title: Increased antimüllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome.
abstract: To investigate for differences in reproductive hormone levels in male relatives of women with polycystic ovary syndrome (PCOS).
  
  
  
  Cross-sectional study.
  
  
  
  Academic medical center.
  
  
  
  Sixty-three fathers and 66 brothers of women with PCOS as well as two groups of control men of comparable age to fathers (older control, n = 30) and brothers (younger control, n = 58).
  
  
  
  A single early morning fasting blood sample was obtained for the measurement of reproductive hormone levels.
  
  
  
  Testosterone, LH, FSH, antimüllerian hormone (AMH), inhibin B, estradiol (E2), and estrone (E1) levels were measured.
  
  
  
  The AMH, LH, and FSH levels were significantly increased in male relatives compared with their respective control groups. The levels of E2, E1, T, and inhibin B did not differ between the groups.
  
  
  
  The AMH, LH, and FSH levels were increased in adult male relatives of women with PCOS, suggesting that they may have altered testicular function and changes in neuroendocrine regulation of gonadotropin secretion. These changes may reflect effects of PCOS susceptibility genes such as the recently mapped chromosome 11p14.1 locus in the region of the FSH B polypeptide gene.
authors.affiliation: Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Torchen
authors.affiliation: Ansh Labs, Webster, Texas.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Ansh Labs, Webster, Texas.
authors.forename: Bhanu
authors.initials: B
authors.lastname: Kalra
authors.affiliation: Ansh Labs, Webster, Texas.
authors.forename: Gopal
authors.initials: G
authors.lastname: Savjani
authors.affiliation: Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Ryan
authors.initials: R
authors.lastname: Sisk
authors.affiliation: Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
authors.affiliation: Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois. Electronic address: a-dunaif@northwestern.edu.
authors.forename: Andrea
authors.initials: A
authors.lastname: Dunaif
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000368:Aged; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005220:Fathers; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D012098:Reproduction / Q000235:genetics*; D060728:Reproductive Health; D035781:Siblings; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone
keywords: Polycystic ovary syndrome; antimüllerian hormone; first degree relatives; gonadotropins