title: Short-term effects of air pollution, markers of endothelial activation, and coagulation to predict major adverse cardiovascular events in patients with acute coronary syndrome: insights from AIRACOS study.
abstract: The aim of this study was to determine whether markers of inflammation and coagulation are associated with short-term particulate matter exposure and predict major adverse cardiovascular events at 360 d in patients with acute coronary syndrome (ACS). We included 307 consecutive patients, and assessed the average concentrations of data on atmospheric pollution in ambient air and meteorological variables from 1 d up to 7 d prior to admission. In patients with ACS, the markers of endothelial activation and coagulation, but not black carbon exposure, are associated with major adverse cardiovascular events at one-year follow-up.
authors.affiliation: a Servicio de Cardiología , Hospital Universitario de Canarias , Santa Cruz de Tenerife , Spain.|b Facultad de Ciencias de la Salud , Universidad Europea de Canarias , Santa Cruz de Tenerife , Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Dominguez-Rodriguez
authors.affiliation: c Departamento de Ciencias Medicas Básicas (Unidad de Fisiología) , Universidad de La Laguna , Santa Cruz de Tenerife , Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Abreu-Gonzalez
authors.affiliation: d Centro de Investigación Atmosférica de Izaña (CIAI) , AEMET, Unidad Asociada al CSIC , Santa Cruz de Tenerife , Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rodríguez
authors.affiliation: e Hospital Universitario Central de Asturias, Área del Corazón , Oviedo , Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Avanzas
authors.affiliation: a Servicio de Cardiología , Hospital Universitario de Canarias , Santa Cruz de Tenerife , Spain.
authors.forename: Ruben A
authors.initials: RA
authors.lastname: Juarez-Prera
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications*; D000368:Aged; D000397:Air Pollution / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001777:Blood Coagulation; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D052638:Particulate Matter / Q000494:pharmacology; D011237:Predictive Value of Tests; D011379:Prognosis; D013030:Spain; D013997:Time Factors
chemical_list: D015415:Biomarkers; D052638:Particulate Matter
keywords: Acute coronary syndrome; air pollution; coagulation; inflammation; prognosis