title: Arsenic and dichlorvos: Possible interaction between two environmental contaminants.
abstract: Metals are ubiquitously present in the environment and pesticides are widely used throughout the world. Environmental and occupational exposure to metal along with pesticide is an area of great concern to both the public and regulatory authorities. Our major concern is that combination of these toxicant present in environment may elicit toxicity either due to additive or synergistic interactions or 'joint toxic actions' among these toxicants. It poses a rising threat to human health. Water contamination particularly ground water contamination with arsenic is a serious problem in today's scenario since arsenic is associated with several kinds of health problems, such arsenic associated health anomalies are commonly called as 'Arsenism'. Uncontrolled use and spillage of pesticides into the environment has resulted in alarming situation. Moreover serious concerns are being addressed due to their persistence in the environmental matrices such as air, soil and surface water runoff resulting in continuous exposure of these harmful chemicals to human beings and animals. Bio-availability of these environmental toxicants has been enhanced much due to anthropological activities. Dreadfully very few studies are available on combined exposures to these toxicants on the animal or human system. Studies on the acute and chronic exposure to arsenic and DDVP are well reported and well defined. Arsenic is a common global ground water contaminant while dichlorvos is one of the most commonly and widely employed organophosphate based insecticide used in agriculture, horticulture etc. There is thus a real situation where a human may get exposed to these toxicants while working in a field. This review highlights the individual and combined exposure to arsenic and dichlorvos on health.
authors.affiliation: Division of Regulatory Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India. Electronic address: sjsflora@hotmail.com.
authors.forename: Swaran J S
authors.initials: SJ
authors.lastname: Flora
mesh_terms: D001151:Arsenic / Q000493:pharmacokinetics / Q000633:toxicity*; D015415:Biomarkers / Q000032:analysis; D004006:Dichlorvos / Q000493:pharmacokinetics / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D008670:Metals / Q000633:toxicity; D010575:Pesticides / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D008670:Metals; D010575:Pesticides; D004006:Dichlorvos; D001151:Arsenic
keywords: Arsenic; Biochemical effects; Dichlorvos; Interaction; Organ damage; Preventive and therapeutic measure; Toxicity