title: Analysis of Soluble Molecular Fibronectin-Fibrin Complexes and EDA-Fibronectin Concentration in Plasma of Patients with Atherosclerosis.
abstract: Atherosclerosis, a chronic vascular disease, leads to molecular events bound with interplaying processes of inflammation and coagulation. In the present study, fibronectin (FN), FN containing extra domain A (EDA-FN), frequency of occurrence, and relative amounts of soluble plasma FN-fibrin complexes were analyzed in 80 plasma samples of patients suspected of coronary artery disease based on clinical evaluation and changes in arteries found by computed tomographic coronary angiography. The study showed that in the plasma of the patients' group with high risk of coronary artery disease EDA-FN concentration was significantly higher (3.5 ± 2.5 mg/L; P < 0.025) and the molecular FN-fibrin complexes of 1000 kDa and higher occurred more often than in the groups of patients with mild risk of coronary artery disease and the normal age-matched. The increased level of EDA-FN and occurrence of FN-fibrin complexes could have a potential diagnostic value in the diagnosis and management of patients with coronary artery disease.
authors.affiliation: Department of Chemistry and Immunochemistry, Medical University of Wrocław, Bujwida 44a, 50-345, Wrocław, Poland. anna.lemanska-perek@umed.wroc.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Lemańska-Perek
authors.affiliation: Department of Chemistry and Immunochemistry, Medical University of Wrocław, Bujwida 44a, 50-345, Wrocław, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Krzyżanowska-Gołąb
authors.affiliation: Department of Chemistry and Immunochemistry, Medical University of Wrocław, Bujwida 44a, 50-345, Wrocław, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pupek
authors.affiliation: Provincial Specialist Hospital in Wrocław, Research and Development Center in Wrocław, Wrocław, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Klimeczek
authors.affiliation: Provincial Specialist Hospital in Wrocław, Research and Development Center in Wrocław, Wrocław, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Witkiewicz
authors.affiliation: Department of Chemistry and Immunochemistry, Medical University of Wrocław, Bujwida 44a, 50-345, Wrocław, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Kątnik-Prastowska
mesh_terms: D050197:Atherosclerosis / Q000097:blood*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000175:diagnosis; D005337:Fibrin / Q000378:metabolism*; D005353:Fibronectins / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D012306:Risk
chemical_list: C067625:FN1 protein, human; D005353:Fibronectins; C574442:extra domain A fibronectin, human; D005337:Fibrin
keywords: FN-fibrin complexes; atherosclerosis; fibronectin; fibronectin bearing EDA segment