title: The influence of steatosis on the short- and long-term results of resection of liver metastases from colorectal carcinoma.
abstract: We aimed to establish whether the presence of hepatic steatosis influences outcome after resection of colorectal liver metastases (CLM).
  
  
  METHODS
  Patients operated between 1990 and 2014 were divided into four groups based on the degree of hepatic steatosis. The association between hepatic steatosis and outcome was analyzed, using a multivariate and a propensity score case-match analysis.
  
  
  RESULTS
  No significant differences were observed between patients with and without steatosis in either mortality or morbidity in the complete series or after matching (3.2% vs. 3.5%/p = 0.845) (32.3% vs 31.4%/p = 0.802). Five-year survival in patients with and without steatosis were 56.5% and 46.5% respectively (p = 0.046). The steatosis had a significant protective effect in the univariate analysis (HR (95% CI) = 0.78 (0.62-0.99) p = 0.048), and was close to significance in the multivariate analysis (HR (95%) = 0.81 (0.63-1.03) p = 0.089). No significant differences were seen with regard to liver recurrence.
  
  
  CONCLUSIONS
  The presence of steatosis does not predict short-outcome after resection of CLM, but appears to be a favorable prognostic factor for survival. This protective effect does not depend on a decrease in liver recurrence.
authors.affiliation: Hospital Universitario de Bellvitge, Department of General Surgery, Spain. Electronic address: eramos@bellvitgehospital.cat.
authors.forename: Emilio
authors.initials: E
authors.lastname: Ramos
authors.affiliation: Hospital Universitario de Bellvitge, Department of General Surgery, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Torras
authors.affiliation: Hospital Universitario de Bellvitge, Department of General Surgery, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Lladó
authors.affiliation: Hospital Universitario de Bellvitge, Department of General Surgery, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Rafecas
authors.affiliation: Department of Pathology, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Serrano
authors.affiliation: Hospital Universitario de Bellvitge, Department of General Surgery, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Lopez-Gordo
authors.affiliation: Hospital Universitario de Bellvitge, Department of General Surgery, Spain.
authors.forename: Juli
authors.initials: J
authors.lastname: Busquets
authors.affiliation: Hospital Universitario de Bellvitge, Department of General Surgery, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Fabregat
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000150:complications / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000150:complications / Q000401:mortality / Q000473:pathology*; D016208:Databases, Factual; D005234:Fatty Liver / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000150:complications / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D059146:Metastasectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D015999:Multivariate Analysis; D057216:Propensity Score; D016016:Proportional Hazards Models; D065840:Protective Factors; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome