title: Prostatic Bleeding after Prostatic Biopsy Effects Oncological Outcomes with Laparoscopic Radical Prostatectomy.
abstract: BACKGROUND
  We vigorously reviewed patients' operation record who had adhesion of the Denonvilliers' fascia and found out most of these patients had prostatic bleeding after prostatic gland biopsies. We examined the magnitude of prostatic bleeding and frequency after biopsies and the relationship with oncological outcomes.
  
  
  METHODS
  A total of 285 patients were selected for the final analyses. Inclusion criteria were as follows: receiving MRI three weeks after biopsiesand laparoscopic radical prostatectomy within 300 days after biopsy. We divided the patients into two groups with (group A) or without (group B) prostatic bleeding. We examined the magnitude of prostatic bleeding after biopsies and the relationship with operation time (OT), positive surgical margin (PSM), biochemical recurrence (BCR) and other factors. Furthermore, we created a logistic-regression model to derive a propensity score for prostatic bleeding after biopsies, which included all patient and hospital characteristics as well as selected interaction terms, and we examined the relationship with PSM and BCR.
  
  
  RESULTS
  In all patients, the OT in the group B was shorter than the group A (p < 0.001). Prostatic bleeding was associated with PSM (p=0.000) and BCR (p=0.036). In this propensity-matched cohort, 11 of 116 patients in the group B had PSM as compared with 36 of 116 patients from group A (match-adjusted odds ratio, 4.30; 95%CI confidence interval, 2.06 to 8.96; P=0.000). In addition, eight of 116 patients in group B encountered BCR, as compared with 18 of 116 patients in group A (match-adjusted odds ratio, 2.48; 95%CI, 1.03 to 5.96; P=0.042). Kaplan-Meier analysis in the propensity matching cohort showed a significant biochemical recurrence-free survival advantage for being free of prostate bleeding after biopsies.
  
  
  CONCLUSIONS
  Our findings in the present cohort should help equip surgeons to pay attention to careful excision especially for those who experienced deferred prostatic bleeding.
authors.affiliation: Department of Urology, Osaka Medical College, Osaka, Japan E-mail : uro055@poh.osaka-med.ac.jp.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Takai
authors.forename: Teruo
authors.initials: T
authors.lastname: Inamoto
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Komura
authors.forename: Takuya
authors.initials: T
authors.lastname: Tsujino
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Taizo
authors.initials: T
authors.lastname: Uchimoto
authors.forename: Kenkichi
authors.initials: K
authors.lastname: Saito
authors.forename: Naoki
authors.initials: N
authors.lastname: Tanda
authors.forename: Koichiro
authors.initials: K
authors.lastname: Minami
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Uehara
authors.forename: Naokazu
authors.initials: N
authors.lastname: Ibuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takahara
authors.forename: Hayahito
authors.initials: H
authors.lastname: Nomi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kiyama
authors.forename: Hayahito
authors.initials: H
authors.lastname: Azuma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000009:adverse effects*; D016063:Blood Loss, Surgical; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D019106:Postoperative Hemorrhage / Q000209:etiology*; D011379:Prognosis; D011468:Prostatectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate