title: Subclinical hypothyroidism in pregnancy: An emerging problem in Southern West Bengal: A cross-sectional study.
abstract: BACKGROUND
  Prevalence of subclinical hypothyroidism (SCH) in pregnancy varies widely in different parts of our country, but it has multiple adverse outcomes in both the mother and fetus.
  
  
  OBJECTIVE
  This study was conducted to evaluate the prevalence of SCH in pregnant women during the first trimester and to identify the prevalence of thyroid autoimmunity in pregnant women.
  
  
  METHODS
  This cross-sectional study (March 2014 to February 2015) was conducted among the pregnant women attending antenatal clinic in their first trimester at a tertiary care center. Morning samples of study participants were analyzed for free thyroxin (FT4), thyroid stimulating hormone (TSH), and thyroid peroxidase antibody (TPO Ab). Data expressed as mean ± standard deviation and percentage (%) as applicable.
  
  
  RESULTS
  Of the 510 subjects, 168 had TSH value >2.5 μIU/ml (32.94%) with normal FT4 and they were diagnosed as SCH. TSH level >4.5 μIU/ml was estimated in 13.92% (71) of the subjects. TPO Ab was positive in 57 (33.93%) of subclinical hypothyroid and 5 (1.47%) of normal subjects. 70.42% (50) of the subjects with TSH >4.5 μIU/ml had positive TPO Ab.
  
  
  CONCLUSIONS
  Prevalence of SCH is high in South Bengal and routine thyroid screening at the first antenatal visit should be done to reduce the social and financial burden caused by SCH.
authors.affiliation: Department of Gynaecology and Obstetrics, Midnapore Medical College and Hospital, Kolkata, West Bengal, India.
authors.forename: Ratan Chandra
authors.initials: RC
authors.lastname: Mandal
authors.affiliation: Department of Anaesthesiology, Midnapore Medical College and Hospital, Kolkata, West Bengal, India.
authors.forename: Debasish
authors.initials: D
authors.lastname: Bhar
authors.affiliation: Department of Anaesthesiology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.
authors.forename: Anjan
authors.initials: A
authors.lastname: Das
authors.affiliation: Department of Anaesthesiology, Midnapore Medical College and Hospital, Kolkata, West Bengal, India.
authors.forename: Sandip Roy
authors.initials: SR
authors.lastname: Basunia
authors.affiliation: Department of Anaesthesiology, IPGMER, Kolkata, West Bengal, India.
authors.forename: Sudeshna Bhar
authors.initials: SB
authors.lastname: Kundu
authors.affiliation: Department of Gynaecology and Obstetrics, Midnapore Medical College and Hospital, Kolkata, West Bengal, India.
authors.forename: Chinmay
authors.initials: C
authors.lastname: Mahapatra
keywords: Autoimmunity; first trimester; pregnancy; subclinical hypothyroidism