title: [Cutaneous and mucosal manifestations associated with cocaine use].
abstract: Complications due to cocaine are a public health problem. The typical cutaneous disease is leukocytoclastic vasculitis and/or thrombotic vasculopathy affecting mainly the ears. No intense systemic involvement is usually present, but there may be several cutaneous, mucosal and systemic manifestations. Other findings associated as arthralgia, neutropaenia or agranulocytosis, low titer positive antinuclear antibodies, antiphospholipid antibody positivity and neutrophil cytoplasmic antibodies against multiple antigens help the diagnosis. This disease requires a clinical suspicion with a clinical history, a complete physical examination and a broad differential diagnosis for an early and correct diagnosis. The course is usually self-limited. In most cases the only treatment is to discontinue the use of cocaine associated with symptomatic treatment, no proven benefit of systemic corticosteroids.
authors.affiliation: Servicio de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, España. Electronic address: adrian_imber88@hotmail.com.
authors.forename: Adrián
authors.initials: A
authors.lastname: Imbernón-Moya
authors.affiliation: Servicio de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Chico
authors.affiliation: Servicio de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Aguilar-Martínez
mesh_terms: D019970:Cocaine-Related Disorders / Q000150:complications*; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy
keywords: Anticuerpos anticitoplasma de neutrófilos; Antineutrophil cytoplasmic antibodies; Cocaine; Cocaína; Levamisol; Levamisole; Thrombosis; Trombosis; Vasculitis