title: [Alterations and clinical implications of interleukin 23 and pepsinogen 1 in the sera and tissues of patients with gastric diseases].
abstract: OBJECTIVE
  To explore the alteration and clinical significance of interleukin 23 (IL-23) and pepsinogen 1 (PG1) in the sera and tissues of patients with gastric diseases.
  
  
  METHODS
  The study collected the tissues of chronic superficial gastritis, chronic atrophic gastritis with intestinal metaplasia, gastric cancer as wells as the peripheral blood samples from the patients suffering from the three kinds of gastric diseases. Immunohistochemical staining was performed to detect IL-23 expression in the gastric involved tissues from these patients. The concentrations of serum PG1 were determined by time-resolved fluoroimmunoassay and the levels of serum IL-23 were detected by ELISA. The relationships between the serum IL-23 and PG1 in chronic atrophic gastritis with intestinal metaplasia tissues or gastric cancer tissues were analyzed by Pearson correlation analysis.
  
  
  RESULTS
  Compared with the chronic superficial gastritis tissues, the expression of IL-23 significantly increased in chronic atrophic gastritis with intestinal metaplasia tissues and gastric cancer tissues, so did the serum IL-23. Nevertheless, the expression level of serum PG1 significantly decreased in chronic atrophic gastritis with intestinal metaplasia group and gastric cancer group. There was a negative correlation between IL-23 and PG1 in the chronic atrophic gastritis with intestinal metaplasia group or in gastric cancer group.
  
  
  CONCLUSIONS
  Enhanced expression of IL-23 occurred in chronic atrophic gastritis with intestinal metaplasia tissue and gastric cancer tissue, and serum IL-23 had a negative correlation with PG1.
authors.affiliation: Department of Gastroenterology, Department of Nuclear Medicine, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Chaoming
authors.initials: C
authors.lastname: Mao
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China. *Corresponding author, E-mail: jszjwy@hotmail.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005756:Gastritis / Q000097:blood* / Q000473:pathology; D005757:Gastritis, Atrophic / Q000097:blood / Q000473:pathology; D006801:Humans; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D053759:Interleukin-23; D020116:Pepsinogen A