title: Immune-associated parameters and antioxidative responses to cadmium in the freshwater crab Sinopotamon henanense.
abstract: Cadmium (Cd) is a toxic heavy metal pollutant and is known to exert adverse effects in organisms. In this study, we examined immune-related and antioxidative parameters in crabs exposed to sublethal levels of Cd. The results showed that Cd exposure elicited a significant accumulation in hemolymph, a decrease in total hemocyte counts, and the production of reactive oxygen species (ROS). Cd treatment also upregulated activities of antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase in the hemocytes of crabs. Treatment with Cd further decreased the stability of lysosomal membranes in hemocytes and induced substantial changes of immune-related parameters including acid phosphatase and alkaline phosphatase. However, the activity of lysozyme varied weakly throughout the Cd treatment period. Our results suggest that Cd exposure caused immunomodulation, a potentially harmful immunity function and damage in the antioxidant system of Sinopotamon henanense.
authors.affiliation: College of Life Science, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Yanying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, No. 70, Lienhai Road, Kaohsiung 80424, Taiwan ROC.
authors.forename: Hans-Uwe
authors.initials: HU
authors.lastname: Dahms
authors.affiliation: College of Life Science, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Dong
authors.affiliation: College of Life Science, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Jing
authors.affiliation: College of Life Science, Shanxi University, Taiyuan, Shanxi 030006, China. Electronic address: lanwang@sxu.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003386:Brachyura / Q000187:drug effects* / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D005618:Fresh Water; D005979:Glutathione Peroxidase / Q000378:metabolism; D006434:Hemocytes / Q000187:drug effects / Q000378:metabolism; D007107:Immune System / Q000187:drug effects / Q000378:metabolism; D056747:Immunomodulation / Q000187:drug effects; D009113:Muramidase / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D002104:Cadmium; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D009113:Muramidase
keywords: Antioxidative enzymes; Cadmium; Immune response; Sinopotamon henanense