title: Neural signature of food reward processing in bulimic-type eating disorders.
abstract: Clinical observations and similarities to addiction suggest heightened reward sensitivity to food in patients with bulimic-type eating (BTE) disorders. Therefore, we investigated the expectation and receipt of food reward compared with monetary reward in patients with BTE. Fifty-six patients with BTE (27 patients with binge eating disorder and 29 with bulimia nervosa) and 55 matched healthy control participants underwent event-related functional magnetic resonance imaging while performing both food and monetary incentive delay tasks. BTE patients exhibited reduced brain activation in the posterior cingulate cortex during the expectation of food and increased activity in the medial orbitofrontal cortex, anterior medial prefrontal cortex and posterior cingulate cortex during the receipt of food reward. These findings were relevant to food because we found no significant group differences related to monetary reward. In the patients, higher brain activity in the medial orbitofrontal cortex during the receipt of food reward was related to higher levels of trait food craving and external eating. BTE patients exhibited increased hedonic processing during the receipt of food reward. These findings corroborate the notion that an altered responsiveness of the reward network to food stimuli is associated with BTE.
authors.affiliation: Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany Department of Psychosomatic Medicine and Psychotherapy Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany joe.simon@med.uni-heidelberg.de.
authors.forename: Joe J
authors.initials: JJ
authors.lastname: Simon
authors.affiliation: Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Mandy
authors.initials: M
authors.lastname: Skunde
authors.affiliation: Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany Department of General Adult Psychiatry, Centre for Psychosocial Medicine, Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Walther
authors.affiliation: Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Bendszus
authors.affiliation: Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Herzog
authors.affiliation: Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany Department of Psychosomatic Medicine and Psychotherapy Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Friederich
mesh_terms: D000328:Adult; D056912:Binge-Eating Disorder / Q000523:psychology; D001931:Brain Mapping; D002032:Bulimia / Q000523:psychology*; D005260:Female; D005502:Food; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D006815:Hunger; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012201:Reward; D055815:Young Adult
keywords: binge eating disorder; bulimia nervosa; functional MRI; medial orbitofrontal cortex; posterior cingulate cortex; reward processing