title: Synthetic approaches to the 2014 new drugs.
abstract: New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of thirty-seven NCEs that were approved for the first time in 2014 and one drug which was approved in 2013 and was not covered in a previous edition of this review.
authors.affiliation: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: andrew.flick@pfizer.com.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Flick
authors.affiliation: Pharmacodia (Beijing) Co., Ltd, Beijing 100085, China. Electronic address: Sheryl.ding@pharmacodia.com.
authors.forename: Hong X
authors.initials: HX
authors.lastname: Ding
authors.affiliation: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: carolyn.a.leverett@pfizer.com.
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Leverett
authors.affiliation: Celgene Avilomics Research, 200 Cambridge Park Drive, Cambridge, MA 02140, United States. Electronic address: rkyne@celgene.com.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Kyne
authors.affiliation: China Novartis Institutes for BioMedical Research Co., Ltd, Shanghai 200131, China. Electronic address: kevin.liu@novartis.com.
authors.forename: Kevin K-C
authors.initials: KK
authors.lastname: Liu
authors.affiliation: BioDuro Co., Ltd, Shanghai 200131, China. Electronic address: sarah.fink@bioduro.com.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Fink
authors.affiliation: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: christopher.j.odonnell@pfizer.com.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Donnell
mesh_terms: D003132:Commerce; D015195:Drug Design; D004345:Drug Industry
keywords: Medicine; New chemical entities; New drug molecules; Synthesis; Therapeutic agents