title: Physical Activity Frequency on the 10-Year Acute Coronary Syndrome (ACS) Prognosis; The Interaction With Cardiovascular Disease History and Diabetes Mellitus: The GREECS Observational Study.
abstract: The association between physical activity, diabetes mellitus (DM), and long-term acute coronary syndrome (ACS) prognosis was evaluated. The GREECS study included 2,172 consecutive ACS patients from six Greek hospitals (2003-2004). In 2013-2014, a 10-year follow up was performed with 1,918 patients. Physical activity was categorized in never, rarely (monthly basis), 1-2 and ≥ 3 times/week. Multi-adjusted analysis revealed that 1-2 and ≥ 3 times/week vs. no physical activity had a protective effect on ACS incidence (OR = 0.63 95% CI 0.38, 1.05) and (OR = 0.63 95% CI 0.40, 0.99) respectively, only in patients without prior baseline CVD event. In a subgroup analysis, with DM as strata in these patients, engagement in physical activity (i.e., 1-2 times/week) had a significant protective effect among patients with diabetes (OR = 0.51, 95% CI 0.27, 0.96, p = .037). These findings revealed the beneficial role of exercise in secondary ACS prevention, even in DM patients. Public health-oriented policies should incorporate regular physical activity as a key protective factor in disease prognosis.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Papataxiarchis
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: Venetia
authors.initials: V
authors.lastname: Notara
authors.forename: Matina
authors.initials: M
authors.lastname: Kouvari
authors.forename: Yannis
authors.initials: Y
authors.lastname: Kogias
authors.forename: Petros
authors.initials: P
authors.lastname: Stravopodis
authors.forename: George
authors.initials: G
authors.lastname: Papanagnou
authors.forename: Spyros
authors.initials: S
authors.lastname: Zombolos
authors.forename: Yannis
authors.initials: Y
authors.lastname: Mantas
authors.forename: Christos
authors.initials: C
authors.lastname: Pitsavos
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000517:prevention & control*; D000368:Aged; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000503:physiopathology*; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies
keywords: acute coronary syndrome; coronary heart disease history; diabetes mellitus; physical activity