title: Prospective evaluation of Doppler echocardiography, tissue Doppler imaging and biomarkers measurement for the detection of doxorubicin-induced cardiotoxicity in dogs: A pilot study.
abstract: The purpose of this pilot study was to evaluate the usefulness of selected echocardiographic parameters, NT-proBNP and cardiac troponin I (cTnI) in the detection of cardiotoxicity in dogs treated with doxorubicin for various malignancies. Echocardiographic studies and biomarker measurements were performed before each administration of doxorubicin, then 1 and 3 months after completion of therapy. Thirteen dogs were included, with a total cumulative dose of doxorubicin ranging from 30 to 150 mg/m(2). E/A ratio significantly decreased during doxorubicin administration (p=0.047). cTnI level was also significantly affected by treatment (p=0.046), increasing above normal at least at one time point in 11 of 13 dogs. The results of this pilot study suggest that monitoring of left ventricular diastolic function and cTnI level measurement might be useful in the early detection of cardiotoxic signs of doxorubicin therapy in dogs.
authors.affiliation: Clinique Vétérinaire Olliolis, Ollioules, France. Electronic address: gallay@olliolis.com.
authors.forename: J
authors.initials: J
authors.lastname: Gallay-Lepoutre
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
authors.forename: M C
authors.initials: MC
authors.lastname: Bélanger
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
authors.forename: M E
authors.initials: ME
authors.lastname: Nadeau
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D066126:Cardiotoxicity / Q000175:diagnosis / Q000662:veterinary*; D003971:Diastole; D004285:Dogs; D004317:Doxorubicin / Q000633:toxicity*; D015150:Echocardiography, Doppler / Q000379:methods / Q000662:veterinary*; D005260:Female; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009369:Neoplasms / Q000188:drug therapy; D010446:Peptide Fragments / Q000097:blood*; D010865:Pilot Projects; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*; D016277:Ventricular Function, Left
chemical_list: D000903:Antibiotics, Antineoplastic; D015415:Biomarkers; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D004317:Doxorubicin
keywords: Biomarkers; Cardiotoxicity; Dog; Doppler echocardiography; Doxorubicin