title: Atypical Fibroxanthoma in a 13-Year-Old Guatemalan Girl with Xeroderma Pigmentosum.
abstract: Xeroderma pigmentosum (XP) is a rare, autosomal recessive disease involving a defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma (AFX) is a neoplasm typically found in the setting of extensive sun exposure or therapeutic radiation, AFXs are rarely associated with children with XP. We report the case of a 13-year-old Guatemalan girl with the XP type C variant who developed one of the largest AFXs reported on a child's finger.
authors.affiliation: Division of Plastic Surgery, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: Ava G
authors.identifier: http://orcid.org/0000-0003-4096-5459
authors.initials: AG
authors.lastname: Chappell
authors.affiliation: Division of Dermatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Elizabeth P
authors.initials: EP
authors.lastname: Chase
authors.affiliation: Department of Anesthesiology, Stanford University, Stanford, California.
authors.forename: Beverly
authors.initials: B
authors.lastname: Chang
authors.affiliation: Comprehensive Dermatology Group, Encinitas, California.
authors.forename: Eric
authors.initials: E
authors.lastname: Cunningham
authors.affiliation: Department of Anesthesiology, Stanford University, Stanford, California.
authors.forename: Fred
authors.initials: F
authors.lastname: Mihm
authors.affiliation: Compass Dermatopathology, La Jolla, California.|Department of Dermatology, University of California, San Diego, San Diego, California.
authors.forename: Antoanella
authors.initials: A
authors.lastname: Calame
authors.affiliation: Department of Plastic Surgery, University of Washington, Seattle, Washington.
authors.forename: Gary
authors.initials: G
authors.lastname: Fudem
authors.affiliation: Comprehensive Dermatology Group, Encinitas, California.|Department of Dermatology, University of California, San Diego, San Diego, California.
authors.forename: Bari
authors.initials: B
authors.lastname: Cunningham
mesh_terms: D000293:Adolescent; D000671:Amputation, Surgical / Q000379:methods; D001707:Biopsy, Needle; D005260:Female; D005385:Fingers / Q000473:pathology / Q000601:surgery*; D006166:Guatemala; D006801:Humans; D007150:Immunohistochemistry; D011230:Precancerous Conditions / Q000473:pathology*; D035583:Rare Diseases; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D014972:Xanthogranuloma, Juvenile / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000473:pathology* / Q000601:surgery