title: The effect of aloe vera on ischemia--Reperfusion injury of sciatic nerve in rats.
abstract: OBJECTIVE
  Aloe vera is compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of aloe vera treatment in rats with experimental sciatic nerve ischemia/reperfusion injury.
  
  
  METHODS
  Twenty-eight male Wistar Albino rats were divided equally into 4 groups. Groups; Control group (no surgical procedure or medication), sciatic nerve ischemia/reperfusion group, sciatic nerve ischemia/reperfusion+aloe vera group and sciatic nerve ischemia/reperfusion+methylprednisolone group. Ischemia was performed by clamping the infrarenal abdominal aorta. 24 hours after ischemia, all animals were sacrificed. Sciatic nerve tissues were also examined histopathologically and biochemically.
  
  
  RESULTS
  Ischemic fiber degeneration significantly decreased in the pre-treated with aloe vera and treated with methylprednisolone groups, especially in the pre-treated with aloe vera group, compared to the sciatic nerve ischemia/reperfusion group (p<0.05). A significant decrease in MDA, an increase in NRF1 level and SOD activity were observed in the groups which obtained from the AV and MP groups when compared to the sciatic nerve ischemia/reperfusion group. When all results were analysed it was seen that the aloe vera group was not statistically different compared to the MP group (p>0.05).
  
  
  CONCLUSIONS
  Aloe vera is effective neuroprotective against sciatic nerve ischemia/reperfusion injury via antioxidant and anti-inflammatory properties. Also aloe vera was found to be as effective as MP.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Guven
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. Electronic address: uhg31@hotmail.com.
authors.forename: Umut Hatay
authors.initials: UH
authors.lastname: Gölge
authors.affiliation: Department of Histology & Embryology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Aslan
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Muserref Hilal
authors.initials: MH
authors.lastname: Sehitoglu
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Adem Bozkurt
authors.initials: AB
authors.lastname: Aras
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Tarik
authors.initials: T
authors.lastname: Akman
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Cosar
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009186:Myelin Sheath / Q000187:drug effects / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism; D051266:Nuclear Respiratory Factor 1 / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*; D012583:Schwann Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D051266:Nuclear Respiratory Factor 1; D010936:Plant Extracts; D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Aloe; Ischemia; Rats; Reperfusion injury; Sciatic nerve