title: Antimicrobial Activity and Phylogenetic Analysis of Streptomyces Parvulus Dosmb-D105 Isolated from the Mangrove Sediments of Andaman Islands.
abstract: Actinomycetes, especially species of Streptomyces are prolific producers of pharmacologically significant compounds accounting for about 70% of the naturally derived antibiotics that are presently in clinical use. In this study, we used five solvents to extract the secondary metabolites from marine Streptomyces parvulus DOSMB-D105, which was isolated from the mangrove sediments of the South Andaman Islands. Among them, ethyl acetate crude extract showed maximum activity against 11 pathogenic bacteria and six fungi. Presence of bioactive compounds in the ethyl acetate extract was determined using GC-MS and the compounds detected in the ethyl acetate extract were matched with the National Institute of Standards and Technology (NIST) library. Totally eight compounds were identified and the prevalent compounds were 2 steroids, 2 alkaloids, 2 plasticizers, 1 phenolic and 1 alkane. Present study revealed that S. parvulus DOSMB-D105 is a promising species for the isolation of valuable bioactive compounds to combat pathogenic microbes.
authors.affiliation: Department of Ocean Studies and Marine Biology, Pondicherry University , Brookshabad Campus, Port Blair-744 112, Andaman Island , India.
authors.forename: R
authors.initials: R
authors.lastname: Baskaran
authors.affiliation: Department of Ocean Studies and Marine Biology, Pondicherry University , Brookshabad Campus, Port Blair-744 112, Andaman Island , India.
authors.forename: P M
authors.initials: PM
authors.lastname: Mohan
authors.affiliation: CAS in Marin Biology, Annamalai University , Parangipattai, Tamil Nadu-608 502 , India.
authors.forename: K
authors.initials: K
authors.lastname: Sivakumar
authors.affiliation: Department of Biotechnology, Himachal Pradesh University , Summer Hill, Shimla, India-171 005 , India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D019015:Geologic Sediments / Q000382:microbiology*; D007194:India; D062312:Islands; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010802:Phylogeny; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents
keywords: Andaman Islands; Streptomyces parvulus; actinobacteria; antimicrobial activity; bioactive compound