title: Efficacy and Safety in Retinal Vein Occlusion Treated with at Least Three Consecutive Intravitreal Dexamethasone Implants.
abstract: Purpose. To evaluate the effects of repeated intravitreal dexamethasone implant (DI) (Ozurdex®) in eyes with macular edema (ME) due to retinal vein occlusion (RVO). Methods. Multicenter observational study including patients who received more than three consecutive DI on an "as-needed" basis for the treatment of ME in RVO. Results. A total of 18 eyes were included for analysis. Mean interval of retreatment with DI was 5.1 months between the first and second DI and 5.4 months following the second DI. Baseline BCVA was 0.74 ± 0.08 log-Mar; it significantly improved to 0.45 ± 0.04 2 months after the 3rd DI. There was no significant difference between the 3 first postinjection BCVA. CMT decreased from 617 μm ± 120 μm (baseline) to 330 ± 109 μm two months after the third DI. Elevated intraocular pressure occurred in 50% and was controlled medically. Cataract progression leading to cataract surgery occurred in 69% of phakic eyes after a mean interval of 17 months. Conclusion. Repeated DI on an "as-needed" basis, with a retreatment interval <6 months, are effective in the long term in the management of ME due to RVO. Rates of increased intraocular pressure and cataract surgery seem to be higher than previously described when eyes were followed during a longer period.
authors.affiliation: Department of Ophthalmology, Claude Huriez Hospital, Michel Polonovski Street, 59037 Lille Cedex, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Proença Pina
authors.affiliation: Department of Ophthalmology, Orleans La Source Hospital, 14 rue de l'Hôpital, 45100 Orleans, France.
authors.forename: Khalil
authors.initials: K
authors.lastname: Turki
authors.affiliation: Department of Biostatistics, EA2694, CHRU Lille, University of Lille, 59000 Lille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Labreuche
authors.affiliation: Department of Biostatistics, EA2694, CHRU Lille, University of Lille, 59000 Lille, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Duhamel
authors.affiliation: Department of Ophthalmology, Saint-Vincent de Paul Hospital, Lille Catholic University, Boulevard de Belfort, BP 387, 59020 Lille Cedex, France.
authors.forename: Thi Ha Chau
authors.initials: TH
authors.lastname: Tran