title: Optimum treatment of congenital cytomegalovirus infection.
abstract: Congenital cytomegalovirus infection affects 0.7% of live births and is the leading cause of congenital neurological handicaps of infectious origin. However, systematic screening of this infection has not been implemented in pregnancy or at birth in any country. This apparent paradox has been justified by the unavailability of an efficient vaccine and by the scarcity of data available on the treatment of congenital CMV. However, in the last decade interesting new data on the management of this congenital infection has emerged including new results on both neonatal and postnatal treatments. This review provides an update on the potential benefits of antiviral treatment and on passive immunisation both in the neonatal and the antenatal periods. These suggest a benefit to a proactive approach for neonatal and prenatal congenital infections.
authors.affiliation: a EA 73-28, Université Paris Descartes, Sorbonne Paris Cité , Paris , France.|b Laboratory of Microbiology , National Cytomegalovirus Reference Laboratory, AP-HP , Hôpital Necker-E.M. , Paris , France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
authors.affiliation: a EA 73-28, Université Paris Descartes, Sorbonne Paris Cité , Paris , France.|c Maternity, Fetal Medicine Unit, AP-HP , Hôpital Necker-E.M. , Paris , France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D058725:Peripartum Period; D011181:Postnatal Care / Q000639:trends; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000628:therapy*; D011295:Prenatal Care / Q000639:trends
chemical_list: D000998:Antiviral Agents
keywords: Cytomegalovirus; congenital; hyperimmmune globulin; valacyclovir; valganciclovir