title: [Research progress of the mechanisms underlying cadmium-induced carcinogenesis].
abstract: Since cadmium is an indirect genotoxic carcinogen, epigenetic modifications could be one of the major mechanisms underlying cadmium-induced carcinogenesis. It has been proposed that epigenetic alterations might be associated with cadmium-induced carcinogenesis, such as disruptions of DNA methylation, histone modifications, and microRNA expression profile, which would result in abnormal expression of carcinogenesis-related genes and/or imbalance of signal transduction pathways. Other mechanisms of cadmium-induced carcinogenesis consist of disruption of gene regulation and signaling pathways, repression of DNA repair, suppression of apoptosis, induction of oxidative stress and autophagy. Here, we reviewed the research of both epigenetic and non-epigenetic mechanisms underlying cadmium-induced carcinogenesis.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: C L
authors.initials: CL
authors.lastname: Xiao
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: Tu
authors.forename: Y J
authors.initials: YJ
authors.lastname: Xia
authors.forename: K M
authors.initials: KM
authors.lastname: Tian
authors.forename: X
authors.initials: X
authors.lastname: Zhou
mesh_terms: D017209:Apoptosis; D002104:Cadmium / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity*; D063646:Carcinogenesis / Q000139:chemically induced*; D002273:Carcinogens; D004249:DNA Damage / Q000187:drug effects*; D019175:DNA Methylation; D004260:DNA Repair / Q000187:drug effects*; D044127:Epigenesis, Genetic; D006801:Humans; D035683:MicroRNAs; D018384:Oxidative Stress / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D002273:Carcinogens; D035683:MicroRNAs; D002104:Cadmium