title: Cell and gene therapy strategies to eradicate HIV reservoirs.
abstract: Highly active antiretroviral treatment has dramatically improved the prognosis for people living with HIV by preventing AIDS-related morbidity and mortality through profound suppression of viral replication. However, a long-lived viral reservoir persists in latently infected cells that harbor replication-competent HIV genomes. If therapy is discontinued, latently infected memory cells inevitably reactivate and produce infectious virus, resulting in viral rebound. The reservoir is the biggest obstacle to a cure of HIV.
  
  
  
  This review summarizes significant advances of the past year in the development of cellular and gene therapies for HIV cure. In particular, we highlight work done on suppression or disruption of HIV coreceptors, vectored delivery of antibodies and antibody-like molecules, T-cell therapies and HIV genome disruption.
  
  
  
  Several recent advancements in cellular and gene therapies have emerged at the forefront of HIV cure research, potentially having broad implications for the future of HIV treatment.
authors.affiliation: aVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA bDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
authors.forename: Chelsea
authors.initials: C
authors.lastname: Spragg
authors.forename: Harshana
authors.initials: H
authors.lastname: De Silva Feelixge
authors.forename: Keith R
authors.initials: KR
authors.lastname: Jerome
mesh_terms: D035843:Biomedical Research / Q000639:trends; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D015658:HIV Infections / Q000628:therapy* / Q000821:virology*; D006801:Humans; D017735:Virus Latency