title: Effects of Caloric Restriction with or without Resistance Training in Dynapenic-Overweight and Obese Menopausal Women: A MONET Study.
abstract: OBJECTIVE
  The dynapenic (DYN)-obese phenotype is associated with an impaired metabolic profile. However, there is a lack of evidences regarding the effect of lifestyle interventions on the metabolic profile of individual with dynapenic phenotype. The objective was to investigate the impact of caloric restriction (CR) with or without resistance training (RT) on body composition, metabolic profile and muscle strength in DYN and non-dynapenic (NDYN) overweight and obese menopausal women.
  
  
  METHODS
  109 obese menopausal women (age 57.9 ± 9.0 yrs; BMI 32.1 ± 4.6 kg/m2) were randomized to a 6-month CR intervention with or without a RT program. Participants were categorized as DYN or NDYN based on the lowest tertile of relative muscle strength in our cohort (< 4.86 kg/BMI).
  
  
  METHODS
  Body composition was measured by DXA, body fat distribution by CT scan, glucose homeostasis at fasting state and during an euglycemic-hyperinsulinemic clamp, fasting lipids, resting blood pressure, fasting inflammation markers and maximal muscle strength.
  
  
  RESULTS
  No difference was observed between groups at baseline for body composition and the metabolic profile. Overall, a treatment effect was observed for all variables of body composition and some variables of the metabolic profile (fasting insulin, glucose disposal, triglyceride levels, triglycerides/HDL-Chol ratio and resting diastolic blood pressure) (P between 0.05 and 0.001). No Group X Treatment interaction was observed for variables of body composition and the metabolic profile. However, an interaction was observed for muscle strength; which significantly improved more in the CR+RT NDYN group (all P ≤ 0.05).
  
  
  CONCLUSIONS
  In the present study, dynapenia was not associated with a worse metabolic profile at baseline in overweight and obese menopausal women. DYN and NDYN menopausal women showed similar cardiometabolic benefit from CR or CR+RT interventions. However, our results showed that the addition of RT to CR was more effective in improving maximal strength in DYN and NDYN obese menopausal women.
authors.affiliation: Martin Brochu, Ph.D., Research Centre on Aging,1036 Belvédère Sud, Sherbrooke, Québec, Canada, J1H 4C4, Tel. (819) 780-2220 # 45326, Fax. (819) 829-7141, E-mail. martin.brochu@usherbrooke.ca.
authors.forename: E
authors.initials: E
authors.lastname: Normandin
authors.forename: M
authors.initials: M
authors.lastname: Sénéchal
authors.forename: D
authors.initials: D
authors.lastname: Prud'homme
authors.forename: R
authors.initials: R
authors.lastname: Rabasa-Lhoret
authors.forename: M
authors.initials: M
authors.lastname: Brochu