title: Implementation of a Ventilator-Associated Pneumonia Prevention Bundle in a Single PICU.
abstract: Ventilator-associated pneumonia is considered the second most frequent infection in pediatric intensive care, and there is agreement on its association with higher morbidity and increased healthcare costs. The goal of this study was to apply a bundle for ventilator-associated pneumonia prevention as a process for quality improvement in the PICU of Hospital Italiano de Buenos Aires, Argentina, aiming to decrease baseline ventilator-associated pneumonia rate by 25% every 6 months over a period of 2 years.
  
  
  
  Quasi-experimental uninterrupted time series.
  
  
  
  PICU of Hospital Italiano de Buenos Aires, Argentina.
  
  
  
  All mechanical ventilated patients admitted to the unit.
  
  
  
  It consisted of the implementation of an evidence-based ventilator-associated pneumonia prevention bundle adapted to our unit and using the plan-do-study-act cycle as a strategy for quality improvement. The bundle consisted of four main components: head of the bed raised more than 30°, oral hygiene with chlorhexidine, a clean and dry ventilator circuit, and daily interruption of sedation.
  
  
  
  Ventilator-associated pneumonia prevention team meetings started in March 2012, and the ventilator-associated pneumonia bundle was implemented in November 2012 after it had been developed and made operational. Baseline ventilator-associated pneumonia rate for the 2 years before intervention was 6.3 episodes every 1,000 mechanical ventilation days. ventilator-associated pneumonia rate evolution by semester and during the 2 years was, respectively, 5.7, 3.2, 1.8, and 0.0 episodes every 1,000 mechanical ventilation days. Monthly ventilator-associated pneumonia rate time series summarized in a 51-point control chart showed the presence of special cause variability after intervention was implemented.
  
  
  
  The implementation over 2 years of a ventilator-associated pneumonia prevention bundle specifically adapted to our unit using quality improvement tools was associated with a reduction in ventilator-associated pneumonia rate of 25% every 6 months and a nil rate in the last semester.
authors.affiliation: 1Pediatrics Department, Infection Control Committee, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. 2Pediatric Intensive Care Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. 3Respiratory Care Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. 4Nursing Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Analía
authors.initials: A
authors.lastname: De Cristofano
authors.forename: Verónica
authors.initials: V
authors.lastname: Peuchot
authors.forename: Andrea
authors.initials: A
authors.lastname: Canepari
authors.forename: Victoria
authors.initials: V
authors.lastname: Franco
authors.forename: Augusto
authors.initials: A
authors.lastname: Perez
authors.forename: Pablo
authors.initials: P
authors.lastname: Eulmesekian
mesh_terms: D000293:Adolescent; D001118:Argentina; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods / Q000592:standards*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric / Q000592:standards*; D008297:Male; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology / Q000517:prevention & control*; D058996:Quality Improvement / Q000706:statistics & numerical data; D012121:Respiration, Artificial / Q000379:methods / Q000592:standards*; D016896:Treatment Outcome