title: A facile microwave synthetic route for ferrite nanoparticles with direct impact in magnetic particle hyperthermia.
abstract: The application of ferrite magnetic nanoparticles (MNPs) in medicine finds its rapidly developing emphasis on heating mediators for magnetic hyperthermia, the ever-promising "fourth leg" of cancer treatment. Usage of MNPs depends largely on the preparation processes to select optimal conditions and effective routes to finely tailor MNPs. Microwave heating, instead of conventional heating offers nanocrystals at significantly enhanced rate and yield. In this work, a facile mass-production microwave hydrothermal synthetic approach was used to synthesize stable ferromagnetic manganese and cobalt ferrite nanoparticles with sizes smaller than 14 nm from metal acetylacetonates in the presence of octadecylamine. Prolonging the reaction time from 15 to 60 min, led to ferrites with improved crystallinity while the sizes are slight increased. The high crystallinity magnetic nanoparticles showed exceptional magnetic heating parameters. In vitro application was performed using the human osteosarcoma cell line Saos-2 incubated with manganese ferrite nanoparticles. Hyperthermia applied in a two cycle process, while AC magnetic field remained on until the upper limit of 45 °C was achieved. The comparative results of the AC hyperthermia efficiency of ferrite nanoparticles in combination with the in vitro study coincide with the magnetic features and their tunability may be further exploited for AC magnetic hyperthermia driven applications.
authors.affiliation: Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Makridis
authors.affiliation: Department of Inorganic Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Chatzitheodorou
authors.affiliation: Laboratory of Clinical and Molecular Endocrinology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Topouridou
authors.affiliation: Laboratory of Clinical and Molecular Endocrinology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: M P
authors.initials: MP
authors.lastname: Yavropoulou
authors.affiliation: Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Angelakeris
authors.affiliation: Department of Inorganic Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. Electronic address: samkat@chem.auth.gr.
authors.forename: C
authors.initials: C
authors.lastname: Dendrinou-Samara
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D017895:Manganese Compounds / Q000737:chemistry; D008872:Microwaves; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D017895:Manganese Compounds; C569492:cobalt ferrite; C551151:manganese ferrite; C001215:ferrite; D003035:Cobalt
keywords: Ferrite nanoparticles; In vitro magnetic hyperthermia; Microwave hydrothermal synthesis