title: An Unusual Type of Kidney Stone.
abstract: A very rare case of acetylsulfapyridine nephrolithiasis is presented in a 54-year-old female patient who had been prescribed sulfasalazine (6 x 500 mg/day) because of psoriatic arthritis for the last 9 years. The patient's renal function was only slightly impaired. Reflectance infrared spectroscopy and gas chromatography-mass spectrometry allowed the identification of the chemical nature of the stone. As acetylsulfapyridine is a metabolite of sulfasalazine, administration of the latter drug was the cause of the nephrolithiasis.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: De Koninck
authors.forename: Luitzen-Albert
authors.initials: LA
authors.lastname: Groen
authors.forename: Heleen
authors.initials: H
authors.lastname: Maes
authors.forename: Alain Gaston
authors.initials: AG
authors.lastname: Verstraete
authors.forename: Veronique
authors.initials: V
authors.lastname: Stove
authors.forename: Joris Richard
authors.initials: JR
authors.lastname: Delanghe
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000097:blood; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D001711:Biotransformation; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007669:Kidney Calculi / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D013055:Spectrophotometry, Infrared; D013427:Sulfapyridine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D012460:Sulfasalazine / Q000009:adverse effects* / Q000097:blood
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C005377:N-acetylsulfapyridine; D012460:Sulfasalazine; D013427:Sulfapyridine