title: Replicates and repeats.
abstract: The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mouse compared with the control. The results are reported as statistically significant, with impressive 'n' values in each condition: the authors say that n = 7 in each case. They confidently conclude that the level of each of the three proteins is increased in the knockout mutant.
authors.affiliation: BMC Biology, BioMed Central, 236 Gray's Inn Road, London, WC1X 8HB, UK. BMCBiologyEditorial@biomedcentral.com.
authors.forename: Graham
authors.initials: G
authors.lastname: Bell
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D055786:Gene Knockout Techniques; D051379:Mice; D018345:Mice, Knockout; D015203:Reproducibility of Results