title: A case of renal recovery in atypical hemolytic uremic syndrome treated with eculizumab.
abstract: Atypical Hemolytic Uremic Syndrome (aHUS) is a rare, life-threatening disease that can occur at any age and be sporadic or familial. aHUS is caused by an uncontrolled activation of the complement system. Plasma Exchange (PE) has been the standard treatment for years with poor results, leading approximately 40% of patients to end-stage renal disease (ESRD) or death during the first clinical manifestation. Eculizumab, an humanized monoclonal antibody directed against complement component C5, has emerged in the last few years as a new therapheutic aproach with promising results. Our goal is to present a case of an adult patient where eculizumab was sucessfully used as upfront therapy avoiding the potential significant morbidity of PE.
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: João Samuel de Holanda
authors.initials: JS
authors.lastname: Farias
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: João Pedro Pereira da
authors.initials: JP
authors.lastname: Cunha
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Caio Cesar Cervi
authors.initials: CC
authors.lastname: Lagana
authors.affiliation: Pontifícia Universidade Católica do Paraná, Brazil.
authors.forename: Maíra Carvalho
authors.initials: MC
authors.lastname: Gallucci
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Domingos Candiota
authors.initials: DC
authors.lastname: Chula
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Soares
authors.affiliation: Universidade Federal do Paraná, Brazil.
authors.forename: Marcelo Mazza
authors.initials: MM
authors.lastname: Nascimento
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D065766:Atypical Hemolytic Uremic Syndrome / Q000188:drug therapy*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D010951:Plasma Exchange
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C481642:eculizumab