title: Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏.
abstract: OBJECTIVE
  Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis.
  
  
  METHODS
  We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin.
  
  
  RESULTS
  We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis.
  
  
  CONCLUSIONS
  Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes.
authors.affiliation: a Immunology Department , School of Medicine and Health Sciences, Group of Public Health Research, Rosario University , Bogota Colombia.
authors.forename: Alejandra
authors.initials: A
authors.lastname: de-la-Torre
authors.affiliation: b Biomedical Research Center, Faculty of Health Sciences , Quindio University, Group of Molecular Parasitology (GEPAMOL), Armenia , Quindio , Colombia.
authors.forename: Juanita
authors.initials: J
authors.lastname: Valdes-Camacho
authors.affiliation: c MERSI, Ocular Immunology and Uveitis Foundation , Cambridge , Massachusetts , USA.
authors.forename: C Stephen
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000473:pathology; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D001082:Aqueous Humor / Q000821:virology; D001284:Atrophy; D004359:Drug Therapy, Combination; D015828:Eye Infections, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D018258:Herpesvirus 2, Human / Q000302:isolation & purification; D006801:Humans; D007498:Iris / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000175:diagnosis; D009798:Ocular Hypertension / Q000175:diagnosis; D014606:Uveitis, Anterior / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents
keywords: Anterior; bilateral; herpes simplex virus (HSV); herpetic; uveitis