title: Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents.
abstract: BACKGROUND
  Oxidative stress has been suggested as a major cause of elevated blood pressure (BP) and reduced heart rate variability (HRV) due to air pollution. We hypothesized that the associations of air pollution exposure with BP and HRV are modified by oxidative stress gene polymorphisms.
  
  
  METHODS
  Between 2008 and 2010, we conducted up to 5 surveys of 547 elderly participants, measured their BP and HRV, and genotyped 47 single nucleotide polymorphisms (SNPs) in 18 oxidative stress genes. Linear mixed models were constructed to evaluate the associations of particulate matter ≤10 μm, nitrogen dioxide, and sulfur dioxide with BP and HRV, as well as the modifications of these associations by the genotyped SNPs.
  
  
  RESULTS
  Single-SNP analyses revealed interactions between air pollution and 15 SNPs (for BP) and 33 SNPs (for HRV) (all, P for interaction < 0.05). When we generated genetic risk scores for BP and HRV, using the SNPs with interactions in the single-SNP models, we found that associations of air pollution exposure with BP and HRV were modified by the genetic risk scores (P for interaction < 0.05).
  
  
  CONCLUSIONS
  These results strongly suggest that the associations of air pollution with BP and HRV are mediated by oxidative stress pathways.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyoung-Nam
authors.initials: KN
authors.lastname: Kim
authors.affiliation: Department of Bioscience and Bioengineering, Sejong University, Seoul, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Seoul Metropolitan Institute of Public Health and Environment, Seoul, Republic of Korea.
authors.forename: Kweon
authors.initials: K
authors.lastname: Jung
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. ychong1@snu.ac.kr.|Institute of Environmental Medicine, Medical Research Center, Seoul, Republic of Korea. ychong1@snu.ac.kr.|Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea. ychong1@snu.ac.kr.
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
mesh_terms: D000368:Aged; D000393:Air Pollutants / Q000633:toxicity; D000397:Air Pollution / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects*; D002947:Cities; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007723:Korea; D008297:Male; D009585:Nitrogen Dioxide / Q000633:toxicity; D018384:Oxidative Stress / Q000235:genetics*; D052638:Particulate Matter / Q000633:toxicity; D020641:Polymorphism, Single Nucleotide; D013458:Sulfur Dioxide / Q000633:toxicity
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D013458:Sulfur Dioxide; D009585:Nitrogen Dioxide
keywords: Air pollution; Blood pressure; Genetic factors; Heart rate variability; Oxidative stress