title: Aging, inflammation, stem cells, and bone healing.
abstract: Complex interactions among cells of the monocyte-macrophage-osteoclast lineage and the mesenchymal stem cell-osteoblast lineage play a major role in the pathophysiology of bone healing. Whereas the former lineage directs inflammatory events and bone resorption, the latter represents a source of cells for bone regeneration and immune modulation. Both of these lineages are affected by increasing age, which is associated with higher baseline levels of inflammatory mediators, and a significant reduction in osteogenic capabilities. Given the above, fracture healing, osteoporosis, and other related events in the elderly present numerous challenges, which potentially could be aided by new therapeutic approaches to modulate both inflammation and bone regeneration.
authors.affiliation: Department of Orthopaedic Surgery, Stanford University, R116, 300 Pasteur Drive, Stanford, CA, 94305, USA.|Laboratoire de Biomécanique et Biomatériaux Ostéo-Articulaires - UMR CNRS 7052, Faculté de Médecine - Université Paris7, 10 avenue de Verdun, 75010, Paris, France.|Department of Orthopaedic Surgery, Hopital Cochin, APHP, Université Paris5, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gibon
authors.affiliation: Department of Orthopaedic Surgery, Stanford University, R116, 300 Pasteur Drive, Stanford, CA, 94305, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Orthopaedic Surgery, Stanford University, R116, 300 Pasteur Drive, Stanford, CA, 94305, USA. goodbone@stanford.edu.
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Goodman
mesh_terms: D000375:Aging; D000818:Animals; D001861:Bone Regeneration; D002454:Cell Differentiation; D017102:Fracture Healing / Q000276:immunology*; D050723:Fractures, Bone / Q000276:immunology*; D006801:Humans; D007249:Inflammation; D008264:Macrophages / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000502:physiology; D010012:Osteogenesis; D013234:Stem Cells / Q000502:physiology*