title: On the move, lysosomal CAX drives Ca2+ transport and motility.
abstract: Acidic Ca(2+)stores are important sources of Ca(2+)during cell signaling but little is known about how Ca(2+)enters these stores. In this issue, Melchionda et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201510019) identify a Ca(2+)/H(+)exchanger (CAX) that is required for Ca(2+)uptake and cell migration in vertebrates.
authors.affiliation: School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK Lloyd-EvansE@cardiff.ac.uk.
authors.forename: Emyr
authors.initials: E
authors.lastname: Lloyd-Evans
mesh_terms: D000818:Animals; D017920:Antiporters / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002465:Cell Movement; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D009432:Neural Crest / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D029867:Xenopus Proteins / Q000378:metabolism*
chemical_list: D017920:Antiporters; D029867:Xenopus Proteins; D006859:Hydrogen; D002118:Calcium