title: Patients' perceived utility of whole-genome sequencing for their healthcare: findings from the MedSeq project.
abstract: OBJECTIVE
  To evaluate patients' expectations regarding the perceived utility of whole-genome sequencing (WGS).
  
  
  METHODS
  We used latent class analysis to characterize individuals enrolled in the MedSeq Project based on their perceived utility of WGS. Multinomial logistic regression was used to evaluate associations between participant characteristics and latent classes.
  
  
  RESULTS
  Findings characterized participants into one of three perceived utility groups: enthusiasts, who had a high probability of agreement with all utility items (23%); health conscious, who perceived utility in medically related areas (60%) or skeptics, who had a low probability of agreement with utility items (17%). Trust significantly predicted latent class.
  
  
  CONCLUSIONS
  Understanding differences in perceived utility of WGS may inform strategies for uptake of this technology.
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Lupo
authors.affiliation: Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Jill O
authors.initials: JO
authors.lastname: Robinson
authors.affiliation: Division of Health Promotion & Behavioral Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Diamond
authors.affiliation: Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Leila
authors.initials: L
authors.lastname: Jamal
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Heather E
authors.initials: HE
authors.lastname: Danysh
authors.affiliation: Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Blumenthal-Barby
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA; Division of General Medicine & Primary Care, Department of Medicine, Brigham & Women's Hospital, Boston, MA 20115, USA.
authors.forename: Lisa Soleymani
authors.initials: LS
authors.lastname: Lehmann
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA; Division of General Medicine & Primary Care, Department of Medicine, Brigham & Women's Hospital, Boston, MA 20115, USA; Section of General Internal Medicine, VA Boston Healthcare System, Boston, MA 02130, USA.
authors.forename: Jason L
authors.initials: JL
authors.lastname: Vassy
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA.
authors.forename: Kurt D
authors.initials: KD
authors.lastname: Christensen
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Green
authors.affiliation: Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: McGuire
keywords: clinical utility; patient perspectives; perceived utility; personal utility; whole-genome sequencing