title: Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity.
abstract: Accumulated evidence demonstrated that Adenosine A2A receptor (A2AR) is involved in the inflammatory diseases. In the present study, we showed that a selective A2AR agonist, CGS21680, exacerbated experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin. The exacerbation was accompanied with reduced CD4(+)Foxp3(+) T cells, increased CD4(+)CXCR5(+) T cells, B cells, dendritic cells and antigen-specific autoantibodies, which is possibly due to the inhibition of IL-2 induced by CGS21680. Combined with previous studies, our data indicate that the effects of A2AR stimulation in vivo are variable in different diseases. Caution should be taken in the use of A2AR agonists.
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Heng
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Central Laboratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Long-Tao
authors.initials: LT
authors.lastname: Yue
authors.affiliation: Department of Neurology, Taian City Central Hospital, Taian 271000, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China. Electronic address: ruisheng_duan@yahoo.com.
authors.forename: Rui-Sheng
authors.initials: RS
authors.lastname: Duan
mesh_terms: D000241:Adenosine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D058908:Adenosine A2 Receptor Agonists / Q000494:pharmacology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002417:Cattle; D016207:Cytokines / Q000378:metabolism*; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D056724:Immunity, Humoral / Q000187:drug effects / Q000502:physiology*; D007074:Immunoglobulin G / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D009186:Myelin Sheath / Q000276:immunology*; D009422:Nervous System Diseases / Q000139:chemically induced; D009444:Neuritis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D010627:Phenethylamines / Q000009:adverse effects / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D043683:Receptors, Adenosine A2 / Q000378:metabolism*; D012584:Sciatic Nerve / Q000473:pathology
chemical_list: D058908:Adenosine A2 Receptor Agonists; D016207:Cytokines; D007074:Immunoglobulin G; D010627:Phenethylamines; D043683:Receptors, Adenosine A2; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D000241:Adenosine
keywords: A(2A) receptor; CGS21680; Experimental autoimmune neuritis