title: Rationale and design for an investigation to optimize selective serotonin reuptake inhibitor treatment for pregnant women with depression.
abstract: The physiological changes of pregnancy can affect the pharmacokinetics of a drug, thereby affecting its dose requirements. Because pharmacokinetic (PK) studies in pregnant women have rarely been conducted, evidence-based dosing adjustments are seldom available. In particular, despite the fact that the use of antidepressants has become increasingly common, pregnancy-associated PK changes of the selective serotonin reuptake inhibitors (SSRIs) are largely unknown.
authors.affiliation: Northwestern University Feinberg School of Medicine, Department of Anesthesiology, Chicago, Illinois, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Avram
authors.affiliation: Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, Chicago, Illinois, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Stika
authors.affiliation: Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, Chicago, Illinois, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Rasmussen-Torvik
authors.affiliation: Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, Chicago, Illinois, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Ciolino
authors.affiliation: Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, Illinois, USA.
authors.forename: E
authors.initials: E
authors.lastname: Pinheiro
authors.affiliation: Northwestern University Feinberg School of Medicine, Department of Pharmacology, Chicago, Illinois, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: George
authors.affiliation: Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, Illinois, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Wisner
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012107:Research Design; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors