title: Associations between the FAS -670 A/G, -1377 G/A, and FASL -844 T/C polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether the FAS, and FASL polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE).
  
  
  METHODS
  A meta-analysis was conducted on the associations between the FAS -670 A/G, FAS -1377 G/A, and FASL -844 T/C polymorphisms and SLE.
  
  
  RESULTS
  A total of eleven articles met the study inclusion criteria. Meta-analysis indicated an association between SLE and the FAS -670 A/G polymorphism in the dominant model (OR=0.629, 95% CI=0.409-0.967, p=0.035). Stratification by ethnicity indicated an association between the FAS -670 GG+GA genotype and SLE in Asian populations (OR=0.464, 95% CI=0.218-0.988, p=0.046). Meta-analysis indicated an association between SLE and the FAS -1377 AA+AG genotype (OR=0.712, 95% CI=0.528 - 0.961, p=0.027), and an association between SLE and the FASL +844 C allele was found (OR=1.377, 95% CI=1.162 - 1.633, p=2.3x10(-4)). Meta-analyses using the recessive model or homozygote contrast showed the same pattern as the meta-analysis of the FASL +844 C allele, that is, a significant association with SLE.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the FAS -670 A/G, FAS -1377 G/A, and FASL -844 T/C polymorphisms are associated with susceptibility to SLE.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. lyhcgh@korea.ac.kr.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
mesh_terms: D053222:Fas Ligand Protein / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D019014:fas Receptor / Q000235:genetics*
chemical_list: C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D005819:Genetic Markers; D019014:fas Receptor