title: Effects of Cinnamon (C. zeylanicum) Bark Oil Against Taxanes-Induced Damages in Sperm Quality, Testicular and Epididymal Oxidant/Antioxidant Balance, Testicular Apoptosis, and Sperm DNA Integrity.
abstract: The aim of this study was to investigate whether cinnamon bark oil (CBO) has protective effect on taxanes-induced adverse changes in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm DNA integrity. For this purpose, 88 adult male rats were equally divided into 8 groups: control, CBO, docetaxel (DTX), paclitaxel (PTX), DTX+PTX, DTX+CBO, PTX+CBO, and DTX+PTX+CBO. CBO was given by gavage daily for 10 weeks at the dose of 100 mg/kg. DTX and PTX were administered by intraperitoneal injection at the doses of 5 and 4 mg/kg/week, respectively, for 10 weeks. DTX+PTX and DTX+PTX+CBO groups were treated with DTX during first 5 weeks and PTX during next 5 weeks. DTX, PTX, and their mixed administrations caused significant decreases in absolute and relative weights of all reproductive organs, testosterone level, sperm motility, concentration, glutathione level, and catalase activity in testicular and epididymal tissues. They also significantly increased abnormal sperm rate, testicular and epididymal malondialdehyde level, apoptotic germ cell number, and sperm DNA fragmentation and significantly damaged the histological structure of testes. CBO consumption by DTX-, PTX-, and DTX+PTX-treated rats provided significant ameliorations in decreased relative weights of reproductive organs, decreased testosterone, decreased sperm quality, imbalanced oxidant/antioxidant system, increased apoptotic germ cell number, rate of sperm with fragmented DNA, and severity of testicular histopathological lesions induced by taxanes. In conclusion, taxanes cause impairments in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular histopathological structure, and sperm DNA integrity, and long-term CBO consumption protects male reproductive system of rats.
authors.affiliation: a Department of Reproduction and Artificial Insemination , Faculty of Veterinary Medicine and Genome and Stem Cell Center-GENKOK, Erciyes University , Kayseri , Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Sariözkan
authors.affiliation: b Department of Reproduction and Artificial Insemination , Faculty of Veterinary Medicine, Fırat University , Elazığ , Turkey.
authors.forename: Gaffari
authors.initials: G
authors.lastname: Türk
authors.affiliation: c Department of Physiology , Faculty of Veterinary Medicine, Fırat University , Elazığ , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Güvenç
authors.affiliation: c Department of Physiology , Faculty of Veterinary Medicine, Fırat University , Elazığ , Turkey.
authors.forename: Abdurrauf
authors.initials: A
authors.lastname: Yüce
authors.affiliation: d Department of Histology and Embryology , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: Saim
authors.initials: S
authors.lastname: Özdamar
authors.affiliation: e Department of Biophysics , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: Fazile
authors.initials: F
authors.lastname: Cantürk
authors.affiliation: d Department of Histology and Embryology , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: Arzu Hanım
authors.initials: AH
authors.lastname: Yay
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D015415:Biomarkers / Q000378:metabolism; D002935:Cinnamomum zeylanicum / Q000737:chemistry; D053938:DNA Fragmentation / Q000187:drug effects; D000077143:Docetaxel; D004822:Epididymis / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009822:Oils, Volatile / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D017239:Paclitaxel / Q000009:adverse effects*; D020011:Protective Agents / Q000494:pharmacology; D017208:Rats, Wistar; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D043823:Taxoids / Q000009:adverse effects*; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009822:Oils, Volatile; D020011:Protective Agents; D043823:Taxoids; C510046:cinnamon oil, bark; D000077143:Docetaxel; D013739:Testosterone; D017239:Paclitaxel