title: Phenylene vinylene macrocycles as artificial transmembrane transporters.
abstract: A series of rigid phenylene vinylene macrocycles and phenylene ethynylene macrocycles with various substituents have been investigated as transmembrane ion channels. The length and polarity of the substituents have a significant effect on the ion channel formation and the mass transport efficiency. Macrocycles with strong aggregation facilitate ion passage across lipid bilayers.
authors.affiliation: Key Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun 130022, P. R. China. liu_zhenning@jlu.edu.cn.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Hu
authors.forename: Chao
authors.initials: C
authors.lastname: Yu
authors.forename: Kenji
authors.initials: K
authors.lastname: D Okochi
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Jin
authors.forename: Zhenning
authors.initials: Z
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001190:Arylsulfonates / Q000737:chemistry; D055459:Facilitated Diffusion; D005452:Fluoresceins / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007476:Ionophores / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D012965:Sodium Chloride / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry*; D053835:Unilamellar Liposomes / Q000737:chemistry
chemical_list: D000480:Alkynes; D001190:Arylsulfonates; D005452:Fluoresceins; D005456:Fluorescent Dyes; D007476:Ionophores; D047028:Macrocyclic Compounds; D013267:Stilbenes; D053835:Unilamellar Liposomes; D012965:Sodium Chloride; C005047:pyranine; C007740:fluorexon