title: Clinicopathological analysis of salivary gland tissue from patients with IgG4-related disease.
abstract: Conclusion The diagnosis of immunoglobulin G4-related disease (IgG4-RD) should be based on the morphology of tissue biopsy, and this study recommends a submandibular gland (SMG) biopsy for accurate diagnosis and to exclude malignant disease. Objective To clarify which type of biopsy specimen (SMG or labial salivary gland [LSG]) should be taken from patients with IgG4-RD. Methods This study included 33 patients with IgG4-RD (21 women; 12 men) who were subjected to both SMG and LSG biopsies at Sapporo Medical University between 2011-2015. Tissues obtained from the SMG and LSG specimens were evaluated. Results All SMG specimens satisfied the diagnostic criteria for IgG4-RD, whereas 19 (57.6%) LSG specimens satisfied the diagnostic criteria for IgG4-RD. Histological evaluation showed fibrosis in all the SMG specimens and in eight LSG specimens (24.2%). Obliterative phlebitis was seen in nine SMG specimens (27.3%), but it was absent in all the LSG specimens.
authors.affiliation: a Department of Otolaryngology , Sapporo Medical University School of Medicine , Sapporo , Japan ;
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takano
authors.affiliation: a Department of Otolaryngology , Sapporo Medical University School of Medicine , Sapporo , Japan ;
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Nomura
authors.affiliation: a Department of Otolaryngology , Sapporo Medical University School of Medicine , Sapporo , Japan ;
authors.forename: Ayumi
authors.initials: A
authors.lastname: Abe
authors.affiliation: a Department of Otolaryngology , Sapporo Medical University School of Medicine , Sapporo , Japan ;|b Department of Human Immunology , Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine , Sapporo , Japan ;
authors.forename: Ryuta
authors.initials: R
authors.lastname: Kamekura
authors.affiliation: c Division of Rheumatology and Clinical Immunology , Sapporo Medical University School of Medicine , Sapporo , Japan ;
authors.forename: Motohisa
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: b Department of Human Immunology , Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine , Sapporo , Japan ;|d Department of Surgical Pathology , Sapporo Medical University School of Medicine , Sapporo , Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Ichimiya
authors.affiliation: c Division of Rheumatology and Clinical Immunology , Sapporo Medical University School of Medicine , Sapporo , Japan ;
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: a Department of Otolaryngology , Sapporo Medical University School of Medicine , Sapporo , Japan ;
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Himi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D001706:Biopsy; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012466:Salivary Gland Diseases / Q000276:immunology / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000276:immunology / Q000473:pathology*; D013363:Submandibular Gland / Q000276:immunology / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G
keywords: Biopsy; IgG4-related disease; diagnostic criteria; fibrosis; salivary glands