title: Porokeratoma: A Possible Association with Human Papillomavirus Infection.
abstract: Porokeratoma is a rare, relatively newly described and still unclear entity. Here, we describe the case of a 52-year-old male patient who presented with four well-defined, verrucous and hyperkeratotic lesions. Microscopically, one of the lesions showed acanthopapillomatosis overlying compact orthokeratosis. Prominent broad and confluent cornoid lamellae were present, with no granular layer and some dyskeratotic keratinocytes. PCR sequencing and in situ hybridization revealed the presence of human papillomavirus (HPV) type 16 in the lesion. The association of porokeratoma and HPV infection has not previously been reported.
authors.affiliation: Department of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Patricia
authors.initials: P
authors.lastname: Caseiro Silverio
authors.affiliation: Dermatopathology Unit, Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Xuan-Cuong
authors.initials: XC
authors.lastname: Pham
authors.affiliation: Dermatopathology Unit, Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Gürkan
authors.initials: G
authors.lastname: Kaya
keywords: Cornoid lamellae; Human papillomavirus; Porokeratoma; Porokeratosis