title: Gut Microbiota: A Key Modulator of Intestinal Healing in Inflammatory Bowel Disease.
abstract: Mucosal healing (MH) represents a crucial factor for maintaining gut homeostasis. Indeed, in inflammatory bowel disease, MH has become the standard therapeutical target, because it is associated with more effective disease control, more frequent steroid-free remission, lower rates of hospitalization and surgery, and improved quality of life. In this scenario, gut microbiota is a crucial player in modulating intestinal repair and regeneration process. It can act on the tumor necrosis factor-α production, modulation of reactive oxygen and nitrogen species, activity of matrix metalloproteinases and on many other mechanisms strictly involved in restoring gut health. In this review, we analyze and review the literature on the role of gut microbiota in sustaining mucosal injury and achieving MH.
authors.affiliation: Internal Medicine Department, Gastroenterology Division, Catholic University of Sacred Hearth, Rome, Italy.
authors.forename: L R
authors.initials: LR
authors.lastname: Lopetuso
authors.forename: V
authors.initials: V
authors.lastname: Petito
authors.forename: D
authors.initials: D
authors.lastname: Zambrano
authors.forename: D
authors.initials: D
authors.lastname: Orlando
authors.forename: A
authors.initials: A
authors.lastname: Dal Lago
authors.forename: L
authors.initials: L
authors.lastname: Serrichhio
authors.forename: A
authors.initials: A
authors.lastname: Papa
authors.forename: A
authors.initials: A
authors.lastname: Gasbarrini
authors.forename: F
authors.initials: F
authors.lastname: Scaldaferri
mesh_terms: D001419:Bacteria / Q000378:metabolism; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000382:microbiology* / Q000473:pathology*; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D007422:Intestines / Q000382:microbiology* / Q000473:pathology / Q000502:physiology*; D014945:Wound Healing