title: Histopathology of ipsilateral and contralateral ovaries and plasma interleukin 6 levels after unilateral ovarian torsion.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the time-dependent histopathologic changes in both ovaries and to determine the time-dependent levels of plasma interleukin 6 (IL-6) after unilateral ovarian torsion.
  
  
  METHODS
  An experimental animal study included 48 female Sprague-Dawley rats which were distributed to six groups: control group (Group 1), sham-operated control group (Group 2), and four unilateral ovarian torsion groups with torsion duration of three, six, 12, and 24 hours (Group 3, 4, 5, and 6, respectively). Histopathologic criteria (follicular degeneration, vascular congestion, hemorrhage, inflammatory cell infiltration, and total tissue damage score) were evaluated in both ovaries, and plasma IL-6 levels were measured.
  
  
  RESULTS
  At 24 hours after torsion began, mean total tissue damage score was similar between ovaries that had torsion and contralateral ovaries. Mean plasma IL-6 level did not change during the 24 hours after torsion began (p = 0.584).
  
  
  CONCLUSIONS
  In addition to ovaries that had torsion, histopathologic abnormalities also occurred in contralateral ovaries. These results suggest that contralateral ovaries are not quiescent after unilateral ovarian torsion. Plasma IL-6 levels did not change significantly during the 24 hours after ovarian torsion began, resulting in a limitation of its diagnostic use in the early course of the disease.
authors.forename: L
authors.initials: L
authors.lastname: Karakoc-Sokmensuer
authors.forename: S
authors.initials: S
authors.lastname: Hacivelioglu
authors.forename: A
authors.initials: A
authors.lastname: Demir
authors.forename: M
authors.initials: M
authors.lastname: Köse
authors.forename: F F
authors.initials: FF
authors.lastname: Kaymaz
authors.forename: D U
authors.initials: DU
authors.lastname: Cakir
authors.forename: G
authors.initials: G
authors.lastname: Bozdag
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015850:Interleukin-6 / Q000097:blood*; D010049:Ovarian Diseases / Q000097:blood / Q000473:pathology*; D010053:Ovary / Q000002:abnormalities / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014102:Torsion Abnormality / Q000097:blood / Q000473:pathology*
chemical_list: D015850:Interleukin-6