title: Nanoparticles and radiotracers: advances toward radionanomedicine.
abstract: In this study, we cover the convergence of radiochemistry for imaging and therapy with advances in nanoparticle (NP) design for biomedical applications. We first explore NP properties relevant for therapy and theranostics and emphasize the need for biocompatibility. We then explore radionuclide-imaging modalities such as positron emission tomography (PET), single-photon emission computed tomography (SPECT), and Cerenkov luminescence (CL) with examples utilizing radiolabeled NP for imaging. PET and SPECT have served as diagnostic workhorses in the clinic, while preclinical NP design examples of multimodal imaging with radiotracers show promise in imaging and therapy. CL expands the types of radionuclides beyond PET and SPECT tracers to include high-energy electrons (β-) for imaging purposes. These advances in radionanomedicine will be discussed, showing the potential for radiolabeled NPs as theranostic agents. WIREs Nanomed Nanobiotechnol 2016, 8:872-890. doi: 10.1002/wnan.1402 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Edwin C
authors.initials: EC
authors.lastname: Pratt
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.|Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.|Department of Chemistry, Hunter College and Graduate Center of the City University of New York, New York, NY, USA.
authors.forename: Travis M
authors.initials: TM
authors.lastname: Shaffer
authors.affiliation: Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA. grimmj@mskcc.org.|Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. grimmj@mskcc.org.|Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. grimmj@mskcc.org.|Department of Radiology, Weill Cornell Medical College, New York, NY, USA. grimmj@mskcc.org.
authors.forename: Jan
authors.initials: J
authors.lastname: Grimm
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D000068936:Theranostic Nanomedicine; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals