title: The microenvironment controls invadosome plasticity.
abstract: Invadosomes are actin-based structures involved in extracellular matrix degradation. Invadosomes is a term that includes podosomes and invadopodia, which decorate normal and tumour cells, respectively. They are mainly organised into dots or rosettes, and podosomes and invadopodia are often compared and contrasted. Various internal or external stimuli have been shown to induce their formation and/or activity. In this Commentary, we address the impact of the microenvironment and the role of matrix receptors on the formation, and dynamic and degradative activities of invadosomes. In particular, we highlight recent findings regarding the role of type I collagen fibrils in inducing the formation of a new linear organisation of invadosomes. We will also discuss invadosome plasticity more generally and emphasise its physio-pathological relevance.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux F-33076, France Université de Bordeaux, Bordeaux F-33076, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Di Martino
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux F-33076, France Université de Bordeaux, Bordeaux F-33076, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Henriet
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux F-33076, France Université de Bordeaux, Bordeaux F-33076, France.
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Ezzoukhry
authors.affiliation: MN3T, Inserm U1109, Strasbourg 67200, France Université de Strasbourg, Strasbourg 67000, France LabEx Medalis, Université de Strasbourg, Strasbourg 67000, France Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg 67000, France.
authors.forename: Jacky G
authors.initials: JG
authors.lastname: Goetz
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux F-33076, France Université de Bordeaux, Bordeaux F-33076, France.
authors.forename: Violaine
authors.initials: V
authors.lastname: Moreau
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux F-33076, France Université de Bordeaux, Bordeaux F-33076, France frederic.saltel@inserm.fr.
authors.forename: Frederic
authors.initials: F
authors.lastname: Saltel
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D060833:Cellular Microenvironment / Q000502:physiology*; D024042:Collagen Type I / Q000378:metabolism; D055354:Exosomes / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans
chemical_list: D000199:Actins; D024042:Collagen Type I
keywords: Cell invasion; Collagen; Invadopodia; Invadosome; Matrix degradation; Podosome