title: [Effect of occupational exposure to toluene diisocyanate on workers' health].
abstract: OBJECTIVE
  To investigate the effect of occupational exposure to toluene diisocyanate (TDI) on the workers' health.
  
  
  METHODS
  A total of 76 workers exposed to TDI (exposure group) and 64 management staff members (control group) were selected from a factory as the study subjects. Area sampling was performed for the place with exposure to TDI according to the method in GBZ 159-2004 Specifications of air sampling for hazardous substances monitoring in the workplace, and gas chromatography was applied to measure the concentration of TDI in workplace air. The workers' personal information was collected with questionnaire, pulmonary ventilation function was determined with a portable spirometer, hematological parameters were analyzed by automatic blood analyzer and blood chemistry analyzer, and the indicators of oxidative damage and energy metabolism were measured by the reagent kit provided by Nanjing Jiancheng Bioengineering Institute. SPSS 17 software was applied for statistical analysis.
  
  
  RESULTS
  The exposure group had significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second(FEV1.0), and FEV1.0/FVC ratio than the control group (P <0.05). Compared with the control group, the exposure group had significantly higher red blood cell count, platelet distribution width, mean platelet volume, lymphocyte count, and neutrophil count(P<0.01), and significantly lower activities of lactate dehydrogenase(LDH), superoxide dismutase, and succinodehydrogenase (SDH)(P <0.01). In the exposure group, the length of exposure was negatively correlated with the activities of SDH and LDH in the serum (r=-0.319, P <0.05; r=-0.239, P <0.05), and the length of exposure was not found to be correlated with the activity of SOD and pulmonary function indices.
  
  
  CONCLUSIONS
  TDI can induce inflammatory response and lung ventilation function impairment in workers exposed to TDI, as well as oxidative stress and imbalance of energy metabolism. Therefore, it can cause damage to workers' health, and protective measures should be enhanced.
authors.affiliation: Shandong Academy of Medical Sciences, Shandong Academy of Occupational Health and Occupational Medicine Shandong Institude of Prevention and Control of Occupational Health and Occupational Disease, Jinan 250062, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ju
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jia
authors.forename: Tao
authors.initials: T
authors.lastname: Meng
authors.forename: Cuijuan
authors.initials: C
authors.lastname: Wang
authors.forename: Xuelei
authors.initials: X
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Niu
authors.forename: Xiao
authors.initials: X
authors.lastname: Meng
authors.forename: Xiao
authors.initials: X
authors.lastname: Geng
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Ma
authors.forename: Qixiang
authors.initials: Q
authors.lastname: Jia
authors.forename: Panpan
authors.initials: P
authors.lastname: Miao
authors.forename: Yufei
authors.initials: Y
authors.lastname: Dai
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zheng
authors.forename: Hua
authors.initials: H
authors.lastname: Shao
mesh_terms: D016022:Case-Control Studies; D004906:Erythrocyte Count; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D007958:Leukocyte Count; D008168:Lung / Q000503:physiopathology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012123:Pulmonary Ventilation; D013385:Succinate Dehydrogenase / Q000097:blood / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*; D014797:Vital Capacity
chemical_list: D014051:Toluene 2,4-Diisocyanate; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D013385:Succinate Dehydrogenase