title: The Quest toward limb regeneration: a regenerative engineering approach.
abstract: The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated limb. The remarkable advances in the scientific understanding of regeneration, stem cell science, material science and engineering, physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound healing. Here we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration.
authors.affiliation: Department of Orthopaedic Surgery, Institute for Regenerative Engineering, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT 06030, USA,; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA.
authors.forename: Cato T
authors.initials: CT
authors.lastname: Laurencin
authors.affiliation: Department of Orthopaedic Surgery, Institute for Regenerative Engineering, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT 06030, USA,; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA.
authors.forename: Lakshmi S
authors.initials: LS
authors.lastname: Nair
keywords: advanced biomaterial science; clinical translation; limb regeneration; regenerative engineering; stem cells