title: Lamotrigine-induced Hypersensitivity Syndrome with Histologic Features of CD30+ Lymphoma.
abstract: Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotrigine-induced DRESS with histologic features of a cutaneous CD30+ lymphoma. The patient responded well to a tapering course of oral steroids. This case highlights the atypical presentation of a lamotrigine-induced DRESS/DIHS in the presence of a cutaneous and a lymph node CD30 + lymphocytic infiltrate mimicking systemic lymphoma. Pathologists and clinicians must be aware of this "lymphomatous" presentation of drug reactions.
authors.affiliation: Department of Dermatology, Hotel-Dieu de France University Hospital, Beirut, Lebanon.
authors.forename: Farid
authors.initials: F
authors.lastname: Stephan
authors.affiliation: Department of Dermatology, Hotel-Dieu de France University Hospital, Beirut, Lebanon.
authors.forename: Roger
authors.initials: R
authors.lastname: Haber
authors.affiliation: Department of Dermatology, Hotel-Dieu de France University Hospital, Beirut, Lebanon.
authors.forename: Elio
authors.initials: E
authors.lastname: Kechichian
authors.affiliation: Department of Oncology, Bellevue Medical Center, Beirut, Lebanon.
authors.forename: Francois
authors.initials: F
authors.lastname: Kamar
keywords: Drug rash with eosinophilia and systemic symptoms; hypersensitivity syndrome; lamotrigine; lymphoma; pseudolymphoma