title: [Role of PDLIM4 and c-Src in Breast Cancer Progression].
abstract: High heterogeneity is characteristic of oncology diseases, often complicating the choice of optimal anticancer treatment. One cancer type may combine tumors differing in histogenesis, genetic lesions, and mechanism of cell transformation. Differences in the mechanism of cell malignant transformation result in specifics of cancer cell metabolism and sensitivity to various agents, including anticancer treatments. Hence, the molecular subtype of a tumor is essential to know for choosing the optimal therapeutic strategy. The review considers the role actin-associated proteins and tyrosine kinases, in particular, PDLIM4 and Src kinase, play in the formation of pathological signaling pathways.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.|Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Kravchenko
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Frolova
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.|Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
authors.forename: J E
authors.initials: JE
authors.lastname: Kravchenko
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.|Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.|stepan@chumakov.com.
authors.forename: S P
authors.initials: SP
authors.lastname: Chumakov
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D060588:LIM Domain Proteins / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D019061:src-Family Kinases / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D060588:LIM Domain Proteins; C486247:PDLIM4 protein, human; D019061:src-Family Kinases
keywords: HER2; PDLIM4; RIL; biomarker; breast cancer; c-Src; tumor subtype