title: Increased Serum Level of Cyclopropaneoctanoic Acid 2-Hexyl in Patients with Hypertriglyceridemia-Related Disorders.
abstract: We recently reported the presence of various cyclopropane fatty acids-among them, cyclopropaneoctanoic acid 2-hexyl-in the adipose tissue of obese women. The aim of this study was to verify whether the presence of cyclopropaneoctanoic acid 2-hexyl in human serum was associated with obesity or chronic kidney disease (both being related to dyslipidemia), and to find potential associations between the serum level of this compound and specific markers of the these conditions. The serum concentration of cyclopropaneoctanoic acid 2-hexyl was determined by gas chromatography-mass spectrometry (GC-MS) in non-obese controls, obese patients, obese patients after a 3-month low-calorie diet, and individuals with chronic kidney disease. Obese patients and those with chronic kidney disease presented with higher serum levels of cyclopropaneoctanoic acid 2-hexyl than controls. Switching obese individuals to a low-calorie (low-lipid) diet resulted in a reduction in this fatty acid concentration to the level observed in controls. Cyclopropaneoctanoic acid 2-hexyl was also found in foods derived from animal fat. Serum concentrations of triacylglycerols in the analyzed groups followed a pattern similar to that for serum cyclopropaneoctanoic acid 2-hexyl, and these variables were positively correlated with each other among the studied groups. Patients with hypertriglyceridemia-related conditions presented with elevated serum levels of cyclopropaneoctanoic acid 2-hexyl. Our findings suggest that its high serum level is related to high serum triacylglycerol concentrations rather than to body mass or BMI.
authors.affiliation: Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza Str., 80-308, Gdansk, Poland.
authors.forename: Adriana
authors.initials: A
authors.lastname: Mika
authors.affiliation: Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza Str., 80-308, Gdansk, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Stepnowski
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, 7 Debinki Str., 80-952, Gdansk, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Chmielewski
authors.affiliation: Department of Clinical Nutrition, Medical University of Gdansk, 7 Debinki Str., 80-952, Gdansk, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Malgorzewicz
authors.affiliation: Department of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Kaska
authors.affiliation: Department of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Proczko
authors.affiliation: Department of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ratnicki-Sklucki
authors.affiliation: Department of Emergency Medicine, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Sledzinski
authors.affiliation: Department of Pharmaceutical Biochemistry, Medical University of Gdansk, 1 Dębinki Str., 80-211, Gdansk, Poland. tsledz@gumed.edu.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sledzinski
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D015992:Body Mass Index; D031204:Caloric Restriction; D003521:Cyclopropanes / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D003521:Cyclopropanes; D005227:Fatty Acids; D014280:Triglycerides; C028775:cyclopropane fatty acids
keywords: Chronic kidney disease; Cyclopropaneoctanoic acid 2-hexyl; Hypertriglyceridemia; Obesity