title: Effects of gliclazide add on metformin on serum omentin-1 levels in patients with type 2 diabetes mellitus.
abstract: BACKGROUND
  Omentin is a newly identified adipokine that has beneficial influence against cardiovascular disorders. Hence, considering the impact of anti-diabetic drug on omentin levels may provide an adjuvant strategy to protect diabetic patients against valuable clinical hazards.
  
  
  OBJECTIVE
  To investigate the influence of metformin alone or in combination with gliclazide on the level of serum omentin among patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  A total of 70 newly diagnosed patients with T2DM were enrolled in this randomized, double-blind prospective study, and divided into two equal groups based on treatment regimen in which Group 1 treated with metformin (1000 mg) and Group 2 treated with metformin (1000 mg) plus gliclazide (80 mg). Blood glucose levels, HbA1C, insulin levels, and serum omentin-1 were measured at baseline and after 12 weeks of treatment.
  
  
  RESULTS
  Use of gliclazide as an add-on therapy to metformin in patients with T2DM result in better glycemic control evidenced by significant reductions in the levels of blood glucose levels and HbA1C and much more improvement in insulin sensitivity evidenced by significant decreased in insulin resistance index, whereas it has adverse impact on serum omentin-1 levels evidenced by significant decrement in omentin-1 level in comparison to their pretreatment levels among Group 2 patients.
  
  
  CONCLUSIONS
  Adding of gliclazide to metformin in treatment of patients with T2DM might extend the therapeutic action of metformin in regarding much better controlling of glycemic indices, but, at the same time, it might attenuate the cardioprotective effects of metformin by its adverse influence on serum omentin-1 levels.
authors.affiliation: Department of Clinical Pharmacology and Therapeutics, Al-Mustansiriya University, Baghdad, Iraq.
authors.forename: Ali I
authors.initials: AI
authors.lastname: Al-Gareeb
authors.affiliation: Department of Internal Medicine, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
authors.forename: Haidar F
authors.initials: HF
authors.lastname: Alrubai
authors.affiliation: Department of Clinical Pharmacy, Al-Yarmouk Teaching Hospital, Baghdad, Iraq.
authors.forename: Sammar M
authors.initials: SM
authors.lastname: Suliaman
keywords: Diabetes mellitus; gliclazide; metformin; omentin-1