title: Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States.
abstract: Quadrivalent human papillomavirus (4vHPV) vaccine was licensed for use in the United States in 2006 and through 2015 was the predominate HPV vaccine used. With the exception of syncope, a known preventable adverse event after any injected vaccination, both pre-licensure and post-licensure 4vHPV safety data have been reassuring with no confirmed safety signals identified. Nine-valent HPV vaccine (9vHPV) was licensed in 2014. This review includes post-licensure 4vHPV safety findings published to date that have informed the US vaccination program; these data will inform US safety monitoring and evaluation for 9vHPV.
authors.affiliation: a Division of Healthcare and Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.
authors.forename: Julianne
authors.initials: J
authors.lastname: Gee
authors.affiliation: a Division of Healthcare and Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Weinbaum
authors.affiliation: a Division of Healthcare and Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Sukumaran
authors.affiliation: b Division of Viral Diseases, National Center Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.
authors.forename: Lauri E
authors.initials: LE
authors.lastname: Markowitz
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D062665:Epidemiological Monitoring; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D013575:Syncope / Q000139:chemically induced / Q000453:epidemiology; D014481:United States
chemical_list: D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18