title: Long-Term Follow-Up in Patients With Airway Chemical Intolerance.
abstract: OBJECTIVE
  A 5-year follow-up study showed that a group of patients with airway symptoms from chemicals and scents had lasting symptoms, together with enduring increased capsaicin cough sensitivity. The aim was to follow up the same patients after another 5 years.
  
  
  METHODS
  All previously participants were invited for an additional follow-up. They visited the clinic twice; at one opportunity, they undertook a capsaicin inhalation provocation, and at the other, a methacholine provocation, and answered various questionnaires.
  
  
  RESULTS
  Sixteen patients attende the study after a median of 8 years. They reported unchanged symptoms from chemicals and scents; the capsaicin cough sensitivity was still increased, and the repeatability for the capsaicin inhalation was good.
  
  
  CONCLUSIONS
  Airway symptoms induced by chemicals and scents constitute a chronic disease, with unchanged trigger factors, persistent symptoms, and unchanged, long-lasting sensory hyperreactivity.All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.This study was supported by grants from the Herman Krefting Foundation Against Asthma/Allergy, the Swedish Heart and Lung Foundation, and the Swedish Cancer and Allergy Fund.
authors.affiliation: Department of Respiratory Medicine and Allergology, Institution of Medicine, The Sahlgrenska Academy at University of Gothenburg, Sweden.
authors.forename: Ewa
authors.initials: E
authors.lastname: Ternesten-Hasséus
mesh_terms: D000328:Adult; D000368:Aged; D001985:Bronchial Provocation Tests; D002211:Capsaicin / Q000494:pharmacology; D002908:Chronic Disease; D003371:Cough / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity / Q000209:etiology / Q000503:physiopathology*; D010476:Perfume / Q000009:adverse effects; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000503:physiopathology*; D012882:Skin Tests; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D010476:Perfume; D016210:Methacholine Chloride; D002211:Capsaicin