title: Maximal exercise does not increase ventilation heterogeneity in healthy trained adults.
abstract: The effect of exercise on ventilation heterogeneity has not been investigated. We hypothesized that a maximal exercise bout would increase ventilation heterogeneity. We also hypothesized that increased ventilation heterogeneity would be associated with exercise-induced arterial hypoxemia (EIAH). Healthy trained adult males were prospectively assessed for ventilation heterogeneity using lung clearance index (LCI), Scond, and Sacinat baseline, postexercise and at recovery, using the multiple breath nitrogen washout technique. The maximal exercise bout consisted of a maximal, incremental cardiopulmonary exercise test at 25 watt increments. Eighteen subjects were recruited with mean ± SDage of 35 ± 9 years. There were no significant changes inLCI, Scond, or Sacinfollowing exercise or at recovery. While there was an overall reduction in SpO2with exercise (99.3 ± 1 to 93.7 ± 3%,P < 0.0001), the reduction in SpO2was not associated with changes inLCI, Scondor Sacin Ventilation heterogeneity is not increased following a maximal exercise bout in healthy trained adults. Furthermore,EIAHis not associated with changes in ventilation heterogeneity in healthy trained adults.
authors.affiliation: Department of Medicine, Monash University, Melbourne, Australia Allergy, Immunology & Respiratory Medicine, The Alfred, Melbourne, Australia Department of Respiratory Medicine, Fiona Stanley Hospital, Perth, Australia jeremy.wrobel@health.wa.gov.au.
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Wrobel
authors.affiliation: Allergy, Immunology & Respiratory Medicine, The Alfred, Melbourne, Australia.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ellis
authors.affiliation: Department of Medicine, Monash University, Melbourne, Australia Allergy, Immunology & Respiratory Medicine, The Alfred, Melbourne, Australia.
authors.forename: Kirk
authors.initials: K
authors.lastname: Kee
authors.affiliation: Allergy, Immunology & Respiratory Medicine, The Alfred, Melbourne, Australia.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Stuart-Andrews
authors.affiliation: Department of Medicine, Monash University, Melbourne, Australia Allergy, Immunology & Respiratory Medicine, The Alfred, Melbourne, Australia.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Thompson
mesh_terms: D000328:Adult; D001642:Bicycling; D015444:Exercise; D005080:Exercise Test; D064368:Healthy Volunteers; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012123:Pulmonary Ventilation; D020127:Recovery of Function; D013997:Time Factors
keywords: Cardiopulmonary exercise test; hypoxemia; lung clearance index; multiple breath nitrogen washout; ventilation inhomogeneity