title: Dream Recall Frequencies and Dream Content in Wilson's Disease with and without REM Sleep Behaviour Disorder: A Neurooneirologic Study.
abstract: Objective. Violent dream content and its acting out during rapid eye movement sleep are considered distinctive for rapid eye movement sleep behaviour disorder (RBD). This study reports first quantitative data on dreaming in a cohort of patients with treated Wilson's disease (WD) and in patients with WD with RBD. Methods. Retrospective questionnaires on different dimensions of dreaming and a prospective two-week home dream diary with self-rating of emotions and blinded, categorical rating of content by an external judge. Results. WD patients showed a significantly lower dream word count and very few other differences in dream characteristics compared to age- and sex-matched healthy controls. Compared to WD patients without RBD, patients with WD and RBD reported significantly higher nightmare frequencies and more dreams with violent or aggressive content retrospectively; their prospectively collected dream reports contained significantly more negative emotions and aggression. Conclusions. The reduction in dream length might reflect specific cognitive deficits in WD. The lack of differences regarding dream content might be explained by the established successful WD treatment. RBD in WD had a strong impact on dreaming. In accordance with the current definition of RBD, violent, aggressive dream content seems to be a characteristic of RBD also in WD.
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil; Sleep Laboratory, Pulmonary Division, InCor, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar 44, 05403-000 Cerqueira Cesar, SP, Brazil.
authors.forename: Gotthard G
authors.identifier: 0000-0003-1325-8345
authors.initials: GG
authors.lastname: Tribl
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Mateus C
authors.initials: MC
authors.lastname: Trindade
authors.affiliation: Sleep Laboratory, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J 5, 68159 Mannheim, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Schredl
authors.affiliation: EEG and Sleep Laboratory, Department of Neurosciences, Santa Maria University Hospital, Avenida Prof. Egas Moniz, 1649-035 Lisbon, Portugal; Electroencephalography and Clinical Neurophysiology Center (CENC), Rua Conde das Antas n°5, 1070-068 Lisbon, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Pires
authors.affiliation: Department of Biostatistics, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J 5, 68159 Mannheim, Germany.
authors.forename: Iris
authors.initials: I
authors.lastname: Reinhard
authors.affiliation: Sleep Laboratory, Pulmonary Division, InCor, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar 44, 05403-000 Cerqueira Cesar, SP, Brazil.
authors.forename: Thais
authors.initials: T
authors.lastname: Bittencourt
authors.affiliation: Sleep Laboratory, Pulmonary Division, InCor, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar 44, 05403-000 Cerqueira Cesar, SP, Brazil.
authors.forename: Geraldo
authors.initials: G
authors.lastname: Lorenzi-Filho
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Rosana Cardoso
authors.initials: RC
authors.lastname: Alves
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Daniel Ciampi
authors.initials: DC
authors.lastname: de Andrade
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Erich T
authors.initials: ET
authors.lastname: Fonoff
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Edson
authors.initials: E
authors.lastname: Bor-Seng-Shu
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Alexandre A
authors.initials: AA
authors.lastname: Machado
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Manoel J
authors.initials: MJ
authors.lastname: Teixeira
authors.affiliation: Division of Neurology and Neurosurgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Avenida Dr. Eneas de Carvalho Aguiar, 255, 5° Andar, Sala 5084, 05403-900 Pinheiros, SP, Brazil.
authors.forename: Egberto R
authors.initials: ER
authors.lastname: Barbosa
mesh_terms: D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D003072:Cognition Disorders; D004325:Dreams / Q000502:physiology / Q000523:psychology*; D004644:Emotions; D005260:Female; D006527:Hepatolenticular Degeneration / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology; D017286:Polysomnography; D011446:Prospective Studies; D020187:REM Sleep Behavior Disorder; D012189:Retrospective Studies; D057566:Self Report; D012895:Sleep, REM / Q000502:physiology; D011795:Surveys and Questionnaires