title: Optically Monitoring Mineralization and Demineralization on Photoluminescent Bioactive Nanofibers.
abstract: Bone regeneration and scaffold degradation do not usually follow the same rate, representing a daunting challenge in bone repair. Toward this end, we propose to use an external field such as light (in particular, a tissue-penetrating near-infrared light) to precisely monitor the degradation of the mineralized scaffold (demineralization) and the formation of apatite mineral (mineralization). Herein, CaTiO3:Yb(3+),Er(3+)@bioactive glass (CaTiO3:Yb(3+),Er(3+)@BG) nanofibers with upconversion (UC) photoluminescence (PL) were synthesized. Such nanofibers are biocompatible and can emit green and red light under 980 nm excitation. The UC PL intensity is quenched during the bone-like apatite formation on the surface of the nanofibers in simulated body fluid; more mineral formation on the nanofibers induces more rapid optical quenching of the UC PL. Furthermore, the quenched UC PL can recover back to its original magnitude when the apatite on the nanofibers is degraded. Our work suggests that it is possible to optically monitor the apatite mineralization and demineralization on the surface of nanofibers used in bone repair.
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Clinical Research Institute, Zhejiang Provincial People's Hospital , Hangzhou 310014, P.R. China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Prosthetic Dentistry, Second Affiliated Hospital, College of Medicine, Zhejiang University , Hangzhou 310009, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Gaorong
authors.initials: G
authors.lastname: Han
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.|Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma , 101 Stephenson Parkway, Norman, Oklahoma 73019-5300, United States.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000528:radiation effects* / Q000633:toxicity; D040761:Biomimetic Materials; D017610:Calcium Compounds / Q000138:chemical synthesis / Q000528:radiation effects / Q000633:toxicity; D002478:Cells, Cultured; D004871:Erbium / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity; D049449:Luminescence; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D057139:Nanofibers / Q000737:chemistry / Q000528:radiation effects* / Q000633:toxicity; D010087:Oxides / Q000138:chemical synthesis / Q000528:radiation effects / Q000633:toxicity; D014025:Titanium / Q000528:radiation effects / Q000633:toxicity; D015018:Ytterbium / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D010087:Oxides; C059910:perovskite; D004871:Erbium; D014025:Titanium; D015018:Ytterbium