title: A Novel and Efficient Five-Component Synthesis of Pyrazole Based Pyrido[2,3-d]pyrimidine-diones in Water: A Triply Green Synthesis.
abstract: A novel one pot synthesis of pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine-diones, via a five-component reaction, involving, hydrazine hydrate, ethyl acetoacetate, and 1,3-dimethyl barbituric acid, an appropriate aryl aldehydes and ammonium acetate catalyzed via both of heterogeneous and homogeneous catalysis in water, is reported.
authors.affiliation: Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993893973, Iran. mmh1331@yahoo.com.
authors.forename: Majid M
authors.initials: MM
authors.lastname: Heravi
authors.affiliation: Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993893973, Iran. daraie_m@yahoo.com.
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Daraie
mesh_terms: D000085:Acetates / Q000737:chemistry; D000090:Acetoacetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D001463:Barbiturates / Q000737:chemistry; D002384:Catalysis; D006834:Hydrazines / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000085:Acetates; D000090:Acetoacetates; D000447:Aldehydes; D001463:Barbiturates; D006834:Hydrazines; D011720:Pyrazoles; D011743:Pyrimidines; D014867:Water; C029424:hydrazine; C031280:pyrazole; C024840:ethyl acetoacetate; C018824:ammonium acetate; C032232:barbituric acid
keywords: green synthesis; in water reaction; multi-component reaction; pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-diones