title: Platelet-Rich Plasma Gel Combined with Bovine-Derived Xenograft for the Treatment of Dehiscence Around Immediately Placed Conventionally Loaded Dental Implants in Humans: Cone Beam Computed Tomography and Three-Dimensional Image Evaluation.
abstract: OBJECTIVE
  This study clinically and radiographically investigated the potential of platelet-rich plasma (PRP) gel combined with bovine-derived xenograft to treat dehiscence defects around immediate dental implants.
  
  
  METHODS
  This study was performed on 32 sites from 16 patients who each received an immediate implant for a single tooth replacement at a maxillary anterior or premolar site. Patients were divided into two groups according to the augmented materials used. One group received an immediate implant and filling of defects using a PRP gel plus bovine-derived xenograft. The other group received an immediate implant and filling of defects with a bovine-derived xenograft without PRP gel. Cone beam computed tomography (CBCT) was taken before placement, and at 6 and 12 months postsurgery.
  
  
  RESULTS
  Both treatment procedures resulted in significant improvements for the primary outcome regarding bone fill, as well as the marginal bone level. In addition, statistically significant differences were found in the bone density for the combined therapy compared with sites treated with bovine-derived xenografts alone (P ≤ .01).
  
  
  CONCLUSIONS
  Autogenous PRP gel combined with bovine-derived xenograft demonstrated superiority to the bovine-derived xenograft alone, which suggested that it could be successfully applicable for the treatment of dehiscence around an immediate dental implant. Moreover, CBCT can be used to measure dehiscence and to assess bone thickness along the implant.
authors.forename: Aws
authors.initials: A
authors.lastname: ArRejaie
authors.forename: Fahad
authors.initials: F
authors.lastname: Al-Harbi
authors.forename: Adel S
authors.initials: AS
authors.lastname: Alagl
authors.forename: Khalid S
authors.initials: KS
authors.lastname: Hassan
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000818:Animals; D015519:Bone Density / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D019250:Dental Implants, Single-Tooth; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D064593:Heterografts / Q000637:transplantation*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000601:surgery; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000502:physiology*; D020390:Tooth Socket / Q000000981:diagnostic imaging / Q000601:surgery; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D005782:Gels; D008903:Minerals