title: Oral oxybutynin for the treatment of hyperhidrosis: outcomes after one-year follow-up.
abstract: OBJECTIVE
  Although many treatments are available to address hyperhidrosis, the results are not always satisfactory. The aim of the study was to assess the effectiveness, optimal dosage regimen and long-term safety of oral oxybutynin in the treatment of hyperhidrosis.
  
  
  METHODS
  A retrospective review was performed on 110 patients who underwent treatment for hyperhidrosis between February 2007 and December 2013. Their response to treatment was evaluated using the hyperhidrosis disease severity scale at baseline, 3 and 12 months. Additionally, the safety and effectiveness of different up-dosing and fixed-dose regimens were compared.
  
  
  RESULTS
  After 3 months of treatment, 87 of the 110 patients (79%) had responded (63%), which was considered excellent. After 12 months, 63 patients (62%) continued to respond, and the response was considered excellent in 50%. Nine patients were lost to follow up between month 3 and 12. In total, 77 and 70% of the patients who responded at 3 and 12 months, respectively, reported mild adverse events. No serious adverse events were observed. Treatment adherence was significantly higher among patients following the individualised up-dosing regimen.
  
  
  CONCLUSIONS
  Oral oxybutynin may be an effective and safe option for the long-term treatment of hyperhidrosis. To improve treatment adherence, oxybutynin dosing regimens should be individualised on the basis of the patient's tolerance and response.
authors.affiliation: Department of Dermatology, Hospital Costa del Sol, Marbella, Spain.|University of Málaga, Málaga, Spain.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Millán-Cayetano
authors.affiliation: Department of Dermatology, Hospital Costa del Sol, Marbella, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Del Boz
authors.affiliation: Research Unit, Hospital Costa del Sol, Marbella, Spain.|Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Marbella, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Rivas-Ruiz
authors.affiliation: Department of Dermatology, Hospital Costa del Sol, Marbella, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Blázquez-Sánchez
authors.affiliation: Department of Dermatology, Hospital Costa del Sol, Marbella, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Hernández Ibáñez
authors.affiliation: Department of Dermatology, Hospital Costa del Sol, Marbella, Spain.|Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Marbella, Spain.
authors.forename: Magdalena
authors.initials: M
authors.lastname: de Troya-Martín
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D008333:Mandelic Acids / Q000627:therapeutic use*; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult
chemical_list: D008333:Mandelic Acids; D018727:Muscarinic Antagonists; C005419:oxybutynin
keywords: hyperhidrosis; oxybutynin