title: Soft Tissue Regeneration under the Effect of Wound Coating Based on Chitosan (Natural Biopolymer).
abstract: We developed wound coating based on natural biopolymer chitosan with additional components (ceruloplasmin, L-asparaginic acid, and glycerol). Experiments on albino male rats demonstrated its regeneratory, antioxidant, and antibacterial effects on wounds involving all layers of the skin. Due to chemical composition and buffer component, the biodegraded wound coating optimizes all phases of the wound process, accelerates by 22-28% the reparative regeneration, and leads to anatomic and functional restoration of injured sites. High absorption capacity recommends its use in the treatment of wounds with profuse exudation.
authors.affiliation: Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia. gladckowa.katya@yandex.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Gladkova
authors.affiliation: Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Babushkina
authors.affiliation: Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Norkin
authors.affiliation: Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Mamonova
authors.affiliation: Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia.
authors.forename: D M
authors.initials: DM
authors.lastname: Puchin'yan
authors.affiliation: Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Konyuchenko
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002570:Ceruloplasmin / Q000627:therapeutic use; D048271:Chitosan / Q000627:therapeutic use*; D005990:Glycerol / Q000627:therapeutic use; D048091:Guided Tissue Regeneration / Q000379:methods*; D008297:Male; D051381:Rats; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D048271:Chitosan; D002570:Ceruloplasmin; D005990:Glycerol
keywords: chitosan; rats; reparation; skin; wound healing