title: Metal free carboamination of internal alkynes--an easy access to polysubstituted quinolines.
abstract: A metal free carboamination of unactivated alkynes towards highly substituted quinolines was realized in the presence of a synergistic Brønsted acid catalyst system. Supported by mechanistic probes, the reaction proceeds via a highly reactive vinyl cation in a C-C bond formation--Schmidt reaction sequence. The irreversible extrusion of N2, as a powerful driving force, allows for a general conversion of poorly nucleophilic aliphatic alkynes.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany. niggemann@oc.rwth-aachen.de.
authors.forename: T
authors.initials: T
authors.lastname: Stopka
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany. niggemann@oc.rwth-aachen.de.
authors.forename: M
authors.initials: M
authors.lastname: Niggemann