title: Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes.
abstract: A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 μM up to 2 mM.
authors.affiliation: School of Medicine, Istanbul Kemerburgaz University, Istanbul, 34217, Turkey. cengizozalp@gmail.com.
authors.forename: V Cengiz
authors.initials: VC
authors.lastname: Özalp
authors.forename: Dilek
authors.initials: D
authors.lastname: Çam
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Hernandez
authors.forename: Luiza I
authors.initials: LI
authors.lastname: Hernandez
authors.forename: Thomas
authors.initials: T
authors.lastname: Schäfer
authors.forename: Hüseyin A
authors.initials: HA
authors.lastname: Öktem