title: Thimerosal-Preserved Hepatitis B Vaccine and Hyperkinetic Syndrome of Childhood.
abstract: (1) BACKGROUND: Hyperkinetic syndrome of childhood (HKSoC) is an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9) category in which the majority of the children are also diagnosed under the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR), where the umbrella term is "Attention-Deficit and Disruptive Behavior Disorders". The diagnostic criteria for HKSoC are developmentally inappropriate inattention, hyperactivity, and impulsivity. Some studies have implicated mercury (Hg) exposure as a risk factor. (2) METHODS: This hypothesis testing study; using the Vaccine Safety Datalink; assessed the toxicological effects of bolus exposure to organic-Hg from Thimerosal-containing vaccines (TCVs) by examining the relationship between Thimerosal-preserved hepatitis B vaccines (TM-HepB) given at varying levels and at specific intervals in the first six months after birth and the risk of a child being diagnosed with HKSoC. (3) RESULTS: Children diagnosed with HKSoC were significantly more likely to be exposed to increased organic-Hg from TM-HepB doses given within the first month (odds ratio = 1.45; 95% confidence interval (CI) = 1.30-1.62); within the first two months (odds ratio = 1.43; 95% CI = 1.28-1.59); and within the first six months (odds ratio = 4.51; 95% CI = 3.04-6.71) than controls. (4) CONCLUSION: The results indicate that increasing organic-Hg exposure from TCVs heightens the risk of a HKSoC diagnosis.
authors.affiliation: Institute of Chronic Illnesses, Inc., Silver Spring, MD 20905, USA. davidallengeier@comcast.net.|CoMeD, Inc., Silver Spring, MD 20905, USA. davidallengeier@comcast.net.
authors.forename: David A
authors.initials: DA
authors.lastname: Geier
authors.affiliation: Institute of Chronic Illnesses, Inc., Silver Spring, MD 20905, USA. jkern@dfwair.net.|Council for Nutritional and Environmental Medicine, Mo i Rana, Norway. jkern@dfwair.net.
authors.forename: Janet K
authors.initials: JK
authors.lastname: Kern
authors.affiliation: Department of Biology, Simpson University, Redding, CA 96003, USA. bhooker@simpsonu.edu.|Focus for Health, Watchung, NJ 07069, USA. bhooker@simpsonu.edu.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Hooker
authors.affiliation: CoMeD, Inc., Silver Spring, MD 20905, USA. syklone5@verizon.net.
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Sykes
authors.affiliation: Institute of Chronic Illnesses, Inc., Silver Spring, MD 20905, USA. mgeier@comcast.net.|CoMeD, Inc., Silver Spring, MD 20905, USA. mgeier@comcast.net.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Geier
keywords: ADHD; Hyperkinetic syndrome of childhood; Thimerosal; neurodevelopmental disorder