title: Inverse Electron-Demand [4 + 2]-Cycloadditions of Ynamides: Access to Novel Pyridine Scaffolds.
abstract: Functionalized polycyclic aminopyridines are central to the chemical sciences, but their syntheses are still hampered by a number of shortcomings. These nitrogenated heterocycles can be efficiently prepared by an intramolecular inverse electron demand hetero Diels-Alder (ihDA) cycloaddition of ynamides to pyrimidines. This ihDA/rDA sequence is general in scope and affords expedient access to novel types of aminopyridinyl scaffolds that hold great promise in terms of exit vector patterns.
authors.affiliation: Laboratoire de Chimie Moléculaire, Université de Strasbourg , CNRS UMR 7509, ECPM, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Duret
authors.affiliation: Laboratoire de Chimie Moléculaire, Université de Strasbourg , CNRS UMR 7509, ECPM, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Quinlan
authors.affiliation: Medicinal Chemistry, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, CH-4070 Basel, Switzerland.
authors.forename: Rainer E
authors.initials: RE
authors.lastname: Martin
authors.affiliation: Laboratoire de Chimie Moléculaire, Université de Strasbourg , CNRS UMR 7509, ECPM, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bisseret
authors.affiliation: Department of Chemistry, University of Basel , Spitalstrasse 51, CH-4056 Basel, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Neuburger
authors.affiliation: Institut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS UMR 8182, Université. Paris-Sud, Université Paris-Saclay , bâtiment 420, 91405 Orsay cedex, France.|Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay , 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Gandon
authors.affiliation: Laboratoire de Chimie Moléculaire, Université de Strasbourg , CNRS UMR 7509, ECPM, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Blanchard