title: Mixed cryoglobulinemia-associated Sjögren's syndrome leading to spontaneous rupture of the kidney: a case report.
abstract: BACKGROUND
  Spontaneous rupture of the kidney is uncommon and is mainly caused by renal tumors. Only a few cases are caused by vasculitis. We report here the first case of spontaneous rupture of kidney resulting from mixed cryoglobulinemia.
  
  
  METHODS
  A 44-year-old man presented with sudden onset of fever, acute pulmonary edema, left flank abdominal pain unassociated with trauma, and rapidly progressive renal failure requiring dialysis. Computed tomography of the abdomen revealed a large perirenal hematoma of the left kidney. During conservative surgery, the patient underwent renal biopsy that showed renal vasculitis and membranoproliferative glomerulonephritis with intracapillary microthrombi. Tests were positive for mixed cryoglobulinemia caused by Sjögren's syndrome. The patient was better after immunosuppressive therapy, with the disappearance of clinical symptoms and the recovery of baseline renal function.
  
  
  CONCLUSIONS
  We report on this case and discuss a possible link between spontaneous rupture of kidney and mixed cryoglobulinemia-associated Sjögren's syndrome.
authors.affiliation: Department of Nephrology-Dialysis-Renal Transplantation, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Intissar
authors.initials: I
authors.lastname: Haddiya
authors.affiliation: Department of Nephrology-Dialysis-Renal Transplantation, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Hakim
authors.initials: H
authors.lastname: Hamzaoui
authors.affiliation: Department of Pathology, Rabat Children's Hospital, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Zitouna
authors.initials: Z
authors.lastname: Alhamany
authors.affiliation: Department of Nephrology-Dialysis-Renal Transplantation, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Fatime-Zohra
authors.initials: FZ
authors.lastname: Berkchi
authors.affiliation: Department of Nephrology-Dialysis-Renal Transplantation, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Hakima
authors.initials: H
authors.lastname: Rhou
authors.affiliation: Department of Nephrology-Dialysis-Renal Transplantation, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Loubna
authors.initials: L
authors.lastname: Benamar
authors.affiliation: Department of Nephrology-Dialysis-Renal Transplantation, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Naima
authors.initials: N
authors.lastname: Ouzeddoun
authors.affiliation: Department of Nephrology-Dialysis-Renal Transplantation, Ibn Sina University Hospital, Rabat, Morocco.
authors.forename: Rabea
authors.initials: R
authors.lastname: Bayahia
keywords: Sjögren’s syndrome; Wünderlich syndrome; mixed cryoglobulinemia; renal hematoma; spontaneous rupture of kidney