title: Review: Ras GTPases and myosin: Qualitative conservation and quantitative diversification in signal and energy transduction.
abstract: Most GTPases and many ATPases belong to the P-loop class of proteins with significant structural and mechanistic similarities. Here we compare and contrast the basic properties of the Ras family GTPases and myosin, and conclude that there are fundamental similarities but also distinct differences related to their specific roles. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 422-430, 2016.
authors.affiliation: Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany.
authors.forename: Matthias P
authors.initials: MP
authors.lastname: Mueller
authors.affiliation: Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany.
authors.forename: Roger S
authors.initials: RS
authors.lastname: Goody
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009218:Myosins / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary; D013329:Structure-Activity Relationship; D018631:ras Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D009218:Myosins; D018631:ras Proteins
keywords: P-loop; Ras GTPases; myosin; switch I; switch II