title: Surgical excision outcome after radial scar without atypical proliferative lesion on breast core needle biopsy: a single institutional analysis.
abstract: Radial scar (RS) has been recognized as a risk factor for developing breast cancer, and excision is recommended for patients with RS identified on core needle biopsy (CNB). However, recent literatures suggest that the increased risk may be caused by concurrent proliferative lesions on the biopsy, rather than radial scar itself. In this study, we investigated the follow-up excision (FUE) results for patients with RS on CNB with no history of a prior or a concurrent breast cancer or atypical proliferative lesions (APLs). A total of 113 RS cases including 32 cases with APLs or carcinoma and 81 cases without APLs on CNB were included in this study. Forty cases (49%) without APLs had FUE. No significant difference in radiologic and clinical findings was identified between cases with FUEs and cases without FUEs. Of the 40 cases with FUE, 9 cases (22.5%) were upgraded including 3 atypical ductal hyperplasias, 4 lobular neoplasias, 1 flat epithelial atypia, and 1 atypical apocrine adenosis. However, no case was upgraded to invasive carcinoma or ductal carcinoma in situ. All cases with mammotome CNBs were not upgraded. Our data suggest that conservative follow-up with imaging rather than surgical excisions may be more appropriate for patients with only RS on biopsy, especially for patients with mammotome CNBs.
authors.affiliation: Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH 43210.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Pathology, Ohio Valley Medical Center, Wheeling, WV 26003.
authors.forename: Shveta
authors.initials: S
authors.lastname: Hooda
authors.affiliation: Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH 43210. Electronic address: Zaibo.Li@osumc.edu.
authors.forename: Zaibo
authors.initials: Z
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D062005:Biopsy, Large-Core Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000601:surgery; D002921:Cicatrix / Q000473:pathology*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Atypical ductal hyperplasia; Breast cancer; Ductal carcinoma in-situ; Radial scar