title: Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics.
abstract: Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD.
authors.affiliation: Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. hexuyun1993@126.com.
authors.forename: Xuyun
authors.initials: X
authors.lastname: He
authors.affiliation: Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. jiliver@vip.sina.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Ji
authors.affiliation: Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. wjia@cc.hawaii.edu.|Center for Translational Medicine, and Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. wjia@cc.hawaii.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. houkai1976@126.com.
authors.forename: Houkai
authors.initials: H
authors.lastname: Li
mesh_terms: D004734:Energy Metabolism; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007333:Insulin Resistance; D055432:Metabolomics; D065626:Non-alcoholic Fatty Liver Disease / Q000382:microbiology*
keywords: NAFLD; bile acids; choline; gut microbiota; insulin resistance; obesity