title: Gianotti-Crosti syndrome as presenting sign of cytomegalovirus infection: A case report and a critical appraisal of its possible cytomegalovirus etiology.
abstract: Gianotti-Crosti syndrome (GCS) is a self-limiting exanthem of acute onset with a characteristic acral distribution, usually occurring in children. It is characterized by symmetric pink to red-brown papular or papulovesicular lesions that are a few millimetres in diameter, distributed on the face, buttocks and limbs. It may be accompanied by low-grade fever, hepato-splenomegaly and lymphadenopathy. GCS is considered a unique cutaneous response to viral infection, mostly associated with hepatitis B virus and Epstein-Barr virus (EBV), but other viruses, bacterial infections and recent immunizations may be inciting factors. We report a case of a 3-year-old girl presenting generalized, pruritic, papulovesicular eruption on the face and extremities for one month. In our case, GCS was related to cytomegalovirus (CMV) primary infection and may be considered the presenting sign of the infection.
authors.affiliation: IRCCS A.O.U. San Martino-IST, Department of Dermatology, Largo Rosanna Benzi 10, Genoa 16132, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Drago
authors.affiliation: IRCCS A.O.U. San Martino-IST, Department of Dermatology, Largo Rosanna Benzi 10, Genoa 16132, Italy. Electronic address: javor.med@gmail.com.
authors.forename: Sanja
authors.initials: S
authors.lastname: Javor
authors.affiliation: IRCCS A.O.U. San Martino-IST, Department of Dermatology, Largo Rosanna Benzi 10, Genoa 16132, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ciccarese
authors.affiliation: IRCCS A.O.U. San Martino-IST, Department of Dermatology, Largo Rosanna Benzi 10, Genoa 16132, Italy.
authors.forename: Aurora
authors.initials: A
authors.lastname: Parodi
mesh_terms: D000169:Acrodermatitis / Q000209:etiology* / Q000473:pathology*; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans
keywords: Cytomegalovirus infection; Etiology; Gianotti-Crosti syndrome (GCS)