title: The lymph node neutrophil.
abstract: Secondary lymphoid organs provide a specialized microenvironment tailored to foster communication between cells of the innate and adaptive immune systems. These interactions allow immune cells to coordinate multilayered defense against pathogens. Until recently dendritic cells and macrophages were thought to comprise the main innate immune cell subsets responsible for delivering signals that drive the adaptive immune response, while the function of neutrophils was largely confined to the innate immune system. However, the discovery of neutrophils in lymph nodes has raised the question of whether neutrophils might play a more extensive role not only in innate immunity per se, but also in coordinating the interactions between innate and adaptive immune responses. In this review we discuss the mechanisms and consequences of neutrophil recruitment to lymph nodes and how this recruitment influences subsequent immune responses both in situ and at distant sites.
authors.affiliation: Immunology Division, The Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Henry R
authors.initials: HR
authors.lastname: Hampton
authors.affiliation: Immunology Division, The Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address: t.chtanova@garvan.org.au.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Chtanova
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002450:Cell Communication / Q000276:immunology; D002470:Cell Survival / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility; D006801:Humans; D007113:Immunity, Innate; D008198:Lymph Nodes / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D018375:Neutrophil Activation / Q000235:genetics / Q000276:immunology; D020556:Neutrophil Infiltration / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D009928:Organ Specificity / Q000276:immunology
keywords: Adaptive immunity; Immune regulation; Infection; Lymph node; Lymphatic vessel; Migration; Neutrophil