title: Choukroun Platelet-Rich Fibrin as an Autogenous Graft Biomaterial in Preimplant Surgery: Results of a Preliminary Randomized, Human Histomorphometric, Split-Mouth Study.
abstract: This study aimed to test the null hypothesis that platelet-rich fibrin (PRF), as an immediate postextraction graft material, produces bone that is histomorphometrically no different than bone derived from healing without intervention. The authors compared split-mouth human bone biopsy specimens derived from PRF with bone that had healed without intervention. Eight human bone biopsies were successfully harvested from four patients. The mean ± standard deviation (SD) percent of newly formed osteoid was 9.9% ± 5.9% for specimens derived from PRF, and 4% ± 2.1% for specimens derived from the control sites (P = .089; 95% confidence interval [CI] 4.5-18.1 and 1.6-6.6, respectively). Mean ± SD percent of new mineralized bone was 40.8% ± 10.3% for the PRF specimens and 43.9% ± 16.8% for the control specimens (P = .72, 95% CI, 33.4-55.6 and 19.3-55.5, respectively). Newly formed bone to fibrovascular tissue ratios for specimens in the PRF and control groups were 51%:49% and 48%:52%, respectively. Within the limitations of this study, the null hypothesis could not be rejected. Bone derived from PRF histologically did not differ from bone that healed without intervention.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Du Toit
authors.forename: Andreas
authors.initials: A
authors.lastname: Siebold
authors.forename: Andries
authors.initials: A
authors.lastname: Dreyer
authors.forename: Howard
authors.initials: H
authors.lastname: Gluckman
mesh_terms: D001672:Biocompatible Materials; D001792:Blood Platelets; D001861:Bone Regeneration; D005337:Fibrin; D006801:Humans; D009055:Mouth; D016348:Osseointegration; D014081:Tooth Extraction
chemical_list: D001672:Biocompatible Materials; D005337:Fibrin