title: [Cerebriform variant type of T cell prolymphocytic leukemia: Report of one case].
abstract: T cell Prolymphocytic Leukemia (T-PLL) is a rare and aggressive mature T cell Lymphocyte Leukemia. Twenty five percent of cases present as a small cell variant, and only 5% as a cerebriform variant. We report a 58 year-old man with rapidly progressive severe leukocytosis, skin lesions, lymphadenopathy, hepatosplenomegaly and pleural effusion. The lymphocytes had a cerebriform type. The diagnosis of T-PLL variant was made by morphology and immunophenotype study of peripheral blood. Karyotype was found to be complex. He was refractory to chemotherapy and died two months later.
authors.forename: Camila
authors.initials: C
authors.lastname: Peña
authors.forename: Ximena
authors.initials: X
authors.lastname: Valladares
authors.forename: Carolina
authors.initials: C
authors.lastname: Soto
authors.forename: Andrea
authors.initials: A
authors.lastname: Encina
authors.forename: Neda
authors.initials: N
authors.lastname: Marinov
authors.forename: María Soledad
authors.initials: MS
authors.lastname: Undurraga
authors.forename: María Elena
authors.initials: ME
authors.lastname: Cabrera
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping; D015461:Leukemia, Prolymphocytic, T-Cell / Q000097:blood / Q000235:genetics / Q000473:pathology*; D007964:Leukocytosis; D008297:Male; D008875:Middle Aged