title: The influence of Omega3 fatty acids supplementation against aluminum-induced toxicity in male albino rats.
abstract: This study evaluated the protective and antioxidant potential of Omega3 fatty acids (FAs) against aluminum intoxicated male albino rats. Twenty-four male albino rats were divided into four equal groups: group I served as control; group II (Omega3-treated) received Omega3 FAs 1000 mg/kg bwt/day orally; group III (aluminum-treated) received aluminum chloride 100 mg/kg bwt/day orally and group IV (aluminum + Omega3-treated) received aluminum chloride 100 mg/kg bwt/day and Omega3 FAs 1000 mg/kg bwt/day orally. Treatments lasted for 4 weeks. Results indicate that administration of aluminum chloride showed non-significant changes in serum alanine aminotransferase, urea, and creatinine levels, a significant increase in serum aspartate aminotransferase and malondialdehyde as well as a significant reduction in serum-reduced glutathione levels. Aluminum treatment induced histopathological alterations in the liver, kidney, brain, testes, and epididymis. Omega3 FAs supplementation improved the serum parameters, enhanced endogenous antioxidant status, reduced lipid peroxidation, and ameliorated the intensity of the histopathological lesions. These findings reveal that Omega3 FAs supplementation can lighten the toxic effects of aluminum through their antioxidant and free radical-scavenging effects.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, P.O. Box. 22758, Edfina-Rashid-Behera, Egypt. samahoda@yahoo.com.
authors.forename: Samah S
authors.initials: SS
authors.lastname: Oda
mesh_terms: D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D018675:Toxicity Tests
chemical_list: D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D000535:Aluminum
keywords: Aluminum; Antioxidant; Histopathology; Omega3 fatty acids; Oxidative status