title: [Augmented renal clearance of antibiotics may lead to inadequate dosings for patients with sepsis].
abstract: Early, relevant antibiotic treatment is of pivotal significance for survival for patients with sepsis. Recent reports reveal, that critically ill patients may need substantially higher dosing of antibiotics than the usual standards. The background is the newly described augmented renal clearance (ARC), which can be observed in critically ill patients with sepsis. ARC results in significantly reduced antibiotic concentrations in patients with sepsis and can potentially have fatal consequences. The purpose of this paper is to make medical doctors aware of the phenomenon and to compensate for the increased antibiotic clearance.
authors.affiliation: moser@dadlnet.dk.
authors.forename: Claus
authors.initials: C
authors.lastname: Moser
authors.forename: Tom
authors.initials: T
authors.lastname: Hartvig
authors.forename: Jens
authors.initials: J
authors.lastname: Schierbeck
authors.forename: Niels
authors.initials: N
authors.lastname: Høiby
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D016638:Critical Illness; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008657:Metabolic Clearance Rate; D011247:Pregnancy; D018805:Sepsis / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents