title: Spontaneous Regression of Hepatocellular Carcinoma with Multiple Lung Metastases: A Case Report and Review of the Literature.
abstract: Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event. Here we present a case of spontaneous regression of metastatic HCC. A 53-year-old man with hepatitis C and alcoholic cirrhosis was found to have a large liver mass consistent with HCC based on its radiographic features. Imaging also revealed left portal and hepatic vein thrombosis, as well as multiple lung nodules concerning for metastases. Approximately 2 months after the initial diagnosis, both the primary liver lesion and the lung metastases decreased in size and eventually resolved without any intervention. Thereafter, the left hepatic vein thrombus progressed into the inferior vena cava and the right atrium, and the patient died due to right heart failure. In this case report and literature review, we discuss the potential mechanisms for and review the literature on spontaneous regression of metastatic HCC.
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.|Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Eirini
authors.initials: E
authors.lastname: Pectasides
authors.affiliation: Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Miksad
authors.affiliation: University of Ottawa, Ottawa, ON, USA.
authors.forename: Sergey
authors.initials: S
authors.lastname: Pyatibrat
authors.affiliation: Metrowest Radiology Associates, Framingham, MA, USA.
authors.forename: Amogh
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: Beth Israel Deaconess Medical Center, Boston, MA, USA. abullock@bidmc.harvard.edu.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bullock
mesh_terms: D006502:Budd-Chiari Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary; D017809:Fatal Outcome; D006333:Heart Failure / Q000209:etiology; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055613:Multiple Pulmonary Nodules / Q000000981:diagnostic imaging* / Q000556:secondary; D011169:Portal Vein; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed; D000072258:Tumor Hypoxia; D014463:Ultrasonography; D014682:Vena Cava, Inferior; D020246:Venous Thrombosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins
keywords: Metastatic hepatocellular carcinoma; Spontaneous regression