title: Maternal and perinatal outcomes of pregnancies in women with cystic fibrosis--A single centre case-control study.
abstract: BACKGROUND
  Due to increased survival, more women with cystic fibrosis become pregnant. However, studies on the specificities of pregnancy in CF versus healthy women are lacking.
  
  
  METHODS
  In this retrospective case-control study, we compared the maternal and perinatal outcomes of 33 pregnancies in CF women who delivered in our maternity ward from December 2000 to December 2013 and were matched to 66 controls.
  
  
  RESULTS
  The median term of delivery was similar in cases and controls (38.1 ± 1.6 vs 38.4 ± 1.1 weeks gestation). Assisted reproductive technology pregnancies were more frequent in CF women (51% vs 3%, p < 0.001). In CF women, the initial BMI was lower (mean BMI 19.5 ± 2.4 vs 22.4 ± 4.9 kg/m(2); p = 0.001) and pre-existing diabetes was more frequent (30% vs 3%; p < 0.001). Those differences persisted during pregnancy for weight gain (9.1 ± 7.1 kg vs 13.3 ± 6.4 kg; p = 0.001) and diabetes (48% vs 8%; p < 0.001). Spontaneous labor and vaginal deliveries were less frequent in CF than in controls (respectively 45% vs 70%, p = 0.002; 51% vs 70%, p = 0.11). There was an equal number of caesarean sections (24% vs 21%; p = 0.80). Neonatal outcomes were similar in both groups, including birth weight (3042 ± 91 g vs 3119 ± 92 g).
  
  
  CONCLUSIONS
  Multidisciplinary care of pregnancy in women with CF resulted in maternal and perinatal outcomes similar to those found in women in the general population.
authors.affiliation: Maternité Port-Royal, Université Paris-Descartes, DHU Risk in Pregnancy, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Girault
authors.affiliation: Maternité Port-Royal, Université Paris-Descartes, DHU Risk in Pregnancy, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Blanc
authors.affiliation: Unité de Médecine de la Reproduction, service de Gynécologie-Obstétrique, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gayet
authors.affiliation: Maternité Port-Royal, Université Paris-Descartes, DHU Risk in Pregnancy, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM U1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS), Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Goffinet
authors.affiliation: Centre de ressources et de compétences de la mucoviscidose, service de pneumologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: dominique.hubert@aphp.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hubert
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000503:physiopathology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data; D012189:Retrospective Studies
keywords: Assisted reproductive technology; Cystic fibrosis; Diabetes; Pregnancy