title: Pd/C Catalyzed Carbonylation of Azides in the Presence of Amines.
abstract: A facile and efficient Pd/C-catalyzed carbonylation of both aliphatic and aromatic azides in the presence of amines is reported. Serving as the widely existed fragments in an array of biological pharmaceuticals, functionalized unsymmetrical ureas were straightforwardly synthesized by using readily available and cheap azides with amines under CO atmosphere, with the extrusion of N2 as the only byproduct. It was found that not only aryl azides but also benzyl and alkyl azides were suited for this methodology. Another feature of this procedure was the employment of a highly efficient palladium charcoal catalytic system.
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Zongyang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Shuaihu
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Shiyang
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Ming-An
authors.initials: MA
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Fu
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D001686:Biological Phenomena; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
chemical_list: D000588:Amines; D001386:Azides; D010165:Palladium; D014508:Urea