title: The preparation of metal-organic frameworks and their biomedical application.
abstract: The development of a safe and targetable drug carrier is a major challenge. An efficient delivery system should protect cargo from degradation and cleanup, and control of drug release in the target site. Metal-organic frameworks (MOFs), consisting of metal ions and a variety of organic ligands, have been applied for drug delivery due to their distinct structure. In this review, we summarized the synthesis strategies of MOFs, especially emphasizing the methods of pore creation in frameworks, which were based on recent literatures. Subsequently, the controlled size, biocompatibility, drug releasing performances, and imaging of MOFs were discussed, which would pave the road for the application in drug-delivery systems.
authors.affiliation: School of Medicine and Nursing, Chengdu University, Chengdu, People's Republic of China; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: School of Medicine and Nursing, Chengdu University, Chengdu, People's Republic of China.
authors.forename: Tian
authors.initials: T
authors.lastname: Yu
authors.affiliation: School of Medicine and Nursing, Chengdu University, Chengdu, People's Republic of China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D009942:Organometallic Compounds
keywords: biocompatibility; drug releasing performances; imaging; metal-organic frameworks; pore creation; the controlled size