title: Hypertransaminasaemia in children with viral gastroenteritis.
abstract: We investigated the rates of increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels of patients with rotavirus, norovirus and enteric adenovirus gastroenteritis. Two hundred children with viral gastroenteritis were evaluated for hypertransaminasaemia retrospectively. The patients were between 0 - 17 years (mean ± SD: 5.10 ± 3.01) of age. ALT was elevated up to 67 IU/L in 7 (8.5%) patients in the rotavirus group (n=82), whereas it was elevated in 3 (4.0%) and 1 (2.3%) patients in the norovirus (n=74) and adenovirus (n=44) groups, respectively. AST was elevated up to 89 IU/L in 20 (24.4%) patients in the rotavirus group, whereas it was elevated in 6 (8.1%) and 1 (2.3%) patients in the norovirus and adenovirus groups, respectively. Both transaminases were elevated in 7.3%, 1.4%, and 2.3% of patients in the rotavirus, norovirus, and adenovirus groups, respectively. The increases in ALT and AST levels were found to be significantly higher in the rotavirus group (n=27) than in the norovirus (n=9), and adenovirus group (n=2) (p<0.05). Mean serum ALT and AST levels in the rotavirus group were significantly higher than those in the norovirus and adenovirus group (p<0.05). Our study investigated the correlation between viral gastroenteritis and hypertransaminasaemia. When evaluating a patient with hypertransaminasaemia physicians should remember to consider acute gastroenteritis due to some viruses as a cause of elevated AST and ALT.
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Oznur
authors.initials: O
authors.lastname: Kucuk
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Ugras
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Suat
authors.initials: S
authors.lastname: Bicer
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Defne
authors.initials: D
authors.lastname: Col
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Giray
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Gulay Ciler
authors.initials: GC
authors.lastname: Erdag
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Yalvaç
authors.affiliation: Department of Medical Statistics and Informatics, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Kaspar
authors.affiliation: Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Ayca
authors.initials: A
authors.lastname: Vitrinel
mesh_terms: D000256:Adenoviridae / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000150:complications; D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D017250:Caliciviridae Infections / Q000150:complications; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000097:blood / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D029322:Norovirus / Q000302:isolation & purification; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000150:complications* / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase