title: Assessment of otoacoustic emission suppression in women with migraine and phonophobia.
abstract: Given that the medial olivocochlear efferent system reduces the amplitude of otoacoustic emissions (OAE), the aim of this study was to establish whether such a pathway is affected in women with migraine and phonophobia by means of OAE suppression testing. In this prospective case-control study, 55 women (29 with migraine and phonophobia and 26 healthy women) were subjected to transient-evoked otoacoustic emission (TEOAE) testing at frequencies from 1 to 4 kHz. The amplitudes of the TEOAE response before and after exposure to contralateral noise and the magnitude of TEOAE suppression were assessed. The average TEOAE amplitudes in conditions with and without exposure to contralateral noise were not significantly different between the groups. However, the magnitude of TEOAE suppression was lower in the group with migraine; that difference was only statistically significant for frequencies 1 and 1.5 kHz (p = 0.042 and p = 0.004, respectively). In this study, women with migraine and phonophobia exhibited deficits in OAE suppression, which points to a disorder affecting the medial olivocochlear efferent system.
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Engenheiro Pena Chaves, 85/301, Rio de Janeiro, RJ, 22460-090, Brazil. luciajoffily@gmail.com.
authors.forename: Lucia
authors.initials: L
authors.lastname: Joffily
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Engenheiro Pena Chaves, 85/301, Rio de Janeiro, RJ, 22460-090, Brazil.
authors.forename: Marco Antônio
authors.initials: MA
authors.lastname: de Melo Tavares de Lima
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Engenheiro Pena Chaves, 85/301, Rio de Janeiro, RJ, 22460-090, Brazil.
authors.forename: Maurice Borges
authors.initials: MB
authors.lastname: Vincent
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Engenheiro Pena Chaves, 85/301, Rio de Janeiro, RJ, 22460-090, Brazil.
authors.forename: Silvana Maria Monte Coelho
authors.initials: SM
authors.lastname: Frota
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality; D006801:Humans; D012001:Hyperacusis / Q000503:physiopathology*; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D011446:Prospective Studies; D011571:Psychoacoustics; D055815:Young Adult
keywords: Hyperacusis; Hyperexcitability; Migraine; Otoacoustic emission; Phonophobia