title: Oxytocin in hypothalamic supraoptic nucleus is transferred to the caudate nucleus to influence pain modulation.
abstract: Oxytocin (OXT), which is synthesized and secreted in the hypothalamic supraoptic nucleus (SON), is the most important bioactive substance in SON regulating pain process. Our previous study has pointed that OXT in the caudate nucleus (CdN) plays a role in pain modulation. The communication was designed to investigate the source of OXT in the rat CdN during pain process using the methods of push-pull perfusion and radioimmunoassay. The results showed that (1) pain stimulation increased the OXT concentration in the CdN perfusion liquid; (2) SON cauterization inhibited the increase of OXT concentration in CdN perfusion liquid induced by the pain stimulation, which role in both sides of SON cauterization was stronger than that in one side of SON cauterization; and (3) SON microinjection of l-glutamate sodium, which excited the SON neurons, increased OXT concentration in the CdN perfusion liquid. The data suggested that OXT in the CdN was influenced by SON during pain process, i.e., OXT in the SON might be transferred to the CdN to influence pain modulation.
authors.affiliation: The Second Affiliated Hospital of Xinxiang Medical University (Henan Provincial Mental Hospital), Xinxiang, Henan 453002, China.
authors.forename: Yang-Juan
authors.initials: YJ
authors.lastname: Pan
authors.affiliation: Jiangsu Su Bei People's Hospital (Clinical College of Yangzhou University), Yangzhou, Jiangsu 225001, China.
authors.forename: Da-Xin
authors.initials: DX
authors.lastname: Wang
authors.affiliation: Jiangsu Su Bei People's Hospital (Clinical College of Yangzhou University), Yangzhou, Jiangsu 225001, China; Xinxiang Institute for New Medicine, Xinxiang, Henan 435003, China; Standard Technological Co., Ltd., Xinxiang, Henan 435003, China. Electronic address: bcd2009@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Xinxiang Institute for New Medicine, Xinxiang, Henan 435003, China.
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: He
authors.affiliation: Xinjiang Hongda Food & Beverage Co. Ltd., Xinjiang, Shanxi 043112, China.
authors.forename: Nai-Min
authors.initials: NM
authors.lastname: Xiao
authors.affiliation: Standard Technological Co., Ltd., Xinxiang, Henan 435003, China.
authors.forename: Rui-Qing
authors.initials: RQ
authors.lastname: Ma
authors.affiliation: The Second Affiliated Hospital of Xinxiang Medical University (Henan Provincial Mental Hospital), Xinxiang, Henan 453002, China.
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Wang
authors.affiliation: Department of Neurobiology, Second Military Medical University, Shanghai 200433, China.
authors.forename: Bao-Cheng
authors.initials: BC
authors.lastname: Lin
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D010121:Oxytocin / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013495:Supraoptic Nucleus / Q000378:metabolism*
chemical_list: D010121:Oxytocin
keywords: Caudate nucleus; Hypothalamic supraoptic nucleus; Oxytocin; Pain modulation; Rat