title: Correlations of serum visfatin and metabolisms of glucose and lipid in women with gestational diabetes mellitus.
abstract: OBJECTIVE
  Visfatin is a newly discovered adipocytokine hormone, which exerts an insulin-like effect by binding to the insulin receptor-1. However, the role of visfatin in human gestational diabetes mellitus (GDM) remains controversial. The purpose of the present study was to investigate the correlation between serum visfatin and metabolism of glucose and lipid in GDM.
  
  
  METHODS
  This was a prospective study. A total of 38 GDM patients and 35 age- and body mass index-matched controls were studied between January 2012 and October 2013. Fasting serum levels of visfatin, fasting plasma glucose, hemoglobin A1c and lipid profile were measured. Two-tailed t-tests and Pearson's correlation coefficient were used to analyze the data.
  
  
  RESULTS
  Perinatal visfatin levels were negatively correlated with fasting plasma glucose, insulin resistance index and triglycerides in controls (r = -0.47, -0.51, -0.57, respectively; P < 0.05), and positively correlated with high-density lipoprotein cholesterol (r = 0.32, P < 0.05). A positive correlation with visfatin level only appeared in weight gain and body mass index in women with GDM (r = 0.36, 0.45, respectively; P < 0.05).
  
  
  CONCLUSIONS
  Visfatin appears to be involved in glucose and lipid metabolism regulation and insulin resistance, suggesting a role in GDM pathogenesis.
authors.affiliation: Obstetrical Department Women's Hospital School of Medicine Zhejiang University Hangzhou Zhejiang Province China.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Obstetrical Department Women's Hospital School of Medicine Zhejiang University Hangzhou Zhejiang Province China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Obstetrical Department Women's Hospital School of Medicine Zhejiang University Hangzhou Zhejiang Province China.
authors.forename: Jianyun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Obstetrical Department Women's Hospital School of Medicine Zhejiang University Hangzhou Zhejiang Province China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Fang
authors.affiliation: Obstetrical Department Women's Hospital School of Medicine Zhejiang University Hangzhou Zhejiang Province China.
authors.forename: Danqing
authors.initials: D
authors.lastname: Chen
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D054409:Nicotinamide Phosphoribosyltransferase; D005947:Glucose
keywords: Gestational diabetes mellitus; Glucose and lipid metabolism; Visfatin