title: Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness.
abstract: Obstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88± 0.26 mm vs 0.75±0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA.
authors.affiliation: Department of Pulmonology, Ataturk Chest and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Karamanli
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Mevlana University, Konya, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Kiyici
authors.affiliation: Department of Radiology, Faculty of Medicine, Mevlana University, Konya, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Arik
authors.affiliation: Department of Radiology, Faculty of Medicine, Mevlana University, Konya, Turkey.
authors.forename: Duran
authors.initials: D
authors.lastname: Efe
authors.affiliation: Department of Pulmonology, Faculty of Medicine, Ordu University, Ordu, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Akgedik
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D000075462:Serum Albumin, Human; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015415:Biomarkers; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Atherosclerosis; Hypoxia; Oxidants; Sleep Apnea, Obstructive