title: Comparative effectiveness of natural and synthetic bone grafts in oral and maxillofacial surgery prior to insertion of dental implants: Systematic review and network meta-analysis of parallel and cluster randomized controlled trials.
abstract: OBJECTIVE
  Bone grafts are often used to enhance bone volume/quality prior to implantation insertion. This systematic review compares the histomorphometric effectiveness of bone grafts in an evidence-based manner.
  
  
  METHODS
  Randomized clinical trials comparing histomorphometrically the % of newly-formed bone between two grafts were included. Risk of bias within and across studies was assessed with the Cochrane tool and the GRADE approach, respectively. Random-effects pairwise meta-analyses were conducted, followed by network meta-analysis, network meta-regression and sensitivity analyses.
  
  
  METHODS
  Four electronic databases were searched from inception to June 2015 without limitations.
  
  
  METHODS
  A total of 12 trials (5 parallel; 7 cluster) with a total of 231 patients (302 grafted sites) were included. No statistically significant differences were found in the % of new bone from pairwise comparisons between any two bone grafts. Treatment ranking based on the evidence network indicated that autografts presented the highest percentage of new bone, followed by synthetic grafts, xenografts, and allografts. No differences according to patient age, sex, healing time, membrane used or kind of surgical graft use were identified. Our confidence on pairwise comparisons was moderate to very low due to study limitations, inconsistency, and imprecision; our confidence on graft ranking was moderate due to study limitations.
  
  
  CONCLUSIONS
  No significant differences were found in the percentage of new bone between any two grafts.
  
  
  CONCLUSIONS
  Synthetic bone substitutes or xenologous bone grafts can be used as an alternative to autologous graft in order to overcome problems of additional surgeries or limited graft availability.
authors.affiliation: Department of Orthodontics, School of Dentistry, University of Bonn, Bonn 53111, Germany; Department of Oral Technology, School of Dentistry, University of Bonn, Bonn 53111, Germany. Electronic address: snpapage@gmail.com.
authors.forename: Spyridon N
authors.initials: SN
authors.lastname: Papageorgiou
authors.affiliation: Department of Neurosciences, Southampton University Hospital, Tremona Road, SO16 6YD Southampton, UK.
authors.forename: Panagiotis N
authors.initials: PN
authors.lastname: Papageorgiou
authors.affiliation: Section for Experimental Dento-Maxillo-Facial Medicine, School of Dentistry, University of Bonn, Bonn 53111, Germany.
authors.forename: James
authors.initials: J
authors.lastname: Deschner
authors.affiliation: Department of Orthodontics, School of Dentistry, University of Bonn, Bonn 53111, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Götz
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D059546:Sinus Floor Augmentation / Q000379:methods; D013515:Surgery, Oral / Q000379:methods*; D014081:Tooth Extraction / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants
keywords: Alveolar ridge augmentation; Bone grafting; Bone substitutes; Network meta-analysis; Randomized controlled trial; Sinus floor augmentation; Systematic review; Tooth extraction