title: Interleukin-22 promotes papillary thyroid cancer cell migration and invasion through microRNA-595/Sox17 axis.
abstract: Interleukin-22 (IL-22) is an inflammatory cytokine mainly produced by activated Th17 and Th22 cells. The data presented here demonstrate that IL-22 induced the migration and invasion of papillary thyroid cancer (PTC) cells. MicroRNA expression analysis and functional studies indicated that IL-22-mediated migration and invasion is positively regulated by miR-595. Further mechanistic studies revealed that sex-determining region Y-box 17 (Sox17) is directly targeted by miR-595. We then demonstrated that IL-22 regulated migration and invasion of PTC cells via inhibiting Sox17 expression. Interestingly, in PTC cell lines and PTC tissues, expression of IL-22 and miR-595 was upregulated and Sox17 downregulated compared with normal thyroid, and their expression levels were closely correlated. Taken together, this present study suggests that IL-22 stimulation enhances the migration and invasion of PTC cells by regulating miR-595 and its target Sox17.
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Zhidan
authors.initials: Z
authors.lastname: Mei
authors.affiliation: Animal Biosafety Level III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, 430071, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Youhua
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Kejia
authors.initials: K
authors.lastname: Jie
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Daqing
authors.initials: D
authors.lastname: Fan
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Xiguo
authors.initials: X
authors.lastname: Liu
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Jiang
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China.
authors.forename: Qike
authors.initials: Q
authors.lastname: Jia
authors.affiliation: The department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 430079, China. liwei201009@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D006801:Humans; D007378:Interleukins / Q000494:pharmacology*; D035683:MicroRNAs / Q000502:physiology*; D009361:Neoplasm Invasiveness; D055760:SOXF Transcription Factors / Q000235:genetics / Q000502:physiology*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology*; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D035683:MicroRNAs; D055760:SOXF Transcription Factors; D000097043:Interleukin-22; C109188:SOX17 protein, human; C000609695:microRNA595 microRNA, human
keywords: Interleukin-22; Invasion; Migration; Papillary thyroid cancer; Sox17; miR-595