title: [Epigenetics in allergic diseases and asthma].
abstract: Allergic diseases and asthma are the result of complex interactions between genetic predisposition and environmental factors. Asthma is one of the most prevalent chronic disease among children. In this article we review some environmental factors like: allergen exposition, tobacco, bacteria, microbial components, diet, obesity and stress, which influences during intrauterine and infancy life in the epigenetic regulation of asthma and allergic diseases. The review has been done in three models: in-vitro, animal and human.
authors.affiliation: División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Laboratorio de Programación y Epigenética Perinatal, Centro de Investigaciones Médicas, Santiago, Chile. Electronic address: jacastro17@hotmail.com.
authors.forename: José A
authors.initials: JA
authors.lastname: Castro-Rodríguez
authors.affiliation: Laboratorio de Programación y Epigenética Perinatal, Centro de Investigaciones Médicas, Santiago, Chile; División de Obstetricia y Ginecología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Bernardo J
authors.initials: BJ
authors.lastname: Krause
authors.affiliation: División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Laboratorio de Programación y Epigenética Perinatal, Centro de Investigaciones Médicas, Santiago, Chile.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Uauy
authors.affiliation: División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Laboratorio de Programación y Epigenética Perinatal, Centro de Investigaciones Médicas, Santiago, Chile; División de Obstetricia y Ginecología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Paola
authors.initials: P
authors.lastname: Casanello
mesh_terms: D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000235:genetics; D002648:Child; D004777:Environment; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000235:genetics; D012307:Risk Factors
keywords: Allergic diseases; Asma; Asthma; Children; Enfermedades alérgicas; Environmental factors; Epigenetic; Epigenética; Factores ambientales; In-utero; Niños