title: Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics.
abstract: In addition to calcium phosphate-based ceramics, glass-based materials have been utilized as bone substitutes, and silicate in these materials has been suggested to contribute to their ability to stimulate bone repair. In this study, a silicate-containing α-tricalcium phosphate (α-TCP) ceramic was prepared using a wet chemical process. Porous granules composed of silicate-containing α-TCP, for which the starting composition had a molar ratio of 0.05 for Si/(P + Si), and silicate-free α-TCP were prepared and evaluated in vivo. When implanted into bone defects that were created in rat femurs, α-TCP ceramics either with or without silicate were biodegraded, generating a hybrid tissue composed of residual ceramic granules and newly formed bone, which had a tissue architecture similar to physiological trabecular structures, and aided regeneration of the bone defects. Supplementation with silicate significantly promoted osteogenesis and delayed biodegradation of α-TCP. These results suggest that silicate-containing α-TCP is advantageous for initial skeletal fixation and wound regeneration in bone repair.
authors.affiliation: Graduate School of Environmental Studies, Tohoku University, 6-6-20 Aoba, Aramaki, Aoba-ku, Sendai, 980-8579, Japan. kamitaka@mail.kankyo.tohoku.ac.jp.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kamitakahara
authors.affiliation: Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Tatsukawa
authors.affiliation: Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Shibata
authors.affiliation: Graduate School of Environmental Studies, Tohoku University, 6-6-20 Aoba, Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Umemoto
authors.affiliation: Graduate School of Environmental Studies, Tohoku University, 6-6-20 Aoba, Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
authors.forename: Taishi
authors.initials: T
authors.lastname: Yokoi
authors.affiliation: Faculty of Economics, Keio University, Building #2-101B, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8521, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ioku
authors.affiliation: Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002118:Calcium; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D017640:Silicates / Q000737:chemistry*; D013499:Surface Properties; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D017640:Silicates; C485828:alpha-tricalcium phosphate; D002118:Calcium