title: Expression of miRNA-26b in the diagnosis and prognosis of patients with non-small-cell lung cancer.
abstract: OBJECTIVE
  To investigate the correlation between miR-26b and non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  NSCLC tissues and normal lung tissues that were more than 7 cm adjacent from tumor were collected from 154 NSCLC patients. Additionally, 63 normal specimens from benign lung disease were selected as the control group. Real-time fluorescent quantitative PCR was used to detect miR-26b expression in tissues.
  
  
  RESULTS
  miR-26b expression in NSCLC tissues was significantly lower than in other two types of tissues. Receiver operating characteristic curve analysis showed that the area under the curve was 0.856 with sensitivity and specificity of 79.9 and 79.4%, respectively. miR-26b expression was a risk factor for poor prognosis of NSCLC.
  
  
  CONCLUSIONS
  The expression of miR-26b is downregulated in NSCLC tissues, and it might be useful in the diagnosis and prognosis of NSCLC patients.
authors.affiliation: Department of Radiation Oncology, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, PR China.
authors.forename: Li-Peng
authors.initials: LP
authors.lastname: Jiang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, PR China.
authors.forename: Zhi-Tu
authors.initials: ZT
authors.lastname: Zhu
authors.affiliation: Department of Prosthodontics, Second Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, PR China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: He
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: diagnosis; miR-26b; miRNAs; non-small-cell lung cancer; prognosis