title: [Cyanocobalamin-containing lubricant for topical therapy of LASIK-associated dry eye].
abstract: OBJECTIVE
  to study the effect of topical treatment with Artelac Balance, a cyanocobalamin-containing lubricant, in patients with post-LASIK corneal neuropathy and LASIK-associated dry eye.
  
  
  METHODS
  Patients scheduled for LASIK were enrolled. Inclusion criteria were contact lens wear for 5 years or longer and more than 6 diopters of myopia. The patients were divided into 3 groups. Group 1 was prescribed the cyanocobalamin-containing topical lubricant for 3 months before and 1 month after surgery, group 2 - the same cyanocobalamin-containing lubricant, but only for the first month after surgery, and group 3 received a standard preservative-free lubricant for the first month after surgery. Tear osmolarity and production as well as corneal sensitivity were assessed 90±10 days before and 30±3 days after surgery. The percentage of patients with dry eye symptoms and those who required prolonged use of lubricants were also estimated at day 30±3.
  
  
  RESULTS
  Preoperatively, there were no statistically significant differences in demographic characteristics, tear osmolarity, tear production, or corneal sensitivity between the three study groups. At day 30±3 after surgery, tear production and corneal sensitivity were both significantly higher in group 1 than in group 3 (16.8 mm vs. 13.2 mm, p=0.003 and 37.7±3.1 mm vs. 32.4±2.2 mm, p=0.023, respectively). As to the percentage of patients with dry eye symptoms and those who required prolonged use of lubricants, it was lower in group 1 than in group 3 (51.3% vs. 76.3%, p=0.03 and 38.5% vs. 63.2%, p=0.03, respectively). Between the groups 2 and 3, none of the studied parameters differed significantly.
  
  
  CONCLUSIONS
  Combined pre- and postoperative use of Artelac Balance, a cyanocobalamin-containing lubricant, has been proved effective in restoring corneal sensitivity and reducing dry eye symptoms in patients at high risk for developing LASIK-associated dry eye.
authors.affiliation: Department of Ophthalmology, Military Medical Academy, 5, Klinicheskaya St, St. Petersburg, 194044, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Ma'ltsev
authors.affiliation: Department of Ophthalmology, Military Medical Academy, 5, Klinicheskaya St, St. Petersburg, 194044, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Kudryashova