title: Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss.
abstract: OBJECTIVE
  To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time.
  
  
  METHODS
  Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects.
  
  
  RESULTS
  Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002).
  
  
  CONCLUSIONS
  The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery,Istanbul Gaziosmanpasa Taksim Research and Training Hospital,Istanbul,Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Dinc
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery,Istanbul Gaziosmanpasa Taksim Research and Training Hospital,Istanbul,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ulusoy
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery,Erciş State Hospital,Van,Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Is
authors.affiliation: Department of Medical Biochemistry,Istanbul Gaziosmanpasa Taksim Research and Training Hospital,Istanbul,Turkey.
authors.forename: N N
authors.initials: NN
authors.lastname: Ayan
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery,Istanbul Gaziosmanpasa Taksim Research and Training Hospital,Istanbul,Turkey.
authors.forename: M O
authors.initials: MO
authors.lastname: Avincsal
authors.affiliation: Department of Medical Biochemistry,Dışkapı Yıldırım Bayezit Training and Research Hospital,Ankara,Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Bicer
authors.affiliation: Department of Medical Biochemistry,Dışkapı Yıldırım Bayezit Training and Research Hospital,Ankara,Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D016022:Case-Control Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Disulfides; Hearing Loss; Oxidative Stress; Reactive Oxygen Species; Sudden; Thiols