title: Expression and significance of ERβ and TrkB in endometriosis.
abstract: OBJECTIVE
  To study the potential pathogenesis of endometriosis (EMs) in an area of estrogen receptors (ERs) and tyrosine kinase receptor type B (TrkB) expressions in tissues from patients with EMs.
  
  
  METHODS
  The authors examined the expressions of ERα, ERβ, TrkB, brain-derived neurotrophic factor (BDNF), and SGPL1 in tissues with EMs, using real-time PCR, western blot, and immunohistochemistry.
  
  
  RESULTS
  ERα and SGPL1 were mainly expressed in eutopic endometrium than that in ectopic endometrium of patients with ovarian endometriosis (p < 0.05), while ERβ, BDNF, and TrkB were adverse, mainly detected in ectopic endometrium of the same patients with EMs (p < 0.01 and p < 0.05 ) by real-time PCR and western blot. ERβ, ERα, TrkB, and SGPL1 proteins were mainly expressed in eutopic endometrium of proliferative phase with EMs than that in eutopic endometrium of secretory phase (p < 0.05 ). TrkB, BDNF, and SGPL1 were not found in endometrium of proliferative or secretory phase in control group.
  
  
  CONCLUSIONS
  ERβ expressed in cytoplasm may mediate pathogenesis of EMs.
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: H
authors.initials: H
authors.lastname: Ren
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Yong
authors.forename: H
authors.initials: H
authors.lastname: Zhong
mesh_terms: D015153:Blotting, Western; D004715:Endometriosis / Q000235:genetics* / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D012313:RNA / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020813:Receptor, trkB / Q000096:biosynthesis / Q000235:genetics*; D014591:Uterine Diseases / Q000235:genetics* / Q000378:metabolism
chemical_list: D047629:Estrogen Receptor beta; D012313:RNA; D020813:Receptor, trkB