title: [Caspase-1 regulates autoinflammation in rheumatic diseases].
abstract: Caspase-1 is an integral regulator of the innate immune system. Its core functions are the processing and secretion of the proinflammatory cytokines interleukin 1β (IL-1 beta) and IL-18 and the initiation of proinflammatory cell death, which is referred to as pyroptosis. Activation of caspase-1 plays a pivotal role during immune defense mechanisms against infections by the innate immune system. Dysregulated activation of caspase-1 has been recognized to be involved in the pathophysiology of a constantly increasing number of inflammatory diseases. This article gives an overview of the regulation and function of caspase-1 and its involvement in monogenic, polygenic and/or polyetiological rheumatic diseases.
authors.affiliation: Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland. stefan.winkler@uniklinikum-dresden.de.
authors.forename: S
authors.initials: S
authors.lastname: Winkler
authors.affiliation: Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
authors.forename: C M
authors.initials: CM
authors.lastname: Hedrich
authors.affiliation: Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Rösen-Wolff
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D020170:Caspase 1 / Q000276:immunology*; D004789:Enzyme Activation / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007155:Immunologic Factors / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D020382:Interleukin-18 / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology; D018448:Models, Immunological; D012216:Rheumatic Diseases / Q000276:immunology*
chemical_list: D007155:Immunologic Factors; D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D020170:Caspase 1
keywords: Cytokines; Immune system; Inflammasomes; Pyroptosis; Targeted therapy