title: Prognosis and response to laser treatment of early-onset hypertrophic port-wine stains (PWS).
abstract: BACKGROUND
  There is limited information regarding early development of soft-tissue and/or bone hypertrophy with facial port-wine stains (PWS).
  
  
  OBJECTIVE
  We sought to characterize patients with hypertrophic PWS presenting during childhood.
  
  
  METHODS
  Patients with a facial PWS and underlying hypertrophy that developed before the age of 18 years were included in a multicenter retrospective study. Age at onset of the hypertrophy, its location, association with odontologic problems, presence of other associated complications, and response to laser treatment were recorded.
  
  
  RESULTS
  A total of 98 patients were included. The mean age at onset of hypertrophy, retrieved for 77 of 98 patients, was 5.6 years. The hypertrophy was congenital in 26%. Odontologic problems were noted in 39.8% of cases. Other complications, including cataract, asymmetric development of the maxillary bone, and speech delay/disorders, were reported in 18.4%. In all, 67 patients received laser treatment. Only 3% achieved complete or nearly complete clearance of the PWS.
  
  
  CONCLUSIONS
  As only cases of PWS with early-onset hypertrophy were included, we were unable to calculate the prevalence of this manifestation.
  
  
  CONCLUSIONS
  PWS with early-onset hypertrophy are associated with a high rate of complications and a poor response to laser treatment. Periodic monitoring is recommended for early detection and treatment of complications.
authors.affiliation: Department of Dermatology of Nice, University Hospital of Nice, Nice, France; Institut National de Santé et de Recherche Médicale (INSERM) U1065, Team 12, C3M, Nice, France. Electronic address: passeron@unice.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Passeron
authors.affiliation: Department of Dermatology of Alger, University Hospital of Alger, Alger, Algeria.
authors.forename: Aicha
authors.initials: A
authors.lastname: Salhi
authors.affiliation: Centre Laser International de la Peau, Paris, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Mazer
authors.affiliation: Department of Dermatology of Lille, University Hospital of Lille, Lille, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Lavogiez
authors.affiliation: Department of Dermatology of Toulouse, University Hospital of Toulouse, Toulouse, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Mazereeuw-Hautier
authors.affiliation: Laser Center, Paris, France.
authors.forename: Chrystèle
authors.initials: C
authors.lastname: Galliot
authors.affiliation: Department of Dermatology of Marseille, University Hospital of Marseille, Marseille, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Collet-Villette
authors.affiliation: Department of Dermatology of Bordeaux, University Hospital of Bordeaux, Bordeaux, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Labreze
authors.affiliation: Center for Vascular Anomalies, Division of Plastic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Boon
authors.affiliation: Center for Vascular Anomalies, Division of Plastic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Hardy
authors.affiliation: Laser Center, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Fayard
authors.affiliation: Department of Dermatology of Toulouse, University Hospital of Toulouse, Toulouse, France.
authors.forename: Cristina Bulai
authors.initials: CB
authors.lastname: Livideanu
authors.affiliation: Laser Center, Rennes, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Toubel
authors.affiliation: Department of Dermatology of Tours, University Hospital of Tours, Tours, France.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Georgescou
authors.affiliation: Laser Center, Grenoble, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Gral
authors.affiliation: Department of Dermatology of Toulouse, University Hospital of Toulouse, Toulouse, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Maza
authors.affiliation: Department of Dermatology of Nice, University Hospital of Nice, Nice, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Lacour
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005145:Face; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000151:congenital / Q000473:pathology / Q000601:surgery; D007223:Infant; D054025:Lasers, Dye / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009333:Neck; D019339:Port-Wine Stain / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: complications; hypertrophic; laser; odontologic problems; port-wine stains; speech delay