title: [Seronegative celiac disease: A case report].
abstract: The paper describes a rare case of celiac disease in the absence of serum anti-tissue transglutaminase (anti-tTG) antibodies. A 51-year-old patient has been suffering from diarrheas for 20 years. He has lost 15 kg gradually; weakness progressed; muscle cramps, leg edemas, and signs of dynamic pseudoobstruction appeared. Morphological examination revealed small intestinal mucosal (SIM) villous atrophy (Marsh IIIC stage). IgA anti-tTG and IgG anti-tTG antibodies were 0.086 and 0.178, respectively. The patient was prescribed a gluten-free diet, water electrolyte solutions to correct metabolic disturbances, and prednisolone. During a control examination after 6 months, the patient had no complaints and gained 22 kg, and the SIM villus height was increased. The specific feature of the case is specific negative serological tests for celiac disease.
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Krums
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Parfenov
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Sabelnikova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Poleva
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Bykova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Dubtsova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: R B
authors.initials: RB
authors.lastname: Gudkova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Khomeriki
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: D L
authors.initials: DL
authors.lastname: Rotin
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Pavlov
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: N S
authors.initials: NS
authors.lastname: Starostina
mesh_terms: D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D055050:Diet, Gluten-Free / Q000379:methods*; D005440:Fluid Therapy / Q000379:methods*; D019204:GTP-Binding Proteins / Q000276:immunology*; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007108:Immune Tolerance; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology / Q000503:physiopathology; D008297:Male; D044342:Malnutrition / Q000209:etiology / Q000503:physiopathology; D008875:Middle Aged; D009120:Muscle Cramp / Q000209:etiology / Q000503:physiopathology; D011239:Prednisolone / Q000008:administration & dosage*; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology*; D016896:Treatment Outcome; D014883:Water-Electrolyte Imbalance / Q000209:etiology / Q000628:therapy; D015431:Weight Loss
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins