title: Post-infectious and non post-infectious irritable bowel syndrome: A comparative study.
abstract: OBJECTIVE
  To compare the post-infectious irritable bowel syndrome (PI-IBS) and none post-infectious irritable bowel syndrome (NPI-IBS) clinically and experimentally.
  
  
  METHODS
  From May 2013 to January 2015, eighty-nine patients with irritable bowel syndrome (IBS)were recruited in the internal department of the affiliated hospital of Shandong University of Traditional Chinese Medicine. The clinical data were collected for all the patients, and a blood sample was collected to detect the level of C-reactive protein (CRP) and intestinal fatty acid binding protein (IFABP), an investigation questionnaire of gastrointestinal symptom rating scale (GSRS) and self-rating anxiety scale (SAS) were carried out to evaluate the gastrointestinal function and anxiety status.
  
  
  RESULTS
  In the study, forty-eight patients were included in PI-IBS group and 41 in Non-PI-IBS group. There was no significant difference in age, gender and GSRS between the two groups (p>0.05). In PI-IBS group 70.8% patients presented with the primary symptom of diarrhea and 60.4% presented with a SAS scores over 50, but in Non-PI-IBS group, the values were only 19% (p<0.05) and 34.1% (p<0.05). The level of IFABP and CRP were significantly higher in PI-IBS group than those in Non-PI-IBS group (p<0.05).
  
  
  CONCLUSIONS
  The PI-IBS may be different from Non-PI-IBS in mechanism and should be treated using different strategies.
authors.affiliation: Dr. Jianbo Wang, Department of Digestion Internal Medicine, The Affiliated Hospital of Shandong University of, Traditional Chinese medicine, Jinan, Shandong province, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Dr. Shihua Lu, Department of Medical Affairs, The Affiliated Hospital of Shandong University of, Traditional Chinese medicine, Jinan, Shandong province, China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Lu
authors.affiliation: Dr. Shijie Zhao, Department of Digestion Internal Medicine, The Sixth People's Hospital of Jinan, Jinan, Shandong province, China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Zhao
keywords: Gastrointestinal symptom rating scale (GSRS); Intestinal fatty acid binding protein (IFABP); None post-infectious irritable bowel syndrome (NPI-IBS); Post-infectious irritable bowel syndrome (PI-IBS); Self-rating anxiety scale (SAS)