title: A Review on the Respiratory System Toxicity of Carbon Nanoparticles.
abstract: The respiratory system represents the main gateway for nanoparticles' entry into the human body. Although there is a myriad of engineered nanoparticles, carbon nanoparticles/nanotubes (CNPs/CNTs) have received much attention mainly due to their light weight, very high surface area, durability, and their diverse applications. Since their discovery and manufacture over two decades ago, much has been learned about nanoparticles' interactions with diverse biological system models. In particular, the respiratory system has been of great interest because various natural and man-made fibrous particles are known to be responsible for chronic and debilitating lung diseases. In this review, we present up-to-date the literature regarding the effects of CNTs or carbon nanofibers (CNFs) on the human respiratory system with respect to respiratory toxicity pathways and associated pathologies. This article is intended to emphasize the potentially dangerous effects to the human respiratory system if inadequate measures are used in the manufacture, handling, and preparation and applications of CNP or CNP-based products.
authors.affiliation: Biology Department, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS 39217, USA. maricica.pacurari@jsums.edu.|Research Center in Minority Institutions-Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS 39217, USA. maricica.pacurari@jsums.edu.
authors.forename: Maricica
authors.initials: M
authors.lastname: Pacurari
authors.affiliation: Biology Department, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA. Kristine.Lowe@utrgv.edu.
authors.forename: Kristine
authors.initials: K
authors.lastname: Lowe
authors.affiliation: Biology Department, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS 39217, USA. paul.b.tchounwou@jsums.edu.|Research Center in Minority Institutions-Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS 39217, USA. paul.b.tchounwou@jsums.edu.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Tchounwou
authors.affiliation: Biology Department, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS 39217, USA. ramzi.kafoury@jsums.edu.|Research Center in Minority Institutions-Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS 39217, USA. ramzi.kafoury@jsums.edu.
authors.forename: Ramzi
authors.initials: R
authors.lastname: Kafoury
mesh_terms: D006801:Humans; D057139:Nanofibers / Q000633:toxicity*; D053758:Nanoparticles / Q000633:toxicity*; D037742:Nanotubes, Carbon / Q000633:toxicity*; D012137:Respiratory System / Q000187:drug effects*
chemical_list: D037742:Nanotubes, Carbon
keywords: CNF; CNT; exposure levels; respiratory pathology; toxicological pathways