title: Association of Plasma Aβ40 Peptides, But Not Aβ42, with Coronary Artery Disease and Diabetes Mellitus.
abstract: Plasma levels of amyloid-beta (Aβ) 1-40 peptide have been proposed to be associated with cardiovascular mortality in patients with coronary artery disease (CAD). Therefore, we aimed to investigate the association of plasma Aβ levels with CAD, cardiovascular risk factors (CVRF), and APOE genotype in non-demented elderly individuals.
  
  
  
  Plasma Aβ1 - 40 and Aβ1 - 42 levels of 526 individuals (mean age of 63.0±7.3 years) were quantified with the INNO-BIA plasma Aβ forms assay based on multiplextrademark technique. APOE genotype was determined with an established protocol. Presence of CAD and CVRFs were ascertained using a questionnaire and/or medical records.
  
  
  
  Plasma Aβ1 - 40 levels were significantly higher in individuals with CAD (p = 0.043) and, independently, in individuals with diabetes mellitus (DM) type 2 (p = 0.001) while accounting for age- and gender-effects. Plasma Aβ1 - 42 levels were higher in APOEɛ4 carriers (p = 0.004), but were neither relevantly associated with CAD nor with any CVRF. Plasma Aβ1 - 40 showed no association with APOE genotype.
  
  
  
  Our findings argue for an association of circulating plasma Aβ1 - 40 peptides with incident CAD and DM. Further investigations are needed to entangle the role of Aβ1 - 40 role in the pathophysiology of cardiovascular disease independent of its known role in Alzheimer's disease.
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Roeben
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.|Geriatric Center, University of Tübingen, Tübingen, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.affiliation: Key4AD, Eke, Belgium.|Innogenetics N.V. (now Fujirebio Europe N.V.), Ghent, Belgium.
authors.forename: Eugeen
authors.initials: E
authors.lastname: Vanmechelen
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Schulte
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Heinzel
authors.affiliation: Institute of Cardiovascular Regeneration, Centre of Molecular Medicine, J.W. Goethe University Frankfurt, Frankfurt am Main, Germany.|Department of Cardiology, J.W. Goethe University Frankfurt, Frankfurt am Main, Germany.|German Center of Cardiovascular Research (DZHK), Frankfurt, Germany.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Stellos
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Godau
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.|Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
authors.forename: Heiko
authors.initials: H
authors.lastname: Huber
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Brockmann
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Isabel
authors.initials: I
authors.lastname: Wurster
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gaenslen
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Grüner
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.|Geriatric Center, University of Tübingen, Tübingen, Germany.
authors.forename: Raphael
authors.initials: R
authors.lastname: Niebler
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.|Geriatric Center, University of Tübingen, Tübingen, Germany.
authors.forename: Gerhard W
authors.initials: GW
authors.lastname: Eschweiler
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000097:blood*; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000235:genetics; D003920:Diabetes Mellitus / Q000097:blood* / Q000235:genetics; D005260:Female; D060005:Genotyping Techniques; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D015415:Biomarkers; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)
keywords: APOE genotype; Alzheimer’s disease; amyloid-beta; coronary artery disease; diabetes mellitus; vascular