title: COMPARATIVE STUDY OF THE EFFECTS OF LOW-LEVEL LASER AND LOW-INTENSITY ULTRASOUND ASSOCIATED WITH BIOSILICATE(®) ON THE PROCESS OF BONE REPAIR IN THE RAT TIBIA.
abstract: OBJECTIVE
  Verify the effects of the association between Biosilicate® and ultrasound and, Biosilicate® and laser in bone consolidation process of rats, through the biomechanical and histological analysis.
  
  
  METHODS
  Forthy male rats were used. The animals were randomized into four groups (n=10): control group fracture no treated (CGF); group treated with Biosilicate® (BG); group treated with Biosilicate® and laser (BLG); group treated with Biosilicate® and ultrasound (BUG).
  
  
  RESULTS
  The biomechanical analysis showed no significant difference among any groups after 14 days post-surgery. In the morphometric analysis, the control group showed moderate presence of new formed bone tissue inside the defects areas and the Biosilicate® group showed similar results. Despite those facts, the biomaterial osteogenic potential was demonstrated by the great amount of cells and bone tissue around the particles. Curiously, the Biosilicate® plus laser or ultrasound groups showed lower amounts of bone tissue deposition when compared with control fracture and Biosilicate® groups.
  
  
  CONCLUSIONS
  The data from this study can conclude that Biosilicate® was able to accelerate and optimized the bone consolidation, through the modulation of the inflammatory process and the stimulation of new bone formation. However, when resources were associated, there are no positive results.
authors.affiliation: Doctorate student on the Postgraduate course in Biotechnology, Universidade Federal de São Carlos - São Carlos, SP, Brazil.
authors.forename: Poliani de
authors.initials: Pd
authors.lastname: Oliveira
authors.affiliation: Master's degree student of the Postgraduate course in Health Sciences, Universidade Federal de São Paulo - Santos, SP, Brazil.
authors.forename: Kelly Rosseti
authors.initials: KR
authors.lastname: Fernandes
authors.affiliation: Physiotherapist, Universidade Federal de São Paulo - Santos, SP, Brazil.
authors.forename: Evandro Fornias
authors.initials: EF
authors.lastname: Sperandio
authors.affiliation: Doctorate student on the Postgraduate course in Physiological Sciences, Universidade Federal de São Carlos - São Carlos, SP, Brazil.
authors.forename: Fabio Alexandre Casarin
authors.initials: FA
authors.lastname: Pastor
authors.affiliation: Full Professor of the Universidade Federal de São Carlos - São Carlos, SP, Brazil.
authors.forename: Keico Okino
authors.initials: KO
authors.lastname: Nonaka
authors.affiliation: Full Professor of the Universidade Federal de São Carlos - São Carlos, SP, Brazil.
authors.forename: Nivaldo Antonio
authors.initials: NA
authors.lastname: Parizotto
authors.affiliation: Tenured Professor of the Universidade Federal de São Paulo - Santos, SP, Brazil.
authors.forename: Ana Claudia Muniz
authors.initials: AC
authors.lastname: Renno
keywords: Biocompatible Materials; Bone Tissue; Laser; Rats; ultrasound