title: Independent Prognostic Factors for Acute Organophosphorus Pesticide Poisoning.
abstract: BACKGROUND
  Acute organophosphorus pesticide poisoning (AOPP) is becoming a significant problem and a potential cause of human mortality because of the abuse of organophosphate compounds. This study aims to determine the independent prognostic factors of AOPP by using multivariate logistic regression analysis.
  
  
  METHODS
  The clinical data for 71 subjects with AOPP admitted to our hospital were retrospectively analyzed. This information included the Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, 6-h post-admission blood lactate levels, post-admission 6-h lactate clearance rates, admission blood cholinesterase levels, 6-h post-admission blood cholinesterase levels, cholinesterase activity, blood pH, and other factors. Univariate analysis and multivariate logistic regression analyses were conducted to identify all prognostic factors and independent prognostic factors, respectively. A receiver operating characteristic curve was plotted to analyze the testing power of independent prognostic factors.
  
  
  RESULTS
  Twelve of 71 subjects died. Admission blood lactate levels, 6-h post-admission blood lactate levels, post-admission 6-h lactate clearance rates, blood pH, and APACHE II scores were identified as prognostic factors for AOPP according to the univariate analysis, whereas only 6-h post-admission blood lactate levels, post-admission 6-h lactate clearance rates, and blood pH were independent prognostic factors identified by multivariate logistic regression analysis. The receiver operating characteristic analysis suggested that post-admission 6-h lactate clearance rates were of moderate diagnostic value.
  
  
  CONCLUSIONS
  High 6-h post-admission blood lactate levels, low blood pH, and low post-admission 6-h lactate clearance rates were independent prognostic factors identified by multivariate logistic regression analysis.
authors.affiliation: Intensive Care Unit, First People's Hospital of Fuyang, Hangzhou, Zhejiang, China. tangweidongmed@yeah.net.
authors.forename: Weidong
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Emergency Medicine, the Second Affiliated Hospital of Medical College in Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ruan
authors.affiliation: Intensive Care Unit, First People's Hospital of Fuyang, Hangzhou, Zhejiang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Intensive Care Unit, First People's Hospital of Fuyang, Hangzhou, Zhejiang, China.
authors.forename: Suping
authors.initials: S
authors.lastname: Chen
authors.affiliation: Intensive Care Unit, First People's Hospital of Fuyang, Hangzhou, Zhejiang, China.
authors.forename: Xuebo
authors.initials: X
authors.lastname: Shao
authors.affiliation: Intensive Care Unit, First People's Hospital of Fuyang, Hangzhou, Zhejiang, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Emergency Medicine, the Second Affiliated Hospital of Medical College in Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Zhang
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D062025:Organophosphate Poisoning / Q000097:blood* / Q000401:mortality; D010575:Pesticides / Q000506:poisoning*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D010575:Pesticides; D019344:Lactic Acid; D002802:Cholinesterases
keywords: acute organophosphorus pesticide poisoning (AOPP); independent prognostic factors; multivariate logistic regression analysis; receiver operating characteristic curve