title: Synthesis of a poly(ethylene glycol) galloyl sensitizer tip for an 'all-in-one' photodynamic device.
abstract: This paper describes the synthesis of a specialized silica tip for an optical fiber device capable of delivering all components necessary for photodynamic therapy. Oxygen, light and a cleavable tripolyethylene glycol (PEG)-galloyl pheophorbide sensitizer are simultaneously delivered by the silica tip, where the tip was synthesized in six steps. A comparison of synthetic steps to reach PEGylated sensitizers bound to fluorinated silica and a previously reported Teflon/polyvinyl alcohol (PVA) nanocomposite ( Ghosh, G. et al. J. Phys. Chem. B 2015, 119, 4155- 4164) was made. The hydrolytic stability of the attached PEGs and the extent to which the PEG groups enhance solubility will also be discussed. The new triPEG-galloyl sensitizer has the potential for use in intraoperative pointsource photodynamic therapy which aims for precision treatment of residual disease. Schematic of the synthesis of a photoactive silica surface. It is composed of fluorinated silica connected to a photo-releasable sensitizer with short-chain PEGs.
authors.affiliation: Department of Chemistry, Brooklyn College, 2900 Bedford Avenue, Brooklyn, New York, 11210, United States.|Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York, 10016, United States.
authors.forename: Ashwini A
authors.initials: AA
authors.lastname: Ghogare
authors.affiliation: Department of Chemistry, Brooklyn College, 2900 Bedford Avenue, Brooklyn, New York, 11210, United States.|Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York, 10016, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Greer
mesh_terms: D006801:Humans; D008027:Light; D053761:Nanocomposites; D010778:Photochemotherapy / Q000295:instrumentation*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012822:Silicon Dioxide
chemical_list: D011092:Polyethylene Glycols; D012822:Silicon Dioxide
keywords: photo-cleavable sensitizer; pointsource PDT; silica surface; singlet oxygen