title: Serum vaspin concentrations in girls with anorexia nervosa.
abstract: BACKGROUND
  Vaspin (VASP) is a protein detected in pre- and mature adipocytes, the production and secretion of which may be conditioned by nutrition status. VASP may also play a role in the regulation of food intake. Since to date, there are no available studies on serum vaspin concentrations in patients with anorexia nervosa (AN), the aim of our study is to assess serum vaspin concentrations in girls with AN in comparison to healthy subjects and determine its relationship with body weight, body masss index (BMI) and insulin.
  
  
  METHODS
  In this cross-sectional study vaspin serum concentrations were evaluated using a commercially available ELISA kit in 47 Polish girls hospitalized due to restrictive AN and 39 healthy controls (H).
  
  
  RESULTS
  The mean serum concentration of VASP in girls with AN was significantly higher than in the H group. These differences were also noted after adjustment for body masss index-standard deviation score (BMI-SDS), the homeostatic model assessment-insulin resistance (HOMA-IR) index and insulin levels. There were no statistically significant correlations between the serum concentrations of VASP and body mass, BMI, BMI-SDS, insulin and HOMA-IR in the AN or healthy group.
  
  
  CONCLUSIONS
  Serum vaspin levels in lean subjects are regulated in different mechanisms than previously reported in obesity. It should be established if elevated serum vaspin levels in girls with AN may contribute to low food intake in these patients.
authors.forename: Joanna
authors.initials: J
authors.lastname: Oświęcimska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Suwała
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Świętochowska
authors.forename: Zofia
authors.initials: Z
authors.lastname: Ostrowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Gorczyca
authors.forename: Karolina
authors.initials: K
authors.lastname: Ziora-Jakutowicz
authors.forename: Edyta
authors.initials: E
authors.lastname: Machura
authors.forename: Maria
authors.initials: M
authors.lastname: Szczepańska
authors.forename: Lidia
authors.initials: L
authors.lastname: Hyla-Klekot
authors.forename: Michał
authors.initials: M
authors.lastname: Kukla
authors.forename: Dariusz
authors.initials: D
authors.lastname: Ziora
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ziora
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015843:Serpins / Q000097:blood*
chemical_list: C507339:SERPINA12 protein, human; D015843:Serpins