title: Self-Rated Depression Severity Relative to Clinician-Rated Depression Severity: Trait Stability and Potential Role in Familial Transmission of Suicidal Behavior.
abstract: Self-rated depression and hopelessness severity are predictors of suicide attempt in major depression. This study evaluated whether: (1) greater self-rated distress relative to severity of clinician-rated depression is a trait; (2) that trait is familial; and (3) that trait is linked to familial transmission of suicidal behavior. A total of 285 mood disorder probands and 457 offspring were assessed twice, at least 1 year apart. Family and subject intra-class correlations for self-report depression and hopelessness, controlling for clinician-rated depression severity, were computed. Mixed general linear models determined offspring-proband correlations. Within-individual intra-class correlation (ICC) for depression-hopelessness was 37.8% (bootstrap 95% CI: 31.0-46.3%). Parent-offspring ICC was 10.7% (bootstrap 95% CI: 3.5-17.8%). Suicide attempt concordant parent-offspring correlation for subjective depression was positive, but negative for attempter parent and nonattempter offspring (p = .0213 for slope interaction). Pessimism was greater in proband or offspring attempters than proband or offspring nonattempters (p < .05). Self-reported hopelessness is partly trait-dependent, and there is modest familial transmission of self-reported depression linked to suicidal behavior that may partly explain familial transmission of suicidal behavior.
authors.forename: J
authors.initials: J
authors.lastname: John Mann
authors.forename: Steven P
authors.initials: SP
authors.lastname: Ellis
authors.forename: Dianne
authors.initials: D
authors.lastname: Currier
authors.forename: Jamie
authors.initials: J
authors.lastname: Zelazny
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.forename: Maria A
authors.initials: MA
authors.lastname: Oquendo
authors.forename: David J
authors.initials: DJ
authors.lastname: Kolko
authors.forename: Barbara
authors.initials: B
authors.lastname: Stanley
authors.forename: Nadine
authors.initials: N
authors.lastname: Melhem
authors.forename: Ainsley K
authors.initials: AK
authors.lastname: Burke
authors.forename: David A
authors.initials: DA
authors.lastname: Brent
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology / Q000706:statistics & numerical data; D003198:Computer Simulation; D003865:Major Depressive Disorder / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D004198:Disease Susceptibility; D005192:Family Health / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking / Q000379:methods / Q000706:statistics & numerical data; D010290:Parents / Q000523:psychology*; D000067657:Pessimism / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012647:Self-Assessment; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data
keywords: diathesis; linkage; major depression; pessimism; suicide attempts