title: Can thıamıne pyrophosphate prevent desflurane ınduced hepatotoxıcıty ın rats?
abstract: OBJECTIVE
  To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity.
  
  
  METHODS
  Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG) , TPP and desflurane group (TDG). 20 mg/kg TPP was injected to intraperitoneally TDG. After one hour of TPP administration, desflurane was applied for two hours. After 24 hours, liver tissues of the animals killed with decapitation were removed. The oxidant/antioxidant levels and ALT, AST and LDH activities were measured. The histopathological examinations were performed in the liver tissues for all rats.
  
  
  RESULTS
  Notwithstanding the levels of oxidants and liver enzymes were significantly increased (p<0.0001), antioxidant levels were significantly decreased in DCG (p<0.0001). On contrary to the antioxidant parameters were increased (p<0.05) the oxidant parameters and liver enzymes were decreased in TDG (p<0.0001). Whereas multiple prominent, congestion, hemorrhage and dilatation were observed in sinusoids and lymphocyte-rich inflammation results in the centrilobular and portal areas of liver tissue in DCG, these findings were observed less frequently in TDG. CONCLUSİON : Thiamine pyrophosphate prevented liver oxidative damage induced with desflurane and may be useful in prophylaxis of desflurane induced hepatotoxicity.
authors.affiliation: Department of Internal Medicine, Istinye State Hospitale, Istanbul, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Arslan
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan University, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Kuyrukluyildiz
authors.affiliation: Department of Anesthesiology and Reanimation, Mengucekgazi Training Hospital, Erzincan, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Binici
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Erzincan University, Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Cetin
authors.affiliation: Department of Pathology, Faculty of Medicine, Erzincan University, Turkey.
authors.forename: Mecdi Gurhan
authors.initials: MG
authors.lastname: Balci
authors.affiliation: Department of Biology, Science and Art Faculty, Erzincan University, Erzincan, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kuzucu
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Yilmaz
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Erzincan University, Turkey.
authors.forename: Durdu
authors.initials: D
authors.lastname: Altuner
authors.affiliation: Department of Clinical Biochemistry, School of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Taha Abdulkadir
authors.initials: TA
authors.lastname: Coban
mesh_terms: D000410:Alanine Transaminase / Q000187:drug effects / Q000378:metabolism; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D000077335:Desflurane; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives*; D007770:L-Lactate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D023421:Models, Animal; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D009195:Peroxidase / Q000187:drug effects / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D017208:Rats, Wistar; D013835:Thiamine Pyrophosphate / Q000627:therapeutic use*
chemical_list: D018685:Anesthetics, Inhalation; D020011:Protective Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; D000077335:Desflurane; D007530:Isoflurane; D007770:L-Lactate Dehydrogenase; D009195:Peroxidase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D013835:Thiamine Pyrophosphate