title: Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.
abstract: Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , Imizu, Toyama 939-0398, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , Imizu, Toyama 939-0398, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Asano
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , Imizu, Toyama 939-0398, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Sawamura
authors.affiliation: Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences , Takatsuki, Osaka 569-1041, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: In
authors.affiliation: Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences , Takatsuki, Osaka 569-1041, Japan.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Bioscience and Informatics, Keio University , Yokohama, Kanagawa 223-8522, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Imoto
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D058675:Brevibacillus / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000188:drug therapy; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D000077277:Esophageal Squamous Cell Carcinoma; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera; D053778:Thiazolidines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; D053778:Thiazolidines; C000610010:ulbactin F; C000610011:ulbactin G