title: Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts.
abstract: The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.
authors.affiliation: Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney 2006, New South Wales, Australia. markus.muellner@sydney.edu.au.
authors.forename: Markus
authors.initials: M
authors.lastname: Müllner
authors.affiliation: Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia and ARC Centre for Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.
authors.forename: Dharmini
authors.initials: D
authors.lastname: Mehta
authors.affiliation: Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.
authors.forename: Cameron J
authors.initials: CJ
authors.lastname: Nowell
authors.affiliation: Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia and ARC Centre for Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.
authors.forename: Christopher J H
authors.initials: CJ
authors.lastname: Porter
mesh_terms: D000818:Animals; D051379:Mice; D008819:Mice, Nude; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000737:chemistry / Q000378:metabolism; D010316:Particle Size; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D013499:Surface Properties; D014018:Tissue Distribution
chemical_list: D011108:Polymers