title: Quantitative assessment of caveolin-1 G14713A polymorphism and cancer susceptibility in the Asian population.
abstract: OBJECTIVE
  The relationship between caveolin-1 (CAV1) G14713A polymorphism and cancer susceptibility remains inconclusive. The current meta-analysis was performed on the basis of a systematic search in electronic databases for a more precise estimation of the associations.
  
  
  METHODS
  Odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.
  
  
  RESULTS
  A total of 12 studies including 4,994 cases and 5,606 controls were involved in this meta-analysis. In the overall analysis, CAV1 G14713A polymorphism was significantly associated with an increased risk of cancer (A vs G: OR =1.77, 95% CI: 1.49-2.10, P het<0.01; [AA + AG] vs GG: OR =2.03, 95% CI: 1.64-2.53, P het<0.01; AA vs [AG + GG]: OR =1.72, 95% CI: 1.40-2.12, P het<0.01; AA vs GG: OR =2.24, 95% CI: 1.69-2.98, P het<0.01; AG vs GG: OR =1.98, 95% CI: 1.62-2.41, P het<0.01). Subgroup analysis by cancer type showed that CAV1 G14713A polymorphism was associated with an increased risk of digestive system cancer and other cancer types.
  
  
  CONCLUSIONS
  Our findings suggest that CAV1 G14713A polymorphisms may modify the risk of cancer, especially digestive system cancer. However, further well-designed studies are warranted to validate this association.
authors.affiliation: Department of Gastroenterology, Cancer Hospital of Jiangxi Province, Nanchang, Jiangxi, Guangzhou, People's Republic of China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Cancer Hospital of Jiangxi Province, Nanchang, Jiangxi, Guangzhou, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Cancer Hospital of Jiangxi Province, Nanchang, Jiangxi, Guangzhou, People's Republic of China.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Song
keywords: cancer; caveolin-1; polymorphism; susceptibility