title: Changes in foot function, disease activity, and disability after forefoot resection arthroplasty in patients with rheumatoid arthritis.
abstract: The purpose of this study was to investigate the changes in foot function, disease activity, and disability in patients with RA after resection arthroplasty of the forefoot (arthroplasty). Arthroplasty was performed on 11 patients with RA. All study patients underwent clinical assessment to measure disease activity (Disease Activity Score in 28 Joints-C-reactive protein, DAS28-CRP), disability (Health Assessment Questionnaire-Disability Index, HAQ-DI) and foot function (Foot Function Index, FFI) at the following stages: preoperatively and 1, 3, and 12 months after surgery. Following arthroplasty, foot function improved significantly, as assessed by FFI total and subscales (pain, disability, and limitation of activity) (P<0.001, P<0.001, P<0.001, and P=0.002, respectively). Disease activity was significantly improved in relation to DAS28-CRP and its subscales of number of swollen joints and patient global assessment (PtGA) (P=0.033, P=0.008, and P=0.038, respectively). There was no significant difference in disability, as assessed by the HAQ-DI and its subscale, HAQ-walking (P=0.150 and P=0.597, respectively). Foot function improved significantly after arthroplasty, and was maintained at 12 months postoperatively. Additionally, our study showed that disease activity and its subscale PtGA improved after arthroplasty.
authors.affiliation: Department of Preventive Medicine, Institute of Biomedical Sciences, the University of Tokushima Graduate School.
authors.forename: Fusakazu
authors.initials: F
authors.lastname: Sawachika
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Uemura
authors.forename: Sakurako
authors.initials: S
authors.lastname: Katsuura-Kamano
authors.forename: Miwa
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Tirani
authors.initials: T
authors.lastname: Bahari
authors.forename: Keisuke
authors.initials: K
authors.lastname: Miki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Todo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Inoo
authors.forename: Ikuko
authors.initials: I
authors.lastname: Onishi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kurata
authors.forename: Kokichi
authors.initials: K
authors.lastname: Arisawa
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D001178:Arthroplasty; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005545:Forefoot, Human / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D002097:C-Reactive Protein