title: Left Ventricular Global Strain for Estimating Relaxation and Filling Pressure　- A Multicenter Study.
abstract: BACKGROUND
  Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter - strain or strain rate - and which direction of myocardial deformation - longitudinal or circumferential - is the most useful marker of LV relaxation and filling pressure.
  
  
  RESULTS
  We conducted a prospective multicenter study and compared the correlation of tissue Doppler- and STE-derived parameters with the time constant of LV pressure decay (τ) and LV mean diastolic pressure (MDP) in 77 patients. The correlation of early-diastolic mitral annular velocity (e´) with τ was weak (r=-0.32, P<0.01), and that of peak longitudinal strain (LS) was the strongest (r=-0.45, P<0.001) among the STE-derived parameters. There was a modest correlation between LVMDP and the ratio of early-diastolic inflow velocity (E) to e´ (E/e´) (r=0.50, P<0.001). In contrast, the ratio of E to LS (E/LS) correlated strongly with LVMDP (r=0.70, P<0.001). The correlation of E/LS with LVMDP was significantly better than that for E/e´ (P<0.01). Receiver-operating characteristic analysis showed that E/LS had the largest area under the curve for distinguishing elevated LVMDP (E/LS 0.86, E/e´ 0.74, E/A 0.67).
  
  
  CONCLUSIONS
  STE-derived longitudinal parameters correlated well with LV relaxation and filling pressure. In particular, E/LS could be more accurate than E/e´ for estimating LV filling pressure. (Circ J 2016; 80: 1163-1170).
authors.affiliation: Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine.
authors.forename: Taichi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwano
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakabachi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Sakakibara
authors.forename: Kazunori
authors.initials: K
authors.lastname: Okada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Murai
authors.forename: Hisao
authors.initials: H
authors.lastname: Nishino
authors.forename: Kenya
authors.initials: K
authors.lastname: Kusunose
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Watanabe
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ishizu
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Wakami
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Yamada
authors.forename: Kaoru
authors.initials: K
authors.lastname: Dohi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Seo
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohte
authors.forename: Taisei
authors.initials: T
authors.lastname: Mikami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsui
mesh_terms: D000328:Adult; D003971:Diastole; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D016277:Ventricular Function, Left; D017725:Ventricular Pressure