title: ATtRACT-a database of RNA-binding proteins and associated motifs.
abstract: RNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA transport, splicing, polyadenylation and stability. Understanding the interaction between RBPs and RNA is key to improve our knowledge of RNA processing, localization and regulation in a global manner. Despite advances in recent years, a unified non-redundant resource that includes information on experimentally validated motifs, RBPs and integrated tools to exploit this information is lacking. Here, we developed a database named ATtRACT (available athttp://attract.cnic.es) that compiles information on 370 RBPs and 1583 RBP consensus binding motifs, 192 of which are not present in any other database. To populate ATtRACT we (i) extracted and hand-curated experimentally validated data from CISBP-RNA, SpliceAid-F, RBPDB databases, (ii) integrated and updated the unavailable ASD database and (iii) extracted information from Protein-RNA complexes present in Protein Data Bank database through computational analyses. ATtRACT provides also efficient algorithms to search a specific motif and scan one or more RNA sequences at a time. It also allows discoveringde novomotifs enriched in a set of related sequences and compare them with the motifs included in the database.Database URL:http:// attract. cnic. es.
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, Madrid 28029, Spain.
authors.forename: Girolamo
authors.initials: G
authors.lastname: Giudice
authors.forename: Fátima
authors.initials: F
authors.lastname: Sánchez-Cabo
authors.affiliation: Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernández Almagro 3, Madrid 28029, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Torroja
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, Madrid 28029, Spain National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK elara@cnic.es carlos.torroja@cnic.es.
authors.forename: Enrique
authors.initials: E
authors.lastname: Lara-Pezzi
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology; D003628:Database Management Systems; D030562:Databases, Protein; D066264:Datasets as Topic; D006801:Humans; D020407:Internet; D016601:RNA-Binding Proteins; D014584:User-Computer Interface
chemical_list: D016601:RNA-Binding Proteins