title: Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model.
abstract: The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.
authors.affiliation: Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (IIM-CSIC), E-36208 Vigo, Galicia, Spain; Department of Analytical Chemistry, Nutrition and Bromatology and Research Institute for Food Analysis (I.I.A.A.), University of Santiago de Compostela, E-15782 Santiago de Compostela, Galicia, Spain. Electronic address: gabrieldasilvaalonso@gmail.com.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dasilva
authors.affiliation: Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (IIM-CSIC), E-36208 Vigo, Galicia, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Pazos
authors.affiliation: Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (IIM-CSIC), E-36208 Vigo, Galicia, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Egido
authors.affiliation: Instituto de Química Avanzada de Catalunya (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.
authors.forename: Jara
authors.initials: J
authors.lastname: Pérez-Jiménez
authors.affiliation: Instituto de Química Avanzada de Catalunya (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.
authors.forename: Josep Lluis
authors.initials: JL
authors.lastname: Torres
authors.affiliation: Unidad de Farmacología, Facultad de Medicina, Universidad Rovira i Virgili, Sant Llorenç 21, E-43201 Reus, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Giralt
authors.affiliation: Unidad de Farmacología, Facultad de Medicina, Universidad Rovira i Virgili, Sant Llorenç 21, E-43201 Reus, Spain.
authors.forename: María-Rosa
authors.initials: MR
authors.lastname: Nogués
authors.affiliation: Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (IIM-CSIC), E-36208 Vigo, Galicia, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Medina
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000737:chemistry*; D007249:Inflammation; D008055:Lipids / Q000737:chemistry*; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats
chemical_list: D008055:Lipids; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
keywords: DHA; EPA; Inflammation; Lipid mediators; Metabolic Syndrome; Oxidative stress; SHROB