title: Lineage specification in the mouse preimplantation embryo.
abstract: During mouse preimplantation embryo development, totipotent blastomeres generate the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In recent years, studies have shown that this process appears to be regulated by differences in cell-cell interactions, gene expression and the microenvironment of individual cells, rather than the active partitioning of maternal determinants. Precisely how these differences first emerge and how they dictate subsequent molecular and cellular behaviours are key questions in the field. As we review here, recent advances in live imaging, computational modelling and single-cell transcriptome analyses are providing new insights into these questions.
authors.affiliation: Université Clermont Auvergne, Laboratoire GReD, Clermont-Ferrand F-63000, France Inserm, UMR1103, Clermont-Ferrand F-63001, France CNRS, UMR6293, Clermont-Ferrand F-63001, France claire.chazaud@udamail.fr yojiro.yamanaka@mcgill.ca.
authors.forename: Claire
authors.initials: C
authors.lastname: Chazaud
authors.affiliation: Goodman Cancer Research Centre, Department of Human Genetics, McGill University, 1160 Pine Avenue West, rm419, Montreal, Quebec, Canada H3A 1A3 claire.chazaud@udamail.fr yojiro.yamanaka@mcgill.ca.
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Yamanaka
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000166:cytology* / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D004622:Embryo, Mammalian / Q000196:embryology*; D047108:Embryonic Development / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D023421:Models, Animal; D009024:Morphogenesis / Q000502:physiology*
keywords: Cell heterogeneity; Lineage differentiation; Morphogenesis; Mouse; Preimplantation