title: The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
abstract: Four possible isomers of essramycin, a natural product from a marine Streptomyces species isolated from the Egyptian Mediterranean coast, were synthesized. The structures for the isomers were assigned unequivocally by (1)H NMR, (13)C NMR, high-resolution mass spectrometry, and X-ray crystal structure determinations. Notwithstanding the earlier report of broad-spectrum antibacterial activity for the natural product, none of the four isomers exhibited any such activity.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
authors.forename: Dusan
authors.initials: D
authors.lastname: Hesek
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
authors.forename: Mijoon
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
authors.forename: Elena
authors.initials: E
authors.lastname: Lastochkin
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
authors.forename: Allen G
authors.initials: AG
authors.lastname: Oliver
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
authors.forename: Mayland
authors.initials: M
authors.lastname: Chang
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Mobashery
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D004534:Egypt; D008386:Marine Biology; D008522:Mediterranean Sea; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011744:Pyrimidinones / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D011744:Pyrimidinones; D014230:Triazoles; C532326:essramycin