title: p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis.
abstract: p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors, though the evidence is not yet conclusive. We therefore performed a meta-analysis to explore the relationship between PAK1 and prognosis in patients with solid tumors. Relevant publications were searched in several widely used databases, and 15 studies (3068 patients) were included in the meta-analysis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between PAK1 and prognosis. Associations between PAK1 expression and prognosis were observed for overall survival (HR = 2.81, 95% CI = 1.07-7.39) and disease-specific survival (HR = 2.15, 95% CI = 1.47-3.16). No such association was detected for time to tumor progression (HR = 1.78, 95% CI = 0.99-3.21).Our meta-analysis thus indicates that PAK1 expression may be a predictive marker of overall survival and disease-specific survival in patients with solid tumors.
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Pan
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Li
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Li-Xiao
authors.initials: LX
authors.lastname: Xu
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Guang-Hao
authors.initials: GH
authors.lastname: Su
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Zhi-Heng
authors.initials: ZH
authors.lastname: Li
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Feng
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D018572:Disease-Free Survival; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D054462:p21-Activated Kinases / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C515903:PAK1 protein, human; D054462:p21-Activated Kinases
keywords: PAK1; meta-analysis; prognosis; solid tumor; survival