title: The Emerging Role of PI3K Inhibitors in the Treatment of Hematological Malignancies: Preclinical Data and Clinical Progress to Date.
abstract: The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have broadened our understanding of PI3K inhibition. Several PI3K inhibitors are currently in advanced stages of clinical development. Idelalisib is the first agent of this new substance class to be approved in chronic lymphocytic leukemia and follicular lymphoma. Other agents specifically target different PI3K isoforms and show promising clinical efficacy.
authors.affiliation: Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University (LMU), Marchioninistraße 15, Munich, 81377, Germany.
authors.forename: Till
authors.initials: T
authors.lastname: Seiler
authors.affiliation: Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University (LMU), Marchioninistraße 15, Munich, 81377, Germany.
authors.forename: Grit
authors.initials: G
authors.lastname: Hutter
authors.affiliation: Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University (LMU), Marchioninistraße 15, Munich, 81377, Germany. Martin.Dreyling@med.uni-muenchen.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Dreyling
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors