title: Risk of bradykinin B2 receptor -58T/C gene polymorphism on hypertension: A meta-analysis.
abstract: The risk of bradykinin B2 receptor (BDKRB2)-58T/C gene polymorphism on hypertension remains controversial. The Cochrane Library, Chinese Biomedical Database, EBSCO, Embase, ISI, MEDLINE, and PubMed were retrieved, and relevant articles were selected. The significant association between BDKRB2 -58T/C gene polymorphism and risk of hypertension were found under C-allele comparison (odds ratio (OR): 1.22, 95% confidential intervals (CI): 1.05-1.42), recessive model (OR: 1.32, 95% CI: 1.07-1.64), dominant model (OR: 0.74, 95% CI: 0.58-0.94), homozygote model (OR: 1.66, 95% CI: 1.11-2.47) and heterozygote model (OR: 1.23, 95% CI: 1.06-1.43). The magnitude of the association between the BDKRB2-58T/C gene polymorphism and risk of hypertension was substantiated in Asians under C-allele comparison (OR: 1.24, 95% CI: 1.04-1.49), recessive model (OR: 1.39, 95% CI: 1.04-1.86), dominant model (OR: 0.72, 95% CI: 0.56-0.93), homozygote model (OR: 1.78, 95% CI: 1.09-2.90) and heterozygote model (OR: 1.26, 95% CI: 1.07-1.49). No publication bias was found in the meta-analysis. The meta-analysis suggested -58C allele and -58CC genotype increase the risk of hypertension in Asians and African-Americans. Inversely, -58TT genotype decreases the risk of hypertension in Asians and African-Americans.
authors.affiliation: Medical Center of the Graduate School, Nanchang University, Nanchang, China.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Luo
authors.affiliation: Medical Center of the Graduate School, Nanchang University, Nanchang, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital, Nanchang University, Nanchang, China.
authors.forename: Gaosi
authors.initials: G
authors.lastname: Xu
mesh_terms: D001794:Blood Pressure / Q000235:genetics*; D016009:Chi-Square Distribution; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D065840:Protective Factors; D044469:Racial Groups; D043782:Receptor, Bradykinin B2 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D043782:Receptor, Bradykinin B2
keywords: bradykinin; genetics; hypertension; kallikrein; meta-analysis