title: NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders.
abstract: Dietary exclusion of gluten-containing products has become increasingly popular in the general population, and currently ∼30% of people in the United States are limiting gluten ingestion. Although celiac disease (CD), wheat allergy (WA), and nonceliac gluten sensitivity (NCGS) constitute a spectrum of gluten-related disorders that require exclusion of gluten from the diet, together these account for a relatively small percentage of those following a gluten-free diet, and the vast majority has no medical necessity for doing so. Differentiating between CD, WA, and NCGS has important prognostic and therapeutic implications. Because of the protean manifestations of gluten-related disorders, it is not possible to differentiate between them on clinical grounds alone. This clinical report will compare and contrast the manifestations of gluten-related disorders, emphasize the importance of differentiating between these conditions, discuss initial and subsequent tests needed to confirm the diagnosis, and provide recommendations on treatment and follow-up for each condition.
authors.affiliation: *The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus†Center for Celiac Research, Massachusetts General Hospital for Children and Celiac Program, Harvard Medical School, Boston‡Section of Pediatric Gastroenterology, Hepatology and Nutrition, Celiac Disease Center, University of Chicago, IL§Center for Celiac Disease, Digestive Health Institute, Children's Hospital Colorado, University of Colorado Denver School of Medicine, Aurora||New York University School of Medicine, Special Projects Division of Pediatric Gastroenterology, NYU Langone Medical Center¶Division of Pediatric Gastroenterology and Celiac Disease Center, Columbia University Medical Center, New York, NY#Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia.
authors.forename: Ivor D
authors.initials: ID
authors.lastname: Hill
authors.forename: Alessio
authors.initials: A
authors.lastname: Fasano
authors.forename: Stefano
authors.initials: S
authors.lastname: Guandalini
authors.forename: Edward
authors.initials: E
authors.lastname: Hoffenberg
authors.forename: Joseph
authors.initials: J
authors.lastname: Levy
authors.forename: Norelle
authors.initials: N
authors.lastname: Reilly
authors.forename: Ritu
authors.initials: R
authors.lastname: Verma
mesh_terms: D002446:Celiac Disease / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D002648:Child; D002662:Child Health Services; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D008297:Male