title: Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens.
abstract: The palladium-catalyzed ortho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method used.
authors.affiliation: School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, U.K.
authors.forename: Robin B
authors.initials: RB
authors.lastname: Bedford
authors.affiliation: School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, U.K.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Brenner
authors.affiliation: Vertex Pharmaceuticals Ltd. (Europe), 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, U.K.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Durrant
authors.affiliation: School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, U.K.
authors.forename: Timothy
authors.initials: T
authors.lastname: Gallagher
authors.affiliation: School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, U.K.
authors.forename: Carolina
authors.initials: C
authors.lastname: Méndez-Gálvez
authors.affiliation: School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, U.K.
authors.forename: Michelle
authors.initials: M
authors.lastname: Montgomery
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D004964:Estriol / Q000737:chemistry*; D004967:Estrogens / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002219:Carbamates; D004967:Estrogens; D010165:Palladium; D004964:Estriol