title: Preparation and characterization of the pH and thermosensitive magnetic molecular imprinted nanoparticle polymer for the cancer drug delivery.
abstract: A novel pH and thermosensitive magnetic nanoparticle polymer composite [poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX)] was synthesized by radical polymerization of N-isopropylacrylamide (NIPAAM) and the methacrylate functionalized Fe3O4 nanoparticles/DOX complex using AIBN and EGDMA, and used as a drug carrier for the DOX drug delivery. Formation of poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX) was confirmed by FTIR, XRD, UV-Vis, VSM, TGA-DTA and SEM. The results showed the high DOX loading controls release. Moreover, it showed the lower critical solution temperature of 40°C which can be beneficial in cancer drug delivery, since the temperature of cancer cells is higher than normal ones, and DOX can be released selectively in cancer cells.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran; Mofateh Campus, Farhangian University, Tehran 1873676541, Iran.
authors.forename: Sharif
authors.initials: S
authors.lastname: Kaamyabi
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran. Electronic address: davood.habibi@gmail.com.
authors.forename: Davood
authors.initials: D
authors.lastname: Habibi
authors.affiliation: Department of Chemistry, Shahid Beheshti University, G.C., Tehran 1983963113, Iran.
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Amini
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D054802:Molecular Imprinting; D053758:Nanoparticles; D011108:Polymers / Q000008:administration & dosage*; D013057:Spectrum Analysis / Q000379:methods; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers
keywords: Cancer drug delivery; Doxorubicin; Fe(3)O(4) magnetic nanoparticles; pH and thermosensitive composite