title: Soluble tumour necrosis factor receptor type II and survival in colorectal cancer.
abstract: Chronic inflammation may play a role in colorectal cancer (CRC) pathogenesis. The relationship between soluble tumour necrosis factor receptor type II (sTNF-RII) and survival among CRC patients is not well defined.
  
  
  
  We prospectively evaluated the association between pre-diagnosis plasma levels of sTNF-RII and mortality in 544 CRC patients from the Nurses' Health Study and Health Professionals Follow-Up Study diagnosed from 1990 to 2010. Primary and secondary end points were overall and CRC-specific mortality, respectively. Cox proportional hazards models were used to calculate multivariate hazard ratios for mortality.
  
  
  
  Higher sTNF-RII levels were significantly associated with increased overall mortality (multivariate HR=1.48, 95% CI 1.02-2.16, P-trend=0.006), but not with CRC-specific mortality (HR=1.23, 95% CI 0.72-2.08, P-trend=0.34). In subgroup analyses, among regular aspirin users, those with higher sTNF-RII levels had an adjusted HR of 0.52 (95% CI 0.20-1.33) for overall mortality compared with those with lower sTNF-RII levels, whereas among nonregular aspirin users the adjusted HR was 2.26 (95% CI 1.23-4.01, P for interaction=0.53).
  
  
  
  Among CRC patients, higher sTNF-RII levels are associated with a significant increase in overall mortality, but not CRC-specific mortality. The role of inflammation and anti-inflammatory medications in survival of CRC patients warrants further exploration.
authors.affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Babic
authors.affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.|Division of Hematology and Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Sonali M
authors.initials: SM
authors.lastname: Shah
authors.affiliation: Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Department of Epidemiology, Harvard T. H. School of Public Health, Boston, MA 02215, USA.
authors.forename: Mingyang
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
authors.forename: Kana
authors.initials: K
authors.lastname: Wu
authors.affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Meyerhardt
authors.affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.|Department of Epidemiology, Harvard T. H. School of Public Health, Boston, MA 02215, USA.|Division of MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Shuji
authors.initials: S
authors.lastname: Ogino
authors.affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Department of Epidemiology, Harvard T. H. School of Public Health, Boston, MA 02215, USA.|Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Edward L
authors.initials: EL
authors.lastname: Giovannucci
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.|Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Chan
authors.affiliation: Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Department of Epidemiology, Harvard T. H. School of Public Health, Boston, MA 02215, USA.|Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Meir J
authors.initials: MJ
authors.lastname: Stampfer
authors.affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Fuchs
authors.affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Kimmie
authors.initials: K
authors.lastname: Ng
mesh_terms: D000328:Adult; D002908:Chronic Disease; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood* / Q000378:metabolism
chemical_list: D047889:Receptors, Tumor Necrosis Factor, Type II