title: [Tetraspanins in cutaneous physiopathology].
abstract: Tetraspanins are transmembrane proteins that interact laterally with each other and with different partners such as integrins, immunoglobulin (Ig)-domain-containing proteins, growth factors and cytokine receptors. Such tetraspanin-partner complexes help to organize dynamic membrane networks called "tetraspanin web", which trigger different signalling pathways. Despite the fact that tetraspanins seem abundantly and widely expressed, their function remained unclear. However, it is well established that they control fundamental cellular processes including cell survival, adhesion, migration, invasion or viral infection, but the underlying molecular mechanisms are not well elucidated. This review focuses on tetraspanins that are expressed in epidermis and the roles they play in normal and pathological conditions, specifically in skin cancer.
authors.affiliation: Université de Lyon 1, F-69003 Lyon, France - CNRS, UMR5534, centre de génétique et de physiologie moléculaires et cellulaires, 16, rue Raphaël Dubois, Villeurbanne, F-69622, France.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Masse
authors.affiliation: Université de Lyon 1, F-69003 Lyon, France - CNRS, UMR5534, centre de génétique et de physiologie moléculaires et cellulaires, 16, rue Raphaël Dubois, Villeurbanne, F-69622, France.
authors.forename: Gweltaz
authors.initials: G
authors.lastname: Agaësse
authors.affiliation: Université de Lyon 1, F-69003 Lyon, France - CNRS, UMR5534, centre de génétique et de physiologie moléculaires et cellulaires, 16, rue Raphaël Dubois, Villeurbanne, F-69622, France.
authors.forename: Odile
authors.initials: O
authors.lastname: Berthier-Vergnes
mesh_terms: D000818:Animals; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D005810:Multigene Family / Q000502:physiology; D012871:Skin Diseases / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics; D012879:Skin Physiological Phenomena / Q000235:genetics*; D059470:Tetraspanins / Q000502:physiology*
chemical_list: D059470:Tetraspanins