title: One-pot synthesis and antifungal activity against plant pathogens of quinazolinone derivatives containing an amide moiety.
abstract: An efficient one-pot, three-component synthesis of quinazolinone derivatives containing 3-acrylamino motif was carried out using CeO2 nanoparticles as catalyst. Thirty-nine synthesized compounds were obtained with satisfied yield and elucidated by spectroscopic analysis. Four phytopathogenic fungi were chosen to test the antifungal activities by minimum inhibitory concentration (MIC) method. Compounds 4ag, 4bb, 4bc showed broad antifungal activities against at least three fungi, and dramatic effects of substituents on the activities were observed. Docking studies were established to explore the potential antifungal mechanism of quinazolinone derivatives as the chitinase inhibitors, and also verified the importance of the amide moiety.
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, PR China; Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Xi'an 710021, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, PR China; Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Xi'an 710021, PR China.
authors.forename: Yangmin
authors.initials: Y
authors.lastname: Ma
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, PR China.
authors.forename: Decheng
authors.initials: D
authors.lastname: Ren
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, PR China.
authors.forename: Pei
authors.initials: P
authors.lastname: Cheng
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, PR China.
authors.forename: Jiawen
authors.initials: J
authors.lastname: Zhao
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Institute of Theoretical and Simulational Chemistry, Academy of Fundamental and Interdisciplinary Science, Harbin Institute of Technology, Harbin 150080, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yao
mesh_terms: D000577:Amides / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000382:microbiology*; D052999:Quinazolinones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D000935:Antifungal Agents; D052999:Quinazolinones
keywords: 3-Acylamino substituted quinazolinones; CeO(2) nanoparticles; Molecular docking; Phytopathogenic fungi; Structure–activity relationship