title: Status of research and development of vaccines for chikungunya.
abstract: Chikungunya virus (CHIKV) is an arthritogenic alphavirus that during the last decade has significantly expanded its geographical range and caused large outbreaks of human disease around the world. Although mortality rates associated with CHIKV outbreaks are low, acute and chronic illnesses caused by CHIKV represent a significant burden of disease largely affecting low and middle income countries. This report summarizes the current status of vaccine development for CHIKV.
authors.affiliation: Experimental Pathology Graduate Program, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Smalley
authors.affiliation: Human Pathophysiology and Translational Medicine Graduate Program, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Jesse H
authors.initials: JH
authors.lastname: Erasmus
authors.affiliation: Human Pathophysiology and Translational Medicine Graduate Program, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Chesson
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA; World Health Organization Collaborating Center for Vaccine Research, Evaluation and Training on Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: dwbeasle@utmb.edu.
authors.forename: David W C
authors.initials: DWC
authors.lastname: Beasley
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D065632:Chikungunya Fever / Q000517:prevention & control*; D002646:Chikungunya virus; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D014765:Viral Vaccines
keywords: Alphavirus; Chikungunya; Emerging disease; Polyarthralgia; Vaccine