title: Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs.
abstract: The main group of enzymes responsible for the collagen and other protein degradation in extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main structural component of connective tissue and its degradation is a very important process in the development, morphogenesis, tissue remodeling, and repair. Typical structure of MMPs consists of several distinct domains. MMP family can be divided into six groups: collagenases, gelatinases, stromelysins, matrilysins, membrane-type MMPs, and other non-classified MMPs. MMPs and their inhibitors have multiple biological functions in all stages of cancer development: from initiation to outgrowth of clinically relevant metastases and likewise in apoptosis and angiogenesis. MMPs and their inhibitors are extensively examined as potential anticancer drugs. MMP inhibitors can be divided into two main groups: synthetic and natural inhibitors. Selected synthetic inhibitors are in clinical trials on humans, e.g. synthetic peptides, non-peptidic molecules, chemically modified tetracyclines, and bisphosphonates. Natural MMP inhibitors are mainly isoflavonoids and shark cartilage.
authors.affiliation: a Department of Sanitary Biology and Biotechnology , Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology , Białystok , Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Jabłońska-Trypuć
authors.affiliation: a Department of Sanitary Biology and Biotechnology , Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology , Białystok , Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Matejczyk
authors.affiliation: a Department of Sanitary Biology and Biotechnology , Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology , Białystok , Poland.
authors.forename: Stanisław
authors.initials: S
authors.lastname: Rosochacki
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D003094:Collagen / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D061965:Matrix Metalloproteinase Inhibitors; D003094:Collagen; D020782:Matrix Metalloproteinases
keywords: Angiogenesis; apoptosis; cancer; collagen; metalloproteinase; metalloproteinase inhibitor; metastasis