title: Serelaxin for the treatment of heart failure.
abstract: Outcomes for patients with acute heart failure remain suboptimal and treatments principally target improvement of symptoms. To date there has been no therapy approved for acute heart failure shown to improve mortality or readmission risk post-discharge. Serelaxin, a recombinant form of the naturally occurring polypeptide hormone relaxin, has demonstrated promise in preclinical and early clinical trials as a potentially novel therapy for acute heart failure. It is postulated through its anti-fibrotic and vasodilatory effects that this agent can improve outcomes in both the short and long term in these patients. Randomized clinical data has suggested that the medication is safe and well tolerated. However, definitive outcomes data is currently being assessed in a large multi-center trial.
authors.affiliation: a Division of Cardiology , Stony Brook University School of Medicine , Stony Brook , NY , USA.
authors.forename: Danyaal S
authors.initials: DS
authors.lastname: Moin
authors.affiliation: a Division of Cardiology , Stony Brook University School of Medicine , Stony Brook , NY , USA.
authors.forename: Michelle W
authors.initials: MW
authors.lastname: Bloom
authors.affiliation: a Division of Cardiology , Stony Brook University School of Medicine , Stony Brook , NY , USA.
authors.forename: Lampros
authors.initials: L
authors.lastname: Papadimitriou
authors.affiliation: a Division of Cardiology , Stony Brook University School of Medicine , Stony Brook , NY , USA.
authors.forename: Javed
authors.initials: J
authors.lastname: Butler
mesh_terms: D000208:Acute Disease; D002317:Cardiovascular Agents / Q000494:pharmacology; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D011994:Recombinant Proteins / Q000494:pharmacology; D012065:Relaxin / Q000494:pharmacology / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D011994:Recombinant Proteins; C577649:serelaxin protein, human; D012065:Relaxin
keywords: RELAX-AHF; Relaxin; heart failure; review; serelaxin