title: Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
abstract: N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical Scientist Training Program, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Roundtree
authors.affiliation: Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics and Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.
authors.forename: Chuan
authors.initials: C
authors.lastname: He
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000235:genetics; D056890:Eukaryota / Q000235:genetics; D008745:Methylation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D012326:RNA Splicing / Q000235:genetics*; D000072260:RNA Splicing Factors / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D059467:Transcriptome / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D000072260:RNA Splicing Factors; D012333:RNA, Messenger; C490769:YTHDC1 protein, human; C010223:N-methyladenosine; D000241:Adenosine
keywords: N(6)-methyladenosine; YTHDC1; mRNA splicing