title: The Regulation of NF-κB Subunits by Phosphorylation.
abstract: The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-κB in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-κB activation. However, significant research efforts have revealed the crucial contribution of NF-κB phosphorylation to controlling NF-κB directed transactivation. Importantly, NF-κB phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-κB for therapeutic benefit. This review will focus on the phosphorylation of the NF-κB subunits and the impact on NF-κB function.
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. frank.christian@glasgow.ac.uk.
authors.forename: Frank
authors.initials: F
authors.lastname: Christian
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. e.smith.4@research.gla.ac.uk.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Smith
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. Ruaidhri.Carmody@glasgow.ac.uk.
authors.forename: Ruaidhrí J
authors.initials: RJ
authors.lastname: Carmody
keywords: NF-κB; kinase; phosphorylation; transcription factor