title: Phase-Sensitive Inversion-Recovery MRI Improves Longitudinal Cortical Lesion Detection in Progressive MS.
abstract: Previous studies comparing phase sensitive inversion recovery (PSIR) to double inversion recovery (DIR) have demonstrated that use of PSIR improves cross-sectional in vivo detection of cortical lesions (CL) in multiple sclerosis. We studied the utility of PSIR in detection/characterization of accrual of CL over time in a 1-year longitudinal study in primary progressive multiple sclerosis (PPMS) compared to DIR. PSIR and DIR images were acquired with 3T magnetic resonance imaging (MRI) in 25 patients with PPMS and 19 healthy controls at baseline, and after 1 year in 20 patients with PPMS. CL were classified as intracortical, leucocortical or juxtacortical. Lesion counts and volumes were calculated for both time points from both sequences and compared. Correlations with measures of physical and cognitive disability were determined as well as new CL counts and volumes. Compared to DIR, PSIR led to detection of a higher number of CL involving a larger proportion of patients with PPMS both cross-sectionally (p = 0.006, 88%) and longitudinally (p = 0.007, 95%), and led to the reclassification of a third of CL seen on DIR at each time point. Interestingly, PSIR was more sensitive to new CL accumulation over time compared to DIR. PSIR is a promising technique to monitor cortical damage and disease progression in patients with PPMS over a short-term follow-up.
authors.affiliation: Department of Neurology, Mount Sinai Hospital, New York, New York, United States of America.
authors.forename: Asaff
authors.initials: A
authors.lastname: Harel
authors.affiliation: Department of Neurology, Mount Sinai Hospital, New York, New York, United States of America.
authors.forename: Antonia
authors.initials: A
authors.lastname: Ceccarelli
authors.affiliation: Department of Neurology, Mount Sinai Hospital, New York, New York, United States of America.|Corinne Goldsmith Dickinson Center for MS, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors.forename: Colleen
authors.initials: C
authors.lastname: Farrell
authors.affiliation: Department of Neurology, Mount Sinai Hospital, New York, New York, United States of America.|Corinne Goldsmith Dickinson Center for MS, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors.forename: Michelle
authors.initials: M
authors.lastname: Fabian
authors.affiliation: Department of Neurology, New York University, Langone Medical Center, New York, New York, United States of America.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Howard
authors.affiliation: Department of Neurology, The Neurological Institute of New York, Columbia University, New York, New York, United States of America.
authors.forename: Claire
authors.initials: C
authors.lastname: Riley
authors.affiliation: Department of Neurology, Mount Sinai Hospital, New York, New York, United States of America.|Corinne Goldsmith Dickinson Center for MS, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors.forename: Aaron
authors.initials: A
authors.lastname: Miller
authors.affiliation: Department of Neurology, Mount Sinai Hospital, New York, New York, United States of America.|Corinne Goldsmith Dickinson Center for MS, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors.forename: Fred
authors.initials: F
authors.lastname: Lublin
authors.affiliation: Department of Neurology, Mount Sinai Hospital, New York, New York, United States of America.|Department of Radiology, Mount Sinai Hospital, New York, New York, United States of America.|Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.|Corinne Goldsmith Dickinson Center for MS, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors.forename: Matilde
authors.initials: M
authors.lastname: Inglese
mesh_terms: D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000473:pathology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000473:pathology*; D011446:Prospective Studies