title: Intractable Neurosarcoidosis Effectively Treated with Infliximab.
abstract: We herein describe the case of an 18-year-old girl who presented with dizziness and headache in 2012. In 2013, brain magnetic resonance imaging revealed multiple intracerebral small lesions and intracerebral hydrocephalus. She was diagnosed with neurosarcoidosis following a brain biopsy. Although prednisolone, methotrexate, and azathioprine were administered, her hydrocephalus worsened and her granulomatous lesions were observed to increase in number on MRI. The patient's hydrocephalus showed no improvement despite her undergoing one ventriculoperitoneal shunt procedure, one septum pellucidum fenestration, and three ventriculoatrial shunt procedures. Infliximab therapy was then initiated, which resulted in a reduction in the size of the granulomatous lesions and the improvement of the patient's clinical symptoms. Infliximab may be a viable therapeutic option for treating intractable neurosarcoidosis.
authors.affiliation: Department of Neurology, Saitama Medical University International Medical Center, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Sano
authors.forename: Ichiro
authors.initials: I
authors.lastname: Deguchi
authors.forename: Takuya
authors.initials: T
authors.lastname: Fukuoka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Uchino
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Adachi
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuda
authors.forename: Masaki
authors.initials: M
authors.lastname: Takao
authors.forename: Norio
authors.initials: N
authors.lastname: Tanahashi
mesh_terms: D000293:Adolescent; D002493:Central Nervous System Diseases / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000628:therapy; D000069285:Infliximab / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D012507:Sarcoidosis / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000069285:Infliximab