title: Ru(ii) polypyridyl complex-incorporated and folate-conjugated vehicle for cancer cell imaging and photoinduced inactivation.
abstract: Ru(ii) polypyridyl complexes have been expected as promising therapeutic agents against cancer owing to its DNA photocleavage activity. However, the lack of cell selectivity poses a significant obstacle to their practical application. Herein, the strategy combining cell-specific imaging with photoinduced cell death based on [Ru(phen)2(dppz)](2+) has been developed by incorporating [Ru(phen)2(dppz)](2+) into folate-conjugated liposomes. The cells overexpressing folate receptors could specifically recognize this vehicle and be imaged through the luminescence of [Ru(phen)2(dppz)](2+). Thereafter, the delivered [Ru(phen)2(dppz)](2+) interacted with DNA in cells and led to photoinduced cell death. This work provided a possible alternative for cancer diagnosis and therapy.
authors.affiliation: School of Life Science Beijing Institute of Technology, No.5 Yard, Zhong Guan Cun South Street, Haidian District, Beijing, China. hyanxie@bit.edu.cn.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Huang
authors.affiliation: School of Life Science Beijing Institute of Technology, No.5 Yard, Zhong Guan Cun South Street, Haidian District, Beijing, China. hyanxie@bit.edu.cn.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Life Science Beijing Institute of Technology, No.5 Yard, Zhong Guan Cun South Street, Haidian District, Beijing, China. hyanxie@bit.edu.cn.
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Jin
authors.affiliation: School of Life Science Beijing Institute of Technology, No.5 Yard, Zhong Guan Cun South Street, Haidian District, Beijing, China. hyanxie@bit.edu.cn.
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: Zhao
authors.affiliation: School of Life Science Beijing Institute of Technology, No.5 Yard, Zhong Guan Cun South Street, Haidian District, Beijing, China. hyanxie@bit.edu.cn.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Xie
mesh_terms: D000072283:A549 Cells; D016923:Cell Death; D004247:DNA; D005492:Folic Acid / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008081:Liposomes; D049449:Luminescence; D061986:MCF-7 Cells; D009942:Organometallic Compounds / Q000737:chemistry*; D010789:Phototherapy; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D008081:Liposomes; D009942:Organometallic Compounds; D012428:Ruthenium; D004247:DNA; D005492:Folic Acid