title: RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2.
abstract: Despite recent increases in the cure rate of acute lymphoblastic leukemia (ALL), adult ALL remains a high-risk disease that exhibits a high relapse rate. In this study, we found that the histone demethylase retinoblastoma binding protein-2 (RBP2) was overexpressed in both on-going and relapse cases of adult ALL, which revealed that RBP2 overexpression was not only involved in the pathogenesis of ALL but that its overexpression might also be related to relapse of the disease. RBP2 knockdown induced apoptosis and attenuated leukemic cell viability. Our results demonstrated that BCL2 is a novel target of RBP2 and supported the notion of RBP2 being a regulator of BCL2 expression via directly binding to its promoter. As the role of RBP2 in regulating apoptosis was confirmed, RBP2 overexpression and activation of BCL2 might play important roles in ALL development and progression.
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Minran
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.affiliation: Anhui Medical College, Hefei, Anhui, P. R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Microbiology/Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Jihui
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Chen
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000235:genetics; D015153:Blotting, Western; D047369:Chromatin Immunoprecipitation; D018450:Disease Progression; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D055785:Gene Knockdown Techniques; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*; D060888:Real-Time Polymerase Chain Reaction; D054840:Retinol-Binding Proteins, Cellular / Q000502:physiology*; D015854:Up-Regulation
chemical_list: C000595707:BCL2 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; C518459:RBP2 protein, human; D054840:Retinol-Binding Proteins, Cellular