title: Hypertensive pathologies and egg donation pregnancies: Results of a large comparative cohort study.
abstract: OBJECTIVE
  To determine whether egg donation (ED) pregnancies are at higher risk of pregnancy-induced hypertension (PIH) than those achieved by autologous assisted reproductive technology (ART; controls).
  
  
  METHODS
  Anonymous comparative observational matched cohort study.
  
  
  METHODS
  Assisted reproductive technology centers.
  
  
  METHODS
  Two hundred seventeen ED and 363 control singleton pregnancies matched at 7-8 weeks (pregnancy date, parity, cycle type [fresh/frozen] and women's age). According to French practice, all women were under 45.
  
  
  METHODS
  None.
  
  
  METHODS
  Percentage of PIH for ED versus controls.
  
  
  RESULTS
  The groups were comparable (mean age, 34.5). PIH was more frequent during ED pregnancies (17.8% vs. 5.3%), as was preeclampsia (11.2% vs. 2.8%) and eclampsia (1.8% vs. 0.0%). In multivariate analyses, PIH risk increased with ED (odds ratio [OR], 3.92; 95% confidence interval [CI], 1.93-7.97) and women's age (OR, 1.08; 95% CI, 1.00-1.16). No significant effect of previous pregnancies or cycle rank/type was observed.
  
  
  CONCLUSIONS
  This study had sufficient power to detect doubling of the PIH rate. It was demonstrated that the risk of PIH was tripled for ED versus controls. Even in young women, ED is a risk factor for PIH. An immunological explanation seems most likely, that is, the fetus is fully allogeneic to its mother. This risk must be acknowledged to inform couples and provide careful pregnancy monitoring.
authors.affiliation: Centre de Fertilité, Institut Mutualiste Montsouris, Paris, France. Electronic address: helene.letur@imm.fr.
authors.forename: Hélène
authors.initials: H
authors.lastname: Letur
authors.affiliation: Service de Médecine de la Reproduction, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Maëliss
authors.initials: M
authors.lastname: Peigné
authors.affiliation: Service de Gynécologie-Obstétrique, Centre Médico-Chirurgical et Obstétrical, Centre Hospitalier Universitaire, Schiltigheim, France.
authors.forename: Jeanine
authors.initials: J
authors.lastname: Ohl
authors.affiliation: Service de Médecine de la Reproduction, Assistance Publique des Hôpitaux de Paris, Hôpital Jean-Verdier, Bondy, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cédrin-Durnerin
authors.affiliation: Service de Gynécologie Obstétrique, Assistance Publique des Hôpitaux de Paris, Hôpital Tenon, Paris, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Mathieu-D'Argent
authors.affiliation: Médecine et Biologie de la Reproduction, Cytogénétique et Centre d'Etude et de Conservation des Oeufs et du Sperme de Picardie, Centre Hospitalier Universitaire d'Amiens Sud, Amiens, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Scheffler
authors.affiliation: Service de Gynécologie-Obstétrique, Centre Hospitalier Intercommunal des 4 Villes, Site Sèvres, Sèvres, France.
authors.forename: Veronika
authors.initials: V
authors.lastname: Grzegorczyk-Martin
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Service de Gynécologie-Obstétrique II et Médecine de la Reproduction, APHP, Cochin Port Royal, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: de Mouzon
mesh_terms: D000328:Adult; D000367:Age Factors; D001794:Blood Pressure; D016009:Chi-Square Distribution; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007247:Infertility, Female / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D018587:Oocyte Donation / Q000009:adverse effects*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Hypertensive pathologies; eclampsia; egg donation; preeclampsia; pregnancy induced hypertension