title: Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles.
abstract: The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline-pyrrolidine/pyrrolothiazole/indolizine-oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai 625 021, Tamil Nadu India.
authors.forename: Remani Vasudevan
authors.initials: RV
authors.lastname: Sumesh
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai 625 021, Tamil Nadu India.
authors.forename: Muthumani
authors.initials: M
authors.lastname: Muthu
authors.affiliation: Department of Chemistry, College of Science, King Saud University , P.O. Box 2455, Riyadh 11451, Saudi Arabia.
authors.forename: Abdulrahman I
authors.initials: AI
authors.lastname: Almansour
authors.affiliation: Department of Chemistry, College of Science, King Saud University , P.O. Box 2455, Riyadh 11451, Saudi Arabia.
authors.forename: Raju
authors.initials: R
authors.lastname: Suresh Kumar
authors.affiliation: Department of Chemistry, College of Science, King Saud University , P.O. Box 2455, Riyadh 11451, Saudi Arabia.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Arumugam
authors.affiliation: Department of Physics, University College of Engineering, Anna University Constituent College , Nagercoil 629 004, Tamil Nadu India.
authors.forename: S
authors.initials: S
authors.lastname: Athimoolam
authors.affiliation: Department of Physics, University College of Engineering, Anna University Constituent College , Nagercoil 629 004, Tamil Nadu India.
authors.forename: E Arockia
authors.initials: EA
authors.lastname: Jeya Yasmi Prabha
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai 625 021, Tamil Nadu India.
authors.forename: Raju Ranjith
authors.initials: RR
authors.lastname: Kumar
mesh_terms: D001391:Azo Compounds; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D061565:Cycloaddition Reaction / Q000379:methods*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D011804:Quinolines / Q000138:chemical synthesis*; D054852:Small Molecule Libraries / Q000138:chemical synthesis; D013141:Spiro Compounds; D013237:Stereoisomerism; D013882:Thiosemicarbazones
chemical_list: D001391:Azo Compounds; D006571:Heterocyclic Compounds; D011804:Quinolines; D054852:Small Molecule Libraries; D013141:Spiro Compounds; D013882:Thiosemicarbazones; C512188:azomethine
keywords: 1,3-dipolar cycloaddition; azomethine ylide; isatin; pyrazolo[3,4-b]quinoline; spiro-oxindole; spiro-pyrrolidine; α-amino acid