title: Zinc supplementation prolongs the latency of hyperthermia-induced febrile seizures in rats.
abstract: Some studies have shown a relationship between febrile seizures and zinc levels. The lowest dose zinc supplementation in pentylenetetrazole seizure model has a protective effect. But, zinc pretreatment has no effect in maximal electroshock model. However, it is unclear how zinc supplementation affects hyperthermia-induced febrile seizures. The aim of the present study was to investigate the effects of zinc supplementation on febrile seizures in male Sprague-Dawley rats. The rats were randomly assigned to four groups. Zinc supplementation was commenced 5 days prior to febrile seizure induction by placing the animals in a water bath at 45°C. We measured the rectal temperature and determined the febrile seizure latency, duration, and stage. In the zinc-supplemented group, both the seizure latency and the rectal temperature triggering seizure initiation were significantly higher than in the other groups. We suggest that zinc supplementation can positively modulate febrile seizure pathogenesis in rats.
authors.affiliation: Department of Physiology, Faculty of Medicine, Baskent University , Ankara , Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Aydın
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Baskent University , Ankara , Turkey.
authors.forename: S R
authors.initials: SR
authors.lastname: Erdem
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Baskent University , Ankara , Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Yazıcı
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005334:Fever / Q000150:complications / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects*; D003294:Seizures, Febrile / Q000473:pathology*; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D015032:Zinc
keywords: body temperature; febrile seizure; latency; seizure threshold; zinc supplement