title: Clinical presentation, treatment and outcome in 31 dogs with presumed primary colorectal lymphoma (2001-2013).
abstract: The objective of this multicentre retrospective study was to describe clinical presentation, treatment and outcome and to determine prognostic factors for dogs with presumed primary colorectal lymphoma (PCRL). A total of 31 dogs were included. The predominant features of PCRL were high grade (n = 18) and immunophenotype B (n = 24). Most dogs were substage b (n = 25) with higher prevalence of haematochezia (n = 20). One dog had surgery only. Thirty dogs received chemotherapy; amongst them 13 had surgery or radiotherapy. Progression free survival (PFS) was 1318 days and disease-related median survival time (MST) was 1845 days. Fourteen dogs were alive at the end of the study with a median follow-up time of 684 days (3-4678 days). Younger dogs had longer PFS (P = 0.031) and disease-related MST (P = 0.01). Presence of haematochezia corresponded with longer PFS (P = 0.02). Addition of local treatment to chemotherapy did not significantly improve the outcome (P = 0.584). Canine PCRL has considerably longer PFS and MST than other forms of non-Hodgkin's lymphoma.
authors.affiliation: Royal veterinary College, Hatfield, UK.
authors.forename: I
authors.initials: I
authors.lastname: Desmas
authors.affiliation: Flint Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Burton
authors.affiliation: The Veterinary Cancer Center, Norwalk, CT, USA.
authors.forename: G
authors.initials: G
authors.lastname: Post
authors.affiliation: Chavat Daat Veterinary Speciality Center, Beit Berl, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Kristal
authors.affiliation: Mississauga Oakville Veterinary Emergency Hospital and Referral Services, Oakville, ON, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Gauthier
authors.affiliation: School of Veterinary Medicine, University of Madison-Wisconsin, Madison, WI, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Borrego
authors.affiliation: Vets Now Referrals, Medicine Service, Glasgow, UK.
authors.forename: A
authors.initials: A
authors.lastname: Di Bella
authors.affiliation: Royal veterinary College, Hatfield, UK.
authors.forename: A
authors.initials: A
authors.lastname: Lara-Garcia
mesh_terms: D000367:Age Factors; D000818:Animals; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D005260:Female; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: canine; chemotherapy; colorectal; lymphoma