title: Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine.
abstract: BACKGROUND
  At present, much attention has been focused on the beneficial effects of natural products on the human health due to their high efficacy and low adverse effects. Among them, polyphenolic compounds are known as one of the most important and common classes of natural products, which possess multiple range of health-promotion effects including anti-inflammatory and antioxidant activities. A plethora of scientific evidence has shown that polyphenolic compounds possess beneficial effects on the central nervous system.
  
  
  METHODS
  Data were collected from Web of Science (ISI Web of Knowledge), Medline, Pubmed, Scopus, Embase, and BIOSIS Previews (from 1950 to 2015), through searching of these keywords: "chlorogenic acid and mental diseases" and "chlorogenic acid and neuroprotection".
  
  
  RESULTS
  Chlorogenic acid is known as one of the most common polyphenolic compounds, and is found in different types of fruits and vegetables, spices, wine, olive oil, as well as coffee. The potential neuroprotective effects of chlorogenic acid have been highlighted in several in vitro and in vivo studies. This review critically analyses the available scientific evidence regarding the neuroprotective effects of chlorogenic acid, and its neuropharmacological mechanisms of action. In addition, we also discuss its biosynthesis, sources, bioavailability and metabolism, to provide a broad perspective of the therapeutic implications of this compound in brain health and disease.
  
  
  CONCLUSIONS
  The present review showed that chlorogenic acid possesses neuroprotective effects under the both in vitro and in vivo models.
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Experimental Laboratory, Research Unit, Son Llàtzer Hospital, IUNICS, Ctra. Manacor km 4, E-07198, Palma de Mallorca, Balearic Islands, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Tejada
authors.affiliation: Department of Chemistry, University of Alabama in Huntsville, Alabama 35899, Huntsville, United States.
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
authors.affiliation: Department of Food Technology, Technological Educational Institution of Thessaly Terma N. Temponera Str., Greece.
authors.forename: Olga
authors.initials: O
authors.lastname: Gortzi
authors.affiliation: Grup de Nutrició Comunitària i Estrès Oxidatiu (IUNICS) and CIBERobn Universitat de les Illes Balears, Palma de Mallorca. Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Sureda
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydneyy. Australia.
authors.forename: Nady
authors.initials: N
authors.lastname: Braidy
authors.affiliation: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia. Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
authors.affiliation: Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran. Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Manayi
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487. Iran.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002726:Chlorogenic Acid / Q000494:pharmacology*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011618:Psychotic Disorders / Q000188:drug therapy
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D002726:Chlorogenic Acid
keywords: Antioxidant; chlorogenic acid; inflammation; neuroprotective; oxidative stress; polyphenolic