title: Chemotherapy-Associated Hepatotoxicities.
abstract: Chemotherapy can cause liver injury, which should be considered when planning for safe surgical hepatic resections. This article reviews the pertinent clinical findings and applications for surgeons to take into account in evaluating patients for hepatic resection with liver injury secondary to chemotherapy. A selection of the pertinent literature discussing types of chemotherapy-associated hepatotoxicities, mechanisms of injury, methods for identification of liver injury, and impact on surgical outcomes is discussed.
authors.affiliation: Complex Surgical Oncology, Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: White
authors.affiliation: Department of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address: yfong@coh.org.
authors.forename: Yuman
authors.initials: Y
authors.lastname: Fong
authors.affiliation: Hepatobiliary and Pancreatic Surgery, Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Singh
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Hepatectomy; Liver injury; Sinusoidal obstruction syndrome; Steatohepatitis; Steatosis