title: Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker.
abstract: There are urgent demands for satisfactory antibacterial activity and mechanical properties of bone scaffolds. In this study, zinc oxide whisker (ZnOw) was introduced into calcium sulfate/bioglass scaffolds. Antimicrobial behavior was analyzed using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results showed that the scaffolds presented a strong antibacterial activity after introducing ZnOw, due to the antibacterial factors released from the degradation of ZnO. Moreover, ZnOw was also found to have a distinct reinforcing effect on mechanical properties. This was ascribed to whisker pull-out, crack bridging, crack deflection, crack branching and other toughening mechanisms. In addition, the cell culture experiments showed that the scaffolds with ZnOw had a good biocompatibility.
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. shuai@csu.edu.cn.|Shenzhen Research Institute, Central South University, Shenzhen 518057, China. shuai@csu.edu.cn.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. zhouyx@csu.edu.cn.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Basic Medical Science, Central South University, Changsha 410078, China. gd146611004@csu.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. gaochengde@csu.edu.cn.
authors.forename: Chengde
authors.initials: C
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. fengpei@csu.edu.cn.
authors.forename: Pei
authors.initials: P
authors.lastname: Feng
authors.affiliation: School of Basic Medical Science, Central South University, Changsha 410078, China. shuping@csu.edu.cn.
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects*; D002133:Calcium Sulfate / Q000737:chemistry; D018929:Cell Culture Techniques; D002516:Ceramics / Q000737:chemistry / Q000627:therapeutic use*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D013211:Staphylococcus aureus / Q000187:drug effects; D054457:Tissue Scaffolds / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; C022107:Bioglass; D015034:Zinc Oxide; D002133:Calcium Sulfate
keywords: antibacterial activity; biocompatibility; mechanical property; scaffolds; zinc oxide whisker