title: First report of Polycystic kidney disease occurrence in Persian cats in Serbia.
abstract: Polycystic kidney disease (PKD) is an inherited autosomal disorder in cats, mostly diagnosed in Persian cats. Renal cysts can be diagnosed by ultrasound, but cats must be at least 16 weeks old. The goals of this study were to assess the occurrence of PKD in Serbia using a randomly selected group of Persian cats, to compare the diagnostic efficacy of ultrasound and genetic tests, and to measure haematological and selected biochemical parameters. We examined 70 cats of Persian breed, between 4 months and 8 years of age. Complete blood count and selected biochemical parameters were measured, renal ultrasound was performed. Swabs of the oral cavity were obtained for genetic testing. Percentage of PKD positive cats identified by genetic testing was 48.6%, whilst only 18.6% were detected through ultrasound. Animals that were polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) positive and ultrasound negative ranged from 4 months to 3.5 years. All haematological and biochemical parameters were within the the normal range values in all examined cats. Genetic methods proved to be the most effective for reliable and early diagnosis of PKD in Persian cats. DNA analysis can be used right after birth, and excludes the need for other diagnostic procedures, such as ultrasound.
authors.affiliation: University of Belgrade, Faculty of Veterinary Medicine, Department of Equine, Small Animal, Poultry and Wild Animal Diseases, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia.
authors.forename: Milos
authors.initials: M
authors.lastname: Vucicevic
authors.forename: Dajana
authors.initials: D
authors.lastname: Slijepcevic
authors.forename: Darko
authors.initials: D
authors.lastname: Davitkov
authors.forename: Vladimir
authors.initials: V
authors.lastname: Avdalovic
authors.forename: Sanja
authors.initials: S
authors.lastname: Aleksic-Kovacevic
authors.forename: Jevrosima
authors.initials: J
authors.lastname: Stevanovic
authors.forename: Zoran
authors.initials: Z
authors.lastname: Stanimirovic
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis / Q000453:epidemiology*; D002415:Cats; D005260:Female; D008297:Male; D007690:Polycystic Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D055771:Serbia / Q000453:epidemiology