title: 2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp(3))-H Functionalization of Trifluoroacetimidoyl Chlorides.
abstract: Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp(3))-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from anilines. The cyclization operates with catalyst loadings as low as 1 mol % and accommodates a variety of substituents.
authors.affiliation: Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland.
authors.forename: Julia
authors.initials: J
authors.lastname: Pedroni
authors.affiliation: Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland.
authors.forename: Nicolai
authors.initials: N
authors.lastname: Cramer