title: [Value of desmopressin stimulation test and high dose dexamethasone suppression testin the etiologic diagnosis of ACTH dependent Cushing's syndrome].
abstract: OBJECTIVE
  To investigate the value of desmopressin (DDAVP) stimulation test and high dose dexamethasone suppression test (HDDST) in establishing the cause of ACTH dependent Cushing's syndrome.
  
  
  METHODS
  The clinical data of patients with ACTH dependent Cushing's syndrome at West China Hospital from January 1, 2010 to September 30, 2015 was analyzed. The sensitivity and specificity of DDAVP stimulation test, HDDST, and the diagnostic accordance rate when the two tests were combined, were evaluated based on the diagnostic gold standard.
  
  
  RESULTS
  A total of 85 patients with Cushing's disease and 10 patients with ectopic ACTH syndrome were included. The sensitivity and specificity of DDAVP stimulation test were 87% and 5/5, respectively, whereas those of HDDST were 79% and 8/10, respectively. The standard high dose dexamethasone suppression test showed a higher sensitivity than overnight 8 mg dexamethasone suppression test. When the two tests had consistent results, the diagnostic accordance rate was 100%.
  
  
  CONCLUSIONS
  DDAVP stimulation test and HDDST are both efficient modalities for the diagnosis of Cushing's Disease and ectopic ACTH syndrome. The accuracy of diagnosis can be further improved by combining the two tests.
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yerong
authors.initials: Y
authors.lastname: Yu
authors.forename: Huiwen
authors.initials: H
authors.lastname: Tan
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Li
authors.forename: Zhenmei
authors.initials: Z
authors.lastname: An
authors.forename: Yuping
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D002681:China; D003480:Cushing Syndrome / Q000175:diagnosis*; D003894:Deamino Arginine Vasopressin; D003907:Dexamethasone; D003937:Diagnosis, Differential; D006801:Humans; D012680:Sensitivity and Specificity
chemical_list: D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D003894:Deamino Arginine Vasopressin