title: The pharmacological management of psychiatric comorbidities in patients with epilepsy.
abstract: Psychiatric disorders represent a frequent comorbidity in patients with epilepsy affecting quality of life, morbidity and mortality. Evidence-based data on the management of these conditions are limited but a number of recommendations are now available to guide clinical practice. The present paper reviews the pharmacological treatment of psychiatric problems in epilepsy with special attention to data coming from randomised controlled trials (RCTs), pharmacological interactions with AEDs and the issue of seizure worsening during treatment with psychotropic drugs. Epidemiologically or clinically relevant psychiatric conditions are discussed namely mood and anxiety disorders, psychoses and attention deficit hyperactivity disorder.
authors.affiliation: Atkinson Morley Regional Neuroscience Centre, St. George⿿s University Hospitals NHS Foundation Trust, London, United Kingdom; South West London & St. George⿿s Mental Health Trust, London, United Kingdom; Institute of Medical and Biomedical Sciences, St. George⿿s University of London, United Kingdom. Electronic address: mmula@sgul.ac.uk.
authors.forename: Marco
authors.initials: M
authors.lastname: Mula
mesh_terms: D000818:Animals; D015897:Comorbidity; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000453:epidemiology
keywords: Antidepressant drugs; Antiepileptic drugs; Antipsychotic drugs; Anxiety; Attention deficit hyperactivity disorder; Depression; Epilepsy; Interactions; Methylphenidate; Psychosis