title: Relationship between the expression of Notch1 and EZH2 and the prognosis of breast invasive ductal carcinoma.
abstract: We determined whether the coexpression of Notch1 and EZH2 influences the progression and prognosis of breast invasive ductal carcinoma. Using the χ(2) test, a significant difference was found between high and low expression of Notch1 in terms of lymph node, hormone receptor, and p53 expression (P < 0.05). Moreover, a significant difference was found between high and low expression of EZH2 in terms of tumor size, histologic grade, hormone receptor, and expression of Ki67 (P < 0.05). Using Pearson correlation analysis, we found a significant positive correlation between Notch1 and EZH2 expression in the tissue samples of breast invasive ductal carcinoma (P = 0.038). High Notch1 and EZH2 expression was associated with poor progression-free survival compared with low expression (PNotch1 = 0.000, 40.3 vs 48.9 months; PEZH2 = 0.000, 40.2 vs 49.9 months). Moreover, we found that high Notch1 and EZH2 expression was associated with poor overall survival compared with low expression (PNotch1 = 0.000, 51.2 vs 56.2 months; PEZH2 = 0.002, 51.7 vs 56.4 months). In conclusion, Notch1 and EZH2 coexpression contributes to the progression and prognosis of breast invasive ductal carcinoma.
authors.affiliation: Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: X
authors.initials: X
authors.lastname: Luan
authors.affiliation: Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D000071221:Enhancer of Zeste Homolog 2 Protein / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008875:Middle Aged; D011379:Prognosis; D051881:Receptor, Notch1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D051881:Receptor, Notch1; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein