title: Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology.
abstract: Clear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, microRNAs and recently identified long noncoding RNAs in the development and progression of ccRCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with ccRCCs. With the developed high-throughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of ccRCC.
authors.affiliation: 1 Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, 2 Department of Urology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Tianying
authors.initials: T
authors.lastname: Xing
authors.affiliation: 1 Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, 2 Department of Urology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: He
keywords: DNA methylation; clear cell renal cell carcinoma (ccRCC); histone modification; long noncoding RNA; microRNA