title: Calcium, Reactive Oxygen Species, and Synaptic Plasticity.
abstract: In this review article, we address how activity-dependent Ca(2+)signaling is crucial for hippocampal synaptic/structural plasticity and discuss how changes in neuronal oxidative state affect Ca(2+)signaling and synaptic plasticity. We also analyze current evidence indicating that oxidative stress and abnormal Ca(2+)signaling contribute to age-related synaptic plasticity deterioration.
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago, Chile; and Center of Molecular Studies of the Cell and Physiology and Biophysics Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile chidalgo@med.uchile.cl.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Hidalgo
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago, Chile; and.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Arias-Cavieres
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D002118:Calcium