title: Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
abstract: OBJECTIVE
  Altered paraoxonase (PON) and arylesterase (ARE) activities have been shown in anemic chronic kidney disease (CKD) patients and in iron deficiency anemia (IDA) patients. Whether accompanying anemia alone is responsible for this diminished PON and ARE activities in CKD patients or an additive factor for this is not well studied. Therefore, we tried to clarify this issue here.
  
  
  METHODS
  A total of 82 subjects that consisted of 19 patients with IDA (group 1), 23 anemic CKD patients (group 2), and 40 age and sex matched healthy subjects (group 3) were enrolled. Carotid intima media thickness (CIMT), serum total thiol (-SH), PON, and ARE activities of the participants were analyzed.
  
  
  RESULTS
  Group 2 patients had significantly lowest serum levels of Total -SH, PON and ARE. Further comparison showed that total -SH, PON and ARE levels were lower in group 1 than group 3 (p = 0.0001 in both). Regarding comparison of group 1 and 2, only serum ARE levels were significantly lower in group 2 (p = 0.001). PON activity was not different between group 1 and group 2 whereas ARE activity was lower in group 2 than groups 1 and 3. In addition, correlation analysis showed that CIMT was negatively correlated with PON and ARE.
  
  
  CONCLUSIONS
  This markedly decreased ARE activity in CKD patients, which could not be explained by the anemia alone, may have a role in the pathogenesis of increased atherosclerosis in such patients. Still further studies are needed to certain this.
authors.affiliation: a Department of Internal Medicine , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Okuturlar
authors.affiliation: b Department of Nephrology , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Nilgul
authors.initials: N
authors.lastname: Akalin
authors.affiliation: b Department of Nephrology , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Ozlem Harmankaya
authors.initials: OH
authors.lastname: Kaptanogullari
authors.affiliation: c Department of Radiology , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Nurten Turan
authors.initials: NT
authors.lastname: Guner
authors.affiliation: a Department of Internal Medicine , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Deniz
authors.initials: D
authors.lastname: Yilmaz
authors.affiliation: d Department of Biochemistry , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Asuman
authors.initials: A
authors.lastname: Gedikbasi
authors.affiliation: e Department of Endocrinology and Metabolism , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Ozlem
authors.initials: O
authors.lastname: Soyluk
authors.affiliation: e Department of Endocrinology and Metabolism , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Meral
authors.initials: M
authors.lastname: Mert
authors.affiliation: f Department of Internal Medicine , Umraniye Education and Research Hospital , Istanbul , Turkey.
authors.forename: Sibel Ocak
authors.initials: SO
authors.lastname: Serin
authors.affiliation: a Department of Internal Medicine , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Hakan
authors.initials: H
authors.lastname: Kocoglu
authors.affiliation: a Department of Internal Medicine , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Mehmet
authors.initials: M
authors.lastname: Hursitoglu
authors.affiliation: a Department of Internal Medicine , Bakirkoy Dr. Sadi Konuk Education and Research Hospital , Istanbul , Turkey ;
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Kumbasar
mesh_terms: D000328:Adult; D000747:Anemia, Hypochromic / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D015203:Reproducibility of Results; D013223:Statistics as Topic
chemical_list: D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase
keywords: Anemia; arylesterase; atherosclerosis; chronic kidney disease; paraoxonase