title: The use of stable isotope-labeled drug as microtracers with conventional LC-MS/MS to support human absolute bioavailability studies: are we there yet?
authors.affiliation: Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Drug Metabolism & Pharmacokinetics, Millennium Pharmaceuticals, Inc., A Wholly Owned Subsidiary of Takeda Pharmaceutical Company Limited, 40 Landsdowne Street, Cambridge, MA 02139, USA.
authors.forename: Swapan K
authors.initials: SK
authors.lastname: Chowdhury
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D001569:Benzodiazepines / Q000032:analysis / Q000493:pharmacokinetics; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007553:Isotope Labeling; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000378:metabolism; D010880:Piperidines; D011720:Pyrazoles / Q000032:analysis / Q000493:pharmacokinetics; D011743:Pyrimidines / Q000032:analysis / Q000493:pharmacokinetics; D053719:Tandem Mass Spectrometry
chemical_list: D004364:Pharmaceutical Preparations; D010880:Piperidines; D011720:Pyrazoles; D011743:Pyrimidines; D001569:Benzodiazepines; C551803:ibrutinib; C568301:evacetrapib; D000225:Adenine
keywords: AMS; LC–MS/MS; absolute bioavailability; microtracer; stable isotope label