title: Treatment of cancerous ascites and radical gastrectomy with intraperitoneal hyperthermic double-distilled water and cis-diaminodichloro-platinum perfusion.
abstract: OBJECTIVE
  To study the therapeutic effect of intraperitoneal hyperthermic double-distilled water and cis-diaminodichloro-platinum (DDP) perfusion for cancerous ascites and radical gastrectomy.
  
  
  METHODS
  LACA mice were injected peritoneally with H22 cancer cells (2 × 10(7) tumor cells). Five days later, the mice received treatments with either intraperitoneal perfusion of 37 °C isotonic fluid (group I), or 43 °C simple hyperthermic double-distilled water (group II), isotonic fluid (group III), DDP (group IV) or a combination of the hyperthermic double-distilled water with DDP (group V). A clinical experiment with intraperitoneal hyperthermic double-distilled water perfusion with DDP was carried out from September 1991 through September 1993 with 32 advanced gastric cancer patients who had undergone radical gastrectomy.
  
  
  RESULTS
  In comparison with the untreated control group of cancer cell-bearing LACA mice, the mice in all treatment groups showed near complete obliteration of cancer cells in the peritoneal cavity, markedly reduced ascites, prolonged survival times, and reduced growth of peritoneal cancerous nodes. In the clinical experiment, all 32 patients with advanced carcinoma had achieved satisfactory results at the 1-year follow-up, but had unsatisfactory results at the 2-year follow-up.
  
  
  CONCLUSIONS
  The intraperitoneal hyperthermic double-distilled water perfusion with DDP inhibited the occurrence of ascites in LACA mice bearing cancer cells, and prolonged the lifetime of patients with gastric cancer who had undergone radical gastrectomy.
authors.affiliation: Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Chen
authors.affiliation: Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China.
authors.forename: J P
authors.initials: JP
authors.lastname: Chen
authors.affiliation: Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China.
authors.forename: D S
authors.initials: DS
authors.lastname: Peng
authors.affiliation: Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Zhen
authors.affiliation: Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Tan
keywords: Ascites; Cis-diaminodichloro-platinum; Gastrectomy; Perfusion; Stomach neoplasms