title: Retinal Pigment Epithelial Features in Central Serous Chorioretinopathy Identified by Polarization-Sensitive Optical Coherence Tomography.
abstract: OBJECTIVE
  To determine the subclinical RPE lesions detected by tissue selective polarization-sensitive optical coherence tomography (PS-OCT) in eyes with central serous chorioretinopathy (CSC) and to compare PS-OCT findings to current imaging standards.
  
  
  METHODS
  In this prospective observational case series, individuals with unilateral or bilateral active CSC were imaged using PS-OCT at baseline and after resolution of serous retinal detachment. Features seen on PS-OCT were compared with corresponding lesions as seen on conventional, intensity-based spectral-domain OCT (SD-OCT), fluorescein angiography, and indocyanine green angiography (ICGA). Features of RPE evaluated by PS-OCT were as follows: area and volume of pigment epithelium detachment (PED), presence of RPE aggregations, RPE skip lesions, RPE thickening, and RPE atrophy.
  
  
  RESULTS
  Twenty-five study eyes and 23 fellow eyes of 25 participants (2 women, 23 men; mean age ± standard deviation = 40.5 ± 7.4 years) were included and followed for 6.1 ± 3 months. Study eyes and fellow eyes with recurrent CSC showed more RPE abnormalities in PS-OCT than eyes with acute CSC, which correlated well with lesions in ICGA. Closure of the leakage site was observed only in eight (32%) eyes after resolution of subretinal fluid (SRF). All study eyes showed widespread RPE aggregates and 23 (92%) eyes showed RPE skip lesions after resolution of SRF.
  
  
  CONCLUSIONS
  Features of RPE indicative of previous episodes of CSC detected by PS-OCT correspond well to choroidal lesions in ICGA. In addition, noninvasive PS-OCT imaging enables detection of RPE microrips and aggregations invisible to clinical examination or SD-OCT, thus providing valuable information about disease processes in vivo.
authors.affiliation: Department of Ophthalmology and Optometry of the Medical University of Vienna Vienna, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Roberts
authors.affiliation: Center for Medical Physics and Biomedical Engineering of the Medical University of Vienna, Vienna, Austria.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Baumann
authors.affiliation: Department of Ophthalmology and Optometry of the Medical University of Vienna Vienna, Austria.
authors.forename: Jan
authors.initials: J
authors.lastname: Lammer
authors.affiliation: Department of Ophthalmology and Optometry of the Medical University of Vienna Vienna, Austria.
authors.forename: Bianca
authors.initials: B
authors.lastname: Gerendas
authors.affiliation: Department of Ophthalmology and Optometry of the Medical University of Vienna Vienna, Austria.
authors.forename: Julia
authors.initials: J
authors.lastname: Kroisamer
authors.affiliation: Department of Ophthalmology and Optometry of the Medical University of Vienna Vienna, Austria.
authors.forename: Wolf
authors.initials: W
authors.lastname: Bühl
authors.affiliation: Center for Medical Physics and Biomedical Engineering of the Medical University of Vienna, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Pircher
authors.affiliation: Center for Medical Physics and Biomedical Engineering of the Medical University of Vienna, Vienna, Austria.
authors.forename: Christoph K
authors.initials: CK
authors.lastname: Hitzenberger
authors.affiliation: Department of Ophthalmology and Optometry of the Medical University of Vienna Vienna, Austria.
authors.forename: Ursula
authors.initials: U
authors.lastname: Schmidt-Erfurth
authors.affiliation: Department of Ophthalmology and Optometry of the Medical University of Vienna Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis*; D004396:Coloring Agents / Q000008:administration & dosage; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green