title: Dental Applications of Natural-Origin Polymers in Hard and Soft Tissue Engineering.
abstract: Clinical advances in the treatment of dentoalveolar defects continue to evolve with the introduction of new innovations in regenerative medicine and tissue bioengineering. Recent developments in tissue engineering are aimed at safely and effectively regenerating a damaged or necrotic area by replenishing its cells and increasing surrounding gene expression. Various techniques have successfully given rise to porous scaffolds being used by clinicians to treat the defect and initiate the repair process. Tissue reconstruction using bioengineered scaffolds is advantageous over traditional autografting, since it prevents the instigation of pain and donor site morbidity while ultimately creating both the environment and machinery needed to induce cell proliferation, migration, and reattachment within the affected area. This review article aims to describe and review the available literature regarding the regenerative capacity of natural polymers used for the treatment of dentoalveolar defects. The repair mechanisms, advantages of protein and polysaccharide derivatives, and the potential of stem cell therapy are discussed.
authors.affiliation: University of Pennsylvania School of Dental Medicine, Philadelphia, PA.|Marquette University School of Dentistry, Milwaukee, WI.
authors.forename: Hossein E
authors.initials: HE
authors.lastname: Jazayeri
authors.affiliation: Marquette University School of Dentistry, Milwaukee, WI.
authors.forename: Mina D
authors.initials: MD
authors.lastname: Fahmy
authors.affiliation: BCAST, Institute of Materials and Manufacturing, Brunel University London, Uxbridge, London, UK.|Brunel Institute for Bioengineering, Brunel University London, Uxbridge, London, UK.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Razavi
authors.affiliation: University of Pennsylvania School of Dental Medicine, Philadelphia, PA.
authors.forename: Brett E
authors.initials: BE
authors.lastname: Stein
authors.affiliation: Marquette University School of Dentistry, Milwaukee, WI.
authors.forename: Aatif
authors.initials: A
authors.lastname: Nowman
authors.affiliation: Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland School of Dentistry, Baltimore, MD.
authors.forename: Radi M
authors.initials: RM
authors.lastname: Masri
authors.affiliation: Marquette University School of Dentistry, Milwaukee, WI.|Department of Engineering Science, University of Oxford, Oxford, UK.
authors.forename: Lobat
authors.initials: L
authors.lastname: Tayebi
mesh_terms: D003813:Dentistry / Q000639:trends*; D006244:Hardness; D006801:Humans; D011108:Polymers; D044968:Regenerative Medicine; D023822:Tissue Engineering; D014070:Tooth
chemical_list: D011108:Polymers
keywords: Scaffolds; bioengineering; craniofacial; prosthetic; regeneration