title: Altered Expression of IFN-λ2 in Allergic Airway Disorders and Identification of Its Cell Origins.
abstract: This study investigated the expression levels of interferon- (IFN-) λ2 in peripheral blood and tissues. The results showed that the levels of IFN-λ2 were elevated by 17.9% and 14.2% in the plasma of allergic rhinitis (AR) and combined rhinitis with asthma (AR + AS), which was positively correlated with the level of tryptase but negatively correlated with the level of IL-10. IFN-λ2 was predominately expressed in the CD16+ cells and CD14+ cells in healthy control subjects (HC) but upregulated only in CD8+ cells of AR and in eosinophils of asthma. It was observed that approximately 6.6% and 7.0% dispersed tonsil cells and 5.8% and 0.44% dispersed lung cells are IFN-λ2+ mast cells and macrophages. Moreover, tryptase and agonist peptides of PAR-2 induced enhanced IFN-λ2 mRNA expression in A549 cells. In conclusion, the elevated levels of IFN-λ2 in the plasma of AR and AR + AS indicate that IFN-λ2 is likely to contribute to the pathogenesis of allergic airway disorders. The potential origins of the elevated plasma IFN-λ2 include mast cells, macrophages, and epithelial cells in tissues, neutrophils, monocytes, CD8+ T cells, and eosinophils in peripheral blood. Development of IFN-λ2 related therapy may help to treat or prevent allergic airway disorders.
authors.affiliation: Department of ENT, Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Qiuli
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of ENT, Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Respiratory Medicine, The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of ENT, Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China.
authors.forename: Qijian
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China.
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China.
authors.forename: Chiyan
authors.initials: C
authors.lastname: Xu
authors.affiliation: Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China.
authors.forename: Lingfei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of ENT, Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Shaoheng
authors.initials: S
authors.lastname: He
authors.affiliation: Department of ENT, Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Huiyun
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002460:Cell Line; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000097:blood / Q000378:metabolism; D007378:Interleukins / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D065631:Rhinitis, Allergic / Q000097:blood / Q000378:metabolism; D055815:Young Adult; D000095022:Interferon Lambda
chemical_list: D016753:Interleukin-10; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C508609:IL10 protein, human