title: Commandeering the Ribosome: Lessons Learned from Dicistroviruses about Translation.
abstract: To replicate, all viruses depend entirely on the enslavement of host cell ribosomes for their own advantage. To this end, viruses have evolved a multitude of translational strategies to usurp the ribosome. RNA-based structures known as internal ribosome entry sites (IRESs) are among the most notable mechanisms employed by viruses to seize host ribosomes. In this article, we spotlight the intergenic region IRES from the Dicistroviridae family of viruses and its importance as a model for IRES-dependent translation and in understanding fundamental properties of translation.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Craig H
authors.initials: CH
authors.lastname: Kerr
authors.affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada ej@mail.ubc.ca.
authors.forename: Eric
authors.initials: E
authors.lastname: Jan
mesh_terms: D000818:Animals; D056629:Dicistroviridae / Q000235:genetics* / Q000502:physiology*; D016679:Genome, Viral; D054884:Host-Pathogen Interactions; D000067556:Internal Ribosome Entry Sites; D008958:Models, Molecular; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000235:genetics; D012270:Ribosomes / Q000235:genetics* / Q000378:metabolism / Q000821:virology
chemical_list: D000067556:Internal Ribosome Entry Sites; D012367:RNA, Viral