title: TPRV-1 expression in human preeclamptic placenta.
abstract: Preeclampsia is a multisystem disorder unique to human pregnancy, characterized by abnormal placentation. Although its causes remain unclear, it is known that the expression of several transporters is altered. Transient receptor potential vanilloid 1 (TRPV-1) is a nonselective cation channel, present in human placenta. Here, we evaluated the expression of TRPV-1 in preeclamptic placentas. We observed a deregulation in TRPV-1 expression in these placentas which may explain the impaired Ca(2+) homeostasis found in preeclampsia.
authors.affiliation: Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address: noraalicia.martinez@gmail.com.
authors.forename: Nora
authors.initials: N
authors.lastname: Martínez
authors.affiliation: Laboratorio de Fisiopatología Placentaria, CEFYBO-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Cyntia E
authors.initials: CE
authors.lastname: Abán
authors.affiliation: Departamento de Ginecología y Obstetricia, Unidad de Embarazo de Alto Riesgo, Centro de Estudios Médicos e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina.
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Leguizamón
authors.affiliation: Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina; Cátedra de Biología Celular y Molecular, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
authors.forename: Alicia E
authors.initials: AE
authors.lastname: Damiano
authors.affiliation: Laboratorio de Fisiopatología Placentaria, CEFYBO-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Mariana G
authors.initials: MG
authors.lastname: Farina
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D050916:TRPV Cation Channels / Q000378:metabolism*; D055815:Young Adult
chemical_list: D050916:TRPV Cation Channels; C494482:TRPV1 protein, human
keywords: Preeclampsia; TRPV-1; Trophoblast