title: Maternal and infant outcomes among women vaccinated against pertussis during pregnancy.
abstract: Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination is recommended for all women during each pregnancy to prevent pertussis in young infants. However, data on the safety of this protective measure are limited and conflicting. To assess maternal and infant outcomes associated with administration of this vaccine during pregnancy, we reviewed medical records of 1,759 women who delivered a singleton infant at a southeast Texas public hospital between November 1, 2012 and June 30, 2014. After excluding women who had inadequate prenatal care or who delivered at <27 weeks gestation, we used multivariable logistic regression analyses to compare 13 outcomes between those who did and did not receive the Tdap vaccine. We examined 6 maternal outcomes (chorioamnionitis, postpartum endometritis, preterm delivery, preterm premature rupture of membranes, induced labor, and mode of delivery) and 7 infant outcomes (low birth weight, very low birth weight, small for gestational age, 5-minute Apgar score, birth defects, and neonatal intensive care unit admission). Maternal Tdap vaccination was associated with decreased odds of cesarean delivery. No associations between maternal Tdap vaccination and infant outcomes were observed. This study demonstrates that Tdap vaccination during pregnancy does not increase the risk of adverse outcomes.
authors.affiliation: a Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch , Galveston , TX , USA.|b Department of Obstetrics & Gynecology, University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Abbey B
authors.initials: AB
authors.lastname: Berenson
authors.affiliation: a Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch , Galveston , TX , USA.|b Department of Obstetrics & Gynecology, University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Hirth
authors.affiliation: a Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch , Galveston , TX , USA.|b Department of Obstetrics & Gynecology, University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Mahbubur
authors.initials: M
authors.lastname: Rahman
authors.affiliation: a Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Tabassum H
authors.initials: TH
authors.lastname: Laz
authors.affiliation: a Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch , Galveston , TX , USA.|c Department of Pediatrics, University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Rupp
authors.affiliation: a Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch , Galveston , TX , USA.|c Department of Pediatrics, University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Kwabena O
authors.initials: KO
authors.lastname: Sarpong
mesh_terms: D000328:Adult; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control*; D012189:Retrospective Studies; D013781:Texas; D016896:Treatment Outcome; D014917:Whooping Cough / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines
keywords: Tdap; infant outcomes; maternal outcomes; pertussis; pregnancy; vaccination; vaccine safety