title: Hepcidin in the diagnosis of iron disorders.
abstract: The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.
authors.affiliation: Section of Internal Medicine, Department of Medicine, University of Verona, Veneto Region Referral Center for Iron Metabolism Disorders, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy;
authors.forename: Domenico
authors.identifier: 0000-0001-9684-1899
authors.initials: D
authors.lastname: Girelli
authors.affiliation: Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; and.
authors.forename: Elizabeta
authors.identifier: 0000-0002-3477-2397
authors.initials: E
authors.lastname: Nemeth
authors.affiliation: Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Dorine W
authors.identifier: 0000-0002-1040-9446
authors.initials: DW
authors.lastname: Swinkels
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods; D019937:Diagnostic Techniques and Procedures; D006403:Hematologic Tests; D064451:Hepcidins / Q000097:blood / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D019189:Iron Metabolism Disorders / Q000097:blood / Q000175:diagnosis* / Q000628:therapy
chemical_list: D015415:Biomarkers; D064451:Hepcidins