title: Stereoarrayed CF3 -Substituted 1,3-Diols by Dynamic Kinetic Resolution: Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation.
abstract: CF3 -substituted 1,3-diols were stereoselectively prepared in excellent enantiopurity and high yield from CF3 -substituted diketones by using an ansa-ruthenium(II)-catalyzed asymmetric transfer hydrogenation in formic acid/triethylamine. The intermediate mono-reduced alcohol was also obtained in very high enantiopurity by applying milder reaction conditions. In particular, CF3 C(O)-substituted benzofused cyclic ketones underwent either a single or a double dynamic kinetic resolution during their reduction.
authors.affiliation: National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia.|Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia.
authors.forename: Andrej Emanuel
authors.initials: AE
authors.lastname: Cotman
authors.affiliation: UMR CNRS 6014 C.O.B.R.A., Université et INSA de Rouen, 1 rue Tesnière, 76821, Mont Saint Aignan, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Cahard
authors.affiliation: National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia. barbara.mohar@ki.si.
authors.forename: Barbara
authors.identifier: http://orcid.org/0000-0001-5393-7030
authors.initials: B
authors.lastname: Mohar
keywords: alcohols; asymmetric catalysis; enantioselectivity; kinetic resolution; ruthenium