title: [Detection of neutralizing antibodies and DNA of human papillomavirus 16, 18 in women aged 18-45 years in Funing, Jiangsu province].
abstract: OBJECTIVE
  To understand the distributions of DNA and neutralizing antibodies of human papillomavirus (HPV)16, 18 in 18-45 year-old women.
  
  
  METHODS
  Totally, 1494 women were enrolled through multistage random sampling in Funing, Jiangsu province. Cervical exfoliated cells were collected from them for HPV DNA testing, and serum samples were taken from them for the detection of HPV16, 18 neutralizing antibodies by using pseudovirion-based neutralization assay(PBNA).
  
  
  RESULTS
  Among the 1494 women, 28(1.9%) and 188(12.6%) were positive for DNA and neutralizing antibody of HPV16 respectively, and 15(1.0%) and 60(4.0%) were positive for DNA and neutralizing antibody of HPV18, respectively. There were no significant differences in the detection rates of DNA and neutralizing antibody of HPV16, 18 among different age groups. About 16.7% of the women were infected with HPV16, 18, or both.
  
  
  CONCLUSIONS
  In Funing county of Jiangsu province, most women aged 18-45 years has no immunity to HPV16 and 18, indicating that they are appropriate targets for HPV 16/18 vaccination.
authors.affiliation: Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361100, China.
authors.forename: Feixue
authors.initials: F
authors.lastname: Wei
authors.affiliation: Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China.
authors.forename: Shangbo
authors.initials: S
authors.lastname: Yang
authors.affiliation: Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China.
authors.forename: Yachun
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chu
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: Yuemei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: Fengcai
authors.initials: F
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D057134:Antibodies, Neutralizing / Q000302:isolation & purification*; D000914:Antibodies, Viral / Q000302:isolation & purification*; D002681:China; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology*; D052161:Human papillomavirus 18 / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000517:prevention & control; D053918:Papillomavirus Vaccines; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D004279:DNA, Viral; D053918:Papillomavirus Vaccines