title: 25-OH-Vitamin D Is Not Associated with Cognitive Performance among Mexican Community-Dwelling Older Persons.
abstract: BACKGROUND
  Low cognitive performance has been associated with a wide array of adverse health-related outcomes in elderly populations. Recently, the effect of vitamin D on cognition has been studied; however, its benefits are still controversial. Moreover, most studies have been carried out on North-American and European populations where vitamin D deficiency could represent a greater public-health issue when compared to Latin American ones.
  
  
  OBJECTIVE
  To investigate the association between 25-OH-vitamin D and cognitive performance in Mexican community-dwelling elderly.
  
  
  METHODS
  Cross-sectional study sample of 331 community-dwelling elderly aged 70 and older, participating in the Mexican Study of Nutritional and Psychosocial Markers of Frailty.
  
  
  METHODS
  Serum 25-OH-vitamin D, cognitive performance as per the Mini-Mental State Examination (MMSE) and the IST (Isaacs Set Test), as well as several elements from the comprehensive geriatric assessment.
  
  
  RESULTS
  Mean age of participants was 79.3 years (SD 5.9), 54.1% were women. The mean serum 25-OH-vitamin D level was 59.0 (SD 23.3) nmol/L while mean MMSE score was 22.3 (SD 3.4) and mean IST score was 37.1 (SD 9.1). Although 25-OH-vitamin D levels were lower across all the definitions of low cognitive perfomance, the difference between groups was not statistically significant in any of them.
  
  
  CONCLUSIONS
  No association between 25-OH-vitamin D level and cognitive performance was found in this population of Mexican community-dwelling elderly. Further investigation is required in order to clarify its existence and if so, to delineate its characteristics.
authors.affiliation: José Alberto Ávila-Funes. Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15. CP 14000; Tlalpan, Distrito Federal, México. Phone: +52(55)54 87 09 00, 5703. E-mail: avilafunes@live.com.mx.
authors.forename: A P
authors.initials: AP
authors.lastname: Navarrete-Reyes
authors.forename: I
authors.initials: I
authors.lastname: García-Muñoz
authors.forename: J M A
authors.initials: JM
authors.lastname: García-Lara
authors.forename: N M
authors.initials: NM
authors.lastname: Torres-Carrillo
authors.forename: H
authors.initials: H
authors.lastname: Amieva
authors.forename: J A
authors.initials: JA
authors.lastname: Avila-Funes