title: Curcumin-loaded silica-based mesoporous materials: Synthesis, characterization and cytotoxic properties against cancer cells.
abstract: Two different silica based (MSU-2 and MCM-41) curcumin loaded mesoporous materials V3 and V6 were synthesized and characterized by several physico-chemical techniques. Release kinetic study revealed the slow and sustained release of curcumin from those materials in blood simulated fluid (pH: 7.4). The materials V3 and V6 were found to be biocompatible in non-cancerous CHO cell line while exhibiting significant cytotoxicity in different cancer cells (human lung carcinoma cells: A549, human breast cancer cells: MCF-7, mouse melanoma cells: B16F10) compared to pristine curcumin indicating the efficacy of the mesoporous silica materials based drug delivery systems (DDSs). The generation of intracellular reactive oxygen species (ROS) and down regulation of anti-apoptotic protein leading to the induction of apoptosis were found to be the plausible mechanisms behind the anti-cancer activity of these DDSs. These results suggest that curcumin-loaded drug delivery system may be successfully employed as an alternative treatment strategy for cancer therapeutics through a nanomedicine approach in near future.
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India.
authors.forename: Vishnu Sravan
authors.initials: VS
authors.lastname: Bollu
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India.
authors.forename: Ayan Kumar
authors.initials: AK
authors.lastname: Barui
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India.
authors.forename: Sujan Kumar
authors.initials: SK
authors.lastname: Mondal
authors.affiliation: Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, 28933, Móstoles, Madrid, Spain.
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Prashar
authors.affiliation: Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, 28933, Móstoles, Madrid, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Fajardo
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Facultad de Ciencias, Fuente Nueva s/n 18071, Granada, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Briones
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Facultad de Ciencias, Fuente Nueva s/n 18071, Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rodríguez-Diéguez
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India. Electronic address: crpatra@iict.res.in.
authors.forename: Chitta Ranjan
authors.initials: CR
authors.lastname: Patra
authors.affiliation: Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, 28933, Móstoles, Madrid, Spain. Electronic address: santiago.gomez@urjc.es.
authors.forename: Santiago
authors.initials: S
authors.lastname: Gómez-Ruiz
mesh_terms: D000072283:A549 Cells; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D005434:Flow Cytometry; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D050997:Nanomedicine; D016062:Porosity; D017382:Reactive Oxygen Species; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; C509968:MCM-41; D017382:Reactive Oxygen Species; D012822:Silicon Dioxide; D003474:Curcumin
keywords: Anti-cancer; Curcumin; Cytotoxicity; Mesoporous silica materials; Nanomedicine