title: Cortical contributions to the auditory frequency-following response revealed by MEG.
abstract: The auditory frequency-following response (FFR) to complex periodic sounds is used to study the subcortical auditory system, and has been proposed as a biomarker for disorders that feature abnormal sound processing. Despite its value in fundamental and clinical research, the neural origins of the FFR are unclear. Using magnetoencephalography, we observe a strong, right-asymmetric contribution to the FFR from the human auditory cortex at the fundamental frequency of the stimulus, in addition to signal from cochlear nucleus, inferior colliculus and medial geniculate. This finding is highly relevant for our understanding of plasticity and pathology in the auditory system, as well as higher-level cognition such as speech and music processing. It suggests that previous interpretations of the FFR may need re-examination using methods that allow for source separation.
authors.affiliation: Montreal Neurological Institute, McGill University, Montreal, Québec, Canada H3A 2B4.|Centre for Research on Brain, Language and Music (CRBLM), Montreal, Québec, Canada H3G 2A8.|International Laboratory for Brain, Music, and Sound Research (BRAMS), Montreal, Québec, Canada.
authors.forename: Emily B J
authors.initials: EB
authors.lastname: Coffey
authors.affiliation: Montreal Neurological Institute, McGill University, Montreal, Québec, Canada H3A 2B4.|Centre for Research on Brain, Language and Music (CRBLM), Montreal, Québec, Canada H3G 2A8.|International Laboratory for Brain, Music, and Sound Research (BRAMS), Montreal, Québec, Canada.|German Center for Neurodegenerative Diseases (DZNE), Bonn 53175, Germany.
authors.forename: Sibylle C
authors.initials: SC
authors.lastname: Herholz
authors.affiliation: Montreal Neurological Institute, McGill University, Montreal, Québec, Canada H3A 2B4.
authors.forename: Alexander M P
authors.initials: AM
authors.lastname: Chepesiuk
authors.affiliation: Montreal Neurological Institute, McGill University, Montreal, Québec, Canada H3A 2B4.|Centre for Research on Brain, Language and Music (CRBLM), Montreal, Québec, Canada H3G 2A8.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Baillet
authors.affiliation: Montreal Neurological Institute, McGill University, Montreal, Québec, Canada H3A 2B4.|Centre for Research on Brain, Language and Music (CRBLM), Montreal, Québec, Canada H3G 2A8.|International Laboratory for Brain, Music, and Sound Research (BRAMS), Montreal, Québec, Canada.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zatorre
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001519:Behavior; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008959:Models, Neurological; D012535:Scalp / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors; D055815:Young Adult