title: [Tanakan as a multimodal cytoprotective factor in general medicine].
abstract: The first section of the review provides recent results regarding the mechanism of the action of a standardized extract of ginkgo biloba leaves EGb761 (tanakan), its effects on apoptosis, neuroplasticity, hemorheology, inhibition of the amyloid genesis and inflammatory response it cause, activation of proteasomes in conformational diseases. Current experimental and clinical results suggest that EGb761 (tanakan) is a high-effective cytoprotective agent in cognitive disorders of various genesis, cardiovascular diseases (in the process of rehabilitation and as a medicine capable to reduce the volume of brain damage in stroke). The effect of tanakan on anxiety and depression in patients with cognitive impairment should be considered as clinically significant.
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Naprienko
authors.affiliation: Kazan State Medical Academy, Kazan; Kazan Federal University, Kazan, Russia.
authors.forename: R G
authors.initials: RG
authors.lastname: Esin
authors.affiliation: Kazan Federal University, Kazan, Russia.
authors.forename: E R
authors.initials: ER
authors.lastname: Mukhametova
authors.affiliation: Kazan Federal University, Kazan, Russia.
authors.forename: O R
authors.initials: OR
authors.lastname: Esin
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: L V
authors.initials: LV
authors.lastname: Smekalkina
mesh_terms: D001007:Anxiety / Q000188:drug therapy; D017209:Apoptosis / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000523:psychology; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy* / Q000523:psychology; D019610:Cytoprotection; D003863:Depression / Q000188:drug therapy; D020441:Ginkgo biloba; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D000096983:Ginkgo Extract
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract