title: Restoration of Cone Interdigitation Zone Associated With Improvement of Focal Macular ERG After Fovea-Off Rhegmatogenous Retinal Reattachment.
abstract: OBJECTIVE
  To determine whether a correlation exists between the parameters of the focal macular ERGs (FMERGs) and the microstructural changes of the photoreceptors after successful surgery for fovea-off rhegmatogenous retinal detachment (RRD).
  
  
  METHODS
  Twenty eyes of 20 patients who had undergone successful surgery to reattach the retina in eyes with fovea-off RRD were studied. Focal macular ERGs and spectral-domain OCT (SD-OCT) were recorded at 1 and 6 months after the surgery. Changes of the components of the FMERGs, as well as changes of the SD-OCT parameters including the length of the external limiting membrane (ELM), ellipsoid zone (EZ), cone interdigitation zone (CIZ), and size of the outer photoreceptor area (between ELM and RPE), were determined.
  
  
  RESULTS
  During the postoperative period, the mean amplitudes of the a-waves increased by 1.4 times and the b-waves by 1.7 times. Spectral-domain OCT showed that the mean length of the EZ and CIZ and the size of the outer photoreceptor area had increased significantly at 6 months. The degree of the increase in the CIZ and outer photoreceptor area was significantly correlated with the increase in the amplitudes of the b-waves of the FMERGs (r = 0.56, P = 0.042, r = 0.57, P = 0.040, respectively; Spearman rank correlation test). However, the length of the EZ was not significantly correlated with the increase of the b-waves.
  
  
  CONCLUSIONS
  A restoration of the EZ alone might not be enough to improve the FMERGs, and a restoration of the EZ accompanied by that of the CIZ was essential for the recovery of the FMERGs after fovea-off RRD.
authors.forename: Azusa
authors.initials: A
authors.lastname: Kominami
authors.forename: Shinji
authors.initials: S
authors.lastname: Ueno
authors.forename: Taro
authors.initials: T
authors.lastname: Kominami
authors.forename: Ayami
authors.initials: A
authors.lastname: Nakanishi
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Piao
authors.forename: Eimei
authors.initials: E
authors.lastname: Ra
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yasuda
authors.forename: Tetsu
authors.initials: T
authors.lastname: Asami
authors.forename: Hiroko
authors.initials: H
authors.lastname: Terasaki
mesh_terms: D000328:Adult; D000368:Aged; D004596:Electroretinography; D058450:Endotamponade; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function / Q000502:physiology; D012038:Regeneration; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D012163:Retinal Detachment / Q000503:physiopathology / Q000601:surgery*; D012591:Scleral Buckling; D013459:Sulfur Hexafluoride / Q000008:administration & dosage; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D013459:Sulfur Hexafluoride