title: Short sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis.
abstract: OBJECTIVE
  Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Several studies have suggested that short sleep duration could be a risk factor for NAFLD. However, results of those reports are inconsistent. This meta-analysis was conducted with an attempt to summarize all available data.
  
  
  METHODS
  A comprehensive literature review was performed using MEDLINE and EMBASE database. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of NAFLD among participants who had short sleep duration versus those with longer sleep duration were included. Pooled risk ratios and 95% confidence interval were calculated using a random-effect, generic inverse variance method.
  
  
  RESULTS
  Six studies met the eligibility criteria and were included in the meta-analysis. The risk of NAFLD in participants who had short sleep duration was significantly higher than participants with longer sleep duration with pooled risk ratios of 1.19 (95% confidence interval, 1.04-1.36, I2= 0%).
  
  
  CONCLUSIONS
  Our study demonstrated a small but significantly increased risk of NAFLD among participants who had short sleep duration.
authors.affiliation: Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York, USA.
authors.forename: Karn
authors.initials: K
authors.lastname: Wijarnpreecha
authors.affiliation: Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York, USA.
authors.forename: Charat
authors.initials: C
authors.lastname: Thongprayoon
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Panadeekarn
authors.initials: P
authors.lastname: Panjawatanan
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.|Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
mesh_terms: D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000209:etiology*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012890:Sleep; D012893:Sleep Wake Disorders / Q000150:complications* / Q000453:epidemiology; D013997:Time Factors
keywords: insomnia; meta-analysis; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; sleep duration