title: New norterpenoids and a sphingolipid from Carissa opaca.
abstract: Chemical investigations on the aerial parts of Carissa opaca resulted in the isolation and characterization of two new nor-triterpenoids (compounds 1 and 2) and a new sphingolipid (compound 3) together with six known compounds. The structures of all the isolates were established using spectral data. All the isolated compounds showed DPPH radical scavenging and enzyme inhibitory activities against enzymes acetylcholinesterase, butyrylcholinesterase, and lipoxygenase.
authors.affiliation: a Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.forename: Shehla
authors.initials: S
authors.lastname: Parveen
authors.affiliation: a Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
authors.affiliation: a Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.affiliation: a Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.|b Department of Biochemistry and Biotechnology, Baghdad-ul-Jadeed Campus , The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.affiliation: b Department of Biochemistry and Biotechnology, Baghdad-ul-Jadeed Campus , The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.lastname: Qurat-Ul-Ain
authors.affiliation: c Department of Botany , University of Gujrat , Gujrat 50700 , Pakistan.
authors.forename: Muhammad Farrukh
authors.initials: MF
authors.lastname: Nisar
authors.affiliation: a Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D029062:Apocynaceae / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002091:Butyrylcholinesterase / Q000187:drug effects; D006028:Glycosphingolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008084:Lipoxygenase / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D010851:Picrates / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D013107:Sphingolipids; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; D006028:Glycosphingolipids; D010851:Picrates; D013107:Sphingolipids; D014315:Triterpenes; C000609935:carisnin; C000609933:carisursane A; C000609934:carisursane B; C004931:1,1-diphenyl-2-picrylhydrazyl; D008084:Lipoxygenase; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
keywords: Carissa opaca; acetylcholinesterase inhibition; butyrylcholinesterase inhibition; lipoxygenase inhibition; nor-triterpenoid; sphingolipid