title: Photocurable bioactive bone cement based on hydroxyethyl methacrylate-poly(acrylic/maleic) acid resin and mesoporous sol gel-derived bioactive glass.
abstract: This paper reports on strong and bioactive bone cement based on ternary bioactive SiO2-CaO-P2O5 glass particles and a photocurable resin comprising hydroxyethyl methacrylate (HEMA) and poly(acrylic/maleic) acid. The as-cured composite represented a compressive strength of about 95 MPa but it weakened during soaking in simulated body fluid, SBF, qua its compressive strength reached to about 20 MPa after immersing for 30 days. Biodegradability of the composite was confirmed by reducing its initial weight (~32%) as well as decreasing the molecular weight of early cured resin during the soaking procedure. The composite exhibited in vitro calcium phosphate precipitation in the form of nanosized carbonated hydroxyapatite, which indicates its bone bonding ability. Proliferation of calvarium-derived newborn rat osteoblasts seeded on top of the composite was observed during incubation at 37 °C, meanwhile, an adequate cell supporting ability was found. Consequently, it seems that the produced composite is an appropriate alternative for bone defect injuries, because of its good cell responses, high compressive strength and ongoing biodegradability, though more in vivo experiments are essential to confirm this assumption.
authors.affiliation: Biomaterials group, Nanotechnology and Advanced Materials Department, Materials & Energy Research Center, P.O. BOX 31787-316, Alborz, 31787/316, Iran. Electronic address: S-hesaraki@merc.ac.ir.
authors.forename: S
authors.initials: S
authors.lastname: Hesaraki
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001843:Bone Cements / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry*; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D014466:Ultraviolet Rays; D014961:X-Ray Diffraction
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D001843:Bone Cements; D005782:Gels; D008689:Methacrylates; C416205:calcium oxide-silicon dioxide-diphosphorus pentoxide glass; C005044:hydroxyethyl methacrylate; D017886:Durapatite
keywords: Bioactive glass; Biomaterials; Composite; Light-cure; Mesoporous material; Nanoapatite