title: Frequency and clinical histological analysis of glomerular diseases in a tertiary hospital in southern Brazil.
abstract: BACKGROUND
  The glomerulopathies are the most common biopsy-proven kidney diseases. The epidemiological investigation of glomerulopathies allows the identification of their distribution and main causes and enables the development of prevention and treatment strategies.
  
  
  OBJECTIVE
  This study aims to identify the frequency and clinical-pathological correlation of glomerular diseases diagnosed at the HC-UFPR over the period of 5 years.
  
  
  METHODS
  131 biopsies were performed between January 1, 2008 and December 31, 2012 and were analysed by light and immunofluorescence microscopy. Histopathological slides were reviewed by a pathologist. Clinical and laboratory data and the immunofluorescence microscopy results were extracted from medical records. The findings were tabulated and analysed.
  
  
  RESULTS
  128 of 131 cases were reanalysed. 46.5% were obtained from men. Patients' age averaged 43 years for men and 38 for women. In 99 cases, the indication of biopsy was identified; 49.5% cases presented nephrotic syndrome, 17.17%, acute renal failure and 15.15%, chronic renal failure; 8.08%, nephritic syndrome; 6.06%, isolated proteinuria and 4.04% isolated hematuria. In 61.21% an underlying disease related to the glomerulopathy could be identified; 33.62% corresponded to primary disease and in 5.17% of cases the nature of the glomerulopathy could not be determined. Among secondary glomerulopathies, the most frequent was Lupus Nephritis (49.29%), and among the primary, Focal Segmental Glomerulosclerosis (30.77%) and Membranous Nephropathy (25.64%).
  
  
  CONCLUSIONS
  The average patient with glomerulopathy in this service is an adult with nephrotic syndrome. Unlike other reports, secondary glomerulopathies were predominant. These findings may reflect the tertiary characteristic of the assistance at HC-UFPR.
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Crensiglova
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Bárbara Benevides
authors.initials: BB
authors.lastname: Rehme
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Letícia Raysa Schiavon
authors.initials: LR
authors.lastname: Kinasz
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Domingos Candiota
authors.initials: DC
authors.lastname: Chula
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Marcelo Mazza do
authors.initials: MM
authors.lastname: Nascimento
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Maria Fernanda Sanches
authors.initials: MF
authors.lastname: Soares
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001938:Brazil; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000473:pathology*; D008181:Lupus Nephritis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000175:diagnosis; D012189:Retrospective Studies; D062606:Tertiary Care Centers