title: Interferon gamma/NADPH oxidase defense system in immunity and cancer.
abstract: As a part of cellular pathogen defense, IFNγ triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells. Recent data show that a similar mechanism can also operate in IFNγ-mediated anticancer control. IFNγ is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence.
authors.affiliation: Department of Genome Integrity of Institute of Molecular Genetics of the ASCR, v.v.i. , Prague, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Hodny
authors.affiliation: Immunology Unit CCP, Institute of Molecular Genetics of the ASCR , v.v.i. , Prague, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Reinis
authors.affiliation: Department of Genome Integrity of Institute of Molecular Genetics of the ASCR, v.v.i. , Prague, Czech Republic.
authors.forename: Sona
authors.initials: S
authors.lastname: Hubackova
authors.affiliation: Laboratory of Cell Reproduction, Institute of Microbiology of the ASCR , v.v.i. , Prague, Czech Republic.
authors.forename: Pavla
authors.initials: P
authors.lastname: Vasicova
authors.affiliation: Department of Genome Integrity of Institute of Molecular Genetics of the ASCR, v.v.i., Prague, Czech Republic; Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: Jiri
authors.initials: J
authors.lastname: Bartek
keywords: Cellular senescence; DNA damage response; oxidative stress; tumor growth factor beta; tumor immunosurveillance