title: In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating.
abstract: Novel biomedical titanium (Ti) implants with high osteogenic ability for fast and good osseointegration under normal as well as osteoporotic conditions are urgently needed. Expanding on our previous in vitro results, we hypothesized that nanotubular, strontium-loaded (NT-Sr) structures on Ti implants would have favorable osteogenic effects and evaluated the in vivo osseointegration of these implants in rats. The structures with nanotubes of different diameters were fabricated by electrochemical anodization at 10 and 40 V, and the amounts of Sr loaded were adjusted by using two hydrothermal treatment times of 1 and 3 hours. Qualitative microcomputed tomography in two and three dimensions showed that the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours best supported bone growth in vivo. Histomorphometric examination of osseointegration also showed that more newly formed bone was found at its surface. The bone-implant contact percentage was highest (92.48%±0.76%) at 12 weeks. In conclusion, the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours showed excellent osteogenic properties, making it an attractive option for Ti surface modification with considerable clinical potential.
authors.affiliation: Department of Prosthetic Dentistry, The Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Dang
authors.affiliation: Department of Prosthetic Dentistry, The Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Prosthetic Dentistry, The Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Prosthetic Dentistry, The Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Bei
authors.initials: B
authors.lastname: Chang
authors.affiliation: Department of Prosthetic Dentistry, The Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Tianxiao
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Prosthetic Dentistry, The Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Periodontology, School of Stomatology, State Key Laboratory of Military Stomatology, The Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Lingzhou
authors.initials: L
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D004563:Electrochemistry; D005260:Female; D043942:Nanotubes / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects*; D019736:Prostheses and Implants; D051381:Rats; D013324:Strontium / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D014025:Titanium; D013324:Strontium
keywords: in vivo; osseointegration; strontium; titania nanotubes