title: [Gastric and duodenal secretory and motor-evacuatory activity in patients with gastroesophageal reflux disease associated with different types of reflux].
abstract: OBJECTIVE
  To estimate esophageal and gastric pH values on an empty stomach and after stimulation of gastric secretion and gastric and duodenal motor-evacuatory activity in patients with gastroesophageal reflux disease (GERD) associated with pathological refluxes, such as gastroesophageal reflux (GER) and duodenogastroesophageal reflux (DGER).
  
  
  METHODS
  The observational cross-sectional study was conducted to investigate and compare the parameters of intraesophageal and intragastric pH metry and peripheral electrogastroenterography in 103 GERD patients with endoscopically positive distal reflux esophagitis in GER and DGER.
  
  
  RESULTS
  The patients with GERD developed pathological esophageal refluxes (both GER and DGER) in various degrees of impaired gastric production, from anacidity to hyperacidity. The patients with predominant DGER were found to have gastric hyperacidity and normal acidity slightly less frequently than those with predominant GER. The patients with GERD developing in the presence of predominant GER had moderate gastric stasis with discoordinated antroduodenal propulsion resulting from hypomotor dyskinesia of the stomach and duodenum. When DGER was predominant in the patients with GERD, the signs of gastric stasis and duodenal hyperkinesia were concurrent with discoordinated antroduodenal and duodenojejunal propulsion.
  
  
  CONCLUSIONS
  The specific features of the esophagogastroduodenal secretory and motor evacuatory disorders found create conditions for the pathological refluxes into the esophagus, which differ in the composition of refluxate.
authors.affiliation: Tver State Medical University, Ministry of Health of Russia, Tver, Russia.
authors.forename: G S
authors.initials: GS
authors.lastname: Dzhulay
authors.affiliation: Tver State Medical University, Ministry of Health of Russia, Tver, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Sekareva
mesh_terms: D000328:Adult; D000628:Aminophylline / Q000494:pharmacology*; D016145:Endoscopy, Digestive System / Q000379:methods; D050782:Esophageal pH Monitoring / Q000379:methods; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005750:Gastric Juice / Q000737:chemistry / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D013223:Statistics as Topic
chemical_list: D010726:Phosphodiesterase Inhibitors; D000628:Aminophylline