title: The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study.
abstract: BACKGROUND
  Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus.
  
  
  METHODS
  The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years.
  
  
  RESULTS
  The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma.
  
  
  CONCLUSIONS
  Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin.
authors.affiliation: Faculty of Medicine, Catedrático José Serrano, 33006, Oviedo, Spain, mjgarcia@uniovi.es.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Garcia-Pola
authors.forename: S
authors.initials: S
authors.lastname: Llorente-Pendás
authors.forename: M
authors.initials: M
authors.lastname: González-Garcia
authors.forename: J-M
authors.initials: JM
authors.lastname: García-Martín
mesh_terms: D018289:Carcinoma, Verrucous; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000150:complications*; D017676:Lichen Planus, Oral / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms