title: Regeneration strategies after the adult mammalian central nervous system injury-biomaterials.
abstract: The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such as cell and/or drug delivery, has been demonstrated to have some therapeutic effects on experimental animal models, but can hardly find clinical applications due to such methods as the extremely low survival rate of transplanted cells, difficulty in integrating with the host or restriction of blood-brain barriers to administration patterns. Using biomaterials can not only increase the survival rate of grafts and their integration with the host in the injured CNS area, but also sustainably deliver bioproducts to the local injured area, thus improving the microenvironment in that area. This review mainly introduces the advances of various strategies concerning facilitating CNS regeneration.
authors.affiliation: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
authors.forename: Yudan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China,; Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China,; Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Li
keywords: axonal regeneration; biomaterials; central nervous system injury; neural stem/precursor cell; neurogenesis