title: Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.
abstract: A series of one-pot, sequential protocols was developed for the synthesis of novel macrocycles bearing α,β-unsaturated chemotypes. The method highlights a phosphate tether-mediated approach to establish asymmetry, and consecutive one-pot, sequential processes to access the macrocycles with minimal purification procedures. This library amenable strategy provided diverse macrocycles containing α,β-unsaturated carbon-, sulfur-, or phosphorus-based warheads.
authors.affiliation: Department of Chemistry, University of Kansas, Lawrence, Kansas 66045 (USA).
authors.forename: Salim
authors.initials: S
authors.lastname: Javed
authors.affiliation: Department of Chemistry, University of Kansas, Lawrence, Kansas 66045 (USA).
authors.forename: Mahipal
authors.initials: M
authors.lastname: Bodugam
authors.affiliation: Department of Chemistry, University of Kansas, Lawrence, Kansas 66045 (USA).
authors.forename: Jessica
authors.initials: J
authors.lastname: Torres
authors.affiliation: Department of Chemistry, University of Kansas, Lawrence, Kansas 66045 (USA).
authors.forename: Arghya
authors.initials: A
authors.lastname: Ganguly
authors.affiliation: Department of Chemistry, University of Kansas, Lawrence, Kansas 66045 (USA).
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
mesh_terms: D047029:Lactams, Macrocyclic / Q000138:chemical synthesis; D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D009282:Naphthalenesulfonates / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: D047029:Lactams, Macrocyclic; D047028:Macrocyclic Compounds; D009282:Naphthalenesulfonates; C016768:naphthosultone
keywords: heterocycles; lactams; macrocycles; one-pot reactions; phosphate-tether mediation