title: Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?
abstract: Study of the effects of natural products, including traditional Chinese Medicines, on acetaminophen hepatotoxicity has gained considerable popularity in recent years, and some of them showed positive results and even promising therapeutic potentials. A recent report suggested that Liuweiwuling tablets protect against acetaminophen hepatotoxicity and promote liver regeneration in a rodent model through alleviating the inflammatory response. However, several concerns exist regarding the limitations of the experimental design and interpretation of the data presented in this manuscript.
authors.affiliation: Kuo Du, Hartmut Jaeschke, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States.
authors.forename: Kuo
authors.initials: K
authors.lastname: Du
authors.affiliation: Kuo Du, Hartmut Jaeschke, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Jaeschke
mesh_terms: D000082:Acetaminophen; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male
chemical_list: D004365:Drugs, Chinese Herbal; D000082:Acetaminophen
keywords: Acetaminophen hepatotoxicity; Liuweiwuling; Liver regeneration; Natural products; Sterile inflammation