title: Chronic hepatitis B and C infection in the United States: a review of current guidelines, disease burden and cost effectiveness of screening.
abstract: Chronic hepatitis B and C infection are the leading causes of hepatocellular carcinoma and liver related death in the world and in the United States respectively. Screening guidelines have been developed based on estimated prevalence determined by NHANES data. However, individuals with the most risk of chronic infection (incarcerated, homeless, immigrants, nursing home residents, and hospitalized persons) are underrepresented in this cohort leading to an underestimation of the true prevalence of chronic hepatitis B and C infection. This has led to recent updates in the screening guidelines. This review examines the change in the guidelines, the likely true seroprevalence of hepatitis B and C virus, as well as the burden of chronic infection in this population.
authors.affiliation: a Division of Liver Diseases, Icahn School of Medicine at Mount Sinai , NY , New York , USA.
authors.forename: Dost
authors.initials: D
authors.lastname: Sarpel
authors.affiliation: a Division of Liver Diseases, Icahn School of Medicine at Mount Sinai , NY , New York , USA.
authors.forename: Esha
authors.initials: E
authors.lastname: Baichoo
authors.affiliation: a Division of Liver Diseases, Icahn School of Medicine at Mount Sinai , NY , New York , USA.
authors.forename: Douglas T
authors.initials: DT
authors.lastname: Dieterich
mesh_terms: D003362:Cost-Benefit Analysis; D017408:Guidelines as Topic; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000191:economics* / Q000453:epidemiology*; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000191:economics* / Q000453:epidemiology*; D006801:Humans; D011159:Population Surveillance; D014481:United States / Q000453:epidemiology
keywords: Chronic hepatitis B; chronic hepatitis C; guidelines; prevalence; screening