title: Leveraging immunotherapy for the treatment of gynecologic cancers in the era of precision medicine.
abstract: During the past decade significant progress in the understanding of stimulatory and inhibitory signaling pathways in immune cells has reinvigorated the field of immuno-oncology. In this review we outline the current immunotherapy based approaches for the treatment of gynecological cancers, and focus on the emerging clinical data on immune checkpoint inhibitors, adoptive cell therapies, and vaccines. It is anticipated that in the coming years biomarker-guided clinical trials, will provide for a better understanding of the mechanisms of response and resistance to immunotherapy, and guide combination treatment strategies that will extend the benefit from immunotherapy to patients with gynecologic cancers.
authors.affiliation: Department of Medicine, Gynecologic Medical Oncology Service, Memorial Sloan Kettering Cancer Center, United States.
authors.forename: Dmitriy
authors.initials: D
authors.lastname: Zamarin
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, University of Texas, MD Anderson Cancer Center, United States. Electronic address: aajazaeri@mdanderson.org.
authors.forename: Amir A
authors.initials: AA
authors.lastname: Jazaeri
mesh_terms: D060908:CTLA-4 Antigen / Q000502:physiology; D019496:Cancer Vaccines / Q000627:therapeutic use; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D016219:Immunotherapy, Adoptive; D008213:Lymphocyte Activation; D050130:Oncolytic Virotherapy; D057285:Precision Medicine; D061026:Programmed Cell Death 1 Receptor / Q000037:antagonists & inhibitors; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D060908:CTLA-4 Antigen; D019496:Cancer Vaccines; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor
keywords: Cervical cancer; Checkpoint inhibitors; Endometrial cancer; Gynecologic cancers; Immuno-oncology; Immunotherapy; Ovarian cancer