title: Laryngeal Cancer: 12-Year Experience of a Single Center.
abstract: Laryngeal cancer is about the twentieth most common cancer in the world and more than 150,000 new cases are diagnosed annually. The aim of the study was to evaluate the history, diagnostics, treatment outcomes, and prognosis in patients with laryngeal cancer in Northern Slovakia. We analyzed retrospectively 227 patients (207 males, 20 females) with laryngeal carcinoma treated in the period 2003-2014 at the Clinic of Otorhinolaryngology and Head and Neck Surgery of the Jessenius Faculty of Medicine and Martin University Hospital in Martin, Slovakia. The majority of patients were in the sixth (38.0 %) and seventh decade of life (30.8 %). Two hundred and seventeen patients (95.6 %) were smokers or ex-smokers. Sixty-six percent of patients were diagnosed with glottic or transglottic carcinoma, related probably to the anatomical structure of the larynx and exposure to inhalation pollutants. It is alarming that the majority of patients with malignant laryngeal disease were admitted to the hospital in advanced stages. In 151 (66.5 %) of patients, the extent of infiltration was T3 or T4, and 156 (68 %) patients were in disease stage III and IV. The incidence and mortality of laryngeal cancer suggest the need to intensify the prevention and to search for an early clinical stage of laryngeal cancer using a targeted screening.
authors.affiliation: Clinic of Otorhinolaryngology and Head and Neck Surgery, Jessenius Faculty of Medicine, Comenius University and Martin University Hospital, 2 Kollarova St., 036 01, Martin, Slovakia. calkovsky@jfmed.uniba.sk.
authors.forename: V
authors.initials: V
authors.lastname: Calkovsky
authors.affiliation: Clinic of Otorhinolaryngology and Head and Neck Surgery, Jessenius Faculty of Medicine, Comenius University and Martin University Hospital, 2 Kollarova St., 036 01, Martin, Slovakia.
authors.forename: P
authors.initials: P
authors.lastname: Wallenfels
authors.affiliation: Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.|Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Calkovska
authors.affiliation: Clinic of Otorhinolaryngology and Head and Neck Surgery, Jessenius Faculty of Medicine, Comenius University and Martin University Hospital, 2 Kollarova St., 036 01, Martin, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Hajtman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D018154:Slovakia / Q000453:epidemiology; D015996:Survival Rate; D055815:Young Adult
keywords: Carcinoma; Complications; Diagnostics; Laryngectomy; Larynx; Prognosis; Risk factors