title: Trace metal levels in serum and urine of a population in southern Brazil.
abstract: This study aimed to evaluate serum and urine concentrations of several trace metals of a non-directly exposed population in southern Brazil and establish reference values. Serum and urine samples were obtained from 240 volunteers (175 males and 65 females, age ranging from 18 to 74 years old). Levels of arsenic, chromium, cobalt, copper, lead, nickel, manganese and zinc were determined by means of dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS). Comparison between genders resulted in no significant difference for all metals but serum copper, as concentrations are higher in females than males. For most metals assessed, a negative correlation between serum concentrations and age was found, but no significant correlation was found between urine concentrations and age.
authors.affiliation: Laboratory of Toxicology, Course of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: G H O
authors.initials: GH
authors.lastname: Rocha
authors.affiliation: Laboratory of Toxicology, Course of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Steinbach
authors.affiliation: Laboratory of Toxicology, Course of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: J R
authors.initials: JR
authors.lastname: Munhoz
authors.affiliation: Laboratory of Toxicology, Course of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: M A O
authors.initials: MA
authors.lastname: Madia
authors.affiliation: Laboratory of Toxicology, Course of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: J K
authors.initials: JK
authors.lastname: Faria
authors.affiliation: Laboratory of Toxicology, Course of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Hoeltgebaum
authors.affiliation: Laboratory of Metal Toxicology and Essentiality, Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Barbosa
authors.affiliation: Laboratory of Metal Toxicology and Essentiality, Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Natural and Human Sciences Centre, Federal University of the ABC, Santo André, São Paulo, Brazil.
authors.forename: B L
authors.initials: BL
authors.lastname: Batista
authors.affiliation: Laboratory of Metal Toxicology and Essentiality, Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: V C O
authors.initials: VC
authors.lastname: Souza
authors.affiliation: Laboratory of Toxicology, Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: S B
authors.initials: SB
authors.lastname: Nerilo
authors.affiliation: Laboratory of Toxicology, Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Bando
authors.affiliation: Laboratory of Toxicology, Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: S A G
authors.initials: SA
authors.lastname: Mossini
authors.affiliation: Laboratory of Toxicology, Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil. Electronic address: pnishiyama@uem.br.
authors.forename: P
authors.initials: P
authors.lastname: Nishiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D014131:Trace Elements / Q000097:blood* / Q000652:urine*; D055815:Young Adult
chemical_list: D014131:Trace Elements
keywords: Dynamic reaction cell inductively coupled plasma mass spectrometry; Fluid analyses; Non-occupational exposure; Population studies