title: Nanocarrier-based co-delivery of small molecules and siRNA/miRNA for treatment of cancer.
abstract: Aberrant gene expression can trigger several vital molecular events that not only result in carcinogenesis but also cause chemoresistance, metastasis and relapse. Gene-based therapies using siRNA/miRNA have been suggested as new treatment method to improve the current regimen. Although these agents can restore the normal molecular cascade thereby resensitizing the cancer cells, delivering a standard regimen (either subsequently or simultaneously) is necessary to achieve the therapeutic benefit. However, co-delivery using a single carrier could give an additional advantage of similar biodistribution profile of the loaded agents. While much research has been carried out in this field in recent years, challenges involved in designing combination formulations including efficient coloading, stability, appropriate biodistribution and target specificity have hampered their clinical translation. This article highlights current aspects of nano-carriers used for co-delivery of small molecules and genes to treat cancer.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani Campus, Vidya Vihar, Pilani - 333 031 (Rajasthan), India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Chitkara
authors.affiliation: Novartis Healthcare Pvt. Ltd, Hyderabad, Andhra Pradesh, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani Campus, Vidya Vihar, Pilani - 333 031 (Rajasthan), India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Mittal
mesh_terms: D050091:Dendrimers / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008055:Lipids / Q000737:chemistry; D035683:MicroRNAs / Q000008:administration & dosage / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D011108:Polymers / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D008055:Lipids; D035683:MicroRNAs; D011108:Polymers; D034741:RNA, Small Interfering
keywords: co-delivery; dendriplexes; lipoplexes; miRNA; micelleplexes; nanocarriers; polyplexes; siRNA; small molecules