title: Investigating Preoperative Hematologic Markers for Prediction of Ovarian Cancer Surgical Outcome.
abstract: OBJECTIVE
  The current study aimed at assessing the association between neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) for the prognosis of the surgical outcome of epithelial ovarian cancer (EOC).
  
  
  METHODS
  EOC patient medical records of surgical operations between January, 2005 and December, 2015 were reviewed and their data of clinicopathological complete blood counts (CBCs) and surgical outcomes were collected. To assess their effects on surgical outcomes, PLR and NLR optimal predictive values were determined and then compared with each other.
  
  
  RESULTS
  A statistically significant relation was found between surgical outcomes and NLR and PLR (p<0.001 and p<0.001), for which new cutoff points were gained (PLR: 192,3,293; NLR: 3). The sensitivity and specificity were 0.74 and 0.67, respectively for PLR and 0.74 and 0.58, for NLR.
  
  
  CONCLUSIONS
  NLR and PLR seem to be useful methods for the prediction of surgical outcomes in patients with EOCs. Increased NLR and PLR proved to be beneficial for poor surgical outcomes. Moreover, PLR increase showed further help in the predicting outcome of EOC suboptimal debulking.
authors.affiliation: Gyneco-Oncology, Preventative Gynecology Research Center (PGRC). Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail : amiri_mahdis@yahoo.com.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Ashrafganjoei
authors.forename: Mahdiss
authors.initials: M
authors.lastname: Mohamadianamiri
authors.forename: Farah
authors.initials: F
authors.lastname: Farzaneh
authors.forename: Maryam Sadat
authors.initials: MS
authors.lastname: Hosseini
authors.forename: Maliheh
authors.initials: M
authors.lastname: Arab
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001792:Blood Platelets / Q000473:pathology*; D018284:Cystadenocarcinoma, Serous / Q000473:pathology / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor