title: Robot-Assisted Radical Prostatectomy vs. Open Retropubic Radical Prostatectomy for Prostate Cancer: A Systematic Review and Meta-analysis.
abstract: Open retropubic radical prostatectomy (ORP) remains the "gold standard" for surgical treatment of clinically localized prostate cancer (PCa). Robot-assisted radical prostatectomy (RARP) is a robotic surgery used worldwide. The aim of this study is to collect the data available in the literature on RARP and ORP, and further evaluate the overall safety and efficacy of RARP vs. ORP for the treatment of clinically localized PCa. A literature search was performed using electronic databases between January 2009 and October 2013. Clinical data such as operation duration, transfusion rate, positive surgical margins (PSM), nerve sparing, 3- and 12-month urinary continence, and potency were pooled to carry out meta-analysis. Six studies were enrolled for this meta-analysis. The operation duration of RARP group was longer than that of ORP group (weighted mean difference = 64.84). There was no statistically significant difference in the transfusion rate, PSM rate, and between RARP and ORP (transfusion rate, OR = 0.30; PSM rate, OR = 0.94). No significant difference was seen in 3- and 12-month urinary continence recovery (3 months, OR = 1.32; 12 months, OR = 1.30). There was a statistically significant difference in potency between the 3- and 12-month groups (3 months, OR = 2.80; 12 months, OR = 1.70). RARP is a safe and feasible surgical technique for the treatment of clinically localized PCa owing to the advantages of fewer perioperative complications and quicker patency recovery.
authors.affiliation: Department of Urologic Surgery, Changzheng Hospital of the Second Military Medical University, Shanghai, 200003 China.
authors.forename: Xiu-Wu
authors.initials: XW
authors.lastname: Pan
authors.affiliation: Department of EENT & Plastic and Maxillofacial Surgery, Nangang Branch of Heilongjiang Provincial Hospital, No. 405 Guogeli Street, Nangang District, Harbin, 150001 Heilongjiang China.
authors.forename: Xin-Ming
authors.initials: XM
authors.lastname: Cui
authors.affiliation: Department of Urologic Surgery, General Hospital of Beijing Military Command, No. 5 Nanmencang, Dongcheng District, Beijing, 100700 China.
authors.forename: Jing-Fei
authors.initials: JF
authors.lastname: Teng
authors.affiliation: Department of Urologic Surgery, First Hospital of Ningbo City, Affiliated Medical School of Ningbo University, Ningbo, 315010 Zhejiang China.
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: Zhang
authors.affiliation: Department of Urologic Surgery, Changzheng Hospital of the Second Military Medical University, Shanghai, 200003 China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Department of Urologic Surgery, Changzheng Hospital of the Second Military Medical University, Shanghai, 200003 China.
authors.forename: Fa-Jun
authors.initials: FJ
authors.lastname: Qu
authors.affiliation: Department of Urologic Surgery, Changzheng Hospital of the Second Military Medical University, Shanghai, 200003 China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Urologic Surgery, Changzheng Hospital of the Second Military Medical University, Shanghai, 200003 China.
authors.forename: Xin-Gang
authors.initials: XG
authors.lastname: Cui
authors.affiliation: Department of Urologic Surgery, Changzheng Hospital of the Second Military Medical University, Shanghai, 200003 China.
authors.forename: Dan-Feng
authors.initials: DF
authors.lastname: Xu
keywords: Open retropubic radical prostatectomy; Prostate cancer; Robot-assisted radical prostatectomy