title: Role of MicroRNA in Governing Synaptic Plasticity.
abstract: Although synaptic plasticity in neural circuits is orchestrated by an ocean of genes, molecules, and proteins, the underlying mechanisms remain poorly understood. Recently, it is well acknowledged that miRNA exerts widespread regulation over the translation and degradation of target gene in nervous system. Increasing evidence suggests that quite a few specific miRNAs play important roles in various respects of synaptic plasticity including synaptogenesis, synaptic morphology alteration, and synaptic function modification. More importantly, the miRNA-mediated regulation of synaptic plasticity is not only responsible for synapse development and function but also involved in the pathophysiology of plasticity-related diseases. A review is made here on the function of miRNAs in governing synaptic plasticity, emphasizing the emerging regulatory role of individual miRNAs in synaptic morphological and functional plasticity, as well as their implications in neurological disorders. Understanding of the way in which miRNAs contribute to synaptic plasticity provides rational clues in establishing the novel therapeutic strategy for plasticity-related diseases.
authors.affiliation: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Department of Neurosurgery, Second Affiliated Hospital of Hunan Normal University (PLA 163 Hospital), Changsha 410000, China.
authors.forename: Yuqin
authors.identifier: 0000-0001-5645-910X
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Hongyu
authors.identifier: 0000-0001-6662-6928
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xinhong
authors.identifier: 0000-0002-8705-8541
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xiaosheng
authors.identifier: 0000-0002-2979-9317
authors.initials: X
authors.lastname: He
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D049229:Dendritic Spines / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology*; D009473:Neuronal Plasticity
chemical_list: D035683:MicroRNAs