title: Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level.
abstract: Fritillaria is one of the most important herbs in Chinese traditional medicine and represents an annual ￥700 million industry. It is often used as an anti-inflammatory, pain relieving and antitussive medicine. However, the mechanisms of these effects are still unclear. Peimine is one of active ingredients of Fritillaria. Using the patch-clamp technique, we profiled the action of Peimine against selected ion channels stably expressed in HEK 293 cell lines. Our data indicated that Peimine was not only able to block the Nav1.7 ion channel but also preferably inhibited the Kv1.3 ion channel. Thus, the study suggested potential mechanisms of Fritillaria as a pain relieving and anti-inflammatory herb.
authors.affiliation: Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Xu
authors.affiliation: Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China.
authors.forename: Lanying
authors.initials: L
authors.lastname: Pan
authors.affiliation: Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China.
authors.forename: Ailian
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Safety Pharmacology Division, Olivepharmasolutions Ltd, 333 Changhong Road, Wukang 313200, PR China.
authors.forename: Qingmao
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Safety Pharmacology Division, Olivepharmasolutions Ltd, 333 Changhong Road, Wukang 313200, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.affiliation: Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China.
authors.forename: Haiyin
authors.initials: H
authors.lastname: Lu
authors.affiliation: Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China. Electronic address: ychen@zafu.edu.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002595:Cevanes / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D031410:Fritillaria / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D062556:NAV1.7 Voltage-Gated Sodium Channel / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D010946:Plants, Medicinal / Q000737:chemistry; D061567:Voltage-Gated Sodium Channel Blockers / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D002595:Cevanes; D004365:Drugs, Chinese Herbal; D062556:NAV1.7 Voltage-Gated Sodium Channel; C486866:SCN9A protein, human; D061567:Voltage-Gated Sodium Channel Blockers; C014242:verticine
keywords: Fritillaria; Inflammation; Kv1.3; Nav1.7; Pain; Peimine