title: Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: case report.
abstract: Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.
authors.affiliation: Department of Neurosurgery;
authors.forename: Marta
authors.initials: M
authors.lastname: Cicuendez
authors.affiliation: Department of Neuropathology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Martinez-Saez
authors.affiliation: Department of Neurosurgery, Neurotraumatology, and Neurosurgery Research Unit; and.
authors.forename: Francisco
authors.initials: F
authors.lastname: Martinez-Ricarte
authors.affiliation: Department of Neurosurgery;
authors.forename: Esteban Cordero
authors.initials: EC
authors.lastname: Asanza
authors.affiliation: Department of Neurosurgery, Neurotraumatology, and Neurosurgery Research Unit; and.
authors.forename: Juan
authors.initials: J
authors.lastname: Sahuquillo
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D018303:Ganglioglioma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF mutation; GFAP = glial fibrillary acidic protein; GG = ganglioglioma; PCR = polymerase chain reaction; PXA = pleomorphic xanthoastrocytoma; combined pleomorphic xanthoastrocytoma-ganglioglioma; ganglioglioma; oncology; pleomorphic xanthoastrocytoma