title: Six Cases of Pulmonary Mycobacterium shinjukuense Infection at a Single Hospital.
abstract: Mycobacterium shinjukuense lung disease was diagnosed in 3 men and 3 women [mean age: 77.0±12.2 (57-93) years]. On imaging, 3 patients with previous pulmonary tuberculosis exhibited a fibrocavitary pattern, while the other 3 patients showed nodular bronchiectasis. A test with a tuberculosis rRNA identification kit (TRC Rapid(®) M. TB) was falsely positive for M. tuberculosis due to DNA sequence similarity in 16SrRNA. M. shinjukuense was identified by the gene sequences of rpoB, 16S rRNA, and hsp65. The symptoms and imaging findings of most of the patients have improved with chemotherapy with low minimum inhibitory concentrations of anti-tuberculosis drugs.
authors.affiliation: Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Takeda
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Ohshima
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nagai
authors.forename: Ryota
authors.initials: R
authors.lastname: Sato
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ando
authors.forename: Kei
authors.initials: K
authors.lastname: Kusaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawashima
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Masuda
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Matsui
authors.forename: Akio
authors.initials: A
authors.lastname: Aono
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Chikamatsu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mitarai
authors.forename: Ken
authors.initials: K
authors.lastname: Ohta
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology*; D012336:RNA, Ribosomal, 16S / Q000235:genetics
chemical_list: D012336:RNA, Ribosomal, 16S