title: Protein profiling of alpha-fetoprotein producing gastric adenocarcinoma.
abstract: Alpha-fetoprotein (AFP) producing gastric adenocarcinoma is considered as a rare subtype of gastric adenocarcinoma. Compared with AFP non-producing gastric adenocarcinoma, our study and other previous studies showed that AFP producing gastric adenocarcinoma is more aggressive and prone to liver metastasis. Using the Protein Pathway Array, 11 of out of 286 proteins tested were found to be differentially expressed between AFP producing (n=32) and AFP non-producing (n=45) gastric adenocarcinoma tissues. In addition, the high level expression of XIAP and IGF-Irβ in gastric adenocarcinoma tissues was independent factors for poor prognosis in AFP producing gastric adenocarcinoma patients. A risk model based on the XIAP and IGF-Irβ expression levels can separate AFP producing gastric adenocarcinoma patients into 2 subgroups and each subgroup had a distinct set of signaling pathways involved. In conclusion, AFP producing gastric adenocarcinoma is a heterogeneous cancer with different clinical outcomes, biological behaviors and underlying molecular alterations.
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Liang
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Clinical Laboratory, First Hospital of Jilin University, Changchun, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Qu
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Daguang
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Chengguo
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Lee
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Suo
authors.affiliation: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: David Y
authors.initials: DY
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: C097353:AFP protein, human; D020543:Proteome; D000509:alpha-Fetoproteins
keywords: AFP; gastric cancer; signaling pathways; survival analysis