title: Biomimetic strategies for engineering composite tissues.
abstract: The formation of multiple tissue types and their integration into composite tissue units presents a frontier challenge in regenerative engineering. Tissue-tissue synchrony is crucial in providing structural support for internal organs and enabling daily activities. This review highlights the state-of-the-art in composite tissue scaffold design, and explores how biomimicry can be strategically applied to avoid over-engineering the scaffold. Given the complexity of biological tissues, determining the most relevant parameters for recapitulating native structure-function relationships through strategic biomimicry will reduce the burden for clinical translation. It is anticipated that these exciting efforts in composite tissue engineering will enable integrative and functional repair of common soft tissue injuries and lay the foundation for total joint or limb regeneration.
authors.affiliation: Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States.
authors.forename: Nancy
authors.initials: N
authors.lastname: Lee
authors.affiliation: Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States; Division of Orthodontics, College of Dental Medicine, Columbia University, New York, NY 10032, United States.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Robinson
authors.affiliation: Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States. Electronic address: hhlu@columbia.edu.
authors.forename: Helen
authors.initials: H
authors.lastname: Lu
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods*; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*