title: Studies of Influenza A/H1N1 A/Tomsk/13/2010 Virus Topology during Development of Infectious Process in Mammals.
abstract: Influenza A/H1N1 A/Tomsk/13/2010 virus registered in Siberia in 2010 proved to be an extremely pathogenic strain. Dynamic study of the topology of this influenza virus strain in the lungs, liver, kidneys, lymph nodes, and great vessels of infected mice was carried out. Influenza A virus was detected by immunohistochemical methods in cells of different histogenesis in all the studied organs throughout the observation period (days 1-30 postinfection), which indicated effective replication and long persistence of influenza A/H1N1 A/Tomsk/13/2010 virus in mammalian cells.
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Potapova
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia. anya.kovner@gmail.com.
authors.forename: A V
authors.initials: AV
authors.lastname: Kovner
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Anikina
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Cherdantseva
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Sharkova
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupy
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Vasil'eva
authors.affiliation: Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Shestopalov
mesh_terms: D000818:Animals; D053118:Influenza A Virus, H1N1 Subtype / Q000472:pathogenicity*; D007668:Kidney / Q000473:pathology / Q000821:virology*; D008168:Lung / Q000473:pathology / Q000821:virology*; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000821:virology; D012800:Siberia; D014779:Virus Replication
keywords: great vessels; influenza A/H1N1 A/Tomsk/13/2010 virus; liver; lungs; lymph nodes