title: PyMIF enhances the inflammatory response in a rodent model by stimulating CD11b(+) Ly6C(+) cells accumulation in spleen.
abstract: Macrophage migration inhibitory factor (PMIF) expressed by Plasmodium parasites has been proved to be similar to the mammalian MIF in both structure and biological activity and is a critical upstream regulator in antimalaria innate immunity. In this work, using a genetically modified (MIF-KO) strain of highly lethal rodent Plasmodium yoelii 17XL (Py17XL), we found that PyMIF could increase the secretion of pro-inflammatory factors by eliciting the CD11b(+) Ly6C(+) cells accumulated in the spleen of infected mouse. In addition, the chemotactic effect of PyMIF was demonstrated to associate with cell receptors CXCR2, CXCR4 and the cell surface markers ICAM-1, LFA-4.
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: D
authors.initials: D
authors.lastname: Shao
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: M
authors.initials: M
authors.lastname: Luo
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: M
authors.initials: M
authors.lastname: Yao
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Hao
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Wei
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: W
authors.initials: W
authors.lastname: Deng
authors.affiliation: Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D000950:Antigens, Ly / Q000276:immunology*; D039481:CD11b Antigen / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010967:Plasmodium yoelii / Q000276:immunology* / Q000502:physiology; D015800:Protozoan Proteins / Q000276:immunology*; D019718:Receptors, CXCR4 / Q000276:immunology; D023063:Receptors, Interleukin-8B / Q000276:immunology; D013154:Spleen / Q000276:immunology* / Q000469:parasitology
chemical_list: D000950:Antigens, Ly; D039481:CD11b Antigen; C514936:CXCR4 protein, mouse; C494192:Ly-6C antigen, mouse; D008263:Macrophage Migration-Inhibitory Factors; D015800:Protozoan Proteins; D019718:Receptors, CXCR4; D023063:Receptors, Interleukin-8B
keywords: immunological terms; malaria