title: Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats.
abstract: The use of natural substances and micronutritional approaches has been suggested as a therapeutic alternative to benefit the bone healing associated with no side effects. Nevertheless, the influence of micronutritional interventions with therapeutic proprieties on the bone repair has yet to be intensely evaluated, and no evidence is available exploring the impact of micronutrient supplementation on the peri-implant bone healing.
  
  
  OBJECTIVE
  This study investigated the effect of micronutrients supplementation on the bone repair around implants.
  
  
  METHODS
  One screw-shaped titanium implant was inserted in each tibia of each rat, which were assigned to: daily administration, for 30 d, of the placebo solution (Placebo group-n:18) or micronutrients supplementation (Micronutrients group-n:18), based on calcium, magnesium, zinc, and vitamin D3 intake. After, the animals were sacrificed. One of the implants was removed by applying a counter-torque force to evaluate the force to rupture the bone-implant interface. The other implant was evaluated by microcomputed tomography (CT) examination to determine the bone-to-implant contact (BIC) and the bone volume (BV/TV).
  
  
  RESULTS
  No statistically significant differences were observed between the groups for both counter-torque values and microCT parameters (p>0.05).
  
  
  CONCLUSIONS
  Within the limits of this study, micronutrients supplementation did not provide additional benefits to the bone healing around dental implants.
authors.affiliation: Faculdade de Odontologia, Universidade Paulista, São Paulo, SP, Brasil.
authors.forename: Suzana Peres
authors.initials: SP
authors.lastname: Pimentel
authors.affiliation: Faculdade de Odontologia, Universidade Paulista, São Paulo, SP, Brasil.
authors.forename: Renato Correa
authors.initials: RC
authors.lastname: Casarin
authors.affiliation: Faculdade de Odontologia, Universidade Paulista, São Paulo, SP, Brasil.
authors.forename: Fernanda Vieira
authors.initials: FV
authors.lastname: Ribeiro
authors.affiliation: Faculdade de Odontologia, Universidade Paulista, São Paulo, SP, Brasil.
authors.forename: Fabiano Ribeiro
authors.initials: FR
authors.lastname: Cirano
authors.affiliation: Departamento de Radiologia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, SP, Brasil.
authors.forename: Karla
authors.initials: K
authors.lastname: Rovaris
authors.affiliation: Departamento de Radiologia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, SP, Brasil.
authors.forename: Francisco
authors.initials: F
authors.lastname: Haiter Neto
authors.affiliation: Faculdade de Odontologia, Universidade Paulista, São Paulo, SP, Brasil.
authors.forename: Marcio Zaffalon
authors.initials: MZ
authors.lastname: Casati
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D001863:Bone Screws; D000069343:Bone-Implant Interface; D002118:Calcium / Q000494:pharmacology; D002762:Cholecalciferol / Q000494:pharmacology; D003758:Dental Implantation, Endosseous / Q000379:methods*; D019587:Dietary Supplements; D017102:Fracture Healing / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D018977:Micronutrients / Q000494:pharmacology*; D015990:Placebo Effect; D017208:Rats, Wistar; D013977:Tibia / Q000187:drug effects; D014025:Titanium; D019415:Torque; D016896:Treatment Outcome; D055114:X-Ray Microtomography; D015032:Zinc / Q000494:pharmacology
chemical_list: D018977:Micronutrients; D002762:Cholecalciferol; D014025:Titanium; D008274:Magnesium; D015032:Zinc; D002118:Calcium