title: Monocyte chemoattractant protein 1 and macrophage migration inhibitory factor in children with type 1 diabetes.
abstract: BACKGROUND
  Serum monocyte chemoattractant protein 1 (MCP-1) and macrophage migration inhibitory factor (MIF) could be involved in the pathophysiological process of diabetes. The aim of the study was to evaluate MCP-1 and MIF in patients with diabetes mellitus type 1 (T1DM) and to assess its relation to diabetic control.
  
  
  METHODS
  The study included 39 patients with type 1 diabetes and 38 healthy volunteers. Blood sample was taken for assessment of glycosylated hemoglobin, serum MIF and MCP-1.
  
  
  RESULTS
  Serum MIF and MCP-1 were significantly higher in diabetic cases than in healthy controls. HbA1c levels, were significantly higher in cases than in controls. Serum MIF had a significant positive correlation with serum MCP-1 (r=0.361, p=0.03). No other significant correlation with glycosylated hemoglobin or duration of diabetes was detected.
  
  
  CONCLUSIONS
  A significant increase of serum level of MIF and serum MCP-1 was found in patients with T1DM. These results support that MCP-1 and MIF could be a therapeutic target to treat diabetes and to prevent its complications.
authors.forename: Nagwa Abdallah
authors.initials: NA
authors.lastname: Ismail
authors.forename: Abeer N
authors.initials: AN
authors.lastname: Abd El Baky
authors.forename: Shadia
authors.initials: S
authors.lastname: Ragab
authors.forename: Mona
authors.initials: M
authors.lastname: Hamed
authors.forename: Maha Abo
authors.initials: MA
authors.lastname: Hashish
authors.forename: Abed
authors.initials: A
authors.lastname: Shehata
mesh_terms: D000293:Adolescent; D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008297:Male; D011446:Prospective Studies
chemical_list: D018932:Chemokine CCL2; D006442:Glycated Hemoglobin; D019746:Intramolecular Oxidoreductases; D008263:Macrophage Migration-Inhibitory Factors; C111835:CCL2 protein, human; C517652:hemoglobin A1c protein, human; C515598:MIF protein, human