title: Anterior Cervical Corpectomy Non-Fusion Model Produced by a Novel Implant.
abstract: BACKGROUND
  Anterior cervical corpectomy and fusion are frequently used in the treatment of cervical spinal disease. However, the range of motion (ROM) of the operative level is unavoidably lost due to fusion. This study aims to establish an anterior cervical corpectomy goat non-fusion model and to evaluate the ROM of adjacent and operative levels.
  
  
  METHODS
  Six adult-male goats (in vivo group) and twelve adult-male goat cervical spine specimens (randomly divided equally into intact group or in vitro group) were included. The non-fusion model was established by implanting a novel implant at C4 level. Imagiological examinations for the in vivo group were performed to inspect the position of the implant and spinal cord status. Specimens were harvested six months after the operation. Biomechanical testing was conducted to obtain the ROM in flexion-extension, lateral bending, and axial rotation at upper adjacent level (C(2-3)), operative levels (C(3-4) and C(4-5)) and at C(2-5). Specimens in the intact group were first tested as intact and then tested as fixed and became the fixation group.
  
  
  RESULTS
  Imagiological examinations revealed that the position of the implant and the spinal cord status were good. The specimens in the in vivo and in vitro groups had significantly decreased C(2-3) ROM, increased C(3-4) and C(4-5) ROM and similar C(2-5) ROM compared with the fixation group.
  
  
  CONCLUSIONS
  This study presents a novel method for potential non-fusion treatment strategies for cervical spinal disease. However, improvement of this model and additional studies are needed.
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
authors.forename: Meng
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Plastic Surgery, Second Afﬁliated Hospital of Xi'an Jiaotong Universit, Xi'an, Shaanxi, China (mainland).
authors.forename: Baobao
authors.initials: B
authors.lastname: Liang
authors.affiliation: Department of Emergency, Second Afﬁliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
authors.forename: Xu
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
authors.forename: Xijing
authors.initials: X
authors.lastname: He
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006041:Goats; D020007:Implants, Experimental; D008297:Male; D023421:Models, Animal; D016059:Range of Motion, Articular; D013123:Spinal Fusion / Q000379:methods*