title: Chronic Recurrent Vogt-Koyanagi-Harada Disease and Development of 'Sunset Glow Fundus' Predict Worse Retinal Sensitivity.
abstract: OBJECTIVE
  To investigate prognostic factors for retinal sensitivity assessed by microperimetry in patients with Vogt-Koyanagi-Harada (VKH) disease.
  
  
  METHODS
  In total, 34 patients with initial-onset acute disease and 19 patients with chronic recurrent disease were retrospectively evaluated.
  
  
  RESULTS
  The mean follow-up period was 40.4 ± 40.5 months. Sensitivity was significantly worse in eyes with more severe anterior segment inflammation at presentation, as indicated by the presence of mutton-fat keratic precipitates, anterior chamber reaction ≥2+, and posterior synechiae. Chronic recurrent presentation, development of complications, and 'sunset glow fundus' were significantly associated with worse sensitivity. Using logistic regression analysis, better sensitivity was significantly associated with initial-onset acute presentation (odds ratio, OR = 6.9; 95% confidence interval, CI = 1.53-9.66).
  
  
  CONCLUSIONS
  Chronic recurrent presentation and development of complications and 'sunset glow fundus' are associated with a worse sensitivity outcome.
authors.affiliation: a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.|b Dr Nasser Al-Rashid Research Chair in Ophthalmology.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Abu El-Asrar
authors.affiliation: a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Tariq
authors.initials: T
authors.lastname: Al Mudhaiyan
authors.affiliation: a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
authors.forename: AlHatoon A
authors.initials: AA
authors.lastname: Al Najashi
authors.affiliation: a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Suhail
authors.initials: S
authors.lastname: Hemachandran
authors.affiliation: a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Rajab
authors.initials: R
authors.lastname: Hariz
authors.affiliation: a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mousa
authors.affiliation: a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Al-Muammar
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012160:Retina / Q000503:physiopathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012189:Retrospective Studies; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: Immunomodulatory therapy; Vogt–Koyanagi–Harada disease; microperimetry; outcome; retinal sensitivity