title: Comparison of diameters of ipsilateral and contralateral internal mammary arteries by breast MRI in patients with unilateral breast cancer.
abstract: OBJECTIVE
  We compared maximal diameters of ipsilateral (IMA) and contralateral (IMA) internal mammary arteries in patients with unilateral breast cancer and analyze the implications of enlargements of ipsilateral or contralateral IMAs in relation to histopathologic factors.
  
  
  METHODS
  Of 568 women who underwent breast magnetic resonance imaging (MRI) examinations from January 2009 to May 2012, 196 had unilateral, histologically proven breast cancer. In 156 women, maximal IMA diameters in the second intercostal space were measured by two blinded radiologists in left and right sides using nonenhanced axial T2-weighted turbo spin-echo sequence images.
  
  
  RESULTS
  In the 156 study patients, mean maximal diameter of ipsilateral IMAs (2.37 ± 0.60 mm) was significantly larger than that of contralateral IMAs (2.03 ± 0.58 mm) (p = 0.00). Ipsilateral IMA enlargement was present in 66.7 % of the patients (104 of 156). Furthermore, ipsilateral IMA enlargement was found to be significantly associated with human epidermal growth factor receptor-2 (HER-2) expression (p = 0.039).
  
  
  CONCLUSIONS
  Maximal IMA diameter was significantly greater in ipsilateral sides in breast cancer patients. Findings suggest ipsilateral IMA enlargement detected by MRI might be a useful additional predictor of HER-2 expression in unilateral breast cancer.
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Nam
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea. kschoo0618@naver.com.
authors.forename: Ki Seok
authors.initials: KS
authors.lastname: Choo
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Ung Bae
authors.initials: UB
authors.lastname: Jeon
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Tae Un
authors.initials: TU
authors.lastname: Kim
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Jae-Yeon
authors.initials: JY
authors.lastname: Hwang
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Jeong A
authors.initials: JA
authors.lastname: Yeom
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Hee Seok
authors.initials: HS
authors.lastname: Jeong
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Yoon Young
authors.initials: YY
authors.lastname: Choi
authors.affiliation: Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan-si, 602-739, Korea.
authors.forename: Jin You
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Sang Hyup
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Hyun Yul
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Youn Joo
authors.initials: YJ
authors.lastname: Jung
authors.affiliation: Department of Family Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
authors.forename: Young Hye
authors.initials: YH
authors.lastname: Cho
mesh_terms: D000328:Adult; D000368:Aged; D001837:Body Weights and Measures / Q000379:methods; D001940:Breast / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008323:Mammary Arteries / Q000000981:diagnostic imaging*; D008875:Middle Aged; D012189:Retrospective Studies; D000069584:Unilateral Breast Neoplasms / Q000000981:diagnostic imaging*
keywords: Breast cancer; HER-2; Internal mammary artery; Magnetic resonance imaging