title: Graphene oxide-fullerene C60(GO-C60) hybrid for photodynamic and photothermal therapy triggered by near-infrared light.
abstract: Photodynamic therapy (PDT) and photothermal therapy (PTT) are two promising methodologies for cancer therapy. Although a variety of materials which can be used in PDT and PTT have been developed in the past decades, those showing the combined effect of PDT and PTT under NIR irradiation are rare. Graphene oxide (GO) and fullerene C60(denoted as C60hereafter) with unique physical and chemical properties are promising candidates for PTT and PDT, respectively. Here, by using a stepwise conjugation method, a new GO-C60hybrid which contains hydrophilic methoxypolyethylene glycol (mPEG) and mono-substituted C60was constructed for combined PDT and PTT. The hybrid shows good solubility in different environments including physiological solutions. The introduction of C60to GO did not decrease the photothermal properties of GO, while the conjugation of GO to C60activated the ability of C60to generate singlet oxygen (1O2) in near infrared (NIR) region in aqueous solution. The GO-C60hybrid also shows good ability to induce the generation of reactive oxygen species (ROS) in Hela cells. Due to the synergistic effect between GO and C60, GO-C60hybrid exhibits superior performance in the inhibition of cancer cells compared to both individuals, indicating its high potential in practical applications.
authors.affiliation: State Key Laboratory of Solid Lubrication & Laboratory of Clean Energy Chemistry and Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.affiliation: State Key Laboratory of Solid Lubrication & Laboratory of Clean Energy Chemistry and Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. Electronic address: hgli@licp.cas.cn.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, China. Electronic address: liucg@ouc.edu.cn.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Liu
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D006108:Graphite / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D037741:Fullerenes; D010087:Oxides; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D011092:Polyethylene Glycols; D006108:Graphite; C028210:monomethoxypolyethylene glycol; C069837:fullerene C60
keywords: Fullerene (C(60)); Graphene oxide; NIR; Photodynamic therapy; Photothermal therapy