title: Cu(I)- or Ag(I)-Catalyzed Regio- and Stereocontrolled trans-Hydrofluorination of Ynamides.
abstract: With Et3N·3HF as the fluorinating reagent, a copper(I)- or silver(I)-catalyzed β/α-site-regiocontrolled trans-hydrofluorination of alkynamides has been achieved, affording the corresponding fluoro enamides in moderate to nearly quantitative yields with high regio- and stereoselectivity, respectively. The reaction proceeds under mild reaction conditions and exhibits good functional group tolerance. Further, the deuterium-labeling experiment confirmed the existence of the alkenylcopper intermediate.
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , Nanjing 211816, People' s Republic of China.
authors.forename: Guangke
authors.initials: G
authors.lastname: He
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , Nanjing 211816, People' s Republic of China.
authors.forename: Shineng
authors.initials: S
authors.lastname: Qiu
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , Nanjing 211816, People' s Republic of China.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , Nanjing 211816, People' s Republic of China.
authors.forename: Guohao
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , Nanjing 211816, People' s Republic of China.
authors.forename: Dongming
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , Nanjing 211816, People' s Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , Nanjing 211816, People' s Republic of China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zhu