title: Multiple functions of the histone chaperone Jun dimerization protein 2.
abstract: The Jun dimerization protein 2 (JDP2) is part of the family of stress-responsible transcription factors such as the activation protein-1, and binds the 12-O-tetradecanoylphorbol-13-acetateresponse element and the cAMP response element. It also plays a role as a histone chaperone and participates in diverse processes, such as cell-cycle arrest, cell differentiation, apoptosis, senescence, and metastatic spread, and functions as an oncogene and anti-oncogene, and as a cellular reprogramming factor. However, the molecular mechanisms underlying these multiple functions of JDP2 have not been clarified. This review summarizes the structure and function of JDP2, highlighting the specific role of JDP2 in cellular-stress regulation and prevention.
authors.affiliation: Graduated Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Ming-Ho
authors.initials: MH
authors.lastname: Tsai
authors.affiliation: Graduated Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Kenly
authors.initials: K
authors.lastname: Wuputra
authors.affiliation: School of Dentistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Yin-Chu
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Graduated Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: Chang-Shen
authors.initials: CS
authors.lastname: Lin
authors.affiliation: Graduated Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Science and Engineering, Tokushima Bunri University, Sanuki, Japan; Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: Kazu@kmu.edu.tw.
authors.forename: Kazunari K
authors.initials: KK
authors.lastname: Yokoyama
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D065150:Cellular Reprogramming / Q000235:genetics; D005786:Gene Expression Regulation; D056488:Histone Chaperones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D056488:Histone Chaperones; D017382:Reactive Oxygen Species; D012097:Repressor Proteins
keywords: AP-1 repressor; ARE; Function; Histone chaperone; JDP2; ROS; Structure