title: Minimal effective dose of povidone-iodine in abdominal surgery Our clinical experience.
abstract: The aim of this study is to evaluate the thyroid function tests in order to examine whether 10 % of Povidone-Iodine(PI), the medication we applied in 1/5 ratio diluted with 0.9 %NaCl, joins the systemic circulation during clean contaminated, contaminated and dirty operations for solid organ hydatid cysts in abdominal area to avoid abscess formation and spreading. 7 men and 6 women were included to the present study, prospectively. The mean age was 33.69(± 13.49). TSH, free T3 (fT3) and free T4 (fT4) hormone levels were measured before the operation and at the third day of postoperative period. Amount of used povidone-iodine for patients was recorded. As a result of statistical analysis applied, the preoperative and post operative values were not significantly different regarding with the measured hormone levels (preTSH vs postTSH: p= 0.984; prefT3 vs postfT3: p= 0.101; prefT4 vs postfT4: p=0.146). Thus, it has been shown that the dose we used is effective, and it does not enters at all or at quite low levels into the systemic circulation. Patients whom this application performed, abscess and intestinal adhesions have not been observed in our clinical experience. We recommend the use of suggested doses of Povidone-Iodine in the presence of intraabdominal perforation and abscess or in cases such as carrying a risk of cyst spreading to intraabdominal area in hydatid cysts.
  
  
  BACKGROUND
  Povidone-iodine, Surgical adhesions, Surgical wound infections, Thyroid function tests.
authors.forename: Orhan
authors.initials: O
authors.lastname: Gozeneli
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yucel
authors.forename: Ali
authors.initials: A
authors.lastname: Akal
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Terzi
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozgonul
authors.forename: Faik
authors.initials: F
authors.lastname: Tatli
authors.forename: Resit
authors.initials: R
authors.lastname: Ciftci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gumer
authors.forename: Ali
authors.initials: A
authors.lastname: Uzunkoy
mesh_terms: D000005:Abdomen; D000038:Abscess / Q000517:prevention & control; D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004443:Echinococcosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011184:Postoperative Period; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D011446:Prospective Studies; D012869:Skin Absorption; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013961:Thyroid Gland / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood; D000267:Tissue Adhesions / Q000139:chemically induced / Q000517:prevention & control; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D014284:Triiodothyronine; D011206:Povidone-Iodine; D013974:Thyroxine