title: High Level of Serum Myoglobin in Human Intracerebral Hemorrhage: Implications for Large Hematoma Volume and Growth.
abstract: BACKGROUND
  Myoglobin and cardiac troponin T are often elevated in patients with ischemic stroke. However, the association, if any, between both myoglobin and troponin T levels and hematoma volume in patients with intracerebral hemorrhage remains to be established. We investigate the possible relationship between admission myoglobin and troponin T levels and hematoma volume and growth.
  
  
  METHODS
  A total of 143 patients with intracerebral hemorrhage admitted within 72 hours after symptom onset were divided into 4 groups according to the quartile of myoglobin levels. The information of hematoma was assessed with computed tomography scans. Serum myoglobin and cardiac troponin were tested at admission. The relationship between myoglobin levels and hematoma volume and growth was performed using univariate and multiple logistic regression and linear regression.
  
  
  RESULTS
  High levels of serum myoglobin were associated with larger hematoma volume. In the highest quartile compared with the lowest quartile of myoglobin, the crude and adjusted odds ratios for the incidence of baseline hematoma volume greater than 30 mL were 2.14 (95% confidence interval 1.45-3.15) and 2.78 (95% confidence interval 1.57-5.00), respectively, in logistic regression. In linear regression, the adjusted B for the relationship of myoglobin and hematoma volume and the change of hematoma volume was .02 (95% confidence interval .01-.04, P = .007) and .021 (95% confidence interval .01-.03, P < .001), respectively, whereas high level of troponin T was not associated with large hematoma volume.
  
  
  CONCLUSIONS
  Our results first demonstrate that myoglobin is associated with larger hematoma volume and growth after adjusting potential confounding factors.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Mangmang
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Lei
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ruozhen
authors.initials: R
authors.lastname: Yuan
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Tan
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Center of Cerebrovascular Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address: wyplmh@hotmail.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006406:Hematoma / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009211:Myoglobin / Q000097:blood*; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D020107:Troponin T / Q000097:blood; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D020107:Troponin T
keywords: Myoglobin; hematoma growth; hematoma volume; intracerebral hemorrhage