title: Efficacy and Safety of Minoxidil 2% Solution in Combination With a Botanical Hair Solution in Women With Female Pattern Hair Loss/Androgenic Alopecia.
abstract: Female pattern hair loss (FPHL), also known as female androgenic alopecia, affects over 21 million women in the United States with devastating effects on self-esteem and psychosocial functioning. Topical minoxidil 2% and 5% formulations are the only US Food and Drug Administration-approved treatments for FPHL. The length of time it typically takes to observe the benefits is a challenge for many patients, and may affect adherence to treatment. Herbal extracts, which are also believed to promote healthier-looking hair, have a long history of use in hair care formulations. The safety and efficacy of a twice-daily regimen of 2% minoxidil solution used in combination with the botanical hair solution for 12 weeks in 54 subjects was evaluated in a multicenter, single-arm, open-label study. Assessments included investigator and subject ratings of improvement and subject satisfaction. Investigator ratings indicated significant improvement in hair growth and overall treatment benefits in as early as 6 weeks (P<.001). Subject self-ratings indicated significant satisfaction with hair volume and quality improvement at week 6 (P<.001). Subjects also indicated an increase in self-confidence and attractiveness at week 12 (P<.001). The investigator and subject-assessed efficacy and subject satisfaction with this regimen provides clinicians with an effective treatment option for FPHL that also provides a high level of patient acceptance, which ultimately may help promote minoxidil treatment adherence.
authors.forename: Amy
authors.initials: A
authors.lastname: McMichael
authors.forename: Hanh
authors.initials: H
authors.lastname: Pham
authors.forename: Erika
authors.initials: E
authors.lastname: von Grote
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Meckfessel
mesh_terms: D000328:Adult; D000505:Alopecia / Q000175:diagnosis* / Q000188:drug therapy*; D004339:Drug Compounding; D004359:Drug Therapy, Combination; D005260:Female; D006203:Hair Preparations / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008875:Middle Aged; D008914:Minoxidil / Q000008:administration & dosage* / Q000737:chemistry; D017060:Patient Satisfaction; D019999:Pharmaceutical Solutions / Q000008:administration & dosage / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D006203:Hair Preparations; D019999:Pharmaceutical Solutions; D010936:Plant Extracts; D008914:Minoxidil