title: Novel domino procedures for the synthesis of chromene derivatives and their isomerization.
abstract: Novel tricyclic keto diesters have been synthesized by a one-pot three-component procedure via DABCO-catalyzed domino Knoevenagel-Michael addition reactions. Also, an efficient four-component reaction for the synthesis of another new group of tricyclic keto diesters has been developed via domino Knoevenagel-intramolecular oxo-Diels-Alder reactions. A selective thermal isomerization of the synthesized chromenes to fumarates is also described. X-ray analyses confirm unambiguously the structures of the products.
authors.affiliation: School of Chemistry, University College of Science, University of Tehran, Tehran, Iran. zonouzi70@gmail.com.|Pharmaceutical and Cosmetic Research Center (PCRC), University of Tehran Research Institute, Tehran, Iran. zonouzi70@gmail.com.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Zonouzi
authors.affiliation: School of Chemistry, University College of Science, University of Tehran, Tehran, Iran.|Pharmaceutical and Cosmetic Research Center (PCRC), University of Tehran Research Institute, Tehran, Iran.
authors.forename: Zakieh
authors.initials: Z
authors.lastname: Izakian
authors.affiliation: Department of Chemistry, University of Malaya, 50603, Kuala Lumpour, Malaysia.|Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Seik Weng
authors.initials: SW
authors.lastname: Ng
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D061565:Cycloaddition Reaction; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001578:Benzopyrans; D006571:Heterocyclic Compounds
keywords: Chromene; DABCO; Domino reaction; Iminolactone; Isomerization; MCRs; Michael addition; Oxo-Diels–Alder