title: Diagnostic performance of a semiconductor gamma-camera system as studied by multicenter registry.
abstract: Despite the introduction of the novel cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) in Japan; its diagnostic value in clinical practice remains largely unknown.
  
  
  
  The Semiconductor SPECT Study group is a multicenter Japanese registry which registered 1000 patients to evaluate the diagnostic utility of the CZT camera system (Discovery NM530c; GE Healthcare, Haifa, Israel). The patients underwent stress myocardial SPECT and coronary angiography within a 3-month interval. A significant stenosis was defined as ≥75% diameter narrowing based on the American Heart Association classification.
  
  
  
  Technetium (99mTc) radiotracer (555-1110MBq) was used in 71% and thallium-201 (201Tl) (74-148MBq) in 29%. The scan times with99mTc-radiotracer were 5-10min for stress and 3-10min for rest, whereas those with201Tl were 5-9min for stress and 8-10min for rest. To detect individual coronary stenosis, the respective sensitivities, specificities, and accuracies were 74%, 85%, and 81% for left anterior descending coronary artery (LAD) stenosis, 76%, 89%, and 85% for left circumflex stenosis, and 72%, 86%, and 82% for right coronary artery stenosis. However, 66% sensitivity and 91% specificity for LAD stenosis were observed with99mTc-radiotracer, whereas 88% sensitivity and 63% specificity were found with201Tl.
  
  
  
  The novel CZT SPECT system facilitated a short scan time with reduced radiotracer dose, yielding an acceptable diagnostic performance for angiographical coronary artery disease, although the low sensitivity for LAD detection with99mTc-radiotracer needs to be refined.
authors.affiliation: Department of Cardiology, Tokyo Medical University, Tokyo, Japan. Electronic address: chikamd@tokyo-med.ac.jp.
authors.forename: Taishiro
authors.initials: T
authors.lastname: Chikamori
authors.affiliation: Department of Cardiology, Fukuyama Cardiovascular Hospital, Hiroshima, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Goto
authors.affiliation: Department of Cardiology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hida
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Miyagawa
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Ishimura
authors.affiliation: Department of Radiology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Uchida
authors.affiliation: Department of Cardiology, Shin-Koga Hospital, Fukuoka, Japan.
authors.forename: Takaya
authors.initials: T
authors.lastname: Fukuyama
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
authors.affiliation: Department of Cardiology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002104:Cadmium; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000175:diagnosis*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012042:Registries; D012680:Sensitivity and Specificity; D013667:Technetium; D013691:Tellurium; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents / Q000008:administration & dosage; D015032:Zinc
chemical_list: C474490:CdZnTe; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D014665:Vasodilator Agents; D002104:Cadmium; D013667:Technetium; D015032:Zinc; D013691:Tellurium
keywords: Cadmium–zinc–telluride camera; Coronary angiography; Coronary artery disease; Diagnosis; Single-photon emission computed tomography