title: Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment.
abstract: Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.
authors.affiliation: Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine.
authors.forename: M A
authors.initials: MA
authors.lastname: Stashkevich
authors.affiliation: Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine.
authors.forename: E V
authors.initials: EV
authors.lastname: Khomutov
authors.affiliation: Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Dumanskii
authors.affiliation: Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine. matviyenko.marina@gmail.com.
authors.forename: A G
authors.initials: AG
authors.lastname: Matvienko
authors.affiliation: Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine.
authors.forename: I I
authors.initials: II
authors.lastname: Zinkovich
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013939:Thymidine Phosphorylase / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D013939:Thymidine Phosphorylase; D005472:Fluorouracil
keywords: 5-fluorouracil; liver; rats; thymidine phosphorylase