title: CLINICAL INFECTION OF TWO CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 1B.
abstract: The ability of prior infection from one elephant endotheliotropic herpesvirus (EEHV) type to protect against clinical or lethal infection from others remains an important question. This report describes viremia and subsequent shedding of EEHV1B in two juvenile 4-yr-old Asian elephants within 3 wk or 2 mo following significant infections caused by the rarely seen EEHV4. High levels of EEHV1B shedding were detected in the first elephant prior to emergence of infection and viremia in the second animal. The EEHV1B virus associated with both infections was identical to the strain causing infection in two herd mates previously. High EEHV viremia correlated with leukopenia and thrombocytopenia, which was followed by leukocytosis and thrombocytosis when clinical signs started to resolve. The observations from these cases should be beneficial for helping other institutions monitor and treat elephants infected with EEHV1, the most common virus associated with lethal hemorrhagic disease.
authors.forename: Angela
authors.initials: A
authors.lastname: Fuery
authors.forename: Jie
authors.initials: J
authors.lastname: Tan
authors.forename: RongSheng
authors.initials: R
authors.lastname: Peng
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Flanagan
authors.forename: Maryanne E
authors.initials: ME
authors.lastname: Tocidlowski
authors.forename: Lauren L
authors.initials: LL
authors.lastname: Howard
authors.forename: Paul D
authors.initials: PD
authors.lastname: Ling
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000836:Animals, Zoo; D000998:Antiviral Agents / Q000627:therapeutic use; D004606:Elephants; D000077595:Famciclovir; D006564:Herpesviridae / Q000145:classification* / Q000235:genetics; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D015075:2-Aminopurine; D000077595:Famciclovir
keywords: Asian elephant; EEHV1B; Elephas maximus; Famciclovir; qPCR