title: Complete dataset for 2-treatment, 2-sequence, 2-period efavirenz bioequivalence study conducted with nightly dosing.
abstract: The efavirenz pharmacokinetic raw data presented in this article was obtained in an average bioequivalence study between a local brand and Stocrin (Merck Sharp & Dohme, purchased from Australia, batch H009175, expiration date November 2013). Dose was administered at night (9:00 p.m.) two hours after food intake. Fourteen healthy subjects, 8 women and 6 men, completed the study. For each subject, 15 data points until 96 h post-administration are included. Subject demographic characteristics and sequences of administration are provided along with individual pharmacokinetic profiles of efavirenz obtained for both formulations after a single oral dose of 600 mg. This data provides information in support of the research article "Sex-by-formulation interaction assessed through a bioequivalence study of efavirenz tablets" [1].
authors.affiliation: Bioavailability and Bioequivalence Centre for Medicine Evaluation (CEBIOBE) - Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ibarra
authors.affiliation: Bioavailability and Bioequivalence Centre for Medicine Evaluation (CEBIOBE) - Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay.
authors.forename: Laura
authors.initials: L
authors.lastname: Magallanes
authors.affiliation: Bioavailability and Bioequivalence Centre for Medicine Evaluation (CEBIOBE) - Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay.
authors.forename: Marianela
authors.initials: M
authors.lastname: Lorier
authors.affiliation: Bioavailability and Bioequivalence Centre for Medicine Evaluation (CEBIOBE) - Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay.
authors.forename: Marta
authors.initials: M
authors.lastname: Vázquez
authors.affiliation: Bioavailability and Bioequivalence Centre for Medicine Evaluation (CEBIOBE) - Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay.
authors.forename: Pietro
authors.initials: P
authors.lastname: Fagiolino
keywords: Bioequivalence; Efavirenz