title: Two new lignans from the aerial part of Vitex negundo.
abstract: A new phenyldihydronaphthalene-type lignan, (3R,4S)-6-hydroxy-4-(4-hydroxy- 3-methoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2-naphthaldehyde-3a-O-β-d-glucopyranoside (1), and a new phenylnaphthalene-type lignan, 6,7,4'-trihydroxy-3'-methoxy-2,3- cycloligna-1,4-dien-2a,3a-olide (2), along with 10-known lignan derivatives (3-12) were isolated from the aerial part of Vitex negundo var. heterophylla. Their structures were established by comprehensive 1D- and 2D-NMR spectroscopic analyses.
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Xiu-Fang
authors.initials: XF
authors.lastname: Nie
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Yu
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tao
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: b Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Ding
authors.affiliation: b Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.
authors.forename: Xin-Chi
authors.initials: XC
authors.lastname: Feng
authors.affiliation: b Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Jiang
authors.affiliation: b Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zheng
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Chen
authors.affiliation: b Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry*; D020950:Vitex / Q000737:chemistry*
chemical_list: C000613294:(3R,4S)-6-hydroxy-4-(4-hydroxy- 3-methoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2-naphthaldehyde-3alpha-O-beta-D-glucopyranoside; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D017705:Lignans
keywords: Verbenaceae; Vitex negundo var. heterophylla; lignan; vitecannaside; vitexdoin