title: Pharmacologic Treatment of Pediatric Hypertension.
abstract: Prevalence of hypertension is increasing in children and adolescents. Uncontrolled hypertension in children not only causes end organ damage but also increases the risk of adult hypertension and cardiovascular disease. Clinical trials have proven efficacy of antihypertensive medications in children. These medications are well tolerated by children with acceptable safety profile. The choice of agent is usually driven by underlying etiology of hypertension, profile of its side effects, and clinician's preference. This article will review currently available pediatric data on mechanism of action, common adverse effects, pediatric indication, recent clinical trial, and newer drugs in the common classes of antihypertensive medications.
authors.affiliation: Children's Hospital of Michigan/Wayne State University, 3901 Beaubien St., Detroit, MI, 48201, USA.
authors.forename: Rachita S
authors.initials: RS
authors.lastname: Dhull
authors.affiliation: Children's Hospital of Michigan/Wayne State University, 3901 Beaubien St., Detroit, MI, 48201, USA.
authors.forename: Rossana
authors.initials: R
authors.lastname: Baracco
authors.affiliation: Children's Hospital of Michigan/Wayne State University, 3901 Beaubien St., Detroit, MI, 48201, USA.
authors.forename: Amrish
authors.initials: A
authors.lastname: Jain
authors.affiliation: Children's Hospital of Michigan/Wayne State University, 3901 Beaubien St., Detroit, MI, 48201, USA. tmattoo@med.wayne.edu.
authors.forename: Tej K
authors.initials: TK
authors.lastname: Mattoo
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D012084:Renin-Angiotensin System / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D014665:Vasodilator Agents
keywords: Clinical trials; Dosing for hypertension; Hypertension; Hypertension in children; Pharmacologic management