title: Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs.
abstract: Thirty-four dogs with no deep pain perception due to acute thoracolumbar intervertebral disc disease underwent decompression surgery within 1 week of diagnosis. All dogs underwent hemilaminectomy. Adipose derived mesenchymal stem cells (AD-MSCs) were transplanted into the injured spinal cord parenchyma for the AD-MSCs transplant dogs. Long-term outcome was evaluated at the end of the follow-up period (> 6 months). AD-MSCs combination treatment showed better recovery outcomes compared to decompression surgery alone. These results indicate that this stem cell therapy is a potential therapeutic strategy to overcome the limitations of treatment for spinal cord injury in clinical medicine.
authors.affiliation: BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Yongsun
authors.initials: Y
authors.lastname: Kim
authors.affiliation: BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Wan Hee
authors.initials: WH
authors.lastname: Kim
authors.affiliation: BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Oh-Kyeong
authors.initials: OK
authors.lastname: Kweon
mesh_terms: D000208:Acute Disease; D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D019299:Decompression, Surgical / Q000662:veterinary; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D055959:Intervertebral Disc Degeneration / Q000628:therapy / Q000662:veterinary*; D007405:Intervertebral Disc Displacement / Q000628:therapy / Q000662:veterinary*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*; D058748:Pain Perception; D016896:Treatment Outcome
keywords: adipose derived mesenchymal stem cells; decompression surgery; dog; intervertebral disc disease