title: Fatigue: Where Did We Come from and How Did We Get Here?
abstract: : This paper highlights some key concepts related to fatigue and the seminal role of the 1981 Ciba Foundation Symposia "Human Muscle Fatigue: Physiological Mechanisms" chaired by R.H.T. Edwards in consolidating key ideas that have moved the study of fatigue forward since that time. I also consider these concepts in their historical context via the pioneering work of the Italian physiologist and social activist Angelo Mosso in the late 1800s. Finally, fatigue as a multidimensional concept with implications beyond muscle physiology is considered.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyner
mesh_terms: D005221:Fatigue / Q000191:economics / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D018763:Muscle Fatigue / Q000502:physiology*; D013177:Sports / Q000502:physiology