title: Multicenter randomized study on Me-CCNU, 5-FU and ADM vs ACNU, 5-FU and ADM for treatment of advanced gastric cancer.
abstract: OBJECTIVE
  To compare the efficacy of a combined chemotherapy regimen of 5-fluouracil (5-FU) and adriamycin (ADM) with nimustine hydrochloride (ACNU; brand name Nidran), a new nitrosourea agent, or with methyl-CCNU for advanced gastric cancer.
  
  
  METHODS
  One-hundred-and-three cases of advanced gastric cancer were randomly allocated into Group A (Me-CCNU, 5-FU and ADM combination) and Group B (ACNU, 5-FU and ADM combination). The quality of life (QOL) questionnaire, composed of 11 ordinal categorical items, was used to collect data from these patients.
  
  
  RESULTS
  Group A had no case of complete remission (CR) or partial remission (PR), while Group B had no CR but 8 PR (8/46 cases), for a response rate of 0% in Group A and 17.4% in Group B. The median survival time in Group A was 108 d and in Group B was 112 d. Both groups tolerated the treatment well and there were no serious adverse effects. QOL evaluations showed better psychological and physical feelings of tiredness for Group B than for Group A, and scores based on facial scaling showed a more pleasant inclination for the former.
  
  
  CONCLUSIONS
  ACNU combination is superior to the Me-CCNU combination for advanced gastric cancer patients.
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: S D
authors.initials: SD
authors.lastname: Xiao
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Li
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Zhang
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: M J
authors.initials: MJ
authors.lastname: Shen
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: X T
authors.initials: XT
authors.lastname: Zhu
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: G F
authors.initials: GF
authors.lastname: He
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: T P
authors.initials: TP
authors.lastname: Zhao
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Li
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Deng
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: C L
authors.initials: CL
authors.lastname: Yao
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: J G
authors.initials: JG
authors.lastname: Bao
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: G W
authors.initials: GW
authors.lastname: Tong
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: L F
authors.initials: LF
authors.lastname: Zhu
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Shu-Dong Xiao, De-Hua Li, De-Zhong Zhang, Mou-Ji Shen, Xiao-Ting Zhu, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China.
authors.forename: K
authors.initials: K
authors.lastname: Minoru
keywords: 5-fluouracil; Adriamycin; Mitomycin C; Nimustine hydrochloride; Stomach neoplasms