title: Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis.
abstract: Cancer genotype-specific synthetic lethal vulnerabilities represent promising therapeutic targets. In this issue of Cancer Discovery, Ogiwara and colleagues uncover a synthetic lethal relationship between two histone acetyl transferase paralogs, CBP and p300, highlighting that cancer cells deficient in CBP are uniquely sensitized to genetic and chemical inhibition of p300.
authors.affiliation: Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Cigall_kadoch@dfci.harvard.edu.
authors.forename: Cigall
authors.initials: C
authors.lastname: Kadoch
mesh_terms: D051548:Histone Acetyltransferases; D006657:Histones; D006801:Humans; D017770:Lifting; D050880:p300-CBP Transcription Factors
chemical_list: D006657:Histones; D051548:Histone Acetyltransferases; D050880:p300-CBP Transcription Factors