title: Leveraging signaling research to understand and treat disease.
abstract: This Editorial Guide describes an area of active signaling research. A challenge signaling researchers face is understanding how the information gained by analysis at the cellular and molecular levels can be translated to understanding higher-order organismal physiology and pathophysiology.
authors.affiliation: Chief Scientific Editor, Science Signaling, American Association for the Advancement of Science (AAAS), Washington, DC 20005, USA. David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. myaffe@mit.edu ngough@aaas.org.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Yaffe
authors.affiliation: Editor, Science Signaling, AAAS, Washington, DC 20005, USA. myaffe@mit.edu ngough@aaas.org.
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
mesh_terms: D000818:Animals; D006801:Humans; D015398:Signal Transduction