title: Cutaneous Human Polyomavirus Small T Antigens and 4E-BP1 Targeting.
abstract: Merkel cell polyomavirus (MCPyV), trichodysplasia spinulosa-associated polyomavirus (TSPyV), human polyomavirus 6 (HPyV6), and human polyomavirus 7 (HPyV7) are implicated in the pathogeneses of distinct hyperproliferative cutaneous growths and encode small tumor (sT) antigens. The current study demonstrates that the four sT antigens differentially regulate 4E-binding protein 1 (4E-BP1) serine 65 hyperphosphorylation. MCPyV and HPyV7 sT antigens were found to promote the presence of the hyperphosphorylated 4E-BP1-δ isoform, while TSPyV and HPyV6 sT antigens had no significant effects. Given that hyperphosphorylated 4E-BP1 is associated with an aggressive cancer phenotype, our findings confirm the previously reported pathogenicity of MCPyV sT and highlight a novel mechanism by which HPyV7 sT may mediate oncogenesis.
authors.affiliation: Department of Dermatology, University of Texas Medical School at Houston, Houston, Tex., USA.
authors.forename: Julie H
authors.initials: JH
authors.lastname: Wu
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Simonette
authors.forename: Thomas
authors.initials: T
authors.lastname: Hsiao
authors.forename: Hung Q
authors.initials: HQ
authors.lastname: Doan
authors.forename: Peter L
authors.initials: PL
authors.lastname: Rady
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Tyring
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000952:Antigens, Polyomavirus Transforming / Q000276:immunology*; D018797:Cell Cycle Proteins; D006801:Humans; D059965:Merkel cell polyomavirus / Q000276:immunology*; D010750:Phosphoproteins / Q000235:genetics*; D027382:Polyomaviridae / Q000276:immunology*; D011120:Polyomavirus / Q000276:immunology*; D027601:Polyomavirus Infections / Q000276:immunology* / Q000821:virology; D012878:Skin Neoplasms / Q000821:virology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000952:Antigens, Polyomavirus Transforming; D018797:Cell Cycle Proteins; C087000:EIF4EBP1 protein, human; D010750:Phosphoproteins