title: Human infection with a highly pathogenic avian influenza A (H5N6) virus in Yunnan province, China.
abstract: Highly pathogenic avian influenza A H5N6 virus has caused four human infections in China. This study reports the preliminary findings of the first known human case of H5N6 in Yunnan province. The patient initially developed symptoms of sore throat and coughing on 27 January 2015. The disease rapidly progressed to severe pneumonia, multiple organ dysfunctions and acute respiratory distress syndrome and the patient died on 6 February. Virological analysis determined that the virus belonged to H5 clade 2.3.4.4 and it has obtained partial ability for mammalian adaptation and amantadine resistance. Environmental investigation found H5 in 63% of the samples including poultry faeces, tissues, cage surface swabs and sewage from local live poultry markets by real-time RT-PCR. These findings suggest that the expanding and enhancing of surveillance in both avian and humans are necessary to monitor the evolution of H5 influenza virus and to facilitate early detection of suspected cases.
authors.affiliation: a Yunnan Provincial Center for Disease Control and Prevention , Kunming , Yunnan , PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: a Yunnan Provincial Center for Disease Control and Prevention , Kunming , Yunnan , PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D001717:Birds; D002681:China; D024882:Drug Resistance, Viral; D017809:Fatal Outcome; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000302:isolation & purification; D009980:Influenza A virus / Q000302:isolation & purification*; D005585:Influenza in Birds / Q000821:virology*; D007251:Influenza, Human / Q000175:diagnosis / Q000821:virology*; D008297:Male; D011201:Poultry Diseases / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral
keywords: H5N6; Highly pathogenic avian influenza; virological analysis