title: [Genes for Fibrogenesis in the Determination of Susceptibility to Myocardial Infarction].
abstract: A group of patients with ischemic heart disease and myocardial infarction (N = 156) and a reference population sample (N = 300) were genotyped for 58 single nucleotide polymorphisms (SNPs) in the genes involved in extracellular matrix function and collagen metabolism or associated with cardiovascular diseases and atherosclerotic plaque stability. Genotyping was performed by mass-spectrometry with two multiplex sets of 27 and 31 SNPs. The study revealed different genetic composition of predisposition to cardiovascular disease continuum (CVDC) syntropy (patients with concomitant conditions: hypercholesterolemia, hypertension, and type-II diabetes mellitus, N = 96) and to isolated myocardial infarction (without these conditions, N = 60). Only the KIAA1462 gene (rs3739998) showed associations with both CVDC syntropy (OR = 1.71; 95% CI 1.19-2.45; р = 0.003) and isolated infarction (OR = 1.58; 95% CI 1.05-2.40; р = 0.028). Isolated myocardial infarction was also associated with LIG1 (rs20579) (OR = 2.08; 95% CI 1.06-4.17; р = 0.028) and ADAMDEC1 (rs3765124) (OR = 1.63; 95% CI 1.07-2.50; р = 0.020). CVDC syntropy was associated with CDKN2BAS1 (rs1333049) (OR = 1.48; 95% CI 1.03-2.12; р = 0.029) and APOA2 (rs5082) (OR = 1.47; 95% CI 1.02-2.11; р = 0.035). So, genes involved in fibrogenesis contribute to predisposition to the myocardial infarction as well. Isolated myocardial infarction and CVDC syntropy can be considered as pathogenetically different cardiovascular conditions, with different genes that contribute to the susceptibility.
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.|Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.|irina.goncharova@medgenetics.ru.
authors.forename: I A
authors.initials: IA
authors.lastname: Goncharova
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.|Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Makeeva
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.|Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Golubenko
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Markov
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Tarasenko
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Sleptsov
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
mesh_terms: D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics* / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
keywords: ADAMDEC1; CDKN2BAS1; KIAA1462; LIG1; MTAP; cardiovascular disease continuum; fibrogenesis; genetics of concomitant diseases; myocardial infarction