title: BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli.
abstract: ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (NAc), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. In contrast, no regulation is seen in mice that are susceptible to this chronic stress. Viral-mediated overexpression of Baz1b, along with its associated subunit Smarca5, in mouse NAc is sufficient to potentiate both rewarding responses to cocaine, including cocaine self-administration, and resilience to chronic social defeat stress. However, despite these similar, proreward behavioral effects, genome-wide mapping of BAZ1B in NAc revealed mostly distinct subsets of genes regulated by these chromatin remodeling proteins after chronic exposure to either cocaine or social stress. Together, these findings suggest important roles for BAZ1B and its associated chromatin remodeling complexes in NAc in the regulation of reward behaviors to distinct emotional stimuli and highlight the stimulus-specific nature of the actions of these regulatory proteins.
  
  
  CONCLUSIONS
  We show that BAZ1B, a component of chromatin remodeling complexes, in the nucleus accumbens regulates reward-related behaviors in response to chronic exposure to both rewarding and aversive stimuli by regulating largely distinct subsets of genes.
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: HaoSheng
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Pharmacology and Toxicology and Institute on Addictions, The State University of New York at Buffalo, Buffalo, New York 14214, and.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Martin
authors.affiliation: Department of Pharmacology and Toxicology and Institute on Addictions, The State University of New York at Buffalo, Buffalo, New York 14214, and.
authors.forename: Craig T
authors.identifier: http://orcid.org/0000-0001-8387-777X
authors.initials: CT
authors.lastname: Werner
authors.affiliation: Department of Pharmacology and Toxicology and Institute on Addictions, The State University of New York at Buffalo, Buffalo, New York 14214, and.
authors.forename: Zi-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Damez-Werno
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Kimberly N
authors.initials: KN
authors.lastname: Scobie
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Ning-Yi
authors.identifier: http://orcid.org/0000-0003-4231-828X
authors.initials: NY
authors.lastname: Shao
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Caroline
authors.initials: C
authors.lastname: Dias
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Jacqui
authors.initials: J
authors.lastname: Rabkin
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Ja Wook
authors.initials: JW
authors.lastname: Koo
authors.affiliation: Department of Pharmacology and Toxicology and Institute on Addictions, The State University of New York at Buffalo, Buffalo, New York 14214, and.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Gancarz
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Ezekiell A
authors.identifier: http://orcid.org/0000-0003-0084-0897
authors.initials: EA
authors.lastname: Mouzon
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Rachael L
authors.initials: RL
authors.lastname: Neve
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Pharmacology and Toxicology and Institute on Addictions, The State University of New York at Buffalo, Buffalo, New York 14214, and.
authors.forename: David M
authors.identifier: http://orcid.org/0000-0002-6927-9236
authors.initials: DM
authors.lastname: Dietz
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, eric.nestler@mssm.edu.
authors.forename: Eric J
authors.identifier: http://orcid.org/0000-0002-7905-2000
authors.initials: EJ
authors.lastname: Nestler
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002843:Chromatin / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D003042:Cocaine / Q000494:pharmacology; D004644:Emotions / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D012646:Self Administration; D012931:Social Environment; D013315:Stress, Psychological; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*; D000092468:Bromodomain Containing Proteins
chemical_list: D000251:Adenosine Triphosphatases; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D003042:Cocaine; D014157:Transcription Factors; C485505:Baz1b protein, mouse; D000092468:Bromodomain Containing Proteins; C498725:Smarca5 protein, mouse
keywords: Addiction; Baz1b; chromatin; depression; epigenetics; remodeler