title: Short-term effects of repetitive transcranial magnetic stimulation on sleep bruxism - a pilot study.
abstract: The purpose of this study was to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on patients with sleep bruxism (SB). Twelve patients with SB were included in an open, single-intervention pilot study. rTMS at 1 Hz and an intensity of 80% of the active motor threshold was applied to the 'hot spot' of the masseter muscle representation at the primary motor cortex bilaterally for 20 min per side each day for 5 consecutive days. The jaw-closing muscle electromyographic (EMG) activity during sleep was recorded with a portable EMG recorder at baseline, during rTMS treatment and at follow-up for 5 days. In addition, patients scored their jaw-closing muscle soreness on a 0-10 numerical rating scale (NRS). Data were analysed with analysis of variance. The intensity of the EMG activity was suppressed during and after rTMS compared to the baseline (P = 0.04; P = 0.02, respectively). The NRS score of soreness decreased significantly during and after rTMS compared with baseline (P < 0.01). These findings indicated a significant inhibition of jaw-closing muscle activity during sleep along with a decrease of muscle soreness. This pilot study raises the possibility of therapeutic benefits from rTMS in patients with bruxism and calls for further and more controlled studies.
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Orofacial Pain and Temporo-mandibular Disorders Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Zhou
authors.affiliation: Department of Rehabilitation, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Fu
authors.affiliation: Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Yi-Fei
authors.initials: YF
authors.lastname: Du
authors.affiliation: Department of Rehabilitation, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Sun
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Orofacial Pain and Temporo-mandibular Disorders Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Jing-Lu
authors.initials: JL
authors.lastname: Zhang
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Orofacial Pain and Temporo-mandibular Disorders Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Section of Clinical Oral Physiology, School of Dentistry, Aarhus University, Aarhus, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Svensson
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Orofacial Pain and Temporo-mandibular Disorders Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.|Center for Sensory-Motor Interaction (SMI), Aalborg University, Aalborg, Denmark.
authors.forename: Ke-Lun
authors.initials: KL
authors.lastname: Wang
mesh_terms: D000328:Adult; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008406:Masseter Muscle / Q000503:physiopathology; D010865:Pilot Projects; D020186:Sleep Bruxism / Q000503:physiopathology / Q000628:therapy*; D011795:Surveys and Questionnaires; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome