title: Mean-field and linear regime approach to magnetic hyperthermia of core-shell nanoparticles: can tiny nanostructures fight cancer?
abstract: The phenomenon of heat dissipation by magnetic materials interacting with an alternating magnetic field, known as magnetic hyperthermia, is an emergent and promising therapy for many diseases, mainly cancer. Here, a magnetic hyperthermia model for core-shell nanoparticles is developed. The theoretical calculation, different from previous models, highlights the importance of heterogeneity by identifying the role of surface and core spins on nanoparticle heat generation. We found that the most efficient nanoparticles should be obtained by selecting materials to reduce the surface to core damping factor ratio, increasing the interface exchange parameter and tuning the surface to core anisotropy ratio for each material combination. From our results we propose a novel heat-based hyperthermia strategy with the focus on improving the heating efficiency of small sized nanoparticles instead of larger ones. This approach might have important implications for cancer treatment and could help improving clinical efficacy.
authors.affiliation: Instituto de Física, Universidade Federal de Goiás, Goiânia, GO 74690-900, Brazil. bakuzis@ufg.br.
authors.forename: Marcus S
authors.initials: MS
authors.lastname: Carrião
authors.affiliation: Instituto de Física, Universidade Federal de Goiás, Goiânia, GO 74690-900, Brazil. bakuzis@ufg.br.
authors.forename: Andris F
authors.initials: AF
authors.lastname: Bakuzis
mesh_terms: D003198:Computer Simulation; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods* / Q000706:statistics & numerical data; D016014:Linear Models; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy*; D010316:Particle Size
chemical_list: D004337:Drug Carriers; D058185:Magnetite Nanoparticles