title: Fabrication of an electrochemical sensor based on spiropyran for sensitive and selective detection of fluoride ion.
abstract: In the past decades, numerous electrochemical sensors based on exogenous electroactive substance have been reported. Due to non-specific interaction between the redox mediator and the target, the instability caused by false signal may not be avoided. To address this issue, in this paper, a new electrochemical sensor based on spiropyran skeleton, namely SPOSi, was designed for specific electrochemical response to fluoride ions (F(-)). The breakage of Si-O induced by F(-) based on the specific nucleophilic substitution reaction between F(-) and silica would directly produce a hydroquinone structure for electrochemical signal generation. To improve the sensitivity, SPOSi probe was assembled on the single-walled carbon nanotubes (SWCNTs) modified glassy carbon electrode (GCE) through the π-π conjugating interaction. This electrode was successfully applied to monitor F(-) with a detection limit of 8.3 × 10(-8) M. Compared with the conventional F(-) ion selected electrode (ISE) which utilized noncovalent interaction, this method displays higher stability and a comparable sensitivity in the urine samples.
authors.affiliation: School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha, 410004, China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China; College of Chemical Science and Engineering South China University of Technology, Guangzhou, 510641, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Tao
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. Electronic address: yinhuili16@163.com.
authors.forename: Yinhui
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha, 410004, China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. Electronic address: yangrh@pku.edu.cn.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Yang
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D005459:Fluorides / Q000032:analysis*; D007211:Indoles / Q000737:chemistry*; D057230:Limit of Detection; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D007211:Indoles; D009574:Nitro Compounds; C088184:spiropyran; D005459:Fluorides
keywords: Electrochemical sensors; Fluoride ion; SWCNTs; Spiropyran