title: Bioinformatics analysis of differentially expressed proteins in prostate cancer based on proteomics data.
abstract: We mined the literature for proteomics data to examine the occurrence and metastasis of prostate cancer (PCa) through a bioinformatics analysis. We divided the differentially expressed proteins (DEPs) into two groups: the group consisting of PCa and benign tissues (P&b) and the group presenting both high and low PCa metastatic tendencies (H&L). In the P&b group, we found 320 DEPs, 20 of which were reported more than three times, and DES was the most commonly reported. Among these DEPs, the expression levels of FGG, GSN, SERPINC1, TPM1, and TUBB4B have not yet been correlated with PCa. In the H&L group, we identified 353 DEPs, 13 of which were reported more than three times. Among these DEPs, MDH2 and MYH9 have not yet been correlated with PCa metastasis. We further confirmed that DES was differentially expressed between 30 cancer and 30 benign tissues. In addition, DEPs associated with protein transport, regulation of actin cytoskeleton, and the extracellular matrix (ECM)-receptor interaction pathway were prevalent in the H&L group and have not yet been studied in detail in this context. Proteins related to homeostasis, the wound-healing response, focal adhesions, and the complement and coagulation pathways were overrepresented in both groups. Our findings suggest that the repeatedly reported DEPs in the two groups may function as potential biomarkers for detecting PCa and predicting its aggressiveness. Furthermore, the implicated biological processes and signaling pathways may help elucidate the molecular mechanisms of PCa carcinogenesis and metastasis and provide new targets for clinical treatment.
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Li-Guo
authors.initials: LG
authors.lastname: Zhang
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Han
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: An-Liang
authors.initials: AL
authors.lastname: Yao
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Shao-San
authors.initials: SS
authors.lastname: Kang
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Gao
authors.affiliation: Department of Modern Technology and Education Center, North China University of Science and Technology, Tangshan, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Long-Jun
authors.initials: LJ
authors.lastname: Zhang
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Ya-Peng
authors.initials: YP
authors.lastname: Li
authors.affiliation: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
authors.forename: Feng-Hong
authors.initials: FH
authors.lastname: Cao
authors.affiliation: Department of Medical Research Center, International Science and Technology Cooperation Base of Geriatric Medicine, North China University of Science and Technology, Tangshan, People's Republic of China.
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Li
keywords: bioinformatics analysis; differentially expressed proteins; literature mining; metastasis; occurrence; prostate cancer; proteomics