title: Neurotrophic factors in Parkinson's disease are regulated by exercise: Evidence-based practice.
abstract: We carried out a qualitative review of the literature on the influence of forced or voluntary exercise in Parkinson's Disease (PD)-induced animals, to better understand neural mechanisms and the role of neurotrophic factors (NFs) involved in the improvement of motor behavior. A few studies indicated that forced or voluntary exercise may promote neuroprotection, through upregulation of NF expression, against toxicity of drugs that simulate PD. Forced training, such as treadmill exercise and forced-limb use, adopted in most studies, in addition to voluntary exercise on a running wheel are suitable methods for NFs upregulation.
authors.affiliation: Laboratório de Neurobiologia Comparativa e do Desenvolvimento, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: Paula Grazielle Chaves
authors.initials: PG
authors.lastname: da Silva
authors.affiliation: Laboratório de Neurobiologia Comparativa e do Desenvolvimento, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: Daniel Desidério
authors.initials: DD
authors.lastname: Domingues
authors.affiliation: Laboratório de Neurobiologia Comparativa e do Desenvolvimento, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: Litia Alves
authors.initials: LA
authors.lastname: de Carvalho
authors.affiliation: Laboratório de Neurobiologia Comparativa e do Desenvolvimento, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Ciências Biológicas-Biofísica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: Silvana
authors.initials: S
authors.lastname: Allodi
authors.affiliation: Laboratório de Neurobiologia Comparativa e do Desenvolvimento, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Educação Física, Universidade Federal do Rio de Janeiro, Brazil. Electronic address: clyntoncorrea@hucff.ufrj.br.
authors.forename: Clynton Lourenço
authors.initials: CL
authors.lastname: Correa
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D019317:Evidence-Based Medicine / Q000379:methods*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D042461:Vascular Endothelial Growth Factor A
keywords: Animal model; Exercise; Neuroprotective agents; Parkinson's disease