title: Sec14-like phosphatidylinositol transfer proteins and the biological landscape of phosphoinositide signaling in plants.
abstract: Phosphoinositides and soluble inositol phosphates are essential components of a complex intracellular chemical code that regulates major aspects of lipid signaling in eukaryotes. These involvements span a broad array of biological outcomes and activities, and cells are faced with the problem of how to compartmentalize and organize these various signaling events into a coherent scheme. It is in the arena of how phosphoinositide signaling circuits are integrated and, and how phosphoinositide pools are functionally defined and channeled to privileged effectors, that phosphatidylinositol (PtdIns) transfer proteins (PITPs) are emerging as critical players. As plant systems offer some unique advantages and opportunities for study of these proteins, we discuss herein our perspectives regarding the progress made in plant systems regarding PITP function. We also suggest interesting prospects that plant systems hold for interrogating how PITPs work, particularly in multi-domain contexts, to diversify the biological outcomes for phosphoinositide signaling. This article is part of a Special Issue entitled: Plant Lipid Biology edited by Kent D. Chapman and Ivo Feussner.
authors.affiliation: Department of Molecular & Cellular Medicine, Texas A&M Health Sciences Center, College Station, TX 77843-1114 USA. Electronic address: huang@tamhsc.edu.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Molecular & Cellular Medicine, Texas A&M Health Sciences Center, College Station, TX 77843-1114 USA.
authors.forename: Ratna
authors.initials: R
authors.lastname: Ghosh
authors.affiliation: Department of Molecular & Cellular Medicine, Texas A&M Health Sciences Center, College Station, TX 77843-1114 USA; Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843-1114 USA; Department of Chemistry, Texas A&M University, College Station, TX 77843-1114 USA. Electronic address: vytas@tamhsc.edu.
authors.forename: Vytas A
authors.initials: VA
authors.lastname: Bankaitis
mesh_terms: D050356:Lipid Metabolism / Q000235:genetics*; D018129:Phosphatidylinositol Phosphates / Q000235:genetics / Q000378:metabolism; D010716:Phosphatidylinositols / Q000235:genetics* / Q000378:metabolism; D049294:Phospholipid Transfer Proteins / Q000235:genetics* / Q000378:metabolism; D010944:Plants / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D015398:Signal Transduction
chemical_list: D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D049294:Phospholipid Transfer Proteins; C483438:SEC14 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins
keywords: Phosphatidylinositol transfer proteins; Phosphoinositides; Sec14