title: Comparison of the isoflurane concentration of using dexketoprofen or methadone at premedication during orthopedic surgery in dogs.
abstract: Thirty-two dogs were used in this prospective, randomized, clinical and double-blinded study. Dexmedetomidine was administered at 1 μg/kg IV, and randomly each dog received dexketoprofen 1 mg/kg IV (group DK) or methadone 0.2 mg/kg IV (group M). Dogs were induced with propofol and maintained with isoflurane in 100% oxygen. During surgery, the isoflurane concentration was changed depending on clinical signs of depth of anesthesia. Fentanyl and propofol could be used as required. Qualities of sedation and recovery were evaluated. A generalized linear mixed model or Mann-Whiney U test was used, and P<0.05 was considered statistically significant. No significant differences were observed between groups in the qualities of sedation and recovery, isoflurane concentration and in the total amount of fentanyl and propofol used intraoperatively. This study shows that the administration of dexketoprofen at 1 mg/kg IV at premedication required a similar isoflurane concentration to maintain anesthesia as methadone at 0.2 mg/kg IV during orthopedic surgery in dogs. Further analgesia is recommended intraoperatively, because of the need of fentanyl and propofol in same animals in both groups.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain. Electronic address: v92nacar@uco.es.
authors.forename: Rocío
authors.initials: R
authors.lastname: Navarrete-Calvo
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: Álvaro J
authors.initials: ÁJ
authors.lastname: Gutiérrez-Bautista
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: María M
authors.initials: MM
authors.lastname: Granados
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Domínguez
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: J Andrés
authors.initials: JA
authors.lastname: Fernández-Sarmiento
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: Setefilla
authors.initials: S
authors.lastname: Quirós-Carmona
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Morgaz
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs / Q000601:surgery*; D004311:Double-Blind Method; D007530:Isoflurane / Q000008:administration & dosage / Q000627:therapeutic use; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008691:Methadone / Q000008:administration & dosage / Q000627:therapeutic use*; D009985:Orthopedics / Q000662:veterinary*; D011292:Premedication / Q000662:veterinary*; D011446:Prospective Studies; D014325:Tromethamine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D018685:Anesthetics, Inhalation; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; D007530:Isoflurane; C118296:dexketoprofen trometamol; D008691:Methadone
keywords: Anesthesia; Dexketoprofen; Dog; Isoflurane; Methadone