title: Inhibitory Effects of Gallic Acid Isolated from Caesalpinia mimosoides Lamk on Cholangiocarcinoma Cell Lines and Foodborne Pathogenic Bacteria.
abstract: Gallic acid was isolated from Caesalpinia mimosoides Lamk and the structure s identified based on spectroscopic analysis and comparison with authentic compound. In this study we compared the ability of natural gallic acid (nGA) and commercial gallic acid (cGA) to inhibit the proliferation of cholangiocarcinoma cell lines (M213, M214) and foodborne pathogenic bacteria (Salmonella spp. and Plesiomonas shigelloides). Both nGA and cGA had the same inhibitory effects on cell proliferation by inducing apoptosis of cholangiocarcinoma cell lines. In addition, nGA inhibited growth of foodborne pathogenic bacteria in the same manner as cGA. Our results suggest that nGA from Caesalpinia mimosoides Lamk is a potential anticancer and antibacterial compound. However, in vivo studies are needed to elucidate the specific mechanisms involved.
authors.affiliation: Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand E-mail : jurpoo@kku.ac.th.
authors.forename: Narintorn
authors.initials: N
authors.lastname: Rattanata
authors.forename: Sompong
authors.initials: S
authors.lastname: Klaynongsruang
authors.forename: Sakda
authors.initials: S
authors.lastname: Daduang
authors.forename: Ratree
authors.initials: R
authors.lastname: Tavichakorntrakool
authors.forename: Temduang
authors.initials: T
authors.lastname: Limpaiboon
authors.forename: Ratsami
authors.initials: R
authors.lastname: Lekphrom
authors.forename: Patcharee
authors.initials: P
authors.lastname: Boonsiri
authors.forename: Jureerut
authors.initials: J
authors.lastname: Daduang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000187:drug effects* / Q000473:pathology; D029911:Caesalpinia / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D018281:Cholangiocarcinoma / Q000188:drug therapy* / Q000473:pathology; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000188:drug therapy* / Q000473:pathology; D005707:Gallic Acid / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D016981:Plesiomonas / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D005707:Gallic Acid