title: [Drug-induced Pulmonary Hypertension - a Current Review].
abstract: BACKGROUND
  The current classification of pulmonary Hypertension (PH) consists of five clinical groups, and drug-induced pulmonary arterial hypertension (PAH) is classified under Group 1 as a distinct entity. Our present work encompasses the available data concerning the association between the intake of a wide range of drugs and development of PAH.
  
  
  METHODS
  A selective literature search was performed in Pubmed to include published work between the years 1960 - 2015. For this search, the terms pulmonary hypertension, pulmonary arterial hypertension, pulmonary veno-occlusive disease, drug induced pulmonary hypertension and chemotherapy induced PVOD were used. Mainly German, English and French publications regarding this topic were considered.
  
  
  RESULTS
  An association between drug intake and PH development was described for different medications, among them appetite-suppressant drugs, interferon alpha and beta, but also several chemotherapeutic drugs.
  
  
  CONCLUSIONS
  The present literature regarding drug-induced PH mainly comprises case reports and small patient cohorts. Drug-induced PH has become increasingly discussed in recent years and needs further elucidation. A close cooperation between clinicians, PH expert centers and regulatory agencies is mandatory to identify other potential drugs at an early stage that may be linked to PH development. For the clinician, a thorough patient interview including drug history is necessary in the evaluation of a patient with PH.
authors.affiliation: Univ. Paris-Sud, Faculté de Médecine, Le Kremlin Bicêtre, Frankreich.
authors.forename: S
authors.initials: S
authors.lastname: Günther
authors.affiliation: Medizinische Klinik und Poliklinik V, Klinikum der Ludwig-Maximilians-Universität München und Asklepios Fachkliniken München Gauting.
authors.forename: J
authors.initials: J
authors.lastname: Behr
authors.affiliation: Medizinische Klinik III - Pneumologie, Allergologie, Schlaf- und Beatmungsmedizin, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Universitätsklinikum der Ruhr-Universität Bochum (UK RUB).
authors.forename: H
authors.initials: H
authors.lastname: Knoop
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001067:Appetite Depressants / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control*; D061214:Patient Safety; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D001067:Appetite Depressants; D017367:Selective Serotonin Reuptake Inhibitors