title: Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neck.
abstract: This review article describes the potential role of ectonucleotidase activity, adenosine metabolism, and the adenosinergic signaling pathway in the suppression of the host immune system in patients with head and neck cancer. Identifying such mechanisms leads to a better understanding of immunosuppressive mechanisms in this patient population. Further, potential targets for immunotherapy in an adjuvant approach to treating squamous cell carcinoma of the head and neck in the future might be identified and improve the prognosis of these patients.
authors.affiliation: Klinik für Hals-Nasen-Ohrenheilkunde, Kopf-Hals-Chirurgie, Philipps-Universität Marburg, Baldingerstrasse 1, 35043, Marburg, Deutschland. mandapat@med.uni-marburg.de.|Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center New York, New York City, USA. mandapat@med.uni-marburg.de.
authors.forename: M
authors.initials: M
authors.lastname: Mandapathil
mesh_terms: D000241:Adenosine / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D002470:Cell Survival / Q000276:immunology; D006258:Head and Neck Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D056747:Immunomodulation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000276:immunology*; D018448:Models, Immunological; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D007166:Immunosuppressive Agents; D000241:Adenosine
keywords: Adenosine; Head and neck cancer; Immunotherapy; Regulatory T cells; Signaling pathways