title: The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis.
abstract: BACKGROUND
  In implant dentistry, bone substitute materials and barrier membranes are used in different treatments including guided bone regeneration (GBR), socket preservation, alveolar ridge augmentation, maxillary sinus elevation, and filling bony defects around the inserted dental implant. One of the most important factors in prognosis of treatments using these materials is the growth of new blood vessels in applied areas. Present review was performed to evaluate the effect of the bone-grafting and barrier membrane materials on angiogenesis events.
  
  
  METHODS
  An electronic search was performed in PubMed, MEDLINE, and EMBASE databases via OVID using the keywords mentioned in the PubMed and MeSH headings regarding the role of angiogenesis in implant dentistry from January 2000-April 2014.
  
  
  RESULTS
  Of the 5,622 articles identified in our initial search results, only 33 met the inclusion criteria set for this review. Among bone substitute materials the autogenous bone-grafts, and among the barrier membranes the collagenous membranes, had the highest angiogenic potentials. Other bone-grafting materials or membranes were mostly used with pro-angiogenic factors to enhance their angiogenic properties.
  
  
  CONCLUSIONS
  Angiogenesis is one of the key factors, which plays a critical role in success rate of GBR technique and is seriously considered in manufacturing bone-grafting and barrier membrane materials. However, there is still lack of clinical and in-vivo studies addressing the effect of angiogenesis in treatments using bone-grafting and barrier membrane materials.
authors.affiliation: Departments of Ophthalmology &, Visual Sciences and Biomedical Engineering, University of Wisconsin School of Medicine, and Public health, Madison, WI, USA, Saghiri@wisc.edu.
authors.forename: M-A
authors.initials: MA
authors.lastname: Saghiri
authors.forename: A
authors.initials: A
authors.lastname: Asatourian
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Godoy
authors.forename: N
authors.initials: N
authors.lastname: Sheibani
mesh_terms: D000540:Alveolar Ridge Augmentation; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D006801:Humans; D008443:Maxillary Sinus; D018919:Neovascularization, Physiologic
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants