title: Determinants of Chronic Total Occlusion in Patients With Peripheral Arterial Occlusive Disease.
abstract: Chronic total occlusion (CTO) is a common finding in 40% of the patients with peripheral arterial disease (PAD). The aim of this study was to investigate the determinants of CTO in patients with PAD. The study included a total of 211 nonanemic patients with PAD. All patients were categorized according to the Fontaine classification. In lower extremity angiography cohorts, CTO-patients were designated as group 1 and CTO+patients were designated as group 2. Patients with CTO had significantly higher red cell distribution width (RDW), neutrophil-lymphocyte ratio, uric acid, and high-sensitivity C-reactive protein compared to patients without CTO ( P ≤ .001, P = .036, P ≤ .001, and P = .015, respectively). Albumin, total bilirubin, and direct bilirubin were significantly lower in the patients with CTO compared to patients without CTO ( P = .023, P ≤ .001, and P = .049, respectively). Multivariate logistic regression analysis showed that RDW, uric acid, and total bilirubin were independent predictors of CTO in patients with PAD. We demonstrated that increased RDW and uric acid levels and lower total bilirubin values were independently associated with CTO in patients with PAD.
authors.affiliation: 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Hikmet
authors.initials: H
authors.lastname: Hamur
authors.affiliation: 2 Department of Cardiovascular Surgery, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Oruc Alper
authors.initials: OA
authors.lastname: Onk
authors.affiliation: 3 Department of Cardiology, Dr. Ersin Arslan State Hospital, Gaziantep, Turkey.
authors.forename: Ertan
authors.initials: E
authors.lastname: Vuruskan
authors.affiliation: 4 Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Duman
authors.affiliation: 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Eftal Murat
authors.initials: EM
authors.lastname: Bakirci
authors.affiliation: 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kucuksu
authors.affiliation: 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Husnu
authors.initials: H
authors.lastname: Degirmenci
authors.affiliation: 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Buyuklu
authors.affiliation: 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
authors.forename: Ergun
authors.initials: E
authors.lastname: Topal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000473:pathology*; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000473:pathology*; D011237:Predictive Value of Tests; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein; D001663:Bilirubin
keywords: bilirubin; chronic total occlusion; peripheral arterial disease; red cell distribution width; uric acid