title: Adjuvant Intrahepatic Injection Iodine-131-Lipiodol Improves Prognosis of Patients with Hepatocellular Carcinoma After Resection: a Meta-Analysis.
abstract: High incidence of intrahepatic recurrence is a major surgical limitation following hepatectomy of hepatocellular carcinoma (HCC). This study was intended to investigate the effects of adjuvant intrahepatic injection of iodine-131-lipiodol on disease recurrence and survival in patients with HCC who underwent resection. A computerized literature search was performed to identify relevant articles. Data synthesis was performed using Review Manager 5.0 software, and results are presented as odds ratio (OR) with 95 % confidence intervals. Two randomized controlled trials and three case-control studies with a total of 334 participants were analyzed. Iodine-131-lipiodol treatment achieved significantly lower rates of intrahepatic recurrence (OR = 0.48, 95 % confidence interval (95 % CI) = 0.30-0.74; P = 0.001) and early recurrence (<2 year) (OR = 0.45, 95 % CI = 0.23-0.89; P = 0.02). Likewise, iodine-131-lipiodol treatment improved both the 5-year disease-free survival and overall survival significantly (OR = 1.85, 95 % CI = 1.13-3.03; P = 0.01; OR = 2.00, 95 % CI = 0.99-4.04; P = 0.05, respectively). Adjuvant intrahepatic injection of iodine-131-lipiodol resulted in a preventive effect on recurrence and improved survival after resection of HCC. Further larger, multi-centred, randomized prospective trial is warranted.
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361003 China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361003 China.
authors.forename: Lu-Peng
authors.initials: LP
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361003 China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361003 China.
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Zhou
keywords: Hepatocellular carcinoma; Iodine-131-lipiodol; Prognosis; Recurrence