title: Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats.
abstract: This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may contribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning.
authors.affiliation: Military Medical Center "Karaburma", 11000 Belgrade, Serbia.
authors.forename: Bratislav
authors.initials: B
authors.lastname: Dejanovic
authors.affiliation: Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Stevanovic
authors.affiliation: Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Ninkovic
authors.affiliation: Institute for Biochemistry, Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Stojanovic
authors.affiliation: Institute for Biological Research "Sinisa Stankovic", University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Irena
authors.initials: I
authors.lastname: Lavrnja
authors.affiliation: Institute of Meat Hygiene and Technology, 11000 Belgrade, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Radicevic
authors.affiliation: Department of Obstetrics, Faculty of Veterinary Medicine, 11000 Belgrade, Serbia.
authors.forename: Milos
authors.initials: M
authors.lastname: Pavlovic
mesh_terms: D000376:Agmatine / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002746:Chlorpromazine / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects*; D016548:Prosencephalon / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D000376:Agmatine; D002746:Chlorpromazine
keywords: agmatine; antioxidant defense; astrocytes; chlorpromazine; oxidative stress