title: Monocyte-mediated defense against bacteria, fungi, and parasites.
abstract: Circulating blood monocytes are a heterogeneous leukocyte population that contributes critical antimicrobial and regulatory functions during systemic and tissue-specific infections. These include patrolling vascular tissue for evidence of microbial invasion, infiltrating peripheral tissues and directly killing microbial invaders, conditioning the inflammatory milieu at sites of microbial tissue invasion, and orchestrating the activation of innate and adaptive immune effector cells. The central focus of this review is the in vivo mechanisms by which monocytes and their derivative cells promote microbial clearance and immune regulation. We include an overview of murine models to examine monocyte functions during microbial challenges and review our understanding of the functional roles of monocytes and their derivative cells in host defense against bacteria, fungi, and parasites.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: gregoire.lauvau@einstein.yu.edu.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Lauvau
authors.affiliation: Department of Microbiology, New York University School of Medicine, New York, NY, United States. Electronic address: png.loke@nyumc.org.
authors.forename: P'ng
authors.initials: P
authors.lastname: Loke
authors.affiliation: Infectious Disease Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cencer Center, New York, NY, United States. Electronic address: hohlt@mskcc.org.
authors.forename: Tobias M
authors.initials: TM
authors.lastname: Hohl
mesh_terms: D000818:Animals; D001419:Bacteria; D005658:Fungi; D006801:Humans; D007113:Immunity, Innate; D009000:Monocytes / Q000276:immunology*; D010271:Parasites
keywords: Bacterium; Fungus; Inflammation; Innate immunity; Monocyte; Parasite