title: THE ROLE OF FIBRIN GLUE AND SUTURE ON THE FIXATION OF ULTRA FROZEN PRESERVED MENISCUS TRANSPLANTATION IN RABBITS.
abstract: OBJECTIVE
  To evaluate the ability of fibrin adhesive in promoting the meniscus fixation within two, four and eight weeks compared to the conventional soft-tissue suture technique.
  
  
  METHODS
  36 right medial menisci of rabbits preserved at negative 73° Celsius for 30 days were transplanted to animals of the same sample and fixed with soft-tissue suture or fibrin glue. After 2, 4 or 8 weeks, the appearance of the menisci and the quality of fixation were macroscopically checked and evaluated by a scoring system. The findings were subjected to the statistical study of variance analysis (p ≤ 0.05%).
  
  
  RESULTS
  The deep-frozen meniscus preservation maintained the integrity of the meniscus transplant, and, macroscopically, there was no significant reduction of the length of the meniscus in all post-transplant periods (p = 0.015). The menisci fixed with fibrin showed slight changes in color and surface roughness. There were no signs of rejection or infection in both groups. Suture fixation scoring was superior (p = 0.015) in all periods (80% of total fixation) as compared to the setting promoted by fibrin (20% of total fixation).
  
  
  CONCLUSIONS
  The homologous transplantation of the meniscus of rabbits experienced various degrees of integration to the knee according to the fixation method; the surgical soft tissues suturing technique was shown to be superior in the evaluation of scores compared to the fixation with fibrin adhesive.
authors.affiliation: Doctor's degree in Science, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Leandro José
authors.initials: LJ
authors.lastname: Reckers
authors.affiliation: Associate Professor and Lecturer, Department of Surgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Djalma José
authors.initials: DJ
authors.lastname: Fagundes
authors.affiliation: Doctor's degree in Science, Universidade Federal de São Paulo (UNIFESP); Associate Professor, Department of Orthopedics, Universidade Federal de of Pelotas, Brazil.
authors.forename: José Luiz
authors.initials: JL
authors.lastname: Pozo Raymundo
authors.affiliation: Master's degree in Science, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Geraldo Sérgio de Mello
authors.initials: GS
authors.lastname: Granata Júnior
authors.affiliation: Veterinarian, Doctor's degree in Science, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Márcia Bento
authors.initials: MB
authors.lastname: Moreira
authors.affiliation: Veterinarian, Master's degree in Science, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Vanessa Carla
authors.initials: VC
authors.lastname: Paiva
authors.affiliation: Medical Student, Universidade de Santo Amaro (UNISA), São Paulo, Brazil.
authors.forename: Anna Luiza
authors.initials: AL
authors.lastname: Negrini Fagundes
authors.affiliation: Associate Professor and Lecturer, Department of Orthopedics, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Moises
authors.initials: M
authors.lastname: Cohen
keywords: Fibrin tissue adhesive; Meniscus; Rabbits; Transplantation