title: Myocardial T1 mapping for patients with implanted cardiac devices using wideband inversion recovery spoiled gradient echo readout.
abstract: To develop and validate a technique for myocardial T1 mapping in patients with implantable cardioverter defibrillators (ICDs).
  
  
  
  A MOLLI-based pulse sequence, named Wideband-FLASH-MOLLI, was developed by incorporating a fast low angle shot (FLASH) readout and a wideband inversion pulse. The performance of Wideband-FLASH-MOLLI was evaluated using phantom studies and validated in eight healthy volunteers and ten patients with ICDs at 1.5 Tesla. Comparisons were made between Wideband-FLASH-MOLLI, FLASH-MOLLI, and bSSFP-MOLLI sequences.
  
  
  
  In phantom studies, the maximum T1 estimation errors using Wideband-FLASH-MOLLI with and without an ICD were less than 3% for T1 range from 212 to 1673 ms. In all healthy volunteers, there was no significant native myocardial T1 estimation difference using Wideband-FLASH-MOLLI before and after the external attachment of an ICD to the body coil (1178 ± 27 ms versus 1174 ± 33 ms; P = 0.41). Due to the presence of an ICD, the magnitude images acquired using bSSFP-MOLLI and FLASH-MOLLI showed severe artifacts within the myocardium. In contrast, no or negligible device-induced artifacts were noted within the myocardial regions of the healthy volunteers or the patients with ICDs when using Wideband-FLASH-MOLLI.
  
  
  
  This study demonstrates the feasibility of using Wideband-FLASH-MOLLI to mitigate image artifacts and to produce accurate myocardial T1 maps in patients with ICDs. Magn Reson Med 77:1495-1504, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Shao
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Shams
authors.initials: S
authors.lastname: Rashid
authors.affiliation: Department of Radiology, Ronald Reagan-UCLA Medical Center, California, USA.|Irvine College of Medicine, Irvine, California, USA.
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Renella
authors.affiliation: Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Division of Cardiology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA.
authors.forename: Kim-Lien
authors.initials: KL
authors.lastname: Nguyen
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Biomedical Physics Inter-Departmental Graduate Program, University of California, Los Angeles, California, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Hu
mesh_terms: D000328:Adult; D000465:Algorithms; D016477:Artifacts; D057791:Cardiac Imaging Techniques / Q000379:methods*; D017147:Defibrillators, Implantable; D005260:Female; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: ICD; MOLLI; T1 mapping; myocardial fibrosis; wideband