title: Pulmonary Histoplasmosis in a Japanese Man Infected During Travel to Mexico and Management of His Wife's Condition: A Case Report.
abstract: We report herein on the case of a 33-year-old Japanese man in whom an abnormal shadow was detected on chest radiography during a medical checkup after a 1-year-stay in Mexico. Chest computed tomography showed a nodule in the left lower lobe adjacent to the visceral pleura. Histopathologic examination of a thoracoscopic partial pulmonary resection specimen showed coagulation necrosis with a number of yeast-like forms on Grocott staining. In addition, serum anti-Histoplasma antibody positivity was detected with an enzyme-linked immunosorbent assay, and Histoplasma-specific nested real-time polymerase chain reaction results were positive in the pulmonary region. Finally, pulmonary histoplasmosis was diagnosed, and treatment with itraconazole was initiated. The patient's wife who had accompanied him to Mexico was asymptomatic and was not found to have histoplasmosis based on diagnostic imaging and serological findings. Although rare in Japan, histoplasmosis should be considered in the differential diagnosis of pulmonary lesions in patients who have returned from travel to endemic areas.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Asahata-Tago
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ainoda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujita
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Muraosa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kamei
authors.forename: Megumi
authors.initials: M
authors.lastname: Wakayama
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
authors.forename: Ken
authors.initials: K
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007564:Japan; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008800:Mexico; D018454:Spouses; D014195:Travel; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole