title: Optical Coherence Tomography Angiography of Type 2 Neovascularization in Age-Related Macular Degeneration.
abstract: Well-defined choroidal neovascularization, known as type 2 neovascularization (NV) or classic NV, is the least representative phenotype of exudative age-related macular degeneration. Clinical aspects of type 2 NV have been widely described in the literature, and to date fluorescein angiography remains the gold standard for imaging age-related macular degeneration at initial presentation. Optical coherence tomography angiography (OCT-A) can be used to image vessels based on flow characteristics without any dye injection. Type 2 NV can be visualized using OCT-A with very typical patterns. A neovascular membrane appears as either a medusa-shaped complex or a glomerulus-shaped lesion in the outer retina and the choriocapillaris layer. Furthermore, in the choriocapillaris layer, the external borders of the lesion appear as a dark ring in most cases, and one or more central feeder vessels that extend deeply into the more profound choroidal layers are visible. Identification of type 2 NV is easily feasible for any clinician using OCT-A, especially in areas where there are normally no vessels, like in subretinal space, if the interpretation rules are respected.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
authors.forename: Ala
authors.initials: A
authors.lastname: El Ameen
authors.forename: Oudy
authors.initials: O
authors.lastname: Semoun
authors.forename: Alexandra
authors.initials: A
authors.lastname: Miere
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Salomon Yves
authors.initials: SY
authors.lastname: Cohen
mesh_terms: D000792:Angiography / Q000379:methods*; D002829:Choroid / Q000098:blood supply / Q000000981:diagnostic imaging; D020256:Choroidal Neovascularization / Q000145:classification / Q000000981:diagnostic imaging*; D003941:Diagnostic Techniques, Ophthalmological; D005122:Exudates and Transudates; D006801:Humans; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000502:physiology; D058471:Subretinal Fluid; D041623:Tomography, Optical Coherence / Q000379:methods*; D057135:Wet Macular Degeneration / Q000145:classification / Q000000981:diagnostic imaging*