title: The interplay of post-translational modification and gene therapy.
abstract: Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on whether histone marks are read, added, or removed, respectively, from a specific amino acid. Transcription is controlled by dynamic epigenetic marks with serious health implications in certain complex diseases, whose understanding may be useful in gene therapy. This work highlights traditional and current advances in post-translational modifications with relevance to gene therapy delivery. We report that enhanced understanding of epigenetic machinery provides clues to functional implication of certain genes/gene products and may facilitate transition toward revision of our clinical treatment procedure with effective fortification of gene therapy delivery.
authors.affiliation: Covenant University Bioinformatics Research (CUBRe) Unit, Department of Computer and Information Sciences, College of Science and Technology (CST), Covenant University, Ota, Ogun State, Nigeria; Institute of Informatics (Computational biology and Bioinformatics), Faculty of Mathematics, Informatics and Mechanics, University of Warsaw (Uniwersytet Warszawski), Warszawa, Poland; Covenant University Public Health and Well-being Research Group (CUPHWERG), Covenant University, Canaan Land, Nigeria.
authors.forename: Victor Chukwudi
authors.initials: VC
authors.lastname: Osamor
authors.affiliation: Covenant University Public Health and Well-being Research Group (CUPHWERG), Covenant University, Canaan Land, Nigeria; Biochemistry and Molecular Biology Unit, Department of Biological Sciences, College of Science and Technology, Covenant University, Canaan Land, Nigeria.
authors.forename: Shalom N
authors.initials: SN
authors.lastname: Chinedu
authors.affiliation: Covenant University Public Health and Well-being Research Group (CUPHWERG), Covenant University, Canaan Land, Nigeria; Department of Economics and Development Studies, Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Dominic E
authors.initials: DE
authors.lastname: Azuh
authors.affiliation: Covenant University Public Health and Well-being Research Group (CUPHWERG), Covenant University, Canaan Land, Nigeria; Biochemistry and Molecular Biology Unit, Department of Biological Sciences, College of Science and Technology, Covenant University, Canaan Land, Nigeria.
authors.forename: Emeka Joshua
authors.initials: EJ
authors.lastname: Iweala
authors.affiliation: Covenant University Public Health and Well-being Research Group (CUPHWERG), Covenant University, Canaan Land, Nigeria; Biochemistry and Molecular Biology Unit, Department of Biological Sciences, College of Science and Technology, Covenant University, Canaan Land, Nigeria.
authors.forename: Olubanke Olujoke
authors.initials: OO
authors.lastname: Ogunlana
mesh_terms: D044127:Epigenesis, Genetic / Q000235:genetics*; D015316:Genetic Therapy; D006657:Histones / Q000378:metabolism; D006801:Humans; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D006657:Histones; D011506:Proteins
keywords: epigenetics; gene therapy; histone; methylation; post-translational modification