title: Targeting Antibiotic Resistance.
abstract: Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled "Combat drug resistance: no action today means no cure tomorrow" triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.
authors.affiliation: Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
authors.forename: Mathieu F
authors.identifier: 0000-0002-3802-672X
authors.initials: MF
authors.lastname: Chellat
authors.affiliation: Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
authors.forename: Luka
authors.identifier: 0000-0001-5383-3012
authors.initials: L
authors.lastname: Raguž
authors.affiliation: Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland. rainer.riedl@zhaw.ch.
authors.forename: Rainer
authors.identifier: 0000-0003-2534-1963
authors.initials: R
authors.lastname: Riedl
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000378:metabolism; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology; D056004:Molecular Dynamics Simulation; D010755:Organophosphates / Q000737:chemistry / Q000494:pharmacology; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology; D023303:Oxazolidinones / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018942:Macrolides; D010755:Organophosphates; D010080:Oxazoles; D023303:Oxazolidinones; C515040:tedizolid phosphate
keywords: antibiotic resistance; antibiotics; drug design; medicinal chemistry; structure-activity relationships