title: Normal Brain-Skull Development with Hybrid Deformable VR Models Simulation.
abstract: This paper describes a simulation framework for a clinical application involving skull-brain co-development in infants, leading to a platform for craniosynostosis modeling. Craniosynostosis occurs when one or more sutures are fused early in life, resulting in an abnormal skull shape. Surgery is required to reopen the suture and reduce intracranial pressure, but is difficult without any predictive model to assist surgical planning. We aim to study normal brain-skull growth by computer simulation, which requires a head model and appropriate mathematical methods for brain and skull growth respectively. On the basis of our previous model, we further specified suture model into fibrous and cartilaginous sutures and develop algorithm for skull extension. We evaluate the resulting simulation by comparison with datasets of cases and normal growth.
authors.affiliation: Biomedical Engineering, Western University, London, Ontario, Canada.
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.affiliation: Biomedical Engineering, Western University, London, Ontario, Canada.
authors.forename: Sandrine
authors.initials: S
authors.lastname: De Ribaupierre
authors.affiliation: Biomedical Engineering, Western University, London, Ontario, Canada.
authors.forename: Roy
authors.initials: R
authors.lastname: Eagleson
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000473:pathology / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D003196:Computer Graphics; D003198:Computer Simulation; D003398:Craniosynostoses; D055119:Elastic Modulus / Q000502:physiology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008954:Models, Biological; D012886:Skull / Q000033:anatomy & histology* / Q000254:growth & development*; D014584:User-Computer Interface; D055815:Young Adult