title: Persisting hepatitis E virus infection leading to liver cirrhosis despite recovery of the immune system in an HIV-infected patient.
abstract: Chronic hepatitis E has been described several times in strongly immunosuppressed HIV-patients. We describe the persistence of HEV-infection in an HIV-patient despite a restored immune response. This case demonstrates that HEV-infection can persist in formerly immunosuppressed individuals irrespective of the current immune status. Persisting HEV-infection can lead to chronic inflammation and liver cirrhosis. Physicians should be aware of the possibility of chronic hepatitis E even in patients that are not any longer immunocompromised. However, ribavirin is an efficient treatment option.
authors.affiliation: Center for Infectiology (CIB), Seestr. 13, 13353 Berlin, Germany. Electronic address: ingiliz@zibp.de.
authors.forename: P
authors.initials: P
authors.lastname: Ingiliz
authors.affiliation: Ärzteforum Seestrasse, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Mayr
authors.affiliation: MIB Medical Laboratory, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Obermeier
authors.affiliation: Vivantes Klinikum Neukölln, Institute for Pathology, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Herbst
authors.affiliation: Department of Virology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Polywka
authors.affiliation: Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Pischke
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000097:blood; D015658:HIV Infections / Q000150:complications*; D016751:Hepatitis E / Q000188:drug therapy*; D016752:Hepatitis E virus / Q000235:genetics; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D012254:Ribavirin