title: Small flexible structure for targeted delivery of therapeutic and imaging moieties in precision medicine.
abstract: The goals of precision medicine are to link diagnostic and therapeutic agents, improve clinical outcomes, and minimize side effects. We present a simple, small, flexible three-armed core structure that can be conjugated to targeting, imaging, and therapeutic moieties. The targeting molecule can be a peptide, protein, or chemical compound. The diagnostic reporter can be optical and/or nuclear in nature, and can be replaced by chemo- and/or radiotherapeutic compounds for treatment using a single targeting molecule. Imaging components can be used to detect disease biomarkers, monitor treatment response, and guide surgery in real-time to create a tumor-free margin. Isotope impurity can be exploited to visualize whole-body distribution of therapeutic agents. The one-to-one ratio of targeting component to therapeutic agents facilitates dose calculation. The simple synthesis and flexible, modular nature of the agent facilitate high-purity, large-scale production. The core capacity to "seek, treat, and see" may advance precision medicine in the future.
authors.affiliation: UTHealth, School of Public Health, Houston, Texas, USA.|Jiangxi Children's Hospital, Nanchang, China.
authors.forename: Shaofan
authors.initials: S
authors.lastname: Hu
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Biotechnology, Southern Medical University, Guangzhou, China.|Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: UTHealth, School of Public Health, Houston, Texas, USA.
authors.forename: Bingjie
authors.initials: B
authors.lastname: Li
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.|The Fourth Military Medical University, Xi'an, China.
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.|Harbin Medical University, Harbin, China.
authors.forename: Chaoxia
authors.initials: C
authors.lastname: Zou
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Henry
authors.initials: H
authors.lastname: Ran
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.|Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
authors.forename: Fujun
authors.initials: F
authors.lastname: Zhang
authors.affiliation: UTHealth, School of Public Health, Houston, Texas, USA.|Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Shi
authors.initials: S
authors.lastname: Ke
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*
keywords: molecule imaging; molecule therapy; precision medicine; target-specific imaging; target-specific therapy