title: Reductive Hydrazination with Trichlorosilane: A Method for the Preparation of 1,1-Disubstituted Hydrazines.
abstract: A straightforward and facile method has been developed to prepare 1,1-disubstituted hydrazines via Lewis base promoted direct reductive hydrazination. Under the catalysis of hexamethylphosphoramide (HMPA) and N,N-dimethylacetamide (DMAc), respectively, various ketones and aldehydes could react with phenylhdrazines to prepare 1,1-disubstituted hydrazines with good to high yields.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 China.|Graduate School of Chinese Academy of Sciences , Beijing, 10049, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 China.|Graduate School of Chinese Academy of Sciences , Beijing, 10049, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Di
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 China.|Graduate School of Chinese Academy of Sciences , Beijing, 10049, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 China.|Graduate School of Chinese Academy of Sciences , Beijing, 10049, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 China.|Graduate School of Chinese Academy of Sciences , Beijing, 10049, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
mesh_terms: D000081:Acetamides / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000586:Amination; D002384:Catalysis; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D058115:Lewis Bases / Q000737:chemistry; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D000447:Aldehydes; D006834:Hydrazines; D007659:Ketones; D058115:Lewis Bases; D012821:Silanes; C013959:dimethylacetamide; C065893:trichlorosilane