title: Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model.
abstract: Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study, the effects of topical curcumin treatment on radiation burns were evaluated in a mini-pig model. Histological and clinical changes were observed five weeks after radiation exposure to the back (⁶⁰Co gamma-radiation, 50 Gy). Curcumin was applied topically to irradiated skin (200 mg/cm²) twice a day for 35 days. Curcumin application decreased the epithelial desquamation after irradiation. Additionally, when compared to the vehicle-treated group, the curcumin-treated group showed reduced expression of cyclooxygenase-2 and nuclear factor-kappaB. Furthermore, irradiation prolonged healing of biopsy wounds in the exposed area, whereas curcumin treatment stimulated wound healing. These results suggest that curcumin can improve epithelial cell survival and recovery in the skin and therefore be used to treat radiation burns.
authors.affiliation: Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.|Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 46033, Korea.
authors.forename: Joongsun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
authors.forename: Sunhoo
authors.initials: S
authors.lastname: Park
authors.affiliation: Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
authors.forename: Byung-Suk
authors.initials: BS
authors.lastname: Jeon
authors.affiliation: Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Jang
authors.affiliation: Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
authors.forename: Sun-Joo
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 46033, Korea.
authors.forename: Yeonghoon
authors.initials: Y
authors.lastname: Son
authors.affiliation: Department of Dermatology, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Rhim
authors.affiliation: College of Oriental Medicine, Dongshin Univiersity, Naju 58245, Korea.
authors.forename: Soong In
authors.initials: SI
authors.lastname: Lee
authors.affiliation: Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
authors.forename: Seung-Sook
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000188:drug therapy*; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use*; D005720:Gamma Rays / Q000009:adverse effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects / Q000528:radiation effects*; D013552:Swine; D013556:Swine, Miniature; D014945:Wound Healing / Q000187:drug effects* / Q000235:genetics
chemical_list: D011837:Radiation-Protective Agents; D003474:Curcumin
keywords: curcumin; mini-pig; radiation burns; skin