title: Genomic and Epigenomic Landscape in Meningioma.
abstract: Meningiomas are the most common primary intracranial neoplasms in adults. Despite their prevalence, their biologic underpinnings remain incompletely described. The recent application of unbiased next-generation sequencing and epigenomic approaches has implicated a new array of candidate biomarkers and oncogenic drivers. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in an era of biology-informed precision medicine.
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis Street, PBB-3, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Wenya Linda
authors.initials: WL
authors.lastname: Bi
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis Street, PBB-3, Boston, MA, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Mei
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Agarwalla
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Rameen
authors.initials: R
authors.lastname: Beroukhim
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis Street, PBB-3, Boston, MA, USA. Electronic address: idunn@partners.org.
authors.forename: Ian F
authors.initials: IF
authors.lastname: Dunn
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D009154:Mutation
keywords: Epigenetics; Genomics; Meningioma; Molecular taxonomy; Precision medicine