title: Acquired Multiple Cysts of the Kidney in Neuroblastoma Survivors.
abstract: Cystic kidney disease includes a wide range of hereditary, developmental, and acquired conditions of the kidneys. Some of the inherited causes of cystic kidney disease include autosomal dominant polycystic kidney diseases (caused by mutations in PKD1 or PKD2), autosomal recessive polycystic kidney disease, tuberous sclerosis complex, von Hippel-Lindau disease, oral-facial-digital syndrome type I, and Hadju-Cheney syndrome. Acquired cystic kidney disease has been reported in patients receiving long-term hemodialysis or peritoneal dialysis and in children after liver transplantation. Acute kidney injury can occur in patients with neuroblastoma, usually as a result of thrombotic microangiopathy associated with bone marrow transplantation. End-stage renal disease is described in long-term survivors. However, in this case report, we provide what is to our knowledge the first description of multiple kidney cysts in long-term survivors of stage IV neuroblastoma. None of the 7 patients we describe with neuroblastoma and multiple kidney cysts had a family history of autosomal dominant polycystic kidney disease. Also, all lacked stigmata of tuberous sclerosis complex, von Hippel-Lindau disease, or Hadju-Cheney syndrome. Two patients progressed to end-stage renal disease; in addition, one of them developed an oncocytoid renal cell carcinoma.
authors.affiliation: Division of Nephrology, Department of Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE. Electronic address: divya.moodalbail@nemours.org.
authors.forename: Divya G
authors.initials: DG
authors.lastname: Moodalbail
authors.affiliation: Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Leah Z
authors.initials: LZ
authors.lastname: Apple
authors.affiliation: Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Meyers
authors.affiliation: Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Jill P
authors.initials: JP
authors.lastname: Ginsberg
authors.affiliation: Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Bernard S
authors.initials: BS
authors.lastname: Kaplan
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Richard
authors.initials: R
authors.lastname: Bellah
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000209:etiology*; D007680:Kidney Neoplasms / Q000628:therapy; D008297:Male; D009447:Neuroblastoma / Q000628:therapy; D012189:Retrospective Studies; D017741:Survivors; D055815:Young Adult
keywords: Chronic kidney disease (CKD); acquired cystic kidney disease; case report; computed tomography; cystic kidney disease; magnetic resonance imaging; multiple renal cysts; neuroblastoma; ultrasound