title: Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity.
abstract: In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for α-glucosidase inhibitory activity by the MTT method, with the IC50 values being 25.3 ± 1.6 and 28.5 ± 3.3 μmol·L(-1), respectively.
authors.affiliation: Department of Traditional Chinese Medicinal Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors.forename: Jie-Hong
authors.initials: JH
authors.lastname: Li
authors.affiliation: Department of Traditional Chinese Medicinal Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors.forename: Jie-Tao
authors.initials: JT
authors.lastname: Pan
authors.affiliation: Department of Traditional Chinese Medicinal Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: yongqinyin@126.com.
authors.forename: Yong-Qin
authors.initials: YQ
authors.lastname: Yin
mesh_terms: D065089:Glycoside Hydrolase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D027741:Ipomoea / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology*; D012116:Resins, Plant / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D000520:alpha-Glucosidases
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D012116:Resins, Plant; D000520:alpha-Glucosidases
keywords: Ipomoea cairica; Resin glycoside; Simonic acid A; α-Glucosidase