title: The relationship between cardiac hemodynamics and exercise tolerance in cystic fibrosis.
abstract: Individuals with cystic fibrosis (CF) have reduced pulmonary function and exercise tolerance. Additionally, these individuals may develop abnormal cardiac function. The implications of abnormal cardiac function on exercise tolerance are unclear in CF.
  
  
  
  Study relationships between exercise cardiac hemodynamics and exercise tolerance in CF.
  
  
  
  17 CF and 25 controls participated in cardiopulmonary exercise testing to measure exercise duration and peak workload (PW). Cardiac index (QI) was measured using acetylene rebreathe and oxygen uptake (VO2) breath-by-breath. Forced expiratory volume in 1-second (FEV1) was performed at rest.
  
  
  
  Peak QI was 6.7 ± 0.5 vs. 9.1 ± 0.3 mL/min/m(2), CF vs. controls, respectively (P < 0.05). Linear regressions between QI (R(2) = 0.63 and 0.51) and exercise duration or PW were stronger than VO2 (R(2) = 0.35 and 0.37) or FEV1 (R(2) = 0.34 and 0.36) in CF, respectively (P < 0.05).
  
  
  
  These data are clinically relevant suggesting attenuated cardiac function in addition to low airway function relate to exercise tolerance in CF.
authors.affiliation: Department of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; School of Kinesiology, University of Minnesota, Cooke Hall, 1900 University Ave. SE. Minneapolis, MN 55455, USA. Electronic address: vaniterson.erik@mayo.edu.
authors.forename: Erik H
authors.initials: EH
authors.lastname: Van Iterson
authors.affiliation: Department of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; College of Pharmacy, University of Arizona, 1295 N Martin Ave., Tucson, AZ 85721, USA.
authors.forename: Courtney M
authors.initials: CM
authors.lastname: Wheatley
authors.affiliation: College of Pharmacy, University of Arizona, 1295 N Martin Ave., Tucson, AZ 85721, USA; Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Baker
authors.affiliation: Department of Pediatrics, University of Arizona, 1501 N. Campbell Ave., Room 3301, Tucson, AZ 85724, USA.
authors.forename: Wayne J
authors.initials: WJ
authors.lastname: Morgan
authors.affiliation: School of Kinesiology, University of Minnesota, Cooke Hall, 1900 University Ave. SE. Minneapolis, MN 55455, USA; College of Pharmacy, University of Arizona, 1295 N Martin Ave., Tucson, AZ 85721, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Snyder
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000503:physiopathology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D012129:Respiratory Function Tests; D055815:Young Adult
keywords: CFTR; Cardiac output; Cardiopulmonary exercise test; Exercise capacity; Functional limitation; Pulmonary function; Stroke volume