title: Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis.
abstract: Neurotransmitter and receptor systems are involved in different neurological and neuropsychological disorders such as Parkinson&#039;s disease, depression, Alzheimer's disease and epilepsy. Recent advances in studies of signal transduction pathways or interacting proteins of neurotransmitter receptor systems suggest that different receptor systems may share the common signal transduction pathways or interacting proteins which may be better therapeutic targets for development of drugs to effectively control brain diseases. In this paper, we reviewed metabotropic glutamate receptors (mGluRs) and their related signal transduction pathways or interacting proteins in status epilepticus and temporal lobe epilepsy, and proposed some novel therapeutical drug targets for controlling epilepsy and epileptogenesis.
authors.forename: Feng
authors.initials: F
authors.lastname: Qian
authors.affiliation: Radiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore. tangfr@gmail.com.
authors.forename: Feng-Ru
authors.initials: FR
authors.lastname: Tang
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000378:metabolism*; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013226:Status Epilepticus / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000927:Anticonvulsants; D018683:Excitatory Amino Acid Agents; D018094:Receptors, Metabotropic Glutamate