title: Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study.
abstract: OBJECTIVE
  Prediabetes is associated with dysglycemia, obesity, inflammation and endothelial dysfunction, contributing towards the pathogenesis of cardiovascular diseases rendering them vulnerable for the same. The current study intended to explore the risk of cardiovascular disease (CVD) related with prediabetes by assessing oxidative stress and inflammation using serum interleukin-6 (IL-6), myeloperoxidase (MPO) and urine microalbumin (MA) and their correlation with fasting plasma glucose (FPG) and physical measurements.
  
  
  METHODS
  Based on FPG values, 80 subjects were grouped into prediabetes and healthy controls. IL-6 and MPO were estimated in serum sample whereas MA was estimated in random urine sample.
  
  
  RESULTS
  Prediabetes group had significantly increased (p<0.05) mean anthropometric measurements and IL-6, MPO and MA as compared to healthy controls. MPO had significant correlation with FPG (r-0.388) in the prediabetes group. IL-6 and MPO showed a positive correlation with body mass index (BMI (r-0.339, r-0.327)), waist circumference (WC (r-484, r-0.493)) and waist-to-hip ratio (WHR (r-0.430, r-0.493)) while MA did not correlate with FPG and anthropometric measurements.
  
  
  CONCLUSIONS
  This study suggests that prediabetes is associated with central adiposity, inflammation and oxidative stress predisposing them to an increased risk for CVD.
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, ,Mangalore 575004, Karnataka, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, ,Mangalore 575004, Karnataka, India. Electronic address: anupama.hegde@manipal.edu.
authors.forename: Anupama
authors.initials: A
authors.lastname: Hegde
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, ,Mangalore 575004, Karnataka, India.
authors.forename: Charu
authors.initials: C
authors.lastname: Yadav
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, ,Mangalore 575004, Karnataka, India.
authors.forename: Afzal
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, ,Mangalore 575004, Karnataka, India.
authors.forename: Poornima A
authors.initials: PA
authors.lastname: Manjrekar
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, ,Mangalore 575004, Karnataka, India.
authors.forename: Rukmini M
authors.initials: RM
authors.lastname: Srikantiah
mesh_terms: D000419:Albuminuria / Q000150:complications; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D006761:Hospitals; D006801:Humans; D007194:India; D015850:Interleukin-6 / Q000097:blood; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood; D011236:Prediabetic State / Q000150:complications / Q000378:metabolism*; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D015850:Interleukin-6; D009195:Peroxidase
keywords: Interleukin-6 (IL-6); Microalbuminuria (MA); Myeloperoxidase (MPO); Prediabetes