title: Investigating the Extremes of Antibiotic Use with an Epidemiologic Framework.
abstract: Benchmarks for judicious use of antimicrobials are needed. Metrics such as defined daily doses (DDDs) and days of therapy (DOTs) quantify antimicrobial consumption. However, benchmarking with these metrics is complicated by interhospital variability. Thus, it is important for each hospital to monitor its own temporal consumption trends. Time series analyses allow trends to be detected; however, many of these methods are complex. We present simple regressive methods and caveats in using them to define potential antibiotic over- and underutilizations.
authors.affiliation: Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA mschee@midwestern.edu.
authors.forename: Marc H
authors.identifier: 0000-0002-1091-6130
authors.initials: MH
authors.lastname: Scheetz
authors.affiliation: Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA.
authors.forename: Page E
authors.initials: PE
authors.lastname: Crew
authors.affiliation: Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA.
authors.forename: Cristina
authors.initials: C
authors.lastname: Miglis
authors.affiliation: Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA Department of Pharmacy Practice, Chicago State University College of Pharmacy, Chicago, Illinois, USA.
authors.forename: Elise M
authors.initials: EM
authors.lastname: Gilbert
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Sutton
authors.affiliation: Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA.
authors.forename: J Nick
authors.initials: JN
authors.lastname: O'Donnell
authors.affiliation: Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Postelnick
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Teresa
authors.initials: T
authors.lastname: Zembower
authors.affiliation: Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA.
authors.forename: Nathaniel J
authors.identifier: 0000-0002-0018-5434
authors.initials: NJ
authors.lastname: Rhodes
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004363:Drug Utilization / Q000706:statistics & numerical data*; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents