title: Comparison of impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate and phenobarbital.
abstract: OBJECTIVE
  To study the impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate (TPM) and phenobarbital (PB).
  
  
  METHODS
  Two hundred cases children with epilepsy from August 2010 to August 2013 in our hospital were sampled and randomly divided into two groups. The observation group was treated with TPM while the control group with PB, and then comparing seizure frequency, efficiency, and adverse reactions of two groups.
  
  
  RESULTS
  The reduced number of partial seizures, generalized seizures, and total seizures in the observation group were significantly higher than those in the control group, and the rate of cure, markedly effective and total efficiency in observation group were significantly higher than those in the control group. However, the adverse reactions in observation group were significantly lower than those in the control group. Thus, differences were statistically significant (p<0.05).
  
  
  CONCLUSIONS
  Compared with PB, TPM showed a better effect on epilepsy treatment with less adverse reactions which were worthy of clinical recommendation.
authors.affiliation: Department of Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R. China. dengxingqiang1962@163.com.
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Wang
authors.forename: M-G
authors.initials: MG
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Yao
authors.forename: X-X
authors.initials: XX
authors.lastname: Huang
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Deng
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects / Q000627:therapeutic use*; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D010634:Phenobarbital