title: High serum adiponectin levels predict incident falls among middle-aged and older adults: a prospective cohort study.
abstract: adiponectin is an adipocyte-derived hormone with anti-obesity and anti-diabetic properties. However, higher circulating adiponectin levels are related to poor muscle function and physical disability, which suggests a potential link between adiponectin and risk of falls. Nevertheless, no direct association between circulating adiponectin levels and incident fall risk has been reported. Therefore, this study aimed to investigate the relationship between serum adiponectin levels and incident falls in a population of middle-aged and older adults.
  
  
  
  a prospective cohort study.
  
  
  
  Oroshisho Center in Sendai City, Japan.
  
  
  
  Japanese adults who were ≥45 years old (n = 430).
  
  
  
  serum adiponectin levels were measured at baseline, and the subjects were divided into sex-specific tertiles. Data regarding a history of falls were collected via participant recall using a self-reported questionnaire. Incident falls were defined as falls that were experienced by people without a history of falls at baseline.
  
  
  
  during the 2-year follow-up, 15.6% (67/430) of the subjects experienced an incident fall. In the univariate logistic regression analysis, incident falls were significantly more frequent across the increasing sex-specific serum adiponectin tertiles (P for trend = 0.008). Adjusted odds ratios (95% confidence interval) for incident falls were 2.31 (1.07-4.98) in the middle tertile and 3.61 (1.63-7.99) in the highest tertile; this risk was significantly higher than that for the lowest adiponectin tertile (P for trend = 0.002).
  
  
  
  the findings of this prospective cohort study indicate that higher serum adiponectin levels may be a predictor of incident falls.
authors.affiliation: Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
authors.forename: Cong
authors.initials: C
authors.lastname: Huang
authors.affiliation: Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Momma
authors.affiliation: Department of Epidemiology, School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: Kaijun
authors.initials: K
authors.lastname: Niu
authors.affiliation: Department of Medicine and Science in Sports and Exercise, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Chujo
authors.affiliation: Department of Medicine and Science in Sports and Exercise, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Otomo
authors.affiliation: Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Nagatomi
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data*; D052242:Adiponectin / Q000097:blood*; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006801:Humans; D015994:Incidence; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D017678:Sex Distribution; D013997:Time Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers
keywords: adiponectin; biomarker; fall risk; geriatrics; prevention