title: Evolution of Schooling Behavior in Threespine Sticklebacks Is Shaped by the Eda Gene.
abstract: Despite longstanding interest in the genetic mechanisms that underlie behavioral evolution, very few genes that underlie naturally occurring variation in behavior between individuals or species are known, particularly in vertebrates. Here, we build on our previous forward genetic mapping experiments and use transgenic approaches to identify Ectodysplasin as a gene that causes differences in schooling behavior between wild populations of threespine stickleback (Gasterosteus aculeatus) fish. This work provides rare insight into the proximate mechanisms that have shaped the evolution of vertebrate behavior.
authors.affiliation: Divisions of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Greenwood
authors.affiliation: Divisions of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195.
authors.forename: Margaret G
authors.initials: MG
authors.lastname: Mills
authors.affiliation: Divisions of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195.
authors.forename: Abigail R
authors.initials: AR
authors.lastname: Wark
authors.affiliation: Divisions of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195.
authors.forename: Sophie L
authors.initials: SL
authors.lastname: Archambeault
authors.affiliation: Divisions of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 cpeichel@fhcrc.org.
authors.forename: Catherine L
authors.identifier: 0000-0002-7731-8944
authors.initials: CL
authors.lastname: Peichel
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D019143:Evolution, Molecular; D029941:Fish Proteins / Q000235:genetics* / Q000378:metabolism; D014644:Genetic Variation; D007858:Learning; D023701:Smegmamorpha / Q000235:genetics* / Q000502:physiology
chemical_list: D029941:Fish Proteins
keywords: genetics of behavioral evolution; natural variation; schooling behavior; threespine stickleback; transgenic