title: Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities.
abstract: The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Jafari
authors.affiliation: Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
authors.forename: Marzieh Rahmani
authors.initials: MR
authors.lastname: Khajouei
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Hassanzadeh
authors.affiliation: Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan.
authors.forename: Gholam Hossein
authors.initials: GH
authors.lastname: Hakimelahi
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors.forename: Ghadam Ali
authors.initials: GA
authors.lastname: Khodarahmi
keywords: Antimicrobial; Cytotoxic; Quinazoline; Quinazolinones