title: Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities.
abstract: Anthraquinones and their derivatives constitute a large group of quinoid compounds with about 700 molecules described. They are widespread in fungi and their chemical diversity and biological activities recently attracted attention of industries in such fields as pharmaceuticals, clothes dyeing, and food colorants. Their positive and/or negative effect(s) due to the 9,10-anthracenedione structure and its substituents are still not clearly understood and their potential roles or effects on human health are today strongly discussed among scientists. As marine microorganisms recently appeared as producers of an astonishing variety of structurally unique secondary metabolites, they may represent a promising resource for identifying new candidates for therapeutic drugs or daily additives. Within this review, we investigate the present knowledge about the anthraquinones and derivatives listed to date from marine-derived filamentous fungi's productions. This overview highlights the molecules which have been identified in microorganisms for the first time. The structures and colors of the anthraquinoid compounds come along with the known roles of some molecules in the life of the organisms. Some specific biological activities are also described. This may help to open doors towards innovative natural substances.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments-LCSNSA EA 2212, Université de la Réunion, 15 Avenue René Cassin, CS 92003, F-97744 Saint-Denis Cedex 9, Ile de la Réunion, France. mireille.fouillaud@univ-reunion.fr.|Ecole Supérieure d'Ingénieurs Réunion Océan Indien-ESIROI, 2 Rue Joseph Wetzell, F-97490 Sainte-Clotilde, Ile de la Réunion, France. mireille.fouillaud@univ-reunion.fr.
authors.forename: Mireille
authors.initials: M
authors.lastname: Fouillaud
authors.affiliation: Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments-LCSNSA EA 2212, Université de la Réunion, 15 Avenue René Cassin, CS 92003, F-97744 Saint-Denis Cedex 9, Ile de la Réunion, France. mekalavenkat@gmail.com.
authors.forename: Mekala
authors.initials: M
authors.lastname: Venkatachalam
authors.affiliation: Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments-LCSNSA EA 2212, Université de la Réunion, 15 Avenue René Cassin, CS 92003, F-97744 Saint-Denis Cedex 9, Ile de la Réunion, France. emmanuelle.girard-valenciennes@univ-reunion.fr.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Girard-Valenciennes
authors.affiliation: Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments-LCSNSA EA 2212, Université de la Réunion, 15 Avenue René Cassin, CS 92003, F-97744 Saint-Denis Cedex 9, Ile de la Réunion, France. yanis.caro@univ-reunion.fr.|Ecole Supérieure d'Ingénieurs Réunion Océan Indien-ESIROI, 2 Rue Joseph Wetzell, F-97490 Sainte-Clotilde, Ile de la Réunion, France. yanis.caro@univ-reunion.fr.
authors.forename: Yanis
authors.initials: Y
authors.lastname: Caro
authors.affiliation: Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments-LCSNSA EA 2212, Université de la Réunion, 15 Avenue René Cassin, CS 92003, F-97744 Saint-Denis Cedex 9, Ile de la Réunion, France. laurent.dufosse@univ-reunion.fr.|Ecole Supérieure d'Ingénieurs Réunion Océan Indien-ESIROI, 2 Rue Joseph Wetzell, F-97490 Sainte-Clotilde, Ile de la Réunion, France. laurent.dufosse@univ-reunion.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Dufossé
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000378:metabolism*; D001688:Biological Products / Q000378:metabolism*; D003116:Color; D005658:Fungi / Q000378:metabolism*; D006801:Humans
chemical_list: D000880:Anthraquinones; D001688:Biological Products; C042834:9,10-anthraquinone
keywords: anthraquinone; antibiotic; antitumor; biological activity; cytotoxicity; fungi; marine; pigment