title: Exposure to ionizing radiation and brain cancer incidence: The Life Span Study cohort.
abstract: Ionizing radiation is a cause of cancer. This paper examines the effects of radiation dose and age at exposure on the incidence of brain cancer using data from the Life Span Study (LSS) of atomic bomb survivors.
  
  
  
  The Radiation Effects Research Foundation website provides demographic details of the LSS population, estimated radiation doses at time of bomb in 1945, person years of follow-up and incident cancers from 1958 to 1998. We modelled brain cancer incidence using background-stratified Poisson regression, and compared the excess relative risk (ERR) per Gray (Gy) of brain dose with estimates from follow-up studies of children exposed to diagnostic CT scans.
  
  
  
  After exposure to atomic bomb radiation at 10 years of age the estimated ERR/Gy was 0.91 (90%CI 0.53, 1.40) compared with 0.07 (90%CI -0.27, 0.56) following exposure at age 40. Exposure at 10 years of age led to an estimated excess of 17 brain tumors per 100,000 person year (pyr) Gy by 60 years of age. These LSS estimates are substantially less than estimates based on follow-up of children exposed to CT scans.
  
  
  
  Estimates of ERR/Gy for brain cancers in the LSS and haemangioma cohorts seem much smaller than estimates of risk for young persons in the early years after exposure to CT-scans. This could be due to reverse causation bias in the CT cohorts, diagnostic error, measurement error with radiation doses, loss of early follow-up in the LSS, or non-linearity of the dose-response curve.
authors.affiliation: School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, The University of Melbourne, Victoria 3010, Australia.
authors.forename: Nicolas R
authors.initials: NR
authors.lastname: Smoll
authors.affiliation: School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, The University of Melbourne, Victoria 3010, Australia; Department of Radiology, The Alfred, 55 Commercial Rd, Prahran, Victoria 3181, Australia.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Brady
authors.affiliation: School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, The University of Melbourne, Victoria 3010, Australia.
authors.forename: Katrina
authors.initials: K
authors.lastname: Scurrah
authors.affiliation: School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, The University of Melbourne, Victoria 3010, Australia. Electronic address: mathewsj@unimelb.edu.au.
authors.forename: John D
authors.initials: JD
authors.lastname: Mathews
mesh_terms: D001932:Brain Neoplasms; D015331:Cohort Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D054043:Nuclear Weapons; D011839:Radiation, Ionizing; D017741:Survivors
keywords: Brain tumors; CT scan; Ionizing radiation; Lifespan study; Radiation-induced cancer