title: Distinct Neuropsychological Correlates in Positive and Negative Formal Thought Disorder Syndromes: The Thought and Language Disorder Scale in Endogenous Psychoses.
abstract: The correlation of formal thought disorder (FTD) symptoms and subsyndromes with neuropsychological dimensions is as yet unclear. Evidence for a dysexecutive syndrome and semantic access impairments has been discussed in positive FTD, albeit focusing mostly on patients with schizophrenia. We investigated the correlation of the full range of positive and negative as well as subjective and objective FTD with neuropsychological domains in different patient groups. Patients with ICD-10 schizophrenia (n = 51), depression (n = 51), and bipolar mania (n = 18), as well as healthy subjects (n = 60), were interviewed with the Rating Scale for the Assessment of Objective and Subjective Formal Thought and Language Disorder (TALD) and assessed using a multidimensional neuropsychological test battery (executive function, semantic and lexical verbal fluency, attention, working memory, and abstract thinking). Partial correlation analysis, controlling for age and word knowledge, revealed significant results for the objective positive FTD dimension and executive dysfunctions. Objective negative FTD was associated with deficits in lexico-semantic retrieval, as well as attention and working memory dysfunctions. The results suggest that different neuropsychological substrates correlate with the multidimensional and phenomenologically different FTD syndromes. FTD is a complex, multidimensional syndrome with a variety of neuropsychological impairments, which should be accounted for in future studies investigating the pathogenesis of FTD.
authors.affiliation: Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Nagels
authors.forename: Paul
authors.initials: P
authors.lastname: Fährmann
authors.forename: Mirjam
authors.initials: M
authors.lastname: Stratmann
authors.forename: Sayed
authors.initials: S
authors.lastname: Ghazi
authors.forename: Christian
authors.initials: C
authors.lastname: Schales
authors.forename: Michael
authors.initials: M
authors.lastname: Frauenheim
authors.forename: Lena
authors.initials: L
authors.lastname: Turner
authors.forename: Tobias
authors.initials: T
authors.lastname: Hornig
authors.forename: Michael
authors.initials: M
authors.lastname: Katzev
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Müller-Isberner
authors.forename: Michael
authors.initials: M
authors.lastname: Grosvald
authors.forename: Axel
authors.initials: A
authors.lastname: Krug
authors.forename: Tilo
authors.initials: T
authors.lastname: Kircher
mesh_terms: D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000523:psychology*; D000368:Aged; D001288:Attention; D001714:Bipolar Disorder / Q000523:psychology*; D003866:Depressive Disorder / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000523:psychology*; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000523:psychology; D012559:Schizophrenia; D012565:Schizophrenic Psychology; D012660:Semantics; D013064:Speech Disorders / Q000523:psychology*; D013850:Thinking; D055815:Young Adult