title: Recurrent mutation at the classical haptoglobin structural polymorphism.
abstract: Polymorphism of haptoglobin in human serum was first discovered over 60 years ago. A new paper characterizes the complex structural variation at the HP locus in detail and, by using imputation from flanking SNP genotype data, shows that it affects blood cholesterol levels.
authors.affiliation: Department of Genetics, University of Leicester, Leicester, UK.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Hollox
authors.affiliation: Department of Health Sciences, University of Leicester, Leicester, UK.
authors.forename: Louise V
authors.initials: LV
authors.lastname: Wain
mesh_terms: D002784:Cholesterol / Q000097:blood*; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D017384:Sequence Deletion
chemical_list: D006242:Haptoglobins; D002784:Cholesterol