title: The resveratrol-enriched rice DJ526 boosts motor coordination and physical strength.
abstract: The main objective of current genetic modifications in crops is to boost agricultural production or to develop GM crops with an improved nutrient profile by introducing a new trait to the plants. A GM crop surpassing the ability of the introduced genetic characteristics has not been developed yet. Here, we show that the resveratrol-enriched rice DJ526, a GM crop, has unexpectedly high beneficial health effects surpassing the introduced genetic characteristic of resveratrol synthetic ability. The synergistic effect of its innate and transgenic properties not only ameliorates age-related deterioration but also boosts motor coordination and physical strength during the aging process. The gene expression profiling analyses by DNA chip showed that the gene expression pattern of mice fed resveratrol-enriched rice DJ526 was very different from mice fed either resveratrol or Dongjin rice alone, respectively, modifying expression of genes related to aging regulation, cell differentiation, extracellular matrix, neurogenesis, or secretion.
authors.affiliation: Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54896, South Korea.
authors.forename: Hea-Jong
authors.initials: HJ
authors.lastname: Chung
authors.affiliation: Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54896, South Korea.
authors.forename: Satya Priya
authors.initials: SP
authors.lastname: Sharma
authors.affiliation: JINIS BDRD institute, JINIS Biopharmaceuticals Co., 948-9 Dunsan, Bongdong, Wanju, Chonbuk 55321, South Korea.
authors.forename: Hyeon-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Well-being Resources, Sunchon National University, Suncheon, Jeonnam 57922, South Korea.
authors.forename: So-Hyeon
authors.initials: SH
authors.lastname: Baek
authors.affiliation: Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54896, South Korea.
authors.forename: Seong-Tshool
authors.initials: ST
authors.lastname: Hong
mesh_terms: D000273:Adipose Tissue; D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D003094:Collagen / Q000737:chemistry; D018556:Crops, Agricultural / Q000737:chemistry / Q000235:genetics; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D005527:Food, Fortified; D020869:Gene Expression Profiling; D051379:Mice; D008810:Mice, Inbred C57BL; D009048:Motor Skills; D053580:Muscle Strength; D009753:Nutritive Value; D020411:Oligonucleotide Array Sequence Analysis; D012275:Oryza / Q000737:chemistry* / Q000235:genetics; D030821:Plants, Genetically Modified / Q000737:chemistry / Q000235:genetics; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry*
chemical_list: D013267:Stilbenes; D003094:Collagen; D000077185:Resveratrol