title: Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma.
abstract: Previous studies have found higher levels of serum malondialdehyde (MDA) in hepatocellular carcinoma (HCC) patients compared to healthy controls and higher MDA concentrations in tumoral tissue of HCC patients than in non-tumoral tissue. However, the association between pre-transplant serum levels of MDA and survival in HCC patients after liver transplantation (LT) has not been described, and the aim of the present study was to determine whether such an association exists. In this observational study we measured serum MDA levels in 127 patients before LT. We found higher pre-LT serum MDA levels in 15 non-surviving than in 112 surviving patients one year after LT (p = 0.02). Exact binary logistic regression analysis revealed that pre-LT serum levels of MDA over 3.37 nmol/mL were associated with mortality after one year of LT (Odds ratio = 5.38; 95% confidence interval (CI) = from 1.580 to infinite; p = 0.007) adjusting for age of the deceased donor. The main finding of our study was that there is an association between serum MDA levels before LT for HCC and 1-year survival after LT.
authors.affiliation: Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, Santa Cruz de Tenerife 38320, Spain. lorentemartin@msn.com.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lorente
authors.affiliation: Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. sergiotomasr@hotmail.com.
authors.forename: Sergio T
authors.initials: ST
authors.lastname: Rodriguez
authors.affiliation: Department of Surgery, Hospital Universitario Nuestra Señora de Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. sanzpereda@gmail.com.
authors.forename: Pablo
authors.initials: P
authors.lastname: Sanz
authors.affiliation: Department of Physiology, Faculty of Medicine, University of the La Laguna, Ofra, s/n, La Laguna, Santa Cruz de Tenerife 38320, Spain. pabreu@ull.es.
authors.forename: Pedro
authors.initials: P
authors.lastname: Abreu-González
authors.affiliation: Department of Digestive, Hospital Universitario Nuestra Señora de Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. ddiazbet@gmail.com.
authors.forename: Dácil
authors.initials: D
authors.lastname: Díaz
authors.affiliation: Department of Digestive, Hospital Universitario Nuestra Señora de Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. antoniamorenotenerife@gmail.com.
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Moreno
authors.affiliation: Department of Digestive, Hospital Universitario Nuestra Señora de Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. elisaajrob@yahoo.es.
authors.forename: Elisa
authors.initials: E
authors.lastname: Borja
authors.affiliation: Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. mar.martinvelasco@gmail.com.
authors.forename: María M
authors.initials: MM
authors.lastname: Martín
authors.affiliation: Research Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, Santa Cruz de Tenerife 38320, Spain. ajimenezsosa@gmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Jiménez
authors.affiliation: Department of Surgery, Hospital Universitario Nuestra Señora de Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. mbargom@yahoo.es.
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Barrera
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000628:therapy*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000097:blood / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve; D016896:Treatment Outcome
chemical_list: D008315:Malondialdehyde
keywords: MDA; hepatocellular carcinoma; liver transplantation; mortality; outcome