title: The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention.
abstract: Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in this regard still remains unanswered. This review summarizes the recent information on NO and its role in carcinogenesis and tumor progression, as well as dietary chemopreventive agents which have NO-modulating properties with safe cytotoxic profile. Understanding the molecular mechanisms and cross-talk modulating NO effect by these chemopreventive agents can allow us to develop better therapeutic strategies for cancer treatment.
authors.affiliation: School of Life Sciences, Manipal University, Zayed University, Dubai, United Arab Emirates.
authors.forename: Huzefa
authors.initials: H
authors.lastname: Vahora
authors.affiliation: Department of Natural Science and Public Health, College of Sustainability Sciences and Humanities, Zayed University, Dubai, United Arab Emirates.
authors.forename: Munawwar Ali
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Department of Natural Science and Public Health, College of Sustainability Sciences and Humanities, Zayed University, Dubai, United Arab Emirates.
authors.forename: Usama
authors.initials: U
authors.lastname: Alalami
authors.affiliation: School of Life Sciences, Manipal University, Zayed University, Dubai, United Arab Emirates.
authors.forename: Arif
authors.initials: A
authors.lastname: Hussain
keywords: Chemoprevention; Endothelial nitric oxide synthase; Inducible nitric oxide synthase; Neoplasms; Nitric oxide