title: Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up.
abstract: The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
authors.affiliation: Department of Science and Technologic Innovation, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121, Alessandria, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Muñoz Úbeda
authors.affiliation: Department of Science and Technologic Innovation, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121, Alessandria, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Carniato
authors.affiliation: Department of Science and Technologic Innovation, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121, Alessandria, Italy.|Department of Molecular Biotechnology and Health Science & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10126, Torino, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Catanzaro
authors.affiliation: Institute for Biostructures and Bioimages (CNR) c/o, Molecular Biotechnology Center, Via Nizza 52, 10126, Torino, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Padovan
authors.affiliation: Department of Medical Sciences, University of Turin, Via Nizza 52, 10126, Torino, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Grange
authors.affiliation: Department of Molecular Biotechnology and Health Science & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10126, Torino, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Porta
authors.affiliation: Department of Molecular Biotechnology and Health Science & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10126, Torino, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Carrera
authors.affiliation: Department of Science and Technologic Innovation, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121, Alessandria, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tei
authors.affiliation: Department of Science and Technologic Innovation, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121, Alessandria, Italy. giuseppe.digilio@uniupo.it.
authors.forename: Giuseppe
authors.identifier: 0000-0003-2397-2913
authors.initials: G
authors.lastname: Digilio
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D064987:Cell- and Tissue-Based Therapy; D003094:Collagen / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008863:Microspheres; D010084:Oxidation-Reduction; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D004220:Disulfides; D020100:Hydrogels; D012822:Silicon Dioxide; D006820:Hyaluronic Acid; D003094:Collagen; D005682:Gadolinium
keywords: cellular imaging; gadolinium; magnetic resonance imaging; redox-responsive; silica microspheres