title: Surfactant Replacement Therapy Beyond Respiratory Distress Syndrome in Neonates.
abstract: BACKGROUND
  Surfactant replacement therapy is an established modality of treatment in preterm neonates with respiratory distress syndrome. In addition, there are various neonatal respiratory disorders which are characterized by surfactant deficiency in which surfactant therapy can be a feasible and safe option.
  
  
  OBJECTIVE
  To collate the literature on the use of surfactant replacement therapy in neonates beyond respiratory distress syndrome and examine the evidence and newer developments.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE, and EMBASE up to June 2015; and previous reviews, including cross-references, abstracts, and conference proceedings.
  
  
  RESULTS
  Evidence supports surfactant administration via bolus route in neonates with meconium aspiration syndrome, but additional robust evidence is required before its adoption in clinical practice. There is limited evidence to support surfactant therapy in neonates with pneumonia, pulmonary hemorrhage and bronchopulmonary dysplasia. Large multicenter randomized trials are needed to cement or refute the role of surfactant therapy in these disorders.
authors.affiliation: Department of Neonatology, King Edward Memorial Hospital, Parel, Mumbai, Maharashtra, India. Correspondence to: Dr Bonny Jasani, Department of Neonatology, King Edward Memorial Hospital for Women. Perth, WA 6008. docbonny_2000@yahoo.com.
authors.forename: Bonny
authors.initials: B
authors.lastname: Jasani
authors.forename: Nandkishor
authors.initials: N
authors.lastname: Kabra
authors.forename: Ruchi
authors.initials: R
authors.lastname: Nanavati
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy; D012140:Respiratory Tract Diseases / Q000188:drug therapy*
chemical_list: D011663:Pulmonary Surfactants