title: The serotonin reuptake inhibitor citalopram suppresses activity in the neonatal rat barrel cortex in vivo.
abstract: Inhibition of serotonin uptake, which causes an increase in extracellular serotonin levels, disrupts the development of thalamocortical barrel maps in neonatal rodents. Previous in vitro studies have suggested that the disruptive effect of excessive serotonin on barrel map formation involves a depression at thalamocortical synapses. However, the effects of serotonin uptake inhibitors on the early thalamocortical activity patterns in the developing barrel cortex in vivo remain largely unknown. Here, using extracellular recordings of the local field potentials and multiple unit activity (MUA) we explored the effects of the selective serotonin reuptake inhibitor (SSRI) citalopram (10-20mg/kg, intraperitoneally) on sensory evoked activity in the barrel cortex of neonatal (postnatal days P2-5) rats in vivo. We show that administration of citalopram suppresses the amplitude and prolongs the delay of the sensory evoked potentials, reduces the power and frequency of the early gamma oscillations, and suppresses sensory evoked and spontaneous neuronal firing. In the adolescent P21-29 animals, citalopram affected neither sensory evoked nor spontaneous activity in barrel cortex. We suggest that suppression of the early thalamocortical activity patterns contributes to the disruption of the barrel map development caused by SSRIs and other conditions elevating extracellular serotonin levels.
authors.affiliation: Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
authors.forename: Dinara
authors.initials: D
authors.lastname: Akhmetshina
authors.affiliation: Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia; Department of Physiology, Kazan State Medical University, Kazan, Russia.
authors.forename: Andrei
authors.initials: A
authors.lastname: Zakharov
authors.affiliation: Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
authors.forename: Daria
authors.initials: D
authors.lastname: Vinokurova
authors.affiliation: Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
authors.forename: Azat
authors.initials: A
authors.lastname: Nasretdinov
authors.affiliation: Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia. Electronic address: gurvaleeva@kpfu.ru.
authors.forename: Guzel
authors.initials: G
authors.lastname: Valeeva
authors.affiliation: Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia; INMED-INSERM U901, Marseille, France; University Aix-Marseille II, Marseille, France.
authors.forename: Roustem
authors.initials: R
authors.lastname: Khazipov
mesh_terms: D000367:Age Factors; D000470:Alkaloids; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects; D015283:Citalopram / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013057:Spectrum Analysis; D013997:Time Factors
chemical_list: D000470:Alkaloids; D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors; C110131:Wilcox compound
keywords: Citalopram; Electroencephalogram; Neonate; Selective serotonin reuptake inhibitors; Serotonin; Somatosensory cortex