title: Autologous bone grafting with platelet-rich plasma for alveolar cleft repair in patient with cleft and palate.
abstract: OBJECTIVE
  Bone grafting of the alveolus has become an essential part of the contemporary surgical management of the oral cleft. The aim of this retrospective study was to evaluate the results of bone grafting in association with PRP (plateletrich plasma) to enhance osteogenesis and osteointegration.
  
  
  METHODS
  The study included 16 patients, aged between 9 and 11, affected with unilateral residual alveolar clefts, who underwent bone grafting using secondary alveoplasty. The eight patients belonging to the control group were administered autologous bone graft alone while the study group, consisting of 8 patients, underwent autologous bone grafting in association with PRP. All patients had pre and post surgery orthodontic treatment. The statistical analyses included Student's t test, 2 test and Kaplan-Meir time to event analysis. The p-value was considered significant if p<0.05. All statistical analyses were performed using SAS Software release 9.3 (SAS Institute, Cary, Nc).
  
  
  RESULTS
  The control group (M 50%, mean age 10.2±2.3) underwent simple autologous bone graft while the study group (M 62.5%, mean age 9.9±2.2) was treated with a combination of autologous bone and PRP. No statistically significant differences were found between the two groups as regards age, gender and labial-palatal cleft clinical characteristics. 6, 12, 24 month follow-ups were performed by means of clinical and radiographic investigations. None of the study group developed oronasal fistulas or experienced bone height, bone bridging and bone quality loss; only two patients developed mild periodontal problems. The study group was able to undergo a significantly (p<0.001) earlier and shorter orthodontic treatment.
  
  
  CONCLUSIONS
  In our experience, the use of PRP enhances the quality of osteoplasty, accelerates "creeping substitution" and bone healing and favours earlier orthodontic treatment.
  
  
  BACKGROUND
  Alveolar cleft, Bone grafting, Palate, Platelet-rich plasma.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Giudice
authors.forename: Daniela Anna
authors.initials: DA
authors.lastname: Cutrignelli
authors.forename: Sara
authors.initials: S
authors.lastname: Leuzzi
authors.forename: Fabio
authors.initials: F
authors.lastname: Robusto
authors.forename: Pasquale
authors.initials: P
authors.lastname: Sportelli
authors.forename: Eleonora
authors.initials: E
authors.lastname: Nacchiero
mesh_terms: D064728:Alveolar Bone Grafting / Q000379:methods*; D000539:Alveolar Process / Q000002:abnormalities* / Q000601:surgery; D000543:Alveoloplasty / Q000379:methods; D002648:Child; D002972:Cleft Palate / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007085:Ilium; D008297:Male; D009971:Orthodontics, Corrective; D053657:Platelet-Rich Plasma; D012189:Retrospective Studies; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome