title: Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy.
abstract: A mixture of docetaxel (DTX) and Solutol(®) HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea.
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Oh
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea.
authors.forename: Kyungim
authors.initials: K
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea.
authors.forename: Byeong Deok
authors.initials: BD
authors.lastname: Yoon
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea.
authors.forename: Dal Yong
authors.initials: DY
authors.lastname: Park
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea.
authors.forename: Eun-Yeong
authors.initials: EY
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea.
authors.forename: Kiho
authors.initials: K
authors.lastname: Lee
authors.affiliation: Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea.
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Seo
authors.affiliation: College of Pharmacy, Korea University, Sejong, Republic of Korea; Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea.
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D000077143:Docetaxel; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods; D008297:Male; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols; D013229:Stearic Acids; D043823:Taxoids / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D013229:Stearic Acids; D043823:Taxoids; D020442:Poloxamer; D000077143:Docetaxel; D011092:Polyethylene Glycols; C067028:Solutol HS 15
keywords: Pluronic F-68; Solutol; cancer therapy; docetaxel; multilayer nanoparticles