title: Effectiveness and safety of oxycodone/naloxone in the management of chronic pain in patients with systemic sclerosis with recurrent digital ulcers: two case reports.
abstract: Digital ulcers (DUs) are a severe and frequent clinical feature of patients with systemic sclerosis (SSc). The presence of DUs may cause severe pain and often lead to impairment of patient's functional activities and health-related quality of life. Moreover, poor patient cooperation during the wound care procedure due to pain may be associated with a negative outcome of DU healing. Therefore, pain management has a key role in patients with SSc. These two case reports describe the effectiveness and safety of oxycodone/naloxone in patients with SSc complicated by painful chronic DUs. Such a therapy has provided pain relief and consequently an increased compliance during redressing wounds.
authors.affiliation: Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Institute, The University of Milan, Milan, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Ughi
authors.affiliation: Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Institute, The University of Milan, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Crotti
authors.affiliation: Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Institute, The University of Milan, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Ingegnoli
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D059350:Chronic Pain / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005385:Fingers; D006801:Humans; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage* / Q000009:adverse effects; D010098:Oxycodone / Q000008:administration & dosage* / Q000009:adverse effects; D059408:Pain Management; D011788:Quality of Life; D012595:Scleroderma, Systemic / Q000150:complications*; D012883:Skin Ulcer / Q000503:physiopathology* / Q000628:therapy; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D009270:Naloxone; D010098:Oxycodone
keywords: UCLA-SCTC GIT 2.0; analgaesia; calcinosis; digital ulcer; naloxone; opioids; oxycodone; pain; scleroderma; systemic sclerosis; wound healing