title: Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles.
abstract: Utilizing the biological activities of compounds by encapsulating natural components in stable nanoparticles is an important strategy for a variety of biomedical and healthcare applications. In this study, quercetin-loaded silica nanoparticles were synthesized using an oil-in-water microemulsion method, which is a suitable system for producing functional nanoparticles of controlled size and shape. The resulting quercetin-loaded silica nanoparticles were spherical, highly monodispersed, and stable in an aqueous system. Superoxide radical scavenging effects were found for the quercetin-loaded silica nanoparticles as well as free quercetin. The quercetin-loaded silica nanoparticles showed cell viability comparable to that of the controls. The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles. These results suggest that the antioxidative and antiinflammatory activities of quercetin are maintained after encapsulation in silica. Silica nanoparticles can be used for the effective and stable incorporation of biologically active natural components into composite biomaterials.
authors.affiliation: Division of Nano & Bio Technology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea; Department of Advanced Organic Materials Science and Engineering, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Ga Hyun
authors.initials: GH
authors.lastname: Lee
authors.affiliation: Division of Nano & Bio Technology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.
authors.forename: Sung June
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Division of Nano & Bio Technology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Jeong
authors.affiliation: Division of Nano & Bio Technology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.
authors.forename: Hyun-Chul
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Department of Bio-fibers and materials Science, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Ga Young
authors.initials: GY
authors.lastname: Park
authors.affiliation: Division of Nano & Bio Technology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea. Electronic address: sklee@dgist.ac.kr.
authors.forename: Se Geun
authors.initials: SG
authors.lastname: Lee
authors.affiliation: Department of Advanced Organic Materials Science and Engineering, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Bio-fibers and materials Science, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address: jinhchoi@knu.ac.kr.
authors.forename: Jin Hyun
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004339:Drug Compounding; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004337:Drug Carriers; D053583:Interleukin-1beta; D015850:Interleukin-6; D011794:Quercetin; D012822:Silicon Dioxide; D013481:Superoxides; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C587672:IL1B protein, mouse; C577686:interleukin-6, mouse
keywords: Antiinflammatory; Antioxidative; Microemulsion; Nanoparticles; Quercetin; Silica