title: Cardiac Sarcoma Arising From Malignant Transformation of a Preexisting Atrial Myxoma.
abstract: A 49-year-old man presented with shortness of breath on exertion, orthopnea, and chest pain. On transthoracic echocardiography, a myxomatous mass was seen in the left atrium. A diagnosis of atrial myxoma was made and the patient underwent urgent surgical intervention. At operation, the mass, which extended into the anterior leaflet of the mitral valve, was excised. Histopathologic examination showed a primary cardiac sarcoma arising within a preexisting atrial myxoma. The patient received no further treatment and died 7 months postoperatively. We report the first case of a malignant transformation of an atrial myxoma to a cardiac sarcoma.
authors.affiliation: Department of Cardiothoracic Surgery, St. Bartholomew's Hospital, West Smithfield, London, United Kingdom.
authors.forename: Anita
authors.initials: A
authors.lastname: Nguyen
authors.affiliation: Department of Cardiothoracic Surgery, St. Bartholomew's Hospital, West Smithfield, London, United Kingdom. Electronic address: wael.awad@bartshealth.nhs.uk.
authors.forename: Wael I
authors.initials: WI
authors.lastname: Awad
mesh_terms: D001707:Biopsy, Needle; D006348:Cardiac Surgical Procedures / Q000379:methods; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018450:Disease Progression; D004417:Dyspnea / Q000175:diagnosis / Q000209:etiology; D004452:Echocardiography / Q000379:methods; D017809:Fatal Outcome; D006325:Heart Atria / Q000473:pathology / Q000601:surgery; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D064266:Preexisting Condition Coverage; D035583:Rare Diseases; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery