title: Salbutamol in paediatrics: pharmacology, prescribing and controversies.
abstract: Salbutamol has become a key drug in respiratory medicine since it was first developed by Sir David Jack et al in 1968, 5000 years after the β agonist ephedrine was first used in its raw form, as the Ma Huang herb in Chinese medicine to treat asthma. It is one of the most commonly encountered medicines in paediatric practice and the authors have found that an understanding of its pharmacology in clinical practice is incredibly helpful. In this article, we discuss its pharmacology and pharmacodynamics, practical prescribing points and some unresolved issues surrounding its use, which should serve to provide an essential working knowledge for the busy paediatrician.
authors.affiliation: Sheffield Hand Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital, Sheffield, South Yorkshire, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Andrzejowski
authors.affiliation: Department of Respiratory Paediatrics, University Hospitals of North Midlands, Staffordshire, UK.
authors.forename: Will
authors.initials: W
authors.lastname: Carroll
mesh_terms: D000293:Adolescent; D000420:Albuterol / Q000494:pharmacology* / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D011307:Drug Prescriptions / Q000592:standards*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010372:Pediatrics / Q000592:standards*; D017410:Practice Guidelines as Topic
chemical_list: D000420:Albuterol
keywords: Accident & Emergency; General Paediatrics; Genetics; Pharmacology; Respiratory