title: DRUG THERAPY IN KNEE OSTEOARTHROSIS.
abstract: Clinical treatment for osteoarthritis (OA) is very important and is based on patient's self care and guided by the physician. Drug therapy is additional to losing weight, improving muscular strength, proprioception, flexibility and range of motion. Between the available drugs for osteoarthritis' treatment, some are basically analgesics and do not interfere on disease's progression; some are anti-inflammatory with good analgesic power but with side effects that compromise their prolonged usage; and the structure modifying drugs that slow down the progression of OA. The medications are presented in topic, oral, intra-muscular, intra-venous and intra-articular forms. The hyaluronic acid has various presentations with good analgesic effect and some evidence of structure modifying property. There is IA evidence level for the use of diacerhein and of glucosamine to slow down the disease. Still, more technology for diagnosis and therapy control of OA is necessary to define the efficacy of other drugs.
authors.affiliation: Knee Group of the Institute of Orthopedics and Traumatology, HC/FMUSP.
authors.forename: Márcia Uchôa
authors.initials: MU
authors.lastname: de Rezende
authors.affiliation: Institute of Orthopedics and Traumatology, HC/FMUSP.
authors.forename: Riccardo Gomes
authors.initials: RG
authors.lastname: Gobbi
keywords: Anthraquinone; Condroitin; Glucosamine; Hyaluronic acid; Osteoarthritis