title: Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial.
abstract: OBJECTIVE
  This study aimed to estimate the effectiveness of L-arginine for preventing preeclampsia in high-risk pregnancy.
  
  
  METHODS
  We performed a randomized, double-blind, placebo-controlled, clinical trial in patients with high-risk factors for preeclampsia. Fifty subjects received L-arginine, beginning from the 20th week of gestation. An additional 50 patients received homologated placebo.
  
  
  RESULTS
  The placebo group had a higher number of cases of preeclampsia (11/47) compared with the L-arginine group (3/49, P = 0.01). Birth weight was higher in the L-arginine group and there was a smaller number of preterm births (P = 0.03).
  
  
  CONCLUSIONS
  L-arginine is effective for preventing preeclampsia.
authors.affiliation: a Unidad de Investigación División de Ginecología y Obstetricia, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" , Guadalajara , Jalisco , Mexico.
authors.forename: E E
authors.initials: EE
authors.lastname: Camarena Pulido
authors.affiliation: b INTEC, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Jalisco, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: García Benavides
authors.affiliation: a Unidad de Investigación División de Ginecología y Obstetricia, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" , Guadalajara , Jalisco , Mexico.
authors.forename: J G
authors.initials: JG
authors.lastname: Panduro Barón
authors.affiliation: b INTEC, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Jalisco, Mexico.
authors.forename: S
authors.initials: S
authors.lastname: Pascoe Gonzalez
authors.affiliation: a Unidad de Investigación División de Ginecología y Obstetricia, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" , Guadalajara , Jalisco , Mexico.
authors.forename: A J
authors.initials: AJ
authors.lastname: Madrigal Saray
authors.affiliation: a Unidad de Investigación División de Ginecología y Obstetricia, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" , Guadalajara , Jalisco , Mexico.
authors.forename: F E
authors.initials: FE
authors.lastname: García Padilla
authors.affiliation: b INTEC, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Jalisco, Mexico.
authors.forename: S E
authors.initials: SE
authors.lastname: Totsuka Sutto
mesh_terms: D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001120:Arginine
keywords: Eclampsia; gestational hypertension; oxidative stress; preeclampsia; randomized controlled trial