title: Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones.
abstract: Phosphonium salt-activated, Pd-catalyzed Suzuki-Miyaura and Sonogashira cross-coupling reactions of cyclic 1,3-diones in the synthesis of β-substituted cyclic enones are described. These transformations exhibit good isolated yield and high generality with respect to both substrates and coupling partners. Extension of the substrate scope to cyclic 1,3-dione equivalents, such as 2-cyanocyclohexanone (4), is also briefly examined.
authors.affiliation: Cardiovascular and Metabolism Research, Janssen Research and Development, LLC , Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States.
authors.forename: Shyh-Ming
authors.initials: SM
authors.lastname: Yang
authors.affiliation: Cardiovascular and Metabolism Research, Janssen Research and Development, LLC , Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States.
authors.forename: Gee-Hong
authors.initials: GH
authors.lastname: Kuo
authors.affiliation: Cardiovascular and Metabolism Research, Janssen Research and Development, LLC , Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Gaul
authors.affiliation: Cardiovascular and Metabolism Research, Janssen Research and Development, LLC , Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States.
authors.forename: William V
authors.initials: WV
authors.lastname: Murray