title: The Role of MicroRNAS in Ankylosing Spondylitis.
abstract: Ankylosing spondylitis (AS) is a common and genetically heterozygous inflammatory rheumatic disease characterized by new bone formation, ankylosis and inflammation of hip, sacroiliac joints and spine. Until now, there is no method for early diagnosis of AS and the effective treatment available for AS patients remain largely undefined.We searched articles indexed in PubMed (MEDLINE) database using Medical Subject Heading (MeSH) or Title/Abstract words ("microRNA" and "ankylosing spondylitis") from inception up to November 2015.Genetic polymorphisms of miRNAs and their targets might alter the risk of AS development whereas certain miRNAs exhibit correlation with inflammatory index.Let-7i and miR-124 were upregulated whereas miR-130a was downregulated in circulating immune cells of AS patients. These deregulated miRNAs could modulate key immune cell functions, such as cytokine response and T-cell survival.miRNA deregulation is key to AS pathogenesis. However, clinical utilization of miRNAs for management of AS patients requires further support from future translational studies.
authors.affiliation: From the Department of Orthopedics Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (ZL, JS); State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences and Department of Medicine & Therapeutics (SHW, WKKW); and Department of Anaesthesia and Intensive Care (MTVC), The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Sunny H
authors.initials: SH
authors.lastname: Wong
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Shen
authors.forename: Matthew T V
authors.initials: MTV
authors.lastname: Chan
authors.forename: William Ka Kei
authors.initials: WKK
authors.lastname: Wu
mesh_terms: D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D013167:Spondylitis, Ankylosing / Q000235:genetics*
chemical_list: D035683:MicroRNAs