title: Inflammatory pseudotumour of the maxilla.
abstract: Inflammatory pseudotumour (IP), also known as inflammatory myofibroblastic tumour (IMT), is a rare lesion of the maxillofacial skeleton and a diagnosis by exclusion. We describe three cases which affected the maxilla, two women and one man of ages 67, 56 and 70 years at presentation. All showed the typical, rather non-specific histopathological features. IgG4-positive plasma cells varied greatly in prominence, and none of the three lesions expressed ALK-1. Both women responded to steroids and radiotherapy, though one also required azathioprine. Despite maxillectomy, radiotherapy, steroids and cyclophosphamide, the man suffered intracranial spread and succumbed to persistent disease. The cases described here demonstrate the clinicopathological difficulties presented by this entity and its aggressive, unpredictable behaviour.
authors.affiliation: Department of Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, RH19 3DZ, UK. akichen@doctors.net.uk.|, 6 Smeeds Close, East Grinstead, West Sussex, RH19 3AL, UK. akichen@doctors.net.uk.
authors.forename: A
authors.initials: A
authors.lastname: Kichenaradjou
authors.affiliation: Department of Histopathology, Queen Victoria Hospital, East Grinstead, West Sussex, RH19 3DZ, UK.
authors.forename: A W
authors.initials: AW
authors.lastname: Barrett
authors.affiliation: Department of Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, RH19 3DZ, UK.
authors.forename: P
authors.initials: P
authors.lastname: Norris
authors.affiliation: Kent Oncology Centre, Maidstone Hospital, Maidstone, ME16 9QQ, UK.
authors.forename: N
authors.initials: N
authors.lastname: Rowell
authors.affiliation: Department of Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, RH19 3DZ, UK.
authors.forename: L
authors.initials: L
authors.lastname: Newman
mesh_terms: D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003131:Combined Modality Therapy; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008439:Maxillary Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D011239:Prednisolone; D001379:Azathioprine
keywords: Inflammatory myofibroblastic tumour; Pseudotumour