title: β-Glucan exacerbates allergic airway responses to house dust mite allergen.
abstract: β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.
authors.affiliation: Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, University of Aberdeen, Aberdeen, UK.
authors.forename: Sabelo
authors.initials: S
authors.lastname: Hadebe
authors.affiliation: International Centre for Genetic Engineering and Biotechnology and Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, Cape Town, South Africa.
authors.forename: Frank
authors.initials: F
authors.lastname: Kirstein
authors.affiliation: VIB Inflammation Research Center, Laboratory of Immunoregulation and Mucosal Immunology, University Ghent, Ghent, 9000, Belgium.
authors.forename: Kaat
authors.initials: K
authors.lastname: Fierens
authors.affiliation: Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, University of Aberdeen, Aberdeen, UK.
authors.forename: Pierre
authors.initials: P
authors.lastname: Redelinghuys
authors.affiliation: Pathology, Division of Applied Medicine, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
authors.forename: Graeme I
authors.initials: GI
authors.lastname: Murray
authors.affiliation: Department of Surgery and Center for Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Williams
authors.affiliation: VIB Inflammation Research Center, Laboratory of Immunoregulation and Mucosal Immunology, University Ghent, Ghent, 9000, Belgium.|Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Bart N
authors.initials: BN
authors.lastname: Lambrecht
authors.affiliation: International Centre for Genetic Engineering and Biotechnology and Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, Cape Town, South Africa.
authors.forename: Frank
authors.initials: F
authors.lastname: Brombacher
authors.affiliation: Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, University of Aberdeen, Aberdeen, UK. gordon.brown@abdn.ac.uk.|Aberdeen Fungal Group, MRC Centre for Medical Mycology, Infection, Immunity and Inflammation Programme, School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. gordon.brown@abdn.ac.uk.
authors.forename: Gordon D
authors.initials: GD
authors.lastname: Brown
mesh_terms: D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology* / Q000633:toxicity*; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology*; D004357:Drug Synergism; D004781:Environmental Exposure / Q000009:adverse effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009183:Mycotoxins / Q000276:immunology / Q000633:toxicity; D047071:beta-Glucans / Q000276:immunology* / Q000633:toxicity*
chemical_list: D039741:Antigens, Dermatophagoides; D009183:Mycotoxins; D047071:beta-Glucans; C064197:beta-1,6-glucan
keywords: Allergy; Eosinophil; House dust mite; T helper 2; β-glucans