title: Comparison of the Control of Nausea and Vomiting among Several Moderately Emetic-Risk Chemotherapy Regimens.
abstract: BACKGROUND
  Different antiemetic medications with or without aprepitant are recommended for moderately emetic-risk chemotherapy (MEC) depending on the emetic potential of chemotherapy agents, although the criterion for the use of aprepitant is still unclear. The present study was designed to compare the control of chemotherapy-induced nausea and vomiting (CINV) among several MEC regimens used in the outpatient chemotherapy setting.
  
  
  METHODS
  A single center prospective observational study was carried out in 326 patients who received 2,061 chemotherapy cycles from January 2013 to December 2014. Antiemetic medication consisting of two-drug combination of granisetron (day 1) and dexamethasone (days 1-3) was carried out in 87.6% of patients receiving the first chemotherapy cycle. The checklist for CINV was provided to all patients, and the control of CINV was evaluated on the next visit based on the checklist. Complete inhibition of nausea and vomiting during acute and delayed periods were compared among MEC regimens.
  
  
  RESULTS
  Two hundred and one patients received the first cycle of chemotherapy, in which the rates of complete inhibition of nausea and vomiting were 87.6% and 95.5%, respectively, during acute period, and 68.2% and 92.0%, respectively, during delayed period. There were no significant differences in the control of CINV among oxaliplatin, carboplatin and irinotecan, except for the cyclophosphamide-base regimen.
  
  
  CONCLUSIONS
  Two-drug antiemetic medication of 5-HT3 receptor antagonist and dexamethasone was sufficiently effective for prevention of CINV in most MEC regimens.
authors.affiliation: 1. Department of Pharmacy, Gifu University Hospital, Gifu, Japan;
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Iihara
authors.affiliation: 1. Department of Pharmacy, Gifu University Hospital, Gifu, Japan;
authors.forename: Masashi
authors.initials: M
authors.lastname: Ishihara
authors.affiliation: 1. Department of Pharmacy, Gifu University Hospital, Gifu, Japan;
authors.forename: Hironori
authors.initials: H
authors.lastname: Fujii
authors.affiliation: 1. Department of Pharmacy, Gifu University Hospital, Gifu, Japan;
authors.forename: Chiaki
authors.initials: C
authors.lastname: Yoshimi
authors.affiliation: 1. Department of Pharmacy, Gifu University Hospital, Gifu, Japan;
authors.forename: Maya
authors.initials: M
authors.lastname: Yamada
authors.affiliation: 1. Department of Pharmacy, Gifu University Hospital, Gifu, Japan;
authors.forename: Akio
authors.initials: A
authors.lastname: Suzuki
authors.affiliation: 2. Department of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamaguchi
authors.affiliation: 2. Department of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Futamura
authors.affiliation: 2. Department of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: 1. Department of Pharmacy, Gifu University Hospital, Gifu, Japan;
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Itoh
keywords: moderately emetic-risk chemotherapy - nausea - vomiting - outpatient cancer chemotherapy.