title: Low holo-transcobalamin levels are prevalent in vegetarians and is associated with coronary artery disease in Indian population.
abstract: Coronary artery disease (CAD) has been increasing alarmingly in India. We had earlier shown that vitamin B12 deficiency is associated with CAD in Indian population. However, only about a quarter of the total vitamin B12 is internalised in the cells by the proteins transcobalamin II. Vitamin B12-bound transcobalamin II (holotranscobalamin, holoTC) is thus referred to as biologically active B12. In this study, we ascertained the levels of holoTC in 501 CAD cases and 1253 healthy controls and for the first time show that holoTC levels are significantly lower (p = 2.57E-4) in CAD (26.81 pmol/l) cases as compared to controls (29.97 pmol/l).
authors.affiliation: a Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology , Sukhdev Vihar , New Delhi , India ;|b Academy of Scientific & Innovative Research (AcSIR) , CSIR-IGIB Campus , New Delhi , India ;
authors.forename: Trayambak
authors.initials: T
authors.lastname: Basak
authors.affiliation: a Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology , Sukhdev Vihar , New Delhi , India ;
authors.forename: Gaurav
authors.initials: G
authors.lastname: Garg
authors.affiliation: a Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology , Sukhdev Vihar , New Delhi , India ;
authors.forename: Nitin
authors.initials: N
authors.lastname: Bhardwaj
authors.affiliation: a Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology , Sukhdev Vihar , New Delhi , India ;
authors.forename: Vinay Singh
authors.initials: VS
authors.lastname: Tanwar
authors.affiliation: c Department of Cardiology , All India Institute of Medical Sciences , New Delhi , India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Seth
authors.affiliation: c Department of Cardiology , All India Institute of Medical Sciences , New Delhi , India.
authors.forename: Ganesan
authors.initials: G
authors.lastname: Karthikeyan
authors.affiliation: a Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology , Sukhdev Vihar , New Delhi , India ;|b Academy of Scientific & Innovative Research (AcSIR) , CSIR-IGIB Campus , New Delhi , India ;
authors.forename: Shantanu
authors.initials: S
authors.lastname: Sengupta
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007194:India; D015995:Prevalence; D014155:Transcobalamins / Q000032:analysis*; D000066988:Vegetarians; D014805:Vitamin B 12 / Q000097:blood* / Q000502:physiology
chemical_list: D014155:Transcobalamins; D014805:Vitamin B 12
keywords: Coronary artery disease; holo-transcobalamin; vitamin B12