title: The association between osteoporotic hip fractures and actinic lesions as a biomarker for cumulative sun exposure in older people-a retrospective case-control study in Argentina.
abstract: The aim of this study was to analyze the association between the presence of actinic lesions (solar keratosis and non-melanoma skin cancer) and osteoporotic hip fractures in older patients. Both pathologies are common conditions in this age group. Since cumulative sun exposure is difficult to quantify, the presence of actinic lesions can be used to indirectly analyze the association between ultraviolet radiation and osteoporotic hip fractures. This was an observational case-control study. We reviewed the centralized medical records of patients with hip fracture (cases, n = 51) and patients with other diseases hospitalized in the same institution and period (controls, n = 59). The mean age of the patients was 80 ± 8.3 years (range 50-103 years). Differences in maternal hip fracture history were found between cases and controls (14.8 and 8 %, respectively; p = 0.047). Falls history in the past year was higher in cases than in controls (p < 0.0001). Actinic lesions were observed in 32.7 % of patients (prevalence rate 23.5 % in cases, 40.7 % in controls; p = 0.04). When considering patients with actinic lesions, controls have a higher FRAX score compared with cases. Although sun exposure is recommended for bone health, it represents a risk factor for actinic lesions. The presence of actinic lesions may indicate a lower osteoporotic hip fracture risk. A balance between adequate lifetime sun exposure and protection against its adverse effects is required for each patient, in the context of geographic location.
authors.affiliation: Area Instrumental Metodología de la Investigación Científica, Facultad de Ciencias Médicas (FCM), Universidad Nacional de Rosario (UNR), Santa Fe 3100, 2000, Rosario, Argentina.|Instituto de Genética Experimental FCM, UNR, Rosario, Argentina.
authors.forename: H A
authors.initials: HA
authors.lastname: Perroud
authors.affiliation: Area Instrumental Metodología de la Investigación Científica, Facultad de Ciencias Médicas (FCM), Universidad Nacional de Rosario (UNR), Santa Fe 3100, 2000, Rosario, Argentina.|Cátedra de Dermatología, FCM, UNR, Rosario, Argentina.
authors.forename: M S
authors.initials: MS
authors.lastname: Dagatti
authors.affiliation: Policlínico PAMI II, Rosario, Argentina.
authors.forename: B
authors.initials: B
authors.lastname: Amigot
authors.affiliation: Policlínico PAMI II, Rosario, Argentina.|Cátedra de Clínica Médica, FCM, UNR, Rosario, Argentina.
authors.forename: G P
authors.initials: GP
authors.lastname: Levit
authors.affiliation: Cátedra de Química Biológica, FCM, UNR, Rosario, Argentina.
authors.forename: M F
authors.initials: MF
authors.lastname: Tomat
authors.affiliation: Cátedra de Química Biológica, FCM, UNR, Rosario, Argentina.
authors.forename: M E
authors.initials: ME
authors.lastname: Morosano
authors.affiliation: Area Instrumental Metodología de la Investigación Científica, Facultad de Ciencias Médicas (FCM), Universidad Nacional de Rosario (UNR), Santa Fe 3100, 2000, Rosario, Argentina.|Cátedra de Química Biológica, FCM, UNR, Rosario, Argentina.
authors.forename: A M
authors.initials: AM
authors.lastname: Masoni
authors.affiliation: Area Instrumental Metodología de la Investigación Científica, Facultad de Ciencias Médicas (FCM), Universidad Nacional de Rosario (UNR), Santa Fe 3100, 2000, Rosario, Argentina. spezzotto@gmail.com.|Consejo de Investigaciones, UNR, Rosario, Argentina. spezzotto@gmail.com.
authors.forename: S M
authors.initials: SM
authors.lastname: Pezzotto
mesh_terms: D000058:Accidental Falls; D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina / Q000453:epidemiology; D015415:Biomarkers / Q000378:metabolism*; D016022:Case-Control Studies; D003611:Dairy Products; D005260:Female; D006620:Hip Fractures / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D055623:Keratosis, Actinic / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D058866:Osteoporotic Fractures / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000150:complications* / Q000453:epidemiology; D014466:Ultraviolet Rays
chemical_list: D015415:Biomarkers
keywords: Actinic lesions; Biomarker; Osteoporotic hip fractures; Risk factors