title: Antidepressants and Valvular Heart Disease: A Nested Case-Control Study in Taiwan.
abstract: Empirical evidence regarding the association between antidepressants and valvular heart disease (VHD) is scarce.Using Taiwan's National Health Insurance Research database, this nested case-control study assessed the association between antidepressants and VHD in a Chinese population.Among a cohort of patients who used at least 3 prescription antidepressants, 874 cases with VHD and 3496 matched controls (1:4 ratio) were identified. Conditional logistic regression models were used to examine the timing, duration, dose and type of antidepressants use, and the risk of VHD.Current use of antidepressants was associated with a 1.4-fold increase in the risk of VHD (adjusted odds ratio [aOR] 1.44; 95% confidence interval [CI] 1.17-1.77). Among current users, a dose-response association was observed in terms of the cumulative duration and the cumulative antidepressant dose. Significantly higher risks of VHD were observed among the current users of tricyclic antidepressants (aOR 1.40 [1.05-1.87]).We found that the use of antidepressants was associated with a greater risk of VHD and that the risks varied according to different antidepressants.
authors.affiliation: From the Graduate Institute of Clinical Pharmacy (C-HL, F-YH, L-JS), College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy (F-YH, L-JS), National Taiwan University Hospital, Taipei, Taiwan; School of Pharmacy (F-YH, C-CW, L-JS), College of Medicine, National Taiwan University, Taipei, Taiwan; Cardiovascular Center and Division of Cardiology (Y-BL), Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; and Department of Psychiatry (SS-FG), National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chia-Hui
authors.initials: CH
authors.lastname: Lin
authors.forename: Fei-Yuan
authors.initials: FY
authors.lastname: Hsiao
authors.forename: Yen-Bin
authors.initials: YB
authors.lastname: Liu
authors.forename: Susan Shur-Fen
authors.initials: SS
authors.lastname: Gau
authors.forename: Chi-Chuan
authors.initials: CC
authors.lastname: Wang
authors.forename: Li-Jiuan
authors.initials: LJ
authors.lastname: Shen
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D008297:Male; D018570:Risk Assessment; D013624:Taiwan; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents