title: Update on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinib.
abstract: Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia chromosome and the bcr-abl gene. The discovery of tyrosine kinase inhibitors (TKIs) revolutionized therapy for CML, such that durable response, increased overall survival, and increased progression-free survival of patients in chronic phase CML is now possible. Due to resistance and intolerance to imatinib, there was need for development of second- and third-generation TKIs for the treatment of CML. This review examines the role of nilotinib, an oral second-generation TKI, in the treatment of Philadelphia positive CML. The pharmacology, efficacy, and safety of nilotinib are critically evaluated. Patient-related issues, including tolerance, drug interactions, and quality of life issues are also examined.
authors.affiliation: Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Josephine
authors.initials: J
authors.lastname: Emole
authors.affiliation: Moffitt Program for Outreach Wellness Education and Resources, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Taiwo
authors.initials: T
authors.lastname: Talabi
authors.affiliation: Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Pinilla-Ibarz
keywords: chronic myelogenous leukemia; nilotinib; tyrosine kinase inhibitor