title: Cellular Homeostasis and Aging.
abstract: Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events that interface with environmental factors to maintain cellular homeostasis. Modulation of these pathways to extend life span, including insulin-like signaling and the response to dietary restriction, identified the cellular machineries and networks of protein homeostasis (proteostasis) and stress resistance pathways as critical players in the aging process. A decline of proteostasis capacity during aging leads to dysfunction of specific cell types and tissues, rendering the organism susceptible to a range of chronic diseases. This volume of the Annual Review of Biochemistry contains a set of two reviews addressing our current understanding of the molecular mechanisms underlying aging in model organisms and humans.
authors.affiliation: Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; email: uhartl@biochem.mpg.de.
authors.forename: F Ulrich
authors.initials: FU
authors.lastname: Hartl
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D031204:Caloric Restriction; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D055550:Protein Stability; D059748:Proteolysis; D057165:Proteostasis Deficiencies / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D056811:Unfolded Protein Response
chemical_list: D029742:Caenorhabditis elegans Proteins; D015852:Eukaryotic Initiation Factor-2; D014157:Transcription Factors; C474710:heat shock factor-1, C elegans; C529271:EIF2AK4 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: dietary restriction; insulin signaling; oxidative stress; protein homeostasis; proteostasis