title: Effects of concurrent perioperative use of marbofloxacin and cimicoxib or carprofen in dogs.
abstract: OBJECTIVE
  To investigate possible interactions visible on electroencephalogram recordings caused by concomitant administration of marbofloxacin and carprofen or cimicoxib in dogs without central nervous system disease.
  
  
  METHODS
  Totally 21 client-owned dogs undergoing different surgeries were included in a randomised, blinded, clinical study. Each dog was assigned to one of two groups treated with either carprofen or cimicoxib pre- and postoperatively. After anaesthetic induction both groups received marbofloxacin intravenously while recording an electroencephalogram. Offline electroencephalogram analysis included qualitative evaluation and Fast Fourier Transformation. Postoperative analgesia was evaluated for 24 hours and after 10 days with the short-form Glasgow Composite Measure Pain Scale. Statistical analysis included Wilcoxon signed rank test, Mann-Whitney U test and Student's t-test with α set at 5%.
  
  
  RESULTS
  Marbofloxacin injection caused no effects on quantitative and qualitative electroencephalogram parameters in both groups. No differences in postoperative pain scoring were found between treatment groups.
  
  
  CONCLUSIONS
  Concurrent use of marbofloxacin with either cimicoxib or carprofen did not induce neuroexcitatory activities in dogs without CNS disease directly after administration.
authors.affiliation: Department of Anaesthesia, Small Animal Clinic, University of Veterinary Medicine Hannover Foundation, Hannover 30159, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Weil
authors.affiliation: Department of Anaesthesia, Small Animal Clinic, University of Veterinary Medicine Hannover Foundation, Hannover 30159, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Tünsmeyer
authors.affiliation: Department of Neurology, Small Animal Clinic, University of Veterinary Medicine Hannover Foundation, Hannover 30159, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Tipold
authors.affiliation: Department of Internal Medicine, Small Animal Clinic, University of Veterinary Medicine Hannover Foundation, Hannover 30159, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Hoppe
authors.affiliation: Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover Foundation, Hannover 30159, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Beyerbach
authors.affiliation: Vétoquinol GmbH, Ravensburg 88212, Germany.
authors.forename: W-R
authors.initials: WR
authors.lastname: Pankow
authors.affiliation: Department of Anaesthesia, Small Animal Clinic, University of Veterinary Medicine Hannover Foundation, Hannover 30159, Germany.
authors.forename: S B
authors.initials: SB
authors.lastname: Kästner
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002227:Carbazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects / Q000662:veterinary; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007430:Intraoperative Care; D008297:Male; D009422:Nervous System Diseases / Q000662:veterinary; D059035:Perioperative Period; D011446:Prospective Studies; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D024841:Fluoroquinolones; D007093:Imidazoles; D013449:Sulfonamides; C080260:marbofloxacin; C007005:carprofen; C493522:cimicoxib