title: Influences of Fucoxanthin on Alveolar Bone Resorption in Induced Periodontitis in Rat Molars.
abstract: The aim of this study was to evaluate the effects of systemic fucoxanthin treatment on alveolar bone resorption in rats with periodontitis. Thirty rats were divided into control, experimental periodontitis (EP), and experimental periodontitis-fucoxanthin (EP-FUCO) groups. Periodontitis was induced by ligature for four weeks. After removal of the ligature, the rats in the EP-FUCO group were treated with a single dose of fucoxanthin (200 mg/kg bw) per day for 28 consecutive days. At the end of the study, all of the rats were euthanized and intracardiac blood and mandible tissue samples were obtained for biochemical, immunohistochemical, and histometric analyses. Fucoxanthin treatment resulted in a slight decrease in tumor necrosis factor-α, interleukin-1β, and interleukin-6 levels and a significant decrease in oxidative stress index. It was observed that fucoxanthin caused a significant reduction in receptor activator of nuclear factor kappa-β ligand (RANKL) levels and a statistically non-significant elevation in osteoprotegerin and bone-alkaline phosphatase levels. There were no significant differences in alveolar bone loss levels between the EP and EP-FUCO groups. This experimental study revealed that fucoxanthin provides a limited reduction in alveolar bone resorption in rats with periodontitis. One of the mechanisms underlying the mentioned limited effect might be related to the ability of fucoxanthin to inhibit oxidative stress-related RANKL-mediated osteoclastogenesis.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize 53100, Turkey. dtoguzkose61@hotmail.com.
authors.forename: Oguz
authors.initials: O
authors.lastname: Kose
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25000, Turkey. t-arabaci@hotmail.com.
authors.forename: Taner
authors.initials: T
authors.lastname: Arabaci
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize 53100, Turkey. htcymnglu@hotmail.com.
authors.forename: Hatice
authors.initials: H
authors.lastname: Yemenoglu
authors.affiliation: Department of Histology and Embryology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25000, Turkey. ademkara_36@hotmail.com.
authors.forename: Adem
authors.initials: A
authors.lastname: Kara
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25000, Turkey. seckin.ozkanlar@atauni.edu.tr.
authors.forename: Seckin
authors.initials: S
authors.lastname: Ozkanlar
authors.affiliation: Department of Aquaculture, Faculty of Fisheries Sciences, Recep Tayyip Erdogan University, Rize 53100, Turkey. aquasevki@msn.com.
authors.forename: Sevki
authors.initials: S
authors.lastname: Kayis
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize 53100, Turkey. zeynep.yesilduymus@erdogan.edu.tr.
authors.forename: Zeynep Yesil
authors.initials: ZY
authors.lastname: Duymus
mesh_terms: D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008963:Molar / Q000187:drug effects* / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D053244:Osteoprotegerin / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010518:Periodontitis / Q000188:drug therapy* / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D024341:Xanthophylls / Q000494:pharmacology*
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D053244:Osteoprotegerin; D053245:RANK Ligand; D014409:Tumor Necrosis Factor-alpha; D024341:Xanthophylls; C025164:fucoxanthin; D010744:Phosphoric Monoester Hydrolases
keywords: animal model; antioxidant; experimental periodontitis; fucoxanthin; oxidative stress