title: Prelamina and Lamina Cribrosa in Glaucoma Patients With Unilateral Visual Field Loss.
abstract: OBJECTIVE
  To investigate the characteristics of the prelamina and lamina cribrosa (LC) of both eyes in glaucoma patients with unilateral visual field (VF) defect.
  
  
  METHODS
  Forty-one subjects diagnosed with primary open-angle glaucoma with unilateral VF loss and 41 age-matched healthy control subjects were scanned by swept-source optical coherence tomography (SS-OCT). All eyes were divided into three groups: VF-affected glaucomatous eyes (group A, n = 41), perimetrically unaffected fellow eyes (group B, n = 41), and healthy control eyes (group C, n = 41). The anterior prelaminar depth (APLD) and LC depth (LCD) were measured at the center of the reference line (the Bruch's membrane opening plane). The prelaminar tissue thickness (PTT) was obtained by subtracting the APLD from the LCD. The APLD, LCD, and PTT were compared among these groups.
  
  
  RESULTS
  The APLD and LCD were significantly greater in group A than in the other groups (group B, P < 0.001; group C, P < 0.001).The prelaminar tissue was significantly thinner in group A than in the other groups (group B, P = 0.007; group C, P < 0.001). Also, the prelaminar tissue was significantly thinner in group B than in group C (P = 0.003). Multivariate analysis demonstrated a significant association between PTT and initial IOP among the overall study population (P < 0.05).
  
  
  CONCLUSIONS
  In the fellow eyes with unilateral glaucoma patients, APLD was significantly greater, and the prelaminar tissue was significantly thinner, than in the healthy control eyes. Our findings suggest that subclinical or preperimetric changes of the LC and/or prelaminar tissue are already present in the fellow eyes with unilateral glaucoma.
authors.affiliation: Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea 2Department of Ophthalmology, Kyungpook National University Hospital, Daegu, Korea.
authors.forename: Dai Woo
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea 4Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Jeoung
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea 4Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Yong Woo
authors.initials: YW
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore 6Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
authors.forename: Michael J A
authors.initials: MJ
authors.lastname: Girard
authors.affiliation: University of French Polynesia, Tahiti, French Polynesia.
authors.forename: Jean Martial
authors.initials: JM
authors.lastname: Mari
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea 4Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Young Kook
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea 4Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea 4Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Kim
mesh_terms: D042241:Early Diagnosis; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests; D014794:Visual Fields