title: Chromatin structure and pre-mRNA processing work together.
abstract: Chromatin is the natural context for transcription elongation. However, the elongating RNA polymerase II (RNAPII) is forced to pause by the positioned nucleosomes present in gene bodies. Here, we briefly discuss the current results suggesting that those pauses could serve as a mechanism to coordinate transcription elongation with pre-mRNA processing. Further, histone post-translational modifications have been found to regulate the recruitment of factors involved in pre-mRNA processing. This view highlights the important regulatory role of the chromatin context in the whole process of the mature mRNA synthesis.
authors.affiliation: a Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Consejo Superior de Investigaciones Científicas (CSIC) , Seville , Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Jimeno-González
authors.affiliation: a Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Consejo Superior de Investigaciones Científicas (CSIC) , Seville , Spain.
authors.forename: José C
authors.initials: JC
authors.lastname: Reyes
mesh_terms: D002843:Chromatin / Q000737:chemistry* / Q000235:genetics; D042421:Histone Code; D006657:Histones / Q000378:metabolism; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D012333:RNA, Messenger; D012319:RNA Polymerase II
keywords: mRNA capping; nucleosome; promoter proximal pausing; splicing; transcription termination