title: Hashimoto's thyroiditis could be secondary to vitiligo: the possibility of antigen crossover and oxidative stress between the two diseases.
abstract: Autoimmune thyroid diseases (AITDs) are often accompanied by vitiligo, and the sera of patients with vitiligo often demonstrate increased frequencies of thyroid autoantibodies. In this study, we investigated the expression of melanocyte-associated antigens in tissues from patients with Hashimoto's thyroiditis (HT) without vitiligo using immunohistochemistry. Tissues of HT without vitiligo, as well as normal thyroid tissues, were both negative for the expression of NKI/beteb, gp100, tyrosinase-related protein 1 (TRP1), HMB-45 and S100, whereas they were positive for the expression of tyrosinase-related protein 2 (TRP2), lysosome-associated membrane protein 1 (LAMP1) and CD69. Tyrosinase (TYR) was only detected in tissues of HT, and levels of LAMP1 and CD69 were higher in tissues of HT than in normal thyroid tissues (p < 0.005). These results suggest the possibility of antigen crossover and oxidative stress between vitiligo and HT that might represent an immunological basis for secondary HT associated with vitiligo.
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, People's Republic of China.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, People's Republic of China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, People's Republic of China.
authors.forename: Qixing
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, People's Republic of China.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, People's Republic of China.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Song
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, People's Republic of China. luyan6289@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
mesh_terms: D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000032:analysis / Q000276:immunology*; D050031:Hashimoto Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D051907:Lysosomal Membrane Proteins / Q000378:metabolism; D008544:Melanocytes / Q000276:immunology*; D058950:Melanoma-Specific Antigens / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D009418:S100 Proteins / Q000378:metabolism; D013961:Thyroid Gland / Q000276:immunology*; D014357:Trypsin / Q000378:metabolism; D014362:Trypsinogen / Q000378:metabolism; D014820:Vitiligo / Q000276:immunology / Q000473:pathology*; D058951:gp100 Melanoma Antigen / Q000378:metabolism; D052118:Lysosomal-Associated Membrane Protein 1
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D051907:Lysosomal Membrane Proteins; D058950:Melanoma-Specific Antigens; D009418:S100 Proteins; D014357:Trypsin; D014362:Trypsinogen; D058951:gp100 Melanoma Antigen; C489116:LAMP1 protein, human; D052118:Lysosomal-Associated Membrane Protein 1; C548637:PMEL protein, human; C110294:S100A1 protein; C064831:PRSS2 protein, human; C489303:PRSS1 protein, human
keywords: Hashimoto’s thyroiditis; Immunohistochemistry; Melanocytes; Oxidative stress; Vitiligo