title: Renal inflammatory and oxidative and metabolic changes after 6 weeks of cafeteria diet in rats.
abstract: BACKGROUND
  Obesity is a disease in which inflammation is directly involved and can lead to impaired renal function.
  
  
  OBJECTIVE
  To evaluate the influence of short term exposure to cafeteria diet on kidney tissue inflammation and advanced glycation end products (AGEs) in the rat plasma.
  
  
  METHODS
  Male Wistar rats (10 weeks of age, weighing 350 g) were assigned to receive commercial chow diet (C; n = 8 animals/group, 5% of energy from fat) or cafeteria diet (CAF-D, n = 8 animals/group: 29% energy fat) and sucrose in drinking water (300 g/L) for 6 weeks.
  
  
  RESULTS
  adiposity index at six weeks was higher in CAF-D group compared to C. The same behavior was observed for plasma levels of glucose, triglycerides, leptin, insulin and AGEs. The gene expression of IL-6 and TNF-α in renal tissue was higher in CAF-D group and no significant difference in adipose tissue. There was no increase of these cytokines in plasma and kidney or histologically. There was a significant decrease of adiponectin in the CAF-D group.
  
  
  CONCLUSIONS
  The short exposure CAF-D reflects changes in metabolism, increased plasma levels of AGEs, which may reflect the increased expression of inflammatory cytokines in the kidney.
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Maria Eugênia Lopes
authors.initials: ME
authors.lastname: Navarro
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Klinsmann Carolo Dos
authors.initials: KC
authors.lastname: Santos
authors.affiliation: Universidade Federal de Mato Grosso, Brazil.
authors.forename: André Ferreira do
authors.initials: AF
authors.lastname: Nascimento
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Fabiane Valentini
authors.initials: FV
authors.lastname: Francisqueti
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Igor Otávio
authors.initials: IO
authors.lastname: Minatel
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Damiana Tortolero
authors.initials: DT
authors.lastname: Pierine
authors.affiliation: Universidade Federal de Mato Grosso, Brazil.
authors.forename: Renata Azevedo de Melo
authors.initials: RA
authors.lastname: Luvizotto
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Ana Lúcia A
authors.initials: AL
authors.lastname: Ferreira
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Dijon Henrique Salomé de
authors.initials: DH
authors.lastname: Campos
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Camila Renata
authors.initials: CR
authors.lastname: Corrêa
mesh_terms: D050154:Adiposity; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004032:Diet / Q000009:adverse effects*; D017127:Glycation End Products, Advanced / Q000097:blood*; D007249:Inflammation / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016207:Cytokines; D017127:Glycation End Products, Advanced