title: Lamin in inflammation and aging.
abstract: Aging is characterized by a progressive loss of tissue function and an increased susceptibility to injury and disease. Many age-associated pathologies manifest an inflammatory component, and this has led to the speculation that aging is at least in part caused by some form of inflammation. However, whether or not inflammation is truly a cause of aging, or is a consequence of the aging process is unknown. Recent work using Drosophila has uncovered a mechanism where the progressive loss of lamin-B in the fat body upon aging triggers systemic inflammation. This inflammatory response perturbs the local immune response of the neighboring gut tissue and leads to hyperplasia. Here, we will discuss the literature connecting lamins to aging and inflammation.
authors.affiliation: Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, United States.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Tran
authors.affiliation: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, PR China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, United States.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, United States. Electronic address: zheng@ciwemb.edu.
authors.forename: Yixian
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000375:Aging / Q000276:immunology / Q000473:pathology*; D000818:Animals; D004330:Drosophila; D005216:Fat Body / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D034921:Lamin Type B / Q000378:metabolism*
chemical_list: D034921:Lamin Type B