title: High-sensitivity cardiac troponin T in geriatric inpatients.
abstract: High-sensitivity cardiac troponin T (hs-cTnT) is detectable in elderly patients without clinical diagnosed cardiovascular disease. Elevated hs-cTnT levels predict increased cardiovascular risks and poor prognosis. The aim of this study was to determine the distribution and associated factors of hs-cTnT in geriatric inpatients without acute coronary syndrome (ACS).
  
  
  
  Hs-cTnT was measured with a highly sensitive assay in 679 geriatric inpatients without ACS. Patients were further divided into 3 groups according to the tertile of hs-cTnT levels and single and multiple variable analyses were performed to assess the association of hs-cTnT to cardiovascular risk factors, biochemical measurements and echocardiographic abnormalities.
  
  
  
  Hs-cTnT was detectable (≥3ng/L) in 98.4% of the subjects and 52.0% of the subjects had hs-cTnT levels ≥14ng/L, which is at the 99th percentile Upper Reference Limit (URL). The levels of hs-cTnT were independently associated with N-terminal pro-brain natriuretic peptide (NT-proBNP), male gender, older age, estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), diabetes mellitus (DM) and left ventricular ejection fraction (LVEF). There were no significant differences in hs-cTnT levels between geriatrics patients with stable coronary artery disease (SCAD) and those without SCAD.
  
  
  
  Hs-cTnT elevation caused by non-ischemic acute conditions was very common in geriatric hospitalized patients. Due to increases in baseline hs-cTnT in the elderly, detection of a rise and/or fall in hs-cTnT levels is essential for determining a diagnosis of ACS or AMI in geriatric patients. Further studies are needed to establish age-specific 99th percentile values of hs-cTnT for elderly individuals.
authors.affiliation: Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Shao-Jing
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China. Electronic address: wq1122@medmail.com.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Yun-Jing
authors.initials: YJ
authors.lastname: Cui
authors.affiliation: Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Zhao
authors.affiliation: Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D008297:Male; D012307:Risk Factors; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T
keywords: ACS; Geriatric inpatients; High-sensitivity cardiac troponin T; Related factors