title: Intranasal T-LysYal® as adjunctive therapy for patients after functional endoscopic sinus surgery.
abstract: Functional Endoscopic Sinus Surgery (FESS) is a common day surgery technique for upper airway disorders. Hyaluronic acid (HA) is a fundamental component of the human connective tissue. HA may exert reparative, anti-inflammatory and immune-modulating activities. Recently, a new intranasal HA formulation has been proposed: a supramolecular system containing lysine hyaluronate, thymine and sodium chloride (T-LysYal®). This randomized study investigated whether intranasal T-LysYal® (RinoLysYal®, Farmigea, Italy) was able to reduce symptom severity, endoscopic features, and nasal cytology in 83 patients (49 males and 34 females mean age 45.4±6.2 years) treated with FESS. All patients were treated with isotonic saline solution for 4 weeks, and a sub-group (active group) was also treated with intranasal T-LysYal®. Patients were visited at baseline, after treatment, and after 4-week follow-up. Intranasal T-LysYal® treatment significantly reduced the quote of patients with symptoms, endoscopic features, and inflammatory cells in comparison to isotonic solution. In conclusion, the present study demonstrates that intranasal T-LysYal® is able to significantly improve patients after FESS and its effect is long lasting.
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gelardi
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Taliente
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Fiorella
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Quaranta
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: N
authors.initials: N
authors.lastname: De Candia
authors.affiliation: U.O.C. di Otorinolaringoiatria, Ospedale Di Venere, Carbonara Di Bari (BA), Italy.
authors.forename: C
authors.initials: C
authors.lastname: Russo
authors.affiliation: Division of Otolaryngology, Pinerolo and Rivoli Hospitals, ASL TO3, Pinerolo (TO), Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mola
authors.affiliation: Rhinology and Immuno-Allergy Unit, Sense Organs Department, Otolaryngology Section, Umberto I General Hospital, La Sapienza University, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ciofalo
authors.affiliation: Rhinology and Immuno-Allergy Unit, Sense Organs Department, Otolaryngology Section, Umberto I General Hospital, La Sapienza University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Zambetti
authors.affiliation: Department of Neuroscience, Reproductive and Dentistry Science, ENT Unit, Federico II University, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cantone
authors.affiliation: Clinica Otorinolaringoiatrica, Ospedale San Paolo, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Arnone
authors.affiliation: ORL Clinic University of Insubriae, Varese, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Macchi
authors.affiliation: S.C. Otorinolaringoiatra, Ospedale Civico di Chivasso (To), Italy.
authors.forename: P
authors.initials: P
authors.lastname: Rosso
authors.affiliation: Department of Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.) - Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ciprandi
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage* / Q000494:pharmacology*; D000281:Administration, Intranasal; D002452:Cell Count; D004724:Endoscopy; D004804:Eosinophils / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008239:Lysine / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D010256:Paranasal Sinuses / Q000473:pathology / Q000601:surgery*; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000494:pharmacology*; D013941:Thymine / Q000008:administration & dosage* / Q000494:pharmacology*; D014420:Turbinates / Q000187:drug effects / Q000473:pathology
chemical_list: D000277:Adjuvants, Pharmaceutic; C000608691:T-LysYal; D012965:Sodium Chloride; D008239:Lysine; D013941:Thymine