title: Electrical source localization by LORETA in patients with epilepsy: Confirmation by postoperative MRI.
abstract: BACKGROUND
  Few studies have been conducted that have compared electrical source localization (ESL) results obtained by analyzing ictal patterns in scalp electroencephalogram (EEG) with the brain areas that are found to be responsible for seizures using other brain imaging techniques. Additionally, adequate studies have not been performed to confirm the accuracy of ESL methods.
  
  
  METHODS
  In this study, ESL was conducted using LORETA (Low Resolution Brain Electromagnetic Tomography) in 9 patients with lesions apparent on magnetic resonance imaging (MRI) and in 6 patients who did not exhibit lesions on their MRIs. EEGs of patients who underwent surgery for epilepsy and had follow-ups for at least 1 year after operations were analyzed for ictal spike, rhythmic, paroxysmal fast, and obscured EEG activities. Epileptogenic zones identified in postoperative MRIs were then compared with localizations obtained by LORETA model we employed.
  
  
  RESULTS
  We found that brain areas determined via ESL were in concordance with resected brain areas for 13 of the 15 patients evaluated, and those 13 patients were post-operatively determined as being seizure-free.
  
  
  CONCLUSIONS
  ESL, which is a noninvasive technique, may contribute to the correct delineation of epileptogenic zones in patients who will eventually undergo surgery to treat epilepsy, (regardless of neuroimaging status). Moreover, ESL may aid in deciding on the number and localization of intracranial electrodes to be used in patients who are candidates for invasive recording.
authors.affiliation: Department of Biophysics, Ankara Atatürk Training and Research Hospital, Yıldırım Beyazıt University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Gülsüm
authors.initials: G
authors.lastname: Akdeniz
keywords: Epilepsy; LORETA; epileptogenic zone; postoperative MRI; source localization