title: Anti-infectives for systemic use prescribed in a Spanish hospital between 2009-2013.
abstract: The overuse and misuse of antimicrobials contribute to the emergence of antibiotic-resistant bacteria. The aim of this work was to analyse all the anti-infectives for systemic use (J ATC group) prescribed at the University Clinic Hospital of Valladolid (Spain) for the years 2009-2013. Amounts of anti-infectives (antibacterials, antifungals and antivirals) used in the period 2009-2013 were expressed as defined daily doses (DDDs) and as total expenditure, and the significance of the difference in consumption of anti-infectives and the relevant expenditure between years was evaluated from the overlapping of the corresponding confidence intervals at 95% confidence level of DDDs and expenditure. The results obtained showed that DDDs and expenditure of antibacterials decreased in the period 2009-2013. Antimycotics showed an upward trend in expenditure and DDDs in the five-year study period, but with major oscillations. The consumption of antivirals was practically constant in the period 2009-2011; in 2012, a significant reduction was observed and this reduction was conserved in 2013, although their expenditure increased year by year. In conclusion, in the period 2009-2013, expenditure on anti-infectives increased year to year. However, this increase in expenditure resulted in a downward trend of DDDs.
authors.affiliation: Service of Microbiology and Immunology, University Clinic Hospital of Valladolid, Spain.
authors.forename: Gabriel Alberto
authors.initials: GA
authors.lastname: March Rosselló
authors.affiliation: Faculty of Medicine, University of Valencia, Spain.
authors.forename: Arturo Artero
authors.initials: AA
authors.lastname: Mora
authors.affiliation: Management of the University Clinic Hospital of Valladolid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pérez Rubio
authors.affiliation: Management of the University Clinic Hospital of Valladolid, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Eiros Bouza
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D012189:Retrospective Studies; D013030:Spain
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents