title: Association Between Thrombophilic Gene Mutations and the Risk of Vascular Access Thrombosis in Hemodialysis Patients.
abstract: The cause of thrombosis in hemodialysis vascular access is considered to be of a multifactorial nature, including stenosis of the venous or arterial connection. Therefore, identification of relevant thrombotic risk factors could lead to an improved antithrombotic therapy. This case control study was performed to evaluate the relationship between Factor V (G1691A and A4070G) and Factor II polymorphisms and vascular access thrombosis in hemodialysis patients. One hundred and twenty-one patients undergoing dialysis were selected as subjects. This sample was divided into two groups; a case group of 60 patients who had sustained one or more thrombotic events that resulted in vascular access failure and a control group of 61 patients, who never had a thrombotic occlusion of a functioning permanent dialysis access. Our data demonstrated a significantly increased risk of vascular access thrombosis in carriers of the mutant FV (G1691A and A4070G) polymorphisms (P < 0.05).Further studies on a large-scale population and other genetic variants will be needed to find candidate genes for vascular access thrombosis in hemodialysis patients.
authors.affiliation: Laboratory of Molecular Biology, Department of Hematology.
authors.forename: Najiba
authors.initials: N
authors.lastname: Fekih-Mrissa
authors.affiliation: Laboratory of Molecular Biology, Department of Hematology.
authors.forename: Aycha
authors.initials: A
authors.lastname: Sayeh
authors.affiliation: Department of Hemodialysis, Military Hospital of Tunisia, Tunis, Tunisia.
authors.forename: Anis
authors.initials: A
authors.lastname: Baffoun
authors.affiliation: Department of Hemodialysis, Military Hospital of Tunisia, Tunis, Tunisia.
authors.forename: Maher
authors.initials: M
authors.lastname: Beji
authors.affiliation: Laboratory of Molecular Biology, Department of Hematology.
authors.forename: Meriem
authors.initials: M
authors.lastname: Mrad
authors.affiliation: Department of Hemodialysis, Military Hospital of Tunisia, Tunis, Tunisia.
authors.forename: Jalel
authors.initials: J
authors.lastname: Hmida
authors.affiliation: Laboratory of Molecular Biology, Department of Hematology.
authors.forename: Brahim
authors.initials: B
authors.lastname: Nsiri
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*; D006435:Renal Dialysis; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology* / Q000235:genetics; D062666:Vascular Access Devices / Q000009:adverse effects
chemical_list: D005165:Factor V; D011516:Prothrombin
keywords: Factor II; Factor V Leiden; HR2 haplotype; Hemodialysis; Vascular access thrombosis