title: Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis.
abstract: OBJECTIVE
  It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk.
  
  
  METHODS
  A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size.
  
  
  RESULTS
  Eleven case-control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09-1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy-Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76-2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83-1.42).
  
  
  CONCLUSIONS
  IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.
authors.affiliation: Department of Medical Genetics and Division of Human Morbid Genomics, West China Hospital, Sichuan University, 1st Keyuan 4 Lu, High-Tech Zone, Chengdu, 610041, China.
authors.forename: Chongjuan
authors.initials: C
authors.lastname: Gu
authors.affiliation: Provincial Key Laboratory for Molecular Medicine of Major Diseases and Prevention and Treatment with Traditional Chinese Medicine of Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Gong
authors.affiliation: Department of Obstetrics and Gynecology, reproductive medicine centre, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Medical Genetics and Division of Human Morbid Genomics, West China Hospital, Sichuan University, 1st Keyuan 4 Lu, High-Tech Zone, Chengdu, 610041, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Medical Genetics and Division of Human Morbid Genomics, West China Hospital, Sichuan University, 1st Keyuan 4 Lu, High-Tech Zone, Chengdu, 610041, China. mayongxin@gmail.com.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Gene polymorphism; Interleukin-10; Meta-analysis; Recurrent pregnancy loss