title: In Vivo Visualization of Prostate-Specific Membrane Antigen in Adenoid Cystic Carcinoma of the Salivary Gland.
abstract: As the prostate-specific membrane antigen (PSMA) is overexpressed in the neovasculature of several malignancies, it might serve as a target in oncology. Ga-PSMA PET/CT and PET/MRI were performed in a female who developed pulmonary metastases from an adenoid cystic carcinoma of the right sublingual salivary gland after incomplete resection of the primary tumor and radiotherapy. Uptake of Ga-PSMA in tumors was observed, indicating PSMA expression. Moreover, a new cerebral metastasis was detected. Potentially, Ga-PSMA PET might be used for noninvasive assessment of adenoid cystic carcinoma to evaluate whether patients apply for PSMA-based radiotherapy when no further treatment options are available.
authors.affiliation: From the *Clinic for Nuclear Medicine, †BNCTeam, Department for Radiation-Oncology, and ‡Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Lütje
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sauerwein
authors.forename: Thomas
authors.initials: T
authors.lastname: Lauenstein
authors.forename: Andreas
authors.initials: A
authors.lastname: Bockisch
authors.forename: Thorsten D
authors.initials: TD
authors.lastname: Poeppel
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000000981:diagnostic imaging* / Q000556:secondary; D004492:Edetic Acid / Q000031:analogs & derivatives; D005260:Female; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D064847:Multimodal Imaging; D009842:Oligopeptides; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D013362:Sublingual Gland Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid