title: Porous Covalent Triazine Polymer as a Potential Nanocargo for Cancer Therapy and Imaging.
abstract: A microporous covalent triazine polymer (CTP) network with a high surface area was synthesized via the Friedel-Crafts reaction and employed as a potential transport system for drug delivery and controlled release. The CTP was transformed to the nanoscale region by intense ultrasonication followed by filtration to yield nanoscale CTP (NCTP). This product showed excellent dispersibility in physiological solution while maintaining its chemical structure and porosity. An anticancer drug, doxorubicin (DOX), was loaded onto the NCTP through hydrophobic and π-π interactions, and its release was controlled at pH 4.8 and 7.4. The NCTP showed no toxicity toward cancer or normal cells, but the NCTP-DOX complex showed high efficacy against both types of cells in vitro. In-vitro cell imaging revealed that NCTP is a potential material for bioimaging. The potency of NCTP on cellular senescence was confirmed by the expression of senescence associated marker proteins p53 and p21. These results suggest that NCTP can be used as a new platform for drug delivery and imaging with potential applications in diagnosis and therapy.
authors.affiliation: Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University , Incheon, 402-751, Republic of Korea.
authors.forename: Arunkumar
authors.initials: A
authors.lastname: Rengaraj
authors.affiliation: Department of Chemistry and Chemical Engineering, Inha University , Incheon 402-751, Republic of Korea.
authors.forename: Pillaiyar
authors.initials: P
authors.lastname: Puthiaraj
authors.affiliation: Department of Energy and Materials Engineering, Dongguk University-Seoul , Seoul, 100-715, Republic of Korea.
authors.forename: Yuvaraj
authors.initials: Y
authors.lastname: Haldorai
authors.affiliation: Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University , Incheon, 402-751, Republic of Korea.
authors.forename: Nam Su
authors.initials: NS
authors.lastname: Heo
authors.affiliation: Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University , Incheon, 402-751, Republic of Korea.
authors.forename: Seung-Kyu
authors.initials: SK
authors.lastname: Hwang
authors.affiliation: Department of Energy and Materials Engineering, Dongguk University-Seoul , Seoul, 100-715, Republic of Korea.
authors.forename: Young-Kyu
authors.initials: YK
authors.lastname: Han
authors.affiliation: Department of Biological Engineering, Integrated Tissue Culture Laboratory, Inha University , Incheon, 402-751, Republic of Korea.
authors.forename: Soonjo
authors.initials: S
authors.lastname: Kwon
authors.affiliation: Department of Chemistry and Chemical Engineering, Inha University , Incheon 402-751, Republic of Korea.
authors.forename: Wha-Seung
authors.initials: WS
authors.lastname: Ahn
authors.affiliation: Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University , Incheon, 402-751, Republic of Korea.
authors.forename: Yun Suk
authors.initials: YS
authors.lastname: Huh
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D057054:Molecular Imaging; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D011108:Polymers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D016062:Porosity; D014227:Triazines / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D011108:Polymers; D014227:Triazines; D004317:Doxorubicin
keywords: biocompatible; covalent triazine polymer; drug delivery; fluorescence; porous material