title: Physical activity is not associated with spirometric indices in lung-healthy German youth.
abstract: In lung disease, physical activity improves lung function and reduces morbidity. However, healthy populations are not well studied. We estimate the relationship between spirometric indices and accelerometric physical activity in lung-healthy adolescents.895 nonsmoking German adolescents without chronic lung disease (45% male, mean±sd age 15.2±0.26 years) from the GINIplus and LISAplus cohorts completed questionnaires, spirometry, 7-day accelerometry and an activity diary. Physical activity was measured as minutes, quintiles and regularity of daily moderate, vigorous and moderate-to-vigorous physical activity (MVPA), participation in sport and active commuting to school. Primary outcomes were forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory flow at 25-75% of FVC; they were separately correlated with physical activity and adjusted for confounders of respiratory function, including early-life exposures.Adolescents averaged 40 min MVPA per day, typical for European youth. 79% participated in sports and 51% commuted actively. An association was suggested between 3% higher FVC (∼100 mL) and either extreme MVPA quintile or percentage of days with >30 min MVPA (p<0.05). However, after Bonferroni correction all associations between spirometry, active lifestyle and physical activity were nonsignificant.Spirometric indices were not significantly associated with active lifestyle or measures of activity in lung-healthy adolescents after adjustment for confounding and multiple-comparison artefacts.
authors.affiliation: Institute of Epidemiology 1, Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, Germany Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Maia P
authors.initials: MP
authors.lastname: Smith
authors.affiliation: Department of Paediatrics, Marien-Hospital Wesel, Wesel, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: von Berg
authors.affiliation: Department of Paediatrics, Marien-Hospital Wesel, Wesel, Germany.
authors.forename: Dietrich
authors.initials: D
authors.lastname: Berdel
authors.affiliation: Department of Pediatrics, Technical University of Munich, Munich, Germany.
authors.forename: Carl-Peter
authors.initials: CP
authors.lastname: Bauer
authors.affiliation: Leibniz Research Institute for Environmental Medicine and Medical Faculty, Deanery of Medicine, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Hoffmann
authors.affiliation: Dr von Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Koletzko
authors.affiliation: Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians University, Munich, Germany Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Nowak
authors.affiliation: Institute of Epidemiology 1, Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, Germany Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
authors.affiliation: Institute of Epidemiology 1, Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, Germany Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany schulz@helmholtz-muenchen.de.
authors.forename: Holger
authors.initials: H
authors.lastname: Schulz
mesh_terms: D000054:Acceleration; D000293:Adolescent; D001249:Asthma / Q000503:physiopathology*; D056352:Athletes; D002908:Chronic Disease; D015331:Cohort Studies; D015444:Exercise; D005260:Female; D005541:Forced Expiratory Volume; D005858:Germany; D064368:Healthy Volunteers; D006801:Humans; D008168:Lung / Q000502:physiology*; D008171:Lung Diseases; D008297:Male; D018811:Maternal Exposure; D011247:Pregnancy; D012129:Respiratory Function Tests; D012907:Smoking; D013147:Spirometry; D013177:Sports; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014797:Vital Capacity