title: Extrahepatic manifestations of hepatitis E virus.
abstract: Hepatitis E virus can cause acute, fulminant and chronic hepatitis and has been associated with a range of extrahepatic manifestations. Guillain-Barré syndrome, neuralgic amyotrophy and encephalitis are the main neurological manifestations associated with acute and chronic hepatitis E virus infection. Renal injuries have been also reported, including membranoproliferative glomerulonephritis with or without cryoglobulinemia and membranous glomerulonephritis. Acute pancreatitis, haematological disorders and other autoimmune extrahepatic manifestations of hepatitis E virus, such as myocarditis and thyroiditis, have been also reported. In this comprehensive article, we review all published reports describing hepatitis E virus-associated extrahepatic manifestations.
authors.affiliation: Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.|INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.|Université Paul Sabatier, Toulouse, France.
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.affiliation: Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Marion
authors.affiliation: INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.|Université Paul Sabatier, Toulouse, France.|Department of Virology, CHU Purpan, Toulouse, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Abravanel
authors.affiliation: INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.|Université Paul Sabatier, Toulouse, France.|Department of Virology, CHU Purpan, Toulouse, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
authors.affiliation: Cornwall Gastrointestinal Unit, Royal Cornwall Hospital and European Centre for the Environment and Human Health, University of Exeter Medical School, Truro, UK.
authors.forename: Harry R
authors.initials: HR
authors.lastname: Dalton
mesh_terms: D000208:Acute Disease; D000740:Anemia / Q000175:diagnosis / Q000821:virology*; D000818:Animals; D003449:Cryoglobulinemia / Q000175:diagnosis / Q000821:virology*; D016751:Hepatitis E / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D016752:Hepatitis E virus / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000821:virology*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000821:virology*; D010195:Pancreatitis / Q000175:diagnosis / Q000821:virology*; D012307:Risk Factors; D013921:Thrombocytopenia / Q000175:diagnosis / Q000821:virology*
keywords: Anaemia; Guillain-Barré syndrome; hepatitis E virus; kidney disease; neuralgic amyotrophy; pancreatitis; thrombocytopenia