title: Choroidal metastasis as a presenting manifestation of a lung adenocarcinoma with response to afatinib.
abstract: METHODS
  We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up.
  
  
  CONCLUSIONS
  Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation.
authors.affiliation: Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: Mig.contreras@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Contreras-Díaz
authors.affiliation: Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: A
authors.initials: A
authors.lastname: Medina-Tapia
authors.affiliation: Unidad de Gestión Clínica de Oncología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: G
authors.initials: G
authors.lastname: Martínez-Bernal
authors.affiliation: Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: T
authors.initials: T
authors.lastname: Rueda-Rueda
authors.affiliation: Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: F
authors.initials: F
authors.lastname: López-Herrero
authors.affiliation: Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: F E
authors.initials: FE
authors.lastname: Molina-Socola
authors.affiliation: Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez-Vicente
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology / Q000556:secondary*; D000077192:Adenocarcinoma of Lung; D000077716:Afatinib; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology / Q000556:secondary*; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology / Q000556:secondary*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011799:Quinazolines / Q000494:pharmacology / Q000627:therapeutic use*; D012074:Remission Induction; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000077716:Afatinib; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: Adenocarcinoma de pulmón; Afatinib; Choroidal metastasis; Choroidal tumours; EFGR mutation; Lung adenocarcinoma; Metástasis coroidea; Mutación EFGR; Tumores coroideos