title: Catalytic stereoselective cascade reactions of quinols with trifluoromethyl ketones: direct access to CF3-containing 1,3-dioxolanes.
abstract: A general and efficient synthesis of CF3-containing 1,3-dioxolanes using Et3N-catalyzed ketalization/oxa-Michael cascade of quinols with trifluoromethyl ketones is described. The reaction works efficiently under mild reaction conditions and produces the desired products in 68%-95% yields with acceptable diastereoselectivities. In addition, the reaction proceeds smoothly to give the desired product 3a in 92% yield and with high ee (80%) in the presence of a chiral catalyst (DHQ)2PHAL.
authors.affiliation: College of Chemistry and Chemical Engineering, Shangqiu Normal University, 298 Wenhua Road, Shangqiu, Henan 476000, China. wangjingjing0918@163.com liult05@iccas.ac.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wang
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Xu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhou
authors.forename: Wen-Xian
authors.initials: WX
authors.lastname: Zhao
authors.forename: Lantao
authors.initials: L
authors.lastname: Liu