title: [SEARCHING FOR NEW SYNTHETIC DIURETICS].
abstract: This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 µmol/kg from 1st to 7th day and 54 µmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophenyl-O-β-D-glucopyranoside in a dose of 54 µmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.
authors.forename: I V
authors.initials: IV
authors.lastname: Smirnov
authors.forename: T O
authors.initials: TO
authors.lastname: Murashko
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
authors.forename: A O
authors.initials: AO
authors.lastname: Nemtsev
authors.forename: A A
authors.initials: AA
authors.lastname: Bondarev
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
mesh_terms: D000818:Animals; D002414:Cations, Monovalent; D004231:Diuresis / Q000187:drug effects* / Q000502:physiology; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D065570:Gastric Absorption; D005960:Glucosides / Q000138:chemical synthesis / Q000494:pharmacology*; D009596:Nitrophenols / Q000138:chemical synthesis / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine; D014867:Water / Q000378:metabolism
chemical_list: D002414:Cations, Monovalent; D004232:Diuretics; D005960:Glucosides; D009596:Nitrophenols; D014867:Water; C025193:4-nitrophenyl beta-D-glucoside; D012964:Sodium; D011188:Potassium; C024836:4-nitrophenol