title: Altered cerebellar-cerebral functional connectivity in benign adult familial myoclonic epilepsy.
abstract: The pathogenesis of benign adult familial myoclonic epilepsy (BAFME) remains unknown, although cerebellar pathologic changes and brain hyperexcitability have been reported. We used resting-state functional magnetic resonance imaging (fMRI) to examine the functional connectivity between the cerebellum and cerebrum in a Chinese family with BAFME for the first time.
  
  
  
  Eleven adults with BAFME and 15 matched healthy controls underwent resting-state blood oxygen level-dependent (BOLD) fMRI scanning. The cerebellar seeds, including the bilateral crus I, lobule VIII, lobule VIIb, and lobule IV&V, were defined a priori. Next, regional time courses were obtained for each individual by averaging the BOLD time series over all voxels in each seed region. Then, seed-based functional connectivity z-maps were produced by computing Pearson's correlation coefficients (converted to z-scores by Fisher transformation) between each seed signal and the time series from all other voxels within the entire brain. Finally, a second-level random-effect two-sample t-test was performed on the individual z-maps in a voxel-wise manner.
  
  
  
  Reduced functional connectivity of the right cerebellar crus I with the left middle frontal gyrus and right cerebellar lobule IX was observed in the default network of BAFME. Enhanced functional connectivity of the left cerebellar lobule VIII with the bilateral middle temporal gyri, right putamen, and left cerebellar crus I was found in the dorsal attention network of BAFME. Enhanced functional connectivity between the left cerebellar lobule VIIb and right frontal pole was found in the control network of BAFME.
  
  
  
  Altered cerebellar-cerebral functional connectivity may contribute to the understanding of the nosogenesis of BAFME and explain the cognitive dysfunction in this Chinese family with BAFME.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Long
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, China.
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Zeng
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.|Department of Emergency, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Song
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fang
authors.affiliation: Department of Neurology, Fuyang People's Hospital, Fuyang, Anhui, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Neurology, Fuyang People's Hospital, Fuyang, Anhui, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
authors.affiliation: Department of Neurology, Fuyang People's Hospital, Fuyang, Anhui, China.
authors.forename: Yun-Ci
authors.initials: YC
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Fuyang People's Hospital, Fuyang, Anhui, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Pinting
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Si
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xie
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, China.
authors.forename: Dewen
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004569:Electroencephalography; D004576:Electromyography; D004831:Epilepsies, Myoclonic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Benign adult familial myoclonic epilepsy; Default network; Functional connectivity; Functional magnetic resonance imaging; Resting state