title: Breast Cancer Risk Variants Affect Estrogen Receptor.
abstract: Researchers have discovered five risk variants for breast cancer that lie in the vicinity of the gene that codes for the estrogen receptor. Four of the variants occur within enhancer regions and reduce expression of the receptor, and the fifth is in a silencer region and increases expression.
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D011960:Receptors, Estrogen / Q000235:genetics* / Q000378:metabolism*; D012306:Risk
chemical_list: D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen