title: Impact of Magnesium L-Lactate on Occurrence of Ventricular Arrhythmias in Patients with Implantable Cardioverter Defibrillators: A Randomized, Placebo-Controlled Trial.
abstract: BACKGROUND
  We evaluated the antiarrhythmic efficacy and quality of life (QoL) impact of oral magnesium Llactate on patients with an implantable cardioverter defibrillator (ICD).
  
  
  METHODS
  This prospective, double-blind, placebo-controlled trial randomized 70 patients with an ICD to receive oral magnesium L-lactate 3 tablets twice daily (504mg elemental magnesium daily) or matching placebo for 12 months. Patients were seen at baseline, 12, 24, 36, and 52 weeks. The primary endpoints were the cumulative occurrence of ICD therapy [either shock or anti-tachycardia pacing (ATP)] or QoL between the groups.
  
  
  RESULTS
  Among the 70 randomized patients with a mean ± SD follow-up of 6.4 ± 4.1 months, 10 patients in the placebo group and 8 in the magnesium group experienced either ICD shock or ATP [HR 0.84, 95% CI 0.33 to 2.12; p=0.706]. Without significant arrhythmia suppression, only minimal effects on QoL were seen. Eighty six percent of all patients had serum intracellular magnesium deficiency.
  
  
  CONCLUSIONS
  In our underpowered trial, patients with ICDs had intracellular magnesium deficiency but oral magnesium Llactate only nonsignificantly reduced the occurrence of ICD therapies and had little impact on HrQoL.
authors.affiliation: University of Connecticut, Schools of Pharmacy, Hartford CT, USA; Storrs and Farmington, Hartford Hospital, Division of Pharmacy, Hartford CT, USA.
authors.forename: William L
authors.initials: WL
authors.lastname: Baker
authors.affiliation: University of Connecticut, Schools of Medicine, Hhartford CT, USA; Storrs and Farmington, Hartford Hospital, Division of Cardiology, Hartford CT, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kluger
authors.affiliation: University of Connecticut, Schools of Pharmacy, Hartford CT, USA; Storrs and Farmington, Hartford Hospital, Division of Pharmacy, Hartford CT, USA.
authors.forename: Craig I
authors.initials: CI
authors.lastname: Coleman
authors.affiliation: University of Connecticut, Schools of Pharmacy, Hartford CT, USA; Storrs and Farmington, Hartford Hospital, Division of Pharmacy, Hartford CT, USA.
authors.forename: C Michael
authors.initials: CM
authors.lastname: White
keywords: Magnesium; arrhythmia; implantable cardioverter defibrillator; quality of life