title: An integrated text mining framework for metabolic interaction network reconstruction.
abstract: Text mining (TM) in the field of biology is fast becoming a routine analysis for the extraction and curation of biological entities (e.g., genes, proteins, simple chemicals) as well as their relationships. Due to the wide applicability of TM in situations involving complex relationships, it is valuable to apply TM to the extraction of metabolic interactions (i.e., enzyme and metabolite interactions) through metabolic events. Here we present an integrated TM framework containing two modules for the extraction of metabolic events (Metabolic Event Extraction module-MEE) and for the construction of a metabolic interaction network (Metabolic Interaction Network Reconstruction module-MINR). The proposed integrated TM framework performed well based on standard measures of recall, precision and F-score. Evaluation of the MEE module using the constructed Metabolic Entities (ME) corpus yielded F-scores of 59.15% and 48.59% for the detection of metabolic events for production and consumption, respectively. As for the testing of the entity tagger for Gene and Protein (GP) and metabolite with the test corpus, the obtained F-score was greater than 80% for the Superpathway of leucine, valine, and isoleucine biosynthesis. Mapping of enzyme and metabolite interactions through network reconstruction showed a fair performance for the MINR module on the test corpus with F-score >70%. Finally, an application of our integrated TM framework on a big-scale data (i.e., EcoCyc extraction data) for reconstructing a metabolic interaction network showed reasonable precisions at 69.93%, 70.63% and 46.71% for enzyme, metabolite and enzyme-metabolite interaction, respectively. This study presents the first open-source integrated TM framework for reconstructing a metabolic interaction network. This framework can be a powerful tool that helps biologists to extract metabolic events for further reconstruction of a metabolic interaction network. The ME corpus, test corpus, source code, and virtual machine image with pre-configured software are available at www.sbi.kmutt.ac.th/ preecha/metrecon.
authors.affiliation: Systems Biology and Bioinformatics Laboratory, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.|Center for Systems Biology, Soochow University, Suzhou, China.
authors.forename: Preecha
authors.initials: P
authors.lastname: Patumcharoenpol
authors.affiliation: School of Information Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
authors.forename: Narumol
authors.initials: N
authors.lastname: Doungpan
authors.affiliation: Systems Biology and Bioinformatics Laboratory, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.|Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
authors.forename: Asawin
authors.initials: A
authors.lastname: Meechai
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou, China.
authors.forename: Bairong
authors.initials: B
authors.lastname: Shen
authors.affiliation: Systems Biology and Bioinformatics Laboratory, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.|School of Information Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Chan
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou, China.|Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.
authors.forename: Wanwipa
authors.initials: W
authors.lastname: Vongsangnak
keywords: Corpus; Integrated framework; Metabolic entities; Metabolic interaction network; Text mining (TM)