title: Novel bat adenoviruses with an extremely large E3 gene.
abstract: Bats carry diverse RNA viruses, some of which are responsible for human diseases. Compared to bat-borne RNA viruses, relatively little information is known regarding bat-borne DNA viruses. In this study, we isolated and characterized three novel bat adenoviruses (BtAdV WIV9-11) from Rhinolophus sinicus. Their genomes, which are highly similar to each other but distinct from those of previously sequenced adenoviruses (AdVs), are 37 545, 37 566 and 38 073 bp in size, respectively. An unusually large E3 gene was identified in their genomes. Phylogenetic and taxonomic analyses suggested that these isolates represent a distinct species of the genus Mastadenovirus. Cell susceptibility assays revealed a broad cell tropism for these isolates, indicating that they have a potentially wide host range. Our results expand the understanding of genetic diversity of bat AdVs.
authors.affiliation: Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Tan
authors.affiliation: Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Xing-Lou
authors.initials: XL
authors.lastname: Yang
authors.affiliation: Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Xing-Yi
authors.initials: XY
authors.lastname: Ge
authors.affiliation: Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Yunnan Institute of Endemic Diseases Control and Prevention, Dali, China.
authors.forename: Yun-Zhi
authors.initials: YZ
authors.lastname: Zhang
authors.affiliation: Guangdong Entomological Institute, Guangzhou, China.
authors.forename: Li-Biao
authors.initials: LB
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Zheng-Li
authors.initials: ZL
authors.lastname: Shi
mesh_terms: D017503:Adenovirus E3 Proteins / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D036022:Capsid Proteins / Q000235:genetics; D002685:Chiroptera / Q000821:virology*; D002522:Chlorocebus aethiops; D006224:Cricetinae; D004279:DNA, Viral / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D016679:Genome, Viral / Q000235:genetics*; D058507:Host Specificity; D006801:Humans; D008253:Macaca mulatta; D017921:Mastadenovirus / Q000145:classification* / Q000235:genetics*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013552:Swine; D056189:Viral Tropism
chemical_list: D017503:Adenovirus E3 Proteins; D036022:Capsid Proteins; D004279:DNA, Viral; C018315:hexon capsid protein, Adenovirus