title: Hypoxia-Inducible Factor-1α and Autoimmune Lupus, Arthritis.
abstract: Hypoxia elicits an orchestrated response in cells, tissues, and entire organisms to survive a hypoxic challenge. On a molecular level, this response can be controlled by oxygen-dependent stabilization of the transcription factor hypoxia-inducible factor (HIF)-1α. Recently, studies have shown that HIF-1α plays an important role in the development and function of T helper (Th) cells, regulatory T (Treg) cells, and dendritic cells (DCs). Because these cells are critical in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, the roles of HIF-1α in these autoimmune disorders cannot be neglected. In this review, we discuss recent findings on the important roles of HIF-1α in immune cells and the possible pathologic roles of HIF-1α in autoimmune diseases. The obtained information may lead to deeper insights into the roles of HIF-1α in these disorders.
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan, 610041, People's Republic of China.
authors.forename: Zu-Cheng
authors.initials: ZC
authors.lastname: Yang
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan, 610041, People's Republic of China. yi2006liu@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood / Q000209:etiology; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology*; D007107:Immune System / Q000166:cytology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000209:etiology
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: HIF-1α; lupus; rheumatoid arthritis