title: Spotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity.
abstract: Poststroke spasticity affects up to one-half of stroke patients and has debilitating effects, contributing to diminished activities of daily living, quality of life, pain, and functional impairments. Botulinum toxin (BoNT) is proven to be safe and effective in the treatment of focal poststroke spasticity. The aim of this review is to highlight BoNT and its potential in the treatment of upper and lower limb poststroke spasticity. We review evidence for the efficacy of BoNT type A and B formulations and address considerations of optimal injection technique, patient and caregiver satisfaction, and potential adverse effects of BoNT.
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Kaku
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Simpson
mesh_terms: D000818:Animals; D001905:Botulinum Toxins / Q000627:therapeutic use*; D006801:Humans; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology*; D020521:Stroke / Q000150:complications* / Q000188:drug therapy*
chemical_list: D001905:Botulinum Toxins
keywords: botulinum toxin; incobotulinumtoxinA; onabotulinumtoxinA; poststroke spasticity; rimabotulinumtoxinB