title: Highly Diastereoselective Route to α-Glucosidase Inhibitors, Neosalacinol and Neoponkoranol.
abstract: A facile and highly diastereoselective route to potent natural α-glucosidase inhibitors, i.e., neosalacinol (4) and neoponkoranol (6), isolated from the traditional Ayurvedic medicine "Salacia" was developed by intramolecular cyclization of appropriately substituted sulfides (9 and 12).
authors.forename: Genzoh
authors.initials: G
authors.lastname: Tanabe
authors.forename: Youya
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Misato
authors.initials: M
authors.lastname: Oka
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Kunikata
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tsutsui
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.
authors.forename: Weija
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Organic Chemistry, Telangana University , Nizamabad 503322, Telangana State, India.
authors.forename: Gorre
authors.initials: G
authors.lastname: Balakishan
authors.affiliation: Faculty of Pharmacy, Applied Science Private University , Al Arab St 21, Amman 11931, Jordan.
authors.forename: Mumen F A
authors.initials: MF
authors.lastname: Amer
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Marumoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
mesh_terms: D003500:Cyclization; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D049918:Salacia / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013402:Sugar Alcohols / Q000737:chemistry* / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry* / Q000494:pharmacology*; D013440:Sulfides / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C559081:1,4-dideoxy-1,4-((2,3,4,5,6-pentahydroxyhexyl)episulfoniumylidene)arabinitol; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D013402:Sugar Alcohols; D013431:Sulfates; D013440:Sulfides; D013876:Thiophenes; C427963:salacinol