title: The association of serum cathepsin B concentration with age-related cardiovascular-renal subclinical state in a healthy Chinese population.
abstract: Cathepsin B (CTSB) is an important enzyme for many physiological and pathological processes, and its activity increases with age. Here, we explored the association between serum CTSB and aging-related subclinical cardiovascular and renal status in a healthy Chinese population.
  
  
  
  The study included 369 healthy individuals aged 36-87 years. Cardiovascular structure and function were assessed by the left ventricular ejection fraction, the early-diastolic peak flow velocity to late-diastolic peak flow velocity ratio at the mitral leaflet tips, carotid intima-media thickness (IMT), the diameter of the bilateral common carotid artery (D), and blood systolic peak (SPV) and end diastolic velocities, which were measured by M-mode ultrasonography. Serum CTSB, insulin-like growth factor-1 (IGF-1), 1, 25-dihydroxy vitamin D3, and parathyroid hormone (PTH) were measured by enzyme-linked immunosorbent assay.
  
  
  
  In men, serum CTSB was significantly related to IMT and IMT/D in the unadjusted model, and these associations were lost after age adjustment. In women, serum CTSB remained significantly associated with serum creatinine (SCr) (p=0.009), estimated glomerular filtration rate (p=0.048) and IMT/D (p=0.017) following full adjustment. PTH was independently associated with SCr. IGF-1 was significantly associated with SPV in women. CTSB was correlated with metabolic and endocrine biomarkers.
  
  
  
  Serum CTSB was associated with aging-related cardiovascular-renal parameters even in healthy people. Measurement of serum CTSB alone or in combination with metabolic and endocrine biomarkers can provide valuable information for predicting cardiovascular-renal function in healthy people, especially in elderly women.
authors.affiliation: Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: xiaojuan.bai@163.com.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Bai
authors.affiliation: Department of Gerontology and Geriatrics, The Second Hospital of Dalian Medical University, Dalian, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
authors.affiliation: Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Kidney, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Kidney, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D002401:Cathepsin B / Q000097:blood*; D002681:China; D003326:Coronary Circulation; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D003404:Creatinine; D002401:Cathepsin B
keywords: Age; CTSB; Cardiovascular; Renal; Subclinical-state