title: Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome.
abstract: OBJECTIVE
  To report on the clinical data of seven patients with T-cell intraocular lymphoma (IOL).
  
  
  METHODS
  Retrospective case series.
  
  
  RESULTS
  Seven immunocompetent patients, 12 eyes, 6 women, with T-cell-IOL were included from five countries. Mean age was 53.5 years (range: 25-82). Four patients had systemic-ocular lymphoma, two had CNS-ocular lymphoma, and one had systemic-CNS- ocular lymphoma. Vitritis was the most frequent clinical sign, followed by anterior uveitis and serous retinal detachment. Cytopathologic examination was performed on all ocular specimens (vitreous in six and iris mass biopsy in one patient). Adjunctive diagnostic procedures included immunohistochemistry, molecular tests, and cytokine profiling of vitreous samples. Treatment modalities included systemic chemotherapy (five patients), intravitreal methotrexate (three patients), globe radiotherapy, and intrathecal chemotherapy. Mean survival from diagnosis was 21.7 months (range: 2-69). Two patients are still alive.
  
  
  CONCLUSIONS
  T-cell IOL has variable clinical manifestations and prognosis. Systemic involvement, SRD, and vitreoretinal involvement were frequently observed.
authors.affiliation: a Centre Hospitalo-Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Florence
authors.initials: F
authors.lastname: Chaput
authors.affiliation: b Hadassah-Hebrew University Medical Centre , Jerusalem , Israel.
authors.forename: Radgonde
authors.initials: R
authors.lastname: Amer
authors.affiliation: c Hôpital Universitaire Genève , Geneva , Switzerland.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Baglivo
authors.affiliation: d Hôpital Universitaire La Pitié Salpêtrière , Paris , France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Touitou
authors.affiliation: e Clinique St Luc, Université Catholique de Louvain , Brussels , Belgium.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kozyreff
authors.affiliation: f Institut Bordet, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bron
authors.affiliation: d Hôpital Universitaire La Pitié Salpêtrière , Paris , France.
authors.forename: Bahram
authors.initials: B
authors.lastname: Bodaghi
authors.affiliation: d Hôpital Universitaire La Pitié Salpêtrière , Paris , France.
authors.forename: Phuc
authors.initials: P
authors.lastname: LeHoang
authors.affiliation: g Department of Ophthalmology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Bergstrom
authors.affiliation: g Department of Ophthalmology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
authors.affiliation: h National Institute of Heath, NEI, Laboratory of Pathology , Bethesda , Maryland , USA.
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
authors.affiliation: b Hadassah-Hebrew University Medical Centre , Jerusalem , Israel.
authors.forename: Jacob
authors.initials: J
authors.lastname: Pe'er
authors.affiliation: a Centre Hospitalo-Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Laure E
authors.initials: LE
authors.lastname: Caspers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D005134:Eye Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007278:Injections, Spinal; D064090:Intraocular Lymphoma / Q000175:diagnosis / Q000188:drug therapy; D058449:Intravitreal Injections; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011878:Radiotherapy; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate
keywords: Intraocular lymphoma; T-lymphoma; primary vitreoretinal lymphoma; uveitis