title: 25-year follow-up after lung transplantation at Lund University Hospital in Sweden: superior results obtained for patients with cystic fibrosis.
abstract: In Sweden, two centres perform lung transplantation for a population of about 9 million and the entire population is covered for lung transplantation by government health insurance. Lund University Hospital is one of these centres. This retrospective report reviews the 25-year experience of the Skåne University Hospital Lung Transplant Program with particular emphasis on short-term outcome and long-term survival but also between different subgroups of patients and types of transplant [single-lung transplantation (SLTx) versus double-lung transplantation (DLTx)] procedure performed.
  
  
  
  Between January 1990 and June 2014, 278 patients underwent lung transplantation at the Skåne University Hospital Sweden. DLTx was performed in 172 patients, SLTx was performed in 97 patients and heart-lung transplantation was performed in 9 patients. In addition, 15 patients required retransplantation (7 DLTx and 8 SLTx).
  
  
  
  Overall 1-, 5-, 10-, 15- and 20-year survival rates were 88, 65, 49, 37 and 19% for the whole cohort. DLTx recipients showed 1-, 5-, 10- and 20-year survival rates of 90, 71, 60 and 30%, compared with SLTx recipients with 1-, 5-, 10- and 20-year survival rates of 83, 57, 34 and 6% (P < 0.05), respectively. Comparing the use of intraoperative extracorporeal membrane oxygenation, extracorporeal circulation (ECC) and no circulatory support in the aspect of survival, a significant difference in favour of intraoperative ECC was seen.
  
  
  
  Superior long-term survival rates were seen in recipients diagnosed with cystic fibrosis, α1-antitrypsin deficiency and pulmonary hypertension. DLTx showed better results compared with SLTx especially at 10 years post-transplant. In the present study, we present cumulative incidence rates of bronchiolitis obliterans syndrome of 15% at 5 years, 26% at 10 years and 32% at 20 years post-transplant; these figures are in line with the lowest rates presented internationally.
authors.affiliation: Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Fakhro
authors.affiliation: Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Richard
authors.initials: R
authors.lastname: Ingemansson
authors.affiliation: Department of Pulmonary Medicine, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Skog
authors.affiliation: Department of Thoracic Intensive Care and Anesthesia, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Algotsson
authors.affiliation: Department of Pulmonary Medicine, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Lennart
authors.initials: L
authors.lastname: Hansson
authors.affiliation: Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Bansi
authors.initials: B
authors.lastname: Koul
authors.affiliation: Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Ronny
authors.initials: R
authors.lastname: Gustafsson
authors.affiliation: Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Wierup
authors.affiliation: Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden sandra.lindstedt.ingemansson@gmail.com.
authors.forename: Sandra
authors.initials: S
authors.lastname: Lindstedt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001989:Bronchiolitis Obliterans / Q000453:epidemiology; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D006976:Hypertension, Pulmonary / Q000401:mortality / Q000601:surgery; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate; D013548:Sweden; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult; D019896:alpha 1-Antitrypsin Deficiency / Q000401:mortality / Q000601:surgery
keywords: Cystic fibrosis; Long-term follow-up; Lung; Survival; Transplantation