title: A Three-Component Approach to 3,5-Diaryl-1,2,4-thiadiazoles under Transition-Metal-Free Conditions.
abstract: A novel route is disclosed for the synthesis of 1,2,4-thiadiazoles starting from amidines, elemental sulfur, and 2-methylquinolines or aldehydes under transition-metal-free conditions. This three-component approach affords efficient and rapid access to 3,5-diaryl substituted 1,2,4-thiadiazoles with good tolerance of a broad range of funcitional groups. Mechanistic studies reveal a radical-involved pathway.
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan 411105, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xie
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan 411105, China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Cai
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan 411105, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan 411105, China.
authors.forename: Huawen
authors.initials: H
authors.lastname: Huang
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan 411105, China.
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Deng