title: Specialization of biosynthetic membrane trafficking for neuronal form and function.
abstract: Neuronal growth and synaptic transmission require the continuous production of adhesion molecules, neurotransmitter receptors, ion-channels, and secreted trophic factors, and thus critically relies on the secretory pathway-the series of intracellular organelles including the endoplasmic reticulum (ER) and the Golgi apparatus (GA), where membrane lipids and proteins are synthesized. Commensurate with the gigantic size of the neuronal membrane and its compartmentalization by thousands of synapses with distinct compositions and activities, the neuronal secretory pathway has evolved to both traffic synaptic components over very long distances, and locally control the composition of specified segments of dendrites. Here we review new insights into the distribution and dynamics of dendritic secretory organelles and their impact on postsynaptic compartments.
authors.affiliation: Department of Synaptic Plasticity, Max Planck Institute for Brain Research, Frankfurt, Germany. Electronic address: cyril.hanus@brain.mpg.de.
authors.forename: Cyril
authors.initials: C
authors.lastname: Hanus
authors.affiliation: Neuroscience Research Unit, BioTherapeutics, Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA. Electronic address: michael.ehlers@pfizer.com.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Ehlers
mesh_terms: D000818:Animals; D003712:Dendrites / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D021381:Protein Transport; D055571:Secretory Pathway / Q000502:physiology*