title: The role of metabolic state and obestatin in control of chicken ovarian hormone release.
abstract: The aim of the present study was to examine the role and interrelationships between calorie restriction and obestatin in the control of hormone release by chicken ovarian tissue. For this purpose, we compared the release of progesterone (P), testosteron (T), estradiol (E), and arginine-vasotocin (AVT) by ovarian fragments isolated from chicken subjected and not subjested to food restriction, as well as the response of these ovarian fragments to obestatin additions.It was observed that food restriction promoted release of P, reduced output of T, but did not affect basal E and AVT release. Obestatin addition reduced E, promoted AVT, and did not alter P and T release by ovarian tissue isolated from ad libitum fed chicken. In ovarian fragments of fasted hens it reduced E, promoted T, and did not influence P and AVT release.The present observations demonstrate (1) that obestatin can directly control the release of avian ovarian hormones - regulators of reproduction, (2) that metabolic state can control the release of these hormones, and (3) metabolic state can alter the response of ovarian hormones to obestatin.
authors.affiliation: Dept. Zoology and Anthropology, Constantine the Philosopher University, 949 74 Nitra, Slovakia Dept. Genetics and Reproduction, Research Institute of Animal Production, 949 59 Lužianky asirotkin@ukf.sk.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Sirotkin
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Abdel Halim
authors.initials: AH
authors.lastname: Harrath
authors.affiliation: Dept. Functional Genomics & Bioregulation, Friedrich Loeffler Institute, Mariensee, Neustadt, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Grossmann
mesh_terms: D000818:Animals; D031204:Caloric Restriction / Q000662:veterinary; D002645:Chickens / Q000378:metabolism / Q000502:physiology*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D054439:Ghrelin / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D011374:Progesterone / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism; D014668:Vasotocin / Q000378:metabolism
chemical_list: D054439:Ghrelin; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D014668:Vasotocin
keywords: chicken; feeding; ghrelin; leptin; obestatin