title: Ion Channels in the Eye: Involvement in Ocular Pathologies.
abstract: The eye is the sensory organ of vision. There, the retina transforms photons into electrical signals that are sent to higher brain areas to produce visual sensations. In the light path to the retina, different types of cells and tissues are involved in maintaining the transparency of avascular structures like the cornea or lens, while others, like the retinal pigment epithelium, have a critical role in the maintenance of photoreceptor function by regenerating the visual pigment. Here, we have reviewed the roles of different ion channels expressed in ocular tissues (cornea, conjunctiva and neurons innervating the ocular surface, lens, retina, retinal pigment epithelium, and the inflow and outflow systems of the aqueous humor) that are involved in ocular disease pathophysiologies and those whose deletion or pharmacological modulation leads to specific diseases of the eye. These include pathologies such as retinitis pigmentosa, macular degeneration, achromatopsia, glaucoma, cataracts, dry eye, or keratoconjunctivitis among others. Several disease-associated ion channels are potential targets for pharmacological intervention or other therapeutic approaches, thus highlighting the importance of these channels in ocular physiology and pathophysiology.
authors.affiliation: Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Giblin
authors.affiliation: Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Comes
authors.affiliation: Charite University Medicine, Berlin, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Strauss
authors.affiliation: Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address: xgasull@ub.edu.
authors.forename: Xavier
authors.initials: X
authors.lastname: Gasull
mesh_terms: D001082:Aqueous Humor / Q000378:metabolism; D003315:Cornea / Q000378:metabolism / Q000473:pathology; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000235:genetics* / Q000378:metabolism; D005123:Eye / Q000294:innervation / Q000378:metabolism* / Q000473:pathology; D005128:Eye Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007908:Lens, Crystalline / Q000294:innervation / Q000378:metabolism / Q000473:pathology; D009154:Mutation; D012160:Retina / Q000378:metabolism* / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000378:metabolism / Q000473:pathology
chemical_list: D054815:Cyclic Nucleotide-Gated Cation Channels
keywords: Cornea; Eye; Ion channel; Lens; Retina; Retinal pigment epithelium; Vision