title: INTRA-ARTERIAL INFUSIONS AND DOPLEROGRAPIC CONTROL FOR COMPLEX TREATMENT OF UPPER AND MIDDLE FACIAL ZONES, CONCOMITANT WITH TRAUMATIC CRANIOCEREBRAL INJURIES.
abstract: Maxillofacial traumatic injuries concomitant with craniocerebral trauma are still considered as an actual problem in emergency medicine. For this category of patients one of the dangerous and severe complications is development of inflammatory process in the injured areas. Fracture lines of upper and middle facial zones pass through the accessory sinuses of the nose, maxillary/upper dental arch area and are considered to be open and infected fractures. Combination of these fractures with craniocerebral injuries and especially, with open traumas creates predisposition for development of inflammatory processes in CNS that can result in heavy outcome. 29 patients (among them 5-females and 24 -males) with severe and open craniofacial fractures were observed by the authors. For prevention of inflammatory complications in complex treatment of the patients, intra-arterial infusions of therapeutic agents (wide spectrum of antibiotics, Heparin) were used for stimulation of reparative regeneration in fractured fragments of facial bones. After the main surgical interventions (neurosurgery, surgery of facial bones) sanitation of infected centers (accessory sinuses of the nose, oral cavity) and catheterization of external carotid arteries through the temporal arteries were performed. According to the severity of the trauma and its preferential localization, catheterization of carotid arteries was conducted unilaterally (12 cases) or bilaterally (17 cases). Insertion depth through femoral artery was 6-8 cm. Catheter was stayed in the artery for 7-8 days. Intra-arterial infusions were carried out in the morning and evening. Therapeutic agents for arterial infusion included: antibiotic (Rocephin and its analogues), Heparin. To determine the effectiveness of vascular therapy dopplerography of external carotid artery, its branches and supratrochlear artery was performed. Dopplerography of supratrochlear artery, which is the branch of internal carotid artery, was conducted to detect the impact of therapeutic agents, administered in external carotid artery, on the internal carotid artery. During the treatment of complicated concomitant craniofacial injuries in a sequential order, development of inflammatory processes was not observed even in the patients with basic inflammatory processes in accessory sinuses of the nose. After infusion of therapeutic agents to external carotid artery, dopplerographically, sharp increase in blood flow in main artery and its branches, indicates to the stimulation of microcirculation that serves as a guarantee for osteogenic type healing of fractured fragments.
authors.affiliation: Tbilisi State Medical University, Direction of Surgical Stomatology; LTD "High Technology Medical Center - University Clinic", Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Lagvilava
authors.affiliation: Tbilisi State Medical University, Direction of Surgical Stomatology; LTD "High Technology Medical Center - University Clinic", Georgia.
authors.forename: Z
authors.initials: Z
authors.lastname: Gvenetadze
authors.affiliation: Tbilisi State Medical University, Direction of Surgical Stomatology; LTD "High Technology Medical Center - University Clinic", Georgia.
authors.forename: E
authors.initials: E
authors.lastname: Gibradze
authors.affiliation: Tbilisi State Medical University, Direction of Surgical Stomatology; LTD "High Technology Medical Center - University Clinic", Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Danelia
authors.affiliation: Tbilisi State Medical University, Direction of Surgical Stomatology; LTD "High Technology Medical Center - University Clinic", Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Gvenetadze
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D002342:Carotid Artery, External / Q000000981:diagnostic imaging; D002443:Ceftriaxone / Q000627:therapeutic use*; D006259:Craniocerebral Trauma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D005145:Face; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007261:Infusions, Intra-Arterial; D008297:Male; D008446:Maxillofacial Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy; D018608:Ultrasonography, Doppler
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D002443:Ceftriaxone; D006493:Heparin