title: Surgical Management of Clostridium difficile Infection: The Role of Colectomy.
abstract: Management of Clostridium difficile infections is usually accomplished through appropriate antimicrobial therapy. However, in patients that do not respond to this therapy, rapid and potentially lethal progressive organ dysfunction care occurs. Although supportive care and continued antimicrobial therapy is important, surgical therapy is critical to eradication of the inflammatory process and reversal of the dysregulated immunity associated with severe C. difficile infections. In the following paper, the role of colectomy is reviewed.
authors.affiliation: 1 Department of Surgery, University of Michigan , Ann Arbor, Michigan.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Delano
authors.affiliation: 1 Department of Surgery, University of Michigan , Ann Arbor, Michigan.|2 Department of Surgery, University of Washington , Seattle, Washington.
authors.forename: Joseph
authors.initials: J
authors.lastname: Cuschieri
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000601:surgery*; D003082:Colectomy; D003131:Combined Modality Therapy; D006801:Humans; D007081:Ileostomy
chemical_list: D000900:Anti-Bacterial Agents