title: Coenzyme Q and Its Role in the Dietary Therapy against Aging.
abstract: Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is particularly abundant. Since then, more additional roles in cell physiology have been reported, including antioxidant, signaling, death prevention, and others. It is known that all cells are able to synthesize functionally sufficient amounts of CoQ under normal physiological conditions. However, CoQ is a molecule found in different dietary sources, which can be taken up and incorporated into biological membranes. It is known that mitochondria have a close relationship with the aging process. Additionally, delaying the aging process through diet has aroused the interest of scientists for many years. These observations have stimulated investigation of the anti-aging potential of CoQ and its possible use in dietary therapies to alleviate the effects of aging. In this context, the present review focus on the current knowledge and evidence the roles of CoQ cells, its relationship with aging, and possible implications of dietary CoQ in relation to aging, lifespan or age-related diseases.
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center (CIBM), University of Granada, Avda. del Conocimiento s.n., Armilla, Granada 18100, Spain. avarelalopez@gmail.com.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Varela-López
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO), Facoltà di Medicina, Università Politecnica delle Marche, Ancona 60131, Italy. f.giampieri@univpm.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giampieri
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO), Facoltà di Medicina, Università Politecnica delle Marche, Ancona 60131, Italy. m.a.battino@univpm.it.|Centre for Nutrition &amp; Health, Universidad Europea del Atlantico (UEA), Santander 39011, Spain. m.a.battino@univpm.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center (CIBM), University of Granada, Avda. del Conocimiento s.n., Armilla, Granada 18100, Spain. jlquiles@ugr.es.
authors.forename: José L
authors.initials: JL
authors.lastname: Quiles
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D004035:Diet Therapy; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D014451:Ubiquinone / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D014451:Ubiquinone
keywords: aging; antioxidants; diet; mitochondria; nutrition; oxidative stress; ubiquinone