title: Highly immunogenic variant of attenuated vaccinia virus.
abstract: The LIVPΔ6 strain of vaccinia virus (VACV) was created by genetic engineering on the basis of previously obtained attenuated 1421ABJCN strain by target deletion of the A35R gene encoding an inhibitor of antigen presentation by the major histocompatibility complex class II. 1421ABJCN is the LIVP strain of VACV with five inactivated virulence genes encoding hemagglutinin (A56R), γ-interferon-binding protein (B8R), thymidine kinase (J2R), complement-binding protein (C3L), and Bcl2-like inhibitor of apoptosis (N1L). The highly immunogenic LIVPΔ6 strain could be an efficient fourth-generation attenuated vaccine against smallpox and other orthopoxvirus infections.
authors.affiliation: Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia. snshchel@vector.nsc.ru.
authors.forename: S N
authors.initials: SN
authors.lastname: Yakubitskyi
authors.affiliation: Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Kolosova
authors.affiliation: Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia.
authors.forename: R A
authors.initials: RA
authors.lastname: Maksyutov
authors.affiliation: Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Shchelkunov
mesh_terms: D000818:Animals; D002460:Cell Line; D017353:Gene Deletion; D000071497:Immunogenicity, Vaccine; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012900:Smallpox Vaccine / Q000235:genetics / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology*; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: C547103:A35R protein, Vaccinia virus; D012900:Smallpox Vaccine; D014613:Vaccines, Attenuated; D014764:Viral Proteins