title: Labdane Diterpenes from the Fruits of Sinopodophyllum emodi.
abstract: Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1-4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity.
authors.affiliation: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. sunyanjun2011@hactcm.edu.cn.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. sunyanjun2011@hactcm.edu.cn.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Sun
authors.affiliation: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. gaoxiaomei6266@126.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. gaoxiaomei6266@126.com.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Gao
authors.affiliation: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. zyl2013hnzy@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. zyl2013hnzy@163.com.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. wjmhnzz@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. wjmhnzz@163.com.
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Wang
authors.affiliation: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. wuya0723@126.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China. wuya0723@126.com.
authors.forename: Ya
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Pharmacy, China Medical University, Shenyang 110122, Liaoning, China. xiaowangyu21@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmacy, China Medical University, Shenyang 110122, Liaoning, China. taoliu0307@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
mesh_terms: D000969:Antinematodal Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D028141:Berberidaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure
chemical_list: D000969:Antinematodal Agents; D004224:Diterpenes
keywords: Sinopodophyllum emodi; cytotoxic activity; labdane diterpene