title: A Case of Severe Rectal Hemorrhage Possibly Caused by Radiation Recall after Administration of Gemcitabine.
abstract: Radiation recall is an acute inflammatory reaction that can be triggered when systemic agents are administered long time after radiotherapy. Because radiotherapy is now indicated for many types of cancer, care should be taken regarding possible toxic events relating to radiotherapy in combination with radio-sensitizing agents. Gemcitabine, one such anti-cancer agent, is widely used, especially for urologic cancers. We report an intriguing case of possible radiation recall in the rectum caused by gemcitabine administration 37 years after radiation therapy. From a review of the literature, it appears that there have been no reported cases of radiation recall in the rectum with such a long interval between radiation therapy and chemotherapy. Here, we describe the case and provide a literature review.
authors.affiliation: Department of Urology, Tachikawa Hospital, Tokyo, Japan.
authors.forename: Koshiro
authors.initials: K
authors.lastname: Nishimoto
authors.forename: Yushi
authors.initials: Y
authors.lastname: Akise
authors.forename: Masaharu
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Shoji
authors.initials: S
authors.lastname: Kutsuki
authors.forename: Subaru
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Uchida
mesh_terms: D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000628:therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D006801:Humans; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000009:adverse effects*; D011855:Radiodermatitis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D012007:Rectum / Q000098:blood supply / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000628:therapy; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D011838:Radiation-Sensitizing Agents; D003841:Deoxycytidine; D000093542:Gemcitabine