title: Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.
abstract: Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Landy
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Emma
authors.initials: E
authors.lastname: Ronde
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Nick
authors.initials: N
authors.lastname: English
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Sue K
authors.initials: SK
authors.lastname: Clark
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Ailsa L
authors.initials: AL
authors.lastname: Hart
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Stella C
authors.initials: SC
authors.lastname: Knight
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Ciclitira
authors.affiliation: Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.
authors.forename: Hafid Omar
authors.initials: HO
authors.lastname: Al-Hassi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D057167:Claudins / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D010539:Permeability; D019449:Pouchitis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D019108:Tight Junctions / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D057167:Claudins; D018836:Inflammation Mediators
keywords: Claudin; Crohn’s disease; Pouchitis; Tight junction; Ulcerative colitis