title: [Understanding the reasons behind the low utilization of thrombolysis in hyperacute ischemic stroke].
abstract: OBJECTIVE
  The study aimed to analyze the influencing factors of thrombolysis therapy in acute ischemic stroke patients with onset time less than 4.5 hours.
  
  
  METHODS
  We consecutively prospectively screened acute ischemic stroke patients with onset time less than 4.5 hours from emergency department, outpatients and inpatients of neurology department, and image center in our hospital over a 31-month time period (April 2012-November 2014). The rate of thrombolysis and the reasons for not receiving thrombolysis were analyzed.
  
  
  RESULTS
  A total of 538 patients who met the inclusion criteria were included (68.2% males, mean age 67±13 years old). Only 104 (19.3%) patients received thrombolysis. The main reasons for the patients not receiving thrombolysis included minor symptoms (172 cases, 39.6%), rapidly improving symptoms and high possibility of transient ischemic attack (TIA) (59 cases, 13.6%), patients or families refusing thrombolysis (44, 10.1%), in-hospital delay (38, 8.8%), elderly people with age over than 80 years old (38, 8.8%).
  
  
  CONCLUSIONS
  The thrombolysis rate within time window of acute ischemic stroke is remarkably higher than that of several years ago in China. The main reasons for not receiving thrombolysis are minor and rapidly improving symptoms, patients or families' refusal, in-hospital delay, elderly people with age over than 80 years old.
authors.affiliation: Department of Neurology, Baotou Central Hospital, Baotou 014040, China.
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Zhang
authors.forename: Jingfen
authors.initials: J
authors.lastname: Zhang
authors.forename: Ruiming
authors.initials: R
authors.lastname: Li
authors.forename: Guojuan
authors.initials: G
authors.lastname: Cheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy*; D002681:China; D004636:Emergency Service, Hospital; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D002546:Ischemic Attack, Transient; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000706:statistics & numerical data*
chemical_list: D005343:Fibrinolytic Agents