title: Molecular Genetic of Atopic dermatitis: An Update.
abstract: Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The pathogenesis of AD remains unclear, but the disease results from dysfunctions of skin barrier and immune response, where both genetic and environmental factors play a key role. Recent studies demonstrate the substantial evidences that show a strong genetic association with AD. As for example, AD patients have a positive family history and have a concordance rate in twins. Moreover, several candidate genes have now been suspected that play a central role in the genetic background of AD. In last decade advanced procedures similar to genome-wide association (GWA) and single nucleotide polymorphism (SNP) have been applied on different population and now it has been clarified that AD is significantly associated with genes of innate/adaptive immune systems, human leukocyte antigens (HLA), cytokines, chemokines, drug-metabolizing genes or various other genes. In this review, we will highlight the recent advancements in the molecular genetics of AD, especially on possible functional relevance of genetic variants discovered to date.
authors.affiliation: Department of Dermatology, College of Medicine, Qassim University, Buraidah, KSA.
authors.forename: Hani A
authors.initials: HA
authors.lastname: Al-Shobaili
authors.affiliation: Research Center, College of Medicine, Qassim University, Buraidah, KSA.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Ahmed
authors.affiliation: Prince Sultan Medical and Military City, Riyadh, KSA.
authors.forename: Naief
authors.initials: N
authors.lastname: Alnomair
authors.affiliation: King Fahad Medical City, Riyadh, KSA.
authors.forename: Zeiad Abdulaziz
authors.initials: ZA
authors.lastname: Alobead
authors.affiliation: Department of Medical Biochemistry, College of Medicine, Qassim University, Buraidah, KSA.
authors.forename: Zafar
authors.initials: Z
authors.lastname: Rasheed
keywords: Atopic dermatitis; chemokine; cytokine; drug-metabolizing genes; immune genes; molecular genetics