title: PARP1 is a novel independent prognostic factor for the poor prognosis of chordoma.
abstract: OBJECTIVE
  To evaluate the expression of PARP1 in chordoma and analyzed its association with clinical factors and patients' prognosis.
  
  
  METHODS
  The expression of Poly (ADP-ribose) polymerase 1 (PARP1) in chordoma specimens from 74 chordoma patients (50 primary and 24 recurrent tumors of 50 patients)and 20 distant normal tissue specimens was measured by immunohistochemical staining. The association of PARP1with the clinical factors and patients' prognosis was also analyzed.
  
  
  RESULTS
  Of all the chordoma samples, 78% showed high expression of PARP1, whereas, only 10% of distant normal tissues expressed a high level of PARP1 (p< 0.01). Chi-square analysis revealed that high expression of PARP1 was significantly correlated with tumor recurrence (p< 0.01) and invasion into surrounding muscle (p< 0.01), while the data did not indicate any association with patients' gender, age, tumor location and size (p> 0.05). Kaplan-Meier survival curve and log-rank test showed that continuous disease free survival time (CDFS) was significantly shorter in the PARP1-positive group than in the PARP1-negative group (P= 0.019).
  
  
  CONCLUSIONS
  High expression of PARP1 is significantly associated with chordoma invasion and recurrence. PARP1 may become a potential biomarker for chordoma in predicting its recurrence and patients' prognosis.
authors.forename: Zihua
authors.initials: Z
authors.lastname: Li
authors.forename: Tu
authors.initials: T
authors.lastname: Lv
authors.forename: Youyu
authors.initials: Y
authors.lastname: Liu
authors.forename: Xuesong
authors.initials: X
authors.lastname: Huang
authors.forename: Zhongpeng
authors.initials: Z
authors.lastname: Qiu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002817:Chordoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000401:mortality*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D000071137:Poly (ADP-Ribose) Polymerase-1 / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D000071137:Poly (ADP-Ribose) Polymerase-1
keywords: Chordoma; PARP1; prognosis; recurrence