title: Cinnamomum camphora Seed Kernel Oil Ameliorates Oxidative Stress and Inflammation in Diet-Induced Obese Rats.
abstract: Cinnamomum camphora seed kernel oil (CCSKO) was found to reduce body fat deposition and improve blood lipid in both healthy and obese rats. The study was aimed to investigate the antioxidative stress and anti-inflammatory effects of CCSKO in high-fat-diet-induced obese rats. The obese rats were treated with CCSKO, lard, and soybean oil, respectively, for 12 wk. The level of total antioxidant capacity (T-AOC), activities of superoxide dismutase (SOD), glutathione peroxidase, and catalase, and levels of malondialdehyde (MDA), tumor necrosis factor (TNF)-α, peroxisome proliferator-activated receptor (PPAR)-γ, interleukin (IL)-6, and P65 were compared among CCSKO, lard, and soybean oil groups. Our results showed that the level of T-AOC and activities of SOD and catalase were significantly increased and the level of MDA was significantly decreased in CCSKO group. In addition, CCSKO treatment reduced the activities of serum glutamic oxaloacetic transaminase and glutamate-pyruvate transaminase, and levels of serum TNF-α, IL-6, and P65 through raising the level of PPAR-γ. In conclusion, CCSKO has, for the first time, been found to ameliorate oxidative stress and inflammation in high-fat-diet-induced obese rats.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang Univ, 235 Nanjing East Rd., Nanchang, 330047, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
authors.affiliation: the First Clinical School, Nanchang Univ, Nanchang, 330031, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang Univ, 235 Nanjing East Rd., Nanchang, 330047, China.|the School of Environmental and Chemical Engineering, Nanchang Univ, Nanchang, 330031, China.
authors.forename: Zheling
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang Univ, 235 Nanjing East Rd., Nanchang, 330047, China.
authors.forename: Baogui
authors.initials: B
authors.lastname: Wang
authors.affiliation: School of Biological Sciences, The Univ. of Auckland, Private Bag, 92019, Auckland, New Zealand.
authors.forename: Deming
authors.initials: D
authors.lastname: Gong
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D002374:Catalase / Q000378:metabolism; D027423:Cinnamomum camphora / Q000737:chemistry*; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D005979:Glutathione Peroxidase / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009765:Obesity / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D047495:PPAR gamma / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012639:Seeds / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004041:Dietary Fats; D015850:Interleukin-6; D047495:PPAR gamma; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Cinnamomum camphora seed kernel oil; inflammation; oxidative stress