title: ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality.
abstract: We examined the electrocardiographic (ECG) findings of centenarians and associated them with >360-day survival. Physical and functional assessment, resting electrocardiogram and laboratory tests were performed on 86 study participants 101.9 ± 1.2 years old (mean ± SD) (70 women, 16 men) and followed for at least 360 days. Centenarian ECGs were assessed for left ventricular hypertrophy (LVH) according to the Romhilt-Estes score, Sokolow-Lyon criteria and Cornell voltage criteria which were positive for 12.8, 6.98, and 10.5 % of participants, respectively. Fifty-two study participants (60 %) survived ≥360 days. Multivariate logistic regression analysis revealed a negative relationship between 360-day survival and the following: R II <0.45 mV adjusted for CRP (odds ratio (OR) = 0.108, 95 % confidence interval (CI) = 0.034-0.341, P < .001), R aVF < 0.35 mV adjusted for CRP (OR = 0.151, 95 % CI = 0.039-0.584, P < .006), Sokolow-Lyon voltage <1.45 mV adjusted for CRP (OR = 0.178, 95 % CI = 0.064-0.492, P = .001), QRS ≥90 ms adjusted for CRP (OR = 0.375, 95 % CI = 0.144-0.975, P = .044), and Romhilt-Estes score ≥5 points adjusted for sex and Barthel Index (OR = 0.459, 95 % CI = 0.212-0.993, P = .048) in single variable ECG models. QRS voltage correlated positively with systolic and pulse pressure, serum vitamin B12 level, sodium, calcium, phosphorous, TIMP-1, and eGFR. QRS voltage correlated negatively with BMI, WHR, serum leptin, IL-6, TNF-α, and PAI-1 levels. QRS complex duration correlated positively with CRP; QTc correlated positively with TNF-α. Results suggest that Romhilt-Estes LVH criteria scores ≥5 points, low ECG QRS voltages (Sokolow-Lyon voltage <1.45 mV), and QRS complexes ≥90 ms are predictive of centenarian 360-day mortality.
authors.affiliation: Department of Geriatrics, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland. jszewieczek@sum.edu.pl.
authors.forename: Jan
authors.initials: J
authors.lastname: Szewieczek
authors.affiliation: Department of Cardiology, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Gąsior
authors.affiliation: Department of Internal Medicine and Metabolic Diseases, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Duława
authors.affiliation: Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Francuz
authors.affiliation: Department of Internal Medicine and Metabolic Diseases, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Legierska
authors.affiliation: Department of Geriatrics, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Batko-Szwaczka
authors.affiliation: Department of Internal Nursing, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Hornik
authors.affiliation: Department of Internal Nursing, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Janusz-Jenczeń
authors.affiliation: Department of Internal Nursing, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Włodarczyk
authors.affiliation: Department of Geriatrics, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Wilczyński
mesh_terms: D000369:Aged, 80 and over; D000375:Aging; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000401:mortality* / Q000503:physiopathology; D008297:Male; D011044:Poland / Q000453:epidemiology; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Centenarians; ECG; Left ventricular hypertrophy; Low QRS voltage