title: DNA Tumor Viruses and Cell Metabolism.
abstract: Viruses play an important role in cancerogenesis. It is estimated that approximately 20% of all cancers are linked to infectious agents. The viral genes modulate the physiological machinery of infected cells that lead to cell transformation and development of cancer. One of the important adoptive responses by the cancer cells is their metabolic change to cope up with continuous requirement of cell survival and proliferation. In this review we will focus on how DNA viruses alter the glucose metabolism of transformed cells. Tumor DNA viruses enhance "aerobic" glycolysis upon virus-induced cell transformation, supporting rapid cell proliferation and showing the Warburg effect. Moreover, viral proteins enhance glucose uptake and controls tumor microenvironment, promoting metastasizing of the tumor cells.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, 17177 Stockholm, Sweden.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Mushtaq
authors.affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, 17177 Stockholm, Sweden.
authors.forename: Suhas
authors.initials: S
authors.lastname: Darekar
authors.affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, 17177 Stockholm, Sweden; R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NASU, Kyiv 03022, Ukraine.
authors.forename: Elena
authors.identifier: 0000-0001-7001-4035
authors.initials: E
authors.lastname: Kashuba
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D002472:Cell Transformation, Viral; D004263:DNA Tumor Viruses / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000378:metabolism* / Q000473:pathology; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D014764:Viral Proteins