title: The Body Mass Index, Blood Pressure, and Fasting Blood Glucose in Patients With Methamphetamine Dependence.
abstract: Methamphetamine (MA) is a prevalently abused psychostimulant in the world. Previously published studies and case reports indicated potential associations between MA and body mass index (BMI) and cardiovascular factors (eg, blood pressure and fasting blood glucose). However, these associations have not been studied clearly. This study aimed to investigate BMI and cardiovascular factors in the MA-dependent patients.A total of 1019 MA-dependent patients were recruited between February 2, 2008 and March 11, 2013. A case report was used to gather information on sociocharacteristics and drug-dependent history. Meanwhile, a number of 1019 age- and sex-matched controls' information were collected from the physical examination center. We measured BMI, blood pressure, and fasting blood glucose among the participants.MA-dependent patients had significantly lower BMI (20.4 ± 0.1 vs 23.9 ± 0.1 kg/m, P < 0.001), lower fasting blood glucose (5.0 ± 0.01 vs 5.2 ± 0.01 mmol/L, P < 0.001) and higher systolic blood pressure (122.1 ± 0.4 vs 114.8 ± 0.4 mmHg, P < 0.001) compared with the control group after adjustment of possible confounders. Additional, we only found the duration of MA use was independently associated with BMI (B = -0.08, P = 0.04).This study demonstrated that MA dependence was associated with BMI and cardiovascular factors. In addition, we found a negative association between duration of MA use and BMI.
authors.affiliation: From the Department of Neurology (DL, JZ, HS, JZ, WR, JH), Department of Clinical Laboratory (MZ), Department of Respiration (XJ), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Department of Nephrology (BH), The First Affiliated Hospital of Jiaxing University, Jiaxing, Beijing HuiLongGuan Hospital (XZ), Peking University, Beijing, China, and Menninger Department of Psychiatry and Behavioral Sciences (XZ), Baylor College of Medicine, Houston, TX.
authors.forename: Dezhao
authors.initials: D
authors.lastname: Lv
authors.forename: Meijuan
authors.initials: M
authors.lastname: Zhang
authors.forename: Xuru
authors.initials: X
authors.lastname: Jin
authors.forename: Jiyun
authors.initials: J
authors.lastname: Zhao
authors.forename: Bin
authors.initials: B
authors.lastname: Han
authors.forename: Hang
authors.initials: H
authors.lastname: Su
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhang
authors.forename: Wenwei
authors.initials: W
authors.lastname: Ren
authors.forename: Jincai
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000150:complications* / Q000175:diagnosis* / Q000534:rehabilitation; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged; D018570:Risk Assessment
chemical_list: D001786:Blood Glucose; D008694:Methamphetamine