title: Advance in the study on p38 MAPK mediated drug resistance in leukemia.
abstract: Leukemia is a group of malignant clone diseases of hematopoietic stem cells, while drug resistance (DR) has become the primary cause of chemotherapy failure. p38 mitogen-activated protein kinase (p38MAPK) signaling pathway induces cell activation, proliferation and apoptosis in response to extracellular stimuli. Recent studies have shown that p38 MAPK signaling pathway is closely associated with DR in leukemia. The present article reviews the relationship between p38 MAPK signaling pathway and DR in leukemia.
authors.affiliation: Department of Pediatrics of Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan Province, China. liuwenjunsc@163.com.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.forename: W-J
authors.initials: WJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000502:physiology*; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000201:enzymology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D048051:p38 Mitogen-Activated Protein Kinases