title: [Clinical Efficacy of Crizotinib in Treatment of Patients with Advanced NSCLC].
abstract: OBJECTIVE
  Crizotinib was developed in recent years based on targets of anaplastic lymphoma kinase (ALK) fusion genes. The aim of this study is to explore the efficacy of crizotinib in treatment of non-small cell lung cancer (NSCLC) with ALK/ROS1 rearrangement.
  
  
  METHODS
  Retrospective analysis of 40 patients with ALK/ROS1-positive NSCLC, who received treatment in Beijing Cancer Hospital during the period from Jun. 2013 to Dec. 2014.
  
  
  RESULTS
  Among these cases, 39 were adenocarcinoma and adenosquamous carcinoma, with characters involving signet-ring cell carcinoma, polypoid adenocarcinoma, acini and papillary adenocarcinoma. The median age was 49.5 years old, with the overall response rate of 62.5% and disease control rate of 95.0%. Of all the cases, median follow-up was 14.6 months and median PFS 7.5 months; median OS has not been reached; the one-year survival rate was 77.4%. The median PFS and OS of patients receiving first and second-line treatment tend to be longer than those who received post-second line treatment, but with no statistical significance (PFS: 9 mo vs 6 mo, P=0.06; OS: 21.5 mo vs 14.6 mo, P=0.12). Twenty patients who experienced progression in brain metastases. After experiencing progression, the patients receiving 2nd/3rd generation ALK-TKI treatment showed efficacy of disease control and survival. The adverse events include gastrointestinal reaction, transaminase elevation, and distinctive visual abnormalities, etc.
  
  
  CONCLUSIONS
  The clinical features, efficacy, and adverse events of crizotinib in the treatment of the 40 patients with ALK/ROS1-positive NSCLC are similar to the data from the previous reports. The most common site of progression was brain metastases. The treatment of crizotinib-resistant patients using 2nd/3rd generation ALK-TKI could delay progression.
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Emei
authors.initials: E
authors.lastname: Gao
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Minglei
authors.initials: M
authors.lastname: Zhuo
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: An
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Meina
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Respiratory Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhong
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000077547:Crizotinib; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000008:administration & dosage* / Q000009:adverse effects; D011725:Pyridines / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib