title: Diagnosis and Management of Malignant Salivary Gland Tumors of the Parotid Gland.
abstract: Malignant parotid tumors are heterogeneous and diverse. Accurate diagnosis requires a pathologist familiar with the various histologic subtypes, immunohistochemistry stains, and common translocations. Clinical course varies according to tumor subtype, ranging from indolent, slow-growing adenoid cystic carcinoma to rapidly progressive, possibly fatal, salivary ductal carcinoma. Histologic grade is important in prognosis and therapy. Surgery remains the mainstay of treatment when negative margins can be achieved. Radiation improves locoregional control of tumors with high-risk features. Chemotherapy for parotid tumors can be disappointing. Studies of new targeted therapies have not offered significant benefits.
authors.affiliation: Department of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Aaron G
authors.initials: AG
authors.lastname: Lewis
authors.affiliation: Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Tommy
authors.initials: T
authors.lastname: Tong
authors.affiliation: Division of Head and Neck Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address: emaghami@coh.org.
authors.forename: Ellie
authors.initials: E
authors.lastname: Maghami
mesh_terms: D044963:Biopsy, Fine-Needle; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000628:therapy; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology* / Q000628:therapy; D019468:Disease Management; D004358:Drug Therapy; D006801:Humans; D007150:Immunohistochemistry; D058990:Molecular Targeted Therapy; D010306:Parotid Gland / Q000473:pathology*; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D011379:Prognosis; D011878:Radiotherapy; D019651:Plastic Surgery Procedures
keywords: Chemotherapy for parotid tumors; Genetic translocations of parotid tumors; Malignant salivary cancers; Molecular diagnostics; Molecular targeted therapies; Parotid cancer; Radiation therapy for parotid cancers; Surgery for parotid salivary cancer