title: Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats.
abstract: Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosage can produce fatal centrilobular hepatic necrosis in humans. The present study attempted to investigate the protective effect of an anthocyanin-rich extract from bilberries and blackcurrants (AE) against APAP-induced acute hepatic damage in rats. Treatment with AE normalised blood activities of glutamate oxaloacetate and glutamate pyruvate transaminase and prevented APAP-induced plasmatic and tissutal alterations in biomarkers of oxidative stress, probably due to various bioproperties of the components of the extract.
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cristani
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Speciale
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: F
authors.initials: F
authors.lastname: Mancari
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: T
authors.initials: T
authors.lastname: Arcoraci
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: D
authors.initials: D
authors.lastname: Ferrari
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: D
authors.initials: D
authors.lastname: Fratantonio
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Saija
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cimino
authors.affiliation: a Department of Drug Sciences and Health Products , University of Messina , Messina , Italy.
authors.forename: D
authors.initials: D
authors.lastname: Trombetta
keywords: Acetaminophen; anthocyanin; biomarkers; hepatoprotection; oxidative stress