title: Does Staphylococcus Saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary.
abstract: Staphylococcus saprophyticus is a well-known urinary pathogen in acute cystitis in young females. We completed a retrospective overview of the distribution of urinary tract infections (UTIs) occurring in 2014, at Semmelweis University hospitals and at Heim Pál Children's Hospital. Six age-groups (ages 0-100) were examined, with the frequency of S. saprophyticus in females being: 0.1% (0-4), 0.7%, (5-15), 7.4% (16-24), 1.2% (25-39), 0.4% (40-59) and 0.1% (60-100), and S. saprophyticus being the 3(rd) most common pathogen in females aged 16-24. In males, S. saprophyticus was only isolated from those aged 5-15. Seasonal distribution of UTIs caused by S. saprophyticus showed that most infections occurred during the months of January, June, August and November. Antibiotic-resistance rates of amoxicillin, clindamycin, doxycycline, erythromycin, gentamicin and sulfamethoxazole- trimethoprim varied as follows: 0.9%, 32.7%, 19.6%, 34.6%, 0.9% and 0.9%, respectively. Thirty randomly selected samples were analysed by pulsed-field gelelectrophoresis, and 28 different genotypes were identified. S. saprophyticus is involved in the pathogenesis of acute cystitis not only in young females, but also in other age-groups, and in young males as well. We did not find any significant seasonal occurrence in S. saprophyticus-caused UTIs. The infective strains were genetically diverse. Antibiotic-resistance does not pose any issue as of yet.
authors.affiliation: Department of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Adeghate
authors.affiliation: Department of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Emese
authors.initials: E
authors.lastname: Juhász
authors.affiliation: Department of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Júlia
authors.initials: J
authors.lastname: Pongrácz
authors.affiliation: Central Laboratory, Heim Pál Children's Hospital , Budapest , Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Rimanóczy
authors.affiliation: Department of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Kristóf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D057790:Staphylococcus saprophyticus / Q000302:isolation & purification / Q000502:physiology*; D055815:Young Adult
keywords: Staphylococcus saprophyticus; UTI; acute cystitis