title: A comprehensive computational human lung model incorporating inter-acinar dependencies: Application to spontaneous breathing and mechanical ventilation.
abstract: In this article, we propose a comprehensive computational model of the entire respiratory system, which allows simulating patient-specific lungs under different ventilation scenarios and provides a deeper insight into local straining and stressing of pulmonary acini. We include novel 0D inter-acinar linker elements to respect the interplay between neighboring alveoli, an essential feature especially in heterogeneously distended lungs. The model is applicable to healthy and diseased patient-specific lung geometries. Presented computations in this work are based on a patient-specific lung geometry obtained from computed tomography data and composed of 60,143 conducting airways, 30,072 acini, and 140,135 inter-acinar linkers. The conducting airways start at the trachea and end before the respiratory bronchioles. The acini are connected to the conducting airways via terminal airways and to each other via inter-acinar linkers forming a fully coupled anatomically based respiratory model. Presented numerical examples include simulation of breathing during a spirometry-like test, measurement of a quasi-static pressure-volume curve using a supersyringe maneuver, and volume-controlled mechanical ventilation. The simulations show that our model incorporating inter-acinar dependencies successfully reproduces physiological results in healthy and diseased states. Moreover, within these scenarios, a deeper insight into local pressure, volume, and flow rate distribution in the human lung is investigated and discussed. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Institute for Computational Mechanics, Technische Universität München, D-85747 Garching, Germany.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Roth
authors.affiliation: Institute for Computational Mechanics, Technische Universität München, D-85747 Garching, Germany.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ismail
authors.affiliation: Institute for Computational Mechanics, Technische Universität München, D-85747 Garching, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Yoshihara
authors.affiliation: Institute for Computational Mechanics, Technische Universität München, D-85747 Garching, Germany.
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Wall
mesh_terms: D006801:Humans; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008954:Models, Biological; D011650:Pulmonary Alveoli / Q000502:physiology; D012119:Respiration; D012121:Respiration, Artificial; D015656:Respiratory Mechanics; D014057:Tomography, X-Ray Computed
keywords: acinar model; alveolar overstraining; lung interdependence; reduced-dimensional modeling; respiratory mechanics