title: Atypical carcinoid and large cell neuroendocrine carcinoma of the lung: a proteomic dataset from formalin-fixed archival samples.
abstract: Here we present a dataset generated using formalin-fixed paraffin-embedded archival samples from two rare lung neuroendocrine tumor subtypes (namely, two atypical carcinoids, ACs, and two large-cell neuroendocrine carcinomas, LCNECs). Samples were subjected to a shotgun proteomics pipeline, comprising full-length protein extraction, SDS removal through spin columns, in solution trypsin digestion, long gradient liquid chromatography peptide separation and LTQ-Orbitrap mass spectrometry analysis. A total of 1260 and 2436 proteins were identified in the AC and LCNEC samples, respectively, with FDR <1%. MS data are available in the PeptideAtlas repository at http://www.peptideatlas.org/PASS/PASS00375.
authors.affiliation: Porto Conte Ricerche, Tramariglio, Alghero, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tanca
authors.affiliation: Porto Conte Ricerche, Tramariglio, Alghero, Italy.
authors.forename: Maria Filippa
authors.initials: MF
authors.lastname: Addis
authors.affiliation: Porto Conte Ricerche, Tramariglio, Alghero, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pisanu
authors.affiliation: Porto Conte Ricerche, Tramariglio, Alghero, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Abbondio
authors.affiliation: Porto Conte Ricerche, Tramariglio, Alghero, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Pagnozzi
authors.affiliation: U.O. di Anatomia Patologica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
authors.forename: Albino
authors.initials: A
authors.lastname: Eccher
authors.affiliation: Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore-Policlinico A. Gemelli, Rome, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Rindi
authors.affiliation: U.O. di Anatomia Patologica, Azienda Sanitaria Locale di Olbia, Olbia, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cossu-Rocca
authors.affiliation: Porto Conte Ricerche, Tramariglio, Alghero, Italy; Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Uzzau
authors.affiliation: NET Unit, Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, AOU Sassari, Sassari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Fanciulli
keywords: Archival tissues; FFPE; Mass spectrometry; Neuroendocrine tumors; Proteomics