title: Beyond canonical: The Wnt and β-catenin story.
abstract: This Editorial Guide uses Wnt-stimulated activation of the transcriptional activity of β-catenin, the canonical Wnt/β-catenin pathway, to illustrate the hazards of limiting research investigation and questions to those that fit the "canonical" view.
authors.affiliation: Board member, Science Signaling, AAAS, Washington, DC 20005, USA. Institute for Stem Cell and Regenerative Medicine, Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98109, USA.
authors.forename: Randall T
authors.initials: RT
authors.lastname: Moon
authors.affiliation: Editor, Science Signaling, AAAS, Washington, DC 20005, USA. ngough@aaas.org.
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
mesh_terms: D006801:Humans; D010506:Periodicals as Topic; D015533:Transcriptional Activation; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051176:beta Catenin