title: Endoplasmic reticulum stress is activated in acute pancreatitis.
abstract: Endoplasmic reticulum (ER) is one of the most important cell organelles in the body, regulating protein synthesis, folding and aggregation. Endoplasmic reticulum stress (ERS) is a particular subcellular pathological process involving an imbalance of homeostasis and ER disorder. In the early stage of ERS, cells show a protective unfolded protein response that changes the cellular transcriptional and translational programs to alleviate the process. Therefore, a certain degree of ERS can activate the protective adaptation of cells, whereas sustained severe ERS triggers an apoptotic signal and leads to apoptosis. Acute pancreatitis is a disease caused by trypsin digestion of the pancreas, although the pathogenesis is not completely understood. However, a close association has been suggested between pancreatitis and ERS. This article reviewed relevant research advances and discussed the effect of ERS on the development and progression of acute pancreatitis.
authors.affiliation: Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Jian Sheng
authors.initials: JS
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Wei Min
authors.initials: WM
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Yi Na
authors.initials: YN
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Qin Fen
authors.initials: QF
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D004721:Endoplasmic Reticulum / Q000502:physiology*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D010179:Pancreas / Q000503:physiopathology*; D010195:Pancreatitis / Q000503:physiopathology*; D056811:Unfolded Protein Response / Q000502:physiology
keywords: endoplasmic reticulum stress; inflammation; pancreatitis