title: Local resection for duodenal gastrointestinal stromal tumors.
abstract: BACKGROUND
  Duodenal gastrointestinal tumors (GIST) present infrequently, and surgical resection with negative margins remains the mainstay of therapy; however, given the lack of lymphatic and submucosal spread and anatomic location near the bile duct and pancreas, the optimal approach for resection is unknown. Options include local resection (LR), segmental resection, and pancreaticoduodenectomy (PD).
  
  
  METHODS
  All cases of gastrointestinal stromal tumors originating from the duodenum from 2000 to 2015 were identified from administrative databases. Clinical and pathologic information was abstracted from the medical record and compared between patients who received LR vs PD. The chi-square with Fisher's exact test was used to detect differences between groups.
  
  
  RESULTS
  Fifteen patients met the inclusion criteria, of which 7 had an LR and 8 had a PD. The second portion of the duodenum was the most common origin of GIST in the PD group, whereas the third portion was most common in the LR group. Patients who underwent LR tended to be younger, but there was no difference in tumor size, mitotic rate, margin positivity, readmission rate, or recurrence. PD was associated with more complications, higher blood loss, and longer length of stay.
  
  
  CONCLUSIONS
  Local resection is a reasonable option for resection of duodenal GIST and should be routinely considered if technically feasible.
authors.affiliation: Section of General, Thoracic, and Vascular Surgery, Virginia Mason Medical Center, 1100 Ninth Av., Seattle, WA 98101, USA.
authors.forename: Angelena
authors.initials: A
authors.lastname: Crown
authors.affiliation: Section of General, Thoracic, and Vascular Surgery, Virginia Mason Medical Center, 1100 Ninth Av., Seattle, WA 98101, USA.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Biehl
authors.affiliation: Section of General, Thoracic, and Vascular Surgery, Virginia Mason Medical Center, 1100 Ninth Av., Seattle, WA 98101, USA. Electronic address: flavio.rocha@virginiamason.org.
authors.forename: Flavio G
authors.initials: FG
authors.lastname: Rocha
mesh_terms: D000328:Adult; D000368:Aged; D003082:Colectomy / Q000379:methods* / Q000401:mortality; D016208:Databases, Factual; D018572:Disease-Free Survival; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D004384:Duodenoscopy / Q000379:methods; D004386:Duodenum / Q000601:surgery; D019160:Endosonography / Q000379:methods; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D016577:Pancreaticoduodenectomy / Q000379:methods / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Duodenum; Gastrointestinal tumor; Local resection