title: Disrupted amplitude of low-frequency fluctuations in antipsychotic-naïve adolescents with early-onset schizophrenia.
abstract: Evidence points to a crucial role for altered neural oscillations and synchrony in the pathophysiology of schizophrenia. Previous resting state functional magnetic resonance imaging (fMRI) studies found aberrant amplitudes of low-frequency oscillations in adult patients with schizophrenia. Whether the abnormality is also present in adolescents with early-onset schizophrenia (EOS) is largely unknown. We recruited 39 adolescents with a first episode of EOS and 31 age- and education- matched healthy controls. Resting state fMRI was obtained using an echo-planar imaging sequence. Voxel-wise amplitude of low-frequency (0.01-0.08Hz) fluctuations (ALFF) was compared between groups. We investigated seed-based functional connectivity between significantly disturbed ALFF regions and whole brain voxels in all participants. EOS participants exhibited significantly increased ALFF values in the orbitofrontal cortex (OFC) and decreased ALFF in the ventral precuneus compared with controls. Decreased ALFF values in the precuneus of EOS showed a significant negative correlation with negative symptom scores on the Positive and Negative Syndrome Scale. Disturbed functional connectivity mainly occurred between the orbitofrontal cortex and the temporal cortex in EOS. These findings demonstrate abnormal spontaneous neuronal activity and functional connectivity in the frontal and parietal cortex of EOS. Aberrant ALFF in the precuneus might be a biomarker of EOS.
authors.affiliation: Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology and Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology and Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 610054, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Guo
authors.affiliation: Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology and Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 610054, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
authors.forename: Xujun
authors.initials: X
authors.lastname: Duan
authors.affiliation: Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology and Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: chenhf@uestc.edu.cn.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology and Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address: zhaojingpingcsu@163.com.
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology
keywords: Amplitude of low-frequency fluctuations; Early-onset schizophrenia; Functional connectivity; Positive and Negative Syndrome Scale; Resting-state fMRI