title: Significance of TNF-α and IL-6 expression in invasive pituitary adenomas.
abstract: The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found to be upregulated in IPA tissue compared with that of NIPA (P < 0.05). These proteins may therefore play important roles in the occurrence and progression of IPA.
authors.affiliation: Department of Pathology, Chengde City Center Hospital, Shuangqiao District, Guangren, Chengde, Hebei, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Chengde City Center Hospital, Shuangqiao District, Guangren, Chengde, Hebei, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Qiao
authors.affiliation: Department of Pathology, Chengde City Center Hospital, Shuangqiao District, Guangren, Chengde, Hebei, China.
authors.forename: Q H
authors.initials: QH
authors.lastname: Duan
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha