title: Translation, Cross-Cultural Adaptation, and Validation of the Lee Chronic Graft-versus-Host Disease Symptom Scale in a Brazilian Population.
abstract: The Lee Chronic Graft-versus-Host Disease (GVHD) Symptom Scale is a patient-reported instrument developed and validated in English to measure the symptoms and functional impact of cGVHD. This tool has not yet been validated in a Latin American population, however. The Brazil-Seattle Chronic GVHD Consortium conducted a multicenter study at 5 Brazilian institutions to validate the Lee cGVHD Symptom Scale in adults with cGVHD. Study objectives included the translation and validation of the instrument in Brazilian Portuguese and evaluation of the correlation with other quality of life (QoL) tools, including the Medical Outcomes Study Short Form 36 (SF-36) and Functional Assessment of Chronic Illness Therapy with Bone Marrow Transplant subscale (FACT-BMT). Translation and validation were done according to the American Association of Orthopedic Surgeons Outcome Committee guidelines. Spearman's correlation coefficient was used to measure construct validity. Reliability was assessed using Cronbach's α and intraclass correlation coefficients. Between April 2011 and August 2012, 47 patients with cGVHD based on the 2005 National Institutes of Health criteria (29 males [62%], 18 females [38%]; median age, 48 years; range, 23 to 69 years) were enrolled in this study. The reliability of the Lee cGVHD Symptom Scale was adequate (Cronbach's α = 0.62 to 0.83). The correlations between similar domains of the Lee cGVHD Symptom Scale, SF-36, and FACT-BMT were moderate to high. Our data indicate that the Brazilian Portuguese version of the Lee cGVHD Symptom Scale is valid and reliable and can be used in clinical trials of cGVHD in Brazil.
authors.affiliation: Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil.
authors.forename: Clarissa
authors.initials: C
authors.lastname: Vasconcellos de Souza
authors.affiliation: Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil.
authors.forename: Afonso Celso
authors.initials: AC
authors.lastname: Vigorito
authors.affiliation: Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil.
authors.forename: Eliana C M
authors.initials: ECM
authors.lastname: Miranda
authors.affiliation: Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil.
authors.forename: Celso
authors.initials: C
authors.lastname: Garcia
authors.affiliation: Bone Marrow Transplant Unit, Hospital Amaral Carvalho, Jaú, Brazil.
authors.forename: Vergílio Antonio
authors.initials: VA
authors.lastname: Rensi Colturato
authors.affiliation: Bone Marrow Transplant Unit, Hospital Amaral Carvalho, Jaú, Brazil.
authors.forename: Marcos Augusto
authors.initials: MA
authors.lastname: Mauad
authors.affiliation: Bone Marrow Transplant Unit, National Institute of Cancer/Bone Marrow Transplant Center, Rio de Janeiro, Brazil.
authors.forename: Maria Cláudia
authors.initials: MC
authors.lastname: Rodrigues Moreira
authors.affiliation: Bone Marrow Transplant Unit, National Institute of Cancer/Bone Marrow Transplant Center, Rio de Janeiro, Brazil.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: da Silva Bouzas
authors.affiliation: Bone Marrow Transplant Unit, National Institute of Cancer/Bone Marrow Transplant Center, Rio de Janeiro, Brazil.
authors.forename: Simone
authors.initials: S
authors.lastname: Lermontov
authors.affiliation: Bone Marrow Transplant Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Nelson
authors.initials: N
authors.lastname: Hamerschlak
authors.affiliation: Bone Marrow Transplant Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Morgani
authors.initials: M
authors.lastname: Rodrigues
authors.affiliation: Bone Marrow Transplant Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.
authors.forename: Jose
authors.initials: J
authors.lastname: Carlos de Almeida Barros
authors.affiliation: Bone Marrow Transplant Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Chiattone
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Medical Oncology, University of Washington, Seattle, Washington.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Medical Oncology, University of Washington, Seattle, Washington. Electronic address: mflowers@fhcrc.org.
authors.forename: Mary E D
authors.initials: MED
authors.lastname: Flowers
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D002908:Chronic Disease; D003431:Cross-Cultural Comparison; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis*; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D055815:Young Adult
keywords: Allogeneic hematopoietic cell transplantation; Chronic graft-versus-host disease; Lee Chronic Graft-versus-Host Disease Symptom Scale; Patient-reported symptoms