title: Serotype-Specific Cell-Mediated Immunity Associated With Clearance of Homotypic Group B Streptococcus Rectovaginal Colonization in Pregnant Women.
abstract: We investigated the association between group B Streptococcus (GBS) serotype-specific capsular polysaccharide cellular immunity, measured with enzyme-linked immunospot (ELISPOT) interferon γ release assay at 20 weeks gestation in pregnant women, and its effect on rectovaginal serotype-specific GBS colonization up to 37 weeks gestation. Among women colonized by serotype III at enrollment, interferon γ ELISPOT positivity was more common in those in whom colonization was cleared (44.4%) than in those in whom colonization persisted (7.4%; P = .008), with a similar trend observed for serotype Ia. Presence of serotype-specific capsular polysaccharide cell-mediated immunity contributes to the clearance of GBS rectovaginal colonization.
authors.affiliation: Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kwatra
authors.affiliation: Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.
authors.forename: Peter V
authors.initials: PV
authors.lastname: Adrian
authors.affiliation: Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.
authors.forename: Tinevimbo
authors.initials: T
authors.lastname: Shiri
authors.affiliation: Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.
authors.forename: Alane
authors.initials: A
authors.lastname: Izu
authors.affiliation: Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.
authors.forename: Clare L
authors.initials: CL
authors.lastname: Cutland
authors.affiliation: Department of Obstetrics and Gynecology, University of the Witwatersrand.
authors.forename: Eckhart J
authors.initials: EJ
authors.lastname: Buchmann
authors.affiliation: Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
authors.forename: Shabir A
authors.initials: SA
authors.lastname: Madhi
mesh_terms: D000293:Adolescent; D000328:Adult; D001422:Bacterial Adhesion; D058501:Enzyme-Linked Immunospot Assay; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008875:Middle Aged; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000382:microbiology; D012007:Rectum / Q000382:microbiology; D065288:Serogroup; D013290:Streptococcal Infections / Q000276:immunology* / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000145:classification / Q000276:immunology*; D014621:Vagina / Q000382:microbiology; D055815:Young Adult
chemical_list: D011135:Polysaccharides, Bacterial
keywords: cellular immunity; colonization; group B Streptococcus