title: The efficiency of magnetic hyperthermia and in vivo histocompatibility for human-like collagen protein-coated magnetic nanoparticles.
abstract: Magnetic hyperthermia is a promising technique for the minimally invasive elimination of solid tumors. In this study, uniform magnetite nanoparticles (MNPs) with different particle sizes were used as a model system to investigate the size and surface effects of human-like collagen protein-coated MNPs (HLC-MNPs) on specific absorption rate and biocompatibility. It was found that these HLC-MNPs possess rapid heating capacity upon alternating magnetic field exposure compared to that of MNPs without HLC coating, irrespective of the size of MNPs. The significant enhancement of specific absorption rate is favorable for larger sized nanoparticles. Such behavior is attributed to the reduced aggregation and increased stability of the HLC-MNPs. By coating HLC on the surface of certain sized MNPs, a significant increase in cell viability (up to 2.5-fold) can be achieved. After subcutaneous injection of HLC-MNPs into the back of Kunming mice, it was observed that the inflammatory reaction hardly occurred in the injection site. However, there was a significant presence of phagocytes and endocytosis after the injection of nonconjugated counterparts. The overall strategy to fabricate HLC-MNPs can serve as a general guideline to address the current challenges in clinical magnetic hyperthermia, improved biocompatibility, and enhanced heating characteristics through protein coating.
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Le
authors.initials: L
authors.lastname: Chang
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China; Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, Singapore.
authors.forename: Xiao Li
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Dai
authors.initials: D
authors.lastname: Di Fan
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Yu Qing
authors.initials: YQ
authors.lastname: Miao
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: He Ping
authors.initials: HP
authors.lastname: Ma
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Qiu Ying
authors.initials: QY
authors.lastname: Liu
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Ma
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Wei Ming
authors.initials: WM
authors.lastname: Xue
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Yan E
authors.initials: YE
authors.lastname: Luo
authors.affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi, People's Republic of China; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Hai Ming
authors.initials: HM
authors.lastname: Fan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000737:chemistry / Q000494:pharmacology*; D006224:Cricetinae; D004705:Endocytosis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006979:Hyperthermia, Induced; D007249:Inflammation / Q000378:metabolism / Q000628:therapy*; D007668:Kidney / Q000166:cytology; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D010316:Particle Size
chemical_list: D058185:Magnetite Nanoparticles; D003094:Collagen
keywords: Fe3O4 nanoparticles; SAR value; biocompatibility; human-like collagen protein