title: Prosthetic joint infections secondary to rapidly growing mycobacteria: Two case reports and a review of the literature.
abstract: Rapidly growing mycobacteria (RGM) are a rare but treatable cause of prosthetic joint infections. This study reports on two patients comprising three prosthetic joint infections caused by RGM successfully treated at the institution. With removal of the infected prosthetic joint and judicious use of prolonged courses of antibiotics, patients with prosthetic joint infections secondary to RGM can both be cured and retain function of the affected joint. In addition, this study identified 40 additional cases reported during an extensive review of the literature and provide a summary of these cases. These infections can present within days of arthroplasty or can develop only decades after the index surgery. The clinical presentations often mimic those of more routine bacterial prosthetic joint infections.
authors.affiliation: a Division of Infectious Diseases, Department of Medicine , Weill Cornell Medical Center , New York , NY , USA ;|b Hospital for Special Surgery , New York , NY , USA ;
authors.forename: Michael W
authors.initials: MW
authors.lastname: Henry
authors.affiliation: a Division of Infectious Diseases, Department of Medicine , Weill Cornell Medical Center , New York , NY , USA ;|b Hospital for Special Surgery , New York , NY , USA ;
authors.forename: Andy O
authors.initials: AO
authors.lastname: Miller
authors.affiliation: c Department of Orthopedics , Hospital for Special Surgery , New York , NY , USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kahn
authors.affiliation: c Department of Orthopedics , Hospital for Special Surgery , New York , NY , USA.
authors.forename: Russel E
authors.initials: RE
authors.lastname: Windsor
authors.affiliation: a Division of Infectious Diseases, Department of Medicine , Weill Cornell Medical Center , New York , NY , USA ;|b Hospital for Special Surgery , New York , NY , USA ;
authors.forename: Barry D
authors.initials: BD
authors.lastname: Brause
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001178:Arthroplasty; D005260:Female; D006622:Hip Prosthesis / Q000382:microbiology; D006801:Humans; D007595:Joint Prosthesis / Q000382:microbiology*; D007719:Knee Joint / Q000601:surgery; D007720:Knee Prosthesis / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000382:microbiology* / Q000628:therapy*; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification*; D010384:Pelvic Bones / Q000601:surgery; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Rapidly growing mycobacteria; arthroplasty; prosthetic joint infections