title: Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk.
abstract: Previous studies on the association of parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) with childhood leukemia risk have produced inconsistent results. To reevaluate this association, we performed a meta-analysis by pooling 11 case-control and one cohort studies. The overall results showed that neither maternal nor paternal occupational exposure was associated with childhood leukemia risk. For paternal occupational exposure, significant association was found when pooling studies with small number of cases (OR =1.96; 95% CI, 1.03-3.74) or with lower quality score (OR =1.52; 95% CI, 1.07-2.15). However, this association was not confirmed when pooling studies with large number of cases or high quality score. In conclusion, our data indicate no association between parental occupational ELF-MF exposure and childhood leukemia risk, and the elevated OR under certain subgroup analysis is likely due to chance. Further studies with precise ELF-MF exposure assessment are suggested.
authors.affiliation: a Bioelectromagnetics Laboratory , Zhejiang University School of Medicine , Hangzhou , China.|b Institute of Environmental Health, Department of Public Health , Zhejiang University School of Medicine , Hangzhou , China.
authors.forename: Liling
authors.initials: L
authors.lastname: Su
authors.affiliation: a Bioelectromagnetics Laboratory , Zhejiang University School of Medicine , Hangzhou , China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Fei
authors.affiliation: a Bioelectromagnetics Laboratory , Zhejiang University School of Medicine , Hangzhou , China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Wei
authors.affiliation: a Bioelectromagnetics Laboratory , Zhejiang University School of Medicine , Hangzhou , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: c Department of Data Management , Zhejiang Center for Disease Control and Prevention , Hangzhou , China.
authors.forename: Xiangen
authors.initials: X
authors.lastname: Jiang
authors.affiliation: d Department of Oncology , Zhejiang Provincial People's Hospital , Hangzhou , China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Lu
authors.affiliation: a Bioelectromagnetics Laboratory , Zhejiang University School of Medicine , Hangzhou , China.|b Institute of Environmental Health, Department of Public Health , Zhejiang University School of Medicine , Hangzhou , China.
authors.forename: Guangdi
authors.initials: G
authors.lastname: Chen
mesh_terms: D000367:Age Factors; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology*; D060526:Magnetic Fields / Q000009:adverse effects*; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017594:Publication Bias; D012306:Risk
keywords: Childhood leukemia; ELF-MF; meta-analysis; parental occupational exposure