title: Understanding the CREB1-miRNA feedback loop in human malignancies.
abstract: cAMP response element binding protein 1 (CREB1, CREB) is a key transcription factor that mediates transcriptional responses to a variety of growth factors and stress signals. CREB1 has been shown to play a critical role in development and progression of tumors. MicroRNAs (miRNAs) are a class of non-coding RNAs. They post-transcriptionally regulate gene expression through pairing with the 3'-UTR of their target mRNAs and thus regulate initiation and progression of various types of human cancers. Recent studies have demonstrated that a number of miRNAs can be transcriptionally regulated by CREB1. Interestingly, CREB1 expression can also be modulated by miRNAs, thus forming a feedback loop. This review outlines the functional roles of CREB1, miRNA, and their interactions in human malignancies. This will help to define a relationship between CREB1 and miRNA in human cancer and develop novel therapeutic strategies.
authors.affiliation: Department of Pathology, School of Medicine, Shandong University, Jinan, 250012, People's Republic of China.|Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, 250012, People's Republic of China.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Wang
authors.affiliation: Department of Pathology, School of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, 250012, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Ma
authors.affiliation: Department of Pathology, School of Medicine, Shandong University, Jinan, 250012, People's Republic of China. gaopeng@sdu.edu.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D020413:3' Untranslated Regions; C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D035683:MicroRNAs
keywords: CREB1; Cancer; Feedback loop; Transcription factor; miRNA