title: A neoteric multidrug combination: novel approach to limited cutaneous systemic scleroderma involving the face.
abstract: Limited cutaneous scleroderma is a subtype of scleroderma limited to the skin of the face, hands, feet and forearms. We present a case of a 45-year-old woman affected by limited cutaneous systemic scleroderma involving the orofacial region and causing restricted mouth opening. The patient showed noteworthy improvement of the skin lesion by use of a combination of intralesional corticosteroid with hyaluronidase and various multiantioxidants, resulting in amelioration of her mouth opening problem. The patient gave her full informed written consent to this report being published.
authors.affiliation: Dental Department, Jeba Dental Clinic, Nagercoil, Tamilnadu, India.
authors.forename: M Hari
authors.initials: MH
authors.lastname: Kumar
authors.affiliation: Department of Maxillo Facial, Doctor Kamalkanadasan Dental Clinic, Chennai, Tamilnadu, India.
authors.forename: M Siva
authors.initials: MS
authors.lastname: Kumar
authors.affiliation: Dental Department, Jeba Dental Clinic, Nagercoil, Tamilnadu, India.
authors.forename: Sabitha Hari
authors.initials: SH
authors.lastname: Kumar
authors.affiliation: Dental Department, Jeba Dental Clinic, Nagercoil, Tamilnadu, India.
authors.forename: Kingsly Selva
authors.initials: KS
authors.lastname: Kumar
mesh_terms: D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005145:Face; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D009055:Mouth / Q000503:physiopathology; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology*; D014081:Tooth Extraction
chemical_list: D005938:Glucocorticoids; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone; D006821:Hyaluronoglucosaminidase