title: [Establishment of a miniature pig model of mandibular osteoradionecrosis].
abstract: OBJECTIVE
  To establish a miniature pig model of mandibular osteoradionecrosis (ORN).
  
  
  METHODS
  A single dose of irradiation (IR25 Gy, 28 Gy) was delivered via an electronic linear accelerator to the right mandible of 24 miniature pigs by utilizing three dimensional conformal radiotherapy (3D-CRT). The first molar of the mandible was extracted 2 months after radiation. Mandibular ORN was diagnosed through gross observation, X-ray film, CT, and histopathologic examination.
  
  
  RESULTS
  At 3-4 months after radiation, all animals suffered from mandibular ORN after dental extraction. The symptoms of ORN were more severe in the 28 Gy group than in the 25 Gy group.
  
  
  CONCLUSIONS
  A miniature pig model of mandibular ORN can be established through 25 Gy irradiation + dental extraction.
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.forename: Fang
authors.initials: F
authors.lastname: Dianji
authors.forename: Wang
authors.initials: W
authors.lastname: Zhanyi
authors.forename: Zhai
authors.initials: Z
authors.lastname: Lulu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhaorong
authors.forename: Guo
authors.initials: G
authors.lastname: Yanwei
mesh_terms: D000818:Animals; D008334:Mandible; D008336:Mandibular Diseases / Q000473:pathology*; D008963:Molar; D010025:Osteoradionecrosis / Q000473:pathology*; D010315:Particle Accelerators; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D020266:Radiotherapy, Conformal / Q000009:adverse effects; D013552:Swine; D013556:Swine, Miniature; D014081:Tooth Extraction