title: Efficacy of ozonized olive oil in the management of oral lesions and conditions: A clinical trial.
abstract: The oral cavity is an open ecosystem that shows a dynamic balance between the entrance of microorganisms (bacterial, viral or fungal), colonization modalities, nutritional balance, and host defenses against their removal. The oral lesions including aphthous ulcerations, herpes labialis, oral candidiasis, oral lichen planus, and angular cheilitis some of the common entities encountered in the clinical practice. A variety of treatment options is available in the literature for all of these lesions and conditions. Topical ozone therapy is a minimally invasive technique that can be used for these conditions without any side effects.
  
  
  OBJECTIVE
  To evaluate the efficacy of ozonized olive oil in the treatment of oral lesions and conditions.
  
  
  METHODS
  A longitudinal study was carried out on 50 patients (aphthous ulcerations, herpes labialis, oral candidiasis, oral lichen planus, and angular cheilitis). The ozonized olive oil was applied twice daily until the lesion regresses for a maximum of 6 months.
  
  
  RESULTS
  All the lesions regress in patients with aphthous ulcerations, herpes labialis, oral candidiasis and angular cheilitis or showed improvement in the signs and symptoms in oral lichen planus patients. No toxicity or side effect was observed in any of the patients.
  
  
  CONCLUSIONS
  Ozone therapy though requires a gaseous form to be more effective, but topical form can also bring out the positive results without any toxicity or side effect. Hence, it can be considered as a minimally invasive therapy for the oral infective and immunological conditions.
authors.affiliation: Department of Oral Medicine and Radiology, Yamuna Institute of Dental Science and Research, Yamuna Nagar, Haryana, India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Kumar
authors.affiliation: Department of Prosthodontics, Yamuna Institute of Dental Science and Research, Yamuna Nagar, Haryana, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Arora
authors.affiliation: Department of Oral Medicine and Radiology, Swami Devi Dyal Hospital and Dental College, Barwala, Haryana, India.
authors.forename: Gagan
authors.initials: G
authors.lastname: Puri
authors.affiliation: Department of Oral Medicine and Radiology, Swami Devi Dyal Hospital and Dental College, Barwala, Haryana, India.
authors.forename: Konidena
authors.initials: K
authors.lastname: Aravinda
authors.affiliation: Department of Oral Medicine and Radiology, Swami Devi Dyal Hospital and Dental College, Barwala, Haryana, India.
authors.forename: Avani
authors.initials: A
authors.lastname: Dixit
authors.affiliation: Department of Oral Medicine and Radiology, Swami Devi Dyal Hospital and Dental College, Barwala, Haryana, India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Jatti
keywords: Conditions; oral mucosal lesions; ozone therapy; topical O3