title: The Correlation of Serums CCL11, CCL17, CCL26, and CCL27 and Disease Severity in Patients with Urticaria.
abstract: BACKGROUND
  Chemokines may be involved in the pathogenesis of urticaria, but their correlation with disease severity as well as eruption type is unclear.
  
  
  OBJECTIVE
  The aim of this study was to explore the expression of chemokines in patients with urticaria. The association between disease severity and levels of chemokines was analysed.
  
  
  METHODS
  Serums CCL11, CCL17, CCL26, and CCL27, D-dimer, C-reactive protein, and total IgE were measured in 51 patients with urticaria and in 25 healthy control subjects.
  
  
  RESULTS
  Serums CCL11, CCL17, CCL26, and CCL27 were significantly higher in patients with urticaria than in the healthy controls (P < 0.05). Serum CCL27 strongly correlated with urticarial disease severity. Serums CCL17, CCL26, and CCL27 significantly correlated with D-dimer, while innercorrelations were noted among the chemokines.
  
  
  CONCLUSIONS
  Our findings reveal that chemokines participate in the pathogenesis of urticaria. Further study in larger cohort is needed to testify whether they could be the biomarkers for predicting the severity of urticaria.
authors.affiliation: Department of Dermatology, The Affiliated Nanfang Hospital of Southern Medical University, Guangzhou 510515, China; Department of Dermatology, The First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China.
authors.forename: Tao
authors.identifier: 0000-0002-9580-0451
authors.initials: T
authors.lastname: Lu
authors.affiliation: Cell Biology and Genetics Department, Shantou University Medical College, Shantou 515041, China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Jiao
authors.affiliation: Cell Biology and Genetics Department, Shantou University Medical College, Shantou 515041, China.
authors.forename: Mengya
authors.initials: M
authors.lastname: Si
authors.affiliation: Cell Biology and Genetics Department, Shantou University Medical College, Shantou 515041, China.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: Department of Dermatology, The First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Zou
authors.affiliation: Department of Dermatology, The First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, The Affiliated Nanfang Hospital of Southern Medical University, Guangzhou 510515, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Zeng
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D054413:Chemokine CCL11 / Q000097:blood*; D054414:Chemokine CCL17 / Q000097:blood*; D000075906:Chemokine CCL26; D054425:Chemokine CCL27 / Q000097:blood*; D019742:Chemokines, CC / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014581:Urticaria / Q000276:immunology* / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; C515456:CCL11 protein, human; C106230:CCL17 protein, human; C120429:CCL26 protein, human; C492276:CCL27 protein, human; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D000075906:Chemokine CCL26; D054425:Chemokine CCL27; D019742:Chemokines, CC