title: The real role of pseudokinase: linking diabetes to cancers.
abstract: A recent paper in Nature Communications shows that pseudokinase TRIB3 has a critical role in the development of diabetes-related cancers via interacting with SQSTM1, a selective autophagy receptor. Interrupting the TRIB3-SQSTM1 interaction using an α-helix peptide shows a significant antitumor effect both in normal and diabetic mice. This work provides a potential strategy against cancers in patients with diabetes.
authors.affiliation: Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing, 100050, China.|Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.affiliation: Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing, 100050, China.
authors.forename: Zhuowei
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000818:Animals; D001343:Autophagy; D018797:Cell Cycle Proteins; D003921:Diabetes Mellitus, Experimental; D006801:Humans; D007328:Insulin; D051379:Mice; D009369:Neoplasms
chemical_list: D018797:Cell Cycle Proteins; D007328:Insulin; C474830:TRB3 protein, mouse
keywords: Autophagy; SQSTM1; TRIB3; UPS; protein-protein interaction; α-helix peptide