title: Disease Burden Due to Herpes Zoster among Population Aged ≥50 Years Old in China: A Community Based Retrospective Survey.
abstract: OBJECTIVE
  To understand the disease burden due to Herpes Zoster (HZ) among people aged ≥50 years old in China and provide baseline data for future similar studies, and provide evidence for development of herpes zoster vaccination strategy.
  
  
  METHODS
  Retrospective cohort study was conducted in 4 townships and one community. A questionnaire was used to collect information on incidence and cost of HZ among people aged ≥ 50 years old.
  
  
  RESULTS
  The cumulative incidence rate was 22.6/1,000 among people aged ≥ 50 years old. The average annual incidence rate of HZ was 3.43/1,000 among people aged ≥ 50 years old in 2010-2012. Cumulative incidence and average annual incidence rate increased with age: the cumulative incidence of HZ among people aged ≥ 80 years old was 3.34 times of that among 50-years old (52.3/1000 vs 15.7/1,000); average annual incidence rate rises from 2.66/1,000 among 50-years old to 8.55/1,000 among 80-year old. Cumulative incidence and average annual incidence rate for females were higher than that for males (cumulative incidence, 26.5/1000 vs 18.7/1,000; annual incidence rate, 3.95/1000 vs 2.89/1,000). Cumulative incidence and average annual incidence rate in urban were higher than in rural (cumulative incidence, 39.5/1000 vs 17.2/1,000; annual incidence rate, 7.65/1000 vs 2.06/1,000). The hospitalization rate of HZ was 4.53%. And with the increase of age, the rate has an increasing trend. HZ costs 945,709.5 RMB in total, corresponding to 840.6 RMB per patient with a median cost of 385 RMB (interquartile range 171.7-795.6). Factors associated with cost included the first onset year, area, whether hospitalized and whether sequelae left.
  
  
  CONCLUSIONS
  Incidence rate, complications, hospitalization rate and average cost of HZ increase with age. We recommend that the HZ vaccinations should target people aged ≥50 years old if Zoster vaccine is licensed in China.
authors.affiliation: National immunization program, Chinese center for disease control and prevention, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: National immunization program, Chinese center for disease control and prevention, Beijing, China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: An
authors.affiliation: National immunization program, Chinese center for disease control and prevention, Beijing, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yin
authors.affiliation: National immunization program, Chinese center for disease control and prevention, Beijing, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Immunization program department, Shanghai municipal center for disease control and prevention, Shanghai, China.
authors.forename: Zhuoying
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Immunization program department, Danyang county center for disease control and prevention, Zhenjiang, Jiangsu, China.
authors.forename: Jianfang
authors.initials: J
authors.lastname: Xu
authors.affiliation: Immunization program department, Heilongjiang provincial center for disease control and prevention, Haerbin, Heilongjiang, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Immunization program department, Jiangxi provincial center for disease control and prevention, Nanchang, Jiangxi, China.
authors.forename: Qiufeng
authors.initials: Q
authors.lastname: Tu
authors.affiliation: Immunization program department, Hebei provincial center for disease control and prevention, Shijiazhuang, Hebei, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.affiliation: National immunization program, Chinese center for disease control and prevention, Beijing, China.
authors.forename: Huaqing
authors.initials: H
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D006562:Herpes Zoster / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012424:Rural Population; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014505:Urban Population