title: Clinical Outcomes and Imaging Findings in Women Undergoing TAVR.
abstract: Transcatheter aortic valve replacement (TAVR) has become the standard of care for patients with hemodynamically severe aortic stenosis who are symptomatic but deemed too high risk for surgery. Recent reports suggest that sex differences exist in outcomes following TAVR and in the diagnostic imaging evaluation of patients being considered for TAVR. In this review, the authors explore the differences between men and women in baseline characteristics and outcomes following TAVR, as well as sex differences in the imaging findings of severe aortic stenosis (AS) including the diagnostic challenges in the hemodynamic assessment of severe AS in elderly women, differences in aortic valvular calcification and in the associated myocardial response to severe AS. Additionally, sex differences in imaging findings as they relate to post-TAVR complications including coronary obstruction, annular rupture and prosthesis-patient mismatch are also discussed.
authors.affiliation: Division of Radiology, St Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Christopher
authors.initials: C
authors.lastname: Naoum
authors.affiliation: Division of Radiology, St Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Philipp
authors.initials: P
authors.lastname: Blanke
authors.affiliation: Division of Cardiology, St Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Danny
authors.initials: D
authors.lastname: Dvir
authors.affiliation: Quebec Heart and Lung Institute/Institut de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec City, Quebec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
authors.affiliation: Division of Cardiology, St Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Karin
authors.initials: K
authors.lastname: Humphries
authors.affiliation: Division of Cardiology, St Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Webb
authors.affiliation: Division of Radiology, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Division of Cardiology, St Paul's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: jleipsic@providencehealth.bc.ca.
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
mesh_terms: D001021:Aortic Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation / Q000401:mortality; D005260:Female; D054624:Health Status Disparities; D054625:Healthcare Disparities; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods* / Q000401:mortality; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D016896:Treatment Outcome
keywords: TAVR; aortic stenosis; aortic valve calcium; sex differences