title: Uniform and accelerated degradation of pure iron patterned by Pt disc arrays.
abstract: Pure iron has been confirmed as a promising biodegradable metal. However, the degradation rate of pure iron should be accelerated to meet the clinical requirements. In this work, two different designs of platinum disc arrays, including sizes of Φ20 μm × S5 μm and Φ4 μm × S4 μm, have been coated on the surface of pure iron. Corrosion tests showed the platinum discs formed plenty of galvanic cells with the iron matrix which significantly accelerated the degradation of pure iron. Simultaneously, due to the designability of the shape, size as well as distribution of Pt discs, the degradation rate as well as degradation uniformity of pure iron can be effectively controlled by coating with platinum discs. The cytotoxicity test results unveiled that Pt discs patterned pure iron exhibited almost no toxicity to human umbilical vein endothelial cells, but a significant inhibition on proliferation of vascular smooth muscle cells. In addition, the hemolysis rate of Pt discs patterned pure iron was lower than 1%. Moreover, Pt discs also effectively reduced the number of adhered platelets. All these results indicated that Pt discs patterning is an effective way to accelerate degradation and improve biocompatibility of pure iron.
authors.affiliation: State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000633:toxicity; D003343:Corrosion; D004563:Electrochemistry; D006461:Hemolysis / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000633:toxicity; D007552:Isotonic Solutions; D008956:Models, Chemical; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D010984:Platinum / Q000737:chemistry* / Q000633:toxicity; D015607:Stents; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; C072670:Hanks Balanced Salt Solution; D007552:Isotonic Solutions; D010984:Platinum; D007501:Iron