title: Detection of Functional Homotopy in Traumatic Axonal Injury.
abstract: OBJECTIVE
  This study aimed to explore the interhemispheric intrinsic connectivity in traumatic axonal injury (TAI) patients.
  
  
  METHODS
  Twenty-one patients with TAI (14 males, seven females; mean age, 38.71 ± 15.25 years) and 22 well-matched healthy controls (16 males, six females; mean age, 38.50 ± 13.82 years) were recruited, and from them we obtained resting-state fMRI data. Interhemispheric coordination was examined using voxel-mirrored homotopic connectivity (VMHC) and seed-based functional connectivity analysis was performed.
  
  
  RESULTS
  We observed significantly decreased VMHC in a number of regions in TAI patients, including the prefrontal, temporal, occipital, parietal, and posterior cingulate cortices, thalami and cerebellar posterior lobes. Subsequent seed-based functional connectivity analysis revealed widely disrupted functional connectivity between the regions of local homotopic connectivity deficits and other areas of the brain, particularly the areas subserving the default, salience, integrative, and executive systems. The lower VMHC of the inferior frontal gyrus and basal ganglia, thalamus, and caudate were significant correlated with the Beck Depression Inventory score, Clinical Dementia Rating score, and Mini-Mental State Examination score, respectively.
  
  
  CONCLUSIONS
  TAI is associated with regionally decreased interhemispheric interactions and extensively disrupted seed-based functional connectivity, generating further evidence of diffuse disconnection being associated with clinical symptoms in TAI patients.
  
  
  CONCLUSIONS
  • Traumatic axonal injury is associated with decreased interhemispheric connectivity • Traumatic axonal injury couples with widely disrupted functional connectivity • These alterations support the default, salience, integrative, and executive functions.
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China. ncu6096@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Xie
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhan
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Fuqing
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Xianjun
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Laichang
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Nanchang University, 17 Yongwai Zheng Street, Donghu District, Nanchang City, Jiangxi, 330006, China.
authors.forename: Honghan
authors.initials: H
authors.lastname: Gong
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D020833:Diffuse Axonal Injury / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male
keywords: Brain; Homotopy; Interhemispheric connection; Resting-state fMRI; Traumatic axonal injury