title: MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report.
abstract: Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm of chorionic-type intermediate trophoblasts, and it is most frequently located in the lower uterine segment and endocervix. Due to the epithelial-growth pattern with geographic necrosis exhibited by the neoplastic cells, ETT is commonly confused, both clinically and pathologically, with squamous cell carcinoma. Although there have been no previous reports of ETT focusing on computed tomography (CT) or magnetic resonance imaging (MRI) findings, we report a case of uterine ETT with special attention to the MRI findings referring to the pathological findings and MR images of previous reports. A 42-year-old Japanese woman (gravid 1, para 1) presented with uterus enlargement during screening, and complained of recent-onset lower abdominal pain. The MRI showed a solid tumor throughout the entire myometrium of the lower uterine segment, with the hemorrhagic cystic portion extending to the posterior subserosal space. Following hysterectomy, the final pathological diagnosis was ETT. An ETT is essentially a solid tumor composed of intermediate trophoblasts that exhibit an epithelial-like growth pattern and contain geographic necrosis with calcification. In our case, MRI revealed a non-specific-intensity solid tumor in the lower uterine segment with massive necrosis and hemorrhage extending to the subserosa. While it is difficult to distinguish between ETT and uterine carcinomas, recognition of certain tumor shapes and necrosis could enable more accurate diagnosis before treatment.
authors.affiliation: Department of Diagnostic Radiology, Yamagata University School of Medicine.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Kageyama
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kanoto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sugai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Suto
authors.forename: Satoru
authors.initials: S
authors.lastname: Nagase
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Osakabe
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D008175:Lung Neoplasms / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009215:Myometrium / Q000000981:diagnostic imaging; D009336:Necrosis; D014328:Trophoblastic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA