title: Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration.
abstract: A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.
authors.affiliation: WPI Research Center Initiative, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan. NAKANISHI.Jun@nims.go.jp.
authors.forename: Masao
authors.initials: M
authors.lastname: Kamimura
authors.forename: Michiko
authors.initials: M
authors.lastname: Sugawara
authors.forename: Shota
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Jun
authors.initials: J
authors.lastname: Nakanishi
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001703:Biophysics / Q000379:methods*; D002448:Cell Adhesion; D002465:Cell Movement; D004285:Dogs / Q000293:injuries; D004847:Epithelial Cells / Q000378:metabolism / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry; D011107:Polylysine / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000180:Acrylic Resins; C016680:polyacrylamide gels; D011107:Polylysine; D011092:Polyethylene Glycols