title: A Rare Concurrence of Leiomyomatosis Peritonealis Disseminata, Leiomyosarcoma of the Pelvis and Leiomyomatous Nodule of the Liver.
abstract: Leiomyomatosis peritonealis disseminata (LPD) is a rare entity that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules throughout the peritoneal surface mimicking a malignant process. LPD follows a benign course in general, and it is often found incidentally during abdominal surgery. There have been reported cases of LPD with malignant degeneration although the association is uncertain. Concurrent finding of LPD and leiomyosarcoma of the pelvis is very rare that could be coincidental, malignant transformation of LPD to leiomyosarcoma, or progression of undetected primary leiomyosarcoma. There are only a few previously reported cases in the literature. Herein, we report a case of 56-year-old woman with a history of leiomyoma of uterus who presented with progressive abdominal swelling secondary to mass lesions in the pelvis. The patient underwent exploratory laparotomy and debulking of the tumors, and the histologic examination of the tumors revealed coexistence of LPD and leiomyosarcoma. After recovery from the operation, core needle biopsy of the superficial, residual liver mass was obtained to investigate potential liver metastasis, and the histopathologic findings are consistent with leiomyoma which represents the first simultaneous occurrence of LPD, leiomyosarcoma, and leiomyomatous nodule of the liver.
authors.affiliation: Department of Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11201, USA.
authors.forename: Aung Myint
authors.identifier: 0000-0002-5245-2354
authors.initials: AM
authors.lastname: Tun
authors.affiliation: Health Pavilion North Cancer Center, Fayetteville, NC 28311, USA.
authors.forename: Nay Min
authors.identifier: 0000-0002-7476-8675
authors.initials: NM
authors.lastname: Tun
authors.affiliation: Department of Oncologic Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Kyaw
authors.initials: K
authors.lastname: Zin Thein
authors.affiliation: St. George's University School of Medicine, St. George's, Grenada.
authors.forename: Ei Ei
authors.initials: EE
authors.lastname: Naing
authors.affiliation: Department of Pathology and Laboratory Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11201, USA.
authors.forename: Shah
authors.initials: S
authors.lastname: Giashuddin
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, The Brooklyn Hospital Center, Brooklyn, NY 11201, USA.
authors.forename: Maxim
authors.initials: M
authors.lastname: Shulimovich