title: VISCOSUPPLEMENTATION.
abstract: With the aging of the world's population, the prevalence of age-related diseases is continually increasing, especially osteoarthritis, the most common form of joint disease. In addition to its high prevalence, osteoarthritis has been correlated with high medical and social costs. Among the treatment methods, viscosupplementation (intra-articular injection of hyaluronic acid derivatives) has been gaining more prominence. The substances used are high molecular weight polysaccharides that, in addition to mechanical functions of weight distribution and joint lubrication, have anti-inflammatory properties and physical-chemical action on a variety of joint characteristics. These effects are directly proportional to the molecular weight and concentration of the drug used and any cross-links that may be present in the drug. Viscosupplementation is a simple procedure and can be performed in outpatient clinics. It provides benefits regarding pain and function, and also favorably alters the course of the disease, through quantitatively and qualitatively improving the joint cartilage. It has a good safety profile and favorable cost-effectiveness relationship, and is indicated both for osteoarthritis cases and after an arthroscopic procedure.
authors.affiliation: MSc and PhD in Orthopedics and Traumatology from FMUSP; Head of the Osteometabolic Diseases Group, Institute of Orthopedics and Traumatology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Márcia Uchôa
authors.initials: MU
authors.lastname: de Rezende
authors.affiliation: Postgraduate Student in the Discipline of Orthopedics and Traumatology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Gustavo Constantino
authors.initials: GC
authors.lastname: de Campos
keywords: Hyaluronic Acid/administration & dosage; Hyaluronic Acid/therapeutic use; Osteoarthritis