title: Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease.
abstract: OBJECTIVE
  We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score.
  
  
  METHODS
  In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were classified into two groups, low SYNTAX score (≤22) and high SYNTAX score (≥23).
  
  
  RESULTS
  MHRs were significantly higher in patients with high SYNTAX score (p < 0.05). In multivariate regression analysis, MHR remained as independent predictor of high SYNTAX score together with C-reactive protein (CRP), hypertension and diabetes mellitus. In correlation analysis, MHR showed significant positive correlations with SYNTAX score (r = 0.371, p < 0.001) and CRP level (r = 0.336, p < 0.001).
  
  
  CONCLUSIONS
  This study suggests MHR is independently associated with burden of coronary atherosclerosis.
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboga
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Kevser Gulcihan
authors.initials: KG
authors.lastname: Balci
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Maden
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Ahmet Goktug
authors.initials: AG
authors.lastname: Ertem
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kirbas
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Yayla
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Acar
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Kisacik
authors.affiliation: Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydogdu
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007249:Inflammation; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology* / Q000378:metabolism; D015999:Multivariate Analysis; D016017:Odds Ratio; D018384:Oxidative Stress; D012044:Regression Analysis; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D008076:Cholesterol, HDL; D002097:C-Reactive Protein
keywords: high SYNTAX score; inflammation/oxidative stress; monocyte/HDL-cholesterol ratio