title: Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists Utilizing Data from the Exenatide Clinical Trial Development Program.
abstract: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated benefits for patients with type 2 diabetes including A1C reduction and weight loss with minimal risk of hypoglycemia. This article provides an evidence-based update of safety and tolerability considerations for the clinical use of GLP-1RAs as a class, with a specific detailed review of data from the exenatide clinical trial development program, which has the longest history and availability of safety and tolerability data as the first-approved GLP-1RA. Specific areas covered include comparative risk of hypoglycemia, as well as pancreatic, thyroid, and cardiovascular safety data; clinical guidance regarding current safety and tolerability data is also reviewed.
authors.affiliation: MedStar Health Research Institute, 6562 Belcrest Rd, Suite 700, Hyattsville, MD, 20782, USA.|MedStar Washington Hospital Center, Washington, DC, USA.|Georgetown University School of Medicine, Washington, DC, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.affiliation: MedStar Health Research Institute, 6562 Belcrest Rd, Suite 700, Hyattsville, MD, 20782, USA.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Want
authors.affiliation: MedStar Health Research Institute, 6562 Belcrest Rd, Suite 700, Hyattsville, MD, 20782, USA. vanita.aroda@medstar.net.|Georgetown University School of Medicine, Washington, DC, USA. vanita.aroda@medstar.net.
authors.forename: Vanita R
authors.initials: VR
authors.lastname: Aroda
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D006801:Humans; D007003:Hypoglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
chemical_list: D000906:Antibodies; D007004:Hypoglycemic Agents; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
keywords: Cardiovascular; Exenatide; GLP-1 receptor agonists; Incretin; Pancreatitis; Safety