title: Endogenous Generation of Singlet Oxygen and Ozone in Human and Animal Tissues: Mechanisms, Biological Significance, and Influence of Dietary Components.
abstract: Recent studies have shown that exposing antibodies or amino acids to singlet oxygen results in the formation of ozone (or an ozone-like oxidant) and hydrogen peroxide and that human neutrophils produce both singlet oxygen and ozone during bacterial killing. There is also mounting evidence that endogenous singlet oxygen production may be a common occurrence in cells through various mechanisms. Thus, the ozone-producing combination of singlet oxygen and amino acids might be a common cellular occurrence. This paper reviews the potential pathways of formation of singlet oxygen and ozone in vivo and also proposes some new pathways for singlet oxygen formation. Physiological consequences of the endogenous formation of these oxidants in human tissues are discussed, as well as examples of how dietary factors may promote or inhibit their generation and activity.
authors.affiliation: Department of Food Science and Technology, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi 00200, Kenya.
authors.forename: Arnold N
authors.identifier: 0000-0003-2078-6496
authors.initials: AN
authors.lastname: Onyango
mesh_terms: D000818:Animals; D004032:Diet; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000502:physiology / Q000528:radiation effects; D009504:Neutrophils / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010126:Ozone / Q000378:metabolism*; D011832:Radiation Injuries / Q000378:metabolism; D026082:Singlet Oxygen / Q000378:metabolism*
chemical_list: D016877:Oxidants; D026082:Singlet Oxygen; D010126:Ozone; D006861:Hydrogen Peroxide; D010100:Oxygen