title: A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients.
abstract: BACKGROUND
  Sesame oil and rice bran oil are known for their unsaturated fatty acids and antioxidants contents and have been reported to reduce the cardiovascular risk.
  
  
  OBJECTIVE
  To determine the effect of a blend of 20% unrefined cold-pressed lignans-rich sesame oil and 80% physically refined γ-oryzanol-rich rice bran oil (Vivo) as cooking oil in mild-to-moderate hypertensive patients.
  
  
  METHODS
  In this prospective, open-label dietary approach, 300 hypertensive patients and 100 normotensives were divided into groups as: (1) normotensives treated with sesame oil blend, (2) hypertensives treated with sesame oil blend, (3) hypertensives treated with nifedipine, a calcium channel blocker (20 mg/d), and (4) hypertensives receiving the combination of sesame oil blend and nifedipine (20 mg/d). Sesame oil blend was supplied to respective groups, and they were instructed to use it as the only cooking oil for 60 days. Resting blood pressure was measured at days 0, 15, 30, 45, and 60, whereas the fasting lipid profile was measured at days 0 and 60.
  
  
  RESULTS
  Significant reduction in blood pressure (systolic, diastolic, and mean arterial) from days 0 to 15, 30, 45, and 60 were observed in hypertensives treated with sesame oil blend alone (P < .001), nifedipine alone (P < .001), and combination of sesame oil blend and nifedipine (P < .001). Sesame oil blend with nifedipine-treated group showed greatest reduction in blood pressure. Total cholesterol, low-density lipoprotein cholesterol, triglycerides, and non-high-density lipoprotein cholesterol levels reduced, whereas high-density lipoprotein cholesterol levels increased significantly only in hypertensives treated with sesame oil blend alone and the combination of sesame oil blend and nifedipine (P < .001).
  
  
  CONCLUSIONS
  We demonstrate for the first time that using a blend of sesame oil and rice bran oil as cooking oil showed a significant antihypertensive and lipid-lowering action and had noteworthy additive effect with antihypertensive medication.
authors.affiliation: Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka, Japan. Electronic address: devsankara@gmail.com.
authors.forename: Sankar
authors.initials: S
authors.lastname: Devarajan
authors.affiliation: Department of Non-communicable Diseases, Indian Council of Medical Research, New Delhi, India.
authors.forename: Ravinder
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Research and Development, Adani Wilmar Limited, Ahmedabad, India.
authors.forename: Biprabuddha
authors.initials: B
authors.lastname: Chatterjee
authors.affiliation: Department of Biochemistry, School of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman.
authors.forename: Amanat
authors.initials: A
authors.lastname: Ali
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D016022:Case-Control Studies; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D000073879:Rice Bran Oil; D012715:Sesame Oil / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D008055:Lipids; D010938:Plant Oils; D012715:Sesame Oil; D000073879:Rice Bran Oil
keywords: Blend of sesame oil and rice bran oil; Blood pressure; Hypertensives; Lipid profile; Normotensives