title: Functional Connectome before and following Temporal Lobectomy in Mesial Temporal Lobe Epilepsy.
abstract: As mesial temporal lobe epilepsy (mTLE) has been recognized as a network disorder, a longitudinal connectome investigation may shed new light on the understanding of the underlying pathophysiology related to distinct surgical outcomes. Resting-state functional MRI data was acquired from mTLE patients before (n = 37) and after (n = 24) anterior temporal lobectomy. According to surgical outcome, patients were classified as seizure-free (SF, n = 14) or non-seizure-free (NSF, n = 10). First, we found higher network resilience to targeted attack on topologically central nodes in the SF group compared to the NSF group, preoperatively. Next, a two-way mixed analysis of variance with between-subject factor 'outcome' (SF vs. NSF) and within-subject factor 'treatment' (pre-operation vs. post-operation) revealed divergent dynamic reorganization in nodal topological characteristics between groups, in the temporoparietal junction and its connection with the ventral prefrontal cortex. We also correlated the network damage score (caused by surgical resection) with postsurgical brain function, and found that the damage score negatively correlated with postoperative global and local parallel information processing. Taken together, dynamic connectomic architecture provides vital information for selecting surgical candidates and for understanding brain recovery mechanisms following epilepsy surgery.
authors.affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.|Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China.|Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei 230000, China.|Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China.|Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
authors.forename: Gong-Jun
authors.initials: GJ
authors.lastname: Ji
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China.|Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Zhengge
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Kangjian
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Radiology, Taishan Medical University, Tai'an 271016, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiao
authors.affiliation: Institute of Psychiatry, Kings College London, London, United Kingdom.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Richardson
authors.affiliation: Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China.|Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D063132:Connectome; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000601:surgery*; D055815:Young Adult