title: The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis.
abstract: Despite the fact that Candida albicans is an important human fungal pathogen and Dectin-2 is a major pattern recognition receptor for fungi, our knowledge regarding the role of Dectin-2 for the host defense against disseminated candidiasis is limited. Dectin-2 deficient (Dectin-2(-/-)) mice were more susceptible to systemic candidiasis, and the susceptibility was mirrored by an elevated fungal load in the kidneys that correlated with the presence of large inflammatory foci. Phagocytosis of Candida by the macrophages lacking the Dectin-2 receptor was moderately decreased, while production of most of the macrophage-derived cytokines from Dectin-2(-/-) mice with systemic candidiasis was decreased. No striking differences among several Candida mutants defective in mannans could be detected between naïve wild-type and Dectin-2(-/-) mice, apart from the β-mannan-deficient bmt1Δ/bmt2Δ/bmt5Δ triple mutant, suggesting that β-mannan may partially mask α-mannan detection, which is the major fungal structure recognized by Dectin-2. Deciphering the mechanisms responsible for host defense against the majority of C. albicans strains represents an important step in understanding the pathophysiology of systemic candidiasis, which might lead to the development of novel immunotherapeutic strategies.
authors.affiliation: 1 Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Ifrim
authors.affiliation: 1 Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: Jessica
authors.initials: J
authors.lastname: Quintin
authors.affiliation: 2 Inserm U995 , Lille, France .|3 Université de Lille , Faculté de Médecine, Lille, France .
authors.forename: Flavie
authors.initials: F
authors.lastname: Courjol
authors.affiliation: 1 Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: Ineke
authors.initials: I
authors.lastname: Verschueren
authors.affiliation: 4 Department of Pathology, Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: J Han
authors.initials: JH
authors.lastname: van Krieken
authors.affiliation: 5 Ozgene Pty Ltd , Bentley DC, Australia .
authors.forename: Frank
authors.initials: F
authors.lastname: Koentgen
authors.affiliation: 2 Inserm U995 , Lille, France .|3 Université de Lille , Faculté de Médecine, Lille, France .
authors.forename: Chantal
authors.initials: C
authors.lastname: Fradin
authors.affiliation: 6 Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen , Aberdeen, United Kingdom .
authors.forename: Neil A R
authors.initials: NA
authors.lastname: Gow
authors.affiliation: 1 Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: Leo A B
authors.initials: LA
authors.lastname: Joosten
authors.affiliation: 1 Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: Jos W M
authors.initials: JW
authors.lastname: van der Meer
authors.affiliation: 1 Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: Frank
authors.initials: F
authors.lastname: van de Veerdonk
authors.affiliation: 1 Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre , Nijmegen, The Netherlands .
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000502:physiology*; D002177:Candidiasis / Q000276:immunology* / Q000382:microbiology; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007668:Kidney / Q000276:immunology* / Q000382:microbiology; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism*; D008264:Macrophages / Q000382:microbiology / Q000502:physiology*; D008351:Mannans / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009154:Mutation / Q000235:genetics; D010587:Phagocytosis / Q000235:genetics
chemical_list: D037181:Lectins, C-Type; D008351:Mannans; C445340:dectin-2, mouse