title: Brain parcellation choice affects disease-related topology differences increasingly from global to local network levels.
abstract: Network-based analyses of deviant brain function have become extremely popular in psychiatric neuroimaging. Underpinning brain network analyses is the selection of appropriate regions of interest (ROIs). Although ROI selection is fundamental in network analysis, its impact on detecting disease effects remains unclear. We investigated the impact of parcellation choice when comparing results from different studies. We investigated the effects of anatomical (AAL) and literature-based (Dosenbach) parcellation schemes on comparability of group differences in 35 female patients with anorexia nervosa and 35 age- and sex-matched healthy controls. Global and local network properties, including network-based statistics (NBS), were assessed on resting state functional magnetic resonance imaging data obtained at 3T. Parcellation schemes were comparably consistent on global network properties, while NBS and local metrics differed in location, but not metric type. Location of local metric alterations varied for AAL (parietal and cingulate cortices) versus Dosenbach (insula, thalamus) parcellation approaches. However, consistency was observed for the occipital cortex. Patient-specific global network properties can be robustly observed using different parcellation schemes, while graph metrics characterizing impairments of individual nodes vary considerably. Therefore, the impact of parcellation choice on specific group differences varies depending on the level of network organization.
authors.affiliation: Leibniz Institute for Neurobiology, Magdeburg, Saxony-Anhalt, Germany; Clinical Affective Neuroimaging Laboratory, Magdeburg, Saxony-Anhalt, Germany.
authors.forename: Anton
authors.initials: A
authors.lastname: Lord
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Research and Treatment Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany; MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
authors.affiliation: Leibniz Institute for Neurobiology, Magdeburg, Saxony-Anhalt, Germany; Clinical Affective Neuroimaging Laboratory, Magdeburg, Saxony-Anhalt, Germany.
authors.forename: Viola
authors.initials: V
authors.lastname: Borchardt
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Research and Treatment Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany; Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Geisler
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Research and Treatment Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany; Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Seidel
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Research and Treatment Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany; Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Huber
authors.affiliation: Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany; Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Murr
authors.affiliation: Leibniz Institute for Neurobiology, Magdeburg, Saxony-Anhalt, Germany; Clinical Affective Neuroimaging Laboratory, Magdeburg, Saxony-Anhalt, Germany; Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Saxony-Anhalt, Germany; Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany. Electronic address: martin.walter@med.ovgu.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Walter
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D002648:Child; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D013788:Thalamus / Q000000981:diagnostic imaging / Q000503:physiopathology; D055815:Young Adult
keywords: Anorexia nervosa; Graph metrics; Resting state; fMRI