title: Weight Loss Associated with Platinum-Based Chemotherapy in Patients with Advanced Lung Cancer.
abstract: BACKGROUND
  We examined whether the weight loss that occurs with platinum-based chemotherapy in lung cancer patients is associated with chemotherapy side effects, treatment completion rates and therapeutic effect.
  
  
  METHODS
  We retrospectively reviewed charts of advanced lung cancer patients treated with ≥2 cycles of platinum-based chemotherapy. Patients were divided into 2 groups based on ≥5 or <5% weight loss. Relationships between weight loss and other variables were investigated.
  
  
  RESULTS
  Among 114 patients, 18 (15.8%) experienced ≥5% weight loss. Significantly more patients with small-cell lung cancer (SCLC) than with non-SCLC were found to have ≥5% weight loss (30.8 vs. 11.4%, p = 0.023). Patients with ≥5% weight loss experienced higher incidences of grade 3-4 leukopenia (p = 0.008) and neutropenia (p = 0.005), and treatment completion rates were lower in this group (p = 0.035). Weight loss was not significantly associated with therapeutic effect.
  
  
  CONCLUSIONS
  The weight loss in patients with advanced lung cancer receiving platinum-based chemotherapy is associated with SCLC, grade 3-4 leukopenia, neutropenia and a decrease in treatment completion rate.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Morio
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Minami
authors.forename: Takashi
authors.initials: T
authors.lastname: Sozu
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Niki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kijima
authors.forename: Etsuko
authors.initials: E
authors.lastname: Uejima
authors.forename: Kayoko
authors.initials: K
authors.lastname: Morio
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D016015:Logistic Models; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009503:Neutropenia / Q000209:etiology; D010984:Platinum / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D018906:Antineoplastic Agents, Alkylating; D010984:Platinum