title: A Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/07_BC) Among Heterosexuals in Nei Monggoi Autonomous Region in China.
abstract: Increasing second-generation recombinant forms (CRF01_AE/07_BC) have been detected in China recently. Here, we isolated a novel CRF01_AE/07_BC second-generation recombinant form in HIV-1-positive Nei Monggoi's heterosexuals with one CRF07_BC inserted into the CRF01_AE backbone. Polygenetic analyses showed that the CRF01_AE region was grouped with the previously reported cluster 5 lineage, which spreads among the sexual population in north of China, inferring that this recombinant event occurred through heterosexual contact in the north of China possibly. The growing emergence of recombinant forms means coexistence of multiple strains and complexity of the HIV-1 epidemic, which reminds us of the urgent necessity to focus the HIV surveillance among the high-risk populations nationwide in China, particularly to enhance preventive measures in HIV-1 low-prevalence areas.
authors.affiliation: 1 Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China .
authors.forename: Minghui
authors.initials: M
authors.lastname: An
authors.affiliation: 1 Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China .
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Han
authors.affiliation: 1 Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China .
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.affiliation: 1 Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China .
authors.forename: Junjie
authors.initials: J
authors.lastname: Xu
authors.affiliation: 1 Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China .
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Chu
authors.affiliation: 1 Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China .|2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Hangzhou, People's Republic of China .
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D020010:Heterosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D062486:Public Health Surveillance; D011995:Recombination, Genetic