title: Assessment of trait anxiety and prediction of changes in state anxiety using functional brain imaging: A test-retest study.
abstract: Anxiety is a multidimensional construct that includes stable trait anxiety and momentary state anxiety, which have a combined effect on our mental and physical well-being. However, the relationship between intrinsic brain activity and the feeling of anxiety, particularly trait and state anxiety, remain unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) (amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo)) to determine the effects of intrinsic brain activity on stable inter-individual trait anxiety and intra-individual state anxiety variability in a cross-sectional and test-retest study. We found that at both time points, the trait anxiety score was significantly associated with intrinsic brain activity (both the ALFF and ReHo) in the right ventral medial prefrontal cortex (vmPFC) and ALFF of the dorsal anterior cingulate cortex/anterior midcingulate cortex (dACC/aMCC). More importantly, the change in intrinsic brain activity in the right insula was predictive of intra-individual state anxiety variability over a 9-month interval. The test-retest nature of this study's design could provide an opportunity to distinguish between the intrinsic brain activity associated with state and trait anxiety. These results could deepen our understanding of anxiety from a neuroscientific perspective.
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Tian
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Dongtao
authors.initials: D
authors.lastname: Wei
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Kangcheng
authors.initials: K
authors.lastname: Wang
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Junyi
authors.initials: J
authors.lastname: Yang
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Meng
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Electronic and Information Engineering, Chongqing 400715, China. Electronic address: liugy@swu.edu.cn.
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Liu
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Department of Psychology, Southwest University, Chongqing 400715, China. Electronic address: qiuj318@swu.edu.cn.
authors.forename: Jiang
authors.initials: J
authors.lastname: Qiu
mesh_terms: D001007:Anxiety / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009473:Neuronal Plasticity; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Insula; State anxiety; Test–retest study; Trait anxiety; Ventral medial prefrontal cortex