title: Breaking bad habits: Targeting MDSCs to alleviate immunosuppression in prostate cancer.
abstract: The myeloid-derived suppressor cells (MDSCs) contribute to tumor immune evasion and still remain an elusive therapeutic target. Our study identified granulocytic MDSCs accumulating in prostate cancer patients during disease progression. We demonstrate the feasibility of using STAT3siRNA-based strategy for targeting MDSCs to alleviate arginase-dependent suppression of T cell activity.
authors.affiliation: Department of Cancer Immunotherapeutics & Tumor Immunology at Beckman Research Institute, City of Hope National Medical Center , Duarte, CA, USA.
authors.forename: Sumanta K
authors.initials: SK
authors.lastname: Pal
authors.affiliation: Department of Medical Oncology & Experimental Therapeutics, City of Hope National Medical Center , Duarte, CA, USA.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kortylewski
keywords: Arginase; MDSC; STAT3; TLR9; immunotherapy; myeloid-derived suppressor cells; prostate cancer