title: Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy.
abstract: OBJECTIVE
  This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer.
  
  
  METHODS
  Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed.
  
  
  RESULTS
  The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029).
  
  
  CONCLUSIONS
  DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
authors.affiliation: Department of Colorectal Surgery, Yuan's General Hospital, Kaohsiung, Taiwan.|Department of Health Business Administration, Meiho University, Pingtung, Taiwan.
authors.forename: Tung-Bo
authors.initials: TB
authors.lastname: Chao
authors.affiliation: Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.|National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.|Department of Biotechnology, Southern Taiwan University of Science & Technology, Tainan, Taiwan.|Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Chien-Feng
authors.initials: CF
authors.lastname: Li
authors.affiliation: Division of Gastroenterology & Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.|Department of Leisure, Recreation, & Tourism Management, Southern Taiwan University of Science & Technology, Tainan, Taiwan.
authors.forename: Ching-Yih
authors.initials: CY
authors.lastname: Lin
authors.affiliation: Division of General Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.|Department of Health & Nutrition, Chia Nan University of Pharmacy & Science, Tainan, Taiwan.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Tian
authors.affiliation: Department of Pathology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: I-Wei
authors.initials: IW
authors.lastname: Chang
authors.affiliation: Division of Gastroenterology & Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Sheu
authors.affiliation: Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital & Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Ying-En
authors.initials: YE
authors.lastname: Lee
authors.affiliation: Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Ti-Chun
authors.initials: TC
authors.lastname: Chan
authors.affiliation: Department of Pathology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan.|Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan.
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: He
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods*; D051184:Desmoglein 3 / Q000032:analysis / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011379:Prognosis; D012004:Rectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; C071894:DSG3 protein, human; D051184:Desmoglein 3
keywords: DSG3; chemoradiotherapy; rectal cancer