title: Chronic Myeloid Leukemia: A Case of Extreme Thrombocytosis Causing Syncope and Myocardial Infarction.
abstract: Chronic myeloid leukemia (CML), a hematologic malignancy characterized by unregulated growth of myelogenous leukocytes, typically presents with symptoms of fatigue, anorexia, and splenomegaly. Laboratory studies often reveal a significant leukocytosis with neutrophilia. A moderate thrombocytosis may be present, but is not usually problematic. The following case discusses a patient who presented with syncope, a convulsive episode, and non ST-segment myocardial infarction secondary to symptomatic thrombocytosis of 2.5 million cells/microL. She was treated with plateletpheresis and subsequently experienced resolution of symptoms. Ultimately, a diagnosis of CML with an atypical presentation of the disease was identified in this patient.
authors.affiliation: Internal Medicine, University of Kansas School of Medicine-Wichita.
authors.forename: Rawaa
authors.initials: R
authors.lastname: Ebrahem
authors.affiliation: Internal Medicine, University of Kansas School of Medicine-Wichita.
authors.forename: Brittany
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: Internal Medicine, University of Kansas School of Medicine-Wichita.
authors.forename: Salam
authors.initials: S
authors.lastname: Kadhem
authors.affiliation: Cancer Center of Kansas.
authors.forename: Quoc
authors.initials: Q
authors.lastname: Truong
keywords: apheresis; oncology; plateletpheresis; seizure; syncope