title: UCH-L1 in DLBCL: marker or target?
abstract: In this issue of Blood, Bedekovics et al have demonstrated that a multifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in diffuse large B-cell lymphomas (DLBCLs), and that levels of this molecule are higher in germinal center (GC) B-cell DLBCL (GCB-DLBCL) compared with activated B-cell DLBCL (ABC-DLBCL) and predict poor outcomes.
authors.affiliation: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Pagano
authors.affiliation: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL.
authors.forename: Julia
authors.initials: J
authors.lastname: Shackelford
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D018858:Germinal Center / Q000473:pathology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D043222:Ubiquitin Thiolesterase / Q000235:genetics*
chemical_list: D043222:Ubiquitin Thiolesterase