title: Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases.
abstract: The aim of the present study was to quantify neuropathological findings using image analysis software for the diagnosis of dementia in deceased who underwent forensic autopsy. Of the autopsies performed within 48 hours of death and excluding those of patients with head injury, thermal injury, heat stroke, or intracranial lesions, 8 were of autopsy cases clinically diagnosed with dementia and thus included in the dementia group (D). The non-dementia group (non-D) consisted of 6 deceased without dementia. To compare the D and non-D groups, 6 regions and 7 types of pathological findings were observed semi-quantitatively using 4 conventional stainings. Quantitative analysis of collected image data was performed using image analysis software. Semiquantitative analysis of senile plaques and neurofibrillary tangles was performed with Bielschowsky-Hirano's silver staining image data. An easy, simple, and effective quantification method of the pathological findings was achieved. However, no significant differences were observed between the two groups, and diagnosis of dementia by the quantification of pathological findings was not successful. Diagnosis of dementia using image data may be possible in future studies with an increased number of autopsies, and by utilizing staining techniques with higher specificity and sensitivity, such as immunohistochemical staining.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Fukuoka University.
authors.forename: Mio
authors.initials: M
authors.lastname: Takayama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kashiwagi
authors.forename: Aya
authors.initials: A
authors.lastname: Matsusue
authors.forename: Brian
authors.initials: B
authors.lastname: Waters
authors.forename: Kenji
authors.initials: K
authors.lastname: Hara
authors.forename: Natsuki
authors.initials: N
authors.lastname: Ikematsu
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kubo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D016022:Case-Control Studies; D003704:Dementia / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging / Q000473:pathology