title: Research Approaches and Methods for Evaluating the Protein Quality of Human Foods Proposed by an FAO Expert Working Group in 2014.
abstract: The Protein Digestibility Corrected Amino Acid Score (PDCAAS) has been adopted for assessing protein quality in human foods since 1991, and the shortcomings of using the PDCAAS have been recognized since its adoption. The 2011 FAO Expert Consultation recognized that the Digestible Indispensable Amino Acid Score (DIAAS) was superior to the PDCAAS for determining protein quality. However, there were insufficient human data on amino acid digestibility before adopting the DIAAS. More human data were needed before DIAAS could be implemented. In 2014, FAO convened an expert working group to propose and agree on research protocols using both human-based assays and animal models to study ileal amino acid digestibility (metabolic availability) of human foods. The working group identified 5 research protocols for further research and development. A robust database of protein digestibility of foods commonly consumed worldwide, including those consumed in low-income countries, is needed for an informed decision on adopting the DIAAS. A review on the impacts of using the DIAAS on public health policies is necessary. It would be advantageous to have a global coordinating effort to advance research and data collection. Collaboration with international and national agriculture institutes is desirable. Opportunities should be provided for young researchers, particularly those from developing countries, to engage in protein-quality research for sustainable implementation of DIAAS. To conclude, the DIAAS is a conceptually preferable method compared with the PDCAAS for protein and amino acid quality evaluation. However, the complete value of the DIAAS and its impact on public health nutrition cannot be realized until there are sufficient accumulated ileal amino acid digestibility data on human foods that are consumed in different nutritional and environmental conditions, measured by competent authorities. A future meeting may be needed to evaluate the size and quality of the data set and to determine the timeline for full adoption and implementation of the DIAAS.
authors.affiliation: Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy; warren.lee@fao.org.
authors.forename: Warren Tk
authors.initials: WT
authors.lastname: Lee
authors.affiliation: Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy;
authors.forename: Robert
authors.initials: R
authors.lastname: Weisell
authors.affiliation: Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy;
authors.forename: Janice
authors.initials: J
authors.lastname: Albert
authors.affiliation: AgroParisTech, Paris, France;
authors.forename: Daniel
authors.initials: D
authors.lastname: Tomé
authors.affiliation: St. John's Research Institute, Bangalore, India; and.
authors.forename: Anura V
authors.initials: AV
authors.lastname: Kurpad
authors.affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Uauy
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001682:Biological Availability; D016208:Databases, Factual; D003906:Developing Countries; D004032:Diet / Q000592:standards*; D004044:Dietary Proteins / Q000378:metabolism / Q000592:standards*; D004063:Digestion; D006301:Health Services Needs and Demand; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D007391:International Cooperation; D012107:Research Design; D014480:United Nations
chemical_list: D000596:Amino Acids; D004044:Dietary Proteins
keywords: DIAAS; amino acids; digestibility; protein; protein quality; stable isotopes