title: Resveratrol and Ophthalmic Diseases.
abstract: Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically active component in red wine. Clinical studies have shown that resveratrol due to its potent anti-oxidant and anti-inflammatory properties are cardio-protective, chemotherapeutic, neuroprotective, and display anti-aging effects. Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular diseases (glaucoma, cataract, diabetic retinopathy and macular degeneration) that lead to progressive loss of vision and blindness. In vitro and in vivo (animal model) experimental studies performed so far have provided evidence for the biological effects of resveratrol on numerous pathways including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, pro-survival or angiogenesis that are implicated in the pathogenesis of these age-related ocular disorders. In this review, we provide a brief overview of current scientific literature on resveratrol, its plausible mechanism(s) of action, its potential use and current limitations as a nutritional therapeutic intervention in the eye and its related disorders.
authors.affiliation: Department of Ophthalmology, University of Florida College of Medicine, FL 32209, USA. abuamero@gmail.com.|Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11424, Saudi Arabia. abuamero@gmail.com.
authors.forename: Khaled K
authors.initials: KK
authors.lastname: Abu-Amero
authors.affiliation: Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11424, Saudi Arabia. akondkar@gmail.com.
authors.forename: Altaf A
authors.initials: AA
authors.lastname: Kondkar
authors.affiliation: Department of Ophthalmology, University of Florida College of Medicine, FL 32209, USA. Kakarla.Chalam@jax.ufl.edu.
authors.forename: Kakarla V
authors.initials: KV
authors.lastname: Chalam
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D005128:Eye Diseases / Q000517:prevention & control*; D005504:Food Analysis; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: age-related macular degeneration; cataract; diabetic retinopathy; eye; glaucoma; ocular disease; phytochemicals