title: Effects of omentectomy in addition to sleeve gastrectomy on the metabolic and inflammatory profiles of obese rats.
abstract: BACKGROUND
  Visceral obesity has been considered a risk factor for metabolic and cardiovascular complications. In an attempt to reduce the visceral adipose tissue, omentectomy has been proposed to be performed along with bariatric surgery.
  
  
  OBJECTIVE
  The goal of this study was to evaluate whether omentectomy associated with sleeve gastrectomy (SG) is beneficial to the inflammatory and metabolic profile of rats fed a standard diet (STD) or high-fat diet (HFD).
  
  
  METHODS
  University hospital, Brazil.
  
  
  METHODS
  For this experiment, male Wistar rats were randomly divided into 6 groups as follows: sham surgery (STD+L or HFD+L), SG alone (STD+SG or HFD+SG), or SG with omentectomy (STD+SGO or HFD+SGO). Anthropometric data and metabolic profiles were evaluated, and the tissue expression of inflammatory markers in the visceral adipose tissue was measured.
  
  
  RESULTS
  In rats with diet-induced obesity treated with SG with or without omentectomy, there was a reduction in weight (HFD+SG: P<.01 and HFD+SGO: P<.05), adiposity (HFD+SG: P<.001 and HFD+SGO: P<.05), plasma levels of glucose (HFD+SG: P<.01 and HFD+SGO: P<.01), plasma levels of C-peptide (HFD+SG: P<.01 and HFD+SGO: P<.001), plasma levels of insulin (HFD+SG: P<.05 and HFD+SGO: P<.001), plasma levels of total cholesterol (HFD+SG: P<.01 and HFD+SGO: P<.01), and tissue expression of TNF-α (HFD+SG: P<.001 and HFD+SGO: P<.01), but there was no statistically significant difference between the groups in which omentectomy was performed or was not.
  
  
  CONCLUSIONS
  In this study, we did not observe additional beneficial effects due to omentectomy associated with SG in the metabolic profile and tissue expression of inflammatory markers.
authors.affiliation: Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil; Department of Surgery, Fundação Hospitalar de Montes Claros / Hospital Aroldo Tourinho, Montes Claros, Minas Gerais, Brazil.
authors.forename: Thaísa
authors.initials: T
authors.lastname: Soares Crespo
authors.affiliation: Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
authors.forename: João Marcus
authors.initials: JM
authors.lastname: Oliveira Andrade
authors.affiliation: Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil; Department of Medicine, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
authors.forename: Antônio Sérgio
authors.initials: AS
authors.lastname: Barcala Jorge
authors.affiliation: Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
authors.forename: Alfredo Maurício
authors.initials: AM
authors.lastname: Batista de Paula
authors.affiliation: Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
authors.forename: André Luiz
authors.initials: AL
authors.lastname: Sena Guimarães
authors.affiliation: Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil; Institute of Agricultural Sciences. Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil. Electronic address: sergiosousas@hotmail.com.
authors.forename: Sérgio Henrique
authors.initials: SH
authors.lastname: Sousa Santos
mesh_terms: D000818:Animals; D050110:Bariatric Surgery / Q000379:methods*; D015415:Biomarkers / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D059305:Diet, High-Fat; D005743:Gastrectomy / Q000379:methods*; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology; D008297:Male; D009767:Obesity, Morbid / Q000601:surgery*; D009852:Omentum / Q000601:surgery*; D011897:Random Allocation; D017208:Rats, Wistar; D015431:Weight Loss / Q000502:physiology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D002784:Cholesterol
keywords: Inflammation markers; Obesity; Omentectomy; Sleeve gastrectomy; Weight loss; bariatric surgery