title: Predictive factors of iron depletion in late preterm infants at the postnatal age of 6 weeks.
abstract: Late preterm infants (born ⩾32 weeks of gestation) are at risk for developing iron deficiency and iron deficiency anaemia, and this may lead to impaired neurodevelopment. In the Netherlands, there is no guideline for standardised iron supplementation in these infants. Individualised iron supplementation has been suggested (that is, treating those infants with the highest risk), but risk factors for deprived iron stores in this specific group of infants are not well documented.
  
  
  
  In this prospective multi-centre study, we analysed the iron status at the postnatal age of 6 weeks of 68 infants born between 32 and 35 weeks of gestation in the Netherlands. Serum ferritin (SF) <70 μg/l in the absence of infection (C-reactive protein <5 mg/l) was defined as iron depletion and whenever in combination with a haemoglobin level <110 mg/dl as iron-depleted anaemia. Medical charts were reviewed to identify risk factors.
  
  
  
  Iron depletion and iron-depleted anaemia were present in 38.2% and 30.9% of the infants, respectively. Infants with a birth weight <1830 g and a SF <155 μg/l in the first week of life had a 26.4 times higher risk to develop iron depletion (95% confidence interval 3.1-227.0, P=0.003). Multivariate regression analyses also showed that iron depletion was associated with a higher number of blood draws.
  
  
  
  Iron depletion is common in late preterm infants at the age of 6 weeks in a setting without standardised iron supplementation. One should consider early individualised iron supplementation for late preterm infants with a low birth weight (<1830 g), and a low SF in the first week of life (<155 μg/l), as they have a high risk to develop iron depletion.
authors.affiliation: Department of Paediatrics, Juliana Children's Hospital/Haga Teaching Hospital, The Hague, The Netherlands.
authors.forename: M D
authors.initials: MD
authors.lastname: Akkermans
authors.affiliation: Department of Paediatrics, Juliana Children's Hospital/Haga Teaching Hospital, The Hague, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Uijterschout
authors.affiliation: Department of Paediatrics, Medical Center Alkmaar, Alkmaar, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Abbink
authors.affiliation: Department of Paediatrics, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Vos
authors.affiliation: Department of Paediatrics, Juliana Children's Hospital/Haga Teaching Hospital, The Hague, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Rövekamp-Abels
authors.affiliation: Department of Paediatrics, Medical Center Alkmaar, Alkmaar, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Boersma
authors.affiliation: Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands.|Department of Paediatrics, Emma Children's Hospital-Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: J B
authors.initials: JB
authors.lastname: van Goudoever
authors.affiliation: Department of Paediatrics, Juliana Children's Hospital/Haga Teaching Hospital, The Hague, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Brus
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000453:epidemiology; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000453:epidemiology; D000090463:Iron Deficiencies; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011446:Prospective Studies
chemical_list: D002097:C-Reactive Protein; D005293:Ferritins