title: Social conflict resolution regulated by two dorsal habenular subregions in zebrafish.
abstract: When animals encounter conflict they initiate and escalate aggression to establish and maintain a social hierarchy. The neural mechanisms by which animals resolve fighting behaviors to determine such social hierarchies remain unknown. We identified two subregions of the dorsal habenula (dHb) in zebrafish that antagonistically regulate the outcome of conflict. The losing experience reduced neural transmission in the lateral subregion of dHb (dHbL)-dorsal/intermediate interpeduncular nucleus (d/iIPN) circuit. Silencing of the dHbL or medial subregion of dHb (dHbM) caused a stronger predisposition to lose or win a fight, respectively. These results demonstrate that the dHbL and dHbM comprise a dual control system for conflict resolution of social aggression.
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Ming-Yi
authors.initials: MY
authors.lastname: Chou
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Ryunosuke
authors.initials: R
authors.lastname: Amo
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Masae
authors.initials: M
authors.lastname: Kinoshita
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.
authors.forename: Bor-Wei
authors.initials: BW
authors.lastname: Cherng
authors.affiliation: Laboratory for Neural Computation and Adaptation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shimazaki
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Agetsuma
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Shiraki
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Tazu
authors.initials: T
authors.lastname: Aoki
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Mikako
authors.initials: M
authors.lastname: Takahoko
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Aichi 444-8787, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Higashijima
authors.affiliation: Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan. Laboratory for Molecular Brain Science, Department of Life Science and Medical Bioscience, Waseda University, Tokyo 162-8430, Japan. hitoshi@brain.riken.jp.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okamoto
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D003220:Conflict, Psychological; D019262:Habenula / Q000502:physiology*; D006608:Hierarchy, Social; D066268:Interpeduncular Nucleus / Q000502:physiology; D017008:Negotiating; D009435:Synaptic Transmission; D015027:Zebrafish