title: Aggressive Angiomyxoma of the Vulva with No Recurrence on a 5-year Follow up: A Case Report.
abstract: We report a case of vulvar aggressive angiomyxoma (AA) which is a rare, slow growing and benign tumor of mesenchymal origin, but has a high risk of local recurrence. A 49-year-old Japanese female was referred to us with a large mass of the left vulva, measuring 15×9.5×9 centimeters. She underwent surgical excision of the tumor with no evidence of recurrence on a 5-year follow up. In this case, histopathological examination and immunohistochemical staining after excision revealed a diagnosis of vulvar AA with estrogen and progesterone receptors positive. Aggressive angiomyxoma of the vulva needs to be distinguished from benign myxoid tumor with a low risk of local recurrence as well as from malignant neoplasma. The first line treatment of AA is complete surgical excision with tumor free margins, it will reduce the recurrence.
authors.forename: Chisa
authors.initials: C
authors.lastname: Narayama
authors.affiliation: Department of Obstetrics and Gynecology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. ikedam@tokai-u.jp.
authors.forename: Masae
authors.initials: M
authors.lastname: Ikeda
authors.forename: Miwa
authors.initials: M
authors.lastname: Yasaka
authors.forename: Yu-suke
authors.initials: YS
authors.lastname: Sagara
authors.forename: Yasuhira
authors.initials: Y
authors.lastname: Kan-no
authors.forename: Io
authors.initials: I
authors.lastname: Hayashi
authors.forename: Atuya
authors.initials: A
authors.lastname: Narita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Asai
authors.forename: Toshiki
authors.initials: T
authors.lastname: Tajima
authors.forename: Masako
authors.initials: M
authors.lastname: Shida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirasawa
authors.forename: Mikio
authors.initials: M
authors.lastname: Mikami
mesh_terms: D018229:Angiomyoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012306:Risk; D013997:Time Factors; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone