title: The Role of miRNAs in Cartilage Homeostasis.
abstract: Osteoarthritis (OA) is an age-related disease with poorly understood pathogenesis. Recent studies have demonstrated that miRNA might play a key role in OA initiation and development. We reviewed recent publications and elucidated the connection between miRNA and OA cartilage anabolic and catabolic signals, including four signaling pathways: TGF-β/Smads and BMPs signaling, associated with cartilage anabolism; and MAPK and NF-KB signaling, associated with cartilage catabolism. We also explored the relationships with MMP, ADAMTS and NOS (NitricOxide Synthases) families, as well as with the catabolic cytokines IL-1 and TNF-α. The potential role of miRNAs in biological processes such as cartilage degeneration, chondrocyte proliferation, and differentiation is discussed. Collective evidence indicates that miRNAs play a critical role in cartilage degeneration. These findings will aid in understanding the molecular network that governs articular cartilage homeostasis and in to elucidate the role of miRNA in the pathogenesis of OA.
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;
authors.forename: Yong Ping
authors.initials: YP
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;
authors.forename: Xiao Chun
authors.initials: XC
authors.lastname: Wei
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;
authors.forename: Peng Cu
authors.initials: PC
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;
authors.forename: Chun Wei
authors.initials: CW
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;
authors.forename: Xiao Hu
authors.initials: XH
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jiao
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;
authors.forename: Dong Ming
authors.initials: DM
authors.lastname: Wang
authors.affiliation: Foot and Ankle Orthopaedic Surgery Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
authors.forename: Fang Yuan
authors.initials: FY
authors.lastname: Wei
authors.affiliation: Foot and Ankle Orthopaedic Surgery Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
authors.forename: Jian Zhong
authors.initials: JZ
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China;; Foot and Ankle Orthopaedic Surgery Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China; ; Department of Orthopaedics, The Warren Alpert Medical School of Brown University/Rhode Island Hospital, 1 Hoppin Street, Providence, RI 02903, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Wei
keywords: Cartilage; Chondrocytes.; Homeostasis; Osteoarthritis; miRNA