title: Antioxidant, antitumor and immunomodulatory activities of water-soluble polysaccharides in Abrus cantoniensis.
abstract: Abrus cantoniensis is a vegetative food in tropical areas of Asia and claimed as folk beverages and soups consumed for cleansing liver toxicants and preventing liver diseases. Polysaccharides (ACP-І and ACP-II) were extracted with hot water from A. cantoniensis, and isolated by DEAE cellulose chromatography. The chemical properties as well as antioxidant, antitumor and immunomodulatory activities of ACP-I and ACP-II were investigated. The results showed that the ACP-I (9.09kDa) contained only glucose and ACP-II (38.45kDa) consisted of rhamnose, arabinose, galactose and glucose. ACP-II exhibited higher oxygen radical absorbance capacity (ORAC) and hydroxyl radical prevention capacity (HRPC) than ACP-I with ORAC values and HRPC values of 53.42±3.32μmol Trolox equiv./g DW and 34.84±5.07μmol Trolox equiv./g DW. Besides, in the wound healing assay, ACP-II exhibited potent migration inhibitory effects on MCF-7 cells. ACP-II could also significantly stimulate the proliferation of splenocytes and thymocytes, and enhanced NO production of peritoneal macrophages. These findings suggest that the polysaccharide ACP-II in A. cantoniensis could be served as a novel potential functional food.
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Wu
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Fu
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: You
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Arshad Mehmood
authors.initials: AM
authors.lastname: Abbasi
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address: femenghc@scut.edu.cn.
authors.forename: Hecheng
authors.initials: H
authors.lastname: Meng
authors.affiliation: School of Applied Chemistry and Biological Technology, Shenzhen Polytechnic, Shenzhen 518055, China. Electronic address: liudongszpt@163.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan.
authors.forename: Rana Muhammad
authors.initials: RM
authors.lastname: Aadil
mesh_terms: D029912:Abrus / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000737:chemistry; D061986:MCF-7 Cells; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D007155:Immunologic Factors; D010936:Plant Extracts
keywords: Abrus cantoniensis; Antitumor; Immunomodulatory; Polysaccharides