title: Genetic insights into the mechanisms of Fgf signaling.
abstract: The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required throughout embryonic and postnatal development and also regulates multiple homeostatic functions in the adult. Aberrant Fgf signaling causes many congenital disorders and underlies multiple forms of cancer. Understanding the mechanisms that govern Fgf signaling is therefore important to appreciate many aspects of Fgf biology and disease. Here we review the mechanisms of Fgf signaling by focusing on genetic strategies that enable in vivo analysis. These studies support an important role for Erk1/2 as a mediator of Fgf signaling in many biological processes but have also provided strong evidence for additional signaling pathways in transmitting Fgf signaling in vivo.
authors.affiliation: Department of Developmental and Regenerative Biology, Tisch Cancer Institute, Icahn School of Medicine at Mt. Sinai, New York, New York 10029, USA.
authors.forename: J Richard
authors.initials: JR
authors.lastname: Brewer
authors.affiliation: Department of Developmental and Regenerative Biology, Tisch Cancer Institute, Icahn School of Medicine at Mt. Sinai, New York, New York 10029, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: Mazot
authors.affiliation: Department of Developmental and Regenerative Biology, Tisch Cancer Institute, Icahn School of Medicine at Mt. Sinai, New York, New York 10029, USA.
authors.forename: Philippe
authors.initials: P
authors.lastname: Soriano
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D047108:Embryonic Development / Q000235:genetics; D004789:Enzyme Activation / Q000235:genetics; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011485:Protein Binding; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D005346:Fibroblast Growth Factors
keywords: Erk1/2; Fgfr; fibroblast growth factor; receptor tyrosine kinase; signaling