title: [Effects of resuscitation by different formulation on oxygen metabolism during shock stage of burn injury in swine].
abstract: OBJECTIVE
  To explore the effects of different fluid resuscitation regimens on oxygen metabolism during shock stage of burn injury in swine.
  
  
  METHODS
  Twelve Bama miniature swines were divided into crystal and colloid group (Group 1) and Parkland group (Group 2) according to the random number table. The swine models of burns shock were established. The fluid resuscitation was begun at post injury hour (PIH) 2 according to Chinese formulation or Parkland's formulation, respectively. The blood pressure, urine volume, heart rate, central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP) were recorded. The liquid volume was calculated at the first and second PIH 24. The changes in oxygen delivery (DO2), oxygen consumption (VO2), oxygen extraction (O2Ext) and D-lactate (D-LA) were determined before injury and at PIH 4, 8, 24, and 48. Statistical analyses were performed.
  
  
  RESULTS
  There were no statistical differences between the two groups in blood pressure, urine volume, heart rate, CVP, PCWP in every interval (all P>0.05). The resuscitation liquid volume in the two groups during the first and second PIH 24 conformed to the domestic consensus. The VO2 at PIH 8 was significantly higher than that of pre-burn in both groups [(190±29) vs (83±42) L·min(-1)·m(-2,) (149±33) vs (85±15) L·min(-1)·m(-2,) both P<0.05], and the VO2 at PIH 8 was significantly higher in Group 1 than that in Group 2 (P<0.05). The DO2 at PIH 24 in Group 1 was significantly lower than that in Group 2 [(686±72) vs (853±81) L·min(-1)·m(-2,) P<0.05]. There were no significant differences between the two groups in O2Ext at any time points (all P>0.05). The D-LA at PIH 8 was significantly higher in Group 1 than that in Group 2 [(53±4) vs (45±6) mmol/L, P<0.05].
  
  
  CONCLUSIONS
  There are no significant differences in the resuscitation effects of the crystal and colloid resuscitation regimen and Parkland's formulation on oxygen metabolism during shock stage of burn injury in swine.
authors.affiliation: Burns and Skin Repair Surgery, Third Affiliated Hospital, Wenzhou Medical University, Ruian 325200, China.
authors.forename: D Y
authors.initials: DY
authors.lastname: Wu
authors.forename: W X
authors.initials: WX
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: D J
authors.initials: DJ
authors.lastname: Xue
authors.forename: J J
authors.initials: JJ
authors.lastname: Zhou
authors.forename: X M
authors.initials: XM
authors.lastname: Lu
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002056:Burns / Q000628:therapy*; D002496:Central Venous Pressure; D005440:Fluid Therapy; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D011669:Pulmonary Wedge Pressure; D012151:Resuscitation / Q000379:methods*; D012769:Shock; D013552:Swine; D013556:Swine, Miniature
chemical_list: D010100:Oxygen