title: Biocompatibility and safety of PLA and its copolymers.
abstract: PLA and its copolymers are commonly used for a wide variety of applications. While they are considered to be biocompatible, side effects resulting from their implantation have been reported. The implantation of biomaterials always results in a foreign body reaction. Such a reaction has also been reported following PLA and its copolymers. This article reviews the process of inflammatory reaction that is to be expected following implantation of PLA, and it highlights specific cases in which the inflammatory reaction can result in safety concerns. The authors also review selected cases from different medical fields to demonstrate possible clinical side effects resulting from its use.
authors.affiliation: Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Ramot
authors.affiliation: Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Haim-Zada
authors.affiliation: Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
authors.affiliation: Tel Aviv University, Tel Aviv, and Consultant in Toxicologic Pathology, Timrat, Israel. Electronic address: anyska@bezeqint.net.
authors.forename: Abraham
authors.initials: A
authors.lastname: Nyska
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry*; D005549:Foreign-Body Reaction / Q000139:chemically induced; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D011091:Polyesters / Q000009:adverse effects* / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)
keywords: Biocompatibility; Degradable materials; PLA; PLGL; Polymers; Toxicity