title: Efficacy and Toxicity Assessment of Different Antibody Based Antiangiogenic Drugs by Computational Docking Method.
abstract: Bevacizumab and trastuzumab are two antibody based antiangiogenic drugs that are in clinical practice for the treatment of different cancers. Presently applications of these drugs are based on the empirical choice of clinical experts that follow towards population based clinical trials and, hence, their molecular efficacies in terms of quantitative estimates are not being explored. Moreover, different clinical trials with these drugs showed different toxicity symptoms in patients. Here, using molecular docking study, we made an attempt to reveal the molecular rationale regarding their efficacy and off-target toxicity. Though our study reinforces their antiangiogenic potentiality and, among the two, trastuzumab has much higher efficacy; however, this study also reveals that compared to bevacizumab, trastuzumab has higher toxicity effect, specially on the cardiovascular system. This study also reveals the molecular rationale of ocular dysfunction by antiangiogenic drugs. The molecular rationale of toxicity as revealed in this study may help in the judicious choice as well as therapeutic scheduling of these drugs in different cancers.
authors.affiliation: Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, Kolkata 700 126, India.
authors.forename: Sayan
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, Kolkata 700 126, India; Society for Systems Biology & Translational Research, No. 103, Block C, Bangur Avenue, Kolkata 700 055, India.
authors.forename: Gopa
authors.initials: G
authors.lastname: Chatterjee
authors.affiliation: Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, Kolkata 700 126, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Ghosh
authors.affiliation: Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, Kolkata 700 126, India; Society for Systems Biology & Translational Research, No. 103, Block C, Bangur Avenue, Kolkata 700 055, India.
authors.forename: Bishwajit
authors.initials: B
authors.lastname: Das
authors.affiliation: Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, Kolkata 700 126, India; Society for Systems Biology & Translational Research, No. 103, Block C, Bangur Avenue, Kolkata 700 055, India.
authors.forename: Durjoy
authors.identifier: 0000-0002-8121-9228
authors.initials: D
authors.lastname: Majumder