title: Dissemination of metal resistance genes among animal methicillin-resistant coagulase-negative Staphylococci.
abstract: The use of metals as feed supplement has been recognized as a potential driver for co-selection of methicillin-resistant Staphylococcus aureus in pigs. However, the prevalence of these determinants in methicillin-resistant coagulase-negative staphylococci (MRCoNS) is largely unknown. In this study, a collection of 130 MRCoNS from pigs and veal calves were investigated for the presence of metal-resistance genes (czrC, copB, cadD, arsA) associated to SCCmec. Near half of the isolates carried metal resistance genes (czrC 5.4%, copB 38.5%, cadD 7.7%, arsA 26.2%) regardless of their SCCmec type. The increased use of metals in livestock animals, especially zinc in pigs in several European countries may co-select for methicillin-resistance in several staphylococcal species.
authors.affiliation: Department of Bacterial Diseases, Veterinary and Agrochemical Research Centre, Brussels, Groeselenbergstraat 99, B-1180 Ukkel, Belgium. Electronic address: maria.argudin@erasme.ulb.ac.be.
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Argudín
authors.affiliation: Department of Bacterial Diseases, Veterinary and Agrochemical Research Centre, Brussels, Groeselenbergstraat 99, B-1180 Ukkel, Belgium; Department of Pathology, Bacteriology, and Avian Diseases, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium. Electronic address: pbutaye@rossvet.edu.kn.
authors.forename: Patrick
authors.initials: P
authors.lastname: Butaye
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D003030:Coagulase / Q000235:genetics; D004351:Drug Resistance; D008670:Metals / Q000494:pharmacology*; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics / Q000378:metabolism; D013203:Staphylococcal Infections / Q000382:microbiology / Q000662:veterinary*; D013210:Staphylococcus / Q000235:genetics* / Q000378:metabolism; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*
chemical_list: D003030:Coagulase; D008670:Metals
keywords: Copper; Methicillin resistance; Zinc