title: [European Registry on the management of Helicobacter pylori infection (Hp-EuReg protocol): The first results of Russian centers].
abstract: OBJECTIVE
  To assess the clinical practice of diagnosis and treatment in patients with Helicobacter pylori infection and to compare this practice with the international guidelines in the European Registry on the management of Helicobacter pylori infection, Hp-EuReg protocol), a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group. MATERIALs AND METHODS: The data of 813 patients infected with H. pylori and entered in the Hp-EuReg register by the Russian centers in 2013-2015 were analyzed.
  
  
  RESULTS
  The most common methods for the primary diagnosis of H. pylori infection are histology (40.3%), rapid urease test (35.7%), and serology (17.2%). The duration of H. pylori eradication therapy was 7, 10, and 14 days in 18.0, 49.3, and 25.1%, respectively. To monitor the effectiveness of treatment, the investigators used a histological examination (34%), a urea breath test (27.3%), H. pylori stool antigen (22.8%), and a rapid urease test (16.3%). A serological test was carried out in 2.5% of the cases. No monitoring was done in 13.5% of the patients. The average eradication efficiency was 82.6%. If the therapy was ineffective, 80% of physicians did not intend to prescribe a new cycle of treatment.
  
  
  CONCLUSIONS
  Significant differences were found between clinical practice and the current guidelines.
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia; Tver State Medical University, Ministry of Health of Russia, Tver, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Bordin
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: O B
authors.initials: OB
authors.lastname: Yanova
authors.affiliation: Kazan State Medical University, Ministry of Health of Russia, Kazan, Russia.
authors.forename: R A
authors.initials: RA
authors.lastname: Abdulkhakov
authors.affiliation: Research Institute for Medical Problems of the North, Krasnoyarsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Tsukanov
authors.affiliation: Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Livzan
authors.affiliation: Polyclinic Three, Department for Presidential Affairs of the Russian Federation, Moscow, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Burkov
authors.affiliation: I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Zakharova
authors.affiliation: Kemerovo State Medical Academy, Ministry of Health of Russia, Kemerovo, Russia.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Plotnikova
authors.affiliation: Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
authors.forename: M F
authors.initials: MF
authors.lastname: Osipenko
authors.affiliation: Republican Gastroenterology Center, Republican Clinical Hospital, Ministry of Health and Social Development of Chuvashia, Cheboksary, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Tarasova
authors.affiliation: A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Maev
authors.affiliation: A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Kucheryavyi
authors.affiliation: I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia, Ryazan, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Butov
authors.affiliation: A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Russian Ministry for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters, Saint Petersburg, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Sablin
authors.affiliation: Tver State Medical University, Ministry of Health of Russia, Tver, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Kolbasnikov
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Voinovan
authors.affiliation: Kazan State Medical University, Ministry of Health of Russia, Kazan, Russia; Kazan Federal University, Kazan, Russia.
authors.forename: S R
authors.initials: SR
authors.lastname: Abdulkhakov
authors.affiliation: Research Institute for Medical Problems of the North, Krasnoyarsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Vasyutin
authors.affiliation: Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Lyalyukova
authors.affiliation: Polyclinic Three, Department for Presidential Affairs of the Russian Federation, Moscow, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Golubev
authors.affiliation: I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Savilova
authors.affiliation: Republican Gastroenterology Center, Republican Clinical Hospital, Ministry of Health and Social Development of Chuvashia, Cheboksary, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Grigoryeva
authors.affiliation: Tver State Medical University, Ministry of Health of Russia, Tver, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kononova
authors.affiliation: Department of Gastroenterology, Tallaght Hospital/Trinity College Dublin, Dublin, Ireland.
authors.forename: Colm
authors.initials: C
authors.lastname: O'Morain
authors.affiliation: Department of Gastroenterology, Instituto de Investigacion Sanitaria Princesa (IIS-IP), Hospital Universitario de la Princesa, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Ramas
authors.affiliation: Department of Gastroenterology, Instituto de Investigacion Sanitaria Princesa (IIS-IP), Hospital Universitario de la Princesa, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
authors.forename: Adrian G
authors.initials: AG
authors.lastname: Mcnicholl
authors.affiliation: Department of Gastroenterology, Instituto de Investigacion Sanitaria Princesa (IIS-IP), Hospital Universitario de la Princesa, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001944:Breath Tests / Q000379:methods; D002985:Clinical Protocols; D005060:Europe / Q000453:epidemiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012042:Registries / Q000706:statistics & numerical data; D012426:Russia / Q000453:epidemiology; D012680:Sensitivity and Specificity; D014510:Urease / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D014510:Urease