title: Targeted Therapy of HER2-Negative Breast Cancer.
abstract: Personalized and targeted treatments are the most discussed topics in oncology. However, how much personalized medicine is standard of care nowadays and how much is part of our hope for a better future? So far, only a few targeted therapies are available in daily practice for the treatment of human epidermal growth factor receptor 2 (HER2)-negative breast cancer. And even for these few targeted agents - besides those targeting the estrogen receptor (ER) for endocrine treatment - thus far, predictive factors are missing. There are many new drugs and strategies under evaluation but, unfortunately, they are being developed without any cross-comparison. What drug will we choose for which patient in the future? Without answering this question oncologists will not be able to individualize treatment. Predictive factors for every new splendid drug are eagerly needed before it comes to an approval.
authors.affiliation: University Hospital Heidelberg, Breast Unit, National Center for Tumor Diseases, Heidelberg, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Schütz
authors.forename: Christoph
authors.initials: C
authors.lastname: Domschke
authors.forename: Andreas
authors.initials: A
authors.lastname: Schneeweiss
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D018719:Erb-b2 Receptor Tyrosine Kinases