title: Characterization and physiological effect of tapioca maltodextrin colloid plasma expander in hemorrhagic shock and resuscitation model.
abstract: Plasma expanders (PEs) are administered fluids to replace blood volume when massive blood loss has occured. Maltodextrin from tapioca starch was selected as a study candidate to prepare a colloid PE due to an uncomplicated production process. The formulations of mixture between tapioca maltodextrin and 0.9 % sodium chloride solution were prepared and then characterized. This was to investigate the effects of a dextrose equivalent (DE) and the concentration on the physical properties. Storage stability of each formulation was also determined and compared with clinically used PE [6 % hydroxyethyl starch (HES), 130/0.4]. The effects on the circulatory system in hamsters with hemorrhagic shock and resuscitation using prepared PE were also investigated. The results showed that low DE value led to high retrogradation, turbidity and viscosity but low colloid osmotic pressure and poor solubility. Among the prepared solutions, tapioca maltodextrin with DE6 at 10 % w/v concentration had comparable properties with 6 % HES 130/0.4. Animals resuscitated with 10 % DE6 PE had improved mean arterial blood pressure similar to those resuscitated with 6 % HES 130/0.4. However, several parameters in animals resuscitated with 10 % DE6 PE were lower than those resuscitated with 6 % HES 130/0.4, i.e., heart rate, functional capillary density. Therefore, if using tapioca maltodextrin for PE, some properties have to be considered and efficiently optimized.
authors.affiliation: Institute of Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, 6th floor, 100 year Building, Hatyai, Songkhla, 90110, Thailand. surapong.c@psu.ac.th.|Biological Materials for Medicine Research Unit, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand. surapong.c@psu.ac.th.
authors.forename: Surapong
authors.initials: S
authors.lastname: Chatpun
authors.affiliation: Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.|The Research and Training Center for Enhancing Quality of Life of Working-Age People, Khon Kaen University, Khon Kaen, 40002, Thailand.
authors.forename: Kittisak
authors.initials: K
authors.lastname: Sawanyawisuth
authors.affiliation: National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Klong Luang, Pathum Thani, 12120, Thailand.
authors.forename: Rungtiva
authors.initials: R
authors.lastname: Wansuksri
authors.affiliation: National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Klong Luang, Pathum Thani, 12120, Thailand.
authors.forename: Kuakoon
authors.initials: K
authors.lastname: Piyachomkwan
mesh_terms: D000818:Animals; D003102:Colloids / Q000737:chemistry*; D006224:Cricetinae; D004356:Drug Storage; D005440:Fluid Therapy; D018056:Hemorheology; D006863:Hydrogen-Ion Concentration; D006895:Hydroxyethyl Starch Derivatives / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D002365:Manihot / Q000737:chemistry*; D008647:Mesocricetus; D010952:Plasma Substitutes / Q000737:chemistry* / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry*; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000628:therapy*; D014783:Viscosity
chemical_list: D003102:Colloids; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D011134:Polysaccharides; C008315:maltodextrin