title: Impact of thyroid autoimmunity on cumulative delivery rates in in vitro fertilization/intracytoplasmic sperm injection patients.
abstract: To predict the impact of thyroid autoimmunity (TAI) on the probability of delivery after a defined number of treatment cycles, using analysis of cumulative delivery rates in patients with and without TAI.
  
  
  
  Retrospective cohort study performed at the Center for Reproductive Medicine and Department of Endocrinology, University Hospital of Brussels, approved by the institutional review board of the hospital.
  
  
  
  University hospital.
  
  
  
  All patients who started their first IVF/intracytoplasmic sperm injection cycle at our fertility center between January 1, 2010 and December 31, 2011 were included.
  
  
  
  Live birth delivery after 25 weeks' gestation was taken as the primary endpoint of our study Cumulative delivery rates were calculated for both groups until six treatment cycles.
  
  
  
  All patients (in both groups) received the usual IVF treatment protocols (i.e., antagonist or agonist protocol).
  
  
  
  In total 2,406 women who consulted our center were included. We included 333 patients with TAI and 2019 patients without TAI. In the TAI group the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 65%. In our control the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 76%.
  
  
  
  Our study did not confirm an influence of TAI status in patients undergoing fertility treatment on cumulative delivery rates after six IVF/intracytoplasmic sperm injection cycles.
authors.affiliation: Department of Endocrinology, Universitair Ziekenhuis Brussel, Brussels, Belgium. Electronic address: david.unuane@uzbrussel.be.
authors.forename: David
authors.initials: D
authors.lastname: Unuane
authors.affiliation: Department of Endocrinology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Velkeniers
authors.affiliation: Department of Engineering and Statistics, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Sander
authors.initials: S
authors.lastname: Deridder
authors.affiliation: Department of Endocrinology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Bert
authors.initials: B
authors.lastname: Bravenboer
authors.affiliation: Department of Gynecology and Fertility, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Herman
authors.initials: H
authors.lastname: Tournaye
authors.affiliation: Department of Gynecology and Fertility, Universitair Ziekenhuis Brussel, Brussels, Belgium; Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Tivoli, La Louvière, Belgium.
authors.forename: Michael
authors.initials: M
authors.lastname: De Brucker
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D015551:Autoimmunity; D001530:Belgium; D015415:Biomarkers / Q000097:blood; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects; D006785:Hospitals, University; D006801:Humans; D007246:Infertility / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D007453:Iodide Peroxidase / Q000276:immunology; D033862:Iron-Binding Proteins / Q000276:immunology; D050498:Live Birth; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D013959:Thyroid Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*; D013963:Thyroid Hormones / Q000097:blood; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D033862:Iron-Binding Proteins; D013963:Thyroid Hormones; C056658:TPO protein, human; D007453:Iodide Peroxidase
keywords: Anti-TPO antibodies; cumulative delivery rates; hypothyroidism; thyroid autoimmunity