title: Changes in Cerebral Blood Flow in the Postischemic Period.
abstract: Experiments on Wistar rats showed that blood flow in the cortex and subcortical brain structures was not completely restored within 21 days after transient ischemia caused by bilateral carotid artery occlusion with controlled hypotension. After 7 days of reinfusion, the end-diastolic blood flow velocity increases with simultaneous decrease in pulsation index, which indicates the decrease in peripheral vascular resistance. During the following 14 days, peripheral blood resistance increases, as was seen from the increased peak systolic blood flow velocity, mean blood flow velocity over the heart cycle, and pulsation index. These changes are likely a delayed manifestation of ischemic reperfusion injury to brain microvessels (no-reflow phenomenon) and are determined by changes in blood rheologiy and pial vessel lumen.
authors.affiliation: Laboratory of Physiology of the Cardiovascular and Lymphatic Systems, St. Petersburg, Russia. o_gorshkova@inbox.ru.
authors.forename: O P
authors.initials: OP
authors.lastname: Gorshkova
authors.affiliation: Laboratory of Physiology of the Cardiovascular and Lymphatic Systems, St. Petersburg, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Shuvaeva
authors.affiliation: Laboratory of Physiology of the Cardiovascular and Lymphatic Systems, St. Petersburg, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Lentsman
authors.affiliation: Laboratory of Digestion Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Artem'eva
authors.affiliation: Laboratory of Digestion Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: D P
authors.initials: DP
authors.lastname: Dvoretskii
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D002545:Brain Ischemia / Q000503:physiopathology*; D002339:Carotid Arteries / Q000601:surgery; D002540:Cerebral Cortex / Q000098:blood supply* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D007022:Hypotension; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000502:physiology*; D014655:Vascular Resistance
keywords: blood rheology; cerebral blood fl ow; cerebral ischemia; pial vessels