title: Binary and ternary cocrystals of sulfa drug acetazolamide with pyridine carboxamides and cyclic amides.
abstract: A novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers. Binary adducts of acetazolamide (ACZ) with lactams (valerolactam and caprolactam, VLM, CPR), cyclic amides (2-pyridone, labeled as 2HP and its derivatives MeHP, OMeHP) and pyridine amides (nicotinamide and picolinamide, NAM, PAM) were obtained by manual grinding, and their single crystals by solution crystallization. The heterosynthons in the binary cocrystals of ACZ with these coformers suggested a ternary combination for ACZ with pyridone and nicotinamide. Novel supramolecular synthons of ACZ with lactams and pyridine carboxamides are reported together with binary and ternary cocrystals for a sulfonamide drug. This crystal engineering study resulted in the first ternary cocrystal of acetazolamide with amide coformers, ACZ-NAM-2HP (1:1:1).
authors.affiliation: School of Chemistry, University of Hyderabad , Prof. C. R. Rao Road, Central University PO, Hyderabad 500 046, India.
authors.forename: Geetha
authors.initials: G
authors.lastname: Bolla
authors.affiliation: School of Chemistry, University of Hyderabad , Prof. C. R. Rao Road, Central University PO, Hyderabad 500 046, India.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Nangia
keywords: co-crystals; crystal design; crystal engineering; hydrogen bonding; pharmaceutical solids