title: Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know.
abstract: Precision medicine is a rapidly evolving area in the treatment of gynecologic malignancies. Advances in sequencing technology have resulted in an increasing wealth of data regarding the genomic characteristics of ovarian, endometrial, and cervical cancers. These vast new datasets of information have led to novel insights into potential vulnerabilities and therapeutic targets for these cancers. However, unraveling the complex molecular changes within cancer cells to determine how best to attack these targets and to identify effective biomarkers of response remains a significant challenge. In this article, we review the current status of biomarker-driven targeted therapy in gynecologic malignancies.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.
authors.forename: Joyce
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: swestin@mdanderson.org.
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Westin
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D019398:Genes, BRCA1; D016158:Genes, p53; D005833:Genital Neoplasms, Female / Q000235:genetics / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D009154:Mutation; D000081082:Phosphoinositide-3 Kinase Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000627:therapeutic use; D057285:Precision Medicine; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D000081082:Phosphoinositide-3 Kinase Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: Biomarkers; Gynecologic cancer; Personalized medicine; Precision medicine; Targeted therapy