title: Local and Regional Spread of Primary Conjunctival Squamous Cell Carcinoma.
abstract: Two cases of biopsy-proven conjunctival squamous cell carcinoma (SCC) that developed local and regional spread are described. The cases involved a 65-year-old woman and a 79-year-old man who were initially treated at outside institutions for SCC of the conjunctiva. The patients did not have a history of immune compromise. The female patient presented with direct extension into the lacrimal gland but deferred recommended exenteration. Despite eventual exenteration, she developed metastasis to a neck node 6 months later, which was treated with radiotherapy. The male patient presented with local recurrence and a parotid node metastasis treated with exenteration, parotidectomy, selective neck dissection, and postoperative radiotherapy. Review of the outside pathology of both cases revealed positive tumor margins at the time of original resection. Local control of conjunctival SCC is of critical importance to reduce the risk of orbital extension and regional spread.
authors.affiliation: Department of Ophthalmology (S.J.D., N.L.P., M.J.G., M.M.B., M.R.V.), University of California, San Francisco, CA; Department of Ophthalmology (S.J.D., N.L.P., M.J.G., M.M.B., M.R.V.), San Francisco General Hospital, San Francisco, CA; and Department of Ophthalmology and Visual Sciences (B.H.J.), University of Maryland School of Medicine, Baltimore, MD.
authors.forename: Shilpa J
authors.initials: SJ
authors.lastname: Desai
authors.forename: Noelle L
authors.initials: NL
authors.lastname: Pruzan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Geske
authors.forename: Bennie H
authors.initials: BH
authors.lastname: Jeng
authors.forename: Michele M
authors.initials: MM
authors.lastname: Bloomer
authors.forename: M Reza
authors.initials: MR
authors.lastname: Vagefi
mesh_terms: D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed