title: Polymorphous low-grade adenocarcinoma: A Danish national study.
abstract: OBJECTIVE
  To present a national series of polymorphous low-grade adenocarcinoma (PLGA) patients, including survival rates and an analysis of prognostic factors.
  
  
  METHODS
  By merging three Danish nationwide registries, 73 patients diagnosed with PLGA from 1990 to 2005 were identified. Histological slides were reviewed and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by comparing Kaplan-Meier plots using the Mantel-Haenszel log-rank test.
  
  
  RESULTS
  Of the 73 patients, 47 (64%) were female. Median age was 58years. The most common location was the palate (73%). Median latency was five months. Recurrence was seen in 13% of patients. Overall survival (OS), disease-specific survival (DSS) and recurrence-free survival (RFS) rates after 10years were 73%, 99% and 83%, respectively. Univariate analyses suggested that free resection margins significantly improve RFS.
  
  
  CONCLUSIONS
  PLGA usually has an excellent survival outcome even in cases of advanced stage disease and locoregional recurrence. Primary choice of treatment should be complete surgical excision. Although there is no convincing evidence for the efficacy of adjuvant radiotherapy, it should still be considered, particularly in cases of involved resection margins and advanced stage disease. Late recurrences are common and respond well to salvage therapy.
authors.affiliation: Department of ORL - Head and Neck Surgery, Odense University Hospital, Denmark.
authors.forename: Mohammad Talal
authors.initials: MT
authors.lastname: Elhakim
authors.affiliation: Department of ORL - Head and Neck Surgery, Odense University Hospital, Denmark.
authors.forename: Helle
authors.initials: H
authors.lastname: Breinholt
authors.affiliation: Department of ORL - Head and Neck Surgery, Odense University Hospital, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Godballe
authors.affiliation: Department of Oncology, Aalborg University Hospital, Denmark.
authors.forename: Lisbeth Juhler
authors.initials: LJ
authors.lastname: Andersen
authors.affiliation: Department of Oncology, Aarhus University Hospital, Denmark.
authors.forename: Hanne
authors.initials: H
authors.lastname: Primdahl
authors.affiliation: Department of Oncology, Copenhagen University Hospital/Rigshospitalet, Denmark.
authors.forename: Claus A
authors.initials: CA
authors.lastname: Kristensen
authors.affiliation: Department of ORL - Head and Neck Surgery, Odense University Hospital, Denmark. Electronic address: Kristine.Bjoerndal@rsyd.dk.
authors.forename: Kristine
authors.initials: K
authors.lastname: Bjørndal
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D055815:Young Adult
keywords: National; Oral cancer; Polymorphous low-grade adenocarcinoma; Prognostic factors; Survival