title: Long-Term Supplementation with Chromium Malate Improves Short Chain Fatty Acid Content in Sprague-Dawley Rats.
abstract: Our previous study showed that chromium malate improved the composition of intestinal flora, glycometabolism, glycometabolism-related enzymes, and lipid metabolism in type 2 diabetes mellitus (T2DM) rats. The present study was designed to evaluate the effect of chromium malate with long-term supplementation on short chain fatty acid (SCFA) content in Sprague-Dawley rats. The samples were analyzed by gas chromatography with high linearity (R2≥ 0.9995), low quantification limit (0.011-0.070 mM), and satisfactory recoveries. The method was simple and environmentally friendly. The acetic content in cecum of 3-month control group was significantly higher than that of 1-year control group. When compared with 1-year control group, chromium malate (at a dose of 20.0 μg Cr/kg bw) could significantly increase acetic, propionic, i-butyric butyric, butyric, i-valeric, valeric, and n-caproic levels. The acetic, propionic, i-butyric, valeric, and n-caproic contents of 1-year chromium malate group (at a dose of 20.0 μg Cr/kg bw) had a significant improvement when compared with 1-year chromium picolinate group. Acetic, propionic, and butyric contained approximately 91.65 % of the total SCFAs in 1-year group. The results indicated that the improvement of chromium malate on short chain fatty acid content change was better than that of chromium picolinate.
authors.affiliation: School of Pharmacy, Jiangsu University, Xuefu Rd. 301, Zhenjiang, 212013, Jiangsu, China.
authors.forename: Huiyu
authors.initials: H
authors.lastname: Wu
authors.affiliation: School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Feng
authors.affiliation: School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Mao
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
authors.forename: Songmei
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Jiangsu University, Xuefu Rd. 301, Zhenjiang, 212013, Jiangsu, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Zou
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China. yangliuqing@ujs.edu.cn.
authors.forename: Liuqing
authors.initials: L
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Jiangsu University, Xuefu Rd. 301, Zhenjiang, 212013, Jiangsu, China. wangliang_06@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D002857:Chromium / Q000494:pharmacology*; D019587:Dietary Supplements; D005227:Fatty Acids / Q000378:metabolism*; D008293:Malates / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D005227:Fatty Acids; D008293:Malates; D002857:Chromium
keywords: Cecum content; Chromium malate; Gas chromatography; Short chain fatty acids (SCFAs)