title: Surgical Management in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience.
abstract: BACKGROUND
  We have revisited prognostic outcomes and recurrence patterns in patients with gastrointestinal stromal tumors (GISTs) who underwent complete surgical resection at a single institution.
  
  
  METHODS
  Patients who underwent curative surgical treatment were divided into two groups: those with high-risk GISTs (high-risk group) and those with very low-, low-, and intermediate-risk GISTs (lower-risk group).
  
  
  RESULTS
  A total of 109 patients who underwent surgery as an initial treatment for GIST were studied. The overall 5- and 10-year survival rates after surgery were 90.3 and 71.1%, respectively. The 5-year survival rate in high-risk group patients was 88.1%, and their overall survival rate did not vary significantly from that of the lower-risk group (5-year survival rate, 91.3%). The recurrence rate in patients with high-risk GISTs gradually increased without reaching a plateau, with a cumulative rate of GIST recurrence of 26.4 and 48.9% at 5 and 10 years after surgical treatment, respectively.
  
  
  CONCLUSIONS
  Our data suggest that the repeat surgical management in metastatic GIST is of clinical usefulness whatever the risk and improves survival.
authors.affiliation: Department of Gastroenterological Surgery, Kochi University School of Medicine, Kochi City, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Tokumaru
authors.forename: Takehiro
authors.initials: T
authors.lastname: Okabayashi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shima
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shibuya
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Ozaki
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Akihito
authors.initials: A
authors.lastname: Kozuki
authors.forename: Fuminori
authors.initials: F
authors.lastname: Teraishi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakamura
authors.forename: Manabu
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Jun
authors.initials: J
authors.lastname: Iwata
authors.forename: Sojiro
authors.initials: S
authors.lastname: Morita
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Iiyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome