title: Intracystic papillary carcinoma of the breast: A SEER database analysis of implications for therapy.
abstract: BACKGROUND
  Intracystic papillary carcinoma (IPC) of the breast is a rare breast malignancy with an indolent course. However, patients can develop metastatic disease. Indications for surgery and radiotherapeutic management have not been well elucidated.
  
  
  METHODS
  We identified 2649 female patients with IPC from the Surveillance, Epidemiology, and End Results (SEER) registry. Differences in demographics, clinical features and survival of patients were assessed using the Kaplan-Meier method and Cox regression.
  
  
  RESULTS
  Median age was 67 years. The majority of patients were white with Stage 0 disease. Most patients had lymph node evaluation and only 34% received radiation therapy. Using a log-rank test, survival was significantly better in Caucasian compared to African-American patients, patients with early stage disease, negative lymph nodes and those who received radiation (all p < 0.0001). In a Cox regression survival model adjusting for age, stage and grade, patients who were African-American (hazard ratio [HR] 2.0, CI 1.4-2.8; p < 0.0001) had a significantly higher risk of death than Caucasians. Patients who received radiation therapy (HR 0.5, CI 0.3-0.7; p = 0.0003) had a lower chance of death than patients that did not undergo radiation.
  
  
  CONCLUSIONS
  Overall, IPC has a good prognosis. Survival is improved in Caucasian patients and in patients who receive radiation therapy. Radiation therapy should be offered to women with IPC who undergo breast conserving surgery.
authors.affiliation: Wake Forest School of Medicine, Department of Surgery, Section of Surgical Oncology, USA.
authors.forename: Harveshp
authors.initials: H
authors.lastname: Mogal
authors.affiliation: Wake Forest School of Medicine, Department of Radiation Oncology, USA.
authors.forename: Doris R
authors.initials: DR
authors.lastname: Brown
authors.affiliation: Wake Forest School of Medicine, Department of Biostatistics, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Isom
authors.affiliation: Wake Forest School of Medicine, Department of Surgery, Section of Surgical Oncology, USA.
authors.forename: Kayla
authors.initials: K
authors.lastname: Griffith
authors.affiliation: Wake Forest School of Medicine, Department of Surgery, Section of Surgical Oncology, USA. Electronic address: mmcnatt@wakehealth.edu.
authors.forename: Marissa
authors.initials: M
authors.lastname: Howard-McNatt
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D002291:Carcinoma, Papillary / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D016016:Proportional Hazards Models; D011878:Radiotherapy / Q000401:mortality; D018426:SEER Program; D044465:White People / Q000706:statistics & numerical data
keywords: Breast cancer; Intracystic papillary carcinoma; SEER