title: Biomonitoring of prenatal analgesic intake and correlation with infantile anti-aeroallergens IgE.
abstract: An association between prenatal acetaminophen or ibuprofen intake and an increased risk of asthma and increased IgE level in children is discussed in various epidemiological studies. Although the molecular mechanistic link is still unknown, the question whether or not acetaminophen and/or ibuprofen are safe pain medications during pregnancy arose. In this study, we associate maternal acetaminophen and ibuprofen intake during pregnancy and breastfeeding to infantile asthma phenotypes and elevated IgE level. Therefore, we analysed questionnaires from a local mother-child cohort and monitored drug intake by LC-MS biomonitoring in urine. No association was found between drug intake and any analysed health outcome using questionnaire data. For the information obtained from biomonitoring, no association was found for ibuprofen and acetaminophen intakes during breastfeeding. However, an association between prenatal acetaminophen intake and increased infantile IgEs related to aeroallergens was statistically detected, but not for asthma phenotypes.
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Leipzig, Leipzig, Germany.|Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Hoeke
authors.affiliation: Department of Environmental Immunology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Roeder
authors.affiliation: Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Mueller
authors.affiliation: Department of Clinical Pharmacy, Institute of Pharmacy, University of Leipzig, Leipzig, Germany.|Drug Safety Center, University Hospital Leipzig and University of Leipzig, Leipzig, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Bertsche
authors.affiliation: Children's Hospital, Municipal Hospital St. Georg Leipzig, Affiliated to the University of Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Borte
authors.affiliation: Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Rolle-Kampczyk
authors.affiliation: Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany.|Department of Biotechnology, Chemistry and Environmental Engineering Aalborg University, Aalborg, Denmark.|Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: von Bergen
authors.affiliation: Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany.|Institute of Forensic Medicine, University Hospital Jena, Jena, Germany.
authors.forename: D K
authors.initials: DK
authors.lastname: Wissenbach
mesh_terms: D000485:Allergens / Q000276:immunology*; D000700:Analgesics / Q000009:adverse effects*; D000818:Animals; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D011247:Pregnancy; D012621:Seasons; D013997:Time Factors
chemical_list: D000485:Allergens; D000700:Analgesics; D007073:Immunoglobulin E
keywords: IgE; SX1; acetaminophen; prenatal exposure