title: Rat cardiovascular telemetry: Marginal distribution applied to positive control drugs.
abstract: Cardiovascular effects are considered frequent during drug safety testing. This investigation aimed to characterize the pharmacological response of the conscious telemetered rat in vivo model to known cardiovascular active agents. These effects were analyzed using statistical analysis and cloud representation with marginal distribution curves for the contractility index and heart rate as to assess the effect relationship between cardiac variables. Arterial blood pressure, left ventricular pressure, electrocardiogram and body temperature were monitored. The application of data cloud with marginal distribution curves to heart rate and contractility index provided an interesting tactic during the interpretation of drug-induced changes particularly during selective time resolution (i.e. marginal distribution curves restricted to Tmax). Taken together, the present data suggests that marginal distribution curves can be a valuable interpretation strategy when using the rat cardiovascular telemetry model to detect drug-induced cardiovascular effects. Marginal distribution curves could also be considered during the interpretation of other inter-dependent parameters in safety pharmacology studies.
authors.affiliation: CiToxLAB North America, 445 Armand Frappier, Laval, QC H7V 4B3, Canada.
authors.forename: M V
authors.initials: MV
authors.lastname: Accardi
authors.affiliation: Faculty of Veterinary Medicine, University of Montreal, P.O. box 5000, St-Hyacinthe, QC J2S 7C6, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Troncy
authors.affiliation: CiToxLAB North America, 445 Armand Frappier, Laval, QC H7V 4B3, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Abtout
authors.affiliation: CiToxLAB North America, 445 Armand Frappier, Laval, QC H7V 4B3, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Ascah
authors.affiliation: CiToxLAB North America, 445 Armand Frappier, Laval, QC H7V 4B3, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Maghezzi
authors.affiliation: CiToxLAB North America, 445 Armand Frappier, Laval, QC H7V 4B3, Canada; Faculty of Veterinary Medicine, University of Montreal, P.O. box 5000, St-Hyacinthe, QC J2S 7C6, Canada. Electronic address: authiers@ca.citoxlab.com.
authors.forename: S
authors.initials: S
authors.lastname: Authier
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D003627:Data Interpretation, Statistical; D004562:Electrocardiography / Q000187:drug effects; D004567:Electrodes, Implanted; D006339:Heart Rate / Q000187:drug effects; D008133:Long QT Syndrome / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012449:Safety; D013686:Telemetry / Q000379:methods*; D016277:Ventricular Function, Left / Q000187:drug effects
keywords: Cloud analysis; Contractility; ECG; Left ventricular; PR; QT; Rat; Telemetry