title: [ACTUAL PROBLEMS OF EPIDEMIOLOGIC CONTROL, LABORATORY DIAGNOSTICS AND PROPHYLAXIS OF CHOLERA IN RUSSIAN FEDERATION].
abstract: Main problems of system of epidemiologic control for cholera active in Russian Federation, as well as laboratory diagnostics and vaccine prophylaxis of this especially dangerous infection, that had emerged in the contemporary period of the ongoing 7th pandemic of cholera, are discussed. Features of the genome of natural strains of Vibrio cholerae of El Tor biovar, that possess a poten- tial epidemic threat, as well as problems, that have emerged during isolation of these strains from samples of water of surface water bodies during their monitoring, are also examined. The main direction of enhancement of the system of epidemiologic control for cholera consist in develop- ment of a new algorithm of differentiation of administrative territories of Russian Federation by types of epidemic manifestations, as well as optimization of monitoring of environment objects. Integration of modern highly informative technologies into practice, as well as development of new generation diagnostic preparations based on DNA-chips and immunechips is necessary to increase effectiveness of the conducted operative and retrospective diagnostics in the contemporary period. Creation of national cholera vaccine, ensuring simultaneous protection from cholera causative agents of both O1 and O139 serogroups, is also required.
authors.forename: G G
authors.initials: GG
authors.lastname: Onischenko
authors.forename: A Yu
authors.initials: AY
authors.lastname: Popova
authors.forename: V V
authors.initials: VV
authors.lastname: Kutyrev
authors.forename: N I
authors.initials: NI
authors.lastname: Smirnova
authors.forename: S A
authors.initials: SA
authors.lastname: Scherbakova
authors.forename: E A
authors.initials: EA
authors.lastname: Moskvitina
authors.forename: S V
authors.initials: SV
authors.lastname: Titova
mesh_terms: D015373:Bacterial Typing Techniques; D002771:Cholera / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D004196:Disease Outbreaks; D062665:Epidemiological Monitoring; D005838:Genotype; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010802:Phylogeny; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D065288:Serogroup; D014734:Vibrio cholerae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D014871:Water Microbiology