title: Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet-Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates.
abstract: An inter- as well as intra-molecular thia-Pictet-Spengler cyclization of N-tethered thiols and vinylogous thiocarbonates is described for the stereoselective synthesis of N-fused thiazinoindole derivatives. The strategy is extended to one-pot, sequential Friedel-Crafts alkylation - Pictet-Spengler cyclization and the synthesis of thiazino-oxepino-indole.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai - 400076, India. sjgharpure@iitb.ac.in.
authors.forename: Santosh J
authors.initials: SJ
authors.lastname: Gharpure
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Nanda