title: Probiotics and prebiotics in Crohn's disease therapies.
abstract: Therapeutic manipulation of gut microbiota has proven valuable in the management of ulcerative colitis and pouchitis. Despite some similarities among the various inflammatory bowel conditions, the probiotics investigated thus far seem to confer little benefit in Crohn's disease. In this review, we aim to bring together the evidence available on the clinical effect of probiotics and prebioltics in Crohn's disease patients, and to clarify the place of probiotic treatment in current Crohn's therapeutic regimens.
authors.affiliation: Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, University of Tel Aviv, Israel. Electronic address: levl@clalit.org.il.
authors.forename: Lev
authors.initials: L
authors.lastname: Lichtenstein
authors.affiliation: Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, University of Tel Aviv, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Avni-Biron
authors.affiliation: Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, University of Tel Aviv, Israel.
authors.forename: Ofer
authors.initials: O
authors.lastname: Ben-Bassat
mesh_terms: D003093:Colitis, Ulcerative / Q000628:therapy; D003424:Crohn Disease / Q000382:microbiology / Q000628:therapy*; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D056692:Prebiotics / Q000382:microbiology*; D019936:Probiotics / Q000627:therapeutic use*
chemical_list: D056692:Prebiotics
keywords: Bifidobacterium; Crohn's disease; Inflammatory bowel disease; Lactobacillus; Prebiotics; Probiotics; Sacchromyces boullardi; Synbiotics; VSL#3