title: Prevalence of antineuronal antibodies in patients with encephalopathy of unknown etiology: Data from a nationwide registry in Korea.
abstract: We aimed to evaluate the prevalence of antineuronal antibodies in a nationwide cohort of patients with encephalopathy of unknown etiology. We screened 1699 patients with idiopathic encephalopathy who were referred from 70 hospitals across Korea for autoimmune synaptic and classic paraneoplastic antibodies. Those with cerebellar degeneration, sensory polyneuropathy or other paraneoplastic syndromes without encephalopathy were not included in this study. One-hundred and four patients (6.12%) had antibody-associated autoimmune encephalopathy. Autoimmune synaptic antibodies were identified in 89 patients (5.24%) and classic paraneoplastic antibodies were identified in 16 patients (0.94%). The patients with antibody-associated autoimmune encephalopathy comprised a small but significant portion of the total number of patients with encephalopathy of unknown cause.
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jung-Ick
authors.initials: JI
authors.lastname: Byun
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Soon-Tae
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Keun-Hwa
authors.initials: KH
authors.lastname: Jung
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jun-Sang
authors.initials: JS
authors.lastname: Sunwoo
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Departments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea.
authors.forename: Jangsup
authors.initials: J
authors.lastname: Moon
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Tae-Joon
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jung-Ah
authors.initials: JA
authors.lastname: Lim
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Soyun
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Do-Yong
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Department of Neurology, Asan Medical Center, Seoul, South Korea.
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Han
authors.affiliation: Department of Neurology, Samsung Medical Center, Seoul, South Korea.
authors.forename: Hyemin
authors.initials: H
authors.lastname: Jang
authors.affiliation: Department of Neurology, Ajou University Medical Center, Suwon, South Korea.
authors.forename: Hong Il
authors.initials: HI
authors.lastname: Suh
authors.affiliation: Department of Neurology, Catholic University of Korea Yeouido St. Mary's Hospital, Seoul, South Korea.
authors.forename: A-Hyun
authors.initials: AH
authors.lastname: Cho
authors.affiliation: Department of Neurology, Konkuk University, Seoul, South Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, South Korea.
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Shin
authors.affiliation: Department of Neurology, Korea University Anam Hospital, Seoul, South Korea.
authors.forename: Yong Seo
authors.initials: YS
authors.lastname: Koo
authors.affiliation: Kyungpook National University School of Medicine, Daegu, South Korea.
authors.forename: Woo Chan
authors.initials: WC
authors.lastname: Choi
authors.affiliation: Department of Neurology, Eulji General Hospital, Seoul, South Korea.
authors.forename: Woong-Woo
authors.initials: WW
authors.lastname: Lee
authors.affiliation: Department of Neurology, Soonchun Hyang University Hospital Cheonan, Cheonan, South Korea.
authors.forename: Nari
authors.initials: N
authors.lastname: Choi
authors.affiliation: Department of Neurology, Kangwon National University Hospital, Chuncheon, South Korea.
authors.forename: Seongheon
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
authors.forename: Hyunwoo
authors.initials: H
authors.lastname: Nam
authors.affiliation: Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
authors.forename: Dae Lim
authors.initials: DL
authors.lastname: Koo
authors.affiliation: Department of Psychiatry, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Minah
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
authors.forename: Byung Chan
authors.initials: BC
authors.lastname: Lim
authors.affiliation: Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
authors.forename: Jong-Hee
authors.initials: JH
authors.lastname: Chae
authors.affiliation: Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
authors.forename: Ki Joong
authors.initials: KJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Daejong
authors.initials: D
authors.lastname: Jeon
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Department of Neurology, Seoul National University Hospital Healthcare System Gangnam Center, South Korea.
authors.forename: Kyung-Il
authors.initials: KI
authors.lastname: Park
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Jung
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Protein Metabolism Research Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Manho
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: stemcell.snu@gmail.com.
authors.forename: Kon
authors.initials: K
authors.lastname: Chu
authors.affiliation: Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: sangkun2923@gmail.com.
authors.forename: Sang Kun
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000367:Age Factors; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid*; D001927:Brain Diseases / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009419:Nerve Tissue Proteins / Q000276:immunology*; D015995:Prevalence; D011506:Proteins / Q000276:immunology; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D047908:Intracellular Signaling Peptides and Proteins; C116499:LGI1 protein, human; D009419:Nerve Tissue Proteins; D011506:Proteins; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Autoimmune; Autoimmune synaptic antibody; Classic paraneoplastic antibody; Encephalopathy; Prevalence