title: OncDRS: An integrative clinical and genomic data platform for enabling translational research and precision medicine.
abstract: We live in the genomic era of medicine, where a patient's genomic/molecular data is becoming increasingly important for disease diagnosis, identification of targeted therapy, and risk assessment for adverse reactions. However, decoding the genomic test results and integrating it with clinical data for retrospective studies and cohort identification for prospective clinical trials is still a challenging task. In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS) and a suite of tools called Oncology Data Retrieval Systems (OncDRS). OncDRS enables seamless data integration, secure and self-navigated query and extraction of clinical and genomic data from heterogeneous sources. Within a year of release, the system has facilitated more than 1500 research queries and has delivered data for more than 50 research studies.
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: John
authors.initials: J
authors.lastname: Orechia
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Ameet
authors.initials: A
authors.lastname: Pathak
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Yunling
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Aniket
authors.initials: A
authors.lastname: Nawani
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Andrey
authors.initials: A
authors.lastname: Belozerov
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Fontes
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Camille
authors.initials: C
authors.lastname: Lakhiani
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Chetan
authors.initials: C
authors.lastname: Jawale
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Chetansharan
authors.initials: C
authors.lastname: Patel
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Quinn
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Botvinnik
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Eddie
authors.initials: E
authors.lastname: Mei
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Cotter
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: James
authors.initials: J
authors.lastname: Byleckie
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Mollie
authors.initials: M
authors.lastname: Ullman-Cullere
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Padam
authors.initials: P
authors.lastname: Chhetri
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Poornima
authors.initials: P
authors.lastname: Chalasani
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Purushotham
authors.initials: P
authors.lastname: Karnam
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Ronald
authors.initials: R
authors.lastname: Beaudoin
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sahu
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Yelena
authors.initials: Y
authors.lastname: Belozerova
authors.affiliation: Dana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
authors.forename: Jomol P
authors.initials: JP
authors.lastname: Mathew
keywords: Clinical & genomic data integration; Clinical and translational informatics; Genomic profile; Next generation sequencing data; Precision medicine