title: Characterization of ibuprofen microparticle and improvement of the dissolution.
abstract: The objective of this study was to prepare ibuprofen (IBP) microparticles by pH-change method and enhance the dissolution rate in vitro. Tween80 and Cremophor RH40 were selected as stabilizers to change the microparticles morphology. The microparticles were evaluated by dissolution profiles and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), laser particle size analyzer, scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). IBP microparticle prepared with surfactants showed a significant increase in dissolution rate (more than three times within 10 min) and an obvious decrease in mean particle size. The morphology of microparticles was obviously changed. XRD and DSC results revealed that the crystalline state of the untreated IBP and the prepared IBP microparticles were similar. The crystallinity of microparticles produced might be lightly reduced by adding surfactants in preparation process. All results showed that it was useful to prepare high dispersion microparticle by adding surfactants in the preparation process for improving the dissolution.
authors.affiliation: a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.
authors.forename: Fuzheng
authors.initials: F
authors.lastname: Ren
authors.affiliation: a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Su
authors.affiliation: a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xiong
authors.affiliation: a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.affiliation: a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.
authors.forename: Guobin
authors.initials: G
authors.lastname: Ren
authors.affiliation: a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.
authors.forename: Qiufang
authors.initials: Q
authors.lastname: Jing
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D005079:Excipients / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D011136:Polysorbates; D013501:Surface-Active Agents; C022131:cremophor; D011092:Polyethylene Glycols; D007052:Ibuprofen
keywords: Cremophor RH40; Tween 80; dissolution; ibuprofen; microparticle