title: Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus.
abstract: Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PdCV) cause indistinguishable clinical signs and pathological changes in swine. Here we investigated the antigenic relationship between PEDV and PdCV. We provide the first evidence that conserved epitope(s) on the respective viral nucleocapsid proteins cross-react with each other although virus neutralization cross-reactivity was not observed. As a practical matter, prevention of these two very similar diseases of swine will require the development of separate virus-specific vaccine products.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address: ma.194@osu.edu.
authors.forename: Yuanmei
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Xueya
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Oglesbee
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Krakowka
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Niehaus
authors.affiliation: Guangdong Haid Institute of Animal Husbandry & Veterinary, PanYu, Guangdong 511400, PR China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Wang
authors.affiliation: Guangdong Haid Institute of Animal Husbandry & Veterinary, PanYu, Guangdong 511400, PR China.
authors.forename: Aiqing
authors.initials: A
authors.lastname: Jia
authors.affiliation: College of Animal Science and Technology, Zhejiang Agriculture and Forestry University, Lin-An, Zhejiang 311300, PR China.
authors.forename: Houhui
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address: li.926@osu.edu.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002460:Cell Line; D017934:Coronavirus / Q000276:immunology*; D018352:Coronavirus Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D003429:Cross Reactions / Q000276:immunology; D007422:Intestines / Q000276:immunology / Q000821:virology; D019590:Nucleocapsid Proteins / Q000235:genetics / Q000276:immunology; D053485:Porcine epidemic diarrhea virus / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000821:virology*; D014709:Vero Cells
chemical_list: D000914:Antibodies, Viral; D019590:Nucleocapsid Proteins