title: Fatal Severe Fever with Thrombocytopenia Syndrome: An Autopsy Case Report.
abstract: As of June 2014, among six patients who had severe fever with thrombocytopenia syndrome (SFTS) at our hospital, an 83-year-old man died despite receiving appropriate critical care. An autopsy revealed extensive ischemic damage of the intra-abdominal organs, including the liver, spleen, stomach and gut, due to severe celiac atherosclerotic stenosis and superior mesenteric arterial thrombosis. Many SFTS virus nucleoprotein antigen-immunoreactive cells were detected in a paraaortic node, where necrotizing lymphadenitis was seen, and in the spleen. Fewer such cells were seen in the liver, bone marrow and adrenals.
  
  
  CONCLUSIONS
  Atherosclerosis, in addition to hemophagocytic lymphohistiocytosis syndrome, can be lethal in elderly SFTS patients.
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Uehara
authors.forename: Takao
authors.initials: T
authors.lastname: Yano
authors.forename: Akira
authors.initials: A
authors.lastname: Ishihara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saijou
authors.forename: Tadaki
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000209:etiology; D001344:Autopsy; D002044:Bunyaviridae Infections / Q000150:complications* / Q000503:physiopathology*; D017809:Fatal Outcome; D006801:Humans; D008199:Lymphadenitis / Q000209:etiology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D016856:Phlebovirus; D013577:Syndrome