title: Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study.
abstract: OBJECTIVE
  To determine radiographic hand osteoarthritis (HOA) prevalence in patients with HIV-1 infection in comparison with the general population and to address whether metabolic syndrome (MetS) may increase the risk of HOA during HIV-1 infection.
  
  
  METHODS
  Patients with HIV-1 infection and MetS (International Diabetes Federation, IDF criteria) aged 45-65 years were matched by age and gender to HIV-1-infected subjects without MetS and underwent hand radiographs. Framingham OA cohort was used as general population cohort.
  
  
  METHODS
  Radiographic HOA was defined as Kellgren-Lawrence (KL) score ≥2 on more than one joint. Radiographic severity was assessed by global KL score and number of OA joints. HOA prevalence was compared with that found in the Framingham study, stratified by age and sex. Logistic and linear regression models were used to determine the risk factors of HOA in patients with HIV-1 infection.
  
  
  RESULTS
  301 patients (88% male, mean age 53.4±5.0 years) were included, 152 with MetS and 149 without it. Overall, HOA prevalence was 55.5% and was higher for those with MetS than those without it (64.5% vs 46.3%, p=0.002). When considering men within each age group, HOA frequency was greater in patients with HIV-1 infection than the general population (all ages: 55.8% vs 38.7%; p<0.0001), due to the subgroup with MetS (64.9%; p<0.0001), as well as the subgroup without MetS, although not significant (46.6%; p=0.09). Risk of HOA was increased with MetS (OR 2.23, 95% 95% CI 1.26% to 3.96%) and age (OR 1.18, 95% CI 1.12 to 1.25). HOA severity was greater for patients with MetS than those without. HOA was not associated with previous or current exposure to protease inhibitors or HIV infection-related markers.
  
  
  CONCLUSIONS
  HOA frequency is greater in patients with HIV-1 infection, especially those with MetS, than the general population.
  
  
  BACKGROUND
  NCT02353767.
authors.affiliation: Department of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.|Department of Rheumatology, Henri Mondor Hospital, AP-HP, Créteil, France.
authors.forename: Anne-Laurence
authors.initials: AL
authors.lastname: Tomi
authors.affiliation: Department of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.|Sorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Sellam
authors.affiliation: Sorbonnes Universités, UPMC University Paris 06, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.|Department of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Lacombe
authors.affiliation: Sorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.|Biochemistry Department, Tenon Hospital, AP-HP, Sorbonnes Universités, UPMC University Paris 06, INSERM UMR_S938, DHU i2B, IHU ICAN, Paris, France.
authors.forename: Soraya
authors.initials: S
authors.lastname: Fellahi
authors.affiliation: Department of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France.
authors.forename: Manuela
authors.initials: M
authors.lastname: Sebire
authors.affiliation: Department of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Rey-Jouvin
authors.affiliation: Department of Radiology, Saint-Antoine Hospital, AP-HP, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Miquel
authors.affiliation: Sorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.|Biochemistry Department, Tenon Hospital, AP-HP, Sorbonnes Universités, UPMC University Paris 06, INSERM UMR_S938, DHU i2B, IHU ICAN, Paris, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bastard
authors.affiliation: Department of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Maheu
authors.affiliation: Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
authors.forename: Ida K
authors.initials: IK
authors.lastname: Haugen
authors.affiliation: Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Felson
authors.affiliation: Sorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.|Biochemistry Department, Tenon Hospital, AP-HP, Sorbonnes Universités, UPMC University Paris 06, INSERM UMR_S938, DHU i2B, IHU ICAN, Paris, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Capeau
authors.affiliation: Sorbonnes Universités, UPMC University Paris 06, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.|Department of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
authors.affiliation: Department of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.|Sorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Berenbaum
authors.affiliation: Department of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Meynard
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1; D050823:Hand Joints / Q000000981:diagnostic imaging* / Q000821:virology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000821:virology; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D011859:Radiography; D012307:Risk Factors
keywords: Hand Osteoarthritis; Infections; Osteoarthritis