title: SRPK2 promotes the growth and migration of the colon cancer cells.
abstract: Colon cancer is one of the major causes of cancer-related death in the world. Understanding the molecular mechanism underlying this malignancy will facilitate the diagnosis and treatment. Serine-arginine protein kinase 2 (SRPK2) has been reported to be upregulated in several cancer types. However, its expression and functions in colon cancer remains unknown. In this study, it was found that the expression of SRPK2 was up-regulated in the clinical colon cancer samples. Overexpression of SRPK2 promoted the growth and migration of colon cancer cells, while knocking down the expression of SRPK2 inhibited the growth, migration and tumorigenecity of colon cancer cells. Molecular mechanism studies revealed that SRPK2 activated ERK signaling in colon cancer cells. Taken together, our study demonstrated the tumor promoting roles of SRPK2 in colon cancer cells and SRPK2 might be a promising therapeutic target for colon cancer.
authors.affiliation: Department of Gastrointestinal Surgery, Huai'an Hospital Affiliated of Xuzhou Medical College and Huai'an Second People's Hospital, No. 62, Huai-hai South Road, Hua'an, 223200, Jiangsu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine, Affiliated Yixing People's Hospital, Jiangsu University, No. 75, Tongzhenguan Road, Yixing, 214200, Jiangsu, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, Jiangsu Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.affiliation: Department of Gastroenterology, Huai'an Hospital Affiliated of Xuzhou Medical College and Huai'an Second People's Hospital, No. 62, Huai-hai South Road, Huai'an, 223200, Jiangsu, China.
authors.forename: Dong-Yan
authors.initials: DY
authors.lastname: Xu
authors.affiliation: Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu Province, China.
authors.forename: Ting-Yan
authors.initials: TY
authors.lastname: Ruan
authors.affiliation: Department of General Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, Jiangsu Province, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Tao
authors.affiliation: Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu Province, China. Electronic address: lupeihua0902@sina.com.
authors.forename: Pei-Hua
authors.initials: PH
authors.lastname: Lu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D020935:MAP Kinase Signaling System; D051379:Mice; D008819:Mice, Nude; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism*
chemical_list: C482119:BRAF protein, human; D017346:Protein Serine-Threonine Kinases; D048493:Proto-Oncogene Proteins B-raf; C110522:SRPK2 protein, human
keywords: Cell growth and migration; Colon cancer; ERK; SRPK2