title: 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
abstract: Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from single-cell data.
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, 0317, Oslo, Norway.
authors.forename: Monika
authors.initials: M
authors.lastname: Sekelja
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, 0317, Oslo, Norway.
authors.forename: Jonas
authors.initials: J
authors.lastname: Paulsen
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, 0317, Oslo, Norway. philc@medisin.uio.no.
authors.forename: Philippe
authors.initials: P
authors.lastname: Collas
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000737:chemistry* / Q000235:genetics; D059010:Single-Cell Analysis / Q000379:methods*; D062206:Spatial Analysis
chemical_list: D009707:Nucleosomes