title: Decreased number of orbital sulci in schizophrenia spectrum disorders.
abstract: An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: tsutomu@med.u-toyama.ac.jp.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nishikawa
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Takayanagi
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Furuichi
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Kido
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Sasabayashi
authors.affiliation: Department of Radiology, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Kyo
authors.initials: K
authors.lastname: Noguchi
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000473:pathology; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000473:pathology; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000473:pathology; D012569:Schizotypal Personality Disorder / Q000000981:diagnostic imaging* / Q000473:pathology; D055815:Young Adult
keywords: Magnetic resonance imaging; Orbitofrontal cortex; Schizotypal disorder