title: Evaluating the effectiveness of localized control strategies to curtail chikungunya.
abstract: Chikungunya, a re-emerging arbovirus transmitted to humans by Aedes aegypti and Ae. albopictus mosquitoes, causes debilitating disease characterized by an acute febrile phase and chronic joint pain. Chikungunya has recently spread to the island of St. Martin and subsequently throughout the Americas. The disease is now affecting 42 countries and territories throughout the Americas. While chikungunya is mainly a tropical disease, the recent introduction and subsequent spread of Ae. albopictus into temperate regions has increased the threat of chikungunya outbreaks beyond the tropics. Given that there are currently no vaccines or treatments for chikungunya, vector control remains the primary measure to curtail transmission. To investigate the effectiveness of a containment strategy that combines disease surveillance, localized vector control and transmission reduction measures, we developed a model of chikungunya transmission dynamics within a large residential neighborhood, explicitly accounting for human and mosquito movement. Our findings indicate that prompt targeted vector control efforts combined with measures to reduce transmission from symptomatic cases to mosquitoes may be highly effective approaches for controlling outbreaks of chikungunya, provided that sufficient detection of chikungunya cases can be achieved.
authors.affiliation: Department of Epidemiology of Microbial Disease, Yale School of Public Health, New Haven, CT, USA.
authors.forename: Martial L
authors.initials: ML
authors.lastname: Ndeffo-Mbah
authors.affiliation: Department of Epidemiology of Microbial Disease, Yale School of Public Health, New Haven, CT, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Durham
authors.affiliation: Department of Epidemiology of Microbial Disease, Yale School of Public Health, New Haven, CT, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Skrip
authors.affiliation: Children's Hospital Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Elaine O
authors.initials: EO
authors.lastname: Nsoesie
authors.affiliation: Children's Hospital Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: John S
authors.initials: JS
authors.lastname: Brownstein
authors.affiliation: Department of Epidemiology of Microbial Disease, Yale School of Public Health, New Haven, CT, USA.
authors.forename: Durland
authors.initials: D
authors.lastname: Fish
authors.affiliation: Department of Epidemiology of Microbial Disease, Yale School of Public Health, New Haven, CT, USA.|Department of Ecology &Evolutionary Biology, Yale University, New Haven, CT, USA.
authors.forename: Alison P
authors.initials: AP
authors.lastname: Galvani
mesh_terms: D000330:Aedes / Q000821:virology; D000465:Algorithms; D000818:Animals; D065632:Chikungunya Fever / Q000517:prevention & control* / Q000635:transmission*; D002646:Chikungunya virus; D003140:Communicable Disease Control; D004196:Disease Outbreaks; D005843:Geography; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D009032:Mosquito Control; D015397:Program Evaluation; D012111:Residence Characteristics; D013020:South America; D014612:Vaccines
chemical_list: D014612:Vaccines