title: A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice.
abstract: Three genes of the prion protein gene family are expressed in gonads. Comparative analyses of their expression patterns in mice and goats revealed constant expression of PRNP and SPRN in both species and in both male and female gonads, but with a weaker expression of SPRN. By contrast, expression of PRND was found to be sex-dimorphic, in agreement with its role in spermatogenesis. More importantly, our study revealed that PRND seems to be a key marker of foetal Leydig cells specifically in goats, suggesting a yet unknown role for its encoded protein Doppel during gonadal differentiation in nonrodent mammals.
authors.affiliation: Biologie du Développement et Reproduction INRA, UMR 1198 Jouy-en-Josas France; ALLICE Paris France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Allais-Bonnet
authors.affiliation: Génétique Animale et Biologie Intégrative INRA, UMR 1313 Jouy-en-Josas France.
authors.forename: Johan
authors.initials: J
authors.lastname: Castille
authors.affiliation: Biologie du Développement et Reproduction INRA, UMR 1198 Jouy-en-Josas France.
authors.forename: Maëlle
authors.initials: M
authors.lastname: Pannetier
authors.affiliation: Génétique Animale et Biologie Intégrative INRA, UMR 1313 Jouy-en-Josas France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Passet
authors.affiliation: Biologie du Développement et Reproduction INRA, UMR 1198 Jouy-en-Josas France.
authors.forename: Maëva
authors.initials: M
authors.lastname: Elzaïat
authors.affiliation: Biologie du Développement et Reproduction INRA, UMR 1198 Jouy-en-Josas France.
authors.forename: Marjolaine
authors.initials: M
authors.lastname: André
authors.affiliation: Biologie du Développement et Reproduction INRA, UMR 1198 Jouy-en-Josas France.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Montazer-Torbati
authors.affiliation: Génétique Animale et Biologie Intégrative INRA, UMR 1313 Jouy-en-Josas France.
authors.forename: Katayoun
authors.initials: K
authors.lastname: Moazami-Goudarzi
authors.affiliation: Génétique Animale et Biologie Intégrative INRA, UMR 1313 Jouy-en-Josas France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vilotte
authors.affiliation: Biologie du Développement et Reproduction INRA, UMR 1198 Jouy-en-Josas France.
authors.forename: Eric
authors.initials: E
authors.lastname: Pailhoux
keywords: Doppel; Shadoo; foetal Leydig; goat; mouse; prion