title: Resolution of Internal Carotid Arterial Thrombus by the Thrombolytic Action of Dabigatran: A first case report.
abstract: Non-vitamin K antagonist oral anticoagulants (NOACs) have been reported to cause resolution of intracardiac thrombus, but there have been no reported cases of internal carotid arterial thrombus resolution.We report a case of a 76-year-old man in whom an internal carotid arterial thrombus resolved after administration of the NOAC dabigatran at a dose of 110  mg twice daily.This is the first reported case of carotid arterial thrombus resolution after oral intake of NOAC (direct thrombin and factor Xa inhibitors), to the best of our knowledge.We conclude that this case had major clinical significance because it might represent one of the multiple effects of NOACs.
authors.affiliation: From the Department of Neurology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan (HA, MH, TS, YH).
authors.forename: Hisanao
authors.initials: H
authors.lastname: Akiyama
authors.forename: Masashi
authors.initials: M
authors.lastname: Hoshino
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shimizu
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hasegawa
mesh_terms: D000368:Aged; D000991:Antithrombins / Q000627:therapeutic use*; D002341:Carotid Artery Thrombosis / Q000188:drug therapy*; D000069604:Dabigatran / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012074:Remission Induction; D015912:Thrombolytic Therapy
chemical_list: D000991:Antithrombins; D000069604:Dabigatran