title: Endoplasmic reticulum stress and its effects on renal tubular cells apoptosis in ischemic acute kidney injury.
abstract: Ischemia is the most frequent cause of acute kidney injury (AKI), which is characterized by apoptosis of renal tubular cell. A common result of ischemia in AKI is dysfunction of endoplasmic reticulum (ER), which causes the protein-folding capacity to lag behind the protein-folding load. The abundance of misfolded proteins stressed the ER and results in induction of the unfolded protein response (UPR). While the UPR is an adaptive response, over time it can result in apoptosis when cells are unable to recover quickly. Recent research suggests that ER stress is a major factor in renal tubular cell apoptosis resulting from ischemic AKI. Thus, ER stress may be an important new progression factor in the pathology of ischemic AKI. In this article, we review UPR signaling, describe pathology and pathophysiology mechanisms of ischemic AKI, and highlight the dual function of ER stress on renal tubular cell apoptosis.
authors.affiliation: a Department of Nephrology , Affiliated Hospital of Qingdao University , Qingdao , China ;
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: a Department of Nephrology , Affiliated Hospital of Qingdao University , Qingdao , China ;
authors.forename: Min
authors.initials: M
authors.lastname: Guo
authors.affiliation: a Department of Nephrology , Affiliated Hospital of Qingdao University , Qingdao , China ;
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: a Department of Nephrology , Affiliated Hospital of Qingdao University , Qingdao , China ;
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
authors.affiliation: b Center of Medical Research , Affiliated Hospital of Qingdao University , Qingdao , China ;
authors.forename: Yafei
authors.initials: Y
authors.lastname: Han
authors.affiliation: c Department of Endocrinology , Jiangsu Province Hospital of Chinese Medicine , Nanjing , China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: An
authors.affiliation: b Center of Medical Research , Affiliated Hospital of Qingdao University , Qingdao , China ;
authors.forename: Jisheng
authors.initials: J
authors.lastname: Zhang
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017209:Apoptosis; D018450:Disease Progression; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007511:Ischemia / Q000150:complications*; D007668:Kidney / Q000098:blood supply; D017510:Protein Folding
keywords: Acute kidney injury; apoptosis; endoplasmic reticulum; ischemic; renal tubular cell