title: Prevalence of inflammatory bowel disease among patients with primary sclerosing cholangitis in Iran.
abstract: OBJECTIVE
  In Iran, the epidemiology of primary sclerosing cholangitis (PSC) and its association with inflammatory bowel disease (IBD) have not been studied thoroughly. This study investigates the epidemiology and prevalence of IBD among patients with PSC.
  
  
  METHODS
  A retrospective study of 154 patients with PSC was conducted. The demographic and clinical data were collected, and the variables were analysed in the following two patient groups: patients with both PSC and IBD, and patients with PSC and without IBD.
  
  
  RESULTS
  A total of 154 patients with a mean age of 40.3years (range 20-81years) were included, of whom 57 (37%) were female and 97 (63%) male. Ninety-six patients (62.3%) were diagnosed with IBD, 92 (59.7%) with ulcerative colitis, and four (2.6%) with Crohn's disease. In this study, elevated alkaline phosphatase levels were found in 90.8% of patients. The intra-hepatic duct (IHD) and extrahepatic duct (EHD) were involved in 70.5% of patients, isolated intrahepatic bile duct in 24.4%, and isolated extrahepatic duct in 3.8%. Small-duct PSC (normal results of imaging and PSC proved by histology of liver biopsy) was observed only in 1.3% of patients.
  
  
  CONCLUSIONS
  PSC has become increasingly diagnosed in Iran. This is possibly because of better diagnostics and the increasing prevalence of IBD in this country. For diagnosing PSC and identifying the presence of IHD strictures, the results of both magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) showed good interobserver agreement, but the ERCP results could be used to evaluate the presence and severity of EHD strictures.
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hadizadeh
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Seyed H
authors.initials: SH
authors.lastname: Abedi
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Habib
authors.initials: H
authors.lastname: Malekpour
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Radinnia
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Sayena
authors.initials: S
authors.lastname: Jabbehdari
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Padashi
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Zali
authors.affiliation: Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran. Electronic address: ahmaliver@yahoo.com.
authors.forename: Amir H
authors.initials: AH
authors.lastname: Mohammad Alizadeh
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D017734:Bile Ducts, Extrahepatic; D001653:Bile Ducts, Intrahepatic; D015209:Cholangitis, Sclerosing / Q000453:epidemiology*; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D003424:Crohn Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000469:Alkaline Phosphatase
keywords: Crohn’s disease; Inflammatory bowel disease; Primary sclerosing cholangitis; Ulcerative colitis