title: Prophylaxis of venous thromboembolism in cancer patients.
abstract: Venous thromboembolism (VTE) is an independent prognostic factor and the second leading cause of death in cancer patients. VTE is however a largely preventable disease when thromboprophylaxis is appropriately used. As recommended worldwide by international Clinical Practice Guidelines, cancer patients undergoing surgery or hospitalization for acute medical illness or with reduced mobility should benefit from thromboprophylaxis, in the absence of bleeding or other contraindications to anticoagulants. Thromboprophylaxis in cancer outpatients receiving systemic therapies is still under debate, except for pancreatic ambulatory cancer patients where prophylaxis confers a sustained reduction in VTE. Numerous strategies are currently developed to improve VTE prophylaxis practices in cancer patients, and to elucidate the best appropriate anticoagulant regimen for each individual cancer patient.
authors.affiliation: a Assistance Publique Hôpitaux de Marseille, Timone Hospital, Service d'Hématologie biologique , Marseille , France.|b Aix-Marseille Université, INSERM UMRS 1076, VRCM , Marseille , France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Frere
authors.affiliation: c Oncology Department , Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital , Paris , France.|d Paris 7 Diderot University, Sorbonne Paris Cité , Paris , France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Doucet
authors.affiliation: e Unité de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire , Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital , Paris , France.|f INSERM UMRS 1160, Paris 7 Diderot University, Sorbonne Paris Cité , Paris , France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Farge
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D018890:Chemoprevention; D006801:Humans; D007297:Inpatients; D009369:Neoplasms / Q000150:complications*; D010045:Outpatients; D011292:Premedication; D058996:Quality Improvement; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants
keywords: Venous thromboembolism; anticoagulants; current clinical practice guidelines; prophylaxis; risk assessment