title: Probiotics, prebiotics and colorectal cancer prevention.
abstract: Colorectal cancer (CRC), the third major cause of mortality among various cancer types in United States, has been increasing in developing countries due to varying diet and dietary habits and occupational hazards. Recent evidences showed that composition of gut microbiota could be associated with the development of CRC and other gut dysbiosis. Modulation of gut microbiota by probiotics and prebiotics, either alone or in combination could positively influence the cross-talk between immune system and microbiota, would be beneficial in preventing inflammation and CRC. In this review, role of probiotics and prebiotics in the prevention of CRC has been discussed. Various epidemiological and experimental studies, specifically gut microbiome research has effectively improved the understanding about the role of probiotics and microbial treatment as anticarcinogenic agents. A few human studies support the beneficial effect of probiotics and prebiotics; hence, comprehensive understanding is urgent to realize the clinical applications of probiotics and prebiotics in CRC prevention.
authors.affiliation: Department of Biotechnology, Christ College, Rajkot, India. Electronic address: Padma_ambalam@yahoo.com.
authors.forename: Padma
authors.initials: P
authors.lastname: Ambalam
authors.affiliation: Bioengineering and Drug Design Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences and Bioengineering, Indian Institute of Technology, Chennai, India.
authors.forename: Maya
authors.initials: M
authors.lastname: Raman
authors.affiliation: School of Biotechnology, Chemical Building, East Campus, NIT Calicut, Calicut, India.
authors.forename: Ravi Kiran
authors.initials: RK
authors.lastname: Purama
authors.affiliation: Bioengineering and Drug Design Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences and Bioengineering, Indian Institute of Technology, Chennai, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Doble
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D004032:Diet; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology; D056692:Prebiotics / Q000382:microbiology*; D019936:Probiotics / Q000627:therapeutic use*
chemical_list: D016588:Anticarcinogenic Agents; D056692:Prebiotics
keywords: Bifidobacteria; Colorectal cancer; Gut microbiota; Lactobacillus; Prebiotics; Probiotics; Synbiotics