title: The Role of Statins in the Activation of Heme Oxygenase-1 in Cardiovascular Diseases.
abstract: Cardiovascular diseases (CVD) are associated with the dysfunction of endothelium that regulates the contractile state of vascular walls and cellular composition. Recent large clinical trials indicated that lipid-modifying interventions decrease the risk of CVD in patients with hypercholesterolemia and in those with relatively normal levels of LDL cholesterol. They also highlighted lipid-independent role of well-established lipid-lowering drugs- statins- which inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and are used in the treatment of hypercholesterolemia and reduction of atherosclerosis. Novel therapeutic approaches of statins include their influence on heme oxygenase 1 (HO-1) and HO-1 related signaling pathways such as activator protein (AP)-1, protein kinase G (PKG), extracellular matrix-regulated kinase (ERK), p38 MAPK or NFκB in vascular wall cells. This review aimed to describe the molecular mechanisms involved in the induction of HO-1 under different statins in the most common CVD.
authors.affiliation: Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow. Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piechota-Polanczyk
authors.forename: Alicja
authors.initials: A
authors.lastname: Jozkowicz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D002986:Clinical Trials as Topic; D004789:Enzyme Activation / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1
keywords: Abdominal aortic aneurysm; antioxidants; atherosclerosis; cardiac diseases; cardiovascular diseases; heme oxygenase-
  1; oxidative stress; statins