title: Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid.
abstract: Archived resistance mutations compromise antiretroviral treatment. We have investigated 3 selected aviremic patients who had extensive historical resistance to their current regimen. All 3 patients underwent unstructured treatment interruptions associated to the re-emergence of wild-type virus before starting their current suppressive regimes. Almost all historical resistance mutations detected in plasma were found in circulating proviral deoxyribonucleic acid. None of the clones analyzed was fully resistant to the current antiretroviral regimen.
authors.affiliation: Departments of Microbiology.
authors.forename: Natalia
authors.initials: N
authors.lastname: Stella-Ascariz
authors.affiliation: Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain.
authors.forename: Rocio
authors.initials: R
authors.lastname: Montejano
authors.affiliation: Departments of Microbiology.
authors.forename: María
authors.initials: M
authors.lastname: Martin-Vicente
authors.affiliation: Departments of Microbiology.
authors.forename: Jesús
authors.initials: J
authors.lastname: Mingorance
authors.affiliation: Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Pérez-Valero
authors.affiliation: Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain.
authors.forename: José I
authors.initials: JI
authors.lastname: Bernardino
authors.affiliation: Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain.
authors.forename: Jose R
authors.initials: JR
authors.lastname: Arribas
keywords: HIV; proviral DNA; resistance; single genome sequencing