title: Effects of Sulpiride on True and False Memories of Thematically Related Pictures and Associated Words in Healthy Volunteers.
abstract: Episodic memory, working memory, emotional memory, and attention are subject to dopaminergic modulation. However, the potential role of dopamine on the generation of false memories is unknown. This study defined the role of the dopamine D2 receptor on true and false recognition memories. Twenty-four young, healthy volunteers ingested a single dose of placebo or 400 mg oral sulpiride, a dopamine D2-receptor antagonist, just before starting the recognition memory task in a randomized, double-blind, and placebo-controlled trial. The sulpiride group presented more false recognitions during visual and verbal processing than the placebo group, although both groups had the same indices of true memory. These findings demonstrate that dopamine D2 receptors blockade in healthy volunteers can specifically increase the rate of false recognitions. The findings fit well the two-process view of causes of false memories, the activation/monitoring failures model.
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Regina V
authors.initials: RV
authors.lastname: Guarnieri
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Rafaela L
authors.initials: RL
authors.lastname: Ribeiro
authors.affiliation: Associação Fundo de Incentivo à Pesquisa , São Paulo , Brazil.
authors.forename: Altay A Lino
authors.initials: AA
authors.lastname: de Souza
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: José Carlos F
authors.initials: JC
authors.lastname: Galduróz
authors.affiliation: Department of Physiology, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Luciene
authors.initials: L
authors.lastname: Covolan
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Orlando F A
authors.initials: OF
authors.lastname: Bueno
keywords: amygdala; dopamine; dopamine D2 receptor; false recognition; sulpiride; true recognition