title: [The shades of anti-Jo1 positive antisynthetase syndrome in a Hungarian cohort].
abstract: BACKGROUND
  In idiopathic inflammatory myopathies, the presence of anti-Jo-1 antibody defines a distinct clinical phenotype (myositis, arthritis, interstitial lung disease, Raynaud's phenomenon fever, mechanic's hands), called antisynthetase syndrome.
  
  
  OBJECTIVE
  To determine the demographic data as well as clinical, laboratory and terapeutical features of anti-Jo1 positive patients, followed by the department of the authors.
  
  
  METHODS
  The medical records of 49 consecutive anti-Jo1 patients were reviewed.
  
  
  RESULTS
  Demographic and clinical results were very similar to those published by other centers. Significant correlation was found between the anti-Jo-1 titer and the creatine kinase and C-reactive protein levels. Distinct laboratory results measured at the time of diagnosis of the disease (C-reactive protein, antigen A associated with Sjogren's syndrome, positive rheumatoid factor), and the presence of certain clinical symptoms (fever, vasculitic skin) may indicate a worse prognosis within the antisyntetase positive patient group.
  
  
  CONCLUSIONS
  In the cases above more agressive immunosuppressive therapy may be required.
authors.affiliation: Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ Debrecen, Móricz Zs. út 22., 4032.
authors.forename: Katalin
authors.initials: K
authors.lastname: Szabó
authors.affiliation: Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ Debrecen, Móricz Zs. út 22., 4032.
authors.forename: Melinda
authors.initials: M
authors.lastname: Nagy-Vincze
authors.affiliation: Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ Debrecen, Móricz Zs. út 22., 4032.
authors.forename: Levente
authors.initials: L
authors.lastname: Bodoki
authors.affiliation: Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ Debrecen, Móricz Zs. út 22., 4032.
authors.forename: Katalin
authors.initials: K
authors.lastname: Hodosi
authors.affiliation: Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ Debrecen, Móricz Zs. út 22., 4032.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dankó
authors.affiliation: Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ Debrecen, Móricz Zs. út 22., 4032.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Griger
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000276:immunology; D005260:Female; D005334:Fever / Q000276:immunology; D006801:Humans; D006814:Hungary; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017563:Lung Diseases, Interstitial / Q000276:immunology; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009220:Myositis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D017285:Polymyositis / Q000276:immunology; D011928:Raynaud Disease / Q000276:immunology; D012189:Retrospective Studies; D000069283:Rituximab / Q000627:therapeutic use; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000276:immunology; D014657:Vasculitis / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear; D018501:Antirheumatic Agents; D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; C046750:Jo-1 antibody; D000069283:Rituximab; D002097:C-Reactive Protein; D003402:Creatine Kinase
keywords: anti-Jo-1; anti-Jo1; antisynthetase syndrome; antiszintetáz-szindróma; dermatomyositis; polymyositis