title: Staphylococcal Scalded Skin Syndrome in an Adult on Chemotherapy.
abstract: Staphylococcal scalded skin syndrome is a toxin-mediated, epidermolytic condition that uncommonly affects adults. A 51-year-old man receiving chemotherapy for leukemia presented with a large geographic erosion with superficial sloughing and multiple smaller lesions elsewhere. Biopsy revealed complete subcorneal splitting with multiple detached fragments of normal-appearing stratum corneum with fragments of attached acantholytic granular keratinocytes. Mild epidermal dysmaturation was also noted. Based on these findings, the patient was started on oral cephalexin, topical mupirocin, and topical clobetasol. His lesions improved significantly over the course of 1 week.
authors.affiliation: Program in Dermatopathology, Department of Pathology, Boston, Mass., USA.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Harvard Combined Dermatology Residency Program, Harvard Medical School, Boston, Mass., USA.
authors.forename: Hillary C
authors.initials: HC
authors.lastname: Tsibris
authors.affiliation: Department of Dermatology, Brigham and Women's Hospital, Boston, Mass., USA.
authors.forename: Arash
authors.initials: A
authors.lastname: Mostaghimi
authors.affiliation: Program in Dermatopathology, Department of Pathology, Boston, Mass., USA.
authors.forename: Christine G
authors.initials: CG
authors.lastname: Lian
keywords: Adult; Chemotherapy; Staphylococcal scalded skin syndrome