title: Revascularization with percutaneous coronary intervention does not affect androgen status in males with chronic stable angina pectoris.
abstract: There is a clear association between low serum testosterone and coronary artery disease (CAD) in men. Hypotestosteronaemia is associated with accelerated atherosclerosis and a quarter of men with CAD are biochemically hypogonadal. Amongst those with CAD, hypotestosteronaemia is associated with increased mortality. Testosterone vasodilates coronary arteries, and exogenous testosterone reduces ischaemia. Whether hypotestosteronaemia is a cause or a consequence of CAD remains unanswered. The aim of this prospective observational study was to investigate whether coronary revascularization affected androgen status in men with stable angina pectoris. Twenty five men (mean age 62.7, SD 9.18) with angiographically significant CAD and symptomatic angina underwent full coronary revascularization by percutaneous coronary intervention. Androgen status and symptoms of angina, stress, depression and sexual function were assessed before, and at one and 6 months after the coronary revascularization. All patients underwent complete revascularization which was associated with a significant reduction in angina symptoms and ischaemia. No significant difference was seen in total testosterone (11.33 nmol/L baseline; 12.56, 1 month post; 13.04 at 6 months; p = 0.08). A significant and sustained rise in sex hormone-binding globulin was seen (33.99 nm/L baseline; 36.11 nm/L 1 month post PCI; 37.94 nm/L at 6 months; p = 0.03) Overall, there was no significant alteration in any other marker of androgen status including free testosterone or bioavailable testosterone. There was no change in symptoms of anxiety, depression or sexual function. Coronary revascularization has no sustained effect on androgen status. This supports the hypothesis that hypotestosteronaemia is not a consequence of angina pectoris or myocardial ischaemia.
authors.affiliation: South Yorkshire Cardiothoracic Centre, Northern General Hospital, Sheffield, UK.|Department of Cardiovascular Science, University of Sheffield, Sheffield, UK.
authors.forename: J N
authors.initials: JN
authors.lastname: Gosai
authors.affiliation: South Yorkshire Cardiothoracic Centre, Northern General Hospital, Sheffield, UK.
authors.forename: P
authors.initials: P
authors.lastname: Charalampidis
authors.affiliation: South Yorkshire Cardiothoracic Centre, Northern General Hospital, Sheffield, UK.
authors.forename: T
authors.initials: T
authors.lastname: Nikolaidou
authors.affiliation: South Yorkshire Cardiothoracic Centre, Northern General Hospital, Sheffield, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Parviz
authors.affiliation: South Yorkshire Cardiothoracic Centre, Northern General Hospital, Sheffield, UK.|Department of Cardiovascular Science, University of Sheffield, Sheffield, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Morris
authors.affiliation: Sheffield Hallam University, Sheffield, UK.
authors.forename: K S
authors.initials: KS
authors.lastname: Channer
authors.affiliation: Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK.|Department of Human Metabolism, University of Sheffield, Sheffield, UK.
authors.forename: T H
authors.initials: TH
authors.lastname: Jones
authors.affiliation: South Yorkshire Cardiothoracic Centre, Northern General Hospital, Sheffield, UK.
authors.forename: E D
authors.initials: ED
authors.lastname: Grech
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000601:surgery*; D003863:Depression / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013315:Stress, Psychological / Q000097:blood / Q000175:diagnosis; D013739:Testosterone / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone
keywords: angina; biomarkers; coronary artery disease; testosterone