title: Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines.
abstract: A small library of 1-aminoalkyl 2-naphthols has been synthesized through the direct Mannich reaction of 2-naphthols with (hetero)aromatic aldehydes and secondary amines. All of the Mannich bases having a thiophen-2-yl ring in their structure had good activity against Gram-positive bacteria, irrespective of the nature of the amino moiety.
authors.affiliation: Petru Poni Institute of Macromolecular Chemistry, 41A Aleea Gr. Ghica Vodă, Iaşi 700487, Romania. Electronic address: gheorghe.roman@icmpp.ro.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Roman
authors.affiliation: Ion Ionescu de la Brad University, Laboratory of Antimicrobial Chemotherapy, 8 Aleea Sadoveanu, Iaşi 700489, Romania.
authors.forename: Valentin
authors.initials: V
authors.lastname: Năstasă
authors.affiliation: Ion Ionescu de la Brad University, Laboratory of Antimicrobial Chemotherapy, 8 Aleea Sadoveanu, Iaşi 700489, Romania.
authors.forename: Andra-Cristina
authors.initials: AC
authors.lastname: Bostănaru
authors.affiliation: Ion Ionescu de la Brad University, Laboratory of Antimicrobial Chemotherapy, 8 Aleea Sadoveanu, Iaşi 700489, Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Mareş
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008352:Mannich Bases / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009284:Naphthols / Q000737:chemistry; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D008352:Mannich Bases; D009284:Naphthols; D054852:Small Molecule Libraries; C028405:2-naphthol
keywords: Aminomethylation; Antibacterial; MRSA; Mannich base; Thiophene