title: The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia.
authors.affiliation: Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Anna
authors.initials: A
authors.lastname: Wojtuszkiewicz
authors.affiliation: Dept. of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Yehuda G
authors.initials: YG
authors.lastname: Assaraf
authors.affiliation: Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Mirthe
authors.initials: M
authors.lastname: Hoekstra
authors.affiliation: Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Rocco
authors.initials: R
authors.lastname: Sciarrillo
authors.affiliation: Dept. of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Gerrit
authors.initials: G
authors.lastname: Jansen
authors.affiliation: Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Godefridus J
authors.initials: GJ
authors.lastname: Peters
authors.affiliation: Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
authors.forename: Rob
authors.initials: R
authors.lastname: Pieters
authors.affiliation: Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands.
authors.forename: Edwin
authors.initials: E
authors.lastname: Sonneveld
authors.affiliation: Clinic of Pediatric Hematology/Oncology, University Medical Center Eppendorf, Hamburg, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Escherich
authors.affiliation: Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Gertjan J L
authors.initials: GJ
authors.lastname: Kaspers
authors.affiliation: Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands j.cloos@vumc.nl.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Cloos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000401:mortality; D012326:RNA Splicing; D015996:Survival Rate
chemical_list: D009363:Neoplasm Proteins; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate
keywords: aberrant splicing; dexamethasone; folylpolyglutamate synthetase; methotrexate; pediatric acute lymphoblastic leukemia