title: Serum complement C3 levels are associated with nonalcoholic fatty liver disease independently of metabolic features in Chinese population.
abstract: Serum complement C3 levels are closely associated with obesity and related metabolic disorders. This study aimed to investigate the association between serum complement C3 levels with non-alcoholic fatty liver disease (NAFLD). A cross-sectional study was performed among adults who took their annual health examinations at Zhenhai Lianhua Hospital, Ningbo, China during 2014. We included 7540 participants (5069 men and 2471 women) in this study. NAFLD patients had higher serum complement C3 levels (P < 0.001), and these levels were positively associated with both NAFLD prevalence and severity (P < 0.001). The above association remains true among lean and metabolic syndrome-free participants. Multivariable regression analysis showed that serum complement C3 was independently associated with risk for NAFLD (OR = 5.231; 95% CI: 3.169-8.635). Serum complement C3 level is positively associated with prevalence and severity of NAFLD, and this association is independent of obesity and metabolic syndrome.
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Chengfu
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.|Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Internal Medicine, Zhenhai Lianhua Hospital, Ningbo, China.
authors.forename: Min
authors.initials: M
authors.lastname: Miao
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Youming
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Chaohui
authors.initials: C
authors.lastname: Yu
mesh_terms: D000328:Adult; D002681:China; D003176:Complement C3 / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000473:pathology; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D009765:Obesity / Q000473:pathology; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D003176:Complement C3