title: Enantioselective Synthesis of Silacyclopentanes.
abstract: A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.
authors.affiliation: Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka, 816-8580, Japan. kigawa@cm.kyushu-u.ac.jp.
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Igawa
authors.affiliation: Department of Molecular and Material Sciences, Kyushu University, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshihiro
authors.affiliation: Department of Molecular and Material Sciences, Kyushu University, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Abe
authors.affiliation: Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka, 816-8580, Japan. ktomooka@cm.kyushu-u.ac.jp.
authors.forename: Katsuhiko
authors.identifier: 0000-0002-0762-5746
authors.initials: K
authors.lastname: Tomooka
keywords: asymmetric synthesis; biological activity; chirality; elimination; silicon