title: Asymmetric Synthesis of Axinellamines A and B.
abstract: Axinellamines A and B are broad-spectrum antibacterial pyrrole-imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and an anchimeric chlorination reaction.
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.|Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.|Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
authors.forename: Yuyong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA. Chuo.Chen@UTSouthwestern.edu.
authors.forename: Chuo
authors.identifier: http://orcid.org/0000-0002-3118-4901
authors.initials: C
authors.lastname: Chen
mesh_terms: D007093:Imidazoles / Q000138:chemical synthesis*; D007536:Isomerism; D011758:Pyrroles / Q000138:chemical synthesis*
chemical_list: D007093:Imidazoles; D011758:Pyrroles; C520388:axinellamine
keywords: alkaloids; anchimeric assistance; axinellamines; natural products; total synthesis