title: Omega 3 Fatty Acids Supplementation and Oxidative Stress in HIV-Seropositive Patients. A Clinical Trial.
abstract: HIV-seropositive patients show high incidence of coronary heart disease and oxidative stress has been described as relevant key in atherosclerosis development. The aim of this study was to assess the effect of omega 3 fatty acids on different markers of oxidative stress in HIV-seropositive patients. We performed a randomized parallel controlled clinical trial in The Instituto Mexicano del Seguro Social, a public health hospital. 70 HIV-seropositive patients aged 20 to 55 on clinical score A1, A2, B1 or B2 receiving highly active antiretroviral therapy (HAART) were studied. They were randomly assigned to receive omega 3 fatty acids 2.4 g (Zonelabs, Marblehead MA) or placebo for 6 months. At baseline and at the end of the study, anthropometric measurements, lipid profile, glucose and stress oxidative levels [nitric oxide catabolites, lipoperoxides (malondialdehyde plus 4-hydroxialkenals), and glutathione] were evaluated. Principal HAART therapy was EFV/TDF/FTC (55%) and AZT/3TC/EFV (15%) without difference between groups. Treatment with omega 3 fatty acids as compared with placebo decreased triglycerides (-0.32 vs. 0.54 mmol/L; p = 0.04), but oxidative stress markers were not different between groups.
authors.affiliation: Department of Education and Research, UMAE HE No.1, Bajio, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Norma
authors.initials: N
authors.lastname: Amador-Licona
authors.affiliation: Department of Education and Research, UMAE HE No.1, Bajio, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Díaz-Murillo
authors.affiliation: Laboratory of oxidative stress & Pathology, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Mexico.
authors.forename: Genaro
authors.initials: G
authors.lastname: Gabriel-Ortiz
authors.affiliation: Department of Chemistry, University of Guadalajara, Guadalajara, Mexico.
authors.forename: Fermín P
authors.initials: FP
authors.lastname: Pacheco-Moises
authors.affiliation: Department of Education and Research, UMAE HE No.1, Bajio, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Texar A
authors.initials: TA
authors.lastname: Pereyra-Nobara
authors.affiliation: University DeLa Salle Bajio, Leon, Mexico.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Guízar-Mendoza
authors.affiliation: Department of Research, University of Guanajuato, Leon, Mexico.
authors.forename: Gloria
authors.initials: G
authors.lastname: Barbosa-Sabanero
authors.affiliation: Institute of Research on Inflammation, Guadalajara, Jalisco, Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Orozco-Aviña
authors.affiliation: Department of Education and Research, UMAE HE No.1, Bajio, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Moreno-Martínez
authors.affiliation: Department of Education and Research, UMAE HE No.1, Bajio, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Luna-Montalbán
authors.affiliation: Laboratory of oxidative stress & Pathology, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Vázquez-Valls
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D002784:Cholesterol / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006678:HIV / Q000187:drug effects / Q000472:pathogenicity; D015658:HIV Infections / Q000178:diet therapy* / Q000188:drug therapy / Q000821:virology; D006679:HIV Seropositivity / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D019562:Viral Load / Q000187:drug effects
chemical_list: D015525:Fatty Acids, Omega-3; D009569:Nitric Oxide; D002784:Cholesterol; D005978:Glutathione