title: Perioperative circulating tumor cell detection: Current perspectives.
abstract: Primary cancer resections and in selected cases surgical metastasectomies significantly improve survival, however many patients develop recurrences. Circulating tumor cells (CTCs) function as an independent marker that could be used in the prognostication of different cancers. Sampling of blood and bone marrow compartments during cancer resections is a unique opportunity to increase individual tumor cell capture efficiency. This review will address the diagnostic and therapeutic potentials of perioperative tumor isolation and highlight the focus of future studies on characterization of single disseminated cancer cells to identify targets for molecular therapy and immune escape mechanisms.
authors.affiliation: a Hugh E. Stephenson Jr., M.D. , Department of Surgery , University of Missouri , Columbia , MO , USA.|b Ellis Fischel Cancer Center , University of Missouri , Columbia , MO , USA.
authors.forename: Jussuf T
authors.initials: JT
authors.lastname: Kaifi
authors.affiliation: a Hugh E. Stephenson Jr., M.D. , Department of Surgery , University of Missouri , Columbia , MO , USA.|c Department of Molecular Microbiology and Immunology , University of Missouri , Columbia , MO , USA.
authors.forename: Guangfu
authors.initials: G
authors.lastname: Li
authors.affiliation: d Gittlen Cancer Research Foundation and Department of Pathology , Materials Research Institute, Penn State College of Medicine, Pennsylvania State University , Hershey , PA , USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Clawson
authors.affiliation: a Hugh E. Stephenson Jr., M.D. , Department of Surgery , University of Missouri , Columbia , MO , USA.|b Ellis Fischel Cancer Center , University of Missouri , Columbia , MO , USA.|c Department of Molecular Microbiology and Immunology , University of Missouri , Columbia , MO , USA.
authors.forename: Eric T
authors.initials: ET
authors.lastname: Kimchi
authors.affiliation: a Hugh E. Stephenson Jr., M.D. , Department of Surgery , University of Missouri , Columbia , MO , USA.|b Ellis Fischel Cancer Center , University of Missouri , Columbia , MO , USA.|c Department of Molecular Microbiology and Immunology , University of Missouri , Columbia , MO , USA.
authors.forename: Kevin F
authors.initials: KF
authors.lastname: Staveley-O'Carroll
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D010641:Phenotype
keywords: Circulating tumor cells; disseminated tumor cells; metastasectomy; surgery