title: Data on biodistribution and radiation absorbed dose profile of a novel (64)Cu-labeled high affinity cell-specific peptide for positron emission tomography imaging of tumor vasculature.
abstract: New peptide-based diagnostic and therapeutic approaches hold promise for highly selective targeting of cancer leading to more precise and effective diagnostic and therapeutic modalities. An important feature of these approaches is to reach the tumor tissue while limiting or minimizing the dose to normal organs. In this context, efforts to design and engineer materials with optimal in vivo targeting and clearance properties are important. This Data In Brief article reports on biodistribution and radiation absorbed dose profile of a novel high affinity radiopeptide specific for bone marrow-derived tumor vasculature. Background information on the design, preparation, and in vivo characterization of this peptide-based targeted radiodiagnostic is described in the article "Synthesis and comparative evaluation of novel 64Cu-labeled high affinity cell-specific peptides for positron emission tomography of tumor vasculature" (Merrill et al., 2016) [1]. Here we report biodistribution measurements in mice and calculate the radiation absorbed doses to normal organs using a modified Medical Internal Radiation Dosimetry (MIRD) methodology that accounts for physical and geometric factors and cross-organ beta doses.
authors.affiliation: Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Merrill
authors.affiliation: Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Krajewski
authors.affiliation: Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Frank
authors.affiliation: Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Lalush
authors.affiliation: NewYork Presbyterian Hospital, Weill Cornell Medical Center, New York, NY 10065, USA.
authors.forename: Cam
authors.initials: C
authors.lastname: Patterson
authors.affiliation: Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695, USA; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Anka N
authors.initials: AN
authors.lastname: Veleva
keywords: Diagnostic radiopharmaceuticals; Molecular imaging; Radiation absorbed dose; Tumor angiogenesis