title: Neuroblastoma arginine addiction subverts the anticancer immune response.
abstract: High-risk neuroblastoma continues to have a poor prognosis, stimulating the ongoing development of alternative immune-therapy approaches. Despite exciting preclinical results, clinical outcomes have been less clear. Recently we identified that neuroblastoma expresses Arginase II, depleting local and systemic arginine concentrations, and suppression of autologous and engineered T cell immunity.
authors.affiliation: School of Cancer Sciences, University of Birmingham , Birmingham, United Kingdom.
authors.forename: Carmela
authors.initials: C
authors.lastname: De Santo
authors.affiliation: School of Cancer Sciences, University of Birmingham , Birmingham, United Kingdom.
authors.forename: Francis
authors.initials: F
authors.lastname: Mussai