title: Animal models of post-traumatic epilepsy.
abstract: Post-traumatic epilepsy (PTE) is defined as the development of unprovoked seizures in a delayed fashion after traumatic brain injury (TBI). PTE lies at the intersection of two distinct fields of study, epilepsy and neurotrauma. TBI is associated with a myriad of both focal and diffuse anatomic injuries, and an ideal animal model of epilepsy after TBI must mimic the characteristics of human PTE. The three most commonly used models of TBI are lateral fluid percussion, controlled cortical injury, and weight drop. Much of what is known about PTE has resulted from use of these models. In this review, we describe the most commonly used animal models of TBI with special attention to their advantages and disadvantages with respect to their use as a model of PTE.
authors.affiliation: The Neurological Institute, University Hospital Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ostergard
authors.affiliation: The Neurological Institute, University Hospital Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sweet
authors.affiliation: The Neurological Institute, University Hospital Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
authors.forename: Dorian
authors.initials: D
authors.lastname: Kusyk
authors.affiliation: The Neurological Institute, University Hospital Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
authors.forename: Eric
authors.initials: E
authors.lastname: Herring
authors.affiliation: The Neurological Institute, University Hospital Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States. Electronic address: Jonathan.Miller@UHHospitals.org.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Miller
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004834:Epilepsy, Post-Traumatic / Q000503:physiopathology; D006801:Humans
keywords: Animal models; Epilepsy; Traumatic brain injury