title: Rhabdomyolysis following Cardiac Surgery: A Prospective, Descriptive, Single-Center Study.
abstract: OBJECTIVE
  Rhabdomyolysis (RML) following cardiac surgery and its relationship with acute kidney injury (AKI) require investigation.
  
  
  METHODS
  All patients undergoing cardiac surgery in our hospital were enrolled in this prospective study during a 1-year period. To investigate the occurrence of RML and its association with AKI, all patients in the study underwent serial assessment of serum creatine kinase (CK) and myoglobin levels. Serial renal function, prior statin treatment, and outcome variables were recorded.
  
  
  RESULTS
  In total, 201 patients were included in the study: 185 men and 16 women with a mean age of 52.0 ± 12.4 years. According to the presence of RML (CK of ≥2,500 U/L), the patients were divided into Group I (RML present in 17 patients) and Group II (RML absent in 184 patients). Seven patients in Group I had AKI (41%) where 34 patients in group II had AKI (18.4%), P = 0.025. We observed a significantly longer duration of ventilation, length of stay in the ICU, and hospitalization in Group I (P < 0.001 for all observations).
  
  
  CONCLUSIONS
  An early elevation of serum CK above 2500 U/L postoperatively in high-risk cardiac surgery could be used to diagnose RML that may predict the concomitance of early AKI.
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar; Department of Critical Care Medicine, Beni-Suef University, P.O. Box 62511, Beni-Suef, Egypt.
authors.forename: Amr S
authors.identifier: 0000-0001-8560-2745
authors.initials: AS
authors.lastname: Omar
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar; Department of Anesthesia, Suez Canal University, P.O. Box 351-41511, Ismailia, Egypt.
authors.forename: Hesham
authors.initials: H
authors.lastname: Ewila
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar; Department of Anesthesia, Ain Shams University, Kasr-El-Zaafaran, P.O. Box 11566, Cairo, Egypt.
authors.forename: Sameh
authors.initials: S
authors.lastname: Aboulnaga
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Alejandro Kohn
authors.initials: AK
authors.lastname: Tuli
authors.affiliation: Department of Cardiology Research Centre, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Rajvir
authors.initials: R
authors.lastname: Singh
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology* / Q000473:pathology; D000328:Adult; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood; D012206:Rhabdomyolysis / Q000097:blood* / Q000150:complications / Q000473:pathology
chemical_list: D009211:Myoglobin; D003402:Creatine Kinase