title: Biodegradable polymeric stents for vascular application in a porcine carotid artery model: English version.
abstract: Over the past years the development of biodegradable polymeric stents has made great progress; nevertheless, essential problems must still be solved. Modifications in design and chemical composition should optimize the quality of biodegradable stents and remove the weaknesses. New biodegradable poly-L-lactide/poly-4-hydroxybutyrate (PLLA/P4HB) stents and permanent 316L stents were implantedendovascularly into both common carotid arteries of 10 domestic pigs. At 4 weeks following implantation, computed tomography (CT) angiography was carried out to identify the distal degree of stenosis. The PLLA/P4HB group showed a considerably lower distal degree of stenosis by additional oral application of atorvastatin (mean 39.81 ± 8.57 %) compared to the untreated PLLA/P4HB group without atorvastatin (mean 52.05 ± 5.80 %). The 316L stents showed no differences in the degree of distal stenosis between the group treated with atorvastatin (mean 44.21 ± 2.34 %) and the untreated group (mean 35.65 ± 3.72 %). Biodegradable PLLA/P4HB stents generally represent a promising approach to resolving the existing problems in the use of permanent stents. Restitutio ad integrum is only achievable if a stent is completely degraded.
authors.affiliation: Klinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Kischkel
authors.affiliation: Institut für Biomedizinische Technik, Universitätsmedizin Rostock, Rostock, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Grabow
authors.affiliation: Klinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Püschel
authors.affiliation: Klinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Erdle
authors.affiliation: Klinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kabelitz
authors.affiliation: TEPHA, Inc., Lexington, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Martin
authors.affiliation: TEPHA, Inc., Lexington, USA.
authors.forename: S F
authors.initials: SF
authors.lastname: Williams
authors.affiliation: Institut für Diagnostische und Interventionelle Radiologie, Universitätsmedizin Rostock, Rostock, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Bombor
authors.affiliation: Institut für Biomedizinische Technik, Universitätsmedizin Rostock, Rostock, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Sternberg
authors.affiliation: Institut für Biomedizinische Technik, Universitätsmedizin Rostock, Rostock, Germany.
authors.forename: K-P
authors.initials: KP
authors.lastname: Schmitz
authors.affiliation: Klinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Schareck
authors.affiliation: Klinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany ; Klinik für Gefäßmedizin, Vivantes Klinikum Humboldt, Berlin, Germany.
authors.forename: C M
authors.initials: CM
authors.lastname: Bünger
keywords: Atorvastatin; Biodegradable stents; Common carotid artery; Poly(4-hydroxybutyrate); Poly(L-lactide)