title: Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression.
authors.affiliation: Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, 68178, USA.
authors.forename: Chuu-Yun A
authors.initials: CY
authors.lastname: Wong
authors.affiliation: Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, 68178, USA.
authors.forename: Haihong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, 68178, USA.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Abel
authors.affiliation: Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, 68178, USA.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Scofield
authors.affiliation: Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, 68178, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xie
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. weitt@moon.ibp.ac.cn.
authors.forename: Taotao
authors.initials: T
authors.lastname: Wei
authors.affiliation: Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, 68178, USA. Yat60399@creighton.edu.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Tu
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D015536:Down-Regulation / Q000187:drug effects*; D005260:Female; D020662:Guanine Nucleotide Exchange Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D061986:MCF-7 Cells; D008301:Maleimides / Q000494:pharmacology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D007211:Indoles; D008301:Maleimides; D020033:Protein Isoforms; D011493:Protein Kinase C; D034741:RNA, Small Interfering; D018719:Erb-b2 Receptor Tyrosine Kinases; D013755:Tetradecanoylphorbol Acetate; C465664:2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide; C453280:PREX1 protein, human; C508053:ERBB2 protein, human