title: hsa-miR-9 controls the mobility behavior of glioblastoma cells via regulation of MAPK14 signaling elements.
abstract: BACKGROUND
  Glioblastoma Multiforme (GBM) is the most common and lethal primary tumor of the brain. GBM is associated with one of the worst 5-year survival rates among all human cancers, despite much effort in different modes of treatment.
  
  
  RESULTS
  Here, we demonstrate specific GBM cancer phenotypes that are governed by modifications to the MAPAKAP network. We then demonstrate a novel regulation mode by which a set of five key factors of the MAPKAP pathway are regulated by the same microRNA, hsa-miR-9.We demonstrate that hsa-miR-9 overexpression leads to MAPKAP signaling inhibition, partially by interfering with the MAPK14/MAPKAP3 complex. Further, hsa-miR-9 overexpression initiates re-arrangement of actin filaments, which leads us to hypothesize a mechanism for the observed phenotypic shift.
  
  
  CONCLUSIONS
  The work presented here exposes novel microRNA features and situates hsa-miR-9 as a therapeutic target, which governs metastasis and thus determines prognosis in GBM through MAPKAP signaling.
authors.affiliation: The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat-Gan, Israel.
authors.forename: Rotem
authors.initials: R
authors.lastname: Ben-Hamo
authors.affiliation: The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat-Gan, Israel.
authors.forename: Alona
authors.initials: A
authors.lastname: Zilberberg
authors.affiliation: The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat-Gan, Israel.
authors.forename: Helit
authors.initials: H
authors.lastname: Cohen
authors.affiliation: The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat-Gan, Israel.
authors.forename: Sol
authors.initials: S
authors.lastname: Efroni
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D048308:Mitogen-Activated Protein Kinase 14 / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D015398:Signal Transduction; D015996:Survival Rate; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; C541874:MIRN92 microRNA, human; D035683:MicroRNAs; D048308:Mitogen-Activated Protein Kinase 14
keywords: MAPKAP signaling; cytoskeleton; glioblastoma; hsa-miR9; metastasis; pathways