title: Contemporary outcomes after surgical aortic valve replacement with bioprostheses and allografts: a systematic review and meta-analysis.
abstract: Many observational studies have reported outcomes after surgical aortic valve replacement (AVR), but there are no recent systematic reviews and meta-analyses including all available bioprostheses and allografts. The objective of this study is to provide a comprehensive and up-to-date overview of the outcomes after AVR with bioprostheses and allografts reported in the last 15 years. We conducted a systematic literature review (PROSPERO register: CRD42015017041) of studies published between 2000-15. Inclusion criteria were observational studies or randomized controlled trials reporting on outcomes of AVR with bioprostheses (stented or stentless) or allografts, with or without coronary artery bypass grafting (CABG) or valve repair procedure, with study population size n ≥ 30 and mean follow-up length ≥5 years. Fifty-four bioprosthesis studies and 14 allograft studies were included, encompassing 55 712 and 3872 patients and 349 840 and 32 419 patient-years, respectively. We pooled early mortality risk and linearized occurrence rates of valve-related events, reintervention and late mortality in a random-effects model. Sensitivity, meta-regression and subgroup analyses were performed to investigate the influence of outliers on the pooled estimates and to explore sources of heterogeneity. Funnel plots were used to investigate publication bias. Pooled early mortality risks for bioprostheses and allografts were 4.99% (95% confidence interval [CI], 4.44-5.62) and 5.03% (95% CI, 3.61-7.01), respectively. The late mortality rate was 5.70%/patient-year (95% CI, 4.99-5.62) for bioprostheses and 1.68%/patient-year (95% CI, 1.23-2.28) for allografts. Pooled reintervention rates for bioprostheses and allografts were 0.75%/patient-year (95% CI, 0.61-0.91) and 1.87%/patient-year (95% CI, 1.52-2.31), respectively. There was substantial heterogeneity in most outcomes. Meta-regression analyses identified covariates that could explain the heterogeneity: implantation period, valve type, patient age, gender, pre-intervention New York Heart Association class III/IV, concomitant CABG, study design and follow-up length. There is possible publication bias in all outcomes. This comprehensive systematic review and meta-analysis provides an overview of the outcomes after AVR with bioprostheses and allografts reported during the last 15 years. The results of this study can support patients and doctors in the prosthetic valve choice and can be used in microsimulation models to predict patient outcomes and estimate the cost-effectiveness of AVR with bioprostheses or allografts compared with current and future heart valve prostheses.
authors.affiliation: Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands s.huygens@erasmusmc.nl.|Institute for Medical Technology Assessment, Erasmus University, Rotterdam, Netherlands.|Department of Health Policy and Management, Erasmus University, Rotterdam, Netherlands.
authors.forename: Simone A
authors.initials: SA
authors.lastname: Huygens
authors.affiliation: Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Mokhles
authors.affiliation: Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.
authors.forename: Milad
authors.initials: M
authors.lastname: Hanif
authors.affiliation: Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.
authors.forename: Jos A
authors.initials: JA
authors.lastname: Bekkers
authors.affiliation: Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.
authors.forename: Ad J J C
authors.initials: AJ
authors.lastname: Bogers
authors.affiliation: Institute for Medical Technology Assessment, Erasmus University, Rotterdam, Netherlands.|Department of Health Policy and Management, Erasmus University, Rotterdam, Netherlands.
authors.forename: Maureen P M H
authors.initials: MP
authors.lastname: Rutten-van Mölken
authors.affiliation: Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.
authors.forename: Johanna J M
authors.initials: JJ
authors.lastname: Takkenberg
mesh_terms: D064591:Allografts; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D006801:Humans; D016896:Treatment Outcome
keywords: Allografts; Aortic valve replacement; Bioprostheses; Homografts; Meta-analysis; Systematic review