title: Orthogonal strategy for the synthesis of dual-functionalised β(3)-peptide based hydrogels.
abstract: We have described a new class of hydrogelator based on helical β(3)-peptides carrying a bioactive payload. The β(3)-peptides self-assemble in aqueous solution to form a nanofibrous mesh resulting in a stable hydrogel. The simple design provides the versatility for attaching different functional payloads to the β(3)-peptide scaffold to develop new materials.
authors.affiliation: Monash Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Clayton Vic, 3800, Australia. mark.delborgo@monash.edu mibel.aguilar@monash.edu.
authors.forename: Ketav
authors.initials: K
authors.lastname: Kulkarni
authors.forename: Sepideh
authors.initials: S
authors.lastname: Motamed
authors.forename: Nathan
authors.initials: N
authors.lastname: Habila
authors.forename: Patrick
authors.initials: P
authors.lastname: Perlmutter
authors.forename: John S
authors.initials: JS
authors.lastname: Forsythe
authors.forename: Marie-Isabel
authors.initials: MI
authors.lastname: Aguilar
authors.forename: Mark P
authors.initials: MP
authors.lastname: Del Borgo
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D004548:Elasticity; D020100:Hydrogels / Q000138:chemical synthesis* / Q000494:pharmacology; D055666:Lipopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D012212:Rheology; D014783:Viscosity
chemical_list: D020100:Hydrogels; D055666:Lipopeptides; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid