title: Neuro-protective Mechanisms of Lycium barbarum.
abstract: Neuronal diseases, including retinal disorders, stroke, Alzheimer's disease, Parkinson's disease and spinal cord injury, affect a large number of people worldwide and cause heavy social and economic burdens. Although many efforts have been made by scientists and clinicians to develop novel drug and healthcare strategies, few of them received satisfactory outcomes to date. Lycium barbarum is a traditional homology of medicine and food in Chinese medicine, with the capability to nourish the eyes, liver and kidneys. Recent studies have also explored its powerful neuro-protective effects on a number of neuronal diseases. In the current review, we collected key recent findings regarding the neuro-protective effects and mechanisms of L. barbarum derivatives, primarily its polysaccharide (LBP) , in some common diseases of the nervous system. A comprehensive comparison with currently available drugs has also been discussed. In general, LBP is a promising neuronal protector with potent ameliorative effects on key pathological events, such as oxidative stress, inflammation, apoptosis and cell death with minimal side effects.
authors.affiliation: Department of Biotechnology, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, China.
authors.forename: Xiwen
authors.initials: X
authors.lastname: Xing
authors.affiliation: Department of Biotechnology, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, China.
authors.forename: Fenyong
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, China. tjxiao@jnu.edu.cn.|State Key Discipline of Infectious Diseases, Department of Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, 518112, China. tjxiao@jnu.edu.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Xiao
authors.affiliation: GMH Institute of CNS Regeneration, Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, 510632, China. hrmaskf@hku.hk.|Department of Ophthalmology, State Key Lab of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong, SAR. hrmaskf@hku.hk.
authors.forename: Kwok Fai
authors.initials: KF
authors.lastname: So
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D032305:Lycium / Q000737:chemistry*; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology
chemical_list: D018696:Neuroprotective Agents; D011134:Polysaccharides
keywords: LBP; Lycium barbarum; Mechanisms; Neuro-protective