title: RenalGuard System for the prevention of acute kidney injury in patients undergoing transcatheter aortic valve implantation.
abstract: OBJECTIVE
  We aimed to assess whether the RenalGuard™ System is effective in preventing acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI).
  
  
  RESULTS
  Forty-eight consecutive patients with chronic kidney disease (CKD) scheduled for TAVI were assigned to: 1) hydration with sodium bicarbonate solution (Control group), or 2) hydration with RenalGuard Therapy (RenalGuard group). Hypotension was defined as periprocedural mean blood pressure <55 mmHg. The primary endpoint was the occurrence of AKI (i.e., an increase of ≥0.3 mg/dL in the serum creatinine concentration at seven days). AKI occurred in 10/26 (38.5%) patients in the Control group and in 1/22 (4.5%) patients in the RenalGuard group (p=0.005, odds ratio [OR] 0.076, 95% confidence interval [CI]: 0.009-0.66). RenalGuard Therapy protected against AKI (OR 0.71, 95% CI: 0.07-0.775, p=0.026), whereas post-procedural hypotension (OR 3.88, 95% CI: 1.06-14.24, p=0.040), and contrast media volume (OR 3.65, 95% CI: 1.15-5.75, p=0.043) increased the risk of AKI.
  
  
  CONCLUSIONS
  This non-randomised pilot study suggests that RenalGuard Therapy may be effective in preventing AKI in CKD patients undergoing TAVI.
authors.affiliation: Laboratory of Interventional Cardiology and Department of Cardiology, Clinica Mediterranea, Naples, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Visconti
authors.forename: Amelia
authors.initials: A
authors.lastname: Focaccio
authors.forename: Michael
authors.initials: M
authors.lastname: Donahue
authors.forename: Bruno
authors.initials: B
authors.lastname: Golia
authors.forename: Antonio
authors.initials: A
authors.lastname: Marzano
authors.forename: Elvira
authors.initials: E
authors.lastname: Donnarumma
authors.forename: Bruno
authors.initials: B
authors.lastname: Ricciardelli
authors.forename: Lucio
authors.initials: L
authors.lastname: Selvetella
authors.forename: Luigi
authors.initials: L
authors.lastname: Marino
authors.forename: Carlo
authors.initials: C
authors.lastname: Briguori
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology / Q000517:prevention & control* / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000628:therapy*; D006328:Cardiac Catheterization / Q000379:methods; D003404:Creatinine / Q000097:blood; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008297:Male; D012307:Risk Factors; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods; D016896:Treatment Outcome
chemical_list: D003404:Creatinine