title: Clinical Next Generation Sequencing for Precision Medicine in Cancer.
abstract: Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput sequencing and rapid advances in our understanding of the genetic bases of human diseases. Today, the NGS method has dominated sequencing space in genomic research, and quickly entered clinical practice. Because unique features of NGS perfectly meet the clinical reality (need to do more with less), the NGS technology is becoming a driving force to realize the dream of precision medicine. This article describes the strengths of NGS, NGS panels used in precision medicine, current applications of NGS in cytology, and its challenges and future directions for routine clinical use.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 650 Charles Young Dr., Los Angeles, CA 90095, USA;
authors.forename: Ling
authors.initials: L
authors.lastname: Dong
authors.affiliation: Shanxi Guoxin Caregeno Medical Laboratories (MedLab), 7 Jiahua St., Taiyuan, Shanxi Province, China 030006;
authors.forename: Wanheng
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 650 Charles Young Dr., Los Angeles, CA 90095, USA;
authors.forename: Alvin
authors.initials: A
authors.lastname: Li
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 650 Charles Young Dr., Los Angeles, CA 90095, USA;
authors.forename: Rina
authors.initials: R
authors.lastname: Kansal
authors.affiliation: Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Harbin, China 150040.
authors.forename: Yuhan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Qiqihaer First Hospital, No.30, Gongyuan Road, Qiqihar, Heilongjiang Province, China 161005;
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 650 Charles Young Dr., Los Angeles, CA 90095, USA;
authors.forename: Xinmin
authors.initials: X
authors.lastname: Li
keywords: Cancer.; Gene panel; Next generation sequencing; Precision medicine; Whole exome sequencing