title: Surgical Sutures with Porous Sheaths for the Sustained Release of Growth Factors.
abstract: Surgical sutures with highly porous sheaths are developed using a swelling and freeze-drying procedure without compromising their mechanical properties. The modified sutures show a high capacity for loading biofactors and are able to release the loaded biofactors in a sustained manner.
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.|State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong, 250100, P. R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.|Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, 63130, USA.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Linderman
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong, 250100, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Orthopedic Surgery, Columbia University, New York, NY, 10032, USA.|Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
authors.forename: Stavros
authors.initials: S
authors.lastname: Thomopoulos
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.|School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.|School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D065546:Drug Liberation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D016062:Porosity; D013537:Sutures
chemical_list: D003692:Delayed-Action Preparations; D036341:Intercellular Signaling Peptides and Proteins
keywords: drug delivery; sustained release; suture; tendon repair