title: Preclinical Mouse Models for Analysis of the Therapeutic Potential of Engineered Oncolytic Herpes Viruses.
abstract: After more than two decades of research and development, oncolytic herpes viruses (oHSVs) are moving into the spotlight due to recent encouraging clinical trial data. oHSV and other oncolytic viruses function through direct oncolytic cancer cell-killing mechanisms and by stimulating antitumor immunity. As further viruses are developed and optimized for the treatment of various types of cancer, appropriate predictive preclinical models will be of great utility. This review will discuss existing data in this area, focusing on the mouse tumor models that are commonly used.
authors.affiliation: Maria-Carmela Speranza, PhD, is a post-doctoral fellow; Kazue Kasai, PhD, is a Research Specialist; and Sean E. Lawler, PhD, is an Assistant Professor in the Harvey Cushing Neurooncology Laboratories in the Department of Neurosurgery at Brigham and Women's Hospital, Harvard Medical School in Boston, Massachusetts.
authors.forename: Maria-Carmela
authors.initials: MC
authors.lastname: Speranza
authors.affiliation: Maria-Carmela Speranza, PhD, is a post-doctoral fellow; Kazue Kasai, PhD, is a Research Specialist; and Sean E. Lawler, PhD, is an Assistant Professor in the Harvey Cushing Neurooncology Laboratories in the Department of Neurosurgery at Brigham and Women's Hospital, Harvard Medical School in Boston, Massachusetts.
authors.forename: Kazue
authors.initials: K
authors.lastname: Kasai
authors.affiliation: Maria-Carmela Speranza, PhD, is a post-doctoral fellow; Kazue Kasai, PhD, is a Research Specialist; and Sean E. Lawler, PhD, is an Assistant Professor in the Harvey Cushing Neurooncology Laboratories in the Department of Neurosurgery at Brigham and Women's Hospital, Harvard Medical School in Boston, Massachusetts.
authors.forename: Sean E
authors.initials: SE
authors.lastname: Lawler
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008988:Herpestidae / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000628:therapy*; D050504:Oncolytic Viruses / Q000502:physiology*