title: Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.
abstract: BACKGROUND
  A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Metformin, a commonly used medication to improve glycemic control, has been reported to cause dermatologic reactions in some case reports, but only a single previously documented case report discusses the potential of metformin-associated FDE.
  
  
  METHODS
  We describe a 56-year-old woman who developed a FDE with multiple exposures to metformin. Upon each exposure, small, round, erythematic lesions developed on the palms of the hands and soles of the feet; these lesions resolved each time after discontinuation of metformin. According to the Naranjo scale, there is a definite association between metformin and FDE in this case (score of 8).
  
  
  CONCLUSIONS
  This report contributes to the limited documented literature on metformin-induced FDE. Clinicians should be made aware of possible FDEs associated with this commonly used medication.
authors.affiliation: Levine College of Health Sciences, Wingate University, Wingate, NC, USA.
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Steber
authors.affiliation: College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC, USA.
authors.forename: Scott L
authors.initials: SL
authors.lastname: Perkins
authors.affiliation: Levine College of Health Sciences, Wingate University, Wingate, NC, USA.
authors.forename: Kira B
authors.initials: KB
authors.lastname: Harris
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin