title: Delivery of tanshinone IIA and α-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy.
abstract: A new anti-cancer drug delivery system, based on gold nanoparticles, has been designed for hydrophobic active compounds. The system is a conjugate of gold/polyethyleneimine (AuNPs/PEI) nanoparticles and sulphated β-cyclodextrin (CD). Anionic cyclodextrin was attached to the positively charged AuNPs/PEI nanoparticles by ionic bonds. Tanshinone IIA and α-mangostin were extracted, purified and encapsulated into the AuNPs/PEI/CD nanoparticles. In vitro preliminary cell viability assays against prostate cancer cell lines PC-3 and DU145 showed that encapsulation resulted in increased cytotoxicity.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Shihong
authors.initials: S
authors.lastname: Qiu
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Granet
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Mbakidi
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Brégier
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Pouget
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Micallef
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Tan
authors.initials: T
authors.lastname: Sothea-Ouk
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: David Y
authors.initials: DY
authors.lastname: Leger
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Liagre
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Chaleix
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
mesh_terms: D045784:Abietanes / Q000008:administration & dosage*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D003505:Cyclodextrins / Q000737:chemistry; D053938:DNA Fragmentation / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D006046:Gold / Q000737:chemistry; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry; D011094:Polyethyleneimine / Q000008:administration & dosage / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D044004:Xanthones / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D003505:Cyclodextrins; D044004:Xanthones; C021751:tanshinone; D006046:Gold; D011094:Polyethyleneimine; C021053:mangostin
keywords: Gold nanoparticles; PEI; Prostate cancer cell lines; Tanshinone IIA; α-Mangostin