title: High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences.
abstract: A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected substrates within minutes using acetonitrile as the solvent and without the use of acidic conditions or additional workups. Highly efficient, multistep reaction sequences in flow are also demonstrated wherein no extraction or isolation was required between steps.
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Bogdan
authors.affiliation: Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66047, United States.
authors.forename: Manwika
authors.initials: M
authors.lastname: Charaschanya
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Amanda W
authors.initials: AW
authors.lastname: Dombrowski
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric