title: [Phospholipids metabolism disorders in acute stroke].
abstract: The disturbances of cerebral circulation results in the violation of phospholipid metabolism. Activation of lipid peroxidation and protein kinase C and release of intracellular calcium leads to disruption of the homeostasis of phosphatidylcholine. The use of cytidine-5-diphosphocholine, which is used as an intermediate compound in the biosynthesis of phospholipids of the cell membrane, helps to stabilize cell membranes, and reduce the formation of free radicals.
authors.affiliation: GBOU VPO.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Solovieva
authors.affiliation: Rossijskij natsional'nyj issledovatel'skij meditsinskij universitet im. N.I. Pirogova', Moskva.
authors.forename: K I
authors.initials: KI
authors.lastname: Farrahova
authors.affiliation: GBOU VPO.
authors.forename: A N
authors.initials: AN
authors.lastname: Karneev
authors.affiliation: Rossijskij natsional'nyj issledovatel'skij meditsinskij universitet im. N.I. Pirogova', Moskva.
authors.forename: D T
authors.initials: DT
authors.lastname: Chipova
mesh_terms: D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation; D003566:Cytidine Diphosphate Choline / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D005609:Free Radicals / Q000037:antagonists & inhibitors; D006801:Humans; D015227:Lipid Peroxidation; D008066:Lipolysis; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010743:Phospholipids / Q000378:metabolism*; D020521:Stroke / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D018696:Neuroprotective Agents; D010713:Phosphatidylcholines; D010743:Phospholipids; D003566:Cytidine Diphosphate Choline