title: Plasma orexin-A level associated with physical activity in obese people.
abstract: OBJECTIVE
  To measure the amount of physical activity (PA) among obese adults, investigate the association between plasma orexin-A level and PA patterns, and explore the effect of orexin on the prevention and control of obesity.
  
  
  METHODS
  Interviews were conducted in 218 participants (106 obese; 73 overweight; and 39 normal) who ranged in age between 18 and 70 years using a survey that included sociodemographic variables. The International Physical Activity Questionnaire (IPAQ-long version) was used to measure PA. A total of 178 participants agreed to submit blood sample collections, and plasma orexin-A content was measured by ELISA testing.
  
  
  RESULTS
  The average level of orexin-A was 85.34 ± 42.85 ng/L in the obese group, 97.38 ± 36.72 ng/L in the overweight group, and 106.56 ± 52.09 ng/L in the control group, which was significantly different (P = 0.03). The concentration of plasma orexin-A correlated with the total PA (P = 0.000), moderate PA (obese = 0.007; overweight: P = 0.000; control: P = 0.000), and walking PA (P = 0.000) in all three groups. Working and domestic PAs were significantly associated with the plasma orexin-A level (P < 0.0001).
  
  
  CONCLUSIONS
  The plasma orexin-A level was associated with PA in obese and overweight people, including many aspects of daily life, such as working, domestic work, and walking especially.
authors.affiliation: School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Hao
authors.affiliation: School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China.
authors.forename: Hong-Wang
authors.initials: HW
authors.lastname: Yuan
authors.affiliation: School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China.
authors.forename: Peng-Hua
authors.initials: PH
authors.lastname: Fang
authors.affiliation: School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China.
authors.forename: Yue-Xia
authors.initials: YX
authors.lastname: Liao
authors.affiliation: Pediatric Cardiothoracic Surgical Department of Jiangsu Province Hospital, Nanjing, Jiangsu, The People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Shen
authors.affiliation: Colorectal Surgical Department of Jiangsu Province Hospital, Nanjing, Jiangsu, The People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Zhang
authors.affiliation: School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China. Boping1955@hotmail.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Bo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D000068797:Orexins / Q000097:blood*; D055815:Young Adult
chemical_list: D000068797:Orexins
keywords: Obesity; Orexin-A; Physical activity