title: Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization.
abstract: Caveolin-1 is a target for academic and pharmaceutical research due to its many cellular roles and associated diseases. We report peptide WL47 (1), a small, high-affinity, selective disrupter of caveolin-1 oligomers. Developed and optimized through screening and analysis of synthetic peptide libraries, ligand 1 has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. Ligand 1 will permit targeted study of caveolin-1 function.
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Amanda J H
authors.initials: AJ
authors.lastname: Gilliam
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Smith
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Dylan
authors.initials: D
authors.lastname: Flather
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Johnston
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Gansmiller
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Fishman
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Edgar
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Balk
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Majumdar
authors.affiliation: Department of Chemistry, and ‡Department of Molecular Biology and Biochemistry, University of California , Irvine, California 92697-2025, United States.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Weiss
mesh_terms: D001704:Biopolymers / Q000378:metabolism*; D051242:Caveolin 1 / Q000378:metabolism*; D008024:Ligands
chemical_list: D001704:Biopolymers; D051242:Caveolin 1; D008024:Ligands