title: Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery.
abstract: Mesoporous silica material with organo-bridged silsesquioxane frameworks is a kind of synergistic combination of inorganic silica, mesopores and organics, resulting in some novel or enhanced physicochemical and biocompatible properties compared with conventional mesoporous silica materials with pure Si-O composition. With the rapid development of nanotechnology, monodispersed nanoscale periodic mesoporous organosilica nanoparticles (PMO NPs) and organo-bridged mesoporous silica nanoparticles (MSNs) with various organic groups and structures have recently been synthesized from 100%, or less, bridged organosilica precursors, respectively. Since then, these materials have been employed as carrier platforms to construct bioimaging and/or therapeutic agent delivery nanosystems for nano-biomedical application, and they demonstrate some unique and/or enhanced properties and performances. This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organo-bridged MSNs, physicochemical and biocompatible properties, and their nano-biomedical application as bioimaging agent and/or therapeutic agent delivery system.
authors.affiliation: Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing 100083, China; School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.affiliation: Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Lin
authors.initials: L
authors.lastname: Xiong
authors.affiliation: Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing 100083, China. Electronic address: zhangxueji@ustb.edu.cn.
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Quebec City, QC G1V 0A6, Canada.
authors.forename: Freddy
authors.initials: F
authors.lastname: Kleitz
authors.affiliation: School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: s.qiao@adelaide.edu.au.
authors.forename: Shi Zhang
authors.initials: SZ
authors.lastname: Qiao
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D017646:Organosilicon Compounds / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D004337:Drug Carriers; D017646:Organosilicon Compounds; D012822:Silicon Dioxide
keywords: Advanced nanocarriers; Biocompatible properties; Bioimaging; Mesoporous nanoparticles; PMOs; Therapeutic agent delivery