title: Monocyte subsets and monocyte-platelet aggregates: implications in predicting septic mortality among surgical critical illness patients.
abstract: BACKGROUND
  Monocyte subsets and monocyte-platelet aggregates (MPAs) play important roles in inflammation.
  
  
  OBJECTIVE
  To evaluate the association between the three human monocyte subsets and their contributions to MPAs and mortality among septic patients.
  
  
  METHODS
  Consecutive septic patients were enrolled in. Age- and gender-matched nonseptic patients were recruited as control patients. Monocyte subsets and monocyte-platelet aggregates were determined by flow cytometric analysis.
  
  
  RESULTS
  Elevated percentage of MPAs (MPAs%) was associated with an increased risk of mortality.
  
  
  CONCLUSIONS
  This study demonstrated increased MPAs% enables the identification of a group of septic patients at high risk of death.
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wu
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Ren
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Hu
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Xiuwen
authors.initials: X
authors.lastname: Wu
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Guanwei
authors.initials: G
authors.lastname: Li
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Gefei
authors.initials: G
authors.lastname: Wang
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Gu
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Ranran
authors.initials: R
authors.lastname: Li
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Hong
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Huajian
authors.initials: H
authors.lastname: Ren
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Yunzhao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002449:Cell Aggregation; D016638:Critical Illness; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000401:mortality
keywords: Monocyte subset; monocyte–platelet aggregates; mortality; sepsis