title: Ancillary therapy of intranasal T-LysYal® for patients with allergic, non-allergic, and mixed rhinitis.
abstract: Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction. Non-allergic rhinitis (NAR) is characterized by a non-IgE-mediated pathogenesis. Frequently, patients have the two disorders associated: such as mixed rhinitis (MR). Hyaluronic acid (HA) is a fundamental component of the human connective tissue. HA may exert anti-inflammatory and immune-modulating activities. Recently, an intranasal HA formulation was proposed: a supramolecular system containing lysine hyaluronate, thymine and sodium chloride (T-LysYal®). This randomized study investigated whether intranasal T-LysYal® (rinoLysYal®, Farmigea, Italy) was able to reduce symptom severity, endoscopic features, and nasal cytology in 89 patients (48 males and 41 females, mean age 36.3±7.1 years) with AR, NAR, and MR. Patients were treated with intranasal T-LysYal® or isotonic saline solution as adjunctive therapy to nasal corticosteroid and oral antihistamine for 4 weeks. Patients were visited at baseline, after treatment and after 4-week follow-up. Intranasal T-LysYal® treatment significantly reduced the quote of patients with symptoms, endoscopic features, and inflammatory cells. In conclusion, the present study demonstrates that intranasal T-LysYal® is able, as ancillary therapy, to significantly improve patients with AR, NAR, and MR, and its effect is long lasting.
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gelardi
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Taliente
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Fiorella
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Quaranta
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ciancio
authors.affiliation: U.O.C. di Otorinolaringoiatria - Ospedale Di Venere, Carbonara Di Bari (BA), Italy.
authors.forename: C
authors.initials: C
authors.lastname: Russo
authors.affiliation: Division of Otolaryngology, Pinerolo and Rivoli Hospitals, ASL TO3, Pinerolo, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mola
authors.affiliation: Rhinology and Immuno-Allergy Unit, Sense Organs Department, Otolaryngology Section, Umberto I General Hospital, La Sapienza University, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ciofalo
authors.affiliation: Rhinology and Immuno-Allergy Unit, Sense Organs Department, Otolaryngology Section, Umberto I General Hospital, La Sapienza University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Zambetti
authors.affiliation: AIAS - Afragola (NA), Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caruso Armone
authors.affiliation: Department of Neuroscience, Reproductive and Dentistry Science, ENT Unit; Federico II University, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cantone
authors.affiliation: Department of Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.) - Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ciprandi
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008239:Lysine / Q000008:administration & dosage* / Q000627:therapeutic use*; D008297:Male; D009504:Neutrophils / Q000473:pathology; D012220:Rhinitis / Q000188:drug therapy*; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000627:therapeutic use*; D013941:Thymine / Q000008:administration & dosage* / Q000627:therapeutic use*; D014420:Turbinates / Q000473:pathology
chemical_list: C000608691:T-LysYal; D012965:Sodium Chloride; D008239:Lysine; D013941:Thymine