title: Opsoclonus-Myoclonus Syndrome in Primary Central Nervous System Lymphoma.
abstract: Adult-onset opsoclonus-myoclonus syndrome (OMS) has been associated with multiple cancers, most commonly small-cell lung carcinoma and breast adenocarcinoma. A 53-year-old woman who presented with OMS was found to have primary central nervous system (CNS) diffuse large B-cell lymphoma. OMS has been described in only 5 cases with non-Hodgkin lymphoma (NHL), and this is only the third reported case of OMS in NHL limited to the CNS. Although the paraneoplastic antibody panel was negative, we presume that the OMS was a paraneoplastic manifestation. Antineoplastic and anti-immune therapy had no effect on the neurologic manifestations.
authors.affiliation: Departments of Ophthalmology and Visual Sciences (JG, JDT), Neurology (JDT) and Pathology (Neuropathology) (AFH), Kellogg Eye Center, University of Michigan Medical System, Ann Arbor, Michigan.
authors.forename: Joseph
authors.initials: J
authors.lastname: Grubbs
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Trobe
authors.forename: Amanda
authors.initials: A
authors.lastname: Fisher-Hubbard
mesh_terms: D001706:Biopsy; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D053578:Opsoclonus-Myoclonus Syndrome / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed