title: Update on Metastatic Uveal Melanoma: Progress and Challenges.
abstract: Uveal melanoma is a rare and biologically distinct type of melanoma arising from melanocytes of the uveal tract; it is associated with a poor prognosis due to the lack of effective systemic treatments. Recent advances in the pathogenesis of uveal melanoma offer an unprecedented opportunity for investigation of new compounds. The purpose of this paper was to analyse the existing evidence about the molecular pathology and immunobiology of advanced uveal melanoma and their implications for systemic targeted therapies and immunotherapy, as well as to discuss future treatment strategies based on data provided by clinical and translational research studies.
authors.affiliation: Department of Plastic and Reconstructive Surgery, IRCCS San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. francesco.spagnolo85@gmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Spagnolo
authors.affiliation: Department of Medical Oncology, IRCCS San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Picasso
authors.affiliation: Department of Medical Oncology, IRCCS San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Spano
authors.affiliation: Department of Medical Oncology, IRCCS San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Tanda
authors.affiliation: University of Genoa, Genoa, Italy.
authors.forename: Clary
authors.initials: C
authors.lastname: Venzano
authors.affiliation: Department of Medical Oncology, IRCCS San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Queirolo
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008545:Melanoma / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D058990:Molecular Targeted Therapy; D009154:Mutation; D014604:Uveal Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D000098943:Uveal Melanoma
chemical_list: D000970:Antineoplastic Agents