title: Evaluation of effectiveness of hyaluronic acid in combination with bioresorbable membrane (poly lactic acid-poly glycolic acid) for the treatment of infrabony defects in humans: A clinical and radiographic study.
abstract: BACKGROUND
  The combination of biomaterials, bone graft substitutes along with guided tissue regeneration (GTR) has been shown to be an effective modality of periodontal regenerative therapy for infrabony defects. Therefore, the present randomized controlled clinical study was undertaken to evaluate the effectiveness of hyaluronic acid (HA) in combination with bioresorbable membrane for the treatment of human infrabony defects.
  
  
  METHODS
  Twenty four infrabony defects in 20 systemically healthy patients were randomly assigned to test (HA in combination with bioresorbable membrane) and control (bioresorbable membrane alone) treatment groups. Probing pocket depth (PPD), relative attachment level, and relative gingival margin level were measured with a computerized Florida disc probe at baseline and at 6 months follow-up. Radiographic measurements were also evaluated at baseline and at 6 months of postsurgery.
  
  
  RESULTS
  At 6 months, the mean reduction in PPD in test group and control group was 4.52 mm and 2.97 mm, respectively. Significantly higher clinical attachment level with a gain of 2.20 mm was found in the test group as compared to control group. In addition, statistically significant greater reduction of radiographic defect depth was observed in the test group.
  
  
  CONCLUSIONS
  Regenerative approach using hyaloss in combination with GTR for the treatment of human infrabony defects resulted in a significant added benefit in terms of CAL gains, PPD reductions and radiographic defect fill, as well as LBG, compared to the GTR alone.
authors.affiliation: Department of Periodontology, R R Dental College and Hospital, Umarda District, Udaipur, Rajasthan, India.
authors.forename: Bhumika
authors.initials: B
authors.lastname: Sehdev
authors.affiliation: Department of Periodontology and Implantology, Sharad Pawar Dental College, Wardha (Affiliated to Datta Meghe Institute of Medical Sciences, Nagpur), Maharashtra, India.
authors.forename: Manohar Laxmanrao
authors.initials: ML
authors.lastname: Bhongade
authors.affiliation: Department of Preventive Dentistry, College of Dentistry, (Affiliated to Al Jouf University), Al Jouf, KSA.
authors.forename: Kiran Kumar
authors.initials: KK
authors.lastname: Ganji
keywords: Guided tissue regeneration; hyaluronic acid; infrabony defects