title: Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls.
abstract: Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xyh0709@ustc.edu.cn.
authors.forename: Ran
authors.initials: R
authors.lastname: Ding
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xyh0709@ustc.edu.cn.
authors.forename: Zhi-Dao
authors.initials: ZD
authors.lastname: Huang
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xyh0709@ustc.edu.cn.
authors.forename: Zheng-Li
authors.initials: ZL
authors.lastname: Liu
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xyh0709@ustc.edu.cn.
authors.forename: Tian-Xiang
authors.initials: TX
authors.lastname: Wang
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xyh0709@ustc.edu.cn.
authors.forename: Yun-He
authors.initials: YH
authors.lastname: Xu
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xyh0709@ustc.edu.cn and Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371. teckpeng@ntu.edu.sg.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh