title: A multifaceted role for MOF histone modifying factor in genome maintenance.
abstract: MOF (males absent on the first) was initially identified as a dosage compensation factor in Drosophila that acetylates lysine 16 of histone H4 (H4K16ac) and increased gene transcription from the single copy male X-chromosome. In humans, however, the ortholog of Drosophila MOF has been shown to interact with a range of proteins that extend its potential significance well beyond transcription. For example, recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways. Thus, directly or indirectly, MOF may be involved in a wide range of cellular functions. This review will focus on the contribution of MOF to cellular DNA repair and new results that are beginning to examine the in vivo physiological role of MOF.
authors.affiliation: Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, United States.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Mujoo
authors.affiliation: Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, United States.
authors.forename: Clayton R
authors.initials: CR
authors.lastname: Hunt
authors.affiliation: Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, United States.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Horikoshi
authors.affiliation: Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, United States. Electronic address: tpandita@houstonmethodist.org.
authors.forename: Tej K
authors.initials: TK
authors.lastname: Pandita
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle; D041321:Chromosomes, Human, X / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D006801:Humans
chemical_list: D051548:Histone Acetyltransferases; C496552:KAT8 protein, human; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins
keywords: DNA DSB; H4K16ac; HR; MOF; NHEJ; Oncogenesis