title: A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc.
abstract: Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan. In our phytochemical investigations on this genus, a new megastigmane sesquiterpenoid, which is referred to as schinifolenol A (1), was isolated from Z. schinifolium. The stereochemistry was characterized via the analyses of extensive spectra. The absolute configuration was established by the application of a modified Mosher's experiment and assisted by a time-dependent density functional theory (TD-DFT) on calculated electronic circular dichroism (ECD). Bioactivity screenings showed that compound 1 exhibited a safe hypotoxicity and a better selectivity on anti-Kaposi's sarcoma associated herpes virus (KSHV).
authors.affiliation: Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China. hlz198@126.com.|Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. hlz198@126.com.
authors.forename: Linzhen
authors.initials: L
authors.lastname: Hu
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. cs18379135010@163.com.
authors.forename: Kongchao
authors.initials: K
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. wzz75283@163.com.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. junjun.liu@hust.edu.cn.
authors.forename: Junjun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. wkpzcq@163.com.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Wang
authors.affiliation: Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. tjzhangjinwen@163.com.
authors.forename: Jinwen
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. luozengwei@hust.edu.cn.
authors.forename: Zengwei
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. yongboxue@hust.edu.cn.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China. zhangyh@mails.tjmu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. whxhzy@163.com.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D002942:Circular Dichroism; D003512:Cyclohexanones / Q000008:administration & dosage* / Q000737:chemistry; D005960:Glucosides / Q000008:administration & dosage* / Q000737:chemistry; D019288:Herpesvirus 8, Human / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D015394:Molecular Structure; D045792:Norisoprenoids / Q000008:administration & dosage* / Q000737:chemistry; D064209:Phytochemicals / Q000008:administration & dosage / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000821:virology; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D003512:Cyclohexanones; D005960:Glucosides; D045792:Norisoprenoids; D064209:Phytochemicals; D010936:Plant Extracts; C413264:megastigmane
keywords: Kaposi’s sarcoma associated herpes virus; megastigmane; sesquiterpenoid; zanthoxylum schinifolium