title: Engineering virus-like particles as vaccine platforms.
abstract: Virus-like particles (VLPs) have been utilized as vaccine platforms to increase the immunogenicity of heterologous antigens. A variety of diverse VLP types can serve as vaccine platforms, and research has focused on engineering VLPs to improve their efficacy as vaccines, enhance their stability, and allow for more versatile display of antigens. Here, we review selected VLP vaccine platforms, highlight efforts to improve these platforms through structure-informed rational design, and point to areas of future research that will assist in these efforts.
authors.affiliation: Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico, United States.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Frietze
authors.affiliation: Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico, United States.
authors.forename: David S
authors.initials: DS
authors.lastname: Peabody
authors.affiliation: Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico, United States. Electronic address: bchackerian@salud.unm.edu.
authors.forename: Bryce
authors.initials: B
authors.lastname: Chackerian
mesh_terms: D000956:Antigens, Viral / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D005818:Genetic Engineering / Q000379:methods; D000071497:Immunogenicity, Vaccine; D058425:Vaccines, Virus-Like Particle / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D058425:Vaccines, Virus-Like Particle