title: Differential pulse voltammetric determination of acyclovir in pharmaceutical preparations using a pencil graphite electrode.
abstract: In this study, a new selective and sensitive voltammetric procedure for determination of acyclovir (ACV) was proposed using a disposable electrode, pencil graphite electrode (PGE). Cyclic and differential pulse voltammograms of ACV were recorded in Britton-Robinson buffer solution containing 0.10 M KCl with pH of 4.0 at PGE. The PGE displayed a very good electrochemical behavior with significant enhancement of the peak current compared to a glassy carbon electrode (GCE). Under experimental conditions, the PGE had a linear response range from 1.0 μM to 100.0 μM ACV with a detection limit of 0.3 μM (based on 3 Sb). Relative standard deviations of 4.8 and 3.6% were obtained for five successive determinations of 10.0 and 50.0 μM ACV, respectively, which indicate acceptable repeatability. This voltammetric method was successfully applied to the direct determination of ACV in real pharmaceutical samples. The effect of various interfering compounds on the ACV peak current was studied.
authors.affiliation: Çanakkale Onsekiz Mart University, Biga Vocational School, Biga 17200, Çanakkale, Turkey. Electronic address: didemgiray79@hotmail.com.
authors.forename: Didem Giray
authors.initials: DG
authors.lastname: Dilgin
authors.affiliation: Çanakkale Onsekiz Mart University, Faculty of Science and Art, Chemistry Department, Analytical Research Laboratory, 17020, Çanakkale, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Karakaya
mesh_terms: D000212:Acyclovir / Q000032:analysis*; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D013059:Spectrum Analysis, Raman
chemical_list: D002244:Carbon; D006108:Graphite; D000212:Acyclovir
keywords: Acyclovir; Differential pulse voltammetry; Pencil graphite electrode