title: Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling.
abstract: Improving efficacy of immune checkpoint blockade for cancer can be facilitated by combining these agents with each other and/or with other conventional or targeted therapies. Interferon and innate immune signaling pathways in immune and tumor cells have emerged as intriguing determinants of response and resistance, often in complex and seemingly paradoxical ways.
authors.affiliation: Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: andyminn@mail.med.upenn.edu.
authors.forename: Andy J
authors.initials: AJ
authors.lastname: Minn
authors.affiliation: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: E John
authors.initials: EJ
authors.lastname: Wherry
mesh_terms: D000818:Animals; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007372:Interferons / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000628:therapy*; D015398:Signal Transduction
chemical_list: D007372:Interferons