title: A comprehensive profile of recurrent glioblastoma.
abstract: In spite of relentless efforts to devise new treatment strategies, primary glioblastomas invariably recur as aggressive, therapy-resistant relapses and patients rapidly succumb to these tumors. Many therapeutic agents are first tested in clinical trials involving recurrent glioblastomas. Remarkably, however, fundamental knowledge on the biology of recurrent glioblastoma is just slowly emerging. Here, we review current knowledge on recurrent glioblastoma and ask whether and how therapies change intra-tumor heterogeneity, molecular traits and growth pattern of glioblastoma, and to which extent this information can be exploited for therapeutic decision-making. We conclude that the ability to characterize and predict therapy-induced changes in recurrent glioblastoma will determine, whether, one day, glioblastoma can be contained in a state of chronic disease.
authors.affiliation: Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Campos
authors.affiliation: Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
authors.forename: L R
authors.initials: LR
authors.lastname: Olsen
authors.affiliation: Department of Radiation Biology, Finsen Center, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Urup
authors.affiliation: Department of Radiation Biology, Finsen Center, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: H S
authors.initials: HS
authors.lastname: Poulsen
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D000066491:Clinical Decision-Making; D003131:Combined Modality Therapy; D023281:Genomics / Q000379:methods; D005909:Glioblastoma / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009364:Neoplasm Recurrence, Local; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D057285:Precision Medicine; D011379:Prognosis; D059016:Tumor Microenvironment