title: [Diagnostic analysis for 52 cases of gastrointestinal neuroendocrine tumor].
abstract: OBJECTIVE
  To investigate the clinical features, diagnosis, treatments and prognosis for gastrointestinal neuroendocrine tumors (GI-NETs).
  
  
  METHODS
  Clincal data of 52 patients, who were diagnosed as GI-NETs between January 2004 and October 2014, were reviewed. The patients were divided into a local excision group (n=21) and a transabdominal excision group (n=30), and the major clinical features, treatment modalities and outcomes were analyzed.
  
  
  RESULTS
  The clinical features of GI-NETs were nonspecific, and most of the clinical manifestation were local invasiveness. CT scan was lack of specific findings. GI-NETs greater than 1 cm often showed local incrassation, upheaval and soft tissue shadow. In the case of lager GI-NETs, necrosis and moderate enhancement could be seen. Positive ratio for expression of chromogranin A (CgA) and synaptophysin (Syn) in the 52 cases of specimen were 63.5% and 88.5%, respectively. Except 1 patient, whose surgery was canceled because of poor health, other 51 patients were treated with surgery through different approaches. Among them, 30 cases were transabdominal resection (57.7%) and 21 were local resection (40.4%). Chemotherapy and/or radiotherapy was only applied for 7 patients. After a follow-up of 40 (3-132) months, 7 patients died, the rest were alive. The median survival in the local resection group and the transabdominal resection group was 43.0 and 39.5 months, respectively (P>0.05).
  
  
  CONCLUSIONS
  Under the condition of fully understanding the biological characteristics of GI-NETs, early diagnosis and timely personalized treatment is hopeful to reach the relative good prognosis and survival.
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Yi'nan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Heli
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Pei
mesh_terms: D053379:Chromogranin A; D005770:Gastrointestinal Neoplasms; D006801:Humans; D018358:Neuroendocrine Tumors; D011379:Prognosis
chemical_list: D053379:Chromogranin A