title: Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine.
abstract: Stem cell-based approaches offer great application potential in tissue engineering and regenerative medicine owing to their ability of sensing the microenvironment and respond accordingly (dynamic behavior). Recently, the combination of nanobiomaterials with stem cells has paved a great way for further exploration. Nanobiomaterials with engineered surfaces could mimic the native microenvironment to which the seeded stem cells could adhere and migrate. Surface functionalized nanobiomaterial-based scaffolds could then be used to regulate or control the cellular functions to culture stem cells and regenerate damaged tissues or organs. Therefore, controlling the interactions between nanobiomaterials and stem cells is a critical factor. However, surface functionalization or modification techniques has provided an alternative approach for tailoring the nanobiomaterials surface in accordance to the physiological surrounding of a living cells; thereby, enhancing the structural and functional properties of the engineered tissues and organs. Currently, there are a variety of methods and technologies available to modify the surface of biomaterials according to the specific cell or tissue properties to be regenerated. This review highlights the trends in surface modification techniques for nanobiomaterials and the biological relevance in stem cell-based tissue engineering and regenerative medicine. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:554-567, 2016.
authors.affiliation: Centre for Stem Cell Research (CSCR), A Unit of Institute for Stem Cell Biology and Regenerative Medicine-Bengaluru, Stem Cell Nanotechnology Lab, Christian Medical College Campus, Vellore, 632002, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Rana
authors.affiliation: Centre for Stem Cell Research (CSCR), A Unit of Institute for Stem Cell Biology and Regenerative Medicine-Bengaluru, Stem Cell Nanotechnology Lab, Christian Medical College Campus, Vellore, 632002, India.
authors.forename: Keerthana
authors.initials: K
authors.lastname: Ramasamy
authors.affiliation: Dept. of Nanoscience and Technology, Karunya University, Coimbatore, 641114, India.
authors.forename: Maria
authors.initials: M
authors.lastname: Leena
authors.affiliation: BioMAT'X, Facultad De Odontología, Universidad De Los Andes, Mons. Álvaro Del Portillo, Santiago, 12.455, Chile.|Centro De Investigación Biomédica (CIB), Facultad De Medicina, Universidad De Los Andes, Mons. Álvaro Del Portillo, Santiago, 12.455, Chile.
authors.forename: Constanza
authors.initials: C
authors.lastname: Jiménez
authors.affiliation: BioMAT'X, Facultad De Odontología, Universidad De Los Andes, Mons. Álvaro Del Portillo, Santiago, 12.455, Chile.|Plan De Mejoramiento Institucional (PMI) En Innovación-I+D+I, Universidad De Los Andes, Santiago, 12.455, Chile.
authors.forename: Javier
authors.initials: J
authors.lastname: Campos
authors.affiliation: BioMAT'X, Facultad De Odontología, Universidad De Los Andes, Mons. Álvaro Del Portillo, Santiago, 12.455, Chile.|Plan De Mejoramiento Institucional (PMI) En Innovación-I+D+I, Universidad De Los Andes, Santiago, 12.455, Chile.
authors.forename: Paula
authors.initials: P
authors.lastname: Ibarra
authors.affiliation: BioMAT'X, Facultad De Odontología, Universidad De Los Andes, Mons. Álvaro Del Portillo, Santiago, 12.455, Chile.|Plan De Mejoramiento Institucional (PMI) En Innovación-I+D+I, Universidad De Los Andes, Santiago, 12.455, Chile.
authors.forename: Ziyad S
authors.initials: ZS
authors.lastname: Haidar
authors.affiliation: Centre for Stem Cell Research (CSCR), A Unit of Institute for Stem Cell Biology and Regenerative Medicine-Bengaluru, Stem Cell Nanotechnology Lab, Christian Medical College Campus, Vellore, 632002, India.|WPI-Advanced Institute for Materials Research, Tohoku University, Sendai, 980-8577, Japan.
authors.forename: Murugan
authors.initials: M
authors.lastname: Ramalingam
mesh_terms: D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D044968:Regenerative Medicine; D013234:Stem Cells / Q000166:cytology*; D013499:Surface Properties; D046509:Tissue Culture Techniques; D023822:Tissue Engineering
keywords: microenvironment; nanobiomaterials; regenerative medicine; stem cells; surface functionalization; tissue engineering