title: Case-control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians.
abstract: The rennin-angiotensin-aldosterone system (RAAS) is a critical pathway in regulating blood pressure and salt/water homeostasis, possessing an intimate relationship with the development of systemic artery hypertension (SAH). Once hypertension is considered a risk factor for coronary artery disease (CAD), the RAAS is also related to this pathology. This investigation aimed to analyse if the frequencies of AGT M235T (rs699) and ACE I/D (rs4646994) polymorphisms are associated with CAD and SAH in African-Brazilians and Caucasian-Brazilians. In this study we analysed 714 subjects who underwent coronary angiography to detect obstructive lesions and CAD, as well as blood pressure measurement and SAH, grouped according to ethnicity: 266 African-Brazilians and 448 Caucasian-Brazilians. Among CAD and SAH cases and controls, the genotype and allele frequencies of ACE I/D polymorphism were similar in both ethnic groups. The AGT 235TT genotype and 235T allele frequencies were higher in SAH cases (32%, 54.7%) versus controls in Caucasian-Brazilians (19.8%, 46.4%; P = 0.038, P = 0.031, respectively). The AGT 235TT (OR = 1.8; P = 0.028) demonstrated to be an independent factor risk in a multivariate logistic regression increasing SAH risk in Caucasians but not in African-Brazilians. In summary, AGT M235T polymorphism was associated with SAH risk in Caucasian-Brazilians, and no association was detected with CAD. No association was also observed in ACE I/D polymorphism either in CAD or SAH in African-Brazilians and Caucasian-Brazilians.
authors.affiliation: Department of Biological Sciences, University of Southwest of Bahia, Campus Jequi₂, Rua Jos₂ Moreira Sobrinho, s/n, Jequiezinho, 45200-000, Jequi₂, Bahia, Brazil.domingosrios@hotmail.com.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bonfim-Silva
authors.forename: Larissa Oliveira
authors.initials: LO
authors.lastname: Guimarães
authors.forename: Jandson
authors.initials: J
authors.lastname: Souza Santos
authors.forename: Jaqueline Fagundes
authors.initials: JF
authors.lastname: Pereira
authors.forename: Ana Angélica
authors.initials: AA
authors.lastname: Leal Barbosa
authors.forename: Domingos Lazaro
authors.initials: DL
authors.lastname: Souza Rios
mesh_terms: D000328:Adult; D000808:Angiotensinogen / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D001938:Brazil; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*
chemical_list: D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A