title: Intrathecal or intraventricular colistin: a review.
abstract: Central Nervous System (CNS) infections related to external ventricular derivation are a major complication of patients undergoing neurosurgical procedures. Antimicrobial treatment of CNS infections should be based not only on the susceptibility of the isolated microorganism, but also on the treatment's pharmacokinetic properties demonstrating the passage of the molecule through the blood-brain barrier. When CNS infections are caused by multi-drug resistant Gram-negative bacteria, intrathecal colistin is considered an effective and safe option. We review the literature of intrathecal/intraventricular use of colistin, comprehensive of both pharmacokinetic data and clinical experiences.
authors.affiliation: Infectious Diseases Section, Maggiore della Carità Hospital, Novara, Italy.
authors.forename: Olivia
authors.initials: O
authors.lastname: Bargiacchi
authors.affiliation: Department of Medical Sciences, University of Turin, Infectious Diseases Section at Amedeo di Savoia Hospital, Turin, Italy.
authors.forename: Francesco Giuseppe
authors.initials: FG
authors.lastname: De Rosa
mesh_terms: D000151:Acinetobacter Infections / Q000150:complications / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002494:Central Nervous System Infections / Q000188:drug therapy* / Q000382:microbiology; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D003091:Colistin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D006801:Humans; D007276:Injections, Intraventricular / Q000379:methods; D007278:Injections, Spinal / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin