title: Scientific Advances in Lung Cancer 2015.
abstract: Lung cancer continues to be a major global health problem; the disease is diagnosed in more than 1.6 million new patients each year. However, significant progress is underway in both the prevention and treatment of lung cancer. Lung cancer therapy has now emerged as a "role model" for precision cancer medicine, with several important therapeutic breakthroughs occurring during 2015. These advances have occurred primarily in the immunotherapy field and in treatments directed against tumors harboring specific oncogenic drivers. Our knowledge about molecular mechanisms for oncogene-driven tumors and about resistance to targeted therapies has increased quickly over the past year. As a result, several regulatory approvals of new agents that significantly improve survival and quality of life for patients with lung cancer who have advanced disease have occurred. The International Association for the Study of Lung Cancer has gathered experts in different areas of lung cancer research and management to summarize the most significant scientific advancements related to prevention and therapy of lung cancer during the past year.
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas.
authors.forename: Anne S
authors.initials: AS
authors.lastname: Tsao
authors.affiliation: San Luigi Hospital, University of Turin, Orbassano, Italy.
authors.forename: Giorgio V
authors.initials: GV
authors.lastname: Scagliotti
authors.affiliation: Division of Medical Oncology, University of Colorado Cancer Center, Aurora, Colorado.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Bunn
authors.affiliation: Division of Medical Oncology, The Ohio State University, Columbus, Ohio.
authors.forename: David P
authors.initials: DP
authors.lastname: Carbone
authors.affiliation: Department of Radiation Oncology, Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Graham W
authors.initials: GW
authors.lastname: Warren
authors.affiliation: Shanghai Respiratory Research Institute, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, People's Republic of China.
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
authors.affiliation: Erasmus Medical Center, University Medical Center Rotterdam, Department of Public Health, Rotterdam, The Netherlands.
authors.forename: Harry J
authors.initials: HJ
authors.lastname: de Koning
authors.affiliation: Erasmus Medical Center, University Medical Center Rotterdam, Department of Public Health, Rotterdam, The Netherlands.
authors.forename: A Uraujh
authors.initials: AU
authors.lastname: Yousaf-Khan
authors.affiliation: Fiona Stanley Hospital, Murdoch, Western Australia and University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Annette
authors.initials: A
authors.lastname: McWilliams
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University Health Network and Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
authors.forename: Ming Sound
authors.initials: MS
authors.lastname: Tsao
authors.affiliation: Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Prasad S
authors.initials: PS
authors.lastname: Adusumilli
authors.affiliation: Department of Thoracic Surgery, Hospital Universitari Mutua Terrassa, University of Barcelona, Barcelona, Spain; Centros de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES) Lung Cancer Group, Terrassa, Barcelona, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Rami-Porta
authors.affiliation: Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Asamura
authors.affiliation: Department of Thoracic and Vascular Surgery, Antwerp University Hospital, Edegem (Antwerp), Belgium.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Van Schil
authors.affiliation: Division of Thoracic Surgery University of Toronto, Toronto, Canada.
authors.forename: Gail E
authors.initials: GE
authors.lastname: Darling
authors.affiliation: Department of Hematology & Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Suresh S
authors.initials: SS
authors.lastname: Ramalingam
authors.affiliation: Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Gomez
authors.affiliation: Department of Radiation Oncology at Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Rosenzweig
authors.affiliation: Department of Oncology, HFR Fribourg, Fribourg, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Zimmermann
authors.affiliation: Department of Oncology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Solange
authors.initials: S
authors.lastname: Peters
authors.affiliation: Chao Family Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Medicine, University of California Irvine School of Medicine, Orange, California.
authors.forename: Sai-Hong
authors.initials: SH
authors.lastname: Ignatius Ou
authors.affiliation: Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Thanyanan
authors.initials: T
authors.lastname: Reungwetwattana
authors.affiliation: Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
authors.forename: Pasi A
authors.initials: PA
authors.lastname: Jänne
authors.affiliation: Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, People's Republic of China.
authors.forename: Tony S
authors.initials: TS
authors.lastname: Mok
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, California.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Wakelee
authors.affiliation: Department of Medicine I, Medical University of Vienna, Vienna, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Pirker
authors.affiliation: Larrey Hospital, Paul Sabatier University, Toulouse, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Mazières
authors.affiliation: Johns Hopkins Kimmel Cancer Center, Johns Hopkins, Baltimore, Maryland.
authors.forename: Julie R
authors.initials: JR
authors.lastname: Brahmer
authors.affiliation: Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven, New Haven, Connecticut.
authors.forename: Roy S
authors.initials: RS
authors.lastname: Herbst
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas.
authors.forename: Vassiliki A
authors.initials: VA
authors.lastname: Papadimitrakopoulou
authors.affiliation: Fred Hutchinson Cancer Research Center, Public Health Sciences Division Seattle, Washington.
authors.forename: Mary W
authors.initials: MW
authors.lastname: Redman
authors.affiliation: International Association for the Study of Lung Cancer, Aurora, Colorado.
authors.forename: Murry W
authors.initials: MW
authors.lastname: Wynes
authors.affiliation: Thoracic Oncology Program, UC Davis Comprehensive Cancer Center, Sacramento, California.
authors.forename: David R
authors.initials: DR
authors.lastname: Gandara
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center Johns Hopkins, Johns Hopkins, Baltimore, Maryland.
authors.forename: Ronan J
authors.initials: RJ
authors.lastname: Kelly
authors.affiliation: Division of Medical Oncology, University of Colorado Cancer Center, Aurora, Colorado. Electronic address: Fred.Hirsch@ucdenver.edu.
authors.forename: Fred R
authors.initials: FR
authors.lastname: Hirsch
authors.affiliation: Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York.
authors.forename: Harvey I
authors.initials: HI
authors.lastname: Pass
mesh_terms: D006801:Humans; D007167:Immunotherapy; D008175:Lung Neoplasms / Q000175:diagnosis / Q000628:therapy*; D057285:Precision Medicine; D011788:Quality of Life
keywords: Adjuvant chemotherapy; Biomarkers; Cancer prevention; Gene mutations; Immunotherapy; Lung cancer; Master protocols; Pathology; Radiotherapy; Screening; Smoking cessation; Staging; Surgery; Targeted therapy; Value of therapy