title: Novel anticoagulants - an update on the latest developments and management for clinicians treating patients on these drugs.
abstract: There are several novel anticoagulant agents that are being increasingly used as an alternative to warfarin, with these drugs being reported to be at least as effective if not better. Their increased use means that oral care clinicians should have a sound understanding of the mechanism of action, pharmacology, reversal strategies and management of bleeding in patients taking these drugs. Surprisingly, there is little published in the current literature specific to professionals involved in oral health care. In this review, we provide an overview of these drugs and discuss the management of patients who need an oral procedure based on currently available literature and clinical trials.
authors.affiliation: Department of Gastroenterology, Torbay Hospital, Torquay, UK.
authors.forename: Ben
authors.initials: B
authors.lastname: Green
authors.affiliation: Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Rui Amaral
authors.initials: RA
authors.lastname: Mendes
authors.affiliation: Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.
authors.forename: Ruben
authors.initials: R
authors.lastname: Van der Valk
authors.affiliation: Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brennan
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000145:classification; D000991:Antithrombins; D006470:Hemorrhage / Q000188:drug therapy; D006801:Humans; D009909:Oral Health
chemical_list: D000925:Anticoagulants; D000991:Antithrombins
keywords: anticoagulant; apixaban; dabigatran; factor Xa; rivaroxaban; thrombin inhibitor