title: Age and gender differences in the influences of eNOS T-786C polymorphism on arteriosclerotic parameters in general population in Japan.
abstract: OBJECTIVE
  The influence of T-786C polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) on arteriosclerotic parameters by age and gender were examined.
  
  
  METHODS
  Brachial-ankle pulse wave velocity (baPWV), heart-rate adjusted augmentation index (AIx@75), pulse pressure (PP) and albumin-creatinine ratio (ACR) were assessed as arteriosclerotic parameters in addition to non-high-density lipoprotein cholesterol (non-HDL-C) to HDL-C (non-HDL-C/HDL-C) ratio in 1499 participants. T-786C polymorphism (rs2070744) was screened using a TaqMan allelic discrimination assay. Analyses of covariance were carried.
  
  
  RESULTS
  Women with the non-C allele showed significantly lower AIx@75 in participants aged <65 years and baPWV in participants aged ≥65 years than those with C allele. In contrast, men with the non-C allele showed significantly higher PP in participants aged <65 years, and higher ACR and non-HDL-C/HDL-C ratio in participants aged ≥65 years. In men on cholesterol-lowering medication, the non-C allele carriers showed significantly higher non-HDL-C compared to those in the C allele carriers.
  
  
  CONCLUSIONS
  eNOS T-786C polymorphism is significantly associated with arteriosclerotic parameters accompanied with age and gender differences, possibly involving antioxidative and/or endothelial signaling other than inflammatory signaling.
authors.affiliation: Department of Public Health, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama City, Wakayama, 641-8509, Japan.
authors.forename: Marowa
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Wakayama Medical University School of Health and Nursing Science, 580 Mikazura, Wakayama City, Wakayama, 641-0011, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyai
authors.affiliation: Wakayama Medical University School of Health and Nursing Science, 580 Mikazura, Wakayama City, Wakayama, 641-0011, Japan.
authors.forename: Sonomi
authors.initials: S
authors.lastname: Hattori
authors.affiliation: Wakayama Medical University School of Health and Nursing Science, 580 Mikazura, Wakayama City, Wakayama, 641-0011, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Iwahara
authors.affiliation: Wakayama Medical University School of Health and Nursing Science, 580 Mikazura, Wakayama City, Wakayama, 641-0011, Japan.
authors.forename: Miyoko
authors.initials: M
authors.lastname: Utsumi
authors.affiliation: Wakayama Medical University School of Health and Nursing Science, 580 Mikazura, Wakayama City, Wakayama, 641-0011, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Arita
authors.affiliation: Department of Public Health, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama City, Wakayama, 641-8509, Japan. ttakeshi@wakayama-med.ac.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takeshita
mesh_terms: D000367:Age Factors; D001161:Arteriosclerosis / Q000453:epidemiology* / Q000235:genetics; D003430:Cross-Sectional Studies; D007564:Japan / Q000453:epidemiology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012737:Sex Factors
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: Arteriosclerotic parameters; T-786C; eNOS