title: Oxcarbazepine-induced liver injury after sensitization by valproic acid: a case report.
abstract: OBJECTIVE
  The aim of the present case report is to describe a potential interaction between valproic acid and oxcarbazepine that resulted in hepatic injury.
  
  
  METHODS
  We report the case of a 46-year-old man with schizoaffective disorder who was cross-titrated from valproic acid to oxcarbazepine because of liver injury.
  
  
  RESULTS
  Initiation of oxcarbazepine four days after stopping valproic acid produced a significant elevation in liver enzymes that normalized with oxcarbazepine discontinuation and did not reappear with its reintroduction five days later.
  
  
  CONCLUSIONS
  Our findings suggest that a longer washout period or another agent should be considered when transitioning from valproic acid to oxcarbazepine.
authors.affiliation: Department of Psychiatry, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
authors.forename: Alanna
authors.initials: A
authors.lastname: Chait Mermelstein
authors.affiliation: Department of Medicine, Mount Sinai Beth Israel/Icahn School of Medicine, New York, NY, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Mermelstein
authors.affiliation: Department of Psychiatry, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
authors.forename: Tarek
authors.initials: T
authors.lastname: Adam
authors.affiliation: Department of Psychiatry, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Brody
authors.affiliation: Department of Psychiatry, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Dubin
keywords: liver injury; oxcarbazepine; transaminitis; valproic acid