title: Acute Progression of Recurrent Meningioma during Luteinizing Hormone-Releasing Hormone Agonist Treatment for Prostate Cancer.
abstract: BACKGROUND
  Meningiomas are the most common type of benign brain tumor, and the incidence of meningioma in women is more than twofold higher than in men. Several studies have demonstrated that hormones are somehow related to the growth of meningiomas.
  
  
  METHODS
  A 72-year-old man with benign meningioma underwent tumor resection and had no recurrence for 18 years. He was found to have prostate cancer, and he received hormonal therapy with a luteinizing hormone-releasing hormone (LHRH) agonist. Two years later, he developed severe cognitive dysfunction and gait disturbance. Gadolinium-enhanced brain magnetic resonance imaging revealed a large recurrent mass and obstructive hydrocephalus. Staged resection was performed and stereotactic radiation therapy was administered against the residual tumor. His symptoms improved after endoscopic third ventriculostomy for obstructive hydrocephalus and his residual tumor remains stable.
  
  
  CONCLUSIONS
  This is the first report of a case in which an LHRH agonist promoted the growth of a pre-existing meningioma. We suggest that patients with a history of meningioma who are receiving LHRH agonist treatment should be closely monitored.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University Hospital, Ishikawa, Japan.
authors.forename: Taishi
authors.initials: T
authors.lastname: Tsutsui
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University Hospital, Ishikawa, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Miyashita
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University Hospital, Ishikawa, Japan.
authors.forename: Hemragul
authors.initials: H
authors.lastname: Sabit
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University Hospital, Ishikawa, Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Fukui
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University Hospital, Ishikawa, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University Hospital, Ishikawa, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizokami
authors.affiliation: Department of Pathology, Kanazawa University Hospital, Ishikawa, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: Department of Neurosurgery, Oumikusatsu Tokushukai Hospital, Shiga, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagatani
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University Hospital, Ishikawa, Japan. Electronic address: mnakada@med.kanazawa-u.ac.jp.
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakada
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000209:etiology; D018450:Disease Progression; D005682:Gadolinium / Q000493:pharmacokinetics; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D016729:Leuprolide / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D008579:Meningioma / Q000188:drug therapy / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D018365:Neoplasm, Residual / Q000601:surgery; D011471:Prostatic Neoplasms / Q000150:complications / Q000188:drug therapy*; D016634:Radiosurgery
chemical_list: D018931:Antineoplastic Agents, Hormonal; D019394:Ki-67 Antigen; D005682:Gadolinium; D016729:Leuprolide
keywords: LHRH agonist; Meningioma; Prostate cancer; Recurrence