title: Inherited thrombophilia and reproductive disorders.
abstract: Apart from its established role in the pathogenesis of venous thromboembolism (VTE), inherited thrombophilia has been proposed as a possible cause of pregnancy loss and vascular gestational complications. There is a lot of controversy in the literature on the relationship between inherited prothrombotic defects and these obstetric complications. This is a review of the literature on inherited thrombophilia and reproductive disorders. Factor V Leiden, prothrombin G20210A mutation, and protein S deficiency seem to be associated with late and recurrent early pregnancy loss, while their impact on other pregnancy complications is conflicting. No definite association has been established between protein C and antithrombin deficiency and adverse pregnancy outcome, primarily due to their low prevalence. Screening is suggested only for women with early recurrent loss or late pregnancy loss. Anticoagulant treatment during pregnancy should be considered for women with complications who were tested positive for thrombophilia.
authors.affiliation: Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece.
authors.forename: Spyros A
authors.initials: SA
authors.lastname: Liatsikos
authors.affiliation: Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsikouras
authors.affiliation: Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece.
authors.forename: Bachar
authors.initials: B
authors.lastname: Manav
authors.affiliation: Department of Obstetrics and Gynecology, Clinicum Aschaffenburg, Teaching Hospital University of Würzburg, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Csorba
authors.affiliation: Department of Obstetrics and Gynecology, Clinicum Aschaffenburg, Teaching Hospital University of Würzburg, Germany.
authors.forename: Georg Friedrich
authors.initials: GF
authors.lastname: von Tempelhoff
authors.affiliation: Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Galazios
keywords: Inherited thrombophilia; recurrent pregnancy loss; reproductive disorders