title: Dual-modality self-heating and antibacterial polymer-coated nanoparticles for magnetic hyperthermia.
abstract: Multifunctional nanoparticles for magnetic hyperthermia which simultaneously display antibacterial properties promise to decrease bacterial infections co-localized with cancers. Current methods synthesize such particles by multi-step procedures, and systematic comparisons of antibacterial properties between coatings, as well as measurements of specific absorption rate (SAR) during magnetic hyperthermia are lacking. Here we report the novel simple method for synthesis of magnetic nanoparticles with shells of oleic acid (OA), polyethyleneimine (PEI) and polyethyleneimine-methyl cellulose (PEI-mC). We compare their antibacterial properties against single gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria as well as biofilms. Magnetite nanoparticles (MNPs) with PEI-methyl cellulose were found to be most effective against both S. aureus and E. coli with concentration for 10% growth inhibition (EC10) of <150 mg/l. All the particles have high SAR and are effective for heat-generation in alternating magnetic fields.
authors.affiliation: Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 2, 461 17 Liberec, Czech Republic; Egyptian Petroleum Research Institute, 1 Ahmed El-Zomor Street, El Zohour Region, Nasr City, 11727 Cairo, Egypt; Department of Materials Science and Metallurgy, 27 Charles Babbage Road, University of Cambridge, CB3 0FS, United Kingdom.
authors.forename: Mohamed S A
authors.initials: MS
authors.lastname: Darwish
authors.affiliation: Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 2, 461 17 Liberec, Czech Republic.
authors.forename: Nhung H A
authors.initials: NH
authors.lastname: Nguyen
authors.affiliation: Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 2, 461 17 Liberec, Czech Republic.
authors.forename: Alena
authors.initials: A
authors.lastname: Ševců
authors.affiliation: Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 2, 461 17 Liberec, Czech Republic.
authors.forename: Ivan
authors.initials: I
authors.lastname: Stibor
authors.affiliation: Department of Materials Science and Metallurgy, 27 Charles Babbage Road, University of Cambridge, CB3 0FS, United Kingdom. Electronic address: sks46@cam.ac.uk.
authors.forename: Stoyan K
authors.initials: SK
authors.lastname: Smoukov
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology; D006979:Hyperthermia, Induced; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008747:Methylcellulose / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D058185:Magnetite Nanoparticles; D011094:Polyethyleneimine; D008747:Methylcellulose
keywords: Antibacterial properties; Hyperthermia; Magnetic; Self-heating