title: Neoantigen: A Long March toward Cancer Immunotherapy.
abstract: Somatic mutations in cancer give rise to neoantigens. Technology revolutions in cancer genomics and immunology have made it possible to rapidly identify neoantigens for cancer vaccines. Leisegang and colleagues report that it is practical to rapidly identify neoantigens for adoptive T-cell therapy in a mouse tumor model. Clin Cancer Res; 22(11); 2602-4. ©2016 AACRSee related article by Leisegang et al., p. 2734.
authors.affiliation: Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, and Department of Pediatrics, George Washington University School of Medicine, Washington, DC.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm; D015316:Genetic Therapy; D007167:Immunotherapy; D051379:Mice; D009369:Neoplasms; D017354:Point Mutation; D011948:Receptors, Antigen, T-Cell
chemical_list: D000951:Antigens, Neoplasm; D011948:Receptors, Antigen, T-Cell