title: Nucleic acid detection in the diagnosis and prevention of schistosomiasis.
abstract: Schistosomiasis is an important zoonotic parasitic disease that causes serious harms to humans and animals. Surveillance and diagnosis play key roles in schistosomiasis control, however, current techniques for surveillance and diagnosis of the disease have limitations. As genome data for parasites are increasing, novel techniques for detection incorporating nucleotide sequences are receiving widespread attention. These sensitive, specific, and rapid detection methods are particularly important in the diagnosis of low-grade and early infections, and may prove to have clinical significance. This paper reviews the progress of nucleic acid detection in the diagnosis and prevention of schistosomiasis, including such aspects as the selection of target genes, and development and application of nucleic acid detection methods.
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.|Key Laboratory of Tropical Disease Control, Ministry of Education, Guangzhou, 510080, China.|Department of Pathogenic Biology, Medical School, Xizang Minzu University, Xianyang, 712082, China.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.|Key Laboratory of Tropical Disease Control, Ministry of Education, Guangzhou, 510080, China.
authors.forename: Lan-Gui
authors.initials: LG
authors.lastname: Song
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.|Key Laboratory of Tropical Disease Control, Ministry of Education, Guangzhou, 510080, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.|Key Laboratory of Tropical Disease Control, Ministry of Education, Guangzhou, 510080, China.
authors.forename: Jin-Yi
authors.initials: JY
authors.lastname: Liang
authors.affiliation: Department of Pathogenic Biology, Medical School, Xizang Minzu University, Xianyang, 712082, China.
authors.forename: Dong-Ya
authors.initials: DY
authors.lastname: Yuan
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. wuzhd@mail.sysu.edu.cn.|Key Laboratory of Tropical Disease Control, Ministry of Education, Guangzhou, 510080, China. wuzhd@mail.sysu.edu.cn.
authors.forename: Zhong-Dao
authors.initials: ZD
authors.lastname: Wu
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. lvzhiyue@mail.sysu.edu.cn.|Key Laboratory of Tropical Disease Control, Ministry of Education, Guangzhou, 510080, China. lvzhiyue@mail.sysu.edu.cn.
authors.forename: Zhi-Yue
authors.initials: ZY
authors.lastname: Lv
mesh_terms: D000818:Animals; D018509:DNA, Helminth / Q000235:genetics; D005243:Feces / Q000469:parasitology; D006801:Humans; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D012547:Schistosoma / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D012552:Schistosomiasis / Q000175:diagnosis / Q000469:parasitology* / Q000517:prevention & control
chemical_list: D018509:DNA, Helminth
keywords: Diagnosis; Nucleic acid detection; S. haematobium; S. mansoni; Schistosoma japonicum