title: Emergence of KPC-producing Klebsiella pneumoniae hypervirulent clone of capsular serotype K1 that belongs to sequence type 11 in Mainland China.
abstract: KPC-2 has been rarely reported in hypervirulent Klebsiella pneumoniae strains. Here, we describe a KPC-2-producing K. pneumoniae hypervirulent clone of capsular serotype K1 belonging to sequence type 11. The presence of KPC carbapenemase in hypervirulent clone could mark an evolutionary step toward its establishment as major nosocomial pathogen.
authors.affiliation: Department of Bacteriology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong wai zheng jie No. 17, Nanchang, 330006, PR China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Wei
authors.affiliation: Department of Bacteriology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong wai zheng jie No. 17, Nanchang, 330006, PR China.
authors.forename: La-Gen
authors.initials: LG
authors.lastname: Wan
authors.affiliation: Department of Hospital Infection Control, First Affiliated Hospital of Nanchang University, Nanchang University, Yong wai zheng jie No. 17, Nanchang, 330006, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Deng
authors.affiliation: Department of Bacteriology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong wai zheng jie No. 17, Nanchang, 330006, PR China. Electronic address: ly13767160474@sina.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis*; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D011135:Polysaccharides, Bacterial / Q000032:analysis*; D065288:Serogroup; D014774:Virulence; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000942:Antigens, Bacterial; D011135:Polysaccharides, Bacterial; C036962:capsular polysaccharide K1; D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae
keywords: Hypervirulent serotype; KPC; Klebsiella; MLST; Plasmid