title: Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility-weighted imaging in idiopathic rapid eye movement sleep behavior disorder.
abstract: We assessed loss of dorsolateral nigral hyperintensity (DNH) on high-field susceptibility-weighted imaging (SWI), a novel magnetic resonance imaging marker for Parkinson's disease (PD), in 15 subjects with idiopathic rapid eye movement sleep behavior disorder (iRBD) and compared findings to 42 healthy controls (HCs) and 104 PD patients. We found loss of DNH in at least two thirds of iRBD subjects, which approaches the rate observed in PD and is in contrast to findings in HCs. We propose that absence of DNH on high-field SWI could identify prodromal degenerative parkinsonism in iRBD. Ann Neurol 2016;79:1026-1030.
authors.affiliation: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Roberto
authors.initials: R
authors.lastname: De Marzi
authors.affiliation: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.|Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Klaus
authors.initials: K
authors.lastname: Seppi
authors.affiliation: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Birgit
authors.initials: B
authors.lastname: Högl
authors.affiliation: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Müller
authors.affiliation: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.|Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Scherfler
authors.affiliation: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Ambra
authors.initials: A
authors.lastname: Stefani
authors.affiliation: Neurology Service, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
authors.forename: Alex
authors.initials: A
authors.lastname: Iranzo
authors.affiliation: Neurology Service, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tolosa
authors.affiliation: Neurology Service, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Santamarìa
authors.affiliation: Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.|Department of Radiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Elke
authors.initials: E
authors.lastname: Gizewski
authors.affiliation: Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.|Department of Radiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Schocke
authors.affiliation: Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.|Department of Radiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Skalla
authors.affiliation: Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.|Department of Radiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Kremser
authors.affiliation: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.|Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D010300:Parkinson Disease / Q000473:pathology; D062706:Prodromal Symptoms; D020187:REM Sleep Behavior Disorder / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology*