title: In Situ Visualization of the Local Photothermal Effect Produced on α-Cyclodextrin Inclusion Compound Associated with Gold Nanoparticles.
abstract: Evidence of guest migration in α-cyclodextrin-octylamine (α-CD-OA) inclusion compound (IC) generated via plasmonic heating of gold nanoparticles (AuNPs) has been studied. In this report, we demonstrate local effects generated by laser-mediated irradiation of a sample of AuNPs covered with inclusion compounds on surface-derivatized glass under liquid conditions by atomic force microscopy (AFM). Functionalized AuNPs on the glass and covered by the ICs were monitored by recording images by AFM during 5 h of irradiation, and images showed that after irradiation, a drastic decrease in the height of the AuNPs occurred. The absorption spectrum of the irradiated sample showed a hypsochromic shift from 542 to 536 nm, evidence suggesting that much of the population of nanoparticles lost all of the parts of the overlay of ICs due to the plasmonic heat generated by the irradiation. Mass spectrometry matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) performed on a sample containing a collection of drops obtained from the surface of the functionalized glass provided evidence that the irradiation lead to disintegration of the ICs and therefore exit of the octylamine molecule (the guest) from the cyclodextrin cavity (the matrix). Graphical Abstract Atomic Force Microscopy observation of the disintegration of a cyclodextrin inclusion compound by gold nanoparticles photothermal effect.
authors.affiliation: Department of Chemistry, Universidad de Chile, Las Palmeras, 3425, Santiago, Chile.
authors.forename: Nataly
authors.initials: N
authors.lastname: Silva
authors.affiliation: Department of Chemistry, Universidad de Chile, Las Palmeras, 3425, Santiago, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: Muñoz
authors.affiliation: Centros científicos y tecnológicos (CCiTUB) y NanoDivulga, Universidad de Barcelona, Lluís Solé i Sabaris 1-3, Barcelona, 08028, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Diaz-Marcos
authors.affiliation: Nanobioengineering Laboratory, Institute for Bioengineering of Catalonia (IBEC), BaldiriReixac,10-12, Barcelona, 08028, Spain.|Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Maria de Luna, 11, 50018, Zaragoza, Spain.|Department of Electronics, Barcelona University (UB), Martí I Franques, 1, Barcelona, 08028, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Samitier
authors.affiliation: Department of Chemistry, Universidad de Chile, Las Palmeras, 3425, Santiago, Chile.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Yutronic
authors.affiliation: Department of Pharmacological and Toxicological Chemistry, Universidad de Chile, Sergio Livingston 1007, Santiago, Chile. mkogan@ciq.uchile.cl.|Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile. mkogan@ciq.uchile.cl.
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Kogan
authors.affiliation: Department of Chemistry, Universidad de Chile, Las Palmeras, 3425, Santiago, Chile. pjara@uchile.cl.
authors.forename: Paul
authors.initials: P
authors.lastname: Jara
keywords: Cyclodextrin inclusion compound; Gold nanoparticles; Guest migration; Plasmonic heating