title: Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS).
abstract: According to World Health Organization (WHO) estimates, cancer is responsible for more deaths than all coronary heart disease or stroke worldwide, serving as a major public health threat around the world. High resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS) has demonstrated its usefulness in the identification of cancer metabolic markers with the potential to improve diagnosis and prognosis for the oncology clinic, due partially to its ability to preserve tissue architecture for subsequent histological and molecular pathology analysis. Capable of the quantification of individual metabolites, ratios of metabolites, and entire metabolomic profiles, HRMAS MRS is one of the major techniques now used in cancer metabolomic research. This article reviews and discusses literature reports of HRMAS MRS studies of cancer metabolomics published between 2010 and 2015 according to anatomical origins, including brain, breast, prostate, lung, gastrointestinal, and neuroendocrine cancers. These studies focused on improving diagnosis and understanding patient prognostication, monitoring treatment effects, as well as correlating with the use of in vivo MRS in cancer clinics.
authors.affiliation: Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, CNY-6, Charlestown, MA 02129, USA. tfuss@mgh.harvard.edu.
authors.forename: Taylor L
authors.initials: TL
authors.lastname: Fuss
authors.affiliation: Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, CNY-6, Charlestown, MA 02129, USA. cheng@nmr.mgh.harvard.edu.
authors.forename: Leo L
authors.initials: LL
authors.lastname: Cheng
keywords: cancer; high-resolution magic angle spinning (HRMAS); magnetic resonance spectroscopy (MRS); metabolomics