title: Primary colorectal lymphoma comprising both components of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma combined with cytomegalovirus colitis.
abstract: A 16-year-old girl presented to our hospital with diarrhea and abdominal pain. The macroscopic findings of colonoscopy revealed multiple submucosal tumors and multiple ulcers, which were localized in the sigmoid colon, and diffuse granular mucosa which extended to the total colon. The pathological diagnosis was malignant lymphoma comprising both components of diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma, because the large lymphoma cells were CD20+, CD10-, and CD5-. Furthermore, immunohistochemical analysis of colorectal biopsy samples from multiple ulcers revealed cytomegalovirus (CMV)-positive cells. The patient was diagnosed with primary colorectal lymphoma comprising both components of DLBCL and MALT lymphoma combined with CMV colitis. She received anti-viral medication and chemotherapy.
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Katsumata
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan. hmatsumoto0311@gmail.com.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan.
authors.forename: Osawa
authors.initials: O
authors.lastname: Motoyasu
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Murao
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ishii
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujita
authors.affiliation: Division of Hematology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Tokunaga
authors.affiliation: Division of Pathology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiyama
authors.affiliation: Division of Hematology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Hideho
authors.initials: H
authors.lastname: Wada
authors.affiliation: Division of Hematology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugihara
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Shiotani
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 7100011, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003092:Colitis / Q000150:complications* / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000150:complications* / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000188:drug therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir
keywords: Colon; Cytomegalovirus; Malignant lymphoma; Mucosa associated lymphoid tissue (MALT) lymphoma