title: Association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk in a Chinese population.
abstract: The association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk has not been investigated. In this hospital-based case-control study, we analyzed 256 patients with cervical cancer and 250 healthy controls. Pearson chi-square test was used to examine differences in the distribution of genotypes between cases and controls. Association between the polymorphism and the susceptibility to cervical cancer was evaluated using unconditional logistic regression analysis. This revealed that the frequencies of the three genotypes (CC, CT, and TT) in cervical cancer cases and controls were 17.58, 65.23, and 17.19% and 24.80, 40.40, and 34.80%, respectively; the difference between the two groups was significant (P < 0.001). We found that the CT genotype was significantly associated with increased cervical cancer risk (adjusted OR = 2.18; 95%CI = 1.37-6.11; P = 0.009). Moreover, there was significant association between PD-1.5 C/T polymorphism and susceptibility to cervical cancer under dominant model (OR = 1.27, 95%CI = 1.01-2.15, P = 0.047). We conclude that the PD-1.5 C/T polymorphism may be associated with increased risk of cervical cancer. The study also highlights the importance of conducting genetic association studies in different ethnic populations.
authors.affiliation: Department of Gynecology, Weifang Traditional Chinese Hospital, Wei Fang, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Weifang Maternity and Child Care Hospital, Wei Fang, China.
authors.forename: X Q
authors.initials: XQ
authors.lastname: Jiang
authors.affiliation: Department of Obstetrics and Gynecology, Hanting District People's Hospital of Weifang, Wei Fang, China.
authors.forename: J W
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: Department of Gynecology, Weifang Traditional Chinese Hospital, Wei Fang, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jia
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D061026:Programmed Cell Death 1 Receptor / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor