title: Factors Influencing the Outcome of Ultrasound-Guided Fine-Needle Aspiration for Salivary Gland Lesion Diagnosis.
abstract: OBJECTIVE
  This study aimed to assess multiple factors influencing the outcomes of ultrasound (US)-guided fine-needle aspiration (FNA) of salivary gland lesions.
  
  
  METHODS
  From 2008 to 2013, a single radiologist performed US-guided FNA of salivary gland lesions in 243 patients. With the exclusion of pure cysts, poor image quality, and insufficient static image cases, 218 salivary gland lesions in 218 patients were included. The composition, size, location, and vascularity of the lesions were retrospectively investigated on the basis of sonographic findings by the same radiologist. The relationship between sampling adequacy and multiple factors was compared, and the diagnostic accuracy of US-guided FNA of salivary gland lesions was calculated by using the final diagnosis as a reference standard.
  
  
  RESULTS
  The sampling adequacy rate for US-guided FNA of the 218 salivary gland lesions was 96.8% (211 of 218). A significant difference was observed in the composition and vascularity of the lesions (P < .0001), whereas there was no significant difference in the patient age and sex, lesion size, lesion location, and needle size. The rate of inadequate sampling increased in predominantly cystic lesions compared with solid lesions as well as in low-vascularity lesions compared with high-vascularity lesions. Of the 218 lesions, 178 (81.7%) were ultimately diagnosed, and most were benign (162 of 178 [91.0%]). When 3 cases with indeterminate cytologic results were excluded, the sensitivity, specificity, positive and negative predictive values, and accuracy of US-guided FNA of salivary gland lesions were 64.3%, 98.8%, 81.8%, 97.0%, and 96.0%, respectively.
  
  
  CONCLUSIONS
  When using US-guided FNA to diagnose salivary gland lesions, sampling adequacy depends on the composition or vascularity of the lesions.
authors.affiliation: Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Min Woo
authors.initials: MW
authors.lastname: Kim
authors.affiliation: Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea dwultra@lycos.co.kr.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Jung
authors.affiliation: Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Choo
authors.affiliation: Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Park
authors.affiliation: Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Jung
authors.affiliation: Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon, Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Baek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012469:Salivary Glands / Q000000981:diagnostic imaging / Q000473:pathology; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional / Q000379:methods*; D055815:Young Adult
keywords: fine-needle aspiration; head and neck ultrasound; malignancy; outcome; salivary gland; ultrasound