title: [PERSPECTIVES OF DEVELOPMENT OF LIVE RECOMBINANT ANTHRAX VACCINES BASED ON OPPORTUNISTIC AND APATHOGENIC MICROORGANISMS].
abstract: Live genetic engineering anthrax vaccines on the platform of avirulent and probiotic micro-organisms are a safe and adequate alternative to preparations based on attenuated Bacillus anthracis strains. Mucosal application results in a direct contact of the vaccine preparations with mucous membranes in those organs arid tissues of the macro-organisms, that are exposed to the pathogen in the first place, resulting in a development of local and systemic immune response. Live recombinant anthrax vaccines could be used both separately as well as in a prime-boost immunization scheme. The review focuses on immunogenic and protective properties of experimental live genetic engineering prearations, created based on members of geni of Salmonella, Lactobacillus and adenoviruses.
authors.forename: P Yu
authors.initials: PY
authors.lastname: Popova
authors.forename: N I
authors.initials: NI
authors.lastname: Mikshis
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000276:immunology; D000818:Animals; D000881:Anthrax / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D022122:Anthrax Vaccines / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D001408:Bacillus anthracis / Q000187:drug effects / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D005818:Genetic Engineering / Q000379:methods*; D005822:Genetic Vectors / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D007778:Lactobacillus / Q000235:genetics / Q000276:immunology; D051379:Mice; D019936:Probiotics / Q000378:metabolism / Q000494:pharmacology; D012475:Salmonella / Q000235:genetics / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic
chemical_list: D022122:Anthrax Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic