title: Central Giant Cell Granuloma of the Mandible Requiring Multiple Treatment Modalities: A Case Report.
abstract: Central giant cell granuloma (CGCG) is a relatively rare non-neoplastic, intraosseous lesion that exhibits a wide spectrum of clinical behavior, and its management can be particularly challenging even for experienced clinicians. The etiopathogenesis of this disease process remains unclear, although factors such as trauma, inflammatory foci, and a genetic predisposition have been implicated. Although multiple treatment modalities have been used with varying degrees of success, there is no accepted algorithm for therapeutic intervention and little is known about the reasons for success or failure of a given treatment. This article reviews the epidemiology, presentation, classification, and currently used therapies for CGCG while describing the clinical course and successful therapeutic outcome of a young female patient with an aggressive CGCG of the mandible.
authors.affiliation: Resident, Wright State University Plastic Surgery Residency Program, Dayton, OH. Electronic address: david.jerkins@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Jerkins
authors.affiliation: Resident, Wright State University Plastic Surgery Residency Program, Dayton, OH.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Malotky
authors.affiliation: Private Practitioner, Clinical Faculty, Wright State University Plastic Surgery Residency Program, Dayton, OH.
authors.forename: Reza
authors.initials: R
authors.lastname: Miremadi
authors.affiliation: Faculty Physician, Pediatric Hematology and Oncology, Dayton Children's Hospital, Dayton, OH.
authors.forename: Mukund
authors.initials: M
authors.lastname: Dole
mesh_terms: D001706:Biopsy; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006101:Granuloma, Giant Cell / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D014057:Tomography, X-Ray Computed