title: Amitorines A and B, Nitrogenous Diterpene Metabolites of Theonella swinhoei: Isolation, Structure Elucidation, and Asymmetric Synthesis.
abstract: Two new nitrogenous prenylbisabolanes never before found in Lithistid sponges have been isolated from Theonella swinhoei. These new diterpenes, named amitorine A (1) and amitorine B (2), containing a prenylbisabolane skeleton have been characterized by spectroscopic analyses, and the relative and absolute configurations of 1 and 2 were determined by asymmetric synthesis of both diastereomers via the common bicyclic lactone 6 intermediate.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ota
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hamamoto
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Wakiko
authors.initials: W
authors.lastname: Eda
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Tamura
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Sawada
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Hoshino
authors.affiliation: College of Pharmaceutical Sciences, Matsuyama University , 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Mitome
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kamaike
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyaoka
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047232:Theonella / Q000737:chemistry*
chemical_list: D004224:Diterpenes; C000610550:amitorine A; C000610551:amitorine B; C503654:prenylbisabolane