title: [Clinical features and pathophysiology of acute esophageal mucosal lesion].
abstract: Acute esophageal mucosal lesions (AEMLs) are categorized into black esophagitis (type B) and non-black esophagitis (type NB) on endoscopy. To clarify the distinct pathophysiology, we compared the clinical features and hematological findings at onset among 17 patients with type B esophagitis and 6 patients with type NB esophagitis. In type B esophagitis, time to endoscopy after onset was significantly shorter, and blood levels of lactate, urea nitrogen, creatinine, and glucose were higher than in type NB esophagitis. However, there were no significant intergroup differences in the incidences of other predisposing factors, such as diabetic ketoacidosis or esophageal hernias. These findings suggest that AEMLs are caused by acid reflux and peripheral vascular insufficiency, the latter being more associated with type B esophagitis by its etiology. In addition, blood lactate may indicate the severity of AEML, leading to black esophagitis.
authors.affiliation: Department of Gastroenterology, Kyushu Central Hospital.
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Ihara
authors.forename: Kazuoki
authors.initials: K
authors.lastname: Hizawa
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fujita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Matsuno
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sakuma
authors.forename: Motohiro
authors.initials: M
authors.lastname: Esaki
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004941:Esophagitis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology