title: Interleukin 18 -607 A/C Gene Polymorphism is Associated With Susceptibility to IgA Nephropathy in a Chinese Han Population.
abstract: The association between a single-nucleotide polymorphism (SNP; -607A/C) in the promoter region of the IL-18 gene with IL-18 promoter transcription activity and the level of IL-18 protein production has been observed repeatedly. However, the association between the IL-18-607A/C (rs1946518) promoter polymorphism and IgA nephropathy (IgAN) in a Chinese Han population is still unclear. A total of 166 patients with renal biopsy-proven IgAN and 198 healthy controls were recruited for this study. The SNP was genotyped by the polymerase chain reaction and the high-resolution melting method. Clinical characteristics and pathology grading of patients with IgAN were recorded at the time of the kidney biopsy. There was a significant difference in the distribution between the AA genotype and the AC/CC genotype [P=0.007, OR (95% CI)=1.885 (1.183-3.003)]. However, no significant differences were observed between the rs1946518 SNP and quantitative traits (all P>0.05) or different pathology grades (Lee's grading system and tubular atrophy/interstitial fibrosis according to the Oxford classification) (P=0.769 and P=0.7) of the patients. We first demonstrated that the AA genotype of the IL-18-607A/C was associated with an increased susceptibility to IgAN in this population.
authors.affiliation: Departments of *Laboratory Medicine, Division of Clinical Immunology †Nephrology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Weihua
authors.initials: W
authors.lastname: Feng
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Yunying
authors.initials: Y
authors.lastname: Shi
authors.forename: Bei
authors.initials: B
authors.lastname: Cai
authors.forename: Yun
authors.initials: Y
authors.lastname: Liao
authors.forename: Junlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhuochun
authors.initials: Z
authors.lastname: Huang
authors.forename: Lanlan
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C000589760:IL18 protein, human; D020382:Interleukin-18