title: Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long-lasting changes in language organization.
abstract: Sophisticated neuroimaging strategies demonstrate alterations in functional connectivity at school age, adolescence, and young adulthood in individuals born preterm. Recent data suggest these alterations are present in the postnatal period prior to term-equivalent age in neonates born preterm. Likewise, functional organization increases across development, but the influence of preterm birth on this fundamental infrastructure is immediate and unchanging. This article briefly reviews the current methods of measuring functional connectivity throughout development in those born preterm, and the association of functional connectivity with language disorders. Taken together, these data suggest that the effects of preterm birth on the functional organization of language in the developing brain are both proximate and long-lasting.
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Kwon
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Dustin
authors.initials: D
authors.lastname: Scheinost
authors.affiliation: Warren Alpert Brown Medical School, Providence, RI, USA.
authors.forename: Betty
authors.initials: B
authors.lastname: Vohr
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Lacadie
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Schneider
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Dai
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Gordon
authors.initials: G
authors.lastname: Sze
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.|Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: R Todd
authors.initials: RT
authors.lastname: Constable
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.|Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Laura R
authors.initials: LR
authors.lastname: Ment
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006803:Human Development / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055815:Young Adult