title: iPSCs, a Future Tool for Therapeutic Intervention in Mitochondrial Disorders: Pros and Cons.
abstract: Mitochondrial disorders, although individually are rare, taken together constitute a big group of diseases that share a defect in the oxidative phosphorylation system. Up to now, the development of therapies for these diseases is very slow and ineffective due in part to the lack of appropriate disease models. Therefore, there is an urgent need for the discovery of new therapeutic interventions. Regarding this, the generation of induced pluripotent stem cells (iPSCs) has opened new expectations in the regenerative medicine field. However, special cares and considerations must be taken into account previous to a replacement therapy. J. Cell. Physiol. 231: 2317-2318, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.|Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC and Centro de Investigación Biomédica en Red (CIBERER), Madrid, Spain.|Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Galera
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.|Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC and Centro de Investigación Biomédica en Red (CIBERER), Madrid, Spain.|Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Zurita-Díaz
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.|Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC and Centro de Investigación Biomédica en Red (CIBERER), Madrid, Spain.|Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Garesse
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.|Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC and Centro de Investigación Biomédica en Red (CIBERER), Madrid, Spain.|Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.
authors.forename: M Esther
authors.initials: ME
authors.lastname: Gallardo
mesh_terms: D056915:DNA Copy Number Variations / Q000235:genetics; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation*; D028361:Mitochondrial Diseases / Q000235:genetics / Q000628:therapy*; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics