title: Trace elements levels in centenarian 'dodgers'.
abstract: Trace element bioavailability can play a role in several metabolic and physiological pathways known to be altered during the aging process. We aimed to explore the association of trace elements with increased lifespan by analyzing the circulating levels of seven trace elements (Cr, Cu, Fe, Mn, Mo, Se and Zn) in a cohort of healthy centenarians or 'dodgers' (≥100 years, free of major age-related diseases) in comparison with sex-matched younger elderly controls. Centenarians showed significant lower Cu (783.7 (76.7, 1608.9) vs 962.5 (676.3, 2064.4)μg/mL, P<0.001), but higher Fe (1.3 (0.4, 4.7) vs 1.1 (0.5, 8.4)μg/mL, P=0.003) and Se (85.7 (43.0, 256.7) vs 77.8 (24.3, 143.8)ng/mL, P=0.002) values compared with elderly controls. The logistic regression analysis identified the combination of Cu and Se as significant predictor variables associated with successful aging (P=0.001), while receiver operating characteristic (ROC) analysis confirmed that Cu and Se (either alone or in combination) were independent variables associated with healthy aging. An 'improved' trace element profile (reduced Cu and elevated Se, which are involved in key physiological processes) could play a role in the resistance to disease showed by centenarian 'dodgers', and, therefore, at least partly, be involved in the healthy aging phenotype shown by these subjects. These results should be confirmed in larger cohorts of other geographic/ethnic origin and the potential cause-effect association tested in mechanistic experimental settings.
authors.affiliation: School of Medicine and Research Institute "Dr. Viña Giner", Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain; Servicio de Nefrología, Hospital Universitario y Politécnico La Fe, Valencia, Spain. Electronic address: rafael.alis@ucv.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Alis
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain; GIDFYS, European University Miguel de Cervantes, Department of Health Sciences, Valladolid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Santos-Lozano
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain; European University of Madrid, Madrid, Spain.
authors.forename: Helios
authors.initials: H
authors.lastname: Pareja-Galeano
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Fiuza-Luces
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain; Departamento de Fisiatría y Enfermería, Facultad de Ciencias de la Salud y del Deporte, Instituto Agroalimentario de Aragón- IA2 - (Universidad de Zaragoza-CITA), Zaragoza, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Garatachea
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain; European University of Madrid, Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
authors.affiliation: 2E Science, Robbio, Pavia, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Emanuele
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006262:Health; D006801:Humans; D008136:Longevity; D008297:Male; D015999:Multivariate Analysis; D012372:ROC Curve; D014131:Trace Elements / Q000097:blood*
chemical_list: D014131:Trace Elements
keywords: Aging; Copper; Lifespan; Selenium