title: Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group.
abstract: This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.
authors.affiliation: 1 Integrated BioBank of Luxemburg (IBBL) , Luxembourg, Luxembourg .
authors.forename: Fay
authors.initials: F
authors.lastname: Betsou
authors.affiliation: 2 Biotheque-SML, Division of Genetics and Laboratory Medicine (DMGL), University Hospital of Geneva , Geneva, Switzerland .
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bulla
authors.affiliation: 3 National Biobank of Korea , Cheongju, South Korea .
authors.forename: Sang Yun
authors.initials: SY
authors.lastname: Cho
authors.affiliation: 4 Australian Prostate Cancer Bioresource/Queensland University of Technology , Brisbane, Australia .
authors.forename: Judith
authors.initials: J
authors.lastname: Clements
authors.affiliation: 5 Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute , Rockville, Maryland.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Chuaqui
authors.affiliation: 6 Moffitt Cancer Center, Department of Anatomic Pathology, University of South Florida , Tampa, Florida.
authors.forename: Domenico
authors.initials: D
authors.lastname: Coppola
authors.affiliation: 7 University of California , San Francisco, AIDS Specimen Bank, San Francisco, California.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: De Souza
authors.affiliation: 8 Universitair Ziekenhuis Antwerpen , Edegem, Belgium .
authors.forename: Annemieke
authors.initials: A
authors.lastname: De Wilde
authors.affiliation: 9 University of Alabama at Birmingham , Birmingham, Alabama.
authors.forename: William
authors.initials: W
authors.lastname: Grizzle
authors.affiliation: 10 San Raffaele Rome University-IRCCS San Raffaele Pisana , Rome, Italy .
authors.forename: Fiorella
authors.initials: F
authors.lastname: Guadagni
authors.affiliation: 11 Specimen Solutions, LLC , Tucker, Georgia .
authors.forename: Elaine
authors.initials: E
authors.lastname: Gunter
authors.affiliation: 12 Coriell Institute for Medical Research , Camden, New Jersey.
authors.forename: Stacey
authors.initials: S
authors.lastname: Heil
authors.affiliation: 13 Cancer Research Division, Cancer Council NSW , Woolloomooloo, Australia .
authors.forename: Verity
authors.initials: V
authors.lastname: Hodgkinson
authors.affiliation: 14 Medpace Reference Laboratories , Cincinnati, Ohio.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kessler
authors.affiliation: 15 Universitätsklinikum Jena , Jena, Germany .
authors.forename: Michael
authors.initials: M
authors.lastname: Kiehntopf
authors.affiliation: 16 Department of Pathology, Chung-Ang University College of Medicine , Dongjak-gu, South Korea .
authors.forename: Hee Sung
authors.initials: HS
authors.lastname: Kim
authors.affiliation: 17 Cellular Technology Ltd , Shaker Heights, Ohio.
authors.forename: Iren
authors.initials: I
authors.lastname: Koppandi
authors.affiliation: 18 Precision for Medicine, Inc., Frederick, Maryland.
authors.forename: Katheryn
authors.initials: K
authors.lastname: Shea
authors.affiliation: 19 Houston Methodist Research Institute , Biorepository, Houston, Texas.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Singh
authors.affiliation: 20 American Society for Investigative Pathology , Bethesda, Maryland.
authors.forename: Marc
authors.initials: M
authors.lastname: Sobel
authors.affiliation: 21 Biobank and Biospecimen Science Research, Windber Research Institute , Windber, Pennsylvania.
authors.forename: Stella
authors.initials: S
authors.lastname: Somiari
authors.affiliation: 22 Department of Pathology and Laboratory Medicine, Children's Research Institute, Medical University of South Carolina , Charleston, South Carolina.
authors.forename: Demetri
authors.initials: D
authors.lastname: Spyropoulos
authors.affiliation: 23 Blood Systems Research Institute , San Francisco, California.
authors.forename: Mars
authors.initials: M
authors.lastname: Stone
authors.affiliation: 24 Karolinska Institutet , Stockholm, Sweden .
authors.forename: Gunnel
authors.initials: G
authors.lastname: Tybring
authors.affiliation: 25 University of Illinois Biorepository, Department of Pathology, College of Medicine, University of Illinois at Chicago , Chicago, Illinois.
authors.forename: Klara
authors.initials: K
authors.lastname: Valyi-Nagy
authors.affiliation: 26 Department of Pathology and Cytology, GZA Hospitals , Wilrijk, Belgium .
authors.forename: Gert
authors.initials: G
authors.lastname: Van den Eynden
authors.affiliation: 27 Baylor College of Medicine , Houston, Texas.
authors.forename: Lalita
authors.initials: L
authors.lastname: Wadhwa
mesh_terms: D018070:Biological Specimen Banks; D035843:Biomedical Research / Q000592:standards; D006801:Humans; D009928:Organ Specificity; D011786:Quality Control; D013048:Specimen Handling / Q000592:standards*
keywords: biological fluid; biospecimen; cells; qualification; quality control; tissue