title: [Procedure for daylight methyl aminolevulinate photodynamic therapy to treat actinic keratoses].
abstract: Actinic keratosis (AK), also known as solar keratosis or pre-cancerous keratosis, is frequently observed in areas of skin exposed to sunlight, particularly in light-skinned patients. In France, photodynamic therapy using red light (conventional PDT) and methylamino 5-levulinate (MAL) is indicated in the treatment of thin or non-hyperkeratotic and non-pigmented multiple AK lesions or large zones covered with AK lesions. It is well-known for its efficacy but also for its side effects, especially pain during illumination, which can limit its use. An alternative to PDT using natural daylight has recently been proposed to treat actinic keratosis lesions, and results in greater flexibility as well as significant reduction in pain. The lesions are prepared as for conventional PDT, with MAL cream being applied by the physician or the patient, after which they are exposed to natural daylight for 2hours. The lesions are then gently cleansed and protected from natural light for 24hours. This paper seeks to provide a precise description of the daylight PDT procedure for the treatment of AK.
authors.affiliation: Service de dermatologie, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France.
authors.forename: C
authors.initials: C
authors.lastname: Girard
authors.affiliation: Service de dermatologie, CHU Pontchaillou Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors.forename: H
authors.initials: H
authors.lastname: Adamski
authors.affiliation: Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Basset-Séguin
authors.affiliation: Cabinet de dermatologie, 28, rue Seré-Depoin, 95300 Pontoise, France.
authors.forename: P
authors.initials: P
authors.lastname: Beaulieu
authors.affiliation: Service de dermatologie, CHU de Nantes, place Alexis-Ricordeau, 44093 Nantes cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Dreno
authors.affiliation: Cabinet de dermatologie, 9, rue du 29-Juillet, 62000 Arras, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Riboulet
authors.affiliation: Service de dermatologie, CHU de Nice, hôpital l'Archet 2, 151, route Saint-Antoine-de-Ginestière, CS 23079, 06202 Nice, France. Electronic address: lacour@unice.fr.
authors.forename: J-P
authors.initials: JP
authors.lastname: Lacour
mesh_terms: D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002985:Clinical Protocols; D005148:Facial Dermatoses / Q000188:drug therapy; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy*; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D010353:Patient Education as Topic; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012536:Scalp Dermatoses / Q000188:drug therapy; D063465:Skin Cream; D013472:Sunlight; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid
keywords: Actinic keratosis; Aminolévulinate de méthyle; Daylight; Kératoses actiniques; Lumière du jour; Methyl aminolevulinate; Photodynamic therapy; Photothérapie dynamique topique