title: Polymorphism 2184A/G in the AGER gene is not associated with diabetic retinopathy in Han Chinese patients with type 2 diabetes.
abstract: OBJECTIVE
  To assess the association between the 2184A/G polymorphism in the advanced glycosylation end product-specific receptor (AGER) gene and the susceptibility to diabetic retinopathy (DR) in Han Chinese patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  This cross-sectional genotyping study included patients with T2DM with and without DR. Genotype and allele frequencies of the 2184A/G polymorphism were detected using polymerase chain reaction-restriction fragment-length polymorphism analysis.
  
  
  RESULTS
  This study included 943 patients with T2DM (285 with DR [DR group] and 658 without DR [NDR group]). There were no significant differences in age, sex, body mass index, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, diastolic blood pressure, glycosylated haemoglobin, fasting blood glucose, postprandial 2-hour blood glucose, and triglycerides between the two groups. The duration of T2DM and systolic blood pressure were significantly increased in the DR group compared with the NDR group. No significant differences were found in allele (A and G) and genotype (AA, AG and GG) frequencies of the 2184A/G polymorphism between the two groups.
  
  
  CONCLUSIONS
  The 2184A/G polymorphism in the AGER gene is not associated with DR in Han Chinese patients with T2DM.
authors.affiliation: Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China Department of Endocrinology and Metabolism, First People's Hospital of Xinxiang City, Xinxiang, Henan Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Medical Biology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
authors.affiliation: Department of Endocrinology and Metabolism, Third Affiliated Hospital of Ganzhou Medical College, Ganzhou, Jiangxi Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Yue
authors.affiliation: Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Ling-Yan
authors.initials: LY
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Jun-Ren
authors.initials: JR
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China xujx1027@sina.com.
authors.forename: Ji-Xiong
authors.initials: JX
authors.lastname: Xu
mesh_terms: D044466:Asian People / Q000235:genetics*; D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics*
chemical_list: D000067759:Receptor for Advanced Glycation End Products
keywords: 2184A/G; Han Chinese; Receptor for advanced glycation end-products (RAGE); diabetic retinopathy; gene polymorphism; type 2 diabetes mellitus