title: CASTORing New Light on Amino Acid Sensing.
abstract: The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.
authors.affiliation: Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston MA, USA.
authors.forename: James E Hughes
authors.initials: JEH
authors.lastname: Hallett
authors.affiliation: Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston MA, USA. Electronic address: bmanning@hsph.harvard.edu.
authors.forename: Brendan D
authors.initials: BD
authors.lastname: Manning
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D008027:Light; D015398:Signal Transduction
chemical_list: D000596:Amino Acids