title: 3D hydrogel scaffold doped with 2D graphene materials for biosensors and bioelectronics.
abstract: Hydrogels consisting of three-dimensional (3D) polymeric networks have found a wide range of applications in biotechnology due to their large water capacity, high biocompatibility, and facile functional versatility. The hydrogels with stimulus-responsive swelling properties have been particularly instrumental to realizing signal transduction in biosensors and bioelectronics. Graphenes are two-dimensional (2D) nanomaterials with unprecedented physical, optical, and electronic properties and have also found many applications in biosensors and bioelectronics. These two classes of materials present complementary strengths and limitations which, when effectively coupled, can result in significant synergism in their electrical, mechanical, and biocompatible properties. This report reviews recent advances made with hydrogel and graphene materials for the development of high-performance bioelectronics devices. The report focuses on the interesting intersection of these materials wherein 2D graphenes are hybridized with 3D hydrogels to develop the next generation biosensors and bioelectronics.
authors.affiliation: Korea Division of Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Yuseong, Daejeon 169-148, Republic of Korea.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Song
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, Daejeon 305-600, Republic of Korea.
authors.forename: Oh Seok
authors.initials: OS
authors.lastname: Kwon
authors.affiliation: Department of Chemical and Environmental Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT 06511, USA.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA; School of Engineering and Materials Science, Queen Mary University of London, London, UK. Electronic address: jdconde@mit.edu.
authors.forename: João
authors.initials: J
authors.lastname: Conde
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Biomedical Engineering Division, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. Electronic address: nartzi@mit.edu.
authors.forename: Natalie
authors.initials: N
authors.lastname: Artzi
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D025802:Electric Capacitance; D062609:Electronic Nose; D004581:Electronics / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D014173:Transistors, Electronic
chemical_list: D020100:Hydrogels; D006108:Graphite
keywords: 2D materials; 3D materials; Biosensors; Graphene; Hydrogels; Nanodevices