title: GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.
abstract: Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10-8) at 6p22.3 (rs1740828; P = 2.29 × 10-8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
authors.forename: Maxine M
authors.initials: MM
authors.lastname: Chen
authors.affiliation: Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
authors.forename: Tracy A
authors.initials: TA
authors.lastname: O'Mara
authors.affiliation: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Thompson
authors.affiliation: Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
authors.forename: Jodie N
authors.initials: JN
authors.lastname: Painter
authors.affiliation: Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.|School of Medicine and Public Health, Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, NSW 2308, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Attia
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Black
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Louise
authors.initials: L
authors.lastname: Brinton
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Chanock
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Timothy Ht
authors.initials: TH
authors.lastname: Cheng
authors.affiliation: University of New Mexico, Albuquerque, NM 87131, USA.|Division of Cancer Care, Department of Population Health Research, Alberta Health Services, Calgary, AB, Canada.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Cook
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Marta
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authors.lastname: Crous-Bou
authors.affiliation: Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA.
authors.forename: Jennifer
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authors.lastname: Doherty
authors.affiliation: Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, AB, Canada.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Friedenreich
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.|Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Garcia-Closas
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, GA 30329, USA.
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authors.initials: MM
authors.lastname: Gaudet
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Maggie
authors.initials: M
authors.lastname: Gorman
authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Haiman
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.|Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst MA 01003, USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Patricia
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authors.lastname: Hartge
authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.affiliation: Department of Clinical Genetics, St George's, University of London, London SW17 0RE, UK.
authors.forename: Shirley
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authors.affiliation: Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
authors.forename: Elizabeth G
authors.initials: EG
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authors.affiliation: Cancer Prevention Institute of California, Fremont, CA 94538, USA.
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Horn-Ross
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
authors.forename: David J
authors.initials: DJ
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authors.affiliation: University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
authors.forename: Loic
authors.initials: L
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authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Cancer Epidemiology and Prevention, M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt - Ingram Cancer Center, Vanderbilt University Medical Center, Nashville TN 27232, USA.
authors.forename: Jirong
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authors.lastname: Long
authors.affiliation: Yale University School of Public Health, New Haven, CT 06510, USA.
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authors.affiliation: H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Magliocco
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Lynn
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authors.affiliation: School of Medicine and Public Health, Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, NSW 2308, Australia.
authors.forename: Mark
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authors.lastname: McEvoy
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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authors.initials: SH
authors.lastname: Olson
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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authors.lastname: Orlow
authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Loreall
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authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
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authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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authors.affiliation: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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authors.affiliation: Yale University School of Public Health, New Haven, CT 06510, USA.
authors.forename: Harvey
authors.initials: H
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authors.affiliation: Center for Cancer Prevention (CPO-Piemonte), Turin, Italy.|Human Genetic Foundation (HuGeF), Turin, Italy.
authors.forename: Carlotta
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authors.lastname: Sacerdote
authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Frederick
authors.initials: F
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authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Veronica
authors.initials: V
authors.lastname: Wendy Setiawan
authors.affiliation: Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.|Hunter Area Pathology Service, John Hunter Hospital, Newcastle, NSW 2305, Australia.|School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW 2308, Australia.
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Scott
authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
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authors.initials: X
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authors.affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt - Ingram Cancer Center, Vanderbilt University Medical Center, Nashville TN 27232, USA.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
authors.forename: Constance
authors.initials: C
authors.lastname: Turman
authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
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authors.initials: D
authors.lastname: Van Den Berg
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
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authors.initials: Z
authors.lastname: Wang
authors.affiliation: University of Washington, Seattle, WA 19024, USA.
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authors.initials: NS
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
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authors.affiliation: University of Southern California, Los Angeles, CA 90033, USA.
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authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China and.
authors.forename: Yong-Bing
authors.initials: YB
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
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authors.initials: HP
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authors.affiliation: University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
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authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.affiliation: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.lastname: Tomlinson
authors.affiliation: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.|Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.initials: DF
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authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
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authors.affiliation: Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
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authors.lastname: Spurdle
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA, nhidv@channing.harvard.edu.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
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authors.lastname: De Vivo
mesh_terms: D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics