title: Recurrent optic neuritis and neuromyelitis optica-IgG following first and second human papillomavirus vaccinations.
abstract: Human papillomavirus (HPV) vaccine is widely used to prevent cervical cancer caused by certain types of HPV in girls and young women. Demyelinating disorders within months following HPV innoculation have been reported, but the causal link between HPV vaccination and the onset of demyelinating disorders have not been certain. We report a case of neuromyelitis optica spectrum disorder (NMOSD) that was noteworthy because optic neuritis (ON) occurred in a very close temporal association with both the first and second HPV vaccinations, which might suggest an association between HPV vaccination and the development of NMO-IgG and recurrent ON. This emphasizes the necessity for continuing surveillance for adverse events after HPV vaccination.
authors.affiliation: Department of Neurology, College of Medicine, Chungbuk National University, South Korea.
authors.forename: Hyeyeon
authors.initials: H
authors.lastname: Chang
authors.affiliation: Department of Neurology, College of Medicine, Chungbuk National University, South Korea.
authors.forename: Hye Lim
authors.initials: HL
authors.lastname: Lee
authors.affiliation: Department of Neurology, College of Medicine, Chungbuk National University, South Korea.
authors.forename: Minju
authors.initials: M
authors.lastname: Yeo
authors.affiliation: Department of Neurology, College of Medicine, Chungbuk National University, South Korea.
authors.forename: Ji Seon
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, College of Medicine, Chungbuk National University, South Korea.
authors.forename: Dong-Ick
authors.initials: DI
authors.lastname: Shin
authors.affiliation: Department of Neurology, College of Medicine, Chungbuk National University, South Korea.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Department of Neurology, College of Medicine, Chungbuk National University, South Korea. Electronic address: sunghlee@chungbuk.ac.kr.
authors.forename: Sung-Hyun
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009471:Neuromyelitis Optica / Q000000981:diagnostic imaging* / Q000209:etiology; D009902:Optic Neuritis / Q000000981:diagnostic imaging* / Q000209:etiology; D053918:Papillomavirus Vaccines / Q000009:adverse effects*; D012008:Recurrence; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D053918:Papillomavirus Vaccines
keywords: Autoimmune demyelinating disease; Human papillomavirus vaccine; Neuromyelitis optica; Optic neuritis