title: Periodontal regeneration with 0.3% basic fibroblast growth factor (FGF-2) for a patient with aggressive periodontitis: a case report.
abstract: This case report describes the clinical efficacy of treatment with basic fibroblast growth factor (FGF-2) for periodontal regeneration. A patient with aggressive periodontitis participated in a clinical trial involving administration of 0.3% FGF-2 in comparison with a placebo control. To evaluate the efficacy of FGF-2, standardized radiographs were taken before surgery and at 12, 24, and 36 weeks after FGF-2 treatment. The rate of increase in alveolar bone height was 86.9% at 36 weeks. The 6-year postoperative radiograph showed significant development of alveolar bone in comparison with the first visit. FGF-2 treatment may be effective for periodontal regeneration in cases of aggressive periodontitis. (J Oral Sci 58, 137-140, 2016).
authors.affiliation: Department of Periodontology, Nihon University School of Dentistry.
authors.forename: Naoto
authors.initials: N
authors.lastname: Yoshinuma
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Koshi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Masataka
authors.initials: M
authors.lastname: Idesawa
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sugano
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D010919:Placebos; D012038:Regeneration
chemical_list: D010919:Placebos; D016222:Fibroblast Growth Factor 2