title: Prognostic value of angiopoietin-2 in patients with chronic heart failure.
abstract: OBJECTIVE
  The analysis of biomarkers with a prognostic value in chronic heart failure (CHF) is in constant progress. This study aimed to evaluate the short-term prognostic value of angiopoietin-2 (Ang2), galectin-3 (Gal-3), myeloperoxidase (MPO), endostatin (End), and pro-brain natriuretic peptide (pro-BNP) as a conventionally accepted prognosis biomarker in CHF patients.
  
  
  RESULTS
  146 consecutive patients with CHF due to left ventricular systolic dysfunction (LVEF<40% at echocardiography) were enrolled, and underwent serum/blood sample analysis after 12-h fasting. Within 1year, 25 (17%) patients died (D) or underwent heart transplantation (HT). D+HT patients showed higher values of Ang2 (Log Ang2: 8.97±0.52 vs. 8.45±0.69, p=0.0004), myeloperoxidase (MPO) (Log MPO: 5±1.1 vs. 4.2±1.3, p=0.005) and pro-BNP (Log pro-BNP: 8.70±0.9 vs. 7.45±1.3, p<0.00001). At univariate Cox regression, pro-BNP and Ang2 were the best predictors of 1-year mortality, with area under the curve (AUC)=0.78 for pro-BNP (68% sensitivity and 82% specificity to predict outcome for a cut-off value of 5109pg/mL, 95% confidence interval [CI] 0.70-0.85, p<0.0001) and AUC=0.73 for Ang2 (84% sensitivity and 61% specificity to predict outcome for a cut-off value of 5175pg/mL, 95% CI 0.65-0.80, p<0.0001). At multivariate analysis, pro-BNP was the only predictor of one-year D/HT.
  
  
  CONCLUSIONS
  In our series of CHF patients, Ang2 and pro-BNP showed the best predictive value for 1-year outcome, while only pro-BNP could independently predict D/HT.
authors.affiliation: Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Via per Revislate 13, 28010 Veruno (No), Italy. Electronic address: ermanno.eleuteri@fsm.it.
authors.forename: Ermanno
authors.initials: E
authors.lastname: Eleuteri
authors.affiliation: Laboratory of Cytoimmunopathology of Heart and Lung, Salvatore Maugeri Foundation, IRCCS, Via per Revislate 13, 28010 Veruno (No), Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Di Stefano
authors.affiliation: Bioengineering Department, Salvatore Maugeri Foundation, IRCCS, Via per Revislate 13, 28010 Veruno (No), Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Giordano
authors.affiliation: Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Via per Revislate 13, 28010 Veruno (No), Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Corrà
authors.affiliation: Division of Cardiology, Presidio Major, Salvatore Maugeri Foundation, IRCCS, Torino, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Tarro Genta
authors.affiliation: Laboratory of Cytoimmunopathology of Heart and Lung, Salvatore Maugeri Foundation, IRCCS, Via per Revislate 13, 28010 Veruno (No), Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Gnemmi
authors.affiliation: Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Via per Revislate 13, 28010 Veruno (No), Italy.
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Giannuzzi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000378:metabolism / Q000401:mortality* / Q000628:therapy*; D016027:Heart Transplantation / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D033921:Vesicular Transport Proteins / Q000097:blood*
chemical_list: D015415:Biomarkers; C555023:VPS51 protein, human; D033921:Vesicular Transport Proteins; D020097:Natriuretic Peptide, Brain
keywords: Angiopoietin-2; Biomarkers; Galectin-3; Heart failure; Myeloperoxidase; Pro-BNP