title: Placental Transfer of Dengue Virus (DENV)-Specific Antibodies and Kinetics of DENV Infection-Enhancing Activity in Brazilian Infants.
abstract: Maternal-fetal transferred dengue virus (DENV)-specific antibodies have been implicated in the immunopathogenesis of dengue during infancy.
  
  
  
  A prospective birth cohort was established in a dengue-endemic area in the Northeast Region of Brazil. DENV-specific immunoglobulin G (IgG) and DENV-1-4 serotype-specific neutralizing antibody (NAb) levels were assessed in 376 paired maternal and umbilical cord blood samples. The kinetics of enhancing activity by maternally acquired DENV antibodies was determined in serum samples from children enrolled in the cohort.
  
  
  
  Mothers were mostly immune to DENV-3 alone (53.7%) or combined with DENV-4 (30.6%). Levels of DENV-specific IgG, DENV-3 NAbs, and DENV-4 NAbs were significantly higher in newborns than in their respective mothers. Mothers immune to a single serotype transferred greater levels of DENV-specific IgG (P = .02) and DENV-3 NAbs (P = .04) than mothers immune to multiple DENV serotypes. Maternally acquired DENV-3 NAbs disappeared in >90% of the children by the age of 4 months. The peak enhancing activity was detected by the age of 2 months (P < .0001) and rapidly declined by the age of 4 months (P = .0035).
  
  
  
  Unlike Asian infants, the enhancing activity of DENV infection by maternally transferred DENV antibodies occurs at earlier ages in Brazilian children. These findings might explain the low occurrence of severe dengue among infants in our setting.
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation.
authors.forename: Priscila M S
authors.initials: PM
authors.lastname: Castanha
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation Instituto de Medicina Integral Prof Fernando Figueira, Recife.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Braga
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation.
authors.forename: Marli T
authors.initials: MT
authors.lastname: Cordeiro
authors.affiliation: Instituto de Medicina Integral Prof Fernando Figueira, Recife.
authors.forename: Ariani I
authors.initials: AI
authors.lastname: Souza
authors.affiliation: Instituto de Medicina Integral Prof Fernando Figueira, Recife.
authors.forename: Claudeir D
authors.initials: CD
authors.lastname: Silva
authors.affiliation: Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Brazil.
authors.forename: Celina M T
authors.initials: CM
authors.lastname: Martelli
authors.affiliation: Department of Epidemiology, University of Pittsburgh Graduate School of Public Health.
authors.forename: Willem G
authors.initials: WG
authors.lastname: van Panhuis
authors.affiliation: Center for Vaccine Research Department of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania.
authors.forename: Eduardo J M
authors.initials: EJ
authors.lastname: Nascimento
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation Center for Vaccine Research Department of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania.
authors.forename: Ernesto T A
authors.initials: ET
authors.lastname: Marques
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D019138:Antibodies, Blocking / Q000097:blood*; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D019067:Antibody-Dependent Enhancement; D001938:Brazil; D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D019138:Antibodies, Blocking; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007074:Immunoglobulin G
keywords: IgG; antibody dependent enhancement; dengue; newborn; placental transfer