title: The HA-incorporated nanostructure of a peptide-drug amphiphile for targeted anticancer drug delivery.
abstract: A simple peptide based prodrug of camptothecin (CPT) has been synthesised in which the CPT is conjugated to a tripeptide (KCK) via a disulfide linkage (KCK-CPT) and self-assembled into well-defined nanostructures in water depending on the concentration. The hyaluronic acid (HA) complex of KCK-CPT exhibited target specific toxicity with excellent antitumour efficiency.
authors.affiliation: Department of Chemistry, School of Natural Science, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: Huyeon
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Chemistry, School of Natural Science, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: M T
authors.initials: MT
authors.lastname: Jeena
authors.affiliation: Department of Chemistry, School of Natural Science, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: L
authors.initials: L
authors.lastname: Palanikumar
authors.affiliation: Graduate School of Analytical Science and Technology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 305-764, Korea.
authors.forename: Yoojeong
authors.initials: Y
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, School of Natural Science, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: Sooham
authors.initials: S
authors.lastname: Park
authors.affiliation: Graduate School of Analytical Science and Technology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 305-764, Korea.
authors.forename: Eunji
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Chemistry, School of Natural Science, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: Ja-Hyoung
authors.initials: JH
authors.lastname: Ryu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006820:Hyaluronic Acid / Q000737:chemistry*; D018613:Microscopy, Confocal; D049329:Nanostructures; D010455:Peptides / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D006820:Hyaluronic Acid