title: Discovery of molluscicidal and cercaricidal activities of 3-substituted quinazolinone derivatives by a scaffold hopping approach using a pseudo-ring based on the intramolecular hydrogen bond formation.
abstract: Discovery of novel topological agents against Oncomelania hupensis snails and cercariae remains a significant challenge in current Schistosomiasis control. A pseudo-ring formed from salicylanilide by an intramolecular hydrogen bond led to the discovery of 3-substituted quinazolinone derivatives which showed a potent molluscicidal and cercaricidal activities.
authors.affiliation: Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
authors.forename: Lv-Yin
authors.initials: LY
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China. Electronic address: ydli2011@163.com.
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Li
authors.affiliation: Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
authors.forename: Ren-Miao
authors.initials: RM
authors.lastname: Wu
authors.affiliation: Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China. Electronic address: yangdq@scnu.edu.cn.
authors.forename: Ding-Qiao
authors.initials: DQ
authors.lastname: Yang
authors.affiliation: Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China. Electronic address: fanxl@gnnu.cn.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Fan
mesh_terms: D000818:Animals; D058487:Cercaria / Q000187:drug effects*; D055808:Drug Discovery; D008975:Molluscacides / Q000737:chemistry / Q000494:pharmacology*; D052999:Quinazolinones / Q000737:chemistry / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects*
chemical_list: D008975:Molluscacides; D052999:Quinazolinones
keywords: Intramolecular hydrogen bond; Molluscicidal and cercaricidal agents; Quinazolinones; Scaffold hopping; Structure based drug design