title: Learning from the "tsunami" of immune checkpoint inhibitors in 2015.
abstract: 2015 was marked by the tsunami of immune checkpoint inhibitors revealed by numerous FDA approvals, publications and abstracts in relation with these drugs in different cancers and settings. First, we reported all new indications of anti-CTLA4 and anti-PD1 approved by the FDA, the positive clinical trials published and the abstracts with promising results at important scientific meetings during 2015. Then, we discussed different critical issues of these new agents going from their predictive factors, combination therapies, tumor response patterns, efficacy in particular settings, side effect management to cost and economic burden.
authors.affiliation: Medical oncology clinic, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: hampig.kourie@hotmail.com.
authors.forename: Hampig Raphael
authors.initials: HR
authors.lastname: Kourie
authors.affiliation: Internal medicine, Vrije Universiteit Brussels, Belgium.
authors.forename: Gil
authors.initials: G
authors.lastname: Awada
authors.affiliation: Medical oncology clinic, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Ahmad Hussein
authors.initials: AH
authors.lastname: Awada
mesh_terms: D003131:Combined Modality Therapy; D017281:Cost of Illness; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000191:economics / Q000628:therapy
keywords: 2015; Cancer; Immune checkpoint inhibitors; Round up; Treatment