title: Antiviral effect of resveratrol in ducklings infected with virulent duck enteritis virus.
abstract: Duck enteritis virus (DEV) is a double-stranded DNA virus belonging to the alphaherpesvirinae subfamily of the herpesviridae. Although vaccines were wildly used in controlling this disease, some infection could still not be prevented and led to significant economic losses as a result of mortality and decreased egg production. However, there is no antiviral drug against DEV. Resveratrol was identified to exert its antiviral activity by inhibiting the DEV replication in preliminary investigations. In the present study, we confirmed that resveratrol significantly reduced the mortality of ducklings which infected with a virulent strain of DEV. With resveratrol treatment, the survival rate increased by almost 80% at 8 days post infection (dpi). Pathological symptoms of ducklings caused by DEV were also relieved by resveratrol. The virus load in blood and tissues were effectively depressed when compared with the untreated group. In the assay of immune cytokines, the resveratrol exerted a dual-regulation effect. These results suggest that resveratrol is expected to be a new alternative control measure for DEV infection.
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Xinghong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China; Leshan Vocational & Technical College, Leshan 614000, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Xu
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Song
authors.affiliation: Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Ruilin
authors.initials: R
authors.lastname: Jia
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address: yinzhongq@163.com.
authors.forename: Zhongqiong
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China. Electronic address: chenganchun@vip.163.com.
authors.forename: Anchun
authors.initials: A
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Renyong
authors.initials: R
authors.lastname: Jia
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Yuanfeng
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Li
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Lizi
authors.initials: L
authors.lastname: Yin
authors.affiliation: College of Science, Sichuan Agricultural University, Ya'an 625014, China.
authors.forename: Guizhou
authors.initials: G
authors.lastname: Yue
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Lv
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jing
mesh_terms: D018138:Alphaherpesvirinae / Q000187:drug effects* / Q000472:pathogenicity; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood; D004372:Ducks; D006566:Herpesviridae Infections / Q000662:veterinary*; D011201:Poultry Diseases / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000821:virology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D013267:Stilbenes; D000077185:Resveratrol
keywords: Antiviral activity; Duck enteritis virus; Resveratrol