title: Prevalence of Hepatotoxicity From Antituberculosis Therapy: A Five-Year Experience From South India.
abstract: Antituberculosis (ATT) drug-induced liver injury (DILI) is a common and serious adverse effect of tuberculosis (TB) treatment. This retrospective study was carried out to study the prevalence of DILI among patients who had received anti-TB medications and to study some of the known risk factors responsible for causing DILI.
  
  
  
  This longitudinal descriptive study was performed to evaluate cases of DILI with predefined criteria. Patients of all ages, diagnosed and treated for smear positive pulmonary TB from January 1, 2008 to December 31, 2012 and those who came for regular follow-up were included in the study. Multiple logistic regression analysis was performed to determine the association of different risk factors and DILI. The confounders considered were age, sex, weight, body mass index, doses of drugs (fixed or per kg), ATT regimens (daily or intermittent), and treatment categories.
  
  
  
  Of the 253 patients analyzed, 24 (9.48%) developed DILI. Associations of different risk factors were insignificant; including chronic alcohol consumption, hepatitis B infection, hepatitis C infection, HIV infection, and existing chronic TB.
  
  
  
  DILI was not significantly associated with known risk factors in our settings.
authors.affiliation: Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Arunava
authors.initials: A
authors.lastname: Saha
authors.affiliation: Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Margaret
authors.initials: M
authors.lastname: Shanthi F X
authors.affiliation: Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Blessed
authors.initials: B
authors.lastname: Winston A
authors.affiliation: Christian Medical College, Vellore, Tamil Nadu, India saibaldas123@gmail.com.
authors.forename: Saibal
authors.initials: S
authors.lastname: Das
authors.affiliation: Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Aniket
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Joy S
authors.initials: JS
authors.lastname: Michael
authors.affiliation: Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: T
authors.initials: T
authors.lastname: Balamugesh
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007194:India; D016015:Logistic Models; D008137:Longitudinal Studies; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
keywords: antituberculosis (ATT) drugs; drug-induced liver injury (DILI); hepatotoxicity; liver function; pulmonary tuberculosis (TB)