title: Combination of Escitalopram and Rasagiline Induced Serotonin Syndrome: A Case Report and Review Literature.
abstract: BACKGROUND
  Serotonin syndrome is a rare but potentially fatal complication of drugs that have effects on central nervous system serotonin. It is characterized by sudden onset of altered mental status, increased neuromuscular activity, and autonomic instability.
  
  
  METHODS
  The authors reported a case of serotonin syndrome associated with combined therapy of monoamine oxidase-B inhibitors and selective serotonin reuptake inhibitor A 77-year-old Thai man had been taking escitalopram for depression for three years. He presented with high-grade fever and confusion two days after taking rasagiline for Parkinson's disease. He also had agitation, hallucination, and behavioral change. Escitalopram and rasagiline were discontinued but his renal function worsened, turning to acute kidney injury. He was diagnosed as serotonin syndrome.
  
  
  CONCLUSIONS
  This is the first case report of serotonin syndrome due to combination of escitalopram and rasagiline used.
authors.forename: Juthathip
authors.initials: J
authors.lastname: Suphanklang
authors.forename: Wichai
authors.initials: W
authors.lastname: Santimaleeworagun
authors.forename: Ouppatham
authors.initials: O
authors.lastname: Supasyndh
mesh_terms: D000368:Aged; D015283:Citalopram / Q000008:administration & dosage / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy; D006801:Humans; D007189:Indans / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy; D020230:Serotonin Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D015283:Citalopram; D007189:Indans; D017367:Selective Serotonin Reuptake Inhibitors; C031967:rasagiline