title: The relation between oxidative stress biomarkers and atrial fibrillation after pulmonary veins isolation.
abstract: The current paradigm claims a link between oxidative stress and atrial fibrillation. The aim of our research was to study a relation between the percentage of time spent in atrial fibrillation (AF burden) and concentrations of oxidative stress biomarkers, before and after pulmonary veins isolation (PVI).
  
  
  
  We included 19 patients (mean age 55±10years, 4 females and 15 males) with implanted loop recorders undergoing PVI. Plasmatic concentrations of advanced glycation end-products (AGEs), fructosamine, advanced oxidation protein products and thiobarbituric-acid reacting substances (TBARS) were measured and AF burden was recorded immediately before and 3months after the PVI. AF burden was also recorded 9months after the PVI.
  
  
  
  Post procedural AGEs concentration significantly negatively correlated with AF burden after 3months (ρ=-0.63; p<0.01) and 9months (ρ=-0.5; p=0.04), respectively as well as TBARS concentration significantly negatively correlated with AF burden after 9months (ρ=-0.61; p=0.01).
  
  
  
  Our study showed AGEs and TBARS to be potential predictors for AF burden after the PVI. We suppose that the more oxidative stress after the PVI is provoked, the more fibrotic tissue is produced. That means a better electrical isolation of pulmonary veins and consequently a lower AF burden.
authors.affiliation: National Institute of Cardiovascular Diseases, Bratislava, Slovakia; Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia. Electronic address: allan.bohm@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Böhm
authors.affiliation: Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors.forename: L
authors.initials: L
authors.lastname: Tothova
authors.affiliation: National Institute of Cardiovascular Diseases, Bratislava, Slovakia.
authors.forename: L
authors.initials: L
authors.lastname: Urban
authors.affiliation: Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors.forename: P
authors.initials: P
authors.lastname: Slezak
authors.affiliation: Faculty of Medicine, Comenius University, Bratislava, Slovakia; International Laser Center, Comenius University, Bratislava, Slovakia.
authors.forename: L
authors.initials: L
authors.lastname: Bacharova
authors.affiliation: Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
authors.forename: P
authors.initials: P
authors.lastname: Musil
authors.affiliation: National Institute of Cardiovascular Diseases, Bratislava, Slovakia; Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
authors.forename: R
authors.initials: R
authors.lastname: Hatala
mesh_terms: D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004562:Electrocardiography; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006329:Heart Conduction System / Q000601:surgery*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011379:Prognosis; D011667:Pulmonary Veins / Q000601:surgery*; D017382:Reactive Oxygen Species / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances
keywords: Atrial fibrillation; Implantable loop recorder; Oxidative stress biomarkers; Radiofrequency catheter ablation