title: Sclerostin levels in uremic patients: a link between bone and vascular disease.
abstract: Sclerostin is a marker of low-turnover bone disease in end stage renal disease patients. The aim of this study was to evaluate serum sclerostin in uremic patients, analyzing its behavior during a single hemodialysis session. Twenty-one adult patients on intermittent hemodialysis treatment were enrolled. Acetate Free Bio-filtration (AFB) was the technique employed. Uremic patients were characterized by higher levels of serum sclerostin when compared with values observed in healthy subjects. Sclerostin assessed in pre-dialysis samples was 1.4 ± 1.02 ng/mL, whereas, in post dialysis samples, a reduction of sclerostin values was observed (0.8 ± 0.6 ng/mL; p: 0.008). Sclerostin correlated with parameters of dialysis adequacy, such as creatinine levels and Kt/V values, and it was significantly associated with atherosclerotic disease. Receiver operating characteristics analysis revealed a good diagnostic profile in identifying atherosclerotic disease. Sclerostin, a full dialyzable substance during AFB dialysis, is closely associated with atherosclerotic disease. Its reduction obtained through AFB could represent a defensive mechanism, improving vascular disease and renal osteodystrophy.
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Annamaria
authors.initials: A
authors.lastname: Bruzzese
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Antonio
authors.initials: A
authors.lastname: Lacquaniti
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Valeria
authors.initials: V
authors.lastname: Cernaro
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Carlo Alberto
authors.initials: CA
authors.lastname: Ricciardi
authors.affiliation: b Department of Pathology , University of Messina , Messina , Italy ;
authors.forename: Saverio
authors.initials: S
authors.lastname: Loddo
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Adolfo
authors.initials: A
authors.lastname: Romeo
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Gaetano
authors.initials: G
authors.lastname: Montalto
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Costantino
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Francesco
authors.initials: F
authors.lastname: Torre
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Pettinato
authors.affiliation: c Department of Biomedical Sciences and Morphological and Functional Imaging , University of Messina , Messina , Italy.
authors.forename: Ignazio
authors.initials: I
authors.lastname: Salamone
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Carmela
authors.initials: C
authors.lastname: Aloisi
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Domenico
authors.initials: D
authors.lastname: Santoro
authors.affiliation: a Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy ;
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D016723:Bone Remodeling; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis / Q000378:metabolism* / Q000517:prevention & control; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D015203:Reproducibility of Results; D013223:Statistics as Topic; D014511:Uremia / Q000150:complications / Q000209:etiology / Q000378:metabolism / Q000628:therapy
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human
keywords: Acetate Free Bio-filtration; Chronic kidney disease-mineral and bone disorder; atherosclerotic disease; sclerostin; vascular calcification