title: Serous tubal intraepithelial carcinoma, chronic fallopian tube injury, and serous carcinoma development.
abstract: Ovarian carcinoma is the deadliest gynecological malignancy. Previous studies have suggested that the fallopian tube may be the primary site for high-grade serous carcinoma. In prophylactic salpingo-oophorectomies from women with hereditary high risk for ovarian cancer, precursors can be assessed prior to onset and studied as a model for serous cancer precursor lesions. Epidemiologic studies indicate that carcinogenesis may be a result of chronic fallopian tube injury. The aims of this study were to (1) to examine the incidence of serous tubal intraepithelial carcinoma (STIC) in relation to other clinical parameters and (2) to evaluate whether chronic fallopian tube injury was related to cancer development. This study enrolled 101 women, comprising the following three groups: hereditary (n = 60), sporadic serous cancer (n = 18; endometrial cancers were excluded), and control (n = 23). The cases were histologically examined and clinical risk factors were collected. The histological changes were compared between different patients and correlated to clinical risk factors. STICs were identified primarily on the fallopian tube fimbria. The incidence of STIC was 3 % in the hereditary patients. In sporadic serous cancer cases, 61 % were associated with STIC and tubal carcinoma (p < 0.001). No differences in tubal injury or inflammation were seen when comparing the sporadic serous cancer group and the control group or within the hereditary group. STIC and invasive cancer were seen more often in the older patients than in the younger patients (p = 0.528). This small study, no correlation with chronic tubal injury or inflammation was identified.
authors.affiliation: Department of Oncology-Pathology, Karolinska Institutet and Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Malmberg
authors.affiliation: Department of Women's and Children's Health, Karolinska Institutet, and Department of Gynecology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Charlotta
authors.initials: C
authors.lastname: Klynning
authors.affiliation: Department of Women's and Children's Health, Karolinska Institutet, and Department of Gynecology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Angelique
authors.initials: A
authors.lastname: Flöter-Rådestad
authors.affiliation: Department of Oncology-Pathology, Karolinska Institutet and Department of Pathology, Karolinska University Hospital, Stockholm, Sweden. joseph.carlson@ki.se.|Department of Pathology and Cytology, Karolinska University Hospital, 17176, Stockholm, Sweden. joseph.carlson@ki.se.
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Carlson
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000473:pathology; D002908:Chronic Disease; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis / Q000473:pathology*; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005187:Fallopian Tubes / Q000293:injuries / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*
keywords: Carcinoma in situ; Fallopian tubes; Inflammation; Ovary; Serous cystadenocarcinoma