title: [Large-cell lung carcinoma by the 2015 WHO classification: a clinicopathologic analysis of 93 cases].
abstract: OBJECTIVE
  To analyze the clinicopathologic characteristics of large-cell lung carcinoma (LCC) subtypes according to the 2015 WHO classification.
  
  
  METHODS
  A total of 93 cases of LCC were identified among 1 634 cases of morphologically undifferentiated non-small cell lung carcinoma. Clinicopathologic and immunohistochemical characteristics were retrospectively reviewed.
  
  
  RESULTS
  Among 93 cases of LCC, 50 cases were solid adenocarcinoma (53.8%), 21 cases were non-keratinzing squamous cell carcinoma (22.6%), 3 cases were adenosquamous carcinoma (3.2%), 8 cases were large cell carcinoma with unclear immunohistochemical features (8.6%), and 11 cases were large cell carcinoma with null immunohistochemical features (11.8%). No significant differences in clinical features were found among various immunophenotypes. The overall survival of 1, 3 and 5 years of all cases was 51.0%, 5.4% and 1.1%, respectively and the mean survival was (15.2±1.2)months. Notably the null type had the lowest survival rate of 18% in one year, significantly worse than those of solid adenocarcinoma and non-keratinzing squamous cell carcinoma.
  
  
  CONCLUSIONS
  The 2015 WHO classification based on immunohistochemical phenotype replaces the morphological approach in separating poorly differentiated non-small cell lung carcinoma from the former large cell lung carcinoma. The null immunohistochemical subtype may represent a distinct subtype of undifferentiated carcinoma with the worst prognosis.
authors.affiliation: Department of Pathology, Nanjing Clinical Academy of Southern Medical University, Nanjing Jinling Hospital, Nanjing 210002, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Zhang
authors.forename: X Y
authors.initials: XY
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Shen
authors.forename: Y F
authors.initials: YF
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology; D018196:Carcinoma, Adenosquamous / Q000401:mortality / Q000473:pathology; D018287:Carcinoma, Large Cell / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000145:classification / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D008175:Lung Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate; D014944:World Health Organization