title: Clinical repigmentation patterns in paediatric vitiligo.
abstract: BACKGROUND
  Repigmentation is an essential outcome measure in vitiligo. However, clinical studies describing vitiligo repigmentation patterns are lacking.
  
  
  OBJECTIVE
  To assess and clearly define the repigmentation patterns in a series of patients with vitiligo, correlating these with clinicoepidemiological characteristics.
  
  
  METHODS
  Patients with vitiligo seen at least at twice (initial consultation and follow-up visit) in the Department of Paediatric Dermatology, Hôpital Pellegrin des Enfants, Bordeaux University Hospital from 2006 to 2014 were included. Clinical photographs and case records were reviewed.
  
  
  RESULTS
  There were 109 patients (64 female, 45 male) mostly with Fitzpatrick skin type III (n = 67, 61%). The majority had nonsegmental (n = 71, 65%) or segmental vitiligo (n = 29, 27%). In total 172 representative vitiligo lesions were analysed. Overall, a combined pattern of repigmentation was most commonly seen (n = 106, 62%). The combined pattern occurred more frequently in patients with segmental vs. nonsegmental vitiligo (P = 0·009), whereas the diffuse pattern was more frequent in the latter (P = 0·007). Diffuse repigmentation was the predominant pattern on the eyelids (P < 0·001). We observed a new pattern in sites with few to absent hair follicles, which we propose to call 'medium spotted repigmentation'. This begins as circular macules of repigmentation, wider than 5 mm in diameter, which, from the outset, are larger than the initial macules of perifollicular repigmentation. This study is limited by its retrospective nature and small sample size for subgroup assessment.
  
  
  CONCLUSIONS
  The combined pattern of repigmentation was most frequently observed. Medium spotted repigmentation is a new pattern, which will benefit from larger studies for a better understanding.
authors.affiliation: Department of Paediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France. emily.ganyp@gmail.com.
authors.forename: E Y
authors.initials: EY
authors.lastname: Gan
authors.affiliation: Department of Paediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France.
authors.forename: T
authors.initials: T
authors.lastname: Gahat
authors.affiliation: University of Bordeaux and INSERM U1035, University of Bordeaux, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Cario-André
authors.affiliation: Department of Paediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France.|University of Bordeaux and INSERM U1035, University of Bordeaux, Bordeaux, France.
authors.forename: J
authors.initials: J
authors.lastname: Seneschal
authors.affiliation: Department of Paediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France.|University of Bordeaux and INSERM U1035, University of Bordeaux, Bordeaux, France.
authors.forename: K
authors.initials: K
authors.lastname: Ezzedine
authors.affiliation: Department of Paediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France.|University of Bordeaux and INSERM U1035, University of Bordeaux, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Taïeb
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003879:Dermatologic Agents / Q000627:therapeutic use; D005141:Eyelid Diseases / Q000473:pathology / Q000628:therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012880:Skin Pigmentation; D014467:Ultraviolet Therapy; D014820:Vitiligo / Q000473:pathology* / Q000628:therapy
chemical_list: D003879:Dermatologic Agents; D005938:Glucocorticoids; D011241:Prednisone