title: Improving the quantitative accuracy of cerebral oxygen saturation in monitoring the injured brain using atlas based Near Infrared Spectroscopy models.
abstract: The application of Near Infrared Spectroscopy (NIRS) for the monitoring of the cerebral oxygen saturation within the brain is well established, albeit using temporal data that can only measure relative changes of oxygenation state of the brain from a baseline. The focus of this investigation is to demonstrate that hybridisation of existing near infrared probe designs and reconstruction techniques can pave the way to produce a system and methods that can be used to monitor the absolute oxygen saturation in the injured brain. Using registered Atlas models in simulation, a novel method is outlined by which the quantitative accuracy and practicality of NIRS for specific use in monitoring the injured brain, can be improved, with cerebral saturation being recovered to within 10.1 ± 1.8% of the expected values.
authors.affiliation: PSIBS Doctoral Training Centre, University of Birmingham, United Kingdom. mxc933@bham.ac.uk.
authors.forename: Michael
authors.initials: M
authors.lastname: Clancy
authors.affiliation: NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, United Kingdom.
authors.forename: Antonio
authors.initials: A
authors.lastname: Belli
authors.affiliation: NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Davies
authors.affiliation: School of Sport, Exercise and Rehabilitation Science, University of Birmingham, United Kingdom.
authors.forename: Samuel J E
authors.initials: SJ
authors.lastname: Lucas
authors.affiliation: NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, United Kingdom.
authors.forename: Zhangjie
authors.initials: Z
authors.lastname: Su
authors.affiliation: School of Computer Science, University of Birmingham, United Kingdom.
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
mesh_terms: D001930:Brain Injuries / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen
keywords: brain injury; diffuse optical tomography; near infrared spectroscopy