title: GESTATIONAL DIABETES MELLITUS SEEMS TO BE ASSOCIATED WITH INFLAMMATION.
abstract: The aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like pro- tein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 pregnant women with GDM and 29 pregnant women with normal glucose tolerance matched for age (± 2 years) and pre-pregnancy body mass index (± 2 kg/m²). The YKL-40/CHI3L1 levels were measured, and NLR and PLR investigated. There were no statisti- cally significant differences in maternal age, gestational age, gravidity and parity. Higher YKL-40 levels were recorded in pregnant women with GDM compared to control subjects (203 (65-300) ng/ mL vs. 159.2 (14-290) ng/mL, p = 0.007). NLR and PLR were significantly higher in GDM com- pared with control group. In conclusion, GDM is associated with high levels of YKL-40, NLR and PLR, which indicate inflammatory status.
authors.forename: Ayla
authors.initials: A
authors.lastname: Aktulay
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustun
authors.forename: Mehmet Sahin
authors.initials: MS
authors.lastname: Ozkan
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kara
authors.forename: Oktay
authors.initials: O
authors.lastname: Kaymak
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D016640:Diabetes, Gestational / Q000097:blood* / Q000276:immunology; D005260:Female; D005951:Glucose Tolerance Test; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D011247:Pregnancy; D055815:Young Adult
chemical_list: D054392:Adipokines; D001786:Blood Glucose; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins