title: SPECIFIC BLOOD ABSORPTION PARAMETERS FOR 239PUO2 AND 238PUO2 NANOPARTICLES AND IMPACTS ON BIOASSAY INTERPRETATION.
abstract: Specific absorption parameters for 239PuO2 and 238PuO2 have been determined based on available biokinetic data from studies in rodents, and the impacts of these parameters on bioassay interpretation and dosimetry after inhalation of nanoPuO2 materials have been evaluated. Calculations of activities after an acute intake of nanoparticles of 239PuO2 and 238PuO2 are compared with the corresponding calculations using standard default absorption parameters using the International Commission on Radiological Protection (ICRP) 66 respiratory tract model. Committed effective doses are also evaluated and compared. In this case, it was found that interpretation of bioassay measurements with the assumption that the biokinetic behaviour of PuO2 nanoparticles is the same as that of micrometre-sized particles can result in an overprediction of the committed effective dose by two orders of magnitude. Although in this case the use of the default assumptions (5 µm AMAD, Type S) for assessing dose following inhalation exposure to airborne PuO2 nanoparticles appears to be conservative, the evaluation of situations involving PuO2 nanoparticles that may have different particle size and solubility properties should prudently follow the ICRP recommendation to obtain and use additional, material-specific information whenever possible.
authors.affiliation: Los Alamos National Laboratory, PO Box 1663, MS T086, Los Alamos, NM 87545, USA.
authors.forename: Leigh J
authors.initials: LJ
authors.lastname: Cash
authors.affiliation: Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road Morgantown, WV 26505, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Hoover
authors.affiliation: Lovelace Respiratory Research Institute, Albuquerque, NM, USA.|Ray Guilmette and Associates LLC, 13 Sunrise Shores Drive, Perry, ME 04667, USA.
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Guilmette
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room E6630, Baltimore, MD 21205, USA.
authors.forename: Patrick N
authors.initials: PN
authors.lastname: Breysse
authors.affiliation: Los Alamos National Laboratory, PO Box 1663, MS T086, Los Alamos, NM 87545, USA.
authors.forename: Luiz
authors.initials: L
authors.lastname: Bertelli
mesh_terms: D001681:Biological Assay; D006801:Humans; D008954:Models, Biological; D053758:Nanoparticles; D011005:Plutonium; D011829:Radiation Dosage
chemical_list: D011005:Plutonium