title: Resveratrol Inhibition of Cellular Respiration: New Paradigm for an Old Mechanism.
abstract: Resveratrol (3,4',5-trihydroxy-trans-stilbene, RSV) has emerged as an important molecule in the biomedical area. This is due to its antioxidant and health benefits exerted in mammals. Nonetheless, early studies have also demonstrated its toxic properties toward plant-pathogenic fungi of this phytochemical. Both effects appear to be opposed and caused by different molecular mechanisms. However, the inhibition of cellular respiration is a hypothesis that might explain both toxic and beneficial properties of resveratrol, since this phytochemical: (1) decreases the production of energy of plant-pathogenic organisms, which prevents their proliferation; (2) increases adenosine monophosphate/adenosine diphosphate (AMP/ADP) ratio that can lead to AMP protein kinase (AMPK) activation, which is related to its health effects, and (3) increases the reactive oxygen species generation by the inhibition of electron transport. This pro-oxidant effect induces expression of antioxidant enzymes as a mechanism to counteract oxidative stress. In this review, evidence is discussed that supports the hypothesis that cellular respiration is the main target of resveratrol.
authors.affiliation: Laboratorio de Biotecnología Microbiana, Ingeniería Bioquímica, Instituto Tecnológico Superior de Ciudad Hidalgo, Ciudad Hidalgo 61100, Mexico. lmadrigal@itsch.edu.mx.|PROPAC, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas S/N, Queretaro 76010, Mexico. lmadrigal@itsch.edu.mx.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Madrigal-Perez
authors.affiliation: PROPAC, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas S/N, Queretaro 76010, Mexico. ramosgomezm@yahoo.com.
authors.forename: Minerva
authors.initials: M
authors.lastname: Ramos-Gomez
mesh_terms: D000818:Animals; D000975:Antioxidants; D019069:Cell Respiration / Q000187:drug effects*; D006801:Humans; D018384:Oxidative Stress; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol
keywords: antioxidant; cellular respiration; energy homeostasis; mitochondrial dysfunction; molecular mechanism; resveratrol