title: A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids.
abstract: A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.
authors.affiliation: Laboratoire de Synthèse Organique, CNRS UMR 7652 Ecole Polytechnique , 91128 Palaiseau, Cedex, France.
authors.forename: Shi-Guang
authors.initials: SG
authors.lastname: Li
authors.affiliation: Laboratoire de Synthèse Organique, CNRS UMR 7652 Ecole Polytechnique , 91128 Palaiseau, Cedex, France.
authors.forename: Fernando
authors.initials: F
authors.lastname: Portela-Cubillo
authors.affiliation: Laboratoire de Synthèse Organique, CNRS UMR 7652 Ecole Polytechnique , 91128 Palaiseau, Cedex, France.
authors.forename: Samir Z
authors.initials: SZ
authors.lastname: Zard
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D054879:Halogenation; D008026:Ligation; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D013438:Sulfhydryl Compounds