title: Subjective Cognitive Decline: Mapping Functional and Structural Brain Changes-A Combined Resting-State Functional and Structural MR Imaging Study.
abstract: Purpose To determine whether individuals with subjective cognitive decline (SCD) exhibit functional and structural brain alterations by using resting-state functional and structural magnetic resonance (MR) imaging. Materials and Methods This study received institutional review board approval, and all participants gave informed consent. Resting-state functional MR imaging and structural MR imaging techniques were used to measure amplitude of low-frequency fluctuations (ALFF) and regional gray matter volume in 25 subjects with SCD (mean age, 65.52 years ± 6.12) and 61 control subjects (mean age, 64.11 years ± 8.59). Voxel-wise general linear model analyses were used to examine between-group differences in ALFF or in gray matter volume and to further determine the brain-behavioral relationship. Results Subjects with SCD exhibited higher ALFF values than did control subjects in the bilateral inferior parietal lobule (left: 0.44 ± 0.25 vs 0.27 ± 0.18, respectively; P = .0003; right: 1.46 ± 0.45 vs 1.10 ± 0.37, respectively; P = .0015), right inferior (0.45 ± 0.15 vs 0.37 ± 0.08, repectively; P = .0106) and middle (1.03 ± 0.32 vs 0.83 ± 0.20, respectively; P = .0008) occipital gyrus, right superior temporal gyrus (0.11 ± 0.07 vs 0.07 ± 0.04, respectively; P = .0016), and right cerebellum posterior lobe (0.51 ± 0.27 vs 0.39 ± 0.15, respectively; P = .0010). In the SCD group, significant correlations were found between Auditory Verbal Learning Test recognition scores and ALFF in the left inferior parietal lobe (r = -0.79, P < .001) and between Auditory Verbal Learning Test immediate recall scores and ALFF values in the right middle occipital gyrus (r = -0.64, P = .002). Nonsignificant group differences were found in gray matter volume (P > .05, corrected). Conclusion Individuals with SCD had altered spontaneous functional activity, suggesting that resting-state functional MR imaging may be a noninvasive method for characterizing SCD. (©) RSNA, 2016 Online supplemental material is available for this article.
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Zhengjia
authors.initials: Z
authors.lastname: Dai
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Yuxia
authors.identifier: 0000-0002-2740-8538
authors.initials: Y
authors.lastname: Li
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Can
authors.initials: C
authors.lastname: Sheng
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Xiaoni
authors.initials: X
authors.lastname: Wang
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Chen
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.affiliation: From the Department of Neurology, XuanWu Hospital of Capital Medical University, 45 Chang-Chun St, Beijing 10053, China (Y.S., Y.X.L., C.S., H.Y.L., X.N.W., Y. Han); Department of Psychology, Sun Yat-sen University, Guangzhou, China (Z.J.D.); State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Z.J.D., X.D.C., Y. He); and Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China (Y. Han).
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
mesh_terms: D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged