title: Use your antibiotics wisely. Consequences to the intestinal microbiome.
abstract: Antibiotic therapy has long term consequences in the intestinal microbiome. Clostridium difficile has a well-known role in antibiotic-associated diarrhea, but in addition, persistent infection with this organism may increase the risk for developing inflammatory bowel disease. Here, recent literature on how the intestinal microbiome is altered by antibiotic therapy is presented.
authors.affiliation: Connecticut Children's Medical Center, Division of Infectious Diseases and Immunology, Hartford, CT 06106, USA Department of Pediatrics, UConn Health, Farmington, CT 06032, USA cervantes@uchc.edu.
authors.forename: Jorge
authors.initials: J
authors.lastname: Cervantes
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016360:Clostridioides difficile / Q000302:isolation & purification; D003015:Clostridium Infections / Q000382:microbiology / Q000517:prevention & control / Q000628:therapy; D003967:Diarrhea / Q000209:etiology / Q000382:microbiology; D064806:Dysbiosis / Q000209:etiology; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Clostridium difficile; antibiotic; inflammatory bowel disease; microbiome