title: In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and β-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice.
abstract: Increases in the risk of infections and malignancy due to immune suppressive therapies of inflammatory bowel diseases (IBDs) have led the researchers to focus on more nontoxic and acceptable natural products like curcumin. Here we investigate whether prophylactic and therapeutic application of the curcumin alters the enzyme activities of paraoxonase (PON), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and cytosolic β-glucosidase in dextran sulphate sodium (DSS)-induced ulcerative colitis mice. Prophylactic application of curcumin resulted in higher MPO activity, less body weight loss and longer colon lengths compared to therapeutic group indicating preventive role of curcumin in IBDs. DSS-induced decrease in liver and serum PON activities were completely recovered by prophylactic administration of curcumin. DSS-induced reduction in liver cytosolic β-glucosidase activity was not affected by curcumin neither in the prophylactic group nor in the therapeutic group. Erythrocyte CA activity was significantly increased in curcumin groups, however no remarkable change in G6PD activity was observed.
authors.affiliation: a Department of Molecular Biology and Genetics , Faculty of Science and Literature, Balikesir University , Balikesir , Turkey and.
authors.forename: Hatice
authors.initials: H
authors.lastname: Yildirim
authors.affiliation: b Department of Histology & Embryology , Medical Faculty, Balikesir University , Balikesir , Turkey.
authors.forename: Fatma Bahar
authors.initials: FB
authors.lastname: Sunay
authors.affiliation: a Department of Molecular Biology and Genetics , Faculty of Science and Literature, Balikesir University , Balikesir , Turkey and.
authors.forename: Selma
authors.initials: S
authors.lastname: Sinan
authors.affiliation: a Department of Molecular Biology and Genetics , Faculty of Science and Literature, Balikesir University , Balikesir , Turkey and.
authors.forename: Feray
authors.initials: F
authors.lastname: Köçkar
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000473:pathology; D003474:Curcumin / Q000627:therapeutic use*; D016264:Dextran Sulfate / Q000633:toxicity*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D001617:beta-Glucosidase / Q000378:metabolism*
chemical_list: D016264:Dextran Sulfate; D005954:Glucosephosphate Dehydrogenase; D043303:Aryldialkylphosphatase; D001617:beta-Glucosidase; D003474:Curcumin
keywords: Curcumin; enzyme; inflammatory bowel disease; ulcerative colitis