title: Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray.
abstract: One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be "turned on" and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. wangwz@nanoctr.cn huzy@nanoctr.cn and University of Chinese Academy of Science, No. 19A Yuquan Road, Beijing 100049, China and Sino-Danish Center for Education and Research, Beijing, 100190, China.
authors.forename: Yixia
authors.initials: Y
authors.lastname: Qian
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. wangwz@nanoctr.cn huzy@nanoctr.cn.
authors.forename: Weizhi
authors.initials: W
authors.lastname: Wang
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. wangwz@nanoctr.cn huzy@nanoctr.cn.
authors.forename: Zihua
authors.initials: Z
authors.lastname: Wang
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. wangwz@nanoctr.cn huzy@nanoctr.cn and Pharmacy College, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Qiuju
authors.initials: Q
authors.lastname: Han
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. wangwz@nanoctr.cn huzy@nanoctr.cn and Pharmacy College, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Jia
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. wangwz@nanoctr.cn huzy@nanoctr.cn.
authors.forename: Shu
authors.initials: S
authors.lastname: Yang
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. wangwz@nanoctr.cn huzy@nanoctr.cn.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Hu
mesh_terms: D006863:Hydrogen-Ion Concentration; D015335:Molecular Probes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000737:chemistry*
chemical_list: D015335:Molecular Probes; D010455:Peptides; D040301:Vascular Endothelial Growth Factor Receptor-2