title: Essential role of ultrastructural examination for spindle cell oncocytoma: Case report of a rare neoplasm and review of the literature.
abstract: Spindle cell oncocytoma (SCO) is an extremely rare neoplasm of the sellar region recognized as a distinct benign histopathological subtype of pituitary tumors in the 2007 World Health Organization classification of tumors of the central nervous system. The morphology of its neoplastic cells (spindle cells and granular eosinophilic cytoplasm) is common to several other lesions so that immunohistochemistry, together with ultrastructural examination, becomes essential in solving this differential diagnosis. Despite being labeled as benign, recurrence is described. Herein, we report a case of SCO in a 77-year-old man and discuss the diagnostic difficulties, ultrastructural aspects, and prognostic factors.
authors.affiliation: a Department of Advanced Biomedical Sciences , University of Naples Federico II , Naples , Italy.
authors.forename: Elia
authors.initials: E
authors.lastname: Guadagno
authors.affiliation: a Department of Advanced Biomedical Sciences , University of Naples Federico II , Naples , Italy.
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Cervasio
authors.affiliation: a Department of Advanced Biomedical Sciences , University of Naples Federico II , Naples , Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Di Somma
authors.affiliation: a Department of Advanced Biomedical Sciences , University of Naples Federico II , Naples , Italy.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Califano
authors.affiliation: a Department of Advanced Biomedical Sciences , University of Naples Federico II , Naples , Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Solari
authors.affiliation: a Department of Advanced Biomedical Sciences , University of Naples Federico II , Naples , Italy.
authors.forename: Marialaura
authors.initials: M
authors.lastname: Del Basso De Caro
mesh_terms: D018249:Adenoma, Oxyphilic / Q000737:chemistry / Q000601:surgery / Q000648:ultrastructure*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000601:surgery / Q000648:ultrastructure*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Oncocytoma; pituitary; spindle cell