title: [EPIGENETIC FACTORS OF NEUROBIOLOGIC CHANGES IN FETUSES OF PREGNANT WOMEN WITH NEUROPSYCHIATRIC DISORDERS].
abstract: During prenatal development, the fetus is particularly vulnerable to the environmental harmful effects. It has been proved that the placenta is a significant modulator of the intrauterine environment that links maternal and fetal nervous systems. Emerging evidence indicates that epigenetic modifications prior to the birth may have substantial influence on brain development and may exert various neurobehavioral deficits. This review demonstrates association between maternal prenatal distress and depression and fetal long-term neurobiological and behavioral outcomes. Further investigation of the epigenetic dysregulation of fetal neurodevelopment may suggest new mechanisms in the interplay between genes and environment, and provide novel insights in the pathophysiology and prevention of neuropsychiatric disorders.
authors.forename: M
authors.initials: M
authors.lastname: Varadinova
authors.forename: R
authors.initials: R
authors.lastname: Metodieva
authors.forename: N
authors.initials: N
authors.lastname: Boyadzhieva
mesh_terms: D001921:Brain / Q000196:embryology* / Q000378:metabolism / Q000503:physiopathology; D003863:Depression / Q000150:complications; D044127:Epigenesis, Genetic; D005260:Female; D047109:Fetal Development; D018507:Gene Expression Regulation, Developmental; D059647:Gene-Environment Interaction; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications