title: Transgenesis for pig models.
abstract: Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expression like mice has been raised. Currently, advanced genome-editing technologies enable us to generate specific gene-deleted and -inserted pig models. In the future, the development of pig models with gene editing technologies could be a valuable resource for biomedical research.
authors.affiliation: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul 08826, Korea.
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Yum
authors.affiliation: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul 08826, Korea.|Department of Biotechnology & Laboratory Animals, Shingu College, Seongnam 13174, Korea.
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Yoon
authors.affiliation: Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
authors.forename: Choong-Il
authors.initials: CI
authors.lastname: Lee
authors.affiliation: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul 08826, Korea.
authors.forename: Byeong-Chun
authors.initials: BC
authors.lastname: Lee
authors.affiliation: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul 08826, Korea.|Emergence Center for Food-Medicine Personalized Therapy System, Advanced Institutes of Convergence Technology, Seoul National University, Suwon 16229, Korea.|Farm Animal Clinical Training and Research Center, Institutes of GreenBio Science Technology, Seoul National University, Pyeongchang 25354, Korea.
authors.forename: Goo
authors.initials: G
authors.lastname: Jang
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D018014:Gene Transfer Techniques / Q000662:veterinary*; D023421:Models, Animal; D034421:Sus scrofa / Q000235:genetics*
keywords: conditional expression; genome editing; knockout; pig; transgenesis