title: Effects of coenzyme Q10 supplementation on C-reactive protein and homocysteine as the inflammatory markers in hemodialysis patients; a randomized clinical trial.
abstract: BACKGROUND
  The most leading cause of death in end-stage renal disease (ESRD) patients are cardiovascular disease and inflammatory markers are related to coronary events. CO-Q10 (coenzyme Q10) is a protective supplement from free radical oxidative damage. In addition, hyperhomocysteinemia is an independent coronary artery disease (CAD) risk factor.
  
  
  OBJECTIVE
  Due to increasing oxidative stress in dialysis patients, and the effect of CO-Q10 in decrease oxidative stress, in this work, we assessed the effect of CO-Q10 on C-reactive protein (CRP) level as an inflammatory marker and homocysteine in dialysis patients.
  
  
  METHODS
  This was a single-blind, randomized cross over clinical trial. Patients with ESRD were randomly allotted to two groups. All patients received placebo and C0- Q10 100mg/d during the three months in each stage, with two week washout period. Plasma level of CRP and homocysteine from the start of the work and at the conclusion of each menses, are evaluated.
  
  
  RESULTS
  Thirty-four patients randomized, but 26 patients complete study protocol. The treatment effect of CO-Q10 on CRP level is significant (P < 0.001) (95% CI = -20.1 to -10.5) and it was also significant for the increasing albumin level. (P = 0.044) (95% CI = 0. 0-0.6), But there was not any substantial effect on serum homocysteine level (P = 0.630).
  
  
  CONCLUSIONS
  CO-Q10 could significantly decrease CRP level as an inflammatory marker and can protect cardiovascular events.
authors.affiliation: Departement of Nephrology, Loghman Hakim Hospital, Shahid-Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Narges-Sadat
authors.initials: NS
authors.lastname: Zahed
authors.affiliation: Department of Internal Medicine, Loghman Hakim Hospital, Shahid-Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghassami
authors.affiliation: Departement of Nephrology, Loghman Hakim Hospital, Shahid-Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hajar
authors.initials: H
authors.lastname: Nikbakht
keywords: C-reactive protein; Coenzyme Q10; Homocysteine; Renal insufficiency