title: Effect of fermented soybean products intake on the overall immune safety and function in mice.
abstract: Various functional activities have been reported for the fermented soybean productsdoenjang(DJ) andcheonggukjang(CGJ), although no systemic investigations of their immune functions have been conducted to date. We examined the effects of an experimental diet of DJ, CGJ, or a mixture of unfermented raw material for 4 weeks on overall immunity and immune safety in mice. No significant alterations were observed in peripheral or splenic immune cells among groups. Enhanced splenic natural killer cell activity was observed in the DJ and CGJ groups compared with the plain diet group. T helper type-1 (Th1)-mediated immune responses were enhanced in the DJ and CGJ groups with an upregulated production ratio of IFN-γvs. IL-4 and IgG2avs. IgG1 in stimulated splenic T and B cells, respectively. Resistance toListeria monocytogenesinfection was observed in the DJ and CGJ groups. Overall, the results of this study suggest that DJ and CGJ intake consolidates humoral and cellular immunity to Th1 responses.
authors.affiliation: Department of Occupational Health, Catholic University of Daegu, Gyeongsan 38430, Korea.
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Foods Research Institute, CJ CheilJedang Corp., Suwon 16495, Korea.
authors.forename: Se Hee
authors.initials: SH
authors.lastname: Paek
authors.affiliation: Foods Research Institute, CJ CheilJedang Corp., Suwon 16495, Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Shin
authors.affiliation: Foods Research Institute, CJ CheilJedang Corp., Suwon 16495, Korea.
authors.forename: Seung Yeon
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Foods Research Institute, CJ CheilJedang Corp., Suwon 16495, Korea.
authors.forename: Byoung Seok
authors.initials: BS
authors.lastname: Moon
authors.affiliation: Department of Occupational Health, Catholic University of Daegu, Gyeongsan 38430, Korea.
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Park
authors.affiliation: Department of Occupational Health, Catholic University of Daegu, Gyeongsan 38430, Korea.
authors.forename: Gyeong Dong
authors.initials: GD
authors.lastname: Lim
authors.affiliation: Department of Occupational Health, Catholic University of Daegu, Gyeongsan 38430, Korea.
authors.forename: Chang Yul
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Department of Occupational Health, Catholic University of Daegu, Gyeongsan 38430, Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Heo
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D004032:Diet; D005285:Fermentation; D007113:Immunity, Innate; D008088:Listeriosis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D008297:Male; D051379:Mice / Q000276:immunology* / Q000378:metabolism; D008807:Mice, Inbred BALB C; D012376:Rodent Diseases / Q000276:immunology* / Q000382:microbiology; D013025:Glycine max / Q000378:metabolism*
keywords: cheonggukjang; doenjang; immunity; mice; soybean products