title: An ultrasensitive and incubation-free electrochemical immunosensor using a gold-nanocatalyst label mediating outer-sphere-reaction-philic and inner-sphere-reaction-philic species.
abstract: This communication reports a new nanocatalytic scheme based on the facts that the redox reaction between a highly outer-sphere-reaction-philic (OSR-philic) species and a highly inner-sphere-reaction-philic (ISR-philic) species is slow and that an OSR- and ISR-philic Au-nanocatalyst label can mediate the two different types of redox species. This scheme allows highly sensitive and incubation free detection of creatine kinase-MB.
authors.affiliation: Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea. hyang@pusan.ac.kr.
authors.forename: Chiew San
authors.initials: CS
authors.lastname: Fang
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Oh
authors.forename: Aram
authors.initials: A
authors.lastname: Oh
authors.forename: Kwangyeol
authors.initials: K
authors.lastname: Lee
authors.forename: Seonhwa
authors.initials: S
authors.lastname: Park
authors.forename: Sinyoung
authors.initials: S
authors.lastname: Kim
authors.forename: Jin Kyoon
authors.initials: JK
authors.lastname: Park
authors.forename: Haesik
authors.initials: H
authors.lastname: Yang
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002384:Catalysis; D052279:Creatine Kinase, MB Form / Q000097:blood; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D007074:Immunoglobulin G / Q000097:blood; D057230:Limit of Detection; D051379:Mice; D053758:Nanoparticles; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D017971:Tin Compounds
chemical_list: D006834:Hydrazines; D007074:Immunoglobulin G; D009942:Organometallic Compounds; D017971:Tin Compounds; C029424:hydrazine; D015082:2,2'-Dipyridyl; C109984:indium tin oxide; D006046:Gold; C085573:osmium bis(2,2'-bipyridine)chloride; D052279:Creatine Kinase, MB Form