title: Neural model of gene regulatory network: a survey on supportive meta-heuristics.
abstract: Gene regulatory network (GRN) is produced as a result of regulatory interactions between different genes through their coded proteins in cellular context. Having immense importance in disease detection and drug finding, GRN has been modelled through various mathematical and computational schemes and reported in survey articles. Neural and neuro-fuzzy models have been the focus of attraction in bioinformatics. Predominant use of meta-heuristic algorithms in training neural models has proved its excellence. Considering these facts, this paper is organized to survey neural modelling schemes of GRN and the efficacy of meta-heuristic algorithms towards parameter learning (i.e. weighting connections) within the model. This survey paper renders two different structure-related approaches to infer GRN which are global structure approach and substructure approach. It also describes two neural modelling schemes, such as artificial neural network/recurrent neural network based modelling and neuro-fuzzy modelling. The meta-heuristic algorithms applied so far to learn the structure and parameters of neutrally modelled GRN have been reviewed here.
authors.affiliation: Department of Computer Science and Engineering, West Bengal University of Technology (WBUT), BF-142, Sector-I, Salt Lake, Kolkata, India. surama.biswas@gmail.com.
authors.forename: Surama
authors.identifier: http://orcid.org/0000-0001-5979-3605
authors.initials: S
authors.lastname: Biswas
authors.affiliation: Department of Computer Science and Engineering, West Bengal University of Technology (WBUT), BF-142, Sector-I, Salt Lake, Kolkata, India.
authors.forename: Sriyankar
authors.initials: S
authors.lastname: Acharyya
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D053263:Gene Regulatory Networks; D000066506:Heuristics; D006801:Humans; D008957:Models, Genetic; D008962:Models, Theoretical; D016571:Neural Networks, Computer
keywords: Gene regulatory network; Meta-heuristic algorithm; Microarray gene expression data; Neuro-fuzzy modelling; Optimization; Recurrent neural network