title: Predictors of remission, erosive disease and radiographic progression in a Colombian cohort of early onset rheumatoid arthritis: a 3-year follow-up study.
abstract: The objective of the study is to find predictors of remission, radiographic progression (RP), and erosive disease in a cohort of patients with early onset rheumatoid arthritis (EORA) that followed a therapeutic protocol aiming at remission, in a real world tight-control setting. EORA patients were enrolled in a 3-year follow-up study. Clinical, biological, immunogenetic, and radiographical data were analyzed. Radiographs were scored according to Sharp-van der Heijde (SvdH) method. RP was defined by an increase of 3 units in 36 months. Remission was defined as DAS28 <2.6. A stepwise multiple logistic regression model was used to identify independent predictors of the three target outcomes. One hundred twenty-nine patients were included. Baseline disease activity was high. Significant overall improvement was observed, but only 33.3 % achieved remission. At 36 month, 50.4 % (65) of patients showed erosions. RP was observed in 62.7 % (81) of cases. Statistical analysis showed that baseline SvdH score was the only predictive factor associated with the three outcomes evaluated. Lower HAQ-DI and absence of autoantibodies were predictive of remission. Higher levels of ESR and presence of erosions at entry were predictive of RP. Independent baseline predictors of incident erosive disease were anti-CCP and RF positivity, symptom duration at baseline >3 months, and presence of HLA-DRB1 shared epitope. Radiographic damage at baseline was the main predictor of outcomes. Autoantibodies, HAQ and ESR at baseline, symptom duration before diagnosis, and HLA-DRB1 status had influence on clinical course and development of structural joint damage in Colombian RA patients.
authors.affiliation: Rheumatology Unit, Faculty of Medicine, National University of Colombia, Cra. 30 No. 45-03, Bldg 471, 5th Floor, Office 510, Bogota, Colombia. maquintanad@gmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Quintana-Duque
authors.affiliation: Rheumatology Unit, Faculty of Medicine, National University of Colombia, Cra. 30 No. 45-03, Bldg 471, 5th Floor, Office 510, Bogota, Colombia.
authors.forename: F
authors.initials: F
authors.lastname: Rondon-Herrera
authors.affiliation: Rheumatology Unit, Faculty of Medicine, National University of Colombia, Cra. 30 No. 45-03, Bldg 471, 5th Floor, Office 510, Bogota, Colombia.
authors.forename: R D
authors.initials: RD
authors.lastname: Mantilla
authors.affiliation: Radiology Unit, Faculty of Medicine, National University of Colombia, Bogota, Colombia.
authors.forename: E
authors.initials: E
authors.lastname: Calvo-Paramo
authors.affiliation: Pathology unit, Genetic Institute, Faculty of Medicine, National University of Colombia, Bogota, Colombia.
authors.forename: J J
authors.initials: JJ
authors.lastname: Yunis
authors.affiliation: Rheumatology Unit, Faculty of Medicine, National University of Colombia, Cra. 30 No. 45-03, Bldg 471, 5th Floor, Office 510, Bogota, Colombia.
authors.forename: A
authors.initials: A
authors.lastname: Varela-Nariño
authors.affiliation: Rheumatology Unit, Faculty of Medicine, National University of Colombia, Cra. 30 No. 45-03, Bldg 471, 5th Floor, Office 510, Bogota, Colombia.
authors.forename: J F
authors.initials: JF
authors.lastname: Restrepo
authors.affiliation: Rheumatology Unit, Faculty of Medicine, National University of Colombia, Cra. 30 No. 45-03, Bldg 471, 5th Floor, Office 510, Bogota, Colombia.
authors.forename: A
authors.initials: A
authors.lastname: Iglesias-Gamarra
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D001323:Autoantibodies / Q000097:blood; D003105:Colombia; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology; D011446:Prospective Studies; D011859:Radiography; D012074:Remission Induction; D012217:Rheumatoid Factor / Q000276:immunology; D012720:Severity of Illness Index
chemical_list: D018501:Antirheumatic Agents; D001323:Autoantibodies; D059811:HLA-DRB1 Chains; D010456:Peptides, Cyclic; D012217:Rheumatoid Factor; D008727:Methotrexate
keywords: Disease activity; Early onset rheumatoid arthritis; Erosions; Radiographic progression