title: Association between thromboxane A2 receptor polymorphisms and asthma risk: A meta-analysis.
abstract: To determine whether there is an association between thromboxane A2 receptor (TBXA2R) gene polymorphisms (+924C/T and +795C/T) and asthma risk by conducting a meta-analysis.
  
  
  
  Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang database were searched (updated May 1, 2015).
  
  
  
  Articles evaluating the association between TBXA2R gene polymorphisms and asthma risk were selected.
  
  
  
  A total of 7 studies on +924C/T polymorphism and 6 studies on +795C/T polymorphism were included in this meta-analysis. There was a significant association between TBXA2R +924C/T polymorphism and asthma risk in the recessive model (OR = 1.33, 95% CI = 1.01-1.75, P = 0.045). No significant association between +795C/T polymorphism and asthma risk in the overall population was demonstrated. In subgroup analyzes, significant association was observed in atopic asthma risk in the recessive model (OR = 1.43, 95% CI = 1.01-2.01, P = 0.043), but no significant association was found between TBXA2R +924C/T polymorphism and asthma risk in Asians (OR = 1.14, 95% CI = 0.80-1.63, P = 0.457). TBXA2R +795C/T polymorphism was associated with aspirin-intolerant asthma (AIA) risk when stratified by asthma subphenotype in the allelic model (OR = 1.30, 95% CI = 1.05-1.60, P = 0.014) and dominant model (OR = 1.50, 95% CI = 1.11-2.03, P = 0.008).
  
  
  
  Our results suggested that TBXA2R +924C/T polymorphism is associated with asthma risk, and +795C/T polymorphism may be a risk factor for AIA. Larger-scale and well-designed studies are required to validate the association identified in the current meta-analysis.
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi , China.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Pan
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi , China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Li
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi , China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Xie
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi , China.
authors.forename: Manxiang
authors.initials: M
authors.lastname: Li
mesh_terms: D001249:Asthma / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017594:Publication Bias; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000235:genetics*; D012306:Risk
chemical_list: D044244:Receptors, Thromboxane A2, Prostaglandin H2
keywords: Asthma; genetic; meta-analysis; polymorphism; thromboxane A2 receptor