title: Dissecting Molecular Mechanisms in Bile Acid Diarrhea.
abstract: It was previously demonstrated that patients with bile acid (BA) diarrhea have low fasting serum levels of the ileal hormone--fibroblast growth factor-19 (FGF-19). In this paper, the authors demonstrate a positive correlation between ileal transcripts of FGF-19 and (75)SeHCAT retention, providing further evidence of FGF-19 deficiency as an explanation for BA diarrhea. Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with (75)SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.
authors.affiliation: Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Camilleri
mesh_terms: D001647:Bile Acids and Salts / Q000096:biosynthesis*; D003967:Diarrhea; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007082:Ileum; D008297:Male; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000235:genetics*
chemical_list: D001647:Bile Acids and Salts; D005346:Fibroblast Growth Factors; D051499:Receptor, Fibroblast Growth Factor, Type 4