title: Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness.
abstract: Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4-1.2) vs. 0.5 (0.4-0.8) mm, p < 0.001] and EATT (6.8 ± 2.7 vs. 4.8 ± 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44-72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53-17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI -0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients.
authors.affiliation: Department of Cardiology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Saim
authors.identifier: 0000-0001-8404-8252
authors.initials: S
authors.lastname: Sag
authors.affiliation: Department of Nephrology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Abdulmecit
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: Department of Cardiology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Sumeyye
authors.initials: S
authors.lastname: Gullulu
authors.affiliation: Department of Cardiology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Gungoren
authors.affiliation: Department of Cardiology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Ozdemir
authors.affiliation: Department of Cardiology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Cegilli
authors.affiliation: Department of Nephrology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Oruc
authors.affiliation: Department of Nephrology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Ersoy
authors.affiliation: Department of Nephrology, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gullulu
keywords: Autosomal dominant polycystic kidney disease; Carotid intima-media thickness; Early atherosclerosis; Epicardial adipose tissue thickness; Preserved renal function