title: Everolimus-induced near-resolution of giant cardiac rhabdomyomas and large renal angiomyolipoma in a newborn with tuberous sclerosis complex.
abstract: We report a case of a newborn, affected by tuberous sclerosis complex, with a prenatally diagnosed giant cardiac rhabdomyoma associated with a large renal angiomyolipoma presenting as a duct-depending lesion not treatable by surgery. After receiving everolimus, a mammalian target of rapamycin inhibitor, we observed a rapid, significant, and durable reduction of both lesions without remarkable side effects.
authors.affiliation: Department of Paediatric and Congenital Cardiac Surgery and Cardiology,Ospedali Riuniti,Ancona,Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Colaneri
authors.affiliation: Department of Paediatric and Congenital Cardiac Surgery and Cardiology,Ospedali Riuniti,Ancona,Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Quarti
authors.affiliation: Department of Paediatric and Congenital Cardiac Surgery and Cardiology,Ospedali Riuniti,Ancona,Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Pozzi
mesh_terms: D018207:Angiomyolipoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004452:Echocardiography; D000068338:Everolimus / Q000008:administration & dosage*; D006338:Heart Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D012207:Rhabdomyoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications*
chemical_list: D000970:Antineoplastic Agents; D000068338:Everolimus
keywords: Cardiac rhabdomyoma; angiomyolipoma; everolimus; tuberous sclerosis complex