title: First Two Cases of Fungal Infections Associated with Multi-drug Resistant Yeast, Fereydounia khargensis.
abstract: The number of new fungal pathogens is increasing due to growing population of immunocompromised patients and advanced identification techniques. Fereydounia khargensis is a yeast and was first described in 2014 from environmental samples. As far as we know, this is the first report of human infections associated with F. khargensis. The yeasts were isolated from blood of a HIV-positive patient and pleural fluid of chronic renal failure patient. Amplification and sequencing of the internal transcribed spacer and the large subunit regions confirmed the identity of the isolates. Both isolates showed multi-drug resistance to antifungal agents tested.
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia. ratna@imr.gov.my.
authors.forename: Ratna Mohd
authors.initials: RM
authors.lastname: Tap
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Nur Yasmin
authors.initials: NY
authors.lastname: Ramli
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Parameswari
authors.initials: P
authors.lastname: Sabaratnam
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Rohaidah
authors.initials: R
authors.lastname: Hashim
authors.affiliation: Microbiology Unit, Pathology Department, Queen Elizabeth Hospital, 88200, Kota Kinabalu, Sabah, Malaysia.
authors.forename: Ahmed Rafezzan Ahmed
authors.initials: AR
authors.lastname: Bakri
authors.affiliation: Microbiology Unit, Pathology Department, Sultanah Fatimah Specialist Hospital, 84000, Muar, Johor, Malaysia.
authors.forename: Lim Bee
authors.initials: LB
authors.lastname: Bee
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Stephanie Jane
authors.initials: SJ
authors.lastname: Ginsapu
authors.affiliation: Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, 50588, Malaysia.
authors.forename: Rahimah
authors.initials: R
authors.lastname: Ahmad
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Mohd Fuat Abd
authors.initials: MF
authors.lastname: Razak
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Norazah
authors.initials: N
authors.lastname: Ahmad
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology; D001487:Basidiomycota / Q000187:drug effects* / Q000302:isolation & purification*; D001769:Blood / Q000382:microbiology; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D026141:Drug Resistance, Multiple, Fungal; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008828:Microbiological Techniques; D008853:Microscopy; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D010996:Pleural Effusion / Q000382:microbiology; D051437:Renal Insufficiency / Q000150:complications; D017422:Sequence Analysis, DNA
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer
keywords: Fereydounia khargensis; Multi-drug resistance; Urocystidales; Ustilaginomycotina