title: Hyaluronidase hypersensitivity: A rare complication of peribulbar block.
abstract: Peribulbar block, though safe, can cause serious complications such as globe perforation and peribulbar hemorrhage. Hyaluronidase is an enzyme that is used as an adjuvant in peribulbar anesthesia, and it helps in rapid penetration of the anesthetic agent. Hypersensitivity to hyaluronidase is a rare but potentially sight-threatening complication. We report a case of hyaluronidase hypersensitivity following peribulbar injection for cataract surgery mimicking as peribulbar hematoma in the immediate postinjection phase and as orbital cellulitis 48 h later.
authors.affiliation: Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
authors.forename: A R
authors.initials: AR
authors.lastname: Rajalakshmi
authors.forename: M Ashok
authors.initials: MA
authors.lastname: Kumar
mesh_terms: D019162:Anesthetics, Combined / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage; D002045:Bupivacaine / Q000008:administration & dosage; D002387:Cataract Extraction; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis; D005094:Exophthalmos / Q000139:chemically induced* / Q000175:diagnosis; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000009:adverse effects*; D008012:Lidocaine / Q000008:administration & dosage; D008875:Middle Aged; D009407:Nerve Block / Q000009:adverse effects*; D009915:Orbit / Q000187:drug effects; D019315:Retrobulbar Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D008012:Lidocaine; D006821:Hyaluronoglucosaminidase; D002045:Bupivacaine