title: The Evolution of "New Notes," Origins, and Future Directions.
abstract: The transformation of the submucosa into a working space provided a paradigm shift for endolumenal endoscopic intervention. The submucosal space can provide an undermining access to the removal of overlying mucosal disease. This space can also provide a protective mucosal barrier accommodating interventions into the deep layers of the gut wall and body cavities, such as the abdomen and mediastinum.
authors.affiliation: Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Saurabh S
authors.initials: SS
authors.lastname: Mukewar
authors.affiliation: Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: gostout.christopher@mayo.edu.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gostout
mesh_terms: D000069916:Endoscopic Mucosal Resection / Q000379:methods; D016099:Endoscopy, Gastrointestinal / Q000379:methods* / Q000639:trends; D005544:Forecasting; D006801:Humans; D007413:Intestinal Mucosa / Q000601:surgery; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods* / Q000639:trends
keywords: Endoscopic intervention; Hybrid endoscopic submucosal dissection; New NOTES; Submucosa; Submucosal endoscopy