title: [CURRENT OPPORTUNITIES IN THE IDENTIFICATION OF NOVEL MOLECULAR TARGETS FOR PHARMACOLOGICAL CORRECTION OF BLOOD-BRAIN BARRIER PERMEABILITY].
abstract: Review covers current achievements in the methodology of target discovery and validation for the development of drugs restoring structural and functional integrity of the blood-brain barrier (BBB) in cases of brain injury and neuroinflammation. Some new targets (in the context of BBB permeability) are discussed, which are involved in the regulation of signal transduction involving HIF-1, JNK, NF-κB, Rac, 1 etc., expression of tight-junction proteins, and activity of enzymes producing molecules with pro-inflammatory effects in the BBB cells.
authors.forename: A V
authors.initials: AV
authors.lastname: Morgun
authors.forename: V A
authors.initials: VA
authors.lastname: Ruzaeva
authors.forename: E B
authors.initials: EB
authors.lastname: Boitsova
authors.forename: T E
authors.initials: TE
authors.lastname: Taranushenko
authors.forename: G P
authors.initials: GP
authors.lastname: Martynova
authors.forename: A
authors.initials: A
authors.lastname: Tohidpour
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002199:Capillary Permeability / Q000187:drug effects; D005786:Gene Expression Regulation; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D048670:MAP Kinase Kinase 4 / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D015398:Signal Transduction; D062725:Tight Junction Proteins / Q000235:genetics / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D016328:NF-kappa B; D018696:Neuroprotective Agents; C107953:RAC1 protein, human; D062725:Tight Junction Proteins; D048670:MAP Kinase Kinase 4; D020830:rac1 GTP-Binding Protein