title: Cytotoxic pimarane-type diterpenes from the marine sediment-derived fungus Eutypella sp. FS46.
abstract: Two new pimarane-type diterpenes, scopararanes H-I (1-2), along with five known ones (3-7) were isolated from the culture broth of a marine sediment-derived fungus Eutypella sp. FS46, which was obtained from the South China Sea. Their structures were established by extensive spectroscopic analysis. All of them were evaluated for their cytotoxic activities against MCF-7, NCI-H460 and SF-268 tumour cell lines. Scopararane I (2) showed moderate inhibitory activities.
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Saini
authors.initials: S
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Tan
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Zhanghua
authors.initials: Z
authors.lastname: Sun
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Qingling
authors.initials: Q
authors.lastname: Pan
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ye
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Haohua
authors.initials: H
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhang
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology*; D006801:Humans; D013098:Xylariales / Q000378:metabolism*
chemical_list: D045784:Abietanes; D000970:Antineoplastic Agents; C433018:pimarane
keywords: Eutypella sp. FS46; cytotoxic activity; pimarane diterpenes; scopararane H; scopararane I