title: [Relationship between body weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus].
abstract: OBJECTIVE
  To explore the relationship between weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  The data of 14 population samples from China Multicenter Collaborative Study of Cardiovascular Epidemiology conducted in 1998 were used. Approximately 1 000 men and women in each sample were surveyed for cardiovascular disease risk factors, including body weight at age 25 years. The body mass index (BMI) at the age 25 years was calculated. The association between body weight in early adulthood and body weight change at middle age and T2DM was examined by using logistic regression model.
  
  
  RESULTS
  The incidence of T2DM in low weight group (BMI<18.5 kg/m(2)), normal weight group (BMI: 18.5-23.9 kg/m(2)), overweight group (BMI: 24.0-27.9 kg/m(2)) and obese group (BMI:≥28.0 kg/m(2)) at 25 years old were 2.4%(30/1263), 2.8%(266/9562), 4.0%(70/1739) and 6.4% (7/110), respectively (P value for trend<0.01). The incidence of T2DM for adults with weight change <-7.5 kg, -7.5--2.6 kg, -2.5-2.5 kg, 2.6-7.5 kg, 7.6-12.5 kg and >12.5 kg at middle age were 2.5% (18/712), 1.3%(21/1629), 2.1%(48/2330), 2.3%(59/2585), 3.7%(94/2518), and 4.6% (133/2900) respectively. (P value for trend <0.01), Multivariate logistic regression analysis showed that overweight and obesity at age 25 years and subsequent weight gain were positively correlated with T2DM after adjusted other risk factors (all P values for trend <0.01).
  
  
  CONCLUSIONS
  Overweight and obesity in early adulthood and weight gain at middle age were both independently associated with the increased risk of T2DM in middle-aged men and women.
authors.affiliation: National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zhou
authors.affiliation: National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Liancheng
authors.initials: L
authors.lastname: Zhao
authors.affiliation: National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Min
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Yangfeng
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D015430:Weight Gain