title: [TRPM7 and tumor].
abstract: The transient receptor potential (TRP) family is a superfamily of cation channels located on the cell membrane. Transient receptor potential melastatin (TRPM) 7, a member of the TRPM subgroup of TRP channels, and was the most representative biofunctional membrane protein. It conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. It is capable of phosphorylating TRPM7 and other substrates. TRPM7 can mediate sensory transmission, regulate cellular Ca2+ and Mg2+ homeostasis and affect embryonic development. Abnormal expression and/or activity of the TRPM7 channel kinase is involved in a variety of diseases, particularly the development and progression of cancer. TRPM7 channel-kinase is essential for cellular processes, such as proliferation, survival, differentiation, growth, and migration.
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078; Hunan Cancer Hospital, Changsha 410013, China.
authors.forename: Chenhui
authors.initials: C
authors.lastname: Luo
authors.affiliation: Hunan Cancer Hospital, Changsha 410013, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hunan Cancer Hospital, Changsha 410013, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D002118:Calcium; D002454:Cell Differentiation; D006801:Humans; D009369:Neoplasms; D017346:Protein Serine-Threonine Kinases; D050053:TRPM Cation Channels
chemical_list: D050053:TRPM Cation Channels; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human; D002118:Calcium