title: Core-Shell Chitosan Microcapsules for Programmed Sequential Drug Release.
abstract: A novel type of core-shell chitosan microcapsule with programmed sequential drug release is developed by the microfluidic technique for acute gastrosis therapy. The microcapsule is composed of a cross-linked chitosan hydrogel shell and an oily core containing both free drug molecules and drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles. Before exposure to acid stimulus, the resultant microcapsules can keep their structural integrity without leakage of the encapsulated substances. Upon acid-triggering, the microcapsules first achieve burst release due to the acid-induced decomposition of the chitosan shell. The encapsulated free drug molecules and drug-loaded PLGA nanoparticles are rapidly released within 60 s. Next, the drugs loaded in the PLGA nanoparticles are slowly released for several days to achieve sustained release based on the synergistic effect of drug diffusion and PLGA degradation. Such core-shell chitosan microcapsules with programmed sequential drug release are promising for rational drug delivery and controlled-release for the treatment of acute gastritis. In addition, the microcapsule systems with programmed sequential release provide more versatility for controlled release in biomedical applications.
authors.affiliation: School of Chemical Engineering and ‡State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University , Chengdu 610065, P. R. China.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Yang
authors.affiliation: School of Chemical Engineering and ‡State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University , Chengdu 610065, P. R. China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Ju
authors.affiliation: School of Chemical Engineering and ‡State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University , Chengdu 610065, P. R. China.
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Mu
authors.affiliation: School of Chemical Engineering and ‡State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University , Chengdu 610065, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Chemical Engineering and ‡State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University , Chengdu 610065, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xie
authors.affiliation: School of Chemical Engineering and ‡State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University , Chengdu 610065, P. R. China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering and ‡State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University , Chengdu 610065, P. R. China.
authors.forename: Liang-Yin
authors.initials: LY
authors.lastname: Chu
mesh_terms: D002214:Capsules; D048271:Chitosan / Q000737:chemistry*; D065546:Drug Liberation; D019344:Lactic Acid; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D002214:Capsules; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D048271:Chitosan
keywords: PLGA; chitosan; microcapsulesc; nanoparticles; programmed sequential drug release