title: Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting.
abstract: Colloidal clusters of magnetic iron oxide nanocrystals (MIONs), particularly in the condensed pattern (co-CNCs), have emerged as new superstructures to improve further the performance of MIONs in applications pertaining to magnetic manipulation (drug delivery) and magnetic resonance imaging (MRI). Exploitation of the advantages they represent and their establishment in the area of nanomedicine demands a particular set of assets. The present work describes the development and evaluation of MION-based co-CNCs featuring for the first time such assets: High magnetization, as well as magnetic content and moment, high relaxivities (r2 = 400 and r2* = 905 s(-1) mMFe(-1)) and intrinsic loss power (2.3 nH m(2) kgFe(-1)) are combined with unprecedented colloidal stability and structural integrity, stealth and drug-loading properties. The reported nanoconstructs are endowed with additional important features such as cost-effective synthesis and storage, prolonged self-life and biocompatibility. It is finally showcased with in vivo multispectral optoacoustic tomography how these properties culminate in a system suitable for targeting breast cancer and for forceful in vivo manipulation with low magnetic field gradients.
authors.affiliation: Department of Materials Science, University of Patras, 26504 Rio, Greece.
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Sarigiannis
authors.affiliation: Department of Materials Science, University of Patras, 26504 Rio, Greece.
authors.forename: Αrgiris
authors.initials: Α
authors.lastname: Kolokithas-Ntoukas
authors.affiliation: Institute for Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universität München, D-85764 Neuherberg, Germany.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Beziere
authors.affiliation: Regional Centre of Advanced Technologies and Materials, Departments of Physical Chemistry and Experimental Physics, Faculty of Science, Palacky University, 783 71 Olomouc, Czech Republic.
authors.forename: Radek
authors.initials: R
authors.lastname: Zbořil
authors.affiliation: Department of Pharmacy, University of Patras, 26504 Rio, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Papadimitriou
authors.affiliation: Department of Pharmacy, University of Patras, 26504 Rio, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Avgoustakis
authors.affiliation: Department of Pharmacy, University of Patras, 26504 Rio, Greece.
authors.forename: Margarita
authors.initials: M
authors.lastname: Lamprou
authors.affiliation: Regional Centre of Advanced Technologies and Materials, Departments of Physical Chemistry and Experimental Physics, Faculty of Science, Palacky University, 783 71 Olomouc, Czech Republic.
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Medrikova
authors.affiliation: Department of Materials Science, University of Patras, 26504 Rio, Greece.
authors.forename: Elias
authors.initials: E
authors.lastname: Rousalis
authors.affiliation: Institute for Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universität München, D-85764 Neuherberg, Germany. Electronic address: v.ntziachristos@tum.de.
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
authors.affiliation: Department of Materials Science, University of Patras, 26504 Rio, Greece; Regional Centre of Advanced Technologies and Materials, Departments of Physical Chemistry and Experimental Physics, Faculty of Science, Palacky University, 783 71 Olomouc, Czech Republic. Electronic address: aristeidis.bakandritsos@upol.cz.
authors.forename: Aristides
authors.initials: A
authors.lastname: Bakandritsos
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D059346:Magnets / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000032:analysis / Q000737:chemistry*; D061088:Photoacoustic Techniques / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D000903:Antibiotics, Antineoplastic; D005290:Ferric Compounds; C000499:ferric oxide; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: Hybrid colloids; Hyperthermia; Magnetic targeting; Nanocrystal clusters; Optoacoustic imaging; Theranostics