title: [The efficacy of intravenous lacosamide in psychiatric hospital].
abstract: OBJECTIVE
  To evaluate the efficacy and tolerability of intravenous lacosamide (vimpat) in inpatients with frequent partial-onset seizures and affective and cognitive disorders.
  
  
  METHODS
  Fifteen patients were enrolled including 14 patients diagnosed with «organic personality disorder associated with epilepsy» (cryptogenic or symptomatic epilepsy with frequent partial-onset and/or secondary-generalized seizures (serial seizures in some cases) and 1 patient with a preliminary diagnosis of «organic schizophrenia-like disorder», which was changed for «organic personality disorder associated with epilepsy» after examination. Patients were treated with 2--3 antiepileptic drugs (AEDs), but no one of them received earlier lacosamide. Lacosamide was used intravenously in drops in the dose of 200 or 400 mg daily during 5 days.
  
  
  CONCLUSIONS
  In 4 patients with marked personality disorders, the frequency of seizures decreased by 75%, no seizures were noted after 2--3 days of treatment in 11 patients. A positive effect of lacosamide on the affective sphere and quality-of-life was observed in 11 (73.4%) patients with epilepsy. Mild and moderate adverse effects were found only in 2 patients. It has been concluded that lacosamide demonstrates the high efficacy in patients with frequent drug-resistant seizures.
authors.affiliation: State Budgetary Healthcare Institution 'Specialized Clinical Psychiatric Hospital #1', Krasnodar.
authors.forename: I N
authors.initials: IN
authors.lastname: Vakula
authors.affiliation: State Budgetary Healthcare Institution 'Specialized Clinical Psychiatric Hospital #1', Krasnodar.
authors.forename: E O
authors.initials: EO
authors.lastname: Bojko
authors.affiliation: State Budgetary Healthcare Institution 'Specialized Clinical Psychiatric Hospital #1', Krasnodar.
authors.forename: U A
authors.initials: UA
authors.lastname: Vorona
authors.affiliation: State Budgetary Healthcare Institution 'Specialized Clinical Psychiatric Hospital #1', Krasnodar.
authors.forename: J A
authors.initials: JA
authors.lastname: Storozhuk
authors.affiliation: State Budgetary Healthcare Institution 'Specialized Clinical Psychiatric Hospital #1', Krasnodar.
authors.forename: E U
authors.initials: EU
authors.lastname: Nikiforova
authors.affiliation: State Budgetary Healthcare Institution 'Specialized Clinical Psychiatric Hospital #1', Krasnodar.
authors.forename: D I
authors.initials: DI
authors.lastname: Nikiforova
authors.affiliation: State Budgetary Healthcare Institution 'Specialized Clinical Psychiatric Hospital #1', Krasnodar.
authors.forename: T I
authors.initials: TI
authors.lastname: Glazunova
mesh_terms: D000081:Acetamides / Q000008:administration & dosage*; D061605:Administration, Intravenous; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage*; D004828:Epilepsies, Partial / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006778:Hospitals, Psychiatric; D006801:Humans; D000078334:Lacosamide; D008297:Male; D008875:Middle Aged; D010554:Personality Disorders / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide