title: Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults: A cross-sectional study.
abstract: BACKGROUND
  We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults.
  
  
  METHODS
  This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared.
  
  
  RESULTS
  Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obese participants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95% CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95% CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95% CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95% CI: 1.64-7.33).
  
  
  CONCLUSIONS
  NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.
authors.affiliation: Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea; Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, Republic of Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea; Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, Republic of Korea.
authors.forename: Choae
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea; Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, Republic of Korea.
authors.forename: Minsuk
authors.initials: M
authors.lastname: Oh
authors.affiliation: Sport and Medicine Research Center, INTOTO Inc., Seoul, Republic of Korea.
authors.forename: Jee-Aee
authors.initials: JA
authors.lastname: Im
authors.affiliation: Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Clinical Nursing Science, Yonsei University College of Nursing, Seoul, Republic of Korea; Nursing Policy and Research Institute, Biobehavioral Research Center, Yonsei University, Seoul, Republic of Korea.
authors.forename: Sang Hui
authors.initials: SH
authors.lastname: Chu
authors.affiliation: Department of Clinical Nursing Science, Yonsei University College of Nursing, Seoul, Republic of Korea; Nursing Policy and Research Institute, Biobehavioral Research Center, Yonsei University, Seoul, Republic of Korea. Electronic address: hkyulee@yuhs.ac.
authors.forename: Hyangkyu
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea; Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, Republic of Korea. Electronic address: jjeon@yonsei.ac.kr.
authors.forename: Justin Y
authors.initials: JY
authors.lastname: Jeon
mesh_terms: D050154:Adiposity; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000453:epidemiology; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D015995:Prevalence; D056910:Republic of Korea
chemical_list: D001786:Blood Glucose
keywords: Insulin resistance; Metabolic syndrome; Non-alcoholic fatty liver disease