title: Neural Mechanisms Contributing to Dysphagia in Mouse Models.
abstract: Investigative research into curative treatments for dysphagia is hindered by our incomplete understanding of the neural mechanisms of swallowing in health and disease. Development of translational research models is essential to bridge this knowledge gap by fostering innovative methodology. Toward this goal, our laboratory has developed a translational research assessment tool to investigate the neural mechanistic control of swallowing in unrestrained, self-feeding mice. Here we describe our initial development of synchronous brainstem neural recordings with a videofluoroscopic swallow study assay in healthy mice across the life span. Refinement of this combined methodology is currently underway. Ultimately, we envision that this assessment tool will permit systematic analysis of therapeutic interventions for dysphagia in preclinical trials with numerous mouse models of human conditions that cause dysphagia, such as amyotrophic lateral sclerosis, Parkinson's disease, stroke, and advanced aging.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA.
authors.forename: Cameron J
authors.initials: CJ
authors.lastname: Hinkel
authors.affiliation: Department of Neurology, University of Missouri School of Medicine, Columbia, Missouri, USA.
authors.forename: Rishi
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Department of Neurology, University of Missouri School of Medicine, Columbia, Missouri, USA.
authors.forename: Mahesh M
authors.initials: MM
authors.lastname: Thakkar
authors.affiliation: Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, USA.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA.
authors.forename: Bridget L
authors.initials: BL
authors.lastname: Hopewell
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA levert@health.missouri.edu.
authors.forename: Teresa E
authors.initials: TE
authors.lastname: Lever
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D003680:Deglutition Disorders / Q000503:physiopathology*; D004195:Disease Models, Animal; D004594:Electrophysiology; D005471:Fluoroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D057170:Translational Research, Biomedical; D014741:Video Recording
keywords: dysphagia; electrophysiology; mice; swallowing; translational research; videofluoroscopy