title: Inflammatory microenvironment and human papillomavirus-induced carcinogenesis.
abstract: More than 15% of the global cancer burden is attributable to infectious agents. Pathogens that cause persistent infections are strongly associated with cancer, inflammation being a major component of the chronic infections as revealed by basic, clinical and epidemiological studies. Persistent infection and viral oncoproteins induce specific cellular pathways modifications that promote tumorigenesis. Deregulated and continuous immune response leads to severe tissue and systemic damage, impaired tumor surveillance and consequent carcinogenesis promotion by selecting for metastatic and therapeutically resistant tumor phenotypes. In this review, the role of inflammatory microenvironment in the HPV-induced carcinogenesis is addressed, with a specific focus on the involvement of the immune molecules and microRNAs as well as their delivery through the microvesicle cargo.
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Mangino
authors.affiliation: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Maria Vincenza
authors.initials: MV
authors.lastname: Chiantore
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Iuliano
authors.affiliation: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy; Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche, Rome, Italy.
authors.forename: Gianna
authors.initials: G
authors.lastname: Fiorucci
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy; Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy; Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche, Rome, Italy. Electronic address: giovanna.romeo@uniroma1.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Romeo
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications*; D035683:MicroRNAs / Q000276:immunology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications*; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D035683:MicroRNAs
keywords: Cytokines/Chemokines; Inflammation; MicroRNAs; Microvesicles; Papillomavirus