title: Reactivation tuberculosis: role of surveillance.
abstract: The incidence and death rates from tuberculosis (TB) have declined through concerted efforts in the diagnosis and treatment of active disease. Despite this, 9.6 million new cases and 1.1 million deaths in 2014 are unacceptably high. To decrease the rates of TB further, the huge number of persons with latent TB infection (LTBI) from whom new cases will arise has to be addressed with a sense of priority. Identifying the highest risk groups and providing effective treatment has been shown to decrease active TB. Further research to refine the predictors of reactivation and shorter effective treatments are urgently needed. Implementing intensified case finding, testing and treatment for LTBI will require continued investment in health care capacity at multiple levels.
authors.affiliation: a Global and Immigrant Health , Baylor College of Medicine , Houston , TX , USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: DiNardo
authors.affiliation: b Pulmonology, Department of Internal Medicine , Baylor College of Medicine , Houston , TX , USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Guy
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D006801:Humans; D055985:Latent Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D011159:Population Surveillance; D012307:Risk Factors; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents
keywords: HIV; Tuberculosis; intensive case finding; latent tuberculosis therapy; reactivation