title: Primary Neuroendocrine Carcinoma of the Middle Mediastinum Involving the Right Main Pulmonary Artery.
abstract: Primary neuroendocrine neoplasms of the mediastinum are extremely rare. We report the case of a 54-year-old woman who presented with dyspnea and was found to have a 6.8-cm tumor completely obliterating the right main pulmonary artery. Analysis of an endobronchial ultrasound fine-needle aspiration revealed a neuroendocrine tumor. A positron emission tomography scan showed no evidence of distant disease. The patient underwent surgical resection with reconstruction of the right main pulmonary artery with a Dacron (DuPont, Wilmington, DE) graft, followed by chemoradiotherapy. We discuss the presentation and management of this patient and review the current treatment options of primary neuroendocrine carcinomas of the mediastinum.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Albany Medical Center, Albany, New York. Electronic address: bakhosc@mail.amc.edu.
authors.forename: Charles T
authors.initials: CT
authors.lastname: Bakhos
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Albany Medical Center, Albany, New York.
authors.forename: Stephani C
authors.initials: SC
authors.lastname: Wang
authors.affiliation: New York Oncology Hematology PC, Amsterdam, New York.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Tedesco
authors.affiliation: New York Oncology Hematology PC, Amsterdam, New York.
authors.forename: Arsyl D
authors.initials: AD
authors.lastname: DeJesus
authors.affiliation: Department of Pathology, Albany Medical Center, Albany, New York.
authors.forename: Sahar
authors.initials: S
authors.lastname: Nozad
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Albany Medical Center, Albany, New York.
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Depan
mesh_terms: D044963:Biopsy, Fine-Needle; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D019160:Endosonography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D011651:Pulmonary Artery / Q000601:surgery*; D035583:Rare Diseases; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D014656:Vascular Surgical Procedures / Q000379:methods