title: Current role of selective internal radiation with yttrium-90 in liver tumors.
abstract: An expert panel met to review the evidence for selective internal radiation therapy (SIRT) using yttrium-90 microspheres in hepatocellular carcinoma and metastases from colorectal cancer and neuroendocrine tumors. There is now convincing evidence for the safety and efficacy of SIRT in these situations albeit mostly from retrospective cohort studies. There are a number of ongoing prospective randomized controlled clinical trials investigating the role of SIRT in liver tumors; however, data from these trials are still several years away (although the SIRFLOX study has been recently published). In this evolving environment, published evidence and the authors' experience were used to summarize the current and potential role of SIRT in the management of hepatocellular carcinoma of intermediate or advanced stage and in liver-dominant metastatic colorectal cancer and metastatic neuroendocrine tumors.
authors.affiliation: Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Wan Yee
authors.initials: WY
authors.lastname: Lau
authors.affiliation: Singapore Clinical Research Institute, Singapore.
authors.forename: Yee Leong
authors.initials: YL
authors.lastname: Teoh
authors.affiliation: Department of Hepatology, University of Medicine 1, Yangon, Ministry of Health, Myanmar.
authors.forename: Khin Maung
authors.initials: KM
authors.lastname: Win
authors.affiliation: Department of Radiology, Taipei Veterans General Hospital & School of Medicine, National Yang-Ming University Taipei, Taiwan.
authors.forename: Rheun-Chuan
authors.initials: RC
authors.lastname: Lee
authors.affiliation: Department of Surgery, The Medical City, Pasig City, Metro Manila, Philippines.|Center for Liver Disease Management & Transplantation, The Medical City, Pasig City, Metro Manila, Philippines.
authors.forename: Vanessa H
authors.initials: VH
authors.lastname: de Villa
authors.affiliation: Department of Radiology, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Yun Hwan Joseph
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Po-Chin
authors.initials: PC
authors.lastname: Liang
authors.affiliation: Department of Radiology, Makati Medical Center, Philippines.
authors.forename: Ramon S
authors.initials: RS
authors.lastname: Santos-Ocampo
authors.affiliation: Department of Diagnostic Radiology, Singapore General Hospital, Singapore.
authors.forename: Richard Hoau Gong
authors.initials: RH
authors.lastname: Lo
authors.affiliation: Division of Gastroenterology & Hepatology, National University Centre for Organ Transplantation, National University Hospital, Singapore.
authors.forename: Kieron Boon Leng
authors.initials: KB
authors.lastname: Lim
authors.affiliation: Division of Medical Oncology, National Cancer Centre, Singapore.
authors.forename: David Wai Meng
authors.initials: DW
authors.lastname: Tai
authors.affiliation: Department of Nuclear Medicine & PET, Singapore General Hospital, Singapore.
authors.forename: David Chee Eng
authors.initials: DC
authors.lastname: Ng
authors.affiliation: Department of Diagnostic Radiology, Singapore General Hospital, Singapore.
authors.forename: Farah Gillan
authors.initials: FG
authors.lastname: Irani
authors.affiliation: Department of Diagnostic Radiology, Singapore General Hospital, Singapore.
authors.forename: Apoorva
authors.initials: A
authors.lastname: Gogna
authors.affiliation: Department of Surgical Oncology, National Cancer Centre Singapore, 169610 Singapore.|Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Pierce Kah-Hoe
authors.initials: PK
authors.lastname: Chow
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy*; D011446:Prospective Studies; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes
keywords: liver cancer; selective internal radiation; transarterial chemoembolization; yttrium 90 microspheres