title: Krebs Cycle Moonlights in Caspase Regulation.
abstract: In this issue of Developmental Cell, Aram et al. (2016) identify a mechanism that uses a Krebs cycle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer membrane for temporally and spatially restricted caspase activation during Drosophila sperm differentiation.
authors.affiliation: Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Adi
authors.initials: A
authors.lastname: Minis
authors.affiliation: Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: steller@mail.rockefeller.edu.
authors.forename: Hermann
authors.initials: H
authors.lastname: Steller
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism*; D002952:Citric Acid Cycle / Q000502:physiology*; D044842:Cullin Proteins / Q000378:metabolism*; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D013087:Spermatids / Q000378:metabolism*
chemical_list: D044842:Cullin Proteins; D029721:Drosophila Proteins; D020169:Caspases