title: HOPX: The Unusual Homeodomain-Containing Protein.
abstract: The homeodomain-only protein homeobox (HOPX) is the smallest known member of the homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely expressed in diverse tissues, where it is critically involved in the regulation of proliferation and differentiation. In human skin, HOPX controls epidermal formation through the regulation of late differentiation markers, and HOPX expression correlates with the level of differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a lineage tracing marker of quiescent hair follicle stem cells. This review discusses current knowledge of HOPX structure and function in normal and pathological conditions.
authors.affiliation: Laboratory of Cutaneous Biology, Service of Dermatology and Venereology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
authors.forename: Anita
authors.initials: A
authors.lastname: Mariotto
authors.affiliation: Laboratory of Cutaneous Biology, Service of Dermatology and Venereology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
authors.forename: Olesya
authors.initials: O
authors.lastname: Pavlova
authors.affiliation: Laboratory of Cutaneous Biology, Service of Dermatology and Venereology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Park
authors.affiliation: Laboratory of Cutaneous Biology, Service of Dermatology and Venereology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
authors.forename: Marcel
authors.initials: M
authors.lastname: Huber
authors.affiliation: Laboratory of Cutaneous Biology, Service of Dermatology and Venereology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. Electronic address: daniel.hohl@chuv.ch.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hohl
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D005801:Genes, Homeobox / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D051379:Mice; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000235:genetics* / Q000503:physiopathology; D014407:Tumor Cells, Cultured
chemical_list: D018398:Homeodomain Proteins