title: Structural ECM components in the premetastatic and metastatic niche.
abstract: The aim of this review is to give an overview of the extracellular matrix (ECM) components that are important for creating structural changes in the premetastatic and metastatic niche. The successful arrival and survival of cancer cells that have left the primary tumor and colonized distant sites depends on the new microenvironment they encounter. The primary tumor itself releases factors into the circulation that travel to distant organs and then initiate structural changes, both non-enzymatic and enzymatic, to create a favorable niche for the disseminating tumor cells. Therapeutic strategies aimed at targeting cell-ECM interactions may well be one of the best viable approaches to combat metastasis and thus improve patient care.
authors.affiliation: Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anette M
authors.initials: AM
authors.lastname: Høye
authors.affiliation: Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark janine.erler@bric.ku.dk.
authors.forename: Janine T
authors.initials: JT
authors.lastname: Erler
mesh_terms: D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D002470:Cell Survival; D055354:Exosomes / Q000378:metabolism / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D059467:Transcriptome; D000072258:Tumor Hypoxia; D059016:Tumor Microenvironment
chemical_list: D016326:Extracellular Matrix Proteins
keywords: ECM; matrisome; metastatic; niche; premetastatic