title: Fatal liver cyst rupture in polycystic liver disease complicated with autosomal dominant polycystic kidney disease: A case report.
abstract: A 59-year-old man was struck in the abdomen and later presented to the emergency room. His blood pressure dropped and eventually died 16h post trauma and just before emergency exploratory laparotomy. Autopsy revealed two polycystic kidneys and a giant polycystic liver with two ruptures. Blood (2225g) was observed in the peritoneum and the body-surface injury was minor. Genetic testing was performed to confirm that the man had an autosomal dominant polycystic kidney disease (ADPKD) complicated by polycystic liver disease (PLD). Autopsy, histopathology and medical history showed that the cause of death was the ruptures of liver cysts due to trauma. In this communication, we describe a fatal case and hope to increase awareness and recognition of PLD and ADPKD. We also wish to indicate that due to the fragile condition of liver cysts, trauma should be considered even if the body-surface injury is minor in fatal cases of PLD patient with a traumatic history.
authors.affiliation: Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: fytongfang@gmail.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Tong
authors.affiliation: Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: yueyueashin@gmail.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: lyre2008@126.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: 18707165089@163.com.
authors.forename: Wenhe
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China. Electronic address: 276538406@qq.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: gerichtsarzt@hotmail.com.
authors.forename: Yijie
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: zhouyiwu@outlook.com.
authors.forename: Yiwu
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000007:Abdominal Injuries / Q000150:complications*; D003560:Cysts / Q000473:pathology*; D017809:Fatal Outcome; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010537:Peritoneum / Q000473:pathology; D016891:Polycystic Kidney, Autosomal Dominant / Q000473:pathology*; D012421:Rupture / Q000209:etiology*
keywords: Autosomal dominant polycystic kidney disease; Forensic pathology; Genetic analysis; Polycystic liver disease