title: Evaluation of cochlear nerve diameter and cross-sectional area in ANSD patients by 3.0-Tesla MRI.
abstract: CONCLUSIONS
  The size of cochlear nerve (CN) is atrophic in adult auditory neuropathy spectrum disorder (ANSD) patients compared with non-ANSD sensorineural hearing loss (SNHL) patients and normal hearing subjects, and CN deficiency is one of the lesions for ANSD patients.
  
  
  OBJECTIVE
  To evaluate the dimensions of CN in adult ANSD patients on magnetic resonance imaging (MRI) and confirm the hypothesis that CN deficiency is one of the lesions for ANSD patients.
  
  
  METHODS
  Medical records and MRI of 24 adult ANSD patients reviewed retrospectively and 20 non-ANSD SNHL and 24 volunteers with normal hearing were recruited as control groups. The long diameter (LD), short diameter (SD), and cross-sectional area (CSA) of CN and facial nerve (FN) were measured.
  
  
  RESULTS
  Among the 24 ANSD patients, this study was able to reconstruct and measure the CN of 91.7% (22/24, total 43 ears) of patients and FN of 83.3% (20/24, total 38 ears) of patients. The mean values and standard deviations of LD, SD, and CSA of CN in ANSD patients were 0.65 ± 0.20 mm, 0.44 ± 0.15 mm, and 0.30 ± 0.19 mm(2), respectively. They were significantly smaller in ANSD patients than in control groups (p < 0.001).
authors.affiliation: a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Liyan
authors.initials: L
authors.lastname: Peng
authors.affiliation: b Department of Radiology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: c Department of Otorhinolaryngology , Jingshan People's Hospital , Hubei , PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Zhongyao
authors.initials: Z
authors.lastname: Mao
authors.affiliation: a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Chen
authors.affiliation: a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Liangqiang
authors.initials: L
authors.lastname: Zhou
authors.affiliation: a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Bo
authors.initials: B
authors.lastname: Liao
authors.affiliation: a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Aiguo
authors.initials: A
authors.lastname: Liu
authors.affiliation: a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
authors.forename: Xinglong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D003056:Cochlear Nerve / Q000000981:diagnostic imaging*; D005260:Female; D006313:Hearing Loss, Central / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult
keywords: ANSD; cochlear nerve; magnetic resonance imaging