title: Thiol/Disulfide Homeostasis in Patients with Central Serous Chorioretinopathy.
abstract: To evaluate dynamic thiol/disulfide homeostasis in patients with chronic central serous chorioretinopathy (cCSC).
  
  
  
  This prospective study included 34 cCSC cases and 37 healthy individuals who were age- and sex-matched. A new colorimetric method for measuring thiol/disulfide homeostasis was used. Native thiol, total thiol/disulfide levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were measured.
  
  
  
  The age and gender distributions were similar in both main groups. The mean duration of disease was 47.29 ± 24 months. Native and total thiol levels were significantly lower among the cCSC group relative to the control group (p < 0.001). There was not a statistically significant difference between the cCSC and the control group in terms of disulfide levels (p = 0.492). While disulfide/native thiol and disulfide/total thiol ratios were elevated, the native thiol/total thiol ratio was decreased in the cCSC group (p = 0.017, 0.021, 0.036, respectively). Ratios obtained using plasma native thiol, total thiol, and disulfide levels differed significantly between the both groups.
  
  
  
  Disulfide/thiol ratio was significantly greater in cCSC patients relative to healthy control subjects. Our results suggest that the oxidative process is involved in the pathogenesis of the cCSC.
authors.affiliation: a Department of Ophthalmology , Akdeniz University , Antalya , Turkey.
authors.forename: Elif Betul
authors.initials: EB
authors.lastname: Turkoglu
authors.affiliation: b Department of Ophthalmology , Inonu University , Malatya , Turkey.
authors.forename: Seyhan
authors.initials: S
authors.lastname: Dikci
authors.affiliation: c Department of Biochemistry , Sakarya Training and Research Hospital , Sakarya , Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Çelik
authors.affiliation: d Department of Biochemistry , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Erel
authors.affiliation: e Department of Biochemistry , Atatürk Training and Research Hospital , Ankara , Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neselioglu
authors.affiliation: d Department of Biochemistry , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alışık
authors.affiliation: d Department of Biochemistry , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D056833:Central Serous Chorioretinopathy / Q000097:blood* / Q000175:diagnosis; D002908:Chronic Disease; D004220:Disulfides / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006706:Homeostasis; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011446:Prospective Studies; D013438:Sulfhydryl Compounds / Q000097:blood*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Antioxidant; automated quantitation; mercaptan; oxidative stress; retina