title: The epidemiological and serological characteristics of measles in Dongguan, China, 2005-2014.
abstract: This study examined the epidemiological and serological characteristics of measles in Dongguan, China. From 2005 to 2014, a total of 8,224 measles cases were reported in Dongguan, 33.5% of which were aged <1 y and 30.6% >14 y. From 2005 to 2014, the proportion of the <1 y measles cases increased year by year from 24.3% to 47.9%. Of the cases aged ≥8 months (n = 6,768 cases), only 11.6% had been immunized with at least one dose of measles vaccine. Of the 2,213 cases who had never been immunized with measles vaccine, immigrants accounted for 82.4%. 52.4% of the measles cases were diagnosed with pneumonia, and 12 cases died from respiratory failure. Seroprevalence rate in women and their newborns was 86.0% and 82.5%, respectively. Measurement of serum measles antibody levels for infants aged less than 8 months indicated that seroprevalence rate dramatically declined from 97.3% at birth to 9.3% and 13.2% at 6- and 7- month old. The existence of a sufficient pool of unvaccinated people (especially immigrants) and decreased level of passively transferred measles antibodies in infants from vaccinated mothers contributed to the sustained transmission observed in Dongguan. In addition to high routine vaccination coverage, new strategies and innovations for measles vaccination are needed to eliminate measles.
authors.affiliation: a Department of Pathogen Biology, School of Public Health and Tropical Medicine , Southern Medical University , Guangzhou , China.
authors.forename: Ke
authors.initials: K
authors.lastname: Han
authors.affiliation: b Department of Immunization Program , Dongguan Center for Disease Control and Prevention , Dongguan , China.
authors.forename: Shaoli
authors.initials: S
authors.lastname: Chen
authors.affiliation: b Department of Immunization Program , Dongguan Center for Disease Control and Prevention , Dongguan , China.
authors.forename: Cuifei
authors.initials: C
authors.lastname: Tang
authors.affiliation: b Department of Immunization Program , Dongguan Center for Disease Control and Prevention , Dongguan , China.
authors.forename: Jinjun
authors.initials: J
authors.lastname: Wen
authors.affiliation: c Department of Inspection , Dongguan Center for Disease Control and Prevention , Dongguan , China.
authors.forename: Jingquan
authors.initials: J
authors.lastname: Li
authors.affiliation: d Department of Epidemiology and Biostatistics , Guangdong Medical College , Dongguan , China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Ni
authors.affiliation: a Department of Pathogen Biology, School of Public Health and Tropical Medicine , Southern Medical University , Guangzhou , China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008457:Measles / Q000453:epidemiology* / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D011247:Pregnancy; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: antibody; epidemiology; infant; measles; pregnant woman