title: The role of vitamin B1-B2 and plasma lipid profile in intrahepatic cholestasis of pregnancy.
abstract: OBJECTIVE
  The present study aimed to determine the levels of total cholesterol, triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL), and vitamins B1 and B2 in intrahepatic cholestasis of pregnancy (ICP) patients, and to evaluate if these were involved in the pathophysiology of the disease.
  
  
  METHODS
  The prospective randomized study included 35 pregnant patients who were admitted to the Gynecology and Obstetrics Polyclinic, Faculty of Medicine at Dicle University and who were diagnosed with ICP (Group 1), and 40 healthy pregnant women who were admitted in the same period and who had no systemic diseases that might complicate the pregnancy during the pregnancy follow-up (Group 2). Serum lipid levels and vitamins B1 and B2 were determined and compared, and statistical comparisons of the groups were made.
  
  
  RESULTS
  There was no difference between the TG levels of the two groups (P=0.631). Total cholesterol, LDL, HDL, and vitamin B1 and B2 levels were higher in Group 1 than in Group 2 (P=0.001, P=0.001, P=0.001, P=0.001, and P=0.032, respectively).
  
  
  CONCLUSIONS
  Increased levels of vitamins B1 and B2 may indicate a need for increased energy metabolism at the fetus. So we believe that new studies are required, which will be supported by the placental analyses of the pyruvate and lactate levels in maternal blood at delivery and fetal cord blood in order to develop a better understanding on the fetal effects of energy metabolism.
authors.affiliation: .
authors.forename: Serdar
authors.initials: S
authors.lastname: Başaranoğlu
authors.affiliation: .
authors.forename: Elif
authors.initials: E
authors.lastname: Ağaçayak
authors.affiliation: .
authors.forename: Feyzullah
authors.initials: F
authors.lastname: Uçmak
authors.affiliation: .
authors.forename: Senem Yaman
authors.initials: SY
authors.lastname: Tunç
authors.affiliation: .
authors.forename: Aysegül
authors.initials: A
authors.lastname: Deregözü
authors.affiliation: .
authors.forename: Zeynep Meltem
authors.initials: ZM
authors.lastname: Akkurt
authors.affiliation: .
authors.forename: Nurullah
authors.initials: N
authors.lastname: Peker
authors.affiliation: .
authors.forename: Mustafa
authors.initials: M
authors.lastname: Acet
authors.affiliation: .
authors.forename: Hatice
authors.initials: H
authors.lastname: Yüksel
authors.affiliation: .
authors.forename: Talip
authors.initials: T
authors.lastname: Gül
mesh_terms: D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000097:blood* / Q000209:etiology; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000209:etiology; D011446:Prospective Studies; D011897:Random Allocation; D012256:Riboflavin / Q000097:blood*; D013831:Thiamine / Q000097:blood*; D055815:Young Adult
chemical_list: D008055:Lipids; D012256:Riboflavin; D013831:Thiamine
keywords: Cholestasis; lipids; pregnancy; vitamin B1; vitamin B2