title: Management of Atypical and Anaplastic Meningiomas.
abstract: Meningiomas are the most prevalent primary tumor of central nervous system origin and, although most neoplasms are benign, a small proportion exemplifies an aggressive profile characterized by high recurrence rates, pleomorphic histology, and overall resistance to standard treatment. Standard initial therapy for malignant meningiomas includes maximal safe surgical resection followed by focal radiation in certain cases. The role for chemotherapy during recurrence of these aggressive meningiomas is less clear. Prognosis is poor and recurrence of malignant meningiomas is high. This article provides an overview of atypical and anaplastic malignant meningiomas, their treatment, and ongoing research for more effective treatments.
authors.affiliation: Department of Neurosurgery, University of Miami, 2nd Floor, 1095 Northwest 14 Terrace D4-6, Miami, FL 33136, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Buttrick
authors.affiliation: Department of Neurosurgery, University of Miami, 2nd Floor, 1095 Northwest 14 Terrace D4-6, Miami, FL 33136, USA.
authors.forename: Ashish H
authors.initials: AH
authors.lastname: Shah
authors.affiliation: Department of Neurosurgery, University of Miami, 2nd Floor, 1095 Northwest 14 Terrace D4-6, Miami, FL 33136, USA.
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Komotar
authors.affiliation: Department of Neurosurgery, University of Miami, 2nd Floor, 1095 Northwest 14 Terrace D4-6, Miami, FL 33136, USA. Electronic address: MIvan@med.miami.edu.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Ivan
mesh_terms: D001918:Brachytherapy / Q000379:methods; D018572:Disease-Free Survival; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008579:Meningioma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome
keywords: Anaplastic meningioma; Atypical meningioma; Chemotherapy; Malignant meningioma; Radiation therapy; Recurrence