title: Fibrous Dysplasia Presenting as a Cold Spot in 18F-FLT PET/CT Imaging.
abstract: Fibrous dysplasia (FD) is a benign bone lesion in which normal bone marrow is replaced by fibro-osseous tissue. The usual high fluorodeoxyglucose (F-FDG) uptake in FD may lead to the misdiagnosis of bone malignancy. Herein, we describe the case of a 42-year old man with histologically verified FD of the pubic bone, which has been subsequently examined during follow-up for rectal cancer, using both F-FDG and fluorothymidine (F-FLT) PET/CT imaging. The FD lesion was characterized by a high uptake of F-FDG (hot spot) but very low uptake of F-FLT (cold spot) as compared with the contralateral unaffected pubic bone.
authors.affiliation: From the *Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University and Masaryk Memorial Cancer Institute, Zluty kopec, Brno, Czech Republic; †Department of Nuclear Medicine, PET Center, RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec, Brno, Czech Republic; ‡1st Department of Pathological Anatomy, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Pekarska, Brno, Czech Republic; and §Department of Radiation Oncology, Faculty of Medicine, Masaryk University and Masaryk Memorial Cancer Institute, Zluty kopec, Brno, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Rehak
authors.forename: Beatrix
authors.initials: B
authors.lastname: Bencsikova
authors.forename: Iva
authors.initials: I
authors.lastname: Zambo
authors.forename: Tomas
authors.initials: T
authors.lastname: Kazda
mesh_terms: D000328:Adult; D015224:Dideoxynucleosides; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D011630:Pubic Bone / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals
chemical_list: D015224:Dideoxynucleosides; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C002854:alovudine