title: A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity.
abstract: A polymer network of intranuclear lamin filaments underlies the nuclear envelope and provides mechanical stability to the nucleus in metazoans. Recent work demonstrates that the expression of A-type lamins scales positively with the stiffness of the cellular environment, thereby coupling nuclear and extracellular mechanics. Using the spectrin-actin network at the erythrocyte plasma membrane as a model, we contemplate how the relative stiffness of the nuclear scaffold impinges on the growing number of interphase-specific nuclear envelope remodeling events, including recently discovered, nuclear envelope-specialized quality control mechanisms. We suggest that a stiffer lamina impedes these remodeling events, necessitating local lamina remodeling and/or concomitant scaling of the efficacy of membrane-remodeling machineries that act at the nuclear envelope.
authors.affiliation: Department of Cell Biology, Yale School of Medicine, New Haven, CT, United States. Electronic address: megan.king@yale.edu.
authors.forename: Megan C
authors.initials: MC
authors.lastname: King
authors.affiliation: Department of Cell Biology, Yale School of Medicine, New Haven, CT, United States. Electronic address: patrick.lusk@yale.edu.
authors.forename: C Patrick
authors.initials: CP
authors.lastname: Lusk
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D006801:Humans; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D009687:Nuclear Proteins