title: [Treatment and outcome of recurrent cervical lymph nodes in patients with nasopharyngeal carcinoma after radiotherapy].
abstract: OBJECTIVE
  To evaluate the efficacies of different treatments for recurrent cervical lymph nodes and the factors contributing to prognosis in patients with nasopharyngeal carcinoma after radiotherapy.
  
  
  METHODS
  Clinical data of 79 patients with nasopharyngeal carcinoma after radiotherapy were retrospectively analyzed, and all cases were diagnosed as having recurrent cervical lymph nodes by pathological examination. The factors including sex, age, the interval between completion of radiotherapy and recurrence, rN stage, treatment methods, and the location relationship between recurrent lesion and primary tumor in the neck were analyzed for prognosis. Kaplan-Meier curves, Log-rank test and Cox's proportional hazards regression mode were used in the statistical analysis.
  
  
  RESULTS
  The median recurrence time was 26 months, and the 1- , 3- and 5-year overall survival rates were 77.9%, 53.4% and 39.7%. Cox's proportional hazards regression mode analysis indicated that age, rN stage, treatment methods, and the location relationship between recurrent lesion and primary tumor were significantly prognostic factors.
  
  
  CONCLUSIONS
  Neck dissection is superior to re-radiotherapy in treatment of recurrent cervical lymph nodes in nasopharyngeal carcinoma after radiotherapy. The patients younger than 45 years old, in early rN stage and for recurrence in the center region of primary tumor have a better prognosis.
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Lan
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Si
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Zhuoxia
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Jinjie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Jingjin
authors.initials: J
authors.lastname: Weng
authors.affiliation: Department of Otolaryngology Head and Neck Tumor, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
authors.forename: Fuling
authors.initials: F
authors.lastname: Zhou
mesh_terms: D002277:Carcinoma; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D009333:Neck; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome