title: [ON THE ORIGIN OF HYPERVIRULENCE OF THE CAUSATIVE AGENT OF PLAGUE].
abstract: The attempt to combine Yersinia pseudotuberculosis and Yersinia pestis into one species has been unsupported by microbiologists due to the specific features of the epidemiology and clinical presentations of their induced diseases and to basic differences in their virulence. Pseudotuberculosis is predominantly a relatively mild human intestinal infection transmitted through contaminated food and plague is an acute generalized disease with high mortality, which is most frequently transmitted by the bites of infected fleas. Y. pestis hypervirulence, the ability of single bacteria to ensure the development of predagonal bacteriemia in rodents, which is sufficient to contaminate the fleas, is one of the main events during pathogen adaptation to a new ecological niche. By analyzing the data of molecular typing of the representative kits of naturally occurring Y. pestis isolates, the authois consider the issues of formation of intraspecies groups with universal hypervirulence, as well as biovars that are highly virulent only to their major host. A strategy for searching for selective virulence factors, the potential molecular targets for vaccination and etiotropic treatment of plague, is discussed.
authors.forename: N V
authors.initials: NV
authors.lastname: Anisimov
authors.forename: A A
authors.initials: AA
authors.lastname: Kislichkina
authors.forename: M E
authors.initials: ME
authors.lastname: Platonov
authors.forename: V V
authors.initials: VV
authors.lastname: Evseeva
authors.forename: L A
authors.initials: LA
authors.lastname: Kadnikova
authors.forename: N A
authors.initials: NA
authors.lastname: Lipatnikova
authors.forename: A G
authors.initials: AG
authors.lastname: Bogun
authors.forename: S V
authors.initials: SV
authors.lastname: Dentovskaya
authors.forename: A P
authors.initials: AP
authors.lastname: Anisimov
mesh_terms: D000818:Animals; D005075:Biological Evolution; D015870:Gene Expression; D006801:Humans; D010802:Phylogeny; D010930:Plague / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission / Q000662:veterinary*; D012377:Rodentia / Q000382:microbiology; D012426:Russia / Q000453:epidemiology; D005423:Siphonaptera / Q000382:microbiology*; D013045:Species Specificity; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism; D015010:Yersinia pestis / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D015011:Yersinia pseudotuberculosis / Q000145:classification / Q000235:genetics; D015012:Yersinia pseudotuberculosis Infections / Q000382:microbiology; D015047:Zoonoses / Q000453:epidemiology / Q000382:microbiology
chemical_list: D037521:Virulence Factors