title: Hydrogen Sulfide in Renal Physiology and Disease.
abstract: Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis. Recent Advances: The aim of this review is to critically evaluate the evidence for a role for H2S in kidney function and disease.
  
  
  
  H2S regulates fundamental kidney physiologic processes such as glomerular filtration and sodium reabsorption. In kidney disease states H2S appears to play a complex role in a context-dependent manner. In some disease states such as ischemia-reperfusion and diabetic kidney disease it can serve as an agent that ameliorates kidney injury. In other diseases such as cis-platinum-induced kidney disease it may mediate kidney injury although more investigation is needed. Recent studies have revealed that the actions of nitric oxide and H2S may be integrated in kidney cells.
  
  
  
  Further studies are needed to understand the full impact of H2S on kidney physiology. As it is endowed with the properties of regulating blood flow, oxidative stress, and inflammation, H2S should be investigated for its role in inflammatory and toxic diseases of the kidney. Such in-depth exploration may identify specific kidney diseases in which H2S may constitute a unique target for therapeutic intervention. Antioxid. Redox Signal. 25, 720-731.
authors.affiliation: 1 Division of Nephrology, Department of Medicine, University of Texas Health Science Center , San Antonio, Texas.
authors.forename: Denis
authors.initials: D
authors.lastname: Feliers
authors.affiliation: 1 Division of Nephrology, Department of Medicine, University of Texas Health Science Center , San Antonio, Texas.|2 South Texas Veterans Healthcare System , San Antonio, Texas.
authors.forename: Hak Joo
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: 1 Division of Nephrology, Department of Medicine, University of Texas Health Science Center , San Antonio, Texas.|2 South Texas Veterans Healthcare System , San Antonio, Texas.
authors.forename: Balakuntalam S
authors.initials: BS
authors.lastname: Kasinath
mesh_terms: D000818:Animals; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D007674:Kidney Diseases / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D009569:Nitric Oxide; D006862:Hydrogen Sulfide
keywords: acute kidney injury; chronic kidney disease; diabetic kidney disease; hypertension; renal physiology