title: Changes in Synaptic Transmission and Long-term Potentiation Induction as a Possible Mechanism for Learning Disability in an Animal Model of Multiple Sclerosis.
abstract: OBJECTIVE
  Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. It has been shown that memory deficits is common in patients with MS. Recent studies using experimental autoimmune encephalomyelitis (EAE) as an animal model of MS have shown that indicated that EAE causes hippocampal-dependent impairment in learning and memory. Thus far, there have been no in vivo electrophysiological reports describing synaptic transmission in EAE animals. The aim of the present work is to evaluate the synaptic changes in the CA1 region of the hippocampus of EAE rats.
  
  
  METHODS
  To evaluate changes in synaptic transmission in the CA1 region of the hippocampus of EAE rats, field excitatory postsynaptic potentials (fEPSPs) from the stratum radiatum of CA1 neurons, were recorded following Schaffer collateral stimulation.
  
  
  RESULTS
  The results showed that EAE causes deficits in synaptic transmission and long-term potentiation (LTP) in the hippocampus. In addition, paired-pulse index with a 120 msec interstimulus interval was decreased in the EAE group. These findings indicate that EAE might induce suppression in synaptic transmission and LTP by increasing the inhibitory effect of GABAB receptors on the glutamate-mediated EPSP.
  
  
  CONCLUSIONS
  In conclusion, influence of inflammation-triggered mechanisms on synaptic transmission may explain the negative effect of EAE on learning abilities in rats.
authors.affiliation: Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Ghasem
authors.identifier: 0000-0003-3877-0783
authors.initials: G
authors.lastname: Mosayebi
authors.affiliation: Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Mohammad Reza
authors.identifier: 0000-0002-8224-4222
authors.initials: MR
authors.lastname: Soleyman
authors.affiliation: Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Mostafa
authors.identifier: 0000-0001-9298-2811
authors.initials: M
authors.lastname: Khalili
authors.affiliation: Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Masoumeh
authors.identifier: 0000-0003-3620-8084
authors.initials: M
authors.lastname: Mosleh
authors.affiliation: Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Mohammad Reza
authors.identifier: 0000-0001-7655-944X
authors.initials: MR
authors.lastname: Palizvan
keywords: Encephalomyelitis, Autoimmune, Experimental; Hippocampus; Long-term Potentiation; Paired Pulse Index