title: Biodistribution and Radiation Dosimetry of the Enterobacteriaceae-Specific Imaging Probe [(18)F]Fluorodeoxysorbitol Determined by PET/CT in Healthy Human Volunteers.
abstract: [(18)F]fluorodeoxysorbitol ([(18)F]FDS) is the first radiopharmaceutical specific for a category of bacteria and has the potential to specifically detect Enterobacteriaceae infections. The purpose of this study was to testify the safety and investigate the biodistribution and radiation dosimetry of [(18)F]FDS in healthy human bodies.
  
  
  
  Six healthy subjects were intravenously injected with 320-520 MBq [(18)F]FDS. On each subject, 21 whole-body emission scans and a brain scan were conducted at settled time points within the next 4 h. Residence time for each source organ was determined by multi-exponential regression. Absorbed doses for target organs and effective dose were calculated via OLINDA/EXM.
  
  
  
  No adverse events due to [(18)F]FDS injection were observed in the study. The tracer was cleared rapidly from the blood pool through the urinary system. A small portion was cleared into the gut through the hepatobiliary system. The effective dose (ED) was estimated to be 0.021 ± 0.001 mSv/MBq. The organ receiving the highest absorbed dose was the urinary bladder wall (0.25 ± 0.03 mSv/MBq).
  
  
  
  [(18)F]FDS is safe and well tolerated. The effective dose was comparable to that of other F-18 labeled radiotracers. [(18)F]FDS is suitable for human use from a radiation dosimetry perspective.
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Wenjia
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Yao
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Haiqun
authors.initials: H
authors.lastname: Xing
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Washington University in St Louis, St Louis, MI, USA.
authors.forename: Yuan-Chuan
authors.initials: YC
authors.lastname: Tai
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Yanru
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, Dalian University of technology, Dalian, China.
authors.forename: Hongkai
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors.forename: Zibo
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors.forename: Zhanhong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, China. Huoli@pumch.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Huo
mesh_terms: D000328:Adult; D004755:Enterobacteriaceae / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015335:Molecular Probes / Q000737:chemistry*; D009928:Organ Specificity / Q000528:radiation effects; D000072078:Positron Emission Tomography Computed Tomography; D011874:Radiometry; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000737:chemistry; D014018:Tissue Distribution / Q000528:radiation effects; D051598:Whole Body Imaging
chemical_list: C531573:2-deoxy-2-fluorosorbitol; D005462:Fluorine Radioisotopes; D015335:Molecular Probes; D013012:Sorbitol
keywords: Biodistribution; Enterobacteriaceae; PET; Radiation dosimetry; [18F] FDS