title: New time-saving predictor algorithm for multiple breath washout in adolescents.
abstract: Multiple breath washout (MBW) is an informative but time-consuming test. This study evaluates the uncertainty of a time-saving predictor algorithm in adolescents.
  
  
  
  Adolescents were recruited from the Copenhagen Prospective Study on Asthma in Childhood (COPSAC2000) birth cohort. MBW trials were performed at 13 y of age with Innocor model Inn00400 using sulfur hexafluoride (SF6) as tracer gas. Measurements were analyzed using a mixed model focusing on two prediction points doubling (t5%) and quadrupling (t10%) the standard end point (t2.5%).
  
  
  
  One hundred and seventy-two MBW trials conducted in 78 adolescents with and without asthma from COPSAC2000 were included. At t10%, the washout time (WoT) was reduced by 41%, and an uncertainty of 0.159 lung clearance index (LCI) units was introduced (±2 SD), ±1.27). At t5%, the WoT was reduced by 25%, with an uncertainty of 0.083 LCI units (±0.558). The optimal prediction point, which led to most saved time and least uncertainty was t5%.
  
  
  
  The predictor algorithm is capable of shortening the MBW test time but introduces an increasing uncertainty with earlier prediction points. This first-of-a-kind prediction algorithm holds promise in shortening the MBW test in children but should be used with caution in subjects with normal LCI values.
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Grønbæk
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Henrik Wegener
authors.initials: HW
authors.lastname: Hallas
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lambang
authors.initials: L
authors.lastname: Arianto
authors.affiliation: Innovision ApS, Glamsbjerg, Denmark.
authors.forename: Knud
authors.initials: K
authors.lastname: Pedersen
authors.affiliation: Innovision ApS, Glamsbjerg, Denmark.
authors.forename: Arne
authors.initials: A
authors.lastname: Thomsen
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Bo Lund
authors.initials: BL
authors.lastname: Chawes
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Bisgaard
mesh_terms: D000293:Adolescent; D000295:Adolescent Medicine / Q000379:methods; D000465:Algorithms; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D001944:Breath Tests / Q000379:methods*; D045853:Exhalation; D005260:Female; D005541:Forced Expiratory Volume; D005740:Gases; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000502:physiology; D008297:Male; D011446:Prospective Studies; D015203:Reproducibility of Results; D012119:Respiration; D013459:Sulfur Hexafluoride / Q000737:chemistry; D013997:Time Factors
chemical_list: D005740:Gases; D013459:Sulfur Hexafluoride