title: A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells.
abstract: A series of 2,3-diarylindoles were synthesized via the Larock heteroannulation, and evaluated for their anticancer activity against A549 lung cancer cells. The most potent compound, PCNT13 with IC50=5.17 μM, caused the induction of two modes of programmed cell death, apoptosis and autophagy.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, and Special Research Unit for Advanced Magnetic Resonance (AMR), Kasetsart University, Bangkok 10900, Thailand.
authors.forename: Thanya
authors.initials: T
authors.lastname: Rukkijakan
authors.affiliation: Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand. Electronic address: lukana@cri.or.th.
authors.forename: Lukana
authors.initials: L
authors.lastname: Ngiwsara
authors.affiliation: Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand.
authors.forename: Kriengsak
authors.initials: K
authors.lastname: Lirdprapamongkol
authors.affiliation: Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand.
authors.forename: Jisnuson
authors.initials: J
authors.lastname: Svasti
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, and Special Research Unit for Advanced Magnetic Resonance (AMR), Kasetsart University, Bangkok 10900, Thailand.
authors.forename: Nared
authors.initials: N
authors.lastname: Phetrak
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, and Special Research Unit for Advanced Magnetic Resonance (AMR), Kasetsart University, Bangkok 10900, Thailand. Electronic address: Pitak.C@ku.ac.th.
authors.forename: Pitak
authors.initials: P
authors.lastname: Chuawong
mesh_terms: D000072283:A549 Cells; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001343:Autophagy / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D018942:Macrolides; C000621057:PCNT13; C040929:bafilomycin A1
keywords: 2,3-Diarylindole; Apoptosis; Autophagy; Lung cancer