title: New clerodane diterpenoids from the roots of Polyalthia laui.
abstract: Five new clerodane diterpenoids, polylauiester A (1), (4→2)-abeo-2,13-diformyl-cleroda-2,12E-dien-14-oic acid (2) and polylauiamides B-D (3-5), together with 11 known clerodane diterpenoids (6-16), were isolated from the roots of Polyalthia laui. Among them, polylauiester A (1) represents the first example of a novel norclerodane diterpenoid only containing 17 carbon atoms on the carbon skeleton, and polylauiamide B (3) is an unusual diterpenoid with a p-substituted benzene ring as a substituent. Their structures were elucidated by extensive spectroscopic methods, and the relative configuration of polylauiamide B (3) was further confirmed by the single crystal X-ray diffraction method. Biological evaluation of new compounds against human Hela, MCF-7 and A549 human cancer cell lines showed that all compounds displayed weak cytotoxicities against various human cancer cell lines in the range of IC50 at 25.01-39.31μM.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
authors.forename: Zhang-Xin
authors.initials: ZX
authors.lastname: Yu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Fu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China. Electronic address: sxp628@126.com.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China. Electronic address: hchr116@126.com.
authors.forename: Chang-Ri
authors.initials: CR
authors.lastname: Han
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
authors.forename: Xiao-Bao
authors.initials: XB
authors.lastname: Li
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
authors.forename: Xin-Ming
authors.initials: XM
authors.lastname: Song
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
authors.forename: Ai-Zhen
authors.initials: AZ
authors.lastname: Wu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
authors.forename: Shi-Chen
authors.initials: SC
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D031044:Polyalthia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D010936:Plant Extracts; C000613361:polylauiamide B; C000613360:polylauiester A
keywords: Clerodane diterpenoids; Cytotoxicity; Polyalthia laui; Polylauiamides B–D; Polylauiester A