title: Quaternary cocrystals: combinatorial synthetic strategies based on long-range synthon Aufbau modules (LSAM).
abstract: A synthetic strategy is outlined whereby a binary cocrystal may be developed in turn into a ternary and finally into a quaternary cocrystal. The strategy hinges on the concept of the long-range synthon Aufbau module (LSAM) which is a large supramolecular synthon containing more than one type of intermolecular interaction. Modulation of these interactions may be possible with the use of additional molecular components so that higher level cocrystals are produced. We report six quaternary cocrystals here. All are obtained as nearly exclusive crystallization products when four appropriate solid compounds are taken together in solution for crystallization.
authors.affiliation: Solid State and Structural Chemistry Unit, Indian Institute of Science , Bangalore 560 012, India.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Dubey
authors.affiliation: Solid State and Structural Chemistry Unit, Indian Institute of Science , Bangalore 560 012, India.
authors.forename: Niyaz A
authors.initials: NA
authors.lastname: Mir
authors.affiliation: Solid State and Structural Chemistry Unit, Indian Institute of Science , Bangalore 560 012, India.
authors.forename: Gautam R
authors.initials: GR
authors.lastname: Desiraju
keywords: cocrystals; crystal design; crystal engineering; inermolecular interactions; long-range synthon Aufbau module; polymorphism