title: Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia.
abstract: OBJECTIVE
  To investigate whether serum levels of 19 eicosanoids are associated with pre-eclampsia.
  
  
  METHODS
  A case-control study was performed using data for pregnant women with pre-eclampsia, normotensive pregnant women, and nonpregnant women, for all of whom serum samples had been collected at a hospital in Shanghai, China, between December 2012 and December 2013. Ultra-performance liquid chromatography-tandem mass spectrometry was used to measure the serum levels of 19 eicosanoids.
  
  
  RESULTS
  Overall, 49 pregnant women with pre-eclampsia, 26 normotensive pregnant women, and 14 nonpregnant women were included. Women with pre-eclampsia had significantly higher serum levels of 11,12-epoxyeicosatrienoic acid (11,12-EET), the hydroxyeicosatetraenoic acids 5-HETE, 8-HETE, 12-HETE, and 15-HETE, and leukotriene B4 than did women with a normal pregnancy and nonpregnant women, both before and after the onset of pre-eclampsia (P<0.01 for all comparisons). Women with severe pre-eclampsia had significantly higher serum levels of 5-HETE, 15-HETE, and leukotriene B4 than did women with mild pre-eclampsia, women with a normal pregnancy, and nonpregnant women (P<0.01 for all comparisons).
  
  
  CONCLUSIONS
  The eicosanoids 11,12-EET, 5-HETE, 8-HETE, 12-HETE, 15-HETE, and leukotriene B4 might play important parts in the occurrence and development of pre-eclampsia.
authors.affiliation: Clinical Laboratory Department, Baoshan Branch of Shanghai First People's Hospital, Shanghai, China; Clinical Laboratory Department, People's Hospital of Dali Bai Autonomous Prefecture, Dali, China.
authors.forename: Anxiong
authors.initials: A
authors.lastname: Long
authors.affiliation: Clinical Laboratory Department, People's Hospital of Dali Bai Autonomous Prefecture, Dali, China.
authors.forename: Shungao
authors.initials: S
authors.lastname: Ma
authors.affiliation: Clinical Laboratory Department, Baoshan Branch of Shanghai First People's Hospital, Shanghai, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute of Pediatrics, Xinhua Hospital, Shanghai, China.
authors.forename: Na
authors.initials: N
authors.lastname: Lin
authors.affiliation: Institute of Pediatrics, Xinhua Hospital, Shanghai, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhan
authors.affiliation: Clinical Laboratory Department, Affiliated Hospital of Ningbo University, Ningbo, China.
authors.forename: Shuaijun
authors.initials: S
authors.lastname: Lu
authors.affiliation: Clinical Laboratory Department, Jiujiang First People's Hospital, Jiujiang, China.
authors.forename: Yuli
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Clinical Laboratory Department, Baoshan Branch of Shanghai First People's Hospital, Shanghai, China.
authors.forename: Liansheng
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Clinical Laboratory Department, Baoshan Branch of Shanghai First People's Hospital, Shanghai, China. Electronic address: longyitandoc@163.com.
authors.forename: Longyi
authors.initials: L
authors.lastname: Tan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D015777:Eicosanoids / Q000097:blood*; D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000097:blood*; D007975:Leukotriene B4 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015777:Eicosanoids; D006893:Hydroxyeicosatetraenoic Acids; D007975:Leukotriene B4
keywords: Eicosanoids; Epoxyeicosatrienoic acid; Hydroxyeicosatetraenoic acid; Leukotriene B4; Pre-eclampsia