title: Caprine leptospirosis: Hematobiochemical and urinalyses studies.
abstract: OBJECTIVE
  The present study was designed to evaluate clinicopathological alterations in naturally occurring leptospirosis in goats of South Gujarat region, Gujarat.
  
  
  METHODS
  A total 459 blood/serum and 292 urine samples were collected from different districts of South Gujarat region, India. Blood/serum and urine samples were subjected to hematobiochemical analyses and urinalyses. The serum samples were screened for anti-leptospiral antibodies using the microscopic agglutination test (MAT). On the bases of presence or absence of anti-leptospiral antibodies in serum, seropositive and seronegative groups were made. The results were analyzed using standard statistical methods to know pathological changes in the disease.
  
  
  RESULTS
  In MAT, out of 459, 116 goats were seropositive, and 343 were seronegative. In hematobiochemical analyses, statistically significant (p<0.01) decrease in values of packed cell volume, hemoglobin (Hb) concentration, mean corpuscular Hb concentration and total protein and increased activity/level of alanine aminotransferase, aspartate aminotransferase and total bilirubin between seropositive and seronegative goats were noted. Urinalyses did not reveal any specific changes. In the dark field microscopy, urine samples were found to be negative for leptospires.
  
  
  CONCLUSIONS
  Hematobiochemical changes noted in seropositive goats were indicative of hepatic damage, and this knowledge would aid in the therapeutic management of the disease.
authors.affiliation: Department of Veterinary Pathology, Vanbandhu College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari - 396 450, Gujarat, India.
authors.forename: Priti Dilipsinh
authors.initials: PD
authors.lastname: Vihol
authors.affiliation: Department of Veterinary Pathology, Vanbandhu College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari - 396 450, Gujarat, India.
authors.forename: Jignesh M
authors.initials: JM
authors.lastname: Patel
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Vanbandhu College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari - 396 450, Gujarat, India.
authors.forename: Jatin H
authors.initials: JH
authors.lastname: Patel
authors.affiliation: Department of Veterinary Pathology, Vanbandhu College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari - 396 450, Gujarat, India.
authors.forename: Mahesh C
authors.initials: MC
authors.lastname: Prasad
authors.affiliation: Department of Veterinary Microbiology, Vanbandhu College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari - 396 450, Gujarat, India.
authors.forename: Irsadullakhan H
authors.initials: IH
authors.lastname: Kalyani
authors.affiliation: Department of Animal Genetics and Breeding, Vanbandhu College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari - 396 450, Gujarat, India.
authors.forename: Balkrushna P
authors.initials: BP
authors.lastname: Brahmkshtri
keywords: goats; hematobiochemical; leptospirosis; urinalysis