title: Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells.
abstract: The interaction of tumor cells with the microenvironment is like a relationship between the "seeds" and "soil," which is a hotspot in recent cancer research. Targeting at tumor microenvironment as well as tumor cells has become a new strategy for cancer treatment. Conventional cancer treatments mostly focused on single targets or single mechanism (the seeds or part of the soil); few researches intervened in the whole tumor microenvironment and achieved ideal therapeutic effect as expected. Traditional Chinese medicine displays a broad range of biological effects, and increasing evidence has shown that it may relate with synergistic effect on regulating tumor microenvironment and cancer cells. Based on literature review and our previous studies, we summarize the synergistic effect and the molecular mechanisms of traditional Chinese medicine on regulating tumor microenvironment and cancer cells.
authors.affiliation: Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China; Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang District, Beijing 100029, China.
authors.forename: Jingnan
authors.identifier: 0000-0002-8986-4424
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China; China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie Dongzhimennei, Dongcheng District, Beijing 100700, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China; Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang District, Beijing 100029, China.
authors.forename: Qiujun
authors.identifier: 0000-0001-6600-9540
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D006801:Humans; D008516:Medicine, Chinese Traditional; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D059016:Tumor Microenvironment / Q000187:drug effects* / Q000235:genetics
chemical_list: D004365:Drugs, Chinese Herbal