title: Metabolomic application in toxicity evaluation and toxicological biomarker identification of natural product.
abstract: Natural product plays a vital role in disease prevention and treatment since the appearance of civilization, but the toxicity severely hinders its wide use. In order to avoid toxic effect as far as possible and use natural product safely, more comprehensive understandings of toxicity are urgently required. Since the metabolome represents the physiological or pathological status of organisms, metabolomics-based toxicology is of significance to observe potential injury before toxins have caused physiological or pathological damages. Metabolomics-based toxicology can evaluate toxicity and identify toxicological biomarker of natural product, which is helpful to guide clinical medication and reduce adverse drug reactions. In the past decades, dozens of metabolomic researches have been implemented on toxicity evaluation, toxicological biomarker identification and potential mechanism exploration of nephrotoxicity, hepatotoxicity, cardiotoxicity and central nervous system toxicity induced by pure compounds, extracts and compound prescriptions. In this paper, metabolomic technology, sample preparation, data process and analysis, and metabolomics-based toxicological research of natural product are reviewed, and finally, the potential problems and further perspectives in toxicological metabolomic investigations of natural product are discussed.
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
authors.forename: Dan-Qian
authors.initials: DQ
authors.lastname: Chen
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Tang
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Miao
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address: zyy@nwu.edu.cn.
authors.forename: Ying-Yong
authors.initials: YY
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001688:Biological Products / Q000378:metabolism / Q000633:toxicity*; D002853:Chromatography, Liquid / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D018675:Toxicity Tests / Q000379:methods
chemical_list: D001688:Biological Products
keywords: Biomarker; Liquid chromatography; Metabolomics; Natural product; Toxicity