title: Vedolizumab: A novel anti-integrin drug for treatment of inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is the chronic inflammatory disorder of gastrointestinal tract consisting of two subtypes: Ulcerative colitis and Crohn's disease. IBD occurs due to infiltration of leukocytes in intestinal mucosa and derangements in intestinal barrier function. One of the most important steps in pathogenesis of IBD is the interactions between integrins on the surface of leukocyte. The α4β7 integrin expressing T-cell is an important leukocyte involved in pathogenesis and represents a new drug target for the treatment of IBD. Vedolizumab is a humanized monoclonal antibody, which acts against α4β7 integrin heterodimer and blocks the interaction of α4β7 integrin with MAdCAM-1. It prevents leukocyte binding to endothelial surface and its extravasation into affected tissue. The efficacy and safety of the vedolizumab have been established in many clinical studies. It has shown promising results in various clinical studies where a greater percentage of patients as compared to a placebo achieved and maintained clinical response, clinical remission, and corticosteroid-free clinical remission. Vedolizumab has been shown to be well tolerated with slightly higher risk of infections, headache, naspharyngitis as compared to placebo. This review focuses on the potential role of vedolizumab for the treatment of IBD.
authors.affiliation: Department of Pharmacology, All India Institutes of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Harmanjit
authors.initials: H
authors.lastname: Singh
authors.affiliation: Department of Pharmacology, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India.
authors.forename: Nipunjot
authors.initials: N
authors.lastname: Grewal
authors.affiliation: Department of Pharmacology, All India Institutes of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Ekta
authors.initials: E
authors.lastname: Arora
authors.affiliation: Department of Pharmacology, PGIMER, Chandigarh, India.
authors.forename: Harish
authors.initials: H
authors.lastname: Kumar
authors.affiliation: Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi, India.
authors.forename: Ashish Kumar
authors.initials: AK
authors.lastname: Kakkar
keywords: Crohn's disease; inflammatory bowel disease; integrins; ulcerative colitis