title: miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence.
abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression.
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Sadaf
authors.initials: S
authors.lastname: Atarod
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Mohammed Mahid
authors.initials: MM
authors.lastname: Ahmed
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Lendrem
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Kim Frances
authors.initials: KF
authors.lastname: Pearce
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Wei
authors.initials: W
authors.lastname: Cope
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Jean
authors.initials: J
authors.lastname: Norden
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Xiao-Nong
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Collin
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Anne Mary
authors.initials: AM
authors.lastname: Dickinson
keywords: acute graft-versus-host disease; allogeneic hematopoietic stem cell transplantation; biological markers; graft-versus-host disease; microRNAs