title: ANTIFUNGAL ACTIVITY OF Cymbopogon nardus (L.) Rendle (CITRONELLA) AGAINST Microsporum canis FROM ANIMALS AND HOME ENVIRONMENT.
abstract: Dermatophytosis is a common zoonosis in urban centers. Dogs and cats have played an important role as its disseminators. Environmental decontamination is essential for the prevention of its propagation to humans and animals. However, sanitizers or disinfectants with antifungal activity, currently available, have high toxicity. The present study evaluated the in vitro effects of an extract of citronella (Cymbopogon nardus) on 31 Microsporum canis isolates from animals and home environments. Susceptibility tests were performed based on document M38-A2 (2008) of the Clinical and Laboratory Standards Institute with modifications for natural products. Although susceptibility variation was observed between the fungus tested, the concentrations that inhibited the growth of 50 and 90% of the microorganisms were low (19.5 and 78 µg/mL, respectively). Thus, this citronella extract showed potent fungistatic and fungicide activities against M. canis isolated from animals and home environments. Therefore, it could be an alternative for dermatophytosis prophylaxis in the home environment.
authors.affiliation: Universidade Estadual de Maringá, Parana, Brazil.
authors.forename: Isis Regina Grenier
authors.initials: IR
authors.lastname: Capoci
authors.affiliation: Universidade Estadual de Maringá, Parana, Brazil.
authors.forename: Michele Milano da
authors.initials: MM
authors.lastname: Cunha
authors.affiliation: Universidade Estadual de Maringá, Parana, Brazil.
authors.forename: Patricia de Souza
authors.initials: Pde S
authors.lastname: Bonfim-Mendonça
authors.affiliation: Universidade Estadual de Maringá, Parana, Brazil.
authors.forename: Luciana Dias
authors.initials: LD
authors.lastname: Ghiraldi-Lopes
authors.affiliation: Universidade Estadual de Maringá, Parana, Brazil.
authors.forename: Lilian Cristiane
authors.initials: LC
authors.lastname: Baeza
authors.affiliation: Universidade Estadual de Maringá, Parana, Brazil.
authors.forename: Erika Seki
authors.initials: ES
authors.lastname: Kioshima
authors.affiliation: Universidade Estadual de Maringá, Parana, Brazil.
authors.forename: Terezinha Inez Estivalet
authors.initials: TI
authors.lastname: Svidzinski
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002415:Cats; D031743:Cymbopogon / Q000737:chemistry*; D004202:Disinfectants / Q000494:pharmacology; D004285:Dogs; D004781:Environmental Exposure / Q000517:prevention & control; D006798:Housing; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D014005:Tinea / Q000517:prevention & control; D015047:Zoonoses
chemical_list: D000935:Antifungal Agents; D004202:Disinfectants; D010936:Plant Extracts