title: Acute Pustular Dermatosis, Following Topical Treatment With Pimecrolimus, in a Child Affected With Atopic and Contact Hand Dermatitis.
abstract: Atopic dermatitis is considered an important risk factor for chronic hand dermatitis, which can be seen in children too. Pimecrolimus cream 1% is approved to treat atopic dermatitis in children aged 2 years or older. In adults, this drug has been used for some clinical indications other than atopic dermatitis, such as chronic hand dermatitis. Here, we describe an adverse drug reaction in a 2-year-old child affected with atopic dermatitis, who was treated with topical pimecrolimus in order to ameliorate her concomitant hand dermatitis. The use of topical pimecrolimus led to a previously undescribed hand pustular dermatosis, being consistent with a form of pustular leukocytoclastic vasculitis, which required the permanent discontinuation of topical pimecrolimus.
authors.affiliation: Department of Pediatrics, Azienda Ospedaliera di Melegnano, Milan, Italy.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Poddighe
authors.affiliation: Department of Dermatology, Fondazione IRCCS Policlinico San Matteo.
authors.forename: Valeria
authors.initials: V
authors.lastname: Brazzelli
authors.affiliation: Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo-Universita' degli Studi, Pavia, Italy.
authors.forename: Amelia
authors.initials: A
authors.lastname: Licari
authors.affiliation: Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo-Universita' degli Studi, Pavia, Italy.
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
keywords: Elidel cream; adverse drug effect; atopic dermatitis; pediatric; pimecrolimus; pustular dermatitis