title: Head and neck chondrosarcomas: Analysis of the Surveillance, Epidemiology, and End Results database.
abstract: Chondrosarcoma is a rare tumor of the head and neck. Because of the limited clinical data, no studies have conducted a thorough comparison between head and neck chondrosarcomas and those arising at other body sites.
  
  
  
  Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared 682 patients with chondrosarcomas of the head and neck with 4757 patients with non-head and neck chondrosarcomas, evaluating disease-specific survival (DSS) and overall survival (OS) based on tumor location, histology, grade, stage, and treatment.
  
  
  
  Head and neck chondrosarcomas displayed a lower grade (p < .001) and stage (p < .0001) compared with other chondrosarcomas. Overall, chondrosarcomas of the head and neck had significantly higher DSS and OS than non-head and neck chondrosarcomas (p < .001).
  
  
  
  Chondrosarcomas of the head and neck display a lower grade and stage compared with other chondrosarcomas. DSS and OS were significantly greater for chondrosarcomas of the head and neck. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1359-1366, 2016.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ellis
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Gerry
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia.
authors.forename: J Kenneth
authors.initials: JK
authors.lastname: Byrd
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002813:Chondrosarcoma / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D018570:Risk Assessment; D018426:SEER Program; D012737:Sex Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
keywords: Epidemiology; Surveillance; and End Results (SEER); chondrosarcoma; head and neck; survival; treatment