title: Peanut Allergy: New Developments and Clinical Implications.
abstract: Food allergies have increased in prevalence over the past 20 years, now becoming an important public health concern. Although there are no therapies currently available for routine clinical care, recent reports have indicated that immunotherapies targeting the mucosal immune system may be effective. Oral immunotherapy is conducted by administering small, increasing amounts of food allergen; it has shown promise for desensitizing individuals with peanut, egg, or milk allergies. Sublingual immunotherapy also desensitizes allergic patients to foods-two major studies have examined the effects of sublingual immunotherapy in subjects with peanut allergies. We review the complex nature of IgE-mediated food allergies and the therapies being evaluated in clinical trials. We focus on the diagnosis and management of food allergies and investigational therapies.
authors.affiliation: Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA. scommins@email.unc.edu.|Thurston Arthritis Research Center, Chapel Hill, NC, USA. scommins@email.unc.edu.|Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA. scommins@email.unc.edu.|Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina, 3300 Thurston Building, CB 7280, Chapel Hill, NC, 27599-7280, USA. scommins@email.unc.edu.
authors.forename: Scott P
authors.initials: SP
authors.lastname: Commins
authors.affiliation: Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.|Thurston Arthritis Research Center, Chapel Hill, NC, USA.|Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Edwin H
authors.initials: EH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Orgel
authors.affiliation: Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Mike
authors.initials: M
authors.lastname: Kulis
mesh_terms: D000485:Allergens / Q000276:immunology; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D010367:Arachis / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007167:Immunotherapy; D021183:Peanut Hypersensitivity / Q000276:immunology*
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Anaphylaxis; Food allergy; IgE; Peanut allergy