title: Distribution of human single-nucleotide polymorphisms is approximated by the power law and represents a fractal structure.
abstract: Single-nucleotide polymorphisms (SNPs) are one of the main causes of evolution. The distribution of human SNPs, which were examined in detail genomewide, was analyzed. Three discrete databases of human SNPs were used for this analysis, and similar results were obtained from these databases. It was found that the distribution of the distance between SNPs was approximated by the power law, and the shape of the regions including SNPs had the so-called fractal structure. Although the reason why the distribution of SNPs obeys such a certain law of physics is unclear, a speculation was attempted in connection with the three-dimensional structure of human chromatin which has a fractal structure.
authors.affiliation: Department of Systems Medicine, Sakaguchi Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Gouda
authors.affiliation: Genome Research Center, NODAI Research Institute, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.
authors.forename: Yuh
authors.initials: Y
authors.lastname: Shiwa
authors.affiliation: Department of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Akashi
authors.affiliation: Genome Research Center, NODAI Research Institute, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.|Department of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: Chitose Laboratory Corp., Biotechnology Research Center, 907 Nogawa, Miyamae-ku, Kawasaki, 216-0001, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Kasahara
authors.affiliation: Chitose Laboratory Corp., Biotechnology Research Center, 907 Nogawa, Miyamae-ku, Kawasaki, 216-0001, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Furusawa
mesh_terms: D002843:Chromatin / Q000737:chemistry*; D030541:Databases, Genetic; D017709:Fractals; D015894:Genome, Human; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D002843:Chromatin