title: Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp3)-H bonds.
abstract: The first nickel catalyzed deprotonative cross coupling between C(sp3)-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.
authors.affiliation: EaStCHEM School of Chemistry , University of St Andrews , St Andrews , KY16 9ST , UK . Email: stevenpnolan@gmail.com.
authors.forename: José A
authors.initials: JA
authors.lastname: Fernández-Salas
authors.affiliation: EaStCHEM School of Chemistry , University of St Andrews , St Andrews , KY16 9ST , UK . Email: stevenpnolan@gmail.com.
authors.forename: Enrico
authors.initials: E
authors.lastname: Marelli
authors.affiliation: EaStCHEM School of Chemistry , University of St Andrews , St Andrews , KY16 9ST , UK . Email: stevenpnolan@gmail.com; Chemistry Department , College of Science , King Saud University , Riyadh 11451 , Saudi Arabia.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Nolan