title: Inflammation: Species-specific TLR signalling -- insight into human disease.
abstract: The selective utilization of IRAK kinases, which are thought to be recruited to MyD88 to form the ‘Myddosome’, has been shown to differ substantially in mouse and human cells. This finding has important implications for the development of therapeutics for inflammatory and autoimmune disorders associated with Toll-like receptors.
authors.affiliation: Department of Microbiology and Immunology, University of Maryland, School of Medicine, 685 W. Baltimore Street, Suite 380, Baltimore, Maryland 21201, USA.
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Perkins
authors.affiliation: Department of Microbiology and Immunology, University of Maryland, School of Medicine, 685 W. Baltimore Street, Suite 380, Baltimore, Maryland 21201, USA.
authors.forename: Stefanie N
authors.initials: SN
authors.lastname: Vogel
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation; D053592:Interleukin-1 Receptor-Associated Kinases; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors
chemical_list: D051193:Toll-Like Receptors; D053592:Interleukin-1 Receptor-Associated Kinases