title: Research on genesis of adipocytic metaplasia in uterine fibroids.
abstract: The genesis of lipoleiomyoma has not been explained yet. Immunohistochemical examinations were performed on 17 lipoleiomyomas in women aged 43-82 (mean age: 51 ±9 years). Four types of myomas were distinguished: 1) pure leiomyoma, 2) fibroleiomyoma, 3) hyalinizing leiomyoma, 4) strongly hyalinized myoma, along with three degrees of progression of adipocytic metaplasia: 1) up to 25% of lipocytes, 2) up to 50% of lipocytes, and 3) over 50% of lipocytes in the analyzed sample, along with three degrees of progression of adipocytic metaplasia: 1) up to 25% of lipocytes, 2) up to 50% of lipocytes, and 3) over 50% of lipocytes in the analyzed sample. A positive correlation was found between the age of women and rate of development of metaplasia (r = 0.51, p = 0.035) as well as with activity of the estrogen receptor in the primary tumor (r = 0.53, p = 0.03). New mucous perivascular tissue was reported among 11.8% of patients and on this basis lipocytes were formed. The appearance of subendothelial granular cells of large blood vessels with a positive reaction for smooth muscle actin (SMA) and CD68 was reported in 17.7%. Results of immunohistochemical research seem to confirm that lipocytes de novo come from the primal pluripotent cells of the tumor stroma and not from the fatty degeneration of myocytes.
authors.forename: Henryk
authors.initials: H
authors.lastname: Sośnik
authors.affiliation: Prof. Michał Jeleń, Department of Pathomorphology, and Oncological Cytology, Borowska 213, 51-213 Wrocław, tel. +48 71 734 39 60, e-mail: michal.jelen@umed.wroc.pl.
authors.forename: Michał
authors.initials: M
authors.lastname: Jeleń
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kosiński
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sośnik
mesh_terms: D017667:Adipocytes; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism / Q000473:pathology*; D008679:Metaplasia; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*; D014599:Uterus / Q000473:pathology*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone