title: MRI-guided celiac plexus neurolysis for pancreatic cancer pain: Efficacy and safety.
abstract: To prospectively determine the efficacy and safety of magnetic resonance imaging (MRI)-guided celiac plexus neurolysis (CPN) for pancreatic cancer pain.
  
  
  
  In all, 39 patients with pancreatic cancer underwent 0.23T MRI-guided CPN with ethanol via the posterior approach. The pain relief, the opioid intake, and pain interference with appetite, sleep, and communication in patients were assessed after CPN during a 4-month follow-up period. The complications were also evaluated during or after CPN.
  
  
  
  CPN procedures were successfully completed for all patients. Minor complications included diarrhea (9 of 39; 23.1%), orthostatic hypotension (14 of 39; 35.9%), and local backache (20 of 39; 51.3%). No major complication occurred. Pain relief was observed in 36 (92.3%), in 15 (40.5%), and in 11 (35.5%) patients at 1-, 2-, and 3-month visits, respectively. The median duration of pain relief was 2.9 months (95% confidence interval [CI], 2.4-3.4). The opioid intake significantly decreased at the 1-, 2-, and 3-month visits (P < 0.001, < 0.001, = 0.001 respectively), and there was significant improvement in sleep at the 1-, 2-, and 3-month visits (P < 0.001, < 0.001, = 0.001 respectively), and appetite and communication were significantly improved at the 1- and 2-month visits (all P < 0.001); all compared with baseline.
  
  
  
  MRI-guided CPN appears to be an effective and minimally invasive procedure for palliative pain management of pancreatic cancer. J. MAGN. RESON. IMAGING 2016;44:923-928.
authors.affiliation: Department of Medical Oncology, Fourth People's Hospital of Zibo City, The affiliated Hospital of Shandong Cancer Hospital and Institute, Zibo, China.
authors.forename: Shangang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Fourth People's Hospital of Zibo City, The affiliated Hospital of Shandong Cancer Hospital and Institute, Zibo, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of Medical Oncology, Shandong Cancer Hospital and Institute, Jinan, China.
authors.forename: Zengjun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Interventional MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, China.
authors.forename: Ruimei
authors.initials: R
authors.lastname: Ren
authors.affiliation: Department of Medical Oncology, Fourth People's Hospital of Zibo City, The affiliated Hospital of Shandong Cancer Hospital and Institute, Zibo, China.
authors.forename: Huaxu
authors.initials: H
authors.lastname: Zhai
authors.affiliation: Department of Interventional MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China. chenglilisd@sina.com.
authors.forename: Chengli
authors.initials: C
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000072716:Cancer Pain / Q000000981:diagnostic imaging* / Q000209:etiology / Q000517:prevention & control*; D002447:Celiac Plexus / Q000000981:diagnostic imaging* / Q000187:drug effects*; D000431:Ethanol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000009:adverse effects / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000431:Ethanol
keywords: celiac plexus neurolysis; ethanol; interventional MRI; pain; pancreatic cancer