title: The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment.
abstract: The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany. Electronic address: katharina.brueggen@dzne.de.
authors.forename: Katharina
authors.initials: K
authors.lastname: Brueggen
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany.
authors.forename: Michel J
authors.initials: MJ
authors.lastname: Grothe
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany; MMIS Group, University of Rostock, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Dyrba
authors.affiliation: Department of Psychiatry, University Medical Center Mainz, Mainz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Fellgiebel
authors.affiliation: Department of Psychiatry, University Medical Center Mainz, Mainz, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Fischer
authors.affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Vita-Salute San Raffaele, Milano, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
authors.affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Vita-Salute San Raffaele, Milano, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Agosta
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Magdeburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Nestor
authors.affiliation: Department of Psychiatry, Ludwig Maximilian University, Munich, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Meisenzahl
authors.affiliation: Institute for Clinical Radiology, Department of MRI, Ludwig Maximilian University, Munich, Germany.
authors.forename: Janusch
authors.initials: J
authors.lastname: Blautzik
authors.affiliation: Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Lutz
authors.initials: L
authors.lastname: Frölich
authors.affiliation: Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Hausner
authors.affiliation: Cognitive Systems Group, Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience (TCIN), Trinity College Dublin, Dublin, Ireland.
authors.forename: Arun L W
authors.initials: ALW
authors.lastname: Bokde
authors.affiliation: Laboratory of Epidemiology, Neuroimaging and Telemedicine (LENITEM), IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Frisoni
authors.affiliation: Laboratory of Epidemiology, Neuroimaging and Telemedicine (LENITEM), IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Pievani
authors.affiliation: Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Klöppel
authors.affiliation: Laboratory of Neurophysiology und Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt/Main, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Prvulovic
authors.affiliation: Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Centre, The Netherlands.
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.affiliation: Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Centre, The Netherlands.
authors.forename: Petra J W
authors.initials: PJW
authors.lastname: Pouwels
authors.affiliation: Section of Geriatric Psychiatry, University of Heidelberg, Heidelberg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schröder
authors.affiliation: AXA Research Fund & UPMC Chair, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie, Paris, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
authors.forename: Harald
authors.initials: H
authors.lastname: Hampel
authors.affiliation: Department of Radiology, University of Rostock, Rostock, Germany.
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Hauenstein
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany; Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Teipel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D033181:Information Dissemination; D008297:Male; D008875:Middle Aged
keywords: Alzheimer's disease; Data sharing; Diffusion tensor imaging; Mild cognitive impairment; Multicenter study