title: Vancomycin-induced thrombocytopenia: a rare adverse effect in a patient -submitted to bone graft in the jaw.
abstract: BACKGROUND
  Thrombocytopenia is the reduction in the number of blood -platelets, which may be caused by -several different conditions such as sepsis, disseminated intravascular -clotting, and large blood losses. Additionally, in rare situations, thrombocytopenia may also be induced by the use of medicaments. One of these drugs is the vancomycin, a glycopeptide presently used against -serious infections involving Gram-positive bacteria such as the methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus.
  
  
  OBJECTIVE
  The objective of this study is to report on a case of serious vancomycin-induced thrombocytopenia in a patient infected with methicillin-resistant S. aureus after mandibular reconstruction with autogenous bone graft, and to draw attention to the importance of this clinically rare adverse effect.
  
  
  CONCLUSIONS
  Vancomycin-induced thrombocytopenia is a rare condition, which is also a significant disorder that demands attention and the rapid identification and replacement of the antimicrobial agent.
authors.affiliation: Master Student, Implantodonty, Araçatuba Dentistry School, UNESP - Universidade Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Carolina Ferrairo
authors.initials: CF
authors.lastname: Danieletto
authors.affiliation: Professor, Dental Surgery, Department of Dentistry, UNICESUMAR - Cesumar University Center, Maringá, Paraná, Brazil.
authors.forename: Gustavo Zanna
authors.initials: GZ
authors.lastname: Ferreira
authors.affiliation: Associated Professor, Dental Surgery, State University of Maringá, Paraná, Brazil.
authors.forename: Gustavo Jacobucci
authors.initials: GJ
authors.lastname: Farah
authors.affiliation: Associated Professor, Pharmacology, State University of Maringá, Paraná, Brazil.
authors.forename: Roberto Kenji Nakamura
authors.initials: RK
authors.lastname: Cuman
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001860:Bone Plates; D001863:Bone Screws; D016025:Bone Transplantation; D005260:Female; D006801:Humans; D063175:Mandibular Reconstruction; D055624:Methicillin-Resistant Staphylococcus aureus; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013530:Surgical Wound Infection / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced*; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin
keywords: antibacterial; bone graft; thrombocytopenia; vancomycin