title: A comparative study between limb-salvage and amputation for treating osteosarcoma.
abstract: OBJECTIVE
  Osteosarcoma is an aggressive malignant neoplasm, and conflicting findings have been reported on the survival and function recovery in osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared clinical outcomes regarding limb salvage surgery vs. amputation for osteosarcoma patients by a meta-analysis.
  
  
  METHODS
  Literature search was conducted in CNKI, Medline, Embase, the Cochrane Database, and Web of Sciences, and the quality of included studies was evaluated based on Newcastle-Ottawa scale quality assessment. Odds ratio and 95% confidence interval of the local recurrence, 5-year overall survival, and metastasis occurrence were calculated.
  
  
  RESULTS
  17 articles were included according to selection criteria. There were 1343 patients in total derived from these studies. Our result showed that there was no significant difference between limb salvage surgery and amputation with respect to local recurrence, and patients with limb salvage surgery had a higher 5-year overall survival, and a lower metastasis occurrence.
  
  
  CONCLUSIONS
  The present study provided more comprehensive evidences to support limb salvage surgery as an optimal treatment of osteosarcoma patients.
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650118, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wan
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Dongqi
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Zhongqin
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Mingyan
authors.initials: M
authors.lastname: Ren
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Shunling
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Su
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Yihao
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Radiology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650118, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, PR China.
authors.forename: Zuozhang
authors.initials: Z
authors.lastname: Yang
keywords: Amputation; LSS, limb salvage surgery; Limb-salvage treatment; Meta-analysis; Osteosarcoma