title: Label-free fluorescence detection of microRNA based on target induced adenosine2-coralyne-adenosine2 formation.
abstract: This study develops a simple and label-free biosensor for sensitive and selective detection of microRNA (miRNA) based on the formation of the adenosine2-coralyne-adenosine2 complex mediated by miRNA-specific polyadenosine extension.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. rqyu@hnu.edu.cn jianhuijiang@hnu.edu.cn.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xi
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Du
authors.forename: Ru-Qin
authors.initials: RQ
authors.lastname: Yu
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Jiang
mesh_terms: D000241:Adenosine / Q000737:chemistry*; D001600:Berberine Alkaloids / Q000737:chemistry*; D015374:Biosensing Techniques / Q000379:methods*; D035683:MicroRNAs / Q000032:analysis* / Q000737:chemistry; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011108:Polymers / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D001600:Berberine Alkaloids; D035683:MicroRNAs; D011108:Polymers; C069424:polyadenosine; C000666:coralyne; D000241:Adenosine