title: Protective effect of Devosia sp. ANSB714 on growth performance, serum chemistry, immunity function and residues in kidneys of mice exposed to deoxynivalenol.
abstract: This study was conducted to investigate the toxic effects of deoxynivalenol (DON) and the ameliorating efficacy of Devosia sp. ANSB714 for the negative effects of DON on mice. In the experiment, 80 mice were randomly divided into 4 treatments: non-toxin control, toxin, non-toxin control + ANSB714 and toxin + ANSB714. During 28 days, the mice in treatment with 4.70 mg/kg DON only had significantly lower average daily gain as compared those with non-toxin control treatment (P < 0.05). Serum blood urea nitrogen, tumour necrosis factor-α and the residues of DON in kidneys in mice received the toxin diet were obviously higher than those with non-toxin control (P < 0.05). There were no significant differences (P > 0.05) between ANSB714 treatments and non-ANSB714 treatments on above parameters of mice. Adding ANSB714 to toxic diets could normalize deviant physiological effects of DON on mice.
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ji
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Rong
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
authors.forename: Shujing
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
authors.forename: Jianyun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China. Electronic address: maqiugang@cau.edu.cn.
authors.forename: Qiugang
authors.initials: Q
authors.lastname: Ma
mesh_terms: D000821:Animal Feed; D000818:Animals; D001774:Blood Chemical Analysis; D004032:Diet; D005506:Food Contamination / Q000032:analysis / Q000517:prevention & control*; D005670:Fusarium / Q000502:physiology*; D007107:Immune System / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000254:growth & development* / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D059551:Toxicity Tests, Subacute / Q000379:methods*; D014255:Trichothecenes / Q000633:toxicity*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014255:Trichothecenes; D014409:Tumor Necrosis Factor-alpha; C007262:deoxynivalenol
keywords: Biological transformation; Deoxynivalenol; Devosia sp. ANSB714; Growth performance; Residues; Serum chemistry and immunity function