title: Objective Level of Alertness and Inhibitory Control Predict Highway Driving Impairment in Adults With ADHD.
abstract: Objective:It remains unclear whether daytime impairments in ADHD patients are better explained by an altered level of alertness and/or by cognitive deficits. The aim of this study was to determine the respective contribution of these factors on driving performance in ADHD adults.Method:ADHD adults (n= 39) and healthy controls (n= 18) underwent a nocturnal polysomnography (PSG) followed by a Maintenance of Wakefulness Test (MWT), a simulated driving task, and a neuropsychological evaluation.Results:ADHD patients had shorter mean sleep latency on the MWT and worse driving performance than controls. They also made more errors on attention and executive functioning tests. Logistic regression analyses showed that inhibition deficits and objective daytime sleepiness predicted highway driving performance in ADHD.Conclusion:Our study shows that not only inhibitory control deficits but also pathological level of alertness independently contribute to highway driving impairment in ADHD patients, providing a better understanding of the pathophysiological mechanisms involved in ADHD.
authors.affiliation: Pôle Universitaire Psychiatrie Enfants et Adolescents, Bordeaux, France.|Université de Bordeaux, France.|Unité de Service et de Recherche du Centre National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et Neuropsychiatrie (SANPSY), Bordeaux, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bioulac
authors.affiliation: Université de Bordeaux, France.|Unité de Service et de Recherche du Centre National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et Neuropsychiatrie (SANPSY), Bordeaux, France.|Centre Hospitalier Universitaire (CHU) Pellegrin, Clinique du Sommeil, Bordeaux, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Sagaspe
authors.affiliation: Université de Bordeaux, France.|Unité de Service et de Recherche du Centre National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et Neuropsychiatrie (SANPSY), Bordeaux, France.|Centre Hospitalier Universitaire (CHU) Pellegrin, Clinique du Sommeil, Bordeaux, France.
authors.forename: Jean-Arthur
authors.initials: JA
authors.lastname: Micoulaud-Franchi
authors.affiliation: Université de Bordeaux, France.|Unité de Service et de Recherche du Centre National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et Neuropsychiatrie (SANPSY), Bordeaux, France.
authors.forename: Ellemarije
authors.initials: E
authors.lastname: Altena
authors.affiliation: Université de Bordeaux, France.|Unité de Service et de Recherche du Centre National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et Neuropsychiatrie (SANPSY), Bordeaux, France.|Centre Hospitalier Universitaire (CHU) Pellegrin, Clinique du Sommeil, Bordeaux, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Taillard
authors.affiliation: University of Strasbourg, France.|Institute for Cellular and Integrative Neuroscience, Strasbourg, France.
authors.forename: Carmen
authors.initials: C
authors.lastname: Schröder
authors.affiliation: Pôle Universitaire Psychiatrie Enfants et Adolescents, Bordeaux, France.
authors.forename: Manuel-Pierre
authors.initials: MP
authors.lastname: Bouvard
authors.affiliation: Université de Bordeaux, France.|Unité de Service et de Recherche du Centre National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et Neuropsychiatrie (SANPSY), Bordeaux, France.
authors.forename: Colette
authors.initials: C
authors.lastname: Fabrigoule
authors.affiliation: Université de Bordeaux, France.|Unité de Service et de Recherche du Centre National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et Neuropsychiatrie (SANPSY), Bordeaux, France.|Centre Hospitalier Universitaire (CHU) Pellegrin, Clinique du Sommeil, Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Philip
mesh_terms: D000328:Adult; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity; D001334:Automobile Driving; D006970:Disorders of Excessive Somnolence; D006801:Humans; D017286:Polysomnography; D014851:Wakefulness
keywords: ADHD; executive function; inhibition; objective daytime sleepiness; simulator driving