title: Oral physiology, nutrition and quality of life in diabetic patients associated or not with hypertension and beta-blockers therapy.
abstract: The relationship between type 2 diabetes oral physiology, nutritional intake and quality of life has not been fully elucidated. We assessed the impact of type 2 diabetes - exclusive or associated with hypertension with beta-blockers treatment - on oral physiology, mastication, nutrition and quality of life. This cross-sectional study was performed with 78 complete dentate subjects (15 natural teeth and six masticatory units minimum; without removable or fixed prostheses), divided into three groups: diabetics (DM) (n = 20; 45·4 ± 9·5 years), diabetics with hypertension and receiving beta-blockers treatment (DMH) (n = 19; 41·1 ± 5·1 years) and controls (n = 39; 44·5 ± 11·7 years) matched for gender, age and socioeconomic status. Blood glucose, masticatory performance, swallowing threshold, taste, food intake, stimulated and unstimulated salivary flow, pH and buffering capacity of saliva were assessed. Glycemia was higher in DM than in controls (P < 0·01). No differences were observed between DM and controls for nutrition and quality of life. Both stimulated and unstimulated salivary flow rate were lower in DMH (P < 0·01), which also presented the lowest number of teeth and masticatory units (P < 0·0001), and reduction in the number of chewing cycles (P < 0·01). Controls showed lower Decayed Missing Filled Teeth index (DMFT) scores in comparison with DMH (P = 0·021). Masticatory performance and saliva buffering capacity were similar among groups. Exclusive type 2 diabetes did not alter oral physiology, nutrition or quality of life. However, when hypertension and beta-blockers treatment were associated with diabetes, the salivary flow rate, chewing cycles and number of teeth decreased.
authors.affiliation: Department of Health Sciences, Federal University of Lavras, Lavras, Brazil.
authors.forename: L J
authors.initials: LJ
authors.lastname: Pereira
authors.affiliation: Department of Health Sciences, Federal University of Lavras, Lavras, Brazil.
authors.forename: R C
authors.initials: RC
authors.lastname: Foureaux
authors.affiliation: Department of Dentistry, Lavras University Center, Lavras, Brazil.
authors.forename: C V
authors.initials: CV
authors.lastname: Pereira
authors.affiliation: Department of Statistics, University of São Paulo - ESALQ, Piracicaba, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Alves
authors.affiliation: Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors.forename: C H
authors.initials: CH
authors.lastname: Campos
authors.affiliation: Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors.forename: R C M
authors.initials: RC
authors.lastname: Rodrigues Garcia
authors.affiliation: Department of Veterinary Sciences, Federal University of Lavras, Lavras, Brazil.
authors.forename: E F
authors.initials: EF
authors.lastname: Andrade
authors.affiliation: Department of Odontology, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: T M S V
authors.initials: TM
authors.lastname: Gonçalves
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004245:DMF Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D007576:Jaw, Edentulous, Partially / Q000503:physiopathology*; D008297:Male; D008409:Mastication / Q000187:drug effects / Q000502:physiology*; D008875:Middle Aged; D011788:Quality of Life; D012307:Risk Factors; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*; D014987:Xerostomia / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents
keywords: dental physiological phenomena; oral health; saliva