title: High population attributable fractions of myocardial infarction associated with waist-hip ratio.
abstract: To estimate population attributable fractions (PAF) of acute myocardial infarction (AMI) associated with anthropometric measures by sex and age.
  
  
  
  The Cohort of Norway study identified 140,790 participants free of cardiovascular disease, 1994-2003. Participants were followed for AMI through 2009 by record linkages through the Cardiovascular Disease in Norway Project. PAFs were adjusted for age, smoking, systolic blood pressure, diabetes, and the ratio of total cholesterol to high-density lipoprotein cholesterol.
  
  
  
  The PAFs associated with a waist-hip ratio (WHR) in the top two quintiles were 26.1% (95% confidence interval, CI 14.6-36.1) for middle-aged women (<60 years, mean of 41 years) and 9.3% (95% CI 3.0-15.1) for similarly aged men after adjustment for body mass index (BMI) and conventional risk factors. However, PAFs associated with anthropometric measures in elderly participants (≥ 60 years, mean of 70 years) were non-significant in multivariable analyses. Also, WHR was a significant predictor of AMI among men and women without an enlarged waist circumference (<102 cm for men and < 88 cm for women) in adjusted analyses.
  
  
  
  WHR measurements could improve identification of at-risk individuals above and beyond that of conventional risk factors, BMI, or an enlarged waist circumference.
authors.affiliation: Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.|Division of Epidemiology, Department of Health Registries, Norwegian Institute of Public Health, Bergen, Norway.
authors.forename: Grace M
authors.initials: GM
authors.lastname: Egeland
authors.affiliation: Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
authors.forename: Jannicke
authors.initials: J
authors.lastname: Igland
authors.affiliation: Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.|Division of Epidemiology, Department of Health Registries, Norwegian Institute of Public Health, Bergen, Norway.
authors.forename: Stein Emil
authors.initials: SE
authors.lastname: Vollset
authors.affiliation: Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.|Division of Epidemiology, Department of Health Registries, Norwegian Institute of Public Health, Bergen, Norway.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Sulo
authors.affiliation: Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.|Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.
authors.forename: Geir Egil
authors.initials: GE
authors.lastname: Eide
authors.affiliation: Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.|Division of Epidemiology, Department of Health Registries, Norwegian Institute of Public Health, Bergen, Norway.
authors.forename: Grethe S
authors.initials: GS
authors.lastname: Tell
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol; D008076:Cholesterol, HDL; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D009664:Norway / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D008076:Cholesterol, HDL; D002784:Cholesterol