title: [Preterm ovarian hyperstimulation syndrome: a case report and literature review].
abstract: OBJECTIVE
  To discuss the clinical characteristics, pathogenesis, diagnosis and treatment of preterm ovarian hyperstimulation syndrome(POHS).
  
  
  METHODS
  The process of diagnosis and treatment of a test-tube female baby were summarized. She was deliveried at 32(+ 2) weeks of gestation, diagnosed with POHS, and born in the First Affiliated Hospital of Wenzhou Medical University(in 2015). Retrieval of related literature in PubMed database and Wanfang database was performed using the key words"ovarian hyperstimulation syndrome"and"preterm infants or newborns"from 1980 to 2015.
  
  
  RESULTS
  The patient developed labial hyperemia and edema, ectropion of vaginal mucosa and plica, swelling of the hypogastrium and upper legs at 41 days (38(+ 1) weeks post-conception). The child was continuously observed because diagnosis was not clear. The pelvic and abdominal ultrasonography examinations revealed a cyst in the right ovary and laboratory evaluation of the baby showed high concentrations of gonadotropin and estradiol at 49 days (39(+ 2) weeks post-conception), and thus the baby was diagnosed with POHS. With no special intervention measures, the baby became normal at 169 days (4 months post-conception). Six papers from foreign literature were retrieved and none from Chinese literature, which reported 12 cases of POHS. They all characterized prematurity, ovarian cyst/cysts, labial hyperemia and edema, swelling of the hypogastrium and upper leg, high serum gonadotropin and estradiol levels at 35 to 39 weeks post-conception, including 3 cases with breast enlargement, 1 case with vaginal bleeding and 1 case with ectropion of vaginal mucosa and plica. The treatments included in 1 case combined surgery with pharmacological intervention, in another case only pharmacological intervention, and in the others no interventional measures were taken but were only followed up. As for the results, the baby with the surgical treatment had recurrence, but the symptoms, ovarian cyst and hormone concentration of the other babies gradually became normal in 4-5 months.
  
  
  CONCLUSIONS
  POHS is a rare and self-limiting disease. The common clinical features of this disease are prematurity, ovarian cyst or cysts, labia hyperemia and edema, swelling in the hypogastrium and upper legs, high serum gonadotropin and estradiol levels at 35 to 39 weeks post-conception. It does not require treatment if there is no complication, but follow-up is necessary.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: C E
authors.initials: CE
authors.lastname: Chen
authors.forename: T W
authors.initials: TW
authors.lastname: Di
authors.forename: R H
authors.initials: RH
authors.lastname: Zhu
authors.forename: L L
authors.initials: LL
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Qian
authors.forename: Y Y
authors.initials: YY
authors.lastname: Sun
mesh_terms: D004958:Estradiol / Q000097:blood; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D010048:Ovarian Cysts / Q000000981:diagnostic imaging; D016471:Ovarian Hyperstimulation Syndrome / Q000175:diagnosis*; D014463:Ultrasonography
chemical_list: D006062:Gonadotropins; D004958:Estradiol