title: Knee pain during activities of daily living and its relationship with physical activity in patients with early and severe knee osteoarthritis.
abstract: This study aimed to investigate whether knee pain during various activities of daily living (ADLs) is associated with physical activity in patients with early and severe knee osteoarthritis (OA). We hypothesized that the painful ADLs associated with decreased physical activity differ according to disease severity. This cross-sectional study enrolled 270 patients with medial knee OA, assigned to either the early (Kellgren Lawrence [K/L] grade 1-2) or the severe group (K/L grade 3-4). Physical activity was assessed using a pedometer. Knee pain during six ADLs (waking up in the morning, walking on a flat surface, ascending stairs, etc.) was evaluated using a questionnaire. We performed multiple regression and quantile regression analysis to investigate whether knee pain during each ADL was associated with physical activity. In the early group, the more knee pain they experienced while ascending stairs, the lower their physical activity was (75th regression coefficient = -1033.70, P = 0.018). In the severe group, the more knee pain they experienced while walking on a flat surface or bending to the floor or standing up, the lower their physical activity was (unstandardized coefficients = -1850.87, P = 0.026; unstandardized coefficients = -2640.35, P = 0.010). Knee pain while ascending stairs and while walking on a flat surface or bending to the floor or standing up was a probable limiting factor for physical activity in early and severe knee OA, respectively. These findings suggested that a reduction in task-specific knee pain according to disease severity could improve physical activity levels.
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. nafukutani@gmail.com.
authors.forename: Naoto
authors.initials: N
authors.lastname: Fukutani
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.|Japan Society for the Promotion of Science, 5-3-1 Koujimachi, Chiyoda-ku, Tokyo, 102-0083, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Iijima
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Nozomi Orthopaedic Clinic, 1182-1 Sukezane, Saijo-cho, Higashihiroshima-shi, Hiroshima, 739-0021, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Nozomi Orthopaedic Clinic, 1182-1 Sukezane, Saijo-cho, Higashihiroshima-shi, Hiroshima, 739-0021, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hiraoka
authors.affiliation: Nozomi Orthopaedic Clinic, 1182-1 Sukezane, Saijo-cho, Higashihiroshima-shi, Hiroshima, 739-0021, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyanobu
authors.affiliation: Nozomi Orthopaedic Clinic Hiroshima, 3-6-30 Toshimatsu, Saeki-ku, Hiroshima-shi, Hiroshima, 731-5106, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Jinnouchi
authors.affiliation: Nozomi Orthopaedic Clinic, 1182-1 Sukezane, Saijo-cho, Higashihiroshima-shi, Hiroshima, 739-0021, Japan.|Nozomi Orthopaedic Clinic Hiroshima, 3-6-30 Toshimatsu, Saeki-ku, Hiroshima-shi, Hiroshima, 731-5106, Japan.
authors.forename: Eishi
authors.initials: E
authors.lastname: Kaneda
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Tsuboyama
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Matsuda
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000503:physiopathology*; D010146:Pain / Q000175:diagnosis / Q000503:physiopathology*; D010147:Pain Measurement; D011859:Radiography; D012720:Severity of Illness Index
keywords: Activities of daily living (ADLs); Early; Knee osteoarthritis; Knee pain; Physical activity; Severe