title: Epidemiology of Oral Lichen Planus in a Cohort of South Indian Population: A Retrospective Study.
abstract: BACKGROUND
  Oral lichen planus (OLP) is an immune-mediated potentially malignant disorder of the oral cavity. Dysplastic OLP has an altered cytogenic profile and can progress into oral squamous cell carcinoma. The epidemiology of OLP is well-described in several relatively large series from various geographic locations, whereas such series from southern India is rare. The aim of the present study was to determine the epidemiology of OLP in a cohort of South Indian population.
  
  
  METHODS
  All the case data records of 29,606 patients who visited Mar Baselios Dental College and Hospital, Kerala, India from 2014 to 2015 were retrospectively reviewed. For data review, 122 patients of OLP were selected Estimated were type, number, and location of lesions, clinical manifestation, age of the patient, gender, onset and duration of lesion, stressful life style, habits, skin involvement and associated systemic illness, and presence/absence of dysplasia.
  
  
  RESULTS
  When the distribution of OLP among the gender was considered, we found more prevalence in females than males. Fifty-seven percent of patients were associated with stressful lifestyle. Reticular lichen planus was the most common clinical subtype found. Bilateral buccal mucosal was the common site, when the distribution of sites of OLP were compared (P < 0.05). Hypersensitivity reaction was frequently associated with systemic illness with OLP (P < 0.05). Anaplasia was found among 5% of lichen planus lesions.
  
  
  CONCLUSIONS
  OLP patients had high incidence of hypersensitivity reactions and 5% of OLP lesions showed anaplasia. Long term follow-up is necessary to monitor the recurrence, prognosis, and malignant transformation of OLP.
authors.affiliation: Department of Oral Pathology and Microbiology, Mar Baselios Dental College and Hospital, Kothamangalam, India.
authors.forename: Soma Susan
authors.initials: SS
authors.lastname: Varghese
authors.affiliation: Department of Oral Medicine and Radiology, Mar Baselios Dental College and Hospital, Kothamangalam, India.
authors.forename: Giju Baby
authors.initials: GB
authors.lastname: George
authors.affiliation: Department of Oral Pathology and Microbiology, Mar Baselios Dental College and Hospital, Kothamangalam, India.
authors.forename: Sreenivasan Bargavan
authors.initials: SB
authors.lastname: Sarojini
authors.affiliation: Department of Oral and Maxillofacial Surgery, Mar Baselios Dental College and Hospital, Kothamangalam, India.
authors.forename: Sankar
authors.initials: S
authors.lastname: Vinod
authors.affiliation: Department of Oral Medicine and Radiology, Government Dental College, Kottayam, India.
authors.forename: Philips
authors.initials: P
authors.lastname: Mathew
authors.affiliation: Department of Oral Pathology and Microbiologyy, Mar Baselios Dental College, Kothamangalam, India.
authors.forename: Deepu George
authors.initials: DG
authors.lastname: Mathew
authors.affiliation: Department of Oral and Maxillofacial Surgery, Mar Baselios Dental College, Kothamangalam, India.
authors.forename: Joseph
authors.initials: J
authors.lastname: Sebastian
authors.affiliation: Department of Oral and Maxillofacial Surgery, Mar Baselios Dental College, Kothamangalam, India.
authors.forename: Arun
authors.initials: A
authors.lastname: George
keywords: Immunologic diseases; Lichen planus; Precancer