title: IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers.
abstract: BACKGROUND
  Healthcare workers constitute a population at high risk for HBV infection. Efficient vaccination options are available; however, the individual response to HBV vaccination may vary widely between subjects, potentially due to cytokine profiles and genetic variations. In the present study, we investigated the relationship between IL-17 and IL-22 gene polymorphisms versus non- and low-responsiveness to HBV vaccination in healthcare workers.
  
  
  METHODS
  We selected the following IL-17 and IL-22 polymorphisms: rs4711998 (A/G) from IL-17 and rs2227501 (A/T), rs2227503 (A/G), rs1026786 (A/G) from IL-22 sequences genes. These were determined by polymerase chain reaction restriction fragment length polymorphisms.
  
  
  RESULTS
  The IL-17 rs4711998 GG genotype had a significantly lower frequency in non-responders compared to low-responders (p=0.025). However, we did not identify a relationship between IL-22 rs1026780, rs2227501 and rs2227503 genotypes and the anti-HBs response following HBV vaccination.
  
  
  CONCLUSIONS
  These data suggest that genetic variation in rs4711998 polymorphisms in the IL-17 cytokine may influence vaccine-induced immune responses to HBV vaccine in healthcare workers.
authors.affiliation: PhD student, Department of Infectious Diseases, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Immunology and Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Borzooy
authors.affiliation: MD, PhD, Department of Infectious Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; National Institute of Infectious Diseases, "Prof. Dr. Matei Balş", Bucharest, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Streinu-Cercel
authors.affiliation: Ms, PhD, Head of the department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Abbass
authors.initials: A
authors.lastname: Mirshafiey
authors.affiliation: Bs, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Khamseh
authors.affiliation: Bs, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Masoud Karkhaneh
authors.initials: MK
authors.lastname: Mahmoudie
authors.affiliation: Ms, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shadi Sadat
authors.initials: SS
authors.lastname: Navabi
authors.affiliation: Bs, Department of Infection Control, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Nosrati
authors.affiliation: Ms, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Najafi
authors.affiliation: Ms, PhD, Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hosseini
authors.affiliation: MD, PhD, Clinical Virologist, Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Jazayeri
keywords: HBV vaccine; IL-17; IL-22; gene polymorphisms; healthcare workers