title: Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis.
abstract: Silymarin is a naturally occurring flavonoid drug; evidence from recent research has highlighted its use as a potential treatment for atopic dermatitis (AD). Both poor water solubility and drug permeability have hindered the percutaneous absorption of silymarin. Formulation of silymarin into pluronic-lecithin organogel (PLO) basis for topical skin delivery is the main aim of this work. Six different PLO formulations were prepared containing various pluronic to lecithin ratios using two cosolvent systems of ethyl alcohol and dimethyl sulfoxide. Formulation 2 (20% pluronic and 3% lecithin) was found to be the optimal base for topical delivery of silymarin as it showed optimum pH, viscosity, drug content, and satisfactory in vitro silymarin permeation. The silymarin PLO formulation significantly relieved inflammatory symptoms of AD such as redness, swelling, and inflammation. These findings warrant the ability for application of these novel silymarin PLO formulations as a novel treatment for AD.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Medina, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
authors.forename: Fatma M
authors.initials: FM
authors.lastname: Mady
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
authors.forename: Hanaa
authors.initials: H
authors.lastname: Essa
authors.affiliation: Department of Dermatology, STDs, and Andrology, Minia University Hospital, Minia, Egypt.
authors.forename: Tarek
authors.initials: T
authors.lastname: El-Ammawi
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
authors.forename: Hamdy
authors.initials: H
authors.lastname: Abdelkader
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
authors.forename: Amal K
authors.initials: AK
authors.lastname: Hussein
mesh_terms: D000293:Adolescent; D000328:Adult; D002626:Chemistry, Pharmaceutical; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004355:Drug Stability; D005260:Female; D005782:Gels / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D054709:Lecithins / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D020442:Poloxamer / Q000737:chemistry / Q000627:therapeutic use*; D012838:Silymarin / Q000737:chemistry / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D005782:Gels; D054709:Lecithins; D012838:Silymarin; D020442:Poloxamer
keywords: atopic dermatitis; pluronic lecithin organogel; silymarin; skin penetration