title: FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion.
abstract: Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancer; however, its function in gastric cancer remains unknown. In the current study, we showed that FGF19 is overexpressed in gastric cancer and is associated with depth of invasion, lymph node metastasis, and TNM stage. In addition, in vitro experiments demonstrated that FGF19 is able to enhance migration and invasion abilities of gastric cancer cells. Given its great potency in gastric cancer progression, FGF19 may be an effective target of treatment for advanced gastric cancer patients.
authors.affiliation: Department of Clinical Oncology, The Central Hospital of Taian, Taian, Shandong, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Daqi
authors.initials: D
authors.lastname: Zhao
authors.forename: Ruihua
authors.initials: R
authors.lastname: Tian
authors.forename: Hailong
authors.initials: H
authors.lastname: Shi
authors.forename: Xiangming
authors.initials: X
authors.lastname: Chen
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D002465:Cell Movement; D018450:Disease Progression; D005260:Female; D005346:Fibroblast Growth Factors / Q000502:physiology*; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C117476:FGF19 protein, human; D005346:Fibroblast Growth Factors