title: A therapeutic delivery system for chronic osteomyelitis via a multi-drug implant based on three-dimensional printing technology.
abstract: Chronic osteomyelitis is difficult to be cured and often relapses, which presents to be a great challenge to clinicians. We conducted this original study to explore the efficiency of therapeutic alliance for chronic osteomyelitis by a multi-drug implant based on three-dimensional printing technology. We designed and fabricated preciously a multi-drug implant with a multi-layered concentric cylinder construction by three-dimensional (3D) printing technology. Levofloxacin and tobramycin were incorporated into the drug implant in a specific sequence. The drug release property of the drug implant was assayed in vitro We also developed an animal model of chronic osteomyelitis to estimate the effect of the 3D printed multi-drug implant. The results showed that the multi-drug implant had a sustained and programmed drug release property. Levofloxacin and tobramycin which were released from the multi-drug implant worked in tandem to enhance pharmacodynamic action which was similar to a tumor chemotherapy program and were sufficient to treat chronic osteomyelitis. These findings imply that the administration of 3D printed multi-drug implant would be a potential therapeutic method for chronic osteomyelitis. Further studies are required.
authors.affiliation: Department of Orthopedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Weigang
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Chenyi
authors.initials: C
authors.lastname: Ye
authors.affiliation: Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China zhengqxwh@163.com.
authors.forename: Qixin
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D004343:Drug Implants / Q000494:pharmacology*; D065546:Drug Liberation; D064704:Levofloxacin / Q000494:pharmacology; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy*; D011091:Polyesters / Q000737:chemistry; D066330:Printing, Three-Dimensional; D011817:Rabbits; D014031:Tobramycin / Q000494:pharmacology
chemical_list: D004343:Drug Implants; D011091:Polyesters; C033616:poly(lactide); D064704:Levofloxacin; D014031:Tobramycin
keywords: Three-dimensional printing technique; chronic osteomyelitis; drug implant; local drug delivery; rapid prototyping