title: Tryptophan Hydroxylase 1 Variant rs1800532 is Associated with Suicide Attempt in Serbian Psychiatric Patients but does not Moderate the Effect of Recent Stressful Life Events.
abstract: Tryptophan hydroxylase 1 (TPH1) gene, coding for serotonin synthesizing enzyme, and recent stressful life events (SLEs) have been commonly associated with suicidal behavior. TPH1 has been also hypothesized to be involved in stress-response mechanisms. The aim of this study was to assess TPH1 variant rs1800532 and its possible interaction with recent SLEs as risk factors for suicide attempt (SA) in Serbian psychiatric patients, including 165 suicide attempters and 188 suicide nonattempters. rs1800532 and recent SLEs were independently associated with SA, while rs1800532 did not moderate the effect of recent SLEs on SA vulnerability among Serbian psychiatric patients.
authors.affiliation: Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Karanović
authors.affiliation: Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia.|Medical School, University of Belgrade, Belgrade, Serbia.
authors.forename: Maja
authors.initials: M
authors.lastname: Ivković
authors.affiliation: Department of Genetic Research, Institute for Biological Research "Siniša Stanković", University of Belgrade, Belgrade, Serbia.
authors.forename: Vladimir M
authors.initials: VM
authors.lastname: Jovanović
authors.affiliation: Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: Maja
authors.initials: M
authors.lastname: Pantović
authors.affiliation: Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Pavlović-Janković
authors.affiliation: Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia.|Medical School, University of Belgrade, Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Damjanović
authors.affiliation: Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
authors.forename: Goran
authors.initials: G
authors.lastname: Brajušković
authors.affiliation: Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
authors.forename: Stanka
authors.initials: S
authors.lastname: Romac
authors.affiliation: Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
authors.forename: Dušanka
authors.initials: D
authors.lastname: Savić-Pavićević
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D012307:Risk Factors; D055771:Serbia / Q000453:epidemiology; D013406:Suicide, Attempted; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: C497467:TPH1 protein, human; D014365:Tryptophan Hydroxylase