title: TBS Predict Coronary Artery Calcification in Adults.
abstract: OBJECTIVE
  This study analyzes the association between the bony microarchitecture score (trabecular bone score, TBS) and coronary artery calcification (CAC) in adults undergoing health exams.
  
  
  METHODS
  We retrospectively collected subjects (N = 81) who underwent coronary computed tomography and bone mineral density studies simultaneously. CAC was categorized to three levels (Group 0, G0, no CAC, score = 0, N = 45; Group 1, G1, moderate CAC, score = 1-100, N = 17; Group 2, G2, high CAC, score ≧ 101, N = 19). Multinomial logistic regression was used to study the association between TBS and CAC levels.
  
  
  RESULTS
  CAC is present in 44.4% of the population. Mean TBS ± SD was 1.399 ± 0.090. Per 1 SD increase in TBS, the unadjusted odds ratio (2.393) of moderate CAC compared with no CAC was significantly increased (95% CI, 1.219-4.696, p = 0.011). However, there has been no association of TBS with high CAC (OR: 1.026, 95% CI: 0.586-1.797, p = 0.928). These relationships also existed when individually adjusted for age, sex, and multiple other covariates.
  
  
  CONCLUSIONS
  Higher TBS was related to moderate CAC, but not high CAC; a possible explanation may be that bone microarchitecture remodeling becomes more active when early coronary artery calcification occurs. However, further researches are needed to clarify this pathophysiology.
authors.affiliation: Department of Nuclear Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
authors.forename: Tzyy-Ling
authors.initials: TL
authors.lastname: Chuang
authors.affiliation: Department of Medical Imaging, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
authors.forename: Fu-Tsung
authors.initials: FT
authors.lastname: Hsiao
authors.affiliation: Department of Cardiology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
authors.forename: Yi-Da
authors.initials: YD
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Yuh-Feng
authors.identifier: 0000-0002-0403-0536
authors.initials: YF
authors.lastname: Wang
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015519:Bone Density; D002114:Calcinosis / Q000503:physiopathology*; D000071556:Cancellous Bone / Q000503:physiopathology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification / Q000000981:diagnostic imaging / Q000503:physiopathology