title: Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components.
abstract: Metabolic syndrome (MetS) has been found to be associated with inflammatory molecules. This study was conducted among 125 MetS patients at B P Koirala Institute of Health Sciences, Dharan, Nepal to find an association of high-sensitivity C-reactive protein (hs-CRP) and serum uric acid with MetS components. Anthropometric measurements, blood pressure, medical history and blood samples were taken. Estimation of hs-CRP, serum uric acid, blood glucose, triglyceride and high density lipoprotein (HDL) cholesterol was done. hs-CRP had positive correlation with blood glucose (r = 0.2, p = 0.026) and negative with HDL cholesterol (r = -0.361, p < 0.001). Serum uric acid had positive correlation with waist circumference (r = 0.178, p = 0.047). Patients with elevated hs-CRP and uric acid had higher waist circumference (p = 0.03), diastolic BP (p = 0.002) and lower HDL cholesterol (p = 0.004) than others. Elevated hs-CRP and high uric acid were individually associated with higher odds for low HDL cholesterol (7.992; 1.785-35.774, p = 0.002) and hyperglycemia (2.471; 1.111-5.495, p = 0.029) respectively. Combined rise of hs-CRP and uric acid was associated with severity of MetS (p < 0.001) and higher odds for hyperglycemia (8.036; 2.178-29.647, p = 0.001) as compared to individual rise of hs-CRP or uric acid. The present study demonstrates that hs-CRP and serum uric acid are associated with MetS components, and the combined rise of hs-CRP and uric acid is associated with the increase in severity of MetS.
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Sah
authors.affiliation: Department of Biochemistry, Modern Technical College, Sanepa, Lalitpur, Nepal.
authors.forename: Saroj
authors.initials: S
authors.lastname: Khatiwada
authors.affiliation: Department of Biochemistry, B P Koirala Institute of Health Sciences, Dharan, Nepal.
authors.forename: Sunil
authors.initials: S
authors.lastname: Pandey
authors.affiliation: Department of Biochemistry, Modern Technical College, Sanepa, Lalitpur, Nepal.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Kc
authors.affiliation: Department of Biochemistry, B P Koirala Institute of Health Sciences, Dharan, Nepal.
authors.forename: Binod Kumar Lal
authors.initials: BK
authors.lastname: Das
authors.affiliation: Department of Biochemistry, B P Koirala Institute of Health Sciences, Dharan, Nepal.
authors.forename: Nirmal
authors.initials: N
authors.lastname: Baral
authors.affiliation: Department of Biochemistry, B P Koirala Institute of Health Sciences, Dharan, Nepal.
authors.forename: Madhab
authors.initials: M
authors.lastname: Lamsal
keywords: High-sensitivity C-reactive protein; Metabolic syndrome; Nepal; Uric acid