title: Reelin Signaling in the Migration of Ventral Brain Stem and Spinal Cord Neurons.
abstract: The extracellular matrix protein Reelin is an important orchestrator of neuronal migration during the development of the central nervous system. While its role and mechanism of action have been extensively studied and reviewed in the formation of dorsal laminar brain structures like the cerebral cortex, hippocampus, and cerebellum, its functions during the neuronal migration events that result in the nuclear organization of the ventral central nervous system are less well understood. In an attempt to delineate an underlying pattern of Reelin action in the formation of neuronal cell clusters, this review highlights the role of Reelin signaling in the migration of neuronal populations that originate in the ventral brain stem and the spinal cord.
authors.affiliation: Neurodevelopmental Genetics, Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn Bonn, Germany.
authors.forename: Ankita R
authors.initials: AR
authors.lastname: Vaswani
authors.affiliation: Neurodevelopmental Genetics, Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn Bonn, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Blaess
keywords: Dab1; cranial motor neurons; dopaminergic neurons; hindbrain; midbrain; mouse models; preganglionic neurons; somatic motor neurons