title: Obesity and kidney disease: Beyond the hyperfiltration.
abstract: In industrialized countries, overweight and obesity account for approximately 13.8% and 24.9% of the kidney disease observed in men and women, respectively. Moreover, obesity-associated glomerulopathy is now considered as "an emerging epidemic." Kidney function can be negatively impacted by obesity through several mechanisms, either direct or indirect. While it is well established that obesity represents the leading risk factor for type 2 diabetes and hypertension, awareness that obesity is associated with direct kidney damage independently of hypertension and diabetes is still not widespread. In this paper we will discuss the emerging role of adipose tissue, particularly in the visceral depot, in obesity-induced chronic kidney damage.
authors.affiliation: Division of Hypertension and Nephrology, Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mascali
authors.affiliation: Division of Hypertension and Nephrology, Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Franzese
authors.affiliation: Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy steven.nistico@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Nisticò
authors.affiliation: MedStar Cardiovascular Research Network, Washington, DC, USA.
authors.forename: U
authors.initials: U
authors.lastname: Campia
authors.affiliation: Endocrinology Unit, University of Rome Tor Vergata, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Lauro
authors.affiliation: Internal Medicine, Catholic University, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cardillo
authors.affiliation: Division of Hypertension and Nephrology, Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Di Daniele
authors.affiliation: Division of Hypertension and Nephrology, Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tesauro
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology*; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications; D012307:Risk Factors
keywords: hyperfiltration; kidney disease; obesity