title: Electrospun nanofibers for cancer diagnosis and therapy.
abstract: The advent of nanotechnology has provided unprecedented opportunities for nanomedicine. Electrospun nanofibers have some astounding features such as high loading capacity, extremely large surface area and porosity, high encapsulation efficiency, ease of modification, combination of diverse therapies, low cost and great benefits. These remarkable structure-dependent properties have far reaching application potential in cancer diagnosis and therapy such as ultra-sensitive sensing systems for point-of-care cancer detection, targeted cancer cell capture, and functional and smart anticancer drug delivery systems. This review summarizes the principal mechanism of electrospun nanofibers and a variety of modified electrospun nanofibers, illustrates their application in biosensors for cancer detection, and enumerates their application in implantable drug delivery for cancer therapy.
authors.affiliation: College of Material Science and technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R. China. zhaofeng_chen@163.com.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Chen
authors.forename: Zhaofeng
authors.initials: Z
authors.lastname: Chen
authors.forename: Aili
authors.initials: A
authors.lastname: Zhang
authors.forename: Jiaming
authors.initials: J
authors.lastname: Hu
authors.forename: Xinmei
authors.initials: X
authors.lastname: Wang
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D051379:Mice; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use*; D050997:Nanomedicine; D036103:Nanotechnology; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents