title: Types of Ubiquitin Ligases.
abstract: Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.
authors.affiliation: MRC Protein Phosphorylation and Ubiquitylation Unit at University of Dundee, Scotland DD1 5EH, UK.
authors.forename: Francesca Ester
authors.initials: FE
authors.lastname: Morreale
authors.affiliation: MRC Protein Phosphorylation and Ubiquitylation Unit at University of Dundee, Scotland DD1 5EH, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Walden
mesh_terms: D000818:Animals; D006801:Humans; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism; D044763:Ubiquitin-Conjugating Enzymes / Q000737:chemistry* / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D011506:Proteins; D044763:Ubiquitin-Conjugating Enzymes