title: Scleral and corneal xanthomatous inflammation in a gray mouse lemur (Microcebus murinus).
abstract: Bilateral multifocal corneal opacity was detected in a 4.5-year-old male captive gray mouse lemur (Microcebus murinus) without other clinical ocular changes. Histopathological examination revealed a severe diffuse granulomatous scleritis and focal keratitis with intralesional cholesterol, consistent with xanthomatous inflammation. This is the first report of xanthomatous inflammation in a gray mouse lemur. This condition may be the result of systemic factors (lipid metabolism disorders) and/or local predisposing factors such as hemorrhage or inflammation. The pathogenesis in this case could not be fully determined. Further studies on lemurs are required for a better understanding of their lipid metabolism, as well as for diagnosing and evaluating the incidence of xanthomatous inflammation in these species.
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort, Unité d'Histologie Embryologie et Anatomie pathologique, Université Paris-Est, Maisons-Alfort, F-94704, France.
authors.forename: Charline
authors.initials: C
authors.lastname: Alleaume
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort, Unité d'Histologie Embryologie et Anatomie pathologique, Université Paris-Est, Maisons-Alfort, F-94704, France.
authors.forename: Meryem El
authors.initials: ME
authors.lastname: Mrini
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort, Unité d'Histologie Embryologie et Anatomie pathologique, Université Paris-Est, Maisons-Alfort, F-94704, France.
authors.forename: Eve
authors.initials: E
authors.lastname: Laloy
authors.affiliation: Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Mécanismes Adaptatifs et Evolution, Brunoy, F-91800, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Marchal
authors.affiliation: Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Mécanismes Adaptatifs et Evolution, Brunoy, F-91800, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort, UP Ophtalmologie, Université Paris-Est, Maisons-Alfort, F-94704, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Chahory
mesh_terms: D000818:Animals; D016565:Cheirogaleidae; D007634:Keratitis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D015423:Scleritis / Q000473:pathology / Q000662:veterinary*; D014973:Xanthomatosis / Q000473:pathology / Q000662:veterinary*
keywords: 
  Microcebus murinus
  ; cornea; gray mouse lemur; sclera; xanthomatous inflammation