title: Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk.
abstract: The pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-12 A (IL12A) genes, but the existing findings are inconsistent. Our aim is to investigate the associations of two single-nucleotide polymorphisms (SNPs) (rs2816316 in RGS1 and rs17810546 in IL12A) with CD risk using meta-analysis. We searched PubMed and Web of Science on RGS1 rs2816316 and IL12A rs17810546 with CD risk. Odds ratio (OR) and 95% confidence interval (CI) of each SNP were estimated. All statistical analyses were performed on Stata 12.0. A total of seven studies were retrieved and analyzed. The available data indicated the minor allele C of rs2816316 was negatively associated with CD (C vs. A: OR = 0.77, 95% CI = 0.74-0.80), and a positive association was found for the minor allele G of rs17810546 (G vs. A: OR = 1.37, 95% CI = 1.31-1.43). The co-dominant model of genotype effect confirmed the significant associations between RGS1 rs2816316/IL12A rs17810546 and CD. No evidence of publication bias was observed. Our meta-analysis supports the associations of RGS1 and IL12A with CD and strongly calls for further studies to better understand the roles of RGS1 and IL12A in the pathogenesis of CD.
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. guo301@aliyun.com.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. manwang29610@163.com.
authors.forename: Man
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Stomatology of the First Affiliated Hospital of Jinan University, Guangzhou 510632, China. CFDfengdi@163.com.
authors.forename: Feng-Di
authors.initials: FD
authors.lastname: Cao
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. jnuhwh1987@163.com.
authors.forename: Wei-Huang
authors.initials: WH
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. kwstljh@163.com.
authors.forename: Di
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. yexingguang1989@sina.com.
authors.forename: Xing-Guang
authors.initials: XG
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. meiling800569@sina.cn.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Ou
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. zhangronna@gmail.com.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. candy2006520@163.com.
authors.forename: Bao-Huan
authors.initials: BH
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. liuyang199101@126.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Parasitology, School of Medicine, Jinan University, Guangzhou 510632, China. guangyangphd@gmail.com.|Key Laboratory of Environmental Exposure and Health in Guangzhou, Jinan University, Guangzhou 510632, China. guangyangphd@gmail.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China. jcxphd@gmail.com.|Key Laboratory of Environmental Exposure and Health in Guangzhou, Jinan University, Guangzhou 510632, China. jcxphd@gmail.com.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Jing
mesh_terms: D002446:Celiac Disease / Q000235:genetics* / Q000473:pathology; D016208:Databases, Factual; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D020710:RGS Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D020710:RGS Proteins; C080831:RGS1 protein, human; D018664:Interleukin-12
keywords: IL12A; RGS1; celiac disease; meta-analysis; polymorphism