title: Macrophage Cell Membrane Camouflaged Au Nanoshells for in Vivo Prolonged Circulation Life and Enhanced Cancer Photothermal Therapy.
abstract: Macrophage cell membrane (MPCM)-camouflaged gold nanoshells (AuNS) that can serve as a new generation of photothermal conversion agents for in vivo photothermal cancer therapy are presented. They are constructed by the fusion of biocompatible AuNSs and MPCM vesicles. The resulting MPCM-coated AuNSs exhibited good colloidal stability and kept the original near-infrared (NIR) adsorption of AuNSs. Because AuNS carried high-density coverage of MPCMs, the totally functional portions of macrophage cells membrane were grafted onto the surface of AuNSs. This surface functionalization provided active targeting ability by recognizing tumor endothelium and thus improved tumoritropic accumulation compared to the red blood cell membrane-coating approach. These biomimetic nanoparticles significantly enhance in vivo blood circulation time and local accumulation at the tumor when administered systematically. Upon NIR laser irradiation, local heat generated by the MPCM-coated AuNS achieves high efficiency to suppress tumor growth and selectively ablate cancerous cells within the illuminated zone. Therefore, MPCM-coated AuNSs remained the natural properties of their source cells, which may improve the efficacy of photothermal therapy modulated by AuNSs and other noble-metal nanoparticles.
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Harbin 150080, China.|Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface, and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: Xuan
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Harbin 150080, China.|CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Shao
authors.affiliation: CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Luru
authors.initials: L
authors.lastname: Dai
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface, and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000737:chemistry*; D005434:Flow Cytometry; D006046:Gold / Q000737:chemistry*; D006979:Hyperthermia, Induced; D008264:Macrophages / Q000166:cytology*; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D057145:Nanoshells / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy; D013997:Time Factors
chemical_list: D006046:Gold
keywords: Au nanoshell; biostealth coating; long circulation; macrophage cell membrane; photothermal therapy