title: Sinusoidal obstruction syndrome.
abstract: Sinusoidal obstruction syndrome (SOS) is characterized by damage to small hepatic vessels affecting particularly sinusoidal endothelium. Damaged sinusoids can be associated with a partial or complete occlusion of small hepatic veins, hence the previous denomination of hepatic veno-occlusive disease (VOD). Exposure to certain exogenous toxins appears to be specific to this condition and is frequently included in its definition. Typical histopathological features of SOS in a liver biopsy specimen are presented in the text. The purpose of this article is to provide an overview on the different entities corresponding to this general definition. Such entities include: (i) liver disease related to pyrrolizidine alcaloids; (ii) liver injury related to conditioning for hematopoietic stem cell transplantation; (iii) vascular liver disease occurring in patients treated with chemotherapy for liver metastasis of colorectal cancer; and (iv) other liver diseases related to toxic agents.
authors.affiliation: Département hospitalo-universitaire UNITY, 92118 Clichy, France; Service d'hépatologie, hôpital Beaujon, AP-HP, 100, boulevard Leclerc, 92118 Clichy, France; CRI, UMR1149, université Paris Diderot and Inserm, Paris, France. Electronic address: dominique.valla@bjn.aphp.fr.
authors.forename: Dominique-Charles
authors.initials: DC
authors.lastname: Valla
authors.affiliation: Département hospitalo-universitaire UNITY, 92118 Clichy, France; Département de pathologie, hôpital Beaujon, AP-HP, Clichy, France; CRI, UMR1149, université Paris Diderot and Inserm, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Cazals-Hatem
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D011763:Pyrrolizidine Alkaloids / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D011763:Pyrrolizidine Alkaloids