title: Quantification of Left Ventricular Function With Premature Ventricular Complexes Reveals Variable Hemodynamics.
abstract: BACKGROUND
  Premature ventricular complexes (PVCs) are prevalent in the general population and are sometimes associated with reduced ventricular function. Current echocardiographic and cardiovascular magnetic resonance imaging techniques do not adequately address the effect of PVCs on left ventricular function.
  
  
  RESULTS
  Fifteen subjects with a history of frequent PVCs undergoing cardiovascular magnetic resonance imaging had real-time slice volume quantification performed using a 2-dimensional (2D) real-time cardiovascular magnetic resonance imaging technique. Synchronization of 2D real-time imaging with patient ECG allowed for different beats to be categorized by the loading beat RR duration and beat RR duration. For each beat type, global volumes were quantified via summation over all slices covering the entire ventricle. Different patterns of ectopy, including isolated PVCs, bigeminy, trigeminy, and interpolated PVCs, were observed. Global functional measurement of the different beat types based on timing demonstrated differences in preload, stroke volume, and ejection fraction. An average of hemodynamic function was quantified for each subject depending on the frequency of each observed beat type.
  
  
  CONCLUSIONS
  Application of real-time cardiovascular magnetic resonance imaging in patients with PVCs revealed differential contribution of PVCs to hemodynamics.
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.). yuchi.han@uphs.upenn.edu.
authors.forename: Francisco
authors.initials: F
authors.lastname: Contijoch
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Kelly
authors.initials: K
authors.lastname: Rogers
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Hannah
authors.initials: H
authors.lastname: Rears
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Mohammed
authors.initials: M
authors.lastname: Shahid
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Peter
authors.initials: P
authors.lastname: Kellman
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Joseph
authors.initials: J
authors.lastname: Gorman
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Robert C
authors.initials: RC
authors.lastname: Gorman
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Paul
authors.initials: P
authors.lastname: Yushkevich
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Erica S
authors.initials: ES
authors.lastname: Zado
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Supple
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Francis E
authors.initials: FE
authors.lastname: Marchlinski
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Walter R T
authors.initials: WR
authors.lastname: Witschey
authors.affiliation: From the Department of Bioengineering (F.C.), Cardiovascular Division, Department of Medicine (K.R., E.S.Z., G.E.S., F.E.M., Y.H.), Department of Radiology (H.R., M.S., P.Y., W.R.T.W.), and Department of Surgery (J.G., R.C.G.), University of Pennsylvania, Philadelphia; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).
authors.forename: Yuchi
authors.initials: Y
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D002306:Cardiac Volume; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume; D016277:Ventricular Function, Left / Q000502:physiology; D018879:Ventricular Premature Complexes / Q000175:diagnosis / Q000503:physiopathology*; D055815:Young Adult
keywords: cardiac arrhythmias; echocardiography; magnetic resonance imaging; stroke volume; ventricular premature complexes