title: Role of microRNA in liver regeneration.
abstract: BACKGROUND
  Liver regeneration is a complex process. microRNAs (miRNAs) are short, single-stranded RNAs that modify gene expression at the post-transcriptional level. Recent investigations have revealed that miRNAs are closely linked to liver regeneration.
  
  
  METHODS
  All included studies were obtained from PubMed, Embase, the ScienceDirect databases and Web of Science, with no limitation on publication year. Only studies published in English were considered.
  
  
  RESULTS
  We grouped studies that involved miRNA and liver regeneration into two groups: miRNAs as promoters and as inhibitors of liver regeneration. We summarized the relevant miRNAs separately from the related pathways.
  
  
  CONCLUSIONS
  Blocking or stimulating the pathways of miRNAs in liver regeneration may be novel therapeutic strategies in future regeneration-related liver managements. We may discover additional chemotherapy targets of miRNA.
authors.affiliation: Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. xumingqing0018@163.com.
authors.forename: Peng-Sheng
authors.initials: PS
authors.lastname: Yi
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Xu
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008115:Liver Regeneration / Q000187:drug effects / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs