title: Adjunctive Effect of Autologus Platelet-Rich Fibrin to Barrier Membrane in the Treatment of Periodontal Intrabony Defects.
abstract: OBJECTIVE
  Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic periodontitis patients.
  
  
  METHODS
  A randomized split-mouth design was used. Sixteen patients with 32 paired intrabony defects were included. In each patient 1 defect was treated using a resorbable collagen membrane along with PRF (test group) and the other defect by guided tissue regeneration alone (control group). The following clinical parameters were measured at baseline and after 9 months: plaque index, modified sulcus bleeding index, probing pocket depth, clinical attachment level, and gingival marginal level. The radiographic defect depth was also assessed at baseline and after 9 months.
  
  
  RESULTS
  Test group showed a statistically significant improvement for probing depth (P = 0.002), clinical attachment level (P = 0.001), and radiographic defect depth (P < 0.001) after 9 months as compared with the control sites. Radiographic defect depth reduction was 58.19 ± 13.24% in the test group as compared with 24.86 ± 9.94% reduction in the control group.
  
  
  CONCLUSIONS
  The adjunctive use of PRF in combination with barrier membrane is more effective in the treatment of intrabony defects in chronic periodontitis as compared with barrier membrane alone.
authors.affiliation: *Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha†Department of Periodontia, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India‡SIOM Oral Surgery and Implantology Center, Turin§Department of Health Sciences "A. Avogadro," University of Eastern Piedmont, Novara||Department of Medicine, Surgery and Dentistry, Università degli Studi di Milano¶IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.
authors.forename: Saurav
authors.initials: S
authors.lastname: Panda
authors.forename: Malaiappan
authors.initials: M
authors.lastname: Sankari
authors.forename: Anurag
authors.initials: A
authors.lastname: Satpathy
authors.forename: Doraiswamy
authors.initials: D
authors.lastname: Jayakumar
authors.forename: Marco
authors.initials: M
authors.lastname: Mozzati
authors.forename: Carmen
authors.initials: C
authors.lastname: Mortellaro
authors.forename: Giorgia
authors.initials: G
authors.lastname: Gallesio
authors.forename: Silvio
authors.initials: S
authors.lastname: Taschieri
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Fabbro
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D001792:Blood Platelets; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery*; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D005337:Fibrin