title: Tandem Rh-catalysis: decarboxylative β-keto acid and alkyne cross-coupling.
abstract: Herein, we describe a regioselective Rh-catalyzed decarboxylative cross-coupling of β-keto acids and alkynes to access branched γ,δ-unsaturated ketones. Rh-hydride catalysis enables the isomerization of an alkyne to generate a metal-allyl species that can undergo carbon-carbon bond formation. Ketones are generated under mild conditions, without the need for base or activated electrophiles.
authors.affiliation: Department of Chemistry, University of California, Irvine, 4403 Natural Sciences 1, Irvine, California 92697, USA. dongv@uci.edu.
authors.forename: Faben A
authors.initials: FA
authors.lastname: Cruz
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Chen
authors.forename: Sarah I
authors.initials: SI
authors.lastname: Kurtoic
authors.forename: Vy M
authors.initials: VM
authors.lastname: Dong
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D007651:Keto Acids / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis*; D008956:Models, Chemical; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007651:Keto Acids; D007659:Ketones; D012238:Rhodium