title: Adult-onset Leigh's disease: A rare entity.
abstract: Leigh syndrome (LS) is a heterogeneous familial or sporadic neurodegenerative disorder. It is typically seen in infancy or childhood, although rare cases of adult onset have been described. The authors describe a 37-year-old woman who presented with protracted gastrointestinal symptoms followed by acute brain stem syndrome with severe metabolic acidosis and who subsequently showed dramatic clinical and neuroradiological improvement.
authors.affiliation: Department of Neurology, Millennium Block, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.
authors.forename: Shaik Afshan
authors.initials: SA
authors.lastname: Jabeen
authors.affiliation: Department of Neurology, Millennium Block, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Sandeep
authors.affiliation: Department of Neurology, Millennium Block, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.
authors.forename: Kandadai Rukmini
authors.initials: KR
authors.lastname: Mridula
authors.affiliation: Department of Neurology, Millennium Block, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.
authors.forename: Angamuttu Kanikannan
authors.initials: AK
authors.lastname: Meena
authors.affiliation: Department of Neurology, Millennium Block, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.
authors.forename: Rupam
authors.initials: R
authors.lastname: Borgohain
authors.affiliation: Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.
authors.forename: Challa
authors.initials: C
authors.lastname: Sundaram
keywords: Adult onset; Leigh's disease; brain stem hyperintensities; bulbar palsy; serum lactate