title: Khat-induced liver injuries: A report of two cases.
abstract: Khat is consumed for recreational purposes in many countries, including Yemen, where >50% of adults chew khat leaves regularly. A wide spectrum of khat-induced liver injuries has been reported in the literature. Herein, we report two patients with khat-induced liver injury. Both patients clinically presented with acute hepatitis, one of whom showed radiological evidence of hepatic outflow obstruction. Based on the histological tests, both patients had acute hepatitis, which indicated drug-induced liver injury (DILI) on a background of chronic hepatitis and portal fibrosis; of the two, one presented with symptoms of immune-mediated liver injury.
authors.affiliation: Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: dromkolsoum@yahoo.com.
authors.forename: Omkolsoum M
authors.initials: OM
authors.lastname: Alhaddad
authors.affiliation: Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: maha.ahmed@liver.menofia.edu.eg.
authors.forename: Maha M
authors.initials: MM
authors.lastname: Elsabaawy
authors.affiliation: Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: emanrewisha@yahoo.com.
authors.forename: Eman A
authors.initials: EA
authors.lastname: Rewisha
authors.affiliation: Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: tarysalman@yahoo.com.
authors.forename: Tary A
authors.initials: TA
authors.lastname: Salman
authors.affiliation: Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: dr_mohamedsamy@yahoo.com.
authors.forename: Mohamed A S
authors.initials: MA
authors.lastname: Kohla
authors.affiliation: Department of Pathology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: nermine_ehsan@yahoo.com.
authors.forename: Nermine A
authors.initials: NA
authors.lastname: Ehsan
authors.affiliation: Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: iwaked@liver-eg.org.
authors.forename: Imam A
authors.initials: IA
authors.lastname: Waked
mesh_terms: D000328:Adult; D029754:Catha / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006505:Hepatitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D018515:Plant Leaves; D028321:Plant Preparations / Q000009:adverse effects*
chemical_list: D028321:Plant Preparations
keywords: Induced; Injury; Khat; Liver