title: DNA Walker-Regulated Cancer Cell Growth Inhibition.
abstract: We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.
authors.affiliation: School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
authors.forename: Feiran
authors.initials: F
authors.lastname: Li
authors.affiliation: School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
authors.forename: Tae-Gon
authors.initials: TG
authors.lastname: Cha
authors.affiliation: School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Pan
authors.affiliation: School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
authors.forename: Altug
authors.initials: A
authors.lastname: Ozcelikkale
authors.affiliation: School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
authors.forename: Bumsoo
authors.initials: B
authors.lastname: Han
authors.affiliation: School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA. jchoi@purdue.edu.
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D052157:Aptamers, Nucleotide; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003094:Collagen / Q000737:chemistry; D021881:DNA, Catalytic / Q000737:chemistry*; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D061986:MCF-7 Cells; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000494:pharmacology*; D045663:Quantum Dots / Q000737:chemistry
chemical_list: C513936:AGRO 100; D000970:Antineoplastic Agents; D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D009838:Oligodeoxyribonucleotides; D003094:Collagen
keywords: DNA walker; DNAzyme; anticancer; growth inhibition; oligonucleotides