title: Evolution and functions of Oct4 homologs in non-mammalian vertebrates.
abstract: PouV class transcription factor Oct4/Pou5f1 is a central regulator of indefinite pluripotency in mammalian embryonic stem cells (ESCs) but also participates in cell lineage specification in mouse embryos and in differentiating cell cultures. The molecular basis for this versatility, which is shared between Oct4 and its non-mammalian homologs Pou5f1 and Pou5f3, is not yet completely understood. Here, I review the current understanding of the evolution of PouV class transcription factors and discuss equivalent and diverse roles of Oct4 homologs in pluripotency, differentiation, and cell behavior in different vertebrate embryos. This article is part of a Special Issue entitled: The Oct Transcription Factor Family, edited by Dr. Dean Tantin.
authors.affiliation: Developmental Biology Unit, Institute of Biology I, Faculty of Biology, and Center for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University, Freiburg, Germany. Electronic address: daria.onichtchouk@biologie.uni-freiburg.de.
authors.forename: Daria
authors.initials: D
authors.lastname: Onichtchouk
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation; D019070:Cell Lineage / Q000235:genetics; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D050814:Octamer Transcription Factor-3 / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D014982:Xenopus laevis / Q000145:classification / Q000235:genetics / Q000254:growth & development; D015027:Zebrafish / Q000145:classification / Q000235:genetics / Q000254:growth & development; D029961:Zebrafish Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; C085437:Pou5f3 protein, zebrafish; D029961:Zebrafish Proteins
keywords: Pct4; Pluripotency; Pou5f1; Pou5f3; Xenopus; Zebrafish