title: A prospective cohort study assessing the reactogenicity of pertussis and influenza vaccines administered during pregnancy.
abstract: BACKGROUND
  Pertussis vaccination during pregnancy can prevent 91% of infant infections. In 2015, antenatal pertussis vaccination programs were introduced across Australia.
  
  
  METHODS
  To monitor the safety of this program, pregnant women who received trivalent influenza vaccine (TIV) and/or diphtheria-tetanus-acellular pertussis vaccine (dTpa) were surveyed by text message seven days post-vaccination about possible adverse events following immunization (AEFI). Univariate logistic regression models were used to calculate the odds of reporting an AEFI following dTpa compared to TIV. Similar analyses were used to compare AEFI reported by women who received a previous dose of dTpa in 2011/2012 as part of a state-wide cocooning program.
  
  
  RESULTS
  Of 5155 women, 4347 (84.3%) replied; 10.8% indicated they experienced an AEFI. There was no difference in the proportion of women who reported any reaction by vaccine; however, women who received dTpa were more likely to report a local reaction than women who received TIV (7.1% and 3.2%, respectively; OR: 2.29; 95% CI: 1.61-3.26). There was evidence suggesting local reactions were more common among women with a previous dose of dTpa (11.4%) compared to women with no previous dose (6.0%; OR: 2.00; 95% CI: 0.95-4.25); 11 (0.3%) women reported attending a hospital emergency department. Subsequent follow-up indicated symptoms resolved and mother and infant were healthy. There was no difference in the proportion of women attending hospital by vaccine (p > 0.05).
  
  
  CONCLUSIONS
  Data on systemic and local reactions following receipt of TIV and dTpa during pregnancy support the safety of antenatal vaccination.
authors.affiliation: Communicable Disease Control Directorate, Western Australia Department of Health, Shenton Park, Western Australia 6008, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6008, Australia. Electronic address: Annette.Regan@health.wa.gov.au.
authors.forename: Annette K
authors.initials: AK
authors.lastname: Regan
authors.affiliation: Communicable Disease Control Directorate, Western Australia Department of Health, Shenton Park, Western Australia 6008, Australia.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Tracey
authors.affiliation: Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, Subiaco, Western Australia 6008, Australia; School of Paediatrics and Child Health, University of Western Australia, Crawley, Western Australia 6008, Australia; Princess Margaret Hospital for Children, Subiaco, Western Australia 6008, Australia.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Blyth
authors.affiliation: Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, Subiaco, Western Australia 6008, Australia; School of Paediatrics and Child Health, University of Western Australia, Crawley, Western Australia 6008, Australia; Princess Margaret Hospital for Children, Subiaco, Western Australia 6008, Australia.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Richmond
authors.affiliation: Communicable Disease Control Directorate, Western Australia Department of Health, Shenton Park, Western Australia 6008, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6008, Australia.
authors.forename: Paul V
authors.initials: PV
authors.lastname: Effler
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D001315:Australia; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology; D005260:Female; D006801:Humans; D017589:Immunization Programs; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011446:Prospective Studies; D060145:Text Messaging
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D007252:Influenza Vaccines
keywords: Adverse events; Pertussis vaccine; Pregnancy; Safety; Seasonal influenza vaccine