title: Acne-Like Subcutaneous Phaeohyphomycosis Caused by Cladosporium cladosporioides: A Rare Case Report and Review of Published Literatures.
abstract: We report a rare case of subcutaneous phaeohyphomycosis caused by Cladosporium cladosporioides. A 21-year-old man was presented to our clinic with the history of cysts and nodules on his face and neck for 5 years. He was diagnosed subcutaneous phaeohyphomycosis according to the finding of fungal elements in histopathological examination and direct microscopic examination of cyst pus, which was confirmed by positive culture of the cyst pus. The isolate grown on culture was identified as C. cladosporioides on the basis of morphological characters and sequence of the ITS region of ribosomal DNA. After treatment with oral itraconazole, he almost completely resolved the inflammatory lesions. To the best of our knowledge, this is the first case report of C. cladosporioides infection presented with multiple cysts and nodules like acne.
authors.affiliation: Department of Dermatology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
authors.forename: Ya Bin
authors.initials: YB
authors.lastname: Zhou
authors.affiliation: Department of Dermatology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
authors.forename: Ting Ting
authors.initials: TT
authors.lastname: Sun
authors.affiliation: Department of Dermatology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
authors.forename: Xing Jia
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China. lidm3@163.com.
authors.forename: Dong Ming
authors.initials: DM
authors.lastname: Li
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002963:Cladosporium / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D006651:Histocytochemistry; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008853:Microscopy; D060446:Phaeohyphomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D017422:Sequence Analysis, DNA; D012867:Skin / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D017964:Itraconazole
keywords: Acne; Cladosporium cladosporioides; Fungus; Phaeohyphomycosis