title: Copper-Catalyzed C(sp(2))-H Difluoroalkylation of Aldehyde Derived Hydrazones with Diboron as Reductant.
abstract: An efficient and general method for C(sp(2))-H difluoroalkylation of aldehyde derived hydrazones via a Cu(II)/B2pin2-catalyzed reaction between difluoroalkyl bromides and hydrazones was developed. In this reaction, both aromatic and aliphatic difluoroalkylated aldehyde derived hydrazones could be achieved in good to excellent yields. For some heteroaromatic aldehyde derived hydrazones, two fluoroacetates could be introduced onto the final products. A preliminary mechanism study manifested that a difluoroalkyl radical via SET pathway was involved in the reaction. In addition, the catalytic diboron reagent plays an indispensable role in this transformation.
authors.affiliation: Institute of Next Generation Matter Transformation, College of Chemical Engineering, College of Materials Science & Engineering, Huaqiao University , 668 Jimei Boulevard, Xiamen, Fujian 361021, People's Republic of China.
authors.forename: Miaolin
authors.initials: M
authors.lastname: Ke
authors.affiliation: Institute of Next Generation Matter Transformation, College of Chemical Engineering, College of Materials Science & Engineering, Huaqiao University , 668 Jimei Boulevard, Xiamen, Fujian 361021, People's Republic of China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Song