title: The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.
abstract: Neuroblastoma is a childhood cancer derived from cells of neural crest origin. The hallmarks of its enigmatic character include its propensity for spontaneous regression under some circumstances and its association with paraneoplastic opsoclonus, myoclonus, and ataxia. The neurodevelopmental underpinnings of its origins may provide important clues for development of novel therapeutic and preventive agents for this frequently fatal malignancy and for the associated paraneoplastic syndromes. Ann Neurol 2016;80:13-23.
authors.affiliation: Department of Pediatrics, Cincinnati Children's Hospital and University of Cincinnati, Cincinnati, OH.
authors.forename: Nancy
authors.initials: N
authors.lastname: Ratner
authors.affiliation: Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Garrett M
authors.initials: GM
authors.lastname: Brodeur
authors.affiliation: Clinical School, the Children's Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Russell C
authors.initials: RC
authors.lastname: Dale
authors.affiliation: Department of Pediatrics, University of Rochester Medical Center, Rochester, NY.
authors.forename: Nina F
authors.initials: NF
authors.lastname: Schor
mesh_terms: D018450:Disease Progression; D006801:Humans; D058990:Molecular Targeted Therapy; D009365:Neoplasm Regression, Spontaneous; D009432:Neural Crest / Q000254:growth & development / Q000473:pathology*; D009447:Neuroblastoma / Q000150:complications / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D065886:Neurodevelopmental Disorders / Q000150:complications / Q000209:etiology* / Q000473:pathology; D053578:Opsoclonus-Myoclonus Syndrome / Q000276:immunology; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications / Q000209:etiology