title: Invasive central nervous system aspergillosis in a patient with Crohn's disease after treatment with infliximab and corticosteroids.
abstract: Aspergillus species are emerging as a significant cause of pneumonia mortality in immune compromised hosts, with haematological spread being a rare and life-threatening complication. The central nervous system (CNS) as a site for extrapulmonary spread is rarer still. We report a case of CNS disseminated aspergillosis in a patient treated with corticosteroids and infliximab, an immunomodulatory agent commonly used in the treatment of inflammatory bowel disease, and review the available literature regarding this rare pathology.
authors.affiliation: John Hunter Hospital, Lookout Road, New Lambton Heights, NSW 2305, Australia. Electronic address: emmalee.bourne@hnehealth.nsw.gov.au.
authors.forename: Emma-Lee
authors.initials: EL
authors.lastname: Bourne
authors.affiliation: John Hunter Hospital, Lookout Road, New Lambton Heights, NSW 2305, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Dimou
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D000069285:Infliximab / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D000069285:Infliximab
keywords: Aspergillus; Central nervous system; Immunocompromised; Infliximab; Pneumonia