title: [Adaptation to the availability of essential amino-acids: role of GCN2/eIF2α/ATF4 pathway].
abstract: In mammals, metabolic adaptations are required to overcome nutritional deprivation in amino-acids/proteins as well as episodes of malnutrition. GCN2 protein kinase, which phosphorylates the α subunit of the translation initiation factor eIF2, is a sensor of amino-acid(s) deficiencies. On one hand, this review briefly describes the main features of amino-acid metabolism. On the other hand, it describes the role of GCN2 in regulating numerous physiological functions.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fafournoux
authors.forename: Julien
authors.initials: J
authors.lastname: Averous
authors.forename: Alain
authors.initials: A
authors.lastname: Bruhat
authors.forename: Valérie
authors.initials: V
authors.lastname: Carraro
authors.forename: Céline
authors.initials: C
authors.lastname: Jousse
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Maurin
authors.forename: Florent
authors.initials: F
authors.lastname: Mesclon
authors.forename: Laurent
authors.initials: L
authors.lastname: Parry
mesh_terms: D000220:Adaptation, Biological / Q000502:physiology*; D000596:Amino Acids; D000601:Amino Acids, Essential / Q000008:administration & dosage* / Q000172:deficiency; D000818:Animals; D004032:Diet; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007109:Immunity; D044342:Malnutrition; D009473:Neuronal Plasticity; D009752:Nutritional Status; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000596:Amino Acids; D000601:Amino Acids, Essential; D015852:Eukaryotic Initiation Factor-2; C529271:EIF2AK4 protein, human; D017346:Protein Serine-Threonine Kinases