title: Effect of faeces trogopterorum extract B1 on the experimental gastric ulcer and gastric secretion in rats.
abstract: OBJECTIVE
  To study the effects of extracts B1, B2, and B3 from faeces trogopterorum on the experimental gastric ulcer in rats.
  
  
  METHODS
  Two different animal models of gastric ulcers were used in this experiment: Shay's model (n = 72) and the reserpine-induced ulcer model (n = 76). The total volume and the pH of the gastric juices were recorded. The lesion scores of gastric mucosa were also recorded.
  
  
  RESULTS
  The lesion scores of gastric mucosa in the Shay's model of animals in the WLZ-B1 groups treated with either 40 g/kg or 80 g/kg were 8.6 ± 10.8 and 1.6 ± 1.9 respectively, which were lower than that of the 0.9% NaCl control group (47.0 ± 31.4, P < 0.05, P < 0.01). The lesion scores for the 80 g/kg group was lower compared to those of the Ran group (20.5 ± 16.4, P < 0.01). The pH of the gastric juices of the 80 g/kg group (3.425 ± 0.143) was higher than that of the 0.9% NaCl group (2.836 ± 0.632, P < 0.05). In the reserpine model, the lesion score of the 40 g/kg group of the WLZ-B1 (20.7 ± 16.5) was also lower than that of the 0.9% NaCl control group (76.3 ± 50.6, P < 0.05).
  
  
  CONCLUSIONS
  B1 is the most effective of the three sections in inhibiting gastric secretion, protecting gastric mucosa and preventing experimental ulceration.
authors.affiliation: Xiong-Wen Wang, Zhi-An Cheng, Qing-Ming Li, Wen-Zi Liu, Department of Traditional Chinese Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Seiences, Guangzhou 510120, Guangdong Province, China.
authors.forename: X W
authors.initials: XW
authors.lastname: Wang
authors.affiliation: Xiong-Wen Wang, Zhi-An Cheng, Qing-Ming Li, Wen-Zi Liu, Department of Traditional Chinese Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Seiences, Guangzhou 510120, Guangdong Province, China.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Cheng
authors.affiliation: Xiong-Wen Wang, Zhi-An Cheng, Qing-Ming Li, Wen-Zi Liu, Department of Traditional Chinese Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Seiences, Guangzhou 510120, Guangdong Province, China.
authors.forename: Q M
authors.initials: QM
authors.lastname: Li
authors.affiliation: Xiong-Wen Wang, Zhi-An Cheng, Qing-Ming Li, Wen-Zi Liu, Department of Traditional Chinese Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Seiences, Guangzhou 510120, Guangdong Province, China.
authors.forename: W Z
authors.initials: WZ
authors.lastname: Liu
keywords: Faeces trogopterori/pharmacology; Gastric mucosa/drug effects; Stomach ulcer/prevention and control