title: The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer's Disease.
abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by memory loss and cognitive dysfunction. Aquaporin-4 (AQP4), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS). This protein plays an important role in water and ion homeostasis in the normal brain and in various brain pathological conditions. Emerging evidence suggests that AQP4 deficiency impairs learning and memory and that this may be related to the expression of glutamate transporter-1 (GLT-1). Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD. Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD. Here, we review the interaction of AQP4 and GLT-1 in astrocytes, which might play a pivotal role in the regulation of distinct cellular responses that involve neuroprotection against AD. The association of AQP4 and GLT-1 could greatly supplement previous research regarding neuroprotection against AD.
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian 116044, China; Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China.
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Lan
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian 116044, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zou
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian 116044, China.
authors.forename: Jian-Jiao
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian 116044, China; Liaoning Engineering Technology Centre of Target-Based Nature Products for Prevention and Treatment of Ageing-Related Neurodegeneration, Dalian 116044, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian 116044, China.
authors.forename: Shao
authors.initials: S
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D051401:Aquaporin 4 / Q000235:genetics / Q000378:metabolism*; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D027342:Excitatory Amino Acid Transporter 2 / Q000235:genetics / Q000378:metabolism*; D006801:Humans
chemical_list: D051401:Aquaporin 4; D027342:Excitatory Amino Acid Transporter 2