title: Changes in choice evoked brain activations after a weight loss intervention in adolescents.
abstract: This study was aimed to investigate if treatment-related success in weight loss (i.e., reductions of BMI and fat percentage) is linked to significant changes in choice evoked brain activity in adolescents with excess weight. Sixteen adolescents with excess weight (age range: 12-18; BMI range: 22-36) performed the Risky-Gains Task during functional Magnetic Resonance Imaging (fMRI) both before and after a 12-week weight loss intervention. Success in weight loss was selectively associated with increased activation in the anterior insula. We concluded that adolescents with the greatest increases in activation of the insula-related interoceptive neural circuitry also show greater reductions in BMI and fat mass.
authors.affiliation: School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Melbourne, Australia.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Mata
authors.affiliation: Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Verdejo-Roman
authors.affiliation: Department of Psychiatry, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Barcelona, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Soriano-Mas
authors.affiliation: Brain & Mental Health Laboratory, School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia.
authors.forename: Murat
authors.initials: M
authors.lastname: Yücel
authors.affiliation: School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Melbourne, Australia; Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain. Electronic address: Antonio.Verdejo@monash.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: Verdejo-Garcia
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000294:Adolescent Behavior; D017195:Adolescent Nutritional Physiological Phenomena; D015992:Body Mass Index; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D002755:Choice Behavior; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003657:Decision Making; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009474:Neurons / Q000378:metabolism; D050177:Overweight / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D010349:Patient Compliance; D063766:Pediatric Obesity / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D012309:Risk-Taking; D015431:Weight Loss
keywords: Adolescents; Decision-making; Insula; Weight loss