title: An epidemic of coxsackievirus B3 infection in infants and children in Jiangsu Province, China: a prospective cohort study.
abstract: To investigate the epidemiological data on coxsackievirus B3 (CVB3) infection and its incidence in infants and children, a prospective cohort study was carried out from 2012 to 2014 in Jiangsu Province, China. According to the results of seropositive rates and NTAb titers of CVB3, an epidemic of CVB3 infection was found, and a dynamic change in CVB3 neutralizing antibody was also observed. One case was recorded with CVB3-associated hand, foot and mouth disease (HFMD), and the isolates belonged to the CVB3 D2 subtype. Our data help us to better understand the epidemic characteristics of CVB3 infection in infants and children.
authors.affiliation: National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Beijing, 100050, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Gao
authors.affiliation: National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Beijing, 100050, People's Republic of China.
authors.forename: Lian-Lian
authors.initials: LL
authors.lastname: Bian
authors.affiliation: National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Beijing, 100050, People's Republic of China.
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Mao
authors.affiliation: National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Beijing, 100050, People's Republic of China.
authors.forename: Pan
authors.initials: P
authors.lastname: Chen
authors.affiliation: National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Beijing, 100050, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yao
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China.
authors.forename: Jing-Xin
authors.initials: JX
authors.lastname: Li
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China.
authors.forename: Feng-Cai
authors.initials: FC
authors.lastname: Zhu
authors.affiliation: National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Beijing, 100050, People's Republic of China. lzhenglun@126.com.
authors.forename: Zheng-Lun
authors.initials: ZL
authors.lastname: Liang
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003384:Coxsackievirus Infections / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D029822:Enterovirus B, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: Coxsackievirus B3; Hand, foot and mouth disease; Prospective cohort study