title: Occupational Exposure to Pesticides With Occupational Sun Exposure Increases the Risk for Cutaneous Melanoma.
abstract: OBJECTIVE
  The objective of the study was to examine the association between occupational exposure to pesticides and cutaneous melanoma, controlling for all possible confounders.
  
  
  METHODS
  A pooled analysis of two case-control studies was conducted in two different geographic areas (Italy and Brazil). Detailed pesticides exposure histories were obtained.
  
  
  RESULTS
  Ever use of any pesticide was associated with a high risk of cutaneous melanoma (odds ratio 2.58; 95% confidence interval 1.18-5.65) in particular exposure to herbicides (glyphosate) and fungicides (mancozeb, maneb), after controlling for confounding factors. When subjects were exposed to both pesticides and occupational sun exposure, the risk increased even more (odds ratio 4.68; 95% confidence interval 1.29-17.0).
  
  
  CONCLUSIONS
  The study suggests an augmented risk of cutaneous melanoma among subjects with exposure to pesticides, in particular among those exposed to occupational sun exposure.
authors.affiliation: Epidemiology Unit, Istituto Dermopatico dell'Immacolata, IDI- IRCCS-FLMM, Rome, Italy (Fortes, Mastroeni); Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Brazil (Segatto M, Hohmann B, Bonamigo); Occupational and Environmental Epidemiology Unit, ISPO Cancer Prevention and Research, Institute, Florence, Italy (Miligi); Dermatology Service, Federal University of Health Sciences of Porto Alegre (Bonamigo); and Dermatology Service, Federal University of Rio Grande do Sul, Porto Alegre, Brazil (Bakos).
authors.forename: Cristina
authors.initials: C
authors.lastname: Fortes
authors.forename: Simona
authors.initials: S
authors.lastname: Mastroeni
authors.forename: Marjorie
authors.initials: M
authors.lastname: Segatto M
authors.forename: Clarissa
authors.initials: C
authors.lastname: Hohmann
authors.forename: Lucia
authors.initials: L
authors.lastname: Miligi
authors.forename: Lucio
authors.initials: L
authors.lastname: Bakos
authors.forename: Renan
authors.initials: R
authors.lastname: Bonamigo
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity; D005998:Glycine / Q000031:analogs & derivatives / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008344:Maneb / Q000633:toxicity; D008545:Melanoma / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D010575:Pesticides / Q000633:toxicity*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology; D013472:Sunlight / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D055815:Young Adult; D015038:Zineb / Q000633:toxicity; D000097797:Glyphosate
chemical_list: D005659:Fungicides, Industrial; D005998:Glycine; D006540:Herbicides; D008344:Maneb; D010575:Pesticides; D015038:Zineb; D000097797:Glyphosate; C013099:mancozeb