title: Steering through complexity: management approaches in multiple sclerosis.
abstract: This review evaluates current and late-phase developing therapies for multiple sclerosis in regard to therapeutic efficacy and patient safety in light of recent published and presented observations from 2015.
  
  
  
  We describe data that provide supportive evidence for comparisons of therapeutic efficacy of multiple sclerosis therapies and review available data on rare but serious adverse events associated with these therapies.
  
  
  
  Serious adverse events that are sometimes rare and unpredictable may substantially alter current approaches to multiple sclerosis treatments. New therapies that have proved superior effects compared with older therapies will also impact multiple sclerosis treatment practice in the near future.
authors.affiliation: aDepartment of Neurology, Multiple Sclerosis Center, University of California, San Francisco, California, USA bDepartment of Neurology and Center for Neuropsychiatry, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Bruce A C
authors.initials: BA
authors.lastname: Cree
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D019090:Case Management; D018450:Disease Progression; D006801:Humans; D007166:Immunosuppressive Agents; D009103:Multiple Sclerosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents