title: Progressive multifocal leukoencephalopathy masquerading as cerebellar infarction.
abstract: Progressive neurological signs and symptoms, in immunocompromised individuals, could be due to progressive multifocal leukoencephalopathy (PML). We report the case of a patient who present a stroke unit with symptoms that were consistent initially with a posterior circulation stroke. Prior chemotherapy with Rituximab, for a lymphoma, had predisposed the patient to infection with the JC virus. Physicians need to be aware of the condition, and patients need to aware of these risks of chemotherapy.
authors.affiliation: Nottingham University Hospitals NHS Trust-Stroke, Nottingham, Nottinghamshire, UK.
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Willott
authors.affiliation: Department Care of the Elderly, City Hospital, Nottingham NG5 1PB, UK.
authors.forename: Wayne
authors.initials: W
authors.lastname: Sunman
authors.affiliation: Nottingham University Hospitals-Nottingham City Hospital, Nottingham NG5 1PB, UK.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Munshi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D020520:Brain Infarction / Q000175:diagnosis*; D002526:Cerebellar Diseases / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D007577:JC Virus / Q000276:immunology / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors; D000069283:Rituximab / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D000069283:Rituximab
keywords: ataxia; brain infarction; older people; posterior circulation; progressive multifocal leukoencephalopathy; rituximab; stroke