title: MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease.
abstract: The discovery of the microRNA (miRNA) family of small RNAs as fundamental regulators of post-transcriptional gene expression has fostered research on their importance in every area of biology and clinical medicine. In the particular area of liver metabolism and disease, miRNAs are gaining increasing importance. By focusing on two fundamental hepatic biosynthetic pathways, glutathione and methionine, we review recent advances on the comprehension of the role of miRNAs in liver pathophysiology and more specifically of models of hepatic cholestasis/fibrosis and hepatocellular carcinoma.
authors.affiliation: Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Shelly C
authors.initials: SC
authors.lastname: Lu
authors.affiliation: CIC bioGUNE, (CIBERehd), Parque Tecnológico de Bizcaia, Derio, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Mato
authors.affiliation: Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
authors.forename: Cristina
authors.initials: C
authors.lastname: Espinosa-Diez
authors.affiliation: Department of Cell Biology and Immunology, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Nicolás Cabrera 1, 28049 Madrid, Spain. Electronic address: slamas@cbm.csic.es.
authors.forename: Santiago
authors.initials: S
authors.lastname: Lamas
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism* / Q000503:physiopathology; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008715:Methionine / Q000378:metabolism*; D035683:MicroRNAs
chemical_list: D035683:MicroRNAs; D008715:Methionine; D005978:Glutathione