title: [Repeated radiation dose effect and DNA repair: Importance of the individual factor and the time interval between the doses].
abstract: The dose fractionation effect is a recurrent question of radiation biology research that remains unsolved since no model predicts the clinical effect only with the cumulated dose and the radiobiology of irradiated tissues. Such an important question is differentially answered in radioprotection, radiotherapy, radiology or epidemiology. A better understanding of the molecular response to radiation makes possible today a novel approach to identify the parameters that condition the fractionation effect. Particularly, the time between doses appears to be a key factor since it will permit, or not, the repair of certain radiation-induced DNA damages whose repair rates are of the order of seconds, minutes or hours: the fractionation effect will therefore vary according to the functionality of the different repair pathways, whatever for tumor or normal tissues.
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Viau
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France.
authors.forename: A-F
authors.initials: AF
authors.lastname: Perez
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Bodgi
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Devic
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Granzotto
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France.
authors.forename: M L
authors.initials: ML
authors.lastname: Ferlazzo
authors.affiliation: Institut de radioprotection et sûreté nucléaire, BP 17, 92260 Fontenay-aux-Roses, France.
authors.forename: M
authors.initials: M
authors.lastname: Bourguignon
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Puisieux
authors.affiliation: Département de radiothérapie, centre Oscar-Lambret, ONCOLille, université de Lille, 3, rue Frédéric-Combemale, 59000 Lille, France.
authors.forename: T
authors.initials: T
authors.lastname: Lacornerie
authors.affiliation: Département de radiothérapie, centre Oscar-Lambret, ONCOLille, université de Lille, 3, rue Frédéric-Combemale, 59000 Lille, France.
authors.forename: É
authors.initials: É
authors.lastname: Lartigau
authors.affiliation: Département de radiothérapie, CHU Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Lagrange
authors.affiliation: Inserm, UMR1052, centre de recherches en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France. Electronic address: nicolas.foray@inserm.fr.
authors.forename: N
authors.initials: N
authors.lastname: Foray
mesh_terms: D004260:DNA Repair / Q000528:radiation effects*; D019583:Dose Fractionation, Radiation; D011829:Radiation Dosage; D013997:Time Factors
keywords: Cassures double-brin; DNA double-strand breaks; DNA repair; Fractionation; Fractionnement; Radiosensibilité; Radiosensitivity; Repeated doses; Réparation de l’ADN; Répétition de doses