title: Comparison of blood and urine nephrin levels in preeclampsia and intrauterine growth retardation.
abstract: OBJECTIVE
  To evaluate the relation between nephrin levels and preeclampsia severity by comparing serum and urine levels of nephrin in the severe and mild groups according to severity of associated intrauterine growth retardation (IUGR) development.
  
  
  METHODS
  A total of 150 patients who attended our ante-natal clinic (ANC) were included in this study. We had 5 groups; Group 1:30 patients with mild preeclampsia (MP) and normal fetal development (NFD), Group 2:30 patients with severe preeclampsia (SP) and NFD, Group 3: 30 patients with MP and IUGR, Group 4: 30 patients with SP and IUGR and Group 5: 30 volunteers who were normotensive and non-preeclamptic. We obtained both blood and urine samples for measuring nephrin levels.
  
  
  RESULTS
  Both serum and urine nephrin levels were significantly higher for the fourth group compared with all other groups (p<0.001). The levels of SP group with NFD were measured considerably higher than MP group out of IUGR and control group (p<0.001). Urine and serum nephrin levels with gestational age of delivery showed a negative correlation (r=-0.621, p<0.001) and also urine and serum nephrin levels with birth weight showed a negative correlation too (r=-0.655 p<0.001).
  
  
  CONCLUSIONS
  Both serum and urine nephrin levels correlated with the severity of preeclampsia and IUGR development.
authors.affiliation: Fatma Ozdemir, MD, Department of Obstetrics and Gynecology, Education and Research Hospital, Kayseri, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Ozdemir
authors.affiliation: Ahter Tanay Tayyar, MD, Department of Obstetrics and Gynecology, Private Erciyes Hospital, Kayseri, Turkey.
authors.forename: Ahter Tanay
authors.initials: AT
authors.lastname: Tayyar
authors.affiliation: Gokhan Acmaz, MD, Department of Obstetrics and Gynecology, Education and Research Hospital, Kayseri, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Acmaz
authors.affiliation: Huseyin Aksoy, MD, Department of Obstetrics and Gynecology, Military Hospital, Kayseri, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aksoy
authors.affiliation: Gozde Erturk, Department of Biostatistics, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Gozde
authors.initials: G
authors.lastname: Erturk
authors.affiliation: Dr. Sabahattin Muhtaroglu, Professor, Department of Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Muhtaroglu
authors.affiliation: Dr. Mehmet Tayyar Professor, Department of Obstetrics and Gynecology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tayyar
keywords: Intrauterine growth retardation; Preeclampsia; Serum Nephrin; Urine Nephrin