title: [Pharmacogenomics of severe drug hypersensitivity reactions--from bench to bedside].
abstract: Recent remarkable findings of pharmacogenomics and basic scientific research provided insights in the pathogenesis of severe drug hypersensitivity reactions such as drug rush with eosinophilia and systemic symptoms (DRESS), abacavir hypersensitivity syndrome or blistering reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis). There is increasing evidence for the strong associations of certain human leukocyte antigen (HLA) alleles with hypersensitivity to particular drugs. HLA genes may serve as genomic biomarkers of predisposition to severe adverse drug reactions and enable to prevent them. In this paper we review essentials and advances in this area.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Porębski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Dyga
authors.forename: Marcin
authors.initials: M
authors.lastname: Stobiecki
authors.forename: Ewa
authors.initials: E
authors.lastname: Czarnobilska
mesh_terms: D004342:Drug Hypersensitivity / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans
chemical_list: D006680:HLA Antigens