title: Therapeutic hypothermia in adult patients receiving extracorporeal life support: early results of a randomized controlled study.
abstract: Cardiac arrest with cerebral ischaemia frequently leads to severe neurological impairment. Extracorporeal life support (ECLS) has emerged as a valuable adjunct in resuscitation of cardiac arrest. Despite ECLS, the incidence of permanent neurological injury remains high. We hypothesize that patients receiving ECLS for cardiac arrest treated with therapeutic hypothermia at 34 °C have lower neurological complication rates compared to standard ECLS therapy at normothermia. Early results of this randomized study suggest that therapeutic hypothermia is safe in adult patients receiving ECLS, with similar complication rates as ECLS without hypothermia. Further studies are warranted to measure the efficacy of this therapy.
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, 169609, ᅟ, Singapore. philip.pang.y.k@nhcs.com.sg.
authors.forename: Philip Y K
authors.initials: PY
authors.lastname: Pang
authors.affiliation: Cardiothoracic Intensive Care Unit, National Heart Centre Singapore, ᅟ, Singapore.
authors.forename: Gillian H L
authors.initials: GH
authors.lastname: Wee
authors.affiliation: Perfusion Unit, National Heart Centre Singapore, ᅟ, Singapore.
authors.forename: Anne E E
authors.initials: AE
authors.lastname: Hoo
authors.affiliation: Cardiothoracic Intensive Care Unit, National Heart Centre Singapore, ᅟ, Singapore.
authors.forename: Ismail Mohamed Tahir
authors.initials: IM
authors.lastname: Sheriff
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, 169609, ᅟ, Singapore.
authors.forename: See Lim
authors.initials: SL
authors.lastname: Lim
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, 169609, ᅟ, Singapore.
authors.forename: Teing Ee
authors.initials: TE
authors.lastname: Tan
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, 169609, ᅟ, Singapore.
authors.forename: Yee Jim
authors.initials: YJ
authors.lastname: Loh
authors.affiliation: Mechanical Circulatory Support, Heart and Lung Transplant Unit, National Heart Centre Singapore, ᅟ, Singapore.
authors.forename: Ka Lee
authors.initials: KL
authors.lastname: Kerk
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, 169609, ᅟ, Singapore.
authors.forename: Yoong Kong
authors.initials: YK
authors.lastname: Sin
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, 169609, ᅟ, Singapore.|Mechanical Circulatory Support, Heart and Lung Transplant Unit, National Heart Centre Singapore, ᅟ, Singapore.
authors.forename: Chong Hee
authors.initials: CH
authors.lastname: Lim
mesh_terms: D000328:Adult; D016887:Cardiopulmonary Resuscitation; D002493:Central Nervous System Diseases / Q000209:etiology; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
keywords: Cardiac arrest; Extracorporeal life support; Therapeutic hypothermia