title: Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls.
abstract: The relationship between polychlorinated biphenyl (PCB) burden and several indicators of immune function was investigated as part of the HELPcB (Health Effects in High-Level Exposure to PCB) program, offering bio-monitoring to workers, relatives, and neighbors exposed to PCBs by a German transformers and capacitors recycling company. The present retrospective observational study evaluates the correlation of plasma levels of total PCBs, five indicator congeners (28, 101, 138, 153, 180), and seven dioxin-like congeners (105, 114, 118, 156, 157, 167, 189) with several parameters of immune function. The cross-sectional study was performed immediately after the end of exposure (258 subjects), and one (218 subjects), and two (177 subjects) years later. At the first time point, measurements showed significant positive correlation between congeners with low to medium chlorination and the relative proportion of CD19 positive B-cells among lymphocytes, as well as a negative correlation of PCB114 with serum IgM, and of PCB 28 with suppressor T-cell and NK-cell numbers. Congeners with a high degree of chlorination, in particular PCB157 and 189, were positively associated with expression of the activation marker CD25 on T-cells in the cohort of the second time point. No associations between PCB levels and IFN-y production by T-cells and killing by NK-cells were found. In conclusion, there were several effects on the cellular composition of adaptive immunity, affecting both T- and B-cells. However, the values were not generally outside the reference ranges for healthy adult individuals and did not indicate overt functional immunodeficiency, even in subjects with the uppermost PCB burden.
authors.affiliation: Medical Faculty, Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstrasse 30, Aachen D-52074, Germany. Haase@TU-Berlin.de.|Department of Food Chemistry and Toxicology, Berlin Institute of Technology, Gustav-Meyer-Allee 25, Berlin D-13355, Germany. Haase@TU-Berlin.de.
authors.forename: Hajo
authors.initials: H
authors.lastname: Haase
authors.affiliation: Department of Anesthesiology, University Hospital Aachen, Pauwelsstrasse 30, Aachen D-52074, Germany. afahlenkamp@ukaachen.de.
authors.forename: Astrid
authors.initials: A
authors.lastname: Fahlenkamp
authors.affiliation: Department of Occupational and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen D-52074, Germany. tschettgen@ukaachen.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schettgen
authors.affiliation: Department of Occupational and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen D-52074, Germany. anesser@ukaachen.de.
authors.forename: Andre
authors.initials: A
authors.lastname: Esser
authors.affiliation: Department of Occupational and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen D-52074, Germany. mgube@ukaachen.de.
authors.forename: Monika
authors.initials: M
authors.lastname: Gube
authors.affiliation: Department of Occupational and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen D-52074, Germany. pziegler@ukaachen.de.
authors.forename: Patrick
authors.initials: P
authors.lastname: Ziegler
authors.affiliation: Department of Occupational and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen D-52074, Germany. tkraus@ukaachen.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kraus
authors.affiliation: Medical Faculty, Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstrasse 30, Aachen D-52074, Germany. lrink@ukaachen.de.
authors.forename: Lothar
authors.initials: L
authors.lastname: Rink
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000187:drug effects; D003430:Cross-Sectional Studies; D004147:Dioxins / Q000097:blood* / Q000633:toxicity*; D055615:Electrical Equipment and Supplies; D004784:Environmental Monitoring; D005260:Female; D005858:Germany; D006801:Humans; D000922:Immunotoxins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000633:toxicity*; D059027:Recycling; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000187:drug effects; D055815:Young Adult
chemical_list: D004147:Dioxins; D000922:Immunotoxins; D011078:Polychlorinated Biphenyls
keywords: PCB; immune system; polychlorinated biphenyls