title: Outbreak of influenza-like illness investigated during August 2013 near Indo-China border of Arunachal Pradesh, Northeast India.
abstract: During August 2013, an outbreak of influenza-like illnesses (ILI) was investigated in Monigong area, near Indo-China border of Arunachal Pradesh, Northeast India. Influenza type A/H3N2 was detected by RT-PCR in 33.3% (8/24) of ILI cases. Sequence analysis of HA and NA genes revealed eight and five amino acid substitutions, respectively in Monigong H3N2 (Mo/H3N2) strains as compared to vaccine strain A/Victoria/361/2011. Four non-synonymous substitutions, three localizing at antigenic sites T144A, A; R158G, B; L173S, D, and one H9Y in close proximity to a potential glycosylation site aa8 in HA1 domain along with the substitution T329N in NA are likely to influence the antigenicity/virulence of Mo/H3N2 viruses. J. Med. Virol. 88:1999-2003, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Regional Medical Research Centre, North East Region, Indian Council of Medical Research, Dibrugarh, Assam, India.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Biswas
authors.affiliation: Regional Medical Research Centre, North East Region, Indian Council of Medical Research, Dibrugarh, Assam, India.
authors.forename: Manika
authors.initials: M
authors.lastname: Buragohain
authors.affiliation: Regional Medical Research Centre, North East Region, Indian Council of Medical Research, Dibrugarh, Assam, India.
authors.forename: Kaushal
authors.initials: K
authors.lastname: Yadav
authors.affiliation: Regional Medical Research Centre, North East Region, Indian Council of Medical Research, Dibrugarh, Assam, India.
authors.forename: Mousumi
authors.initials: M
authors.lastname: Dutta
authors.affiliation: Regional Medical Research Centre, North East Region, Indian Council of Medical Research, Dibrugarh, Assam, India.
authors.forename: Kimmi
authors.initials: K
authors.lastname: Sarmah
authors.affiliation: Regional Medical Research Centre, North East Region, Indian Council of Medical Research, Dibrugarh, Assam, India.
authors.forename: Pranjal Jyoti
authors.initials: PJ
authors.lastname: Baruah
authors.affiliation: Regional Medical Research Centre, North East Region, Indian Council of Medical Research, Dibrugarh, Assam, India.
authors.forename: Biswajyoti
authors.initials: B
authors.lastname: Borkakoty
mesh_terms: D000293:Adolescent; D019943:Amino Acid Substitution; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D014644:Genetic Variation; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D008297:Male; D009439:Neuraminidase / Q000235:genetics; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D012367:RNA, Viral; D009439:Neuraminidase
keywords: H3N2; ILI; influenza