title: Liver X Receptor-α polymorphisms (rs11039155 and rs2279238) are associated with susceptibility to vitiligo.
abstract: Vitiligo is a complex genetic skin depigmentation disorder caused by the destruction of melanocyte from the lesional site. Liver X Receptor-α (LXR-α) expression is upregulated in the melanocytes from perilesional skin as compared to the normal skin of vitiligo patient suggesting its involvement in vitiligo pathogenesis. Polymorphisms in LXR-α have been associated with several diseases including cardiovascular disease, polycystic ovary syndrome, cancer, inflammatory bowel disease and diabetes. In this study, for the first time, we have investigated the association of LXR-α gene polymorphisms and risk of vitiligo. Sixty six vitiligo patients and 75 matched healthy control subjects who did not have any history of vitiligo or any other autoimmune disorder were recruited. The DNA isolated from patients and healthy controls was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for both rs11039155 (- 6 G > A) and rs2279238 (+ 1257 C > T) variants. Our data suggest significant association between the LXR-α gene polymorphisms and vitiligo susceptibility (rs11039155: odds ratio (OR) = 1.99, 95% CI = 1.07-3.71, p = 0.03; rs2279238: OR = 1.70, 95% CI = 1.06-2.73, p = 0.027). Our results provide an evidence that the LXR-α - 6A and + 1257T alleles contribute to risk of vitiligo in North Indian population and highlight the importance of this gene in the vitiligo pathogenesis.
authors.affiliation: Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173 234, Himachal Pradesh, India.
authors.forename: Silky
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173 234, Himachal Pradesh, India.
authors.forename: Gurjinder
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173 234, Himachal Pradesh, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Randhawa
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad Government Medical College Kangra, Tanda 176 001, Himachal Pradesh, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Mahajan
authors.affiliation: Dr. Bansal Skin Laser Center Clinic, Board Chowk, Nac Manimajra, Chandigarh 160 002, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Bansal
authors.affiliation: Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173 234, Himachal Pradesh, India.
authors.forename: Harish
authors.initials: H
authors.lastname: Changotra
keywords: Liver X Receptor; Polymorphism; Vitiligo; rs11039155; rs2279238