title: Chemical Constituents of the Aerial Parts of Euphorbia nematocypha.
abstract: Chemical constituents of the dried aerial parts of Euphorbia nematocypha were investigated. A new oleanane triterpenoid, trans, trans-2',4'- hexadienedioicacid-1'-β-amyrin ester (1), together with, β-amyrin (2), β-amyrin acetate (3), betulinic acid (4), ellagic acid (5), oleanolic acid (6), β-sitosterol (7), kaempferol (8), quercetin (9), lupeol (10) and pseudo-taraxasterol (11) were isolated from the methylene chloride extract. Their structures were elucidated on the basis of extensive spectroscopic (1D- & 2D-NMR) and ESI-MS analysis and comparison with data reported in the literature. The new isolated triterpenoid showed moderate cytotoxic activities against HeLa and MCF-7cell lines.
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Jia
authors.forename: Bo
authors.initials: B
authors.lastname: Zuo
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Liao
authors.forename: Lan-Ju
authors.initials: LJ
authors.lastname: Ji
authors.forename: Hong-Fa
authors.initials: HF
authors.lastname: Sun
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives; D035261:Plant Components, Aerial / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C000607054:trans, trans-2',4'- hexadienedioicacid-1'-beta-amyrin ester; D009828:Oleanolic Acid