title: Finding the optimal deconvolution algorithm for MR perfusion in carotid stenosis: Correlations with angiographic cerebral circulation time.
abstract: OBJECTIVE
  The aim of our study is to explore the impacts of different deconvolution algorithms on correlations between CBF, MTT, CBV, TTP, Tmax from MR perfusion (MRP) and angiography cerebral circulation time (CCT).
  
  
  METHODS
  Retrospectively, 30 patients with unilateral carotid stenosis, and available pre-stenting MRP and angiography were included for analysis. All MRPs were conducted in a 1.5-T MR scanner. Standard singular value decomposition, block-circulant, and two delay-corrected algorithms were used as the deconvolution methods. All angiographies were obtained in the same bi-plane flat-detector angiographic machine. A contrast bolus of 12mL was administrated via angiocatheter at a rate of 8mL/s. The acquisition protocols were the same for all cases. CCT was defined as the difference between time to peak from the cavernous ICA and the parietal vein in lateral view. Pearson correlations were calculated for CCT and CBF, MTT, CBV, TTP, Tmax.
  
  
  RESULTS
  The correlation between CCT and MTT was highest with Tmax (r=0.65), followed by MTT (r=0.60), CBF (r=-0.57), and TTP (r=0.33) when standard singular value decomposition was used. No correlation with CBV was noted.
  
  
  CONCLUSIONS
  MRP using a singular value decomposition algorithm confirmed the feasibility of quantifying cerebral blood flow deficit in steno-occlusive disease within the angio-room. This approach might further improve patient safety by providing immediate cerebral hemodynamics without extraradiation and iodine contrast.
authors.affiliation: Department of radiology, Taipei Veterans general hospital, 201, Shipai Road, Section 2, 11217 Taipei, Taiwan; School of medicine, National Yang Ming university, Taipei, Taiwan.
authors.forename: Chung-Jung
authors.initials: CJ
authors.lastname: Lin
authors.affiliation: Department of radiology, Taipei Veterans general hospital, 201, Shipai Road, Section 2, 11217 Taipei, Taiwan; School of medicine, National Yang Ming university, Taipei, Taiwan.
authors.forename: Sheng-Che
authors.initials: SC
authors.lastname: Hung
authors.affiliation: Department of radiology, Taipei Veterans general hospital, 201, Shipai Road, Section 2, 11217 Taipei, Taiwan; School of medicine, National Yang Ming university, Taipei, Taiwan.
authors.forename: Feng-Chi
authors.initials: FC
authors.lastname: Chang
authors.affiliation: Department of radiology, Taipei Veterans general hospital, 201, Shipai Road, Section 2, 11217 Taipei, Taiwan; School of medicine, National Yang Ming university, Taipei, Taiwan. Electronic address: wyguo@vghtpe.gov.tw.
authors.forename: Wan-Yuo
authors.initials: WY
authors.lastname: Guo
authors.affiliation: Department of radiology, Taipei Veterans general hospital, 201, Shipai Road, Section 2, 11217 Taipei, Taiwan; School of medicine, National Yang Ming university, Taipei, Taiwan.
authors.forename: Chao-Bao
authors.initials: CB
authors.lastname: Luo
authors.affiliation: Siemens AG, healthcare sector, angiography and interventional X-Ray systems, Forchheim, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Kowarschik
authors.affiliation: Department of radiology, Taipei Veterans general hospital, 201, Shipai Road, Section 2, 11217 Taipei, Taiwan; School of medicine, National Yang Ming university, Taipei, Taiwan.
authors.forename: Wei-Fa
authors.initials: WF
authors.lastname: Chu
authors.affiliation: Department of radiology, Taipei Veterans general hospital, 201, Shipai Road, Section 2, 11217 Taipei, Taiwan; School of medicine, National Yang Ming university, Taipei, Taiwan.
authors.forename: Adrian J Y Kang
authors.initials: AJ
authors.lastname: Liou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D002533:Cerebral Angiography / Q000379:methods; D003287:Contrast Media / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media
keywords: Carotid stenosis; Cerebral blood flow; Cerebral circulation time; Deconvolution algorithm; MR perfusion; Quantitative DSA; Time density curve