title: Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
abstract: Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression.
authors.affiliation: Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: FuiBoon
authors.initials: F
authors.lastname: Kai
authors.affiliation: Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Hanane
authors.initials: H
authors.lastname: Laklai
authors.affiliation: Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Valerie.Weaver@ucsf.edu.
authors.forename: Valerie M
authors.initials: VM
authors.lastname: Weaver
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002465:Cell Movement; D004194:Disease; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness / Q000473:pathology*; D000069261:Podosomes / Q000473:pathology
keywords: cancer; cardiovascular disease; extracellular matrix stiffness; fibrosis; invasion; migration