title: Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances.
abstract: Asthma and chronic rhinosinusitis are heterogeneous airway diseases of the lower and upper airways, respectively. Molecular and cellular studies indicate that these diseases can be categorized into unique endotypes, which have therapeutic implications. One such endotype is aspirin-exacerbated respiratory disease (AERD), which encompasses the triad of asthma, aspirin (or nonsteroidal anti-inflammatory drug) hypersensitivity, and nasal polyposis. AERD has unique pathophysiological features that distinguish it from aspirin-tolerant asthma and other forms of chronic rhinosinusitis. This review details molecular and cellular features of AERD and highlights current and future therapies that are based on these insights.
authors.affiliation: Asthma and Allergic Disease Center, Carter Immunology Center, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Steinke
authors.affiliation: Asthma and Allergic Disease Center, Carter Immunology Center, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: Jeff M
authors.initials: JM
authors.lastname: Wilson
keywords: arachidonic acid; aspirin-exacerbated respiratory disease; cyclooxygenase; leukotriene; prostaglandin