title: Adipose regeneration and implications for breast reconstruction: update and the future.
abstract: The evolution of breast reconstruction and management of breast cancer has evolved significantly since the earliest descriptions in the Edwin Smith Papyrus (3,000 BC). The development of surgical and scientific expertise has changed the way that women are managed, and plastic surgeons are now able to offer a wide range of reconstructive options to suit individual needs. Beyond the gold standard autologous flap based reconstructions, regenerative therapies promise the elimination of donor site morbidity whilst providing equivalent aesthetic and functional outcomes. Future research aims to address questions regarding ideal cell source, optimisation of scaffold composition and interaction of de novo adipose tissue in the microenvironment of breast cancer.
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Emman J
authors.initials: EJ
authors.lastname: Combellack
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Zita M
authors.initials: ZM
authors.lastname: Jessop
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Naderi
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Griffin
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dobbs
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Amel
authors.initials: A
authors.lastname: Ibrahim
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Evans
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Burnell
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Shareen H
authors.initials: SH
authors.lastname: Doak
authors.affiliation: 1 Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Science, Swansea University, Swansea, UK ; 2 Burns & Plastic Surgery Department, Morriston Hospital, Swansea, UK ; 3 UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Iain S
authors.initials: IS
authors.lastname: Whitaker
keywords: Adipose derived stem cell (ADSC); adipose; breast reconstruction; regenerative medicine