title: Analysis of Cytokine Levers in Pleural Effusions of Tuberculous Pleurisy and Tuberculous Empyema.
abstract: The aim is to examine whether the interleukin-1β (IL-1β), IL-2, IL-6, tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor type-1 (PAI-1), and tissue plasminogen activator (t-PA) levels were different in pleural effusions of tuberculous pleurisy and tuberculous empyema. IL-1β, IL-2, IL-6, TNF-α, PAI-1, and t-PA levels in pleural fluids of 40 patients with tuberculous pleurisy and 38 patients with tuberculous empyema were measured. The levels of IL-1β, PAI-1, and t-PA in the pleural effusions were different between tuberculous pleurisy and tuberculous empyema; it could be helpful to differentiate the two diseases. The levels of PAI-1, IL-1β were higher and t-PA, IL-6 were lower in pleural effusions of the patients with tuberculous empyema and who must undergo operation than the patients who could be treated with closed drainage and anti-TB chemotheraphy. These indications may be helpful to evaluate whether the patient needs the operation.
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Lei
authors.identifier: 0000-0001-8515-8509
authors.initials: L
authors.lastname: Yang
authors.affiliation: Tuberculosis Immunology Department, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Hu
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Fu-Gen
authors.initials: FG
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Xiu-Jun
authors.initials: XJ
authors.lastname: Chang
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Tian-Hui
authors.initials: TH
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
authors.forename: Zi-Tong
authors.identifier: 0000-0002-7252-6381
authors.initials: ZT
authors.lastname: Wang
mesh_terms: D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D004654:Empyema, Tuberculous / Q000378:metabolism*; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D010996:Pleural Effusion / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014396:Tuberculosis, Pleural / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D055815:Young Adult
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D007376:Interleukin-2; D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; D014409:Tumor Necrosis Factor-alpha; D010959:Tissue Plasminogen Activator