title: Preparation of porous carboxymethyl chitosan grafted poly (acrylic acid) superabsorbent by solvent precipitation and its application as a hemostatic wound dressing.
abstract: The volume phase transition of a hydrogel initiated by shrinking may result in complex patterns on its surface. Based on this unique property of hydrogel, we have developed a novel solvent precipitation method to prepare a kind of novel superabsorbent polymers with excellent hemostatic properties. A porous carboxymethyl chitosan grafted poly (acrylic acid) (CMCTS-g-PAA) superabsorbent polymer was prepared by precipitating CMCTS-g-PAA hydrogel with ethanol. Its potential application in hemostatic wound dressing was investigated. The results indicate that the modified superabsorbent polymer is non-cytotoxic. It showed a high swelling capacity and better hemostatic performance in the treatments of hemorrhage model of ear artery, arteria cruralis and spleen of the New Zealand white rabbit than the unmodified polymer and other commonly used clinic wound dressings. The hemostatic mechanism of the porous CMCTS-g-PAA polymer was also discussed.
authors.affiliation: School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: cylsy@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Fengju
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Meng
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Xinlin
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: State Key Laboratory of Trauma Burns and Combined Injury, The Third Military Medical University, Chongqing 400042, PR China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Jiang
authors.affiliation: School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Tan
authors.affiliation: Guangdong Fuyang Biotechnology Co., Ltd., Heyuan, Guangdong 517000, PR China.
authors.forename: Yongfa
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D006367:HeLa Cells; D006461:Hemolysis / Q000187:drug effects; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D016062:Porosity; D011817:Rabbits; D012997:Solvents / Q000737:chemistry*; D023382:Toxicity Tests, Acute
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D020100:Hydrogels; D012997:Solvents; C514968:carboxymethyl-chitosan; C006903:carbopol 940; D048271:Chitosan
keywords: Chitosan; Hemostatic wound dressing; Modification; Solvent precipitation method; Superabsorbent polymer