title: CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects.
abstract: Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia. svetlana@mail.tomsknet.ru.|National Research Tomsk Polytechnical University, Tomsk, Russia. svetlana@mail.tomsknet.ru.
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
authors.affiliation: Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Vyalova
authors.affiliation: Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Voronina
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Pozhidaev
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Osmanova
authors.affiliation: St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ivanov
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.|National Research Tomsk Polytechnical University, Tomsk, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Fedorenko
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Semke
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Bokhan
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D000068079:Motor Disorders / Q000139:chemically induced* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy*; D000071057:Tardive Dyskinesia / Q000139:chemically induced* / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents; D019388:Cytochrome P-450 CYP1A2; D019389:Cytochrome P-450 CYP2D6
keywords: Cytochromes; gene polymorphism; hyperprolactinemia; schizophrenia; tardive dyskinesia