title: Primary trabeculotomy compared to combined trabeculectomy-trabeculotomy in congenital glaucoma: 3-year study.
abstract: OBJECTIVE
  To compare the outcome of primary trabeculotomy with that of combined trabeculectomy-trabeculotomy (CTT) with mitomycin C (MMC) in children with congenital glaucoma.
  
  
  METHODS
  This is a prospective comparative study, carried out on a cohort of 28 eyes (28 infants) with congenital glaucoma. Infants with proved congenital glaucoma [based on intra-ocular pressure (IOP), cup/disc (C/D ratio), corneal diameter and axial length measurements] were randomly allocated to either group A (trabeculotomy) or group B (CTT with MMC). Postoperatively, all patients were followed regularly for 3 years; for IOP and C/D evaluation. Criteria for successful outcome included resolution of corneal oedema, reversal of disc cupping, and IOP 18 mmHg or less.
  
  
  RESULTS
  Success rate in each group was 85.7% (p = 1.00). All preoperative parameters, including horizontal corneal diameter, axial length, IOP and C/D ratio, were not statistically significantly different between the two groups. Also, postoperative C/D ratio, IOP, IOP difference and percentage difference (compared to preoperative values), at different follow-up visits, were not statistically significantly different between both surgical techniques. Comparing preoperative to postoperative IOP and C/D ratio in each group was statistically significant.
  
  
  CONCLUSIONS
  Both primary trabeculotomy and CTT with MMC had similar outcomes, which could mean that trabeculotomy could be resorted to first.
authors.affiliation: Department of Ophthalmology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Dalia H
authors.initials: DH
authors.lastname: Khalil
authors.affiliation: Department of Ophthalmology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt. m.amr.salah@kasalainy.edu.reg.
authors.forename: Mohamad A S E
authors.initials: MA
authors.lastname: Abdelhakim
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006871:Hydrophthalmos / Q000503:physiopathology / Q000601:surgery*; D007223:Infant; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000601:surgery*; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin
keywords: combined trabeculotomy-trabeculectomy; congenital glaucoma; success rate; trabeculotomy