title: Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers.
abstract: OBJECTIVE
  Glioblastoma multiforme is a devastating disease with no curative options due to the difficulty in achieving sufficient quantities of effective chemotherapies into the tumor past the blood-brain barrier. Micelles loaded with temozolomide (TMZ) were designed to increase the delivery of this drug into the brain.
  
  
  METHODS
  pH-responsive micelles composed of distearoyl phosphoethanolamine-PEG-2000-amine and N-palmitoyl homocysteine were surface-functionalized with PDGF peptide and Dylight 680 fluorophore.
  
  
  CONCLUSIONS
  PDGF-micelles containing TMZ have specific uptake and increased killing in glial cells compared with untargeted micelles. In vivo studies demonstrated selective accumulation of PDGF-micelles containing TMZ in orthotopic gliomas implanted in mice. Targeted micelle-based drug carrier systems hold potential for delivery of a wide variety of hydrophobic drugs thereby reducing its systemic toxicity.
authors.affiliation: Department of Radiology & Radiological Sciences, Medical University of South Carolina, 68 President Street, MSC 120/BEB 213, Charleston, SC 29425, USA.
authors.forename: Kayla
authors.initials: K
authors.lastname: Miller
authors.affiliation: Department of Radiology & Radiological Sciences, Medical University of South Carolina, 68 President Street, MSC 120/BEB 213, Charleston, SC 29425, USA.|Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Suraj
authors.initials: S
authors.lastname: Dixit
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA.|Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Amy-Lee
authors.initials: AL
authors.lastname: Bredlau
authors.affiliation: Department of Radiology & Radiological Sciences, Medical University of South Carolina, 68 President Street, MSC 120/BEB 213, Charleston, SC 29425, USA.|Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Alfred
authors.initials: A
authors.lastname: Moore
authors.affiliation: Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Emilie
authors.initials: E
authors.lastname: McKinnon
authors.affiliation: Department of Radiology & Radiological Sciences, Medical University of South Carolina, 68 President Street, MSC 120/BEB 213, Charleston, SC 29425, USA.|Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, USA.|Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Broome
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems; D005909:Glioblastoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008819:Mice, Nude; D008823:Micelles; D010714:Phosphatidylethanolamines / Q000737:chemistry / Q000378:metabolism; D011522:Protons; D017479:Receptors, Platelet-Derived Growth Factor / Q000737:chemistry / Q000378:metabolism*; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003692:Delayed-Action Preparations; D008823:Micelles; D010714:Phosphatidylethanolamines; D011522:Protons; C038089:1,2-distearoylphosphatidylethanolamine; D003606:Dacarbazine; D017479:Receptors, Platelet-Derived Growth Factor; D000077204:Temozolomide
keywords: PDGF; glioblastoma; micelle; nanocarrier; temozolomide