title: Dimethyloxalylglycine may be enhance the capacity of neural-like cells in treatment of Alzheimer disease.
abstract: Although using differentiated stem cells is the best proposed option for the treatment of Alzheimer disease (AD), an efficient differentiation and cell therapy require enhanced cell survival and homing and decreased apoptosis. It seems that hypoxia preconditioning via Dimethyloxalylglycine (DMOG) may increase the capacity of MSC to induce neural like stem cells (NSCs). Furthermore, it can likely improve the viability of NSCs when transplanted into the brain of AD rats.
authors.affiliation: Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Ghasemi Moravej
authors.affiliation: Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mehrangiz
authors.initials: M
authors.lastname: Vahabian
authors.affiliation: Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.|Cell Therapy Division of Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Soleimani Asl
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D015687:Cell Hypoxia / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D058953:Neural Stem Cells / Q000187:drug effects* / Q000378:metabolism / Q000637:transplantation*; D051381:Rats; D019172:Transplantation Conditioning / Q000379:methods
chemical_list: D000600:Amino Acids, Dicarboxylic; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C040947:oxalylglycine
keywords: Alzheimer disease; DMOG; cell therapy