title: Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse.
abstract: The medullary vagal motor nuclei, the nucleus ambiguus (NA) and dorsal motor nucleus of the vagus (DMV), innervate the respiratory and gastrointestinal tracts. We conducted immunohistochemical analysis of expression of the androgen receptor (AR) and estrogen receptor α (ERα), in relation to innervation of the trachea and esophagus via vagal motor nuclei in mice. AR and ERα were expressed in the rostral NA and in part of the DMV. Tracing experiments using cholera toxin B subunit demonstrated that neurons of vagal motor nuclei that innervate the trachea and esophagus express AR and ERα. There was no difference in expression of sex steroid hormone receptors between trachea- and esophagus-innervating neurons. These results suggest that sex steroid hormones may act on vagal motor nuclei via their receptors, thereby regulating functions of the trachea and esophagus.
authors.affiliation: Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan; Department of Otolaryngology-Bronchoesophagology, Kyoto Second Red Cross Hospital, Kamanza-Marutamachi, Kyoto 602-8026, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Mukudai
authors.affiliation: Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine.
authors.forename: Ken
authors.initials: K
authors.lastname: Ichi Matsuda
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine , Kawaramachi-Hirokoji, Kyoto 602-8566, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Bando
authors.affiliation: Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine; Ushimado Marine Institute, Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi, Okayama 701-4303, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Takanami
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine , Kawaramachi-Hirokoji, Kyoto 602-8566, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishio
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine , Kawaramachi-Hirokoji, Kyoto 602-8566, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Sugiyama
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan; Faculty of Health and Medical Sciences, Kyoto Gakuen University, 18, Gotanda-cho, Yamanouchi, Kyoto 615-8577, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hisa
authors.affiliation: Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine; School of Health Sciences, Bukkyo University, 7, Higashitoganoo-cho, Nishinokyo, Kyoto 604-8418, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kawata
keywords: dorsal motor nucleus of the vagus; esophagus; nucleus ambiguus; sex hormone receptors; trachea