title: Solubility enhancement of simvastatin by arginine: thermodynamics, solute-solvent interactions, and spectral analysis.
abstract: We examined the solubility of simvastatin in water in 0.01 mol·dm(-3), 0.02 mol·dm(-3), 0.04 mol·dm(-3), 0.09 mol·dm(-3), 0.18 mol·dm(-3), 0.36 mol·dm(-3), and 0.73 mol·dm(-3) arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies illustrated a higher extent of solubility enhancement for simvastatin. The aforementioned system was subjected to conductometric and volumetric measurements at temperatures (T) of 298.15 K, 303.15 K, 308.15 K, and 313.15 K to illustrate the thermodynamics involved and related solute-solvent interactions. The conductance values were used to evaluate the limiting molar conductance and association constants. Thermodynamic parameters (ΔG (0), ΔH (0), ΔS (0), and E s) for the association process of the solute in the aqueous solutions of ARG were calculated. Limiting partial molar volumes and expansibilities were evaluated from the density values. These values are discussed in terms of the solute-solvent and solute-cosolute interactions. Further, these systems were analyzed using ultraviolet-visible analysis, Fourier-transform infrared spectroscopy, and (13)C, (1)H, and two-dimensional nuclear overhauser effect spectroscopy nuclear magnetic resonance to complement thermophysical explanation.
authors.affiliation: Laboratory of Fundamental Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia; DDH Core, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor Darul Ehsan, Malaysia.
authors.forename: M M R
authors.initials: MM
authors.lastname: Meor Mohd Affandi
authors.affiliation: Laboratory of Fundamental Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia; Pharmaceutical and Life Sciences Core, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor Darul Ehsan, Malaysia.
authors.forename: Minaketan
authors.initials: M
authors.lastname: Tripathy
authors.affiliation: Pharmaceutical and Life Sciences Core, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor Darul Ehsan, Malaysia; Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia.
authors.forename: Syed Adnan Ali
authors.initials: SA
authors.lastname: Shah
authors.affiliation: Laboratory of Fundamental Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia; Pharmaceutical and Life Sciences Core, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor Darul Ehsan, Malaysia.
authors.forename: A B A
authors.initials: AB
authors.lastname: Majeed
mesh_terms: D001120:Arginine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D019821:Simvastatin / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D012997:Solvents; D014867:Water; D001120:Arginine; D019821:Simvastatin
keywords: conductometric; simvastatin–arginine complex; solubility; spectroscopy; volumetric