title: Influence of initial angiotensin receptor blockers on treatment persistence in uncomplicated hypertension: A nation-wide population-based study.
abstract: We identified 55 504 uncomplicated, treatment-naïve hypertensive patients who started angiotensin II receptor blockers (ARBs) in 2012 from national claims data. The proportion of patients remaining on any hypertension treatment at 12 months and the adherence rate were similar between the losartan cohort (66.82% and 68.25%) and the nonlosartan ARB cohort (67.48% and 69.01%). After adjusting for confounding factors, there was no difference in persistence (aHR 0.98, 95% confidence interval (CI) 0.95-1.01) on hypertension treatment between losartan and nonlosartan ARB cohort. Post hoc analysis showed that patients initially prescribed eprosartan, irbesartan (both, aHR 1.33), and telmisartan (aHR 1.11) were more likely to discontinue the initial drug, whereas valsartan initiators (aHR 0.96) were less likely compared with losartan initiators.
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology , Hanyang University , Gyeonggi-do , Republic of Korea.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Ah
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology , Hanyang University , Gyeonggi-do , Republic of Korea.
authors.forename: Ju-Yeun
authors.initials: JY
authors.lastname: Lee
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology , Hanyang University , Gyeonggi-do , Republic of Korea.
authors.forename: Yun-Jung
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: b College of Pharmacy & Research Institute of Pharmaceutical Sciences , Seoul National University , Seoul , Republic of Korea.
authors.forename: Jisun
authors.initials: J
authors.lastname: Kong
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology , Hanyang University , Gyeonggi-do , Republic of Korea.
authors.forename: Baegeum
authors.initials: B
authors.lastname: Kim
authors.affiliation: c College of Pharmacy , Sunchon National University , Suncheon , Jeollanam-do , Republic of Korea.
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Choi
authors.affiliation: b College of Pharmacy & Research Institute of Pharmaceutical Sciences , Seoul National University , Seoul , Republic of Korea.
authors.forename: Nayoung
authors.initials: N
authors.lastname: Han
authors.affiliation: b College of Pharmacy & Research Institute of Pharmaceutical Sciences , Seoul National University , Seoul , Republic of Korea.
authors.forename: Yun Mi
authors.initials: YM
authors.lastname: Yu
authors.affiliation: b College of Pharmacy & Research Institute of Pharmaceutical Sciences , Seoul National University , Seoul , Republic of Korea.
authors.forename: Jung Mi
authors.initials: JM
authors.lastname: Oh
authors.affiliation: b College of Pharmacy & Research Institute of Pharmaceutical Sciences , Seoul National University , Seoul , Republic of Korea.
authors.forename: Wan Gyoon
authors.initials: WG
authors.lastname: Shin
authors.affiliation: d Department of Internal Medicine , Seoul National University Hospital , Seoul , Republic of Korea.
authors.forename: Hae-Young
authors.initials: HY
authors.lastname: Lee
mesh_terms: D000179:Acrylates / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D001713:Biphenyl Compounds / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D007093:Imidazoles / Q000627:therapeutic use*; D000077405:Irbesartan; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013777:Tetrazoles / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*; D000068756:Valsartan / Q000627:therapeutic use*; D016903:Drug Monitoring
chemical_list: D000179:Acrylates; D057911:Angiotensin Receptor Antagonists; D001713:Biphenyl Compounds; D007093:Imidazoles; D013777:Tetrazoles; D013876:Thiophenes; C068373:eprosartan; D000068756:Valsartan; D000077405:Irbesartan; D019808:Losartan
keywords: Adherence; angiotensin-receptor blocker; hypertension; losartan; persistence