title: Breast Cancer Trend in Iran from 2000 to 2009 and Prediction till 2020 using a Trend Analysis Method.
abstract: BACKGROUND
  Breast cancer is the most common cancer in women worldwide with a rising incidence rate in most countries. Considering the increase in life expectancy and change in lifestyle of Iranian women, this study investigated the age-adjusted trend of breast cancer incidence during 2000-2009 and predicted its incidence to 2020.
  
  
  METHODS
  The 1997 and 2006 census results were used for the projection of female population by age through the cohort-component method over the studied years. Data from the Iranian cancer registration system were used to calculate the annual incidence rate of breast cancer. The age-adjusted incidence rate was then calculated using the WHO standard population distribution. The five-year-age-specific incidence rates were also obtained for each year and future incidence was determined using the trend analysis method. Annual percentage change (APC) was calculated through the joinpoint regression method.
  
  
  RESULTS
  The bias adjusted incidence rate of breast cancer increased from 16.7 per 100,000 women in 2000 to 33.6 per 100,000 women in 2009. The incidence of breast cancer had a growing trend in almost all age groups above 30 years over the studied years. In this period, the age groups of 45-65 years had the highest incidence. Investigation into the joinpoint curve showed that the curve had a steep slope with an APC of 23.4% before the first joinpoint, but became milder after this. From 2005 to 2009, the APC was calculated as 2.7%, through which the incidence of breast cancer in 2020 was predicted as 63.0 per 100,000 women.
  
  
  CONCLUSIONS
  The age-adjusted incidence rate of breast cancer continues to increas in Iranian women. It is predicted that this trend will continue until 2020. Therefore, it seems necessary to prioritize the prevention, control and care for breast cancer in Iran.
authors.affiliation: Pathology Department, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran E-mail : rezachaman@yahoo.com.
authors.forename: Bibihajar
authors.initials: B
authors.lastname: Zahmatkesh
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Keramat
authors.forename: Nasrinossadat
authors.initials: N
authors.lastname: Alavi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Khosravi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Kousha
authors.forename: Ali Ghanbari
authors.initials: AG
authors.lastname: Motlagh
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Darman
authors.forename: Elham
authors.initials: E
authors.lastname: Partovipour
authors.forename: Reza
authors.initials: R
authors.lastname: Chaman
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D008017:Life Expectancy; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D012044:Regression Analysis; D012424:Rural Population / Q000706:statistics & numerical data*; D013997:Time Factors; D014505:Urban Population / Q000706:statistics & numerical data*; D055815:Young Adult