title: Two new eunicellin diterpenoids from the East China Sea gorgonian Muricella sp.
abstract: A phytochemical investigation on gorgonian Muricella sp. from East China Sea resulted in the isolation of eight eunicellin diterpenoids including two new ones, muricellins A-B (1, 2). Chemical structures of these compounds were elucidated by spectroscopic techniques (1D and 2D NMR and MS) and by comparison with data reported in the literature. Anti-rheumatoid arthritis activities of 1, 3, 4, and 6 have been evaluated.
authors.affiliation: a Research Center of Basic Medical Sciences, Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics) , School of Pharmacy, Tianjin Medical University , Tianjin 300070 , China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhao
authors.affiliation: a Research Center of Basic Medical Sciences, Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics) , School of Pharmacy, Tianjin Medical University , Tianjin 300070 , China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.affiliation: b School of Pharmaceutical Science , Hainan Medical University , Haikou 571190 , China.
authors.forename: De-Jun
authors.initials: DJ
authors.lastname: Jin
authors.affiliation: a Research Center of Basic Medical Sciences, Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics) , School of Pharmacy, Tianjin Medical University , Tianjin 300070 , China.
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Duan
authors.affiliation: c Orthopeadic Research Institute of Tianjin Hospital , Tianjin Hospital , Tianjin 300211 , China.
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Xing
authors.affiliation: a Research Center of Basic Medical Sciences, Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics) , School of Pharmacy, Tianjin Medical University , Tianjin 300070 , China.
authors.forename: Sheng-An
authors.initials: SA
authors.lastname: Tang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas
chemical_list: D004224:Diterpenes; C476503:eunicellin; C000613852:muricellin A; C000613853:muricellin B
keywords: Gorgonian; Muricella sp; eunicellin diterpenoids; structural elucidation