title: Zinc delays the progression of obesity-related glomerulopathy in mice via down-regulating P38 MAPK-mediated inflammation.
abstract: Obesity, particularly child obesity, is one of the most common public health problems in the world and raises the risk of end-stage renal disease. Zinc (Zn) is essential for multiple organs in terms of normal structure and function; however, effects of Zn deficiency or supplementation among young individuals with obesity have not been well studied.
  
  
  
  Weaned mice were fed high-fat diets (HFD) with varied contents of Zn (Zn deficient, adequate, and supplemented) for 3 or 6 months. This study examined associations between renal pathogenesis and dietary Zn levels, specifically assessing inflammatory pathways by utilizing P38 MAPK inhibitor SB203580.
  
  
  
  HFD feeding induced typical syndromes of obesity-related renal disorders, which worsened by Zn marginal deficiency. The progression of obesity-related renal disorders was delayed by Zn supplementation. HFD induced renal inflammation, reflected by increased P38 MAPK phosphorylation along with increases of inflammatory cytokines MCP-1, IL-1β, IL-6, and TNF-α. P38 MAPK inhibition prevented renal pathological changes in mice fed with HFD and HFD/Zn deficiency.
  
  
  
  P38 MAPK mediated the renal inflammatory responses, which played a central role in the pathogenesis of HFD-induced renal disorders. Zn could delay the progression of obesity-related kidney disease by down-regulating P38 MAPK-mediated inflammation.
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China.|Department of Pediatrics, The University of Louisville, Kentucky, USA.
authors.forename: Manyu
authors.initials: M
authors.lastname: Luo
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Luo
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.|The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.|Department of Internal Medicine, The Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia, USA.
authors.forename: Kristen
authors.initials: K
authors.lastname: Payne
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.|Wendy L. Novak Diabetes Care Center, The University of Louisville School of Medicine, Kentucky, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Watson
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China.|Department of Pediatrics, The University of Louisville, Kentucky, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Yushuang
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.|The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Weixia
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Chemistry, The University of Louisville, Kentucky, USA.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Chemistry, The University of Louisville, Kentucky, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.|Wendy L. Novak Diabetes Care Center, The University of Louisville School of Medicine, Kentucky, USA.
authors.forename: Kupper
authors.initials: K
authors.lastname: Wintergerst
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Lining
authors.initials: L
authors.lastname: Miao
authors.affiliation: Department of Pediatrics, The University of Louisville, Kentucky, USA.|Wendy L. Novak Diabetes Care Center, The University of Louisville School of Medicine, Kentucky, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Cai
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003677:Deficiency Diseases / Q000178:diet therapy* / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D007249:Inflammation / Q000178:diet therapy* / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D007674:Kidney Diseases / Q000178:diet therapy* / Q000209:etiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D015032:Zinc / Q000172:deficiency* / Q000627:therapeutic use; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D048051:p38 Mitogen-Activated Protein Kinases; D015032:Zinc