title: Anthropometric Indices in Children With Refractory Epilepsy.
abstract: OBJECTIVE
  We aimed to assess the effect of body mass index (BMI) on reducing the risk of refractory seizure due to lipoid tissue factors.
  
  
  METHODS
  This matched case-control study, consisted of cases (Patients with refractory epilepsy) and controls (Healthy children) referred to 17 Shahrivar Hospital, Guilan University of Medical Sciences, Guilan, Iran during 2013-2014. Data were gathered by a form including demographic characteristics, type of epilepsy, predominant time of epilepsy, therapeutic approach, frequency of epilepsy, time of disease onset and anthropometric indices. We measured anthropometric indices and transformed them into Z-scores. Data were reported by descriptive statistics (mean and standard deviation) and analyzed by Pearson correlation coefficient, paired t test and multinomial regression analysis test using SPSS 19.
  
  
  RESULTS
  There was no significant difference between sex groups regarding anthropometric indices. Generalized and focal types of epilepsies were noted on 57.5% and 38.75% of patients, respectively. Daytime epilepsies happened in 46.25% of patients and 33.75% noted no predominant time for epilepsies. Clinicians indicated poly-therapy for the majority of patients (92.5%). The most common onset times for epilepsies were 36-72 months for 32.5% of patients. Lower onset time indicated lower frequency of refractory epilepsies. Although, there was significant difference between Zheight and predominant time of epilepsies but no significant relation was found between types of epilepsies and frequency of epilepsies with anthropometric indices. Using multivariate regression analysis by backward LR, Zweight and birth weight were noted as the predicting factors of refractory epilepsies.
  
  
  CONCLUSIONS
  This effect may be because of leptin. Therefore, researchers recommend further investigations regarding this issue in children with epilepsy.
authors.affiliation: Pediatric Growth Disorders Research Center, 17 Th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran ; Department of Pediatrics Neurology, 17th Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Aminzadeh
authors.affiliation: Pediatric Growth Disorders Research Center, 17 Th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran ; Department of Pediatrics Endocrinology And Metabolism, 17th Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Setila
authors.initials: S
authors.lastname: Dalili
authors.affiliation: Pediatric Growth Disorders Research Center, 17 Th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Yalda
authors.initials: Y
authors.lastname: Ashoorian
authors.affiliation: Pediatric Growth Disorders Research Center, 17 Th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran ; Department of Pediatrics Endocrinology And Metabolism, 17th Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Shahin
authors.initials: S
authors.lastname: Kohmanaee
authors.affiliation: Pediatric Growth Disorders Research Center, 17 Th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Afagh
authors.initials: A
authors.lastname: Hassanzadeh Rad
keywords: Anthropometric indices; Children; Epilepsy; Obesity