title: Effectiveness of influenza vaccination for preventing influenza-related complications in people with asthma: a systematic review protocol.
abstract: BACKGROUND
  Influenza vaccination is administered annually as a preventive measure against influenza infection and influenza-related complications in high-risk individuals, such as those with asthma. However, the effectiveness of influenza vaccination in people with asthma against influenza-related complications is still not well established.
  
  
  METHODS
  We will search the following databases: MEDLINE (Ovid), EMBASE (Ovid), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, Cochrane Database of Systematic Reviews (CDSR), Web of Science Core Collection, Science direct, WHO Library Information System (WHOLIS), Global Health Library and Chinese databases (CNKI, Wanfang and ChongQing VIP) from Jan 1970 to Jan 2016 for observational and experimental studies on effectiveness of influenza vaccine in people with asthma. The identification of studies will be complemented with the searching of the reference lists and citations, and contacting influenza vaccine manufacturers to identify unpublished or ongoing studies. Two reviewers will extract data and appraise the quality of each study independently. Separate meta-analyses will be undertaken for observational and experimental evidence using fixed-effect or random-effects models, as appropriate.
  
  
  BACKGROUND
  Formal ethical approval is not required, as primary data will not be collected. The review will be disseminated in peer-reviewed publications and conference presentations.
authors.affiliation: Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Teviot, Medical School, Edinburgh, UK.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Vasileiou
authors.affiliation: Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Teviot, Medical School, Edinburgh, UK.
authors.forename: Aziz
authors.initials: A
authors.lastname: Sheikh
authors.affiliation: Nuffield Department of Primary Care Health Sciences, Oxford University, New Radcliffe House, Radcliffe Observatory Quarter, Oxford, UK Cardiff University, Institute of Primary Care and Public Health, Cardiff, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Butler
authors.affiliation: Health Protection Scotland, NHS National Services Scotland, Meridian Court, Glasgow, UK.
authors.forename: Beatrix
authors.initials: B
authors.lastname: von Wissmann
authors.affiliation: Health Protection Scotland, NHS National Services Scotland, Meridian Court, Glasgow, UK.
authors.forename: Jim
authors.initials: J
authors.lastname: McMenamin
authors.affiliation: Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK.
authors.forename: Lewis
authors.initials: L
authors.lastname: Ritchie
authors.affiliation: The University of Edinburgh, Teviot, Medical School, Edinburgh, UK.
authors.forename: Lilly
authors.initials: L
authors.lastname: Tian
authors.affiliation: Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Teviot, Medical School, Edinburgh, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Simpson
mesh_terms: D001249:Asthma / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012141:Respiratory Tract Infections / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D000078202:Systematic Reviews as Topic; D016896:Treatment Outcome; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines
keywords: INFECTIOUS DISEASES