title: In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives.
abstract: A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results.
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. mmsghorab@yahoo.com.|Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo 113701, Egypt. mmsghorab@yahoo.com.
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Ghorab
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. msalsaid@ksu.edu.sa.
authors.forename: Mansour S
authors.initials: MS
authors.lastname: Alsaid
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. msdosari@yahoo.com.
authors.forename: Mohammed S
authors.initials: MS
authors.lastname: Al-Dosari
authors.affiliation: Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo 113701, Egypt. marwagalalgazzar@yahoo.com.
authors.forename: Marwa G
authors.initials: MG
authors.lastname: El-Gazzar
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. arbabssn@gmail.com.
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Arbab
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D013449:Sulfonamides / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D013449:Sulfonamides; D013890:Thiourea
keywords: anticancer activity; sulfonamides; synthesis; thioureido