title: Functional brain substrate of quality of life in patients with schizophrenia: A brain SPECT multidimensional analysis.
abstract: The aim of this study was to investigate the functional brain substrate of quality of life (QoL) in patients with schizophrenia. Participants comprised 130 right-handed patients with schizophrenia who underwent whole-brain single photon emission computed tomography (SPECT) with (99m)Tc-labeled ethylcysteinate dimer ((99m)Tc-ECD) for exploring correlations of regional cerebral blood flow (rCBF) with the eight dimensions score of the Schizophrenia Quality of Life questionnaire (S-QoL 18). A significant positive correlation was found between the global index of the S-QoL 18 and rCBF in the right superior temporal sulcus and between psychological well-being dimension and rCBF in Brodmann area (BA)6, BA8, BA9, and BA10 and between self-esteem dimension and rCBF in striatum and between family relationship dimension and rCBF in BA1, BA2, BA3, BA4, BA8, BA22, BA40, BA42 and BA44 and between relationship with friends dimension and rCBF in BA44 and between physical well-being dimension and rCBF in parahippocampal gyrus, and finally between autonomy dimension and rCBF in cuneus and precuneus. A significant negative correlation was found between resilience dimension and rCBF in precuneus and between sentimental life dimension and rCBF in BA10. Our findings provide neural correlates of QoL. Brain regions involved in cognitions, emotional information processing and social cognition underlie the different QoL dimensions.
authors.affiliation: Aix-Marseille University, EA 3279, 13005 Marseille, France; Department of Psychiatry, Conception University Hospital, 13005 Marseille, France; EA 3279-Public Health, Chronic Diseases and Quality of Life, School of Medicine, Timone University, 13005 Marseille, France. Electronic address: catherine.faget@ap-hm.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Faget-Agius
authors.affiliation: Aix-Marseille University, EA 3279, 13005 Marseille, France; Department of Public Health, La Timone University Hospital, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France; EA 3279-Public Health, Chronic Diseases and Quality of Life, School of Medicine, Timone University, 13005 Marseille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.affiliation: Aix-Marseille University, EA 3279, 13005 Marseille, France; Department of Psychiatry, Conception University Hospital, 13005 Marseille, France; EA 3279-Public Health, Chronic Diseases and Quality of Life, School of Medicine, Timone University, 13005 Marseille, France.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.affiliation: Aix-Marseille University, EA 3279, 13005 Marseille, France; Department of Public Health, La Timone University Hospital, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France; EA 3279-Public Health, Chronic Diseases and Quality of Life, School of Medicine, Timone University, 13005 Marseille, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Auquier
authors.affiliation: Aix-Marseille University, EA 3279, 13005 Marseille, France; Department of Psychiatry, Conception University Hospital, 13005 Marseille, France; EA 3279-Public Health, Chronic Diseases and Quality of Life, School of Medicine, Timone University, 13005 Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lançon
authors.affiliation: Service Central de Biophysique et Médecine Nucléaire, La Timone University Hospital, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France; Centre Européen de Recherche en Imagerie Médicale (CERIMED), Aix-Marseille University, Marseille 13005, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D011788:Quality of Life; D012189:Retrospective Studies; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
keywords: Decision making; Emotional processing; Social cognition