title: [PLACE REMAXOL AS A HEPATOPROTECTOR IN INTENSIVE THERAPY OF PERVASIVE PERITONITIS].
abstract: PERPOSE OF RESEARCH: to evaluate the effectiveness of Remaxol in patients with pervasive peritonitis.
  
  
  METHODS
  assessed the effectiveness of a balanced infusion of the drug (Remaxol) in the treatment of 44 patients agedfrom 18 to 50 years. Patients were devided into 2 groups by the method of envelopes. All patients received a comprehensive differential therapy: 21 patient 1 group consisting of infusion therapy in the postoperative period received Remaxol at a dose of 800 mg/day for 7 days.
  
  
  RESULTS
  the comporative assessment of indicators of systemic hemodinamics, oxygen transport, asid base status, glucose, lactose and free radical oxydation. Patients on the first background was used Remaxol have experiensed a more rapid relief of metabolic disorders, endotoxemia and hepatic dysfunction compared with the indices of the 2 group patients. Noted earlier stabilization of rudicators of systemic hemodynamics and oxygen transport. This has reduced the duration of respiratory and vasopressor suppot, early start ofparenteral intreduction in case the power (p < 0.05).
  
  
  CONCLUSIONS
  this study shows that use of the drug for the purpose of relief Remaxol hepatic dysfunction and prevention of drug liver toxicity in conditions ofperitonitis, after 48 hours of operation, provides a positive dynamics and stabilization ofparameters of central hemodynamics, contributing to the abolition of vasopressor support, and contributes to the effective utilization of oxygen, while providing antioxidant effect.
authors.forename: Yu P
authors.initials: YP
authors.lastname: Orlov
authors.forename: V N
authors.initials: VN
authors.lastname: Lukach
authors.forename: N V
authors.initials: NV
authors.lastname: Govorova
authors.forename: A V
authors.initials: AV
authors.lastname: Gluschenko
authors.forename: O D
authors.initials: OD
authors.lastname: Dmitriva
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D003422:Critical Care / Q000379:methods*; D005609:Free Radicals / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000601:surgery*; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000975:Antioxidants; D005609:Free Radicals; C555877:Remaxol; D013386:Succinates