title: miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7.
abstract: MicroRNAs are highly conserved non-coding RNAs that regulate gene expression at the post-transcriptional level, and play pivotal roles in cancer development and progression. miR-100 has been reported to be significantly downregulated in a variety of cancers, including esophageal cancer. However, the role of miR-100 in human esophageal cancer has not been fully elucidated. We demonstrated that overexpression of miR-100 in esophageal cancer cells markedly inhibited cell proliferation, migration and invasion as well as tumor growth. We subsequently showed that CXCR7 is a direct target gene of miR-100. Our results indicated that miR-100 plays a tumor-suppressor role in esophageal cancer and suggest its potential application for esophageal cancer treatment.
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Shao-Mei
authors.initials: SM
authors.lastname: Zhou
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Xue-Bin
authors.initials: XB
authors.lastname: Chen
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Cao-Ming
authors.initials: CM
authors.lastname: Jun
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jing
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Deng-Xiong
authors.initials: DX
authors.lastname: Wei
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Yu-Bai
authors.initials: YB
authors.lastname: Zhou
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Xiang-Qian
authors.initials: XQ
authors.lastname: Xiao
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Run-Qing
authors.initials: RQ
authors.lastname: Jia
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Jing-Tao
authors.initials: JT
authors.lastname: Li
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Wang
authors.initials: W
authors.lastname: Sheng
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing 100124, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D004938:Esophageal Neoplasms / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D009361:Neoplasm Invasiveness; D054387:Receptors, CXCR / Q000235:genetics*
chemical_list: C501896:ACKR3 protein, human; C544266:MIRN100 microRNA, human; D035683:MicroRNAs; D054387:Receptors, CXCR