title: Partially restored resting-state functional connectivity in women recovered from anorexia nervosa.
abstract: We have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and the default mode network (DMN) in patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC in patients recovered from anorexia nervosa to examine whether these abnormalities are a state or trait marker of the disease. To extend the understanding of functional connectivity in patients with anorexia nervosa, we also estimated rsFC between large-scale networks.
  
  
  
  Girls and women recovered from anorexia nervosa and pair-wise, age- and sex-matched healthy controls underwent a resting-state fMRI scan. Using independent component analyses (ICA), we isolated the FPN, DMN and salience network. We used standard comparisons as well as a hypothesis-based approach to test the findings of our previous rsFC study in this recovered cohort. Temporal correlations between network time-course pairs were computed to investigate functional network connectivity (FNC).
  
  
  
  Thirty-one patients recovered from anorexia nervosa and 31 controls participated in our study. Standard group comparisons revealed reduced rsFC between the dorsolateral prefrontal cortex (dlPFC) and the FPN in the recovered group. Using a hypothesis-based approach we extended the previous finding of increased rsFC between the angular gyrus and the FPN in patients recovered from anorexia nervosa. No group differences in FNC were revealed.
  
  
  
  The study design did not allow us to conclude that the difference found in rsFC constitutes a scar effect of the disease.
  
  
  
  This study suggests that some abnormal rsFC patterns found in patients recovered from anorexia nervosa normalize after long-term weight restoration, while distorted rsFC in the FPN, a network that has been associated with cognitive control, may constitute a trait marker of the disorder.
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Ilka
authors.initials: I
authors.lastname: Boehm
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Daniel
authors.initials: D
authors.lastname: Geisler
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Friederike
authors.initials: F
authors.lastname: Tam
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Joseph A
authors.initials: JA
authors.lastname: King
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Franziska
authors.initials: F
authors.lastname: Ritschel
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Maria
authors.initials: M
authors.lastname: Seidel
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Fabio
authors.initials: F
authors.lastname: Bernardoni
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Julia
authors.initials: J
authors.lastname: Murr
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Thomas
authors.initials: T
authors.lastname: Goschke
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Veit
authors.initials: V
authors.lastname: Roessner
authors.affiliation: From the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
mesh_terms: D000856:Anorexia Nervosa / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D012146:Rest; D055815:Young Adult