title: New strategies against drug resistance to herpes simplex virus.
abstract: Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.
authors.affiliation: State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Jiang
authors.affiliation: XiangYa Stomatological Hospital, Central South University, Changsha, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Center for Nanotechnology, Munster, Germany.|Institute for Nanobiomedical Technology and Membrane Biology, West China Medical School, Sichuan University, Chengdu, China.
authors.forename: Xiu-Rong
authors.initials: XR
authors.lastname: Guo
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004351:Drug Resistance; D006560:Herpes Labialis / Q000188:drug therapy*; D006801:Humans; D016867:Immunocompromised Host; D015394:Molecular Structure; D016296:Mutagenesis / Q000187:drug effects; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D013283:Stomatitis, Herpetic / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D010936:Plant Extracts; D000212:Acyclovir