title: [Study of teratogenicity of 2, 2-dinitroethene-1, 1-diamine in sprague dawley rats].
abstract: OBJECTIVE
  To detect the toxicity and teratogenicity of 2, 2-dinitroethene-1, 1-diamine (FOX-7) in rats.
  
  
  METHODS
  125 adult SD rats were randomly divided into five groups, which are negative control (0 mg/kg) , positive control (280 mg/kg aspirin) , and three dose groups (5, 15, and 45 mg/kg) . They were administrated by gavage once a day from the 5th days to 19th days after pregnancy. The weight changes and toxicity of pregnant rats are recorded within the study, and the skeleton and internal organs malformations are detected by the recommended methods.
  
  
  RESULTS
  After 5 or 6 days being poisoned, the pregnant rats appear significantly toxicity symptoms, such as exciting, irritability, and so on. The net weight raise in high dose group is less than the negative group, while the numbers of dead foetus in median and high dose groups are both more than that of negative group. Comparing with the negative group, the body weight and body lenghth of foetus rats in median and high dose groups, and the tail lenghth in high dose group are lower significantly. There are no external malformations in negative group and three dose groups. However, the foetus of high dose group appear significant skeleton and internal organs malformation prevalences that are significant more than negative group, including lateral cerebral ventricles enlarged, which accounts for 9.17%, occipital bone lost, which accounts for 2.59%.
  
  
  CONCLUSIONS
  FOX-7 can induced maternal reproductive toxicity, foetus toxicity and teratogenicity hazards to rats.
authors.affiliation: CNGC Institute of Industrial Health, Xi'an 710065, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Liu
authors.forename: Panhong
authors.initials: P
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Junhong
authors.initials: J
authors.lastname: Gao
authors.forename: Qin
authors.initials: Q
authors.lastname: Lu
authors.forename: Hong
authors.initials: H
authors.lastname: Yue
authors.forename: Jiefang
authors.initials: J
authors.lastname: Xia
mesh_terms: D000818:Animals; D001835:Body Weight; D005260:Female; D009574:Nitro Compounds / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013723:Teratogens / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: C533965:1,1-diamino-2,2-dinitroethene; D009574:Nitro Compounds; D013723:Teratogens