title: Takotsubo Cardiomyopathy in a 22-Year-Old Single-Ventricle Patient.
abstract: We report a highly unusual case of a 22-year-old woman with single-ventricle anatomy and a history of Fontan palliation who developed takotsubo cardiomyopathy. To our knowledge, takotsubo cardiomyopathy has not previously been described in a patient with single-ventricle anatomy, or more generally in any patient with congenital heart disease. The patient presented at our clinic for urgent examination after a 2-day history of chest pain that had begun upon the death of her dog. Invasive evaluation was refused by the patient; instead, she underwent electrocardiogram-gated coronary computed tomographic angiography, to rule out obstructive coronary disease. A physician who suspects takotsubo cardiomyopathy in a patient should look for new-onset chest pain and dyspnea coupled with these features: immediate onset of segmental akinesia in the midventricular or apical aspects of the heart, elevation of brain natriuretic peptide level 12 to 24 hours after onset of akinesia, elevation of troponin level 24 to 48 hours after onset, and disappearance of the segmental akinesia a few days after onset.
authors.forename: Gwendolyn Rose
authors.initials: GR
authors.lastname: Derk
authors.forename: Jamil
authors.initials: J
authors.lastname: Aboulhosn
authors.forename: Leigh C
authors.initials: LC
authors.lastname: Reardon
mesh_terms: D003937:Diagnosis, Differential; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006352:Heart Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D054549:Takotsubo Cardiomyopathy / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D016276:Ventricular Function / Q000502:physiology; D055815:Young Adult
keywords: Apical-ballooning syndrome; Fontan procedure; cardiomyopathies/diagnosis; coronary vasospasm/complications; female; heart disease, congenital; single ventricle; stress, psychological/complications; takotsubo cardiomyopathy/diagnosis/epidemiology/therapy; treatment outcome; ventricular dysfunction/etiology/radiography