title: Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis.
abstract: Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under conditions of radiation-induced carcinogenesis. Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA - fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract.
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia. sergey.d.ivanov@mail.ru.
authors.forename: S D
authors.initials: SD
authors.lastname: Ivanov
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Bespalov
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Semenov
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Kovan'ko
authors.affiliation: N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Aleksandrov
mesh_terms: D000818:Animals; D018890:Chemoprevention / Q000379:methods*; D004247:DNA / Q000235:genetics; D000518:Eflornithine / Q000627:therapeutic use*; D028001:Eleutherococcus / Q000378:metabolism*; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects; D007962:Leukocytes / Q000166:cytology / Q000528:radiation effects*; D043843:Leuzea / Q000378:metabolism*; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology; D010936:Plant Extracts / Q000627:therapeutic use*; D011123:Polyploidy; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D004247:DNA; D000518:Eflornithine
keywords: chemoprophylaxis; radiation-induced carcinogenesis; rats; toxicogenomic effects