title: Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings.
abstract: CONCLUSIONS
  In Kikuchi-Fujimoto disease (KFD), a low ratio of blastic cells (<70%) in lymph node specimens and absence of atypical lymphocytes in peripheral blood are predictive of a protracted clinical course.
  
  
  OBJECTIVE
  Since KFD is a self-limiting disorder that does not require any specific management, prognostic factors have received little attention. The present study identified clinical and pathological factors that may affect the period from onset to cure of KFD.
  
  
  METHODS
  This retrospective study investigated 43 KFD patients who underwent lymph node biopsy diagnosed by immunohistochemical staining at Okayama University Hospital and Okayama Medical Center from January 2001 to December 2013.
  
  
  RESULTS
  Mean total period from onset to cure was 6 months (median =9.4 months; range =1-37 months). Low ratios of blastic cell proliferation area (<70%) in lymph node specimens (p = 0.011) and absence of atypical lymphocytes in peripheral blood (p = 0.026) were associated with a relatively long duration of KFD.
authors.affiliation: a Department of Otolaryngology Head and Neck Surgery , National Hospital Organization Okayama Medical Center , Okayama , Japan ;
authors.forename: Hidenori
authors.initials: H
authors.lastname: Marunaka
authors.affiliation: b Department of Otolaryngology Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan ;
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Orita
authors.affiliation: c Department of Otolaryngology Head and Neck Surgery , Himeji Red Cross Hospital , Hyogo , Japan ;
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Tachibana
authors.affiliation: b Department of Otolaryngology Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan ;
authors.forename: Kentaro
authors.initials: K
authors.lastname: Miki
authors.affiliation: c Department of Otolaryngology Head and Neck Surgery , Himeji Red Cross Hospital , Hyogo , Japan ;
authors.forename: Takuma
authors.initials: T
authors.lastname: Makino
authors.affiliation: d Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan ;
authors.forename: Yuka
authors.initials: Y
authors.lastname: Gion
authors.affiliation: b Department of Otolaryngology Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan ;
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
authors.affiliation: d Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan ;
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.affiliation: d Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan ;|e Division of Pathophysiology , Okayama University Graduate School of Health Sciences , Okayama , Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: Kikuchi-Fujimoto disease; atypical lymphocytes; blastic cell; prognostic factors