title: Hemodynamics of mesenteric traction syndrome measured by FloTrac sensor.
abstract: BACKGROUND
  Mesenteric traction syndrome (MTS) develops in the early phase of laparotomy, which is triggered by pulling of the mesentery. We attempted to analyze the circulatory dynamics of MTS by using the FloTrac sensor.
  
  
  METHODS
  Prospective randomized control study, the MTS trial, was conducted with or without prophylactic administration of flurbiprofen axetil in order to control MTS development in 57 elective open colorectal surgeries. None of the Flurbipurofen group patients (n = 23) develop MTS and were allocated to the non-MTS group. Among the non-flurbiprofen group, 28 patients (82%) developed MTS and were categorized into the MTS group. For these patients, in addition to blood pressure, stroke volume variation (SVV) and systemic vascular resistance index (SVRI) were measured by FloTrac sensor.
  
  
  RESULTS
  The lowest blood pressure was noted within 30 minutes from the beginning of the intra-abdominal examination; in the non-MTS group, the mean blood pressure decreased by 16.7%, and in the MTS group, it decreased by 34.2% (P < .01). SVV of the 28 MTS patients was as follows: <9% in 10 patients (35.7%), >9% and <13% in 8 patients (28.6%), and >13% in 10 patients (35.7%). SVRI rose in the non-MTS group by 5.1%, whereas it fell in the MTS group by 15.1% (P < .01), indicating the close relationship between MTS and SVRI.
  
  
  CONCLUSIONS
  The SVV results indicate that fluid loading is not that optimal treatment against hypotension of MTS and that it is also important to consider the use of a vasoconstrictor. FloTrac is therefore useful for making an appropriate decision on the treatment strategy for MTS.
authors.affiliation: Department of Anesthesiology, Tokyo Metropolitan Bokutoh Hospital, 4-23-15, Koto-bashi, Sumida-ku, Tokyo 130-8575, Japan. Electronic address: bokutouma@yahoo.co.jp.
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Dai
authors.initials: D
authors.lastname: Shida
authors.affiliation: Department of Anesthesiology, Tokyo Metropolitan Bokutoh Hospital, 4-23-15, Koto-bashi, Sumida-ku, Tokyo 130-8575, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tagawa
authors.affiliation: Department of Anesthesiology, Tokyo Metropolitan Bokutoh Hospital, 4-23-15, Koto-bashi, Sumida-ku, Tokyo 130-8575, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001794:Blood Pressure; D015179:Colorectal Neoplasms / Q000601:surgery; D005260:Female; D005480:Flurbiprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D007431:Intraoperative Complications / Q000517:prevention & control; D007813:Laparotomy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008643:Mesentery / Q000473:pathology*; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D011446:Prospective Studies; D013318:Stroke Volume; D013577:Syndrome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005480:Flurbiprofen; C504422:flurbiprofen axetil
keywords: Fluid loading; Flurbiprofen axetil; Stroke volume variation