title: Effects of Amygdaline from Apricot Kernel on Transplanted Tumors in Mice.
abstract: The effects of amygdaline from apricot kernel added to fodder on the growth of transplanted LYO-1 and Ehrlich carcinoma were studied in mice. Apricot kernels inhibited the growth of both tumors. Apricot kernels, raw and after thermal processing, given 2 days before transplantation produced a pronounced antitumor effect. Heat-processed apricot kernels given in 3 days after transplantation modified the tumor growth and prolonged animal lifespan. Thermal treatment did not considerably reduce the antitumor effect of apricot kernels. It was hypothesized that the antitumor effect of amygdaline on Ehrlich carcinoma and LYO-1 lymphosarcoma was associated with the presence of bacterial genome in the tumor.
authors.affiliation: Russian Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia. yamshanov@mail.ru.
authors.forename: V A
authors.initials: VA
authors.lastname: Yamshanov
authors.affiliation: Russian Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Kovan'ko
authors.affiliation: Russian Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Pustovalov
mesh_terms: D000678:Amygdalin / Q000627:therapeutic use*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D051379:Mice; D009368:Neoplasm Transplantation; D028321:Plant Preparations / Q000627:therapeutic use; D000068219:Prunus armeniaca / Q000378:metabolism*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D028321:Plant Preparations; D000678:Amygdalin
keywords: Ehrlich carcinoma; LYO-1 lymphosarcoma; amygdaline; apricot kernels