title: Association of EPHB1 rs11918092 and EFNB2 rs9520087 with psychopathological symptoms of schizophrenia in Chinese Zhuang and Han populations.
abstract: Two single-nucleotide polymorphisms (SNPs) (rs11918092 and rs9520087) were genotyped in Chinese Zhuang and Han populations. Symptoms of schizophrenic patients were assessed by the Positive and Negative Syndrome Scale. No association of any SNP with schizophrenic susceptibility was found. However, associations of rs9520087 with the total scale score (P = 0.014), positive scale score (P = 0.013), negative scale score (P = 0.032), and general psychopathology scale score (P = 0.031) were found in Zhuang patients. Additionally, rs11918092 was associated with positive scale score (P = 0.035) in Han patients. The two SNPs might influence symptoms of schizophrenia.
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Ling
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Guangxi Brain Hospital, Liuzhou, Guangxi, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Fan
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Guo
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Guifeng
authors.initials: G
authors.lastname: Huang
authors.affiliation: Guangxi Brain Hospital, Liuzhou, Guangxi, China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Xie
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. longjx12345@163.com.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Long
mesh_terms: D002681:China / Q000208:ethnology; D036388:Ephrin-B2 / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D036225:Receptor, EphB1 / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics / Q000503:physiopathology
chemical_list: C000601239:EFNB2 protein, human; D036388:Ephrin-B2; D036225:Receptor, EphB1
keywords: clinical symptoms; polymorphism; rs11918092; rs9520087; schizophrenia