title: Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats.
abstract: Paecilomyces hepiali is a fungus widely used in Asian countries for various potential pharmacological activities. The present study aims to evaluate the antidiabetic and antinephritic effects of the Paecilomyces hepiali mycelium water extract (PHC) in diabetic rat, which is established by eight-week high-fat diet administration followed by one-week tail intravenous injection of 25 mg/kg streptozotocin (STZ). After four-week 0.12 g/kg metformin and PHC at doses of 0.08, 0.4, and 2.0 g/kg treatment, an increment of body weight, a decrement of plasma glucose, low levels of total cholesterol, and low density lipoprotein cholesterol in diabetic rats were observed. PHC promotes glucose metabolism by enhancing insulin, pyruvate kinase activity, and increasing the synthesis of glycogen. PHC normalized the disturbed levels of superoxide dismutase, methane dicarboxylic aldehyde, and glutathione peroxidase in kidney. The inhibitory effects on the levels of interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor-α in serum and kidney revealed the protection of PHC against diabetic nephropathy. Compared with nontreated diabetic rats, four-week PHC treatment resulted in a decrement on nuclear factor kappa B expression in kidney. These results show that Paecilomyces hepiali possesses antidiabetic and antinephritic effects which are related to the modulation of nuclear factor kappa B activity.
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Teng
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Yange
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Wenji
authors.initials: W
authors.lastname: Hu
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Chen
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Hu
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Yingwu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Di
authors.identifier: 0000-0002-7322-4174
authors.initials: D
authors.lastname: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010143:Paecilomyces; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D012997:Solvents / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D018836:Inflammation Mediators; D008055:Lipids; D016328:NF-kappa B; D012997:Solvents; D014867:Water