title: Live high, train low - influence on resting and post-exercise hepcidin levels.
abstract: The post-exercise hepcidin response during prolonged (>2 weeks) hypoxic exposure is not well understood. We compared plasma hepcidin levels 3 h after exercise [6 × 1000 m at 90% of maximal aerobic running velocity (vVO2max)] performed in normoxia and normobaric hypoxia (3000 m simulate altitude) 1 week before, and during 14 days of normobaric hypoxia [196.2 ± 25.6 h (median: 200.8 h; range: 154.3-234.8 h) at 3000 m simulated altitude] in 10 well-trained distance runners (six males, four females). Venous blood was also analyzed for hepcidin after 2 days of normobaric hypoxia. Hemoglobin mass (Hbmass) was measured via CO rebreathing 1 week before and after 14 days of hypoxia. Hepcidin was suppressed after 2 (Cohen's d = -2.3, 95% confidence interval: [-2.9, -1.6]) and 14 days of normobaric hypoxia (d = -1.6 [-2.6, -0.6]). Hepcidin increased from baseline, 3 h post-exercise in normoxia (d = 0.8 [0.2, 1.3]) and hypoxia (d = 0.6 [0.3, 1.0]), both before and after exposure (normoxia: d = 0.7 [0.3, 1.2]; hypoxia: d = 1.3 [0.4, 2.3]). In conclusion, 2 weeks of normobaric hypoxia suppressed resting hepcidin levels, but did not alter the post-exercise response in either normoxia or hypoxia, compared with the pre-exposure response.
authors.affiliation: Institute for Sport & Physical Activity Research, University of Bedfordshire, Bedford, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Govus
authors.affiliation: School of Sport Science, Exercise & Health, University of Western Australia, Crawley, Western Australia, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Peeling
authors.affiliation: Centre for Exercise & Sports Science Research, School of Exercise and Health Science, Edith Cowan University, Joondalup, Western Australia, Australia.
authors.forename: C R
authors.initials: CR
authors.lastname: Abbiss
authors.affiliation: School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia.
authors.forename: N G
authors.initials: NG
authors.lastname: Lawler
authors.affiliation: Department of Laboratory Medicine (TML 830), Radboud University Medical Centre, Nijmegen, The Netherlands.|Hepcidinanalysis.com, Radboudumc, Geert Grooteplein 10 (TML 830), Nijmegen, The Netherlands.
authors.forename: D W
authors.initials: DW
authors.lastname: Swinkels
authors.affiliation: Department of Laboratory Medicine (TML 830), Radboud University Medical Centre, Nijmegen, The Netherlands.|Hepcidinanalysis.com, Radboudumc, Geert Grooteplein 10 (TML 830), Nijmegen, The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Laarakkers
authors.affiliation: Research Institute for Sport & Exercise, University of Canberra, Belconnen, Australian Capital Territory, Australia.
authors.forename: K G
authors.initials: KG
authors.lastname: Thompson
authors.affiliation: School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia.
authors.forename: J J
authors.initials: JJ
authors.lastname: Peiffer
authors.affiliation: Research Institute for Sport & Exercise, University of Canberra, Belconnen, Australian Capital Territory, Australia.|Department of Physiology, Australian Institute of Sport, Bruce, Australian Capital Territory, Australia.|Exercise Physiology Laboratory, Flinders University, Bedford Park, South Australia, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Gore
authors.affiliation: Research Institute for Sport & Exercise, University of Canberra, Belconnen, Australian Capital Territory, Australia.|Department of Physiology, Australian Institute of Sport, Bruce, Australian Capital Territory, Australia.
authors.forename: L A
authors.initials: LA
authors.lastname: Garvican-Lewis
mesh_terms: D000328:Adult; D000531:Altitude; D015444:Exercise / Q000502:physiology*; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D000860:Hypoxia / Q000097:blood; D008297:Male; D010101:Oxygen Consumption; D012146:Rest / Q000502:physiology*; D012420:Running / Q000502:physiology; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D064451:Hepcidins
keywords: Iron metabolism; altitude training; hypoxia; iron deficiency