title: Spanish consensus for the management of patients with anaplastic cell thyroid carcinoma.
abstract: Anaplastic thyroid cancer (ATC) is the most aggressive solid tumor and almost uniformly lethal in humans. The Boards of the Thyroid Cancer Group of the Spanish Society of Endocrinology and Nutrition and the Grupo Español de Enfermedades Huérfanas e Infrecuentes of the Spanish Society of Oncology requested that an independent task force draft a more comprehensive consensus statement regarding ATC. All relevant literature was reviewed, including serial PubMed searches together with additional articles. This is the first, comprehensive Spanish consensus statement for ATC and includes the characteristics, diagnosis, initial evaluation, treatment goals, recommendations and modalities for locoregional and advanced disease, palliative care options, surveillance, and long-term monitoring. Newer systemic therapies are being investigated, but more effective combinations are needed to improve patient outcomes. Though more aggressive radiotherapy has reduced locoregional recurrences, median overall survival has not improved in more than 50 years.
authors.affiliation: Medical Oncology Service, Hospital Universitario Central de Asturias, Avenida de Roma sn, 33011, Oviedo, Spain. palucaji@hotmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Jiménez-Fonseca
authors.affiliation: CIBERDEM, Endocrinology and Nutrition Service, Hospital Universitario de Bellvitge, Barcelona, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Gómez Saez
authors.affiliation: Endocrinology and Nutrition Service, Hospital Universitario de Cruces, Vizcaya, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Santamaria Sandi
authors.affiliation: Medical Oncology Service, Hospital Universitario de la Vall d'Hebron, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Capdevila
authors.affiliation: Endocrinology and Nutrition Service, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Navarro Gonzalez
authors.affiliation: Endocrinology and Nutrition Service, Hospital Universitario de la Vall d'Hebron, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Zafon Llopis
authors.affiliation: Medical Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Ramón Y Cajal Asensio
authors.affiliation: Endocrinology and Nutrition Service, Hospital Universitario de Móstoles, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Riesco-Eizaguirre
authors.affiliation: Medical Oncology Service, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Grande
authors.affiliation: Endocrinology and Nutrition Service, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Galofré
mesh_terms: D000465:Algorithms; D003131:Combined Modality Therapy; D032921:Consensus; D006801:Humans; D013030:Spain; D065646:Thyroid Carcinoma, Anaplastic / Q000628:therapy*; D013964:Thyroid Neoplasms / Q000628:therapy*
keywords: Anaplastic thyroid carcinoma; Distant metastases; Genetic abnormalities; Poorly differentiated thyroid carcinoma