title: A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain.
abstract: BACKGROUND
  To study the effect of Lanconone® (1000 mg) on acute pain on exertion as compared to the standard of care, Ibuprofen (400 mg).
  
  
  METHODS
  The study recruited 72 subjects diagnosed with mild to moderate knee joint pain on exertion. Subjects with Pain Visual Analogue Scale of more than 40 mm were included. Uphill walking was provided as the stressor using Naughton's protocol on a treadmill. The subjects walked for 10 minutes continuously followed by a rest period and baseline pain score for index knee joint was recorded. Subjects were administered a single dose of Lanconone® (1000 mg)/Ibuprofen (400 mg). Thereafter the same stressor was provided at 0.5, 1, 2, 3, 4, and 6 hours, subsequently, pain scores were recorded on a visual analogue scale. Double stopwatch method was used to evaluate the onset of pain relief and time taken to meaningful pain relief.
  
  
  RESULTS
  Both Lanconone® and Ibuprofen showed the first perceived pain relief at 65.31 ± 35.57 mins as compared to 60.82 ± 32.56 mins respectively. The mean time taken to experience meaningful pain relief in Lanconone® group was 196.59 ± 70.85 mins compared to 167.13 ± 71.41 mins amongst Ibuprofen group. The meaningful pain relief continued for 6 hours.
  
  
  CONCLUSIONS
  The current study successfully demonstrated rapid pain-relieving potential of Lanconone® which was comparable to Ibuprofen. No adverse event related to the interventions was reported in the study.
  
  
  BACKGROUND
  Clinical trials.gov NCT02417506 . 21 January 2015.
authors.affiliation: Department of Biological Sciences, University of Southern California, Greater Los Angeles, CA, USA.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Girandola
authors.affiliation: Research & Development, Enovate Biolife, Wilmington, DE, USA. shalini@enovatebiolife.com.
authors.forename: Shalini
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: ANIXIS Biomedical Consulting, Chapel Hill, NC, USA.
authors.forename: Costas C
authors.initials: CC
authors.lastname: Loullis
mesh_terms: D059787:Acute Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D000328:Adult; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D018771:Arthralgia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D007719:Knee Joint / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D058748:Pain Perception / Q000187:drug effects*; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D011930:Reaction Time; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D016138:Walking
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D007052:Ibuprofen
keywords: Analgesic; Arthritis; Glucosamine; Health supplement; Ibuprofen; Joint pain; Nonsteroidal anti-inflammatory drug; Rapid pain relief; Trauma; Visual analogue scale