title: MUM-1 and bcl-2 Positive Primary Diffuse Large B Cell Non-Hodgkin's Lymphoma of the Colon.
abstract: Primary diffuse large B cell lymphoma (DLBCL) presents as a nodal and extranodal disease. The most common extranodal site is the gastrointestinal tract (GI), with the stomach most frequently involved, followed by the small bowel. Primary DLBCL of the large bowel accounts for 0.2%-1.2% of all colonic tumors. We present two patients who underwent radical resections of right colonic tumors. They were diagnosed with primary colonic DLBCL following histological and immunohistochemical testing of the excised tissues, and were determined as being in stage IIE of the disease. The tumors expressed CD20 markers. Both received multi-agent chemotherapy with combined immunotherapy and remain in complete remission at 4 and 5 years.
authors.affiliation: University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Jurisić
authors.affiliation: Medical Center, Valjevo, Serbia.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Plećić
authors.affiliation: Medical Faculty University, Belgrade, Serbia.
authors.forename: Natasa
authors.initials: N
authors.lastname: Colović
authors.affiliation: Laboratory Beolab, Resavska 60, Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Čemerikić-Martinović
authors.affiliation: Medical Faculty University, Belgrade, Serbia.
authors.forename: Marko
authors.initials: M
authors.lastname: Janković
authors.affiliation: Medical Faculty University, Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Čolović
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged