title: A Novel Prioritization Method in Identifying Recurrent Venous Thromboembolism-Related Genes.
abstract: Identifying the genes involved in venous thromboembolism (VTE) recurrence is important not only for understanding the pathogenesis but also for discovering the therapeutic targets. We proposed a novel prioritization method called Function-Interaction-Pearson (FIP) by creating gene-disease similarity scores to prioritize candidate genes underling VTE. The scores were calculated by integrating and optimizing three types of resources including gene expression, gene ontology and protein-protein interaction. As a result, 124 out of top 200 prioritized candidate genes had been confirmed in literature, among which there were 34 antithrombotic drug targets. Compared with two well-known gene prioritization tools Endeavour and ToppNet, FIP was shown to have better performance. The approach provides a valuable alternative for drug targets discovery and disease therapy.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Wan
authors.initials: W
authors.lastname: Li
authors.affiliation: National Microbology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
authors.forename: Binhua
authors.initials: B
authors.lastname: Liang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Xie
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Binbin
authors.initials: B
authors.lastname: Chen
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Yuehan
authors.initials: Y
authors.lastname: He
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Junjie
authors.initials: J
authors.lastname: Lv
authors.affiliation: Institute of Opto-electronics, Harbin Institute of Technology, Harbin, Hei Longjiang Province, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: He
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, China, Postal code: 150081.
authors.forename: Lina
authors.initials: L
authors.lastname: Chen
mesh_terms: D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D012008:Recurrence; D054556:Venous Thromboembolism / Q000235:genetics*