title: Transient Ocular Wavefront Data in Type 1 Diabetes Mellitus.
abstract: We report transient ocular wavefront and blood glucose data for one patient with acute type 1 diabetes mellitus after the treatment with insulin has been initiated.
  
  
  
  The wavefront data for both eyes of a 34-year-old male patient were examined by a Hartmann-Shack wavefront sensor. Refraction data and higher-order aberrations were recorded during 130 days for eyes in natural conditions, without cycloplegia. At the beginning, we sampled data every 3 to 4 days and enlarged the intervals, when values settled. In total, we report 20 measurements and 1 baseline entry. Blood glucose levels were recorded at least six times a day during the complete period. For the equivalent sphere, we recorded a bilateral hyperopic shift of 5 D from -2.75 DS to +2.25 DS, followed by a reverse myopic shift of the same amount. The equivalent sphere peaked about 15 to 18 days after the treatment with insulin had begun. Cylinder values kept remarkably stable. Higher-order aberrations are dominated by the spherical aberration. The Zernike coefficient c12 for both eyes changed substantially from OD 0.036 μm and OS 0.062 μm to OD 0.24 μm and OS 0.22 μm (5 mm pupil diameter) following the time pattern of the equivalent sphere. About 60 days after they had reached their peak, all refraction values and higher-order aberrations stabilized at their baseline levels. The baseline was defined by records taken 4 years before the treatment with insulin was commenced.
  
  
  
  Wavefront aberrometry gives quantitative insights in the transient alteration and recovering of the eye's optics whilst the therapy of acute type 1 diabetes mellitus is being initiated. The data of this case support the assumption that variations in the crystalline lens, most probably the modification of its refractive gradient index, as a cause for the transient behavior. An explanation is still missing.
authors.affiliation: *PhD †Dipl.-Ing. (FH), MSc Darmstadt University of Applied Sciences, Optical Technologies and Image Processing (RB, MK), Darmstadt, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Blendowske
authors.forename: Max
authors.initials: M
authors.lastname: Kalb
mesh_terms: D057128:Aberrometry; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D057108:Corneal Wavefront Aberration / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000628:therapy; D006801:Humans; D006956:Hyperopia / Q000209:etiology* / Q000503:physiopathology; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009216:Myopia / Q000209:etiology* / Q000503:physiopathology; D012029:Refraction, Ocular
chemical_list: D001786:Blood Glucose; D007328:Insulin