title: Cerebral Hemispheric Lateralization Associated with Hippocampal Sclerosis May Affect Interictal Cardiovascular Autonomic Functions in Temporal Lobe Epilepsy.
abstract: It is well established that the temporal lobe epilepsy (TLE) is linked to the autonomic nervous system dysfunctions. Seizures alter the function of different systems such as the respiratory, cardiovascular, gastrointestinal, and urogenital systems. The aim of this work was to evaluate the possible factors which may be involved in interictal cardiovascular autonomic function in temporal lobe epilepsy with complex partial seizures, and with particular attention to hippocampal sclerosis. The study was conducted in 30 patients with intractable temporal lobe epilepsy (19 with left hippocampal sclerosis, 11 with right hippocampal sclerosis). All subjects underwent four tests of cardiac autonomic function: heart rate changes in response to deep breathing, heart rate, and blood pressure variations throughout resting activity and during hand grip, mental stress, and orthostatic tests. Our results show that the right cerebral hemisphere predominantly modulates sympathetic activity, while the left cerebral hemisphere mainly modulates parasympathetic activity, which mediated tachycardia and excessive bradycardia counterregulation, both of which might be involved as a mechanism of sudden unexpected death in epilepsy patients (SUDEP).
authors.affiliation: Physiology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V-Souissi University, 6203 Rabat, Morocco; Department of Clinical Neurophysiology, Hospital of Specialties, Ibn Sina University Hospital, Rabat Institute, 6220 Rabat, Morocco; Unit of Cardiology A, Ibn Sina University Hospital, 10000 Rabat, Morocco.
authors.forename: Rokia
authors.initials: R
authors.lastname: Ghchime
authors.affiliation: Unit of Cardiology A, Ibn Sina University Hospital, 10000 Rabat, Morocco.
authors.forename: Halima
authors.initials: H
authors.lastname: Benjelloun
authors.affiliation: Food Sciences Laboratory, Department of Biology, Faculty of Sciences Semlalia, Prince Moulay Abdellah Avenue, 40090 Marrakesh, Morocco.
authors.forename: Hajar
authors.initials: H
authors.lastname: Kiai
authors.affiliation: Department of Clinical Neurophysiology, Hospital of Specialties, Ibn Sina University Hospital, Rabat Institute, 6220 Rabat, Morocco.
authors.forename: Halima
authors.initials: H
authors.lastname: Belaidi
authors.affiliation: Department of Clinical Neurophysiology, Hospital of Specialties, Ibn Sina University Hospital, Rabat Institute, 6220 Rabat, Morocco.
authors.forename: Fatiha
authors.initials: F
authors.lastname: Lahjouji
authors.affiliation: Physiology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V-Souissi University, 6203 Rabat, Morocco; Department of Clinical Neurophysiology, Hospital of Specialties, Ibn Sina University Hospital, Rabat Institute, 6220 Rabat, Morocco.
authors.forename: Reda
authors.initials: R
authors.lastname: Ouazzani