title: The Use of Dental Implants in Organ Transplant Patients Undergoing Immunosuppressive Therapy: An Overview of Publications.
abstract: BACKGROUND
  Immunosuppressive treatment has been commonly considered a contraindication to the use of dental implants. This article is aimed at analyzing the publications related to that issue and answering the question of whether such treatment is viable in patients with organ transplants.
  
  
  METHODS
  The following databases have been searched to find related publications: Clinical Key, Web of Science, Up to date, PubMed, and Medline. Full research paper texts published over the past 15 years have been taken into consideration. The selected publications were divided depending on the type of study material, that is, whether they focused on animal tests or human tests.
  
  
  RESULTS
  The studies performed on animals showed negative impact of immunosuppression on the bones surrounding the implants. Publications presenting clinical cases of organ transplant patients indicated no significant disorders in the process of implant osseointegration despite the use of immunosuppressive drugs.
  
  
  CONCLUSIONS
  Despite the negative impact of immunosuppressive drugs on the process of bone healing, it is possible to treat organ transplant patients with intraosseous titanium implants. The key to success is the observance of appropriate treatment procedures and proper hygienic routines. An alteration of medication regimen that currently makes use of immunosuppressive drugs of much lower toxicity is also extremely significant.
authors.affiliation: *PhD Student, Department of Maxillofacial Surgery, Poznan University of Medical Sciences, Poznan, Poland. †Professor, Department of Maxillofacial Surgery, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Radzewski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Osmola
mesh_terms: D000075202:Contraindications; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016377:Organ Transplantation
chemical_list: D015921:Dental Implants; D007166:Immunosuppressive Agents