title: [ASSOCIATION OF POLYMORPHIC MARKERS IN GENES OF INNATE IMMUNITY IN PATIENTS WITH PERIODONTITIS AND INFLAMMATORY DISEASES OF UPPER RESPIRATORY TRACT].
abstract: OBJECTIVE
  Search of association of polymorphisms in DEFB1, IL-10, TNF-α and TLR2 genes with development of chronic generalized periodontitis in representatives of Ural region (Caucasian race).
  
  
  METHODS
  142 patients, that were split into 3 groups, took part in the study: a group of patients with periodontitis, a group with frequent inflammatory disease of upper respiratory tract and a comparison group--healthy donors. A study of polymorphic markers was carried out: DEFB1 (-44G/C), DEFB1 (-20A/G), IL-10 (-1082.A/G), TNF-α (-308 G/A), Arg753Gln and Arg677Trp using PCR in real time mode.
  
  
  RESULTS
  Association of infectious pathology ofupper respiratory tract and development of periodontitis diseases with markers in DEFB1 (-44G/C) and Arg753Gln and Arg677Trp genes was determined. Significant differences in distribution of genotypes and alleles of genes IL-10 and TNF-α in the group of patients with periodontitis and comparison group were not detected.
  
  
  CONCLUSIONS
  DEFB1 (-44G/C) polymorphism can be examined as a marker of periodontitis development risk.
authors.forename: N G
authors.initials: NG
authors.lastname: Sarkisyan
authors.forename: L V
authors.initials: LV
authors.lastname: Gankovskaya
authors.forename: I A
authors.initials: IA
authors.lastname: Tuzankina
authors.forename: O A
authors.initials: OA
authors.lastname: Svitich
authors.forename: G I
authors.initials: GI
authors.lastname: Ron
authors.forename: V N
authors.initials: VN
authors.lastname: Shershnev
authors.forename: O N
authors.initials: ON
authors.lastname: Kolyadina
authors.forename: M A
authors.initials: MA
authors.lastname: Dolgikh
mesh_terms: D000328:Adult; D000483:Alleles; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D060888:Real-Time Polymerase Chain Reaction; D012141:Respiratory Tract Infections / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D051195:Toll-Like Receptor 2 / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology; D023083:beta-Defensins / Q000235:genetics* / Q000276:immunology
chemical_list: D015415:Biomarkers; C406407:DEFB1 protein, human; C508609:IL10 protein, human; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D014409:Tumor Necrosis Factor-alpha; D023083:beta-Defensins; D016753:Interleukin-10