title: Immunohistochemical study of gastrin in colorectal carcinoma tissues and adjacent mucosa.
abstract: OBJECTIVE
  To study gastrin expression in colorectal carcinoma tissues and adjacent mucosa and discuss the function of gastrin in colorectal carcinoma.
  
  
  METHODS
  Gastrin expression in colorectal carcinoma tissues and adjacent mucosa was examined in 58 cases using immunohistochemical and immunoelectron microscopy.
  
  
  RESULTS
  A total of 35.1% of colorectal carcinoma transitional mucosa (TM), 48.3% of nontypical dysplasia mucosa and 60.3% of carcinoma tissue were positive for gastrin expression (P < 0.05). Immunoelectron microscopy revealed that protein A gold (PAG) granules localized to different electron-dense secretory granules in carcinoma cells, the intercellular spaces, and the microvillar membrane surface.
  
  
  CONCLUSIONS
  Gastrin expression in colorectal carcinoma tissue and adjacent mucosa, and the release of gastrin by carcinoma may be an initiating factor in carcinoma occurrence and development. Positive gastrin expression in colorectal carcinoma tissues can serve as a differentiation marker.
authors.affiliation: Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China.
authors.forename: C P
authors.initials: CP
authors.lastname: Jiang
authors.affiliation: Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Chen
authors.affiliation: Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China.
authors.forename: J W
authors.initials: JW
authors.lastname: Zhu
authors.affiliation: Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China.
authors.forename: H X
authors.initials: HX
authors.lastname: Shen
authors.affiliation: Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China.
authors.forename: X
authors.initials: X
authors.lastname: Yu
keywords: Colorectal neoplasms; Electron; Gastrin; Immunohistochemistry; microscopy