title: Electrophysiological alterations in a complex rat model of schizophrenia.
abstract: Psychiatric disorders are frequently accompanied by changes in brain electrical oscillations and abnormal auditory event related potentials. The goal of this study was to characterize these parameters of a new rat substrain showing several alterations related to schizophrenia.
  
  
  
  Male rats of the new substrain, developed by selective breeding after combined subchronic ketamine treatment and postweaning social isolation, and naive Wistar ones group-housed without any interventions were involved in the present study. At the age of 3 months, animals were implanted with cortical electroencephalography electrodes. Auditory evoked potentials during paired-click stimuli and power of oscillation in different frequency bands were determined with and without acute ketamine (20mg/kg) treatment.
  
  
  
  Regarding the auditory evoked potentials, the latency of P2 was delayed and the amplitude of N1 peak was lower in the new substrain. The new substrain showed increased power of oscillations in the theta, alpha and beta bands, while decreased power was detected in delta and gamma2 bands (52-70Hz) compared with control animals. Acute ketamine treatment increased the gamma1 band (30-48Hz) power in both groups, while it elicited significant changes only in the new substrain in the total power and in alpha, beta and gamma2 bands.
  
  
  
  The validation of the translational utility of this new rat substrain by electrophysiological investigations revealed that these rats show abnormalities that may model a part of the neurophysiological deficits observed in schizophrenia.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: horvath.gyongyi@med.u-szeged.hu.
authors.forename: Gyongyi
authors.initials: G
authors.lastname: Horvath
authors.affiliation: Institute of Physical Education and Sport Medicine, Juhász Gyula Faculty of Education, University of Szeged, Hattyas sor 10., H-6725 Szeged, Hungary. Electronic address: petrovszki.zita@med.u-szeged.hu.
authors.forename: Zita
authors.initials: Z
authors.lastname: Petrovszki
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: kekesi.gabriella@med.u-szeged.hu.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Kekesi
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6., H-6720 Szeged, Hungary. Electronic address: tuboly.gabor@med.u-szeged.hu.
authors.forename: Gabor
authors.initials: G
authors.lastname: Tuboly
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: bodosi.balazs@med.u-szeged.hu.
authors.forename: Balazs
authors.initials: B
authors.lastname: Bodosi
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: horvath.janos@med.u-szeged.hu.
authors.forename: Janos
authors.initials: J
authors.lastname: Horvath
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: gombpeti@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Gombkötő
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: benedek.gyorgy@med.u-szeged.hu.
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Benedek
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: nagy.attila.1@med.u-szeged.hu.
authors.forename: Attila
authors.initials: A
authors.lastname: Nagy
mesh_terms: D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000633:toxicity; D005260:Female; D005583:Fourier Analysis; D007649:Ketamine / Q000633:toxicity; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000209:etiology / Q000503:physiopathology*; D012934:Social Isolation / Q000523:psychology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine
keywords: Autism; Event related potentials; Neuronal oscillation; Power spectrum analysis; Rat model; Schizophrenia