title: Association of the chromosome 11p13.5 variant and atopic dermatitis with a family history of atopy in the Chinese Han population.
abstract: BACKGROUND
  Recent genome-wide association studies (GWAS) and a meta-analysis of GWAS for atopic dermatitis (AD) have identified some AD genetic loci in European and Japanese populations.
  
  
  OBJECTIVE
  To investigate whether some novel susceptibility loci are associated with AD in the Chinese Han population.
  
  
  METHODS
  We first selected eight novel susceptibility loci to replicate in 2,205 AD patients and 2,116 healthy controls using the Sequenom platform. Data were analyzed with PLINK 1.07 software.
  
  
  RESULTS
  We found that rs12634229 (3q13.2), rs7927894 (11p13.5) and rs878860 (11p15.4) showed a slight association with AD (P = 0.012, P = 0.033, P = 0.020, respectively); rs6780220 (3p21.33) was preferentially related to AD with keratosis pilaris, but did not reach the threshold of significance after correction. The frequency of rs7927894 allele T was significantly different between AD patients with a positive and negative family history of atopy.
  
  
  CONCLUSIONS
  The loci rs7927894 (11p13.5) are related to AD with a positive family history of atopy in Chinese Han population, providing novel insight into the genetic pathogenesis of AD.
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Cheng
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Zhao
authors.forename: Xian-Fa
authors.initials: XF
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Cheng
authors.forename: Yu-Jun
authors.initials: YJ
authors.lastname: Sheng
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Jiang
authors.forename: Ling
authors.initials: L
authors.lastname: Fang
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Zhang
authors.forename: Xian-Bo
authors.initials: XB
authors.lastname: Zuo
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zheng
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: Zhou
authors.forename: Hua-Yang
authors.initials: HY
authors.lastname: Tang
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Feng-Li
authors.initials: FL
authors.lastname: Xiao
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D002880:Chromosomes, Human, Pair 11; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult