title: Toxic Epidermal Necrolysis with Gastrointestinal Involvement: A Case Report and Review of the Literature.
abstract: Gastrointestinal involvement is a rare complication of toxic epidermal necrolysis syndrome (TENS) that results in sloughing of the intestinal epithelium. Prior case reports have noted the potential susceptibility of the entire gastrointestinal tract, from oropharynx and esophagus to sigmoid colon and rectum. Given its infrequency, the effect of gastrointestinal involvement on the treatment and prognosis of TENS is poorly understood. Here, the authors report a case of gastrointestinal symptoms in a patient diagnosed with toxic epidermal necrolysis, likely representing gastrointestinal involvement. In addition, the authors describe the histopathologic and endoscopic characteristics of the involved mucosa, clinical course, and present a review of the literature of this rare but potentially impactful complication of TENS.
authors.affiliation: From the *Department of Surgery, and †Department of Pathology, University of Chicago Medicine, Illinois.
authors.forename: Craig S
authors.initials: CS
authors.lastname: Brown
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Defazio
authors.forename: Gary
authors.initials: G
authors.lastname: An
authors.forename: Annemarie
authors.initials: A
authors.lastname: O'Connor
authors.forename: Emma
authors.initials: E
authors.lastname: Whitcomb
authors.forename: John
authors.initials: J
authors.lastname: Hart
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Gottlieb
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006073:Gout / Q000150:complications / Q000188:drug therapy; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D006074:Gout Suppressants; D000493:Allopurinol