title: Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes.
abstract: The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China. zhangwnk@hotmail.com shengcq@hotmail.com.
authors.forename: Shanchao
authors.initials: S
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Fang
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Dong
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Zhenyuan
authors.initials: Z
authors.lastname: Miao
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Yao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Wannian
authors.initials: W
authors.lastname: Zhang
authors.forename: Chunquan
authors.initials: C
authors.lastname: Sheng