title: Clinical and morphological aspects of adenocarcinomas of the intestinal type in the inner nose: a retrospective multicenter analysis.
abstract: Clinical and histological parameters from 117 patients with wood dust-related sinonasal adenocarcinomas of intestinal type (ITAC) were analyzed and correlated with a follow-up period of 5 years at least. The rate of survival for 5 years was 53.1 % and for 10 years 30.2 %. Only 33 patients were free of disease. 74.2 % of patients with recurrences died in relation to ITAC. As expected, tumors of T4-category had the worst prognosis. The mucus content of a tumor was the most important histological parameter. Endonasal methods of surgery had no more positive survival rates after 5 years. An effect of radiotherapy has to be in discussion. The high incidence of tumor recurrences requires control examinations consistently.
authors.affiliation: Institute of Pathology, Academic Hospital Braunschweig, Braunschweig, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Donhuijsen
authors.affiliation: Institute of Pathology, Academic Hospital Braunschweig, Braunschweig, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Kollecker
authors.affiliation: Institute of Special Pharmacotherapy, Helios-Clinic of Oncology, Duisburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Petersen
authors.affiliation: Institute of Pathology, Academic Hospital Braunschweig, Braunschweig, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Gaßler
authors.affiliation: Professional Trade Association for Wood and Metal, Munich, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Wolf
authors.affiliation: ENT-Clinic, Academic Hospital Braunschweig, Braunschweig, Germany. hageschroeder@gmail.com.
authors.forename: H-G
authors.initials: HG
authors.lastname: Schroeder
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004391:Dust; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009784:Occupational Diseases / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D014934:Wood / Q000633:toxicity*
chemical_list: D004391:Dust
keywords: Follow-up; Prognostic factor; Radiotherapy; Sinonasal adenocarcinoma; Wood dust