title: Metabolic role of lactobacilli in weight modification in humans and animals.
abstract: Obesity represents a worldwide public health crisis. Trials suggested that intestinal microbiota may contribute to the development of obesity and highlighted the involvement of bacteria, including Lactobacillus spp., in changes to the host metabolism. Several experiments have shown significant effects of Lactobacillus probiotics on weight modification. Lactobacillus spp. are involved in the digestion of complex carbohydrates not digested by the host in the colon and also participate in the degradation of lipids and simple sugars in the duodenum and jejunum. Moreover, Lactobacillus species survive throughout the gastrointestinal tract, as they are able to survive in the presence of bile and low pH, and produce an antimicrobial agent, allowing them to reduce the number of bacteria in the gut. Hence, Lactobacillus spp. can have a significant impact on microbiota and, consequently, on weight change. Here, we review current studies of Lactobacillus spp. involved in weight change and discuss the different mechanisms of action by which Lactobacillus spp. acts on host digestion and appears to influence weight.
authors.affiliation: Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, 13005, Marseille, France.
authors.forename: Fatima
authors.initials: F
authors.lastname: Drissi
authors.affiliation: Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, 13005, Marseille, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.affiliation: Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, 13005, Marseille, France. Electronic address: vicky_merhej@hotmail.com.
authors.forename: Vicky
authors.initials: V
authors.lastname: Merhej
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D001419:Bacteria / Q000187:drug effects; D001430:Bacteriocins; D001646:Bile; D001835:Body Weight; D050260:Carbohydrate Metabolism; D049109:Cell Proliferation; D003106:Colon / Q000378:metabolism / Q000382:microbiology; D004063:Digestion; D004386:Duodenum / Q000378:metabolism / Q000382:microbiology; D000069196:Gastrointestinal Microbiome / Q000187:drug effects / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007583:Jejunum / Q000378:metabolism / Q000382:microbiology; D007778:Lactobacillus / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology*; D050356:Lipid Metabolism; D055442:Metabolome; D009765:Obesity / Q000378:metabolism / Q000382:microbiology*; D019936:Probiotics / Q000627:therapeutic use; D011634:Public Health; D013045:Species Specificity; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D000890:Anti-Infective Agents; D001430:Bacteriocins
keywords: Bacteriocin; Carbohydrate; Lactobacillus; Lipid; Microbiota; Probiotic; Weight gain; Weight loss