title: Combinatorial Dansyl Library and its Applications to pH-Responsive Probes.
abstract: Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.
authors.forename: Seong Cheol
authors.initials: SC
authors.lastname: Hong
authors.forename: Dhiraj P
authors.initials: DP
authors.lastname: Murale
authors.affiliation: Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), P.O. Box: 136-791, Seoul, Republic of Korea. junseoklee@kist.re.kr.
authors.forename: Jun-Seok
authors.initials: JS
authors.lastname: Lee
mesh_terms: D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D020650:Combinatorial Chemistry Techniques; D003619:Dansyl Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D054852:Small Molecule Libraries / Q000737:chemistry*
chemical_list: D003619:Dansyl Compounds; D005456:Fluorescent Dyes; D054852:Small Molecule Libraries