title: Paternity testing that involves a DNA mixture.
abstract: Here we analyse a complex disputed paternity case, where the DNA of the putative father was extracted from his corpse that had been inhumed for over 20 years. This DNA was contaminated and appears to be a mixture of at least two individuals. Furthermore, the mother's DNA was not available. The DNA mixture was analysed so as to predict the most probable genotypes of each contributor. The major contributor's profile was then used to compute the likelihood ratio for paternity. We also show how to take into account a dropout allele and the possibility of mutation in paternity testing.
authors.affiliation: Università Roma Tre, Via Silvio D'Amico, 77, 00145 Roma, Italy. Electronic address: julia.mortera@uniroma3.it.
authors.forename: Julia
authors.initials: J
authors.lastname: Mortera
authors.affiliation: Università di Roma Sapienza, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Vecchiotti
authors.affiliation: Università di Roma Sapienza, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Zoppis
authors.affiliation: Università Roma Tre, Via Silvio D'Amico, 77, 00145 Roma, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Merigioli
mesh_terms: D001842:Bone and Bones / Q000737:chemistry; D004247:DNA / Q000235:genetics*; D059018:DNA Contamination; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D010334:Paternity
chemical_list: D004247:DNA
keywords: DNA mixtures; Deconvolution; Disputed paternity; Dropout allele; Likelihood ratio; Mutation