title: Is resveratrol therapeutic when used to treat allergic rhinitisinitis in rats?
abstract: OBJECTIVE
  Resveratrol has anti-infective, anti-inflammatory and antioxidant activities. The purpose of this study was to determine the effect of resveratrol in a rat experimental model of allergic rhinitis (AR).
  
  
  METHODS
  Wistar albino rats were divided into three groups: control (n=7), AR with no treatment (AR+NoTr, n=7) and AR with resveratrol treatment (AR+Res, n=7). For AR+Res, AR was induced and resveratrol given on days 21-28. On day 28, the total blood IgE levels were measured. Allergic symptoms (sneezing, nose-rubbing, eye lacrimation and nasal congestion) were scored on a 0-3 point scale, and histopathological changes in the nasal mucosa were evaluated.
  
  
  RESULTS
  Allergic symptom score of AR+NoTr was higher than the other two groups and the score of AR+Res was higher than the control group. Histopathologically, neither ciliary loss nor chondrocyte hypertrophy differed among the three groups; however, vascular congestion, inflammatory and plasma cell numbers, eosinophil and mast cell infiltration and goblet cell numbers were higher and mast cell infiltration was more prominent in AR+NoTr than in AR+Res and control. AR+Res and control did not differ significantly in any histological parameter. In AR+NoTr, nasal mucosa exhibited ciliary loss, squamous epithelial metaplasia, inflammatory cell infiltration, vascular congestion of the lamina propria and goblet cell epithelial metaplasia. In AR+Res, goblet cell metaplasia was focal or absent and infiltration of the lamina propria by inflammatory cells, eosinophils, and plasma cells was reduced relative to AR+NoTr.
  
  
  CONCLUSIONS
  Allergic symptoms and tissue reactions were reduced by resveratrol treatment in rats with experimentally-induced AR.
authors.affiliation: . email@email.com.
authors.forename: Kazım
authors.initials: K
authors.lastname: Bozdemir
authors.forename: Ethem
authors.initials: E
authors.lastname: Şahin
authors.forename: Niyazi
authors.initials: N
authors.lastname: Altintoprak
authors.forename: Nuray B
authors.initials: NB
authors.lastname: Muluk
authors.forename: Betül P
authors.initials: BP
authors.lastname: Cengiz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Acar
authors.forename: Cemal
authors.initials: C
authors.lastname: Cingi
mesh_terms: D000818:Animals; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol