title: Glutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia-Induced vascular dementia of rats.
abstract: Chronic cerebral ischemia (CCI) is associated with cognitive decline in aging, vascular dementia and Alzheimer's disease. Substantial evidence has shown that chronic cerebral ischemia may cause cognitive impairment, but the underlying neurobiological mechanism is poorly understood so far. In the present study, we used a rat model of chronic cerebral ischemia by permanent bilateral common carotid artery occlusion (BCCAO) to investigate the alterations of glutamatergic and central cholinergic dysfunction, and their causal relationship with the cognitive deficits induced by chronic cerebral ischemia. We found that BCCAO rats exhibited spatial learning and memory impairments dysfunction 3 month after BCCAO. Meanwhile, vGluT levels as well as glutamatergic and central cholinergic positive neurons in the hippocampus CA1-3 field significantly decreased. The protection of glutamergic and cholinergic neurons or regulating glutamate and central cholinergic levels in hippocampal subregion may have beneficial effects on cognitive impairments associated with the possible mechanism in CCI-induced vascular dementia.
authors.affiliation: Department of Neurology, Hangzhou Third Hospital, 38 xihu Road, Hangzhou 310009, PR China.
authors.forename: Yanjing
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Weifang Second People's Hospital, 7 Yuanxiao Street, WeiFang, Shandong 261041, PR China.
authors.forename: Zengmei
authors.initials: Z
authors.lastname: Gou
authors.affiliation: Department of Neurology, Shandong Provincial Hospital, Shandong University, 44 Wenhua xi Road, Jinan 2500013, PR China. Electronic address: duyifeng2014@163.com.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Du
authors.affiliation: Eskitis institute for drug discovery, Griffith University, QLD 4111, Australia.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Neurology, Hangzhou Third Hospital, 38 xihu Road, Hangzhou 310009, PR China.
authors.forename: Lizhen
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Neurology, Hangzhou Third Hospital, 38 xihu Road, Hangzhou 310009, PR China.
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Neurology, Hangzhou Third Hospital, 38 xihu Road, Hangzhou 310009, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Neurology, Hangzhou Third Hospital, 38 xihu Road, Hangzhou 310009, PR China.
authors.forename: Mudan
authors.initials: M
authors.lastname: Jin
authors.affiliation: Department of Neurology, Shandong Provincial Hospital, Shandong University, 44 Wenhua xi Road, Jinan 2500013, PR China.
authors.forename: Yifenf
authors.initials: Y
authors.lastname: Du
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications*; D056547:CA1 Region, Hippocampal / Q000378:metabolism*; D056651:CA2 Region, Hippocampal / Q000378:metabolism*; D056654:CA3 Region, Hippocampal / Q000378:metabolism*; D002908:Chronic Disease; D015140:Dementia, Vascular / Q000209:etiology / Q000378:metabolism / Q000523:psychology*; D018782:Maze Learning; D008568:Memory; D009474:Neurons / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D065853:Spatial Learning; D050494:Vesicular Acetylcholine Transport Proteins / Q000378:metabolism*; D050496:Vesicular Glutamate Transport Proteins / Q000378:metabolism*; D050495:Vesicular Inhibitory Amino Acid Transport Proteins / Q000378:metabolism*
chemical_list: D050494:Vesicular Acetylcholine Transport Proteins; D050496:Vesicular Glutamate Transport Proteins; D050495:Vesicular Inhibitory Amino Acid Transport Proteins; C493406:vesicular GABA transporter
keywords: CA1; CA2; CA3; Vascular dementia; vAChT; vGlut(1); vGlut(3)