title: Cognitive-Enhancing Herbal Formulae in Korean Medicine: Identification of Candidates by Text Mining and Literature Review.
abstract: OBJECTIVE
  The main aims of this study were to identify candidates for cognitive-enhancing herbal formulae from the Korean medicine literature and to obtain preliminary data that experimental and clinical researchers could use to develop new cognitive-enhancing drugs.
  
  
  METHODS
  The authors systematically searched for terms related to cognitive enhancement in Dongui Bogam (or Dongyi Baojian), a seminal Korean medicine book. They also reviewed the existing literature on the effects of candidates for cognitive-enhancing herbal formulae and their main constituents.
  
  
  CONCLUSIONS
  Twenty-three candidates were selected for cognitive-enhancing herbal formulae and their main constituents. For 14 herbal formulae among the 23 candidates, on average 5.6 published research papers per herbal formula describing cognitive-enhancing effects were found. In addition, some published papers were identified for 5 main constituents most frequently used to make up the 23 candidates.
authors.affiliation: 1 Division of Humanities and Social Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.
authors.forename: Seung Bin
authors.initials: SB
authors.lastname: Pae
authors.affiliation: 1 Division of Humanities and Social Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.
authors.forename: Byeong Cheol
authors.initials: BC
authors.lastname: Yun
authors.affiliation: 1 Division of Humanities and Social Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.
authors.forename: Yoo Kyoung
authors.initials: YK
authors.lastname: Han
authors.affiliation: 2 Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.
authors.forename: Byung Tae
authors.initials: BT
authors.lastname: Choi
authors.affiliation: 2 Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.
authors.forename: Hwa Kyoung
authors.initials: HK
authors.lastname: Shin
authors.affiliation: 1 Division of Humanities and Social Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.
authors.forename: Jin Ung
authors.initials: JU
authors.lastname: Baek
mesh_terms: D057225:Data Mining; D006801:Humans; D055670:Medicine, Korean Traditional; D018697:Nootropic Agents; D028321:Plant Preparations
chemical_list: D018697:Nootropic Agents; D028321:Plant Preparations