title: Polyomaviruses BK, JC, KI, WU, MC, and TS in children with allogeneic hematopoietic stem cell transplantation.
abstract: Timely and reliable detection of viruses is of key importance in early diagnosis of infection(s) following allogeneic HSCT. Among the immunocompetent, infections with BKPyV and JCPyV are mostly subclinical, while post-HSCT, the former may cause HC and the latter PML. The epidemiology and clinical impact of the newly identified KIPyV, WUPyV, MCPyV, and TSPyV in this context remain to be defined. To assess the incidence and clinical impact of BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, and TSPyV infections, we performed longitudinal molecular surveillance for DNAemias of these HPyVs among 53 pediatric HSCT recipients. Surveillance pre-HSCT and for three months post-HSCT revealed BKPyV DNAemia in 20 (38%) patients. Our data demonstrate frequent BKPyV DNAemia among pediatric patients with HSCT and the confinement of clinical symptoms to high copy numbers alone. MCPyV and JCPyV viremias occurred at low and TSPyV viremia at very low prevalences. KIPyV or WUPyV viremias were not demonstrable in this group of immunocompromised patients.
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki, Helsinki, Finland.|Department of Pediatrics, Porvoo Hospital, Porvoo, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Rahiala
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki, Helsinki, Finland.|Department of Pediatrics, Turku University Hospital, Turku, Finland.
authors.forename: Minna
authors.initials: M
authors.lastname: Koskenvuo
authors.affiliation: Department of Virology, University of Helsinki, Helsinki, Finland.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Sadeghi
authors.affiliation: Division of Microbiology and Genetics, Department of Clinical Virology, Turku University Hospital, Turku, Finland.|Department of Virology, University of Turku, Turku, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Waris
authors.affiliation: Division of Microbiology and Genetics, Department of Clinical Virology, Turku University Hospital, Turku, Finland.|Department of Virology, University of Turku, Turku, Finland.
authors.forename: Tytti
authors.initials: T
authors.lastname: Vuorinen
authors.affiliation: Department of Virology and Immunology, Helsinki University Hospital Laboratory Services (HUSLAB), Helsinki, Finland.
authors.forename: Maija
authors.initials: M
authors.lastname: Lappalainen
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki, Helsinki, Finland.
authors.forename: Ulla
authors.initials: U
authors.lastname: Saarinen-Pihkala
authors.affiliation: Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Tobias
authors.initials: T
authors.lastname: Allander
authors.affiliation: Department of Virology, University of Helsinki, Helsinki, Finland.
authors.forename: Maria
authors.initials: M
authors.lastname: Söderlund-Venermo
authors.affiliation: Department of Virology, University of Helsinki, Helsinki, Finland.|Department of Virology and Immunology, Helsinki University Hospital Laboratory Services (HUSLAB), Helsinki, Finland.
authors.forename: Klaus
authors.initials: K
authors.lastname: Hedman
authors.affiliation: Department of Pediatrics, Turku University Hospital, Turku, Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Ruuskanen
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki, Helsinki, Finland.
authors.forename: Kim
authors.initials: K
authors.lastname: Vettenranta
mesh_terms: D001739:BK Virus; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007223:Infant; D007577:JC Virus; D007938:Leukemia / Q000628:therapy*; D008297:Male; D010351:Patient Discharge; D011120:Polyomavirus; D027601:Polyomavirus Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D015995:Prevalence; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D014766:Viremia; D055815:Young Adult
keywords: childhood; hematopoietic stem cell transplantation; hemorrhagic cystitis; polyomavirus