title: Fertility outcome after laparoscopic treatment of advanced endometriosis in two groups of infertile patients with and without ovarian endometrioma.
abstract: OBJECTIVE
  To evaluate the result of laparoscopic endometrioma excision in fertility outcome of advanced endometriosis patients.
  
  
  METHODS
  The study was designated as historical cohort, in a private referral center of advance laparoscopy. 111 infertile patients, diagnosed as endometriosis, were divided in two groups: DIE (deep infiltrative endometriosis) and endometrioma (case group), and patients with only DIE (without endometrioma ((control group). All patients underwent global laparoscopic resection of DIE lesion (both groups) and laparoscopic excisional cystectomy of endometrioma (case groups). Patients were followed for fertility outcomes and data were analyzed by Kaplan-Meier test and COX regression using SPSS software.
  
  
  RESULTS
  After adjusting covariates, the Kaplan-Meier analysis of cumulative pregnancy rates (CPR) did not show any statistical significance between cases (35.6%) and controls (39.5%) (Log-rank P-value=0.959). The COX regression analysis of covariates showed there is no significant relationship between cystectomy and fertility outcome. It showed statistical significance effect of age (hazard ratio [HR]=0.772), years of infertility (HR=0.224), and previous endometrioma surgery (HR=0.180), on fertility chance.
  
  
  CONCLUSIONS
  In advanced endometriosis with DIE and infertility, fine excision and stripping of the endometrioma along with radical resection of DIE improves fecundity without any significant adverse effect in comparison with patients with intact ovaries.
authors.affiliation: Independent Research Consultant, FACOG, Iran; Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran. Electronic address: adelshervin@gmail.com.
authors.forename: Adel
authors.initials: A
authors.lastname: Shervin
authors.affiliation: Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Immunology Research Center, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Mohazzab
authors.affiliation: Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Aminlou
authors.affiliation: Avicenna Research Institute, ACECR, Reproductive Immunology Research Center, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.
authors.forename: Koorosh
authors.initials: K
authors.lastname: Kamali
authors.affiliation: Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Padmehr
authors.affiliation: Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Shadjoo
authors.affiliation: Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Jaberi-Pour
authors.affiliation: Independent Research Consultant, FACOG, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Akbari
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007247:Infertility, Female / Q000601:surgery*; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies
keywords: Advance endometriosis; Deep infiltrative endometriosis; Excisional cystectomy; Fertility outcome; Infertility; Ovarian endometrioma