title: Audiogenic epilepsy and GABAergic system of the colliculus inferior in Krushinsky-Molodkina rats.
abstract: GABAergic brain system is an important link in the pathological circuits of rodent audiogenic epilepsy (AE). The number of GABAergic neurons in the inferior colliculi of KM strain rats (AE prone) was not different from that of the control non-prone strain. At the same time, the glutamate decarboxylase mRNA expression (the key enzyme of GABA synthesis) was 5 times higher than in control. The data evidence that the GABAergic system does play an important role in AE proneness.
authors.affiliation: Biological Faculty, Moscow State University, Moscow, 119991, Russia.
authors.forename: G M
authors.initials: GM
authors.lastname: Solius
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia. ingapoletaeva@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Revishchin
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Pavlova
authors.affiliation: Biological Faculty, Moscow State University, Moscow, 119991, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Poletaeva
mesh_terms: D000818:Animals; D020195:Epilepsy, Reflex / Q000378:metabolism*; D059330:GABAergic Neurons / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D007245:Inferior Colliculi / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats
chemical_list: D012333:RNA, Messenger; D005968:Glutamate Decarboxylase