title: FDG PET/CT in bone sarcoidosis.
abstract: BACKGROUND
  Bone sarcoidosis is rare manifestation of disease usually accompanied with pulmonary involvement. Until today, exact prevalence of bone sarcoidosis is not known, since reported prevalence varies widely depending on the studied population and the used diagnostic techniques.
  
  
  OBJECTIVE
  To determine the prevalence of bone involvement and distribution pattern in active chronic sarcoidosis by using FDG PET/CT.
  
  
  METHODS
  Between January 2010 and December 2011, 98 patients with chronic sarcoidosis and presence of prolonged symptoms or other findings suggestive of active disease were referred to FDG PET/CT examination. Active disease was found in 82 patients, and they all were screened for presence of bone sarcoidosis on FDG PET/CT. All patients also underwent MDCT and assessment of serum ACE level.
  
  
  RESULTS
  Bone sarcoidosis was present in 18/82 patients with active sarcoidosis. FDG uptake in bones was focal in 8 (44.4%), diffuse in 6 (33.3%) and both diffuse and focal in 4 (22.2%) patients. CT indicated bone abnormalities only in 5% patients. Osseous involvement was present in: pelvis (61.1%), vertebrae (44.4%), ribs (27.8%) and bone marrow (16.7%). Some patients had two or more locations of disease. Follow-up FDG PET/CT showed normal findings in two patients, same localization of active disease in four patients and progression of disease in one.
  
  
  CONCLUSIONS
  In patients with active chronic sarcoidosis 22% of patients had osseous abnormalities on FDG PET/CT that mostly were not detected on CT.
authors.affiliation: PhD. drisidora.grozdic@yahoo.com.
authors.forename: Isidora
authors.initials: I
authors.lastname: Grozdic Milojevic
authors.forename: Dragana
authors.initials: D
authors.lastname: Sobic-Saranovic
authors.forename: Jelica
authors.initials: J
authors.lastname: Videnovic-Ivanov
authors.forename: Djordjije
authors.initials: D
authors.lastname: Saranovic
authors.forename: Strahinja
authors.initials: S
authors.lastname: Odalovic
authors.forename: Vera
authors.initials: V
authors.lastname: Artiko
mesh_terms: D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D015995:Prevalence; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000453:epidemiology
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Chronic sarcoidosis; FDG PET/CT; Osseous sarcoidosis