title: A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans.
abstract: A new indole alkaloid named bufobutarginine (1), along with three known bufotenines, namely, serotonin (2), bufotenidine (3), and bufotenine (4), were isolated from the water extract of toad venom. Their structures were elucidated by spectral methods. This is the first time that arginine has been found to be involved in the biosynthesis of bufotenines in parotid of toad. The cytotoxic activities of these compounds have been assayed against A375 and A549 cell lines by the MTT method; however, they showed no cytotoxic activities.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. yhdai2008@aliyun.com.
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Dai
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. sb.prove@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. xmywd@vip.sina.com.
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Xia
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. wangandong19891220@163.com.
authors.forename: An-Dong
authors.initials: AD
authors.lastname: Wang
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. cyl855@163.com.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Chen
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. liudongchun@outlook.com.|Laboratory of China-Korea Molecular Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. liudongchun@outlook.com.
authors.forename: Dong-Chun
authors.initials: DC
authors.lastname: Liu
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. dongwang@syphu.edu.cn.|Laboratory of China-Korea Molecular Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. dongwang@syphu.edu.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000633:toxicity; D000664:Amphibian Venoms / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D002023:Bufo bufo; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000664:Amphibian Venoms; D007211:Indoles; C030374:indole
keywords: Bufo bufo gargarizans; bufobutarginine; cytotoxic activity; toad venom