title: The effect of glucose administration on perceived fetal movements in women with decreased fetal movement, a double-blinded placebo-controlled trial.
abstract: To assess the effect of maternal glucose administration on perceived fetal movements.
  
  
  
  This was a randomized, double-blinded placebo-controlled trial. Patients 28-41 weeks singleton gestation complaining of decreased fetal movements (DFM) were assigned to receive either 500 cc dextrose 5% (group A) or 500 cc normal saline (group B) intravenously. Primary outcome was number of fetal movements recorded during the following 30 min. Secondary outcomes included need for admission or induction of labor owing to persistent DFM. Maternal glucose levels were taken before and after intervention. A sample size of 50 patients was planned in order to detect a 30% increase in fetal movements in group A.
  
  
  
  Between February 2011 and April 2013, 50 patients were recruited. Demographic characteristics were similar among groups. There was no difference in the number of fetal movements recorded (7±6 vs 8.8±6 movements/30 min, group A and B, respectively, P=0.39). Similar number of patients had persistent DFM that required admission (8 vs 10 patients, P=0.77, OR 1.4, confidence interval (CI) 0.38-5.3); of those admitted, similar number of patients had induction of labor (3 vs 6 patients, P=0.64, OR 0.4, CI 0.03-3.8). Maternal glucose levels were similar at recruitment (88±19 vs 83±15 mg dl(-1) P=0.36) but were significantly higher in group A (161±37 vs 75±15 mg dl(-1) P<0.0001) after intervention.
  
  
  
  In women with DFM, maternal glucose administration has no effect on perceived fetal movement and its clinical use is questionable.
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: N
authors.identifier: 0000-0001-7987-404X
authors.initials: N
authors.lastname: Michaan
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Baruch
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Topilsky
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Amzalag
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Iaskov
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Many
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Maslovitz
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D005324:Fetal Movement; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007557:Israel; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D005947:Glucose