title: Postoperative AMH reduction is not associated with reduced fecundity two years following ovarian cyst surgery.
abstract: In a prospective study, we investigated the impact of anti-Müllerian hormone (AMH) changes following ovarian cyst surgery on the probability to achieve pregnancy and live birth. Women of reproductive age (n = 60) were included before surgery for benign ovarian cysts. Serum AMH concentrations were determined pre- and postoperative at 6 and 24 months. Information regarding pregnancy wish and attempts to conceive were obtained by a questionnaire. At the time of inclusion, 45/60 women reported desire of children. At six months, the levels of AMH decreased significantly in the whole group and further reduction was observed at two years (from 2.7 μg/L to 2.0 μg/L to 1.1 μg/L, respectively, p<  0.008), with a percentage reduction of 42.9%. At two-year follow-up, 36 women reported to have attempted to conceive and 18 achieved pregnancy (50%), with a live birth rate of 33%. The percentage change in AMH at two years did not differ significantly between the women who conceived versus those who did not (p = 0.117). Data reported herein demonstrate that the AMH reduction following ovarian cyst surgery is maintained two years after surgery; however, the postoperative AMH decrease that follows ovarian cyst surgery might not reduce the chances to achieve pregnancy.
authors.affiliation: a Department of Oncology-Pathology , Karolinska Institutet , Stockholm , Sweden.|b Department of Obstetrics and Gynecology , Södersjukhuset , Stockholm , Sweden.
authors.forename: Tekla
authors.initials: T
authors.lastname: Lind
authors.affiliation: c Department of Neurobiology , Care Sciences and Society, Karolinska Institutet , Stockholm , Sweden.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lampic
authors.affiliation: d Division of Obstetrics/Gynecology, Department of Clinical Science , Intervention and Technology, Karolinska Institutet , Stockholm , Sweden , and.|e Division of Reproductive Medicine, Department of Obstetrics and Gynecology , Karolinska University , Stockholm , Sweden.
authors.forename: Jan I
authors.initials: JI
authors.lastname: Olofsson
authors.affiliation: a Department of Oncology-Pathology , Karolinska Institutet , Stockholm , Sweden.|e Division of Reproductive Medicine, Department of Obstetrics and Gynecology , Karolinska University , Stockholm , Sweden.
authors.forename: Kenny A
authors.initials: KA
authors.lastname: Rodriguez-Wallberg
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005298:Fertility; D006801:Humans; D050498:Live Birth; D010048:Ovarian Cysts / Q000601:surgery*; D011184:Postoperative Period; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone
keywords: (5-7) AMH; cyst enucleation; live birth rate; ovarian cyst surgery; ovarian reserve; pregnancy outcome