title: [Immunopathology of psoriasis: from bench to bedside].
abstract: Psoriasis is a frequent inflammatory disease that involves mostly the skin and sometimes the joints. This chronic disease is rarely life-threatening but impairs significantly the patient's quality of life. It is characterized, in its typical form, by erythematous and squamous plaques with well-defined borders, associated with increased proliferation of the keratinocytes, inflammation and greater number of dilated blood vessels in the upper dermis. A role of Th1 CD4 T cells was initially suspected. More recently, Th17 CD4 T cells have been shown to play a major role in the disease. It has led to the development of Th17 inhibitors, such as anti-IL-23 (cytokine that induces Th17 CD4 T cell differentiation), anti-IL-17, anti-IL-17RA (IL-17 receptor) and anti-IL-22 (cytokines that are notably produced by Th17 CD4 T cells).
authors.affiliation: Inserm U976, laboratoire oncodermatologie, immunologie et cellules souches cutanées, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Adèle
authors.initials: A
authors.lastname: de Masson
authors.affiliation: Inserm U976, laboratoire oncodermatologie, immunologie et cellules souches cutanées, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Bouaziz
authors.affiliation: Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - Laboratoire de pathologie, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Inserm U1165, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Battistella
authors.affiliation: Inserm U976, laboratoire oncodermatologie, immunologie et cellules souches cutanées, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Bagot
authors.affiliation: Inserm U976, laboratoire oncodermatologie, immunologie et cellules souches cutanées, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - OREGA Biotech, 15, chemin du Saquin, 69130 Écully, France.
authors.forename: Armand
authors.initials: A
authors.lastname: Bensussan
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology; D011565:Psoriasis / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D012867:Skin / Q000166:cytology / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology