title: Effect of hyperlipidemia on response to nonsurgical periodontal therapy: Statin users versus nonusers.
abstract: OBJECTIVE
  To evaluate the response to nonsurgical periodontal therapy among hyperlipidemic subjects and whether statin use by hyperlipidemic subjects influences the response.
  
  
  METHODS
  This study was conducted on 107 chronic periodontitis subjects (35 normolipidemic [NL] controls, 36 hyperlipidemics on nonpharmacological therapy and 36 hyperlipidemics on statins). Periodontal (plaque index, gingival index [GI], probing depth [PD], and clinical attachment level [CAL]) and biochemical (plasma triglyceride [TG], total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], and high-DL-C [HDL-C] levels) examination was done at baseline and 3 months after nonsurgical periodontal treatment.
  
  
  RESULTS
  Both the NL and statin groups exhibited significantly greater improvement in GI as compared to the hyperlipidemic group on nonpharmacological therapy (P = 0.004 and 0.006, respectively). Mean change in PD correlated negatively with baseline TC (r = -0.306) and LDL-C (r = -0.360) while mean change in GI positively correlated with baseline HDL-C (r = 0.219). Regression analyses revealed that mean change in PD was negatively associated with LDL-C (β = -0.358, P < 0.001) while mean change in GI was positively associated with HDL-C (β = 0.219, P = 0.023).
  
  
  CONCLUSIONS
  While higher baseline lipid levels were somewhat detrimental to the resolution of inflammation postperiodontal treatment, the inclusion of statin therapy among hyperlipidemic subjects seemed to improve clinical response as compared to those devoid of the drug. The findings of the study are suggestive of a possible adjunctive role of statins in periodontal treatment that warrants future studies.
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Sangwan
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Tewari
authors.affiliation: Department of Medicine, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors.forename: Harpreet
authors.initials: H
authors.lastname: Singh
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Rajinder Kumar
authors.initials: RK
authors.lastname: Sharma
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Satish Chander
authors.initials: SC
authors.lastname: Narula
keywords: Cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitors; hyperlipidemia; nonsurgical periodontal therapy; periodontitis