title: Enantioselective Intermolecular Enamide-Aldehyde Cross-Coupling Catalyzed by Chiral N-Heterocyclic Carbenes.
abstract: The unprecedented N-heterocyclic carbene (NHC)-catalyzed intermolecular cross-coupling of enamides and aldehydes is described. Upon exposure of enamides to aldehydes in the presence of a NHC catalyst, catalytic C-C bond formation occurs, providing highly enantioselective N-protected amines, bearing a quaternary carbon center, in good yields and with high enantioselectivities.
authors.affiliation: School of Pharmaceutical Sciences and §School of Medicine, Tsinghua University , Beijing 100084, China.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Pharmaceutical Sciences and §School of Medicine, Tsinghua University , Beijing 100084, China.
authors.forename: Changgui
authors.initials: C
authors.lastname: Zhao
authors.affiliation: School of Pharmaceutical Sciences and §School of Medicine, Tsinghua University , Beijing 100084, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang