title: [Expression and clinical significance of kisspeptin-1, matrix metalloproteinase-2 and vascular endothelial growth factor in tissue of colon cancer].
abstract: OBJECTIVE
  To detect the expression of kisspeptin-1 (KISS-1), matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in the tissue of colon cancer, and analyze the relativity between KISS-1, MMP-2, VEGF and pathological characteristics of colon cancer.
  
  
  METHODS
  A total of 60 colon cancer patients and 60 patients with benign colorectal disease who received surgical treatment in our hospital from January 2009 to June 2010 were selected as observation group and control group respectively. The cancer tissue samples and excision samples collected from them were used to detect KISS-1, MMP-2 and VEGF with immunohistochemistry.
  
  
  RESULTS
  The positive rates of KISS-1, MMP-2 and VEGF were 31.7%, 58.3% and 78.3% in observation group, and 73.3%, 16.7% and 33.3% in control group. The positive rate of KISS-1 in observation group was lower than that in control group (χ(2)=23.489, P<0.001), and the positive rates of MMP-2 and VEGF in observation group were higher than those in control group (χ(2)=27.469, P<0.001; χ(2)=25.817, P<0.001). The expressions of KISS-1, MMP-2 and VEGF were significantly related with the histological grade and TNM stage of colon cancer (χ(2)=8.997, P=0.011; χ(2)=6.163, P=0.013; χ(2)=8.519, P=0.014; χ(2)=9.160, P=0.002; χ(2)=16.577, P<0.001; χ(2)=10.523, P=0.001).
  
  
  CONCLUSIONS
  It is helpful to understand the differentiation and clinical stage of colon cancer and provide evidence for clinical diagnosis and prognosis prediction by detecting KISS-1, MMP-2 and VEGF.
authors.affiliation: Department of Oncology, Weifang People's Hospital of Shandong Province, Weifang 261042, China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Wang
authors.forename: Yuanling
authors.initials: Y
authors.lastname: Qi
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Haipeng
authors.initials: H
authors.lastname: Ren
mesh_terms: D003110:Colonic Neoplasms / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D059648:Kisspeptins / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D059648:Kisspeptins; D042461:Vascular Endothelial Growth Factor A; D020778:Matrix Metalloproteinase 2