title: The diagnostic value of soluble urokinase plasminogen activator receptor compared with C-reactive protein and procalcitonin in children with febrile neutropenia.
abstract: The aim of the present study was to determine the diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) in pediatric patients with febrile neutropenia. A prospective case-control study was performed. Patients included 29 children with febrile neutropenia (FN) and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on the day of admission and on the 4th to 7th days of the hospital stay. The median (minimum-maximum) serum levels of suPAR obtained on the first day of the admission were 2.08 (0.93-9.42) and 2.22 (1.08-5.13) ng/mL for the FN group and the control group, respectively. The median serum levels of suPAR in the FN and control groups were not significantly different (P = .053). The mean serum suPAR level was significantly higher in nonsurvivors than in survivors in the FN group (P < .05). In the FN group, the area under the receiver operating characteristics curve (AUCROC) for suPAR was 0.546, but no optimum cutoff value, sensitivity, specificity, negative predictive value (NPV), or positive predictive value (PPV) was obtained. We conclude that suPAR is not useful as a diagnostic biomarker in children with febrile neutropenia; however, persistent high serum suPAR level may predict mortality in FN in children.
authors.affiliation: a Division of Pediatric Infectious Diseasesm, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Melis
authors.initials: M
authors.lastname: Sirinoglu
authors.affiliation: a Division of Pediatric Infectious Diseasesm, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Soysal
authors.affiliation: a Division of Pediatric Infectious Diseasesm, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Karaaslan
authors.affiliation: a Division of Pediatric Infectious Diseasesm, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Kepenekli Kadayifci
authors.affiliation: b Department of Anesthesiology and Reanimation , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Cinel
authors.affiliation: c Division of Hematology and Oncology, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Koç
authors.affiliation: c Division of Hematology and Oncology, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Gülnur
authors.initials: G
authors.lastname: Tokuç
authors.affiliation: d Department of Biochemistry , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yaman
authors.affiliation: d Department of Biochemistry , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Goncagül
authors.initials: G
authors.lastname: Haklar
authors.affiliation: d Department of Biochemistry , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Önder
authors.initials: Ö
authors.lastname: Şirikçi
authors.affiliation: e Division of Pediatric Endocrinology, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Turan
authors.affiliation: f Department of Microbiology , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Gülşen
authors.initials: G
authors.lastname: Altınkanat Gelmez
authors.affiliation: f Department of Microbiology , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Güner
authors.initials: G
authors.lastname: Söyletir
authors.affiliation: a Division of Pediatric Infectious Diseasesm, Department of Pediatrics , Marmara University School of Medicine , Istanbul , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Bakır
mesh_terms: D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D064147:Febrile Neutropenia / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*
chemical_list: D055293:Receptors, Urokinase Plasminogen Activator; D002116:Calcitonin; D002097:C-Reactive Protein
keywords: Children; febril neutropenia; soluble urokinase plasminogen activator receptor