title: An approach to (±)-Lingzhiol.
abstract: (±)-Lingzhiol has been synthesized from commercially available 5,8-dimethoxytetralone in seven steps with an overall yield of 10.3% via an unprecedented acid-catalyzed semipinacol-type rearrangement. In addition, a novel strategy for the construction of the tetracyclic 5/5/6/6 core structure of lingzhiol has been developed via a tandem rearrangement/reduction/lactonization reaction.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , No. 1 Xiannongtan Street, Beijing 100050, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , No. 1 Xiannongtan Street, Beijing 100050, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , No. 1 Xiannongtan Street, Beijing 100050, China.
authors.forename: Xiaozhen
authors.initials: X
authors.lastname: Jiao
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , No. 1 Xiannongtan Street, Beijing 100050, China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , No. 1 Xiannongtan Street, Beijing 100050, China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , No. 1 Xiannongtan Street, Beijing 100050, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
mesh_terms: D002384:Catalysis; D003500:Cyclization; D053138:Cyclohexenes / Q000737:chemistry; D015394:Molecular Structure; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry; D044024:Tetralones / Q000737:chemistry
chemical_list: C000610786:5,8-dimethoxytetralone; D053138:Cyclohexenes; D013729:Terpenes; D044024:Tetralones; C587942:lingzhiol; C519041:semipinacol