title: The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.
abstract: Nanoparticle-based technologies offer exciting new approaches to disease diagnostics and therapeutics. To take advantage of unique properties of nanoscale materials and structures, the size, shape and/or surface chemistry of nanoparticles need to be optimized, allowing their functionalities to be tailored for different biomedical applications. Here we review the effects of nanoparticle size on cellular interaction and in vivo pharmacokinetics, including cellular uptake, biodistribution and circulation half-life of nanoparticles. Important features of nanoparticle probes for molecular imaging and modeling of nanoparticle size effects are also discussed.
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Hoshyar
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Gray
authors.affiliation: Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Han
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.|Department of Bioengineering, Rice University, Houston, TX 77030, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Bao
mesh_terms: D000818:Animals; D006207:Half-Life; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D057054:Molecular Imaging / Q000379:methods; D053758:Nanoparticles / Q000032:analysis* / Q000378:metabolism*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D010316:Particle Size; D014018:Tissue Distribution
keywords: cellular uptake; in vivo pharmacokinetics; modeling; nanoparticle; size effect