title: Primary surgery for advanced-stage laryngeal cancer: A stage and subsite-specific survival analysis.
abstract: Treatment recommendations for advanced-stage laryngeal squamous cell carcinoma (SCC) have evolved significantly over the last 2 decades.
  
  
  
  We retrospectively analyzed patients in the Surveillance, Epidemiology, and End Results (SEER) database with advanced-stage laryngeal SCC treated between 2004 and 2012.
  
  
  
  A total of 6797 patients were identified in the SEER database who met inclusion criteria, with 2051 patients undergoing primary surgery and 4746 patients undergoing primary radiotherapy (RT) or chemoradiotherapy (CRT). Disease-specific survival (DSS) and overall survival (OS) were significantly better for patients treated with primary surgery when compared using Kaplan-Meier curves and a Cox multivariate regression. When survival analysis was repeated for patients stratified by T classification, N classification, and subsite, OS and DSS benefits from primary surgery were observed for patients with T3 and T4a tumors, N0 neck disease, or supraglottic primaries.
  
  
  
  Patients with advanced-stage laryngeal SCC with T3 and T4a tumors, N0 neck disease, or supraglottic primaries have the greatest chance of survival when treated with primary surgery. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1380-1386, 2016.
authors.affiliation: Department of Otolaryngology, Division of Head and Neck Surgery, University of California Davis, Sacramento, California.
authors.forename: Brianna N
authors.initials: BN
authors.lastname: Harris
authors.affiliation: Department of Otolaryngology, Division of Head and Neck Surgery, University of California Davis, Sacramento, California.
authors.forename: Aditi A
authors.initials: AA
authors.lastname: Bhuskute
authors.affiliation: Department of Oncology, Division of Head and Neck Surgery, University of California Davis, Sacramento, California.
authors.forename: Shyam
authors.initials: S
authors.lastname: Rao
authors.affiliation: Department of Otolaryngology, Division of Head and Neck Surgery, University of California Davis, Sacramento, California.
authors.forename: D Gregory
authors.initials: DG
authors.lastname: Farwell
authors.affiliation: Department of Otolaryngology, Division of Head and Neck Surgery, University of California Davis, Sacramento, California.
authors.forename: Arnaud F
authors.initials: AF
authors.lastname: Bewley
mesh_terms: D000367:Age Factors; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D059248:Chemoradiotherapy / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D018570:Risk Assessment; D018426:SEER Program; D012737:Sex Factors; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D014481:United States
keywords: chemoradiotherapy; head and neck cancer; laryngeal cancer; surgery; survival