title: SMITten by the Speed of Splicing.
abstract: Splicing occurs co-transcriptionally, but relative rates of splicing and transcription that might reveal mechanisms of their coordinated control have remained mysterious. Now, Carrillo Oesterreich et al. show that the fastest introns are gone nearly as soon as the 3' splice site is transcribed and that introns have distinct splicing kinetics with respect to polymerase progression along the gene.
authors.affiliation: Molecular, Cell, and Developmental Biology, Terasaki Life Sciences Building Room 5159, 610 Charles Young Drive East, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: tljohnson@ucla.edu.
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Johnson
authors.affiliation: Department of Molecular, Cell and Developmental Biology, Center for Molecular Biology of RNA, Sinsheimer Laboratories, 1156 High Street, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: ares@ucsc.edu.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ares
mesh_terms: D006801:Humans; D007438:Introns; D022821:RNA Splice Sites; D012326:RNA Splicing
chemical_list: D022821:RNA Splice Sites