title: Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction.
abstract: OBJECTIVE
  To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI).
  
  
  METHODS
  Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of: MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups.
  
  
  RESULTS
  Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium.
  
  
  CONCLUSIONS
  Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.
authors.affiliation: Universidade da Cidade de São Paulo, Brazil.
authors.forename: Julianne dos Santos
authors.initials: Jdos S
authors.lastname: Maldonado-Menetti
authors.affiliation: Hospital Albert Einstein, Sao Paulo, SP, Brazil.
authors.forename: Taise
authors.initials: T
authors.lastname: Vitor
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, Brazil.
authors.forename: Rodrigo Camargo Leão
authors.initials: RC
authors.lastname: Edelmuth
authors.affiliation: UNICID, Sao Paulo, SP, Brazil.
authors.forename: Fernanda Amá
authors.initials: FA
authors.lastname: Ferrante
authors.affiliation: Universidade Nove de Julho, Sao Paulo, SP, Brazil.
authors.forename: Pamella Ramona de Moraes
authors.initials: PR
authors.lastname: Souza
authors.affiliation: FM, USP, Sao Paulo, SP, Brazil.
authors.forename: Marcia Kiyomi
authors.initials: MK
authors.lastname: Koike
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D005355:Fibrosis; D006333:Heart Failure / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology*; D008168:Lung / Q000473:pathology; D008297:Male; D023421:Models, Animal; D009203:Myocardial Infarction / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000187:drug effects; D009929:Organ Size; D010938:Plant Oils / Q000494:pharmacology*; D017208:Rats, Wistar; D020257:Ventricular Remodeling / Q000187:drug effects*; D017965:gamma-Linolenic Acid / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D010938:Plant Oils; D017965:gamma-Linolenic Acid; C079363:borage oil