title: Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia.
abstract: OBJECTIVE
  To investigate the related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia.
  
  
  METHODS
  One hundred and ten patients with primary hypertension and hyperhomocysteinemia (homocysteine levels >10 μmol/L) were enrolled into this study, ages from 18 years to 75 years. They were divided into the normal serum uric acid group which contained 74 cases patients (41 cases of male and 33 cases of female) and the hyperuricemia group which contained 36 cases patients (20 cases of male and 16 cases of female). Plasma concentrations of homocysteine, serum uric acid, serum folic acid, blood sugar, triglyceride, total cholesterol, serum low density lipoprotein cholesterol, serum high density lipoprotein cholesterol, blood urea nitrogen, and creatinine were detected in these patients, and the deference of them between the two groups was compared. And then the risk factors of serum uric acid with univariate analysis and multivariate analysis by logistic regression analysis were analyzed.
  
  
  RESULTS
  The result of multivariate analysis showed that the incidence of serum uric acid in patients with primary hypertension and hyperhomocysteinemia had significant relationships with systolic blood pressure (OR [odds ratio]: 1.132, 95%CI [confidence interval]: 1.003~1.290, p = 0.043), diastolic blood pressure (OR: 1.353 95%CI: 1.023~1.789, p = 0.034, homocysteine (OR: 1.264, 95%CI: 1.016~1.573, p = 0.035), triglyceride (OR: 9.726, 95%CI: 1.288~73.466, p = 0.027), and creatinine (OR: 1.031, 95%CI: 1.005~1.508, p = 0.018).
  
  
  CONCLUSIONS
  The indices of systolic blood pressure, diastolic blood pressure, homocysteine, triglyceride, and creatinine were important risk factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia. It is of great significance to measure multiple risk factors in patients with primary hypertension and hyperhomocysteinemia.
authors.affiliation: a Graduate Studies of Guangzhou Medical University , Guangzhou , Guangdong , China.
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
authors.affiliation: b Department of Cardiology of Hainan NO.3 Province People's Hospital , Sanya , Hainan , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.affiliation: b Department of Cardiology of Hainan NO.3 Province People's Hospital , Sanya , Hainan , China.
authors.forename: Chang
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D000075222:Essential Hypertension; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000453:epidemiology; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D006710:Homocysteine; D014527:Uric Acid; D002784:Cholesterol; D003404:Creatinine
keywords: Hyperhomocysteinemia; hypertension; hyperuricemia; risk factors; serum uric acid