title: State-of-the-Art Metabolic Toxicity Screening and Pathway Evaluation.
abstract: Routine in vitro bioassays and animal toxicity studies of drug and environmental chemical candidates fail to reveal toxicity in ∼30% of cases. This Feature article addresses research on new approaches to in vitro toxicity testing as well as our own efforts to produce high-throughput genotoxicity arrays and LC-MS/MS approaches to reveal possible chemical pathways of toxicity.
authors.affiliation: Department of Chemistry, East Carolina University Greenville, North Carolina 27858, United States.
authors.forename: Eli G
authors.initials: EG
authors.lastname: Hvastkovs
authors.affiliation: Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.|Department of Surgery and Neag Cancer Center, University of Connecticut Health Center , Farmington, Connecticut 06032, United States.|Institute of Material Science, University of Connecticut , Storrs, Connecticut 06269, United States.|School of Chemistry, National University of Ireland at Galway , Galway, Ireland.
authors.forename: James F
authors.initials: JF
authors.lastname: Rusling
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D064420:Drug-Related Side Effects and Adverse Reactions; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D004364:Pharmaceutical Preparations; D053719:Tandem Mass Spectrometry; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations