title: Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice.
abstract: Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were given hot spring water for 2 weeks. Mice were then administrated PO at a dose of 500 mg/kg. The results obtained showed that serum uric acid levels were significantly increased by the administration of PO. Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Radon inhalation activated anti-oxidative functions in the liver and kidney. These results suggest that radon inhalation inhibits PO-induced hyperuricemia by activating anti-oxidative functions, while hot spring water drinking may suppress PO-induced elevations in serum uric acid levels through the pharmacological effects of the chemical compositions dissolved in it.
authors.affiliation: Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama 700-8558, Japan.
authors.forename: Reo
authors.initials: R
authors.lastname: Etani
authors.affiliation: Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama 700-8558, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kataoka
authors.affiliation: Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama 700-8558, Japan.
authors.forename: Norie
authors.initials: N
authors.lastname: Kanzaki
authors.affiliation: Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakoda
authors.affiliation: Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698, Japan.
authors.forename: Yuu
authors.initials: Y
authors.lastname: Ishimori
authors.affiliation: Misasa Medical Center, Okayama University Hospital, 827 Yamada, Misasa-cho, Tohaku-gun, Totori 682-0192, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Mitsunobu
authors.affiliation: Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama 700-8558, Japan yamaoka@md.okayama-u.ac.jp.
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Yamaoka
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D060766:Drinking Water / Q000737:chemistry*; D045482:Hot Springs; D033461:Hyperuricemia / Q000188:drug therapy* / Q000201:enzymology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008813:Mice, Inbred ICR; D010094:Oxonic Acid; D011886:Radon / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D014867:Water / Q000008:administration & dosage*; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D060766:Drinking Water; D014867:Water; C489337:potassium oxonate; D010094:Oxonic Acid; D014969:Xanthine Oxidase; D011886:Radon
keywords: anti-oxidative functions; hot spring water drinking; hyperuricemia; radon inhalation