title: Forty five years with membrane phospholipids, phospholipases and lipid mediators: A historical perspective.
abstract: Phospholipases play a key role in the metabolism of phospholipids and in cell signaling. They are also a very useful tool to explore phospholipid structure and metabolism as well as membrane organization. They are at the center of this review, covering a period starting in 1971 and focused on a number of subjects in which my colleagues and I have been involved. Those include determination of phospholipid asymmetry in the blood platelet membrane, biosynthesis of lysophosphatidic acid, biochemistry of platelet-activating factor, first attempts to define the role of phosphoinositides in cell signaling, and identification of novel digestive (phospho)lipases such as pancreatic lipase-related protein 2 (PLRP2) or phospholipase B. Besides recalling some of our contributions to those various fields, this review makes an appraisal of the impressive and often unexpected evolution of those various aspects of membrane phospholipids and lipid mediators. It is also the occasion to propose some new working hypotheses.
authors.affiliation: Centre de Physiopathologie de Toulouse Purpan, Institut National de la Santé et de la Recherche Médicale, U1043, Toulouse F-31300, France; Centre National de la Recherche Scientifique, U5282, Toulouse F-31300, France; Université de Toulouse, Université Paul Sabatier, Toulouse F-31300, France. Electronic address: hugues.chap.@univ-tlse3.fr.
authors.forename: Hugues
authors.initials: H
authors.lastname: Chap
mesh_terms: D035843:Biomedical Research / Q000266:history*; D001792:Blood Platelets / Q000378:metabolism*; D049673:History, 20th Century; D049674:History, 21st Century; D008049:Lipase / Q000266:history / Q000378:metabolism; D008245:Lysophospholipase / Q000266:history / Q000378:metabolism; D010743:Phospholipids / Q000266:history / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D010743:Phospholipids; D008049:Lipase; C075988:pancreatic lipase related protein 2; D008245:Lysophospholipase
keywords: Lysophosphatidic; PLRP2; Phosphoinositides; Phospholipase B; Phospholipid asymmetry; Platelet-activating factor