title: Ectopic DNMT3B expression delays leukemogenesis.
abstract: In this issue of Blood, Schulze et al use a tetracycline-inducible Dnmt3b knock-in mouse model to investigate how DNMT3B-mediated DNA methylation affects leukemogenesis. Increased DNMT3B expression prolonged survival in retrovirally induced Myc-Bcl2– or MLL-AF9–driven leukemia, and acute myeloid leukemia (AML) patients with high expression of DNMT3B target genes showed inferior overall survival.
authors.affiliation: ALBERT EINSTEIN COLLEGE OF MEDICINE.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Stanley
authors.affiliation: ALBERT EINSTEIN COLLEGE OF MEDICINE.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steidl
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D019175:DNA Methylation; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007938:Leukemia / Q000235:genetics*
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases