title: Hyperjapones A-E, Terpenoid Polymethylated Acylphloroglucinols from Hypericum japonicum.
abstract: Hyperjapones A-E (1-5), novel terpenoid polymethylated acylphloroglucinols (TPAPs) with unusual architectures, were characterized from Hypericum japonicum. Their structures and absolute configurations were determined by comprehensive spectroscopic data and X-ray diffractions. Compound 1 was obtained as a racemic mixture and was separated by a column coated with cellulose tris(4-methylbenzoate) after attempts with various chiral materials. Compounds 1, 2, and 4 exhibited moderate antitumor activities in vitro.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors.forename: Xing-Wei
authors.initials: XW
authors.lastname: Yang
authors.affiliation: Research Center for Biotransformation of Medicinal Plants, Yunnan University of Traditional Chinese Medicine , Kunming 650500, People's Republic of China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Su
authors.affiliation: Research Center for Biotransformation of Medicinal Plants, Yunnan University of Traditional Chinese Medicine , Kunming 650500, People's Republic of China.
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001565:Benzoates; D045744:Cell Line, Tumor; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010696:Phloroglucinol / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D061065:Polyketides; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001565:Benzoates; D010936:Plant Extracts; D061065:Polyketides; D013729:Terpenes; C000611016:hyperjapone; C090722:tris(4-methylbenzoate)cellulose; D002482:Cellulose; D010696:Phloroglucinol