title: Hypertension, Blood Pressure Variability, and Target Organ Lesion.
abstract: Hypertensive patients have a higher risk of developing health complications, particularly cardiovascular (CV) events, than individuals with normal blood pressure (BP). Severity of complications depends on the magnitude of BP elevation and other CV risk factors associated with the target organ damage. Therefore, BP control and management of organ damage may contribute to reduce this risk. BP variability (BPV) has been considered a physiological marker of autonomic nervous system control and may be implicated in increased CV risk in hypertension. This review will present some evidence relating BPV and target organ damage in hypertension in clinical and experimental settings.
authors.affiliation: Hypertension Unit, Heart Institute (InCor), School of Medicine, University of Sao Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, 05403-900, São Paulo, SP, Brazil. hipirigoyen@incor.usp.br.
authors.forename: Maria-Cláudia
authors.initials: MC
authors.lastname: Irigoyen
authors.affiliation: Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.
authors.forename: Kátia
authors.initials: K
authors.lastname: De Angelis
authors.affiliation: Hypertension Unit, Heart Institute (InCor), School of Medicine, University of Sao Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, 05403-900, São Paulo, SP, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Dos Santos
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/ Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, RS, Brazil.
authors.forename: Daniela R
authors.initials: DR
authors.lastname: Dartora
authors.affiliation: Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Rodrigues
authors.affiliation: Hypertension Unit, Heart Institute (InCor), School of Medicine, University of Sao Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, 05403-900, São Paulo, SP, Brazil.|Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.
authors.forename: Fernanda Marciano
authors.initials: FM
authors.lastname: Consolim-Colombo
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000503:physiopathology; D001794:Blood Pressure; D001795:Blood Pressure Determination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents
keywords: Autonomic dysfunction; Blood pressure variability; Hypertension; Target-organ damage