title: Chest CT abnormalities and quality of life: relationship in adult cystic fibrosis.
abstract: BACKGROUND
  To evaluate the relationship between lung parenchymal abnormalities on chest CT and health-related quality of life in adult cystic fibrosis (CF).
  
  
  METHODS
  The chest CT scans of 101 consecutive CF adults (mean age 27.8±7.9, 64 males) were prospectively scored by two blinded radiologists in consensus using a modified Bhalla score. Health-related quality of life was assessed using the revised Quittner Cystic Fibrosis Questionnaire (CFQ-R). Multiple regressions were performed with each of the CFQ-R domains and all clinical and imaging findings to assess independent correlations.
  
  
  RESULTS
  There were 18 inpatients and 83 outpatients. For the cohort of inpatients, CT abnormalities were significantly (P<0.005 for all) associated with Respiratory Symptoms (Air Trapping), and also with Social Functioning (Consolidation) and Role Functioning (Consolidation). For outpatients, CT abnormalities were significantly (P<0.005 for all) associated with Respiratory Symptoms (Consolidation) and also with Physical Functioning (Consolidation), Vitality (Consolidation, Severity of Bronchiectasis), Eating Problems (airway wall thickening), Treatment Burden (Total CT Score), Body Image (Severity of Bronchiectasis) and Role Functioning (Tree-in-bud nodules). Consolidation was the commonest independent CT predictor for both inpatients (predictor for 2 domains) and outpatients (predictor in 3 domains). Several chest CT abnormalities excluded traditional measures such as FEV1 and BMI from the majority of CFQ-R domains.
  
  
  CONCLUSIONS
  Chest CT abnormalities are significantly associated with quality of life measures in adult CF, independent of clinical or spirometric measurements.
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Aoife
authors.initials: A
authors.lastname: Kilcoyne
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Lisa P
authors.initials: LP
authors.lastname: Lavelle
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Colin J
authors.initials: CJ
authors.lastname: McCarthy
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Sinead H
authors.initials: SH
authors.lastname: McEvoy
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Hannah
authors.initials: H
authors.lastname: Fleming
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Annika
authors.initials: A
authors.lastname: Gallagher
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Martine
authors.initials: M
authors.lastname: Loeve
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Harm
authors.initials: H
authors.lastname: Tiddens
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Edward
authors.initials: E
authors.lastname: McKone
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Gallagher
authors.affiliation: 1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Dodd
keywords: Computed tomography (CT); cystic; fibrosis; pulmonary; quality of life