title: The Effect of Preimplantation Genetic Screening on Implantation Rate in Women over 35 Years of Age.
abstract: OBJECTIVE
  Advanced maternal age (AMA) is an important factor in decreasing success of assisted reproductive technology by having a negative effect on the success rate of intra-cytoplasmic sperm injection (ICSI), particularly by increasing the rate of embryo aneuploidy. It has been suggested that the transfer of euploid embryos increases the implantation and pregnancy rates, and decreases the abortion rate. Preimplantation genetic screening (PGS) is a method for selection of euploid embryos. Past studies, however, have reported different results on the success of pregnancy after PGS in AMA. Investigating the pregnancy rate of ICSI with and without PGS in female partners over 35 years of age referred to infertility centers in Tehran.
  
  
  METHODS
  In this randomized controlled trial, 150 couples with the female partner over age of 35 were included. Fifty couples underwent PGS and the remaining were used as the control group. PGS was carried out using fluorescent in situ hybridization (FISH) for chromosomes 13, 18, 21, X and Y. Results of embryo transfer following PGS were evaluated and compared with those in the control group.
  
  
  RESULTS
  Implantation rates obtained in the PGS and control groups were 30 and 32% respectively and not significantly different (P>0.05).
  
  
  CONCLUSIONS
  PGS for chromosomes 13, 18, 21, X and Y does not increase implantation rate in women over 35 years of age and therefore the regular use of PGS in AMA is not recommended.
authors.affiliation: Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Moayeri
authors.affiliation: Omid Infertility Clinic, Tehran, Iran.
authors.forename: Hojatolah
authors.initials: H
authors.lastname: Saeidi
authors.affiliation: Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Modarresi
authors.affiliation: Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hashemi
keywords: Aneuploidies; FISH Technique; ICSI; Maternal Age; Preimplantation Genetic Screening