title: CYP gene expressions in obesity-associated metabolic syndrome.
abstract: The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study.
  
  
  
  A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system.
  
  
  
  We observed marked suppressions in CYP2A6 (p=0.0123), CYP4F2 (p=0.0005), CYP3A5 (p=0.0003), and CYP17A1 (p<0.0001) gene expressions in MetS patients.
  
  
  
  This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. Electronic address: suzan2471@yahoo.com.tr.
authors.forename: Suzan
authors.initials: S
authors.lastname: Tabur
authors.affiliation: Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Oztuzcu
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Oguz
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Seniz
authors.initials: S
authors.lastname: Demiryürek
authors.affiliation: Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Dagli
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Alasehirli
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Ozkaya
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Abdullah T
authors.initials: AT
authors.lastname: Demiryürek
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D065637:Cytochrome P-450 CYP2A6 / Q000235:genetics / Q000378:metabolism*; D051544:Cytochrome P-450 CYP3A / Q000235:genetics / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D000072470:Cytochrome P450 Family 4 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D003577:Cytochrome P-450 Enzyme System; C585710:CYP2A6 protein, human; C510164:CYP3A5 protein, human; D065637:Cytochrome P-450 CYP2A6; D051544:Cytochrome P-450 CYP3A; D000072470:Cytochrome P450 Family 4; C501892:CYP17A1 protein, human; D013254:Steroid 17-alpha-Hydroxylase
keywords: Cytochrome P450; Gene expression; Metabolic syndrome; Obesity; Polymerase chain reaction