title: Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films.
abstract: Children frequently receive medicines that are designed for adults. The dose of commercially available products is adapted, mostly based on the child's bodyweight, thereby neglecting differences in pharmacokinetic and pharmacodynamics parameters. If commercial products are unsuitable for administration to children or are unavailable, extemporaneous pharmacy preparations are a good alternative. For this particular population, orodispersible films (ODFs) can be a highly attractive dosage form for the oral administration of drugs. ODFs are relatively easy to prepare in a hospital setting, create dose flexibility, and may suit an individual approach, especially for patients having difficulties in swallowing tablets or being fluid restricted. In this article, various aspects related to pharmacy preparations, clinical application, and preparation of ODFs for pediatric patients are highlighted and discussed.
authors.affiliation: Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands. j.c.visser@rug.nl.
authors.forename: J Carolina
authors.initials: JC
authors.lastname: Visser
authors.affiliation: Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
authors.forename: Herman J
authors.initials: HJ
authors.lastname: Woerdenbag
authors.affiliation: Erasmus MC-Sophia Children's Hospital Rotterdam, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
authors.forename: Lidwien M
authors.initials: LM
authors.lastname: Hanff
authors.affiliation: Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
authors.forename: Henderik W
authors.initials: HW
authors.lastname: Frijlink
mesh_terms: D000284:Administration, Oral; D006801:Humans; D010372:Pediatrics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D057285:Precision Medicine; D013607:Tablets / Q000008:administration & dosage*
chemical_list: D004364:Pharmaceutical Preparations; D013607:Tablets
keywords: Clinical possibilities; Extemporaneous pharmacy preparations; Orodispersible films