title: Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome.
abstract: OBJECTIVE
  To explore the relationships between the soluble receptor for advanced glycation endproducts (sRAGE) and the outcome parameters following in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) and investigate the protective effect of sRAGE in PCOS development regarding inflammation.
  
  
  METHODS
  We conducted a prospective analysis of a subsample of 74 participants from the Reproductive Medical Center of the First Affiliated Hospital of Zhengzhou University. We quantified sRAGE, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α), interleukelin-6 (IL-6), and C-reactive protein (CPR) protein levels in the follicular fluid from 39 PCOS and 35 non-PCOS reproductive-age women. sRAGE and VEGF, TNF-α, IL-6, and CRP in follicular fluid aspirated without blood were measured by ELISA.
  
  
  RESULTS
  sRAGE concentrations in the follicular fluid were significantly lower in the PCOS group compared to those in the control group, while VEGF, TNF-α, IL-6, and CRP concentrations were significantly higher in the PCOS group than in the control group (P < 0.05). sRAGE was significantly, inversely correlated with the total dose of gonadotropin (Gn) in the PCOS group undergoing IVF treatment (r = -0.451, P = 0.004). After adjusting for age and Gn dose (in international units used per cycle), sRAGE protein levels in the follicular fluid were significantly, inversely related to VEGF (r = -0.378, P = 0.018), TNF-α (r = -0.450, P = 0.004), IL-6 (r = -0.455, P = 0.004), and CRP (r = -0.375, P = 0.019).
  
  
  CONCLUSIONS
  sRAGE in the follicular fluid might exert a protective effect against the inflammatory action of PCOS development.
authors.affiliation: Department of Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road, Erqi District, Zhengzhou, 450052, Henan Province, People's Republic of China.|Department of Reproductive Medical Center, Third Affiliated Hospital of Zhengzhou University, Kangfu Qian Road, Erqi District, Zhengzhou, 450052, Henan Province, People's Republic of China.
authors.forename: BiJun
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road, Erqi District, Zhengzhou, 450052, Henan Province, People's Republic of China.
authors.forename: MengMeng
authors.initials: M
authors.lastname: Hao
authors.affiliation: Department of Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road, Erqi District, Zhengzhou, 450052, Henan Province, People's Republic of China.
authors.forename: QingLing
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road, Erqi District, Zhengzhou, 450052, Henan Province, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road, Erqi District, Zhengzhou, 450052, Henan Province, People's Republic of China. 13613863710@163.com.
authors.forename: YiHong
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D015850:Interleukin-6 / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000473:pathology*; D011446:Prospective Studies; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D000067759:Receptor for Advanced Glycation End Products; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D002097:C-Reactive Protein
keywords: Human reproduction; Inflammation; PCOS; Therapy; sRAGE