title: The effect of oxytocin on osseointegration of titanium implant in ovariectomized rats.
abstract: Oxytocin (OT) was reported to control differentiation of human mesenchymal stem cells and reverse osteoporosis (OP). This study investigated the effect of systematical treatment of OT on implant osseointegration in ovariectomized (OVX) rats.
  
  
  
  Twenty female rats received bilateral ovariectomy. Twelve weeks later, all animals were randomly assigned to control or experimental group. Each rat received two implants at the distal femoral metaphysis. From the first postoperative day, rats in experiment group received subcutaneous injection of OT (1 mg/kg · d), while animals in control group received vehicle. Twelve weeks after implantation, specimens containing implants were harvested and evaluated by histology, micro-CT, and push-out test. Tibiae were also harvested to evaluate the effect of OT on intact bone tissue of OVX rats.
  
  
  
  Compared with control, OT treatment increased the relative bone volume surrounding the implant by 2.2 times, the percent implant osseointegration by 0.62 times, and the maximum push-out force by 2.25 times. Increased bone mass was also observed in histological sections of distal femur with implant and intact bone tissue of the proximal tibiae.
  
  
  
  Systemic administration of OT promoted peri-implant bone healing and osseointegration of titanium implant and recovered the negative effects of OP in undisturbed bone tissue partially.
authors.affiliation: a Department of Oral and Maxillofacial Surgery , People's Hospital of Zhengzhou University , Zhengzhou , China.
authors.forename: Maiquan
authors.initials: M
authors.lastname: Wang
authors.affiliation: b State Key Laboratory of Oral Diseases , West China Hospital of Stomatology, Sichuan University , Chengdu , China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Lan
authors.affiliation: b State Key Laboratory of Oral Diseases , West China Hospital of Stomatology, Sichuan University , Chengdu , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: b State Key Laboratory of Oral Diseases , West China Hospital of Stomatology, Sichuan University , Chengdu , China.
authors.forename: Jiqing
authors.initials: J
authors.lastname: Li
authors.affiliation: b State Key Laboratory of Oral Diseases , West China Hospital of Stomatology, Sichuan University , Chengdu , China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D005260:Female; D021621:Imaging, Three-Dimensional; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects*; D010052:Ovariectomy; D010121:Oxytocin / Q000494:pharmacology*; D019736:Prostheses and Implants; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects; D014025:Titanium / Q000494:pharmacology*; D055114:X-Ray Microtomography
chemical_list: D010121:Oxytocin; D014025:Titanium
keywords: Implant; osseointegration; osteoporosis; oxytocin; rat