title: Synthesis of highly substituted γ-hydroxybutenolides through the annulation of keto acids with alkynes and subsequent hydroxyl transposition.
abstract: An efficient synthesis of highly functionalized γ-hydroxybutenolides through BF3-catalyzed annulation of keto acids with alkynes is described. Many advantages such as the use of routine reagents, easy operation, and a 100% atom efficiency are demonstrated in the method. The reaction can be readily scaled up to gram quantities, offering good practicality.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China. chzhu@suda.edu.cn.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Mao
authors.forename: Chen
authors.initials: C
authors.lastname: Zhu