title: [Two cases of neonatal meningitis after new gentamicin dosing guidelines].
abstract: Neonates with suspected or proven sepsis are treated with ampicillin and until recently with 5 mg gentamicin/kg every 24 h. New guidelines recommend the same gentamicin dose, but with longer intervals depending on gestational age. Two neonates receiving gentamicin every 48 h improved initially, but both deteriorated again before the second dose. In both infants ampicillin-resistant but gentamicin-sensitive Escherichia coli was found. In one of the infants a resistant/less sensitive E. coli strain was also found in the cerebrospinal fluid. The rationale for the new dosing guidelines is discussed.
authors.affiliation: anneblab@rm.dk.
authors.forename: Anne Sofie
authors.initials: AS
authors.lastname: Blaabjerg
authors.forename: Jesper
authors.initials: J
authors.lastname: Fenger-Grøn
authors.forename: Jens Kjølseth
authors.initials: JK
authors.lastname: Møller
authors.forename: Poul Erik Lund
authors.initials: PE
authors.lastname: Kofoed
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004926:Escherichia coli / Q000302:isolation & purification; D017809:Fatal Outcome; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020814:Meningitis, Escherichia coli / Q000188:drug therapy; D017410:Practice Guidelines as Topic; D018805:Sepsis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins