title: Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma.
abstract: Purpose. To determine if the frequency of the genotype of MMP-2 (-1306 C/T) Rs243865 has an influence on the development of pituitary adenoma (PA). Methods. The study enrolled n = 84 patients with PA and a random sample of the population n = 318 (reference group). The genotyping test of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method. Results. Analysis of MMP-2 (-1306 C/T) gene polymorphism has not revealed any differences in the genotype (C/C, C/T, and T/T) distribution between the PA patients and the reference group (as follows: 50%, 44%, and 6% versus 59.75%, 33.96%, and 6.29%). MMP-2 (-1306) C/C genotype was rarely observed in noninvasive PA compared to healthy controls: 35.1% versus 59.75%; p = 0.0049, as well C/C genotype being more frequently detected in nonrecurrence PA compared to healthy controls: 46.5% versus 59.75%; p = 0.0468. MMP-2 (-1306) C/T genotype was more frequently present in PA females compared to healthy controls females: 49.1% versus 33.66%; p = 0.041. Conclusion. Patients with noninvasive and nonrecurrence pituitary adenoma were the carriers of the C/C genotype significantly more frequently than their control counterparts and the C/T genotype in females was more frequent.
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
authors.forename: Brigita
authors.identifier: 0000-0002-1259-4999
authors.initials: B
authors.lastname: Glebauskiene
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania; Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
authors.forename: Rasa
authors.initials: R
authors.lastname: Liutkeviciene
authors.affiliation: Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
authors.forename: Alvita
authors.initials: A
authors.lastname: Vilkeviciute
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania; Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
authors.forename: Loresa
authors.initials: L
authors.lastname: Kriauciuniene
authors.affiliation: Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania; Medical Academy, Department of Neurosurgery, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
authors.forename: Giedrimantas
authors.initials: G
authors.lastname: Bernotas
authors.affiliation: Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania; Medical Academy, Department of Neurosurgery, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
authors.forename: Arimantas
authors.initials: A
authors.lastname: Tamasauskas
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
authors.forename: Dalia
authors.initials: D
authors.lastname: Zaliuniene