title: STAT5 Loss Awakens the Dark Force in Natural Killer Cells.
abstract: Natural killer cells (NK) are commonly considered to be potent antitumor effector cells. The study by Gotthardt and colleagues challenges this concept and reveals that STAT5-deficient/inhibited NK cells induce angiogenesis and promote tumor progression. These unexpected findings shed new light on potential adverse effects of JAK-STAT inhibitors in the clinics.
authors.affiliation: German Cancer Research Center (DKFZ), Research Group Innate Immunity, Heidelberg, Germany.
authors.forename: Jing
authors.initials: J
authors.lastname: Ni
authors.affiliation: German Cancer Research Center (DKFZ), Research Group Innate Immunity, Heidelberg, Germany. a.cerwenka@dkfz.de.
authors.forename: Adelheid
authors.initials: A
authors.lastname: Cerwenka
mesh_terms: D006801:Humans; D007694:Killer Cells, Natural