title: Does Antiarrhythmic Drug During Cardiopulmonary Resuscitation Improve the One-month Survival: The SOS-KANTO 2012 Study.
abstract: BACKGROUND
  Antiarrhythmic drugs (AAD) are often used for fatal ventricular arrhythmias during cardiopulmonary resuscitation (CPR). However, the efficacy of initial AAD administration during CPR in improving long-term prognosis remains unknown. This study retrospectively evaluated the effect of AAD administration during CPR on 1-month prognosis in the SOS-KANTO 2012 study population.
  
  
  RESULTS
  Of the 16,164 out-of-hospital cardiac arrest cases, 1350 shock-refractory patients were included: 747 patients not administered AAD and 603 patients administered AAD. Statistical adjustment for potential selection bias was performed using propensity score matching, yielding 1162 patients of whom 792 patients were matched (396 pairs). The primary outcome was 1-month survival. The secondary outcome was the proportion of patients with favorable neurological outcome at 1 month. Logistic regression with propensity scoring demonstrated an odds ratio (OR) for 1-month survival in the AAD group of 1.92 (P < 0.01), whereas the OR for favorable neurological outcome at 1 month was 1.44 (P = 0.26).
  
  
  CONCLUSIONS
  Significantly greater 1-month survival was observed in the AAD group compared with the non-AAD group. However, the effect of ADD on the likelihood of a favorable neurological outcome remains unclear. The findings of the present study may indicate a requirement for future randomized controlled trials evaluating the effect of ADD administration during CPR on long-term prognosis.
authors.affiliation: *Tokai University School of Medicine, Kanagawa, Japan;†Tokyo Bay Urayasu/Ichikawa Medical Center, Chiba, Japan;‡Saitama Red Cross Hospital, Saitama, Japan;§Nihon University Surugadai Hospital, Tokyo, Japan;¶Nihon University School of Medicine, Tokyo, Japan;‖National Cerebral and Cardiovascular Center Hospital, Osaka, Japan;**National Center of Neurology and Psychiatry, Tokyo, Japan;††Tokyo Women's Medical University Hospital, Tokyo, Japan; and‡‡Yokohama City University Medical Center, Kanagawa, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Amino
authors.forename: Sadaki
authors.initials: S
authors.lastname: Inokuchi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikari
authors.forename: Hiraku
authors.initials: H
authors.lastname: Funakoshi
authors.forename: Katsura
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Masakazu
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakurai
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tahara
authors.forename: Naohiro
authors.initials: N
authors.lastname: Yonemoto
authors.forename: Ken
authors.initials: K
authors.lastname: Nagao
authors.forename: Arino
authors.initials: A
authors.lastname: Yaguchi
authors.forename: Naoto
authors.initials: N
authors.lastname: Morimura
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D016017:Odds Ratio; D058687:Out-of-Hospital Cardiac Arrest / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D057216:Propensity Score; D020127:Recovery of Function; D012189:Retrospective Studies; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000889:Anti-Arrhythmia Agents