title: Tying up loose ends: telomeres, genomic instability and lamins.
abstract: On casual inspection, the eukaryotic nucleus is a deceptively simple organelle. Far from being a bag of chromatin, the nucleus is, in some ways, a structural and functional extension of the chromosomes it contains. Recently, interest has intensified in how chromosome compartmentalization and dynamics affect nuclear function. Different studies uncovered functional interactions between chromosomes and the filamentous nuclear meshwork comprised of lamin proteins. Here, we summarize recent research suggesting that telomeres, the capping structures that protect chromosome ends, are stabilized by lamin-binding and that alterations in nuclear lamins lead to defects in telomere compartmentalization, homeostasis and function. Telomere dysfunction contributes to the genomic instability that characterizes aging-related diseases, and might be an important factor in the pathophysiology of lamin-related diseases.
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, 1100 South Grand Blvd., St. Louis, MO 63104, USA. Electronic address: sgonzalo@slu.edu.
authors.forename: Susana
authors.initials: S
authors.lastname: Gonzalo
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, 1100 South Grand Blvd., St. Louis, MO 63104, USA.
authors.forename: Joel C
authors.initials: JC
authors.lastname: Eissenberg
mesh_terms: D002467:Cell Nucleus / Q000235:genetics; D002843:Chromatin / Q000235:genetics; D002875:Chromosomes / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D042822:Genomic Instability; D006801:Humans; D034882:Lamins / Q000235:genetics*; D016615:Telomere / Q000235:genetics*
chemical_list: D002843:Chromatin; D034882:Lamins