title: Enantioselective bromocyclization of 2-geranylphenols induced by chiral phosphite-urea bifunctional catalysts.
abstract: Chiral phosphite-urea bifunctional catalysts have been developed for the enantioselective bromocyclization of 2-geranylphenols with N-bromophthalimide (NBP) for the first time. The chiral triaryl phosphite moiety activates NBP to generate a bromophosphonium ion. On the other hand, the urea moiety interacts with a hydroxyl group of the substrate through hydrogen bonding interactions. Enantioselectivity is effectively induced through two-point attractive interactions between the catalyst and the substrate.
authors.affiliation: Graduate School of Engineering, Nagoya University, B2-3(611), Furo-cho, Chikusa, Nagoya 464-8603, Japan. ishihara@cc.nagoya-u.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sawamura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ogura
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Nakatsuji
authors.forename: Akira
authors.initials: A
authors.lastname: Sakakura
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara