title: One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies.
abstract: Two operationally simple one-pot protocols have been developed for the synthesis of amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines. Optimization data and substrate scope for these atom-economical transformations, which engage commercially available o-phenylenediamines and o-cyanobenzaldehydes, are discussed.
authors.affiliation: Department of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
authors.forename: Alex L
authors.initials: AL
authors.lastname: Bagdasarian
authors.affiliation: Department of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
authors.forename: Huy H
authors.initials: HH
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Palazzo
authors.affiliation: Department of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
authors.forename: James C
authors.initials: JC
authors.lastname: Fettinger
authors.affiliation: Department of Chemistry, American University of Beirut , Beirut 1107 2020, Lebanon.
authors.forename: Makhluf J
authors.initials: MJ
authors.lastname: Haddadin
authors.affiliation: Department of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D007546:Isoquinolines; D011810:Quinoxalines; C000621888:benzo(4,5)imidazo(2,1-a)isoquinoline; C000621890:isoquinolino(3,4-b)quinoxaline