title: Nanovectorization of DNA Through Cells Using Protamine Complexation.
abstract: Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.
authors.affiliation: Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.
authors.forename: Khaoula
authors.initials: K
authors.lastname: Boukari
authors.affiliation: Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Caoduro
authors.affiliation: Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.
authors.forename: Raoudha
authors.initials: R
authors.lastname: Kacem
authors.affiliation: Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Skandrani
authors.affiliation: Inserm 1098, EFS Bourgogne Franche Comté, University of Bourgogne Franche-Comté IFR133, Besancon, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Borg
authors.affiliation: Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.
authors.forename: Hatem
authors.initials: H
authors.lastname: Boulahdour
authors.affiliation: Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.
authors.forename: Tijani
authors.initials: T
authors.lastname: Gharbi
authors.affiliation: Université de Franche-Comté, Laboratoire de Biochimie, EA3922, Expression Génique et Pathologies du Système Nerveux Central, SFRIBCT FED 4234, UFR Sciences et Techniques, Besancon, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Delage-Mourroux
authors.affiliation: Université de Franche-Comté, Laboratoire de Biochimie, EA3922, Expression Génique et Pathologies du Système Nerveux Central, SFRIBCT FED 4234, UFR Sciences et Techniques, Besancon, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Hervouet
authors.affiliation: EA 4267 "Fonctions et Dysfonctions Epitheliales", Universite de Bourgogne Franche-Comte, UFR Sciences Medicales et Pharmaceutiques, 19 Rue Ambroise Pare, 25030, Besancon Cedex, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Pudlo
authors.affiliation: Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France. fabien.picaud@univ-fcomte.fr.
authors.forename: Fabien
authors.identifier: 0000-0002-0570-394X
authors.initials: F
authors.lastname: Picaud
mesh_terms: D000327:Adsorption; D000818:Animals; D001692:Biological Transport; D004247:DNA / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles / Q000737:chemistry; D037742:Nanotubes, Carbon; D010316:Particle Size; D011479:Protamines / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D011479:Protamines; D004247:DNA
keywords: Nanovectorization; Protamine; Simulation