title: Investigating the Frequency of the ERCC1 Gene C8092A Polymorphism in Iranian Patients with Advanced Gastric Cancer Receiving Platinum-based Chemotherapy.
abstract: BACKGROUND
  Platinum compounds are the main drugs for treatment of advanced gastric cancer. Previous studies have shown that clinical outcome with platinum-based compounds depends on ERCC1 polymorphisms. The aim of this study was to investigate the frequency of a common polymorphism of ERCC1 gene (C8092A) in Iranian patients with advanced gastric cancer receiving platinum chemotherapy.
  
  
  METHODS
  Genetic analysis of the ERCC1 C8092A polymorphism was performed by the PCR - RFLP method using 50 paraffin-embedded tissue specimens.
  
  
  RESULTS
  Of the 50 cases, 32% of individuals showed CC genotype, 24% of them had CA genotype and 44% of patients had AA genotype.
  
  
  CONCLUSIONS
  Based on the results, using of platinum-based chemotherapy would be expected to be specifically beneficial in only 32% of patients.
authors.affiliation: Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran E-mail : golnaz_asaadi@yahoo.com.
authors.forename: Sharareh
authors.initials: S
authors.lastname: Mokmeli
authors.forename: Golnaz Asaadi
authors.initials: GA
authors.lastname: Tehrani
authors.forename: Reza Eghdam
authors.initials: RE
authors.lastname: Zamiri
authors.forename: Tayyeb
authors.initials: T
authors.lastname: Bahrami
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D017671:Platinum Compounds / Q000627:therapeutic use*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D017671:Platinum Compounds; C071447:ERCC1 protein, human; D004720:Endonucleases