title: [Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
abstract: Reproductive-aged women with epilepsy may present a number of specific issues to be managed in daily clinical practice. The impact of epileptic seizures and antiepileptic therapy on pregnancy outcome and the risk of teratogenicity should be minimized, which require careful attention and cooperation between obstetric gynecologyst and neurologist. The aim of the present paper is to review the impact of epilepsy attack on fetus and the pathomechanism and teratogenic effect of antiepileptic drugs.
authors.affiliation: Szülészeti és Nőgyógyászati Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ Szeged, Semmelweis u 1., 6725.|Mediteam Zrt. Szeged.
authors.forename: Melinda
authors.initials: M
authors.lastname: Vanya
authors.affiliation: Egészségtudományi és Egészségfejlesztő Kutató Csoport, Kecskeméti Főiskola, Tanítóképző Főiskolai Kar Kecskemét.
authors.forename: Iván
authors.initials: I
authors.lastname: Devosa
authors.affiliation: Neurológiai Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ Szeged.
authors.forename: Délia
authors.initials: D
authors.lastname: Szok
authors.affiliation: Szülészeti és Nőgyógyászati Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ Szeged, Semmelweis u 1., 6725.
authors.forename: György
authors.initials: G
authors.lastname: Bártfai
mesh_terms: D000328:Adult; D000588:Amines / Q000009:adverse effects; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D000077213:Lamotrigine; D000077287:Levetiracetam; D000078330:Oxcarbazepine; D036801:Parturition / Q000187:drug effects; D018743:Perinatal Care / Q000379:methods / Q000592:standards / Q000639:trends; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives; D016742:Preconception Care / Q000379:methods / Q000592:standards / Q000639:trends; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D013723:Teratogens; D014227:Triazines / Q000009:adverse effects; D014635:Valproic Acid / Q000009:adverse effects; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D013723:Teratogens; D014227:Triazines; D001569:Benzodiazepines; D002220:Carbamazepine; D000077287:Levetiracetam; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D010672:Phenytoin; D000077206:Gabapentin; D000077213:Lamotrigine; D000078330:Oxcarbazepine; D010634:Phenobarbital; D010889:Piracetam
keywords: antiepileptic treatment; antiepileptikumok; congenital malformations; epilepsy; epilepszia; esélyhányados; fejlődési rendellenesség; odds ratio; relative risk; relatív kockázat; teratogenity; teratogenitás