title: Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats.
abstract: Background To investigate the protective effects of Quercetin administration associated with chronic moderate exercise (training) on oxidative stress in the liver in streptozotocin-induced diabetic rats. Methods Diabetic rats that performed exercise training were subjected to a swimming training program (1 hour/day, 5 days/week, 4 weeks). The diabetic rats received natural antioxidant, Quercetin (20 mg/kg body weight/day) for 4 weeks. At the end of the study, all animals were sacrificed and liver samples were collected for estimation: some oxidative stress markers (malondialdehyde, MDA and protein carbonyls groups, PC), the activity of antioxidant enzymes (superoxide dismutase, SOD and catalase, CAT), reduced glutathione (GSH) level and reduced (GSH) and oxidized (GSSG) glutathione ratio. Results Diabetic rats submitted to exercise training showed significantly increased the oxidative stress markers (MDA and PC) and a reduction of antioxidant enzyme (SOD and CAT) activity, GSH level and GSH/ GSSG ratio in hepatic tissues. A decrease in the levels of oxidative stress markers associated with elevated activity of antioxidant enzymes, the GSH level and GSH/GSSG ratio in the hepatic tissue were observed in Quercetin-treated diabetic trained rats. Conclusions These findings suggest that Quercetin administration in association with chronic moderate exercise exerts a protective effect in diabetes by attenuating hyperglycemia-mediated oxidative stress in hepatic tissue.
authors.affiliation: Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania.
authors.forename: I C
authors.initials: IC
authors.lastname: Chiş
authors.affiliation: Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania.
authors.forename: A
authors.initials: A
authors.lastname: Mureşan
authors.affiliation: Department of Veterinary Toxicology, University of Agricultural Sciences and Veterinary Medicine , Cluj-Napoca , Romania.
authors.forename: A
authors.initials: A
authors.lastname: Oros
authors.affiliation: Department of Veterinary Toxicology, University of Agricultural Sciences and Veterinary Medicine , Cluj-Napoca , Romania.
authors.forename: A L
authors.initials: AL
authors.lastname: Nagy
authors.affiliation: Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania.
authors.forename: S
authors.initials: S
authors.lastname: Clichici
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D019610:Cytoprotection / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010805:Physical Conditioning, Animal / Q000379:methods / Q000502:physiology*; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008315:Malondialdehyde; D013311:Streptozocin; D011794:Quercetin
keywords: Quercetin; chronic moderate exercise; diabetes mellitus; liver; oxidative stress