title: Dendrimer-Templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation.
abstract: Ultrasmall and multifunctional nanoparticles are highly desirable for photothermal cancer therapy, but the synthesis of these nanoparticles remains a huge challenge. Here, we used a dendrimer as a template to synthesize ultrasmall photothermal agents and further modified them with multifunctional groups. Dendrimer-encapsulated nanoparticles (DENPs) including copper sulfide, platinum, and palladium nanoparticles possessed a sub-5 nm size and exhibited an excellent photothermal effect. DENPs were further modified with TAT or RGD peptides to facilitate their cellular uptake and targeting delivery to tumors. They were also decorated with fluorescent probes for real-time imaging and tracking of the particles' distribution. The in vivo study revealed RGD-modified DENPs efficiently reduced the tumor growth upon near-infrared irradiation. In all, our study provides a facile and flexible scaffold to prepare ultrasmall and multifunctional photothermal agents.
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University , Shanghai 200241, People's Republic of China.
authors.forename: Zhengjie
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University , Shanghai 200241, People's Republic of China.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University , Shanghai 200241, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University , Shanghai 200241, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University , Shanghai 200241, People's Republic of China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D008027:Light; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D009842:Oligopeptides / Q000737:chemistry; D061848:Optical Imaging / Q000379:methods; D010165:Palladium / Q000737:chemistry; D010316:Particle Size; D010446:Peptide Fragments / Q000737:chemistry; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use; D010789:Phototherapy / Q000379:methods*; D010984:Platinum / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D005456:Fluorescent Dyes; D009842:Oligopeptides; C104700:PAMAM Starburst; D010446:Peptide Fragments; D017319:Photosensitizing Agents; D010984:Platinum; D010165:Palladium; D003300:Copper; C047981:arginyl-glycyl-aspartic acid
keywords: cancer targeting; dendrimer; multifunctional; photothermal therapy; ultrasmall