title: Proof of principle for bevacizumab activity in desmoid-type fibromatosis.
abstract: BACKGROUND
  Desmoid-type fibromatosis (DF) is a rare disease, which often occurs in young adults. Medical treatment is an important option in the treatment algorithm of DF. Different chemotherapeutic regimens showed clinical activity in DF, but overall treatment tolerability remains poor for this patient cohort. Novel approaches investigated tyrosine kinase inhibitors in DF, but tolerability remained an issue.
  
  
  METHODS
  We treated a patient with progressive DF after failure of chemotherapy for 1 year with singe agent bevacizumab. He achieved a symptomatic and radiologic response while attainning excellent tolerability.
  
  
  CONCLUSIONS
  This is the first report on single agent bevacizumab in DF, which showed both, good tolerability and efficacy in our patient, thereby warranting future trials in DF.
authors.affiliation: Clinic for Hematology, Hemostasis, Oncology and Stemcelltransplantation, Medical School Hannover, Carl-Neuberg-Str. 1, Hannover, Germany.
authors.forename: Viktor
authors.identifier: 0000-0003-2083-7687
authors.initials: V
authors.lastname: Grünwald
authors.affiliation: Department of Pathology, Medical School Hannover, Hannover, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Länger
authors.affiliation: Department of Radiology, Medical School Hannover, Hannover, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Raatschen
authors.affiliation: Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Beilken
keywords: Aggressive fibromatosis; Anti-angiogenic therapy; Bevacizumab; Desmoid