title: Geraniin ameliorates cisplatin-induced nephrotoxicity in mice.
abstract: Geraniin, an active compound isolated from Geranium sibiricum, has been reported to have antioxidant and anti-inflammatory activities. The aim of this study was to investigate the protective effects of geraniin against cisplatin (CP)-induced kidney injury in mice. Geraniin was administrated for three consecutive days following CP (20 mg/kg) injection. The results showed that geraniin inhibited CP-induced kidney histopathologic changes, MDA, inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production in kidney tissues. Geraniin also inhibited CP-induced blood urea nitrogen (BUN) and creatinine production. Meanwhile, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) decreased by CP were reversed by the treatment of geraniin. In addition, geraniin significantly inhibited CP-induced NF-κB activation in kidney tissues. Treatment of geraniin dosedependently upregulated the expression of Nrf2 and HO-1. The anticancer effects of CP were not affected by the treatment of geraniin. In conclusion, these results indicated that geraniin protected against CP-induced nephrotoxicity by inhibiting oxidative stress and inflammatory response.
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China ;
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China ;
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China ;
authors.forename: Pengcheng
authors.initials: P
authors.lastname: He
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China ;
authors.forename: Jiyan
authors.initials: J
authors.lastname: Chen
authors.affiliation: b Department of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
authors.forename: Shuangxin
authors.initials: S
authors.lastname: Liu
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China ;
authors.forename: Ning
authors.initials: N
authors.lastname: Tan
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D004195:Disease Models, Animal; D005960:Glucosides / Q000008:administration & dosage / Q000627:therapeutic use*; D047348:Hydrolyzable Tannins / Q000008:administration & dosage / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000378:metabolism*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000473:pathology
chemical_list: D005960:Glucosides; D047348:Hydrolyzable Tannins; D016328:NF-kappa B; C024603:Geraniin; D002945:Cisplatin
keywords: Geraniin; NF-κB; cisplatin; nephrotoxicity