title: HLA genes as modifiers of response to IFN-β-1a therapy in relapsing-remitting multiple sclerosis.
abstract: OBJECTIVE
  This study investigated the influence of HLA class-I and -II genes in the response to IFN-β in relapsing-remitting multiple sclerosis (MS) patients.
  
  
  METHODS
  In this cohort, 231 relapsing-remitting MS patients who are classified into IFN-β responders (n = 146) and nonresponders (n = 85) and 180 ethnic-matched healthy controls were analyzed. Clinical outcome of IFN-β therapy particularly Expanded Disability Status Scale scores were evaluated in relation to HLA-A, -B and -DRB1 alleles and haplotypes.
  
  
  RESULTS
  Increased frequencies of HLA-DRB1*04 allele and HLA-A*03-B*44-DRB1*04 haplotype, and decreased frequency of HLA-B*15 were associated with better response to IFN-β treatment.
  
  
  CONCLUSIONS
  The possibility of genetic screening particularly HLA typing prior to starting IFN-β therapy for MS may permit the identification of likely responders or nonresponders.
authors.affiliation: Department of Neuroogy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mehrdokht
authors.initials: M
authors.lastname: Mazdeh
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Taheri
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Arezou
authors.initials: A
authors.lastname: Sayad
authors.affiliation: Centre de Recherche d'Immunologie et d'Hématologie, Universite de Strasbourg, Strasbourg, France.
authors.forename: Siamak
authors.initials: S
authors.lastname: Bahram
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mir Davood
authors.initials: MD
authors.lastname: Omrani
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Movafagh
authors.affiliation: Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Tokyo, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.affiliation: Tehran Medical Genetics Laboratory, Tehran, Iran.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Akbari
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Rezvan
authors.initials: R
authors.lastname: Noroozi
authors.affiliation: Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Mahdieh Ave, Lona Park, Hamadan, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hajilooi
authors.affiliation: Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Mahdieh Ave, Lona Park, Hamadan, Iran.|Molecular Immunology Research Group, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Sh Fahmideh Blv, Lona Park, Hamadan, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Solgi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D000068556:Interferon beta-1a / Q000627:therapeutic use*; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000235:genetics; D011446:Prospective Studies
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains; D000068556:Interferon beta-1a
keywords: HLA; IFN-β; multiple sclerosis