title: Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy.
abstract: Ultrasound (US) is one of the most commonly used clinical imaging techniques. However, the use of US and US-based intravenous agents extends far beyond imaging. In particular, there has been a surge in the fabrication of multimodality US contrast agents and theranostic US agents for cancer imaging and therapy. The unique interaction of US waves with microscale and nanoscale agents has attracted much attention in the development of contrast agents and drug-delivery vehicles. The dimensions of the agent not only dictate how it behaves in vivo, but also how it interacts with US for imaging and drug delivery. Furthermore, these agents are also unique due to their ability to convert from the nanoscale to the microscale and vice versa, having imaging and therapeutic utility in both dimensions. Here, we review multimodality and multifunctional US-based agents, according to their size, and also highlight recent developments in size conversion US agents. WIREs Nanomed Nanobiotechnol 2016, 8:796-813. doi: 10.1002/wnan.1398 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Princess Margaret Cancer Center and Techna Institute, University Health Network, Toronto, Ontario, Canada.|Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Huynh
authors.affiliation: Princess Margaret Cancer Center and Techna Institute, University Health Network, Toronto, Ontario, Canada.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Maneesha A
authors.initials: MA
authors.lastname: Rajora
authors.affiliation: Princess Margaret Cancer Center and Techna Institute, University Health Network, Toronto, Ontario, Canada. gang.zheng@uhnres.utoronto.ca.|Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. gang.zheng@uhnres.utoronto.ca.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. gang.zheng@uhnres.utoronto.ca.
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000627:therapeutic use*; D000068936:Theranostic Nanomedicine; D014463:Ultrasonography
chemical_list: D003287:Contrast Media