title: Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients.
abstract: OBJECTIVE
  Increased levels of high-sensitivity C-reactive protein (hs-CRP) likely leads to the development of atherosclerosis. Therefore, it is very important to know which factors largely influence hs-CRP levels. In the present study, we examined the influence of various atherosclerosis-related factors on hs-CRP levels in patients with type 2 diabetes.
  
  
  METHODS
  A total of 275 patients (176 men, 99 women) were enrolled in this study. We tested the relationship between the number of risk factors reaching a desired value and hs-CRP levels. The Mann-Whitney U-test was used to compare two groups. The Kruskal-Wallis test was used to carry out overall group comparisons, and the Steel-Dwass test was used to carry out between-group comparisons. Spearman's rank correlation was carried out to study the correlation between hs-CRP levels and clinical parameters. Multivariate regression method was used to analyze the factors independently contributing to hs-CRP levels.
  
  
  RESULTS
  Hs-CRP levels were lower in patients with a larger number of risk factors reaching a desired value. In particular, triglyceride and body mass index (BMI) were independent risk factors determining hs-CRP levels in a multivariate regression analysis. Furthermore, we compared the influence of various factors on hs-CRP levels in both obese (BMI ≥25 kg/m(2)) and non-obese patients with type 2 diabetes (BMI <25 kg/m(2)). In obese groups, BMI and urinary albumin were independent risk factors determining hs-CRP levels, whereas triglyceride and statin were independent risk factors in non-obese patients.
  
  
  CONCLUSIONS
  There is some difference in the factors responsible for hs-CRP levels in obese and non-obese patients with type 2 diabetes.
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Shimoda
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshioka
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Seizo
authors.initials: S
authors.lastname: Okauchi
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Hirukawa
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanda-Kimura
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kohara
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamei
authors.affiliation: Division of General Internal Medicine 1 Kawasaki Medical School Kurashiki Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kawasaki
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki Japan.
authors.forename: Tomoatsu
authors.initials: T
authors.lastname: Mune
authors.affiliation: Division of General Internal Medicine 1 Kawasaki Medical School Kurashiki Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Kaku
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000150:complications; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002097:C-Reactive Protein
keywords: Body mass index; High‐sensitivity C‐reactive protein; Type 2 diabetes