title: Case Report: Acute Cerebellar Thrombosis in an Adult Patient with IgM Nephropathy.
abstract: IgM nephropathy is a relatively rare cause of idiopathic nephrotic syndrome.1 It was initially described by van de Putte,2 then by Cohen and Bhasin in 1978, as a distinctive feature of mesangial proliferative glomerulonephritis.2 It is typically characterized by diffuse IgM deposits on the glomeruli and diffuse mesangial hypercellularity. Little is known about the pathogenesis and treatment of this disease.1,3 We describe a patient who presented with nonspecific symptoms of epigastric pain, nausea, and early satiety. Abdominal imaging and endoscopies were unremarkable. She was found to have significant proteinuria (6.4 g/24 hours), hyperlipidemia, and edema consistent with a diagnosis of nephrotic syndrome. Kidney biopsy was performed and confirmed an IgM nephropathy. Less than 2 weeks after her diagnosis of IgM nephropathy, she presented with an acute cerebellar stroke. Thrombophilia is a well-known complication of nephrotic syndrome, but a review of the literature failed to show an association between IgM nephropathy and acute central nervous system thrombosis.
authors.affiliation: Houston Methodist Hospital, Houston, Texas.
authors.forename: Abimbola
authors.initials: A
authors.lastname: Adike
authors.affiliation: Houston Methodist Hospital, Houston, Texas.
authors.forename: Mariyam
authors.initials: M
authors.lastname: Cherry
authors.affiliation: Houston Methodist Hospital, Houston, Texas.
authors.forename: Melina
authors.initials: M
authors.lastname: Awar
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002531:Cerebellum / Q000098:blood supply*; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007668:Kidney / Q000276:immunology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011237:Predictive Value of Tests; D012307:Risk Factors; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D015415:Biomarkers; D007075:Immunoglobulin M
keywords: IgM nephropathy; cerebellar thrombosis; thromboembolic events