title: Clinical Features and Prognostic Factors of Patients With Nerve Sheath Tumors in the Cervical Spine.
abstract: METHODS
  A retrospective study was performed.
  
  
  OBJECTIVE
  The aim of the study was to illustrate the long-term follow-up results and discuss the possible factors that may affect outcomes of patients with cervical spinal nerve sheath tumors (CSNSTs).
  
  
  BACKGROUND
  Nerve sheath tumors are the most common neoplasms in the spine, but minimal information was published in the literature, especially when regarding to prognostic factors due to the benign nature. The objective of our study was to present long-term follow-up results and discuss the possible factors that may affect outcomes of patients with CSNSTs.
  
  
  METHODS
  A retrospective analysis of patients with CSNSTs was performed by survival analysis. The local relapse-free survival (LRFS) and overall survival (OS) rates were estimated using the Kaplan-Meier method to identify potential prognostic factors. Factors with P values ≤0.1 were subjected to multivariate analysis by Cox regression analysis. P values ≤0.05 were considered statistically significant.
  
  
  RESULTS
  A total of 169 patients with CSNSTs were included in the study. All patients received surgical treatment. The mean follow-up period was 72.1 months (median 62.0, range 1-158). Local recurrence was detected in 14 patients after surgery in our center, whereas death occurred in 9 patients with a mean follow-up of 27.2 months (median 24, range 1-84). The statistical analyses suggested that resection mode and pathology type were independent prognostic factors for LRFS and OS. In addition, postoperative recurrence was an adverse independent factor to OS.
  
  
  CONCLUSIONS
  Total resection could significantly improve the LRFS and OS for patients with CSNSTs, whereas malignant CSNST was associated with worse prognosis. Moreover, postoperative recurrence was an adverse independent factor to OS.
  
  
  METHODS
  4.
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Huabin
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Meng
authors.affiliation: Department of Oncology, The Ninth People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Pingting
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Weiluo
authors.initials: W
authors.lastname: Cai
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Tianrui
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Jianru
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002574:Cervical Vertebrae / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007796:Laminectomy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018317:Nerve Sheath Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D015996:Survival Rate; D055815:Young Adult