title: Emerging Role of PML Nuclear Bodies in Innate Immune Signaling.
abstract: Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PML, hDaxx, Sp100, or ATRX protein, that are able to act as cellular restriction factors. Recent studies now reveal an emerging role of PML-NBs as coregulatory structures of both type I and type II interferon responses. This emphasizes that targeting of PML-NBs by viral regulatory proteins has evolved as a strategy to compromise intrinsic antiviral defense and innate immune responses.
authors.affiliation: Institute for Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Myriam
authors.initials: M
authors.lastname: Scherer
authors.affiliation: Institute for Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany thomas.stamminger@viro.med.uni-erlangen.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Stamminger
mesh_terms: D000818:Animals; D003587:Cytomegalovirus / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D006801:Humans; D007113:Immunity, Innate; D045586:Intranuclear Inclusion Bodies / Q000378:metabolism*; D051379:Mice; D000071156:Promyelocytic Leukemia Protein / Q000378:metabolism; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology*; D018406:Virus Physiological Phenomena; D014779:Virus Replication
chemical_list: D000071156:Promyelocytic Leukemia Protein; D014764:Viral Proteins