title: Decreased serum levels of T-cell immunoglobulin mucin-1 and T-cell immunoglobulin mucin-3 in systemic lupus erythematosus patients.
abstract: This study aims to investigate the serum T-cell immunoglobulin mucin (TIM)-1 and TIM-3 levels in systemic lupus erythematosus (SLE) patients and analyze their correlations with clinical features. Sixtyone SLE patients and 69 healthy controls were enrolled, serum TIM-1 and TIM-3 levels were detected by ELISA. Results demonstrated that both serum TIM-1 and TIM-3 levels were significantly decreased in SLE patients compared with controls (both P less than 0.05). Lower serum TIM-3 levels in SLE patients with nephritis were observed when compared to those without nephritis, with a marginal statistical significance (P=0.059). However, both serum TIM-1 and TIM-3 levels had no significant correlation with SLE disease activity (both >0.05). In summary, decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of SLE. However, further studies are needed to confirm these preliminary results.
authors.affiliation: Department of Preventive Medicine, Wannan Medical College, Wuhu, Anhui, China.
authors.forename: H
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Preventive Medicine, Wannan Medical College, Wuhu, Anhui, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Yao
authors.affiliation: School of Health Management, Anhui Medical University, Hefei, Anhui, China.
authors.forename: G M
authors.initials: GM
authors.lastname: Chen
authors.affiliation: Department of Rheumatology and Immunology, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui China.
authors.forename: J
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Department of Rheumatology and Immunology, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui China.
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Pan
mesh_terms: D000328:Adult; D000072596:Hepatitis A Virus Cellular Receptor 1; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008565:Membrane Proteins / Q000097:blood*; D011991:Receptors, Virus / Q000097:blood*
chemical_list: C491143:HAVCR1 protein, human; C448908:HAVCR2 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D000072597:Hepatitis A Virus Cellular Receptor 2; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011991:Receptors, Virus