title: Biomimetic synthesis of needle-like fluorescent calcium phosphate/carbon dot hybrid composites for cell labeling and copper ion detection.
abstract: Herein, we report a biomimetic method to synthesize needle-like calcium phosphate (CaP) with dimensions of ∼130 nm length and ∼30 nm width using carbon dots (CDs) and sodium carboxymethylcellulose as dual templates. In addition to acting as the template, the CDs enable the CaP/CDs hybrid composites to emit blue fluorescence under UV excitation. Moreover, the prepared CaP/CDs exhibited a negligible cytotoxicity towards HeLa cells. The potential of these CaP/CDs as a fluorescent probe for cell labeling was tested. In addition, it was demonstrated that the CaP/CDs were capable of selective detection of copper ions in drinking water.
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. xuem@ccmu.edu.cn.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. xuem@ccmu.edu.cn and China Rehabilitation Research Center, Beijing 100069, China.
authors.forename: Shousi
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. xuem@ccmu.edu.cn and Beijing Laboratory for Biomedical Detection Technology and Instrument, Beijing 100069, China.
authors.forename: Pingxiang
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. xuem@ccmu.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. xuem@ccmu.edu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. xuem@ccmu.edu.cn and Beijing Laboratory for Biomedical Detection Technology and Instrument, Beijing 100069, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Chemical Biology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China. weigu@ccmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. xuem@ccmu.edu.cn and Beijing Laboratory for Biomedical Detection Technology and Instrument, Beijing 100069, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xue
mesh_terms: D032701:Biomimetics; D002130:Calcium Phosphates; D002244:Carbon; D003300:Copper / Q000302:isolation & purification*; D060766:Drinking Water; D005456:Fluorescent Dyes; D006367:HeLa Cells; D006801:Humans; D045663:Quantum Dots; D013050:Spectrometry, Fluorescence
chemical_list: D002130:Calcium Phosphates; D060766:Drinking Water; D005456:Fluorescent Dyes; D002244:Carbon; D003300:Copper