title: Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.
abstract: The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as core components of the machinery that drives cell cycle progression are well established. Increasing evidence indicates that mammalian cyclins and CDKs also carry out important functions in other cellular processes, such as transcription, DNA damage repair, control of cell death, differentiation, the immune response and metabolism. Some of these non-canonical functions are performed by cyclins or CDKs, independently of their respective cell cycle partners, suggesting that there was a substantial divergence in the functions of these proteins during evolution.
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Per
authors.initials: P
authors.lastname: Hydbring
authors.affiliation: Spanish National Cancer Research Centre (CNIO), E-28029 Madrid, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: Malumbres
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Piotr
authors.initials: P
authors.lastname: Sicinski
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D016213:Cyclins / Q000502:physiology*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006801:Humans; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D016213:Cyclins; D018844:Cyclin-Dependent Kinases