title: Pin1 is related with clinical stage of papillary thyroid carcinoma.
abstract: BACKGROUND
  The context and aim of this article was to investigate whether the expression level of Pin1 was in association with the clinical stage of papillary thyroid carcinomas.
  
  
  METHODS
  Seventy-two patients who had been treated at the Affiliated Hospital of Qingdao University - Yantai YuHuangDing Hospital during January 2013 to December 2014 were rolled in. The expression levels of Pin1 using immunohistochemistry were tested and were divided into four groups according to the different clinical stages and final scores based on multiplying intensity and percentage value of IHC results. Data was analyzed with SPSS 20.0, and P value <0.05 had been chosen as significant.
  
  
  RESULTS
  Considered from analysis result, the Pin1 expression status statistically significantly correlated with the PTC clinical stages (χ(2) = 8.128, P = 0.043); as the clinical stage proceeded, the intensity of Pin1 in PTC cells had been increased. But we did not find any relationships between immunohistochemical staining results and other clinicopathological characteristics.
  
  
  CONCLUSIONS
  The PTC cells' intensity of Pin1 was in association with the clinical stage. The role played by Pin1 in PTC has been studied, and we need to further investigate the application of Pin1 in the treatment of PTC.
authors.affiliation: Gastrointestinal Surgery Ward I, Thyroid Surgery Ward, Affiliated Hospital of Qingdao University - Yantai YuHuangDing Hospital, Yantai, Shandong, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Gastrointestinal Surgery Ward I, Thyroid Surgery Ward, Affiliated Hospital of Qingdao University - Yantai YuHuangDing Hospital, Yantai, Shandong, China. chuhaidi@hotmail.com.
authors.forename: Haidi
authors.initials: H
authors.lastname: Chu
authors.affiliation: Gastrointestinal Surgery Ward I, Thyroid Surgery Ward, Affiliated Hospital of Qingdao University - Yantai YuHuangDing Hospital, Yantai, Shandong, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Zheng
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000556:secondary*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000378:metabolism / Q000556:secondary*; D000072340:NIMA-Interacting Peptidylprolyl Isomerase / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human
keywords: Immunohistochemistry; Oncogenic signaling pathway; Papillary thyroid carcinoma; Pin1; Treatment