title: Institutional Animal Care and Use Committee Considerations Regarding the Use of Virus-Induced Carcinogenesis and Oncolytic Viral Models.
abstract: The use of virus-induced carcinogenesis and oncologic experimental animal models is essential in understanding the mechanisms of cancer development to advance prevention, diagnosis, and treatment methods. The Institutional Animal Care and Use Committee (IACUC) is responsible for both the complex philosophical and practical considerations associated with animal models of cancer. Animal models of cancer carry their own unique issues that require special consideration from the IACUC. Many of the considerations to be discussed apply to cancer models in general; specific issues related to viral carcinogenesis or oncolytic viruses will be specifically discussed as they arise. Responsible animal use integrates good science, humane care, and regulatory compliance. To meet those standards, the IACUC, in conjunction with the research investigator and attending veterinarian, must address a wide range of issues, including animal model selection, cancer model selection, humane end point considerations, experimental considerations, postapproval monitoring, reporting requirements, and animal management and personnel safety considerations.
authors.affiliation: Stephanie D. Lewis, DVM, MS, DACLAM, is an associate professor and clinical veterinarian for University Laboratory Animal Resources at The Ohio State University in Columbus, Ohio. Judy M. Hickman-Davis, DVM, PhD, DACLAM, is a professor and clinical veterinarian for University Laboratory Animal Resources at The Ohio State University in Columbus, Ohio. Valerie K. Bergdall, DVM, DACLAM, is a professor and Director of University Laboratory Animal Resources and attending veterinarian at The Ohio State University in Columbus, Ohio.
authors.forename: Stephanie D
authors.initials: SD
authors.lastname: Lewis
authors.affiliation: Stephanie D. Lewis, DVM, MS, DACLAM, is an associate professor and clinical veterinarian for University Laboratory Animal Resources at The Ohio State University in Columbus, Ohio. Judy M. Hickman-Davis, DVM, PhD, DACLAM, is a professor and clinical veterinarian for University Laboratory Animal Resources at The Ohio State University in Columbus, Ohio. Valerie K. Bergdall, DVM, DACLAM, is a professor and Director of University Laboratory Animal Resources and attending veterinarian at The Ohio State University in Columbus, Ohio.
authors.forename: Judy M
authors.initials: JM
authors.lastname: Hickman-Davis
authors.affiliation: Stephanie D. Lewis, DVM, MS, DACLAM, is an associate professor and clinical veterinarian for University Laboratory Animal Resources at The Ohio State University in Columbus, Ohio. Judy M. Hickman-Davis, DVM, PhD, DACLAM, is a professor and clinical veterinarian for University Laboratory Animal Resources at The Ohio State University in Columbus, Ohio. Valerie K. Bergdall, DVM, DACLAM, is a professor and Director of University Laboratory Animal Resources and attending veterinarian at The Ohio State University in Columbus, Ohio.
authors.forename: Valerie K
authors.initials: VK
authors.lastname: Bergdall
mesh_terms: D035661:Animal Care Committees; D000818:Animals; D063646:Carcinogenesis; D004195:Disease Models, Animal; D006801:Humans; D009369:Neoplasms / Q000628:therapy* / Q000821:virology*; D050130:Oncolytic Virotherapy
keywords: Institutional Animal Care and Use Committee (IACUC); animal welfare; cancer models; experimental and humane end points