title: Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications.
abstract: Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment, which benefits the localization, attachment, proliferation, and differentiation of ASCs. Therefore, tissue-engineered ASCs are recognized as an attractive substitute for tissue and organ transplantation. In this paper, we review the characteristics of ASCs, as well as the biomaterials and tissue engineering methods used to proliferate and differentiate ASCs in a 3D environment. Clinical applications of tissue-engineered ASCs are also discussed to reveal the potential and feasibility of using tissue-engineered ASCs in regenerative medicine.
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7; West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Dai
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7.
authors.forename: Zongjie
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7.
authors.forename: Roya
authors.initials: R
authors.lastname: Samanipour
authors.affiliation: Department of Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors.forename: Kyo-In
authors.initials: KI
authors.lastname: Koo
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7.
authors.forename: Keekyoung
authors.initials: K
authors.lastname: Kim