title: Antibacterial Activity of Cold Atmospheric Pressure Argon Plasma against 78 Genetically Different (mecA, luk-P, agr or Capsular Polysaccharide Type) Staphylococcus aureus Strains.
abstract: Previous studies on the antimicrobial activity of cold atmospheric pressure argon plasma showed varying effects against mecA+ or mecA-Staphylococcus aureus strains. This observation may have important clinical and epidemiological implications. Here, the antibacterial activity of argon plasma was investigated against 78 genetically different S. aureus strains, stratified by mecA, luk-P, agr1-4, or the cell wall capsule polysaccharide types 5 and 8. kINPen09® served as the plasma source for all experiments. On agar plates, mecA+luk-P-S. aureus strains showed a decreased susceptibility against plasma compared to other S. aureus strains. This study underlines the high complexity of microbial defence against antimicrobial treatment and confirms a previously reported strain-dependent susceptibility of S. aureus to plasma treatment.
authors.affiliation: Institute for Hygiene and Environmental Medicine, Universitx00E4;tsmedizin Greifswald, Greifswald, Germany.
authors.forename: Rutger
authors.initials: R
authors.lastname: Matthes
authors.forename: Anne
authors.initials: A
authors.lastname: Lührman
authors.forename: Silva
authors.initials: S
authors.lastname: Holtfreter
authors.forename: Julia
authors.initials: J
authors.lastname: Kolata
authors.forename: Dörte
authors.initials: D
authors.lastname: Radke
authors.forename: Nils-Olaf
authors.initials: NO
authors.lastname: Hübner
authors.forename: Ojan
authors.initials: O
authors.lastname: Assadian
authors.forename: Axel
authors.initials: A
authors.lastname: Kramer
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001128:Argon / Q000008:administration & dosage*; D001274:Atmospheric Pressure; D001426:Bacterial Proteins; D003080:Cold Temperature / Q000009:adverse effects*; D006801:Humans; D010544:Peroxidases; D011135:Polysaccharides, Bacterial / Q000037:antagonists & inhibitors / Q000235:genetics*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D011135:Polysaccharides, Bacterial; D001128:Argon; D010544:Peroxidases; C081610:catalase-peroxidase, bacteria