title: Assessment of Small Intestinal Transit Times in Ulcerative Colitis and Crohn's Disease Patients with Different Disease Activity Using Video Capsule Endoscopy.
abstract: Small intestinal transit times (SITT) influence drug bioavailability. This study aimed to compare SITT in Crohn's disease and ulcerative colitis patients with non-inflammatory bowel disease (IBD) and to determine influence of disease activity on transit times, and in addition, to establish the utility of small bowel video capsule endoscopy (SB-VCE) in investigation of SITT in IBD patients. A retrospective review was performed on consecutive patients who had undergone SB-VCE at a university hospital out-patient clinic. In total, 125 non-IBD patients, 55 Crohn's disease patients, and 23 ulcerative colitis patients were included. SITT were calculated from the first duodenal image to the first cecal image. Disease activity was assessed based on endoscopy results and inflammatory markers (calprotectin, C-reactive protein, erythrocyte sedimentation rate). SITT were longer in ulcerative colitis patients compared to non-IBD patients (median 264 min vs. 216 min, p = 0.010). Patients with active Crohn's disease (n = 33) also displayed prolonged SITT compared to non-IBD patients (median 253 min vs 216 min, p = 0.017) and patients with quiescent Crohn's disease (n = 22) (p = 0.005). SITT can be prolonged in IBD patients depending on disease activity which may alter the drug release profiles and clinical response to colonic drug delivery systems. SB-VCE is a simple, non-invasive tool that can be utilized in pharmacokinetic studies to understand drug bioavailability in different patient groups. Moreover, this variability in transit times needs to be simulated in dissolution testing for in vitro in vivo correlations.
authors.affiliation: Indiana University Division of Gastroenterology and Hepatology, Indianapolis, Indiana, USA.
authors.forename: Monika
authors.initials: M
authors.lastname: Fischer
authors.affiliation: Indiana University Division of Gastroenterology and Hepatology, Indianapolis, Indiana, USA.
authors.forename: Shivi
authors.initials: S
authors.lastname: Siva
authors.affiliation: Indiana University Division of Gastroenterology and Hepatology, Indianapolis, Indiana, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Wo
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, Indiana, 46208, USA. hfadda@butler.edu.
authors.forename: Hala M
authors.initials: HM
authors.lastname: Fadda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D053704:Capsule Endoscopy / Q000379:methods; D003093:Colitis, Ulcerative / Q000378:metabolism* / Q000503:physiopathology*; D003424:Crohn Disease / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: gastrointestinal transit; in vitro in vivo correlations; modified release; oral drug delivery; small intestine