title: Cyclodextrins as Protective Agents of Protein Aggregation: An Overview.
abstract: Cyclodextrins are extensively used in different fields (e.g., catalysis, chromatography, pharma, supramolecular chemistry, bioorganic chemistry, and bioinorganic chemistry), and their applications have been widely reviewed. Their main application in the field of pharmaceutical is as a drug carrier. This review overviews, for the first time, the use of cyclodextrins and their derivatives as antiaggregant agents in a number of proteins (e.g., amyloid-β, insulin, recombinant human growth hormone, prion protein, transthyretin, and α-synuclein) and some multimeric enzymes. There are many diseases that are correlated to protein misfolding and amyloid formation processes affecting numerous organs and tissues. There are over 30 different amyloid proteins and a number of corresponding diseases. Alzheimer's disease is the most common neurodegenerative disease. Treatment of these diseases is still a goal to reach, and many molecules are studied in this perspective. Cyclodextrins have also been studied, and they show great potential; as such, further studies could be very promising. This review aims to be a stimulus for the design of new cyclodextrin derivatives to obtain multifunctional systems with antiaggregant activity.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy.|Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B, Unità di Ricerca di Catania, 95125, Catania, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Oliveri
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy. gr.vecchio@unict.it.
authors.forename: Graziella
authors.identifier: http://orcid.org/0000-0001-8305-081X
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism; D019382:Human Growth Hormone / Q000235:genetics / Q000378:metabolism; D006801:Humans; D000072002:Prion Proteins / Q000737:chemistry / Q000378:metabolism; D020011:Protective Agents / Q000627:therapeutic use; D066263:Protein Aggregation, Pathological; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D003505:Cyclodextrins; D000072002:Prion Proteins; D020011:Protective Agents; D011506:Proteins; D019382:Human Growth Hormone
keywords: amyloid beta-peptides; cyclodextrins; drug delivery; insulin; sugars