title: Neolignans from Selaginella moellendorffii.
abstract: Two new neolignans selaginellol (1) and selaginellol 4'-O-β-D-glucopyranoside (2), together with seven known compounds (3-9), were isolated from the whole plant of Selaginella moellendorffii. The structures of the new isolates were determined through spectroscopic data analysis. Compounds 1-9, as well as compounds 10-18 previously isolated from the species, were measured for the activity against platelet aggregation induced by ADP or collagen. Three neoligans (8, 11, and 12), one flavanone (14), and one alkaloid (16) showed inhibitory activity against ADP- or collagen-induced platelet aggregation as compared with tirofiban. The dihydrobenzofuran neolignans (8, 11, and 12) are more potent than the benzofuran neolignan (13) and other types of neolignans (1-7). Glucosidation of the dihydrobenzofuran neolignans (11 and 12) is helpful for the activity. Two new neolignans selaginellol (1) and selaginellol 4'-O-β-D-glucopyranoside (2) were isolated from the whole plant of Selaginella moellendorffii. Several compounds from this plant showed the activity against platelet aggregation induced by ADP or collagen.
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
authors.forename: Jing-Xian
authors.initials: JX
authors.lastname: Zhuo
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. wangyuehu@mail.kib.ac.cn.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.affiliation: School of Life Science & Technology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Xing-Li
authors.initials: XL
authors.lastname: Su
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
authors.forename: Ren-Qiang
authors.initials: RQ
authors.lastname: Mei
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: School of Life Science & Technology, China Pharmaceutical University, Nanjing, 210009, China. yikong668@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Kong
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. long@mail.kib.ac.cn.|College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China. long@mail.kib.ac.cn.
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
keywords: Antiplatelet; Lignans; Selaginella moellendorffii; Selaginellaceae