title: Translational atherosclerosis research: From experimental models to coronary artery disease in humans.
abstract: Atherosclerosis is the leading cause of death worldwide. Research on the pathophysiological mechanisms of atherogenesis has made tremendous progress over the past two decades. However, despite great advances there is still a lack of therapies that reduce adverse cardiovascular events to an acceptable degree. This review addresses successes, but also questions, challenges, and chances regarding the translation of basic science results into clinical practice, i.e. the capability to apply the results of basic and/or clinical research in order to design therapies suitable to improve patient outcome. Specifically, it discusses problems in translating findings from the most broadly used murine models of atherosclerosis into clinically feasible therapies and strategies potentially improving the results of clinical trials. Most likely, the key to success will be a multimodal approach employing novel imaging methods as well as large scale screening tools-summarized as "omics" approach. Using individually tailored therapies, plaque stabilization and regression could prevent adverse cardiovascular events thereby improving outcome of a large number of patients.
authors.affiliation: Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg, Germany. Electronic address: christian.gleissner@med.uni-heidelberg.de.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Gleissner
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology* / Q000628:therapy; D002309:Cardiology / Q000379:methods; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications; D051379:Mice; D008822:Mice, Transgenic; D057285:Precision Medicine / Q000379:methods; D057170:Translational Research, Biomedical / Q000379:methods*; D016896:Treatment Outcome
keywords: Atherosclerosis; Clinical trials; Coronary artery disease; Personalized medicine; Research; Therapy