title: Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control.
abstract: Mitochondria are essential organelles for many fundamental cellular processes, including energy production, fatty acid β-oxidation, metabolite synthesis, iron and calcium homeostasis, and programmed cell death. Mitochondrial quality thus influences not only individual cell functions but also whole body metabolism. Dysregulated mitochondrial quality control is closely associated with the progression of aging related diseases, such as cancers and neurodegenerative disorders. Mitochondrial quality is monitored at the protein, organelle and sub-organelle levels. The critical issues are how stresses such as bioenergetic stress, oxidative stress and proteotoxic stress, are sensed and how the mitochondrial events are coordinated. Recently, several receptors were identified to mediate selective mitophagy, which is essential for mitochondrial quality control in yeast and mammalian cells. It is emerging that these receptors sense distinct stress signals and couple mitophagy machineries with mitochondrial fission/fusion machineries for mitochondrial quality control. Herein, we will review recent advances in receptors mediated mitophagy and mitochondrial dynamics for mitochondrial quality control, with attempt to have an integrative view on the molecular mechanisms for mitochondrial quality control.
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: China-US (Henan) Hormel Cancer Institute, Zhengzhou, China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Department of Biosciences, COMSATS Institute of Information Technology, Sahiwal, Pakistan.
authors.forename: Sheikh Arslan
authors.initials: SA
authors.lastname: Sehgal
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin, China. Electronic address: chenq@ioz.ac.cn.
authors.forename: Quan
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D000071183:Autophagy-Related Proteins / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000378:metabolism* / Q000502:physiology; D063306:Mitophagy; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology
chemical_list: D000071183:Autophagy-Related Proteins; D024101:Mitochondrial Proteins; D018160:Receptors, Cytoplasmic and Nuclear
keywords: Mitochondrial dynamics; Mitochondrial quality control; Mitochondrial stresses; Mitophagy receptor