title: Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis.
abstract: OBJECTIVE
  The objective of this meta-analysis is to determine whether there is a higher incidence of preeclampsia (PE) in pregnancies achieved by oocyte donation (OD) compared with pregnancies achieved by in vitro fertilization with autologous oocytes (IVF).
  
  
  METHODS
  A systematic review was performed to identify relevant studies published from January 1994 until April 2015 with at least an abstract in English using PubMed, ISI Web of Knowledge, and clinicaltrials.gov. The 11 studies included in this systematic review were retrospective and prospective cohort studies of women reporting results on the association between oocyte donation vs. in vitro fertilization (exposure) and preeclampsia (outcome).
  
  
  RESULTS
  Oocyte donation is a risk factor for the development of PE compared to IVF cycles, with a weighted OR of 3.12 under a fixed effects method (FEM: no heterogeneity between the studies). The weighted OR under a random effects model was 2.9 (REM: heterogeneity between the studies). The meta-regression analysis showed that neither multiple pregnancies (estimate = 0.08; p = 0.19) nor patient age (estimate = -2.29; p = 0.13) significantly explained the variability of the effect of oocyte donation on PE. Q statistic was 12.78 (p = 0.237), suggesting absence of heterogeneity between the studies.
  
  
  CONCLUSIONS
  Pregnancies achieved by oocyte donation confer a threefold increase in the likelihood of developing PE than those achieved by in vitro fertilization with own oocytes. Physicians should be aware of this risk in order to both counsel patients and monitor pregnancies accordingly.
authors.affiliation: Clínica EUGIN, Travessera de les Corts 322, Barcelona, 08029, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Blázquez
authors.affiliation: Fundació Privada EUGIN, Barcelona, 08029, Spain.
authors.forename: Désirée
authors.initials: D
authors.lastname: García
authors.affiliation: Clínica EUGIN, Travessera de les Corts 322, Barcelona, 08029, Spain.
authors.forename: Amelia
authors.initials: A
authors.lastname: Rodríguez
authors.affiliation: Clínica EUGIN, Travessera de les Corts 322, Barcelona, 08029, Spain. rvassena@eugin.es.
authors.forename: Rita
authors.initials: R
authors.lastname: Vassena
authors.affiliation: BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Figueras
authors.affiliation: Clínica EUGIN, Travessera de les Corts 322, Barcelona, 08029, Spain.|Fundació Privada EUGIN, Barcelona, 08029, Spain.
authors.forename: Valérie
authors.initials: V
authors.lastname: Vernaeve
mesh_terms: D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D018587:Oocyte Donation / Q000009:adverse effects*; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors
keywords: In vitro fertilization; Induced hypertension; Oocyte donation; Preeclampsia; Pregnancy