title: Neuron-specific enolase levels in drug-naïve young adults with major depressive disorder.
abstract: The aim of this study is to assess neuron-specific enolase (NSE) levels and clinical features in subjects with major depressive disorder (MDD). This is a cross-sectional study with drug-naïve young adults with MDD (aged 18-29 years). Serum levels of NSE were assessed using the electrochemiluminescence method. MDD diagnosis, suicidal ideation, and time of disease were assessed using the Structured Clinical Interview for DSM-IV (SCID). The Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) were used to assess depressive and anxiety symptoms. No relationship was observed between NSE levels and severity of depressive and anxiety symptoms, time of disease, and suicidal ideation. These results suggest that NSE serum levels were not associated with clinical features of MDD among drug-naïve young adults.
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil; Hospital São Francisco de Paula, Universidade Católica de Pelotas, Pelotas, Brazil. Electronic address: carolinawiener@gmail.com.
authors.forename: Carolina David
authors.initials: CD
authors.lastname: Wiener
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Mariane Lopez
authors.initials: ML
authors.lastname: Molina
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Miguel
authors.initials: M
authors.lastname: Passos
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Fernanda Pedrotti
authors.initials: FP
authors.lastname: Moreira
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Bittencourt
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Luciano Dias
authors.initials: LD
authors.lastname: de Mattos Souza
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Ricardo Azevedo
authors.initials: RA
authors.lastname: da Silva
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Karen
authors.initials: K
authors.lastname: Jansen
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil; Hospital São Francisco de Paula, Universidade Católica de Pelotas, Pelotas, Brazil.
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Oses
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000201:enzymology / Q000523:psychology; D003430:Cross-Sectional Studies; D003863:Depression / Q000201:enzymology / Q000523:psychology; D003865:Major Depressive Disorder / Q000201:enzymology* / Q000523:psychology; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D059020:Suicidal Ideation; D055815:Young Adult
chemical_list: D010751:Phosphopyruvate Hydratase
keywords: Biological marker; Clinical features; Major depressive disorder; Neuron-specific enolase