title: Endothelial-to-hematopoietic transition: Notch-ing vessels into blood.
abstract: During development, hematopoietic stem cells (HSCs) are formed in a temporally and spatially restricted manner, arising from specialized endothelial cells (ECs) in the ventral wall of the dorsal aorta within the evolutionary conserved aorta-gonad-mesonephros region. Our understanding of the processes regulating the birth of HSCs from ECs has been recently advanced by comprehensive molecular analyses of developing murine hematopoietic cell populations complemented by studies in the zebrafish model, with the latter offering unique advantages for genetic studies and direct in vivo visualization of HSC emergence. Here, we provide a concise review of the current knowledge and recent advances regarding the cellular origin and molecular regulation of HSC development, with particular focus on the process of endothelial-to-hematopoietic transition and its primary regulator, the Notch signaling pathway.
authors.affiliation: Department of Stem Cell and Regenerative Biology, Harvard University, Boston, Massachusetts.
authors.forename: Dirk
authors.initials: D
authors.lastname: Kanz
authors.affiliation: Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
authors.forename: Martina
authors.initials: M
authors.lastname: Konantz
authors.affiliation: Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
authors.forename: Elisa
authors.initials: E
authors.lastname: Alghisi
authors.affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.|Harvard Stem Cell Institute, Cambridge, Massachusetts.
authors.forename: Trista E
authors.initials: TE
authors.lastname: North
authors.affiliation: Department of Biomedicine, University Hospital Basel, Basel, Switzerland.|Division of Hematology, University Hospital Basel, Basel, Switzerland.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lengerke
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D042783:Endothelial Cells / Q000166:cytology* / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000378:metabolism
chemical_list: D051880:Receptors, Notch; D029961:Zebrafish Proteins
keywords: GPR56; Notch; endothelial-to-hematopoietic transition; hematopoiesis; hematopoietic stem cells