title: Study of lipid status in the euglycemic offsprings of diabetic parents with sex, age matched controls among South Indian population.
abstract: BACKGROUND
  Metabolic syndrome has a silent but a fatal course. So, if we are able to identify the subjects in the early course of the disease then we will be able to prevent them from fatal complications later.
  
  
  OBJECTIVE
  To study the lipid status among euglycemic offspring of diabetic parents by appropriately matching for sex, and age in controls.
  
  
  METHODS
  It is a case control study involving 52 subjects and 25 controls done in a tertiary care center in Chennai.
  
  
  METHODS
  Using inclusion and exclusion criteria 52 euglycemic offspring as subjects and 25 controls were taken. Serum high density lipoprotein (HDL), serum triglycerides, blood pressure and waist circumference we obtained. The results were tabulated and studied.
  
  
  METHODS
  Student t test was employed.
  
  
  RESULTS
  Siblings of diabetic parents had lower levels of serum HDL. Odds ratio showed that offspring's of diabetic parents had the odds of having low HDL 4.67 times when compared to the controls with a confidence interval of 1.6001-13.6563, P value of 0.0048. The other parameters did not show any gross variation. Siblings of diabetic fathers had a more deranged profile than the siblings of diabetic mothers.
  
  
  CONCLUSIONS
  There is significant association between parental diabetic status and dyslipidemia. If they are detected early then progress to complications can be delayed.
authors.affiliation: Undergraduate, Sree Balaji Medical Collage & Hospital, India. Electronic address: drcarltonjohnny@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Carlton Johnny
authors.affiliation: Associate professor, Department of General Medicine, Sree Balaji Medical Collage & Hospital, Bharath University , India. Electronic address: anu_madras@yahoo.com.
authors.forename: N
authors.initials: N
authors.lastname: Anuratha
mesh_terms: D001786:Blood Glucose; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism; D016017:Odds Ratio; D035781:Siblings; D062606:Tertiary Care Centers; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: Diabetic parents; Euglycemic offspring; Metabolic syndrome; Serum HDL