title: Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740.
abstract: OBJECTIVE
  The aim of this work was to test whether three single nucleotide polymorphisms (SNPs) implicated in glutamate homoeostasis or signalling and cellular survival are associated with birth condition.
  
  
  METHODS
  This study is drawn from the Avon Longitudinal Study of Parents and Children. A total of 7611 term infants were genotyped and patient outcome data retrieved from routine medical records. Exposure measures were the presence of one or more minor alleles in one of 3 SNPs (rs2284411, rs2498804, rs1835740). The primary outcome was the need for resuscitation at birth.
  
  
  RESULTS
  For SNP rs1835740, infants homozygous for the minor allele compared to wild type were more likely to need resuscitation (9.2% vs. 7.0%, p = 0.041), while the odds ratio for resuscitation was associated with each increasing minor allele [OR 1.17 (1.01-1.35)]. Population attributable risk fraction was 6.5%. There was no evidence that the other two SNPs investigated were associated with birth condition.
  
  
  CONCLUSIONS
  We have tested three candidate SNPs to measure any association with birth condition. The study revealed that the rs1835740 was associated with the need for resuscitation and Apgar scores, with a substantial population impact.
authors.affiliation: North Bristol NHS Trust, Bristol, UK.
authors.forename: David
authors.initials: D
authors.lastname: Odd
authors.affiliation: Centre for Research in Biosciences, University of the West of England, Bristol, UK.
authors.forename: Anikó
authors.initials: A
authors.lastname: Váradi
authors.affiliation: Centre for Research in Biosciences, University of the West of England, Bristol, UK.
authors.forename: Shavanthi
authors.initials: S
authors.lastname: Rajatileka
authors.affiliation: Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
authors.forename: Elek
authors.initials: E
authors.lastname: Molnár
authors.affiliation: School of Clinical Sciences, University of Bristol, Bristol, UK.
authors.forename: Karen
authors.initials: K
authors.lastname: Luyt
mesh_terms: D001238:Asphyxia Neonatorum / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008565:Membrane Proteins; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D016601:RNA-Binding Proteins; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
chemical_list: D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D051057:Proto-Oncogene Proteins c-akt
keywords: Asphyxia neonatorum; Brain; Cohort studies; Glutamate; Hypoxia-Ischaemia; Polymorphism