title: The effect of first trimester subchorionic hematoma on pregnancy outcomes in patients underwent IVF/ICSI treatment.
abstract: OBJECTIVE
  The aim of this retrospective cohort study was to assess the effect of subchorionic hematoma (SCH) on pregnancy outcomes in IVF/ICSI patients.
  
  
  METHODS
  We retrospectively analyzed 1097 pregnancies achieved by in vitro fertilization and embryo transfer (IVF-ET) or frozen-thawed embryo transfers (FETs) between January 2013 and June 2013 at the IVF center of Nanjing Drum Tower Hospital. The prevalence of SCH was 12.1% in this group (133/1097). We compared the pregnancy outcomes between the SCH group and non-SCH group, while the risk factors for SCH were also evaluated.
  
  
  RESULTS
  There was no significant difference between SCH group and non-SCH group with regard to patients' age, spouse's age, endometrial thickness, miscarriage rate (5.6% versus 6.2%, p > 0.05), second trimester fetus loss rate (5.6% versus 7.7%, p > 0.05) or live birth rate (89.5% versus 86.1%, p > 0.05). While the birth weight in singleton pregnancy in SCH group was significant lower (3207.8 ± 595.7 g versus 3349.2 ± 59.7 g, p = 0.03). SCH was more common in fresh embryo transfer patients than that in FET patients (16.6% versus 5.1%, p < 0.01), fresh embryo transfer was a high risk for SCH with OR 3.67, 95% CI: 2.28-5.90.
  
  
  CONCLUSIONS
  We concluded that SCH was associated with lower birth weight in singleton pregnancy, but SCH did not increase pregnancy loss rate in IVF/ICSI patients, and fresh embryo transfer may contribute to SCH onset.
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Xiaoni
authors.initials: X
authors.lastname: Hou
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Ningyuan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Hu
authors.affiliation: a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.
authors.forename: Haixiang
authors.initials: H
authors.lastname: Sun
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D002823:Chorion; D004624:Embryo Transfer / Q000009:adverse effects* / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects* / Q000379:methods; D006406:Hematoma / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects / Q000379:methods; D016216:Ultrasonography, Prenatal
keywords: ICSI; IVF; pregnancy outcome; subchorionic hematoma