title: The relationship between fibrinogen to albumin ratio and severity of coronary artery disease in patients with STEMI.
abstract: OBJECTIVE
  Previous studies show that serum fibrinogen levels are established risk factors for coronary artery disease (CAD) and that serum albumin levels are of a higher specificity and sensitivity in ST-elevation myocardial infarction (STEMI). In this study, we sought to evaluate the association between fibrinogen to albumin ratio (FAR) and the extent and severity of CAD evaluated by TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries (SYNTAX) Score (SS) in patients with STEMI.
  
  
  METHODS
  A total of 278 patients with STEMI were included in the study. FAR was calculated using specified variables. The extent and severity of CAD were evaluated using the SS. The patients were divided into low- (SS <22) and high- (SS ≥22) risk groups. A Spearman rank correlation coefficient analysis was used for the relationship between FAR and SS. The cutoff points for sensitivity and specificity of FAR in predicting SS were estimated by performing a receiver operator characteristic curve analysis.
  
  
  RESULTS
  There were significant differences in the mean age (P=.016), admission serum albumin (P=.041), serum fibrinogen (P<.001), FAR (P<.001), and SS risk groups. Positive correlation was detected between FAR and SS (r=0.458, P<.001). A cutoff level of >87 FAR predicted SS (sensitivity, 70%; specificity, 70%), and an area under the curve of 0.758 serum fibrinogen and albumin level was an independent predictor for SS in patients with STEMI (b=0.039; 95% confidence interval, 0.016-0.062; P=.001 and b=-6.906; 95% confidence interval, -12.284 to -1.527; P=.013, respectively).
  
  
  CONCLUSIONS
  In the present study, we showed that FAR is significantly related to SS in predicting the severity of CAD in patients with STEMI.
authors.affiliation: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakır, Turkey. Electronic address: oguzk2002@gmail.com.
authors.forename: Oğuz
authors.initials: O
authors.lastname: Karahan
authors.affiliation: Medical School of Dicle University, Department of Cardiology, Diyarbakır, Turkey. Electronic address: halitacet@gmail.com.
authors.forename: Halit
authors.initials: H
authors.lastname: Acet
authors.affiliation: Medical School of Dicle University, Department of Cardiology, Diyarbakır, Turkey. Electronic address: farukertas@hotmail.com.
authors.forename: Faruk
authors.initials: F
authors.lastname: Ertaş
authors.affiliation: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakır, Turkey. Electronic address: dr.orhantezcan@gmail.com.
authors.forename: Orhan
authors.initials: O
authors.lastname: Tezcan
authors.affiliation: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakır, Turkey. Electronic address: drahmetcaliskan@hotmail.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Çalişkan
authors.affiliation: Medical School of Dicle University, Department of Cardiology, Diyarbakır, Turkey. Electronic address: drmdemirr@gmail.com.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Demir
authors.affiliation: Medical School of Dicle University, Department of Cardiology, Diyarbakır, Turkey. Electronic address: kayaferhatahmet@gmail.com.
authors.forename: Ahmet Ferhat
authors.initials: AF
authors.lastname: Kaya
authors.affiliation: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakır, Turkey. Electronic address: sinandemirtas78@hotmail.com.
authors.forename: Sinan
authors.initials: S
authors.lastname: Demirtaş
authors.affiliation: Medical School of Dicle University, Department of Neurology, Diyarbakır, Turkey. Electronic address: mehmetugur.cevik@gmail.com.
authors.forename: Mehmet Uğur
authors.initials: MU
authors.lastname: Çevik
authors.affiliation: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakır, Turkey. Electronic address: celalyav@hotmail.com.
authors.forename: Celal
authors.initials: C
authors.lastname: Yavuz
mesh_terms: D000367:Age Factors; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications; D054855:Drug-Eluting Stents; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin; D005340:Fibrinogen