title: Different risk factors for advanced colorectal neoplasm in young adults.
abstract: OBJECTIVE
  To compare the risk of developing advanced colorectal neoplasm (ACRN) according to age in Koreans.
  
  
  METHODS
  A total of 70428 Koreans from an occupational cohort who underwent a colonoscopy between 2003 and 2012 at Kangbuk Samsung Hospital were retrospectively selected. We evaluated and compared odds ratios (OR) for ACRN between the young-adults (YA < 50 years) and in the older-adults (OA ≥ 50 years). ACRN was defined as an adenoma ≥ 10 mm in diameter, adenoma with any component of villous histology, high-grade dysplasia, or invasive cancer.
  
  
  RESULTS
  In the YA group, age (OR = 1.08, 95%CI: 1.06-1.09), male sex (OR = 1.26, 95%CI: 1.02-1.55), current smoking (OR = 1.37, 95%CI: 1.15-1.63), family history of colorectal cancer (OR = 1.46, 95%CI: 1.01-2.10), diabetes mellitus related factors (OR = 1.27, 95%CI: 1.06-1.54), obesity (OR = 1.23, 95%CI: 1.03-1.47), CEA (OR = 1.04, 95%CI: 1.01-1.09) and low-density lipoprotein-cholesterol (OR = 1.01, 95%CI: 1.01-1.02) were related with an increased risk of ACRN. However, age (OR = 1.08, 95%CI: 1.06-1.09), male sex (OR = 2.12, 95%CI: 1.68-2.68), current smoking (OR = 1.38, 95%CI: 1.12-1.71), obesity (OR = 1.34, 95%CI: 1.09-1.65) and CEA (OR = 1.05, 95%CI: 1.01-1.09) also increased the risk of ACRN in the OA group.
  
  
  CONCLUSIONS
  The risks of ACRN differed based on age group. Different colonoscopic screening strategies are appropriate for particular subjects with risk factors for ACRN, even in subjects younger than 50 years.
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Yoon Suk
authors.initials: YS
authors.lastname: Jung
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Hong Joo
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Yong Kyun
authors.initials: YK
authors.lastname: Cho
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Chong Il
authors.initials: CI
authors.lastname: Sohn
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Woo Kyu
authors.initials: WK
authors.lastname: Jeon
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Byung Ik
authors.initials: BI
authors.lastname: Kim
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Kyu Yong
authors.initials: KY
authors.lastname: Choi
authors.affiliation: Ji Yeon Kim, Comprehensive Health Care Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 10812, South Korea.
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Park
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D000367:Age Factors; D002277:Carcinoma / Q000175:diagnosis / Q000209:etiology*; D016009:Chi-Square Distribution; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors
keywords: Advanced colorectal neoplasm; Age; Metabolic abnormality; Risk factors; Young-adult