title: Effects of Wuzhi capsule on blood concentration of tacrolimus after renal transplantation.
abstract: This study aimed to investigate the effects of Wuzhi capsule on blood concentration of tacrolimus after renal transplantation. Sixty patients after allogenic renal transplantation were enrolled in this study and randomly divided into an experimental group and a control group. One oral Wuzhi capsule was taken in the morning and evening for patients in the experimental group, while none was given to the control group, maintaining the trough blood concentration of tacrolimus in the normal range. After 3 weeks, the changes of tacrolimus dosage and hepatorenal function in the two groups were compared. Comparisons of drug dosage and blood concentration C0 value of tacrolimus before initiating the experiment showed that there was no statistically ignificant difference (P>0.05) between the two groups. The differences of blood concentration of tacrolimus and hepatorenal function for patients in both two groups after 3 weeks treatment also showed no statistical significance (P>0.05), whereas a statistically significant decrease was demonstrated in the tacrolimus dosage of the Wuzhi capsule group compared with that of the control group (P=0.0083). After renal transplantation, Wuzhi capsules were added so as to enable tacrolimus to reach a suitable blood concentration, which can prevent the occurrence of renal transplantation rejection, thus alleviating the economic burden of patients and producing larger social benefits.
authors.affiliation: Nephrology Center, Peoples Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.affiliation: Nephrology Center, Peoples Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: Q S
authors.initials: QS
authors.lastname: Qu
authors.affiliation: Nephrology Center, Peoples Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhang
authors.affiliation: Nephrology Center, Peoples Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Miao
authors.affiliation: Nephrology Center, Peoples Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: X
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D016030:Kidney Transplantation; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016559:Tacrolimus / Q000009:adverse effects / Q000097:blood*; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; C582515:wuzhi; D016559:Tacrolimus