title: The spectrum-effect relationship-a rational approach to screening effective compounds, reflecting the internal quality of Chinese herbal medicine.
abstract: Since the chromatographic fingerprint was introduced, it has been accepted by many countries to assess the quality and authenticity of Chinese herbal medicine (CHM). However, solely using the chromatographic fingerprint to assay numerous chemicals is not suitable for the assessment of the whole internal quality and pharmacodynamics of CHM. Consequently, it is necessary to develop a rational approach to connecting the chromatographic fingerprint with effective components to assess the internal quality of CHM. For this purpose, a spectrum-effect relationship theory was proposed and accepted as a new method for the assessment of CHM because of its potential use to screen effective components from CHM. In this paper, we systematically reviewed the application of the spectrum-effect relationship theory in the research of CHM, including research mentality, different chromatographic analysis techniques, data processing technologies, and structure determination.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 10029, China.
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Zhu
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 10029, China.
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Lin
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 10029, China.
authors.forename: Ming-Liang
authors.initials: ML
authors.lastname: Xiao
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 10029, China.
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Niu
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 10029, China. Electronic address: zhangbing6@263.net.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
mesh_terms: D002845:Chromatography; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000493:pharmacokinetics; D015233:Models, Statistical; D011786:Quality Control
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Chinese herbal medicine; Chromatographic fingerprint; Spectrum-effect relationship