title: The Effect of Topical Diquafosol Tetrasodium 3% on Dry Eye After Cataract Surgery.
abstract: To evaluate the effectiveness of 3% diquafosol tetrasodium for treating dry eye after cataract surgery.
  
  
  
  Among patients who underwent bilateral cataract surgery, 34, who met the diagnostic criteria for dry eye syndrome 1 week postoperatively, were enrolled. Patients were randomly assigned to receive 3.0% diquafosol tetrasodium ophthalmic solution in one eye and 0.9% saline in the other eye four times daily for 8 weeks. Dry eye severity was measured at 1, 5, and 9 postoperative weeks using the Schirmer 1 test (SIT), tear film breakup time (TBUT), and fluorescein corneal staining. tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) measured using Fourier-domain optical coherence tomography and symptom questionnaire scores.
  
  
  
  TBUT and corneal staining significantly improved 8 weeks postoperatively in eyes treated with 3.0% diquafosol tetrasodium (p < 0.01, p < 0.01) and were better than normal saline-treated eyes (p < 0.01, p < 0.01). SIT did not improve (p = 0.26). TMH, TMD, and TMA did not improve at 4 and 8 weeks. All symptom questionnaire scores improved in eyes treated with 3.0% diquafosol tetrasodium (all p < 0.01).
  
  
  
  The 3.0% diquafosol tetrasodium treatment improved tear film stability and subjective symptoms of dry eye after cataract surgery. Increased mucin production as a result of diquafosol treatment may have caused these results.
authors.affiliation: a Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Korea.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Baek
authors.affiliation: b Department of Ophthalmology and Visual Science, St. Paul's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Korea.
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Doh
authors.affiliation: b Department of Ophthalmology and Visual Science, St. Paul's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Korea.
authors.forename: Sung Kun
authors.initials: SK
authors.lastname: Chung
mesh_terms: D000287:Administration, Topical; D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011122:Polyphosphates / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013666:Tears / Q000378:metabolism*; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014500:Uracil Nucleotides / Q000008:administration & dosage*
chemical_list: D009883:Ophthalmic Solutions; D011122:Polyphosphates; D014500:Uracil Nucleotides; C403315:diquafosol
keywords: Cataract surgery; diquafosol tetrasodium 3%; dry eye syndrome; tear film breakup time; tear meniscus