title: Low magnesium is not a significant predictor of hard events in acute myocardial infarction.
abstract: BACKGROUND
  Although magnesium (Mg) has recognized cardioprotective properties and hypomagnesemia is common in patients with acute myocardial infarction (AMI), data regarding the role of Mg as prognostic factor for adverse events are scarce, as well as there are conflicting results on the use of Mg as adjuvant therapy in AMI.
  
  
  OBJECTIVE
  To evaluate the role of Mg as predictor for hard events (HE, all cause death, and nonfatal myocardial infarction) in AMI patients.
  
  
  METHODS
  We studied 406 AMI patients (306 males, age: 67 ± 12 years, mean ± SD). Patient data were collected from the Institute electronic databank which saves demographic, clinical, instrumental, therapeutical and follow-up data of all patients admitted to our Coronary Unit.
  
  
  RESULTS
  During a mean follow-up period of 21 ± 18 months, the combined endpoint accounted for 63 HE, 44 (11%) deaths (35 cardiac deaths), 19 (5%) nonfatal MI. The multiple regression model identified glycemia as the only independent determinant of Mg in AMI pts. (T value = - 2.8, standard coefficient = - 0.15, p < 0.01). The Kaplan-Meier survival estimates failed to show a significantly worst outcome in patients presenting low Mg (< 0.783 mmol/L, 25th percentile). Aging (> 67 years-50th percentile), and ejection fraction (< 40%) remained as prognostic factors for HE in the adjusted Cox multivariate proportional hazard model (HR = 2.8, 95% CI = 1.6-5, p < 0.001; HR = 3.2, 95% CI = 1.9-5.3 p < 0.001, respectively).
  
  
  CONCLUSIONS
  The present findings do not support a significant role of low Mg as predictor for HE in AMI.
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Vassalle
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Battaglia
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vannucci
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy.
authors.forename: Kyriazoula
authors.initials: K
authors.lastname: Chatzianagnostou
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Landi
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Arvia
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Carpeggiani
keywords: Acute myocardial infarction; Hard event; Magnesium; Prognosis