title: Hyperuricemia and Cardiovascular Disease in Patients with Hypertension.
abstract: BACKGROUND
  Little is known about the role of serum uric acid in cardiovascular events. We studied the prevalence of hyperuricemia and the association between uric acid level and various cardiovascular risk factors.
  
  
  METHODS
  This cross-sectional study was based on a population of patients with hypertension who attended a hypertension clinic in a university hospital in Bogotá, Colombia. Bivariate analysis and multivariate logistic regression models were utilized to investigate the relationship between hyperuricemia and cardiovascular risk factors.
  
  
  RESULTS
  The study population included 444 patients. The overall prevalence of hyperuricemia was 28.8%. Male gender (OR 2.3), age (OR 1.03), BMI (OR 1.09), triglyceride level (OR 1.005) and low HDL (OR 0.96) were significantly associated with hyperuricemia.
  
  
  CONCLUSIONS
  Prevalence of hyperuricemia is high in patients with hypertension. Serum uric acid is significantly associated with parameters of the metabolic syndrome. Hyperuricemia should be acknowledged and monitored as a risk factor for cardiovascular disease.
authors.forename: Andres
authors.initials: A
authors.lastname: Acevedo
authors.forename: Julian
authors.initials: J
authors.lastname: Benavides
authors.forename: Mohsin
authors.initials: M
authors.lastname: Chowdhury
authors.forename: Mabel
authors.initials: M
authors.lastname: Lopez
authors.forename: Laura
authors.initials: L
authors.lastname: Pena
authors.forename: Ana
authors.initials: A
authors.lastname: Montenegro
authors.forename: Marta
authors.initials: M
authors.lastname: Lievano
authors.forename: Bernardo
authors.initials: B
authors.lastname: Lombo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D003105:Colombia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D033461:Hyperuricemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014280:Triglycerides / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides; D014527:Uric Acid