title: Myocardial Ischemia Induces SDF-1α Release in Cardiac Surgery Patients.
abstract: In the present observational study, we measured serum levels of the chemokine stromal cell-derived factor-1α (SDF-1α) in 100 patients undergoing cardiac surgery with cardiopulmonary bypass at seven distinct time points including preoperative values, myocardial ischemia, reperfusion, and the postoperative course. Myocardial ischemia triggered a marked increase of SDF-1α serum levels whereas cardiac reperfusion had no significant influence. Perioperative SDF-1α serum levels were influenced by patients' characteristics (e.g., age, gender, aspirin intake). In an explorative analysis, we observed an inverse association between SDF-1α serum levels and the incidence of organ dysfunction. In conclusion, time of myocardial ischemia was identified as the key stimulus for a significant upregulation of SDF-1α, indicating its role as a marker of myocardial injury. The inverse association between SDF-1α levels and organ dysfunction association encourages further studies to evaluate its organoprotective properties in cardiac surgery patients.
authors.affiliation: Department of Plastic Surgery, Hand Surgery, Burn Center, RWTH Aachen University, Aachen, Germany.
authors.forename: Bong-Sung
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Intensive Care Medicine, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Denise
authors.initials: D
authors.lastname: Jacobs
authors.affiliation: Department of Intensive Care Medicine, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Emontzpohl
authors.affiliation: Department of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Goetzenich
authors.affiliation: Department of Intensive Care Medicine, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Josefin
authors.initials: J
authors.lastname: Soppert
authors.affiliation: Department of Intensive Care Medicine, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Jarchow
authors.affiliation: Department of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany.|Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Schindler
authors.affiliation: Department of Intensive Care Medicine, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Luisa
authors.initials: L
authors.lastname: Averdunk
authors.affiliation: Department of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Kraemer
authors.affiliation: Department of Intensive Care Medicine, University Hospital, RWTH Aachen, Aachen, Germany.
authors.forename: Gernot
authors.initials: G
authors.lastname: Marx
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.|Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bernhagen
authors.affiliation: Department of Plastic Surgery, Hand Surgery, Burn Center, RWTH Aachen University, Aachen, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Pallua
authors.affiliation: German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schlemmer
authors.affiliation: German Cancer Research Center (DKFZ), Heidelberg, Germany. simonsd@gmx.de.
authors.forename: David
authors.initials: D
authors.lastname: Simons
authors.affiliation: Department of Intensive Care Medicine, University Hospital, RWTH Aachen, Aachen, Germany. christian.stoppe@gmail.com.
authors.forename: Christian
authors.initials: C
authors.lastname: Stoppe
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015687:Cell Hypoxia; D002478:Cells, Cultured; D054377:Chemokine CXCL12 / Q000097:blood*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12
keywords: Coronary disease; Inflammation; Ischemia; Reperfusion; Stromal cell-derived factor 1 alpha (SDF-1α)