title: Early Evidence of Impact of Monovalent Rotavirus Vaccine in Togo.
abstract: Togo introduced monovalent rotavirus vaccine starting 19 June 2014. We compared all-cause acute gastroenteritis (AGE) hospitalizations and rotavirus-associated hospitalizations during the prevaccine period (July 2008-June 2014) to 1 year after vaccine introduction (July 2014-June 2015). The proportion of children with AGE who tested positive for rotavirus declined from 53% (645/1223) in prevaccine years to 36% (68/187) in the postvaccine year (P< .01). The decline only occurred in children <1 year of age who were eligible for vaccination and was greatest during the rotavirus season months, supporting that it was associated with vaccine implementation.
authors.affiliation: Department of Paediatrics, Sylvanus Olympio Teaching Hospital of Lomé, Togo.
authors.forename: Enyonam
authors.initials: E
authors.lastname: Tsolenyanu
authors.affiliation: World Health Organization, Regional Office for Africa, Brazzaville, Congo.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Mwenda
authors.affiliation: Laboratory Department, Sylvanus Olympio Teaching Hospital of Lomé, Togo.
authors.forename: Anoumou
authors.initials: A
authors.lastname: Dagnra
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Eyal
authors.initials: E
authors.lastname: Leshem
authors.affiliation: Laboratory Department, Sylvanus Olympio Teaching Hospital of Lomé, Togo.
authors.forename: Mawussi
authors.initials: M
authors.lastname: Godonou
authors.affiliation: Expanded Programme on Immunization, Ministry of Health.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Nassoury
authors.affiliation: Immunization Focal Point, World Health Organization Country Office, Lomé, Togo.
authors.forename: Dadja
authors.initials: D
authors.lastname: Landoh
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
authors.affiliation: Department of Paediatrics, Sylvanus Olympio Teaching Hospital of Lomé, Togo.
authors.forename: Yawo
authors.initials: Y
authors.lastname: Atakouma
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000517:prevention & control* / Q000821:virology; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D012621:Seasons; D014037:Togo / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: C492457:RIX4414 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated
keywords: Togo; impact; monovalent rotavirus vaccine; rotavirus