title: LncRNA H19 functions as a competing endogenous RNA to regulate AQP3 expression by sponging miR-874 in the intestinal barrier.
abstract: Intestinal barrier dysfunction is a significant clinical problem, which develops in a variety of acute or chronic pathological conditions. In a previous study, we found that microRNA-874 (miR-874) suppresses aquaporin-3 (AQP3) expression, which contributes significantly to intestinal barrier dysfunction. Recently, a new regulatory circuit was identified in which RNA can crosstalk with each other by competing for shared miRNA. Here, we show that the human long noncoding RNA (lncRNA) H19 may function as a competing endogenous RNA (ceRNA) to regulate the expression of AQP3 through competition for miR-874, thus playing a significant role in maintaining intestinal barrier function.
authors.affiliation: Division of Gastrointestinal Surgery, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, China.|Division of Gastrointestinal Surgery, Department of General Surgery, The People's Hospital of Tongling City, China.
authors.forename: Zhaoran
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of General Surgery, The Affiliated Hospital of Nantong University, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhi
authors.affiliation: Division of Gastrointestinal Surgery, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, China.|Department of General Surgery, The Affiliated Hospital of Nantong University, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Division of Gastrointestinal Surgery, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Division of Gastrointestinal Surgery, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.affiliation: Division of Gastrointestinal Surgery, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, China.
authors.forename: Zekuan
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000818:Animals; D051400:Aquaporin 3 / Q000235:genetics / Q000378:metabolism*; D018938:Caco-2 Cells; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism
chemical_list: C496027:AQP3 protein, human; C094335:H19 long non-coding RNA; C561946:MIRN874 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D051400:Aquaporin 3
keywords: Intestinal barrier; Long non-coding RNA; MicroRNA