title: Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection.
abstract: Vitamin B-6 has a strong antioxidative effect. It would be useful to determine whether vitamin B-6 supplementation had effects on antioxidant capacities in patients with hepatocellular carcinoma (HCC) who had recently undergone tumor resection. Thirty-three HCC patients were randomly assigned to either the placebo (n = 16) group or the vitamin B-6 50 mg/d (n = 17) group for 12 weeks. Plasma pyridoxal 5'-phosphate, homocysteine, indicators of oxidative stress, and antioxidant capacities were measured. Plasma homocysteine in the vitamin B-6 group was significantly decreased at week 12, while the level of trolox equivalent antioxidant capacity (TEAC) was significantly increased at the end of the intervention period. Vitamin B-6 supplementation had a significant reducing effect on the change of plasma homocysteine (β = -2.4, p = 0.02) but not on the change of TEAC level after adjusting for potential confounders. The change of plasma homocysteine was significantly associated with the change of TEAC after adjusting for potential confounders (β = -162.0, p = 0.03). Vitamin B-6 supplementation seemed to mediate antioxidant capacity via reducing plasma homocysteine rather than having a direct antioxidative effect in HCC patients who had recently undergone tumor resection. The clinical trial number is NCT01964001, ClinicalTrials.gov.
authors.affiliation: Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
authors.forename: Shao-Bin
authors.initials: SB
authors.lastname: Cheng
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Lin
authors.affiliation: Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
authors.forename: Hsiao-Tien
authors.initials: HT
authors.lastname: Liu
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan.
authors.forename: Yi-Shan
authors.initials: YS
authors.lastname: Peng
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
authors.forename: Shih-Chien
authors.initials: SC
authors.lastname: Huang
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
authors.forename: Yi-Chia
authors.identifier: 0000-0003-2234-4464
authors.initials: YC
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D006710:Homocysteine; D025101:Vitamin B 6