title: A semi-automated workflow solution for multimodal neuroimaging: application to patients with traumatic brain injury.
abstract: Traumatic brain injury (TBI) is a major cause of mortality and morbidity, placing a significant financial burden on the healthcare system worldwide. Non-invasive neuroimaging technologies have been playing a pivotal role in the study of TBI, providing important information for surgical planning and patient management. Advances in understanding the basic mechanisms and pathophysiology of the brain following TBI are hindered by a lack of reliable image analysis methods for accurate quantitative assessment of TBI-induced structural and pathophysiological changes seen on anatomical and functional images obtained from multiple imaging modalities. Conventional region-of-interest (ROI) analysis based on manual labeling of brain regions is time-consuming and the results could be inconsistent within and among investigators. In this study, we propose a workflow solution framework that combined the use of non-linear spatial normalization of structural brain images and template-based anatomical labeling to automate the ROI analysis process. The proposed workflow solution is applied to dynamic PET scanning with15O-water (0-10 min) and18F-FDDNP (0-6 min) for measuring cerebral blood flow in patients with TBI.
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: Koon-Pong
authors.initials: KP
authors.lastname: Wong
authors.affiliation: Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: Marvin
authors.initials: M
authors.lastname: Bergsneider
authors.affiliation: Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Glenn
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kepe
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Barrio
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA ; Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Hovda
authors.affiliation: Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA ; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Vespa
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA ; Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
authors.forename: Sung-Cheng
authors.initials: SC
authors.lastname: Huang
keywords: 15O-water; 18F-FDDNP; Cerebral blood flow (CBF); Magnetic resonance imaging (MRI); Positron emission tomography (PET); Spatial normalization; Traumatic brain injury (TBI)