title: The colorectal cancer immune paradox revisited.
abstract: Tumor infiltrating lymphocytes (TILs) represent a strong independent predictor of relapse and overall survival in colorectal cancer (CRC). However, it appears that a majority of CRCs, i.e., microsatellite stable (MSS) tumors, are refractory to immune checkpoint blockers. The results of recent comprehensive analyses of genomic data provide possible answers.
authors.affiliation: Biocenter, Division of Bioinformatics, Medical University of Innsbruck Innrain 80 , Innsbruck, Austria.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Angelova
authors.affiliation: Biocenter, Division of Bioinformatics, Medical University of Innsbruck Innrain 80 , Innsbruck, Austria.
authors.forename: Pornpimol
authors.initials: P
authors.lastname: Charoentong
authors.affiliation: Biocenter, Division of Bioinformatics, Medical University of Innsbruck Innrain 80 , Innsbruck, Austria.
authors.forename: Hubert
authors.initials: H
authors.lastname: Hackl
authors.affiliation: Biocenter, Division of Bioinformatics, Medical University of Innsbruck Innrain 80 , Innsbruck, Austria.
authors.forename: Z
authors.initials: Z
authors.lastname: Trajanoski
keywords: Immune escape; immunophenotype; tumor heterogeneity