title: A mild preparation of alkynes from alkenyl triflates.
abstract: We report herein a protocol for preparing alkynes from alkenyl triflates. Stoichiometric LiCl promotes this transformation in DMF at ambient temperature. A range of terminal and internal alkynes were obtained smoothly. A one-pot procedure of alkyne formation/Cu-mediated Huisgen cycloaddition was developed, which may find use in synthesizing natural product-based probes.
authors.affiliation: Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China. hbsun2000@yahoo.com hongbinsun@cpu.edu.cn.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Yang
authors.forename: Dimin
authors.initials: D
authors.lastname: Wu
authors.forename: Zhaohong
authors.initials: Z
authors.lastname: Lu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Sun
authors.forename: Ang
authors.initials: A
authors.lastname: Li