title: The role of microRNA-26a in human cancer progression and clinical application.
abstract: MicroRNAs, a class of endogenous, small (18-25 nucleotides) noncoding RNAs, regulate gene expression by directly binding to the 3'-untranslated regions of target messenger RNAs. Evidence has shown that alteration of microRNAs is involved in cancer initial and progression. MicroRNA-26a is commonly dysregulated in diverse cancers and is involved in various biological processes, including proliferation, migration, invasion, angiogenesis, and metabolism by targeting multiple mRNAs. This review summarizes current research on the physiology and pathological functions of miR-26a and its applications for clinical therapy.
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, 305 Zhong Shan Road East, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, 305 Zhong Shan Road East, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, People's Republic of China.
authors.forename: Yuejuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, 305 Zhong Shan Road East, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, 305 Zhong Shan Road East, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, 305 Zhong Shan Road East, Nanjing, Jiangsu Province, People's Republic of China. wangrui1977218@163.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, 305 Zhong Shan Road East, Nanjing, Jiangsu Province, People's Republic of China. chenlongbang@yeah.net.
authors.forename: Longbang
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D009389:Neovascularization, Pathologic
chemical_list: D035683:MicroRNAs
keywords: Cancer progression; Clinical application; MicroRNA-26a; Pathological functions