title: Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model.
abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorder. It is characterized by the formation of amyloid plaques and neurofibrillary tangles in the brain, the degeneration of cholinergic neurons and neuronal cell death. The present study aimed to investigate the effect of luteolin, a flavonoid compound, on memory impairment in a streptozotocin (STZ)‑induced Alzheimer's rat model. Morris water maze and probe tests were performed to examine the effect of luteolin treatment on cognition and memory. The effect of luteolin on CA1 pyramidal layer thickness was also examined. The results demonstrated that luteolin significantly ameliorated the spatial learning and memory impairment induced by STZ treatment. STZ significantly reduced the thickness of CA1 pyramidal layer and treatment of luteolin completely abolished the inhibitory effect of STZ. Our results suggest that luteolin has a potentially protective effect on learning defects and hippocampal structures in AD.
authors.affiliation: Department of Neurology, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Xinxiang Hospital of Municipal Offices, Xinxiang, Henan 453000, P.R. China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pathology, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Huixin
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Zhenyong
authors.initials: Z
authors.lastname: Che
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D047311:Luteolin / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000633:toxicity
chemical_list: D013311:Streptozocin; D047311:Luteolin