title: Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride.
abstract: The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2 , in contrast to claims in the literature that CaCl2 is required for micellization.
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Kirkham
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: Valeria
authors.initials: V
authors.lastname: Castelletto
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK. I.W.Hamley@reading.ac.uk.
authors.forename: Ian William
authors.initials: IW
authors.lastname: Hamley
authors.affiliation: Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0DE, UK.
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0DE, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Rambo
authors.affiliation: Dep. of Applied Physics, Aalto University, PO Box 15100, 00076, Aalto, Finland.
authors.forename: Mehedi
authors.initials: M
authors.lastname: Reza
authors.affiliation: Dep. of Applied Physics, Aalto University, PO Box 15100, 00076, Aalto, Finland.
authors.forename: Janne
authors.initials: J
authors.lastname: Ruokolainen
mesh_terms: D002122:Calcium Chloride / Q000737:chemistry*; D002942:Circular Dichroism; D020285:Cryoelectron Microscopy; D017576:Daptomycin / Q000737:chemistry*; D055666:Lipopeptides / Q000737:chemistry; D008823:Micelles; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000737:chemistry; D053838:Scattering, Small Angle; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D055666:Lipopeptides; D008823:Micelles; D010456:Peptides, Cyclic; D002122:Calcium Chloride; D017576:Daptomycin
keywords: antimicrobial peptides; lipopeptide; micelles; secondary structure; self-assembly