title: Effect of Blueberry Anthocyanins Malvidin and Glycosides on the Antioxidant Properties in Endothelial Cells.
abstract: The objective of this research was to survey the antioxidant functional role of the main anthocyanins of blueberries in endothelial cells. Changes on the reactive oxygen species (ROS), xanthine oxidase-1 (XO-1), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) in cells of malvidin and the two glycosides were investigated. The results showed that these anthocyanins decreased the levels of ROS and XO-1 but increased the levels of SOD and HO-1. Glycosides improved the antioxidant capacity of malvidin to a great extent. The changes in the antioxidant properties of malvidin-3-glucoside were more pronounced than malvidin-3-galactoside. Variation in levels of malvidin-3-glucoside and malvidin-3-galactoside had a significant impact on antioxidant properties to different extents. It indicates that blueberries are a good resource of anthocyanins, which can protect cells from oxidative deterioration and use blueberry as a potential functional food to prevent diseases related to oxidative stress.
authors.affiliation: Institute of Farm Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
authors.forename: Wuyang
authors.initials: W
authors.lastname: Huang
authors.affiliation: Institute of Farm Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
authors.forename: Yunming
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Institute of Farm Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Zhongquan
authors.identifier: 0000-0002-5316-117X
authors.initials: Z
authors.lastname: Sui
authors.affiliation: College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
authors.forename: Weihong
authors.identifier: 0000-0002-6093-2104
authors.initials: W
authors.lastname: Min
mesh_terms: D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D029798:Blueberry Plants; D002478:Cells, Cultured; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology; D051547:Heme Oxygenase-1 / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D000072105:Superoxide Dismutase-1 / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D005960:Glucosides; D006027:Glycosides; D017382:Reactive Oxygen Species; C065861:malvidin; C458419:malvidin-3-glucoside; D051547:Heme Oxygenase-1; D000072105:Superoxide Dismutase-1; C458399:malvidin 3-galactoside