title: Effects of adrenaline on circulatory dynamics and cardiac function in rats administered chlorpromazine.
abstract: We aimed to elucidate changes in circulatory dynamics and cardiac function during concomitant use of chlorpromazine (CPZ) and adrenaline (AD). An arterial line and left intraventricular pressure-volume measurement catheter were inserted in rats. CPZ 10 mg/kg was administered to the left great adductor muscle, followed by normal saline (NS) or AD 50 μg/kg through the tongue 20 min later. End-diastolic volume (Ved), end-systolic pressure (Pes), stroke volume (SV), stroke work (SW), end-systolic volume elastance (Ees), systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR) were measured. Following AD administration, Vedsignificantly decreased at 2-4 and 10 min than that in control rats; Pessignificantly decreased at 1 min; Eessignificantly increased from 2 to 10 min; SV did not change significantly, and SW significantly reduced at 1 and 2 min; SBP and DBP were lower at 1-3 min than in the control; and PR increased at 10 min. These findings suggest that when AD-containing local anesthetics are administered during dental treatment of patients taking CPZ, there is a risk of a temporary drop in blood pressure. However, the blood pressure is recovered a few minutes later by the increase in afterload and the myocardial contractile force.
authors.affiliation: Department of Dental Anesthesiology, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20, Fujimi, Chiyoda-ku, Tokyo, 102-8159, Japan.
authors.forename: Arisa
authors.initials: A
authors.lastname: Sakai
authors.affiliation: Department of Dental Anesthesiology, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20, Fujimi, Chiyoda-ku, Tokyo, 102-8159, Japan. katsu.sunada@nifty.com.
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Sunada
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage* / Q000494:pharmacology*; D004837:Epinephrine / Q000008:administration & dosage* / Q000494:pharmacology*; D006334:Heart Function Tests; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002746:Chlorpromazine; D004837:Epinephrine
keywords: Adrenaline; Cardiac function; Chlorpromazine; Circulatory dynamics; Pressure–volume catheter