title: The role of 18F-FDG PET/CT in infectious endocarditis: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To systematically review and conduct a meta-analysis of the available evidence for PET/CT using 18F-fluorodeoxyglucose as tracers in the imaging of infectious endocarditis (IE).
  
  
  METHODS
  Databases, including PubMed, Embase, and Web of Science, were searched for studies that examined the diagnostic value of 18F-FDG PET/CT for patients with IE. The reference lists following review articles and those of the included articles were checked to complement the electronic searches. The data extraction and methodological quality assessment were completed by two independent reviewers, and the meta-analysis was then conducted using Meta-Disc software, version 1.4.
  
  
  RESULTS
  A total of 6 studies involving 246 patients was included. The results of the meta-analysis indicated that the pooled sensitivity was 61% (95% confidence interval (CI), 52-88%), and the pooled specificity was 88% (95% CI, 80-93%). The positive likelihood ratio was 3.24 (95% CI, 1.67-6.28, p = 0.224), and the negative likelihood ratio was 0.50 (95% CI, 0.32-0.77, p = 0.015). The diagnostic odds ratio was 6.98 (95% CI, 2.55-19.10, p = 0.145), the overall area under the curve (AUC) was 0.8230 (SE = 0.1085), and the Q* value was 0.7563 (SE = 0.0979).
  
  
  CONCLUSIONS
  18F-FDG PET/CT is currently not sufficient for the diagnosis of IE because of its low sensitivity. However, 18F-FDG PET/CT might be a useful tool for the diagnosis of skin and pocket cardiovascular implantable electronic device (CIED) infections and prosthetic valve endocarditis (PVE).
authors.forename: Jinzhu
authors.initials: J
authors.lastname: Yan
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Yuming
authors.initials: Y
authors.lastname: Niu
authors.forename: Ruixia
authors.initials: R
authors.lastname: Yuan
authors.forename: Xiantao
authors.initials: X
authors.lastname: Zeng
authors.forename: Xingyao
authors.initials: X
authors.lastname: Ge
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Xinyu
authors.initials: X
authors.lastname: Peng
mesh_terms: D019540:Area Under Curve; D004696:Endocarditis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods*; D016017:Odds Ratio; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011379:Prognosis; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D012372:ROC Curve; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18