title: The Effect of Roux-en-Y vs. Omega-Loop Gastric Bypass on Liver, Metabolic Parameters, and Weight Loss.
abstract: Omega-loop gastric bypass (OLGB) results in weight loss (WL) but data on its impact on liver and glucose metabolism compared to Roux-en-Y gastric bypass (RYGB) is lacking. Therefore, the aim of this study was to compare the development of hepatic and metabolic markers as well as WL between the above-mentioned surgical groups during the first postoperative year.
  
  
  
  We retrospectively evaluated the respective parameters in non-diabetic morbidly obese patients who underwent either RYGB (n = 25) or OLGB (n = 25).
  
  
  
  Compared to RYGB, OLGB showed a greater WL percentage. Liver transaminases dropped in RYGB, while rose in OLGB. No correlation between aspartate transaminase, alanine transaminase, and WL could be detected. Gamma-glutamyltransferase decreased significantly in RYGB over the first 3 months, while it increased in OLGB. We found higher levels of triglycerides, insulin, homeostasis model assessment of insulin resistance (HOMA2-IR), and liver fat percentage in RYGB at baseline, despite matching the groups for age, sex, and BMI. Those differences disappeared, except for triglycerides, within 1 year. All metabolic parameters correlated with WL.
  
  
  
  OLGB results in greater WL but transiently deteriorated several liver parameters in the first postoperative year. This was not associated with WL. The impact of these results on hepatic outcomes such as non-alcoholic steatohepatitis and fibrosis progression requires further studies. In both groups, improved insulin resistance and sensitivity were correlated with higher WL and lower liver fat percentage, respectively.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. renate@kruschitz.de.|Department of Internal Medicine I with Diabetology, Endocrinology and Nephrology Rudolfstiftung Hospital, Karl Landsteiner Institute for Obesity and Metabolic Diseases, Vienna, Austria. renate@kruschitz.de.
authors.forename: Renate
authors.initials: R
authors.lastname: Kruschitz
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.|Special Institute for Preventive Cardiology And Nutrition - SIPCAN save your life, Salzburg, Austria.
authors.forename: Maria
authors.initials: M
authors.lastname: Luger
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Kienbacher
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Trauner
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Carmen
authors.initials: C
authors.lastname: Klammer
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Karin
authors.initials: K
authors.lastname: Schindler
authors.affiliation: Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
authors.forename: Felix B
authors.initials: FB
authors.lastname: Langer
authors.affiliation: Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Prager
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Krebs
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.|Department of Internal Medicine I with Diabetology, Endocrinology and Nephrology Rudolfstiftung Hospital, Karl Landsteiner Institute for Obesity and Metabolic Diseases, Vienna, Austria.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ludvik
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D015390:Gastric Bypass / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009767:Obesity, Morbid / Q000453:epidemiology / Q000601:surgery; D012189:Retrospective Studies; D014280:Triglycerides / Q000032:analysis; D015431:Weight Loss / Q000502:physiology*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D005723:gamma-Glutamyltransferase
keywords: Gastric bypass; Liver parameters; Metabolic parameters; Morbid obesity; Weight loss