title: Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system?
abstract: Acute regulation of adrenocorticotropic hormone (ACTH) in cerebrospinal fluid (CSF) by the hypothalamic-pituitary-adrenocortical system has not been investigated in man. In a pilot study in healthy male volunteers we measured ACTH every twenty minutes in serial CSF for three hours after an intravenous placebo, hydrocortisone (100mg) or insulin (2mg/kg) injection. No acute inhibitory or stimulatory effects of these interventions were discovered. Our results corroborate previous findings in rhesus monkeys. The regulation of CSF ACTH and its potential relevance for behavioral alterations in health and disease (e.g. major depression or anorexia nervosa) in humans need further study.
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany; Medical Park Chiemseeblick, Department of Psychosomatics and Psychotherapy, Rasthausstrasse 25, D-83233 Bernau-Felden, Germany. Electronic address: kellner@uke.uni-hamburg.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Kellner
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany.
authors.forename: Viola
authors.initials: V
authors.lastname: Wortmann
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Anesthesiology, Hamburg, Germany.
authors.forename: Cornelie
authors.initials: C
authors.lastname: Salzwedel
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Anesthesiology, Hamburg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kober
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Anesthesiology, Hamburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Petzoldt
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Urbanowicz
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany.
authors.forename: Mersija
authors.initials: M
authors.lastname: Pulic
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Boelmans
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Yassouridis
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Wiedemann
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000134:cerebrospinal fluid* / Q000187:drug effects; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D064368:Healthy Volunteers; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism*; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010865:Pilot Projects; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D007004:Hypoglycemic Agents; D007328:Insulin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
keywords: ACTH; CSF; Cortisol; Insulin