title: Epidermal growth factor receptor (EGFR) mutations in small cell lung cancers: Two cases and a review of the literature.
abstract: Activating mutations in the epidermal growth factor receptor (EGFR) gene are exceedingly rare in small cell lung cancer (SCLC). We present two cases of SCLC harboring EGFR mutations, one in an 82 year-old male smoker with a combined SCLC and adenocarcinoma with a novel D855H point mutation in exon 21, and the second in a 68 year-old female never smoker with the L858R point mutation in exon 21. The cases, accompanied by a review of the literature, highlight the importance of integration of clinicopathologic considerations and adherence to recently promulgated Guideline recommendations for molecular testing in lung cancer.
authors.affiliation: University of Colorado, United States.
authors.forename: Bradford J
authors.initials: BJ
authors.lastname: Siegele
authors.affiliation: The Ohio State University, United States.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Shilo
authors.affiliation: The Ohio State University, United States.
authors.forename: Bo H
authors.initials: BH
authors.lastname: Chao
authors.affiliation: The Ohio State University, United States.
authors.forename: David P
authors.initials: DP
authors.lastname: Carbone
authors.affiliation: The Ohio State University, United States.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Zhao
authors.affiliation: University of Maryland Greenebaum Cancer Center, United States.
authors.forename: Olga
authors.initials: O
authors.lastname: Ioffe
authors.affiliation: University of Colorado, United States.
authors.forename: Wilbur A
authors.initials: WA
authors.lastname: Franklin
authors.affiliation: University of Maryland Greenebaum Cancer Center, United States.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Edelman
authors.affiliation: University of Colorado, United States. Electronic address: Dara.Aisner@ucdenver.edu.
authors.forename: Dara L
authors.initials: DL
authors.lastname: Aisner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003062:Codon; D003131:Combined Modality Therapy; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008297:Male; D009154:Mutation; D000072078:Positron Emission Tomography Computed Tomography; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D003062:Codon; D066246:ErbB Receptors
keywords: Adenocarcinoma; EGFR; Guideline; Molecular; Pathology; SCLC