title: Properties of substances inhibiting aggregation of oxidized GAPDH: Data on the interaction with the enzyme and the impact on its intracellular content.
abstract: This data is related to our paper "Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress" (Lazarev et al. [1]) where we explore therapeutic properties of small molecules preventing GAPDH aggregation in cell and rat models of oxidative stress. The present article demonstrates a few of additional properties of the chemicals shown to block GAPDH aggregation such as calculated site for targeting the enzyme, effects on GAPDH glycolytic activity, influence on GAPDH intracellular level and anti-aggregate activity of pure polyglutamine exemplifying a denatured protein.
authors.affiliation: Institute of Cytology Russian Academy of Sciences, 194064 St. Petersburg, Russia.
authors.forename: Vladimir F
authors.initials: VF
authors.lastname: Lazarev
authors.affiliation: Institute of Cytology Russian Academy of Sciences, 194064 St. Petersburg, Russia.
authors.forename: Alina D
authors.initials: AD
authors.lastname: Nikotina
authors.affiliation: Belozersky Institute of Physico-Chemical Biology of Moscow State University, 119992 Moscow, Russia.
authors.forename: Pavel I
authors.initials: PI
authors.lastname: Semenyuk
authors.affiliation: Belozersky Institute of Physico-Chemical Biology of Moscow State University, 119992 Moscow, Russia.
authors.forename: Diana B
authors.initials: DB
authors.lastname: Evstafyeva
authors.affiliation: Institute of Cytology Russian Academy of Sciences, 194064 St. Petersburg, Russia.
authors.forename: Elena R
authors.initials: ER
authors.lastname: Mikhaylova
authors.affiliation: Belozersky Institute of Physico-Chemical Biology of Moscow State University, 119992 Moscow, Russia.
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Muronetz
authors.affiliation: Institute of Cytology Russian Academy of Sciences, 194064 St. Petersburg, Russia.
authors.forename: Maxim A
authors.initials: MA
authors.lastname: Shevtsov
authors.affiliation: Institute of Cytology Russian Academy of Sciences, 194064 St. Petersburg, Russia.
authors.forename: Anastasia V
authors.initials: AV
authors.lastname: Tolkacheva
authors.affiliation: Institute of Macromolecular Compounds Russian Academy of Sciences, 199004 St. Petersburg, Russia.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Dobrodumov
authors.affiliation: Komarov Botanical Institute Russian Academy of Sciences, 197376 St. Petersburg, Russia.
authors.forename: Alexey L
authors.initials: AL
authors.lastname: Shavarda
authors.affiliation: Institute of Cytology Russian Academy of Sciences, 194064 St. Petersburg, Russia.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Guzhova
authors.affiliation: Institute of Cytology Russian Academy of Sciences, 194064 St. Petersburg, Russia.
authors.forename: Boris A
authors.initials: BA
authors.lastname: Margulis