title: Use of leukocyte and platelet-rich fibrin (L-PRF) in periodontally accelerated osteogenic orthodontics (PAOO): Clinical effects on edema and pain.
abstract: BACKGROUND
  Demand for shorter treatment time is common in orthodontic patients. Periodontally Accelerated Osteogenic Orthodontics (PAOO) is a somewhat new surgical procedure which allows faster tooth movement via combining orthodontic forces with corticotomy and grafting of alveolar bone plates. Leukocyte and Platelet-Rich Fibrin (L-PRF) possess hard- and soft-tissue healing properties. Further, evidence of pain-inhibitory and anti-inflammatory potential is growing. Therefore, this study explores the feasibility, intra- and post-operative effects of using L-PRF in PAOO in terms of post-operative pain, inflammation, infection and post-orthodontic stability.
  
  
  METHODS
  A pilot prospective observational study involving a cohort of 11 patients was carried out. A Wilcko's modified PAOO technique with L-PRF (incorporated into the graft and as covering membrane) was performed with informed consent. Post-surgical pain, inflammation and infection were recorded for 10 days post-operatively, while the overall orthodontic treatment and post-treatment stability were followed up to 2 years.
  
  
  RESULTS
  Accelerated wound healing with no signs of infection or adverse reactions was evident. Post-surgical pain was either "mild" (45.5%) or "moderate" (54.5%). Immediate post-surgical inflammation was either "mild" (89.9%) or "moderate" (9.1%). Resolution began on day 4 where most patients experienced either "mild" or no inflammation (72.7% and 9.1%, respectively). Complete resolution was achieved in all patients by day 8. The average orthodontic treatment time was 9.3 months. All cases were deemed stable for 2 years.
  
  
  CONCLUSIONS
  L-PRF is simple and safe to use in PAOO. Combination with traditional bone grafts potentially accelerates wound healing and reduces post-surgical pain, inflammation, infection without interfering with tooth movement and/or post-orthodontic stability, over a 2 years period; thus alleviating the need for analgesics and anti-inflammatory medications.
  
  
  BACKGROUND
  Periodontally accelerated osteogenic orthodontics, leukocyte and platelet-rich fibrin, corticotomy, osteogenesis, grafts.
authors.affiliation: DDS, certified Oral and MaxilloFacial Surgeon, Professor, Faculty of Dentistry, Universidad de los Andes, Santiago, Chile.
authors.forename: Francisco
authors.initials: F
authors.lastname: Munoz
authors.affiliation: DDS, certified Periodontist and Implantologist, BioMAT'X- Centro de Investigación Biomédica (CIB), Faculty of Dentistry, Universidad de los Andes, Santiago, Chile.
authors.forename: Constanza
authors.initials: C
authors.lastname: Jiménez
authors.affiliation: DDS, Oral and MaxilloFacial Surgeon, BioMAT'X- Centro de Investigación Biomédica (CIB), Faculty of Dentistry, Universidad de los Andes, Santiago, Chile.
authors.forename: Daniela
authors.initials: D
authors.lastname: Espinoza
authors.affiliation: DDS, certified Oral and Maxillofacial Surgeon, (BioMAT'X-CIB UAndes Consultant), Private practice, Marseille, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Vervelle
authors.affiliation: DDS, certified Orthodontist, (BioMAT'X-CIB UAndes Consultant), Private practice, Marseille, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Beugnet
authors.affiliation: DDS, certified Implantologist, Oral and Maxillofacial Surgeon (M.Sc.), M.B.A., PhD. Professor and Scientific Director, Faculty of Dentistry, UAndes. Founder and Head of BioMAT'X-CIB-PMI (Plan de Mejoramiento Institucional en Innovación), Universidad de los Andes, Santiago, Chile.
authors.forename: Ziyad
authors.initials: Z
authors.lastname: Haidar