title: The Rotavirus Interferon Antagonist NSP1: Many Targets, Many Questions.
abstract: Rotavirus is a leading cause of death due to diarrhea among young children across the globe. Despite the limited coding capacity that is characteristic of RNA viruses, rotavirus dedicates substantial resources to avoiding the host innate immune response. Among these strategies is use of the interferon antagonist protein NSP1, which targets cellular proteins required for interferon production to be degraded by the proteasome. Although numerous cellular targets have been described, there remain many questions about the mechanism of NSP1 activity and its role in promoting replication in specific host species.
authors.affiliation: Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA marno2@lsuhsc.edu.
authors.forename: Michelle M
authors.identifier: http://orcid.org/0000-0001-9219-3097
authors.initials: MM
authors.lastname: Arnold
mesh_terms: D000818:Animals; D058507:Host Specificity; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D059748:Proteolysis; D012401:Rotavirus / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D012400:Rotavirus Infections / Q000276:immunology / Q000821:virology*; D015398:Signal Transduction; D017361:Viral Nonstructural Proteins / Q000502:physiology*
chemical_list: D017361:Viral Nonstructural Proteins; C104282:nsp1 protein, Rotavirus; D007372:Interferons; D046988:Proteasome Endopeptidase Complex