title: [. Role of molecular and genetic factors in survival from uveal melanoma].
abstract: OBJECTIVE
  to analyze survival rates in uveal melanoma (UM) patients and establish correlations with chromosome 3 monosomy, chromosome 1p deletion, and RASSF1A methylation.
  
  
  METHODS
  Methylation-specific PCR analysis was performed in 104 patients with histologically verified UM.
  
  
  RESULTS
  A statistically significant correlation has been found between chromosome 3 monosomy, on the one hand, and mixed/epithelioid cell melanomas and ciliary body involvement, on the other. As for chromosome 1p deletion, it has demonstrated association with extrabulbar tumor growth. We have also calculated 5-year survival and mortality rates in «large» UMs and their relationship with chromosome 3 monosomy, chromosome 1p deletion, and RASSF1A methylation.
  
  
  CONCLUSIONS
  Chromosome 3 monosomy is associated with lower survival rates, while RASSF1A methylation - with a better prognosis. A combination of molecular and genetic changes (particularly, chromosome 3 monosomy and chromosome 1p deletion) also leads to reduced survival in UM patients.
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of Russia, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062; Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya St., Moscow, Russian Federation 127473.
authors.forename: S V
authors.initials: SV
authors.lastname: Saakyan
authors.affiliation: Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya St., Moscow, Russian Federation 127473.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Tsygankov
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of Russia, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
authors.forename: A G
authors.initials: AG
authors.lastname: Amiryan
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of Russia, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
authors.forename: N V
authors.initials: NV
authors.lastname: Sklyarova
authors.affiliation: First Moscow State Medical University, 8/2 Trubetskaya St., Moscow, Russian Federation, 119991.
authors.forename: D V
authors.initials: DV
authors.lastname: Zaletaev