title: Successful Treatment of Severe Immune Thrombocytopenia After Orthotopic Liver Transplant.
abstract: Here, we report a case of severe immune thrombocytopenia that occurred after orthotopic liver transplant. On day 16 after transplant, the patient was readmitted to our hospital with a platelet count of 0 cells/mL, with the count remaining at a low level of 1000 to 10 000 cells/mL for 46 days. A diagnosis was made, after exclusion of other causes, of thrombocytopenia. Platelet blood transfusion and high-dose prednisone (1mg/kg/d) combined with intravenous immunoglobulin (0.5g/kg/d) were administered with no improvement. After additional treatments, which included altered use of immunosuppressive agents, changing adefovir to lamivudine and continuous steroid therapy, the patient was discharged with a platelet count of 55 000 cells/mL. Both liver and renal functions generally stayed well during hospitalization. The patient was discharged uneventfully and achieved remission during 10-month follow-up after discharge.
authors.affiliation: From the Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Jiu-Lin
authors.initials: JL
authors.lastname: Song
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Yang
authors.forename: Lu-Nan
authors.initials: LN
authors.lastname: Yan
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage; D057915:Drug Substitution; D004359:Drug Therapy, Combination; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D017713:Platelet Transfusion; D011241:Prednisone / Q000008:administration & dosage*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D012074:Remission Induction; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D011241:Prednisone