title: Unmasking targets of antitumor immunity via high-throughput antigen profiling.
abstract: More than three decades of evidence has established that antitumor immune responses, initially shown with IL-2 treatment, can result in complete, durable eradication of malignant disease in metastatic patients. Recent studies have demonstrated that immune checkpoint blockade as well as cellular therapies, including dendritic cell activation of T cells and adoptive T cell transfer, can induce long-lasting responses. To elicit cytolysis of tumor cells, effector T cells rely on tumor expression of target antigens. However, the antigens targeted during antitumor responses are largely unknown. Technological advancements and availability of sequencing data have paved the way for more efficient screening and validation of tumor-associated antigens and neoantigens derived from non-synonymous mutations targeted by T cells under baseline conditions and in the context of immunotherapy.
authors.affiliation: Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY, United States. Electronic address: sebastiano.battaglia@roswellpark.org.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Battaglia
authors.affiliation: Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, United States. Electronic address: jason.muhitch@roswellpark.org.
authors.forename: Jason B
authors.initials: JB
authors.lastname: Muhitch
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000276:immunology*; D056726:Genetic Association Studies; D057166:High-Throughput Screening Assays / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D060847:Metabolic Engineering / Q000379:methods / Q000639:trends; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology; D019139:Tumor Escape / Q000235:genetics / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm