title: Altered Resting-State Amygdala Functional Connectivity after Real-Time fMRI Emotion Self-Regulation Training.
abstract: Real-time fMRI neurofeedback (rtfMRI-nf) is a promising tool for enhancing emotion regulation capability of subjects and for the potential alleviation of neuropsychiatric disorders. The amygdala is composed of structurally and functionally distinct nuclei, such as the basolateral amygdala (BLA) and centromedial amygdala (CMA), both of which are involved in emotion processing, generation, and regulation. However, the effect of rtfMRI-nf on the resting-state functional connectivity (rsFC) of BLA and CMA remains to be elucidated. In our study, participants were provided with ongoing information on their emotion states by using real-time multivariate voxel pattern analysis. Results showed that participants presented significantly increased rsFC of BLA and CMA with prefrontal cortex, rostral anterior cingulate cortex, and some others related to emotion after rtfMRI-nf training. The findings provide important evidence for the emotion regulation effectiveness of rtfMRI-nf training and indicate its usefulness as a tool for the self-regulation of emotion.
authors.affiliation: China National Digital Switching System Engineering and Technological Research Center, Zhengzhou, Henan 450000, China.
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Li
authors.affiliation: China National Digital Switching System Engineering and Technological Research Center, Zhengzhou, Henan 450000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tong
authors.affiliation: Department of Radiology, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
authors.forename: Min
authors.initials: M
authors.lastname: Guan
authors.affiliation: China National Digital Switching System Engineering and Technological Research Center, Zhengzhou, Henan 450000, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: He
authors.affiliation: China National Digital Switching System Engineering and Technological Research Center, Zhengzhou, Henan 450000, China.
authors.forename: Linyuan
authors.initials: L
authors.lastname: Wang
authors.affiliation: China National Digital Switching System Engineering and Technological Research Center, Zhengzhou, Henan 450000, China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Bu
authors.affiliation: Department of Radiology, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Shi
authors.affiliation: China National Digital Switching System Engineering and Technological Research Center, Zhengzhou, Henan 450000, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yan
mesh_terms: D000328:Adult; D000679:Amygdala / Q000000981:diagnostic imaging / Q000502:physiology; D063132:Connectome; D000066498:Emotional Adjustment / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012146:Rest / Q000502:physiology*