title: Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation.
abstract: Causative agents of infectious disease that are multidrug resistant bacterial pathogens represent a serious public health concern due to the increasingly difficult nature of achieving efficacious clinical treatments. Of the various acquired and intrinsic antimicrobial agent resistance determinants, integral-membrane multidrug efflux pumps of the major facilitator superfamily constitute a major mechanism of bacterial resistance. The major facilitator superfamily (MFS) encompasses thousands of known related secondary active and passive solute transporters, including multidrug efflux pumps, from bacteria to humans. This review article addresses recent developments involving the targeting by various modulators of bacterial multidrug efflux pumps from the major facilitator superfamily. It is currently of tremendous interest to modulate bacterial multidrug efflux pumps in order to eventually restore the clinical efficacy of therapeutic agents against recalcitrant bacterial infections. Such MFS multidrug efflux pumps are good targets for modulation.
authors.forename: Sanath
authors.initials: S
authors.lastname: Kumar
authors.forename: Guixin
authors.initials: G
authors.lastname: He
authors.forename: Prathusha
authors.initials: P
authors.lastname: Kakarla
authors.forename: Ugina
authors.initials: U
authors.lastname: Shrestha
authors.forename: K C
authors.initials: KC
authors.lastname: Ranjana
authors.forename: Indrika
authors.initials: I
authors.lastname: Ranaweera
authors.forename: T Mark
authors.initials: TM
authors.lastname: Willmon
authors.forename: Sharla R
authors.initials: SR
authors.lastname: Barr
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Hernandez
authors.affiliation: Eastern New Mexico University, Portales, NM 88130, USA. Manuel.Varela@enmu.edu.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Varela
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000235:genetics / Q000472:pathogenicity; D019450:Genes, MDR; D006801:Humans; D049990:Membrane Transport Modulators / Q000494:pharmacology*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins