title: Advances in Nanotechnology for the Treatment of Osteoporosis.
abstract: Osteoporosis is a degenerative bone disease commonly related to aging. With an increase in life expectancies worldwide, the prevalence of the disease is expected to rise. Current clinical therapeutic treatments are not able to offer long-term solutions to counter the bone mass loss and the increased risk of fractures, which are the primary characteristics of the disease. However, the combination of bioactive nanomaterials within a biomaterial scaffold shows promise for the development of a localized, long-term treatment for those affected by osteoporosis. This review summarizes the unique characteristics of engineered nanoparticles that render them applicable for bone regeneration and recaps the current body of knowledge on nanomaterials with potential for osteoporosis treatment and bone regeneration. Specifically, we highlight new developments that are shaping this emerging field and evaluate applications of recently developed nanomaterials for osteoporosis treatment. Finally, we will identify promising new research directions in nanotechnology for bone regeneration.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77841, USA.
authors.forename: Mikayla
authors.initials: M
authors.lastname: Barry
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77841, USA.
authors.forename: Hannah
authors.initials: H
authors.lastname: Pearce
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77841, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Cross
authors.affiliation: Maxillofacial Unit, Calabrodental Clinic, Crotone, 88900, Italy.|Regenerative Medicine Section, Tecnologica Research Institute, Crotone, 88900, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Tatullo
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77841, USA. gaharwar@tamu.edu.|Department of Materials Science and Engineering, Texas A&M University, College Station, TX, 77841, USA. gaharwar@tamu.edu.|Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX, 77843, USA. gaharwar@tamu.edu.
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Gaharwar
mesh_terms: D001672:Biocompatible Materials; D015519:Bone Density; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage*; D001861:Bone Regeneration; D016723:Bone Remodeling; D016503:Drug Delivery Systems; D004967:Estrogens / Q000008:administration & dosage*; D050723:Fractures, Bone / Q000517:prevention & control*; D006801:Humans; D049329:Nanostructures / Q000627:therapeutic use*; D036103:Nanotechnology; D010024:Osteoporosis / Q000628:therapy*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D004967:Estrogens
keywords: Bioactive nanomaterials; Bone regeneration; Nanotechnology; Osteoporosis