title: Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor.
abstract: Sulfur dioxide (SO2) has long been considered a toxic environmental pollutant and byproduct of industrial processing. Recently it has become evident that SO2 may also have regulatory functions in mammalian pulmonary systems. However, the study of these effects has proven to be challenging due to the difficulty in administering SO2 in a reliable manner. In this work, we report the discovery of a new pH-dependent and water-soluble SO2 donor, benzothiazole sulfinate (BTS). We have found BTS to have slow and sustained SO2 release at physiological pH. Additionally, we have explored its vasorelaxation properties as compared to the authentic SO2 gas solutions. The slow release of BTS should make it a useful tool for the study of endogenously generated SO2.
authors.affiliation: Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
authors.forename: Jacob J
authors.initials: JJ
authors.lastname: Day
authors.affiliation: Institute of Environmental Science, Shanxi University , Taiyuan, Shanxi 030006, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
authors.forename: Armando
authors.initials: A
authors.lastname: Pacheco
authors.affiliation: Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.|Institute of Environmental Science, Shanxi University , Taiyuan, Shanxi 030006, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D017208:Rats, Wistar; D012995:Solubility; D013441:Sulfinic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D013458:Sulfur Dioxide / Q000378:metabolism* / Q000494:pharmacology; D013552:Swine; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D052160:Benzothiazoles; D002317:Cardiovascular Agents; D013441:Sulfinic Acids; D014665:Vasodilator Agents; C000622579:benzothiazole-2-sulfinic acid; D013458:Sulfur Dioxide; D009638:Norepinephrine