title: Lissencephaly in an adult Australian Kelpie.
abstract: METHODS
  A 6-year-old neutered male Australian Kelpie presented with a 2-year history of seizures. Neurological examination was consistent with a generalised prosencephalic lesion. Serum biochemical testing was performed in addition to magnetic resonance imaging of the brain and cerebrospinal fluid analysis. Magnetic resonance imaging revealed a reduction in the number of sulci and gyri in addition to cortical thickening, resulting in a diagnosis of lissencephaly. The dog was treated with anticonvulsants and follow-up information obtained from the referring veterinarian 11 months after diagnosis indicated that the dog had good seizure control.
  
  
  CONCLUSIONS
  This is the first report of lissencephaly in the Australian Kelpie and would suggest that some dogs with the condition can be managed with long-term anticonvulsant medication.
authors.affiliation: Translational Research and Animal Clinical Trial Study (TRACTS) Group, Section of Veterinary Neurology and Neurosurgery, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Highway, Werribee, Victoria, 3030, Australia. anne.fraser@unimelb.edu.au.
authors.forename: A R
authors.initials: AR
authors.lastname: Fraser
authors.affiliation: Translational Research and Animal Clinical Trial Study (TRACTS) Group, Section of Veterinary Neurology and Neurosurgery, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Highway, Werribee, Victoria, 3030, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: le Chevoir
authors.affiliation: Translational Research and Animal Clinical Trial Study (TRACTS) Group, Section of Veterinary Neurology and Neurosurgery, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Highway, Werribee, Victoria, 3030, Australia.
authors.forename: S N
authors.initials: SN
authors.lastname: Long
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000473:pathology; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D004285:Dogs; D054082:Lissencephaly / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D028321:Plant Preparations / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*
chemical_list: D000927:Anticonvulsants; D028321:Plant Preparations; D010634:Phenobarbital
keywords: dogs; lissencephaly; neuronal migration disorder; seizures