title: Limbic Encephalitis Associated With GAD65 Antibodies: Brief Review of the Relevant literature.
abstract: Recently, many cases of autoimmune limbic encephalitis with positive GAD65 (glutamic acid decarboxylase) antibodies have been described in the scientific literature. However, it remains an understudied topic of great relevance to practicing neurologists. Thus, we report here a review of published cases, in English, of autoimmune limbic encephalitis with this type of antibodies, focusing on presenting symptoms and signs, associated conditions, and findings upon investigation. We also report treatment responses. We aim to offer a better description of the clinical spectrum of autoimmune limbic encephalitis associated with GAD65 antibodies as well as to expose its paraclinical features and outcome.
authors.affiliation: CHU de Québec - Neurological Science,Quebec,Canada.
authors.forename: Maude-Marie
authors.initials: MM
authors.lastname: Gagnon
authors.affiliation: CHU de Québec - Neurological Science,Quebec,Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Savard
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D003072:Cognition Disorders / Q000209:etiology; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D020363:Limbic Encephalitis / Q000150:complications / Q000276:immunology* / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D000906:Antibodies; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2
keywords: CNS inflammation; cognitive impairment; immune system; neuroimmunology; neuroinflammation; neurology – clinical; seizures; status epilepticus