title: Transition-metal-free cascade reaction of α-halo-N-tosylhydrazones, indoles and arylboronic acids.
abstract: α-Halo-N-tosylhydrazones are employed as reagents for the formation of multiple carbon-carbon bonds in the three-component reactions. In this transformation, a strategy has been designed to generate the diazo intermediate by using a nucleophile to react with the azoalkene intermediate generated in situ from the α-halo-N-tosylhydrazone. The diazo intermediate thus generated further undergoes transition-metal-free C-C bond forming reaction with arylboronic acids.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China. wangjb@pku.edu.cn.
authors.forename: Guojiao
authors.initials: G
authors.lastname: Wu
authors.forename: Yifan
authors.initials: Y
authors.lastname: Deng
authors.forename: Haiqing
authors.initials: H
authors.lastname: Luo
authors.forename: Junliang
authors.initials: J
authors.lastname: Zhou
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D014105:Tosyl Compounds / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D006835:Hydrazones; D007202:Indicators and Reagents; D007211:Indoles; D014105:Tosyl Compounds; D028561:Transition Elements; D002244:Carbon