title: Evaluation of tolerance and toxicity of high-dose-rate brachytherapy boost combined with interstitial hyperthermia for prostate cancer.
abstract: Purpose The aim of this retrospective study was to evaluate the tolerance and early as well as late toxicity of high dose rate brachytherapy (HDRBT) boost combined with interstitial hyperthermia (IHT) in patients treated for prostate cancer. Material and methods Between January 2011 and June 2013 76 patients diagnosed with prostate cancer received treatment consisting of external beam radiotherapy (EBRT), followed by a HDRBT boost combined with IHT. IHT was performed before each brachytherapy fraction. Results The median follow-up time was 26.3 months (range 7-43 months). Early genitourinary (GU) grade 1 and 2 toxicities were common, but only two patients (2.6%) experienced acute urinary retention requiring temporary catheterisation (grade 2 toxicity). No grade 3 or 4 genitourinary or gastrointestinal toxicities were observed. In the group analysed, 59 of 76 patients had follow-up times longer than 18 months. The incidence of grade 2 late toxicity in the group studied did not exceed 23.7%. There were no late grade 2 or higher complications from the gastrointestinal tract. Conclusions The tolerance of HDRBT boost combined with IHT is good. The profile and the percentage of early and late complications are acceptable.
authors.affiliation: a Amethyst Radiotherapy Centre, Ludwik Rydygier Memorial Hospital , Kraków , Poland ;|b Department of Radiotherapy , Maria Skłodowska Curie Memorial Centre of Oncology , Kraków Division , Poland ;
authors.forename: Andrzej Marek
authors.initials: AM
authors.lastname: Kukiełka
authors.affiliation: a Amethyst Radiotherapy Centre, Ludwik Rydygier Memorial Hospital , Kraków , Poland ;
authors.forename: Marcin
authors.initials: M
authors.lastname: Hetnał
authors.affiliation: a Amethyst Radiotherapy Centre, Ludwik Rydygier Memorial Hospital , Kraków , Poland ;|c Gynecology and Oncology Clinic , Collegium Medicum Jagiellonian University , Kraków , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bereza
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects; D017115:Catheter Ablation / Q000009:adverse effects; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D012189:Retrospective Studies
keywords: HDR brachytherapy; hyperthermia; microwave; prostate cancer; radiofrequency