title: Association between histopathological subtype,18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma.
abstract: The aim of the present study was to investigate the association between histopathological subtypes, epidermal growth factor receptor (EGFR) mutations and18F-fluorodeoxyglucose (FDG) uptake in patients with lung adenocarcinoma (ADC). The cases of 97 patients with lung ADC who underwent18F-FDG positron emission tomography-computed tomography prior to surgical resection were retrospectively reviewed. The patients were stratified according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification, and graded using a histopathological scoring system. EGFR mutations were identified. Clinicopathological characteristics associated with EGFR mutation status were evaluated using univariate and multivariate analyses. EGFR mutation was identified in 45.4% of the patients and was associated with gender, smoking history, maximum standardized uptake value (SUVmax) and histopathological score. ADC patients with a low SUVmax were more likely to exhibit EGFR mutations compared with patients with a high SUVmax (P=0.018). Patients with a lower histopathological score possessed a significantly lower SUVmax compared with patients with a higher score (P<0.001). Furthermore, the histopathological score and smoking history of the patients were identified to be independent predictors for EGFR mutations, according to multivariate logistic regression analysis. In conclusion, SUVmax and EGFR mutations were associated with lung ADC patients stratified according to the IASLC/ATS/ERS classification. Overall, SUVmax has the potential to be a useful marker in stratifying pre-operative patients with lung ADC and identifying EGFR mutations.
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Qiang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Jue
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Y E
authors.initials: YE
authors.lastname: Wang
authors.affiliation: Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Jiping
authors.initials: J
authors.lastname: DA
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
authors.forename: Deruo
authors.initials: D
authors.lastname: Liu
keywords: adenocarcinoma; epidermal growth factor receptor; histological subtype; maximum standardized uptake value