title: A new Secondary metabolites of the crinoid (Comanthina schlegeli) associated fungus Alternaria brassicae 93.
abstract: Fungus Alternaria brassicae 93 isolated from crinoid (Comanthina schlegeli), which was collected from the South China Sea. Six compounds were isolated from A. brassicae 93, including one new compound (1), along with five known compounds, ochratoxin A methyl ester (2), cis-4-hydroxym-ellein (3), (R)-7-hydroxymellein (4), trans-2-anhydromevalonic (5) and protocatechuic acid (6). Their structures were determined by spectroscopic methods and comparison with reported data. Cytotoxicity against two human cancer cell lines and antibacterial activity against twelve aquatic bacteria of compound 1 were also tested.
authors.affiliation: a Schoolof Marine Sciences , SunYat-Sen University , Guangzhou , P.R. China.
authors.forename: Liu-Hong
authors.initials: LH
authors.lastname: Zhang
authors.affiliation: b School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Wang
authors.affiliation: a Schoolof Marine Sciences , SunYat-Sen University , Guangzhou , P.R. China.
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Xu
authors.affiliation: a Schoolof Marine Sciences , SunYat-Sen University , Guangzhou , P.R. China.|c South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center , Guangzhou , P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: a Schoolof Marine Sciences , SunYat-Sen University , Guangzhou , P.R. China.|d Key Laboratory of Functional Molecules from Oceanic Microorganisms, Department of Education of Guangdong Province , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
mesh_terms: D000528:Alternaria / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D062385:Hydroxybenzoates / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D049934:Isocoumarins / Q000302:isolation & purification / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008798:Mevalonic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism; D015394:Molecular Structure; D009792:Oceans and Seas; D009793:Ochratoxins / Q000302:isolation & purification / Q000378:metabolism; D064210:Secondary Metabolism; D014871:Water Microbiology
chemical_list: C000619088:2-anhydromevalonic acid; C000600633:4-hydroxymellein; C000619087:7-hydroxymellein; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D062385:Hydroxybenzoates; D049934:Isocoumarins; D009793:Ochratoxins; C025589:ochratoxin A; C009091:protocatechuic acid; D008798:Mevalonic Acid
keywords: Alternaria brassicae; Crinoid; associated fungus; secondary metabolites