title: Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet.
abstract: This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, PR China. jmlin@tsinghua.edu.cn and John A. Paulson School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02139, USA. weitz@seas.harvard.edu.
authors.forename: Qiushui
authors.initials: Q
authors.lastname: Chen
authors.affiliation: John A. Paulson School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02139, USA. weitz@seas.harvard.edu.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Utech
authors.affiliation: John A. Paulson School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02139, USA. weitz@seas.harvard.edu.
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.affiliation: Faculty of Chemistry, University of Belgrade, Studentskitrg 12, Belgrade, Serbia.
authors.forename: Radivoje
authors.initials: R
authors.lastname: Prodanovic
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, PR China. jmlin@tsinghua.edu.cn.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Lin
authors.affiliation: John A. Paulson School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02139, USA. weitz@seas.harvard.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Weitz
mesh_terms: D000818:Animals; D056945:Hep G2 Cells; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D051379:Mice; D044085:Microfluidics / Q000379:methods*; D041681:NIH 3T3 Cells; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D020100:Hydrogels; D014867:Water