title: Elevated serum levels of MMP-11 correlate with poor prognosis in colon cancer patients.
abstract: BACKGROUND
  Matrix metalloproteinase 11 (MMP11) has been shown to play a key role in human tumor progression and indicates poor clinical outcome in cancer patients.
  
  
  OBJECTIVE
  The current study aimed to evaluate the relationship between serum levels of MMP-11 and prognosis in colon cancer patients.
  
  
  METHODS
  Serum levels of MMP-11 were determined in 92 colon cancer patients and 92 healthy individuals using an enzyme-linked immunosorbent assay (ELISA). Associations between serum MMP-11 levels and clinicopathological characteristics of the patients and their outcomes were investigated. Survival analyses were performed to measure the 5-year overall survival (OS) and disease-free survival (DFS).
  
  
  RESULTS
  Serum MMP-11 levels were substantially higher in colon cancer patients than in healthy controls. Moreover, serum MMP-11 levels were significantly higher in patients with advanced T status, lymph node metastasis, distant metastasis, and a higher TNM stage. Elevated serum levels of MMP-11 were identified as an independent prognostic factor for 5-year mortality and adverse events associated with colon cancer. Multivariate Cox regression analysis identified the serum MMP-11 level as an independent predictor of OS and DFS.
  
  
  CONCLUSIONS
  Our study established that high serum levels of MMP-11 are associated with poor clinical outcome and may serve as a prognostic biomarker in colon cancer patients.
authors.affiliation: Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Li
authors.initials: L
authors.lastname: Pang
authors.affiliation: Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Wang
authors.affiliation: Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Da-Hai
authors.initials: DH
authors.lastname: Xu
authors.affiliation: Department of Gastrointestinal Medicine, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Xiang-Wei
authors.initials: XW
authors.lastname: Meng
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D053507:Matrix Metalloproteinase 11 / Q000097:blood*; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; C511771:MMP11 protein, human; D053507:Matrix Metalloproteinase 11
keywords: Matrix metalloproteinase 11; biomarker; colon cancer; prognosis