title: Tet proteins enhance the developmental hourglass.
abstract: A new study compares DNA methylation profiles in developing zebrafish, Xenopus tropicalis and mice and suggests roles for Tet proteins in demethylating conserved gene enhancers during the phylotypic period of early development. These findings provide an epigenetic underpinning for the 'hourglass' model.
authors.affiliation: Howard Hughes Medical Institute and the Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Hendrickson
authors.affiliation: Howard Hughes Medical Institute and the Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
authors.forename: Bradley R
authors.initials: BR
authors.lastname: Cairns
mesh_terms: D000818:Animals; D019175:DNA Methylation; D004742:Enhancer Elements, Genetic