title: Role of fine-needle aspiration cytology and core needle biopsy in diagnosing musculoskeletal neoplasms.
abstract: BACKGROUND
  The management of musculoskeletal neoplasms requires an accurate diagnosis, histologic type, and degree of tumor differentiation.
  
  
  OBJECTIVE
  The present study was undertaken to compare the accuracy of fine-needle aspiration cytology (FNAC) and core needle biopsy (CNB) in the diagnosis of musculoskeletal tumors and further to compare the results with histopathological examination of surgical specimens. Grading of malignant tumors was also compared on these techniques.
  
  
  METHODS
  This prospective study was conducted on 50 patients with musculoskeletal neoplasms. Detailed history, clinical examination, and radiological investigations were undertaken. FNAC followed by CNB were performed in each case. The tumors were categorized as benign and malignant with a definitive histotype diagnosis. For malignant neoplasms, cytologic and histologic gradings were done into three grades. The sensitivity and specificity of FNAC and CNB were compared.
  
  
  RESULTS
  Of the 50 cases with musculoskeletal neoplasms, 32 (64%) were bone tumors and 18 (36%) were soft tissue tumors. The sensitivity of FNAC and CNB for categorizing bone tumors into benign and malignant was 94.7%. For soft tissue tumors, FNAC had a sensitivity of 90.9% and CNB had a sensitivity of 100%. The specificity of both the techniques, FNA and CNB for bone and soft tissue tumors was 100%. For malignant bone tumors, cytologic grade was concordant with CNB grade in 72.2% of the cases. Cytologic grade was concordant with the grade on CNB in 81.8% cases for malignant soft tissue neoplasms.
  
  
  CONCLUSIONS
  FNAC and CNB alleviate the need for an open biopsy in diagnosing and grading musculoskeletal neoplasms, thus facilitating appropriate therapeutic intervention.
authors.affiliation: Department of Pathology, Government Medical College and Hospital, Chandigarh, Punjab and Haryana, India.
authors.forename: Ivreet
authors.initials: I
authors.lastname: Kaur
authors.affiliation: Department of Pathology, Government Medical College and Hospital, Chandigarh, Punjab and Haryana, India.
authors.forename: Uma
authors.initials: U
authors.lastname: Handa
authors.affiliation: Department of Pathology, Government Medical College and Hospital, Chandigarh, Punjab and Haryana, India.
authors.forename: Reetu
authors.initials: R
authors.lastname: Kundu
authors.affiliation: Department of Orthopaedics, Government Medical College and Hospital, Chandigarh, Punjab and Haryana, India.
authors.forename: Sudhir Kumar
authors.initials: SK
authors.lastname: Garg
authors.affiliation: Department of Pathology, Government Medical College and Hospital, Chandigarh, Punjab and Haryana, India.
authors.forename: Harsh
authors.initials: H
authors.lastname: Mohan
keywords: Bone; core needle biopsy (CNB); fine-needle aspiration (FNA); histopathology; neoplasm; soft tissue