title: Automated eligibility screening and monitoring for genotype-driven precision oncology trials.
abstract: The Information Systems Department at Memorial Sloan Kettering Cancer Center developed the DARWIN Cohort Management System (DCMS). The DCMS identifies and tracks cohorts of patients based on genotypic and clinical data. It assists researchers and treating physicians in enrolling patients to genotype-matched IRB-approved clinical trials. The DCMS sends automated, actionable, and secure email notifications to users with information about eligible or enrolled patients before their upcoming appointments. The system also captures investigators input via annotations on patient eligibility and preferences on future status updates. As of August 2015, the DCMS is tracking 159,893 patients on both clinical operations and research cohorts. 134 research cohorts have been established and track 64,473 patients. 51,192 of these have had one or more genomic tests including MSK-IMPACT, comprising the pool eligible for genotype-matched studies. This paper describes the design and evolution of this Informatics solution.
authors.affiliation: Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY eubankm@mskcc.org.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Eubank
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: David M
authors.initials: DM
authors.lastname: Hyman
authors.affiliation: Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Amritha D
authors.initials: AD
authors.lastname: Kanakamedala
authors.affiliation: Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Gardos
authors.affiliation: Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Wills
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY Division of Health Informatics, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Stetson
mesh_terms: D002173:Cancer Care Facilities; D002986:Clinical Trials as Topic / Q000458:organization & administration*; D000073458:Data Warehousing; D016208:Databases, Factual; D004608:Eligibility Determination; D005838:Genotype; D006801:Humans; D007256:Information Systems; D008495:Medical Oncology; D009519:New York City; D018579:Patient Selection; D057285:Precision Medicine
keywords: clinical research informatics; genomics; individualized medicine; informatics; precision oncology