title: Penimethavone A, a flavone from a gorgonian-derived fungus Penicillium chrysogenum.
abstract: A novel flavone, penimethavone A (1), possessing a rare unique methyl group at ring-B, was isolated from the fungus Penicillium chrysogenum cultured from a gorgonian Carijoa sp. collected from the South China Sea. The structure was elucidated by extensive spectroscopic analysis and by comparison with related known compound. Compound 1 showed selective and moderate cytotoxicity against cervical cancer (HeLa) and rhabdomyosarcoma cell lines with IC50 values of 8.41 and 8.18 μM, respectively.
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Hou
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.|b Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao , P.R. China.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
authors.affiliation: c Syngenta Jealott's Hill International Research Centre , Bracknell , UK.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.|b Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao , P.R. China.
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000382:microbiology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry; D010408:Penicillium chrysogenum / Q000737:chemistry*; D012208:Rhabdomyosarcoma / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D047309:Flavones; C000619082:penimethavone A
keywords: Penicillium chrysogenum; cytotoxicity; flavone; gorgonian Carijoa sp