title: Protective effect of Geraniol on the transgenic Drosophila model of Parkinson's disease.
abstract: The role of Geraniol was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. Geraniol at final concentration of 10, 20 and 40μM were mixed in the diet and the flies were allowed to feed on it for 24 days. The effect of geraniol was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbonyl, glutathione, dopamine content, and glutathione-S-transferase activity in the brains of transgenic Drosophila. The exposure of PD model flies to 10, 20 and 40μM of geraniol results in a significant delay in the loss of climbing ability (p<0.05), improved activity pattern reduced the oxidative stress (p<0.05) in the brains of transgenic Drosophila as compared to unexposed PD model flies. The results suggest that geraniol is potent in reducing the PD symptoms in transgenic Drosophila model of Parkinson's disease.
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. Electronic address: yasir_hasansiddique@rediffmail.com.
authors.forename: Yasir Hasan
authors.initials: YH
authors.lastname: Siddique
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Falaq
authors.initials: F
authors.lastname: Naz
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Jyoti
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Fahad
authors.initials: F
authors.lastname: Ali
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Ambreen
authors.initials: A
authors.lastname: Fatima
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.lastname: Rahul
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Saba
authors.initials: S
authors.lastname: Khanam
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D004330:Drosophila; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013729:Terpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000080462:Acyclic Monoterpenes; D010936:Plant Extracts; D020011:Protective Agents; D013729:Terpenes; C007836:geraniol
keywords: Drosophila; Geraniol; Parkinson’s disease