title: Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system.
abstract: Local delivery of therapeutic agents into the brain has many advantages; however, the inability to predict, visualize and confirm the infusion into the intended target has been a major hurdle in its clinical development. Here, we describe the current workflow and application of the interventional MRI (iMRI) system for catheter placement and real time visualization of infusion. We have applied real time convection-enhanced delivery (CED) of therapeutic agents with iMRI across a number of different clinical trials settings in neuro-oncology and movement disorders. Ongoing developments and accumulating experience with the technique and technology of drug formulations, CED platforms, and iMRI systems will continue to make local therapeutic delivery into the brain more accurate, efficient, effective and safer.
authors.affiliation: a Department of Neurological Surgery , University of California, San Francisco , San Francisco , CA , USA.
authors.forename: Seunggu J
authors.initials: SJ
authors.lastname: Han
authors.affiliation: a Department of Neurological Surgery , University of California, San Francisco , San Francisco , CA , USA.
authors.forename: Krystof
authors.initials: K
authors.lastname: Bankiewicz
authors.affiliation: a Department of Neurological Surgery , University of California, San Francisco , San Francisco , CA , USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Butowski
authors.affiliation: a Department of Neurological Surgery , University of California, San Francisco , San Francisco , CA , USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Larson
authors.affiliation: a Department of Neurological Surgery , University of California, San Francisco , San Francisco , CA , USA.
authors.forename: Manish K
authors.initials: MK
authors.lastname: Aghi
mesh_terms: D002490:Central Nervous System / Q000187:drug effects*; D016503:Drug Delivery Systems; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional; D013997:Time Factors
keywords: Interventional MRI; catheter placement; convection enhanced delivery; drug delivery; real time