title: Disruption of evasive immune cell microenvironment in tumors reflects immunity induced by radiation therapy.
abstract: Radiation administered to murine colon tumors induced durable remissions that were dependent on CD4+and CD8+T cell immunity, and antigen cross priming CD8+dendritic cells (DCs). Remissions were associated with marked reductions in the infiltration of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and Treg cells, and a marked increase in CD8+T cells.
authors.affiliation: Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine , Stanford, CA, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Filatenkov
authors.affiliation: Division of Blood and Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine , Stanford, CA, USA.
authors.forename: Jeanette
authors.initials: J
authors.lastname: Baker
authors.affiliation: Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine , Stanford, CA, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Strober
keywords:  tumor immunity; CD8 T cells; colon tumors; radiation therapy; tumor microenvironment