title: Effect of atmospheric fine particles on epidermal growth factor receptor mRNA expression in mouse skin tissue.
abstract: We investigated the effect of atmospheric fine particles on epidermal growth factor receptor (Egfr) mRNA expression in mouse skin tissue and explored the effect of atmospheric fine particles on skin aging. Forty female BALB/c mice were randomly divided into four groups (each comprising 10 mice) as follows: a saline control group and low-, medium-, and high-dose atmospheric fine particle groups (1.6, 8.0, and 40.0 mg/kg, respectively) (fine particles were defined as those with a diameter of £2.5 mm, i.e., PM2.5). Each dose group was exposed to intratracheal instillation for 3 days. Twenty-four hours after the last exposure, real-time quantitative polymerase chain reaction was used to detect the expression of Egfr mRNA in the skin tissue of each mouse. The expression levels of Egfr mRNA in the medium- and high-dose PM2.5 groups were significantly higher (P < 0.05) than that in the control group, and were positively correlated with the dose. Medium and high concentrations of PM2.5 can induce the expression of Egfr mRNA and promote skin aging.
authors.affiliation: Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.|The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: X
authors.initials: X
authors.lastname: Han
authors.affiliation: Nursing School of Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: W L
authors.initials: WL
authors.lastname: Liang
authors.affiliation: Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: L D
authors.initials: LD
authors.lastname: Sun
authors.affiliation: College of Environmental Science & Engineering, Beijing Forestry University, Beijing, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Liang
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D052638:Particulate Matter / Q000009:adverse effects*; D012333:RNA, Messenger / Q000235:genetics*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D052638:Particulate Matter; D012333:RNA, Messenger; D066246:ErbB Receptors