title: Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer's Disease.
abstract: The relationship between the insulin-like growth factor-I (IGF-I) system and Alzheimer's disease (AD) is mostly based on transversal studies. It remains, however, to demonstrate whether IGF-I is associated with cognitive decline over time in AD.
  
  
  
  The objective of the study was to analyze the course of cognitive decline of AD subjects over a 24-month period in relation to serum IGF-I and insulin-like growth factor binding protein-3 (IGFBP-3) measured at baseline.
  
  
  
  Data are from the SIGAL follow-up study. IGF-I and IGFBP-3 were measured in AD subjects who performed a Mini-Mental State Examination (MMSE) every 6 months for 2 years. MMSE course was analyzed using a mixed model with random intercept and slope function.
  
  
  
  Among the 200 AD participants, 146 (mean age = 81.1 (standard deviation (SD) = 5.9) years, 62.6% of women) had at least one follow-up visit. Mean IGF-I at baseline was 147.8 (74.2) ng/mL. Hundred forty-six participants (62.6%) had at least one follow-up visit. Mean MMSE was 21.7 (4.7)/30 and dropped on average by 2.28 points per year. MMSE decline was steeper among participants with lower IGF-I. For each decrease of 1 SD of IGF-I, subjects lost an additional 0.63 points per year in MMSE, e.g., participants with IGF-I level of 74 ng/mL lost 2.91 MMSE points per year whereas participants with IGF-I of 222 ng/mL lost 1.65 MMSE points per year. There was no association between IGFBP-3 and cognitive decline.
  
  
  
  Lower baseline serum IGF-I was associated with faster cognitive decline in AD over a 2-year period.
authors.affiliation: AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Vidal
authors.affiliation: AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hanon
authors.affiliation: INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Funalot
authors.affiliation: INSERM, IFR65, Paris, France.
authors.forename: Nadège
authors.initials: N
authors.lastname: Brunel
authors.affiliation: INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Viollet
authors.affiliation: AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Rigaud
authors.affiliation: AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Seux
authors.affiliation: INSERM/UPMC, Paris VI, UMRS 938, Centre de Recherche St-Antoine, Paris, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: le-Bouc
authors.affiliation: INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Epelbaum
authors.affiliation: AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Duron
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D060825:Cognitive Dysfunction / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I
keywords: Alzheimer’s disease; cognitive decline; insulin-like growth factor-I