title: The promise and challenge of epitope-focused vaccines.
abstract: Traditional vaccination with whole pathogens or pathogen-derived subunits has completely eliminated diseases like smallpox, and has greatly limited the incidence, morbidity and mortality associated with many other infectious diseases. Unfortunately, a large burden of infectious disease remains that may be preventable through vaccination. For many of these, more focused and innovative approaches may be essential for the development of effective vaccines.
authors.affiliation: a Division of Hematology-Oncology, Department of Internal Medicine , University of Michigan Medical School , Ann Arbor , MI , USA.|b Veterans Administration Ann Arbor Healthcare System , Ann Arbor , MI , USA.
authors.forename: Jon
authors.initials: J
authors.lastname: Oscherwitz
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology*; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D014612:Vaccines / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D000939:Epitopes; D014612:Vaccines
keywords: antibody; epitope-focused; immunization; peptide; vaccine