title: Endothelial dysfunction biomarker, endothelial cell-specific molecule-1, and pediatric metabolic syndrome.
abstract: BACKGROUND
  The aim of this study was to compare serum endothelial cell-specific molecule-1 (endocan) in pediatric patients with metabolic syndrome (MetS) and in healthy children, and to determine whether it can be used as an indicator of endothelium damage-induced complications in pediatric MetS patients.
  
  
  METHODS
  The study included 30 patients, aged 6-16 years, who were diagnosed with MetS. Another 30 children with no diseases were recruited as healthy controls. Endocan concentration was measured using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Endocan was increased almost threefold in the MetS group compared with the healthy group. Systolic arterial tension and diastolic arterial tension, serum triglyceride, total cholesterol, and low-density lipoprotein cholesterol were higher, and high-density lipoprotein cholesterol was lower, in the MetS children than in the healthy group. Fasting blood glucose (FBG), hemoglobin A1c (HBA1C), and homeostasis model assessment insulin resistance (HOMA-IR) were also significantly increased in the children with MetS compared with the healthy group.
  
  
  CONCLUSIONS
  Serum endocan level in pediatric MetS patients could be an important indicator of cardiovascular risk in adulthood.
authors.affiliation: Department of Pediatric Nursing, Faculty of Health Science, Ataturk University, Erzurum, Turkey.
authors.forename: Iclal
authors.initials: I
authors.lastname: Halici
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey.
authors.forename: Saziye Sezin
authors.initials: SS
authors.lastname: Palabiyik
authors.affiliation: Department of Pediatric Nursing, Faculty of Health Science, Ataturk University, Erzurum, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Guducu-Tufekci
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Ozbek-Bilgin
authors.affiliation: Department of Pediatric Endocrinology, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Cayir
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000503:physiopathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*; D012189:Retrospective Studies; D014664:Vasodilation / Q000502:physiology*
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: endocan; endothelial dysfunction; enzyme-linked immunosorbent assay; metabolic syndrome; pediatric