title: Genomic Aberrations Drive Clonal Evolution of Neuroendocrine Tumors.
abstract: Molecular features of castration-resistant neuroendocrine prostate cancer (CRPC-NE) are not well characterized. A recent study that investigated genomic aberrations of CRPC-NE tumors suggests their clonal evolution from CRPC adenocarcinoma. Furthermore, the existence of a distinct DNA methylation profile in CRPC-NE implicates a critical role for epigenetic modification in the development of CRPC-NE.
authors.affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Akash Kumar
authors.initials: AK
authors.lastname: Kaushik
authors.affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: sreekuma@bcm.edu.
authors.forename: Arun
authors.initials: A
authors.lastname: Sreekumar
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000818:Animals; D015415:Biomarkers; D060965:Clonal Evolution / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D008297:Male; D018358:Neuroendocrine Tumors / Q000235:genetics*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000235:genetics*
chemical_list: D015415:Biomarkers
keywords: DNA methylation; adenocarcinoma; genomic aberrations; molecular biomarker; neuroendocrine; prostate cancer