title: THE EFFECT OF 2-BUTYL-CYANOACRYLATE ADHESIVE IN OSTEOTOMIES AND BONE GRAFTS IN RABBITS: MACROSCOPIC AND RADIOGRAPHIC CHARACTERISTICS.
abstract: OBJECTIVE
  To evaluate the effect of butyl-2-cyanoacrylate tissue adhesive in osteotomies and bone grafts, with regard to macroscopic and radiographic characteristics.
  
  
  METHODS
  Forty-eight rabbits were used, randomly divided into four groups of 12 animals, with observation periods of two, four, eight and 16 weeks. Both thoracic limbs were operated in each animal and two osteotomies were performed in each of the radii, withdrawing a bone fragment (bone graft) of 1 cm in length. On one side, the bone graft was then replaced and a drop of adhesive was applied to each of the osteotomies. On the other side, the same procedure was performed without applying the adhesive. The rejection level for the nullity hypothesis was set at 0.05% or 5%.
  
  
  RESULTS
  Blue marks were present in all the surgical specimens in which adhesive was applied. From the fourth week onwards, there was absence of movement of the bone grafts with adhesive and control. In group A, in the proximal osteotomies with adhesive, there was less deviation of the bone graft (p = 0.02). In group C, the union (p = 0.03) and the integration of the bone graft (p = 0.02) were better in the proximal osteotomies with adhesive.
  
  
  CONCLUSIONS
  The adhesive was not completely metabolized within 16 weeks. There was clinical consolidation of the osteotomies within four weeks. The adhesive stabilized the bone graft within the first weeks and did not interfere with the consolidation of the osteotomies, or the integration of the bone graft in radiographic observations.
authors.affiliation: Titular Professor of Orthopedics and Traumatology, UNIVÁS-FACIMPA, Pouso Alegre, MG, Brazil.
authors.forename: Mário Sérgio Viana
authors.initials: MS
authors.lastname: Xavier
authors.affiliation: Full Professor in the Department of Orthopedics, UNIFESP, São Paulo, SP, Brazil.
authors.forename: Vilnei Mattioli
authors.initials: VM
authors.lastname: Leite
keywords: Bone Transplantation; Enbucrilate; Osseointegration; Osteotomy; Polymerization; Tissue Adhesives