title: A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.
abstract: Plasma lipidomic profile is species specific and an optimized feature associated with animal longevity. In the present work, the use of mass spectrometry technologies allowed us to determine the plasma lipidomic profile and the fatty acid pattern of healthy humans with exceptional longevity. Here, we show that it is possible to define a lipidomic signature only using 20 lipid species to discriminate adult, aged and centenarian subjects obtaining an almost perfect accuracy (90%-100%). Furthermore, we propose specific lipid species belonging to ceramides, widely involved in cell-stress response, as biomarkers of extreme human longevity. In addition, we also show that extreme longevity presents a fatty acid profile resistant to lipid peroxidation. Our findings indicate that lipidomic signature is an optimized feature associated with extreme human longevity. Further, specific lipid molecular species and lipid unsaturation arose as potential biomarkers of longevity.
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Spain.
authors.forename: Mariona
authors.initials: M
authors.lastname: Jové
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Naudí
authors.affiliation: Department of Physiology, University of Valencia, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Gambini
authors.affiliation: Department of Physiology, University of Valencia, Spain.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Borras
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Spain.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Cabré
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Portero-Otín
authors.affiliation: Department of Physiology, University of Valencia, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Viña
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Spain. reinald.pamplona@mex.udl.cat.
authors.forename: Reinald
authors.initials: R
authors.lastname: Pamplona
mesh_terms: D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008136:Longevity; D008297:Male; D013058:Mass Spectrometry; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D008055:Lipids
keywords: Centenarians; Fatty acid unsaturation; Lipid molecular species; Mass spectrometry; Peroxidizability index