title: The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells.
abstract: Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.
authors.affiliation: Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Bimonte
authors.affiliation: Animal Facility Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Barbieri
authors.affiliation: Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Leongito
authors.affiliation: Animal Facility Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Palma
authors.affiliation: Animal Facility Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Vitale
authors.initials: V
authors.lastname: Del Vecchio
authors.affiliation: Animal Facility Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Falco
authors.affiliation: Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Palaia
authors.affiliation: Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Albino
authors.affiliation: Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Piccirillo
authors.affiliation: Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Amore
authors.affiliation: Division of Radiology, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Petrillo
authors.affiliation: Division of Radiology, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Granata
authors.affiliation: Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Izzo