title: MP-AzeFlu is more effective than fluticasone propionate for the treatment of allergic rhinitis in children.
abstract: The objective was to evaluate the efficacy of MP-AzeFlu (Dymista(®) ) vs fluticasone propionate (FP), (both 1 spray/nostril bid), in children with allergic rhinitis (AR). MP-AzeFlu combines azelastine hydrochloride, FP and a novel formulation in a single spray. Children were randomized in a 3 : 1 ratio to MP-AzeFlu or FP in this open-label, 3-month study. Efficacy was assessed in children aged ≥ 6 to <12 years (MP-AzeFlu: n = 264; FP: n = 89), using a 4-point symptom severity rating scale from 0 to 3 (0 = no symptoms; 3 = severe symptoms). Over the 3-month period, MP-AzeFlu-treated children experienced significantly greater symptom relief than FP-treated children (Diff: -0.14; 95% CI: -0.28, -0.01; P = 0.04), noted from the first day (particularly the first 7 days) and sustained for 90 days. More MP-AzeFlu children achieved symptom-free or mild symptom severity status, and did so up to 16 days faster than FP. MP-AzeFlu provides significantly greater, more rapid and clinically relevant symptom relief than FP in children with AR.
authors.affiliation: Division of Basic Clinical Immunology, School of Medicine, University of California, Irvine, CA, USA.|Allergy & Asthma Associates, Mission Viejo, CA, USA.
authors.forename: W
authors.initials: W
authors.lastname: Berger
authors.affiliation: University Hospital, Montpellier, France.|MACVIA-LR, Contre les Maladies Chronique pour un Vieillissement Actif en Languedoc Roussilon, European Innovation Partnership on Active and Healthy Aging Reference Site, Montpellier, France.|INSERM, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, U1168, Paris, France.|UVSQ UMR-S1168, Universite Versailles St-Quentin-en-Yvelines, Versailles, France.
authors.forename: J
authors.initials: J
authors.lastname: Bousquet
authors.affiliation: King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: A T
authors.initials: AT
authors.lastname: Fox
authors.affiliation: Allergology Department, Centre de l'Asthme et des Allergies. Hôpital d'Enfants Armand-Trousseau (APHP), Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe EPAR, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Just
authors.affiliation: Department of Mother and Child Health, Padua General University Hospital, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Muraro
authors.affiliation: Pediatric Allergy and Pneumology Unit, Children's Hospital La Fe, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.affiliation: Department of Lung Disease & Clinical Immunology, University of Turku, Turku, Finland.|Terveystalo Allergy Center, Turku, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Valovirta
authors.affiliation: National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.|Department of Pediatrics, Sachs' Children's Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Wickman
authors.affiliation: Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wahn
mesh_terms: D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D000068298:Fluticasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006633:Histamine Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D065631:Rhinitis, Allergic / Q000175:diagnosis / Q000188:drug therapy*; D063189:Symptom Assessment; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D004338:Drug Combinations; D006633:Histamine Antagonists; D000068298:Fluticasone
keywords: Dymista; MP29-02; children; fluticasone propionate