title: Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy.
abstract: Biomimetic delivery carriers using polypeptide/heparin hybrid nanoparticles that are adsorbed onto red blood cells for extended blood circulation time have been developed. This might open up an avenue to promote the innovations and advances of biomimetic, stimuli-responsive drug delivery, especially for the site-specific treatment of intravascular diseases such as thrombosis.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Chengjun
authors.initials: C
authors.lastname: Chen
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Shukun
authors.initials: S
authors.lastname: Li
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Ma
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. yanxh@ipe.ac.cn.
authors.forename: Xuehai
authors.initials: X
authors.lastname: Yan
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D010455:Peptides; D006493:Heparin
keywords: heparin; nanoparticles; red blood cells; self-assembly; site-specific delivery