title: Positron detection in silica monoliths for miniaturised quality control of PET radiotracers.
abstract: We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [(68)Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.
authors.affiliation: Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Tarn
authors.forename: Dzmitry
authors.initials: D
authors.lastname: Maneuski
authors.forename: Richard
authors.initials: R
authors.lastname: Alexander
authors.forename: Nathaniel J
authors.initials: NJ
authors.lastname: Brown
authors.forename: Val
authors.initials: V
authors.lastname: O'Shea
authors.forename: Sally L
authors.initials: SL
authors.lastname: Pimlott
authors.forename: Nicole
authors.initials: N
authors.lastname: Pamme
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Archibald
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002951:Citrates / Q000737:chemistry; D005708:Gallium / Q000737:chemistry; D005710:Gallium Radioisotopes / Q000737:chemistry; D008904:Miniaturization; D049268:Positron-Emission Tomography / Q000592:standards*; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000737:chemistry*; D059629:Signal-To-Noise Ratio; D012822:Silicon Dioxide / Q000737:chemistry*; D012974:Sodium Iodide / Q000737:chemistry
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D012822:Silicon Dioxide; C000615430:Gallium-68; D005708:Gallium; D012974:Sodium Iodide; C103850:gallium citrate