title: Vitamin D for the treatment of painful diabetic neuropathy.
abstract: OBJECTIVE
  To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.
  
  
  METHODS
  A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.
  
  
  RESULTS
  143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).
  
  
  CONCLUSIONS
  Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.
  
  
  BACKGROUND
  BIDE-12/2014.
authors.affiliation: Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan; Baqai Medical University, Karachi, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Basit
authors.affiliation: Baqai Institute of Diabetology and Endocrinology , Karachi , Pakistan.
authors.forename: Khalid Abdul
authors.initials: KA
authors.lastname: Basit
authors.affiliation: Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan; Baqai Medical University, Karachi, Pakistan.
authors.forename: Asher
authors.initials: A
authors.lastname: Fawwad
authors.affiliation: Baqai Institute of Diabetology and Endocrinology , Karachi , Pakistan.
authors.forename: Fariha
authors.initials: F
authors.lastname: Shaheen
authors.affiliation: Baqai Institute of Diabetology and Endocrinology , Karachi , Pakistan.
authors.forename: Nimra
authors.initials: N
authors.lastname: Fatima
authors.affiliation: Weill Cornell Medicine-Qatar, Qatar Foundation , Doha , Qatar.
authors.forename: Ioannis N
authors.initials: IN
authors.lastname: Petropoulos
authors.affiliation: Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust , Manchester , UK.
authors.forename: Uazman
authors.initials: U
authors.lastname: Alam
authors.affiliation: Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar; Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, UK.
authors.forename: Rayaz A
authors.initials: RA
authors.lastname: Malik
keywords: Neuropathy Complications; Neuropathy and Clinical Diabetes; Pain; Vitamin D