title: Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon.
abstract: High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.
authors.affiliation: 1 Department of Hematology/Oncology, Mayo Clinic Cancer Center, Jacksonville, FL, USA ; 2 Department of Pathology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Hammond
authors.affiliation: 1 Department of Hematology/Oncology, Mayo Clinic Cancer Center, Jacksonville, FL, USA ; 2 Department of Pathology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Crozier
authors.affiliation: 1 Department of Hematology/Oncology, Mayo Clinic Cancer Center, Jacksonville, FL, USA ; 2 Department of Pathology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Raouf E
authors.initials: RE
authors.lastname: Nakhleh
authors.affiliation: 1 Department of Hematology/Oncology, Mayo Clinic Cancer Center, Jacksonville, FL, USA ; 2 Department of Pathology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Kabir
authors.initials: K
authors.lastname: Mody
keywords: Colon cancer; genomic profiling; neuroendocrine carcinoma