title: Influence of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1-T2 magnetic resonance imaging performance.
abstract: Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) coated with polyacrylic acid (PAA) were synthesized by a hydrothermal method in gram-scale quantity and extensively characterized. Only the nanoparticles subjected to an additional centrifugation step showed narrow size distribution, high polymeric coverage, and ideal superparamagnetism. In addition to improved physico-chemical properties, these nanoparticles feature high stability in vitro as well as dual T1-T2 performance as contrast agents (CAs) for magnetic resonance imaging (MRI), highlighting the importance of the additional separation step in obtaining material with the desired properties.
authors.affiliation: International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal; Department of Applied Physics, Technological Research Institute, Nanotechnology and Magnetism Lab, Universidade de Santiago de Compostela, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Guldris
authors.affiliation: Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Spain.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Argibay
authors.affiliation: International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.
authors.forename: Yury V
authors.initials: YV
authors.lastname: Kolen'ko
authors.affiliation: International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.
authors.forename: Enrique
authors.initials: E
authors.lastname: Carbó-Argibay
authors.affiliation: Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Spain.
authors.forename: Tomás
authors.initials: T
authors.lastname: Sobrino
authors.affiliation: Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Campos
authors.affiliation: International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Salonen
authors.affiliation: International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.
authors.forename: Manuel
authors.initials: M
authors.lastname: Bañobre-López
authors.affiliation: Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Castillo
authors.affiliation: International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal; Department of Applied Physics, Technological Research Institute, Nanotechnology and Magnetism Lab, Universidade de Santiago de Compostela, Spain. Electronic address: jose.rivas@usc.es.
authors.forename: José
authors.initials: J
authors.lastname: Rivas
keywords: Contrast agent; Magnetic resonance imaging; Physico-chemical properties; Protein adsorption; Superparamagnetic iron oxide nanoparticles; T(1)–T(2) contrast