title: HOXs and lincRNAs: Two sides of the same coin.
abstract: The clustered Hox genes play fundamental roles in regulation of axial patterning and elaboration of the basic body plan in animal development. There are common features in the organization and regulatory landscape of Hox clusters associated with their highly conserved functional roles. The presence of transcribed noncoding sequences embedded within the vertebrate Hox clusters is providing insight into a new layer of regulatory information associated with Hox genes.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
authors.forename: Bony
authors.identifier: 0000-0001-8398-3775
authors.initials: B
authors.lastname: De Kumar
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO 64110, USA.; Department of Anatomy and Cell Biology, Kansas University Medical Center, Kansas City, KS 66160, USA.
authors.forename: Robb
authors.initials: R
authors.lastname: Krumlauf
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D005801:Genes, Homeobox; D006801:Humans; D005810:Multigene Family; D062085:RNA, Long Noncoding; D015533:Transcriptional Activation
chemical_list: D062085:RNA, Long Noncoding
keywords: Hox genes; gene regulation; lincRNAs; non-coding RNAs