title: Invasive aspergillosis in a paediatric allogeneic stem cell transplantation recipient owing to a susceptible Aspergillus fumigatus: Treatment failure with high doses of voriconazole and influence of CYP2C19 polymorphisms.
authors.affiliation: Microbiology Department, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Cendejas-Bueno
authors.affiliation: Clinical Pharmacology Department, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain.
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Borobia
authors.affiliation: Mycology Department, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Gomez-Lopez
authors.affiliation: Paediatric Infectious Diseases Unit, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Escosa-García
authors.affiliation: Pediatric Intensive Care Unit, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Río-García
authors.affiliation: Paediatric Hematology-Oncology Department, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Plaza
authors.affiliation: Microbiology Department, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: García-Rodriguez
authors.affiliation: Clinical Pharmacology Department, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain. Electronic address: Antonio.carcas@gmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carcas-Sansuán
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000302:isolation & purification; D002675:Child, Preschool; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics*; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D011110:Polymorphism, Genetic; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D066027:Transplant Recipients; D014184:Transplantation, Homologous / Q000009:adverse effects; D017211:Treatment Failure; D065819:Voriconazole / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D065819:Voriconazole