title: Selenium Deficiency Influences the Expression of Selenoproteins and Inflammatory Cytokines in Chicken Aorta Vessels.
abstract: Selenium deficiency is known to cause cardiovascular diseases. However, the role of Se deficiency in causing oxidative damage and inflammation injury to the aorta vessels of chickens is not well known. In the present study, 180 1-day-old chickens were randomly divided into two groups, a low-Se group (L group) and a control-Se group (C group). The messenger RNA (mRNA) levels of 25 selenoproteins, the mRNA and protein expression levels of inflammatory cytokines (including NF-κB, TNF-α, COX-2, and PTGES), and the antioxidant levels in chicken aorta vessels were examined. The results showed that the mRNA levels of 25 selenoproteins and the activity of Gpx were decreased, while the mRNA and protein expression levels of inflammatory cytokines and the MDA content were increased by Se deficiency in chicken aorta vessels. The data from the present study indicated that Se deficiency decreases the expression of selenoproteins, reduces antioxidant function, and increases the expression of inflammatory factors in chicken aorta vessels.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Du
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Yao
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Yao
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Food Science and Nutrition Engineering, China Agricultural University, Beijing, People's Republic of China. XL20@cornell.edu.|Department of Animal Science, Cornell University, Ithaca, NY, USA. XL20@cornell.edu.
authors.forename: Xingen
authors.initials: X
authors.lastname: Lei
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China. shiwenxu@neau.edu.cn.
authors.forename: Shiwen
authors.initials: S
authors.lastname: Xu
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism* / Q000473:pathology; D030161:Avian Proteins / Q000096:biosynthesis*; D002645:Chickens; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D005786:Gene Expression Regulation; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D012643:Selenium / Q000172:deficiency*; D051140:Selenoproteins / Q000096:biosynthesis*
chemical_list: D030161:Avian Proteins; D016207:Cytokines; D018836:Inflammation Mediators; D051140:Selenoproteins; D012643:Selenium
keywords: Aorta vessel; Chicken; Inflammatory cytokine; Selenium deficiency; Selenoprotein