title: Examining the Clinical Effectiveness of Non-Carbapenem β-Lactams for the Treatment of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae.
abstract: Treatment options for extended-spectrum β-lactamase-producing Enterobacteriaceae are limited. Piperacillin-tazobactam and cefepime represent potential alternative treatment options; however, large prospective studies are lacking. This review evaluates the current literature regarding use of piperacillin-tazobactam and cefepime for the treatment of extended-spectrum β-lactamase-producing Enterobacteriaceae. Antimicrobial stewardship programs can play a key role in guiding the best practices for the management of these challenging infections.
authors.affiliation: Department of Pharmacy, Froedtert &amp; The Medical College of Wisconsin, 9200 W. Wisconsin Ave, Milwaukee, WI 53226, USA. allison.gibble@froedtert.com.
authors.forename: Allison M
authors.initials: AM
authors.lastname: Gibble
authors.affiliation: Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, 833 S. Wood St., 164 PHARM, Chicago, IL 60612, USA. aegross@uic.edu.
authors.forename: Alan E
authors.initials: AE
authors.lastname: Gross
authors.affiliation: Department of Pharmacy, Froedtert &amp; The Medical College of Wisconsin, 9200 W. Wisconsin Ave, Milwaukee, WI 53226, USA. angela.huang@froedtert.com.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Huang
keywords: carbapenems; cefepime; extended-spectrum beta-lactamases; piperacillin-tazobactam