title: [ABSOLUTE AND RELATIVE BIOAVAILABILITY OF GLUTARON--A NEW DERIVATIVE OF GLUTAMIC ACID].
abstract: The pharmacokinetics of studies of 3-phenylglutamic acid hydrochloride (glutaron) has been studied in rats. The main pharmacokinetic parameters show low values of the half-life (T1/2 = 3.75 h), mean retention time in the body (MRT = 5.77 h). The medium rate of drug concentration decrease in the blood plasma leads to a low value of the area under pharmacokinetic curve (AUC = 41.18 mg · h/mL). The general volume of distribution (Vd = 3.42 L/kg) is 3.5 times greater than the volume of extracellular fluid in the rat body. These data indicate a high ability of the glutaron to be distributed and accumulated in animal tissues. The value of absolute bioavailability is 84%, and the relative bioavailabity is 100%.
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: A F
authors.initials: AF
authors.lastname: Ryabukha
authors.forename: K A
authors.initials: KA
authors.lastname: Kuznetsov
authors.forename: E A
authors.initials: EA
authors.lastname: Suchkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D065570:Gastric Absorption; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D049990:Membrane Transport Modulators / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D051381:Rats; D012996:Solutions; D013607:Tablets
chemical_list: D049990:Membrane Transport Modulators; C581791:RGPU-135; D012996:Solutions; D013607:Tablets; D018698:Glutamic Acid