title: The Impact of 3:1 Ketogenic Diet on Cardiac Repolarization Changes in Children with Refractory Seizures: A Prospective Follow-Up Study.
abstract: Background The association between ketogenic diet (KD) and prolonged QT interval, life-threatening ventricular arrhythmias, and sudden death is controversial. Aim We aimed to prospectively evaluate the effect of KD on electrocardiography (ECG) measures in children with refractory epilepsy. Method A total of 70 children with drug-resistant epilepsy who received a KD for at least 12 months were included in the study. The standard 12-lead electrocardiography was performed in all patients before the beginning and in the 12th month of KD. Heart rate, P-wave duration and dispersion, corrected QT interval and QT dispersion, and Tp-e interval were measured. Results All ECG-derived parameters, but P-wave dispersion increased after 12 months of KD compared with the baseline values. However, these changes were not statistically significant. Conclusion A 12-month long 3:1 KD treatment exerts no deleterious effect on cardiac repolarization measures.
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Özdemir
authors.affiliation: Department of Pediatric Neurology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Orkide
authors.initials: O
authors.lastname: Güzel
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Küçük
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Karadeniz
authors.affiliation: Department of Pediatric Neurology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Ünsal
authors.initials: Ü
authors.lastname: Yılmaz
authors.affiliation: Department of Pediatrics, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Tansel
authors.initials: T
authors.lastname: Calik
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Meşe
mesh_terms: D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002239:Carbohydrate Metabolism, Inborn Errors / Q000150:complications; D002648:Child; D002675:Child, Preschool; D055423:Diet, Ketogenic / Q000009:adverse effects*; D000069279:Drug Resistant Epilepsy / Q000178:diet therapy* / Q000209:etiology; D004562:Electrocardiography; D004831:Epilepsies, Myoclonic / Q000178:diet therapy; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications; D007223:Infant; D018887:Landau-Kleffner Syndrome / Q000150:complications; D065768:Lennox Gastaut Syndrome / Q000178:diet therapy; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications; D009004:Monosaccharide Transport Proteins / Q000172:deficiency; D011446:Prospective Studies; D013036:Spasms, Infantile / Q000178:diet therapy; D013226:Status Epilepticus / Q000178:diet therapy; D014402:Tuberous Sclerosis / Q000150:complications; D055815:Young Adult
chemical_list: D009004:Monosaccharide Transport Proteins