title: Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome.
abstract: This review covers recent discoveries of phytoconstituents, herbal extracts and some semi-synthetic compounds for treating metabolic syndrome with AMPK activation as one of their mechanisms of action. Recent researches have demonstrated AMPK activation to ameliorate multiple components of metabolic syndrome by regulating a balance between anabolic and catabolic cellular reactions. The review attempts to delineate the AMPK activation by natural agents from the perspective of its functional consequences on enzymes, transcription factors and signaling molecules and also on other potential factors contributing in the amelioration of metabolic syndrome.
authors.affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India.
authors.forename: Hitender
authors.initials: H
authors.lastname: Sharma
authors.affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D001688:Biological Products; D055372:AMP-Activated Protein Kinases
keywords: Cardiovascular disorders; diabetes; metabolic syndrome; obesity; phytoconstituents; transcription factors