title: The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness.
abstract: Glucocorticoids (GCs) are involved in a large number of the physiological changes associated with metabolic syndrome and certain psychiatric illness. Although significance is often given to the concentration of GC, its biological action is determined by the activation of intracellular GC receptors (GR). Genetic polymorphisms of the GR and the large array of GR related cofactors can directly or indirectly affect the pathophysiology and evolution of these conditions. This review will discuss the effects of GR mutations on metabolic syndrome and psychotic depression.
authors.affiliation: Corcept Therapeutics, 149 Commonwealth, Menlo Park, CA, United States. Electronic address: Amoraitis@corcept.com.
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Moraitis
authors.affiliation: Corcept Therapeutics, 149 Commonwealth, Menlo Park, CA, United States; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States.
authors.forename: Thaddeus
authors.initials: T
authors.lastname: Block
authors.affiliation: Corcept Therapeutics, 149 Commonwealth, Menlo Park, CA, United States.
authors.forename: Dat
authors.initials: D
authors.lastname: Nguyen
authors.affiliation: Corcept Therapeutics, 149 Commonwealth, Menlo Park, CA, United States; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States.
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Belanoff
mesh_terms: D001692:Biological Transport; D003866:Depressive Disorder / Q000235:genetics; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000235:genetics; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid
keywords: Glucocorticoid receptor; Metabolic syndrome; Polymorphism; Psychiatric disorders