title: The association between CYP46A1 rs4900442 polymorphism and the risk of Alzheimer's disease: A meta-analysis.
abstract: Polymorphisms in the CYP46A1 rs4900442 have been controversially associated with increased risk of developing Alzheimer's disease (AD). Therefore, a meta-analysis was performed to assess the possible association between CYP46A1 gene rs4900442 polymorphism and AD. A comprehensive search was conducted to identify all case-control or cohort design studies of the associations between CYP46A1 rs4900442 and AD. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed-effects models. Heterogeneity among studies was evaluated using the I(2) and funnel plot and Egger's test were used to evaluate publication bias. Sensitivity analysis was also performed. Six case-control studies corresponded to the inclusion criteria including 1555 AD cases and 1347 controls for the present meta-analysis. Our results showed that no significant associations between CYP46A1 rs4900442 genetic polymorphism and risk of AD in allele model T vs. C (OR=0.947, 95%CI=0.853-1.051), dominant model CC+TC vs. TT (OR=0.878, 95%CI=0.734-1.049) and recessive model CC vs. TC+TT (OR=0.974, 95%CI=0.826-1.149). Moreover, in the subgroup analysis based on location (Chinese and Caucasian), there was significant association in Chinese population in allele model T vs. C (OR=0.780, 95%CI=0.628-0.968), although no obvious associations were found in Caucasian. The meta-analysis suggested that CYP46A1 rs4900442 genetic polymorphism was associated with increased risk of AD in the Chinese population, but no evidences were detected in Caucasian population.
authors.affiliation: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.
authors.forename: Fengjv
authors.initials: F
authors.lastname: Jia
authors.affiliation: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Song
authors.affiliation: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, China.
authors.forename: Xixun
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, China. Electronic address: jhkyk@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D000072556:Cholesterol 24-Hydroxylase / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: D000072556:Cholesterol 24-Hydroxylase
keywords: Alzheimer’s disease; CYP46A1; Meta-analysis; rs4900442