title: Reduced Diagnostic Performance of Two Norovirus Antigen Enzyme Immunoassays for the Emergent Genogroup II Genotype 17 Kawasaki 2014 Variant.
abstract: Two commonly used norovirus enzyme immunoassays have reduced diagnostic performance, with clinical sensitivities ranging from 11% to 35% for the detection of the recently emerging genogroup II genotype 17 (GII.17) Kawasaki 2014 variant that caused the majority of infections in Asia during the winter of 2014 to 2015. False-negative results can compromise infection control and patient management.
authors.affiliation: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Martin C W
authors.initials: MCW
authors.lastname: Chan
authors.affiliation: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Kirsty
authors.initials: K
authors.lastname: Kwok
authors.affiliation: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Tin-Nok
authors.initials: TN
authors.lastname: Hung
authors.affiliation: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China paulkschan@cuhk.edu.hk.
authors.forename: Paul K S
authors.initials: PKS
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000032:analysis*; D001208:Asia; D017250:Caliciviridae Infections / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D019411:Clinical Laboratory Techniques / Q000379:methods*; D005188:False Negative Reactions; D005260:Female; D005838:Genotype; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D008297:Male; D008875:Middle Aged; D029322:Norovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D000956:Antigens, Viral