title: Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma.
abstract: Oesophageal carcinoma is one of the most lethal cancer types in the world, especially in some part of China. Oesophageal squamous cell carcinoma (OSCC) is a major subtype, which has been shown to be associated with unhealthy diet habit, smoking, environmental carcinogens etc. The OSCC often progress slowly, however, it is often diagnosed at an advanced stage. Thus it is imperative to elucidate the molecular mechanisms involved in the initiation and progression of OSCC. Long noncoding RNAs (lncRNA) has emerged as a novel functional player transcribed from the genome. Here, we describe a novel lncRNA POU6F2-AS2 specifically expressed in OSCC. POU6F2-AS2 is involved in the DNA damage response and regulates cells survival after ionizing radiation. POU6F2-AS2 interacts with Ybx1 protein and regulates its chromatin localization. Our current study represents the first description of an OSCC associated lncRNA that modulates DNA repair.
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China and.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiotherapy, The 81st Hospital of PLA, Yanggongjing 34, Nanjing 210002, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China and.
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China and.
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China and.
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China and xchensun@sina.com.
authors.forename: Xinchen
authors.initials: X
authors.lastname: Sun
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D002470:Cell Survival / Q000528:radiation effects; D004260:DNA Repair; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D000077277:Esophageal Squamous Cell Carcinoma; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D062085:RNA, Long Noncoding / Q000096:biosynthesis* / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis* / Q000235:genetics; D011836:Radiation Tolerance / Q000528:radiation effects; D011839:Radiation, Ionizing
chemical_list: D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm
keywords: DNA repair; cancer; ionizing radiation; long noncoding RNAs; oesophageal squamous cell carcinoma