title: Hyperglycemia and Inflammatory Property of Circulating Monocytes are Associated with Inflammatory Property of Carotid Plaques in Patients Undergoing Carotid Endarterectomy.
abstract: OBJECTIVE
  This study aims to determine the association between glucose metabolism and proinflammatory/anti-inflammatory properties of circulating monocytes or those of carotid plaques in patients who underwent carotid endarterectomy.
  
  
  METHODS
  Clinical characteristics and expression levels of proinflammatory/anti-inflammatory markers in circulating monocytes/carotid plaques were examined in 12 patients with diabetes and 12 patients without diabetes.
  
  
  RESULTS
  Circulating monocytes from patients with diabetes revealed higher tumor necrosis factor (TNF)-α and lower interleukin (IL)-10 expression levels compared with those from patients without diabetes, which was also observed in carotid plaques from patients with diabetes. Hyperglycemia revealed positive and negative correlations with the ratios of IL-6＋and IL-10＋cells in carotid plaques, respectively. Moreover, we determined a positive correlation between circulating monocytes and carotid plaques with respect to TNF-α and IL-6 expressions.
  
  
  CONCLUSIONS
  The inflammatory property of circulating monocytes was associated with that of carotid plaques. Hyperglycemia increased inflammatory properties and decreased anti-inflammatory properties of carotid plaques.
authors.affiliation: Division of Diabetic Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center.
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Shinya
authors.initials: S
authors.lastname: Masuda
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamakage
authors.forename: Kazuya
authors.initials: K
authors.lastname: Muranaka
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Wada
authors.forename: Koji
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
authors.forename: Noriko
authors.initials: N
authors.lastname: Satoh-Asahara
mesh_terms: D000368:Aged; D002340:Carotid Artery Diseases / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D016893:Carotid Stenosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016894:Endarterectomy, Carotid / Q000009:adverse effects*; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D007124:Immunoenzyme Techniques; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D018836:Inflammation Mediators