title: [From dualism to multiplicity: seeing BCL-2 family proteins and cell death with new eyes].
abstract: The concept of cell death has many links to the concept of death itself, defined as the opposite of life. Achievements obtained through research on apoptosis have apparently allowed us to transcend this Manichean view. Death is no longer outside, but rather inside living systems, as a constitutive force at work within the living matter. Whereas the death of cells can be positive and breed "creation" (e.g. during morphogenesis), its dysregulation can also cause or contribute to fatal diseases including cancer. It is tempting to apply this biological discourse to illuminate the relations between life and death, taken in general terms, but does this generalization actually hold? Is this discourse not essentially a metaphor? If cell death is considered as a vital aspect of various biological processes, then are we not faced with some vitalistic conception of death? Are there one or more meanings to the word "death"? Does the power to self-destruct act in opposition to other key features of living entities, or rather in juxtaposition to them? In this article, we first describe how the field of cell death has been developed on the basis of perceived and built dichotomies, mirroring the original opposition between life and death. We detail the limitations of the current paradigm of apoptosis regulation by BCL-2 family proteins, which nicely illustrate the problem of binary thinking in biology. Last, we try to show a way out of this dualistic matrix, by drawing on the notions of multiplicity, complexity, diversity, evolution and contingency.
authors.affiliation: LBMC - Laboratoire de Biologie Moléculaire de la Cellule, École Normale Supérieure de Lyon, UMR 5239, CNRS, Université Lyon 1, HCL, 46 Allée d'Italie, 69364 Lyon Cedex 07, France - ISEM - Institut des Sciences de l'Évolution de Montpellier, UMR 5554, Université de Montpellier, CNRS, IRD, EPHE, Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: Abdel
authors.initials: A
authors.lastname: Aouacheria
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016923:Cell Death / Q000502:physiology*; D019143:Evolution, Molecular; D006801:Humans; D008958:Models, Molecular; D009024:Morphogenesis; D009369:Neoplasms; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000502:physiology*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2