title: Rotavirus replication and the role of cellular lipid droplets: New therapeutic targets?
abstract: Rotaviruses (RVs) are a major cause of acute gastroenteritis in infants and young children worldwide. These viruses infect the villous epithelium of the small intestine. Part of their replication occurs in cytoplasmic inclusion bodies termed viroplasms. Viroplasms and the lipid droplets (LDs) of cellular organelles are known to interact both physically and functionally. Compounds interfering with the homoeostasis of LDs significantly decrease the production of infectious RV progeny. There is considerable scope for more detailed exploration of such compounds as potential antiviral agents for a disease for which at present no specific therapy exists.
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address: amll1@medschl.cam.ac.uk.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lever
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Desselberger
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002648:Child; D005759:Gastroenteritis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000378:metabolism*; D007223:Infant; D007545:Isoproterenol / Q000494:pharmacology; D066292:Lipid Droplets / Q000378:metabolism* / Q000821:virology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D012401:Rotavirus / Q000145:classification / Q000502:physiology*; D012400:Rotavirus Infections / Q000188:drug therapy*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000318:Adrenergic beta-Agonists; D000998:Antiviral Agents; D010726:Phosphodiesterase Inhibitors; D007545:Isoproterenol
keywords: antiviral activity; lipid droplets; lipid metabolism inhibitors; rotavirus