title: Therapeutic Potential of Human Chorionic Gonadotropin Against Painful Bladder Syndrome/Interstitial Cystitis.
abstract: Painful bladder syndrome/interstitial cystitis is a debilitating chronic bladder disease that primarily affects women. The disease is due to a damage of urothelial cell lining. As a result, potassium particles and other toxic substances in urine can leak into bladder mucosa, causing the symptoms of lower abdominal/pelvic discomfort, pain, increased urination frequency, urgency, nocturia, and so on, all of which can substantially reduce the quality of daily life. There are multiple symptom reliving therapies. Among them, only pentosan polysulfate sodium, sold under the brand name of Elmiron, has been approved for oral use by US Food and Drug Administration. It provides the relief after several months of use. Based on the scientific leads presented in this article, we propose that human chorionic gonadotropin has a therapeutic potential that is worth investigating for the treatment of this disease.
authors.affiliation: Departments of Cellular Biology and Pharmacology, Molecular and Human Genetics and Obstetrics and Gynecology, Reproduction and Development Program, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA crao@fiu.edu.
authors.forename: C V
authors.initials: CV
authors.lastname: Rao
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D018856:Cystitis, Interstitial / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use; D001743:Urinary Bladder / Q000503:physiopathology
chemical_list: D006063:Chorionic Gonadotropin; D010426:Pentosan Sulfuric Polyester
keywords: gonadotropins; hCG/LH receptors; interstitial cystitis; painful bladder syndrome; urinary bladder; urothelial cells