title: Assessment of the direct cyclotron production of (99m)Tc: An approach to crisis management of (99m)Tc shortage.
abstract: Nowadays, the cyclotron production of technetium-99m ((99m)Tc) has been increased, due to the worldwide (99m)Tc generator shortage. In the present work, an improved strategy for the production of (99m)Tc, using the proton irradiation of the enriched (100)Mo was developed. The performance of this method in terms of the production yield, chemical purity, radiochemical purity, as well as radionuclide purity was evaluated. The average production yield was measured to be 356MBqμA(-1)h(-1). A good agreement was found between the calculated production yield and the experimental one. The radiochemical separation and total recovery yields of (99m)Tc were 92% and 69%, respectively. The radiochemical and the radionuclide purities of the (99m)Tc were 99% and >99.99% at the end of purification, respectively. The results of quality control tests (QC) support the concept that cyclotron-produced (99m)Tc is suitable for preparation of USP-compliant.
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran. Electronic address: mraboudzadeh@aeoi.org.ir.
authors.forename: Mohammad Reza Aboudzadeh
authors.initials: MR
authors.lastname: Rovais
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran.
authors.forename: Khosro
authors.initials: K
authors.lastname: Aardaneh
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Aslani
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Rahiminejad
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Yousefi
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Boulouri
keywords: (99m)Tc production; Cyclotron; Simulation; Targetry