title: Adipocytokines and bone metabolism markers in relation to bone mineral values in early pubertal boys with different physical activity.
abstract: BACKGROUND
  We aimed to examine the associations of adipocytokines and circulating bone metabolism markers with bone mineral parameters in early pubertal boys with different physical activity level.
  
  
  METHODS
  Eighty-six early pubertal boys were divided into active and non-active boys according to the accumulated moderate-to-vigorous physical activity (MVPA) level. Body composition and bone mineral parameters were assessed and testosterone, leptin, adiponectin, osteocalcin (OC), and C-terminal telopeptide of type I collagen (CTX) were measured.
  
  
  RESULTS
  Active subjects had significantly lower (p<0.05) body mass, body mass index (BMI), fat mass (FM), leptin, and sedentary time values, while non-active subjects had lower (p<0.05) vigorous physical activity level and femoral neck bone mineral density (FN-BMD). OC contributed to the models in physically active group and explained 6.6% and 9.7% of variance in whole body (WB) [F(5,44)=10.847; p<0.001] and lumbar spine bone mineral content (LS-BMC) [F(5,44)=4.158; p=0.004], respectively. No other biochemical parameters were found to be related to bone mineral parameters in either the active or non-active group.
  
  
  CONCLUSIONS
  Bone metabolism markers were positively correlated with bone mineral values only in active pubertal boys. Leptin and adiponectin were not related to bone mineral parameters in active and non-active pubertal boys.
authors.forename: Donvina
authors.initials: D
authors.lastname: Vaitkeviciute
authors.forename: Evelin
authors.initials: E
authors.lastname: Lätt
authors.forename: Jarek
authors.initials: J
authors.lastname: Mäestu
authors.forename: Toivo
authors.initials: T
authors.lastname: Jürimäe
authors.forename: Meeli
authors.initials: M
authors.lastname: Saar
authors.forename: Priit
authors.initials: P
authors.lastname: Purge
authors.forename: Katre
authors.initials: K
authors.lastname: Maasalu
authors.forename: Jaak
authors.initials: J
authors.lastname: Jürimäe
mesh_terms: D054392:Adipokines / Q000097:blood*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D024042:Collagen Type I / Q000097:blood; D015444:Exercise; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D011629:Puberty, Precocious / Q000378:metabolism*
chemical_list: D054392:Adipokines; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin