title: Healing Sacral Fracture Masquerading as Metastatic Bone Disease on a 68Ga-PSMA PET/CT.
abstract: Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein, which is frequently overexpressed on prostate cancer cells. A Ga-PSMA PET/CT can be used for early detection of lymph node or bone metastases after radical prostatectomy when there is biochemical recurrence. This report describes PSMA uptake in a healing fracture masquerading as metastatic bone disease in a patient with a history of prostate adenocarcinoma. Clinicians reporting Ga-PSMA PET/CT should be aware of this potential important pitfall.
authors.affiliation: From the Departments of *Nuclear Medicine and †Radiology, University Hospital Brussel, Belgium.
authors.forename: Pieterjan
authors.initials: P
authors.lastname: Gykiere
authors.forename: Lode
authors.initials: L
authors.lastname: Goethals
authors.forename: Hendrik
authors.initials: H
authors.lastname: Everaert
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D003937:Diagnosis, Differential; D017102:Fracture Healing; D050723:Fractures, Bone / Q000000981:diagnostic imaging* / Q000503:physiopathology; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D011471:Prostatic Neoplasms; D012447:Sacrum / Q000293:injuries*
chemical_list: D000954:Antigens, Surface; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II