title: Interleukin 8 Gene Polymorphisms Are Not Associated with Tuberculosis Susceptibility in the Chinese Population.
abstract: Interleukin 8 (IL8) is an important chemokine that elicits host immune response against tuberculosis (TB). However, whether there is an association between IL8 gene polymorphism and TB susceptibility in the Chinese population is unknown. IL8 gene was amplified and sequenced to search for nucleotide polymorphisms among the Chinese population. Four single nucleotide polymorphisms (SNPs) were identified, selected, and analyzed in a cohort of 438 patients with TB and 536 healthy controls. Allelic, genotypic, and haplotypic analysis demonstrated that the distribution of the four IL8 SNPs between patients with TB and healthy controls was not significantly different (P>0.05). The four IL8 SNPs detected in this study were not associated with TB susceptibility in the Chinese population. Secretion of IL8 by peripheral blood cells was greatly stimulated upon exposure to Mycobacterium tuberculosis whole cell extract, but such enhanced secretion was not associated with the IL8 rs4073 alleles.
authors.affiliation: Center office, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing 101149, China; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Clinical Center on Tuberculosis, China CDC, Beijing 101149, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Center office, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing 101149, China; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Clinical Center on Tuberculosis, China CDC, Beijing 101149, China.
authors.forename: Yu Hong
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Beijing Changping Center for Tuberculosis Control and Prevention, Beijing 102200, China.
authors.forename: Zhi Guo
authors.initials: ZG
authors.lastname: Zhang
authors.affiliation: Beijing Changping Center for Tuberculosis Control and Prevention, Beijing 102200, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Beijing Changping Center for Tuberculosis Control and Prevention, Beijing 102200, China.
authors.forename: Xiao Wei
authors.initials: XW
authors.lastname: Yang
authors.affiliation: Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Chuan You
authors.initials: CY
authors.lastname: Li
authors.affiliation: Department of Pathology, Beijing Tuberculosis & Thoracic Tumor Research Institute; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Nan Ying
authors.initials: NY
authors.lastname: Che
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D020022:Genetic Predisposition to Disease; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000235:genetics*
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8