title: Treatment satisfaction, preferences and perception gaps between patients and physicians in the ulcerative colitis CARES study: A real world-based study.
abstract: BACKGROUND
  Ulcerative colitis (UC) is a life time disease and issues with therapy may impact on patient satisfaction and treatment preferences.
  
  
  OBJECTIVE
  To assess disease and treatment perception gaps from patients' and physicians' perspectives in UC patients.
  
  
  METHODS
  Adult patients with moderate-to-severe UC (Mayo score ≥6) naïve to biologic therapy were enrolled in a European, observational, cross-sectional, retrospective study. Treatment satisfaction was assessed by the TSQM questionnaire and treatment preferences and patient's knowledge with pre-defined questions. Physicians' and patients' perceptions were compared through the level of agreement.
  
  
  RESULTS
  256 patients from 11 European countries were included. 48.0% of patients were dissatisfied with their current treatment. Effectiveness, long lasting action, rapid start of action, and fewer side effects were the attributes more frequently considered important or very important by patients (96.9%, 89.1%, 83.8%, and 81.8%, respectively). 26.2% patients rated their overall disease knowledge as very knowledgeable. The agreement between patients' and physicians on disease severity was good (kappa=0.62).
  
  
  CONCLUSIONS
  Half patients with moderate-to-severe UC managed with conventional therapy, are dissatisfied with their treatments. Effectiveness, long lasting action and rapidity of action were the most frequently rated items in treatment preferences. There are major gaps between physicians and patients when evaluating disease burden.
authors.affiliation: Department of Hepato-Gastroenterology and Inserm U954, University Hospital of Nancy, Lorraine University, Vandoeuvre-lès-Nancy, France. Electronic address: peyrinbiroulet@gmail.com.
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
authors.affiliation: Division of Gastroenterology, University Hospitals Leuven, Leuven Belgium.
authors.forename: Gert
authors.initials: G
authors.lastname: Van Assche
authors.affiliation: Department of Gastroenterology, DRK Kliniken Berlin I Westend, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Sturm
authors.affiliation: Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
authors.affiliation: Gastroenterology Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Gaya
authors.affiliation: Gastroenterology Practice, Minden, Germany.
authors.forename: Bern
authors.initials: B
authors.lastname: Bokemeyer
authors.affiliation: Department of Gastroenterology, Evangelismos Hospital, Athens, Greece.
authors.forename: Gerassimos J
authors.initials: GJ
authors.lastname: Mantzaris
authors.affiliation: IBD Unit, Complesso Integrato Columbus, Catholic University, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Armuzzi
authors.affiliation: Gastroenterology and IBD Unit, Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom.
authors.forename: Shaji
authors.initials: S
authors.lastname: Sebastian
authors.affiliation: IMS Health, Real World Evidence Solutions, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Lara
authors.affiliation: IMS Health, Real World Evidence Solutions, Spain.
authors.forename: Mark
authors.initials: M
authors.lastname: Lynam
authors.affiliation: IMS Health, Real World Evidence Solutions, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Rojas-Farreras
authors.affiliation: Merck & Co., Inc., Kenilworth, NJ, United States.
authors.forename: Tao
authors.initials: T
authors.lastname: Fan
authors.affiliation: Merck & Co., Inc., Kenilworth, NJ, United States.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ding
authors.affiliation: Merck & Co., Inc., Kenilworth, NJ, United States.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Black
authors.affiliation: Merck & Co., Inc., Kenilworth, NJ, United States.
authors.forename: Sumesh
authors.initials: S
authors.lastname: Kachroo
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D005060:Europe; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017060:Patient Satisfaction; D010817:Physician-Patient Relations; D010820:Physicians; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Inflammatory bowel disease; Unmet needs