title: Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors.
abstract: Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d, 5e, 5f, 5g, 5h, and 5k, have exhibited potent inhibitory activity on PDE.
authors.affiliation: Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
authors.forename: Mahadev N
authors.initials: MN
authors.lastname: Kumbar
authors.affiliation: Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
authors.forename: Ravindra R
authors.initials: RR
authors.lastname: Kamble
authors.affiliation: Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
authors.forename: Atulkumar A
authors.initials: AA
authors.lastname: Kamble
authors.affiliation: Centre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Sujith Raj
authors.initials: SR
authors.lastname: Salian
authors.affiliation: Centre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Kumari
authors.affiliation: Centre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Ramya
authors.initials: R
authors.lastname: Nair
authors.affiliation: Centre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Guruprasad
authors.initials: G
authors.lastname: Kalthur
authors.affiliation: Centre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Satish Kumar
authors.initials: SK
authors.lastname: Adiga
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Konaje, Karnataka 574199, India.
authors.forename: D Jagadeesh
authors.initials: DJ
authors.lastname: Prasad