title: Genetic Characterization of a Novel Mutant of Peste Des Petits Ruminants Virus Isolated from Capra ibex in China during 2015.
abstract: Peste des petits ruminants virus (PPRV) is the causative agent of peste des petits ruminants (PPR). The spread of PPR often causes severe economic losses. Therefore, special attention should be paid to the surveillance of PPR emergence, spread, and geographic distribution. Here we describe a novel mutant of PPRV China/XJBZ/2015 that was isolated from Capra ibex in Xinjiang province in China 2015. The sequence analysis and phylogenetic assessment indicate that China/XJBZ/2015 belongs to lineage IV, being closely related to China/XJYL/2013 strain. Interestingly, the V protein sequence of China/XJBZ/2015 showed lower homology with other Chinese PPRVs isolated during 2013 to 2014 (94%~95%), whereas it shared 100% identity with three Tibet strains isolated in China 2007. The 3' UTR, V gene, and C gene were determined to be highly variable. Besides, 29 PPR genomic sequences available in GenBank were analyzed in this study. It is the first time to use PPRV genomic sequences to classify the different lineages which confirmed the lineage clustering of PPRVs using N gene 255 bp fragments and F gene 322 bp fragments. In conclusion, our findings indicate that the PPRVs continue to evolve in China, and some new mutations have emerged.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
authors.forename: Zixiang
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Institute of Veterinary Medicine, Xinjiang Academy of Animal Science, Urumqi, Xinjiang 830000, China.
authors.forename: Xiaocui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Wildlife Epidemics and Epidemic Sources Monitoring Center of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang 830000, China.
authors.forename: Gulizhati
authors.initials: G
authors.lastname: Adili
authors.affiliation: Institute of Veterinary Medicine, Xinjiang Academy of Animal Science, Urumqi, Xinjiang 830000, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Du
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
authors.forename: Xiangle
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.affiliation: China Animal Health and Epidemiology Center, Qingdao, Shandong 266000, China.
authors.forename: Xueguang
authors.initials: X
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
authors.forename: Xiangtao
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
authors.forename: Haixue
authors.initials: H
authors.lastname: Zheng
authors.affiliation: China Institute of Veterinary Drugs Control, Beijing 100000, China.
authors.forename: Qinghong
authors.initials: Q
authors.lastname: Xue
mesh_terms: D000818:Animals; D006041:Goats / Q000821:virology*; D009154:Mutation; D029021:Peste-des-Petits-Ruminants / Q000235:genetics*; D018107:Peste-des-petits-ruminants virus / Q000235:genetics* / Q000302:isolation & purification; D014760:Viral Fusion Proteins / Q000235:genetics*
chemical_list: D014760:Viral Fusion Proteins