title: TandemPET- A High Resolution, Small Animal, Virtual Pinhole-Based PET Scanner: Initial Design Study.
abstract: Mice are the perhaps the most common species of rodents used in biomedical research, but many of the current generation of small animal PET scanners are non-optimal for imaging these small rodents due to their relatively low resolution. Consequently, a number of researchers have investigated the development of high-resolution scanners to address this need. In this investigation, the design of a novel, high-resolution system based on the dual-detector, virtual-pinhole PET concept was explored via Monte Carlo simulations. Specifically, this system, called TandemPET, consists of a 5 cm × 5 cm high-resolution detector made-up of a 90 × 90 array of 0.5 mm × 0.5 mm × 10 mm (pitch= 0.55 mm) LYSO detector elements in coincidence with a lower resolution detector consisting of a 68 × 68 array of 1.5 mm × 1.5 mm × 10 mm LYSO detector elements (total size= 10.5 cm × 10.5 cm). Analyses indicated that TandemPET's optimal geometry is to position the high-resolution detector 3 cm from the center-of-rotation, with the lower resolution detector positioned 9 cm from center. Measurements using modified NEMA NU4-2008-based protocols revealed that the spatial resolution of the system is ~0.5 mm FWHM, after correction of positron range effects. Peak sensitivity is 2.1%, which is comparable to current small animal PET scanners. Images from a digital mouse brain phantom demonstrated the potential of the system for identifying important neurological structures.
authors.affiliation: Center for Advanced Imaging, Department of Radiology at West Virginia University.
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Raylman
authors.affiliation: Center for Advanced Imaging, Department of Radiology at West Virginia University.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Stolin
authors.affiliation: Center for Advanced Imaging, Department of Radiology at West Virginia University.
authors.forename: Peter F
authors.initials: PF
authors.lastname: Martone
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine at the University of Maryland School of Medicine.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Smith
keywords: Monte Carlo Simulation; PET Instrumentation; Small Animal Imaging