title: Evaluation of Patient Tolerance and Small-Bowel Distention With a New Small-Bowel Distending Agent for Enterography.
abstract: OBJECTIVE
  The objective of our study was to compare a flavored beverage containing a thickening agent for enterography with a low-Hounsfield-value barium suspension for side effects, taste, subjects' willingness to repeat the drinking protocol, and small-bowel distention.
  
  
  METHODS
  The following five drinking protocols were administered to 10 volunteers: 1000 mL of flavored beverage followed by 350 mL of water, 1500 mL of flavored beverage, 900 mL of low-Hounsfield-value barium suspension followed by 450 mL of water, 1350 mL of low-Hounsfield-value barium suspension followed by 150 mL of water, and 1500 mL of water. MR images were obtained 50 and 60 minutes after initiation of drinking. Subjects completed a questionnaire evaluating the side effects, the taste of the drink, and their willingness to repeat the drinking protocol. Reviewers assigned scores evaluating small-bowel distention and ranked the examinations in order of preference.
  
  
  RESULTS
  There was no significant difference in nausea or vomiting among the protocols (p = 0.20 and 0.42, respectively), but larger volumes of flavored beverage and low-Hounsfield-value barium suspension resulted in more cramping and diarrhea (p = 0.001 and 0.002, respectively). The taste of the low-Hounsfield-value barium suspension was rated the worst (p < 0.0001). The subjects' willingness to repeat the drinking protocol was highest for the 1000 mL of flavored beverage or water alone (p < 0.05). There were no significant differences in subjective small-bowel distention except that water was rated the worst by two of the three readers (p < 0.02). There was no significant difference in the diameter of the most dis-tended small bowel for any segment or reader (p > 0.23).
  
  
  CONCLUSIONS
  A flavored beverage containing a thickening agent has a similar side effect profile and results in equivalent small-bowel distention compared with a low-Hounsfield-value barium suspension, but subjects rate taste and their willingness to repeat the drinking protocol higher for this new agent.
authors.affiliation: 1 Division of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.
authors.forename: Amy B
authors.initials: AB
authors.lastname: Kolbe
authors.affiliation: 1 Division of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.
authors.forename: Joel G
authors.initials: JG
authors.lastname: Fletcher
authors.affiliation: 1 Division of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.
authors.forename: Adam T
authors.initials: AT
authors.lastname: Froemming
authors.affiliation: 1 Division of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.
authors.forename: Shannon P
authors.initials: SP
authors.lastname: Sheedy
authors.affiliation: 1 Division of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.
authors.forename: Chi Wan
authors.initials: CW
authors.lastname: Koo
authors.affiliation: 2 Mayo School of Graduate Medical Education, Rochester, MN.
authors.forename: Krishna
authors.initials: K
authors.lastname: Pundi
authors.affiliation: 3 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
authors.forename: David H
authors.initials: DH
authors.lastname: Bruining
authors.affiliation: 4 Division of Pediatric Gastroenterology, Mayo Clinic, Rochester, MN.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Tung
authors.affiliation: 5 Division of Biostatistics, Mayo Clinic, Rochester, MN.
authors.forename: William S
authors.initials: WS
authors.lastname: Harmsen
authors.affiliation: 1 Division of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.
authors.forename: John M
authors.initials: JM
authors.lastname: Barlow
authors.affiliation: 1 Division of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.
authors.forename: Jeff L
authors.initials: JL
authors.lastname: Fidler
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001466:Barium Sulfate / Q000008:administration & dosage*; D003287:Contrast Media / Q000008:administration & dosage*; D003938:Diagnostic Techniques, Digestive System; D004106:Dilatation; D005260:Female; D005421:Flavoring Agents / Q000008:administration & dosage; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D057240:Patient Preference; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D005421:Flavoring Agents; D001466:Barium Sulfate
keywords: distention; enterography; inflammatory bowel disease; oral contrast material; small bowel