title: Graphene-Templated Synthesis of Magnetic Metal Organic Framework Nanocomposites for Selective Enrichment of Biomolecules.
abstract: Successful control of homogeneous and complete coating of graphene or graphene-based composites with well-defined metal organic framework (MOF) layers is a great challenge. Herein, novel magnetic graphene MOF composites were constructed via a simple strategy for self-assembly of well-distributed, dense, and highly porous MOFs on both sides of graphene nanosheets. Graphene functionalized with magnetic nanoparticles and carboxylic groups on both sides was explored as the backbone and template to direct the controllable self-assembly of MOFs. The prepared composite materials have a relatively high specific surface area (345.4 m(2) g(-1)), and their average pore size is measured to be 3.2 nm. Their relatively high saturation magnetization (23.8 emu g(-1)) indicates their strong magnetism at room temperature. Moreover, the multifunctional composite was demonstrated to be a highly effective affinity material in selective extraction and separation of low-concentration biomolecules from biological samples, in virtue of the size-selection property of the unique porous structure and the excellent affinity of the composite materials. Besides providing a solution for the construction of well-defined functional graphene-based MOFs, this work could also contribute to selective extraction of biomolecules, in virtue of the universal affinity between immobilized metal ions and biomolecules.
authors.affiliation: Department of Biomedical Engineering, ‡Material Research Institute, and §Department of Biology, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Gong
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Biomedical Engineering, ‡Material Research Institute, and §Department of Biology, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, ‡Material Research Institute, and §Department of Biology, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Sachira
authors.initials: S
authors.lastname: Denagamage
authors.affiliation: Department of Biomedical Engineering, ‡Material Research Institute, and §Department of Biology, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Si-Yang
authors.initials: SY
authors.lastname: Zheng
mesh_terms: D006108:Graphite; D008280:Magnetics; D008670:Metals; D053761:Nanocomposites; D016062:Porosity
chemical_list: D008670:Metals; D006108:Graphite
keywords: biomolecules; graphene; magnetic separation; metal organic frameworks; nanocomposites; selective extraction