title: Combined microwave ablation and systemic chemotherapy for liver metastases from oesophageal cancer: Preliminary results and literature review.
abstract: Oesophageal cancer is a highly aggressive disease with about 50% of patients presenting with advanced or metastatic disease at initial diagnosis. In this study we assessed combined microwave ablation (MWA) and systemic chemotherapy in the treatment of liver metastases arising from oesophageal squamous cell carcinoma (OSCC).
  
  
  
  Between February 2009 and June 2014, OSCC patients who underwent percutaneous MWA + concurrent systemic chemotherapy and systemic chemotherapy alone for liver metastases were enrolled in this study. Overall survival (OS) and progression-free survival (PFS) were recorded and compared between groups.
  
  
  
  In total 15 patients with 25 liver metastases who underwent ultrasound-guided percutaneous MWA and chemotherapy were enrolled in this study. Technical success was achieved in 96% (24/25) of metastatic liver tumours. No major or minor complications associated with MWA procedures were observed. The median OS and PFS from initial MWA were 13 months and 4 months. The 1-, 2-, 3-, 4-year OS rates after MWA were 53.3%, 26.7%, 13.3%, and 13.3%, respectively. The 1- and 2-year PFS rates after MWA were 26.7% and 13.3%. The OS and PFS of the MWA + systemic chemotherapy group were superior than those of patients who received systemic chemotherapy alone (P = 0.011 and 0.030, respectively).
  
  
  
  Combined MWA with systemic chemotherapy is a feasible, safe and effective treatment for liver metastases from OSCC.
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Fubo
authors.initials: F
authors.lastname: Zhou
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Yu
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Han
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Fangyi
authors.initials: F
authors.lastname: Liu
authors.affiliation: a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China ;
authors.forename: Shuilian
authors.initials: S
authors.lastname: Tan
authors.affiliation: b Department of Oncology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Guanghai
authors.initials: G
authors.lastname: Dai
authors.affiliation: b Department of Oncology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Li
authors.initials: L
authors.lastname: Bai
mesh_terms: D055011:Ablation Techniques; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008297:Male; D008872:Microwaves; D008875:Middle Aged; D016019:Survival Analysis; D043823:Taxoids / Q000627:therapeutic use; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil
keywords: Liver metastases; microwave ablation; oesophageal cancer; systemic chemotherapy