title: Protective effect of rosemary on acrylamide motor neurotoxicity in spinal cord of rat offspring: postnatal follow-up study.
abstract: The direct interactive effects of rosemary and acrylamide on the development of motor neurons in the spinal cord remains unknown. Our goal is to confirm the protective effects of rosemary against motor neuronal degeneration induced by acrylamide in the developing postnatal rat spinal cord using a postnatal rat model. We assigned the offspring of treated female rats into control, rosemary; acrylamide group; and recovery groups. This work depended on clinical, histopathological, morphometrically, immunohistochemical and genetic methods. In the acrylamide group, we observed oxidation, motor neuron degeneration, apoptosis, myelin degeneration, neurofilament reduction, reactive gliosis. Whoever, concomitant rosemary intake and withdrawal of acrylamide modulate these effects. These findings proof that dietary rosemary can directly protect motor neuron against acrylamide toxicity in the mammalian developing spinal cord.
authors.affiliation: Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt.
authors.forename: Marwa A
authors.initials: MA
authors.lastname: Al-Gholam
authors.affiliation: Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt.
authors.forename: Hanaa Zakaria
authors.initials: HZ
authors.lastname: Nooh
authors.affiliation: Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt.
authors.forename: Abeer E
authors.initials: AE
authors.lastname: El-Mehi
authors.affiliation: Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt.
authors.forename: Abd El-Moneum
authors.initials: Ael-M
authors.lastname: El-Barbary
authors.affiliation: Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt.
authors.forename: Ahmed Zo El
authors.initials: AZ
authors.lastname: Fokar
keywords: Acrylamide; Development; Motor neuron; Rosemary; Spinal cord