title: Regulation of mitochondrial calcium in plants versus animals.
abstract: Ca(2+) acts as an important cellular second messenger in eukaryotes. In both plants and animals, a wide variety of environmental and developmental stimuli trigger Ca(2+) transients of a specific signature that can modulate gene expression and metabolism. In animals, mitochondrial energy metabolism has long been considered a hotspot of Ca(2+) regulation, with a range of pathophysiology linked to altered Ca(2+) control. Recently, several molecular players involved in mitochondrial Ca(2+) signalling have been identified, including those of the mitochondrial Ca(2+) uniporter. Despite strong evidence for sophisticated Ca(2+) regulation in plant mitochondria, the picture has remained much less clear. This is currently changing aided by live imaging and genetic approaches which allow dissection of subcellular Ca(2+) dynamics and identification of the proteins involved. We provide an update on our current understanding in the regulation of mitochondrial Ca(2+) and signalling by comparing work in plants and animals. The significance of mitochondrial Ca(2+) control is discussed in the light of the specific metabolic and energetic needs of plant and animal cells.
authors.affiliation: Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation (INRES), University of Bonn, Friedrich-Ebert-Allee 144, D-53113 Bonn, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Wagner
authors.affiliation: Department of Biology and CNR Institute of Neurosciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: De Bortoli
authors.affiliation: Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation (INRES), University of Bonn, Friedrich-Ebert-Allee 144, D-53113 Bonn, Germany markus.schwarzlander@uni-bonn.de ildi@civ.bio.unipd.it.
authors.forename: Markus
authors.initials: M
authors.lastname: Schwarzländer
authors.affiliation: Department of Biology and CNR Institute of Neurosciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy markus.schwarzlander@uni-bonn.de ildi@civ.bio.unipd.it.
authors.forename: Ildikò
authors.initials: I
authors.lastname: Szabò
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004734:Energy Metabolism; D007448:Invertebrates / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*; D014714:Vertebrates / Q000378:metabolism*
chemical_list: D002118:Calcium
keywords: Bioenergetics; Ca2+; ion channels; ion transporters; mitochondria.