title: Proximity ligation-induced assembly of DNAzymes for simple and cost-effective colourimetric detection of proteins with high sensitivity.
abstract: A novel colourimetric method for protein assays is proposed based on proximity ligation induced assembly of Mg(2+)-dependent DNAzymes, which may offer simple, cost-effective, sensitive and selective detection of the target protein.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China. genxili@nju.edu.cn.
authors.forename: Luming
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China. genxili@nju.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China. genxili@nju.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China. genxili@nju.edu.cn and Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
authors.forename: Genxi
authors.initials: G
authors.lastname: Li
mesh_terms: D003124:Colorimetry; D003362:Cost-Benefit Analysis; D021881:DNA, Catalytic / Q000378:metabolism*; D057230:Limit of Detection; D011506:Proteins / Q000032:analysis*
chemical_list: D021881:DNA, Catalytic; D011506:Proteins