title: The Effect of Systemic and Regional Use of Magnesium Sulfate on Postoperative Tramadol Consumption in Lumbar Disc Surgery.
abstract: OBJECTIVE
  To investigate the effect of magnesium administered to the operative region muscle and administered systemically on postoperative analgesia consumption after lumbar disc surgery.
  
  
  METHODS
  The study included a total of 75 ASA I-II patients aged 18-65 years. The patients were randomly allocated into 1 of 3 groups of 25: the Intravenous (IV) Group, the Intramuscular (IM) Group, and the Control (C) Group. At the stage of suturing the surgical incision site, the IV Group received 50 mg/kg MgSO4 intravenously in 150 mL saline within 30 mins. In the IM Group, 50 mg/kg MgSO4 in 30 mL saline was injected intramuscularly into the paraspinal muscles. In Group C, 30 mL saline was injected intramuscularly into the paraspinal muscles. After operation patients in all 3 groups were given 100 mg tramadol and 10 mg metoclopramide and tramadol solution was started intravenously through a patient-controlled analgesia device. Hemodynamic changes, demographic data, duration of anesthesia and surgery, pain scores (NRS), the Ramsay sedation score (RSS), the amount of analgesia consumed, nausea- vomiting, and potential side effects were recorded.
  
  
  RESULTS
  No difference was observed between the groups. Nausea and vomiting side effects occurred at a rate of 36% in Group C, which was a significantly higher rate compared to the other groups (p < 0.05). Tramadol consumption in the IM Group was found to be significantly lower than in the other groups (p < 0.05).
  
  
  CONCLUSIONS
  Magnesium applied to the operative region was found to be more effective on postoperative analgesia than systemically administered magnesium.
authors.affiliation: Ankara Numune Training and Research Hospital, Anesthesiology Department, Ankara, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Demiroglu
authors.affiliation: Ankara Numune Training and Research Hospital, Anesthesiology Department, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Ün
authors.affiliation: Ankara Numune Training and Research Hospital, Anesthesiology Department, Ankara, Turkey.
authors.forename: Dilsen Hatice
authors.initials: DH
authors.lastname: Ornek
authors.affiliation: Ankara Numune Training and Research Hospital, Anesthesiology Department, Ankara, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Kıcı
authors.affiliation: Ankara Numune Training and Research Hospital, Neurosurgery Department, Ankara, Turkey.
authors.forename: Ali Erdem
authors.initials: AE
authors.lastname: Yıldırım
authors.affiliation: Ankara Yıldırım Beyazit University Medical School Anesthesiology Department, Ankara, Turkey.
authors.forename: Eyup
authors.initials: E
authors.lastname: Horasanlı
authors.affiliation: Ankara Numune Training and Research Hospital, Anesthesiology Department, Ankara, Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Başkan
authors.affiliation: Ankara Numune Training and Research Hospital, Anesthesiology Department, Ankara, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Fikir
authors.affiliation: Ankara Numune Training and Research Hospital, Anesthesiology Department, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gamli
authors.affiliation: Ankara Gazi University Medical School Anesthesiology Department, Ankara, Turkey.
authors.forename: Bayazit
authors.initials: B
authors.lastname: Dikmen
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000601:surgery; D010149:Postoperative Pain / Q000188:drug therapy*; D011182:Postoperative Care / Q000379:methods*; D014147:Tramadol / Q000008:administration & dosage*
chemical_list: D014147:Tramadol; D008278:Magnesium Sulfate