title: Alcohol-triggered signs of migraine: An animal model.
abstract: We describe an animal model where characteristics of migraine can be triggered by alcohol administration. In rats chronically implanted with a cannula overlying the transverse sinus, we applied potassium chloride (KCl) (or saline) to the meninges to sensitize trigeminovascular afferents. We assessed effects of repeated KCl application on animal behavior using conditioned place avoidance paradigm. In KCl-treated rats we discovered that alcohol injections (0.2 mg/kg), but not saline, resulted in the development of extracephalic allodynia and signs of ongoing pain.
authors.affiliation: a Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland School of Dentistry , Baltimore , MD , USA ;
authors.forename: Yaqoub
authors.initials: Y
authors.lastname: Alabwah
authors.affiliation: a Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland School of Dentistry , Baltimore , MD , USA ;
authors.forename: Yadong
authors.initials: Y
authors.lastname: Ji
authors.affiliation: b Department of Neural and Pain Sciences , University of Maryland School of Dentistry , Baltimore , MD , USA ;|c Program in Neuroscience , University of Maryland , Baltimore , MD , USA ;
authors.forename: David A
authors.initials: DA
authors.lastname: Seminowicz
authors.affiliation: b Department of Neural and Pain Sciences , University of Maryland School of Dentistry , Baltimore , MD , USA ;|d Department of Psychology , University of Maryland, Baltimore County , Baltimore , MD , USA ;|e Department of Anatomy and Neurobiology , University of Maryland School of Medicine , Baltimore , MD , USA.
authors.forename: Raimi L
authors.initials: RL
authors.lastname: Quiton
authors.affiliation: a Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland School of Dentistry , Baltimore , MD , USA ;|c Program in Neuroscience , University of Maryland , Baltimore , MD , USA ;|e Department of Anatomy and Neurobiology , University of Maryland School of Medicine , Baltimore , MD , USA.
authors.forename: Radi
authors.initials: R
authors.lastname: Masri
mesh_terms: D000438:Alcohols / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D006930:Hyperalgesia / Q000209:etiology; D008297:Male; D008881:Migraine Disorders / Q000139:chemically induced*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D011189:Potassium Chloride / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000438:Alcohols; D011189:Potassium Chloride
keywords: Migraine; headache; trigeminal