title: A Prospective Study of Serotonin and Norepinephrine Transporter Genes and the Response to Desvenlafaxine Over 8 Weeks in Major Depressive Disorder.
abstract: No studies to date have evaluatedSLC6A2andSLC6A4genetic polymorphisms influencing antidepressant response to desvenlafaxine. We conducted an 8-week, open-label, prospective pilot study in 35 patients with major depressive disorder to assess the effects of genetic variations in SLC6A2 and SLC6A4 on both efficacy and side effect profile of desvenlafaxine. Results revealed that homozygotes for theSLC6A4HTTLPRSallele showed a 33% HDRS reduction compared to a 58% reduction for L allele carriers (p=0.037). No results survived adjustments for covariates or multiple comparisons. While these results need to be interpreted cautiously, they provide preliminary support for theSLC6A4HTTLPR polymorphism as potential modifier of desvenlafaxine efficacy.
authors.affiliation: Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne.
authors.forename: C H
authors.initials: CH
authors.lastname: Ng
authors.affiliation: Florey Institute for Neuroscience and Mental Health, Parkville, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Bousman
authors.affiliation: Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne.
authors.forename: D J
authors.initials: DJ
authors.lastname: Smith
authors.affiliation: Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne.
authors.forename: N
authors.initials: N
authors.lastname: Dowling
authors.affiliation: Healthscope Advanced Pathology, Melbourne, Victoria, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Byron
authors.affiliation: Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne.
authors.forename: J
authors.initials: J
authors.lastname: King
authors.affiliation: Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne.
authors.forename: J
authors.initials: J
authors.lastname: Sarris
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D000069468:Desvenlafaxine Succinate / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D010597:Pharmacogenetics; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D050484:Norepinephrine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D000069468:Desvenlafaxine Succinate