title: Perineural Invasion in the Absence of Malignancy: Report of Two Cases and Review of the Literature.
abstract: Perineural invasion is usually associated with invasion of the perineural space by malignant tumors. In this report, we describe 2 cases of perineural infiltration by benign-appearing epithelial cells in the skin. One case concerns a tumor-free reexcision specimen of a basal cell carcinoma and the other one an ulceration at the outer ear, consistent with acanthoma fissuratum, without a history of a previous excision. This finding was interpreted as a reactive process with dislocation of epithelium from the overlying epidermis into the perineural space.
authors.affiliation: Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland.
authors.forename: Katrin
authors.initials: K
authors.lastname: Pfaltz
authors.affiliation: Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland.
authors.forename: André
authors.initials: A
authors.lastname: Barghorn
authors.affiliation: Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland; Department of Dermatology, University Hospital, Zurich, Switzerland.
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
keywords: Epithelial neoplasms; Perineural invasion; Reexcision perineural invasion; Skin