title: Chemical composition and antimicrobial activity of the essential oils of Onychopetalum amazonicum R.E.Fr.
abstract: The essential oils from leaves, twigs and trunk bark of Onychopetalum amazonicum R.E. Fr. (Annonaceae), obtained by hydrodistillation, were analysed by GC and GC-MS, and also were evaluated for in vitro antimicrobial activity. Forty-one compounds, which correspond to 75.0-92.2% of the oil components, were identified. Major compounds were sesquiterpenes, including (E)-caryophyllene, caryophyllene oxide, spathulenol, α-gurjunene, allo-aromadendrene and α-epi-cadinol. The oils were evaluated for antimicrobial activities against four bacteria strains and five pathogenic fungi. The oil of the trunk bark exhibited good activity against Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 10538 and Kocuria rhizophila ATCC 9341, with a minimal inhibitory concentration of 62.5 μg/mL. The essential oil composition and the antimicrobial evaluation are reported for the first time for the genus Onychopetalum.
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Bruna R
authors.initials: BR
authors.lastname: de Lima
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Felipe M A
authors.initials: FM
authors.lastname: da Silva
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Elzalina R
authors.initials: ER
authors.lastname: Soares
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Richardson A
authors.initials: RA
authors.lastname: de Almeida
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Francinaldo A
authors.initials: FA
authors.lastname: da Silva Filho
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Raimundo C
authors.initials: RC
authors.lastname: Pereira Junior
authors.affiliation: b Instituto de Biologia , Universidade Estadual de Campinas , Campinas , Brazil.
authors.forename: Álvaro J
authors.initials: ÁJ
authors.lastname: Hernandez Tasco
authors.affiliation: b Instituto de Biologia , Universidade Estadual de Campinas , Campinas , Brazil.
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Salvador
authors.affiliation: c Grupo DeMpSter de Espectrometria de Massas , Universidade do Estado do Amazonas , Manaus , Brazil.
authors.forename: Hector H F
authors.initials: HH
authors.lastname: Koolen
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Afonso D L
authors.initials: AD
authors.lastname: de Souza
authors.affiliation: a Departamento de Química , Universidade Federal do Amazonas , Manaus , Brazil.
authors.forename: Maria L B
authors.initials: ML
authors.lastname: Pinheiro
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D052176:Azulenes / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000032:analysis / Q000302:isolation & purification; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D052176:Azulenes; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; C510134:aromadendrene; C445364:cadinol; C013258:spathulenol; C024714:caryophyllene; C515179:caryophyllene oxide
keywords: Annonaceae; Onychopetalum amazonicum; antimicrobial evaluation; essential oil