title: Major Pulmonary Complications After Hematopoietic Stem Cell Transplant.
abstract: Both autologous and allogeneic hematopoietic stem cell transplants are important therapeutic options for several benign and malignant disorders. Pulmonary complications, although they have become less frequent, remain a significant cause of morbidity and mortality after hematopoietic stem cell transplant. These complications range from bacterial, fungal, and viral pulmonary infections to noninfectious conditions such as diffuse alveolar hemorrhage and idiopathic pneumonia syndrome. Bronchiolitis obliterans syndrome is the primary chronic pulmonary complication, and treatment of this condition remains challenging. This report highlights the advances in the diagnosis and management of the major pulmonary complications after hematopoietic stem cell transplant. It also underscores the need for prospective and multicenter research to have a better understanding of the mechanisms behind these complications and to obtain more effective diagnostic tool and therapeutic options.
authors.affiliation: From the Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Diab
authors.forename: Jihane
authors.initials: J
authors.lastname: ZazaDitYafawi
authors.forename: Ayman O
authors.initials: AO
authors.lastname: Soubani
mesh_terms: D001989:Bronchiolitis Obliterans / Q000209:etiology; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D011237:Predictive Value of Tests; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D012141:Respiratory Tract Infections / Q000209:etiology; D012307:Risk Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome