title: Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma.
abstract: Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with β2-AR expression was verified by the chi-square test or Fischer's exact test. To verify the correlation of β2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson's correlation coefficient test was applied. Results. The expression of β2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (r = 0.383; p = 0.002). The immunohistochemical distribution of β2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p = 0.038), simultaneous alcohol and tobacco consumption (p = 0.010), and T stage (p = 0.014). Conclusions. The correlation of β2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive.
authors.affiliation: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil.
authors.forename: Denise Tostes
authors.identifier: 0000-0001-6163-5526
authors.initials: DT
authors.lastname: Oliveira
authors.affiliation: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil.
authors.forename: Diego Mauricio
authors.initials: DM
authors.lastname: Bravo-Calderón
authors.affiliation: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil.
authors.forename: Gustavo Amaral
authors.initials: GA
authors.lastname: Lauand
authors.affiliation: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil.
authors.forename: Agnes
authors.initials: A
authors.lastname: Assao
authors.affiliation: Department of Pathology and Forensic Sciences, University Hospital and School of Medicine of Santiago de Compostela, Santiago de Compostela, 15706 Galicia, Spain.
authors.forename: José-Manuel
authors.initials: JM
authors.lastname: Suárez-Peñaranda
authors.affiliation: Faculty of Medicine and Dentistry, Institute of Research of Santiago de Compostela (IDIS), Clinical Hospital University of Santiago, Santiago de Compostela, 15782 A Coruña, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Pérez-Sayáns
authors.affiliation: Faculty of Medicine and Dentistry, Institute of Research of Santiago de Compostela (IDIS), Clinical Hospital University of Santiago, Santiago de Compostela, 15782 A Coruña, Spain.
authors.forename: Abel
authors.initials: A
authors.lastname: García-García
authors.affiliation: Department of Computing, Faculty of Sciences, São Paulo State University (UNESP), 17033-360 Bauru, SP, Brazil.
authors.forename: Aparecido Nilceu
authors.initials: AN
authors.lastname: Marana
authors.affiliation: Pathology Division, Adolfo Lutz Institute, 01246-902 São Paulo, SP, Brazil.
authors.forename: Suely
authors.initials: S
authors.lastname: Nonogaki
authors.affiliation: Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil.
authors.forename: José Roberto Pereira
authors.initials: JR
authors.lastname: Lauris
authors.affiliation: Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, 01509-010 São Paulo, SP, Brazil.
authors.forename: Luiz Paulo
authors.initials: LP
authors.lastname: Kowalski