title: Linezolid-induced serotonin toxicity in a patient not taking monoamine oxidase inhibitors or serotonin receptor antagonists.
abstract: Linezolid is an oxazolidinone antibiotic with weak monoamine oxidase (MAO) type A and MAO type B inhibitory effects. Linezolid has been associated with serotonin toxicity when used concomitantly with multiple medications that are known to increase serotonin concentrations. We report the case of a 65-year-old woman with signs and symptoms of serotonin toxicity following administration of linezolid for treatment of methicillin-resistant Staphylococcus aureus pneumonia.
authors.affiliation: Department of Medicine, Oklahoma State University Medical Center, Tulsa, Oklahoma (Sutton); and Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma (Stroup, Som).
authors.forename: Jacob
authors.initials: J
authors.lastname: Sutton
authors.affiliation: Department of Medicine, Oklahoma State University Medical Center, Tulsa, Oklahoma (Sutton); and Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma (Stroup, Som).
authors.forename: Jeff
authors.initials: J
authors.lastname: Stroup
authors.affiliation: Department of Medicine, Oklahoma State University Medical Center, Tulsa, Oklahoma (Sutton); and Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma (Stroup, Som).
authors.forename: Mo
authors.initials: M
authors.lastname: Som