title: ANTIFUNGAL POTENTIAL OF PLANT SPECIES FROM BRAZILIAN CAATINGA AGAINST DERMATOPHYTES.
abstract: Trichophyton rubrum and Trichophyton mentagrophytes complex, or Trichophyton spp. are the main etiologic agents of dermatophytosis, whose treatment is limited by the high cost of antifungal treatments, their various side effects, and the emergence of resistance amongst these species. This study evaluated the in vitro antidermatophytic activity of 23 crude extracts from nine plant species of semiarid vegetation (caatinga) found in Brazil. The extracts were tested at concentrations ranging from 1.95 to 1,000.0 mg/mL by broth microdilution assay against the reference strains T. rubrum ATCC 28189 and T. mentagrophytes ATCC 11481, and 33 clinical isolates of dermatophytes. All plants showed a fungicidal effect against both fungal species, with MIC/MFC values of the active extracts ranging from 15.6 to 250.0 µg/mL. Selected extracts of Eugenia uniflora (AcE), Libidibia ferrea (AE), and Persea americana (AcE) also exhibited a fungicidal effect against all clinical isolates of T. rubrum and T. mentagrophytes complex. This is the first report of the antifungal activity of Schinus terebinthifolius, Piptadenia colubrina, Parapiptadenia rigida, Mimosa ophthalmocentra, and Persea americana against both dermatophyte species.
authors.affiliation: Departamento de Análises Clínicas, Centro de Ciências Biológicas, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
authors.forename: Renata Perugini
authors.initials: RP
authors.lastname: Biasi-Garbin
authors.affiliation: Departamento de Análises Clínicas, Centro de Ciências Biológicas, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
authors.forename: Fernanda de Oliveira
authors.initials: Fde O
authors.lastname: Demitto
authors.affiliation: Departamento de Análises Clínicas, Centro de Ciências Biológicas, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
authors.forename: Renata Claro Ribeiro do
authors.initials: RC
authors.lastname: Amaral
authors.affiliation: Departamento de Farmácia, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Magda Rhayanny Assunção
authors.initials: MR
authors.lastname: Ferreira
authors.affiliation: Departamento de Farmácia, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Luiz Alberto Lira
authors.initials: LA
authors.lastname: Soares
authors.affiliation: Departamento de Análises Clínicas, Centro de Ciências Biológicas, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
authors.forename: Terezinha Inez Estivalet
authors.initials: TI
authors.lastname: Svidzinski
authors.affiliation: Departamento de Análises Clínicas, Centro de Ciências Biológicas, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
authors.forename: Lilian Cristiane
authors.initials: LC
authors.lastname: Baeza
authors.affiliation: Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
authors.forename: Sueli Fumie
authors.initials: SF
authors.lastname: Yamada-Ogatta
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001938:Brazil; D008826:Microbial Sensitivity Tests; D064209:Phytochemicals / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D014005:Tinea / Q000188:drug therapy*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D064209:Phytochemicals; D010936:Plant Extracts