title: Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome.
abstract: Our study investigated the frequency of interleukin-6 (IL-6) promoter polymorphism rs1800795 (-174 G>C), possible association of this polymorphism with IL-6 levels and the outcome after stroke in 95 patients with acute ischemic stroke and 268 healthy subjects. It shows a significant reduction in the frequency of G alleles in stroke patients compared to healthy controls. Carriage of G allele is not associated with stroke subtypes, the initial severity or the outcome after stroke. The -174 polymorphisms were not associated with variation in IL-6 levels post-stroke. Our results indicate that IL-6 promoter -174 polymorphisms may play a role in susceptibility to stroke, but not stroke outcome.
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, Brisbane, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Yan
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, Brisbane, Australia.
authors.forename: Greer
authors.initials: G
authors.lastname: Jm
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, Brisbane, Australia. Electronic address: p.mccombe@uq.edu.au.
authors.forename: McCombe
authors.initials: M
authors.lastname: Pa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D020521:Stroke / Q000097:blood* / Q000209:etiology / Q000235:genetics*; D055815:Young Adult
chemical_list: D015850:Interleukin-6
keywords: Acute ischemic stroke; Immunogenetics; Interleukin 6; Polymorphism