title: Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinularia sp.
abstract: A new polyhydroxysterol, (22E)-24-methylenecholestane-22-ene-3β,5α,6β-triol (1), together with four known analogues (2-5) were isolated from the South China Sea soft coral Sinularia sp. Their structures were elucidated by spectroscopic analyses and comparison with previously reported data. All these compounds exhibited cytotoxic effect against both HepG2 and HeLa cell lines with IC50values ranging from 8.36 to 37.30 μM. Preliminary structure-activity relationship study identified that the presence of double bonds in the side chains of these polyhydroxysterols significantly reduced the biological effect obtained.
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R. China.
authors.forename: Huan
authors.initials: H
authors.lastname: Sun
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R. China.
authors.forename: Mei-Ran
authors.initials: MR
authors.lastname: Feng
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Peng
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R. China.
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Liao
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R. China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Liu
authors.affiliation: b College of Science and Engineering , Jinan University , Guangzhou , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou , P.R. China.
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xu
keywords:  sp.; Soft coral; cytotoxicity; sterols