title: A New Approach to the Treatment of Uncomplicated Cystitis: Results of a Randomized Placebo-Controlled Clinical Trial.
abstract: OBJECTIVE
  To assess the efficacy and safety of a new medical device (MD; a capsule whose main component is a cross-linked protein) in the prevention of uncomplicated cystitis recurrences.
  
  
  METHODS
  Adult women with acute cystitis symptoms and a ciprofloxacin-susceptible isolate in urine culture were included in a randomized, double-blind clinical trial. Patients were treated with ciprofloxacin 500 mg/day and 1 capsule/day or matched placebo for 5 days, 1 capsule/day or placebo for 15 additional days, and 2 additional cycles of 1 capsule/day or placebo for 15 days on months 1 and 2 after initial treatment.
  
  
  RESULTS
  No recurrence was observed after the first month of follow-up in the MD-treated group. In addition, symptomatic recurrence was reduced by 19.4% compared with placebo after 6 months.
  
  
  CONCLUSIONS
  The new MD can help prevent the recurrence of uncomplicated cystitis as well as help to reduce antibiotic use in management of urinary tract infection in women.
authors.affiliation: General Practitioner, Local Health Agency of Pescara, Pescara, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Salvatorelli
authors.forename: Alejandro
authors.initials: A
authors.lastname: García-Larrosa
authors.forename: Alessandro
authors.initials: A
authors.lastname: Allegrini
authors.forename: Daniele
authors.initials: D
authors.lastname: Pavone
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002214:Capsules; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003556:Cystitis / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D010936:Plant Extracts / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002214:Capsules; D004338:Drug Combinations; D010936:Plant Extracts; D011134:Polysaccharides; C000617212:Utipro; D002939:Ciprofloxacin