title: Vitamin D Supplementation Appears to Increase Plasma Aβ40 in Vitamin D Insufficient Older Adults: A Pilot Randomized Controlled Trial.
abstract: Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, +14.9 ± 12.0 and +12.8 ± 12.8 pg/mL (p = 0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was +18.3 ± 33.6 and -3.2 ± 44.5 pg/mL for vitamin (n = 4) and placebo (n = 4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Miller
authors.forename: Corrie M
authors.initials: CM
authors.lastname: Whisner
authors.forename: Carol S
authors.initials: CS
authors.lastname: Johnston
mesh_terms: D000367:Age Factors; D016229:Amyloid beta-Peptides / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002112:Calcifediol / Q000008:administration & dosage* / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000097:blood*; D010865:Pilot Projects; D016896:Treatment Outcome; D014808:Vitamin D Deficiency / Q000097:blood* / Q000178:diet therapy* / Q000523:psychology
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D002112:Calcifediol
keywords: Alzheimer’s disease; P-glycoprotein; amyloid-β; plasma Aβ; vitamin D