title: A Hospital Based Study to Establish the Correlation between Recurrent Wheeze and Vitamin D Deficiency Among Children of Age Group Less than 3 Years in Indian Scenario.
abstract: BACKGROUND
  Early childhood wheezing is a heterogeneous condition, which has several phenotypic expressions and a complex relationship with the development of asthma later in life. New studies indicate the prevalence of recurrent wheeze to be associated with Vitamin D deficiency. This has not been explored in Indian settings widely, mandating this exploration.
  
  
  OBJECTIVE
  To determine the severity of Vitamin D deficiency and its association with recurrent wheeze in children less than 3 years of age.
  
  
  METHODS
  Consecutive type of non-probability sampling was followed for selection of study subjects with a total sample size to be 122 children in the Hospital setting. A pre- formed, pre- tested, structured interview schedule was used to obtain information. Estimation of 25 (OH) Vitamin D was done using ELISA method. Kit used for estimation was DLD Diagnostika GMBH 25(OH) Vitamin D ELISA from Germany. Standard statistical tools were used including Logistic regression analysis, and ROC curve, p value <0.05 was considered to be statistically significant. SPSS software version 17.0 was used.
  
  
  RESULTS
  Each 10ng/ml decrease in Vitamin D level is associated with 7.25% greater odds of wheezing. Our study also suggests, exclusive breast feeding and delaying of complementary feeding beyond 6 months of age are significant predictors of Vitamin D deficiency and have indirect association with increased incidence of wheezing in children.
  
  
  CONCLUSIONS
  The study concluded that Vitamin D deficiency is associated with increased risk of recurrent wheezing.
authors.affiliation: Senior Registrar, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital Sion Mumbai, Mumbai, Maharasthra, India .
authors.forename: Santosh
authors.initials: S
authors.lastname: Prasad
authors.affiliation: Epidemiologist, Department of Community Medicine, Life Member Indian Medical Association, International Epidemiological Association (USA) , IAPSM, India .
authors.forename: Rishabh Kumar
authors.initials: RK
authors.lastname: Rana
authors.affiliation: Senior Registrar, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital Sion Mumbai, Mumbai, Maharasthra, India .
authors.forename: Ronak
authors.initials: R
authors.lastname: Sheth
authors.affiliation: Addtnl Professor, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital Sion Mumbai, Mumbai, Maharasthra, India .
authors.forename: Anupama V
authors.initials: AV
authors.lastname: Mauskar
keywords: Delayed complementary feed; Early childhood; Exclusive breast feeding; Logistic regression analysis; Predictors