title: Hypertension: the missing WNKs.
abstract: The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes but also how mutations in WNKs and their interacting partners contribute to hypertensive disorders. Defining the roles of WNKs in the cardiovascular system will provide clues about additional mechanisms by which WNKs can regulate blood pressure. This review summarizes recent developments in the regulation of the WNK signaling cascade and its role in regulation of blood pressure.
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Hashem A
authors.initials: HA
authors.lastname: Dbouk
authors.affiliation: Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Chou-Long
authors.initials: CL
authors.lastname: Huang
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and Melanie.cobb@utsouthwestern.edu.
authors.forename: Melanie H
authors.initials: MH
authors.lastname: Cobb
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases
keywords: WNK; cardiovascular; hypertension