title: [Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries].
abstract: The spread of the HIV-1circular recombinant CRF02-AG in countries of the former Soviet union (Commonwealth of Independent States, CIS) was studies using partial and full genome sequences. The full-genome sequence of the CRF02-AG recombinant circulating in Russia was obtained for the first time. A Global phylogenetic tree of CRF02-AG full-genome sequences was constructed. Three distinct groups of the sequences were detected as clustered by the geographical location (CIS, South Korea, and France), which is indicative of the single-virus introduction in each of the regions mentioned above. The CIS cluster exhibiting minimum genetic diversity was, therefore, relatively young. The phylogenetic analysis of the env gene sequences within the CIS cluster made it possible to clearly discriminate three branches: two of Russian and one of Uzbek origin. The low genetic diversity within the two Russian subclusters provides evidence of at least two recent independent introductions of the CRF02-AG recombinant from Central Asia into Russia. This work was performed within the framework of the 7th Federal Research Program (FP&), Project EURIPRED (European Research Infrastructures for Poverty Related Diseases), grant agreement No.312661.
authors.forename: F F
authors.initials: FF
authors.lastname: Moskaleychik
authors.forename: V Yu
authors.initials: VY
authors.lastname: Laga
authors.forename: E
authors.initials: E
authors.lastname: Delgado
authors.forename: Y
authors.initials: Y
authors.lastname: Vega
authors.forename: A
authors.initials: A
authors.lastname: Fernandez-Garcia
authors.lastname: Perez-Alvarez
authors.forename: G V
authors.initials: GV
authors.lastname: Kornilaeva
authors.forename: A Yu
authors.initials: AY
authors.lastname: Pronin
authors.forename: Yu V
authors.initials: YV
authors.lastname: Zhernov
authors.forename: M M
authors.initials: MM
authors.lastname: Thomson
authors.forename: M R
authors.initials: MR
authors.lastname: Bobkova
authors.forename: E V
authors.initials: EV
authors.lastname: Karamov
mesh_terms: D017517:Commonwealth of Independent States / Q000453:epidemiology; D005260:Female; D005602:France / Q000453:epidemiology; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000523:psychology / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D005810:Multigene Family; D010802:Phylogeny; D016865:Reassortant Viruses / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D011995:Recombination, Genetic; D056910:Republic of Korea / Q000453:epidemiology; D012309:Risk-Taking; D015819:Substance Abuse, Intravenous / Q000523:psychology; D047568:Unsafe Sex / Q000523:psychology / Q000706:statistics & numerical data