title: The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease.
abstract: Autophagy plays an important role in the removal of membrane bound organelles during the last stage of erythropoiesis as the enucleate reticulocyte matures into the erythrocyte. Autophagic vesicles are expelled from the reticulocyte as intact, inside-out, phosphatidylserine (PS) decorated vesicles and are subsequently removed during splenic passage. Failure to remove these vesicles causes the elevation in PS exposed red cells in Sickle Cell Disease.
authors.affiliation: a Bristol Institute for Transfusion Sciences, NHS Blood and Transplant , Filton , Bristol , UK.
authors.forename: Tosti J
authors.initials: TJ
authors.lastname: Mankelow
authors.affiliation: a Bristol Institute for Transfusion Sciences, NHS Blood and Transplant , Filton , Bristol , UK.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Griffiths
authors.affiliation: b Joint Red Cell Unit, University College London NHS Foundation Trust, Haematology Department , London , UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Trompeter
authors.affiliation: a Bristol Institute for Transfusion Sciences, NHS Blood and Transplant , Filton , Bristol , UK.
authors.forename: Joanna F
authors.initials: JF
authors.lastname: Flatt
authors.affiliation: a Bristol Institute for Transfusion Sciences, NHS Blood and Transplant , Filton , Bristol , UK.
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Cogan
authors.affiliation: a Bristol Institute for Transfusion Sciences, NHS Blood and Transplant , Filton , Bristol , UK.
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Massey
authors.affiliation: a Bristol Institute for Transfusion Sciences, NHS Blood and Transplant , Filton , Bristol , UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Anstee
mesh_terms: D000755:Anemia, Sickle Cell / Q000473:pathology*; D001343:Autophagy; D002454:Cell Differentiation; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D012156:Reticulocytes / Q000166:cytology*