title: Pediatric Lupus Nephritis-Review of Literature.
abstract: Systemic lupus erythematous (SLE) is a multisystem autoimmune disorder characterized by immune dysregulation and formation of autoantibodies. A high index of suspicion is necessary to diagnose SLE. Children have more systemic involvement than adults. Kidney involvement is seen in a significant proportion of children. With advancement of therapy the survival rate of patients with SLE has significantly improved. Even then lupus nephritis is still the most important predictor of morbidity and mortality. Treatment of lupus nephritis is mostly derived from studies in adults as data on children is still lacking. Prednisolone and cyclophosphamide was the mainstay of treatment till now. Recently drugs like mycophenolate mofetil, azathioprine, rituximab are also being used in treatment of lupus nephritis with promising results and without significant adverse effects. In this review we will be discussing lupus nephritis, its diagnosis, pathogenesis, clinical picture and treatment advancements.
authors.affiliation: Department of Pediatrics, Hind Institute of Pediatrics Lucknow;. India.
authors.forename: Neha
authors.initials: N
authors.lastname: Thakur
authors.forename: Narendra
authors.initials: N
authors.lastname: Rai
authors.forename: Prerna
authors.initials: P
authors.lastname: Batra
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008181:Lupus Nephritis / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male
chemical_list: D007166:Immunosuppressive Agents
keywords: Advancements; cyclophosphamide; lupus nephritis; mofetil; mycophenolate; pediatric