title: Induced Bacterial Cross-Resistance toward Host Antimicrobial Peptides: A Worrying Phenomenon.
abstract: Bacterial resistance to conventional antibiotics has reached alarming levels, threatening to return to the pre-antibiotic era. Therefore, the search for new antimicrobial compounds that overcome the resistance phenomenon has become a priority. Antimicrobial peptides (AMPs) appear as one of the most promising antibiotic medicines. However, in recent years several AMP-resistance mechanisms have been described. Moreover, the AMP-resistance phenomenon has become more complex due to its association with cross-resistance toward AMP effectors of the host innate immune system. In this context, the use of AMPs as a therapeutic option could be potentially hazardous, since bacteria could develop resistance toward our innate immune system. Here, we review the findings of major studies that deal with the AMP cross-resistance phenomenon.
authors.affiliation: Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de BrasíliaBrasília, Brazil; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de BrasíliaBrasília, Brazil.
authors.forename: Osmel
authors.initials: O
authors.lastname: Fleitas
authors.affiliation: Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de BrasíliaBrasília, Brazil; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de BrasíliaBrasília, Brazil; Programa de Pós-Graduação em Biotecnologia, S-Inova Biotech,Universidade Católica Dom BoscoCampo Grande, Brazil.
authors.forename: Octávio L
authors.initials: OL
authors.lastname: Franco
keywords: antibiotics; antimicrobial peptides; bacterial infection; cross-resistance