title: Dengue tropism for macrophages and dendritic cells: the host cell effect.
abstract: Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC-derived virus. Taken together, our results highlight the importance of macrophages in dengue infection.
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Jacky
authors.initials: J
authors.lastname: Flipse
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.|Grupo Immunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
authors.forename: Silvia
authors.initials: S
authors.lastname: Torres
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.|Grupo Immunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
authors.forename: Mayra
authors.initials: M
authors.lastname: Diosa-Toro
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Heidi
authors.initials: H
authors.lastname: van der Ende-Metselaar
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: José
authors.initials: J
authors.lastname: Herrera-Rodriguez
authors.affiliation: Grupo Immunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
authors.forename: Silvio
authors.initials: S
authors.lastname: Urcuqui-Inchima
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Anke
authors.initials: A
authors.lastname: Huckriede
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Izabela A
authors.initials: IA
authors.lastname: Rodenhuis-Zybert
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Jolanda M
authors.initials: JM
authors.lastname: Smit
mesh_terms: D002478:Cells, Cultured; D003713:Dendritic Cells / Q000821:virology*; D003715:Dengue / Q000635:transmission* / Q000821:virology; D003716:Dengue Virus / Q000254:growth & development* / Q000472:pathogenicity*; D006801:Humans; D008264:Macrophages / Q000821:virology*; D014779:Virus Replication / Q000502:physiology*