title: A New Graphene Derivative: Hydroxylated Graphene with Excellent Biocompatibility.
abstract: Graphene derivatives (such as graphene oxide and hydrogenated graphene) have been widely investigated because of their excellent properties. Here, we report large-scale (kilogram scale) synthesis of a new unique graphene derivative: hydroxylated graphene (G-OH). The exclusive existence form of oxygen-containing groups in G-OH is hydroxyl, which was verified by spectral characterization and quantitative halogenating reaction. It is very interesting that both the wettability and electrical conductivity show reversible change in halogenating and hydrolysis reaction cycles, which demonstrates the versatility of G-OH. Most importantly, the hydrophilicity and weak inductive nature of G-OH provides a well microenvironment for the cells adhesion and proliferation. On G-OH paper, rat adipose tissue-derived stromal cells exhibited a typical fibroblast-like shape with high rate of increase and survival after 3 day of incubation. This G-OH paper with good mechanical property is expected to be a new biomaterial for bone, vessel and skin regeneration.
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine , Shanghai 20011, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Deng
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.|Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine , Shanghai 20011, China.
authors.forename: Jipeng
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.
authors.forename: Peng
authors.initials: P
authors.lastname: He
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.|School of Physical Science and Technology, ShanghaiTech University , Shanghai 200031, China.
authors.forename: Suyun
authors.initials: S
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.
authors.forename: Xiuming
authors.initials: X
authors.lastname: Bu
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.
authors.forename: Zengfeng
authors.initials: Z
authors.lastname: Di
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.
authors.forename: Siwei
authors.initials: S
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.|Shanghai SIMBATT Energy Co. , Shanghai 201821, China.
authors.forename: Guqiao
authors.initials: G
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science , Shanghai 20050, China.|School of Physical Science and Technology, ShanghaiTech University , Shanghai 200031, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xie
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D004553:Electric Conductivity; D006108:Graphite; D010087:Oxides; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D010087:Oxides; D006108:Graphite
keywords: biomaterial; graphene derivative; hydroxylated graphene; regeneration; reversible