title: Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex.
abstract: Recently, a single nucleotide polymorphism (SNP) in the CAMKK2 gene (rs1063843) was found to be associated with lower expression of the gene in the dorsolateral prefrontal cortex (DLPFC) and with schizophrenia (SCZ) and deficits in working memory and executive function. However, the brain mechanism underlying this association is poorly understood. A functional magnetic resonance imaging (fMRI) study (N = 84 healthy volunteers) involving multiple cognitive tasks, including a Stroop task (to measure attentional executive control), an N-back task (to measure working memory), and a delay discounting task (to measure decision making) to identify the brain regions affected by rs1063843 was performed. Across all three tasks, it was found that carriers of the risk allele consistently exhibited increased activation of the left DLPFC. In addition, the risk allele carriers also exhibited increased activation of the right DLPFC and the left cerebellum during the Stroop task and of the left caudate nucleus during the N-back task. These findings helped to elucidate the role of CAMKK2 in cognitive functions and in the etiology of SCZ. Hum Brain Mapp 37:2398-2406, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Xiongying
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining, Shandong Province, 272013, People's Republic of China.
authors.forename: Qiumei
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Bingqian
authors.initials: B
authors.lastname: Han
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining, Shandong Province, 272013, People's Republic of China.
authors.forename: Jinguo
authors.initials: J
authors.lastname: Zhai
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining, Shandong Province, 272013, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Boqi
authors.initials: B
authors.lastname: Du
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Deng
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining, Shandong Province, 272013, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ji
authors.affiliation: Beijing Anding Hospital, Beijing, 100088, China.
authors.forename: Chuanyue
authors.initials: C
authors.lastname: Wang
authors.affiliation: Beijing Anding Hospital, Beijing, 100088, China.|Faculty of Health Sciences, University of Macau, Taipa, Macau.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Xiang
authors.affiliation: Center for Cognitive Neuroscience, Duke University, Durham, North Carolina, 27701.
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.affiliation: Shengli Hospital of Shengli Petroleum Administration Bureau, Dongying, Shandong Province, 257022, People's Republic of China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Psychology and Social Behavior, University of California, Irvine, California, 92697.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Chen
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase / Q000235:genetics*; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000502:physiology; D065786:Delay Discounting / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009500:Neutralization Tests; D020641:Polymorphism, Single Nucleotide; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D012559:Schizophrenia / Q000235:genetics
chemical_list: C517698:CAMKK2 protein, human; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase
keywords: CAMKK2; cognitive function; dorsolateral prefrontal cortex; functional magnetic resonance imaging; schizophrenia; striatum