title: Sequential therapy with "vacuum sealing drainage-artificial dermis implantation-thin partial thickness skin grafting" for deep and infected wound surfaces in children.
abstract: To evaluate the efficacy of a "vacuum sealing drainage (VSD) - artificial dermis implantation (ADI) - thin partial thickness skin grafting (TSG)" sequential therapy for deep and infected wounds in children.
  
  
  
  Fifty-three pediatric patients with deep and infected wounds were treated with sequential VSD-ADI-TSG therapy. The efficacy of this treatment was compared with that of the surgical debridement-change dressings-thin partial thickness skin grafting previously performed on 20 patients. Survival of tissue grafts, color and flexibility, subcutaneous fullness and scar formation of the graft site were examined and compared.
  
  
  
  The sequential therapy combined the advantages of the VSD treatment, in reducing tissue necrosis and infection on the wound surfaces and promoting the growth of granulation tissue, with the enhancement of grafting by artificial dermis. Compared with the 20 controls, skin grafted on the artificial dermis was more smooth and glossy, while the textures of the region were more elastic, and the scars were significantly lighter in Vancouver scale.
  
  
  
  The sequential VSD-ADI-TSG therapy is a simple and effective treatment for children with deep and infected wounds.
  
  
  
  IV.
authors.affiliation: Children's Hospital of Chongqing Medical University, Department of Burns and Plastic Surgery, No. 136, Zhongshan 2nd Road, 400014 Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: X-G
authors.initials: XG
authors.lastname: Yuan
authors.affiliation: Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Children's Hospital of Chongqing Medical University, Department of Burns and Plastic Surgery, No. 136, Zhongshan 2nd Road, 400014 Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: Y-X
authors.initials: YX
authors.lastname: Fu
authors.affiliation: Children's Hospital of Chongqing Medical University, Department of Burns and Plastic Surgery, No. 136, Zhongshan 2nd Road, 400014 Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: X-F
authors.initials: XF
authors.lastname: Tian
authors.affiliation: Children's Hospital of Chongqing Medical University, Department of Burns and Plastic Surgery, No. 136, Zhongshan 2nd Road, 400014 Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Children's Hospital of Chongqing Medical University, Department of Burns and Plastic Surgery, No. 136, Zhongshan 2nd Road, 400014 Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Children's Hospital of Chongqing Medical University, Department of Burns and Plastic Surgery, No. 136, Zhongshan 2nd Road, 400014 Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: T-W
authors.initials: TW
authors.lastname: Li
authors.affiliation: Children's Hospital of Chongqing Medical University, Department of Burns and Plastic Surgery, No. 136, Zhongshan 2nd Road, 400014 Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002), Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China. Electronic address: qiulin118@126.com.
authors.forename: L
authors.initials: L
authors.lastname: Qiu
mesh_terms: D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000209:etiology; D003646:Debridement; D005260:Female; D006085:Graft Survival; D006801:Humans; D008297:Male; D009336:Necrosis / Q000517:prevention & control; D054843:Negative-Pressure Wound Therapy; D012867:Skin / Q000473:pathology*; D016038:Skin Transplantation; D017768:Skin, Artificial; D018461:Soft Tissue Infections / Q000150:complications / Q000517:prevention & control / Q000601:surgery*; D017695:Soft Tissue Injuries / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome; D014618:Vacuum; D014945:Wound Healing
keywords: Artificial dermis; Children; Thin partial thickness skin grafting; Vacuum sealing drainage