliation: Department of Radiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan. Electronic address: k.sasaguri@gmail.com.
authors.forename: K
authors.initials: K
authors.lastname: Sasaguri
authors.affiliation: Department of Radiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.affiliation: Department of Radiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakazono
authors.affiliation: Department of Radiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mizuguchi
authors.affiliation: Department of Radiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Irie
mesh_terms: D058186:Acute Kidney Injury / Q000000981:diagnostic imaging* / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007668:Kidney / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000150:complications / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media