title: Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs.
abstract: To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm(2) of endometrium nor in the height of the uterine epithelium.
authors.affiliation: Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina.
authors.forename: Tamara
authors.initials: T
authors.lastname: Ponchon
authors.affiliation: Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina.
authors.forename: Mariana
authors.initials: M
authors.lastname: Lopez Merlo
authors.affiliation: Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina.
authors.forename: Marcela
authors.initials: M
authors.lastname: Faya
authors.affiliation: Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Priotto
authors.affiliation: Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina.
authors.forename: Claudio
authors.initials: C
authors.lastname: Barbeito
authors.affiliation: Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gobello
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002987:Clitoris / Q000187:drug effects; D004285:Dogs; D004848:Epithelium / Q000187:drug effects*; D005260:Female; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D012741:Sexual Maturation / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
chemical_list: D017258:Medroxyprogesterone Acetate
keywords: canid; contraception; endocrine disruption; genital tract; neonatal