title: Single-layer MoS2 nanosheet grafted upconversion nanoparticles for near-infrared fluorescence imaging-guided deep tissue cancer phototherapy.
abstract: A multifunctional nanostructure is prepared by covalently grafting upconversion nanoparticles (UCNPs) with chitosan functionalized MoS2 (MoS2-CS) and folic acid (FA) and then loading phthalocyanine (ZnPc) on the surface of MoS2, which integrates photodynamic therapy (PDT) with photothermal therapy (PTT) and upconversion luminescence imaging into one system for enhanced antitumor efficiency.
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore. rxu@ntu.edu.sg.
authors.forename: Jianyu
authors.initials: J
authors.lastname: Han
authors.affiliation: Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Duke-NUS Medical School, Singapore. cmrhkm@nccs.com.sg.
authors.forename: Hongping
authors.initials: H
authors.lastname: Xia
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore. rxu@ntu.edu.sg.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Duke-NUS Medical School, Singapore. cmrhkm@nccs.com.sg.
authors.forename: Shik Nie
authors.initials: SN
authors.lastname: Kong
authors.affiliation: Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Duke-NUS Medical School, Singapore. cmrhkm@nccs.com.sg.
authors.forename: Amudha
authors.initials: A
authors.lastname: Deivasigamani
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore. rxu@ntu.edu.sg.
authors.forename: Rong
authors.initials: R
authors.lastname: Xu
authors.affiliation: Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Duke-NUS Medical School, Singapore. cmrhkm@nccs.com.sg.
authors.forename: Kam M
authors.initials: KM
authors.lastname: Hui
authors.affiliation: Faculty of Materials and Energy, Institute for Clean Energy and Advanced Materials, Southwest University, 2 Tiansheng Road, Beibei, Chongqing, 400715, China. yjkang@swu.edu.cn.
authors.forename: Yuejun
authors.initials: Y
authors.lastname: Kang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy; D045744:Cell Line, Tumor; D004220:Disulfides / Q000737:chemistry; D005260:Female; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D008982:Molybdenum / Q000737:chemistry; D036103:Nanotechnology; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D061848:Optical Imaging / Q000379:methods; D010789:Phototherapy / Q000379:methods*; D023041:Xenograft Model Antitumor Assays
chemical_list: D004220:Disulfides; D008982:Molybdenum; C082964:molybdenum disulfide