title: The Effect of Intravenous Citalopram on the Neural Substrates of Obsessive-Compulsive Disorder.
abstract: This study investigated the effect of an intravenous serotonin reuptake inhibitor on the neural substrates of obsessive-compulsive disorder (OCD), as intravenous agents may be more effective in treating OCD than conventional oral pharmacotherapy. Eight OCD subjects and eight control subjects received alternate infusions of citalopram and placebo during functional magnetic resonance imaging, in a randomized, symptom-provocation, crossover design. Compared with baseline, OCD subjects displayed significant changes in prefrontal neural activity after the citalopram infusion relative to placebo, and these changes correlated with reductions in subjective anxiety.
authors.affiliation: From the University of Toronto, Toronto, Canada (TPB, NASF, LNR, DKC, BGP, AVR); the Centre for Addiction and Mental Health, Toronto (TPB, LNR, YGP); the Campbell Research Institute, Toronto (BGP, AVR); the Rotman Research Institute, Toronto (NASF); and the Baycrest Centre for Geriatric Care, Toronto (DKC).
authors.forename: Tracy P
authors.initials: TP
authors.lastname: Bhikram
authors.affiliation: From the University of Toronto, Toronto, Canada (TPB, NASF, LNR, DKC, BGP, AVR); the Centre for Addiction and Mental Health, Toronto (TPB, LNR, YGP); the Campbell Research Institute, Toronto (BGP, AVR); the Rotman Research Institute, Toronto (NASF); and the Baycrest Centre for Geriatric Care, Toronto (DKC).
authors.forename: Norman A S
authors.initials: NA
authors.lastname: Farb
authors.affiliation: From the University of Toronto, Toronto, Canada (TPB, NASF, LNR, DKC, BGP, AVR); the Centre for Addiction and Mental Health, Toronto (TPB, LNR, YGP); the Campbell Research Institute, Toronto (BGP, AVR); the Rotman Research Institute, Toronto (NASF); and the Baycrest Centre for Geriatric Care, Toronto (DKC).
authors.forename: Lakshmi N
authors.initials: LN
authors.lastname: Ravindran
authors.affiliation: From the University of Toronto, Toronto, Canada (TPB, NASF, LNR, DKC, BGP, AVR); the Centre for Addiction and Mental Health, Toronto (TPB, LNR, YGP); the Campbell Research Institute, Toronto (BGP, AVR); the Rotman Research Institute, Toronto (NASF); and the Baycrest Centre for Geriatric Care, Toronto (DKC).
authors.forename: Yousef G
authors.initials: YG
authors.lastname: Papadopoulos
authors.affiliation: From the University of Toronto, Toronto, Canada (TPB, NASF, LNR, DKC, BGP, AVR); the Centre for Addiction and Mental Health, Toronto (TPB, LNR, YGP); the Campbell Research Institute, Toronto (BGP, AVR); the Rotman Research Institute, Toronto (NASF); and the Baycrest Centre for Geriatric Care, Toronto (DKC).
authors.forename: David K
authors.initials: DK
authors.lastname: Conn
authors.affiliation: From the University of Toronto, Toronto, Canada (TPB, NASF, LNR, DKC, BGP, AVR); the Centre for Addiction and Mental Health, Toronto (TPB, LNR, YGP); the Campbell Research Institute, Toronto (BGP, AVR); the Rotman Research Institute, Toronto (NASF); and the Baycrest Centre for Geriatric Care, Toronto (DKC).
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Pollock
authors.affiliation: From the University of Toronto, Toronto, Canada (TPB, NASF, LNR, DKC, BGP, AVR); the Centre for Addiction and Mental Health, Toronto (TPB, LNR, YGP); the Campbell Research Institute, Toronto (BGP, AVR); the Rotman Research Institute, Toronto (NASF); and the Baycrest Centre for Geriatric Care, Toronto (DKC).
authors.forename: Arun V
authors.initials: AV
authors.lastname: Ravindran
mesh_terms: D061605:Administration, Intravenous / Q000379:methods; D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects*; D001931:Brain Mapping; D015283:Citalopram / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors