title: Sinigrin and Its Therapeutic Benefits.
abstract: Sinigrin (allyl-glucosinolate or 2-propenyl-glucosinolate) is a natural aliphatic glucosinolate present in plants of the Brassicaceae family, such as broccoli and brussels sprouts, and the seeds of Brassica nigra (mustard seeds) which contain high amounts of sinigrin. Since ancient times, mustard has been used by mankind for its culinary, as well as medicinal, properties. It has been systematically described and evaluated in the classical Ayurvedic texts. Studies conducted on the pharmacological activities of sinigrin have revealed anti-cancer, antibacterial, antifungal, antioxidant, anti-inflammatory, wound healing properties and biofumigation. This current review will bring concise information about the known therapeutic activities of sinigrin. However, the information on known biological activities is very limited and, hence, further studies still need to be conducted and its molecular mechanisms also need to be explored. This review on the therapeutic benefits of sinigrin can summarize current knowledge about this unique phytocompounds.
authors.affiliation: Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. anishamajumdar@gmail.com.
authors.forename: Anisha
authors.initials: A
authors.lastname: Mazumder
authors.affiliation: Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. anupma.feb1@gmail.com.
authors.forename: Anupma
authors.initials: A
authors.lastname: Dwivedi
authors.affiliation: Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Jeanetta.DuPlessis@nwu.ac.za.
authors.forename: Jeanetta
authors.initials: J
authors.lastname: du Plessis
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D001937:Brassica / Q000737:chemistry; D005961:Glucosinolates / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D012639:Seeds / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005961:Glucosinolates; C010330:sinigrin
keywords: Brassicaceae family; anticancer; glucosinolates; mustard; myrosinase; sinigrin