title: [Celiac disease detection rate in gastroenterological patients].
abstract: OBJECTIVE
  To determine celiac disease detection rate in patients with digestive disease.
  
  
  METHODS
  A total of 318 gastroenterological patients admitted to be treated at the Central Research Institute of Gastroenterology in September to October 2012 were examined. The patients' age was 18 to 74 years (mean 51.5±16.4 years). Immunoglobulin A (IgA) and immunoglobulin G (IgG) anti-gliadin antibodies (AGA), IgA anti-tissue transglutaminase (anti-tTG) antibodies and IgG anti-tTG antibodies were determined. When the antibodies were elevated, esophagogastroduodenoscopy with duodenal biopsy was performed.
  
  
  RESULTS
  Forty-one of the 318 patients were found to have higher AGA (12.9%); out of them IgA AGA were in 17 (5.35%) patients and IgG AGA were also in 17 (5.35%). Elevated levels of both antibodies (IgA AGA and IgG AGA) were seen in 7 (2.2%) patients. Overall, the detection rate of increased AGA levels was 12.9%. The antibodies were more commonly higher in patients with liver diseases (21.8%) and in those with inflammatory bowel diseases (21.6%). Both IgA anti-tTG, IgG anti-tTG and IgA AGA, IgG AGA were detected in 6 (1.9%) of the 318 patients. The diagnosis of celiac disease was verified by duodenal histological examination in 3 (0.94%) of the 318 patients.
  
  
  CONCLUSIONS
  The celiac disease detection rate in gastroenterological patients was 0.94%.
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Bykova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Sabelnikova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: R B
authors.initials: RB
authors.lastname: Gudkova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Drozdov
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: P L
authors.initials: PL
authors.lastname: Shcherbakov
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Kirova
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Khomeriki
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: G G
authors.initials: GG
authors.lastname: Varvanina
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Belyaeva
authors.affiliation: Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Parfenov
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D015897:Comorbidity; D004386:Duodenum / Q000473:pathology*; D016145:Endoscopy, Digestive System / Q000379:methods; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology; D005767:Gastrointestinal Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins