title: New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression.
abstract: Regulatory B (Breg) cells are important regulators of immune responses and in recent years our understanding of their phenotypical and functional characteristics has improved considerably. Initially all suppressive capabilities of Breg cells were attributed to the actions of the anti-inflammatory cytokine interleukin (IL)-10 secreted by Breg cells. Recent studies however, highlight additional and novel mechanisms that influence both the expansion of Breg cells and their capacity to suppress immunity. Here we provide an overview of the complexity of Breg cell populations and address the newly discovered IL-10 independent mechanisms of Breg cell expansion and immune-suppression.
authors.affiliation: School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.|National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland.
authors.forename: Achilleas
authors.initials: A
authors.lastname: Floudas
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Amu
authors.affiliation: School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. pfallon@tcd.ie.|National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland. pfallon@tcd.ie.
authors.forename: Padraic G
authors.initials: PG
authors.lastname: Fallon
mesh_terms: D000818:Animals; D060151:B-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism*; D002450:Cell Communication; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D056747:Immunomodulation; D007165:Immunosuppression Therapy; D007167:Immunotherapy / Q000379:methods; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism*; D008212:Lymphocyte Depletion; D051379:Mice; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D016753:Interleukin-10
keywords: B cells; IL-10; inflammation; regulatory B cells