title: Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1.
abstract: OBJECTIVE
  To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats.
  
  
  METHODS
  Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and βg were given together at the same doses.
  
  
  RESULTS
  CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, βg treatment largely prevented oxidative and histopathological negative effects of CP.
  
  
  CONCLUSIONS
  Cisplatin has severe neurotoxic effects in rats and βg supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that βg might be useful against CP toxicity in patients with cancer in terms of nervous system.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman, Turkey.
authors.forename: Kürşat
authors.initials: K
authors.lastname: Kaya
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Ciftci
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Inönü University, Malatya, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Cetin
authors.affiliation: Department of Neurology, Faculty of Medicine, Inönü University, Malatya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tecellioğlu
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inönü University, Malatya, Turkey.
authors.forename: Neşe
authors.initials: N
authors.lastname: Başak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002945:Cisplatin / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D023421:Models, Animal; D018384:Oxidative Stress; D020011:Protective Agents / Q000494:pharmacology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D047071:beta-Glucans / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D020011:Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D047071:beta-Glucans; D002945:Cisplatin