title: Applying the Airbrakes: Treating Mitochondrial Disease with Hypoxia.
abstract: A paper from Jain et al. (2016) using whole-genome CRISPR knockout libraries in human cells and models of mitochondrial disease suggests chronic hypoxia could be an unexpected treatment for disorders of mitochondrial respiration.
authors.affiliation: Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
authors.forename: Oliver M
authors.initials: OM
authors.lastname: Russell
authors.affiliation: Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Lightowlers
authors.affiliation: Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address: doug.turnbull@newcastle.ac.uk.
authors.forename: Doug M
authors.initials: DM
authors.lastname: Turnbull
mesh_terms: D000818:Animals; D006801:Humans; D007888:Leigh Disease / Q000235:genetics* / Q000628:therapy*; D008928:Mitochondria / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics*
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein; D010100:Oxygen