title: Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents.
abstract: Cancer is a leading cause of death worldwide. Several classes of drugs are available to treat different types of cancer. Currently, researchers are paying significant attention to the development of drugs at the nanoscale level to increase their target specificity and to reduce their concentrations. Nanotechnology is a promising and growing field with multiple subdisciplines, such as nanostructures, nanomaterials, and nanoparticles. These materials have gained prominence in science due to their size, shape, and potential efficacy. Nanomedicine is an important field involving the use of various types of nanoparticles to treat cancer and cancerous cells. Synthesis of nanoparticles targeting biological pathways has become tremendously prominent due to the higher efficacy and fewer side effects of nanodrugs compared to other commercial cancer drugs. In this review, different medicinal plants and their active compounds, as well as green-synthesized metallic nanoparticles from medicinal plants, are discussed in relation to their anticancer activities.
authors.affiliation: Biotechnology Program, Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Campus Jeli, 17600 Jeli, Malaysia.
authors.forename: Pasupuleti Visweswara
authors.initials: PV
authors.lastname: Rao
authors.affiliation: Biotechnology Program, Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Campus Jeli, 17600 Jeli, Malaysia.
authors.forename: Devi
authors.initials: D
authors.lastname: Nallappan
authors.affiliation: Department of Biochemistry, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh 517502, India.
authors.forename: Kondeti
authors.initials: K
authors.lastname: Madhavi
authors.affiliation: Department of Parasitology, Graduate School of Health Sciences, Kobe University, Kobe 654-0142, Japan.
authors.forename: Shafiqur
authors.initials: S
authors.lastname: Rahman
authors.affiliation: Department of Fundamental and Applied Sciences, Universiti Teknologi Petronas, 32610 Tronoh, Malaysia.
authors.forename: Lim
authors.initials: L
authors.lastname: Jun Wei
authors.affiliation: Human Genome Centre, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.
authors.forename: Siew Hua
authors.initials: SH
authors.lastname: Gan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D055772:Green Chemistry Technology; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D050997:Nanomedicine; D009369:Neoplasms / Q000188:drug therapy*; D064209:Phytochemicals / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D064209:Phytochemicals