title: Modeling Human Graft-Versus-Host Disease in Immunocompromised Mice.
abstract: Hematopoietic stem cell transplantation (HSCT) from an allogeneic donor is an effective form of cancer immunotherapy, especially for acute leukemias. HSCT is however frequently complicated by the occurrence of graft-versus-host disease (GVHD). Immunocompromised mice infused with human T cells often develop a clinical syndrome resembling human GVHD (xenogeneic or X-GVHD). Herein, we describe a method for inducing X-GVHD in a highly reproducible manner. Given the human nature of immune effectors, this xenogeneic model can be routinely adopted for screening the efficacy of new treatments for GVHD.
authors.affiliation: Innovative Immunotherapies Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milano, 21032, Italy.|Vita-Salute San Raffaele University, Milan, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Norelli
authors.affiliation: Innovative Immunotherapies Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milano, 21032, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Camisa
authors.affiliation: Vita-Salute San Raffaele University, Milano, Italy. bondanza.attilio@hsr.it.|Innovative Immunotherapies Unit, IRCCS San Raffaele Hospital Scientific Institute, Via Olgettina 60, Milano, 21032, Italy. bondanza.attilio@hsr.it.
authors.forename: Attilio
authors.initials: A
authors.lastname: Bondanza
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000637:transplantation; D016688:Mice, Inbred NOD; D016513:Mice, SCID
keywords: Hematopoietic stem cell transplantation (HSCT); Immunocompromised mice; Xenogeneic graft-versus-host disease (X-GVHD)