title: Nigrodiquinone A, a Hydroanthraquinone Dimer Containing a Rare C-9-C-7' Linkage from a Zoanthid-Derived Nigrospora sp. Fungus.
abstract: One new hydroanthraquinone dimer with a rare C-9-C-7' linkage, nigrodiquinone A (1), and four known anthraquinone monomers 2-5, were isolated from a fungus Nigrospora sp. obtained from the zoanthid Palythoa haddoni collected in the South China Sea. The structure of 1 was established through extensive NMR spectroscopy, and the absolute configuration was elucidated by comparing computed electronic circular dichroism (ECD) and optical rotations (OR) with experimental results. All the compounds were evaluated for antiviral activity, and 1 was also evaluated for antibacterial activity. Compound 4 displayed mild antiviral activity against coxsackie virus (Cox-B3) with the IC50 value of 93.7 μM, and 5 showed an IC50 value of 74.0 μM against respiratory syncytial virus (RSV).
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. xuweifeng_u@163.com.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Xu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. houxuemei_1990@163.com.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Hou
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. yangkailin0228@163.com.
authors.forename: Kai-Lin
authors.initials: KL
authors.lastname: Yang
authors.affiliation: College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China. caofei542927001@163.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Cao
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. yang_rui_yun@163.com.
authors.forename: Rui-Yun
authors.initials: RY
authors.lastname: Yang
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. changyun@ouc.edu.cn.|Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China. changyun@ouc.edu.cn.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. shaochanglun@163.com.|Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China. shaochanglun@163.com.
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D002681:China; D002942:Circular Dichroism; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D009792:Oceans and Seas; D009904:Optical Rotation
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents
keywords: Nigrospora sp.; antibacterial; antiviral; hydroanthraquinone dimer; zoanthid Palythoa haddoni