title: Pancreatic perivascular epithelioid cell tumor: A case report with clinicopathological features and a literature review.
abstract: Perivascular epithelioid cell tumor (PEComa) of the pancreas is an unusual tumor deriving from mesenchyma. This paper described a case of pancreatic PEComa, which was initially suspected as neuroendocrine carcinoma by biopsy, and therefore surgical treatment was recommended due to undetermined diagnosis. Examination of the surgical specimen under a microscope showed that the tumor cell's morphology was epithelioid or spindle-shaped, and ranged in a nested pattern. Additionally, these cells had a large extent of acidophilic cytoplasm, no mitotic figures, and expressed HMB-45, melan-p, and smooth muscle actin immunohistochemically. Pathological examination indicated that PEComa originated from the pancreas, but symptoms related to tuberous sclerosis were absent. Since PEComa is extremely rare in the pancreas, it is likely to be ignored in differential diagnosis. In conclusion, our article highlighted the clinicopathological features of PEComa, and we conducted a literature review focusing on PEComa so as to deepen the understanding of this tumor type.
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Na
authors.initials: N
authors.lastname: Ta
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Huang
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zhang
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xu
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Kai-Lian
authors.initials: KL
authors.lastname: Zheng
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Jin
authors.affiliation: Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Zheng
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D054973:Perivascular Epithelioid Cell Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Clinicopathological feature; HMB-45; Immunohistochemistry; Pancreas; Perivascular epithelioid cell tumor