title: [Infection Control Effect of Dietary Fluid with Whey Peptide in the Management of Patients with Severe Intracranial Hemorrhage During the Acute Stage].
abstract: Abstract
  
  
  OBJECTIVE
  Patients with severe intracranial hemorrhage (ICH) often develop infectious complications during the acute stage. Animal experiments have demonstrated that enteral immunonutrition with a dietary fluid containing whey peptide (WP) enhances immunoactivity and prevents infection. The aim of the current study was to investigate the infection control effect of WP in the clinical management of patients with severe ICH.
  
  
  METHODS
  Fourteen patients with ICH were given enteral nutrition from January 2012 to December 2012. Nine patients were given WP (WP group) and the other five were given control dietary fluid (Non-WP group) for two weeks. We retrospectively analyzed the incidence of infectious complications and chronological changes in white blood cell (WBC) count, C-reactive protein (CRP), and total lymphocyte count.
  
  
  RESULTS
  All patients in the Non-WP Group experienced infectious complications, whereas 5 out of 9 patients in the WP Group did not experience them. There was a tendency for a decrease in WBC count and CRP value in the WP group. In contrast, WBC and CRP increased in 3 patients in the Non-WP Group. Total lymphocyte count tended to increase earlier in the WP Group; however this tendency was not noted in the Non-WP Group.
  
  
  CONCLUSIONS
  Although the number of cases was small, our study suggests that WP might have an infection control effect, capable of preventing infectious complications associated with severe ICH in the acute stage.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Shimogawa
authors.forename: Takato
authors.initials: T
authors.lastname: Morioka
authors.forename: Noriko
authors.initials: N
authors.lastname: Hagiwara
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sayama
authors.forename: Sei
authors.initials: S
authors.lastname: Haga
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Furuta
authors.forename: Kei
authors.initials: K
authors.lastname: Murao
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kanazawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Arakawa
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004032:Diet; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000178:diet therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications / Q000517:prevention & control*; D000067796:Whey / Q000008:administration & dosage*