title: Multiplexing and Beyond in Biobehavioral Research.
abstract: In contrast to traditional singleplex assays that provide values for only a single analyte in a single biological sample, multiplex assays are a time- and resource-efficient high-throughput approach that provides the opportunity to determine numerous analytes within a single- and small-sample volume. In this editorial on an article by Dorn et al. in this issue of Psychosomatic Medicine, we provide a brief description of the advantages and challenges related to multiplex assays. Although the use of multiplexing as a tool has been relatively limited in biobehavioral research, more recent studies are taking advantage of this technology to obtain deeper insight into regulatory patterns in health and disease states. Multiplex approaches range from several targets to global target profiling that importantly enable unbiased biomarker and pathway discovery.
authors.affiliation: From the Department of Family Medicine and Public Health, Center of Excellence for Research and Training in Integrative Health (Mills, Peterson), and Department of Psychiatry (Mills), University of California, San Diego, La Jolla, California.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mills
authors.forename: Christine T
authors.initials: CT
authors.lastname: Peterson
mesh_terms: D035841:Behavioral Research / Q000379:methods*; D035843:Biomedical Research / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans