title: Rhodium-catalyzed chemo- and regioselective decarboxylative addition of β-ketoacids to alkynes.
abstract: A highly efficient rhodium-catalyzed chemo- and regioselective addition of β-ketoacids to alkynes is reported. Applying a Rh(i)/(S,S)-DIOP catalyst system, γ,δ-unsaturated ketones were prepared with exclusively branched selectivity under mild conditions. This demonstrates that readily available alkynes can be an alternative entry to allyl electrophiles in transition-metal catalyzed allylic alkylation reactions.
authors.affiliation: Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg im Breisgau, Germany. bernhard.breit@chemie.uni-freiburg.de.
authors.forename: Changkun
authors.initials: C
authors.lastname: Li
authors.forename: Christian P
authors.initials: CP
authors.lastname: Grugel
authors.forename: Bernhard
authors.initials: B
authors.lastname: Breit
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D007651:Keto Acids / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007651:Keto Acids; D007659:Ketones; D012238:Rhodium