title: [Recruitment of osteogenic cells to bone formation sites during development and fracture repair - German Version].
abstract: Recruitment of osteoblast lineage cells to their bone-forming locations is essential for skeletal development and fracture healing. In developing bones, osteoprogenitor cells invade the cartilage mold to establish the primary ossification center. Similarly, osteogenic cells infiltrate and populate the callus tissue that is formed following an injury. Proper bone development and successful fracture repair must, therefore, rely on controlled temporal and spatial navigation cues guiding the cells to the sites where new bone formation is needed. Some cellular mechanisms and molecular pathways involved have been elucidated.
authors.affiliation: Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Gasthuisberg O&N 1, Herestraat 49, Box 813, 3000, Leuven, Belgien.
authors.forename: A-M
authors.initials: AM
authors.lastname: Böhm
authors.affiliation: Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Gasthuisberg O&N 1, Herestraat 49, Box 813, 3000, Leuven, Belgien.
authors.forename: N
authors.initials: N
authors.lastname: Dirckx
authors.affiliation: Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Gasthuisberg O&N 1, Herestraat 49, Box 813, 3000, Leuven, Belgien. christa.maes@med.kuleuven.be.
authors.forename: C
authors.initials: C
authors.lastname: Maes
mesh_terms: D000818:Animals; D001846:Bone Development / Q000502:physiology*; D001861:Bone Regeneration / Q000502:physiology; D002358:Cartilage, Articular / Q000502:physiology*; D002454:Cell Differentiation; D002465:Cell Movement / Q000502:physiology; D017102:Fracture Healing / Q000502:physiology*; D005858:Germany; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D023822:Tissue Engineering; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D051793:Hypoxia-Inducible Factor 1; D042461:Vascular Endothelial Growth Factor A
keywords: Angiogenesis; Cell migration; Fracture healing; Mesenchymal progenitor cell; Osteoblast; Osteoprogenitor recruitment