title: Self-assembled nanofiber hydrogels for mechanoresponsive therapeutic anti-TNFα antibody delivery.
abstract: Low molecular weight hydrogels, prepared from glycosyl-nucleoside-lipid amphiphiles, exhibit shear-thinning behaviour and reversible thermally- and mechanically-triggered sol-gel transitions. Using mechanical shear stimulation, the release of entrapped anti-TNFα increases and the released anti-TNFα demonstrates efficacy in in vitro neutralization bioassays. Delivery of anti-TNFα is of general interest and broad medicinal utility for treating autoimmune diseases such as rheumatoid arthritis.
authors.affiliation: Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, USA. mgrin@bu.edu.
authors.forename: J A
authors.initials: JA
authors.lastname: Kaplan
authors.forename: P
authors.initials: P
authors.lastname: Barthélémy
authors.forename: M W
authors.initials: MW
authors.lastname: Grinstaff
mesh_terms: D000818:Animals; D002460:Cell Line; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D007074:Immunoglobulin G / Q000008:administration & dosage*; D055595:Mechanical Phenomena; D051379:Mice; D057139:Nanofibers / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry; D009829:Oleic Acids / Q000737:chemistry; D044367:Phase Transition; D011817:Rabbits; D014230:Triazoles / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D003911:Dextrans; D004337:Drug Carriers; D006027:Glycosides; D020100:Hydrogels; D007074:Immunoglobulin G; D009705:Nucleosides; D009829:Oleic Acids; D014230:Triazoles; D014409:Tumor Necrosis Factor-alpha; C015219:fluorescein isothiocyanate dextran; C029407:oleylamide; D016650:Fluorescein-5-isothiocyanate