title: Integrative and comparative reproductive biology: From alligators to xenobiotics.
abstract: Dr. Louis J. Guillette Jr. thought of himself as a reproductive biologist. However, his interest in reproductive biology transcended organ systems, life history stages, species, and environmental contexts. His integrative and collaborative nature led to diverse and fascinating research projects conducted all over the world. He doesn't leave us with a single legacy. Instead, he entrusts us with several. The purpose of this review is to highlight those legacies, in both breadth and diversity, and to illustrate Dr. Guillette's grand contributions to the field of reproductive biology. He has challenged the field to reconsider how we think about our data, championed development of novel and innovative techniques to measure endocrine function, helped define the field of endocrine disruption, and lead projects to characterize new endocrine disrupting chemicals. He significantly influenced our understanding of evolution, and took bold and important steps to translate all that he has learned into advances in human reproductive health. We hope that after reading this manuscript our audience will appreciate and continue Dr. Guillette's practice of open-minded and passionate collaboration to understand the basic mechanisms driving reproductive physiology and to ultimately apply those findings to protect and improve wildlife and human health.
authors.affiliation: Department of Biology, East Carolina University, Greenville, NC 278585, USA.
authors.forename: Krista A
authors.initials: KA
authors.lastname: McCoy
authors.affiliation: Department of Biology, Furman University, Greenville, SC 29613, USA.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Roark
authors.affiliation: Environmental Chemical Sciences, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC 29412, USA.
authors.forename: Ashley S P
authors.initials: ASP
authors.lastname: Boggs
authors.affiliation: Environmental Chemical Sciences, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC 29412, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Bowden
authors.affiliation: Department of Biology, Wofford College, Spartanburg, SC 29303, USA.
authors.forename: Lori
authors.initials: L
authors.lastname: Cruze
authors.affiliation: Department of Biology, University of the South, Sewanee, TN 37383, USA.
authors.forename: Thea M
authors.initials: TM
authors.lastname: Edwards
authors.affiliation: School of Marine Sciences, Aquaculture Research Institute, University of Maine, Orono, ME 04469, USA.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Hamlin
authors.affiliation: Department of Obstetrics and Gynecology, Marine Biomedicine and Environmental Science Center, Hollings Marine Laboratory, Medical University of South Carolina, Charleston, SC 29412, USA.
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Cantu
authors.affiliation: Department of Obstetrics and Gynecology, Marine Biomedicine and Environmental Science Center, Hollings Marine Laboratory, Medical University of South Carolina, Charleston, SC 29412, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: McCoy
authors.affiliation: Department of Obstetrics and Gynecology, Marine Biomedicine and Environmental Science Center, Hollings Marine Laboratory, Medical University of South Carolina, Charleston, SC 29412, USA; Graduate Program in Marine Biology, University of Charleston at College of Charleston, Charleston, SC 29412, USA.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: McNabb
authors.affiliation: Environmental Chemical Sciences, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC 29412, USA; Department of Obstetrics and Gynecology, Marine Biomedicine and Environmental Science Center, Hollings Marine Laboratory, Medical University of South Carolina, Charleston, SC 29412, USA.
authors.forename: Abby G
authors.initials: AG
authors.lastname: Wenzel
authors.affiliation: Department of Obstetrics and Gynecology, Marine Biomedicine and Environmental Science Center, Hollings Marine Laboratory, Medical University of South Carolina, Charleston, SC 29412, USA; Graduate Program in Marine Biology, University of Charleston at College of Charleston, Charleston, SC 29412, USA.
authors.forename: Cameron E
authors.initials: CE
authors.lastname: Williams
authors.affiliation: Department of Obstetrics and Gynecology, Marine Biomedicine and Environmental Science Center, Hollings Marine Laboratory, Medical University of South Carolina, Charleston, SC 29412, USA. Electronic address: kohno@musc.edu.
authors.forename: Satomi
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000489:Alligators and Crocodiles / Q000378:metabolism*; D000818:Animals; D005075:Biological Evolution; D052244:Endocrine Disruptors / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D057170:Translational Research, Biomedical; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D052244:Endocrine Disruptors; D015262:Xenobiotics
keywords: Endocrine disrupting chemicals; Evolution of placenta; Louis J. Guillette Jr.; Reproductive biology; Temperature-dependent sex determination; Variation