title: MAFdrives CD8+T-cell exhaustion.
abstract: The molecular regulation of tumor induced T-cell exhaustion remains poorly characterized. Recently, we compared the transcriptome of "exhausted" CD8+T cells infiltrating melanomas to those of naive and acutely stimulated CD8+T cells. We demonstrated thatMAFis over-expressed and plays a key role in driving the transcriptional program of T-cell exhaustion.
authors.affiliation: Department of Oncology and Ludwig Cancer Research Center, University of Lausanne , Biopole 3, Ch. des Boveresses 155 , Epalinges, Switzerland.
authors.forename: Grégory
authors.initials: G
authors.lastname: Verdeil
keywords: CD8+ T cell; exhaustion; maf; melanoma