title: Cytokeratin19 positive hepatocellular carcinoma is associated with increased peritumoral ductular reaction.
abstract: OBJECTIVE
  Cytokeratin19 positive (CK19+) hepatocellular carcinoma (HCC) is thought to derive from liver progenitor cells (LPC). However, whether peritumoralductular reaction (DR) differs between CK19+ and CK19 negative (CK19-) HCC patients remains unclear.
  
  
  METHODS
  One hundred and twenty HBV-related HCC patients were enrolled in this study. Clinicopathological variables were collected, and immunohistochemistry staining for CK19, proliferating cell nuclear antigen (PCNA), interleukin-6 (IL-6) and β-catenin were performed in tumor and peritumor liver tissues.
  
  
  RESULTS
  CK19+ HCC patients had higher grade of peritumoral DR and proportion of proliferative DR than the CK19- group. The mean number or the proportion of cytoplasmic β-catenin+ DR was higher in the CK19+ group than in the CK19- group. Furthermore, there were more patients with nuclear β-catenin+ peritumoral DR in the CK19+ group as compared to the CK19- group.
  
  
  CONCLUSIONS
  Peritumoral DR was more abundant and proliferative in CK19+ HCC patients, with higher level of nuclear translocation of β-catenin. However, it is unclear whether peritumoral DR is the cause or result of poor prognosis in these patients.
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Mingyi
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Wan
authors.affiliation: Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Lungen
authors.initials: L
authors.lastname: Lu
mesh_terms: D021581:Active Transport, Cell Nucleus; D000328:Adult; D001653:Bile Ducts, Intrahepatic / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D049109:Cell Proliferation; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis; D053539:Keratin-19 / Q000032:analysis*; D008113:Liver Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D015854:Up-Regulation; D051176:beta Catenin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D053539:Keratin-19; D051176:beta Catenin