title: Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds.
abstract: Alzheimer's disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-β metabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based compounds in therapeutics.
authors.affiliation: Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Sandeep Kumar
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Srivastav
authors.affiliation: Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Amarish Kumar
authors.initials: AK
authors.lastname: Yadav
authors.affiliation: Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Saripella
authors.initials: S
authors.lastname: Srikrishna
authors.affiliation: Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: George
authors.initials: G
authors.lastname: Perry
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008517:Phytotherapy / Q000379:methods*
chemical_list: D016229:Amyloid beta-Peptides