title: An ultrasensitive and selective method for the determination of Ceftriaxone using cysteine capped cadmium sulfide fluorescence quenched quantum dots as fluorescence probes.
abstract: In this paper, l-cysteine (Cys) coated CdS quantum dots (QDs) have been prepared, which have excellent water-solubility and are highly stable in aqueous solution. These QDs is proposed as sensitizers for the determination of Ceftriaxone. The quantum dot nanoparticles were structurally and optically characterized by Ultra Violet-Visible absorption Spectroscopy (UV-vis absorption spectroscopy), Fourier transform infrared spectroscopy (FT-IR spectra) and photoluminescence (PL) emission spectroscopy. High resolution transmission electron microscopy (HRTEM) confirms that the Cys-CdS QDs have a spherical structure with good crystallinity. Therefore, a new simple and selective PL analysis system was developed for the determination of Ceftriaxone (CFX). Under the optimum conditions, The response of l-Cys capped CdS QDs as the probe was linearly proportional to the concentration of Ceftriaxone ions in the range of 1.6×10(-9)-1.1×10(-3)M with a correlation coefficient (R2) of 0.9902. The limit of detection of this system was found to be 1.3nM. This method is simple, sensitive and low cost.
authors.affiliation: Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran. Electronic address: Samadi76@yahoo.com.
authors.forename: Naser
authors.initials: N
authors.lastname: Samadi
authors.affiliation: Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran. Electronic address: saeedeh.narimani@gmail.com.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Narimani
mesh_terms: D015374:Biosensing Techniques; D019187:Cadmium Compounds / Q000737:chemistry*; D002443:Ceftriaxone / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D003545:Cysteine / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D013050:Spectrometry, Fluorescence / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D005456:Fluorescent Dyes; D007477:Ions; D013440:Sulfides; C034939:cadmium sulfide; D002443:Ceftriaxone; D003545:Cysteine
keywords: CdS quantum dots; Ceftriaxone; Probe; l-cysteine