title: Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
abstract: Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
authors.affiliation: Department of Infectious Disease Infection Control and Employee Health , MD Anderson Cancer Center , Houston, Texas.
authors.forename: Jessica
authors.initials: J
authors.lastname: Galloway-Peña
authors.affiliation: Division of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.
authors.forename: Meredith E
authors.initials: ME
authors.lastname: Clement
authors.affiliation: Division of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.
authors.forename: Batu K
authors.initials: BK
authors.lastname: Sharma Kuinkel
authors.affiliation: Division of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.
authors.forename: Felicia
authors.initials: F
authors.lastname: Ruffin
authors.affiliation: Section of Infectious Diseases, Department of Pediatrics , Baylor College of Medicine and Texas Children's Hospital , Houston.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Flores
authors.affiliation: Departments of Surgery, Dermatology, and Pathology , Duke University Medical Center , Durham.
authors.forename: Howard
authors.initials: H
authors.lastname: Levinson
authors.affiliation: Department of Infectious Disease Infection Control and Employee Health , MD Anderson Cancer Center , Houston, Texas.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Shelburne
authors.affiliation: North Carolina Department of Health and Human Services, Raleigh.
authors.forename: Zack
authors.initials: Z
authors.lastname: Moore
authors.affiliation: Division of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.
authors.forename: Vance G
authors.initials: VG
authors.lastname: Fowler
keywords: Streptococcuspyogenes; group A Streptococcus; invasive disease; speB; whole-genome sequencing