title: Cariprazine for the Treatment of Bipolar Disorder.
abstract: OBJECTIVE
  To review the data regarding a new antipsychotic, cariprazine.
  
  
  CONCLUSIONS
  Cariprazine is a dopamine D3, D2 partial agonist, with greater affinity to D3. It has been examined for schizophrenia, bipolar mania, bipolar depression, and unipolar depression. It has demonstrated efficacy in schizophrenia and mania, and has recently been approved by the U.S. Food and Drug Administration. However, it has a more inconsistent effect in depression, both unipolar and bipolar. Adverse effects include extrapyramidal symptoms, akathisia, and gastrointestinal distress.
  
  
  CONCLUSIONS
  Cariprazine will be a promising addition in the treatment of patients with acute mania and schizophrenia.
authors.affiliation: Lillian Jan Findlay, PhD, is Assistant Professor, and Coordinator, Psychiatric Mental Health Academic Program, School of Nursing, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Lillian Jan
authors.initials: LJ
authors.lastname: Findlay
authors.affiliation: Peggy L. El-Mallakh, PhD, is Assistant Professor, School of Nursing, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Peggy L
authors.initials: PL
authors.lastname: El-Mallakh
authors.affiliation: Rif S. El-Mallakh, MD, Director, Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA.
authors.forename: Rif S
authors.initials: RS
authors.lastname: El-Mallakh
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000188:drug therapy*; D018491:Dopamine Agonists / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D010879:Piperazines; C533287:cariprazine
keywords: Bipolar depression; bipolar disorder; cariprazine; dopamine D2 receptor; dopamine D3 receptor; mania