title: [Functional and laboratory characteristics in the concomitance of asthma and obesity at a young age].
abstract: OBJECTIVE
  To study the peripheral blood level of leptin and adiponectin and their possible effect on the functional status of the respiratory system in young asthmatic patients in relation to body mass index (BMI) for the optimization of asthma therapy.
  
  
  METHODS
  Examinations were made in 133 people, including a study group of 93 patients with asthma who were divided into 2 groups according to BMI: 1) those with a BMI of less 25 kg/m2 and 2) those with a BMI of 30 kg/m2 or more, as well as a control group of 40 apparently healthy patients. The investigators studied external respiratory function (ERF), the peripheral blood levels of leptin and adiponectin, the biochemical composition of plasma, by determining total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides.
  
  
  RESULTS
  Lipid metabolic disorders as dyslipidemia and hypercholesterolemia, increased severity of disease, and decreased ERF were recorded in the concomitance of obesity and asthma. The peripheral blood level of leptin in young asthmatic patients with obesity was found to be associated with higher BMI.
  
  
  CONCLUSIONS
  A more severe course of disease presenting with decreased ERF, impaired lipid metabolism, and elevated peripheral blood leptin levels were noted in the concomitance of asthma and obesity at a young age.
authors.affiliation: Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia; Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Sobko
authors.affiliation: Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Solovyeva
authors.affiliation: Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Demko
authors.affiliation: Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Kraposhina
authors.affiliation: Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia; Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia.
authors.forename: O P
authors.initials: OP
authors.lastname: Ishchenko
authors.affiliation: Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Razzakova
authors.affiliation: Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Egorov
authors.affiliation: Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Vtyurina
authors.affiliation: Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Prugova
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001249:Asthma / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D015992:Body Mass Index; D015897:Comorbidity; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin