title: Increased Soluble CD155 in the Serum of Cancer Patients.
abstract: Emerging evidence suggests that DNAM-1 (CD226) play an important role in the recognition of tumor cells and their lysis by cytotoxic T lymphocytes (CTL) and NK cells. Although the DNAM-1 ligand CD155 is ubiquitously expressed in various tissues, many human tumors significantly upregulate the expression of CD155; DNAM-1 on CTL and NK cells may be involved in tumor immunity. However, unlike those in mice, human tissues also express soluble isoforms of CD155 (sCD155) that lack the transmembrane region. Here, we show that sCD155 levels were significantly higher in the sera of 262 patients with lung, gastrointestinal, breast, and gynecologic cancers than in sera from healthy donors. In addition, the sCD155 levels were significantly higher in patients with early stage (stages 1 and 2) gastric cancer than in healthy donors, and were significantly higher in patients with advanced stage (stages 3 and 4) disease than in patients in those with early stage disease and healthy donors. Moreover, the sCD155 levels were significantly decreased after surgical resection of cancers. Thus, sCD155 level in serum may be potentially useful as a biomarker for cancer development and progression.
authors.affiliation: Department of Breast and Endocrine Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.|Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Iguchi-Manaka
authors.affiliation: Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Genki
authors.initials: G
authors.lastname: Okumura
authors.affiliation: Ibaraki Clinical Education and Training Center, University of Tsukuba Hospital, Tsukuba, Japan.|Department of Clinical Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kojima
authors.affiliation: Department of Clinical Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Hirochika
authors.affiliation: Department of Breast and Endocrine Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Bando
authors.affiliation: Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Toyomi
authors.initials: T
authors.lastname: Sato
authors.affiliation: Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: Department of Breast and Endocrine Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hisato
authors.initials: H
authors.lastname: Hara
authors.affiliation: Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.|Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), University of Tsukuba, Tsukuba, Japan.|Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan.|AMED-CREST, AMED, Japan Agency for Medical Research and Development, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shibuya
authors.affiliation: Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Shibuya
mesh_terms: D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000473:pathology; D011991:Receptors, Virus / Q000097:blood*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D014408:Biomarkers, Tumor; D011991:Receptors, Virus; C066100:poliovirus receptor