title: Eosinophilic Enteritis in Horses with Motor Neuron Disease.
abstract: BACKGROUND
  Equine motor neuron disease (EMND) is a neuromuscular disorder that affects adult horses. Although EMND has been linked to vitamin E deficiency, its etiopathogenesis is poorly understood.
  
  
  OBJECTIVE
  To describe clinical features, laboratory results, and postmortem findings in a series of young horses with motor neuron disease (MND).
  
  
  METHODS
  A herd of 15 young Andalusian horses with weakness, weight loss, muscle atrophy, and muscle fasciculations related to restricted intake of green forage.
  
  
  METHODS
  A case series is presented in which horses were subjected to a clinical examination and plasma vitamin E measurement. Five severely affected horses were euthanized for detailed postmortem examination. Muscle specimens were taken from the M. sacrocaudalis dorsalis medialis and the M. gluteus medius for histopathologic and morphometric evaluation.
  
  
  RESULTS
  MND was diagnosed in 5 horses based on clinical signs, low serum levels of vitamin E (0.11 ± 0.05 mg/dL; normal range,: 0.3-1.5 mg/dL), changes in muscle histopathology (neurogenic atrophy), and spinal cord lesions (neuronal chromatolysis in ventral horns). An unexpected postmortem finding was the presence of intestinal inflammation (catarrhal enteritis, edema, and eosinophilic infiltrate) associated with the presence of giant ciliated protozoa in all of the horses.
  
  
  CONCLUSIONS
  Although a mechanistic link could not be established, it is hypothesized that intestinal inflammation may have been involved in the decreased absorption of vitamin E, thus favoring the development of MND.
authors.affiliation: Veterinary Teaching Hospital and Department of Animal Medicine and Surgery, University of Cordoba, Cordoba, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Díez de Castro
authors.affiliation: Department of Comparative Anatomy and Pathological Anatomy, Faculty of Veterinary Sciences, University of Cordoba, Cordoba, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Zafra
authors.affiliation: Laboratory of Muscular Biopathology, Department of Comparative Anatomy and Pathological Anatomy, Faculty of Veterinary Sciences, University of Cordoba, Cordoba, Spain.
authors.forename: L M
authors.initials: LM
authors.lastname: Acevedo
authors.affiliation: Department of Comparative Anatomy and Pathological Anatomy, Faculty of Veterinary Sciences, University of Cordoba, Cordoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pérez
authors.affiliation: Department of Animal Health, Parasitology Section, Faculty of Veterinary Sciences, University of Cordoba, Cordoba, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Acosta
authors.affiliation: Laboratory of Muscular Biopathology, Department of Comparative Anatomy and Pathological Anatomy, Faculty of Veterinary Sciences, University of Cordoba, Cordoba, Spain.
authors.forename: J L L
authors.initials: JL
authors.lastname: Rivero
authors.affiliation: Veterinary Teaching Hospital and Department of Animal Medicine and Surgery, University of Cordoba, Cordoba, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Aguilera-Tejero
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D004032:Diet / Q000662:veterinary; D004751:Enteritis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D004802:Eosinophilia / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005756:Gastritis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D006734:Horse Diseases / Q000469:parasitology / Q000473:pathology*; D006736:Horses; D008297:Male; D016472:Motor Neuron Disease / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D009133:Muscular Atrophy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary; D011529:Protozoan Infections, Animal / Q000469:parasitology / Q000473:pathology; D014810:Vitamin E / Q000097:blood
chemical_list: D014810:Vitamin E
keywords: EMND; hematoxylin; intestine; protozoa; vitamin E