title: Two phases of aging separated by the Smurf transition as a public path to death.
abstract: Aging's most obvious characteristic is the time dependent increase of an individual's probability to die. This lifelong process is accompanied by a large number of molecular and physiological changes. Although numerous genes involved in aging have been identified in the past decades its leading factors have yet to be determined. To identify the very processes driving aging we have developed in the past years an assay to identify physiologically old individuals in a synchronized population of Drosophila melanogaster. Those individuals show an age-dependent increase of intestinal permeability followed by a high risk of death. Here we show that this physiological marker of aging is conserved in 3 invertebrate species Drosophila mojavensis, Drosophila virilis, Caenorhabditis elegans as well as in 1 vertebrate species Danio rerio. Our findings suggest that intestinal barrier dysfunction may be an important event in the aging process conserved across a broad range of species, thus raising the possibility that it may also be the case in Homo sapiens.
authors.affiliation: Equipe CASBAH "Comparative Analysis of Stem cells, Brain Anatomy and Homeostasis", Neuroscience Paris-Saclay Institute (Neuro-PSI), UMR 9197, CNRS, Gif-sur-Yvette, France.
authors.forename: E
authors.initials: E
authors.lastname: Dambroise
authors.affiliation: Ecole Normale Supérieure de Lyon - CNRS - Université de Lyon Claude Bernard - Institut de Génomique Fonctionnelle de Lyon /UMR5262 46, Allée d'Italie, 69364 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Monnier
authors.affiliation: Ecole Normale Supérieure de Lyon - CNRS - Université de Lyon Claude Bernard - Institut de Génomique Fonctionnelle de Lyon /UMR5262 46, Allée d'Italie, 69364 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Ruisheng
authors.affiliation: Ecole Normale Supérieure de Lyon - CNRS - Université de Lyon Claude Bernard - Institut de Génomique Fonctionnelle de Lyon /UMR5262 46, Allée d'Italie, 69364 Lyon, France.
authors.forename: H
authors.initials: H
authors.lastname: Aguilaniu
authors.affiliation: Equipe CASBAH "Comparative Analysis of Stem cells, Brain Anatomy and Homeostasis", Neuroscience Paris-Saclay Institute (Neuro-PSI), UMR 9197, CNRS, Gif-sur-Yvette, France.
authors.forename: J-S
authors.initials: JS
authors.lastname: Joly
authors.affiliation: Unité de Biologie Fonctionnelle et Adaptative (BFA) UMR8251 - CNRS - Université Diderot, Sorbonne Paris Cité, 4 Rue Marie Andrée Lagroua Weill Hallé, 75013, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Tricoire
authors.affiliation: Unité de Biologie Fonctionnelle et Adaptative (BFA) UMR8251 - CNRS - Université Diderot, Sorbonne Paris Cité, 4 Rue Marie Andrée Lagroua Weill Hallé, 75013, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Rera
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D017124:Conserved Sequence; D003643:Death; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D007422:Intestines / Q000502:physiology*; D008297:Male; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D029961:Zebrafish Proteins; C492378:Smurf protein, Drosophila; D044767:Ubiquitin-Protein Ligases