title: The IL-1 cytokine family and its role in inflammation and fibrosis in the lung.
abstract: The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 targeted therapies have been successfully employed to treat a range of inflammatory conditions such as rheumatoid arthritis and gouty arthritis. This review will introduce the members of the IL-1 cytokine family, briefly discuss the cellular origins and cellular targets and provide an overview of the role of these molecules in inflammation and fibrosis in the lung.
authors.affiliation: Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor, William Leech Building, Newcastle upon Tyne, NE2 4HH, UK. lee.borthwick@newcastle.ac.uk.
authors.forename: L A
authors.initials: LA
authors.lastname: Borthwick
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism*; D008171:Lung Diseases / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007375:Interleukin-1; D017472:Receptors, Interleukin-1
keywords: Fibroblast; Fibrosis; IL-1; IL-18; IL-33; Inflammation; Lung