title: Efficacy of a topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline(®)) against naturally acquired infections with cestodes of the genus Joyeuxiella in cats.
abstract: Cats are host to dipylidiid cestodes of the genera Diplopylidium, Dipylidium and Joyeuxiella. Broadline(®), a topical broad-spectrum combination parasiticide containing fipronil (8.3 % w/v), (S)-methoprene (10 % w/v), eprinomectin (0.4 % w/v) and the cestocide praziquantel (8.3 % w/v), has previously been shown to be efficacious against Dipylidium caninum and Diplopylidium spp. in cats. To evaluate its efficacy against Joyeuxiella species, a blinded clinical efficacy study was conducted according to GCP. All cats had evidence for naturally acquired dipylidiid cestode infection as confirmed by pre-treatment examination. Cats were allocated randomly to two groups of 13 cats each based on bodyweight: Control (untreated) and Broadline(®) at 0.12 mL/kg bodyweight administered once topically. Based on the comparison of helminth counts in the treated and untreated cats seven days post treatment, Broadline(®) demonstrated >99 % efficacy (p < 0.01) against mature J. fuhrmanni and J. pasqualei, with 11 and 13 of the untreated cats harbouring 1 to 102 or 2 to 95 cestodes, respectively. In addition, parasite counts indicated 95.9 % efficacy (p = 0.006) against the rictularoid nematode Pterygodermatites cahirensis.
authors.affiliation: Central Veterinary Research Laboratory, Dubai, United Arab Emirates.
authors.forename: Rolf K
authors.initials: RK
authors.lastname: Schuster
authors.affiliation: Veterinary Services Section, Dubai Municipality, Dubai, United Arab Emirates.
authors.forename: Murad Basheer
authors.initials: MB
authors.lastname: Mustafa
authors.affiliation: Central Veterinary Research Laboratory, Dubai, United Arab Emirates.
authors.forename: Jagadeesan Vijay
authors.initials: JV
authors.lastname: Baskar
authors.affiliation: Merial, Inc., Duluth, GA, 30096, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Rosentel
authors.affiliation: Merial, Inc., Duluth, GA, 30096, USA.
authors.forename: S Theodore
authors.initials: ST
authors.lastname: Chester
authors.affiliation: Merial GmbH, Kathrinenhof Research Center, 83101, Rohrdorf, Germany. martin.knaus@merial.com.
authors.forename: Martin
authors.initials: M
authors.lastname: Knaus
mesh_terms: D000818:Animals; D000923:Anticestodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D002589:Cestoda; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D004359:Drug Therapy, Combination; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008726:Methoprene / Q000008:administration & dosage / Q000627:therapeutic use*; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000923:Anticestodal Agents; D011720:Pyrazoles; D011223:Praziquantel; D007559:Ivermectin; C101434:eprinomectin; D008726:Methoprene; C082360:fipronil
keywords: Cat; Joyeuxiella; Praziquantel; Pterygodermatites; Topical application