title: Increased levels of oxidative stress biomarkers in metal oxides nanomaterial-handling workers.
abstract: This study assessed oxidatively damaged DNA and antioxidant enzyme activity in workers occupational exposure to metal oxides nanomaterials. Exposure to TiO2, SiO2, and ITO resulted in significant lower antioxidant enzymes (glutathione peroxidase and superoxide dismutase) and higher oxidative biomarkers 8-hydroxydeoxyguanosine (8-oxodG) than comparison workers. Statistically significant correlations were noted between plasma and urine 8-oxodG, between white blood cells (WBC) and urine 8-oxodG, and between WBC and plasma 8-oxodG. In addition, there were significant negative correlations between WBC 8-oxodG and SOD and between urinary 8-oxodG and GPx levels. The results showed that urinary 8-oxodG may be considered to be better biomarker.
authors.affiliation: a National Institute of Environmental Health Sciences , National Health Research Institutes , Zhunan , Miaoli County , Taiwan ;
authors.forename: Saou-Hsing
authors.initials: SH
authors.lastname: Liou
authors.affiliation: b Department of Chemistry , Fu Jen Catholic University , New Taipei City , Taiwan.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Chen
authors.affiliation: a National Institute of Environmental Health Sciences , National Health Research Institutes , Zhunan , Miaoli County , Taiwan ;
authors.forename: Hui-Yi
authors.initials: HY
authors.lastname: Liao
authors.affiliation: a National Institute of Environmental Health Sciences , National Health Research Institutes , Zhunan , Miaoli County , Taiwan ;
authors.forename: Chien-Jen
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: b Department of Chemistry , Fu Jen Catholic University , New Taipei City , Taiwan.
authors.forename: Jhih-Sheng
authors.initials: JS
authors.lastname: Chen
authors.affiliation: b Department of Chemistry , Fu Jen Catholic University , New Taipei City , Taiwan.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Lee
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000975:Antioxidants; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood / Q000652:urine; D006801:Humans; D049329:Nanostructures / Q000009:adverse effects; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress; D010087:Oxides / Q000009:adverse effects*; D010088:Oxidoreductases / Q000097:blood / Q000652:urine
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010087:Oxides; D000080242:8-Hydroxy-2'-Deoxyguanosine; D010088:Oxidoreductases; D003849:Deoxyguanosine
keywords: 8-hydroxydeoxyguanosine; Antioxidant enzyme activities; LC-MS/MS; biomarkers; metal oxides nanomaterials