title: Levels of uninvolved immunoglobulins predict clinical status and progression-free survival for multiple myeloma patients.
abstract: Multiple myeloma (MM) is characterized by the enhanced production of the same monoclonal immunoglobulin (M-Ig or M protein). Techniques such as serum protein electrophoresis and nephelometry are routinely used to quantify levels of this protein in the serum of MM patients. However, these methods are not without their shortcomings and problems accurately quantifying M proteins remain. Precise quantification of the types and levels of M-Ig present is critical to monitoring patient response to therapy. In this study, we investigated the ability of the HevyLite (HLC) immunoassay to correlate with clinical status based on levels of involved and uninvolved antibodies. In our cohort of MM patients, we observed that significantly higher ratios and greater differences of involved HLC levels compared to uninvolved HLC levels correlated with a worse clinical status. Similarly, higher absolute levels of involved HLC antibodies and lower levels of uninvolved HLC antibodies also correlated with a worse clinical status and a shorter progression-free survival. These findings suggest that the HLC assay is a useful and a promising tool for determining the clinical status and survival time for patients with multiple myeloma.
authors.affiliation: Institute for Myeloma & Bone Cancer Research, West Hollywood, CA, USA.
authors.forename: Nika M
authors.initials: NM
authors.lastname: Harutyunyan
authors.affiliation: Institute for Myeloma & Bone Cancer Research, West Hollywood, CA, USA.
authors.forename: Suzie
authors.initials: S
authors.lastname: Vardanyan
authors.affiliation: Institute for Myeloma & Bone Cancer Research, West Hollywood, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Ghermezi
authors.affiliation: Institute for Myeloma & Bone Cancer Research, West Hollywood, CA, USA.
authors.forename: Jillian
authors.initials: J
authors.lastname: Gottlieb
authors.affiliation: Institute for Myeloma & Bone Cancer Research, West Hollywood, CA, USA.
authors.forename: Ariana
authors.initials: A
authors.lastname: Berenson
authors.affiliation: Oncotherapeutics, West Hollywood, CA, USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Andreu-Vieyra
authors.affiliation: Institute for Myeloma & Bone Cancer Research, West Hollywood, CA, USA.|Oncotherapeutics, West Hollywood, CA, USA.|James R. Berenson, MD, Inc., West Hollywood, CA, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Berenson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods* / Q000592:standards; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007143:Immunoglobulin Heavy Chains / Q000097:blood; D007147:Immunoglobulin Light Chains / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D009194:Myeloma Proteins / Q000276:immunology*; D011379:Prognosis
chemical_list: D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins
keywords: HevyLite; immunoglobulins; multiple myeloma; outcomes