title: The HLA-DRB1 allele polymorphisms and nasopharyngeal carcinoma.
abstract: Human leukocyte antigen (HLA)-DRB1 has been reported to influence individual's susceptibility to nasopharyngeal carcinoma (NPC) by many studies in recent years; however, these studies provided controversial results. The meta-analysis was thus conducted here to estimate the relationship between HLA-DRB1 polymorphisms and NPC. After an extensive review of journals from various databases (PubMed, the Web of Science, Embase, China National Knowledge Internet (CNKI), and Wanfang Database), 8 out of 69 case-control studies, including 778 cases and 1148 controls, were extracted. The results showed that 4 of 13 polymorphisms allele are statistically significantly associated with NPC, among them, HLA-DRB1*3, HLA-DRB1*9, and HLA-DRB1*10 may increase the risk of NPC while HLA-DRB1*01 has the opposite effect. The pooled odds ratio and 95 % confidence interval (CI) were 1.702 [95 % CI (1.047, 2.765)], 1.363 [95 % CI (1.029, 1.806)], 1.989 [95 % CI (1.042, 3.799)], and 0.461 [95 % CI (0.315, 0.676)], respectively. In a further ethnicity-based subgroup analysis, HLA-DRB1*08, HLA-DRB1*11, and HLA-DRB1*16 were found to be linked with NPC in Asian, Tunisian, and Caucasian, respectively. In Asian, HLA-DRB1*03, 08, and 10 may elevate the risk whereas HLA-DRB1*09 could lower it. In Tunisian, HLA-DRB1*01 and 11 are the protective factors while HLA-DRB1*03 is the only risk factor. In Caucasian, HLA-DRB1*01 and 03 increase the risk and HLA-DRB1*16 lowers it. The most frequent statistically associated gene is found to be HLA-DRB1*03 which has protective influence on Asian and Tunisian. In conclusion, HLA-DRB1*01, DRB1*03, DRB1*09, and DRB1*10 are related with NPC susceptibility, and the association of HLA-DRB1*08, DRB1*11, and DRB1*16 with NPC risk are significantly different in different ethnicities.
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China.|Shanghai Biomedical Laboratory, Shanghai, 200436, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Pathophysiology, School of Preclinical Sciences, Guangxi Medical University, Nanning, 530021, China.
authors.forename: Kaihui
authors.initials: K
authors.lastname: Yu
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors.forename: Ruoheng
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors.forename: Jiatong
authors.initials: J
authors.lastname: Li
authors.affiliation: Clinical Laboratory, Guangxi Liuzhou Worker's Hospital, Liuzhou, Guangxi, 545005, China.
authors.forename: Xiaomou
authors.initials: X
authors.lastname: Wei
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors.forename: Yuening
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442001, China.
authors.forename: Chengdong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors.forename: Feifan
authors.initials: F
authors.lastname: Xiao
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors.forename: Xuandong
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Cell Biology and Genetics, School of Premedical Sciences, Guangxi Medical University, Nanning, Guangxi, 530021, China. wuhuayu0418@hotmail.com.
authors.forename: Huayu
authors.initials: H
authors.lastname: Wu
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China. cncsyxl@126.com.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yang
mesh_terms: D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D059811:HLA-DRB1 Chains
keywords: Allele; Ethnic groups; HLA-DRB1; Meta-analysis; Nasopharyngeal carcinoma; Polymorphisms