title: The antitumor effect of magnetic nanodisks and DNA aptamer conjugates.
abstract: Here we describe a method of forming large arrays (up to 10(9) pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells.
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 13, Novosibirsk, 630090, Russia.
authors.forename: P D
authors.initials: PD
authors.lastname: Kim
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia.|Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Zamay
authors.affiliation: Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia. tzamay@yandex.ru.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia. tzamay@yandex.ru.
authors.forename: T N
authors.initials: TN
authors.lastname: Zamay
authors.affiliation: Astaf'ev Krasnoyarsk State Pedagogical University, ul. A. Lebedevoi 89, Krasnoyarsk, 660049, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Prokopenko
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Kolovskaya
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia.
authors.forename: G S
authors.initials: GS
authors.lastname: Zamay
authors.affiliation: Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 13, Novosibirsk, 630090, Russia.
authors.forename: V Ya
authors.initials: VY
authors.lastname: Princ
authors.affiliation: Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 13, Novosibirsk, 630090, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Seleznev
authors.affiliation: Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 13, Novosibirsk, 630090, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Komonov
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Spivak
authors.affiliation: Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.|Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia.
authors.forename: R Yu
authors.initials: RY
authors.lastname: Rudenko
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Dubinina
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Komarov
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Denisenko
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Komarova
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Sokolov
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Narodov
authors.affiliation: Astaf'ev Krasnoyarsk State Pedagogical University, ul. A. Lebedevoi 89, Krasnoyarsk, 660049, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Zjivaev
authors.affiliation: Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.|Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia.|Institute of Chemistry and Chemical Technology, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Zamay
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D052157:Aptamers, Nucleotide / Q000008:administration & dosage* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry; D060526:Magnetic Fields; D008297:Male; D053768:Metal Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D009532:Nickel / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D052157:Aptamers, Nucleotide; D006046:Gold; D009532:Nickel