title: A Multidimensional Computerized Adaptive Short-Form Quality of Life Questionnaire Developed and Validated for Multiple Sclerosis: The MusiQoL-MCAT.
abstract: The aim was to develop a multidimensional computerized adaptive short-form questionnaire, the MusiQoL-MCAT, from a fixed-length QoL questionnaire for multiple sclerosis.A total of 1992 patients were enrolled in this international cross-sectional study. The development of the MusiQoL-MCAT was based on the assessment of between-items MIRT model fit followed by real-data simulations. The MCAT algorithm was based on Bayesian maximum a posteriori estimation of latent traits and Kullback-Leibler information item selection. We examined several simulations based on a fixed number of items. Accuracy was assessed using correlations (r) between initial IRT scores and MCAT scores. Precision was assessed using the standard error measurement (SEM) and the root mean square error (RMSE).The multidimensional graded response model was used to estimate item parameters and IRT scores. Among the MCAT simulations, the 16-item version of the MusiQoL-MCAT was selected because the accuracy and precision became stable with 16 items with satisfactory levels (r ≥ 0.9, SEM ≤ 0.55, and RMSE ≤ 0.3). External validity of the MusiQoL-MCAT was satisfactory.The MusiQoL-MCAT presents satisfactory properties and can individually tailor QoL assessment to each patient, making it less burdensome to patients and better adapted for use in clinical practice.
authors.affiliation: From the Aix-Marseille University, EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit (PM, KB, BG, AL, MB, PA, LB); Aix-Marseille University - I2 M UMR 7373 - Mathematics Institute of Marseille (PM, BG); and Departments of Neurology and CRMBM CNRS6612, La Timone University Hospital, APHM, Marseille, France (JP).
authors.forename: Pierre
authors.initials: P
authors.lastname: Michel
authors.forename: Karine
authors.initials: K
authors.lastname: Baumstarck
authors.forename: Badih
authors.initials: B
authors.lastname: Ghattas
authors.forename: Jean
authors.initials: J
authors.lastname: Pelletier
authors.forename: Anderson
authors.initials: A
authors.lastname: Loundou
authors.forename: Mohamed
authors.initials: M
authors.lastname: Boucekine
authors.forename: Pascal
authors.initials: P
authors.lastname: Auquier
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
mesh_terms: D000328:Adult; D003201:Computers; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis*; D011788:Quality of Life; D011795:Surveys and Questionnaires