title: The association between perceived social support and amygdala structure.
abstract: The subjective perception of social support plays a crucial role in human well-being. However, its structural neural substrates remain unknown. We hypothesized that the amygdala, specifically its laterobasal and superficial subregions, which have been suggested to serve social functions, could be associated with the level of perceived social support. To test this hypothesis, we assessed perceived social support using the Multidimensional Scale of Perceived Social Support. In addition, we measured the volume and shape of the amygdala using structural magnetic resonance imaging in 49 healthy participants. Global amygdala volume in the left hemisphere was positively associated with the perceived social support score after adjusting for total cerebral volume, sex, age, intelligence, and five-factor personality domains. The local shape of the laterobasal and superficial subregions of the left amygdala showed the same association with perceived social support. These data suggest that the social subregions of the left amygdala are associated with the implementation of perceived social support.
authors.affiliation: Department of Neurodevelopmental Psychiatry, Habilitation and Rehabilitation, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo, Kyoto 606-8507, Japan. Electronic address: sato.wataru.4v@kyoto-u.ac.jp.
authors.forename: Wataru
authors.initials: W
authors.lastname: Sato
authors.affiliation: Brain Activity Imaging Center, Advanced Telecommunications Research Institute International, 2-2-2 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0288, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Kochiyama
authors.affiliation: Health and Medical Services Center, Shiga University, 1-1-1, Baba, Hikone, Shiga 522-8522, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kubota
authors.affiliation: Department of Neurodevelopmental Psychiatry, Habilitation and Rehabilitation, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo, Kyoto 606-8507, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Uono
authors.affiliation: Department of Neurodevelopmental Psychiatry, Habilitation and Rehabilitation, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo, Kyoto 606-8507, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Sawada
authors.affiliation: Department of Neurodevelopmental Psychiatry, Habilitation and Rehabilitation, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo, Kyoto 606-8507, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yoshimura
authors.affiliation: Faculty of Human Health Science, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan; The Organization for Promoting Neurodevelopmental Disorder Research, 40 Shogoin-Sannocho, Sakyo, Kyoto 606-8392, Japan.
authors.forename: Motomi
authors.initials: M
authors.lastname: Toichi
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000000981:diagnostic imaging* / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D011581:Psychological Tests; D012938:Social Perception; D012944:Social Support; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Amygdala; Laterality; Magnetic resonance imaging (MRI) volumetry; Multidimensional Scale of Perceived Social Support (MSPSS); Perceived social support