title: Circulating miR155 expression level is positive with blood pressure parameters: Potential markers of target-organ damage.
abstract: OBJECTIVE
  The aim of this study is to evaluate the relationship of miR155 with office and ambulatory blood pressure (BP) parameters and left ventricular hypertrophy (LVH) in patients with hypertension and healthy controls.
  
  
  METHODS
  We assessed the expression level of the miR155 in 50 patients with essential hypertension and 30 healthy individuals. All patients underwent two-dimensional echocardiography, office BP monitoring and ambulatory blood pressure monitoring (ABPM). Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was used to evaluate the expression of selected miR155. The miR155 correlations between BP parameters and left ventricular mass index (LVMI) were assessed using the Spearman correlation coefficient.
  
  
  RESULTS
  We observed higher expression level of miR155 (33.22 ± 2.59 vs. 27.30 ± 1.76; p < 0.001) in hypertensive patients compared with healthy control individuals, as well as in LVH to nLVH group (33.00 ± 2.78 vs. 27.28 ± 1.76; p < 0.001). MiR155 expression level showed significant positive correlations with office measurement of systolic blood pressure (SBP) (r = 0.634, p < 0.001), diastolic blood pressure (DBP) (r = 0.222, p < 0.05), pulse pressure (PP) (r = 0.564, p < 0.001), respectively. And explored miR155 expression level in relation to 24-h ABPM parameters showed significant positive correlation with 24 h mean SBP (r = 0.67, p < 0.001), 24 h mean DBP (r = 0.257, p < 0.05), 24 h mean PP (r = 0.597, p < 0.001), respectively, as well as with LVMI (r = 0.591, p < 0.001).
  
  
  CONCLUSIONS
  Circulating miR155 may possibly represent potential non-invasive marker of hypertension and target organ damage (TOD) in essential hypertensive patients.
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Huang
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Jiyan
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Yingling
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: b Community Health Center of Liaobu County , Donguang , Guangdong , China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Tang
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Xueju
authors.initials: X
authors.lastname: Yu
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Mo
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.
authors.forename: Yingqing
authors.initials: Y
authors.lastname: Feng
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D002681:China; D004452:Echocardiography / Q000379:methods; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; C524942:MIRN155 microRNA, human; D035683:MicroRNAs
keywords: Essential hypertension; left ventricular hypertrophy; miR155