title: Transplantations from HLA-identical siblings versus 10/10 HLA-matched unrelated donors.
abstract: The clinical outcome after allogeneic stem cell transplantation from a human leukocyte antigen (HLA)-matched sibling donor as well as an HLA-matched unrelated donor has clearly improved due in part to the progress made in the domains of HLA-typing techniques. Although HLA-matched sibling transplantation is still held as the "gold standard," transplantation from HLA-A, -B, -C, -DRB1, and -DQB1-matched unrelated donors (so called 10/10) represent the first choice for patients without a suitable related donor. Several studies have shown that unmanipulated marrow transplantation from an HLA allele-matched unrelated donor resulted in similar outcomes to those observed following sibling transplantation. However, incorporating anti-thymocyte globulin (ATG) within graft-versus-host disease (GVHD) prophylaxis should be considered for peripheral blood stem cell grafts in order to decrease the risk of developing chronic GVHD.
authors.affiliation: LIRIC, INSERM U995, University Lille 2, Lille, France; UAM allo-CSH, University Hospital of Lille, Lille, France. Electronic address: Ibrahim.yakoubagha@chru-lille.fr.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yakoub-Agha
mesh_terms: D006086:Graft vs Host Disease / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D035781:Siblings; D033581:Stem Cell Transplantation; D016896:Treatment Outcome; D061349:Unrelated Donors
chemical_list: D006649:Histocompatibility Antigens
keywords: 10/10; HLA-matched; Sibling; Unrelated donor