title: Obstructive sleep apnea and the risk of preterm delivery.
abstract: OBJECTIVE
  The aim of this study was to evaluate the risk of obstructive sleep apnea (OSA) to preterm delivery (PTD), using the Berlin Questionnaire (BQ).
  
  
  METHODS
  This was a large, prospective cohort study among pregnant Thai women. The BQ was employed for symptom-based OSA screening during the second trimester, and PTD was recorded in 1345 pregnant women. Multivariate models were applied in controlling for potential confounders.
  
  
  RESULTS
  The overall prevalence of the high risk of OSA was 10.1 %, and it was significantly associated with pre-pregnancy body mass index and score on the Perceived Stress Scale. An adjusted odds ratio for PTD in women with a high risk of OSA was 2.00 (95 % confidence intervals (CIs) = 1.20, 3.34). Stratified analyses, after adjusting for confounding factors, indicated that a high risk of OSA was associated with an increased risk of spontaneous preterm delivery (odds ratio (OR) = 2.45, 95 % CI = 1.20, 5.02), but not with preterm premature rupture of membranes (OR = 1.61, 95 % CI = 0.61, 4.26), and medically indicated preterm delivery (OR = 1.83, 95 % CI = 0.72, 4.64).
  
  
  CONCLUSIONS
  Pregnant women with a high risk of OSA are at an increased risk of having PTD, compared with pregnant women with a low risk of OSA.
authors.affiliation: Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.|Department of Physical Medicine and Rehabilitation, Maharat Nakhon Ratchasima Hospital, Amphur Muang, Nakhon Ratchasima Province, Thailand.
authors.forename: Kunyalak
authors.initials: K
authors.lastname: Na-Rungsri
authors.affiliation: Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Somrat
authors.initials: S
authors.lastname: Lertmaharit
authors.affiliation: Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Vitool
authors.initials: V
authors.lastname: Lohsoonthorn
authors.affiliation: Department of Obstetrics and Gynecology, Maharat Nakhon Ratchasima Hospital, Amphur Muang, Nakhon Ratchasima Province, Thailand.
authors.forename: Surachart
authors.initials: S
authors.lastname: Totienchai
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drboy48@yahoo.com.|Excellence Center for Sleep Disorders, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Phathumwan, Bangkok, 10330, Thailand. drboy48@yahoo.com.
authors.forename: Nattapong
authors.initials: N
authors.lastname: Jaimchariyatam
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007752:Obstetric Labor, Premature / Q000453:epidemiology* / Q000209:etiology*; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012306:Risk; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D013785:Thailand; D055815:Young Adult
keywords: Berlin Questionnaire; Obstructive sleep apnea; Pregnancy; Preterm delivery