title: Prenatal exposure to bisphenol A disrupts adrenal steroidogenesis in adult mouse offspring.
abstract: The present study sought to determine if prenatal exposure to bisphenol A (BPA) alters adrenal steroidogenesis in adult offspring. Pregnant mice were exposed to BPA (25mg BPA/kg food pellet) via diet from day 7 to the end of pregnancy. At eight weeks of age, offsprings were sacrificed, blood samples and adrenal glands were collected for hormone assays and western blot analysis, respectively. We found that: (1) BPA increased adrenal gland weight in both males and females; (2) although BPA elevated plasma corticosterone levels in both sexes, it stimulated the expression of StAR and cyp11A1, the two rate-limiting factors in the steroidogenic pathway, only in female adrenal glands; and interestingly (3) BPA did not alter plasma ACTH levels or adrenal expression of the key steroidogenic transcription factor SF-1 in either sex. Taken together, the present study provides novel insights into the long-term consequences of developmental BPA exposure on adrenal steroidogenesis.
authors.affiliation: Children's Health Research Institute & Lawson Health Research Institute, Departments of Obstetrics & Gynaecology and Physiology & Pharmacology, Western University, 800 Commissioners Rd. E., London, Ontario N6C 2V5, Canada.
authors.forename: Samantha
authors.initials: S
authors.lastname: Medwid
authors.affiliation: Children's Health Research Institute & Lawson Health Research Institute, Departments of Obstetrics & Gynaecology and Physiology & Pharmacology, Western University, 800 Commissioners Rd. E., London, Ontario N6C 2V5, Canada.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Guan
authors.affiliation: Children's Health Research Institute & Lawson Health Research Institute, Departments of Obstetrics & Gynaecology and Physiology & Pharmacology, Western University, 800 Commissioners Rd. E., London, Ontario N6C 2V5, Canada. Electronic address: kyang@uwo.ca.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Yang
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013256:Steroids / Q000378:metabolism*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D013256:Steroids; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Adrenal gland; Bisphenol A; Developmental exposure; Steroidogenesis