title: Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk.
abstract: BACKGROUND
  The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis.
  
  
  METHODS
  One hundred patients were included in the study and divided into two groups as follows; Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations.
  
  
  RESULTS
  There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant (p < 0.005).
  
  
  CONCLUSIONS
  According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.
authors.affiliation: Abant Izzet Baysal University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bolu, TURKEY, toptasorcun@yahoo.com.
authors.forename: Ü
authors.initials: Ü
authors.lastname: Özan
authors.forename: Z
authors.initials: Z
authors.lastname: Ocak
authors.forename: F
authors.initials: F
authors.lastname: Özan
authors.forename: E-A
authors.initials: EA
authors.lastname: Oktay
authors.forename: O
authors.initials: O
authors.lastname: Toptaş
authors.forename: H
authors.initials: H
authors.lastname: Şahman
authors.forename: I
authors.initials: I
authors.lastname: Yikilgan
authors.forename: H
authors.initials: H
authors.lastname: Oruçoğlu
authors.forename: K
authors.initials: K
authors.lastname: Er
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D010483:Periapical Diseases / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051196:Toll-Like Receptor 3 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D051193:Toll-Like Receptors
chemical_list: C495342:TLR2 protein, human; C495344:TLR3 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051196:Toll-Like Receptor 3; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors