title: Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties.
abstract: In the course of screening for new anti-influenza virus antibiotics, we isolated herquline A from a culture broth of the fungus, Penicillium herquei FKI-7215. Herquline A inhibited replication of influenza virus A/PR/8/34 strain in a dose-dependent manner without exhibiting cytotoxicity against several human cell lines. It did not inhibit the viral neuraminidase.
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Chiba
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.|b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Asami
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Suga
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.|b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nagai
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.|b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Momose
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.|b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.|b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Iwatsuki
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.|b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Yamada
authors.affiliation: b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ōmura
authors.affiliation: a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.|b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000502:physiology; D010407:Penicillium / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; C022235:herqueline
keywords: A/PR/8/34 strain; Penicillium herquei; herquline A; influenza virus