title: High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells.
abstract: Fatty acid-binding proteins (FABPs) are responsible for binding and storing hydrophobic ligands such as long-chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP5 gene is upregulated in colorectal cancer cells compared to normal colon cells in a manner that correlates with disease stage and that FABP5 significantly promotes colorectal cancer cell growth and metastatic potential. Thus, FABP5 might be a promising prognostic or therapeutic biomarker candidate in human colorectal cancer.
authors.affiliation: Interdisciplinary Graduate School of Science and Technology Shinshu University Minami-minowa Kami-ina Nagano Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kawaguchi
authors.affiliation: Department of Bioscience and Biotechnology Faculty of Agriculture Shinshu University Minami-minowa Kami-ina Nagano Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Senga
authors.affiliation: Department of Bioscience and Biotechnology Faculty of Agriculture Shinshu University Minami-minowa Kami-ina Nagano Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kubota
authors.affiliation: Department of Bioscience and Biotechnology Faculty of Agriculture Shinshu University Minami-minowa Kami-ina Nagano Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Molecular Pathology Laboratory Department of Molecular and Clinical Cancer Medicine The University of Liverpool UK.
authors.forename: Youqiang
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Interdisciplinary Graduate School of Science and Technology Shinshu University Minami-minowa Kami-ina Nagano Japan; Department of Bioscience and Biotechnology Faculty of Agriculture Shinshu University Minami-minowa Kami-ina Nagano Japan; Department of Interdisciplinary Genome Sciences and Cell Metabolism Institute for Biomedical Sciences Interdisciplinary Cluster for Cutting-Edge Research Shinshu University Minami-minowa Kami-ina Nagano Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
keywords: FABP5; colorectal cancer; fatty acid; fatty acid‐binding proteins; lipid metabolism; metastasis