title: A new sesquiterpene from the gorgonian coral Menella sp.
abstract: A new sesquiterpene named menecubebane B (1) and a known analogue (2) were isolated from the gorgonian coral Menella sp. Their structures were elucidated by the extensive analyses of spectroscopic data and by the comparison with related literature. Cytotoxic effect against both Eca9706 and HeLa cell lines was evaluated, revealing 1 exhibited moderate cytotoxicity against the two cell lines involved with IC50 values being 20.8 and 30.6 μM, respectively.
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Peng
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Huan
authors.initials: H
authors.lastname: Sun
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Liao
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Mei-Ran
authors.initials: MR
authors.lastname: Feng
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Liu
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Zheng-Xiong
authors.initials: ZX
authors.lastname: Xu
authors.affiliation: b College of science and engineering , Jinan University , Guangzhou , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R.China.
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D012717:Sesquiterpenes; C000592991:menecubebane A; C000619086:menecubebane B
keywords: Gorgonian coral; Menella sp.; cytotoxicity; sesquiterpene