title: Regulated cell death and adaptive stress responses.
abstract: Eukaryotic cells react to potentially dangerous perturbations of the intracellular or extracellular microenvironment by activating rapid (transcription-independent) mechanisms that attempt to restore homeostasis. If such perturbations persist, cells may still try to cope with stress by activating delayed and robust (transcription-dependent) adaptive systems, or they may actively engage in cellular suicide. This regulated form of cell death can manifest with various morphological, biochemical and immunological correlates, and constitutes an ultimate attempt of stressed cells to maintain organismal homeostasis. Here, we dissect the general organization of adaptive cellular responses to stress, their intimate connection with regulated cell death, and how the latter operates for the preservation of organismal homeostasis.
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France. deadoc@vodafone.it.|U1138, INSERM, 75006, Paris, France. deadoc@vodafone.it.|Sorbonne Paris Cité, Université Paris Descartes/Paris V, 75006, Paris, France. deadoc@vodafone.it.|Université Pierre et Marie Curie/Paris VI, 75006, Paris, France. deadoc@vodafone.it.|Gustave Roussy Comprehensive Cancer Institute, 94805, Villejuif, France. deadoc@vodafone.it.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France.|U1138, INSERM, 75006, Paris, France.|Sorbonne Paris Cité, Université Paris Descartes/Paris V, 75006, Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006, Paris, France.|Gustave Roussy Comprehensive Cancer Institute, 94805, Villejuif, France.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Bravo-San Pedro
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France.|U1138, INSERM, 75006, Paris, France.|Sorbonne Paris Cité, Université Paris Descartes/Paris V, 75006, Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006, Paris, France.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805, Villejuif, France.
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France. kroemer@orange.fr.|U1138, INSERM, 75006, Paris, France. kroemer@orange.fr.|Sorbonne Paris Cité, Université Paris Descartes/Paris V, 75006, Paris, France. kroemer@orange.fr.|Université Pierre et Marie Curie/Paris VI, 75006, Paris, France. kroemer@orange.fr.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805, Villejuif, France. kroemer@orange.fr.|Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, 75015, Paris, France. kroemer@orange.fr.|Department of Women's and Children's Health, Karolinska University Hospital, 17176, Stockholm, Sweden. kroemer@orange.fr.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology; D009336:Necrosis / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology*
keywords: Apoptosis; Autophagy; Ferroptosis; Mitochondrial permeability transition; Necroptosis