title: Fine-Needle Aspiration Biopsy in Orbital Lesions: A Retrospective Study of 225 Cases.
abstract: To describe and analyze results from the fine-needle aspiration biopsy (FNAB) technique, used as a diagnostic tool, in patients with orbital lesions.
  
  
  
  Retrospective case series.
  
  
  
  setting: Institutional (Karolinska Hospital, Stockholm).
  
  
  
  207 patients with 210 orbital lesions.
  
  
  
  225 FNABs of the orbit.
  
  
  
  Successful diagnosis from FNAB.
  
  
  
  Of the 210 orbital lesions evaluated with FNAB, a successful cytologic diagnosis was achieved in 176 (84%). In more than half of the orbital lesions (54%), the FNAB diagnosis in addition to imaging appearance, clinical appearance, and clinical history provided sufficient information for treatment, and the patient did not require an incisional or excisional biopsy. Ninety-seven patients underwent additional excisional or incisional biopsy; FNAB diagnoses and the histopathologic diagnoses corresponded in 87% of the cases with an intraclass correlation coefficient of 0.84 (95% confidence interval [CI] 0.76-0.90). The difference was statistically significant between the ability to make a successful cytologic FNAB diagnosis in palpable lesions vs nonpalpable lesions (successful diagnosis in 90% [CI = 85%-95%] vs 75% [CI = 66%-84%]; P < .01). Neither the orbital quadrant location, nor the radiologic appearance (diffuse vs encapsulated), nor size of the lesion affected the success of FNAB diagnoses (all P > .7). There was a complication in 6 cases (3%). All complications were temporary and none led to permanent damage.
  
  
  
  FNAB proved effective and exceedingly safe. With the current healthcare climate of minimally invasive surgery and cost control, FNAB should be considered as a valid alternative to open surgery in the evaluation and management of orbital lesions.
authors.affiliation: Department of Oculoplastic and Orbital Service, St Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anna C H
authors.initials: ACH
authors.lastname: Wiktorin
authors.affiliation: Department of Oculoplastic and Orbital Service, St Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Eva M E
authors.initials: EME
authors.lastname: Dafgård Kopp
authors.affiliation: Department of Pathology and Cytology, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden.
authors.forename: Edneia
authors.initials: E
authors.lastname: Tani
authors.affiliation: Department of Diagnostic Radiology, Karolinska University Hospital, Solna, Sweden.
authors.forename: Boel
authors.initials: B
authors.lastname: Söderén
authors.affiliation: Department of Oculoplastic and Orbital Service, St Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden. Electronic address: richardcutlerallen@gmail.com.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Allen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000473:pathology*; D009918:Orbital Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies