title: Energy metabolic dysfunction as a carcinogenic factor in cancer cells.
abstract: Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunction, and various cancers. We found that most environmental pollution factors could induce cancers mainly by disturbing the energy metabolism. By triggering microenvironment alteration, energy metabolic dysfunction can be treated as a factor in carcinogenesis. Thus, we put forward that energy metabolism might be as a key point for studying carcinogenesis and tumor development to propose new methods for cancer prevention and therapy.
authors.affiliation: Physical Environment Laboratory, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Avenue, Xiamen, 361021, People's Republic of China.|University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China.
authors.forename: Yongyan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Environmental Bioelectrochemistry Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, People's Republic of China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Physical Environment Laboratory, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Avenue, Xiamen, 361021, People's Republic of China.
authors.forename: Huiyong
authors.initials: H
authors.lastname: Lian
authors.affiliation: Physical Environment Laboratory, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Avenue, Xiamen, 361021, People's Republic of China. pcai@iue.ac.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Cai