title: Efficacy and Safety of Minoxidil 5% Foam in Combination With a Botanical Hair Solution in Men With Androgenic Alopecia.
abstract: Androgenic alopecia (AGA) is the most common type of hair loss in men, characterized by hair miniaturization, hairline recession, and vertex balding. It affects approximately 50% of men, negatively affecting self-esteem and sociability. Topical minoxidil formulations are approved up to a 5% concentration for men, but patient adherence to treatment is challenged by gradual results that may be perceived as a lack of initial benefit. Herbal extracts, which are also believed to promote healthier-looking hair, have a long history of use in hair care formulations. The safety and efficacy of a twice-daily regimen of 5% minoxidil foam used in combination with a novel botanical hair solution was evaluated in a 12-week, multicenter, single-arm, open label study in 56 subjects with mild to moderate AGA. Assessments included investigator ratings of improvement and subject self-ratings of satisfaction. Investigator ratings indicated significant improvement in scalp hair coverage and perception of overall treatment benefit in as early as 4 weeks (P<.001). Subject self-ratings were significant for improved hair growth and hair appearance in as few as 4 weeks (P<.05). The regimen was well tolerated, and subjects indicated a high degree of satisfaction. Investigator and subject-assessed efficacy and subject satisfaction with this novel regimen provide clinicians with an effective treatment option for AGA that also provides a high level of patient satisfaction, which may help promote patient adherence to long-term treatment.
authors.forename: Terrence C
authors.initials: TC
authors.lastname: Keaney
authors.forename: Hanh
authors.initials: H
authors.lastname: Pham
authors.forename: Erika
authors.initials: E
authors.lastname: von Grote
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Meckfessel
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000505:Alopecia / Q000175:diagnosis* / Q000188:drug therapy*; D004339:Drug Compounding; D004359:Drug Therapy, Combination; D006203:Hair Preparations / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000008:administration & dosage* / Q000737:chemistry; D017060:Patient Satisfaction; D019999:Pharmaceutical Solutions / Q000008:administration & dosage / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006203:Hair Preparations; D019999:Pharmaceutical Solutions; D010936:Plant Extracts; D008914:Minoxidil