title: Effect of Cellular Therapy in Progression of Becker's Muscular Dystrophy: A Case Study.
abstract: Becker muscular dystrophy (BMD) is an inherited disorder due to deletions of the dystrophin gene that leads to muscle weakness. Effects of bone marrow mononuclear cell (BMMNC) transplantation in Muscular Dystrophy have shown to be safe and beneficial. We treated a 20-year-old male suffering from BMD with autologous BMMNC transplantation followed by multidisciplinary rehabilitation. He presented with muscle weakness and had difficulty in performing his activities. The BMMNCs were transplanted via intrathecal and intramuscular routes. The effects were measured on clinical and functional changes. Over 9 months, gradual improvement was noticed in muscle strength, respiratory functions and North Star Ambulatory Assessment Scale. Functional Independence Measure, Berg Balance Score, Brooke and Vignos Scale remained stable indicating halting of the progression. The case report suggests that cellular therapy combined with rehabilitation may have possibility of repairing and regenerating muscle fibers and decreasing the rate of progression of BMD.
authors.affiliation: Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Research and Development, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Hemangi
authors.initials: H
authors.lastname: Sane
authors.affiliation: Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Nandini
authors.initials: N
authors.lastname: Gokulchandra
authors.affiliation: Department of Research and Development, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Rishabh
authors.initials: R
authors.lastname: Sharan
authors.affiliation: Department of Neuro-Rehabilitation, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Amruta
authors.initials: A
authors.lastname: Paranjape
authors.affiliation: Department of Research and Development, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Kulkarni
authors.affiliation: Department of Neuro-Rehabilitation, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Jayanti
authors.initials: J
authors.lastname: Yadav
authors.affiliation: Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute , Mumbai, India.
authors.forename: Prerna
authors.initials: P
authors.lastname: Badhe
keywords: Autologous Bone Marrow; Becker Muscular Dystrophy; Manual muscle strength; Mononuclear cells