title: Combined treatment of UVA irradiation and antibiotics induces greater bactericidal effects on Vibrio parahaemolyticus.
abstract: The presence of antibiotics in the environment and their subsequent impact on the development of multi-antibiotic resistant bacteria has raised concerns globally. Consequently, much research is focused on a method to produce a better disinfectant. We have established a disinfectant system using UVA-LED that inactivates pathogenic bacteria. We assessed the bactericidal efficiency of a combination of UVA-LED and antibiotics against Vibrio parahaemolyticus. Combined use of antibiotic drugs and UVA irradiation was more bactericidal than UVA irradiation or antibacterial drugs alone. The bactericidal synergy was observed at low concentrations of each drug that are normally unable to kill the bacteria. This combination has the potential to become a sterilization technology.
authors.affiliation: Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Hou
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Nakahashi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mawatari
authors.forename: Takaaki
authors.initials: T
authors.lastname: Shimohata
authors.forename: Takashi
authors.initials: T
authors.lastname: Uebanso
authors.forename: Yumi
authors.initials: Y
authors.lastname: Harada
authors.forename: Akari
authors.initials: A
authors.lastname: Tsunedomi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Emoto
authors.forename: Masatake
authors.initials: M
authors.lastname: Akutagawa
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Kinouchi
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D004203:Disinfection / Q000379:methods*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D009643:Norfloxacin / Q000494:pharmacology; D014466:Ultraviolet Rays; D014736:Vibrio parahaemolyticus / Q000187:drug effects* / Q000472:pathogenicity / Q000528:radiation effects*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002701:Chloramphenicol; D000667:Ampicillin; D009643:Norfloxacin