title: Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome.
abstract: OBJECTIVE
  The aim of this study was to use an established model of vibration-induced injury to assess frequency-dependent changes in transcript expression in skin, artery, and nerve tissues.
  
  
  METHODS
  Transcript expression in tissues from control and vibration-exposed rats (4 h/day for 10 days at 62.5, 125, or 250 Hz; 49 m/s, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.
  
  
  RESULTS
  Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.
  
  
  CONCLUSIONS
  Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.
authors.affiliation: Engineering Controls and Technology Branch and Biostatistics and Epidemiology Branch (Waugh, Miller, Johnson, Dr Krajnak), and National Institute for Occupational Safety and Health, Morgantown, West Virginia (Drs Kashon, Li).
authors.forename: Stacey
authors.initials: S
authors.lastname: Waugh
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kashon
authors.forename: Shengqiao
authors.initials: S
authors.lastname: Li
authors.forename: Gerome R
authors.initials: GR
authors.lastname: Miller
authors.forename: Claud
authors.initials: C
authors.lastname: Johnson
authors.forename: Kristine
authors.initials: K
authors.lastname: Krajnak
mesh_terms: D000818:Animals; D001158:Arteries; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D019295:Computational Biology; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics; D004195:Disease Models, Animal; D053421:Hand-Arm Vibration Syndrome / Q000235:genetics* / Q000378:metabolism; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D010525:Peripheral Nerves; D012313:RNA / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000235:genetics*; D012867:Skin; D014158:Transcription, Genetic; D044767:Ubiquitin-Protein Ligases; D014732:Vibration / Q000009:adverse effects*
chemical_list: D012313:RNA; C480973:Brap protein, rat; D044767:Ubiquitin-Protein Ligases; D064007:Ataxia Telangiectasia Mutated Proteins; D051360:Cyclin-Dependent Kinase 5; C495907:Cdk5 protein, rat