title: Aggregation-Induced Resonance Raman Optical Activity (AIRROA): A New Mechanism for Chirality Enhancement.
abstract: Raman optical activity (ROA) spectroscopy is hampered by low sensitivity, with limited possibilities for enhancing the signal. In the present study, we report a new mechanism whereby chirality is enhanced using the resonance resulting from supramolecular aggregation. We have named this mechanism aggregation-induced resonance Raman optical activity (AIRROA). As an example, we study J-aggregates of astaxanthin (AXT), which show strong absorption of circularly polarized light in the range of ROA excitation. The implications of aggregation-induced signal enhancement for chiroptical spectroscopy are discussed.
authors.affiliation: Faculty of Chemistry, Jagiellonian University , Ingardena 3, Krakow 30-060, Poland.|Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University , Bobrzynskiego 14, Krakow 30-348, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Zajac
authors.affiliation: Faculty of Chemistry, Jagiellonian University , Ingardena 3, Krakow 30-060, Poland.|Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University , Bobrzynskiego 14, Krakow 30-348, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kaczor
authors.affiliation: Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University , Bobrzynskiego 14, Krakow 30-348, Poland.
authors.forename: Ana
authors.initials: A
authors.lastname: Pallares Zazo
authors.affiliation: Faculty of Chemistry, Jagiellonian University , Ingardena 3, Krakow 30-060, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Mlynarski
authors.affiliation: Faculty of Chemistry, Jagiellonian University , Ingardena 3, Krakow 30-060, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Dudek
authors.affiliation: Faculty of Chemistry, Jagiellonian University , Ingardena 3, Krakow 30-060, Poland.|Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University , Bobrzynskiego 14, Krakow 30-348, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Baranska
mesh_terms: D015394:Molecular Structure; D013059:Spectrum Analysis, Raman; D024341:Xanthophylls / Q000737:chemistry
chemical_list: D024341:Xanthophylls; C005948:astaxanthine