title: Meningioma consistency prediction utilizing tumor to cerebellar peduncle intensity on T2-weighted magnetic resonance imaging sequences: TCTI ratio.
abstract: OBJECTIVE Meningioma consistency, firmness or softness as it relates to resectability, affects the difficulty of surgery and, to some degree, the extent of resection. Preoperative knowledge of tumor consistency would affect preoperative planning and instrumentation. Several methods of prediction have been proposed, but the majority lack objectivity and reproducibility or generalizability to other surgeons. In a previous pilot study of 20 patients the authors proposed a new method of prediction based on tumor/cerebellar peduncle T2-weighted imaging intensity (TCTI) ratios in comparison with objective intraoperative findings. In the present study they sought validation of this method. METHODS Magnetic resonance images from 100 consecutive patients undergoing craniotomy for meningioma resection were evaluated preoperatively. During surgery a consistency grade was prospectively applied to lesions by the operating surgeon, as determined by suction and/or cavitron ultrasonic surgical aspirator (CUSA) intensity. Consistency grades were A, soft; B, intermediate; and C, fibrous. Using T2-weighted MRI sequences, TCTI ratios were calculated. Analysis of the TCTI ratios and intraoperative tumor consistency was completed with ANOVA and receiver operating characteristic curves. RESULTS Of the 100 tumors evaluated, 50 were classified as soft, 29 as intermediate, and 21 as firm. The median TCTI ratio for firm tumors was 0.88; for intermediate tumors, 1.5; and for soft tumors, 1.84. One-way ANOVA comparing TCTI ratios for these groups was statistically significant (p < 0.0001). A single cutoff TCTI value of 1.41 for soft versus firm tumors was found to be 81.9% sensitive and 84.8% specific. CONCLUSIONS The authors propose this T2-based method of tumor consistency prediction with correlation to objective intraoperative consistency. This method is quantifiable and reproducible, which expands its usability. Additionally, it places tumor consistency on a graded continuum in a clinically meaningful way that could affect preoperative surgical planning.
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Smith
authors.affiliation: Radiology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: John D
authors.initials: JD
authors.lastname: Leever
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Hylton
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Camarata
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Roukoz B
authors.initials: RB
authors.lastname: Chamoun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D002531:Cerebellum / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted
keywords: CUSA = cavitron ultrasonic surgical aspirator; PD = proton density; ROC = receiver operating characteristic; ROI = region of interest; TCTI = tumor to cerebellar peduncle T2-weighted imaging intensity; meningioma; oncology; tumor consistency; ultrasonic aspirator