title: Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders.
abstract: Abnormalities in the integral components of bone, including bone matrix, bone mineral and bone cells, give rise to complex disturbances of skeletal development, growth and homeostasis. Non-specific drug delivery using high-dose systemic administration may decrease therapeutic efficacy of drugs and increase the risk of toxic effects in non-skeletal tissues, which remain clinical challenges in the treatment of skeletal disorders. Thus, targeted delivery systems are urgently needed to achieve higher drug delivery efficiency, improve therapeutic efficacy in the targeted cells/tissues, and minimize toxicities in non-targeted cells/tissues. In this review, we summarize recent progress in the application of different targeting moieties and nanoparticles for targeted drug delivery in skeletal disorders, and also discuss the advantages, challenges and perspectives in their clinical translation.
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. danglei_hkbu@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Dang
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. liujin_hkbu@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. fayebalaba@live.com.
authors.forename: Fangfei
authors.initials: F
authors.lastname: Li
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. luyaoben@126.com.
authors.forename: Luyao
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. lidefang@163.com.
authors.forename: Defang
authors.initials: D
authors.lastname: Li
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. borisguo@hkbu.edu.hk.
authors.forename: Baosheng
authors.initials: B
authors.lastname: Guo
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. hxj19@126.com.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: He
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. jiangfeng@nbu.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. liangchao512@163.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. liubiao_hkbu@163.com.
authors.forename: Biao
authors.initials: B
authors.lastname: Liu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. aatikshaikh@gmail.com.
authors.forename: Shaikh Atik
authors.initials: SA
authors.lastname: Badshah
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. hebinghb@gmail.com.
authors.forename: Bing
authors.initials: B
authors.lastname: He
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. ljaaa111@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. lv_cheng0816@163.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. aipinglu@hkbu.edu.hk.
authors.forename: Aiping
authors.initials: A
authors.lastname: Lu
authors.affiliation: Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. zhangge@hkbu.edu.hk.
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001847:Bone Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D050071:Bone Density Conservation Agents
keywords: nanoparticles; skeletal disorders; targeted delivery systems; targeting moieties