title: The IL-17A/IL-17RA axis in pulmonary defence and immunopathology.
abstract: The interleukin (IL)-17A/IL-17 receptor A (IL-17RA) axis is emerging as a key player in host defence. Several studies have demonstrated that IL-17A-mediated responses play a critical role in both acute and chronic inflammation induced by infectious agents, environmental stimuli and genetic diseases in the airways. In this regard, it is becoming evident that IL-17A/IL-17RA signalling may have a protective and beneficial impact on health, but that it can also result in detrimental outcomes. On one hand, the IL-17A/IL-17RA axis can contribute to the elimination of noxious stimuli and to the resolution of acute inflammatory processes; on the other hand, it can exacerbate immunopathological responses, contributing to the development and progression of chronic respiratory illnesses. In addition, cellular and molecular signatures underlying IL-17A/IL-17RA signalling have been increasingly identified, although further studies are needed to clarify such complex responses. Here, we discuss the latest discoveries on the role of the IL-17A/IL-17RA axis in driving host pulmonary defence and immunopathology.
authors.affiliation: Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy. Electronic address: lore.nicolaivan@hsr.it.
authors.forename: Nicola Ivan
authors.initials: NI
authors.lastname: Lorè
authors.affiliation: Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bragonzi
authors.affiliation: Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Cigana
mesh_terms: D000818:Animals; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D008168:Lung / Q000276:immunology*; D008171:Lung Diseases / Q000276:immunology; D053722:Receptors, Interleukin-17 / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology; D015398:Signal Transduction
chemical_list: C508717:IL17A protein, human; C109985:IL17RA protein, human; D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: Host defence; Immunopathology; Interleukin (IL)-17 receptor A; Interleukin (IL)-17A