title: [Clinical experience of the use of memantal in patients with moderate and severe Alzheimer's disease].
abstract: OBJECTIVE
  To assess the efficacy and safety of memantal, a generic formulation of memantine, in patients with moderate and severe dementia due to Alzheimer's disease (AD).
  
  
  METHODS
  Thirty patients with moderate and severe AD, aged from 55 to 84 years, were examined. Memantal was used in the dose of 20 mg per day after the titration period. Duration of treatment was 3 months.
  
  
  RESULTS
  To the end of the study, there was a moderate positive effect as assessed by the CGI. During the treatment, cognitive functions and different forms of daily activity have improved. Significant positive changes in behavioral symptoms of dementia were noted. No adverse effects were observed during the treatment.
  
  
  CONCLUSIONS
  The results of the analysis revealed the clinical efficacy and safety of memantal in treatment of AD.
authors.affiliation: Mental Health Research Centre, Moscow.
authors.forename: S I
authors.initials: SI
authors.lastname: Gavrilova
authors.affiliation: Mental Health Research Centre, Moscow.
authors.forename: I V
authors.initials: IV
authors.lastname: Kolykhalov
authors.affiliation: Mental Health Research Centre, Moscow.
authors.forename: A S
authors.initials: AS
authors.lastname: Kulik
authors.affiliation: Mental Health Research Centre, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Ponomareva
authors.affiliation: Mental Health Research Centre, Moscow.
authors.forename: N D
authors.initials: ND
authors.lastname: Selezneva
authors.affiliation: Mental Health Research Centre, Moscow.
authors.forename: Ya B
authors.initials: YB
authors.lastname: Fedorova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D003071:Cognition / Q000187:drug effects; D016568:Drugs, Generic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008559:Memantine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D016568:Drugs, Generic; D008559:Memantine