title: Fetal abnormalities leading to termination of twin pregnancies: the 17-year experience of a single medical center.
abstract: OBJECTIVE
  To assess fetal abnormalities leading to termination of pregnancy (TOP) performed in twin pregnancies.
  
  
  METHODS
  The current study consisted of all women with dichorionic twin pregnancies (study group) who underwent TOP due to fetal abnormalities in our institute from 1999 to 2015. The data were compared to our registry of all parturient women with a singleton pregnancy (control group) that underwent TOP due to fetal anomalies at the same period.
  
  
  RESULTS
  There were 2495 cases of TOP because of fetal indications during the study period. Of them, 86 (3.4%) and 2409 (96.6%) were from the study and control group, respectively. Structural anomalies were the leading indication for TOP in twins compared with singleton pregnancies (81.4% versus 50.9%, respectively, p < 0.0001). For twins, the leading indication for TOP was central nervous system (CNS) abnormalities and it was more common compared with singleton pregnancies (26.1% versus 12.2%, respectively, p < 0.0001). This was followed by chromosomal/genetic abnormalities (16.3% versus 40.4%, respectively, p < 0.0001).
  
  
  CONCLUSIONS
  We found a different distribution for fetal anomalies leading to TOP in twins versus singleton pregnancies. The main indication for TOP in the study group was structural malformations, with a predominance of CNS abnormalities.
authors.affiliation: a Department of Obstetrics and Gynecology , Assaf Harofeh Medical Center , Zerifin , Israel.
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Melcer
authors.affiliation: a Department of Obstetrics and Gynecology , Assaf Harofeh Medical Center , Zerifin , Israel.
authors.forename: Ran
authors.initials: R
authors.lastname: Svirsky
authors.affiliation: a Department of Obstetrics and Gynecology , Assaf Harofeh Medical Center , Zerifin , Israel.
authors.forename: Zvi
authors.initials: Z
authors.lastname: Vaknin
authors.affiliation: a Department of Obstetrics and Gynecology , Assaf Harofeh Medical Center , Zerifin , Israel.
authors.forename: Orna
authors.initials: O
authors.lastname: Levinsohn-Tavor
authors.affiliation: a Department of Obstetrics and Gynecology , Assaf Harofeh Medical Center , Zerifin , Israel.
authors.forename: Noa
authors.initials: N
authors.lastname: Feldman
authors.affiliation: a Department of Obstetrics and Gynecology , Assaf Harofeh Medical Center , Zerifin , Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Maymon
mesh_terms: D000025:Abortion, Eugenic / Q000706:statistics & numerical data*; D000328:Adult; D016022:Case-Control Studies; D000013:Congenital Abnormalities; D005260:Female; D006801:Humans; D011247:Pregnancy; D059285:Pregnancy, Twin; D012042:Registries; D012189:Retrospective Studies
keywords: Anomaly scan; chromosomal abnormalities; fetal anomalies; termination of pregnancy; twins