title: Irreversible Blindness Following Periocular Autologous Platelet-Rich Plasma Skin Rejuvenation Treatment.
abstract: A 49-year-old woman developed acute visual loss in the right eye following bilateral cosmetic platelet-rich plasma injections to rhytids in the glabellar region. External exam showed skin necrosis in the region over the right rhytids and restricted right ocular motility. Dilated fundus exam was significant for ophthalmic artery occlusion. Imaging revealed right eye extraocular muscle ischemia and optic nerve infarction, along with right frontal, parietal, and occipital lobe infarction. Work-up for thromboembolic and vascular etiologies were negative. To our knowledge, this is the first case reported of extensive ischemia following autologous platelet-rich plasma therapy.
authors.affiliation: Department of Ophthalmology and Visual Science, Yale Eye Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
authors.forename: Krishnapriya
authors.initials: K
authors.lastname: Kalyam
authors.forename: Shaheen C
authors.initials: SC
authors.lastname: Kavoussi
authors.forename: Michael
authors.initials: M
authors.lastname: Ehrlich
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Teng
authors.forename: Nisha
authors.initials: N
authors.lastname: Chadha
authors.forename: Sarah
authors.initials: S
authors.lastname: Khodadadeh
authors.forename: Ji
authors.initials: J
authors.lastname: Liu
mesh_terms: D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000175:diagnosis; D001766:Blindness / Q000175:diagnosis / Q000209:etiology*; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007267:Injections; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009880:Ophthalmic Artery; D053657:Platelet-Rich Plasma; D015361:Rhytidoplasty / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous