title: Cohort Profile: The Saguenay Youth Study (SYS).
abstract: The Saguenay Youth Study (SYS) is a two-generational study of adolescents and their parents (n = 1029 adolescents and 962 parents) aimed at investigating the aetiology, early stages and trans-generational trajectories of common cardiometabolic and brain diseases. The ultimate goal of this study is to identify effective means for increasing healthy life expectancy. The cohort was recruited from the genetic founder population of the Saguenay Lac St Jean region of Quebec, Canada. The participants underwent extensive (15-h) phenotyping, including an hour-long recording of beat-by-beat blood pressure, magnetic resonance imaging of the brain and abdomen, and serum lipidomic profiling with LC-ESI-MS. All participants have been genome-wide genotyped (with ∼ 8 M imputed single nucleotide polymorphisms) and a subset of them (144 adolescents and their 288 parents) has been genome-wide epityped (whole blood DNA, Infinium HumanMethylation450K BeadChip). These assessments are complemented by a detailed evaluation of each participant in a number of domains, including cognition, mental health and substance use, diet, physical activity and sleep, and family environment. The data collection took place during 2003-12 in adolescents (full) and their parents (partial), and during 2012-15 in parents (full). All data are available upon request.
authors.affiliation: Hospital for Sick Children and Departments of Physiology and Nutritional Science.
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Pausova
authors.affiliation: Rotman Research Institute and Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada.|Child Mind Institute, New York, NY, USA.
authors.forename: Tomas
authors.initials: T
authors.lastname: Paus
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
authors.forename: Michal
authors.initials: M
authors.lastname: Abrahamowicz
authors.affiliation: Hospital for Sick Children and Departments of Physiology and Nutritional Science.
authors.forename: Manon
authors.initials: M
authors.lastname: Bernard
authors.affiliation: Community Genomic Centre, Université de Montréal, Chicoutimi, QC, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gaudet
authors.affiliation: Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Leonard
authors.affiliation: Department of Human Sciences, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Peron
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Calgary, BC, Canada.
authors.forename: G Bruce
authors.initials: GB
authors.lastname: Pike
authors.affiliation: Department of Health Sciences, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada and.
authors.forename: Louis
authors.initials: L
authors.lastname: Richer
authors.affiliation: Sainte-Justine Hospital Research Center and Department of Psychiatry, Université de Montréal, Montreal, QC, Canada.
authors.forename: Jean R
authors.initials: JR
authors.lastname: Séguin
authors.affiliation: Department of Human Sciences, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Veillette
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D001921:Brain / Q000000981:diagnostic imaging*; D003071:Cognition; D015331:Cohort Studies; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008055:Lipids / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010290:Parents; D011792:Quebec / Q000453:epidemiology; D019966:Substance-Related Disorders
chemical_list: D008055:Lipids