title: Canaloplasty in patients with uveitic glaucoma: a pilot study.
abstract: OBJECTIVE
  Glaucoma is a common vision-threatening complication of uveitis. We investigated the outcome of canaloplasty in patients with chronic uveitis and uncontrolled secondary glaucoma.
  
  
  METHODS
  This was a retrospective study of 12 patients with medically uncontrolled secondary glaucoma who underwent canaloplasty (14 treated eyes), with follow-up of ≥ 24 months. The primary outcome measure was complete and qualified (requirement for anti-glaucomatous medication) surgical success rates, as determined by a reduction in intraocular pressure (IOP) and the need for anti-glaucomatous medication. Secondary outcome measures were uveitis activity, best-corrected visual acuity (BCVA), vision-threatening complications, and secondary glaucoma surgery.
  
  
  RESULTS
  Canaloplasty resulted in a significant IOP reduction, from a mean preoperative baseline level of 27.1 ± 12.3 mmHg to a mean of 14.5 ± 4.3 mmHg (p = 0.01) at 24 months. Complete success (limit of 15 mmHg) was achieved in six patients and qualified success in one patient. However, failure was noted in five patients, two of whom required additional glaucoma surgery. Topical anti-glaucomatous medications were reduced from 2.7 ± 1.2 (mean ± SD) at baseline to 0.6 ± 1.2 at 24 months (p = 0.007). Uveitis activity did not increase after surgery. BCVA was not reduced; cataract progressed in two patients.
  
  
  CONCLUSIONS
  At 2-year follow-up, overall success rate was 58 % (IOP ≤ 15 with or without medication), and surgery failed in 5 eyes, 2 eyes requiring additional glaucoma surgery. No harmful complications or worsening of uveitis activity were noted.
authors.affiliation: Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany. claudia.lommatzsch@gmx.de.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lommatzsch
authors.affiliation: Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany.|University of Duisburg-Essen, Essen, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Heinz
authors.affiliation: Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany.|University of Duisburg-Essen, Essen, Germany.|Department of Experimental Ophthalmology, University of Muenster, Muenster, Germany.
authors.forename: Arnd
authors.initials: A
authors.lastname: Heiligenhaus
authors.affiliation: Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany.
authors.forename: Joerg Michael
authors.initials: JM
authors.lastname: Koch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D018463:Filtering Surgery / Q000379:methods; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008875:Middle Aged; D010865:Pilot Projects; D012189:Retrospective Studies; D013997:Time Factors; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis; D014792:Visual Acuity; D055815:Young Adult
keywords: Canaloplasty; Glaucoma; Intraocular pressure; Uveitis