title: miR-429 functions as a tumor suppressor by targeting FSCN1 in gastric cancer cells.
abstract: It has been previously reported that the deregulation of microRNAs in gastric cancer (GC) was correlated with the progression and prognosis. miR-429, a member of the miR-200 family, was previously shown to play an important role in human carcinomas. Our study shows that miR-429 is significantly downregulated in GC tissues compared with matched nontumor tissues. Overexpression of miR-429 in GC cells suppressed cell proliferation. Fascin-1 (FSCN1) was identified as one of the targets of miR-429 and knockdown of FSCN1 mimics the function of miR-429 overexpression. In conclusion, miR-429 acts as a tumor suppressor by targeting FSCN1, suggesting that miR-429 and FSCN1 can both be potential therapeutic targets of GC.
authors.affiliation: Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
authors.forename: Bing-Bin
authors.initials: BB
authors.lastname: Dong
authors.affiliation: Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.affiliation: Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Zheng
authors.affiliation: Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
authors.forename: He
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA, USA.
authors.forename: Jing-Zhen
authors.initials: JZ
authors.lastname: Ding
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
authors.forename: A-Man
authors.initials: AM
authors.lastname: Xu
authors.affiliation: Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
authors.forename: Yuan-Hong
authors.initials: YH
authors.lastname: Xu
keywords: FSCN1; gastric cancer; miR-429; proliferation