title: [Effect of CD14 promoter variants on the susceptibility to laryngeal cancer].
abstract: OBJECTIVE
  To investigate the effects of -260C>T and -651C>T genetic variants in the promoter region of CD14 on the susceptibility to laryngeal cancer.
  
  
  METHODS
  A total of 163 patients with laryngeal cancer and 326 healthy subjects as controls were included. Genotypes of CD14 -260C>T (rs2569190) and -651C>T (rs5744455) variants were determined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Odd ratios (OR) and 95% confidence intervals (95%CI) were calculated with logistic regression analysis.
  
  
  RESULTS
  Compared with CD14 -651CC genotype carriers, -651TT genotype carriers had the increased risk of laryngeal cancer with the OR (95%CI) of 5.79 (2.38-14.11). When the -651TT genotype carriers were stratified by smoking status, the OR (95%CI) for laryngeal cancer was 8.64 (1.88-39.77) in nonsmokers and 4.74 (1.69-13.25) in smokers; the OR (95%CI) was 5.40 (1.10-26.45) in the light smokers and 4.30 (1.10-16.75) in the hevey smokers. When the -651TT genotype carriers were stratified by drinking status, the OR (95%CI) for laryngeal cancer was 6.48 (2.81-14.95) in nondrinkers and 2.01 (0.65-6.26) in drinkers. There was no significant difference in CD14 -260C>T genotype distribution between patients and controls.
  
  
  CONCLUSIONS
  Polymorphisms of -651C>T in CD14 promoter contribute to the susceptibility to laryngeal cancer in Chinese population.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Clinical Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Clinical Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Wen
authors.affiliation: Institute of Molecular Genetics, College of Life Science, North China University of Science and Technology, Tangshan 063000, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Lin
authors.affiliation: Institute of Molecular Genetics, College of Life Science, North China University of Science and Technology, Tangshan 063000, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D018950:Lipopolysaccharide Receptors