title: Carotid Intima-Media Thickness as the Cardiometabolic Risk Indicator in Patients with Nonfunctional Adrenal Mass and Metabolic Syndrome Screening.
abstract: BACKGROUND
  Our purpose was to show the association of adrenal incidentaloma and metabolic syndrome in consideration of the studies and to detect the increase in the carotid intima-media thickness which is regarded as the precessor of atherosclerosis.
  
  
  METHODS
  Eighty-one patients who were diagnosed with adrenal mass were included in the study. Hormonal evaluation, insulin rezistance measurement with the HOMA-IR and 1-mg DST were performed of all patients. The patients were classified as follows: mass size <3 cm (K1) and mass size of at least 3 cm (K2). Echocardiography and carotid intima-media thickness of the patients were measured using B-mode ultrasound. Thirty-three healthy individuals were enrolled as the control group.
  
  
  RESULTS
  Mass size of 64.19% K1, while mass size of the remainder (35.81%) K2 was calculated. Five of the patients with adrenal mass were detected to have subclinical Cushing syndrome. The remaining 76 patients were accepted as nonfunctional. It was seen with regard to metabolic and biochemical parameters that plasma glucose (p=0.01), insulin (p=0.00) and triglyceride (p=0.012) values of all patients were significantly high compared to those of the control group. It was detected that measured heart rate (p=0.00), end-diastolic diameter (p=0.02), end-systolic diameter (p=0.014) and carotid intima-media thickness (p=0.00) values of the patients with adrenal mass were significantly higher than those of the healthy control group.
  
  
  CONCLUSIONS
  We found that the increased insulin resistance, increased risk of cardiovascular disease with the increase in the thickness of carotid intima-media and diastolic disfunction parameters, although the patients with adrenal incidentaloma are nonfunctional.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Cukurova University, Medical Faculty, Adana, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Evran
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Cukurova University, Medical Faculty, Adana, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Akkuş
authors.affiliation: Department of Cardiology, Cukurova University, Medical Faculty, Adana, Turkey.
authors.forename: İlayda
authors.initials: İ
authors.lastname: Berk Bozdoğan
authors.affiliation: Department of Cardiology, Cukurova University, Medical Faculty, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gök
authors.affiliation: Department of Cardiology, Cukurova University, Medical Faculty, Adana, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Deniz
authors.affiliation: Department of Cardiology, Cukurova University, Medical Faculty, Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sert
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Cukurova University, Medical Faculty, Adana, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Tetiker
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000150:complications / Q000378:metabolism*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003480:Cushing Syndrome / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D003710:Demography; D004562:Electrocardiography; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008403:Mass Screening; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D006728:Hormones