title: Unsaturated Phosphonates as Hauser Acceptors for the Synthesis of Phosphonylated Dihydroxynaphthalenes and Naphthoquinones.
abstract: The unsaturated phosphonates were utilized as Hauser acceptors successfully for the first time. The products phosphonylated 1,4-dihydroxynaphthalenes were isolated in good yields in short reaction time and were further oxidized to the corresponding 1,4-naphthoquinones in quantitative yields. The reaction provides an efficient and straightforward approach for the synthesis of pharmacologically privileged disubstituted naphthalene-1,4-diols and naphtha-1,4-diones bearing a phosphonate group at the 2-position and various (het)aryl groups at the 3-position.
authors.affiliation: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute , B.S. 10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India.
authors.forename: Atul Kumar
authors.initials: AK
authors.lastname: Chaturvedi
authors.affiliation: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute , B.S. 10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India.
authors.forename: Namrata
authors.initials: N
authors.lastname: Rastogi