title: Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments.
abstract: Most cases of colorectal cancer (CRC) are sporadic, and numerous studies have suggested that gut microbiota may play a crucial role in CRC development. Escherichia coli is a member of the gut microbiota frequently associated with colorectal tumors. CRC-associated E. coli strains frequently harbor the pks genomic island. This genomic island is responsible for the synthesis of colibactin genotoxin, which increases tumor numbers in CRC mouse models. We recently showed that targeting ClbP, a key enzyme involved in colibactin synthesis, blocks the deleterious effect of this toxin in vitro and leads to a significant decrease in tumor numbers in vivo. Altogether, our results suggest that the personalized treatment of CRC should also take into consideration the bacteria associated with the tumor in order to limit their deleterious effects.
authors.affiliation: a Microbes, Inflammation, Intestin et Susceptibilité de l'Hôte (M2iSH), Clermont Université, Université d'Auvergne, Inserm U1071, INRA USC2018 , Clermont-Ferrand , France.|b Laboratoire de Bactériologie, Center Hospitalier Universitaire , Clermont-Ferrand , France.|c Institut Universitaire de Technologie, Université d'Auvergne , Aubière , France.
authors.forename: T
authors.initials: T
authors.lastname: Faïs
authors.affiliation: a Microbes, Inflammation, Intestin et Susceptibilité de l'Hôte (M2iSH), Clermont Université, Université d'Auvergne, Inserm U1071, INRA USC2018 , Clermont-Ferrand , France.|b Laboratoire de Bactériologie, Center Hospitalier Universitaire , Clermont-Ferrand , France.|c Institut Universitaire de Technologie, Université d'Auvergne , Aubière , France.
authors.forename: J
authors.initials: J
authors.lastname: Delmas
authors.affiliation: a Microbes, Inflammation, Intestin et Susceptibilité de l'Hôte (M2iSH), Clermont Université, Université d'Auvergne, Inserm U1071, INRA USC2018 , Clermont-Ferrand , France.|c Institut Universitaire de Technologie, Université d'Auvergne , Aubière , France.
authors.forename: A
authors.initials: A
authors.lastname: Cougnoux
authors.affiliation: a Microbes, Inflammation, Intestin et Susceptibilité de l'Hôte (M2iSH), Clermont Université, Université d'Auvergne, Inserm U1071, INRA USC2018 , Clermont-Ferrand , France.|c Institut Universitaire de Technologie, Université d'Auvergne , Aubière , France.
authors.forename: G
authors.initials: G
authors.lastname: Dalmasso
authors.affiliation: a Microbes, Inflammation, Intestin et Susceptibilité de l'Hôte (M2iSH), Clermont Université, Université d'Auvergne, Inserm U1071, INRA USC2018 , Clermont-Ferrand , France.|b Laboratoire de Bactériologie, Center Hospitalier Universitaire , Clermont-Ferrand , France.|c Institut Universitaire de Technologie, Université d'Auvergne , Aubière , France.
authors.forename: R
authors.initials: R
authors.lastname: Bonnet
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D044404:Genomic Islands / Q000187:drug effects; D006801:Humans; D051379:Mice; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000378:metabolism / Q000633:toxicity; D061065:Polyketides / Q000378:metabolism / Q000633:toxicity; D057285:Precision Medicine
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D010455:Peptides; D061065:Polyketides; C569566:colibactin; C577770:ClbP protein, E coli; D010447:Peptide Hydrolases
keywords: ClbP; E. coli; colibactin; colorectal cancer; microbiota; pks