title: The Preventive Effect of Zuogui Wan on Offspring Rats' Impaired Glucose Tolerance Whose Mothers Had Gestational Diabetes Mellitus.
abstract: In this experiment, we used streptozotocin (STZ) to establish a model of gestational diabetes mellitus (GDM) rats, where Zuogui Wan was given to GDM rats. After pregnancy, offspring rats were divided into 4 groups: control group, high fat and sugar as the control group, GDM group, and Zuogui Wan GDM group. Rats in high fat and sugar as the control group, GDM group, and Zuogui Wan GDM group were fed with high fat and sugar diet. Rats in control group were fed the basic diet. The means of 2hPG were higher than 7.8 mmol·L(-1) and lower than 11.1 mmol·L(-1) on the rats of GDM group on week 15, and IGT models were successful. Body weight, abdominal fat weight, the ratio of abdominal fat weight and body weight, fasting plasma glucose, 2hPG, insulin, leptin, total cholesterol, and low density lipoprotein (LDL) of Zuogui Wan GDM group were significantly lower than GDM group. The level of adiponectin in Zuogui Wan GDM group was significantly higher than GDM group. And we concluded that giving Zuogui Wan to GDM rats can have a preventive effect on the offsprings' IGT induced by high fat and sugar diet.
authors.affiliation: Beijing University of Chinese Medicine, No. 11 Beisanhuan Donglu, Chaoyang District, Beijing 100029, China.
authors.forename: Yuwei
authors.identifier: 0000-0003-4999-5152
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Beijing University of Chinese Medicine, No. 11 Beisanhuan Donglu, Chaoyang District, Beijing 100029, China; Shanxi University of Traditional Chinese Medicine, No. 121 Daxue Street, Gaoxiaoyuan District, Taiyuan, Shanxi 030619, China.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Feng
authors.affiliation: Beijing University of Chinese Medicine, No. 11 Beisanhuan Donglu, Chaoyang District, Beijing 100029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Niu
authors.affiliation: Shanxi University of Traditional Chinese Medicine, No. 121 Daxue Street, Gaoxiaoyuan District, Taiyuan, Shanxi 030619, China.
authors.forename: Kaixia
authors.initials: K
authors.lastname: Xu
authors.affiliation: Shanxi University of Traditional Chinese Medicine, No. 121 Daxue Street, Gaoxiaoyuan District, Taiyuan, Shanxi 030619, China.
authors.forename: Yingli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanxi University of Traditional Chinese Medicine, No. 121 Daxue Street, Gaoxiaoyuan District, Taiyuan, Shanxi 030619, China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Zhejiang University, Hangzhou, Zhejiang 310058, China.
authors.forename: Qiuju
authors.identifier: 0000-0003-1524-7586
authors.initials: Q
authors.lastname: Li
authors.affiliation: Beijing University of Chinese Medicine, No. 11 Beisanhuan Donglu, Chaoyang District, Beijing 100029, China.
authors.forename: Yingqiu
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Shuangrong
authors.initials: S
authors.lastname: Gao