title: The Interplay of Host Immunity, Environment and the Risk of Bacterial Vaginosis and Associated Reproductive Health Outcomes.
abstract: Bacterial vaginosis (BV) is one of the most common causes of vaginal symptoms in US women, but its causal mechanism has not yet been defined. BV is more prevalent in women who are immunosuppressed, and several risk factors for the development of BV are associated with lower quantities of immune mediators in vaginal fluid. In contrast, the poor reproductive health outcomes associated with BV, such as preterm birth and human immunodeficiency virus type 1 acquisition, are associated with increased levels of proinflammatory immune mediators in the genital tract. In this article, we discuss how variations in the host immune profile and environmental effects on host immunity may influence the risk of BV, as well as the risk of complications associated with BV.
authors.affiliation: Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Kerry
authors.initials: K
authors.lastname: Murphy
authors.affiliation: Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Mitchell
mesh_terms: D004777:Environment; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D016867:Immunocompromised Host; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology*; D060728:Reproductive Health; D012307:Risk Factors; D014621:Vagina / Q000276:immunology / Q000382:microbiology; D016585:Vaginosis, Bacterial / Q000150:complications / Q000276:immunology* / Q000382:microbiology
keywords: bacterial vaginosis; mucosal immunity; vaginal microbiota