title: A two-pronged attack on DNA: targeting guanine quadruplexes with nonplanar porphyrins and DNA-binding small molecules.
authors.affiliation: School of Chemistry, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland.
authors.forename: Isabel
authors.initials: I
authors.lastname: Rozas
authors.affiliation: Medicinal Chemistry, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, the University of Dublin, St James's Hospital, Dublin 8, Ireland.
authors.forename: Mathias O
authors.initials: MO
authors.lastname: Senge
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects*; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004273:DNA, Neoplasm; D011166:Porphyrins; D054852:Small Molecule Libraries
keywords: DNA targeting; drug development; guanine quadruplexes; oncogene promoters; photomedicine; photosensitizers; porphyrins