title: Platelet function in diabetic and nondiabetic patients with chronic obstructive pulmonary disease: a case control study.
abstract: BACKGROUND
  The effect of association between chronic obstructive pulmonary disease (COPD) and diabetes (DM) on platelet function has not been studied before.
  
  
  OBJECTIVE
  To evaluate the effect of the association between COPD and DM on platelet function and C reactive protein (CRP).
  
  
  METHODS
  This case control study was carried out on 110 stable COPD patients who were classified into diabetic and nondiabetic groups. In addition, 40 apparently healthy, age and sex-matched individuals were included in this study as a control group. Chest X-ray, pulmonary function testing and arterial blood gases were done for COPD patients. CRP and complete blood count (CBC) were measured in both patient and control groups.
  
  
  RESULTS
  Mean platelet volume (MPV), platelet distribution width (PDW), platelet crit (PCT) and CRP were significantly higher in COPD patients either nondiabetic or diabetic compared to control group. Moreover, MPV and CRP markers were significantly higher in COPD diabetic patients compared to nondiabetic. There was no significant difference in various laboratory data among different stages of COPD either diabetic or nondiabetic (P > 0.05). In COPD patients, MPV was a significantly positively correlated with CRP and PDW (r = 0.346, P < 0.001; r = 0.510, P < 0.001, respectively) and negatively correlated with PLT count (r = -0.294, P = 0.002).
  
  
  CONCLUSIONS
  MPV, PDW, PCT and CRP were significantly higher in COPD patients either nondiabetic or diabetic. Platelet function may be modified by the systemic inflammation that associated with COPD. Platelet activation as a prothrombotic sequence of this disease may be used as novel therapeutic target.
authors.affiliation: Department of Chest, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.
authors.forename: Hoda Ahmed
authors.initials: HA
authors.lastname: Makhlouf
authors.affiliation: Department of Chest, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.
authors.forename: Samiaa Hamdy
authors.initials: SH
authors.lastname: Sadek
authors.affiliation: Department of Clinical Pathology, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.
authors.forename: Asmaa Abdel Hakim
authors.initials: AAH
authors.lastname: Nafady
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D010976:Platelet Count; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies; D012720:Severity of Illness Index
keywords: COPD; CRP; diabetes; platelet function