title: [Stereotactic brain biopsy guided by iMRI co-registration combined with PET/CT].
abstract: OBJECTIVE
  To explore the clinical value of intraoperative magnetic resonance imaging (iMRI) coregistration combined with position emission tomography/computed tomography (PET/CT) in stereotactic brain biopsy.
  
  
  METHODS
  Forty nine patients with intracranial lesions were operated by stereotactic biopsy from June 2010 to June 2015 in Tianjin Medical University General Hospital. Seventeen patient's operation was guided by iMRI only (group A), thirty two patients' operation was guided by iMRI and PET/CT (group B). The diagnosis success rate and operation related complications were compared between the two groups.
  
  
  RESULTS
  PET/CT and iMRI were integrated successfully in all cases of group B. Fourteen patients (82.4%) of group A and all 32 patients (100%) of group B had final diagnosis confirmed by histopathological and immunohistochemical observation. The diagnosis success rate of group B was higher than group A (P<0.05). There were 5 patients in total who had postoperative complication, 2 (11.8%) in group A and 3 (9.3%) in group B, but the difference was not statistically significant.
  
  
  CONCLUSIONS
  PET/CT based metabolic imaging can be automatically integrated with standard MRI guided stereotactic biopsy. Compared with iMRI only, the combined treatment improves diagnosis success rate without increasing complications; it's safe, and has high clinical efficacy.
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: J W
authors.initials: JW
authors.lastname: Zhao
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Z G
authors.initials: ZG
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
authors.forename: P
authors.initials: P
authors.lastname: He
authors.forename: Y
authors.initials: Y
authors.lastname: Jia
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: M Q
authors.initials: MQ
authors.lastname: Li
authors.forename: J N
authors.initials: JN
authors.lastname: Zhang
authors.forename: S Y
authors.initials: SY
authors.lastname: Yue
authors.forename: W D
authors.initials: WD
authors.lastname: Yang
mesh_terms: D001706:Biopsy / Q000379:methods*; D001921:Brain / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D011183:Postoperative Complications; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed