title: Working memory filtering continues to develop into late adolescence.
abstract: While most measures of working memory (WM) performance have been shown to plateau by mid-adolescence and developmental changes in fronto-parietal regions supporting WM encoding and maintenance have been well characterized, little is known about developmental variation in WM filtering. We investigated the possibility that the neural underpinnings of filtering in WM reach maturity later in life than WM function without filtering. Using a cued WM filtering task (McNab and Klingberg, 2008), we investigated neural activity during WM filtering in a sample of 64 adults and adolescents. Regardless of age, increases in WM activity with load were concentrated in the expected fronto-parietal network. For adults, but not adolescents, recruitment of the basal ganglia during presentation of a filtering cue was associated with neural and behavioral indices of successful filtering, suggesting that WM filtering and related basal ganglia function may still be maturing throughout adolescence and into adulthood.
authors.affiliation: Department of Psychology, University of Washington, Seattle, WA, United States.
authors.forename: Matthew
authors.initials: M
authors.lastname: Peverill
authors.affiliation: Department of Psychology, University of Washington, Seattle, WA, United States.
authors.forename: Katie A
authors.initials: KA
authors.lastname: McLaughlin
authors.affiliation: Department of Psychology, University of Toronto, Toronto, ON, Canada.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Finn
authors.affiliation: Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States. Electronic address: sheridan.margaret@unc.edu.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Sheridan
mesh_terms: D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology*; D000328:Adult; D000375:Aging / Q000502:physiology / Q000523:psychology; D001479:Basal Ganglia / Q000502:physiology; D001931:Brain Mapping; D003463:Cues; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology
keywords: Adolescence; Basal ganglia; Working memory; Working memory filtering