title: The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs.
abstract: Critical polytrauma patients present a series of pathophysiological disturbances, biochemical and molecular dysfunction, which comprise to be the major cause of intensive care unit admission. In regard to molecular damage, there exists a series of factors, which all together contribute to the aggravation of the clinical status leading to increased mortality rate in these patients. One of the most important biochemical factors involved is the nuclear transcription factor B (NF-κB). Impaired NF-κB functioning is reflected on the clinical status of the patient through increased production of pro-inflammatory molecule, leading to multiple organ dysfunction syndrome. In addition to this, through microRNAs interactions, various pathophysiological as well as biochemical disturbances are produced, which altogether further reduce the patient's survival rate. In this paper, we would like to present the modifications seen in the expression of NF-κB in critically polytraumatized patients with sepsis. In additions to this, we would like to discuss the correlation between the microRNAs and its further implications in clinical status of these patients.
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Iosif Bulbuca Nr.10, 300736, Timisoara, Romania.|Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Papurica
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Iosif Bulbuca Nr.10, 300736, Timisoara, Romania. alexandru.rogobete@umft.ro.|Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. alexandru.rogobete@umft.ro.
authors.forename: Alexandru Florin
authors.identifier: http://orcid.org/0000-0003-1286-4431
authors.initials: AF
authors.lastname: Rogobete
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Iosif Bulbuca Nr.10, 300736, Timisoara, Romania.|Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Dorel
authors.initials: D
authors.lastname: Sandesc
authors.affiliation: Clinic of Anesthesia and Intensive Care "Casa Austria", Emergency County Hospital "Pius Brinzeu", Timisoara, Romania.
authors.forename: Carmen Alina
authors.initials: CA
authors.lastname: Cradigati
authors.affiliation: Clinic of Anesthesia and Intensive Care "Casa Austria", Emergency County Hospital "Pius Brinzeu", Timisoara, Romania.
authors.forename: Mirela
authors.initials: M
authors.lastname: Sarandan
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Dan Ciprian
authors.initials: DC
authors.lastname: Crisan
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Florin George
authors.initials: FG
authors.lastname: Horhat
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Boruga
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Raluca
authors.initials: R
authors.lastname: Dumache
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Kundnani Rajpal
authors.initials: KR
authors.lastname: Nilima
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Razvan
authors.initials: R
authors.lastname: Nitu
authors.affiliation: Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Horia
authors.initials: H
authors.lastname: Stanca
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Iosif Bulbuca Nr.10, 300736, Timisoara, Romania.|Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Ovidiu Horea
authors.initials: OH
authors.lastname: Bedreag
mesh_terms: D016638:Critical Illness; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009104:Multiple Trauma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D018805:Sepsis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D016328:NF-kappa B
keywords: Nuclear transcription factor kappa B (NF-κB); Polytrauma patients; Sepsis; microRNAs