title: Anemia in patients undergoing ambulatory peritoneal dialysis: prevalence and associated factors.
abstract: BACKGROUND
  Anemia is a common complication in dialysis patients, scare studies have evaluated anemia in patients undergoing peritoneal dialysis (PD).
  
  
  OBJECTIVE
  This study aimed to investigate the prevalence of anemia and its associated factors in patients undergoing PD in a single center where patients have free access to agents stimulating erythropoiesis (ESA) and intravenous iron supplementation.
  
  
  METHODS
  Cross-sectional study analyzing the demographic, clinical and laboratory variables of 120 patients. Anemia was defined as hemoglobin (Hb) < 11 g/dl.
  
  
  RESULTS
  Patients were on PD for 17 months, and the majority of them (86%) received automated PD. The mean age was 58 ± 16.5 years, and 52% were female and 29% were diabetes. Anemia was present in 34 (28%) patients. When compared with those without anemia, patients with anemia received a higher dose of iron (p = 0.02) and had a lower concentration of triglycerides (p = 0.01). Hb levels correlated negatively with iron (r = -0.20;p = 0.03) and ESA (r = -0.23; p = 0.01) doses and positively with albumin (r = 0.38; p = 0.01), triglycerides (r = 0.24; p = 0.01) and transferrin saturation (r = 0.20; p = 0.03). In multiple analyses, only the albumin concentration (beta = 0.84; 95% IC = 0.38-1.31;p < 0.001) and ESA dose (beta = -0.06; 95% IC = 0.00-0.00; p = 0.02) were independently associated with Hb levels.
  
  
  CONCLUSIONS
  Almost 30% of PD patients had anemia, even with free access to erythropoietin and intravenous iron. The transferrin saturation and nutritional status assessed by albumin, were the factors associated with the occurrence of anemia in this population.
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Marisa Cristiane Cardoso de
authors.initials: MC
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Adriano Luis
authors.initials: AL
authors.lastname: Ammirati
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Maria Claudia
authors.initials: MC
authors.lastname: Andreolli
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Marco Antonio Justo
authors.initials: MA
authors.lastname: Nadalleto
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Camila Barbosa Silva
authors.initials: CB
authors.lastname: Barros
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Maria Eugênia Fernandes
authors.initials: ME
authors.lastname: Canziani
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004921:Erythropoietin / Q000627:therapeutic use; D005260:Female; D006397:Hematinics / Q000627:therapeutic use; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D015995:Prevalence
chemical_list: D006397:Hematinics; D006454:Hemoglobins; D004921:Erythropoietin