title: Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics.
abstract: Ten years of remarkable progress in understanding the fundamental biochemistry of Alzheimer's disease have been followed by ten years of remarkable and increasing clinical insight into the natural progression of the disorder. The concept of a long, intermediary, prodromal phase between the first appearance of amyloid plaques and tangles and the manifestation of dementia is now well established. The major challenge for the next decade is to chart the many cellular processes that underlie this phase and link the biochemical alterations to the clinical manifestation of Alzheimer's disease. We discuss here how genetics, new cell culture systems, and improved animal models will fuel this work. We anticipate that the resulting novel insights will provide a basis for further drug development for this terrible disease.
authors.affiliation: VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, Leuven 3000, Belgium; email: carlo.salafrigerio@cme.vib-kuleuven.be , bart.destrooper@cme.vib-kuleuven.be.|Center for Human Genetics, KU Leuven, Leuven 3000, Belgium.|Leuven Research Institute for Neuroscience & Disease (LIND), KU Leuven, Leuven 3000, Belgium.
authors.forename: Carlo
authors.initials: C
authors.lastname: Sala Frigerio
authors.affiliation: VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, Leuven 3000, Belgium; email: carlo.salafrigerio@cme.vib-kuleuven.be , bart.destrooper@cme.vib-kuleuven.be.|Center for Human Genetics, KU Leuven, Leuven 3000, Belgium.|Leuven Research Institute for Neuroscience & Disease (LIND), KU Leuven, Leuven 3000, Belgium.|Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
authors.forename: Bart
authors.initials: B
authors.lastname: De Strooper
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D058225:Plaque, Amyloid / Q000378:metabolism*; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins
keywords: amyloid-β; iPSC; preclinical Alzheimer's disease; tau