title: Leukocyte Infiltration Triggers Seizure Recurrence in a Rat Model of Temporal Lobe Epilepsy.
abstract: Epilepsy, which affects about 1 % of the population worldwide, leads to poor prognosis and increased morbidity. However, effective drugs providing satisfactory control on seizure relapse were rare, which encouraged more etiological studies. Whether inflammation is one of key events underlying seizure is in debate. In order to explore the role of inflammatory in the pathogenesis and development of epilepsy, we conducted intra-caudal vein injection of leukocytes to aggravated brain inflammatory process in kainic acid-induced seizure model in this study. The results showed that intravenous administration of activated leukocytes increased the frequency and reduced the latent phase of seizure recurrences in rat models of epileptic seizure, during which leukocyte inflammation, brain-blood barrier damage, and neuron injury were also significantly aggravated, indicating that leukocyte infiltration might facilitate seizure recurrence through aggravating brain inflammation, brain-blood barrier damage, and neuron injury.
authors.affiliation: Department of Neurology, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian, China.
authors.forename: Zanhua
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurology, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian, China.
authors.forename: Suping
authors.initials: S
authors.lastname: Wang
authors.affiliation: NO.2 VIP ward, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian, China.
authors.forename: Jinjie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, The Shanghai First People's Hospital affiliated to Shanghai JiaoTong University, 85 Wujin Road, Shanghai, 200080, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurology, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, The Shanghai First People's Hospital affiliated to Shanghai JiaoTong University, 85 Wujin Road, Shanghai, 200080, People's Republic of China. zhaoyongbo2014@sina.com.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000293:injuries; D001921:Brain / Q000473:pathology; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000209:etiology*; D007249:Inflammation; D007608:Kainic Acid / Q000494:pharmacology; D007962:Leukocytes / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D051381:Rats; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced / Q000209:etiology*
chemical_list: D007608:Kainic Acid
keywords: brain–blood barrier; epilepsy; inflammation; leukocyte infiltration; seizure recurrence