title: Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis
abstract: Chronic kidney disease (CKD) patients often have gastrointestinal symptoms which may result in malnutrition and a negative impact on their quality of life. Modulation of the gut microbiota can be a strategy to promote host health and homeostasis.
  
  
  
  The authors present a case of chronic diarrhea in a hemodialysis (HD) patient with an unknown etiology. After about one year and several failed interventions, synbiotic therapy was performed. The diarrhea episodes ceased after three months of daily supplementation and both biochemical and nutritional parameters improved. Synbyotic therapy promoted clinical benefits in this patient.
  
  
  
  Therefore, this simple therapy may be a promising alternative in CKD and it should be tested in larger studies.
authors.affiliation: Medical Sciences Graduate Program, Federal University Fluminenses (UFF), Niterói, Rio de Janeiro, Brazil. nat_borges_@hotmail.com
authors.forename: Natalia
authors.initials: N
authors.lastname: Alvarenga Borges
authors.forename: Najla
authors.initials: N
authors.lastname: Elias Farage
authors.forename: Amanda
authors.initials: A
authors.lastname: Faria Barros
authors.forename: Dennis
authors.initials: D
authors.lastname: Carvalho Ferreira
authors.forename: Denis
authors.initials: D
authors.lastname: Fouque
authors.forename: Denise
authors.initials: D
authors.lastname: Mafra
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003967:Diarrhea / Q000178:diet therapy* / Q000209:etiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000178:diet therapy* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D058616:Synbiotics; D016896:Treatment Outcome
keywords: Chronic kidney disease; Diarrhea; Hemodialysis; Microbiota; Synbiotics