title: Structure and Function of the Mitochondrial Ribosome.
abstract: Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the organelles responsible for energy conversion and adenosine triphosphate production in eukaryotic cells. Throughout evolution, mitoribosomes have become functionally specialized for synthesizing mitochondrial membrane proteins, and this has been accompanied by large changes to their structure and composition. We review recent high-resolution structural data that have provided unprecedented insight into the structure and function of mitoribosomes in mammals and fungi.
authors.affiliation: Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, CH-8093 Zurich, Switzerland; email: ban@mol.biol.ethz.ch.|*Present address: California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, California 94720-3220.
authors.forename: Basil J
authors.initials: BJ
authors.lastname: Greber
authors.affiliation: Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, CH-8093 Zurich, Switzerland; email: ban@mol.biol.ethz.ch.
authors.forename: Nenad
authors.initials: N
authors.lastname: Ban
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D005075:Biological Evolution; D002265:Carboxylic Ester Hydrolases / Q000235:genetics / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000378:metabolism; D008322:Mammals; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics* / Q000378:metabolism; D000069396:Mitochondrial Ribosomes / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure*; D008958:Models, Molecular; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism; D054657:Ribosome Subunits / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D012343:RNA, Transfer; D002265:Carboxylic Ester Hydrolases; C019674:aminoacyl-tRNA hydrolase
keywords: 28S mitoribosomal subunit; 39S mitoribosomal subunit; antibiotics; cryo-electron microscopy; mitochondrial translation; ribosome evolution