title: [THE BIOMARKERS FOR TIMELY DIAGNOSTICS OF COLORECTAL CANCER].
abstract: The colorectal cancer (CC) is one of the most widespread type of cancer all over the world. It is confirmed that the screening procedures intended for timely detection of CC and adenomatous polyps, significantly decrease mortality. The colonoscopy and analysis offeces for occult blood are widely applied as screening procedures. However, they have a number of shortcomings. The studies of the last decade revealed number of genetic and epigenetic markers potentially permitting revealing patients with CC at early stages of development of disease. The article analyzes CC-specific microRNA and their possible interactions with different transcriptional factors. These factors, being integrated into the structure of so called network s with direct signal propagation, ensure special stability of all regulatory system. The derangement of functioning of these networks quite often results in pathological alterations.
authors.forename: E A
authors.initials: EA
authors.lastname: Sokolova
authors.forename: U A
authors.initials: UA
authors.lastname: Boyarskikh
authors.forename: A N
authors.initials: AN
authors.lastname: Shirshova
authors.forename: A E
authors.initials: AE
authors.lastname: Kel
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D018256:Adenomatous Polyps / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D042241:Early Diagnosis; D005243:Feces / Q000737:chemistry; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008403:Mass Screening; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009780:Occult Blood; D011933:Reagent Kits, Diagnostic; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C524940:MIRN21 microRNA, human; C541874:MIRN92 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; D011933:Reagent Kits, Diagnostic; D014157:Transcription Factors