title: Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin.
abstract: Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys that are needed for proper clinical diagnosis and biomedical research conduct. The body weight information and blood type are also key success factors in allogeneic or xenogeneic models. Moreover, the biological parameters could be different according to the origin of the Cynomolgus monkey. However, there are limited references provided, especially of Cambodia origin. In this study, we measured average body weight of 2,518 Cynomolgus monkeys and analyzed hematology and serum biochemistry using 119 males, and determined blood types in 642 monkeys with Cambodia origin. The average body weight of male Cynomolgus monkeys were 2.56±0.345 kg and female group was 2.43±0.330 kg at the age from 2 to 3 years. The male group showed relatively sharp increased average body weight from the 3 to 4 age period compared to the female group. In hematology and biochemistry, it was found that most of the data was similar when compared to other references even though some results showed differences. The ABO blood type result showed that type A, B, AB, and O was approximately 15.6, 33.3, 44.2, and 6.9%, respectively. The main blood type in this facility was B and AB. These biological background references of Cambodia origin could be used to provide important information to researchers who are using them in their biomedical research.
authors.affiliation: Haeeun Life Science Research Institute, Orient Bio Inc., Sungnam, Korea.
authors.forename: Kangmoo
authors.initials: K
authors.lastname: Choi
authors.affiliation: Haeeun Life Science Research Institute, Orient Bio Inc., Sungnam, Korea.
authors.forename: Jaejin
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Veterinary Medicine, Kangwon National University, Chuncheon, Korea.
authors.forename: Min-Jae
authors.initials: MJ
authors.lastname: Lee
authors.affiliation: Production, Orient Cam Co., Ltd., Kampong Chhnang, Cambodia.
authors.forename: Seungsu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Production, Orient Cam Co., Ltd., Kampong Chhnang, Cambodia.
authors.forename: Kimhong
authors.initials: K
authors.lastname: In
authors.affiliation: Production, Orient Cam Co., Ltd., Kampong Chhnang, Cambodia.
authors.forename: Wilhelm C
authors.initials: WC
authors.lastname: Galano-Tan
authors.affiliation: Haeeun Biomedical Research Institute, Genia Inc., Sungnam, Korea.
authors.forename: Sanghun
authors.initials: S
authors.lastname: Jun
authors.affiliation: Haeeun Biomedical Research Institute, Genia Inc., Sungnam, Korea.
authors.forename: Kahee
authors.initials: K
authors.lastname: Cho
authors.affiliation: Haeeun Biomedical Research Institute, Genia Inc., Sungnam, Korea.
authors.forename: Yong-Hwa
authors.initials: YH
authors.lastname: Hwang
authors.affiliation: Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea.
authors.forename: Sung-Ju
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Haeeun Biomedical Research Institute, Genia Inc., Sungnam, Korea.
authors.forename: Wanje
authors.initials: W
authors.lastname: Park
keywords: Cynomolgus monkey; blood type; body weight; cambodia origin; hematology; serum biochemistry