title: Arterial Spin-labeling in Central Nervous System Infection.
abstract: OBJECTIVE
  To investigate the characteristics of arterial spin-labeling magnetic resonance imaging (ASL-MRI) in central nervous system (CNS) infection.
  
  
  METHODS
  Thirty-two patients with CNS infections underwent a pulsed ASL-MRI. The findings on ASL-MRI were retrospectively assessed for the pathogens as well as each of the following four pathology classified based on conventional MRI findings: non-purulent parenchymal involvement, meningeal involvement, abscess formation, and ventricular involvement.
  
  
  RESULTS
  Among the 17 patients with non-purulent parenchymal involvement, ASL-MRI revealed high perfusion in 8 patients (47%) and low perfusion 1 patient (6%). Especially, four of five patients (80%) with definite or suspected herpes simplex virus (HSV) infection showed high perfusion on ASL-MRI. Seventeen of 22 patients (77%) with meningeal involvement showed high perfusion along the cerebral sulci irrespective of the pathogens. Meanwhile, 4 of 16 lesions (25%) with abscess formation showed low perfusion and one of six patients (17%) with ventricular involvement had high perfusion.
  
  
  CONCLUSIONS
  The characteristics of ASL-MRI in CNS infections were clearly delineated. ASL-MRI could be helpful for monitoring the brain function in CNS infections noninvasively.
authors.affiliation: Department of Radiology, National Center for Global Health and Medicine.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Noguchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yakushiji
authors.forename: Masashi
authors.initials: M
authors.lastname: Nishihara
authors.forename: Osamu
authors.initials: O
authors.lastname: Togao
authors.forename: Koji
authors.initials: K
authors.lastname: Yamashita
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Muneaki
authors.initials: M
authors.lastname: Matsuo
authors.forename: Shinya
authors.initials: S
authors.lastname: Azama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Irie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001922:Brain Abscess / Q000000981:diagnostic imaging; D002494:Central Nervous System Infections / Q000000981:diagnostic imaging*; D058565:Cerebral Ventriculitis / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004660:Encephalitis / Q000000981:diagnostic imaging; D018792:Encephalitis, Viral / Q000000981:diagnostic imaging; D005260:Female; D006561:Herpes Simplex / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008581:Meningitis / Q000000981:diagnostic imaging; D008587:Meningitis, Viral / Q000000981:diagnostic imaging; D008875:Middle Aged; D012189:Retrospective Studies; D013113:Spin Labels; D055815:Young Adult
chemical_list: D013113:Spin Labels