title: Statins and Aspirin use in HIV-infected people: gap between European AIDS Clinical Society guidelines and clinical practice: the results from HIV-HY study.
abstract: OBJECTIVE
  To investigate the use of statins and acetylsalicylic acid (ASA) in HIV people in clinical practice.
  
  
  METHODS
  A multicenter, nationwide, prospective cohort study, including 1182 consecutive HIV patients was conducted.
  
  
  METHODS
  Statin and ASA prescription was evaluated in primary and secondary cardiovascular disease prevention, according to the European AIDS Clinical Society (EACS) guidelines.
  
  
  RESULTS
  Followed-up patients (998) were mostly males (70.9 %) with a mean age at enrolment of 46.5 years (SD 9.5). The mean time of follow-up was 3.3 years (SD 0.8). At the last follow-up visit, statins would have been recommended for 31.2 % and ASA for 16 % by EACS guidelines. Conversely, only 15.6 and 7.6 % of patients were on statin and ASA treatment, respectively; only 50.3 % of patients treated with statins achieved recommended low-density lipoprotein cholesterol (LDL-c) levels. At the last follow-up visit, agreement between statin therapy and EACS recommendation was 0.58 (95 % CI 0.52-0.63). The corresponding figure for ASA therapy was 0.50 (95 % CI 0.42-0.58), whereas the agreement for ASA therapy in secondary prevention was 0.59 (95 % CI 0.50-0.68).
  
  
  CONCLUSIONS
  The prescription of statins and ASA in HIV-infected patients remains largely suboptimal, as only about 50 % of patients requiring statins and ASA are properly treated. Higher attention on this relevant issue and further investigation are warranted in this at risk population.
authors.affiliation: Clinica di Malattie Infettive, Azienda Ospedaliero-Universitaria di Perugia, Piazzale Menghini 1, 06129, Perugia, Italy. giuseppedesocio@yahoo.it.
authors.forename: Giuseppe Vittorio
authors.initials: GV
authors.lastname: De Socio
authors.affiliation: Department of Infectious Diseases, Luigi Sacco Hospital, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Ricci
authors.affiliation: Department of Infectious Diseases, Pescara Hospital, Pescara, Italy.
authors.forename: Giustino
authors.initials: G
authors.lastname: Parruti
authors.affiliation: Infectious Diseases Clinic, University of Bologna, Bologna, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Calza
authors.affiliation: Unit of Infectious Diseases, University of Bari, Bari, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Maggi
authors.affiliation: Unit of Infectious Diseases, Garibaldi Hospital, University of Catania, Catania, Italy.
authors.forename: Benedetto Maurizio
authors.initials: BM
authors.lastname: Celesia
authors.affiliation: Department of Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Orofino
authors.affiliation: Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
authors.forename: Giordano
authors.initials: G
authors.lastname: Madeddu
authors.affiliation: Department of Infectious Diseases, Careggi Hospital, Florence, Italy.
authors.forename: Canio
authors.initials: C
authors.lastname: Martinelli
authors.affiliation: Unit of Infectious Diseases, Busto Arsizio Hospital, Busto Arsizio, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Menzaghi
authors.affiliation: Infectious Diseases, Hospital University San Martino Genoa, Genoa, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Taramasso
authors.affiliation: Department of Infectious Diseases, Galliera Hospital, Genoa, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Penco
authors.affiliation: Department of Infectious Diseases, Luigi Sacco Hospital, Milan, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Carenzi
authors.affiliation: Unit of Infectious Diseases, University of Milan, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Franzetti
authors.affiliation: Unit of Infectious Diseases, Manzoni Hospital, Lecco, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonfanti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D005260:Female; D019983:Guideline Adherence / Q000706:statistics & numerical data; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000821:virology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007558:Italy; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D055502:Secondary Prevention / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D001241:Aspirin
keywords: Antiretroviral therapy; Aspirin; Atherosclerosis; Cardiovascular disease; Cardiovascular prevention; Clinical; Framingham; HIV; Statin