title: Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases.
abstract: Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, we summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vitreoretinopathy (PVR), diabeticretinopathy (DR), and ocular tumors. We intend to highlight comprehensive studies that provide detailed data about the mechanisms of lncRNAs, their applications as diagnostic or prognostic biomarkers, and their potential therapeutic targets. Although our understanding of lncRNAs is still in its infancy, these examples may provide helpful insights into the methods by which lncRNAs interfere with ocular diseases.
authors.affiliation: Department of Ophthalmology, Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China. lifangniuniu@126.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China. winston-a@hotmail.com.
authors.forename: Xuyang
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Ophthalmology, Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China. zhanghe@sjtu.edu.cn.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China. fanxq@sh163.net.
authors.forename: Xianqun
authors.initials: X
authors.lastname: Fan
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000235:genetics / Q000473:pathology; D005128:Eye Diseases / Q000235:genetics / Q000473:pathology*; D005901:Glaucoma / Q000235:genetics / Q000473:pathology; D006801:Humans; D062085:RNA, Long Noncoding / Q000378:metabolism*; D018630:Vitreoretinopathy, Proliferative / Q000235:genetics / Q000473:pathology
chemical_list: D015415:Biomarkers; D062085:RNA, Long Noncoding
keywords: epigenetics; long noncoding RNA; ocular disease