title: Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population.
abstract: BACKGROUND
  The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.
  
  
  OBJECTIVE
  The aim of this study was to validate the KSQ in a Dutch sarcoidosis population.
  
  
  METHODS
  The KSQ was translated according to international guidelines and tested in interviews with patients. Consecutive outpatients completed multiple questionnaires twice, two weeks apart. Construct validity, internal consistency and repeatability were determined.
  
  
  RESULTS
  Of the 98 patients included 85 had lung, 22 skin and 24 eye disease. There was good construct validity of the KSQ General Health Status module against the World Health Organization Quality of Life-BREF questionnaire. The Medication module correlated weak to moderate with most questionnaires. The correlations with organ-specific questionnaires varied from strong for Eyes (r=0.75), Skin (r=-0.62) to moderate for Lung (r=-0.45 with MRC breathlessness scale). Internal consistency was good for all KSQ modules (Cronbach's α 0.72-0.93). Intraclass correlation coefficients (0.70-0.90) and Bland-Altman plots showed good repeatability of the KSQ.
  
  
  CONCLUSIONS
  The Dutch KSQ is the first translation of the English KSQ, validated in a Dutch sarcoidosis population.
authors.affiliation: ¹Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.. m.j.g.vanmanen@erasmusmc.nl.
authors.forename: Mirjam J G
authors.initials: MJ
authors.lastname: Van Manen
authors.forename: Monique
authors.initials: M
authors.lastname: Wapenaar
authors.forename: Bert
authors.initials: B
authors.lastname: Strookappe
authors.forename: Marjolein
authors.initials: M
authors.lastname: Drent
authors.forename: Marjon
authors.initials: M
authors.lastname: Elfferich
authors.forename: Jolanda
authors.initials: J
authors.lastname: de Vries
authors.forename: Harry R
authors.initials: HR
authors.lastname: Gosker
authors.forename: Surinder S
authors.initials: SS
authors.lastname: Birring
authors.forename: Amit S
authors.initials: AS
authors.lastname: Patel
authors.forename: Leon
authors.initials: L
authors.lastname: van den Toorn
authors.forename: Bernt
authors.initials: B
authors.lastname: van den Blink
authors.forename: Karin
authors.initials: K
authors.lastname: Boomars
authors.forename: Elske
authors.initials: E
authors.lastname: Hoitsma
authors.forename: Marlies S
authors.initials: MS
authors.lastname: Wijsenbeek
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D012507:Sarcoidosis / Q000175:diagnosis*; D057566:Self Report; D014177:Translations
keywords: Sarcoidosis, Health status, Questionnaire, Quality of Life