title: SORCS1 polymorphism and insulin secretion in obese women with polycystic ovary syndrome.
abstract: We investigated the influence of SORCS1 polymorphisms on insulin secretion in obese women with PCOS. Metabolic status was recorded in 50 clinically well characterized PCOS patients. Oral glucose tolerance test was performed and laboratory parameters of insulin resistance measured. All patients were genotyped for SORCS1 rs1358030, rs1416406 and rs11192966 polymorphisms. Statistical analysis was performed using the Mann-Whitney test. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels (p = 0.006) and increased glucose stimulated insulin secretion (p = 0.034). None of the polymorphisms influenced insulin resistance as measured by homeostatic model assessment. We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin secretion in obese women with PCOS.
authors.affiliation: a Pharmacogenetics Laboratory, Institute of Biochemistry, University of Ljubljana , Ljubljana , Slovenia .
authors.forename: Ana
authors.initials: A
authors.lastname: Hrovat
authors.affiliation: b Department of Endocrinology , Diabetes and Metabolic Diseases, University Medical Center Ljubljana , Ljubljana , Slovenia and.
authors.forename: Nika Aleksandra
authors.initials: NA
authors.lastname: Kravos
authors.affiliation: a Pharmacogenetics Laboratory, Institute of Biochemistry, University of Ljubljana , Ljubljana , Slovenia .
authors.forename: Katja
authors.initials: K
authors.lastname: Goričar
authors.affiliation: b Department of Endocrinology , Diabetes and Metabolic Diseases, University Medical Center Ljubljana , Ljubljana , Slovenia and.
authors.forename: Mojca
authors.initials: M
authors.lastname: Jensterle Sever
authors.affiliation: b Department of Endocrinology , Diabetes and Metabolic Diseases, University Medical Center Ljubljana , Ljubljana , Slovenia and.|c Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia.
authors.forename: Andrej
authors.initials: A
authors.lastname: Janež
authors.affiliation: a Pharmacogenetics Laboratory, Institute of Biochemistry, University of Ljubljana , Ljubljana , Slovenia .
authors.forename: Vita
authors.initials: V
authors.lastname: Dolžan
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000150:complications / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011956:Receptors, Cell Surface; C472780:SORCS1 protein, human
keywords: Insulin resistance; SORCS1; polycystic ovary syndrome; polymorphism