title: Serum Vitamin D Levels in Patients with Acute Anterior Uveitis.
abstract: OBJECTIVE
  To evaluate serum 25-hydroxyvitamin D levels in patients with acute anterior uveitis (AAU).
  
  
  METHODS
  This observational case-control study involved 20 patients with AAU, and 20 consecutive, age and sex-matched healthy subjects without any ocular or systemic diseases. Serum 25-hydroxyvitamin D was quantified with electrochemiluminescence technique.
  
  
  RESULTS
  No significant differences were found between the groups with respect to age (p = 0.185) and sex (p = 0.465). Serum vitamin D levels of the subjects with AAU (mean 5.75 ± 4.50 ng/mL, median 4.00 ng/mL, range: 3.00-19.00 ng/mL) were significantly lower than the control group (mean 12.96 ± 5.89 ng/mL, median 11.00 ng/mL, range: 5.20-25.92 ng/mL) (p<0.001).
  
  
  CONCLUSIONS
  We found significantly low serum levels of vitamin D in patients with AAU, which suggest that vitamin D deficiency may play a role in the pathogenesis of anterior uveitis. Further studies are necessary to demonstrate the efficacy of vitamin D supplementation in the management of patients with anterior uveitis.
authors.affiliation: a Mevlana University School of Medicine , Department of Ophthalmology , Konya , Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Dadaci
authors.affiliation: b Ophthalmology Clinics, Turkish Red Crescent Hospital , Konya , Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Cetinkaya
authors.affiliation: a Mevlana University School of Medicine , Department of Ophthalmology , Konya , Turkey.
authors.forename: Nursen
authors.initials: N
authors.lastname: Oncel Acir
authors.affiliation: c Mevlana University School of Medicine , Department of Clinical Biochemistry , Konya , Turkey.
authors.forename: Mufide
authors.initials: M
authors.lastname: Oncel
authors.affiliation: a Mevlana University School of Medicine , Department of Ophthalmology , Konya , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Borazan
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014606:Uveitis, Anterior / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Acute anterior uveitis; immune system; pathogenesis; rheumatologic diseases; vitamin D