title: Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters.
abstract: In an effort to mimic in part the redundancy of satiety peptides involved in energy homeostasis, the combined benefits of the well-established satiety peptide CCK8 and an apparently anorectic peptide obestatin were studied in Swiss albino mice. The optimal dose of obestatin that was required to give the most pronounced effect with CCK8 was worked out by varying the concentration of obestatin while keeping CCK8 concentration constant at 200 nmol/KgBW. Mice administered 160 nmol obestatin and 200 nmol CCK8 per kilogram body weight showed the most drastic reduction in food intake. Gain in body weight was arrested after day four during the eight day experiment. These studies reemphasize the beneficial effects imparted by co-administration of obestatin and CCK8 and their potential use towards countering obesity.
authors.affiliation: Department of Lipid Science, CSIR-Central Food Technological Research Institute, Mysore, 570 020, India.
authors.forename: ShreeRanga
authors.initials: S
authors.lastname: Nagaraj
authors.affiliation: Department of Lipid Science, CSIR-Central Food Technological Research Institute, Mysore, 570 020, India. Electronic address: umamanjappara@cftri.res.in.
authors.forename: Uma V
authors.initials: UV
authors.lastname: Manjappara
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051379:Mice; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D036361:Peptide Hormones / Q000494:pharmacology*; D012844:Sincalide / Q000494:pharmacology*
chemical_list: D036361:Peptide Hormones; C512328:obestatin, mouse; D012844:Sincalide
keywords: CCK8; Epididymal fat; Obestatin; Satiety