title: Effects of Berries Consumption on Cardiovascular Risk Factors: A Meta-analysis with Trial Sequential Analysis of Randomized Controlled Trials.
abstract: The effects of berries consumption on cardiovascular disease (CVD) risk factors have not been systematically examined. Here, we aimed to conduct a meta-analysis with trial sequential analysis to estimate the effect of berries consumption on CVD risk factors. PubMed, Embase, and CENTRAL were searched for randomized controlled trials (RCTs) that regarding the effects of berries consumption in either healthy participants or patients with CVD. Twenty-two eligible RCTs representing 1,251 subjects were enrolled. The pooled result showed that berries consumption significantly lowered the low density lipoprotein (LDL)-cholesterol [weighted mean difference (WMD), -0.21 mmol/L; 95% confidence interval (CI), -0.34 to -0.07; P = 0.003], systolic blood pressure (SBP) (WMD, -2.72 mmHg; 95% CI, -5.32 to -0.12; P = 0.04), fasting glucose (WMD, -0.10 mmol/L; 95% CI, -0.17 to -0.03; P = 0.004), body mass index (BMI) (WMD, -0.36 kg/m(2); 95% CI, -0.54 to -0.18, P < 0.00001), Hemoglobin A1c (HbA1c) (WMD, -0.20%; 95% CI, -0.39 to -0.01; P = 0.04) and tumor necrosis factor-α (TNF-α) (WMD, -0.99 ρg/mL; 95% CI, -1.96 to -0.02; P = 0.04). However, no significant changes were seen in other markers. The current evidence suggests that berries consumption might be utilized as a possible new effective and safe supplementary option to better prevent and control CVD in humans.
authors.affiliation: Department of Clinical Pharmacy, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, 523326, China.
authors.forename: Haohai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Pharmacy, Guangdong Province Agricultural Reclamation Central Hospital, Zhanjiang, Guangdong, 524002, China.
authors.forename: Guangzhao
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Gynaecology &Obstetrics, Dongguan Maternal &Child Health Hospital, Dongguan, Guangdong, 523112, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liao
authors.affiliation: Department of Clinical Pharmacy, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, 523326, China.
authors.forename: Yongkun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Clinical Pharmacy, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, 523326, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xue
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000178:diet therapy* / Q000378:metabolism / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C439524:TNF protein, human