title: The cytokine interleukin-26 as a biomarker in pediatric asthma.
abstract: In this pilot study, we examined associations between local interleukin (IL)-26, disease severity and biomarkers of Th2-mediated inflammation in a well-defined cohort of pediatric patients (14 years median age, 41 % females) with controlled (n = 28) or uncontrolled (n = 48) asthma. Sputum IL-26 protein concentrations (ELISA) reflected disease control in patients without local (low exhaled nitric oxide) or systemic (low blood eosinophils) signs of eosinophilic inflammation. Moreover, sputum-IL-26 concentrations correlated with those of blood neutrophils. Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation.
authors.affiliation: Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, SE-171 76, Stockholm, Sweden.|Centre for Allergy Research, Karolinska Institutet, SE-171 77, Stockholm, Sweden.|Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.
authors.forename: Jon R
authors.initials: JR
authors.lastname: Konradsen
authors.affiliation: Centre for Allergy Research, Karolinska Institutet, SE-171 77, Stockholm, Sweden.|Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.|Department of Women's and Children's Health, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Nordlund
authors.affiliation: Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, SE-17177, Stockholm, Sweden.
authors.forename: Bettina
authors.initials: B
authors.lastname: Levänen
authors.affiliation: Centre for Allergy Research, Karolinska Institutet, SE-171 77, Stockholm, Sweden.|Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.|Department of Women's and Children's Health, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
authors.forename: Gunilla
authors.initials: G
authors.lastname: Hedlin
authors.affiliation: Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, SE-17177, Stockholm, Sweden. anders.linden@ki.se.|Lung Allergy Clinic, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden. anders.linden@ki.se.
authors.forename: Anders
authors.initials: A
authors.lastname: Linden
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D015415:Biomarkers; D002648:Child; D016207:Cytokines / Q000032:analysis; D005260:Female; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013183:Sputum / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; C406767:IL26 protein, human; D007378:Interleukins
keywords: Asthma; Children; Eosinophil; FENO; IL-26; Neutrophil; Sputum