title: Keeping it simple: lessons from the golden era of antibiotic discovery.
abstract: Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time, little progress has been made in discovering new antibacterial drugs to combat resistant organisms. History teaches us that 'high tech' target-based complex methods are not synonymous with success and a return to simple, systematic screening of natural products against bacteria from traditional and novel resources holds our greatest hope of success.
authors.affiliation: School of Science and Technology, University of New England, Armidale NSW 2351, Australia dlyddiar@myune.edu.au.
authors.forename: Dane
authors.initials: D
authors.lastname: Lyddiard
authors.affiliation: School of Science and Technology, University of New England, Armidale NSW 2351, Australia.
authors.forename: Graham L
authors.initials: GL
authors.lastname: Jones
authors.affiliation: School of Science and Technology, University of New England, Armidale NSW 2351, Australia.
authors.forename: Ben W
authors.initials: BW
authors.lastname: Greatrex
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics; D001688:Biological Products / Q000494:pharmacology*; D055808:Drug Discovery / Q000379:methods*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products
keywords: antibacterial; antibiotic; drug discovery; history; natural products; screening