title: Frequency-Specific Local Synchronization Changes in Paroxysmal Kinesigenic Dyskinesia.
abstract: The neurobiological basis of paroxysmal kinesigenic dyskinesia (PKD) is poorly defined due to the lack of reliable neuroimaging differences that can distinguish PKD with dystonia (PKD-D) from PKD with chorea (PKD-C). Consequently, diagnosis of PKD remains largely based on the clinical phenotype. Understanding the pathophysiology of PKD may facilitate discrimination between PKD-D and PKD-C, potentially contributing to more accurate diagnosis. We conducted resting-state functional magnetic resonance imaging on patients with PKD-D (n = 22), PKD-C (n = 10), and healthy controls (n = 32). Local synchronization was measured in all 3 groups via regional homogeneity (ReHo) and evaluated using receiver operator characteristic analysis to distinguish between PKD-C and PKD-D. Cortical-basal ganglia circuitry differed significantly between the 2 groups at a specific frequency. Furthermore, the PKD-D and PKD-C patients were observed to show different spontaneous brain activity in the right precuneus, right putamen, and right angular gyrus at the slow-5 frequency band (0.01-0.027 Hz). The frequency-specific abnormal local synchronization between the 2 types of PKD offers new insights into the pathophysiology of this disorder to some extent.
authors.affiliation: From the Department of Neurology (Z-RL, M-PD), the Second Affiliated Hospital of Medial College, Zhejiang University, Hangzhou, China; Center for Cognition and Brain Disorders and the Affiliated Hospital (H-HM, YY, WL), Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments (H-HM, YY, WL), Hangzhou, China; Mental Health Education and Counseling Center (YY), Zhejiang University, Hangzhou, China; and Center for Information in BioMedicine (WL), Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Liu
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Miao
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Ding
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D004421:Dystonia / Q000145:classification* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D055815:Young Adult