title: Computer Aided Detection System for Prediction of the Malaise during Hemodialysis.
abstract: Monitoring of dialysis sessions is crucial as different stress factors can yield suffering or critical situations. Specialized personnel is usually required for the administration of this medical treatment; nevertheless, subjects whose clinical status can be considered stable require different monitoring strategies when compared with subjects with critical clinical conditions. In this case domiciliary treatment or monitoring can substantially improve the quality of life of patients undergoing dialysis. In this work, we present a Computer Aided Detection (CAD) system for the telemonitoring of patients' clinical parameters. The CAD was mainly designed to predict the insurgence of critical events; it consisted of two Random Forest (RF) classifiers: the first one (RF1) predicting the onset of any malaise one hour after the treatment start and the second one (RF2) again two hours later. The developed system shows an accurate classification performance in terms of both sensitivity and specificity. The specificity in the identification of nonsymptomatic sessions and the sensitivity in the identification of symptomatic sessions for RF2 are equal to 86.60% and 71.40%, respectively, thus suggesting the CAD as an effective tool to support expert nephrologists in telemonitoring the patients.
authors.affiliation: Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70125 Bari, Italy.
authors.forename: Sabina
authors.identifier: 0000-0002-1372-3916
authors.initials: S
authors.lastname: Tangaro
authors.affiliation: Dipartimento Interateneo di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Via Orabona 4, 70125 Bari, Italy.
authors.forename: Annarita
authors.initials: A
authors.lastname: Fanizzi
authors.affiliation: Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70125 Bari, Italy; Dipartimento Interateneo di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Via Orabona 4, 70125 Bari, Italy.
authors.forename: Nicola
authors.identifier: 0000-0003-0211-0783
authors.initials: N
authors.lastname: Amoroso
authors.affiliation: Nephrology, Dialysis and Transplantation Unit, University of Bari "A. Moro", Piazza G. Cesare, 11 - Policlinico, 70124 Bari, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Corciulo
authors.affiliation: Department of Physical Sciences, Earth and Environment, University of Siena, Strada Laterina 8, 53100 Siena, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Garuccio
authors.affiliation: Nephrology, Dialysis and Transplantation Unit, University of Bari "A. Moro", Piazza G. Cesare, 11 - Policlinico, 70124 Bari, Italy.
authors.forename: Loreto
authors.initials: L
authors.lastname: Gesualdo
authors.affiliation: Nephrology, Dialysis and Transplantation Unit, University of Bari "A. Moro", Piazza G. Cesare, 11 - Policlinico, 70124 Bari, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Loizzo
authors.affiliation: Nephrology, Dialysis and Transplantation Unit, University of Bari "A. Moro", Piazza G. Cesare, 11 - Policlinico, 70124 Bari, Italy.
authors.forename: Deni Aldo
authors.initials: DA
authors.lastname: Procaccini
authors.affiliation: Nephrology, Dialysis and Transplantation Unit, University of Bari "A. Moro", Piazza G. Cesare, 11 - Policlinico, 70124 Bari, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Vernò
authors.affiliation: Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70125 Bari, Italy; Dipartimento Interateneo di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Via Orabona 4, 70125 Bari, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bellotti
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001794:Blood Pressure; D003199:Computer Systems; D003936:Diagnosis, Computer-Assisted; D004244:Dizziness / Q000175:diagnosis* / Q000209:etiology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000523:psychology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000175:diagnosis* / Q000209:etiology; D009325:Nausea / Q000175:diagnosis* / Q000209:etiology; D010363:Pattern Recognition, Automated; D011788:Quality of Life; D012372:ROC Curve; D019114:Remote Consultation / Q000379:methods; D006435:Renal Dialysis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors