title: Clinical Characteristics and 30-Day Outcomes of Intermittent Hemodialysis for Acute Kidney Injury in an African Intensive Care Unit.
abstract: BACKGROUND
  Acute kidney injury (AKI) is a common occurrence in the intensive care unit (ICU). Studies have looked at outcomes of renal replacement therapy using intermittent haemodialysis (IHD) in ICUs with varying results. Little is known about the outcomes of using IHD in resource-limited settings where continuous renal replacement therapy (CRRT) is limited. We sought to determine outcomes of IHD among critically ill patients admitted to a low-income country ICU.
  
  
  METHODS
  A retrospective review of patient records was conducted. Patients admitted to the ICU who underwent IHD for AKI were included in the study. Patients' demographic and clinical characteristics, cause of AKI, laboratory parameters, haemodialysis characteristics, and survival were interpreted and analyzed. Primary outcome was mortality.
  
  
  RESULTS
  Of 62 patients, 40 had complete records. Median age of patients was 38.5 years. Etiologic diagnoses associated with AKI included sepsis, malaria, and ARDS. Mortality was 52.5%. APACHE II (OR 4.550; 95% CI 1.2-17.5, p = 0.028), mechanical ventilation (OR 13.063; 95% CI 2.3-72, p = 0.003), and need for vasopressors (OR 16.8; 95% CI 3.4-82.6, p = 0.001) had statistically significant association with mortality.
  
  
  CONCLUSIONS
  IHD may be a feasible alternative for RRT in critically ill haemodynamically stable patients in low resource settings where CRRT may not be available.
authors.affiliation: Department of Anaesthesia, Makerere University, P.O. Box 7072, Kampala, Uganda; Dialysis and Intensive Care Unit, International Hospital Kampala, P.O. Box 8177, Kampala, Uganda.
authors.forename: Arthur
authors.identifier: 0000-0002-7025-0465
authors.initials: A
authors.lastname: Kwizera
authors.affiliation: Department of Anaesthesia, Makerere University, P.O. Box 7072, Kampala, Uganda.
authors.forename: Janat
authors.initials: J
authors.lastname: Tumukunde
authors.affiliation: Department of Anaesthesia, Makerere University, P.O. Box 7072, Kampala, Uganda.
authors.forename: Lameck
authors.initials: L
authors.lastname: Ssemogerere
authors.affiliation: Department of Anaesthesia, Makerere University, P.O. Box 7072, Kampala, Uganda.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ayebale
authors.affiliation: Department of Anaesthesia, Makerere University, P.O. Box 7072, Kampala, Uganda.
authors.forename: Peter
authors.initials: P
authors.lastname: Agaba
authors.affiliation: Dialysis and Intensive Care Unit, International Hospital Kampala, P.O. Box 8177, Kampala, Uganda.
authors.forename: Jamali
authors.initials: J
authors.lastname: Yakubu
authors.affiliation: Department of Anaesthesia, Makerere University, P.O. Box 7072, Kampala, Uganda.
authors.forename: Aggrey
authors.initials: A
authors.lastname: Lubikire
authors.affiliation: Department of Anaesthesia, Makerere University, P.O. Box 7072, Kampala, Uganda.
authors.forename: Mary
authors.initials: M
authors.lastname: Nabukenya
authors.affiliation: Departments of Physiology and Internal Medicine Nephrology Unit, Makerere University, P.O. Box 7072, Kampala, Uganda.
authors.forename: Robert
authors.identifier: 0000-0003-3211-163X
authors.initials: R
authors.lastname: Kalyesubula
mesh_terms: D018806:APACHE; D058186:Acute Kidney Injury / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D000349:Africa; D000368:Aged; D016638:Critical Illness; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D017582:Renal Replacement Therapy / Q000379:methods; D012772:Shock, Septic / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*