title: Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs.
abstract: Accelerated radiation therapy protocols address the specific biology of aggressive oropharyngeal squamous cell carcinoma and this approach was applied in 5 feline and 3 canine oropharyngeal squamous cell carcinoma patients where surgery was not possible (4/5 feline and 2/3 canine cases) or was declined (1/5 feline and 1/3 canine cases). A protocol using 14 fractions of 3.5 Gy over 9-days, combined with carboplatin chemotherapy as a radiosensitiser (total dose 180 mg/m2 in feline and 300 mg/m2 in canine cases) resulted in a complete tumor response in most cases (4/5 feline and 3/3 canine cases) with acceptable acute and long-term side effects. Results achieved in feline cases correspond with published data where these specific radiotherapy protocols were employed. A complete response and long-term survival (> 2-years) was achieved in all canine patients. Although no standardized chemoradiotherapy protocols currently exist, this therapeutic approach can be a useful addition for the management of oropharyngeal squamous cell carcinoma of cats and dogs when the goals of treatment include maximizing tumor control while maintaining function and quality of life.
authors.forename: Ana
authors.initials: A
authors.lastname: Rejec
authors.forename: Jerome
authors.initials: J
authors.lastname: Benoit
authors.forename: Cedric
authors.initials: C
authors.lastname: Tutt
authors.forename: David
authors.initials: D
authors.lastname: Crossley
authors.forename: Janos
authors.initials: J
authors.lastname: Butinar
authors.forename: Natasa Ihan
authors.initials: NI
authors.lastname: Hren
mesh_terms: D000818:Animals; D016190:Carboplatin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000662:veterinary*; D002371:Cat Diseases / Q000532:radiotherapy*; D002415:Cats; D059248:Chemoradiotherapy / Q000592:standards / Q000662:veterinary*; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy / Q000662:veterinary*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
chemical_list: D011838:Radiation-Sensitizing Agents; D016190:Carboplatin