title: Nuclear imaging potential and in vitro photodynamic activity of symmetrical and asymmetrical zinc phthalocyanines.
abstract: Photodynamic therapy (PDT) is based on exposing a light-sensitive material that has been localized in target tissues with visible light. In the current study, symmetric Zn(II) octaoctadodecylphthalocyanine (1) and the asymmetrically substituted hydroxyhexyloxy derivative (2) were examined as a multifunctional agent for tumour nuclear imaging and for PDT potential. Zn(II)Pc 1 and Zn(II)Pc 2 were radiolabelled with (131) I using an iodogen method with high efficiency (93.5 ± 3.5% and 93.0 ± 2.8%, respectively) under the optimum conditions. Biodistribution study results showed that radiolabelled Zn(II)Pc 1 had a high uptake in the large intestine and unchanging uptake in the ovary. However, radiolabelled Zn(II)Pc 2 uptake was statically significant in the large intestine, pancreas, ovary and lung. For the PDT studies, EMT6/P (mouse mammary cell line) and HeLa (cervical adenocarcinoma cell line) with Zn(II)Pc 1 and Zn(II)Pc 2 were exposed to red light (650 nm) at 10-30 J/cm(2) . Zn(II)Pc 1 and Zn(II)Pc 2 had a good PDT efficacy in the EMT6/P cell line. In conclusion, radiolabelled Zn(II)Pc 1 might be a promising imaging agent for pancreas, ovary and colon tumours. However, the radiolabelled Zn(II)Pc 2 might be a promising nuclear imaging and PDT agent for colon, lung, pancreas and ovary tumours.
authors.affiliation: Department of Nuclear Applications, Institute of Nuclear Science, Ege University, Izmir, Bornova, 35100, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Yurt Lambrecht
authors.affiliation: Advanced Technology Research and Application Center, Mersin University, Ciftlikkoy Campus, Mersin, Yenisehir, TR-33343, Turkey.|Mersin University, Department of Energy Systems Engineering Faculty of Tarsus Technology, Mersin, 33480, Turkey.
authors.forename: Kasim
authors.initials: K
authors.lastname: Ocakoglu
authors.affiliation: Department of Nuclear Applications, Institute of Nuclear Science, Ege University, Izmir, Bornova, 35100, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Er
authors.affiliation: Advanced Technology Research and Application Center, Mersin University, Ciftlikkoy Campus, Mersin, Yenisehir, TR-33343, Turkey.|Mersin University, Department of Energy Systems Engineering Faculty of Tarsus Technology, Mersin, 33480, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Ince
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Bornova, TR-35100, Turkey.
authors.forename: Cumhur
authors.initials: C
authors.lastname: Gunduz
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Bornova, TR-35100, Turkey.
authors.forename: Cagla
authors.initials: C
authors.lastname: Kayabası
mesh_terms: D000818:Animals; D001692:Biological Transport; D003952:Diagnostic Imaging / Q000379:methods*; D004355:Drug Stability; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D054833:Isoindoles; D051379:Mice; D009683:Nuclear Medicine; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D011854:Radiochemistry; D051381:Rats; D014018:Tissue Distribution; D017967:Zinc Compounds
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine
keywords: 131I; asymmetric phthalocyanine; breast cancer cell; photodynamic therapy; symmetric phthalocyanine