title: Screening of biologically active monosaccharides: growth inhibitory effects of d-allose, d-talose, and l-idose against the nematode Caenorhabditis elegans.
abstract: We compared the growth inhibitory effects of all aldohexose stereoisomers against the model animal Caenorhabditis elegans. Among the tested compounds, the rare sugars d-allose (d-All), d-talose (d-Tal), and l-idose (l-Ido) showed considerable growth inhibition under both monoxenic and axenic culture conditions. 6-Deoxy-d-All had no effect on growth, which suggests that C6-phosphorylation by hexokinase is essential for inhibition by d-All.
authors.affiliation: a Faculty of Agriculture, Department of Applied Biological Science , Kagawa University , Miki , Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sakoguchi
authors.affiliation: b Rare Sugar Research Center, Kagawa University , Miki , Japan.
authors.forename: Akihide
authors.initials: A
authors.lastname: Yoshihara
authors.affiliation: b Rare Sugar Research Center, Kagawa University , Miki , Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Izumori
authors.affiliation: a Faculty of Agriculture, Department of Applied Biological Science , Kagawa University , Miki , Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Sato
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000494:pharmacology*; D061245:Axenic Culture; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000254:growth & development; D005947:Glucose / Q000737:chemistry / Q000494:pharmacology*; D006593:Hexokinase / Q000378:metabolism; D006601:Hexoses / Q000737:chemistry / Q000494:pharmacology*; D010766:Phosphorylation; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D006601:Hexoses; C010997:idose; C002055:allose; D006593:Hexokinase; D005947:Glucose
keywords: Caenorhabditis elegans; aldohexose; growth inhibitory effect; rare sugar