title: B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS.
abstract: BACKGROUND
  Conservative fluid management increases ventilator-free days without influencing overall mortality in acute respiratory distress syndrome. Plasma concentrations of B-type natriuretic peptide (a marker of ventricular filling) or aldosterone (a marker of effective circulating volume) may identify patients for whom fluid management impacts survival.
  
  
  METHODS
  This was a retrospective analysis of the Fluid and Catheter Treatment Trial (FACTT), a randomized trial comparing conservative with liberal fluid management in acute respiratory distress syndrome. Using plasma collected at study enrollment, we measured B-type natriuretic peptide and aldosterone by immunoassay. Multivariable analyses examined the interaction between B-type natriuretic peptide or aldosterone concentration and fluid strategy with regard to 60-day in-hospital mortality.
  
  
  RESULTS
  Among 625 patients with adequate plasma, median B-type natriuretic peptide concentration was 825 pg/mL (interquartile range, 144-1,574 pg/mL), and median aldosterone was 2.49 ng/dL (interquartile range, 1.1-4.3 ng/dL). B-type natriuretic peptide did not predict overall mortality, correlate with fluid balance, or modify the effect of conservative vs liberal fluid management on outcomes. In contrast, among patients with lower aldosterone concentrations, conservative fluid management increased ventilator-free days (17.1 ± 9.8 vs 12.5 ± 10.3, P < .001) and decreased mortality (19% vs 30%, P = .03) (P value for interaction = .01).
  
  
  CONCLUSIONS
  In acute respiratory distress syndrome, B-type natriuretic peptide does not modify the effect of fluid management on outcomes. Lower initial aldosterone appears to identify patients for whom conservative fluid management may improve mortality.
authors.affiliation: Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN. Electronic address: matthew.w.semler@vanderbilt.edu.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Semler
authors.affiliation: Frist Clinic, Endocrinology, Nashville, TN.
authors.forename: Annis M
authors.initials: AM
authors.lastname: Marney
authors.affiliation: Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Todd W
authors.initials: TW
authors.lastname: Rice
authors.affiliation: Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Hui
authors.initials: H
authors.lastname: Nian
authors.affiliation: Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Chang
authors.initials: C
authors.lastname: Yu
authors.affiliation: Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Arthur P
authors.initials: AP
authors.lastname: Wheeler
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Brown
mesh_terms: D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D017063:Outcome Assessment, Health Care; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D013223:Statistics as Topic; D014882:Water-Electrolyte Balance
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D000450:Aldosterone
keywords: acute lung injury; aldosterone; brain; natriuretic peptide; water-electrolyte balance