title: Safety and effectiveness of divalproex sodium extended release containing regimen in Indian patients with bipolar I disorder in continuation phase: Results of EASED registry.
abstract: The study was conducted to evaluate the safety and effectiveness of divalproex sodium XR containing regimen in patients with bipolar disorder (BPD) who are in continuation phase. It was an open-label, prospective, observational study conducted from July 2010 to December 2011 at 48 sites across India. Adult patients with bipolar I disorder of manic or mixed type fulfilling the DSM-IV criteria and who were in the continuation phase were included. Safety (primary outcome) was assessed by incidence of treatment emergent adverse events (AEs). Effectiveness (secondary outcome), was evaluated by proportion of patients who did not have a relapse, change in Clinical Global Impression Score-BP version-Severity of Illness (CGI-BP) and Young's Mania Rating Scale (YMRS) score. Data was recorded at three visits: visit-1 (baseline), visit-2 (end of 2 months ± 7 days) and visit-3 (end of 4 months ± 14 days), and summarised using descriptive statistics. p<0.05 was considered statistically significant. A total of 489 and 468 patients were included in the safety and effectiveness analyses, respectively. Of the 66 AEs reported, 57 (89.0%) were mild and 7 (10.9%) were moderate (data missing for 2 events). In total, 75.0% (48/64) of the AEs were related to the study drug. No serious AEs reported (N=64). No relapse observed in 93.3% of patients. There was a significant (p<0.0001) reduction in the YMRS and CGI-BP scores from baseline to visit-3. Our study confirms the results of earlier studies in terms of good tolerability and effectiveness of divalproex sodium XR containing regimen in this study population.
authors.affiliation: L. T. M. Medical College and General Hospital, Mumbai, India. Electronic address: drnilshah@hotmail.com.
authors.forename: Nilesh
authors.initials: N
authors.lastname: Shah
authors.affiliation: Asha Bipolar Clinic, Asha Hospital, Hyderabad, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Reddy
authors.affiliation: Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Vohra
authors.affiliation: Gaurinath Shastri Memorial Clinic, Kolkata, India.
authors.forename: Uday
authors.initials: U
authors.lastname: Chaudhuri
authors.affiliation: Sanofi, Mumbai, India.
authors.forename: Senthilnathan
authors.initials: S
authors.lastname: Mohanasundaram
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D012042:Registries; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D018692:Antimanic Agents; D003692:Delayed-Action Preparations; D014635:Valproic Acid
keywords: Bipolar disorder; Depression; Mania; Safety; Valproic acid