title: Does Core Length Taken per cc of Prostate Volume in Prostate Biopsy Affect the Diagnosis of Prostate Cancer?
abstract: The aim of this study was to determine the minimal core length to be taken per cc of prostate volume for an effective prostate biopsy.
  
  
  
  A retrospective analysis was performed on the records of 379 patients who underwent a first prostate biopsy with 12 to 16 cores under transrectal ultrasound guidance between September 2012 and April 2015. For each patient, the core length per cc of the prostate and the percentage of sampled prostate volume were calculated, and these values were compared between the patients with and without prostate cancer.
  
  
  
  A total of 348 patients were included in the study. Cancer was determined in 26.4% of patients. The mean core length taken per cc of prostate and the percentage of sampled prostate volume were determined to be 3.40 ± 0.15 mm/cc (0.26%; range, 0.08-0.63 cc) in patients with cancer and 2.75 ± 0.08 mm/cc (0.20%; range, 0.04-0.66 cc) in patients without cancer (P = .000 and P = .000), respectively. Core length taken per cc of prostate of > 3.31 mm/cc was found to be related to an increase in the rates of prostate cancer diagnosis (odds ratio, 2.84; 95% confidence interval, 1.68-4.78). The rate of cancer determination for core length taken per cc of prostate of < 3.31 mm/cc was 19.9% and of > 3.31 mm/cc, 41.1%.
  
  
  
  Core length taken per cc of prostate and the percentage of sampled prostate volume are important morphometric parameters in the determination of prostate cancer. The results of study suggest a core length per cc of the prostate of > 3.31 mm/cc as a cutoff value for quality assurance.
authors.affiliation: Department of Urology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey. Electronic address: hasandeliktas@mynet.com.
authors.forename: Hasan
authors.initials: H
authors.lastname: Deliktas
authors.affiliation: Department of Urology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Sahin
authors.affiliation: Department of Urology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cetinkaya
authors.affiliation: Department of Pathology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Yelda
authors.initials: Y
authors.lastname: Dere
authors.affiliation: Department of Urology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Erdogan
authors.affiliation: Department of Biostatistics, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Baldemir
mesh_terms: D000368:Aged; D062005:Biopsy, Large-Core Needle; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D047368:Tumor Burden; D014463:Ultrasonography
keywords: Core length; Per cc of the prostate; Prostate biopsy; Prostate cancer; Sampled prostate volume