title: Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy.
abstract: OBJECTIVE
  Systematic review to determine any association between imaging features of idiopathic mesenteric panniculitis (MP) and subsequent malignancy.
  
  
  METHODS
  Two researchers searched primary literature independently for imaging studies of MP. They extracted data focusing on methodology for unbiased patient accrual and capability to determine a link between MP and subsequent malignancy. They noted imaging features of MP. Data were accrued and meta-analysis intended.
  
  
  RESULTS
  Fourteen of 675 articles were eligible; 1,226 patients. Only three (21 %) accrued patients prospectively. Twelve (86 %) studies described CT features. Follow-up varied widely; 1 month to 8 years. Prevalence of MP was influenced by accrual: 0.2 % for keyword search versus 1.7 % for consecutive series. Accrual bias affected nine (64 %) studies. 458 (38 %) of 1,209 patients had malignancy at accrual but varied widely (8-89 %), preventing meta-analysis. Sixty (6.4 %) of 933 patients developed new malignancy subsequently, also varying widely (0-11 %). Of just four studies that determined the proportion of unselected, consecutive patients with MP developing subsequent malignancy, three were retrospective and the fourth excluded patients with lymphadenopathy, likely excluding patients with MP.
  
  
  CONCLUSIONS
  Studies were heterogeneous, with biased accrual. No available study can determine an association between MP and subsequent malignancy with certainty.
  
  
  CONCLUSIONS
  • Our systematic review of mesenteric panniculitis found that imaging studies were biased. • Spectrum and recruitment bias was largely due to retrospective study designs. • No study could confirm a certain link between mesenteric panniculitis and subsequent malignancy. • Excessive methodological heterogeneity precluded meaningful meta-analysis. • High-quality research linking mesenteric panniculitis imaging features and subsequent malignancy is needed.
authors.affiliation: Centre for Medical Imaging, University College London UCL, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK. s.halligan@ucl.ac.uk.
authors.forename: Steve
authors.initials: S
authors.lastname: Halligan
authors.affiliation: Centre for Medical Imaging, University College London UCL, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Plumb
authors.affiliation: Centre for Medical Imaging, University College London UCL, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK.
authors.forename: Stuart
authors.initials: S
authors.lastname: Taylor
mesh_terms: D015982:Bias; D006801:Humans; D015436:Panniculitis, Peritoneal / Q000000981:diagnostic imaging* / Q000453:epidemiology; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012306:Risk; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Computed tomography, spiral; Helical computed tomography; Panniculitis; Panniculitis, peritoneal; Sclerosing mesenteritis