title: Cross-validation and Peeling Strategies for Survival Bump Hunting using Recursive Peeling Methods.
abstract: We introduce a framework to build a survival/risk bump hunting model with a censored time-to-event response. Our Survival Bump Hunting (SBH) method is based on a recursive peeling procedure that uses a specific survival peeling criterion derived from non/semi-parametric statistics such as the hazards-ratio, the log-rank test or the Nelson--Aalen estimator. To optimize the tuning parameter of the model and validate it, we introduce an objective function based on survival or prediction-error statistics, such as the log-rank test and the concordance error rate. We also describe two alternative cross-validation techniques adapted to the joint task of decision-rule making by recursive peeling and survival estimation. Numerical analyses show the importance of replicated cross-validation and the differences between criteria and techniques in both low and high-dimensional settings. Although several non-parametric survival models exist, none addresses the problem of directly identifying local extrema. We show how SBH efficiently estimates extreme survival/risk subgroups unlike other models. This provides an insight into the behavior of commonly used models and suggests alternatives to be adopted in practice. Finally, our SBH framework was applied to a clinical dataset. In it, we identified subsets of patients characterized by clinical and demographic covariates with a distinct extreme survival outcome, for which tailored medical interventions could be made. An R package PRIMsrc (Patient Rule Induction Method in Survival, Regression and Classification settings) is available on CRAN (Comprehensive R Archive Network) and GitHub.
authors.affiliation: Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Jean-Eudes
authors.initials: JE
authors.lastname: Dazard
authors.affiliation: Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Choe
authors.affiliation: Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA 98195, USA; Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: LeBlanc
authors.affiliation: Division of Biostatistics, Department of Epidemiology and Public Health, The University of Miami, Miami, FL 33136, USA.
authors.forename: J Sunil
authors.initials: JS
authors.lastname: Rao
keywords: Bump Hunting; Cross-Validation; Exploratory Survival/Risk Analysis; Non-Parametric Method; Patient Rule-Induction Method; Survival/Risk Estimation & Prediction