title: Impact of Iodinated Contrast on Renal Function and Hemodynamics in Rats with Chronic Hyperglycemia and Chronic Kidney Disease.
abstract: Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact of iodinated contrast on the renal function and hemodynamics in rats with chronic hyperglycemia and chronic kidney disease. A total of 30 rats were divided into six groups; Sham: control of chronic renal disease; Citrate: control of chronic hyperglycemia (CH); Nx5/6: rats with 5/6 nephrectomy; Chronic Hyperglycemia: rats receiving Streptozotocin 65 mg/kg; Nx5/6 + IC: rats Nx5/6 received 6 mL/kg of IC; CH + IC: Chronic hyperglycemia rats receiving 6 mL/kg of IC. Renal function (inulin clearance; urinary neutrophil gelatinase-associated lipocalin, NGAL) and hemodynamics (arterial blood pressure; renal blood flow; renal vascular resistance) were evaluated. Iodinated contrast significantly increased urinary NGAL and reduced inulin clearance, while the hemodynamics parameters showed changes in arterial blood pressure, renal blood flow, and renal vascular resistance in both CKD and CH groups. The results suggest that the iodinated contrast in risk factors models has important impact on renal function and hemodynamics. NGAL was confirmed to play a role of highlight in diagnosis of CI-AKI.
authors.affiliation: Experimentation Laboratory in Animal Model, School of Nursing, University of São Paulo, São Paulo, Brazil.
authors.forename: Sheila Marques
authors.initials: SM
authors.lastname: Fernandes
authors.affiliation: Experimentation Laboratory in Animal Model, School of Nursing, University of São Paulo, São Paulo, Brazil.
authors.forename: Daniel Malisani
authors.initials: DM
authors.lastname: Martins
authors.affiliation: Experimentation Laboratory in Animal Model, School of Nursing, University of São Paulo, São Paulo, Brazil.
authors.forename: Cassiane Dezoti
authors.initials: CD
authors.lastname: da Fonseca
authors.affiliation: Experimentation Laboratory in Animal Model, School of Nursing, University of São Paulo, São Paulo, Brazil.
authors.forename: Mirian
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Experimentation Laboratory in Animal Model, School of Nursing, University of São Paulo, São Paulo, Brazil; Department Medical-Surgical Nursing, School of Nursing, University of São Paulo, São Paulo, Brazil.
authors.forename: Maria de Fátima Fernandes
authors.initials: Mde F
authors.lastname: Vattimo
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000009:adverse effects* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D007444:Inulin / Q000097:blood; D007455:Iodine / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D009392:Nephrectomy; D051381:Rats; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D003287:Contrast Media; D007444:Inulin; D007455:Iodine