title: Secretin-enhanced Magnetic Resonance Cholangio-pancreatography in Pancreatic Insufficient and Pancreatic Sufficient Cystic Fibrosis Patients.
abstract: OBJECTIVE
  Although indirect methods of assessment of the exocrine pancreatic function have become the standard of care in the monitoring of pancreatic status, it still remains a current clinical challenge. Our aim was to compare the width of the pancreatic duct in pancreatic insufficient (PI) and pancreatic sufficient (PS) cystic fibrosis (CF) patients using secretin-enhanced magnetic resonance cholangiopancreatography (SE-MRCP).
  
  
  METHODS
  Thirty-seven CF patients were enrolled for this cross-sectional study, including 21 PI and 16 PS, all of whom underwent SE-MRCP. Measurement of the diameter of the pancreatic duct was performed in the head, body, and the tail of the pancreas at the baseline and after 1, 2, 3, 5, and 10 minutes after secretin administration.
  
  
  RESULTS
  The diameter of the pancreatic duct in the head of the pancreas after 5 and 10 minutes of secretin injection was greater in PI than in PS patients (median = 2.0 mm [interquartile range: 1.6-3.0] vs. 2.0 mm [1.0-2.0] and 2.0 mm [1.4-2.0] vs 1.0 mm [1.0-2.0], p=0.047 and p=0.040, respectively). Areas under ROC curves for discriminating between PI and PS patients were 0.693 (95% CI 0.521-0.866) and 0.698 (95% CI 0.528-0.868), respectively. No other differences in the width of the duct were identified at the baseline or during SE-MRCP.
  
  
  CONCLUSIONS
  The measurement of the diameter of the pancreatic duct during secretin stimulation does not allow for differentiating between PS and PI status in CF patients.
authors.affiliation: Department of Pediatric Radiology, Poznan, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jonczyk-Potoczna
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland.
authors.forename: Jan K
authors.initials: JK
authors.lastname: Nowak
authors.affiliation: Department of Physiology, Poznan, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Madry
authors.affiliation: Department of General Radiology, Poznan, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Katulska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Stezowska-Kubiak
authors.affiliation: Department of Computer Science and Statistics, Poznan, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Moczko
authors.affiliation: Department of Pulmonology, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Nowicka
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland. jarwalk@ump.edu.pl.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D000293:Adolescent; D000328:Adult; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D010188:Exocrine Pancreatic Insufficiency / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D012633:Secretin / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D012633:Secretin