title: Demonstration of synchrotron x-ray phase contrast imaging computed tomography of infiltrative transitional cell carcinoma of the prostatic urethra in a dog.
abstract: Prostatic urethral transitional cell carcinoma with prostatic invasion in a dog was imaged with abdominal radiography and abdominal ultrasonography antemortem. Synchrotron in-line x-ray phase contrast imaging computed tomography (XPCI-CT) was performed on the prostate ex vivo at the Canadian Light Source Synchrotron and compared to histology. XPCI-CT imaging provides greater soft tissue contrast than conventional absorption-based x-ray imaging modalities, permitting visualization of regions of inflammatory cell infiltration, differentiation of invasive versus noninvasive tumor regions, and areas of necrosis and mineralization. This represents the first report of XPCI-CT images of an invasive prostatic urothelial neoplasm in a dog.
authors.affiliation: University of Saskatchewan , College of Medicine, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada.
authors.forename: James E
authors.initials: JE
authors.lastname: Montgomery
authors.affiliation: University of Saskatchewan , Department of Medical Imaging, College of Medicine, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada.
authors.forename: Michal J
authors.initials: MJ
authors.lastname: Wesolowski
authors.affiliation: University of Saskatchewan , Department of Animal and Poultry Science, College of Agriculture and Bioresources, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada.
authors.forename: Bailey
authors.initials: B
authors.lastname: Wolkowski
authors.affiliation: University of Saskatchewan , Department of Pathology and Laboratory Medicine, College of Medicine, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada.
authors.forename: Rajni
authors.initials: R
authors.lastname: Chibbar
authors.affiliation: University of Saskatchewan , Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
authors.forename: Elisabeth C R
authors.initials: EC
authors.lastname: Snead
authors.affiliation: University of Saskatchewan , Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
authors.forename: Jaswant
authors.initials: J
authors.lastname: Singh
authors.affiliation: University of Saskatchewan , Department of Animal and Poultry Science, College of Agriculture and Bioresources, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada.
authors.forename: Murray
authors.initials: M
authors.lastname: Pettitt
authors.affiliation: Prairie Diagnostic Services , 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
authors.forename: Pritpal S
authors.initials: PS
authors.lastname: Malhi
authors.affiliation: University of Saskatchewan , Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
authors.forename: Trinita
authors.initials: T
authors.lastname: Barboza
authors.affiliation: University of Saskatchewan , Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
authors.forename: Gregg
authors.initials: G
authors.lastname: Adams
keywords: computed tomography; prostate cancer; synchrotron imaging; transitional cell carcinoma; x-ray phase contrast imaging