title: Boost for Alginate Encapsulation in Beta Cell Transplantation.
abstract: A recent study reported that encapsulation of human embryonic stem cell (hESC)-derived beta cells by a novel alginate formula protects against foreign body reactivity in immune-competent mice. Intraperitoneal implants corrected a diabetic state for at least 6 months. These observations will stimulate the development of alginate encapsulation towards novel cell therapy protocols for treating type 1 diabetes (T1DM).
authors.affiliation: Diabetes Research Center, Brussels Free University and University Hospital Brussels, Center for Beta Cell Therapy in Diabetes, 1090 Brussels, Belgium. Electronic address: Daniel.Pipeleers@vub.ac.be.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pipeleers
authors.affiliation: Diabetes Research Center, Brussels Free University and University Hospital Brussels, Center for Beta Cell Therapy in Diabetes, 1090 Brussels, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Keymeulen
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D004339:Drug Compounding; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D016381:Islets of Langerhans Transplantation; D051379:Mice
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid
keywords: human embryonic stem cells; islet cell transplantation; microencapsulation