title: [Blood coagulation function change and influence factors in Cushing's syndrome and obesity].
abstract: OBJECTIVE
  To compare and analysis blood coagulation index change and influence factors in Cushing's syndrome (CS) and obesity (OB) patients to provide theoretical evidence for improving the prognosis of them.
  
  
  METHODS
  A total of 250 patients with CS and 164 patients with obesity were collected from October 2012 to August 2015 in Peking Union Medical College Hospital. Peripheral blood cells, liver and kidney function, blood lipid, 24 h urine free cortisol (24 hUFC) and blood coagulation were tested.
  
  
  RESULTS
  The proportion of patients with abnormal blood coagulation indexes were 80% (200/250) and 52% (85/164) respectively in CS and OB patients.Compared with OB patients, coagulation and fibrinolysis values decreased significantly in CS patients. In addition, the shortening of activated partial thromboplastin time (APTT) was more obvious in CS patients, while 24 hUFC, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were higher than OB. In OB patients, body mass index (BMI), fasting blood-glucose (FBG), TC and LDL-C were associated with blood coagulation abnormalities; in patients with CS, alanine aminotransferase (ALT), aspartate aminotransferase (AST), 24 hUFC, white blood cell (WBC) and platelet (PLT) were associated with blood coagulation abnormalities.
  
  
  CONCLUSIONS
  Higher coagulation state in CS is likely relevant to higher level of TC, LDL and cortisol hydrocortisone which, in return, have impact on the blood coagulation system, therefore, the risk of thrombosis in CS patients is increased.
authors.affiliation: Department of Endocrinology and Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Pan
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhu
authors.forename: Fengying
authors.initials: F
authors.lastname: Gong
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yang
authors.forename: Linjie
authors.initials: L
authors.lastname: Wang
authors.forename: Kan
authors.initials: K
authors.lastname: Deng
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.forename: Ming
authors.initials: M
authors.lastname: Feng
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001777:Blood Coagulation; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003480:Cushing Syndrome / Q000097:blood*; D005342:Fibrinolysis; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008055:Lipids / Q000145:classification; D009765:Obesity / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D006854:Hydrocortisone