title: Hyperoxic oxidative stress during abdominal surgery: a randomized trial.
abstract: The hypothesis of our study is that during anesthesia, administration of 80 % oxygen concentration increases oxidative stress more than 40 % oxygen.
  
  
  
  Forty ASA I-II patients were included in a randomized, single-blind study. Expiratory tidal volumes (ETV) were measured before induction and after extubation. After ventilation with 0.8 FiO2 and intubation, mini-bronchoalveolar lavage (mini-BAL), arterial blood gas (ABG), and blood samples were taken. Patients were randomly assigned to receive 0.8 (group I) or 0.4 (group II) FiO2 during management. Before extubation, mini-BAL, ABG, blood samples were taken. PaO2/FiO2, lactate, malondialdehyde (MDA), protein carbonyl (PCO), superoxide dismutase (SOD), total sulfhydryl (T-SH), non-protein sulfhydryl (NPSH), and protein sulfhydryl (PSH) were measured. In both groups, mean arterial pressure and heart rate values were recorded with 30-min intervals.
  
  
  
  ETV values were higher in group II after extubation. PaO2/FiO2 values were higher in group II after extubation compared to group I. In both groups, plasma PCO, SOD, and T-SH levels increased significantly before extubation, whereas the increase in MDA was not significant between groups. Plasma PCO, T-SH, and lactate levels were higher in group I, and plasma SOD, and PSH were higher in group I before extubation. In both groups, MDA, SOD, T-SH, and NPSH levels in mini-BAL increased significantly before extubation. Between-group comparisons, PCO, T-SH, PSH, and NPSH were significantly higher in the BAL samples of group II, and MDA levels were higher in group I.
  
  
  
  We found that 80 % FiO2 decreased ETV and PaO2/FiO2 and increased lactate levels and oxidative stress more, inhibiting antioxidant response compared to 40 % FiO2.
authors.affiliation: Department of Anesthesiology and Reanimation, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, 34040, Istanbul, Turkey.
authors.forename: Guniz M
authors.initials: GM
authors.lastname: Koksal
authors.affiliation: Department of Anesthesiology and Reanimation, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, 34040, Istanbul, Turkey.
authors.forename: Yalim
authors.initials: Y
authors.lastname: Dikmen
authors.affiliation: Department of Anesthesiology and Reanimation, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, 34040, Istanbul, Turkey. emreerbabacan@hotmail.com.
authors.forename: Emre
authors.initials: E
authors.lastname: Erbabacan
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, 34040, Istanbul, Turkey.
authors.forename: Seval
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, 34040, Istanbul, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Çakatay
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, 34040, Istanbul, Turkey.
authors.forename: Mustafa Erinc
authors.initials: ME
authors.lastname: Sitar
authors.affiliation: Department of Anesthesiology and Reanimation, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, 34040, Istanbul, Turkey.
authors.forename: Fatis
authors.initials: F
authors.lastname: Altindas
mesh_terms: D000328:Adult; D000368:Aged; D060666:Airway Extubation; D000975:Antioxidants / Q000378:metabolism*; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D010100:Oxygen / Q000008:administration & dosage*; D016037:Single-Blind Method; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D010100:Oxygen
keywords: Antioxidant response elements; Oxidative stress; Oxygen inhalation therapy; Postoperative pulmonary atelectasis