title: Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases.
abstract: Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential therapeutic target for cerebrovascular diseases. This review summarizes the current evidence supporting the importance of CBF to cerebrovascular function, and the roles of NO and eNOS in CBF regulation.
authors.affiliation: State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P. R. China.|Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, P. R. China.
authors.forename: Jinqiang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, P. R. China.
authors.forename: Wanshan
authors.initials: W
authors.lastname: Song
authors.affiliation: State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P. R. China.|Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, P. R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P. R. China. fanxiang_78@hotmail.com.|Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, P. R. China. fanxiang_78@hotmail.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Fan
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000201:enzymology* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*
chemical_list: D052250:Nitric Oxide Synthase Type III
keywords: Cerebral blood flow; Cerebrovascular diseases; Endothelial nitric oxide synthase; Nitric oxide