title: A computational simulation of the effect of hybrid treatment for thoracoabdominal aortic aneurysm on the hemodynamics of abdominal aorta.
abstract: Hybrid visceral-renal debranching procedures with endovascular repair have been proposed as an appealing technique to treat conventional thoracoabdominal aortic aneurysm (TAAA). This approach, however, still remained controversial because of the non-physiological blood flow direction of its retrograde visceral revascularization (RVR) which is generally constructed from the aortic bifurcation or common iliac artery. The current study carried out the numerical simulation to investigate the effect of RVR on the hemodynamics of abdominal aorta. The results indicated that the inflow sites for the RVR have great impact on the hemodynamic performance. When RVR was from the distal aorta, the perfusion to visceral organs were adequate but the flow flux to the iliac artery significantly decreased and a complex disturbed flow field developed at the distal aorta, which endangered the aorta at high risk of aneurysm development. When RVR was from the right iliac artery, the abdominal aorta was not troubled with low WSS or disturbed flow, but the inadequate perfusion to the visceral organs reached up to 40% and low WSS and flow velocity predominated appeared at the right iliac artery and the grafts, which may result in the stenosis in grafts and aneurysm growth on the host iliac artery.
authors.affiliation: School of Civil Engineering and Architecture, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wen
authors.affiliation: Vascular Surgery Department of West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Department of Applied Mechanics, Sichuan University, Chengdu, 610065, China.
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Vascular Surgery Department of West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Jichun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Applied Mechanics, Sichuan University, Chengdu, 610065, China.
authors.forename: Tinghui
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, P. R. China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
mesh_terms: D017130:Angioplasty / Q000379:methods*; D001012:Aorta, Abdominal / Q000473:pathology / Q000601:surgery; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000473:pathology / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D008953:Models, Anatomic