title: The effect of gabapentin and pregabalin on intestinal incision wound healing in rabbits.
abstract: OBJECTIVE
  To evaluate the macroscopic and histologic effects of pregabalin (PG) gabapentin (GB) on longitudinal intestinal wound healing in New Zealand rabbits.
  
  
  METHODS
  The animals were divided into three groups randomly; the control group (n=6), PG group (n=6) and GB group (n=6). All animals were premedicated with xylazine HCI, 5 mg/kg i.m. and general anaesthesia was performed by ketamine HCI 50 mg/kg i.m injection. A 4 cm incision in the caecum through median laparotomy was achieved under aseptic surgery. Intestinal wound was closed with double-sutured. All animals were received parenteral antibiotic treatment for 5 days. PG and GB groups were treated by PG (30 mg/kg, oral, daily) and GB (30 mg/kg, oral, daily) for 10 days respectively. Control group did not receive any treatment. The animals were euthanized on day 10 and the caecum was examined by laparotomy. Adhesion formation was observed, and tissue samples were taken from suture lines for histologic examination. Cellular infiltration (polymorphonuclear white blood cells and mononuclear cells), accumulation of connective tissue, vascularization and extent of necrosis were evaluated and scored separately for each of mucosal, submucosal, muscular and serosal layers of caecum.
  
  
  RESULTS
  Adhesions were more severe in the GB group compared to other groups. No statistically significant differences were detected among the three groups about the wound healing.
  
  
  CONCLUSIONS
  It was suggested that the use of gabapentinoids had no significant effect on wound healing in patients undergoing gastrointestinal surgery and further studies with treatment periods longer than 10 days are needed.
authors.affiliation: Department of Surgery, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Korkmaz
authors.affiliation: Department of Anaesthesiology and Reanimation, Meram Medical School, Necmettin Erbakan University, 42080, Konya, Turkey.
authors.forename: T B
authors.initials: TB
authors.lastname: Saritas
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Sevimli
authors.affiliation: Department of Surgery, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey.
authors.forename: Z K
authors.initials: ZK
authors.lastname: Saritas
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Elitok
keywords: gabapentin; intestinal incisional wound; pregabalin; rabbit