title: Hypertonic saline monotherapy in children with perennial allergic rhinitis: a pilot study.
abstract: Perennial allergic rhinitis (PAR) is very common in children and has a relevant impact on their families. House dust mites (HDM) are the most relevant cause of PAR. The present pilot study aimed to evaluate whether hypertonic saline (3%) nasal spray as monotherapy is able to improve: nasal symptom severity and parental perception of rhinitis control, sleep, and school performance in HDM-mono-sensitized children with PAR. Globally, 25 children (13 males and 12 females; mean age 9.5±3.1 years) were treated for 3 weeks. They were visited at baseline, at the end of treatment, and after a 2-week follow-up. Hypertonic saline significantly reduced total symptom score, and improved the perception, according to their parents, of rhinitis control, sleep, and school performance. In conclusion, the present pilot study provided the first evidence that 3% hypertonic saline monotherapy was able to relieve nasal symptoms and parental perception of PAR impact as well as being safe and well tolerated.
authors.affiliation: Department of Pediatrics, A.O. Fatebenefratelli, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Barberi
authors.affiliation: Department of Pediatrics, A.O. San Paolo, University of Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: D'Auria
authors.affiliation: Department of Pediatrics, A.O. Fatebenefratelli, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bernardo
authors.affiliation: Department of Pediatrics, A.O. Fatebenefratelli, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.affiliation: Department of Pediatrics, A.O. San Paolo, University of Milan, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Pietra
authors.affiliation: Department of Pediatrics, A.O. Fatebenefratelli, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pinto
authors.affiliation: IRCCS-AOU San Martino, Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ferrero
authors.affiliation: IRCCS-AOU San Martino, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ciprandi
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D006982:Hypertonic Solutions / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D012965:Sodium Chloride / Q000627:therapeutic use*
chemical_list: D006982:Hypertonic Solutions; D012965:Sodium Chloride