title: Virulence-specific cell cycle and morphogenesis connections in pathogenic fungi.
abstract: To initiate pathogenic development, pathogenic fungi respond to a set of inductive cues. Some of them are of an extracellular nature (environmental signals), while others are intracellular (developmental signals). These signals must be integrated into a single response whose major outcome is changes in the morphogenesis of the fungus. The regulation of the cell cycle is pivotal during these cellular differentiation steps; therefore, cell cycle regulation would likely provide control points for infectious development by fungal pathogens. Here, we provide clues to understanding how the control of the cell cycle is integrated with the morphogenesis program in pathogenic fungi, and we review current examples that support these connections.
authors.affiliation: Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain. Electronic address: jose.perez@csic.es.
authors.forename: José
authors.initials: J
authors.lastname: Pérez-Martín
authors.affiliation: Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain.
authors.forename: Paola
authors.initials: P
authors.lastname: Bardetti
authors.affiliation: Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain.
authors.forename: Sónia
authors.initials: S
authors.lastname: Castanheira
authors.affiliation: Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: de la Torre
authors.affiliation: Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Tenorio-Gómez
mesh_terms: D002453:Cell Cycle; D005658:Fungi / Q000166:cytology* / Q000254:growth & development / Q000472:pathogenicity*; D008954:Models, Biological; D009024:Morphogenesis; D014774:Virulence
keywords: Appressorium; Candida albicans; Cell cycle; Fungal virulence; Magnaporthe oryzae; Ustilago maydis