title: An optimal hydrogen-bond surrogate for α-helices.
abstract: Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.
authors.affiliation: Department of Chemistry, New York University, New York, NY 10003, USA. arora@nyu.edu.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Joy
authors.affiliation: Department of Chemistry, New York University, New York, NY 10003, USA. arora@nyu.edu.
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora
mesh_terms: D006860:Hydrogen Bonding; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D010455:Peptides