title: The efficacy of diffusion weighted imaging and apparent diffusion coefficients mapping for liver metastasis of colonic adenocarcinomas.
abstract: OBJECTIVE
  To establish retrospectively the relation between the histopathologic grade of colorectal liver metastasis and apparent diffusion coefficient (ADC) values of hepatic metastases of colorectal adenocarcinomas.
  
  
  METHODS
  The diagnoses of liver metastases were confirmed with biopsy, surgery, and follow-up imaging findings. Twenty-six patients with 94 liver metastasis were included in the study. Of 94 masses, 59 were poorly-differentiated adenocarcinoma, 18 were moderately-differentiated adenocarcinoma, and 17 were well-differentiated regarding the diameters, ADC values, and ratio index (RI) values. Kolmogorov-Smirnov normality test, Kruskal-Wallis analysis of variance, Mann-Whitney U test with Bonferroni correction, Spearman correlation analysis, and receiver operating characteristics curve methods were applied to evaluate the statistical relations.
  
  
  RESULTS
  There was a statistically significant difference in terms of ADC values and RI between poorly-differentiated adenocarcinoma and moderately-differentiated adenocarcinoma plus well-differentiated adenocarcinomas. Poorly-differentiated adenocarcinomas have the lowest ADC values and highest RI values among other groups.
  
  
  CONCLUSIONS
  Use of ADC values alone can be executed for the diagnosis of focal hepatic masses and also can aid in the differentiation of benign and malignant hepatic lesions.
authors.affiliation: Radiology Department, Education and Research Hospital, Ankara, Turkey. E-mail. melikem_3@yahoo.com.
authors.forename: Melike R
authors.initials: MR
authors.lastname: Metin
authors.forename: Hasan
authors.initials: H
authors.lastname: Aydın
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Çetin
authors.forename: Evrim
authors.initials: E
authors.lastname: Özmen
authors.forename: Serra
authors.initials: S
authors.lastname: Kayaçetin
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000556:secondary; D000368:Aged; D003110:Colonic Neoplasms / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012189:Retrospective Studies