title: In Vitro Corrosion and Cytocompatibility of a Microarc Oxidation Coating and Poly(L-lactic acid) Composite Coating on Mg-1Li-1Ca Alloy for Orthopedic Implants.
abstract: Manipulating the degradation rate of biomedical magnesium alloys poses a challenge. The characteristics of a microarc oxidation (MAO), prepared in phytic acid, and poly(L-lactic acid) (PLLA) composite coating, fabricated on a novel Mg-1Li-1Ca alloy, were studied through field emission scanning electron microscopy (FE-SEM), electron probe X-ray microanalysis (EPMA), energy dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD). The corrosion behaviors of the samples were evaluated via hydrogen evolution, potentiodynamic polarization and electrochemical impedance spectroscopy in Hanks' solution. The results indicated that the MAO/PLLA composite coatings significantly enhanced the corrosion resistance of the Mg-1Li-1Ca alloy. MTT and ALP assays using MC3T3 osteoblasts indicated that the MAO/PLLA coatings greatly improved the cytocompatibility, and the morphology of the cells cultured on different samples exhibited good adhesion. Hemolysis tests showed that the composite coatings endowed the Mg-1Li-1Ca alloys with a low hemolysis ratio. The increased solution pH resulting from the corrosion of magnesium could be tailored by the degradation of PLLA. The degradation mechanism of the composite coatings was discussed. The MAO/PLLA composite coating may be appropriate for applications on degradable Mg-based orthopedic implants.
authors.affiliation: College of Materials Science and Engineering, Shandong University of Science and Technology , Qingdao 266590, China.|State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology , Qingdao 266590, China.
authors.forename: Rong-Chang
authors.initials: RC
authors.lastname: Zeng
authors.affiliation: College of Materials Science and Engineering, Shandong University of Science and Technology , Qingdao 266590, China.|State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology , Qingdao 266590, China.
authors.forename: Lan-yue
authors.initials: LY
authors.lastname: Cui
authors.affiliation: College of Materials Science and Engineering, Shandong University of Science and Technology , Qingdao 266590, China.|State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology , Qingdao 266590, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Affiliated Hospital of Qingdao University, Qingdao University , Qingdao 266590, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.affiliation: Affiliated Hospital of Qingdao University, Qingdao University , Qingdao 266590, China.
authors.forename: Bao-Dong
authors.initials: BD
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for Turbulence and Complex Systems and Department of Materials Science and Engineering, College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zheng
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003343:Corrosion; D004563:Electrochemistry; D006461:Hemolysis / Q000187:drug effects; D006859:Hydrogen / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D008094:Lithium / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D051379:Mice; D009985:Orthopedics; D010084:Oxidation-Reduction; D011091:Polyesters / Q000494:pharmacology*; D019736:Prostheses and Implants; D011817:Rabbits; D013052:Spectrometry, X-Ray Emission
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D011091:Polyesters; C033616:poly(lactide); D006859:Hydrogen; D008094:Lithium; D008274:Magnesium; D002118:Calcium
keywords: biomaterial; degradation; magnesium alloy; microarc oxidation; poly(l-lactic acid)