title: Outcome Disparities in Caucasian and Non-Caucasian Patients With Myeloproliferative Neoplasms.
abstract: BACKGROUND
  The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are characterized by an increased risk of thrombotic and hemorrhagic complications. Large retrospective studies have demonstrated racial disparities in MPN outcomes and attributed this to differences in access to health care. Utilizing a single institution experience, we report outcomes in patients with polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis in relation to ethno-racial background.
  
  
  METHODS
  A total of 127 Caucasian (56%) and non-Caucasian (44%) adult patients with MPNs consecutively treated at the University of Illinois between 1990 and 2012 were examined in this retrospective study. Relationships between ethno-racial background and vascular complications, and disease transformation were evaluated using multivariate logistic regression models.
  
  
  RESULTS
  Non-Caucasian PV patients had an increased risk of vascular complications including cardiovascular thrombosis and hemorrhagic events, while Caucasian patients with PV and ET had a higher risk of progression to myelofibrosis. In a Cox proportional hazard regression analysis, Caucasian race emerged as an independent prognostic factor protective against cardiovascular thrombosis in PV and ET patients (hazard ratio, 0.2; 95% confidence interval, 0.03-0.9; P = .04) while age > 60 years and prior thrombosis were significant risk factors in univariate analysis. Non-Caucasian race was also a significant risk factor in univariate analysis of hemorrhagic complications of PV and ET, and this was largely driven by African American ethnicity.
  
  
  CONCLUSIONS
  This study shows for the first time that race can influence clinical outcomes in myeloproliferative neoplasms. Our findings highlight the need for greater representation of non-Caucasian patients in studies investigating vascular risk factors in MPNs.
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL. Electronic address: irumkhan@uic.edu.
authors.forename: Irum
authors.initials: I
authors.lastname: Khan
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Ardaman
authors.initials: A
authors.lastname: Shergill
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Santosh L
authors.initials: SL
authors.lastname: Saraf
authors.affiliation: Design and Analysis Core, University of Illinois Cancer Center, Chicago, IL.
authors.forename: Yi-Fan
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Pritesh R
authors.initials: PR
authors.lastname: Patel
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: John G
authors.initials: JG
authors.lastname: Quigley
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: David
authors.initials: D
authors.lastname: Peace
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Victor R
authors.initials: VR
authors.lastname: Gordeuk
authors.affiliation: Division of Hematology/Oncology/Pathology, The Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Ronald
authors.initials: R
authors.lastname: Hoffman
authors.affiliation: Division of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Damiano
authors.initials: D
authors.lastname: Rondelli
mesh_terms: D000328:Adult; D005006:Ethnicity; D005260:Female; D006801:Humans; D007087:Illinois / Q000453:epidemiology / Q000208:ethnology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D044465:White People
keywords: Essential thrombocythemia; Hemorrhage; Polycythemia vera; Racial; Thrombosis