title: Synthesis of Water-Soluble, Thiolate-Protected Gold Nanoparticles Uniform in Size.
abstract: By a modification of the method of Brust et al., water-soluble, thiolate-protected gold nanoparticles that are uniform in size were synthesized with no requirement for purification. The modification of the method was equilibration in the first step, which proved crucial for achieving size homogeneity. The thiol-to-gold ratio controlled the size of the particles, and the choice of thiol controlled the reactivity of the particles toward thiol exchange.
authors.affiliation: Department of Structural Biology, Stanford University School of Medicine , Stanford, California 94305, United States.
authors.forename: Maia
authors.initials: M
authors.lastname: Azubel
authors.affiliation: Department of Structural Biology, Stanford University School of Medicine , Stanford, California 94305, United States.
authors.forename: Roger D
authors.initials: RD
authors.lastname: Kornberg
mesh_terms: D006046:Gold / Q000737:chemistry*; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission / Q000379:methods; D010316:Particle Size; D057127:Single-Chain Antibodies / Q000737:chemistry; D012995:Solubility; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013499:Surface Properties; D014867:Water
chemical_list: D008024:Ligands; D057127:Single-Chain Antibodies; D013438:Sulfhydryl Compounds; D014867:Water; D006046:Gold
keywords: Water-soluble gold nanoparticles; bioconjugation; ligand exchange