title: Implantation of a Novel Allogeneic Mesenchymal Precursor Cell Type in Patients with Ischemic Cardiomyopathy Undergoing Coronary Artery Bypass Grafting: an Open Label Phase IIa Trial.
abstract: Heart failure is a life-limiting condition affecting over 40 million patients worldwide. Ischemic cardiomyopathy (ICM) is the most common cause. This study investigates in situ cardiac regeneration utilizing precision delivery of a novel mesenchymal precursor cell type (iMP) during coronary artery bypass surgery (CABG) in patients with ischemic cardiomyopathy (LVEF < 40 %). The phase IIa safety study was designed to enroll 11 patients. Preoperative scintigraphy imaging (SPECT) was used to identify hibernating myocardium not suitable for conventional myocardial revascularization for iMP implantation. iMP cells were implanted intramyocardially in predefined viable peri-infarct areas that showed poor perfusion, which could not be grafted due to poor target vessel quality. Postoperatively, SPECT was then used to identify changes in scar area. Intramyocardial implantation of iMP cells with CABG was safe with preliminary evidence of efficacy of improved myocardial contractility and perfusion of nonrevascularized territories resulting in a significant reduction in left ventricular scar area at 12 months after treatment. Clinical improvement was associated with a significant improvement in quality of life at 6 months posttreatment in all patients. The results suggest the potential for in situ myocardial regeneration in ischemic heart failure by delivery of iMP cells.
authors.affiliation: Cardiothoracic Department, AHEPA University Hospital, S. Kyriakidi 1, 546 36, Thessaloniki, Greece.
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Anastasiadis
authors.affiliation: Cardiothoracic Department, AHEPA University Hospital, S. Kyriakidi 1, 546 36, Thessaloniki, Greece. antonits@auth.gr.
authors.forename: Polychronis
authors.initials: P
authors.lastname: Antonitsis
authors.affiliation: The John Radcliffe Hospital, Oxford University Hospitals, Headington, Oxford, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Westaby
authors.affiliation: Experimental Therapeutics, University of Oxford, Oxford, UK.
authors.forename: Ajan
authors.initials: A
authors.lastname: Reginald
authors.affiliation: The John Radcliffe Hospital, Oxford University Hospitals, Headington, Oxford, UK.
authors.forename: Sabena
authors.initials: S
authors.lastname: Sultan
authors.affiliation: Department of Nuclear Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Argirios
authors.initials: A
authors.lastname: Doumas
authors.affiliation: First Cardiology Department, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Efthimiadis
authors.affiliation: School of Biosciences, Cardiff University, Wales, UK.
authors.forename: Martin John
authors.initials: MJ
authors.lastname: Evans
mesh_terms: D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D002478:Cells, Cultured; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003326:Coronary Circulation; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D010641:Phenotype; D011788:Quality of Life; D020127:Recovery of Function; D012038:Regeneration; D013318:Stroke Volume; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D016277:Ventricular Function, Left
keywords: Allogeneic; Coronary artery bypass grafting; Heart failure; Ischemic cardiomyopathy; Mesenchymal; Stem cells