title: Diastereoselective Cascade Assembly of Functionalized Pyrano[3,4-c]pyrrole Derivatives.
abstract: A novel convenient approach for the synthesis of densely functionalized pyrano[3,4-c]pyrrole derivatives was developed. Cascade transformation of the simple adducts of tetracyanoethylene (TCNE) and ketones (4-oxoalkane-1,1,2,2-tetracarbonitriles) in the presence of aldehyde under the action of acetic acid led to the diastereoselective formation of targeted pyrano[3,4-c]pyrroles. The reaction pathway was thoroughly investigated, and proposed intermediates were shown to be consistent with experiment.
authors.affiliation: Ulyanov Chuvash State University , Moskovsky pr., 15, Cheboksary 428015, Russia.
authors.forename: Mikhail Yu
authors.initials: MY
authors.lastname: Ievlev
authors.affiliation: Ulyanov Chuvash State University , Moskovsky pr., 15, Cheboksary 428015, Russia.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Ershov
authors.affiliation: Lomonosov Moscow State University , Leninskie gory, 1, Moscow 119991, Russia.
authors.forename: Viktor A
authors.initials: VA
authors.lastname: Tafeenko