title: Phylogenetic and forensic studies of the Bangladeshi population using next-generation PowerPlex® Y23 STR marker system.
abstract: Haplotype diversity and allele frequencies of 23 Y chromosomal short tandem repeat (STR) loci included in the next-generation PowerPlex® Y23 System were studied in 137 Bangladeshi Bengali males. A total of 134 different haplotypes were observed with a discrimination capacity (DC) of 0.978, indicating a high potential for differentiating between male individuals in this population. The highest allele frequency (0.818) was observed in locus DYS391. Locus DYS385a/b showed the highest gene diversity (0.945) while locus DYS391 showed the lowest gene diversity (0.302). Double alleles were detected in three loci. On the other hand, four null alleles were detected in a single haplotype at DYS448, DYS549, DYS392, and DYS385a/b locus, respectively. The haplotype data is available in the Y chromosome haplotype reference database under accession number YA003445. To understand the genetic diversity of Bangladeshi Bengali population, a pairwise genetic distances (Rst) was calculated by comparing with 23 population studies consisting 4249 haplotypes. The analysis placed the Bangladeshi population along with Indian Tamil and Indo-Pakistani population in a clade separated from the rest.
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College Campus, Dhaka, 1000, Bangladesh.
authors.forename: Md Mahamud
authors.initials: MM
authors.lastname: Hasan
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College Campus, Dhaka, 1000, Bangladesh.
authors.forename: Pilu
authors.initials: P
authors.lastname: Momtaz
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College Campus, Dhaka, 1000, Bangladesh.
authors.forename: Tania
authors.initials: T
authors.lastname: Hossain
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College Campus, Dhaka, 1000, Bangladesh.
authors.forename: Ashish Kumar
authors.initials: AK
authors.lastname: Mazumder
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College Campus, Dhaka, 1000, Bangladesh.
authors.forename: Md Jabedul Alam
authors.initials: MJ
authors.lastname: Khondaker
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College Campus, Dhaka, 1000, Bangladesh.
authors.forename: Abu
authors.initials: A
authors.lastname: Sufian
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh.
authors.forename: Md Niaz
authors.initials: MN
authors.lastname: Makhdum
authors.affiliation: Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, 1000, Bangladesh. sharif_akhteruzzaman@yahoo.com.
authors.forename: Sharif
authors.initials: S
authors.lastname: Akhteruzzaman
mesh_terms: D001459:Bangladesh; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010802:Phylogeny; D016133:Polymerase Chain Reaction
chemical_list: D005819:Genetic Markers
keywords: Duplicate allele; Forensic; Gene diversity; Haplotype; Null allele; PowerPlex Y23; Y-STR