title: Clinicopathological Spectrum Of Gall Bladder Cancer In Kashmir - An Institutional Study.
abstract: Gallbladder cancer is a highly aggressive malignancy that usually presents at an advanced incurable stage. It is the fifth most common gastro-intestinal tumor and leads to approximately 2800 deaths in United States annually. This was a retrospective study carried out in the Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, a 650-bed super speciality hospital in Kashmir valley. We reviewed the histopathological records of all the patients who were diagnosed as carcinoma gallbladder from Dec 2009-Dec 2013. Gross findings and histopathological findings were noted from the departmental archival material and clinical records of the patients including the clinical presentation, laboratory investigations, radiological investigations, pre-operative diagnosis and intra-operative findings, were retrieved from the hospital records. We analyzed 57 cases of carcinoma gallbladder for their clinicopathological features It included 19 males and 37 females. In our study, adenocarcinomas accounted for 87.5% of total carcinomas. Incidentally, all but one patient where gall stones were found, adenocarcinomas were seen. We have 4 patients of squamous cell carcinoma. In our series we have a single case of small cell carcinoma which was positive for neuroendocrine markers. In our study, gall stones were seen only in 8 cases (14%) of the total cases.
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: R
authors.initials: R
authors.lastname: Makhdoomi
authors.affiliation: Department of Hematology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: N
authors.initials: N
authors.lastname: Bashir
authors.affiliation: Department of Pathology, Govt Medical College, Srinagar, Kashmir.
authors.forename: N
authors.initials: N
authors.lastname: Bhat
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: S
authors.initials: S
authors.lastname: Bashir
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: F
authors.initials: F
authors.lastname: Mustafa
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: A
authors.initials: A
authors.lastname: Aiman
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: A
authors.initials: A
authors.lastname: Charaki
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: S
authors.initials: S
authors.lastname: Hussain
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmirr.
authors.forename: S
authors.initials: S
authors.lastname: Shafi
authors.affiliation: Department of Pathology, Govt Medical College, Srinagar, Kashmir.
authors.forename: S
authors.initials: S
authors.lastname: Baht
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: N
authors.initials: N
authors.lastname: Bashir
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: Z
authors.initials: Z
authors.lastname: Zahir
authors.affiliation: Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir.
authors.forename: P
authors.initials: P
authors.lastname: Shah
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D012189:Retrospective Studies