title: Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.
abstract: Curcumin is potentially therapeutic for malignant diseases. The mechanisms of this effect might involve a combination of antioxidant, immunomodulatory, proapoptotic, and antiangiogenic activities. However, the exact mechanisms are not fully understood. In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally. Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101. Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2. There was a reciprocal regulation between EZH2 and NOTCH1 in lung cancer cells. These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Wu
authors.affiliation: Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
authors.forename: Ke-Qun
authors.initials: KQ
authors.lastname: Chai
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Xiu-Ming
authors.initials: XM
authors.lastname: Zhu
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xue
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Ai-Hong
authors.initials: AH
authors.lastname: Zheng
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Zhou
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Chen
authors.affiliation: Department of Biochemistry, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Xiao
authors.affiliation: Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
authors.forename: Xu-Hua
authors.initials: XH
authors.lastname: Ying
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Fu-Wei
authors.initials: FW
authors.lastname: Wang
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Rui
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China.
authors.forename: Yi-Ji
authors.initials: YJ
authors.lastname: Liao
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Lu
authors.affiliation: Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D000071221:Enhancer of Zeste Homolog 2 Protein / Q000096:biosynthesis*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D051881:Receptor, Notch1 / Q000096:biosynthesis*
chemical_list: D000970:Antineoplastic Agents; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D003474:Curcumin
keywords: NOTCH1; curcumin; enhancer of zeste homolog 2; lung cancer; microRNA