title: Impact of Mood and Behavioral Disorders on Quality of Life in Parkinson's disease.
abstract: BACKGROUND
  Mood symptoms negatively affect quality of life of Parkinson's disease (PD); however little is known about the impact of behavioral disorders such as impulse control disorders, and non-motor fluctuations on quality of life.
  
  
  OBJECTIVE
  To assess the impact of mood and behavioral disorders on quality of life in PD.
  
  
  METHODS
  136 (84% male) PD were included (mean age: 61 ± 8y; mean duration of disease: 8.8 ± 5.4y). Mood symptoms, behavioral disorders and non-motor fluctuations were detected and quantified using the recently validated "Ardouin Scale of Behavior in Parkinson's Disease". Motor symptoms were assessed using UPDRS and quality of life with the "39-item Parkinson's Disease Questionnaire".
  
  
  RESULTS
  Both motor and non-motor factors significantly affected the quality of life of PD patients. Multivariate regression of the relationship between items of the quality of life questionnaire and the Ardouin Scale showed that alteration of patients' quality of life was strongly correlated with the presence of mood symptoms (such as depression, anxiety ...) and with non-motor fluctuations (especially in the OFF period). A significant correlation was also found between the number of symptoms and their severity, and the quality of life deterioration. Some behavioral disorders (compulsive buying / eating behavior) also negatively affected patient's quality of life to a lesser extent. Alternatively, excess in motivation and hobbyism behaviors had a positive impact on mobility and emotional well-being dimensions respectively of quality of life.
  
  
  CONCLUSIONS
  This study shows the main impact of mood symptoms and non-motor fluctuations on worsening quality of life in PD.
authors.affiliation: CHU Clermont-Ferrand, Department of Neurology, CHU Gabriel Montpied, Clermont-Ferrand, France.|Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rieu
authors.affiliation: Department Neurology, CIC INSERM-0802, CHU de Poitiers 86021 Poitiers cedex; INSERM U 1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, France.
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Houeto
authors.affiliation: CHU Clermont-Ferrand, DRCI, Biostatistics Unit, Clermont-Ferrand, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pereira
authors.affiliation: Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.|CHU Clermont-Ferrand, Department of Psychiatry B, CHU Gabriel Montpied, Clermont-Ferrand, France.
authors.forename: Ingrid
authors.initials: I
authors.lastname: De Chazeron
authors.affiliation: Movement Disorder Unit, Department of Psychiatry and Neurology, CHU de Grenoble, Joseph Fourier University and INSERM, Unité 836, Grenoble Institut des Neurosciences, 38043 Grenoble, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Bichon
authors.affiliation: CHU Clermont-Ferrand, Department of Psychiatry B, CHU Gabriel Montpied, Clermont-Ferrand, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chéreau
authors.affiliation: CHU Clermont-Ferrand, Department of Neurology, CHU Gabriel Montpied, Clermont-Ferrand, France.|Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ulla
authors.affiliation: University, Hospital Toulouse, Neurology department, CHU Purpan, Toulouse, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Brefel-Courbon
authors.affiliation: University, Hospital Toulouse, Neurology department, CHU Purpan, Toulouse, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Ory-Magne
authors.affiliation: Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France.
authors.forename: Kathy
authors.initials: K
authors.lastname: Dujardin
authors.affiliation: University of Bordeaux, Institut des Maladies Neurodégénératives, CNRS UMR 5293 et CHU de Bordeaux, France.
authors.forename: François
authors.initials: F
authors.lastname: Tison
authors.affiliation: Movement Disorder Unit, Department of Psychiatry and Neurology, CHU de Grenoble, Joseph Fourier University and INSERM, Unité 836, Grenoble Institut des Neurosciences, 38043 Grenoble, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Krack
authors.affiliation: CHU Clermont-Ferrand, Department of Neurology, CHU Gabriel Montpied, Clermont-Ferrand, France.|Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Durif
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology / Q000523:psychology*; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology / Q000523:psychology*; D010300:Parkinson Disease / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*
keywords: Parkinson’s disease; impulse control disorders; mood disorders; quality of life