title: No correlation between statin exposure and incident diabetes mellitus in HIV-1-infected patients receiving combination antiretroviral therapy.
abstract: Recent clinical studies and one meta-analysis have shown a modest but significant increase in the incidence of diabetes mellitus associated with statin exposure, so this correlation was investigated in a cohort of HIV-positive subjects.
  
  
  
  A retrospective cohort study including adult HIV-1-infected patients followed at our Clinic of Infectious Diseases between 2007 and 2014 was performed.
  
  
  
  We assessed 3170 HIV-positive patients with a median follow-up of 5.2 years. The incidence of diabetes mellitus was 1.2 per 100 person-years and it was not significantly associated with the prescription of statins [hazard ratio (HR) 1.09 per year of statin exposure; 95% confidence interval (CI) 0.7-1.49; P = 0.067], while it was associated with older age, chronic hepatitis C, antiretroviral-naïve vs. antiretroviral experienced condition, high body mass index, and high serum concentration of triglycerides.
  
  
  
  In our study, a higher risk of diabetes mellitus was not associated with statin treatment, but with some traditional risk factors.
authors.affiliation: Department of Medical and Surgical Sciences, Section of Infectious Diseases, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.|Department of Specialized, Diagnostic and Experimental Medicine, Section of Microbiology, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Calza
authors.affiliation: Department of Medical and Surgical Sciences, Section of Infectious Diseases, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Colangeli
authors.affiliation: Department of Medical and Surgical Sciences, Section of Infectious Diseases, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Magistrelli
authors.affiliation: Department of Medical and Surgical Sciences, Section of Infectious Diseases, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Manfredi
authors.affiliation: Department of Specialized, Diagnostic and Experimental Medicine, Section of Microbiology, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Bon
authors.affiliation: Department of Specialized, Diagnostic and Experimental Medicine, Section of Microbiology, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Re
authors.affiliation: Department of Medical and Surgical Sciences, Section of Infectious Diseases, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Viale
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D000924:Anticholesteremic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D044966:Anti-Retroviral Agents; D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: HIV infection; cardiovascular disease; diabetes mellitus; glucose; statin