title: Abdominal girth and vertebral column length can adjust spinal anesthesia for lower limb surgery, a prospective, observational study.
abstract: BACKGROUND
  Studies have shown that abdominal girth and vertebral column length have high predictive value for spinal spread after administering a dose of plain bupivacaine. we designed a study to identify the specific correlations between abdominal girth, vertebral column length and a 0.5% dosage of plain bupivacaine, which should provide a minimum upper block level (T12) and a suitable upper block level (T10) for lower limb surgeries.
  
  
  METHODS
  A suitable dose of 0.5% plain bupivacaine was administered intrathecally between the L3 and L4 vertebrae for lower limb surgeries. If the upper cephalad spread of the patient by loss of pinprick discrimination was T12 or T10, the patient was enrolled in this study. Five patient variables and intrathecal plain bupivacaine dose were recorded. Linear regression and multiple regression analyses were performed.
  
  
  RESULTS
  Totals of 111 patients and 121 patients who lost pinprick discrimination at T12 and T10, respectively, were analyzed in this study. Linear regression analysis showed that only abdominal girth and plain bupivacaine dose were strongly correlated (r =-0.827 for T12, r = -0.806 for T10; both p < 0.0001). Multiple linear regression analysis showed that both abdominal girth and vertebral column length were the key determinants of plain bupivacaine dose (both p < 0.0001). R(2) was 0.874 and 0.860 for the loss of pinprick discrimination at T12 and T10, respectively.
  
  
  CONCLUSIONS
  Our data indicated that vertebral column length and abdominal girth were strongly correlated with the dosage of intrathecal plain bupivacaine for the loss of pinprick discrimination at T12 and T10. The two regression equations were YT12 = 3.547 + 0.045X1-0.044X2 and YT10 = 3.848 + 0.047X1- 0.046X2 (Y, 0.5% plain bupivacaine volume; X1, vertebral column length;and X 2, abdominal girth), which can accurately predict the minimum and suitable intrathecal bupivacaine dose for lower limb surgery to a great extent, separately.
authors.affiliation: Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.|Affiliation: Department of Anesthesiology, Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.
authors.forename: Qing-he
authors.initials: QH
authors.lastname: Zhou
authors.affiliation: Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Affiliation: Department of Anesthesiology, Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.
authors.forename: Chang-na
authors.initials: CN
authors.lastname: Wei
authors.affiliation: Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. zryanmin@zju.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Yan
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D000328:Adult; D000775:Anesthesia, Spinal / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D035002:Lower Extremity / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013131:Spine / Q000187:drug effects* / Q000378:metabolism; D055105:Waist Circumference / Q000187:drug effects* / Q000502:physiology
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine
keywords: Anaesthetic techniques; Anaesthetics local; Apinal cord; Bupivacaine; Sensory block; Subarachnoid