title: Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications.
abstract: Advances in next-generation sequencing and mass spectrometry have revealed widespread messenger RNA modifications and RNA editing, with dramatic effects on mammalian transcriptomes. Factors introducing, deleting, or interpreting specific modifications have been identified, and analogous with epigenetic terminology, have been designated "writers," "erasers," and "readers." Such modifications in the transcriptome are referred to as epitranscriptomic changes and represent a fascinating new layer of gene expression regulation that has only recently been appreciated. Here, we outline how RNA editing and RNA modification can rapidly affect gene expression, making both processes as well suited to respond to cellular stress and to regulate the transcriptome during development or circadian periods.
authors.affiliation: Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, A-1090 Vienna, Austria.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Licht
authors.affiliation: Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, A-1090 Vienna, Austria Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A-1030 Vienna, Austria michael.jantsch@meduniwien.ac.at.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Jantsch
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D012313:RNA / Q000235:genetics*; D017393:RNA Editing / Q000235:genetics*; D059467:Transcriptome / Q000235:genetics*
chemical_list: D012313:RNA