title: Alcohol Consumption and Incident Dementia: Evidence from the Sydney Memory and Ageing Study.
abstract: Alcohol consumption is a potentially modifiable risk factor for dementia, but the literature is not completely consistent. This inconsistency may be partly due to an interaction with the apolipoprotein E (APOE) genotype, an established risk factor for Alzheimer's dementia. The aim of this study was to examine whether alcohol consumption is associated with incident dementia or decline in specific cognitive domains over 4 years, and if this effect is modified by APOEɛ4 status. Non-demented community dwelling older adults (70-90 years) from an ongoing longitudinal study were assessed for cognitive impairment in attention/processing speed, language, executive function, visuospatial ability, and memory. Incident dementia was diagnosed according to DSM-IV criteria. Compared to those who did not drink in the previous 12 months, neither low consumption (HR 0.64 95% CI 0.3-1.4) or risky consumption (HR 0.58 95% CI 0.2-1.5) was associated with incident dementia. Carriers of the APOEɛ4 allele were more likely to develop dementia, but there was no significant interaction with alcohol consumption.
authors.affiliation: Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Megan
authors.initials: M
authors.lastname: Heffernan
authors.affiliation: Centre for Health Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Mather
authors.affiliation: Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Amelia A
authors.initials: AA
authors.lastname: Assareh
authors.affiliation: Centre for Health Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.|Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Kochan
authors.affiliation: Centre for Health Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Simone
authors.initials: S
authors.lastname: Reppermund
authors.affiliation: Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: Draper
authors.affiliation: Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Julian N
authors.initials: JN
authors.lastname: Trollor
authors.affiliation: Centre for Health Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.|Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
authors.forename: Perminder
authors.initials: P
authors.lastname: Sachdev
authors.affiliation: Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.|Centre for Health Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000235:genetics; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D003863:Depression / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D009483:Neuropsychological Tests; D009517:New South Wales / Q000453:epidemiology; D016016:Proportional Hazards Models; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4
keywords: Alcohol; Alzheimer’s disease; cognitive decline; cognitive impairment; dementia