title: Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials.
abstract: Exposure to particulate matter (PM) from traffic vehicles is hazardous to the vascular system, leading to clinical manifestations and mortality due to ischemic heart disease. By analogy, nanomaterials may also be associated with the same outcomes. Here, the effects of exposure to PM from ambient air, diesel exhaust and certain nanomaterials on atherosclerosis and vasomotor function in animals have been assessed. The majority of studies have used pulmonary exposure by inhalation or instillation, although there are some studies on non-pulmonary routes such as the gastrointestinal tract. Airway exposure to air pollution particles and nanomaterials is associated with similar effects on atherosclerosis progression, augmented vasoconstriction and blunted vasorelaxation responses in arteries, whereas exposure to diesel exhaust is associated with lower responses. At present, there is no convincing evidence of dose-dependent effects across studies. Oxidative stress and inflammation have been observed in the arterial wall of PM-exposed animals with vasomotor dysfunction or plaque progression. From the data, it is evident that pulmonary and systemic inflammation does not seem to be necessary for these vascular effects to occur. Furthermore, there is inconsistent evidence with regard to altered plasma lipid profile and systemic inflammation as a key step in vasomotor dysfunction and progression of atherosclerosis in PM-exposed animals. In summary, the results show that certain nanomaterials, including TiO2, carbon black and carbon nanotubes, have similar hazards to the vascular system as combustion-derived PM.
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Peter
authors.initials: P
authors.lastname: Møller
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Daniel Vest
authors.initials: DV
authors.lastname: Christophersen
authors.affiliation: b The National Research Centre for the Working Environment , Copenhagen , Denmark.
authors.forename: Nicklas Raun
authors.initials: NR
authors.lastname: Jacobsen
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Astrid
authors.initials: A
authors.lastname: Skovmand
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Ana Cecília Damião
authors.initials: AC
authors.lastname: Gouveia
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Maria Helena Guerra
authors.initials: MH
authors.lastname: Andersen
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Ali
authors.initials: A
authors.lastname: Kermanizadeh
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Ditte Marie
authors.initials: DM
authors.lastname: Jensen
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Pernille Høgh
authors.initials: PH
authors.lastname: Danielsen
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Martin
authors.initials: M
authors.lastname: Roursgaard
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Kim
authors.initials: K
authors.lastname: Jantzen
authors.affiliation: a Section of Environmental Health, Department of Public Health , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Steffen
authors.initials: S
authors.lastname: Loft
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D049329:Nanostructures / Q000633:toxicity*; D052638:Particulate Matter / Q000506:poisoning / Q000633:toxicity*; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology
chemical_list: D052638:Particulate Matter
keywords: Air pollution; atherosclerosis; nanomaterials; particulate matter; vasomotor dysfunction