title: Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats.
abstract: OBJECTIVE
  The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats.
  
  
  METHODS
  Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extracts were given to rats of different groups as per protocol.
  
  
  RESULTS
  The results data revealed that oral administration of P. amarus extracts had a significant change in pancreatic amylase, lipase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity.
  
  
  CONCLUSIONS
  We concluded that extract of P. amarus possessed chemoprotective activity against azaserine induced pancreatic cancer in Wistar rats.
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India.
authors.forename: Ankit S
authors.initials: AS
authors.lastname: Prajapati
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India.
authors.forename: Sunant K
authors.initials: SK
authors.lastname: Raval
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India.
authors.forename: Suprita
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India.
authors.forename: Tapan N
authors.initials: TN
authors.lastname: Varia
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India.
authors.forename: Parimal H
authors.initials: PH
authors.lastname: Mashiyava
keywords: Phyllanthus amarus; Wistar rat; azaserine; pancreatic cancer; serum biochemistry