title: [Neurocognitive Disorders Caused by Central Nervous System Lupus Erythematosus].
abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple biological systems that has primary and secondary effects on the central nervous system. Neuropsychiatric manifestations of SLE (NPSLE) are common and are associated with a worse prognosis, more cumulative organ damage, and decreased quality of life. The neurocognitive disorders of NPSLE include an acute confusional state and cognitive dysfunction. The pathogenic mechanisms underlying NPSLE are likely to be multifactorial and may involve vasculopathy of predominantly small intracranial blood vessels, autoantibody production, and intrathecal production of proinflammatory cytokines. No disease-specific diagnostic markers or diagnostic gold standard is known for NPSLE. Thus, the first step of the diagnostic work-up is to exclude non-SLE-related conditions. The correct diagnosis is derived from careful analysis of the clinical, laboratory, and imaging data on a case-by-case basis. This article reviews the current literature, especially on the neurocognitive disorders of NPSLE.
authors.affiliation: Department of Psychiatry, Tokyo Women's Medical University, School of Medicine.
authors.forename: Katsuji
authors.initials: K
authors.lastname: Nishimura
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D020945:Lupus Vasculitis, Central Nervous System / Q000209:etiology* / Q000276:immunology / Q000628:therapy*; D011788:Quality of Life
chemical_list: D001323:Autoantibodies