title: Extracellular α-synuclein--a possible initiator of inflammation in Parkinson's disease.
abstract: Parkinson's disease (PD) is a progressive neurodegenerative disease involving the loss of dopamine-producing neurons of the substantia nigra and the presence of Lewy bodies which contain high levels of α-synuclein. Although the causative factors of PD remain unclear, the progression of PD is accompanied by a highly localized inflammatory response mediated by reactive microglia. Recently, attention has focused on the relationship between α-synuclein and microglial activation. This review examines the role of α-synuclein on microglia in PD pathogenesis and progression, we also discuss the way of α-synuclein induced microglial activation.
authors.forename: Wen-qing
authors.initials: WQ
authors.lastname: Ren
authors.forename: Zeng-min
authors.initials: ZM
authors.lastname: Tian
authors.forename: Feng
authors.initials: F
authors.lastname: Yin
authors.forename: Jun-zhao
authors.initials: JZ
authors.lastname: Sun
authors.forename: Jian-ning
authors.initials: JN
authors.lastname: Zhang
mesh_terms: D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology*; D008262:Macrophage Activation; D017628:Microglia / Q000473:pathology; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology*; D051844:alpha-Synuclein / Q000235:genetics* / Q000378:metabolism
chemical_list: C497604:SNCA protein, human; D051844:alpha-Synuclein