title: Optical Coherence Tomography Angiography Features of Type 3 Neovascularization in Age-Related Macular Degeneration.
abstract: OBJECTIVE
  To characterize the imaging features of type 3 neovascularization secondary to exudative age-related macular degeneration on optical coherence tomography (OCT) angiography (OCTA).
  
  
  METHODS
  Patients diagnosed with treatment-naïve early-stage type 3 neovascularization underwent multimodal imaging, including color retinal photography or multicolor imaging, fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCTA. The OCTA features of type 3 neovascularization were analyzed and correlated with the findings on angiography and spectral-domain OCT.
  
  
  RESULTS
  OCTA showed lesions characterized by a retinal-retinal anastomosis. These lesions emerged from the deep capillary plexus and formed a clear, tuft-shaped, high-flow network in the outer retinal segment in all eyes, abutting in the subretinal pigment epithelium space. In most cases, a small, clew-like lesion was present in the choriocapillaris segment. Moreover, in some cases, this clew-like lesion seemed to be connected to the choroid through a small-caliber vessel.
  
  
  CONCLUSIONS
  OCTA of treatment-naïve type 3 neovascularization shows high-flow, tuft-shaped, abnormal outer retinal proliferation that is almost consistently associated with a small, clew-like lesion in the choriocapillaris layer.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Alexandra
authors.initials: A
authors.lastname: Miere
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000379:methods*; D002829:Choroid / Q000098:blood supply / Q000000981:diagnostic imaging*; D020256:Choroidal Neovascularization / Q000145:classification / Q000000981:diagnostic imaging*; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D012171:Retinal Vessels / Q000000981:diagnostic imaging* / Q000502:physiology; D041623:Tomography, Optical Coherence / Q000379:methods*; D057135:Wet Macular Degeneration / Q000145:classification / Q000000981:diagnostic imaging*