title: [EFFECT OF NEONATAL SEIZURES ON THE SYNAPTIC PLASTICITY OF RAT SOMATOSENSORY CORTEX].
abstract: Using an experimental model of neonatal recurrent seizures we investigated the influence of epileptic seizures in the various forms of synaptic plasticity in neurons of the somatosensory cortex. We found that early seizures do not affect the post-tetanic potentiation of the amplitude of the postsynaptic potentials and the depression of postsynaptic potentials during high-frequency stimulation. However they result in the chronic increase of the long-term potentiation of synaptic transmission. These changes of synaptic plasticity may affect the processing of the sensory information in patients with a history of recurrent seizures during early development.
authors.forename: E V
authors.initials: EV
authors.lastname: Isaeva
authors.forename: O O
authors.initials: OO
authors.lastname: Lunko
authors.forename: A K
authors.initials: AK
authors.lastname: Romano
authors.forename: D S
authors.initials: DS
authors.lastname: Isaev
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003292:Convulsants / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D005481:Flurothyl / Q000494:pharmacology; D006801:Humans; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D003292:Convulsants; D005481:Flurothyl