title: Association of chemokine ligand 5/chemokine receptor 5 gene promoter polymorphisms with diabetic microvascular complications: A meta-analysis.
abstract: Chemokine ligand 5 (CCL5) is a member of the CC-chemokine family expressed in various organs. It contributes to the migration of monocytes/macrophages into injured vascular walls by binding with its receptor chemokine receptor 5 (CCR5). Many studies have accessed the association between CCL5/CCR5 gene promoter polymorphisms and diabetic microvascular complications (DMI). However, the results are conflicting and inconclusive. The aim of the present study was to evaluate the association more precisely.
  
  
  
  Trials were retrieved through PubMed, Embase, Medline, China National Knowledge Infrastructure, Web of Science and Cochrane database without restrictions on language. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to describe the strength of association with DMI.
  
  
  
  Data were obtained from 11 case-control studies that included 2,737 DMI patients and 2,435 diabetic control subjects. In the overall analysis, the CCL5-403 G/A and CCL5-28 C/G gene polymorphisms were not significantly associated with the risk of DMI. However, CCR5-59029 G/A was an independent risk factor of DMI in a dominant model (OR 1.77, 95% CI 1.06-2.97). Subgroup analysis showed that the risk of the CCR5 59029A-positive genotype was significant in Asians (OR 2.08, 95% CI 1.68-2.57). In addition, the CCR5 59029A-positive genotype was associated with increased risk of albuminuria.
  
  
  
  There were no associations of CCL5 gene promoter polymorphism with the risk of DMI. However, the 59029A polymorphism in CCR5 might affect individual susceptibility for DMI.
authors.affiliation: Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan China; Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan China.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Division of Endocrinology Department of Medicine Qilu Hospital of Shandong University Jinan China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Cadres Health care Qilu Hospital of Shandong University Qingdao China.
authors.forename: Weiyi
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Endocrinology Tengzhou Central People's Hospital Tengzhou China.
authors.forename: Fupeng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan China.
authors.forename: Junyu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Wu
authors.affiliation: Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Guan
authors.affiliation: Laboratory of Microvascular Medicine and Medical Research Center Shandong Provincial Qianfoshan Hospital Shandong University Jinan China.
authors.forename: Ju
authors.initials: J
authors.lastname: Liu
authors.affiliation: Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liao
mesh_terms: D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D006801:Humans; D055806:Microvessels / Q000473:pathology; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C483024:CCL5 protein, human; C584933:CCR5 protein, human; D018946:Chemokine CCL5; D019713:Receptors, CCR5
keywords: Chemokine ligand 5; Chemokine receptor 5; Diabetes mellitus