title: History of chromosome rearrangements reflects the spatial organization of yeast chromosomes.
abstract: Three-dimensional (3D) organization of genomes affects critical cellular processes such as transcription, replication, and deoxyribo nucleic acid (DNA) repair. While previous studies have investigated the natural role, the 3D organization plays in limiting a possible set of genomic rearrangements following DNA repair, the influence of specific organizational principles on this process, particularly over longer evolutionary time scales, remains relatively unexplored. In budding yeast S.cerevisiae, chromosomes are organized into a Rabl-like configuration, with clustered centromeres and telomeres tethered to the nuclear periphery. Hi-C data for S.cerevisiae show that a consequence of this Rabl-like organization is that regions equally distant from centromeres are more frequently in contact with each other, between arms of both the same and different chromosomes. Here, we detect rearrangement events in Saccharomyces species using an automatic approach, and observe increased rearrangement frequency between regions with higher contact frequencies. Together, our results underscore how specific principles of 3D chromosomal organization can influence evolutionary events.
authors.affiliation: 1 Institute for Information Transmission, Problems (the Kharkevich Institute), Russian Academy of Sciences, Bolshoy Karetny per. 19, build. 1, Moscow 127051, Russian Federation.|2 Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, build. 3, Moscow 143026, Russian Federation.
authors.forename: Ekaterina E
authors.identifier: 0000-0001-6188-9139
authors.initials: EE
authors.lastname: Khrameeva
authors.affiliation: 3 Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Fudenberg
authors.affiliation: 1 Institute for Information Transmission, Problems (the Kharkevich Institute), Russian Academy of Sciences, Bolshoy Karetny per. 19, build. 1, Moscow 127051, Russian Federation.|4 Faculty of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Leninskiye Gory 1-73, Moscow 119991, Russian Federation.
authors.forename: Mikhail S
authors.initials: MS
authors.lastname: Gelfand
authors.affiliation: 3 Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Leonid A
authors.initials: LA
authors.lastname: Mirny
mesh_terms: D000465:Algorithms; D015825:Chromosomes, Fungal / Q000737:chemistry / Q000235:genetics; D015321:Gene Rearrangement; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015003:Yeasts / Q000235:genetics*
keywords: Hi-C; Rearrangements; Saccharomyces cerevisiae; chromatin; chromosomes; translocations; yeasts