title: Mechanisms and consequences of entosis.
abstract: Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
authors.affiliation: Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.|Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
authors.forename: Shefali
authors.initials: S
authors.lastname: Krishna
authors.affiliation: Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. overhom1@mskcc.org.|Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. overhom1@mskcc.org.
authors.forename: Michael
authors.initials: M
authors.lastname: Overholtzer
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology; D063646:Carcinogenesis / Q000473:pathology*; D057691:Entosis / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D010587:Phagocytosis / Q000502:physiology*
keywords: Aneuploidy; Autophagy; Cannibalism; Cell competition; Cell-in-cell; Engulfment; Entosis; Entotic cell death; LAP; Phagocytosis