title: Design of Catalytic Peptides and Proteins Through Rational and Combinatorial Approaches.
abstract: This review focuses on recent progress in noncomputational methods to introduce catalytic function into proteins, peptides, and peptide assemblies. We discuss various approaches to creating catalytic activity and classification of noncomputational methods into rational and combinatorial classes. The section on rational design covers recent progress in the development of short peptides and oligomeric peptide assemblies for various natural and unnatural reactions. The section on combinatorial design describes recent advances in the discovery of catalytic peptides. We present the future prospects of these and other new approaches in a broader context, including implications for functional material design.
authors.affiliation: Department of Chemistry, City University of New York-Hunter College, New York, New York 10065; email: hmatsui@hunter.cuny.edu.|Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Maeda
authors.affiliation: Department of Chemistry, Syracuse University, Syracuse, New York 13244; email: ikorendo@syr.edu.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Makhlynets
authors.affiliation: Department of Chemistry, City University of New York-Hunter College, New York, New York 10065; email: hmatsui@hunter.cuny.edu.|Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsui
authors.affiliation: Department of Chemistry, Syracuse University, Syracuse, New York 13244; email: ikorendo@syr.edu.
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Korendovych
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004798:Enzymes / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis*; D015202:Protein Engineering / Q000379:methods*
chemical_list: D004798:Enzymes; D010455:Peptides
keywords: catalysis; metalloenzymes; phage display; protein design; supramolecular assemblies