title: How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability.
abstract: Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pHmax above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.
authors.affiliation: Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA. nrh@umich.edu.
authors.forename: G
authors.initials: G
authors.lastname: Kuminek
authors.forename: N
authors.initials: N
authors.lastname: Rodríguez-Hornedo
authors.forename: S
authors.initials: S
authors.lastname: Siedler
authors.forename: H V A
authors.initials: HV
authors.lastname: Rocha
authors.forename: S L
authors.initials: SL
authors.lastname: Cuffini
authors.forename: S G
authors.initials: SG
authors.lastname: Cardoso
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008298:Maleates / Q000737:chemistry*; D019829:Nevirapine / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry*; D012439:Saccharin / Q000737:chemistry*; D020156:Salicylic Acid / Q000737:chemistry*; D012995:Solubility
chemical_list: D019380:Anti-HIV Agents; D008298:Maleates; D018894:Reverse Transcriptase Inhibitors; C030272:maleic acid; D019829:Nevirapine; D012439:Saccharin; D020156:Salicylic Acid