title: Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup.
abstract: Secretory meningiomas (SM) represent a rare variant of the most common benign intracranial brain tumor. Defined by the histologic appearance of eosinophilic glandular formations and periodic-acidic Schiff-positive pseudopsammoma bodies, SM are characterized by unique molecular alterations, a disproportional occurrence of reactive peritumoral brain edema, and a clinical course that demands for increased awareness for perioperative complications. The frequent presence of extensive peritumoral edema has become a hallmark of SM and can be associated with life-threatening complications. The exact pathophysiology of edema formation in SM is still unknown.
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: Malte
authors.initials: M
authors.lastname: Mohme
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: Pedram
authors.initials: P
authors.lastname: Emami
authors.affiliation: Department of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: Jakob
authors.initials: J
authors.lastname: Matschke
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Regelsberger
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Westphal
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr. 52, Hamburg 20246, Germany. Electronic address: s.eicker@uke.de.
authors.forename: Sven Oliver
authors.initials: SO
authors.lastname: Eicker
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000628:therapy*
keywords: Edema; Management; Meningioma; Secretory