title: 20(S)-Protopanaxadiol saponins inhibit SKOV3 cell migration.
abstract: While the anti-tumor actions of ginsenosides fromPanax notoginsengare well-studied, the anti-proliferative activity of 20(S)-protopanaxadiol saponins (PDS) in Sanchi ginseng on human ovarian cancer has not been reported, nor has its effect on migration of SKOV3 cells been investigated. In the present study, a wound-healing assay indicated that PDS inhibited the migration of SKOV3 cells, and a Matrigel™ tube formation assay demonstrated the presence of inhibitory tube-structures following treatment with PDS. To date, there are no previous reports on the regulation of osteopontin (OPN), a glycophosphoprotein cytokine frequently expressed in ovarian carcinoma effusions by PDS. A reduction in the expression of OPN following PDS-treatment was observed using immunohistochemical and western blot experiments. These results suggest that PDS may be useful in the search for a potential ovarian cancer treatment.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Pharmacy, School of Chemical Sciences and Technology, Yunnan University, Kunming, Yunnan 650091, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Pharmacy, School of Chemical Sciences and Technology, Yunnan University, Kunming, Yunnan 650091, P.R. China.
authors.forename: Daomei
authors.initials: D
authors.lastname: Chen
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming, Yunnan 650223, P.R. China.
authors.forename: Wanyi
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming, Yunnan 650223, P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xiao
keywords: Panax notoginseng saponins; SKOV3 cells; migration; ostopontin; ovarian cancer; tube formation