title: About the numerical robustness of biomedical benchmark cases: Interlaboratory FDA's idealized medical device.
abstract: The need for reliable approaches in numerical simulations stands out as a critical issue for the development and optimization of cardiovascular biomedical devices. This led the US Food and Drug Administration to undertake a programme of validation of computational fluid dynamics methods for transitional and turbulent flows. In the current investigation, large-eddy simulation is used to simulate the flow in the first benchmark medical device, and results are confronted to the existing laboratory experiments. This idealized medical device has the particularity to feature transition to turbulence after a sudden expansion. The effects of numerical parameters and low-level inlet perturbations are investigated. Results indicate a considerable impact of numerical aspects on the prediction of the location of the transition to turbulence. The study also demonstrates that injecting small perturbations at the inflow greatly improves the streamwise velocity estimation in the transition region and substantially contributes to the robustness of the flow statistical data. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Institute of Montpellier Alexander Grothendieck - CNRS UMR5149 and University of Montpellier, Montpellier, 34095, France.
authors.forename: Vladeta
authors.identifier: 0000-0001-6642-1420
authors.initials: V
authors.lastname: Zmijanovic
authors.affiliation: Institute of Montpellier Alexander Grothendieck - CNRS UMR5149 and University of Montpellier, Montpellier, 34095, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Mendez
authors.affiliation: CORIA, CNRS, INSA and University of Rouen, Saint-Etienne-du-Rouvray, 76801, France.
authors.forename: Vincent
authors.identifier: 0000-0003-4574-7709
authors.initials: V
authors.lastname: Moureau
authors.affiliation: Institute of Montpellier Alexander Grothendieck - CNRS UMR5149 and University of Montpellier, Montpellier, 34095, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Nicoud
mesh_terms: D019985:Benchmarking; D003198:Computer Simulation; D004864:Equipment and Supplies / Q000592:standards*; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D014481:United States; D014486:United States Food and Drug Administration / Q000331:legislation & jurisprudence*
keywords: experimental-numerical validation; flow sensitivity; hemodynamics; large-eddy-simulation; perturbations; turbulence