title: Physical activity levels and quality of life relate to collagen turnover and inflammation changes after running.
abstract: The purpose of this study was to determine whether an association existed between self-reported symptom and function scores and tissue turnover or inflammatory biomarker changes after a running bout among individuals with and without an acute knee-injury history. A pre-test/post-test prospective cohort study design (Level II) of 22 participants was conducted. Eleven physically active individuals with a history of anterior cruciate ligament surgery and/or meniscus surgery within 4 years of study participation were matched to 11 healthy control participants. All participants completed self-reported outcome measures (Knee Osteoarthritis Outcomes Score and Tegner activity level) assessing knee symptoms and functional levels prior to the run. Blood samples were taken both pre- and post-30-minute run at a prescribed pace on a treadmill to determine serum biomarker concentration changes. Tegner activity levels were inversely related to type II collagen/type II collagen synthesis marker ratio biomarker changes after the run (r = -0.45, p = 0.01). Quality-of-life scores pre-exercise were inversely related to interleukin-1β changes after the run (r = -0.50, p = 0.02). No other correlation coefficients were statistically significant (r = -0.39 to 0.36). Ultimately, individuals with lower activity and quality-of-life scores experienced greater increases in collagen turnover and inflammation after a running bout, respectively. A gradual increase in activity (e.g., frequency, duration, intensity) may be warranted in this group prior to returning to activities that involve running. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:612-617, 2017.
authors.affiliation: Department of Sports Medicine, West Chester University of Pennsylvania, 855 S. New Street, 222L Sturzebecker HSC, West Chester, PA, 19383.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Cattano
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA, 02111.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Driban
authors.affiliation: Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, PA, 19140.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Barbe
authors.affiliation: Department of Kinesiology, Temple University, 259 Pearson Hall, Philadelphia, PA, 19122.
authors.forename: Ryan
authors.initials: R
authors.lastname: Tierney
authors.affiliation: Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, PA, 19140.
authors.forename: Mamta
authors.initials: M
authors.lastname: Amin
authors.affiliation: College of Public Health, Temple University, Polett Walk, G20 Sullivan Hall, Philadelphia, PA, 19140.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sitler
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003094:Collagen / Q000378:metabolism*; D015444:Exercise; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D012420:Running / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003094:Collagen
keywords: articular cartilage; knee injuries; osteoarthritis; patient outcome assessment