title: Modelling Chemotherapy-induced Cardiotoxicity by Human Pluripotent Stem Cells.
abstract: Novel antineoplastic therapies have greatly improved cancer survival; nevertheless they are bringing in new forms of cardiomyopathy, that can often limit proper cancer treatments. Novel cardioprotective therapies are therefore needed, for improving clinical outcomes in cancer patients. In order to test novel therapeutic strategies, there is an increasing need for appropriate experimental models of chemotherapy-induced cardiomyopathy. Induced pluripotent stem (iPS) cell- and human embryonic stem cell (hESC )-derived cardiomyocytes may be used as alternative in vitro models for studying mechanisms that underly chemotherapy-induced cardiomyopathy. In this review we discuss the use of iPS- and hESC-derived cardiomyocytes for evaluating additional pharmacological targets and for predicting chemotherapy-induced cardiotoxicity.
authors.affiliation: Dipartimento di Scienze Mediche Mario Aresu, Universita of Cagliari, Italy.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Madonna
authors.affiliation: Department of Medical Sciences "Mario Aresu", University of Cagliari, Cagliari, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Cadeddu
authors.affiliation: Department of Medical Sciences "Mario Aresu", University of Cagliari, Cagliari, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: Deidda
authors.affiliation: Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Spallarossa
authors.affiliation: U.O.C. Cardiology Intensive Unit, A.O.U. Policlinico "G. Martino", University of Messina, Messina, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Zito
authors.affiliation: Department of Medical Sciences "Mario Aresu", University of Cagliari, Cagliari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mercuro
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D066126:Cardiotoxicity; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents
keywords: Cardiac stem cells; cardiomyopathy; chemotherapy-induced cardiotoxicity; human embryomic stem cell; pluripotent stem cells; preclinical models