title: Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure.
abstract: Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.
authors.affiliation: Institute of Cardiology and Center of Excellence on Aging, 'G. d'Annunzio' University - Chieti, Chieti, Italy Texas Heart Institute, Houston, USA.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Madonna
authors.affiliation: Hubrecht Institute, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Linda W
authors.initials: LW
authors.lastname: Van Laake
authors.affiliation: The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Davidson
authors.affiliation: Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Felix B
authors.initials: FB
authors.lastname: Engel
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
authors.affiliation: MRC Cape Heart Unit, Hatter Cardiovascular Research Institute, University of Cape Town, Cape Town, South Africa.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lecour
authors.affiliation: Neufeld Cardiac Research Institute, Tel-Aviv University, Tel Aviv-Yafo, Israel Tamman Cardiovascular Research Institute, Sheba Medical Center, Tel HaShomer, Israel Sheba Center for Regenerative Medicine, Stem Cell, and Tissue Engineering, Tel Hashomer, Israel.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Leor
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Perrino
authors.affiliation: Institute of Physiology, Justus-Liebig Giessen University of Giessen, Gießen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Schulz
authors.affiliation: Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
authors.forename: Kirsti
authors.initials: K
authors.lastname: Ytrehus
authors.affiliation: Department of Cardiology, Charite Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Ulf
authors.initials: U
authors.lastname: Landmesser
authors.affiliation: Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Mummery
authors.affiliation: Department of Cardiovascular Sciences, Clinical Cardiology, KU Leuven, Leuven, Belgium.
authors.forename: Stefan
authors.initials: S
authors.lastname: Janssens
authors.affiliation: Department of Cardiology, Texas Heart Institute, Houston, TX, USA.
authors.forename: James
authors.initials: J
authors.lastname: Willerson
authors.affiliation: Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Eschenhagen
authors.affiliation: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Pharmahungary Group, Szeged, Hungary j.sluijter@umcutrecht.nl peter.ferdinandy@pharmahungary.com.
authors.forename: Péter
authors.initials: P
authors.lastname: Ferdinandy
authors.affiliation: University Medical Center Utrecht, Utrecht, The Netherlands j.sluijter@umcutrecht.nl peter.ferdinandy@pharmahungary.com.
authors.forename: Joost P G
authors.initials: JP
authors.lastname: Sluijter
mesh_terms: D058948:Cell Tracking / Q000379:methods; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002986:Clinical Trials as Topic; D000068598:Data Accuracy; D004992:Ethics, Medical; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy*; D061214:Patient Safety; D018579:Patient Selection; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation / Q000379:methods; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome
keywords: Cell-based therapy; Heart Failure; Heart Regeneration; Heart repair; Ischaemic heart disease