title: Semicircular Canal Fibrosis as a Biomarker for Lateral Semicircular Canal Function Loss.
abstract: OBJECTIVE
  Radiological abnormalities at the level of the semicircular canals are frequently observed without known correlation to a pathologic condition or function. They include narrowing or sclerosis on computed tomography (CT) and narrowing or signal loss on T2-weighted magnetic resonance imaging (MRI). Our hypothesis was that these radiological abnormalities at the level of the semicircular canals reflect an aspecific but advanced stage of vestibular decay.
  
  
  METHODS
  Retrospective study in 35 consecutive patients with bilateral profound deafness eligible for cochlear implantation. Electronystagmography, CT, and MRI were performed as part of evaluation for cochlear implant candidacy.
  
  
  RESULTS
  In our population, 31.4% had a bilateral lateral semicircular canal function loss, while 11.4% had a unilateral lateral semicircular canal function loss. CT-scan abnormalities did not correlate to lateral semicircular canal function loss at a statistically significant level. However, abnormalities observed on MRI correlated significantly with ipsilateral lateral semicircular canal function loss. This statistically significant difference was present not only if abnormalities were observed in at least one of the semicircular canals but also if we studied the posterior, superior, and lateral semicircular canals separately.
  
  
  CONCLUSIONS
  Semicircular canal abnormalities on T2-weighted MRI (including narrowing and/or signal loss in one or more semicircular canals) are correlated to lateral semicircular canal function loss.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Van Rompaey
authors.affiliation: Department of Radiology, Antwerp University Hospital , Edegem , Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: De Belder
authors.affiliation: Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Department of Radiology, Antwerp University Hospital, Edegem, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Parizel
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Van de Heyning
keywords: cochlear implantation; computed tomography; magnetic resonance imaging; semicircular canals; vestibular function tests