title: Association of Cell-adhesion Activities with Virulence in Shiga toxin-producing Escherichia coli O103：H2.
abstract: The characteristics of 11 strains of Stx1-producing and Stx2-non-producing STEC O103：H2 were analyzed to investigate the differences in virulence in a single serotype of Shiga toxin (Stx) -producing Escherichia coli (STEC). Differences in the cell-adhesion activity to Caco-2 cells were observed among the strains. The activity of the one strain, isolated from a patient with hemolytic uremic syndrome was 4-20-fold higher than those of the other strains. Although the strains with high cell-adhesion activity showed high expressions of eae, espB, espD, and tir in the locus of enterocyte effacement related with cell-adhesion, those were not specific for this strain. In addition, the Stx1 production level of the strain was not particularly high. It was indicated that the high adhesion activity might be a potential factor to associate serious symptom.
authors.affiliation: National Institute of Health Sciences.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Eriko
authors.initials: E
authors.lastname: Maeda
authors.forename: Shioko
authors.initials: S
authors.lastname: Saito
authors.forename: Ichiro
authors.initials: I
authors.lastname: Furukawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Maiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Jun
authors.initials: J
authors.lastname: Terajima
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hara-Kudo
mesh_terms: D000293:Adolescent; D000328:Adult; D001422:Bacterial Adhesion / Q000235:genetics; D018938:Caco-2 Cells; D002648:Child; D002675:Child, Preschool; D005798:Genes, Bacterial; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D040641:Quantitative Trait Loci; D054323:Shiga-Toxigenic Escherichia coli / Q000502:physiology*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics; D055815:Young Adult
chemical_list: D037521:Virulence Factors