title: HLA-DR3 antigen in the resistance to idiopathic dilated cardiomyopathy.
abstract: Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR3 antigen and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Studies were identified by searching the PUBMED and Embase database (starting from June 2015). A total of 19 case-control studies including 1378 cases and 10383 controls provided data on the association between HLA-DR3 antigen and genetic susceptibility to IDC. Overall, significantly decreased frequency of HLA-DR3 allele (OR=0.72; 95%CI=0.58-0.90; P=0.004) was found in patients with IDC compared with controls. When stratified by myocardial biopsy or non-biopsy cases, statistically decreased risk was found for IDC in myocardial biopsy cases (OR=0.69; 95%CI=0.57-0.84; P=0.0003). In the subgroup analysis by ethnicity, borderline statistically significantly decreased risk was found among Europeans from 12 case-control studies (OR=0.76; 95%CI=0.58-1.00; P=0.05). In conclusion, our results suggest that individuals with HLA-DR3 antigen may have a protective effect against IDC.
authors.affiliation: Department of Cardiology, Huashan Hospital, Fudan University, China.
authors.forename: B
authors.initials: B
authors.lastname: Jin
authors.affiliation: Department of Cardiology, Huashan Hospital, Fudan University, China.
authors.forename: B W
authors.initials: BW
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Huashan Hospital, Fudan University, China.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Wen
authors.affiliation: Department of Cardiology, Huashan Hospital, Fudan University, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Huashan Hospital, Fudan University, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhu
mesh_terms: D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006801:Humans; D009206:Myocardium / Q000473:pathology; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D015803:HLA-DR3 Antigen