title: Are increased oxidative stress and asymmetric dimethylarginine levels associated with masked hypertension?
abstract: OBJECTIVE
  In this study, our aim was to determine total oxidative stress and asymmetric dimethylarginine (ADMA) levels in patients with masked hypertension (MHT) and to examine their association with blood pressure.
  
  
  METHODS
  Fifty patients diagnosed with MHT and 48 healthy volunteers without any known chronic diseases have been included in this study.
  
  
  RESULTS
  When compared to the control group, patients with MHT had higher levels of mean ADMA (p < 0.001), total oxidant status (TOS) (p < 0.001), and oxidative stress index (OSI) (p < 0.001), and a lower mean total antioxidant status (TAS) (p < 0.001) level. While a positive correlation was determined between the systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels with ADMA, TOS, and OSI levels, a negative correlation was determined with the TAS level. During the stepwise multivariable logistic regression analysis, age (OR = 1.221; p = 0.003), body mass index (OR = 1.512; p = 0.005), low density lipoprotein (OR = 0.925; p = 0.016), ADMA (OR = 1.200; p = 0.002), and OSI (OR = 3.750; p = 0.002) levels were determined to be the predictors of MHT. During the linear regression analysis, it was determined that the independent risk factors of SBP and DBP are ADMA and OSI, and the independent risk factor of TOS, OSI, and ADMA is SBP. Our study found out that oxidative stress and ADMA levels of patients with MHT are higher than those of the control group. ADMA and OSI were determined to be predictors of MHT.
  
  
  CONCLUSIONS
  Based on these results, it could be said that oxidative stress, and therefore the ADMA level, could have an effect on the etiopathogenesis of MHT.
authors.affiliation: a Internal Medicine Department , Ankara Numune Training and Research Hospital , Ankara , Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Inan
authors.affiliation: a Internal Medicine Department , Ankara Numune Training and Research Hospital , Ankara , Turkey.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ates
authors.affiliation: b Nephrology Department , Ankara Numune Training and Research Hospital , Ankara , Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozkayar
authors.affiliation: c Cardiology Department , Ankara Numune Training and Research Hospital , Ankara , Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.affiliation: d Biochemistry Department , Ankara Numune Training and Research Hospital , Ankara , Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topcuoglu
authors.affiliation: b Nephrology Department , Ankara Numune Training and Research Hospital , Ankara , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Dede
authors.affiliation: a Internal Medicine Department , Ankara Numune Training and Research Hospital , Ankara , Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Sennaroglu
mesh_terms: D000328:Adult; D000367:Age Factors; D000975:Antioxidants / Q000378:metabolism; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D059468:Masked Hypertension / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D016877:Oxidants; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: Endothelial dysfunction; isolated ambulatory hypertension; nitric oxide synthase; total antioxidant status; total oxidant status