title: Bombesin-Like Receptor 3: Physiology of a Functional Orphan.
abstract: Bombesin-like receptor 3 (BRS-3) is an X-linked orphan Gq-coupled receptor that regulates food intake, metabolic rate, body temperature, heart rate, blood pressure, and insulin secretion. Most BRS-3 actions occur via the brain, through mechanisms including regulating sympathetic outflow. Ablation of Brs3 causes obesity, while synthetic agonists produce weight loss.
authors.affiliation: Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
authors.forename: Cuiying
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address: marc.reitman@nih.gov.
authors.forename: Marc L
authors.initials: ML
authors.lastname: Reitman
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D004435:Eating / Q000235:genetics / Q000502:physiology; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology; D006339:Heart Rate / Q000235:genetics / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D018004:Receptors, Bombesin / Q000235:genetics / Q000378:metabolism*
chemical_list: D007328:Insulin; D018004:Receptors, Bombesin; C107120:bombesin receptor subtype 3
keywords: blood pressure; energy expenditure; food intake; heart rate; insulin secretion; sympathetic tone