title: An unusual sesquiterpene coumarin from the seeds of Ferula sinkiangensis.
abstract: A sesquiterpene coumarin, sinkiangenorin E, consisting of a novel bicyclo[4.3.1]decane-type sesquiterpene system, was isolated from the seeds of Ferula sinkiangensis. The structure of sinkiangenorin E including the relative stereochemistry and the absolute configuration was elucidated on the basis of spectroscopic data. The new compound showed cytotoxic activity against AGS cells (IC50, 12.7 μM) and inhibiting effect against influenza A H1N1 (IC50, 4.0 μM), which provided important clues for the study on the bioactivities of this type of sesquiterpene coumarins.
authors.affiliation: a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Li
authors.affiliation: a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
authors.forename: Jun-Chi
authors.initials: JC
authors.lastname: Wang
authors.affiliation: b Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica , Urumqi 830002 , China.
authors.forename: Xiao-Jin
authors.initials: XJ
authors.lastname: Li
authors.affiliation: a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.affiliation: a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.affiliation: a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
authors.forename: Na
authors.initials: N
authors.lastname: Lv
authors.affiliation: a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Si
mesh_terms: D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005309:Ferula / Q000737:chemistry*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C000613870:sinkiangenorin E; C030123:coumarin
keywords: Apiaceous; Ferula sinkiangensis; antiviral activity; cytotoxic activity; sesquiterpene coumarin