title: Protective effects of resveratrol on aging-induced cognitive impairment in rats.
abstract: Resveratrol, a polyphenol phytoalexine, has been shown to play a neuroprotective role in the neurodegenerative process in Alzheimer's disease (AD) and improve memory function in dementia. However, the in vivo effect of resveratrol in normal aging models of learning and memory has not yet been evaluated. Therefore, the present neurobehavioral study was undertaken to evaluate the effect of resveratrol on cognitive impairment induced by aging in passive avoidance and Morris water maze (MWM) tests. Male Wistar albino rats were divided into four groups: young control (4month), young resveratrol (4month+RESV), old control (24month) and old resveratrol (24month+RESV). Resveratrol (50mg/kg/day) was given to the 4month+RESV and 24month+RESV groups orally for 12weeks. There was no significant difference between the groups for the first day of latency, while in aged rats, the second day of latency was significantly shortened compared to the young group in the passive avoidance test (p<0.05). Additionally, in the MWM test, the results showed a decrease in the time spent in the escape platform's quadrant in the probe test in aged rats (p<0.05). The administration of resveratrol at 50mg/kg/day increased the retention scores in the passive avoidance test and the time spent in the escape platform's quadrant in the MWM task (p<0.05). Furthermore resveratrol attenuated the protein levels of TNFα and IL1β in the 24-month group. These findings indicate that aging impairs emotional and spatial learning-memory and resveratrol reverses the effect of age-related learning and memory impairment. The results of this study suggest that resveratrol is effective in preventing cognitive deficit in aged rats by inhibiting the production of inflammatory cytokines.
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey. Electronic address: selcengmez@yahoo.com.
authors.forename: Semil Selcen
authors.initials: SS
authors.lastname: Gocmez
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey.
authors.forename: Nejat
authors.initials: N
authors.lastname: Gacar
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey; Kocaeli University, Experimental Medical Research and Application Centre, Kocaeli, Turkey.
authors.forename: Tijen
authors.initials: T
authors.lastname: Utkan
authors.affiliation: Kocaeli University, Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli, Turkey.
authors.forename: Gulcin
authors.initials: G
authors.lastname: Gacar
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL, United States.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Scarpace
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL, United States; Geriatric Research, Education, and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, United States.
authors.forename: Nihal
authors.initials: N
authors.lastname: Tumer
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000188:drug therapy* / Q000503:physiopathology*; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D017208:Rats, Wistar; D000077185:Resveratrol; D065853:Spatial Learning / Q000187:drug effects / Q000502:physiology*; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D013267:Stilbenes; D000077185:Resveratrol
keywords: Aging; Inflammatory cytokines; Learning and memory; Resveratrol