title: The altered right frontoparietal network functional connectivity in migraine and the modulation effect of treatment.
abstract: Aims This study aims to investigate the resting-state functional connectivity (rs-fc) of the right frontoparietal network (rFPN) between migraineurs and healthy controls (HCs) in order to determine how the rFPN rs-fc can be modulated by effective treatment. Methods One hundred patients and 46 matched HCs were recruited. Migraineurs were randomized to verum acupuncture, sham acupuncture, and waiting list groups. Resting-state functional magnetic resonance imaging data were collected before and after longitudinal treatments. Independent component analysis was applied in the data analysis. Results We found that migraineurs showed decreased rs-fc between the rFPN and bilateral precuneus compared with HCs. After treatments (real and sham), rFPN rs-fc with the precuneus was significantly reduced. This reduction was associated with headache intensity relief. In order to explore the role of the precuneus in acupuncture modulation, we performed a seed-based rs-fc analysis using the precuneus as a seed and found that the precuneus rs-fc with the bilateral rostral anterior cingulate cortex/medial prefrontal cortex, ventral striatum, and dorsolateral prefrontal cortex was significantly enhanced after treatment. Conclusion Our results suggest that migraineurs are associated with abnormal rFPN rs-fc. An effective treatment, such as acupuncture, may relieve symptoms by strengthening the cognitive adaptation/coping process. Elucidation of the adaptation/coping mechanisms may open up a new window for migraine management.
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.|2 Department of Traditional Chinese Medicine, Medical College of Xiamen University, Xiamen, Fujian, China.
authors.forename: Zhengjie
authors.initials: Z
authors.lastname: Li
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lan
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.affiliation: 3 Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.|4 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Nikos
authors.initials: N
authors.lastname: Makris
authors.affiliation: 5 School of Acupuncture-Moxibustion and Tuina, Beijing University of Traditional Chinese, Beijing, China.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Hwang
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Taipin
authors.initials: T
authors.lastname: Guo
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Gao
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Mingkai
authors.initials: M
authors.lastname: Dong
authors.affiliation: 6 Acupuncture and Tuina School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
authors.forename: Mailan
authors.initials: M
authors.lastname: Liu
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: 7 Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: 3 Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.|4 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Sun
authors.affiliation: 1 The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
authors.forename: Fanrong
authors.initials: F
authors.lastname: Liang
authors.affiliation: 3 Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.|4 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Kong
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000293:Adolescent; D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010296:Parietal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016896:Treatment Outcome; D055815:Young Adult
keywords: Acupuncture; fMRI; frontoparietal network; independent component analysis; migraine without aura; resting-state functional connectivity