title: Nanocomposite of bimetallic nanodendrite and reduced graphene oxide as a novel platform for molecular imprinting technology.
abstract: In this present work, for the first time, we are reporting a green synthesis approach for the preparation of vinyl modified reduced graphene oxide-based magnetic and bimetallic (Fe/Ag) nanodendrite (RGO@BMNDs). Herein, the RGO@BMNDs acts as a platform for the synthesis of the pyrazinamide (PZA)-imprinted polymer matrix and used for designing of the electrochemical sensor. We have demonstrated how the change in morphology could affect the electrochemical and magnetic property of nanomaterials and for this the reduced graphene oxide-based bimetallic nanoparticle (Fe/Ag) was also prepared It was found that the combination of graphene and bimetallic nanodendrites shows improvement as well as enhancement in the electrocatalytic activity and adsorption capacity, in comparison to their respective nanoparticles. The application of imprinted-RGO@BMNDs sensor was explored for trace level detection of PZA (Limit of detection = 6.65 pg L(-1), S/N = 3), which is a drug used for the cure of Tuberculosis. This is lowest detection limit reported so far for the detection of PZA. The sensor is highly selective, cost-effective, simple and free from any interfering effect. The real time application of the sensor was explored by successful detection of PZA in pharmaceutical and human blood serum, plasma and urine samples.
authors.affiliation: Department of Applied Chemistry, Indian School of Mines, Dhanbad, Jharkhand 826 004, India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Patra
authors.affiliation: Department of Applied Chemistry, Indian School of Mines, Dhanbad, Jharkhand 826 004, India.
authors.forename: Ekta
authors.initials: E
authors.lastname: Roy
authors.affiliation: Department of Applied Chemistry, Indian School of Mines, Dhanbad, Jharkhand 826 004, India. Electronic address: rshmmadhuri@gmail.com.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Madhuri
authors.affiliation: Functional Nanomaterials Research Laboratory, Department of Applied Physics, Indian School of Mines, Dhanbad, Jharkhand 826 004, India.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Sharma
mesh_terms: D006108:Graphite / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D054802:Molecular Imprinting; D053761:Nanocomposites; D010087:Oxides / Q000737:chemistry; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D010087:Oxides; D006108:Graphite
keywords: Bimetallic nanodendrite; Imprinted sensor; Pyrazinamide; Real sample analysis; Reduced graphene oxide