title: Polysaccharides based nanomaterials for targeted anti-cancer drug delivery.
abstract: Polysaccharides, an important class of biological polymers, are effectively bioactive, nontoxic, hydrophilic, biodegradable and offer a wide diversity in structure and properties. These can be easily modified chemically and biochemically to enhance the bioadhesion with biological tissues, better stability and can improve bioavailability of drugs. Most of the chemotherapeutic drugs have a narrow therapeutic index, slow drug delivery systems and poor water solubility that usually proves toxic to human bodies. The inherent biocompatibility of these biopolymers have shown enhancement of solubility of some chemotherapeutic drugs which also leads to the preparation of nanomaterials for the delivery of antibiotics, anticancer, proteins, peptides and nucleic acids using several routes of administration. Recently, synthesis and research on polysaccharides based nanomaterials have gained enormous attention as one of the most applicable resources in nanomedicine area. This review article will provide a specific emphasis on polysaccharides as natural biomaterials for targeted anticancer drug delivery system.
authors.affiliation: a Academy of Scientific and Innovative Research (AcSIR) , Jammu Campus , Jammu , India.|b Bio-Organic Chemistry Division, Indian Institute of Integrative Medicine , CSIR , Canal Road , Jammu , India.
authors.forename: Divya
authors.initials: D
authors.lastname: Dheer
authors.affiliation: a Academy of Scientific and Innovative Research (AcSIR) , Jammu Campus , Jammu , India.|c Quality Control, Quality Assurance and CMC Division, Indian Institute of Integrative Medicine , CSIR , Canal Road , Jammu , India.
authors.forename: Divya
authors.initials: D
authors.lastname: Arora
authors.affiliation: a Academy of Scientific and Innovative Research (AcSIR) , Jammu Campus , Jammu , India.|c Quality Control, Quality Assurance and CMC Division, Indian Institute of Integrative Medicine , CSIR , Canal Road , Jammu , India.
authors.forename: Sundeep
authors.initials: S
authors.lastname: Jaglan
authors.affiliation: d Department of Pharmaceutical Chemistry , Indo-Soviet Friendship College of Pharmacy (ISFCP) , Moga , India.
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Rawal
authors.affiliation: a Academy of Scientific and Innovative Research (AcSIR) , Jammu Campus , Jammu , India.|b Bio-Organic Chemistry Division, Indian Institute of Integrative Medicine , CSIR , Canal Road , Jammu , India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Shankar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D002986:Clinical Trials as Topic; D004337:Drug Carriers / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D018014:Gene Transfer Techniques; D006801:Humans; D015394:Molecular Structure; D058990:Molecular Targeted Therapy; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D011134:Polysaccharides
keywords: Anti-cancer; chitosan; dextran; hyaluronic acid; nanoparticle; polysaccharide