title: Interactions of porcine circovirus 2 with its hosts.
abstract: Porcine circovirus 2 (PCV2) can cause porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are widely presented in swine-producing countries. Since the discovery of this virus, considerable efforts have been devoted to understanding this pathogen and its interactions with its host. Here, we review the current state of knowledge on interactions between host cell factors and PCV2 with respect to viral proliferation, virus-induced cell apoptosis and autophagy, and host antiviral defenses during PCV2 infection. We also review mouse model systems for PCV2 infection.
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun, 130062, Jilin, China. renlz@jlu.edu.cn.
authors.forename: Linzhu
authors.initials: L
authors.lastname: Ren
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun, 130062, Jilin, China.
authors.forename: Xinrong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun, 130062, Jilin, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Ouyang
mesh_terms: D000818:Animals; D018173:Circoviridae Infections / Q000821:virology*; D017925:Circovirus / Q000472:pathogenicity*; D013552:Swine; D013553:Swine Diseases / Q000821:virology*
keywords: Cell; Infection; Interaction; Open reading frame (ORF); Porcine circovirus 2 (PCV2); Signaling pathway