title: Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma.
abstract: Renal function influences decisions regarding treatment for patients with oropharyngeal squamous cell carcinoma (SCC). However, the importance of renal function in oropharyngeal SCC has not yet been reported.
  
  
  
  Four hundred sixty patients with oropharyngeal SCC treated with curative intent between April 2005 and March 2007 in 12 institutions in Japan were analyzed retrospectively.
  
  
  
  Four hundred three patients (87.6%) showed a creatinine clearance (CrCl) ≥50 mL/min and 57 (12.4%) with a CrCl <50 mL/min. Age was associated with worse overall survival (OS), whereas stage IVB, radiotherapy (RT), and CrCl <50 were associated with worse OS on univariate analyses. Surgery and hypertension were associated with better OS on univariate analyses. On multivariate analysis, age, stage, hypertension, and CrCl were also found to be significantly associated with OS.
  
  
  
  Based on this retrospective study, impaired renal function is an independent predictor of increased risk of death in patients with oropharyngeal SCC. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1500, 2016.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. ak-homma@med.hokudai.ac.jp.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Homma
authors.affiliation: Head and Neck Surgery Division, National Cancer Center Hospital East, Kashiwa, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hayashi
authors.affiliation: Department of Head and Neck Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawabata
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
authors.affiliation: Department of Head and Neck Surgery, Hyogo Cancer Center, Kobe, Japan.
authors.forename: Shigemichi
authors.initials: S
authors.lastname: Iwae
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Hasegawa
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nibu
authors.affiliation: Department of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Takakuni
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.|Department of Otolaryngology - Head and Neck Surgery, Iwate Medical University School of Medicine, Morioka, Japan.
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Shiga
authors.affiliation: Division of Head and Neck Surgery, Miyagi Cancer Center, Sendai, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Matsuura
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, National Shikoku Cancer Center, Matsuyama, Japan.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Monden
authors.affiliation: Department of Otorhinolaryngology, National Tokyo Medical Center, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000150:complications / Q000401:mortality; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
keywords: comorbidity; oropharyngeal cancer; prognosis; renal function; squamous cell carcinoma