title: Zwitterionic polymer functionalization of polysulfone membrane with improved antifouling property and blood compatibility by combination of ATRP and click chemistry.
abstract: The chemical compositions are very important for designing blood-contacting membranes with good antifouling property and blood compatibility. In this study, we propose a method combining ATRP and click chemistry to introduce zwitterionic polymer of poly(sulfobetaine methacrylate) (PSBMA), negatively charged polymers of poly(sodium methacrylate) (PNaMAA) and/or poly(sodium p-styrene sulfonate) (PNaSS), to improve the antifouling property and blood compatibility of polysulfone (PSf) membranes. Attenuated total reflectance-Fourier transform infrared spectra, X-ray photoelectron spectroscopy and water contact angle results confirmed the successful grafting of the functional polymers. The antifouling property and blood compatibility of the modified membranes were systematically investigated. The zwitterionic polymer (PSBMA) grafted membranes showed good resistance to protein adsorption and bacterial adhesion; the negatively charged polymer (PNaSS or PNaMAA) grafted membranes showed improved blood compatibility, especially the anticoagulant property. Moreover, the PSBMA/PNaMAA modified membrane showed both antifouling property and anticoagulant property, and exhibited a synergistic effect in inhibiting blood coagulation. The functionalization of membrane surfaces by a combination of ATRP and click chemistry is demonstrated as an effective route to improve the antifouling property and blood compatibility of membranes in blood-contact.
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiang
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lu
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China; Fiber and Polymer Technology, School of Chemical Science and Engineering, KTH Royal Institute of Technology, Teknikringen 56-58, SE-100 44 Stockholm, Sweden. Electronic address: zhaoscukth@163.com.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Zhao
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Shu-Dong
authors.initials: SD
authors.lastname: Sun
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China. Electronic address: zhaochsh70@163.com.
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives / Q000737:chemistry; D002417:Cattle; D057930:Click Chemistry; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D011137:Polystyrenes / Q000138:chemical synthesis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013211:Staphylococcus aureus / Q000378:metabolism; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D008567:Membranes, Artificial; D011108:Polymers; D011109:Polymethacrylic Acids; D011137:Polystyrenes; D013450:Sulfones; C017662:polysulfone P 1700; D012710:Serum Albumin, Bovine; D001622:Betaine; C003321:polystyrene sulfonic acid; C483727:sulfobetaine
keywords: ATRP; Antifouling; Blood compatibility; Click chemistry; Zwitterionic polymer