title: Urachal Adenocarcinoma in a Dog.
abstract: An 8-year-old neutered female Labrador retriever was presented with a 3-year history of intermittent haematuria. Ultrasonographic evaluation of the urinary bladder revealed a 2 × 3 × 0.5 cm intraluminal mass arising at the dome. The mass was excised via partial cystectomy. Histopathological examination revealed neoplastic epithelial cells arranged in sheets, irregularly-branching tubules and acini within a fibrovascular stroma. Neoplastic cells were cuboidal to polygonal with abundant foamy amphophilic cytoplasm, typically with a single, large, clear intracytoplasmic vacuole and eccentric nucleus ('signet ring' cells). Neoplastic tubules were often ectatic and contained abundant mucin. Immunohistochemically, the neoplastic cells had weak, cytoplasmic immunoreactivity for cytokeratin 7 and rare, but strong, nuclear immunoreactivity for CDX2. Based on the cellular morphology, immunolabelling characteristics and anatomical location, a diagnosis of adenocarcinoma of urachal origin was made. To the authors' knowledge, this is the first reported case of urachal adenocarcinoma in a dog.
authors.affiliation: Department of Pathobiology, Auburn University College of Veterinary Medicine, Auburn, USA. Electronic address: sms0059@auburn.edu.
authors.forename: S
authors.initials: S
authors.lastname: Shrader
authors.affiliation: 528 Seminole Place, Montgomery, USA.
authors.forename: J
authors.initials: J
authors.lastname: Lauridson
authors.affiliation: Taylor Crossing Animal Hospital, 6897 Atlanta Hwy, Montgomery, AL, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: King
authors.affiliation: Taylor Crossing Animal Hospital, 6897 Atlanta Hwy, Montgomery, AL, USA.
authors.forename: J
authors.initials: J
authors.lastname: Loch
mesh_terms: D000230:Adenocarcinoma / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D001749:Urinary Bladder Neoplasms / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor
keywords: dog; urachal adenocarcinoma; urachal remnant; urachus