title: Comorbidity in acute pancreatitis relates to organ failure but not to local complications.
abstract: OBJECTIVE
  Organ failure and local complications contribute to morbidity and mortality in acute pancreatitis. Comorbidity is known to be related to organ failure. The impact of comorbidity on local complications has not yet been delineated. Moreover, it is not clear if the outcome of first-attacks and acute-on-chronic episodes, respectively, differs from outcome in all episodes.
  
  
  METHODS
  Consecutive cases of confirmed acute pancreatitis in a four-year period were reviewed. Charlson comorbidity index (CCI), complications (organ failure and local complications), disease severity (according to the revised Atlanta Classification), need for intensive care, and mortality were derived from the charts.
  
  
  RESULTS
  A total of 391 episodes of acute pancreatitis were included. Patients with organ failure were significantly older (P< 0.001) und had a higher CCI (P< 0.001) than patients without organ failure. Patients with and without local complications did not significantly differ in age or CCI. The complication rate of the entire cohort (n = 391; 47.1 %) was comparable with the complication rate of first-attacks (n = 269; 46.8 %) and acute-on-chronic episodes (n = 68; 47.1 %). The majority of the twelve deceased patients had been old and/or chronically ill. Six of these patients had an advanced malignant disease.
  
  
  CONCLUSIONS
  Comorbidity and age clearly are contributors to organ failure and mortality. Local complications occur independently of age and concomitant diseases. The overall complication rate is not significantly influenced by preceding inflammation of the pancreas. To further improve care in patients with acute pancreatitis special attention should be given to old and multi-morbid patients.
authors.forename: G
authors.initials: G
authors.lastname: Weitz
authors.forename: J
authors.initials: J
authors.lastname: Woitalla
authors.forename: P
authors.initials: P
authors.lastname: Wellhöner
authors.forename: K J
authors.initials: KJ
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Büning
authors.forename: K
authors.initials: K
authors.lastname: Fellermann
mesh_terms: D000208:Acute Disease; D017677:Age Distribution; D000368:Aged; D000437:Alcoholism / Q000401:mortality*; D015984:Causality; D002908:Chronic Disease / Q000401:mortality*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000401:mortality*; D009369:Neoplasms / Q000175:diagnosis / Q000401:mortality*; D010195:Pancreatitis / Q000175:diagnosis / Q000401:mortality*; D012307:Risk Factors; D017678:Sex Distribution; D015996:Survival Rate