title: Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum.
abstract: The tolerability of a 2.5% lidocaine/prilocaine hydrogel (Nanorap, Biolab Indústria Farmacêutica Ltd., Sao Paulo, Brazil) was evaluated in 20 children ages 2 to 11 years undergoing cryotherapy for molluscum contagiosum (MC). The product was well tolerated, with only two children presenting with eczema at the application site. These adverse reactions were considered unlikely to be related to the test product, because a patch test was negative in one of the individuals and the other event occurred in only one of the two treated areas. Nanorap is an efficacious and well-tolerated option for topical anesthesia in children undergoing cryotherapy for MC.
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Sao Paulo, Brazil.
authors.forename: André A M
authors.initials: AA
authors.lastname: Gobbato
authors.affiliation: Galeno Research Unit, Campinas, Sao Paulo, Brazil.
authors.forename: Tainah
authors.initials: T
authors.lastname: Babadópulos
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Sao Paulo, Brazil.
authors.forename: Cintia A R S
authors.initials: CA
authors.lastname: Gobbato
authors.affiliation: Galeno Research Unit, Campinas, Sao Paulo, Brazil.|Faculty of Medical Sciences, Metropolitan University of Santos, Santos, Sao Paulo, Brazil.
authors.forename: Ronilson A
authors.initials: RA
authors.lastname: Moreno
authors.affiliation: Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Thiago
authors.initials: T
authors.lastname: Gagliano-Jucá
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Sao Paulo, Brazil.|Faculty of Medical Sciences, Metropolitan University of Santos, Santos, Sao Paulo, Brazil.
authors.forename: Gilberto
authors.initials: G
authors.lastname: De Nucci
mesh_terms: D000779:Anesthetics, Local / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D017679:Cryotherapy / Q000009:adverse effects* / Q000379:methods; D004338:Drug Combinations; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008976:Molluscum Contagiosum / Q000175:diagnosis* / Q000628:therapy*; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D011318:Prilocaine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D011318:Prilocaine; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008012:Lidocaine