title: Glycemic Status in Organophosphorus Poisoning.
abstract: BACKGROUND
  Organophosphorus(OP) poisoning, in addition to its cholinergic manifestations shows metabolic derangements leading to hyperglycemia. Apart from inhibiting acetylcholinesterase it also induces oxidative stress to exhibit this manifestation. The present study aims to assess the glycemic status of OP poisoned patients and its association with various factors in OP poisoning like oxidative stress and dose of atropine.
  
  
  METHODS
  This is a prospective study which recruited 102 patients above 18 years of age with history of OP poisoning. They were categorized into 3 grades-mild, moderate and severe based on the Peradeniya Organophosphorus Poisining Scale. The routine biochemical parameters along with serum malondialdehyde (MDA) and cholinesterase were estimated in the study group.
  
  
  RESULTS
  Hyperglycemia and glycosuria were observed, with majority cases of hyperglycemia (57%) noticed in the severe group. There was a rise in the random plasma glucose (RPG), serum malondialdehyde (MDA), total dose of atropine across the groups along with a fall in the serum cholinesterase with increase in severity of poisoning. The fall in plasma glucose at the time of discharge was significant in all three groups when compared to the admission random plasma glucose(RPG) level. This transient hyperglycemia exhibited a significant positive association with serum MDA and dose of atropine administered during treatment (p<0.05).
  
  
  CONCLUSIONS
  Glycemic status in OP poisoning may play a role in identifying the severity of poisoning at the time of admission.
authors.affiliation: Department of Biochemistry and Medicine, SCB Medical College, Cuttack, Odisha, India.
authors.forename: S
authors.initials: S
authors.lastname: Panda
authors.affiliation: Department of Biochemistry, AIIMS, Raipur, Chhattisgarh, India.
authors.forename: R
authors.initials: R
authors.lastname: Nanda
authors.affiliation: Department of Biochemistry, AIIMS, Bhubaneswar, Odisha, India.
authors.forename: M
authors.initials: M
authors.lastname: Mangaraj
authors.affiliation: Department of Biochemistry and Medicine, SCB Medical College, Cuttack, Odisha, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Rathod
authors.affiliation: Department of Biochemistry and Medicine, SCB Medical College, Cuttack, Odisha, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Mishra
mesh_terms: D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis*; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007194:India; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D062025:Organophosphate Poisoning / Q000188:drug therapy; D018384:Oxidative Stress; D011446:Prospective Studies
chemical_list: D000931:Antidotes; D001786:Blood Glucose; D008315:Malondialdehyde; D001285:Atropine; D002802:Cholinesterases
keywords: Atropine; hyperglycemia; organophosphorus; oxidative stress; random plasma glucose.