title: Insulin Signaling in a Bit of a Jam.
abstract: In this issue of Cell, Okin and Medzhitov report that sustained inflammation promotes hyperglycemia by targeting the mevalonate pathway. This represents an important step forward in understanding the mechanisms underlying the association between chronic low-grade inflammation and disruption of normal tissue functions in metabolic diseases.
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.
authors.forename: Vassily I
authors.initials: VI
authors.lastname: Kutyavin
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA; Departments of Physiology and Medicine, University of California, San Francisco, San Francisco, CA 94158-9001, USA. Electronic address: ajay.chawla@ucsf.edu.
authors.forename: Ajay
authors.initials: A
authors.lastname: Chawla
mesh_terms: D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D007328:Insulin; D008659:Metabolic Diseases; D015398:Signal Transduction
chemical_list: D007328:Insulin