title: Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis.
abstract: BACKGROUND
  Studies on the relation between aldosterone synthase -344 T/C polymorphism and diabetic nephropathy showed controversial conclusions. This meta-analysis aimed to systematically summarize the association between aldosterone synthase (CYP11B2) gene polymorphism and diabetic nephropathy risk.
  
  
  METHODS
  Embase, PubMed, ScienceDirect, Web of Science, Wanfang Data, VIP Database, China Knowledge Resource Integrated Database and SinoMed have been searched. A total of five studies including 825 cases and 910 controls were included.
  
  
  RESULTS
  In overall analysis, significant increased risk was found in recessive comparison (OR = 1.27, 95% CI 1.05-1.55), homozygote comparison (OR = 1.39, 95% CI 1.04-1.88) and allele comparison (OR = 1.20, 95% CI = 1.05-1.39). No significant association was detected in dominant comparison (OR = 1.27, 95% CI 0.97-1.66) and heterozygote comparison (OR = 1.17, 95% CI 0.88-1.56). In subgroup analysis, significant increased risk existed in Asian population in allele comparison (OR = 1.45, 95% CI = 1.17-1.79), dominant comparison (OR = 1.78, 95% CI 1.11-2.87), homozygote comparison (OR = 2.11, 95% CI 1.29-3.47), recessive comparison (OR = 1.54, 95% CI 1.17-2.03), except for heterozygote comparison (OR = 1.44, 95% CI 0.87-2.38).
  
  
  CONCLUSIONS
  Our meta-analysis indicates that aldosterone synthase (CYP11B2) gene polymorphism may contribute to diabetic nephropathy development, especially in Asian group, with the T allele acting as a risk factor.
authors.affiliation: The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Xu
authors.affiliation: The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China wangxunjzy@163.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Liu
authors.affiliation: The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Shao
authors.affiliation: The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: He
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000201:enzymology* / Q000235:genetics*; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D019405:Cytochrome P-450 CYP11B2
keywords: Aldosterone synthase; CYP11B2; diabetic nephropathy; meta-analysis; polymorphism; risk