title: Dendritic cell development-History, advances, and open questions.
abstract: Dendritic cells (DCs) are uniquely potent in orchestrating T cell immune response, thus they are indispensable immune sentinels. They originate from progenitors in the bone marrow through hematopoiesis, a highly regulated developmental process involving multiple cellular and molecular events. This review highlights studies of DC development-from the discovery of DCs as glass-adherent antigen presenting cells to the debate and resolution of their origin and lineage map. In particular, we summarize the roles of lineage-specific cytokines, the placement of distinct hematopoietic progenitors within the DC lineage and transcriptional programs governing DC development, which together have allowed us to diagram the current view of DC hematopoiesis. Important open questions and debates on the DC development and relevant models are also discussed.
authors.affiliation: Columbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: sp2911@cumc.columbia.edu.
authors.forename: Sarah
authors.initials: S
authors.lastname: Puhr
authors.affiliation: Columbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: jl3567@cumc.columbia.edu.
authors.forename: Jaeyop
authors.initials: J
authors.lastname: Lee
authors.affiliation: Columbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: ez2229@cumc.columbia.edu.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Zvezdova
authors.affiliation: Columbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA.
authors.forename: Yu J
authors.initials: YJ
authors.lastname: Zhou
authors.affiliation: Columbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: kl2529@cumc.columbia.edu.
authors.forename: Kang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D006410:Hematopoiesis; D006801:Humans
keywords: CDP; Cytokine; Dendritic cell; Hematopoiesis; Lineage; MDP; Mononuclear phagocyte system; Pre-cDC; Progenitor; Transcription factor