title: Clinical, Histopathological and Therapeutical Analysis of Inferior Eyelid Basal Cell Carcinomas.
abstract: BACKGROUND
  Eyelids are very susceptible area for non-melanoma skin cancers; among that, basal cell carcinoma has the highest incidence (almost 90% of malignant eyelid tumors) and 50-60% of eyelid basal cell carcinomas appear on inferior eyelid.
  
  
  OBJECTIVE
  To analyze clinical features of inferior eyelid basal cell carcinoma and to determine the efficacy of surgical treatment with frozen sectioncontrolled margins and methods of primary reconstruction of defects.
  
  
  METHODS
  A review of medical records of cases with primary inferior eyelid basal cell carcinoma treated by surgical excision with urgent histopathology controlled margins by FS technique, doubled by paraffin examination from October 2011 to October 2014. After histopathology confirmation of tumor free margins, proper inferior eyelid reconstruction was performed.
  
  
  RESULTS
  The review resulted in 36 patients with 36 lesions analyzed by clinical, histopatological and therapeuticalaspectswith a mean follow-up of 20 months. All lesions were primary BCC affecting inferior eyelid. There were no recurrence in the follow-up period. Inferior eyelid reconstruction techniques were direct closure for small defects and complex techniques for defects more than one third of eyelid length.
  
  
  CONCLUSIONS
  Appropriate eyelid examination is mandatory in any routine ophthalmic check-up. Clinical signs suggestive of BCC should be familiar to ophthalmologist in order to have an early diagnosis and treatment for these tumors. Surgical treatment with FS controlled excision followed by eyelid reconstruction is an efficient treatment for inferior eyelid BCC.
  
  
  BACKGROUND
  basal cell carcinoma (BCC); frozen section (FS);Mohs micrographic surgery (MMS).
authors.affiliation: University Emergency Hospital Bucharest - Department of Clinical Ophthalmology; Regina Maria Private Health Care Network - Ophthalmology Department.
authors.forename: M
authors.initials: M
authors.lastname: Totir
authors.affiliation: University of Medicine and Pharmacy "Carol Davila" Bucharest, Romania - Ophthalmology Department.
authors.forename: C
authors.initials: C
authors.lastname: Alexandrescu
authors.affiliation: University of Medicine and Pharmacy "Carol Davila" Bucharest, Romania - Ophthalmology Department.
authors.forename: R
authors.initials: R
authors.lastname: Pirvulescu
authors.affiliation: University of Medicine and Pharmacy "Carol Davila" Bucharest, Romania - Ophthalmology Department; Regina Maria Private Health Care Network - Ophthalmology Department.
authors.forename: S
authors.initials: S
authors.lastname: Gradinaru
authors.affiliation: University Emergency Hospital Bucharest - Department of Anatomo-pathology.
authors.forename: M
authors.initials: M
authors.lastname: Costache
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000628:therapy*; D003710:Demography; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000628:therapy*; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: basal cell carcinoma; frozen section; histology; inferior eyelid