title: Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH.
abstract: An activatable photoacoustic nanoprobe based on a semiconducting oligomer with amplified brightness and pH-sensing capability is developed by taking advantage of nanodoping to simultaneously create both intraparticle photoinduced electron transfer and intramolecular protonation within a single particle. This organic nanoprobe permits noninvasive real-time ratiometric photoacoustic imaging of pH in tumors in living mice through systemic administration at a relatively low dosage.
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 637457, Singapore.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Miao
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 637457, Singapore.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lyu
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, P. R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ding
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 637457, Singapore.
authors.forename: Kanyi
authors.initials: K
authors.lastname: Pu
keywords: activatable probes; photoacoustic imaging; semiconducting polymer nanoparticles