title: An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase.
abstract: In a recent study we have shown that several indole-5,6-dicarbonitrile derivatives are potent inhibitors of human monoamine oxidase (MAO) A and B. To expand on these results and to further determine structure-activity relationships (SARs) for MAO inhibition by this chemical class, the present study investigates the MAO inhibition properties of additional indole-5,6-dicarbonitriles and related indole-5,6-dicarboxylic acid and pyrrolo[3,4-f]indole-5,7-dione derivatives. Among the active compounds two pyrrolo[3,4-f]indole-5,7-dione derivatives inhibited MAO-A (4 g) and MAO-B (4d) with IC50 values of 0.250 and 0.581 μM, respectively. In general indole-5,6-dicarbonitriles, however, exhibit higher MAO inhibition potencies while indole-5,6-dicarboxylic acids are weak MAO inhibitors. Active MAO inhibitors such as 4 g and 4d may be used as leads for the development of drugs for the treatment of disease states such as Parkinson's disease and depression. MAO inhibitors are also under investigation as potential agents for the treatment of prostate cancer, certain types of cardiomyopathies and Alzheimer's disease.
authors.affiliation: Yaroslavl State Technical University, 150023 Yaroslavl, Russian Federation.
authors.forename: Zhanna V
authors.initials: ZV
authors.lastname: Chirkova
authors.affiliation: Yaroslavl State Technical University, 150023 Yaroslavl, Russian Federation.
authors.forename: Mariya V
authors.initials: MV
authors.lastname: Kabanova
authors.affiliation: Yaroslavl State Technical University, 150023 Yaroslavl, Russian Federation.
authors.forename: Sergey I
authors.initials: SI
authors.lastname: Filimonov
authors.affiliation: Yaroslavl State Technical University, 150023 Yaroslavl, Russian Federation.
authors.forename: Igor G
authors.initials: IG
authors.lastname: Abramov
authors.affiliation: Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa.
authors.forename: Anél
authors.initials: A
authors.lastname: Petzer
authors.affiliation: Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa.
authors.forename: Jacobus P
authors.initials: JP
authors.lastname: Petzer
authors.affiliation: A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., 119991 Moscow, Russian Federation.
authors.forename: Kyrill Yu
authors.initials: KY
authors.lastname: Suponitsky
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D008996:Monoamine Oxidase Inhibitors
keywords: Dicarbonitrile; Indole; Inhibition; MAO; Monoamine oxidase; Selective