title: Clinicopathologic features associated with recurrence of the odontogenic keratocyst: a cohort retrospective analysis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the influence of clinical, radiographic, surgical and histopathologic parameters in the recurrence of disease in a series of odontogenic keratocysts (OKCs).
  
  
  METHODS
  The sample comprised 24 sporadic OKC lesions from 24 patients. All patients had no previous treatment history and were treated by the same surgeon using a uniform treatment protocol (enucleation with peripheral ostectomy preceded or not preceded by decompression).
  
  
  RESULTS
  Fourteen lesions (58.4%) were first submitted to decompression procedure. Eight patients (33%) developed recurrent lesions, with a mean follow-up time of 60.5 months (standard deviation [SD] = 31.3) and a mean disease-free interval for recurrent lesions of 19 months (SD = 4.9). Recurrence was significantly associated with poor clinical response to decompression (P = .027), remaining tooth with radiographic evidence of insinuation of the lesion between the dental roots (P = .009), and the presence of budding of the basal cells layer together with epithelial islands in the fibrous capsule (P = .019).
  
  
  CONCLUSIONS
  Clinical, radiographic and histopathologic parameters may affect the relapse rate of OKCs and should individually guide treatment choice.
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil.
authors.forename: Joanna Farias
authors.initials: JF
authors.lastname: Cunha
authors.affiliation: Department of Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil.
authors.forename: Carolina Cavalieri
authors.initials: CC
authors.lastname: Gomes
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil.
authors.forename: Ricardo Alves
authors.initials: RA
authors.lastname: de Mesquita
authors.affiliation: Department of Pediatrics, School of Medicine, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil.
authors.forename: Eugênio Marcos
authors.initials: EM
authors.lastname: Andrade Goulart
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil.
authors.forename: Wagner Henriques
authors.initials: WH
authors.lastname: de Castro
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil. Electronic address: Rsgomez@ufmg.br.
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002648:Child; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome