title: Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus.
abstract: Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs at lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), and creatinine (Cr) were also tested. Data analyses revealed that serum UA levels were positively associated with BMD at all sites (p < 0.05) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight (r = 0.322), body mass index (BMI) (r = 0.331), Ca (r = 0.179), and Cr (r = 0.239) (p < 0.001) and were also positively associated with the concentrations of PTH (r = 0.10, p < 0.05). When compared with those in the lowest tertile of UA levels, men with T2DM in the highest tertile had a lower prevalence of osteoporosis or osteopenia (adjusted odds ratio 0.54, 95% confidence interval [CI] 0.31-0.95). These data suggest that higher serum levels of UA are associated with higher BMDs and lower risks of osteoporosis in Chinese men with T2DM.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Dian-Dian
authors.initials: DD
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Pei-Lin
authors.initials: PL
authors.lastname: Jiao
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Jing-Jia
authors.initials: JJ
authors.lastname: Yu
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xuan
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Li-Hao
authors.initials: LH
authors.lastname: Sun
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Tao
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Zhao