title: Human papillomavirus integration pattern and demographic, clinical, and survival characteristics of patients with oropharyngeal squamous cell carcinoma.
abstract: In human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC), reported rates of HPV integration into the host genome vary. Among patients with oropharyngeal SCC, we determined differences in demographic, clinical, and survival characteristics between those with integrated and episomal HPV.
  
  
  
  The analysis included patients with newly diagnosed oropharyngeal SCC presenting to one institution during 1996 to 2011. HPV-positive samples were classified according to HPV physical state as integrated, episomal, or mixed. Overall, progression-free, and disease-specific survival, distant metastasis rate, and second primary malignancy rate were calculated.
  
  
  
  Among 307 patients, 179 had HPV-positive tumors. Of these, 22 (12%) had episomal, 42 (24%) had integrated, and 115 (64%) had mixed HPV. Among the 3 subgroups, there were no significant differences in demographic, clinical, or survival characteristics.
  
  
  
  The majority of HPV-positive oropharyngeal SCCs have either integrated or both episomal and integrated HPV with no significant differences in survival among the groups. © 2016 Wiley Periodicals, Inc. Head Neck 38:1139-1144, 2016.
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.|Department of Otolaryngology, Tan Tock Seng Hospital, Singapore.
authors.forename: Ming Yann
authors.initials: MY
authors.lastname: Lim
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Kristina R
authors.initials: KR
authors.lastname: Dahlstrom
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.|Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Erich M
authors.initials: EM
authors.lastname: Sturgis
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.|Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Guojun
authors.initials: G
authors.lastname: Li
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D002173:Cancer Care Facilities; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology* / Q000628:therapy / Q000821:virology; D015331:Cohort Studies; D003131:Combined Modality Therapy; D004279:DNA, Viral / Q000032:analysis; D018572:Disease-Free Survival; D005260:Female; D016678:Genome; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D011379:Prognosis; D012016:Reference Values; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D013781:Texas
chemical_list: D004279:DNA, Viral
keywords: episomal; human papillomavirus; integration; oropharyngeal cancer; viral physical state