title: Preliminary study on the pathological model of Piyinxu in rats.
abstract: OBJECTIVE
  To study the method of constructing a pathological model of Piyinxu (spleen-yin deficiency) using Sprague-Dawley rats and to make preliminary observations.
  
  
  METHODS
  Folium sennae (0.8 g) and tabellae thyroidei (80 mg) were given daily by stomach feeding to each rat for 12 d to establish the pathological model of Piyinxu. The activity of the rats and the characteristics of their stool were observed.
  
  
  RESULTS
  We observed not only the symptoms of Pixu, such as diarrhea, poor appetite, abdominal distention, weight loss, but also Yinxuneire (endogenous heat), such as increase in water drinking, nervousness, and restlessness. These symptoms were all different from that of the control group of Piyangxu (spleen-yang deficiency).
  
  
  CONCLUSIONS
  Combining folium sennae and tabellae thyroidei is an effective method for establishing a pathological model of Piyinxu.
authors.affiliation: De-Zhen Chen, Mu-Xin Wei, Department of Traditional Chinese Medicine, The First College of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Chen
authors.affiliation: De-Zhen Chen, Mu-Xin Wei, Department of Traditional Chinese Medicine, The First College of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: M X
authors.initials: MX
authors.lastname: Wei
keywords: Disease models, animal; Spleen asthenia/pathology; Spleen-yin