title: Soft-Tissue Sarcomas: An Update for Radiologists Based on the Revised 2013 World Health Organization Classification.
abstract: OBJECTIVE
  Soft-tissue sarcomas are a diverse group of malignancies, and our rapidly improving understanding of their molecular pathogenesis and treatment is leading to better clinical outcomes. The revised 2013 World Health Organization (WHO) classification of soft-tissue sarcomas introduced several important changes. We provide a comprehensive overview of the relevant changes for radiologists.
  
  
  CONCLUSIONS
  Rapid advances in the understanding of the pathogenesis and molecular biology of soft-tissue sarcomas led to major revisions in the 2013 WHO classification. To provide optimal multidisciplinary patient care, radiologists must remain up-to-date with the latest developments in the field of soft-tissue sarcomas to best correlate the histologic and imaging features of the various types of tumors and understand the unique patterns of treatment response and disease recurrence.
authors.affiliation: 1 Department of Radiology, University of Washington Medical Center and Seattle Cancer Care Alliance, 1959 NE Pacific St, Seattle, WA 98195.
authors.forename: Akshay D
authors.initials: AD
authors.lastname: Baheti
authors.affiliation: 1 Department of Radiology, University of Washington Medical Center and Seattle Cancer Care Alliance, 1959 NE Pacific St, Seattle, WA 98195.
authors.forename: Ryan B
authors.initials: RB
authors.lastname: O'Malley
authors.affiliation: 1 Department of Radiology, University of Washington Medical Center and Seattle Cancer Care Alliance, 1959 NE Pacific St, Seattle, WA 98195.
authors.forename: Sooah
authors.initials: S
authors.lastname: Kim
authors.affiliation: 2 Department of Imaging, Dana-Farber Cancer Institute, Boston, MA.
authors.forename: Abhishek R
authors.initials: AR
authors.lastname: Keraliya
authors.affiliation: 2 Department of Imaging, Dana-Farber Cancer Institute, Boston, MA.|3 Department of Radiology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Sree Harsha
authors.initials: SH
authors.lastname: Tirumani
authors.affiliation: 2 Department of Imaging, Dana-Farber Cancer Institute, Boston, MA.|3 Department of Radiology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Ramaiya
authors.affiliation: 1 Department of Radiology, University of Washington Medical Center and Seattle Cancer Care Alliance, 1959 NE Pacific St, Seattle, WA 98195.
authors.forename: Carolyn L
authors.initials: CL
authors.lastname: Wang
mesh_terms: D006801:Humans; D012509:Sarcoma / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014944:World Health Organization
keywords: World Health Organization (WHO) classification; soft-tissue sarcoma