title: Synthesis and Cell Imaging of a Near-Infrared Fluorescent Magnetic "CdHgTe-Dextran-Magnetic Layered Double Hydroxide-Fluorouracil" Composite.
abstract: In this article, a water-soluble near-infrared quantum dots of CdHgTe were prepared and subsequently combined with the drug delivery system "dextran-magnetic layered double hydroxide-fluorouracil" (DMF) to build a new nanostructure platform in form of CdHgTe@DMF, in which the fluorescent probe function of quantum dots and the magnetic targeting transport and slow-release curative effect of DMF were blended availably together. The luminescent property particle size, and internal structure of the composite were characterized using fluorescence spectrophotometer, ultraviolet spectrophotometer, laser particle size distribution, TEM, X-ray diffraction, and Fourier transform infrared. The experimental study on fluorescent tags effect and magnetic targeting performance of the multifunctional platform were performed by fluorescent confocal imaging. The results showed that the CdHgTe could be grafted successfully onto the surface of DMF by electrostatic coupling. The CdHgTe@DMF composite showed super-paramagnetic and photoluminescence property in the near-infrared wavelength range of 575-780 nm. Compared with CdHgTe, the CdHgTe@DMF composite could significantly improve the cell imaging effect, the label intensity increased with the magnetic field intensity, and obeyed the linear relationship Dmean = 1.758 + 0.0075M under the conditions of magnetic field interference. It can be implied that the CdHgTe@DMF may be an effective multifunction tool applying to optical bioimaging and magnetic targeted therapy.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: XueQin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. Electronic address: ggj1964@163.com.
authors.forename: GuoJing
authors.initials: G
authors.lastname: Gou
authors.affiliation: Department of Traditional Chinese Medicine, The Beijing Moslem People's Hospital, Beijing 100054, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
mesh_terms: D019187:Cadmium Compounds / Q000138:chemical synthesis*; D045744:Cell Line, Tumor; D003911:Dextrans / Q000138:chemical synthesis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D005472:Fluorouracil / Q000138:chemical synthesis*; D006801:Humans; D006878:Hydroxides / Q000138:chemical synthesis; D008280:Magnetics; D017669:Mercury Compounds / Q000138:chemical synthesis*; D057054:Molecular Imaging / Q000379:methods; D045663:Quantum Dots / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D019187:Cadmium Compounds; D003911:Dextrans; D005456:Fluorescent Dyes; D006878:Hydroxides; D017669:Mercury Compounds; C104191:mercury cadmium telluride; C031356:hydroxide ion; D005472:Fluorouracil
keywords: Fourier transform infrared; UV/Vis spectroscopy; X-ray diffractometry; cell culture; fluorescence spectroscopy; nanoparticles; near-infrared imaging; physical characterization; synthesis; targeted drug delivery