title: A case of anti-NMDA receptor encephalitis in a woman with a NMDA-R(+) small cell lung carcinoma (SCLC).
abstract: The association of small cell lung cancer with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is rare. We report a 62 year old patient who developed psychiatric disorders followed by epilepsy, movement disorders, mutism and hypoventilation. Flair weighted brain MRI sequences showed diffuse high signals in the limbic system. Anti-NMDAR antibodies were detected in the serum and CSF. The patient's IgGs reacted with the patient's own tumor cells and with 2 out of 4 small cell lung cancers of patients without neurological syndrome.
authors.affiliation: GIMAP EA3064, Laboratory of Immunology and Immunomonitoring, CIC 1408 Inserm Vaccinology, Hopital Nord, CHU Saint-Etienne, France.
authors.forename: M
authors.initials: M
authors.lastname: Jeraiby
authors.affiliation: GIMAP EA3064, Laboratory of Immunology and Immunomonitoring, CIC 1408 Inserm Vaccinology, Hopital Nord, CHU Saint-Etienne, France.
authors.forename: A
authors.initials: A
authors.lastname: Depincé-Berger
authors.affiliation: GIMAP EA3064, Laboratory of Immunology and Immunomonitoring, CIC 1408 Inserm Vaccinology, Hopital Nord, CHU Saint-Etienne, France.
authors.forename: V
authors.initials: V
authors.lastname: Bossy
authors.affiliation: Neurology Department, Hopital Nord, CHU Saint-Etienne, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Antoine
authors.affiliation: GIMAP EA3064, Laboratory of Immunology and Immunomonitoring, CIC 1408 Inserm Vaccinology, Hopital Nord, CHU Saint-Etienne, France. Electronic address: stephane.paul@chu-st-etienne.fr.
authors.forename: S
authors.initials: S
authors.lastname: Paul
mesh_terms: D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000175:diagnosis / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D057809:HEK293 Cells; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008175:Lung Neoplasms / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D008875:Middle Aged; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D055752:Small Cell Lung Carcinoma / Q000097:blood / Q000276:immunology* / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Anti-NMDA receptor; Paraneoplastic encephalitis and immunocytochemistry; SCLC