title: IgG4-related disease presenting with destructive sinonasal lesion mimicking malignancy.
abstract: IgG4-related disease is a newly recognized systemic fibroinflammatory disorder. We report a 36-year-old man who presented with intractable right nasal pain and frontal headache for 1 month. Computed tomography revealed an ill-defined lesion with bony erosion over the right anterior ethmoid sinus and middle turbinate. The lesion was resected through endoscopic anterior ethmoidectomy and middle turbinectomy. IgG4-related disease was definitively diagnosed according to histopathological features. Prednisolone was administered postoperatively. IgG4-related disease presenting with destructive sinonasal lesion mimicking malignancy is rare. Awareness is essential to avoid delayed diagnosis or unnecessary invasive intervention, because the disorder responds to glucocorticoid and immunosuppressant therapy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hsinchu MacKay Memorial Hospital, No.690, Sec. 2, Guangfu Rd, East Dist, Hsinchu City, 30071, Taiwan. chenbonien@yahoo.com.tw.|Mackay Junior College of Medicine, Nursing, and Management, New Taipei City, Taiwan. chenbonien@yahoo.com.tw.
authors.forename: Bo-Nien
authors.initials: BN
authors.lastname: Chen
mesh_terms: D000328:Adult; D001847:Bone Diseases / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004724:Endoscopy; D005004:Ethmoid Bone; D005938:Glucocorticoids / Q000627:therapeutic use; D051271:Headache Disorders, Secondary / Q000209:etiology; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis* / Q000188:drug therapy; D007074:Immunoglobulin G; D008297:Male; D009668:Nose Diseases / Q000209:etiology; D010146:Pain / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D012888:Skull Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D014420:Turbinates
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone
keywords: IgG4; IgG4-related disease; Pseudotumor; Sinonasal