title: Intermolecular dearomative C2-arylation of N-Ac indoles activated by FeCl3.
abstract: We report the FeCl3-mediated direct addition of electron-rich arenes to the C2-position of electrophilic N-Ac indoles under mild conditions (room temperature, air). No functional group is required on the arene nucleophile: one of its C-H bonds is added to the C2[double bond, length as m-dash]C3 double bond of the indole nucleus in a Friedel-Crafts-type reaction. This dearomatisation process delivered a broad range of C2-arylated indolines.
authors.affiliation: Univ Paris Sud, CNRS, Université Paris-Saclay, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe Méthodologie, Synthèse et Molécules Thérapeutiques (MS&MT), Orsay, 91405, France. guillaume.vincent@u-psud.fr.
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Nandi
authors.forename: Friederike
authors.initials: F
authors.lastname: Ratsch
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Beaud
authors.forename: Régis
authors.initials: R
authors.lastname: Guillot
authors.forename: Cyrille
authors.initials: C
authors.lastname: Kouklovsky
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vincent