title: PHARMACOLOGIC TREATMENT OF HYPERALGESIA EXPERIMENTALLY INDUCED BY NUCLEUS PULPOSUS.
abstract: OBJECTIVE
  To evaluate the effect of anti-inflammatory drugs (dexamethasone, indomethacin, atenolol and indomethacin plus atenolol) and analgesic drugs (morphine) on hyperalgesia experimentally induced by the nucleus pulposus (NP) in contact with the L5 dorsal root ganglion (DRG).
  
  
  METHODS
  Thirty male Wistar rats of weights ranging from 220 to 250 g were used in the study. Hyperalgesia was induced by means of a fragment of NP removed from the sacrococcygeal region that was placed in contact with the L5 dorsal root ganglion. The 30 animals were divided into experimental groups according to the drug used. The drugs were administered for two weeks after the surgical procedure to induce hyperalgesia. Mechanical and thermal hyperalgesia was evaluated using the paw pressure test, von Frey electronic test and Hargreaves test, over a seven-week period.
  
  
  RESULTS
  The greatest reduction of hyperalgesia was observed in the group of animals treated with morphine, followed by dexamethasone, indomethacin and atenolol. Reductions in hyperalgesia were observed after drug administration ceased, except for the group of animals treated with morphine, in which there was an increase in hyperalgesia after discontinuation of the treatment.
  
  
  CONCLUSIONS
  Hyperalgesia induced by NP contact with the DRG can be reduced through administration of anti-inflammatory and analgesic drugs, but a greater reduction was observed with the administration of dexamethasone.
authors.affiliation: Postgraduate Student in the Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirao Preto School of Medicine, University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil.
authors.forename: André Luiz
authors.initials: AL
authors.lastname: de Souza Grava
authors.affiliation: Postgraduate Student in the Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil.
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Ferrari
authors.affiliation: Supervising Professor in the Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil.
authors.forename: Carlos Amílcar
authors.initials: CA
authors.lastname: Parada
authors.affiliation: Titular Professor of the Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirao Preto School of Medicine, University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil.
authors.forename: Helton Luiz Aparecido
authors.initials: HL
authors.lastname: Defino
keywords: Hyperalgesia; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Spine; Wistar Rats