title: Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects.
abstract: BACKGROUND
  The seven 14-3-3 protein isoforms bind to numerous proteins and are involved in a wide variety of cellular events, including the cell cycle, cell division, apoptosis and cancer. We previously found the importance of 14-3-3 proteins in neuronal migration of pyramidal neurons in the developing cortex. Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches.
  
  
  RESULTS
  We found that 14-3-3 proteins are important for the development of neural crest cells, in particular for the pigmentation of the fur on the ventral region of mice.
  
  
  CONCLUSIONS
  Our data obtained from the 14-3-3ε/14-3-3ζ/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages.
authors.affiliation: Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, USA.
authors.forename: Brett
authors.initials: B
authors.lastname: Cornell
authors.affiliation: Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, USA. ktoyooka@drexelmed.edu.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Toyo-oka
mesh_terms: D048948:14-3-3 Proteins / Q000172:deficiency* / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D019465:Craniofacial Abnormalities / Q000473:pathology; D003433:Crosses, Genetic; D005260:Female; D019426:Integrases / Q000378:metabolism*; D008297:Male; D051379:Mice; D009432:Neural Crest / Q000378:metabolism; D010858:Pigmentation / Q000235:genetics*; D011401:Promoter Regions, Genetic; D051155:Wnt1 Protein / Q000378:metabolism*
chemical_list: D048948:14-3-3 Proteins; D019426:Integrases; D051155:Wnt1 Protein; C000590975:Ywhaz protein, mouse; C495246:Wnt1 protein, mouse; C576823:Ywhae protein, mouse; C045073:Cre recombinase
keywords: 14-3-3; Cre transgenic mouse; Knockout mouse; Melanocyte; Neural crest cell; Pigmentation; Weight modulation; White patch; Ywhae; Ywhaz