title: Hospital Incidence and Mortality Rates of Sepsis.
abstract: BACKGROUND
  Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world. To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking.
  
  
  METHODS
  Nationwide case-related hospital DRG statistics for the years 2007-2013 were used to determine the in-hospital incidence and mortality of sepsis. Cases were identified on the basis of the clinical and pathogen-based ICD-10 codes for sepsis. The statistical evaluation was standardized for age and sex and carried out separately for each age group.
  
  
  RESULTS
  The number of cases of sepsis rose by an average of 5.7% per year, from 200 535 in 2007 to 279 530 in 2013, corresponding to an increase in the adjusted in-hospital incidence from 256 to 335 cases per 100 000 persons per year. The percentage of patients with severe sepsis rose from 27% to 41%. The in-hospital mortality of sepsis fell over the same period by 2.7%, to 24.3%. In 2013, 67 849 persons died of sepsis in German hospitals (or died of another disease, but also had sepsis). The incidence was highest in the youngest and oldest age groups, and the in-hospital mortality rose nearly linearly with age from age 40 onward.
  
  
  CONCLUSIONS
  Sepsis and death from sepsis are markedly more common in Germany than previously assumed, and they are on the rise. Sepsis statistics should become a standard component of federal statistical reports on public health, as well as of hospital statistics. Preventive measures and evidencebased treatment should be implemented across the nation.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine and Integrated Research and Treatment Center for Sepsis Control and Care (CSCC), Jena University Hospital, Pharmacy and Integrated Research and Treatment Center for Sepsis Control and Care (CSCC), Jena University Hospital, Department of Respiratory Medicine, Hannover Medical School and German Center for Lung Research, Department for Medical Controlling, Jena University Hospital.
authors.forename: Carolin
authors.initials: C
authors.lastname: Fleischmann
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Thomas-Rueddel
authors.forename: Michael
authors.initials: M
authors.lastname: Hartmann
authors.forename: Christiane S
authors.initials: CS
authors.lastname: Hartog
authors.forename: Tobias
authors.initials: T
authors.lastname: Welte
authors.forename: Steffen
authors.initials: S
authors.lastname: Heublein
authors.forename: Ulf
authors.initials: U
authors.lastname: Dennler
authors.forename: Konrad
authors.initials: K
authors.lastname: Reinhart
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000401:mortality*; D003953:Diagnosis-Related Groups / Q000706:statistics & numerical data*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data* / Q000639:trends; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D012307:Risk Factors; D018805:Sepsis / Q000401:mortality*; D017678:Sex Distribution; D015996:Survival Rate; D055815:Young Adult