title: An unusual karyotype in leiomyoma: Case report and literature review.
abstract: Vascular leiomyoma are uncommon, clinically benign smooth muscle tumors. Here we report a case of an otherwise typical leiomyoma with unusual cytogenetic changes including t(1;10). Reports from the existing literature suggest that approximately 40-50% of leiomyomas contain nonrandom chromosomal abnormalities of which a subset is tumor specific. t(12;14)(q15;q24) is one of the most common translocations, which occur in approximately 20% of karyotypes. Additional aberrations include del(7)(q22-q32), trisomy 12, and 6p21 rearrangements. Other recurrent abnormalities include monosomy 22, monosomy 10, del(10q), and structural rearrangements of chromosome 3.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors.forename: Le
authors.initials: L
authors.lastname: Chang
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors.forename: Nagesh
authors.initials: N
authors.lastname: Rao
authors.affiliation: Department of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Bernthal
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dry
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: James
keywords: Leiomyoma; Leiomyosarcoma; Smooth muscle tumors; t(1 ;10)