title: Pancreatic Cysts in Autosomal Dominant Polycystic Kidney Disease: Prevalence and Association with PKD2 Gene Mutations.
abstract: Purpose To define the magnetic resonance (MR) imaging prevalence of pancreatic cysts in a cohort of patients with autosomal dominant polycystic kidney disease (ADPKD) compared with a control group without ADPKD that was matched for age, sex, and renal function. Materials and Methods In this HIPAA-compliant, institutional review board-approved study, all patients with ADPKD provided informed consent; for control subjects, informed consent was waived. Patients with ADPKD (n = 110) with mutations identified in PKD1 or PKD2 and control subjects without ADPKD or known pancreatic disease (n = 110) who were matched for age, sex, estimated glomerular filtration rate, and date of MR imaging examination were evaluated for pancreatic cysts by using axial and coronal single-shot fast spin-echo T2-weighted images obtained at 1.5 T. Total kidney volume and liver volume were measured. Univariate and multivariable logistic regression analyses were conducted to evaluate potential associations between collected variables and presence of pancreatic cysts among patients with ADPKD. The number, size, location, and imaging characteristics of the cysts were recorded. Results Patients with ADPKD were significantly more likely than control subjects to have at least one pancreatic cyst (40 of 110 patients [36%] vs 25 of 110 control subjects [23%]; P = .027). In a univariate analysis, pancreatic cysts were more prevalent in patients with ADPKD with mutations in PKD2 than in PKD1 (21 of 34 patients [62%] vs 19 of 76 patients [25%]; P = .0002). In a multivariable logistic regression model, PKD2 mutation locus was significantly associated with the presence of pancreatic cysts (P = .0004) and with liver volume (P = .038). Patients with ADPKD and a pancreatic cyst were 5.9 times more likely to have a PKD2 mutation than a PKD1 mutation after adjusting for age, race, sex, estimated glomerular filtration rate, liver volume, and total kidney volume. Conclusion Pancreatic cysts were more prevalent in patients with ADPKD with PKD2 mutation than in control subjects or patients with PKD1 mutation. (©) RSNA, 2016 Online supplemental material is available for this article.
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Jin Ah
authors.initials: JA
authors.lastname: Kim
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Jon D
authors.initials: JD
authors.lastname: Blumenfeld
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Shalini
authors.initials: S
authors.lastname: Chhabra
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Silvina P
authors.initials: SP
authors.lastname: Dutruel
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Nanda Deepa
authors.initials: ND
authors.lastname: Thimmappa
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Warren O
authors.initials: WO
authors.lastname: Bobb
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Stephanie
authors.initials: S
authors.lastname: Donahue
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Hanna E
authors.initials: HE
authors.lastname: Rennert
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Adrian Y
authors.initials: AY
authors.lastname: Tan
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Giambrone
authors.affiliation: From the Departments of Radiology (J.K., S.C., S.P.D., N.D.T., M.R.P.), Medicine (J.D.B.), Pathology (H.E.R., A.Y.T.), and Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College and New York Presbyterian Hospital, 416 E 55th St, New York, NY 10022; and the Rogosin Institute, New York, NY (J.D.B., W.O.B., S.D., H.E.R., A.Y.T.).
authors.forename: Martin R
authors.identifier: 0000-0002-9883-0584
authors.initials: MR
authors.lastname: Prince
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D005919:Glomerular Filtration Rate; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010181:Pancreatic Cyst / Q000000981:diagnostic imaging* / Q000235:genetics*; D016891:Polycystic Kidney, Autosomal Dominant / Q000000981:diagnostic imaging* / Q000235:genetics*; D015995:Prevalence; D012189:Retrospective Studies; D050396:TRPP Cation Channels / Q000235:genetics*
chemical_list: D050396:TRPP Cation Channels