title: T-cell/Natural killer-cell neoplasms presenting as leukemia- Case series from single tertiary care center.
abstract: BACKGROUND
  Mature T/ NK-cell neoplasms are a rare group of disorders and their presentation as leukemia is even rarer. Most of the previous studies have focused on mature B-cell lineage leukemias and there is a paucity of data on mature T/NK-cell lineage leukemias. We, therefore, planned this study to analyze their spectrum, frequency, morphology and immunophenotypic features.
  
  
  METHODS
  All cases of lymphomas presenting as leukemia over a period of two and a half years were evaluated. Detailed analysis of cases with T/NK-cell lineage was done for their clinical, hematological and immunophenotypic features.
  
  
  RESULTS
  A total of 262 cases of mature lymphoid neoplasms presented as leukemia during the study period. Of whom, only 8 (3.1%) cases were of T /NK-cell lineage and the remaining (96.9%) were of B-cell lineage. Of 8 cases, 4 (50%) had T-prolymphocytic leukemia, 2 (25%) had chronic lymphoproliferative disorder- natural killer cell and 1 (12.5%) case of each T-large granular lymphocytic leukemia and hepatosplenic γ/δ T-NHL.
  
  
  CONCLUSIONS
  T/NK-cell leukemias are rare. Along with clinical and morphological features, pattern of immunophenotypic markers is vital for their diagnosis and subcategorization.
authors.affiliation: Assistant Professor, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Shano
authors.initials: S
authors.lastname: Naseem
authors.affiliation: Senior Resident, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Maninderbir
authors.initials: M
authors.lastname: Kaur
authors.affiliation: Assistant Professor, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Manupdesh Singh
authors.initials: MS
authors.lastname: Sachdeva
authors.affiliation: Associate Professor, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.affiliation: Professor, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Reena
authors.initials: R
authors.lastname: Das
authors.affiliation: Professor and Head, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Neelam
authors.initials: N
authors.lastname: Varma
authors.affiliation: Professor and Head, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Subhash
authors.initials: S
authors.lastname: Varma
keywords: Immunophenotyping; Morphology; NK-lineage leukemia; T-lineage leukemia