title: Y-box-binding protein 1 promotes tumor progression and inhibits cisplatin chemosensitivity in esophageal squamous cell carcinoma.
abstract: Y-box-binding protein 1 (YB-1) has been identified as a pleotropic oncoprotein in multiple human malignancies and is involved in the regulation of various DNA/RNA-dependent events, including transcription and translation. However, little is known about expression pattern and underlying functions of YB-1 in esophageal squamous cell carcinoma (ESCC). In this study, we report that up-regulated YB-1 is closely correlated with TNM stage and tumor size in ESCC specimens and predicts a poor prognosis in ESCC patients. Genetic silencing of YB-1 inhibits cell proliferation and invasive potential by regulating its targeted genes associated with tumor growth and metastasis. In particular, we also show that silencing of YB-1 enhances chemotherapy-induced cytotoxicity in EC109 and TE-1 cells by targeting multidrug resistance 1 (MDR1). Our findings demonstrate the oncogenic roles of YB-1 in ESCC and support it as a target for ESCC therapy.
authors.affiliation: Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210000 PR China; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210000 PR China. Electronic address: hzd8124@sina.com.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Hu
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D018450:Disease Progression; D015536:Down-Regulation / Q000187:drug effects; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D020868:Gene Silencing / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D051840:Y-Box-Binding Protein 1 / Q000235:genetics / Q000378:metabolism*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D051840:Y-Box-Binding Protein 1; D002945:Cisplatin
keywords: Drug resistance; Esophageal squamous cell carcinoma; Prognosis; Tumor progression; Y-box-binding protein 1