title: Helicobacter pylori Infection and Dietary Factors Act Synergistically to Promote Gastric Cancer.
abstract: However, the incidence of gastric cancer (GC) has been decreased in past decades; GC is the second cause of cancer related death in the world. Evidence has illustrated that several factors including Helicobacter pylori (H. pylori) infection, host genetics, and environmental factors (smoking and particularly diet) may play a crucial role in gastric carcinogenesis. It has been demonstrated that high consumption of fresh fruits, vegetables, high level of selenium and zinc in drinking water, sufficient iron, and cholesterol protect against GC, while; smoked , pickled, and preserved foods in salt, and nitrites increase the risk of GC. Epidemiological studies have also proved that H. pylori infection and a high salt diet could independently induce atrophic gastritis and intestinal metaplasia. Recently, studies have been demonstrated that dietary factors directly influence H. pylori virulence. The use of appropriate diet could reduce levels of H. pylori colonization or virulence and prevent or delay development of peptic ulcers or gastric carcinoma. This is attractive from a number of perspectives including those of cost, treatment tolerability, and cultural acceptability. This review will describe new insights into the pathogenesis of H. pylori in relation to environmental factors, especially dietary, not only to find the developed means for preventing and treating GC, but also for understanding the role of chronic inflammation in the development of other malignancies.
authors.affiliation: Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran E-mail : bahador.behroz3@gmail.com, neginrai@yahoo.com.
authors.forename: Negin
authors.initials: N
authors.lastname: Raei
authors.forename: Bahador
authors.initials: B
authors.lastname: Behrouz
authors.forename: Saber
authors.initials: S
authors.lastname: Zahri
authors.forename: Saeid
authors.initials: S
authors.lastname: Latifi-Navid
mesh_terms: D004032:Diet / Q000009:adverse effects*; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D008679:Metaplasia / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D011230:Precancerous Conditions / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D012307:Risk Factors; D013270:Stomach / Q000382:microbiology / Q000473:pathology; D013274:Stomach Neoplasms / Q000209:etiology* / Q000382:microbiology* / Q000473:pathology