title: Relation of fetuin A levels with cardiac, subcutaneous lipid accumulation and insulin resistance parameters in Turkish obese children.
abstract: BACKGROUND
  Fetuin A is an inhibitor of insulin action and have been found to be related with subcutaneous lipid accumulation and insulin resistance. The relation of cardiac lipid accumulation, fetuin A and insulin resistance parameters in obese children is not well-known. The aim of the study was to evaluate the relation of serum fetuin A levels with subcutaneous and cardiac lipid accumulation, and insulin resistance parameters in Turkish obese children.
  
  
  METHODS
  Serum fetuin A levels, cardiac and subcutaneous lipid accumulation parameters of 42 obese (10.9±2.3 years, 19 female) and 40 control group subjects (11.2±2.7) were compared. Cardiac lipid accumulation measured by subepicardial adipose tissue thickness. Insulin resistance was assessed using homeostasis model assessment (HOMA-IR) index.
  
  
  RESULTS
  There were significant correlations serum fetuin A levels with BMI-SDS, circumferences of waist, hip and midarm, SATT and HOMA-IR (r=0.362, p=0.018, r=0.728, p=0.001, r=0.662, p=0.0001, r=0.713, p=0.0001, r=0.477, p=0.001, and r=0.330, p=0.038 as, respectively).
  
  
  CONCLUSIONS
  Fetuin A was correlated well with cardiac and subcutaneous lipid accumulation, insulin resistance parameters, which may be related with early pathogenetic mechanisms of metabolic obesity complications in children.
authors.forename: Şamil
authors.initials: Ş
authors.lastname: Hızlı
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abacı
authors.forename: Osman
authors.initials: O
authors.lastname: Özdemir
authors.forename: Zülfikar
authors.initials: Z
authors.lastname: Akelma
authors.forename: Okhan
authors.initials: O
authors.lastname: Akın
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis*
chemical_list: D060749:alpha-2-HS-Glycoprotein