title: ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium obtusissmum.
abstract: Six new ent-labdane diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 μM.
authors.forename: Quírico A
authors.initials: QA
authors.lastname: Castillo
authors.affiliation: Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Triana
authors.affiliation: Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Eiroa
authors.affiliation: Florida Center of Excellence for Drug Discovery and Innovation (CDDI-USF), University of South Florida , Tampa, Florida 33620, United States.
authors.forename: Laurent
authors.initials: L
authors.lastname: Calcul
authors.affiliation: Florida Center of Excellence for Drug Discovery and Innovation (CDDI-USF), University of South Florida , Tampa, Florida 33620, United States.|Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33612, United States.
authors.forename: Edwin
authors.initials: E
authors.lastname: Rivera
authors.affiliation: Florida Center of Excellence for Drug Discovery and Innovation (CDDI-USF), University of South Florida , Tampa, Florida 33620, United States.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Wojtas
authors.affiliation: BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna , 38206 La Laguna, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
authors.affiliation: Florida Center of Excellence for Drug Discovery and Innovation (CDDI-USF), University of South Florida , Tampa, Florida 33620, United States.
authors.forename: Lise
authors.initials: L
authors.lastname: Boberieth
authors.affiliation: Biointerfaces Institute, McMaster University , Engineering Technology Building, Room 413, 1280 Main Street West, Hamilton, ON L8S 0A3, Canada.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Keramane
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada , Las Vegas, Nevada 89154, United States.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Abel-Santos
authors.forename: Luis A
authors.initials: LA
authors.lastname: Báez
authors.forename: Evelyn A
authors.initials: EA
authors.lastname: Germosén
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036602:Eupatorium / Q000737:chemistry*; D006801:Humans; D008070:Lipopolysaccharides; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; C433017:labdane