title: Six New Lanostane Triterpenoids from the Fruiting Body of Tyromyces sambuceus and Antiproliferative Activity.
abstract: During the search for secondary metabolites with antiproliferative activity, six new lanostane triterpenoids, tyrosamic acids A-F (1-6) together with ten known compounds (7-16), were isolated from the fruiting body of Tyromyces sambuceus. Their structures were elucidated using MS analyses, extensive 2D-heteronuclear NMR data interpretation and the structure of 3 was further confirmed by single-crystal X-ray data analyses. All lanostane triterpenoids (1-16) possesses a carboxy group at C-20 position and their strength of antiproliferative activity was affected by the presence or absence of a hydroxy group at C-15 position and at the side chain. Four of the compounds (1, 6, 10, 14) showed antiproliferative activities against human cancer cell lines with IC₅₀ values of 16.8-48.3 µM (HL-60).
authors.forename: Naoki
authors.initials: N
authors.lastname: Kokudo
authors.forename: Mina
authors.initials: M
authors.lastname: Okazoe
authors.forename: Joji
authors.initials: J
authors.lastname: Takahashi
authors.forename: Kanako
authors.initials: K
authors.lastname: Iseki
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Hirosi
authors.initials: H
authors.lastname: Imagawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Noji
authors.forename: Akemi
authors.initials: A
authors.lastname: Umeyama
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D011124:Polyporaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000145:classification
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes