title: Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective.
abstract: Impairment of the epithelial barrier function is closely linked to the pathogenesis of various gastrointestinal diseases, food allergies, type I diabetes, and other systematic diseases. Plant-derived polyphenols are natural secondary metabolites and exert various physiological benefits, including anti-inflammatory, anti-oxidative, anti-carcinogenic, and anti-aging effects. Recent studies also show the role of plant polyphenols in regulation of the intestinal barrier and prevention of intestinal inflammatory diseases. Here we summarize the regulatory pathways and mediators linking polyphenols to their beneficial effects on tight junction and gut epithelial barrier functions, and provide useful information about using polyphenols as nutraceuticals for intestinal diseases.
authors.affiliation: a School of Food Science , Washington State University , Pullman , Washington , USA.
authors.forename: Guan
authors.initials: G
authors.lastname: Yang
authors.affiliation: a School of Food Science , Washington State University , Pullman , Washington , USA.
authors.forename: Shima
authors.initials: S
authors.lastname: Bibi
authors.affiliation: b Department of Animal Science , Washington State University , Pullman , Washington , USA.
authors.forename: Min
authors.initials: M
authors.lastname: Du
authors.affiliation: c Department of Biofunctional Science and Technology , Hiroshima University , Higashi-Hiroshima , Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: a School of Food Science , Washington State University , Pullman , Washington , USA.
authors.forename: Mei-Jun
authors.initials: MJ
authors.lastname: Zhu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006801:Humans; D007410:Intestinal Diseases / Q000517:prevention & control*; D007413:Intestinal Mucosa; D007422:Intestines; D059808:Polyphenols / Q000494:pharmacology*; D019108:Tight Junctions / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D059808:Polyphenols
keywords: Polyphenols; barrier function; intestinal epithelium; signaling pathway; tight junction