title: James L. German, a pioneer in early human genetic research turned 90.
abstract: In the early 1960s, J. German established the non-synchronous human DNA replication pattern in metaphases of cultured lymphocytes and fibroblasts. This could be used to distinguish several chromosomes of similar morphology. From 1965 on over the next 30 years, he and his coworkers systematically studied Bloom's syndrome in depth, cumulating in the identification in 1995 of the BLM gene as encoding a DNA helicase. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Institut für Humangenetik, Universitätsklinikum Essen, Essen, Germany.
authors.forename: Eberhard
authors.initials: E
authors.lastname: Passarge
mesh_terms: D001816:Bloom Syndrome / Q000175:diagnosis / Q000235:genetics / Q000266:history; D004261:DNA Replication; D005197:Famous Persons; D036281:Genetic Research / Q000266:history; D005826:Genetics, Medical / Q000266:history; D049673:History, 20th Century; D006801:Humans; D053484:RecQ Helicases / Q000235:genetics; D014481:United States
chemical_list: C097151:Bloom syndrome protein; D053484:RecQ Helicases
keywords: Bloom's syndrome; growth retardation; human chromosomes