title: Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats.
abstract: This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p < 0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p < 0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p < 0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.
authors.affiliation: a Department of Physiology , Faculty of Medicine, Erzincan University , Erzincan , Turkey.
authors.forename: Cebrail
authors.initials: C
authors.lastname: Gürsul
authors.affiliation: b Department of Nutrition and Dietetics , Health Academy, Ağrı İbrahim Çeçen University , Ağrı , Turkey.
authors.forename: Fazile Nur
authors.initials: FN
authors.lastname: Ekinci Akdemir
authors.affiliation: c Department of Physiology , Faculty of Veterinary, Siirt University , Siirt , Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Akkoyun
authors.affiliation: d Department of Histology , Faculty of Medicine, Kafkas University , Kars , Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Can
authors.affiliation: e Department of Physiology , Faculty of Medicine, Atatürk University , Erzurum , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gül
authors.affiliation: f Department of Chemistry , Faculty of Sciences, Atatürk University , Erzurum , Turkey , and.|g Department of Zoology , College of Science, King Saud University , Riyadh , Saudi Arabia.
authors.forename: İlhami
authors.initials: İ
authors.lastname: Gülçin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D044950:Flavanones / Q000494:pharmacology* / Q000627:therapeutic use*; D006614:Hindlimb / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D044950:Flavanones; D020011:Protective Agents; C005274:naringin
keywords: Antioxidant enzymes; Naringin; ischemia/reperfusion injury; reactive oxygen species; skeletal muscle