title: Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity.
abstract: BACKGROUND
  Candida susceptibility commonly occurs in breast cancer patients. Of which, Candida albicans is considered as a common pathogen causing candidiasis. Martinella iquitosensis (Bignoniaceae) is one of the species belonged to Martinella, distributed widely in Amazon basin. Its root extract yielded two complex substituted tetrahydroquinolines, Martinelline and Martinellic acid which were the first natural non-peptide bradykinin receptor antagonists identified.
  
  
  RESULTS
  In this study, a novel martinelline type analogue, named 2,3,3a,4,5,9b-hexahydro-8-phenoxy-4-(pyridin-2-yl)furo[3,2-c]quinoline, was synthesized and its preliminary anticancer activity and antifungal potential were investigated. This compound showed potential anticancer activity against MDAMB-231 breast cancer cells. Meanwhile it could enhance the fungistatic activity of miconazole against Candida albicans.
  
  
  CONCLUSIONS
  These findings provide an implication for the continue investigation and development of martinelline type analogues as therapeutic agents in the future.
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Chung
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: J C-O
authors.initials: JC
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: C-H
authors.initials: CH
authors.lastname: Cheng
authors.affiliation: Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Bian
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.
authors.forename: W-Y
authors.initials: WY
authors.lastname: Wong
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: K-H
authors.initials: KH
authors.lastname: Lam
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China ; Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
authors.forename: C-H
authors.initials: CH
authors.lastname: Chui
keywords: Biological activity; Candida albicans; Hexahydrofuro[3,2-c]quinoline; Martinelline type analogue