title: Italian consensus conference for the outpatient autologous stem cell transplantation management in multiple myeloma.
abstract: Multiple myeloma (MM) is the leading indication for autologous stem cell transplantation (ASCT) worldwide. The safety and efficacy of reducing hospital stay for MM patients undergoing ASCT have been widely explored, and different outpatient models have been proposed. However, there is no agreement on the criteria for selecting patients eligible for this strategy as well as the standards for their clinical management. On the basis of this rationale, the Italian Group for Stem Cell Transplantation (GITMO) endorsed a project to develop guidelines for the management of outpatient ASCT in MM, using evidence-based knowledge and consensus-formation techniques. An expert panel convened to discuss the currently available data on the practice of outpatient ASCT management and formulated recommendations according to the supporting evidence. Evidence gaps were filled with consensus-based statements. Three main topics were addressed: (1) the identification of criteria for selecting MM patients eligible for outpatient ASCT management; (2) the definition of standard procedures for performing outpatient ASCT (model, supportive care and monitoring during the aplastic phase); (3) the definition of the standard criteria and procedures for re-hospitalization during the aplastic phase at home. Herein, we report the summary and the results of the discussion and the consensus.
authors.affiliation: Dipartimento di Onco-Ematologia, Ematologia con Trapianto di Midollo Osseo, Azienda Ospedaliera BMM, Reggio Calabria, Italy.
authors.forename: M
authors.identifier: http://orcid.org/0000-0002-3987-419X
authors.initials: M
authors.lastname: Martino
authors.affiliation: Cattedra di Ematologia, Dipartimento di Medicina Interna e Specialità Mediche, Università di Genova, Genova, Italy.
authors.forename: R M
authors.initials: RM
authors.lastname: Lemoli
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, Policlinico Umberto I, "Università la Sapienza", Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Girmenia
authors.affiliation: Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano (MI), Italy.
authors.forename: L
authors.initials: L
authors.lastname: Castagna
authors.affiliation: Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Bruno
authors.affiliation: Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cavallo
authors.affiliation: Clinica di Ematologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Offidani
authors.affiliation: Clinica di Ematologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Scortechini
authors.affiliation: Clinica di Ematologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Montanari
authors.affiliation: Unità Trapianto di Midollo Osseo, Dipartimento di Ematologia, Azienda Ospedaliera Policlinico Vittorio Emanuele, Catania, Italy.
authors.forename: G
authors.identifier: http://orcid.org/0000-0002-7840-4414
authors.initials: G
authors.lastname: Milone
authors.affiliation: Clinica Medica Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Postacchini
authors.affiliation: Clinica di Ematologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Olivieri
mesh_terms: D002985:Clinical Protocols / Q000592:standards; D032921:Consensus; D003245:Consensus Statements as Topic; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006760:Hospitalization; D006801:Humans; D007558:Italy; D009101:Multiple Myeloma / Q000628:therapy*; D010045:Outpatients; D018579:Patient Selection; D017410:Practice Guidelines as Topic / Q000592:standards*; D014182:Transplantation, Autologous