title: Association of apelin, endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients.
abstract: OBJECTIVE
  Diabetic peripheral neuropathy is a common complication of type-2 diabetes mellitus. Endocan, apelin and endoglin are thought to be associated with endothelial dysfunction, angiogenesis and inflammation. In this study, we planned to evaluate these markers in diabetic peripheral neuropathy patients.
  
  
  METHODS
  This single-blind, controlled clinical study was conducted on 99 type 2 diabetic patients with or without diabetic peripheral neuropathy and 53 healthy volunteer controls. Physical and laboratory examinations were done in all groups. In these groups, Endoglin, apelin and endocan levels were measured with ELISA method.
  
  
  RESULTS
  Endoglin, apelin and endocan concentrations in diabetic peripheral neuropathy patients were higher than other diabetes mellitus patients and healthy controls. Similarly, diabetes mellitus patient's endoglin, apelin and endocan levels were higher than healthy controls. The differences were statistically significant. We detected a significant positive correlation between endoglin, apelin and endocan levels in all groups.
  
  
  CONCLUSIONS
  Endoglin, apelin and endocan may reflect angiogenesis and endothelial dysfunction in diabetic peripheral neuropathy and they may be used as a marker in the future.
authors.affiliation: Department of Internal Medicine, Namik Kemal University School of Medicine, Tekirdag, Turkey. bulentbilir@yahoo.com.
authors.forename: B
authors.initials: B
authors.lastname: Bilir
authors.forename: B
authors.initials: B
authors.lastname: Ekiz Bilir
authors.forename: I
authors.initials: I
authors.lastname: Yilmaz
authors.forename: N
authors.initials: N
authors.lastname: Soysal Atile
authors.forename: T
authors.initials: T
authors.lastname: Yildirim
authors.forename: S P
authors.initials: SP
authors.lastname: Kara
authors.forename: S A
authors.initials: SA
authors.lastname: Gumustas
authors.forename: A E
authors.initials: AE
authors.lastname: Orhan
authors.forename: M
authors.initials: M
authors.lastname: Aydin
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D000073861:Apelin; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D003929:Diabetic Neuropathies / Q000097:blood / Q000175:diagnosis*; D000071063:Endoglin; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011509:Proteoglycans / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood*; D016037:Single-Blind Method
chemical_list: C115436:APLN protein, human; D015703:Antigens, CD; D000073861:Apelin; D015415:Biomarkers; C064206:ENG protein, human; C101134:ESM1 protein, human; D000071063:Endoglin; D036341:Intercellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D011509:Proteoglycans; D011956:Receptors, Cell Surface