title: Acid-mediated topological control in a functionalized foldamer.
abstract: Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. sam.thompson@chem.ox.ac.uk.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Knipe
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. sam.thompson@chem.ox.ac.uk.
authors.forename: Sam
authors.initials: S
authors.lastname: Thompson
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. sam.thompson@chem.ox.ac.uk and Department of Chemistry, New York University, New York, New York 10003, USA. andrew.hamilton@nyu.edu.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D048289:Imidazolidines / Q000138:chemical synthesis / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry; D008968:Molecular Conformation; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: D048289:Imidazolidines; D008698:Mesylates; D011108:Polymers; D011725:Pyridines; D014269:Trifluoroacetic Acid; C012077:trifluoromethanesulfonic acid