title: Effects of Astaxanthin from Litopenaeus Vannamei on Carrageenan-Induced Edema and Pain Behavior in Mice.
abstract: Carrageenan produces both inflammation and pain when injected in mouse paws via enhancement of reactive oxygen species formation. We have investigated an effect of astaxanthin extracted from Litopenaeus vannamei in carrageenan-induced mice paw edema and pain. The current study demonstrates interesting effects from astaxanthin treatment in mice: an inhibition of paw edema induced in hind paw, an increase in mechanical paw withdrawal threshold and thermal paw withdrawal latency, and a reduction in the amount of myeloperoxidase enzyme and lipid peroxidation products in the paw. Furthermore the effect was comparable to indomethacin, a standard treatment for inflammation symptoms. Due to adverse effects of indomethacin on cardiovascular and gastrointestinal systems, our study suggests promising prospect of astaxanthin extract as an anti-inflammatory alternative against carrageenan-induced paw edema and pain behavior.
authors.affiliation: Department of Physiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. lee.kuedo@gmail.com.
authors.forename: Zulkiflee
authors.initials: Z
authors.lastname: Kuedo
authors.affiliation: Center for Advanced Studies for Agriculture and Food, Kasetsart University, Bangkok 10900, Thailand. anantita_sw@hotmail.com.
authors.forename: Anantita
authors.initials: A
authors.lastname: Sangsuriyawong
authors.affiliation: Center for Advanced Studies for Agriculture and Food, Kasetsart University, Bangkok 10900, Thailand. ffiswak@ku.ac.th.
authors.forename: Wanwimol
authors.initials: W
authors.lastname: Klaypradit
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand. tvaromya@medicine.psu.ac.th.
authors.forename: Varomyalin
authors.initials: V
authors.lastname: Tipmanee
authors.affiliation: Department of Physiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. pennapa.ch@psu.ac.th.
authors.forename: Pennapa
authors.initials: P
authors.lastname: Chonpathompikunlert
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006614:Hindlimb / Q000187:drug effects / Q000473:pathology; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000473:pathology; D033561:Penaeidae / Q000737:chemistry; D024341:Xanthophylls / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D024341:Xanthophylls; C005948:astaxanthine; D002351:Carrageenan
keywords: Litopenaeus vannamei; astaxanthin; carrageenan; inflammatory pain; mice; myeloperoxidase