title: An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification.
abstract: In this work, an electrochemical peptide biosensor was developed for matrix metalloproteinase-2 (MMP-2) detection by conversion of a peptide cleavage event into DNA detection with exonuclease III (Exo III)-assisted cycling signal amplification.
authors.affiliation: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China. yqchai@swu.edu.cn yuanruo@swu.edu.cn.
authors.forename: Ding
authors.initials: D
authors.lastname: Wang
authors.forename: Yali
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yingning
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Chai
authors.forename: Ruo
authors.initials: R
authors.lastname: Yuan
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004563:Electrochemistry; D005090:Exodeoxyribonucleases / Q000378:metabolism*; D006046:Gold / Q000737:chemistry; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D053768:Metal Nanoparticles / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011137:Polystyrenes / Q000737:chemistry; D059748:Proteolysis
chemical_list: D010455:Peptides; D011137:Polystyrenes; D006046:Gold; D004247:DNA; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III; D020778:Matrix Metalloproteinase 2