title: Primary Systemic Amyloidosis with Unusual Dermatological Manifestations: A Rare Case Report.
abstract: Amyloidosis is a group of heterogeneous diseases characterized by pathological deposition of proteinaceous substance extracellularly in various tissues. The clinical presentation depends on the site of amyloid deposition, with predominant involvement of mesenchymal elements and cutaneous findings in 30-40% of patients in case of primary systemic amyloidosis. We present a case of idiopathic primary systemic amyloidosis presenting with an unusual finding of nodulo-ulcerative lesion over tongue along with multiple skin-colored nodules, mimicking squamous cell carcinoma of tongue with secondary cutaneous metastasis, as well as lacking the classical presentation of purpura, macroglossia, waxy papules, and plaques.
authors.affiliation: Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Vyas
authors.affiliation: Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
authors.forename: Manjaree
authors.initials: M
authors.lastname: Morgaonkar
authors.affiliation: Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
authors.forename: Savera
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Jain
keywords: Amyloidosis; nodules; purpura