title: Tobacco and alcohol consumption after total laryngectomy and survival: A German multicenter prospective cohort study.
abstract: We examined the relation of tobacco and alcohol consumption after total laryngectomy with overall survival (OS).
  
  
  
  Tobacco and alcohol consumption was assessed at 5 time points after total laryngectomy. Patients were followed up for survival until December 31, 2014. A multivariate Cox regression was fitted to test for differences in OS.
  
  
  
  Three hundred fifty-nine patients were included in this study. Compared to former smokers, never smokers had hazard ratios (HRs) of 0.88 (95% confidence intervals [CIs] = 0.50-1.59), and continuous smokers 1.31 (95% CI = 0.87-1.96). Constantly high alcohol consumption after total laryngectomy had an HR of 2.19 (95% CI = 1.30-3.67). Duration of smoking (HR = 1.00; 95% CI = 0.99-1.01) and last known status of alcohol consumption (HR = 1.00; 95% CI = 0.76-1.33) was not related to OS.
  
  
  
  Patients who smoke after total laryngectomy have a 30% higher risk of dying than people who gave up smoking, and constant high alcohol consumption is also a strong risk factor for dying. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1324-1329, 2016.
authors.affiliation: Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University of Mainz, Mainz, Germany.|German Cancer Consortium (DKTK), Heidelberg, Germany.|Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Eichler
authors.affiliation: Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Keszte
authors.affiliation: Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Meyer
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Leipzig, Germany.
authors.forename: Helge
authors.initials: H
authors.lastname: Danker
authors.affiliation: Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.
authors.forename: Orlando
authors.initials: O
authors.lastname: Guntinas-Lichius
authors.affiliation: Department of Otorhinolaryngology, Hospital Chemnitz, Chemnitz, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Oeken
authors.affiliation: Department of Otorhinolaryngology, Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: Friedemann
authors.initials: F
authors.lastname: Pabst
authors.affiliation: Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University of Mainz, Mainz, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Singer
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology; D002423:Cause of Death; D000073865:Cigarette Smoking / Q000009:adverse effects* / Q000453:epidemiology; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005858:Germany; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D016019:Survival Analysis; D014026:Nicotiana
keywords: alcohol; cohort; laryngectomy; smoking; survival