title: CLINICAL INFECTION OF CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 4.
abstract: Elephant endotheliotropic herpesvirus (EEHV) can cause lethal hemorrhagic disease in juvenile Asian elephants. A number of EEHV types and subtypes exist, where most deaths have been caused by EEHV1A and EEHV1B. EEHV4 has been attributed to two deaths, but as both diagnoses were made postmortem, EEHV4 disease has not yet been observed and recorded clinically. In this brief communication, two cases of EEHV4 infection in juvenile elephants at the Houston Zoo are described, where both cases were resolved following intensive treatment and administration of famciclovir. A quantitative real-time polymerase chain reaction detected EEHV4 viremia that correlated with clinical signs. High levels of EEHV4 shedding from trunk wash secretions of the first viremic elephant correlated with subsequent infection of the second elephant with EEHV4. It is hoped that the observations made in these cases--and the successful treatment regimen used--will help other institutions identify and treat EEHV4 infection in the future.
authors.forename: Angela
authors.initials: A
authors.lastname: Fuery
authors.forename: Geoffrey R
authors.initials: GR
authors.lastname: Browning
authors.forename: Jie
authors.initials: J
authors.lastname: Tan
authors.forename: Simon
authors.initials: S
authors.lastname: Long
authors.forename: Gary S
authors.initials: GS
authors.lastname: Hayward
authors.forename: Sherry K
authors.initials: SK
authors.lastname: Cox
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Flanagan
authors.forename: Maryanne E
authors.initials: ME
authors.lastname: Tocidlowski
authors.forename: Lauren L
authors.initials: LL
authors.lastname: Howard
authors.forename: Paul D
authors.initials: PD
authors.lastname: Ling
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000836:Animals, Zoo; D000998:Antiviral Agents / Q000627:therapeutic use; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D004606:Elephants; D000077595:Famciclovir; D005260:Female; D006564:Herpesviridae / Q000145:classification* / Q000235:genetics; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D008297:Male; D013781:Texas / Q000453:epidemiology; D014766:Viremia
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D015075:2-Aminopurine; D000077595:Famciclovir
keywords: Asian elephant; EEHV4; Elephas maximus; Famciclovir; qPCR