title: Rapid transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia: A rare case report.
abstract: Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature-appearing lymphocytes in blood, bone marrow, lymph nodes, and spleen with a median lymphocyte count of 20-30 × 10(9)/L at the time of diagnosis. In half of the patients, the lymphocyte count doubles over a period of 1-year and cyclic rise up to 50 × 10(9)/L can occur in untreated patients while in others the count may remain stable for years. Based on the cytogenetic and molecular studies, it has been demonstrated that multiple clones may occur in CLL and clonal evolution is a frequent occurrence. The transformation of CLL to a high-grade non-Hodgkin's lymphoma such as diffuse large B cell lymphoma, Hodgkin lymphoma, and prolymphocytic leukemia is well documented. Whereas the transformation of CLL to acute leukemia occurs in <1% cases and this contrasts the almost invariable progression in patients with chronic myeloid leukemia. Here, we report a rare case of a 55-year-old lady, a diagnosed case of CLL transforming into B-cell acute lymphocytic leukemia over a very short interval of 1 week period.
authors.affiliation: Department of Pathology, GGS Medical College and Hospital, Faridkot, Punjab, India.
authors.forename: Manmeet
authors.initials: M
authors.lastname: Kaur
authors.affiliation: Department of Pathology, GGS Medical College and Hospital, Faridkot, Punjab, India.
authors.forename: Sarita
authors.initials: S
authors.lastname: Nibhoria
authors.affiliation: Department of Pathology, GGS Medical College and Hospital, Faridkot, Punjab, India.
authors.forename: Kanwardeep
authors.initials: K
authors.lastname: Tiwana
authors.affiliation: Department of Pathology, GGS Medical College and Hospital, Faridkot, Punjab, India.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Bajaj
authors.affiliation: Department of Pathology, GGS Medical College and Hospital, Faridkot, Punjab, India.
authors.forename: Sahil
authors.initials: S
authors.lastname: Chhabra
keywords: Acute lymphoblastic leukemia; chronic lymphocytic leukemia; prolymphocytic leukemia