title: Evaluation of the risk factors of asymptomatic vertebral fractures in postmenopausal women with osteopenia at the femoral neck.
abstract: OBJECTIVE
  To identify risk factors of asymptomatic vertebral fracture (aVF) in postmenopausal women with osteopenia at the femoral neck and to evaluate the association between the number of aVFs and the risk of major and hip osteoporotic fracture calculated with the FRAX(®) algorithm.
  
  
  METHODS
  Epidemiological case-series study with data collected transversally.
  
  
  RESULTS
  728 postmenopausal women with osteopenia were included: 284 (39.0%) had aVF, of whom 200 (70.4%) had prior fragility fractures (FF). The likelihood of having an osteoporotic fracture in the next 10 years increased significantly with the number of aVF. The percentage of women with height loss, which was assessed as the difference between the greatest height reported by participants and that measured at inclusion, was higher in women with an aVF (OR 3.77, 95% CI 2.75-5.16, p<0.05). Multivariate analysis showed that prior FF, height loss and race were factors associated with the presence of aVF.
  
  
  CONCLUSIONS
  In this group of postmenopausal women with osteopenia at the femoral neck, the presence of an aVF correlated with a higher risk of estimated major osteoporotic and hip fractures as calculated using the FRAX(®) algorithm. Height loss and prior FF were associated with the presence of aVF.
authors.affiliation: Department of Pediatrics, Obstetrics and Gynecology, Universidad de Valencia y Hospital Clínico Universitario, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Cano
authors.affiliation: Hospital Materno-Infantil Vall d'Hebron, Menopause Unit, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Baró
authors.affiliation: Hospital San Carlos, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Fernández
authors.affiliation: Medical Department, MSD, Madrid, Spain. Electronic address: veronica.inaraja@merck.com.
authors.forename: V
authors.initials: V
authors.lastname: Inaraja
authors.affiliation: Medical Department, MSD, Madrid, Spain.
authors.forename: C A
authors.initials: CA
authors.lastname: García-Domínguez
mesh_terms: D000368:Aged; D000465:Algorithms; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications*; D005260:Female; D005272:Femur Neck; D006620:Hip Fractures / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D058866:Osteoporotic Fractures / Q000453:epidemiology*; D017698:Postmenopause; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D016103:Spinal Fractures / Q000453:epidemiology* / Q000209:etiology
keywords: Asymptomatic vertebral fractures; FRAX(®); Osteopenia; Postmenopausal women; Risk factors