title: Morphological Substrates for Parallel Streams of Corticogeniculate Feedback Originating in Both V1 and V2 of the Macaque Monkey.
abstract: Corticothalamic circuits are essential for reciprocal information exchange between the thalamus and cerebral cortex. Nevertheless, the role of corticothalamic circuits in sensory processing remains a mystery. In the visual system, afferents from retina to the lateral geniculate nucleus (LGN) and from LGN to primary visual cortex (V1) are organized into functionally distinct parallel processing streams. Physiological evidence suggests corticogeniculate feedback may be organized into parallel streams; however, little is known about the diversity of corticogeniculate neurons, their local computations, or the structure-function relationship among corticogeniculate neurons. We used a virus-mediated approach to label and reconstruct the complete dendritic and local axonal arbors of identified corticogeniculate neurons in the macaque monkey. Our results reveal morphological substrates for parallel streams of corticogeniculate feedback based on distinct classes of neurons in V1 and V2. These results support the hypothesis that distinct populations of feedback neurons provide independent and unique information to the LGN.
authors.affiliation: Physiology & Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA. Electronic address: farran.briggs@dartmouth.edu.
authors.forename: Farran
authors.initials: F
authors.lastname: Briggs
authors.affiliation: Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA.
authors.forename: Caitlin W
authors.initials: CW
authors.lastname: Kiley
authors.affiliation: Systems Neurobiology Laboratories, Salk Institute for Biological Sciences, La Jolla, CA 92037, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Callaway
authors.affiliation: Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA.
authors.forename: W Martin
authors.initials: WM
authors.lastname: Usrey
mesh_terms: D000818:Animals; D056228:Feedback, Sensory / Q000502:physiology*; D005829:Geniculate Bodies / Q000166:cytology / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010775:Photic Stimulation; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology