title: Aortic Intimal Sarcoma Contributes to Atherosclerotic Renovascular Hypertension: An Autopsy Case Report and Review of the Literature.
abstract: An autopsy of a 70-year-old man with multiple bone metastases from a malignancy of unknown origin (MUO) and renovascular hypertension revealed an aortic intimal sarcoma (AIS) in the right renal artery accompanied by atherosclerotic changes. AIS appeared as aggregated mutton fat-like translucent particles arising from the intima of the branching portion of the right renal artery and was composed of undifferentiated, fine spindle cells with thicket-like proliferation. AIS was confirmed by immunohistopathology, showing the loss of the lumen lined by CD31-positive endothelium and the expression of CD31, keratin, and vimentin in the viable part of the tumor. In patients with MUO presenting with both bone metastases and an acute or sub-acute onset of renovascular hypertension, AIS in the renal artery may be responsible.
authors.affiliation: Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ishii
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugawara
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nokubi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Okochi
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Michiko
authors.initials: M
authors.lastname: Matsuzawa
authors.forename: Tamami
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kakei
authors.forename: Wilfred Y
authors.initials: WY
authors.lastname: Fujimoto
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Momomura
mesh_terms: D000368:Aged; D001013:Aorta, Thoracic / Q000473:pathology*; D001157:Arterial Occlusive Diseases / Q000473:pathology*; D001161:Arteriosclerosis / Q000150:complications*; D001344:Autopsy; D001859:Bone Neoplasms / Q000556:secondary*; D004417:Dyspnea / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D006978:Hypertension, Renovascular / Q000209:etiology / Q000473:pathology*; D008297:Male; D012509:Sarcoma / Q000150:complications / Q000473:pathology*; D017539:Tunica Intima / Q000473:pathology*; D019043:Vascular Neoplasms / Q000150:complications / Q000473:pathology*