title: Sensitivity of MRI parameters within intervertebral discs to the severity of adolescent idiopathic scoliosis.
abstract: To measure magnetic resonance imaging (MRI) parameters including relaxation times (T1ρ, T2), magnetization transfer (MT) and diffusion parameters (mean diffusivity [MD], fractional anisotropy [FA]) of intervertebral discs in adolescents with idiopathic scoliosis, and to investigate the sensitivity of these MR parameters to the severity of the spine deformities.
  
  
  
  Thirteen patients with adolescent idiopathic scoliosis and three control volunteers with no history of spine disease underwent an MRI acquisition at 3T including the mapping of T1ρ, T2, MT, MD, and FA. The apical zone included all discs within the scoliotic curve while the control zone was composed of other discs. The severity was analyzed through low (<32°) versus high (>40°) Cobb angles. One-way analysis of variance (ANOVA) and agglomerative hierarchical clustering (AHC) were performed.
  
  
  
  Significant differences were found between the apical zone and the control zone for T2(P = 0.047), and between low and high Cobb angles for T2(P = 0.014) and MT (P = 0.002). AHC showed two distinct clusters, one with mainly low Cobb angles and one with mainly high Cobb angles, for the MRI parameters measured within the apical zone, with an accuracy of 0.9 and a Matthews correlation coefficient (MCC) of 0.8. Within the control zone, the AHC showed no clear classification (accuracy of 0.6 and MCC of 0.2).
  
  
  
  We successfully performed an in vivo multiparametric MRI investigation of young patients with adolescent idiopathic scoliosis. The MRI parameters measured within the intervertebral discs were found to be sensitive to intervertebral disc degeneration occurring with scoliosis and to the severity of scoliosis. J. Magn. Reson. Imaging 2016;44:1123-1131.
authors.affiliation: École Polytechnique de Montréal, Montreal, Quebec, Canada.|Research Center, CHU Ste-Justine, Montreal, Quebec, Canada.
authors.forename: Maxime
authors.initials: M
authors.lastname: Huber
authors.affiliation: Philips Healthcare, Montreal, Quebec, Canada.|CHUM Notre-Dame, Montreal, Quebec, Canada.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Gilbert
authors.affiliation: École Polytechnique de Montréal, Montreal, Quebec, Canada.|Research Center, CHU Ste-Justine, Montreal, Quebec, Canada.
authors.forename: Julien
authors.initials: J
authors.lastname: Roy
authors.affiliation: Research Center, CHU Ste-Justine, Montreal, Quebec, Canada.
authors.forename: Stefan
authors.initials: S
authors.lastname: Parent
authors.affiliation: Research Center, CHU Ste-Justine, Montreal, Quebec, Canada.
authors.forename: Hubert
authors.initials: H
authors.lastname: Labelle
authors.affiliation: École Polytechnique de Montréal, Montreal, Quebec, Canada. delphine.perie@polymtl.ca.|Research Center, CHU Ste-Justine, Montreal, Quebec, Canada. delphine.perie@polymtl.ca.|CHUM Notre-Dame, Montreal, Quebec, Canada. delphine.perie@polymtl.ca.
authors.forename: Delphine
authors.initials: D
authors.lastname: Périé
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007403:Intervertebral Disc / Q000000981:diagnostic imaging* / Q000473:pathology*; D055959:Intervertebral Disc Degeneration / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012600:Scoliosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Cobb angles; adolescent idiopathic scoliosis; degenerescence; in vivo; intervertebral disc; multiparametric MRI; severity