title: [Development of lipids and carbohydrates metabolism disorders caused by drinkable water with high content of chlorine organic compounds].
abstract: Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders. Individual risk of endocrine disorders (ICD: E67.8 excessive nutrition and E66.0 obesity) in these individuals is higher than in general population exposed to chloroform at residence (HQ1.72). Serum serotonin level, that is functionally connected with HTR2A gene, is 1.3 times lower vs. the reference group value.
authors.forename: K P
authors.initials: KP
authors.lastname: Luzhetsky
authors.forename: O Yu
authors.initials: OY
authors.lastname: Ustinova
authors.forename: P Z
authors.initials: PZ
authors.lastname: Shur
authors.forename: D A
authors.initials: DA
authors.lastname: Kiryanov
authors.forename: O V
authors.initials: OV
authors.lastname: Dolgikh
authors.forename: v M
authors.initials: vM
authors.lastname: Chigvintsev
authors.forename: A Ya
authors.initials: AY
authors.lastname: Perevalov
mesh_terms: D050260:Carbohydrate Metabolism / Q000187:drug effects* / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002725:Chloroform / Q000009:adverse effects* / Q000032:analysis / Q000097:blood; D060766:Drinking Water / Q000737:chemistry* / Q000592:standards; D004700:Endocrine System Diseases / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D005260:Female; D006801:Humans; D052439:Lipid Metabolism Disorders / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008962:Models, Theoretical; D009765:Obesity / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D012701:Serotonin / Q000097:blood; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis / Q000097:blood
chemical_list: D060766:Drinking Water; D044402:Receptor, Serotonin, 5-HT2A; D014874:Water Pollutants, Chemical; D012701:Serotonin; D002725:Chloroform