title: The role of endothelial cells on islet function and revascularization after islet transplantation.
abstract: Islet transplantation has become a widely accepted therapeutic option for selected patients with type 1 diabetes mellitus. However, in order to achieve insulin independence a great number of islets are often pooled from 2 to 4 pancreata donors. Mostly, it is due to the massive loss of islets immediately after transplant. The endothelium plays a key role in the function of native islets and during the revascularization process after islet transplantation. However, if a delayed revascularization occurs, even the remaining islets will also undergo to cell death and late graft dysfunction. Therefore, it is essential to understand how the signals are released from endothelial cells, which might regulate both differentiation of pancreatic progenitors and thereby maintenance of the graft function. New strategies to facilitate islet engraftment and a prompt revascularization could be designed to intervene and might lead to improve future results of islet transplantation.
authors.affiliation: a Department of Physiology, Laboratory of Immunology, Tissue Engineering and Transplant , University Center for Health Sciences, University of Guadalajara , Mexico ;
authors.forename: Alicia
authors.initials: A
authors.lastname: Del Toro-Arreola
authors.affiliation: b Institute of Sciences for Human Reproduction "Vida" Guadalajara , Mexico.
authors.forename: Ana Karina
authors.initials: AK
authors.lastname: Robles-Murillo
authors.affiliation: a Department of Physiology, Laboratory of Immunology, Tissue Engineering and Transplant , University Center for Health Sciences, University of Guadalajara , Mexico ;
authors.forename: Adrian
authors.initials: A
authors.lastname: Daneri-Navarro
authors.affiliation: a Department of Physiology, Laboratory of Immunology, Tissue Engineering and Transplant , University Center for Health Sciences, University of Guadalajara , Mexico ;
authors.forename: Jorge David
authors.initials: JD
authors.lastname: Rivas-Carrillo
mesh_terms: D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007515:Islets of Langerhans / Q000033:anatomy & histology / Q000098:blood supply* / Q000166:cytology / Q000502:physiology*; D016381:Islets of Langerhans Transplantation; D018919:Neovascularization, Physiologic / Q000502:physiology*
keywords: islet transplantation; islets function; revascularization