title: Production of Quaternary α-Aminonitriles by Means of Indium-Catalyzed Three-Component Reaction of Alkynes, Amines, and Trimethylsilyl Cyanide.
abstract: A novel synthesis of α-aminonitriles is described via an indium-catalyzed three-component coupling reaction of alkynes, amines, and trimethylsilyl cyanide (Me3SiCN). Hydroamination of alkynes with a subsequent nucleophilic addition of Me3SiCN resulted in a novel approach to quaternary α-aminonitrile derivatives.
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI) , Noda, Chiba 278-8510, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Hamachi
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI) , Noda, Chiba 278-8510, Japan.
authors.forename: Moe
authors.initials: M
authors.lastname: Katano
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI) , Noda, Chiba 278-8510, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ogiwara
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI) , Noda, Chiba 278-8510, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Sakai