title: Oral administration of Aloe vera gel powder prevents UVB-induced decrease in skin elasticity via suppression of overexpression of MMPs in hairless mice.
abstract: This study reports the effects of oral Aloe vera gel powder (AVGP) containing Aloe sterols on skin elasticity and the extracellular matrix in ultraviolet B (UVB)-irradiated hairless mice. Ten-week-old hairless mice were fed diets containing 0.3% AVGP for 8 weeks and irradiated UVB for 6 weeks. Mice treated with AVGP showed significant prevention of the UVB-induced decrease in skin elasticity. To investigate the mechanism underlying this suppression of skin elasticity loss, we measured the expression of matrix metalloproteinase (MMP)-2, -9, and -13. AVGP prevented both the UVB-induced increases in MMPs expressions. Moreover, we investigated hyaluronic acid (HA) content of mice dorsal skin and gene expression of HA synthase-2 (Has2). In the results, AVGP oral administration prevented UVB-induced decreasing in skin HA content and Has2 expression and attenuates the UVB-induced decrease in serum adiponectin, which promotes Has2 expression. These results suggested that AVGP has the ability to prevent the skin photoaging.
authors.affiliation: a Functional Food Ingredients Department, Food Ingredients & Technology Institute , Morinaga Milk Industry Co. Ltd. , Zama , Japan.
authors.forename: Marie
authors.initials: M
authors.lastname: Saito
authors.affiliation: a Functional Food Ingredients Department, Food Ingredients & Technology Institute , Morinaga Milk Industry Co. Ltd. , Zama , Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: a Functional Food Ingredients Department, Food Ingredients & Technology Institute , Morinaga Milk Industry Co. Ltd. , Zama , Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Misawa
authors.affiliation: a Functional Food Ingredients Department, Food Ingredients & Technology Institute , Morinaga Milk Industry Co. Ltd. , Zama , Japan.
authors.forename: Ruiquing
authors.initials: R
authors.lastname: Yao
authors.affiliation: a Functional Food Ingredients Department, Food Ingredients & Technology Institute , Morinaga Milk Industry Co. Ltd. , Zama , Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nabeshima
authors.affiliation: a Functional Food Ingredients Department, Food Ingredients & Technology Institute , Morinaga Milk Industry Co. Ltd. , Zama , Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: a Functional Food Ingredients Department, Food Ingredients & Technology Institute , Morinaga Milk Industry Co. Ltd. , Zama , Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Abe
authors.affiliation: b Department of Dermatology , Wakayama Medical University , Wakayama , Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: b Department of Dermatology , Wakayama Medical University , Wakayama , Japan.
authors.forename: Fukumi
authors.initials: F
authors.lastname: Furukawa
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics; D000284:Administration, Oral; D000504:Aloe / Q000737:chemistry*; D000818:Animals; D004548:Elasticity / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005260:Female; D005782:Gels / Q000737:chemistry / Q000494:pharmacology; D005786:Gene Expression Regulation; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid / Q000096:biosynthesis; D053509:Matrix Metalloproteinase 13 / Q000235:genetics / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000235:genetics* / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008812:Mice, Hairless; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011208:Powders; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D052242:Adiponectin; C499919:Adipoq protein, mouse; D005782:Gels; D010936:Plant Extracts; D011208:Powders; D006820:Hyaluronic Acid; D014453:Glucuronosyltransferase; C491099:Has2 protein, mouse; D000076002:Hyaluronan Synthases; D053509:Matrix Metalloproteinase 13; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: Aloe vera; MMP; UVB; extracellular matrix; skin elasticity