title: Ectopic intracranial germinoma.
abstract: Intracranial ectopic germinomas are often associated with synchronous midline disease. Germinomas involving the corpus callosum are exceedingly rare. The reported imaging appearance is not as varied as one might expect and a review of the literature reveals a few common imaging features amongst most ectopic lesions, including cyst formation. We report a 24-year-old man with panhypopituitarism. Neuroimaging revealed three enhancing lesions involving the pituitary infundibulum, the pineal region, and a parenchymal lesion involving the genu of the corpus callosum. The described ectopic mass, a parenchymal lesion, was associated with small peripheral cysts. Stereotactic biopsy and histopathological evaluation revealed this mass to be a germinoma. Following chemotherapy and radiation therapy, there was near-total resolution of the intracranial disease. Preoperative imaging plays an important role, not only in delineating the extent of disease, but also in assisting in generating an appropriate differential diagnosis. Germinomas in the corpus callosum are exceedingly rare but should be considered in the differential of any young patient with a characteristic cystic and solid intra-axial mass.
authors.affiliation: Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar Street, New Haven, CT 06520-8042, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Shankar
authors.affiliation: Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar Street, New Haven, CT 06520-8042, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar Street, New Haven, CT 06520-8042, USA.
authors.forename: Vivek B
authors.initials: VB
authors.lastname: Kalra
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Anita J
authors.initials: AJ
authors.lastname: Huttner
authors.affiliation: Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar Street, New Haven, CT 06520-8042, USA. Electronic address: ajay.malhotra@yale.edu.
authors.forename: Ajay
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology; D018237:Germinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D010870:Pineal Gland / Q000000981:diagnostic imaging / Q000473:pathology; D055815:Young Adult
keywords: Corpus callosum; Ectopic germinomas; Suprasellar