title: Emerging Diversity of the Cobalamin-Dependent Methyltransferases Involving Radical-Based Mechanisms.
abstract: Cobalamins comprise a group of cobalt-containing organometallic cofactors that play important roles in cellular metabolism. Although many cobalamin-dependent methyltransferases (e.g., methionine synthase MetH) have been extensively studied, a new group of methyltransferases that are cobalamin-dependent and utilize radical chemistry in catalysis is just beginning to be appreciated. In this Concept article, we summarize recent advances in the understanding of the radical-based and cobalamin-dependent methyltransferases and discuss the functional and mechanistic diversity of this emerging class of enzymes.
authors.affiliation: Key Laboratory of Cell Activities and Stress Adaptations, (Ministry of Education), School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.|Department of Chemistry, Fudan University, Shanghai, 200433, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.affiliation: Key Laboratory of Cell Activities and Stress Adaptations, (Ministry of Education), School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Qien
authors.initials: Q
authors.lastname: Li
authors.affiliation: Key Laboratory of Cell Activities and Stress Adaptations, (Ministry of Education), School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.|Department of Chemistry, Fudan University, Shanghai, 200433, China.
authors.forename: Youli
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Chemistry, Fudan University, Shanghai, 200433, China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Chemistry, Fudan University, Shanghai, 200433, China.
authors.forename: Haocheng
authors.initials: H
authors.lastname: Qianzhu
authors.affiliation: Department of Chemistry, Fudan University, Shanghai, 200433, China. qizhang@sioc.ac.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D008745:Methylation; D008780:Methyltransferases / Q000737:chemistry* / Q000235:genetics; D008956:Models, Chemical; D013845:Thienamycins / Q000096:biosynthesis; D013883:Thiostrepton / Q000096:biosynthesis; D014805:Vitamin B 12 / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D008780:Methyltransferases; D013883:Thiostrepton; D014805:Vitamin B 12; C015537:thienamycin
keywords: biosynthesis; cobalamins; methyltransferases; radical SAM; vitamin B12