title: Prognostication Value of Descending Corticospinal Tract DWI Signal in Neonatal Cerebral Sinovenous Thrombosis.
abstract: Descending corticospinal tract diffusion-weighted magnetic resonance imaging (MRI) signal is predictive of poor motor outcome in neonatal and childhood arterial ischemic stroke. However, descending corticospinal tract diffusion-weighted MRI signal has not been documented in the setting of cerebral sinovenous thrombosis, and its role is not understood.
  
  
  
  We describe a neonate with cerebral sinovenous thrombosis, extensive diffusion restriction, and bilateral descending corticospinal tract diffusion-weighted MRI signal on MRI of the brain. We discuss the underlying mechanisms and implications of these findings in venous ischemia.
  
  
  
  The prognostic value of descending corticospinal tract diffusion-weighted MRI signal differs when observed in cerebral sinovenous thrombosis from when observed in arterial ischemic stroke. Consequently, caution should be exercised in using descending corticospinal tract diffusion-weighted MRI signal to predict outcome in children with cerebral sinovenous thrombosis.
authors.affiliation: Neurologie pédiatrique, CHU Sainte-Justine, Université de Montréal, Montreal, Ontario, Canada.
authors.forename: Matsanga Leyila
authors.initials: ML
authors.lastname: Kaseka
authors.affiliation: Stroke Program, Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Mahendranath
authors.initials: M
authors.lastname: Moharir
authors.affiliation: Stroke Program, Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: deVeber
authors.affiliation: Stroke Program, Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Daune
authors.initials: D
authors.lastname: MacGregor
authors.affiliation: Stroke Program, Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Rand
authors.initials: R
authors.lastname: Askalan
authors.affiliation: Stroke Program, Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: nomazulu.dlamini@sickkids.ca.
authors.forename: Nomazulu
authors.initials: N
authors.lastname: Dlamini
mesh_terms: D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging*; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology
keywords: CSVT; DCST DWI; cerebral sinovenous thrombosis; descending corticospinal tract; neonatal; outcome; prognosis; stroke