title: High Yielding Microbubble Production Method.
abstract: Microfluidic approaches to microbubble production are generally disadvantaged by low yield and high susceptibility to (micro)channel blockages. This paper presents an alternative method of producing microbubbles of 2.6 μm mean diameter at concentrations in excess of 30 × 10(6) mL(-1). In this method, the nitrogen gas flowing inside the liquid jet is disintegrated into spray of microbubble when air surrounding this coflowing nitrogen gas-liquid jet passes through a 100 μm orifice at high velocity. Resulting microbubble foam has the polydispersity index of 16%. Moreover, a ratio of mean microbubble diameter to channel width ratio was found to be less than 0.025, which substantially alleviates the occurrence of blockages during production.
authors.affiliation: School of Engineering, The Robert Gordon University, Aberdeen AB10 7GE, UK.
authors.forename: Joe
authors.initials: J
authors.lastname: Fiabane
authors.affiliation: Institute for Medical Science and Technology, University of Dundee, Wilson House, 1 Wurzburg Loan, Dundee Medipark, Dundee DD2 1FD, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Prentice
authors.affiliation: School of Engineering, The Robert Gordon University, Aberdeen AB10 7GE, UK.
authors.forename: Ketan
authors.initials: K
authors.lastname: Pancholi
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D045423:Microbubbles; D044085:Microfluidics / Q000379:methods*; D009584:Nitrogen / Q000737:chemistry*; D010316:Particle Size
chemical_list: D003287:Contrast Media; D009584:Nitrogen