title: Multiantigenic subunitary vaccines against tuberculosis in clinical trials: Where do we stand and where do we need to go?
abstract: The idea of presenting this commentary is to bring attention to the current status of clinical tests from several multiantigen vaccine candidates based on proteins produced by means of genetic engineering and molecular biology approaches and to suggest how new emerging technologies (OMICs) and bioinformatics might benefit vaccine development for better control of tuberculosis.
authors.affiliation: a Sección de Patología Experimental , Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" , Mexico DF.
authors.forename: Carolina
authors.initials: C
authors.lastname: Guapillo
authors.affiliation: a Sección de Patología Experimental , Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" , Mexico DF.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Hernández-Pando
authors.affiliation: b Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C., Biotecnología Médica y Farmacéutica, Col. Colinas de la Normal , Guadalajara , Jalisco , México.
authors.forename: Mario Alberto
authors.initials: MA
authors.lastname: Flores-Valdez
mesh_terms: D000942:Antigens, Bacterial / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D001500:BCG Vaccine / Q000276:immunology; D002986:Clinical Trials as Topic; D019295:Computational Biology / Q000379:methods; D015195:Drug Design; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000276:immunology*; D022223:Vaccines, Subunit / Q000235:genetics / Q000276:immunology* / Q000592:standards
chemical_list: D000942:Antigens, Bacterial; D001500:BCG Vaccine; D032581:Tuberculosis Vaccines; D022223:Vaccines, Subunit
keywords: clinical trials; multiantigenic; tuberculosis; vaccines