title: High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.
abstract: BACKGROUND
  B-Acute lymphoblastic leukemia (B-ALL) represents a hematologic malignancy with poor clinical outcome and low survival rates in adult patients. Remission rates in Hispanic population are almost 30% lower and Overall Survival (OS) nearly two years inferior than those reported in other ethnic groups. Only 61% of Colombian adult patients with ALL achieve complete remission (CR), median overall survival is 11.3 months and event-free survival (EFS) is 7.34 months. Identification of prognostic factors is crucial for the application of proper treatment strategies and subsequently for successful outcome. Our goal was to identify a gene expression signature that might correlate with response to therapy and evaluate the utility of these as prognostic tool in hispanic patients.
  
  
  METHODS
  We included 43 adult patients newly diagnosed with B-ALL. We used microarray analysis in order to identify genes that distinguish poor from good response to treatment using differential gene expression analysis. The expression profile was validated by real-time PCR (RT-PCT).
  
  
  RESULTS
  We identified 442 differentially expressed genes between responders and non-responders to induction treatment. Hierarchical analysis according to the expression of a 7-gene signature revealed 2 subsets of patients that differed in their clinical characteristics and outcome.
  
  
  CONCLUSIONS
  Our study suggests that response to induction treatment and clinical outcome of Hispanic patients can be predicted from the onset of the disease and that gene expression profiles can be used to stratify patient risk adequately and accurately. The present study represents the first that shows the gene expression profiling of B-ALL Colombian adults and its relevance for stratification in the early course of disease.
authors.affiliation: Programa de Investigación e Innovación en Leucemias Agudas y Crónicas (PILAC), Instituto Nacional de Cancerología, Bogotá, Colombia.|Group of Investigation in Biology of Cancer, Instituto Nacional de Cancerología, Calle 1 # 9-85, Bogotá, Colombia.|Programa de Doctorado en Ciencias Biológicas, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Nataly
authors.initials: N
authors.lastname: Cruz-Rodriguez
authors.affiliation: Programa de Investigación e Innovación en Leucemias Agudas y Crónicas (PILAC), Instituto Nacional de Cancerología, Bogotá, Colombia. acombita@cancer.gov.co.|Group of Investigation in Biology of Cancer, Instituto Nacional de Cancerología, Calle 1 # 9-85, Bogotá, Colombia. acombita@cancer.gov.co.|Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia. acombita@cancer.gov.co.
authors.forename: Alba L
authors.initials: AL
authors.lastname: Combita
authors.affiliation: Programa de Investigación e Innovación en Leucemias Agudas y Crónicas (PILAC), Instituto Nacional de Cancerología, Bogotá, Colombia.|Grupo de Hemato Oncología, Instituto Nacional de Cancerología, Bogotá, Colombia.
authors.forename: Leonardo J
authors.initials: LJ
authors.lastname: Enciso
authors.affiliation: Grupo de Inmunobiología y Biología Celular, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.|Hospital Universitario San Ignacio, Bogotá, Colombia.
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Quijano
authors.affiliation: Group of Investigation in Biology of Cancer, Instituto Nacional de Cancerología, Calle 1 # 9-85, Bogotá, Colombia.
authors.forename: Paula L
authors.initials: PL
authors.lastname: Pinzon
authors.affiliation: Group of Investigation in Biology of Cancer, Instituto Nacional de Cancerología, Calle 1 # 9-85, Bogotá, Colombia.
authors.forename: Olga C
authors.initials: OC
authors.lastname: Lozano
authors.affiliation: Programa de Investigación e Innovación en Leucemias Agudas y Crónicas (PILAC), Instituto Nacional de Cancerología, Bogotá, Colombia.
authors.forename: Juan S
authors.initials: JS
authors.lastname: Castillo
authors.affiliation: Stanley S. Scott Cancer Center, Center Louisiana State University Health Sciences Center Louisiana Cancer Research Center, 1700 Tulane Ave, Room 909, New Orleans, LA, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Universidad CES, Medellin, Colombia.
authors.forename: Jose
authors.initials: J
authors.lastname: Bareño
authors.affiliation: Hospital Universitario San Ignacio, Bogotá, Colombia.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cardozo
authors.affiliation: Hospital Universitario San Ignacio, Bogotá, Colombia.
authors.forename: Julio
authors.initials: J
authors.lastname: Solano
authors.affiliation: Hospital Universitario San Ignacio, Bogotá, Colombia.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Herrera
authors.affiliation: Hospital Universitario San Ignacio, Bogotá, Colombia.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cudris
authors.affiliation: Stanley S. Scott Cancer Center, Center Louisiana State University Health Sciences Center Louisiana Cancer Research Center, 1700 Tulane Ave, Room 909, New Orleans, LA, USA. jzabal@lsuhsc.edu.|Department of Pediatrics, Center Louisiana State University Health Sciences Center Louisiana Cancer Research Center, 1700 Tulane Ave, Room 909, New Orleans, LA, USA. jzabal@lsuhsc.edu.
authors.forename: Jovanny
authors.initials: J
authors.lastname: Zabaleta
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D007144:Immunoglobulin J-Chains / Q000235:genetics*; D051798:Inhibitor of Differentiation Protein 1 / Q000235:genetics*; D051796:Inhibitor of Differentiation Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000208:ethnology* / Q000235:genetics; D012074:Remission Induction; D016019:Survival Analysis; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C497453:ID1 protein, human; D007144:Immunoglobulin J-Chains; D051798:Inhibitor of Differentiation Protein 1; D051796:Inhibitor of Differentiation Proteins; D009363:Neoplasm Proteins; C075640:ID3 protein, human
keywords: Acute lymphoblastic leukemia; Complete remission; Gene expression profile; Minimal residual disease; Translational research