title: Efficient synthesis of new 2,3-dihydrooxazole-spirooxindoles hybrids as antimicrobial agents.
abstract: Two series of new 2,3-dihydrooxazole-spirooxindole derivatives were efficiently synthesized starting from N'-(2-oxoindolin-3-ylidene) benzohydrazide/N'-(2-oxoindolin-3-ylidene)-2-phenoxyacetohydrazide using designed synthetic route. Newly synthesized 2,3-dihydrooxazole-spirooxindole derivatives were screened for their antibacterial and antifungal activity against different pathogenic strain of bacteria and fungi. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were determined for the test compounds as well as for reference standards. Compounds 4e, 4g, 7g have shown good antibacterial activity whereas compounds 4f, 7b, 7d have displayed better antifungal activity.
authors.affiliation: Department of Chemistry, University of Allahabad, Allahabad, UP 211002, India. Electronic address: drshailendratiwariau@gmail.com.
authors.forename: Shailendra
authors.initials: S
authors.lastname: Tiwari
authors.affiliation: Department of Chemistry, University of Allahabad, Allahabad, UP 211002, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Pathak
authors.affiliation: Department of Chemistry, Shiv Nadar University, NH-91 Dadri, GB Nagar, UP 201314, India.
authors.forename: Ram
authors.initials: R
authors.lastname: Sagar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D010080:Oxazoles; D013141:Spiro Compounds
keywords: 2,3-Dihydrooxazole-spirooxindole; Antimicrobial antibacterial activity; Antimicrobial antifungal activity; Hydrazide; Isatin; Schiff base; Spirooxindole