title: Nesfatin-1 hormone levels in morbidly obese patients after laparoscopic sleeve gastrectomy.
abstract: OBJECTIVE
  To investigate changes in body mass index (BMI) and nesfatin-1 levels in patients with morbid obesity who had undergone laparoscopic sleeve gastrectomy (LSG).
  
  
  METHODS
  Blood samples were collected from, and the BMI calculated of 30 morbidly obese patients pre-surgery and at 3 and 6 months post-surgery. Nesfatin-1 hormone levels were measured using enzyme-linked immunosorbent assay (ELISA). Descriptive statistical analysis of the data was performed using Kruskal-Wallis variance analysis, one-way ANOVA, and the Bonferroni-Dunn test. The correlations between continuous variables not displaying normal distribution and those displaying normal distributions were analyzed using the Spearman correlation test and the Pearson correlation test, respectively.
  
  
  RESULTS
  The mean age of the 30 patients was 41.23 ± 10.37 years. The mean BMI values (kg/m2) were 49.30 ± 7.92, 39,48 ± 7.32, and 34.39 ± 7.56 presurgery, three months post-surgery, and six months post-surgery, respectively (p < 0.001). Mean nesfatin-1 levels (ng/ml) were 22.80 ± 14.16, 60.23 ± 52.92, and 96.99 ± 40.20 presurgery, three months post-surgery, and six months post-surgery, respectively (p < 0.001). The postoperative months 3 and 6 BMI values were significantly lower than the preoperative BMI value and the postoperative month 6 BMI value was significantly lower than the postoperative month 3 BMI value (p < 0.001). The postoperative months 3 and 6 nesfatin-1 levels were significantly higher than the preoperative nesfatin-1 levels. A negative correlation was found between age and preoperative nesfatin-1 values (p = 0.001, r = -0.0557).
  
  
  CONCLUSIONS
  Observation of significant increases in nesfatin-1 hormone levels in morbidly obese patients who had undergone LSG indicate that nesfatin-1 has important anorexigenic effects post-surgery and may be an important component of future obesity treatments.
authors.affiliation: General Surgery Department, Antalya Training and Research Hospital, Antalya, Turkey. ugurdoga1@hotmail.com.
authors.forename: U
authors.initials: U
authors.lastname: Dogan
authors.forename: N
authors.initials: N
authors.lastname: Bulbuller
authors.forename: T
authors.initials: T
authors.lastname: Cakır
authors.forename: M
authors.initials: M
authors.lastname: Habibi
authors.forename: B
authors.initials: B
authors.lastname: Mayir
authors.forename: U
authors.initials: U
authors.lastname: Koc
authors.forename: A
authors.initials: A
authors.lastname: Aslaner
authors.forename: H Y
authors.initials: HY
authors.lastname: Ellidag
authors.forename: I
authors.initials: I
authors.lastname: Gomceli
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D005743:Gastrectomy / Q000639:trends*; D006801:Humans; D010535:Laparoscopy / Q000639:trends*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D009767:Obesity, Morbid / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D011182:Postoperative Care / Q000639:trends; D011300:Preoperative Care / Q000639:trends
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins