title: Clinicopathological Correlation Study of Oral Squamous Cell Carcinoma in a Local Indian Population.
abstract: BACKGROUND
  Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, shows geographical variation with respect to the age, sex, site and habits of the population. The histolopathologic grade of the tumor is closely related to its tissue of origin. This study was conducted to establish the prevalence of OSCC in relation to patient sex, age, habits and sites of lesions.
  
  
  METHODS
  A total of 130 cases of histopathologically diagnosed OSCC were selected for the study, out of which 66, 38 and 26 were well (WD), moderately (MD)and poorly differentiated (PD), respectively. Sections were stained with haematoxylin and eosin and graded according to a modified Borders's system. Then statistically analyzed different grades of OSCC for correlations with other variables.
  
  
  RESULTS
  In our study the majority cases of OSCC were found in the 5th to 7th decades of life, males acconting for 53%. The most common site was the buccal mucosa and most cases had habit of tobacco use either in the form of chewing or smoking or both. When the different grades of OSCC were compared with different sites a statistically significant value was observed (P=0.029).
  
  
  CONCLUSIONS
  The incidence of high grade PD is very much less in female patients but in males such lesions were common. In our location population the buccal mucosa is the most common site due to the tobbaco habits of the patients and majority cases of the buccal mucosa are WD whereas in tongue, floor of the mouth and palate PD are common.
authors.affiliation: Oral and Maxillofacial Pathology, KVG Dental College and Hospital, Sullia, India E-mail : hrishrai@gmail.com.
authors.forename: Harish Chandra
authors.initials: HC
authors.lastname: Rai
authors.forename: Junaid
authors.initials: J
authors.lastname: Ahmed
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014029:Tobacco Use Disorder / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D047368:Tumor Burden; D055815:Young Adult