title: Latex carrier for improving protoporphyrin IX for photodynamic therapy.
abstract: Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.
authors.affiliation: Nano-Biophysics Lab, Department of Physics, University of Texas at Arlington, TX 76019, USA. Electronic address: brqbui@gmail.com.
authors.forename: Brian
authors.initials: B
authors.lastname: Bui
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Nano-Biophysics Lab, Department of Physics, University of Texas at Arlington, TX 76019, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D004355:Drug Stability; D006801:Humans; D006860:Hydrogen Bonding; D007840:Latex / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods; D011471:Prostatic Neoplasms / Q000628:therapy*; D011524:Protoporphyrins / Q000737:chemistry*; D026082:Singlet Oxygen / Q000032:analysis; D012995:Solubility
chemical_list: D007840:Latex; D011524:Protoporphyrins; D026082:Singlet Oxygen; C028025:protoporphyrin IX
keywords: Latex carrier; Photodynamic therapy (PDT); Protoporphyrin (PPIX)