title: The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club.
abstract: The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state of the art on the use of these biomarkers in different clinical or physiological situations like in postmenopausal women, osteoporosis in men, in elderly patients, in patients suffering from bone metastasis, in patients with chronic renal failure, in pregnant or lactating women, in intensive care patients, and in diabetics. We also gave our considerations on the analytical issues linked to the use of these biomarkers, on potential new emerging biomarkers, and on the use of bone turnover biomarkers in the follow-up of patients treated with new drugs for osteoporosis.
authors.affiliation: Department of Clinical Chemistry, UnilabLg, CIRM, University of Liège, CHU de Liège, Domaine du Sart-Tilman, 4000, Liège, Belgium. Etienne.cavalier@chu.ulg.ac.be.
authors.forename: E
authors.initials: E
authors.lastname: Cavalier
authors.affiliation: Department of Radioisotopes, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Bergmann
authors.affiliation: Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
authors.forename: O
authors.initials: O
authors.lastname: Bruyère
authors.affiliation: Department of Nephrology Dialysis Transplantation, University of Liège, CHU de Liège, Liège, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Delanaye
authors.affiliation: Pôle de Pathologie Rhumatismale, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Durnez
authors.affiliation: Pôle de Pathologie Rhumatismale, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
authors.forename: J-P
authors.initials: JP
authors.lastname: Devogelaer
authors.affiliation: Department of Bone Diseases, Hôpitaux Universitaires Genève, Geneva, Switzerland.
authors.forename: S L
authors.initials: SL
authors.lastname: Ferrari
authors.affiliation: Gerontology and Geriatrics Section, Department of Clinical and Experimental Medicine, K.U. Leuven, Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Gielen
authors.affiliation: Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Goemaere
authors.affiliation: Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium.|Centre Académique de Recherche et d'Expérimentation en Santé SPRL (CARES SPRL), Liège, Belgium.
authors.forename: J-M
authors.initials: JM
authors.lastname: Kaufman
authors.affiliation: Pôle de Pathologie Rhumatismale, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
authors.forename: A Nzeusseu
authors.initials: AN
authors.lastname: Toukap
authors.affiliation: Centre Académique de Recherche et d'Expérimentation en Santé SPRL (CARES SPRL), Liège, Belgium.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Reginster
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, CHU de Liège, Liège, Belgium.
authors.forename: A-F
authors.initials: AF
authors.lastname: Rousseau
authors.affiliation: Department of Gynaecology-Obstetrics, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Rozenberg
authors.affiliation: Division of Diabetes, Nutrition and Metabolic Disorders, University of Liège CHU de Liège, Liège, Belgium.
authors.forename: A J
authors.initials: AJ
authors.lastname: Scheen
authors.affiliation: Department of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Body
mesh_terms: D001530:Belgium; D015415:Biomarkers / Q000032:analysis*; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis*; D001859:Bone Neoplasms; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D007774:Lactation; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis*; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis; D011247:Pregnancy; D051436:Renal Insufficiency, Chronic
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Bone; Osteoporosis