title: Hepatoblastoma: A Need for Cell Lines and Tissue Banks to Develop Targeted Drug Therapies.
abstract: Limited research exists regarding the most aggressive forms of hepatoblastoma. Cell lines of the rare subtypes of hepatoblastoma with poor prognosis are not only difficult to attain but also challenging to characterize histologically. A community-driven approach to educating parents and families, regarding the need for donated tissue, is necessary for scientists to have access to resources for murine models and drug discovery. Herein, we describe the currently available resources, existing gaps in research, and the path to move forward for uniform cure of hepatoblastoma.
authors.affiliation: Children's Cancer Therapy Development Institute , Beaverton, OR , USA.
authors.forename: Rishi Raj
authors.initials: RR
authors.lastname: Rikhi
authors.affiliation: Faculty of the 2015 Pediatric Cancer Biology Nanocourse, Children's Cancer Therapy Development Institute , Fort Collins, CO , USA.
authors.forename: Kimberlee K
authors.initials: KK
authors.lastname: Spady
authors.affiliation: Faculty of the 2015 Pediatric Cancer Biology Nanocourse, Children's Cancer Therapy Development Institute , Fort Collins, CO , USA.
authors.forename: Ruth I
authors.initials: RI
authors.lastname: Hoffman
authors.affiliation: Faculty of the 2015 Pediatric Cancer Biology Nanocourse, Children's Cancer Therapy Development Institute , Fort Collins, CO , USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bateman
authors.affiliation: Faculty of the 2015 Pediatric Cancer Biology Nanocourse, Children's Cancer Therapy Development Institute , Fort Collins, CO , USA.
authors.forename: Max
authors.initials: M
authors.lastname: Bateman
authors.affiliation: Faculty of the 2015 Pediatric Cancer Biology Nanocourse, Children's Cancer Therapy Development Institute , Fort Collins, CO , USA.
authors.forename: Lisa Easom
authors.initials: LE
authors.lastname: Howard
keywords: cell lines; hepatoblastoma; roadmap; tissue procurement; xenograft models