title: Factors Associated With New-Onset Depression After Stroke.
abstract: To better identify stroke survivors at risk for depression who may benefit from early prevention through targeted strategies in the acute-subacute poststroke period, we examined 118 Framingham Heart Study stroke survivors with longitudinal prestroke depression assessments. Among those who developed poststroke depression, most lacked a history of depressive symptoms 5 years prior to their stroke. Sex (female), advanced age, and prestroke factors (smoking and functional dependence) were associated with new-onset depression poststroke. These findings suggest fully characterizing and accounting for prestroke factors, including psychosocial and behavioral determinants, may inform the predictive modeling needed to determine whether targeted preventive trials early in stroke recovery will improve stroke outcomes.
authors.affiliation: From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (JS, JR); The Framingham Heart Study, Boston (AB, JJH, SS); the Department of Biostatistics, Boston University School of Medicine, Boston (AB); the Department of Neurology, Boston University School of Medicine, Boston (AB, SS); and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ECD).
authors.forename: Joel
authors.initials: J
authors.lastname: Salinas
authors.affiliation: From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (JS, JR); The Framingham Heart Study, Boston (AB, JJH, SS); the Department of Biostatistics, Boston University School of Medicine, Boston (AB); the Department of Neurology, Boston University School of Medicine, Boston (AB, SS); and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ECD).
authors.forename: Alexa
authors.initials: A
authors.lastname: Beiser
authors.affiliation: From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (JS, JR); The Framingham Heart Study, Boston (AB, JJH, SS); the Department of Biostatistics, Boston University School of Medicine, Boston (AB); the Department of Neurology, Boston University School of Medicine, Boston (AB, SS); and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ECD).
authors.forename: Jayandra J
authors.initials: JJ
authors.lastname: Himali
authors.affiliation: From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (JS, JR); The Framingham Heart Study, Boston (AB, JJH, SS); the Department of Biostatistics, Boston University School of Medicine, Boston (AB); the Department of Neurology, Boston University School of Medicine, Boston (AB, SS); and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ECD).
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.affiliation: From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (JS, JR); The Framingham Heart Study, Boston (AB, JJH, SS); the Department of Biostatistics, Boston University School of Medicine, Boston (AB); the Department of Neurology, Boston University School of Medicine, Boston (AB, SS); and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ECD).
authors.forename: Sudha
authors.initials: S
authors.lastname: Seshadri
authors.affiliation: From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (JS, JR); The Framingham Heart Study, Boston (AB, JJH, SS); the Department of Biostatistics, Boston University School of Medicine, Boston (AB); the Department of Neurology, Boston University School of Medicine, Boston (AB, SS); and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ECD).
authors.forename: Erin C
authors.initials: EC
authors.lastname: Dunn