title: Synthesis and characterization of antibacterial carboxymethyl Chitosan/ZnO nanocomposite hydrogels.
abstract: The antibacterial carboxymethyl chitosan/ZnO nanocomposite hydrogels were successfully prepared via in situ formation of ZnO nanorods in the crosslinked carboxymethyl chitosan (CMCh) matrix, by treating the CMCh hydrogel matrix with zinc nitrate solution followed by the oxidation of zinc ions with alkaline solution. The resulting CMCh/ZnO hydrogels were characterized by using FTIR spectroscopy, X-ray diffractormetry and scanning electron microscopy (SEM). SEM micrographs revealed the formation of ZnO nanorods in the hydrogel matrix with the size ranging from 190nm to 600nm. The swelling behavior of the prepared nanocomposite hydrogels was also investigated in different pH solutions. The CMCh/ZnO nanocomposite hydrogel showed rather higher swelling behavior in different pH solutions in comparison with neat CMCh hydrogel. Furthermore, the antibacterial activity of CMCh/ZnO hydrogel was studied against Escherichia coli and Staphylococcus aureus by CFU assay. The results demonstrated an excellent antibacterial activity of the nanocomposite hydrogel. Therefore, the developed CMCh/ZnO nanocomposite hydrogel can be used effectively in biomedical field.
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, No. 29, 13th Ave., TEDA, Tianjin 300457, China.
authors.forename: Fazli
authors.initials: F
authors.lastname: Wahid
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, No. 29, 13th Ave., TEDA, Tianjin 300457, China.
authors.forename: Jun-Jiao
authors.initials: JJ
authors.lastname: Yin
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology (Ministry of Education), Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Xue
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, No. 29, 13th Ave., TEDA, Tianjin 300457, China.
authors.forename: Han
authors.initials: H
authors.lastname: Xue
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, No. 29, 13th Ave., TEDA, Tianjin 300457, China.
authors.forename: Yu-Shi
authors.initials: YS
authors.lastname: Lu
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology (Ministry of Education), Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhong
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, No. 29, 13th Ave., TEDA, Tianjin 300457, China. Electronic address: chuliqiang@tust.edu.cn.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Chu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; C514968:carboxymethyl-chitosan; D048271:Chitosan; D015034:Zinc Oxide
keywords: Antibacterial activity; Carboxymethyl chitosan; Hydrogel