title: [SEX HORMONE INFLUENCE ON PERIPHERAL NATURAL KILLER CELLS COUNT].
abstract: Proper evaluation of immunological factors connected with pregnancy establishment increased the possibility for exact treatment in high risk gestation cases. Hormonal changes during an ovarian cycle may affect immune response, which is crucial for the embryonic implantation. Peripheral Natural killer (pNK) cells are key components of immune systems and their activities could be regulated by sex hormones. In the present study we investigated the effects of estrogen fluctuation on the number of NK cells in vivo during the early follicular and middle luteal phase of menstrual cycle. In 63 healthy women with at least one full term pregnancy and regular menstrual cycle with duration between 24 and 32 days, blood samples have been collected twice for investigation of CD3/CD16/CD56 positive lymphocytes. The mean pNK count in follicular phase was 11.6% with 4.7% variation. The median was 10.6%. The mean pNK count in luteal phase was 12.1% with 5.1% variation, respectively median for cell number 11.8%. The two-tailed t-test comparison did not find any statistical difference despite the slight elevation of pNK cells count in luteal phase. The insignificant variation in pNK cells count objected the suggestion to evaluate immunological status in women with adverse pregnancy outcome in specific phase of menstrual cycle.
authors.forename: P
authors.initials: P
authors.lastname: Ivanov
authors.forename: E
authors.initials: E
authors.lastname: Konova
authors.forename: Sv
authors.initials: S
authors.lastname: Blajeva
authors.forename: Tsv
authors.initials: T
authors.lastname: Lukanov
authors.forename: P
authors.initials: P
authors.lastname: Angelova
authors.forename: V
authors.initials: V
authors.lastname: Georgieva
authors.forename: V
authors.initials: V
authors.lastname: Totev
authors.forename: R
authors.initials: R
authors.lastname: Komsa-Penkova
mesh_terms: D000328:Adult; D017252:CD3 Complex / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D010064:Embryo Implantation; D004967:Estrogens / Q000276:immunology*; D005260:Female; D005498:Follicular Phase; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology; D008183:Luteal Phase; D018655:Lymphocyte Count; D011247:Pregnancy; D017452:Receptors, IgG / Q000032:analysis; D055815:Young Adult
chemical_list: D017252:CD3 Complex; D019002:CD56 Antigen; D004967:Estrogens; D017452:Receptors, IgG