title: The possible role of serum leptin in preeclampsia.
abstract: BACKGROUND
  It is theorized that adipokines play a critical role in the pathophysiology of preeclampsia, particularly with their pro-inflammatory and inflammatory features.
  
  
  OBJECTIVE
  To investigate serum leptin levels in pregnancies complicated with preeclampsia and severe preeclampsia.
  
  
  METHODS
  Maternal serum leptin levels were analyzed by solid phase enzyme amplified sensitivity immunoassay (EASIA) method in 23 patients with mild preeclampsia, 29 patients with severe preeclampsia, and 28 healthy pregnant controls.
  
  
  RESULTS
  Mean serum leptin levels did not differ statistically between patients with mild preeclampsia, severe preeclampsia, and the controls (10.77 ng/ml, 13.40 ng/ml, and 8.43 ng/ml, respectively). Also, there was no relationship between serum leptin levels and the gestational ages of the participants.
  
  
  CONCLUSIONS
  Serum leptin levels are not associated with preeclampsia. Leptin measurements are not affected with the gestational age. The role of leptin in the pathophysiology of preeclampsia should be evaluated cautiously.
authors.forename: Y
authors.initials: Y
authors.lastname: Doster
authors.forename: B
authors.initials: B
authors.lastname: Cetinkaya Demir
authors.forename: M A
authors.initials: MA
authors.lastname: Atalay
authors.forename: E E
authors.initials: EE
authors.lastname: Durusoy
authors.forename: S
authors.initials: S
authors.lastname: Kucukkomurcu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D020738:Leptin