title: The Role of ANK in Calcium Pyrophosphate Deposition Disease.
abstract: The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. Much about the structure, function, and regulation of ANK remain unstudied. This review of the current literature examines recent contributions to our understanding of ANK. We focus on new work on the function, binding partners, and regulators of ANK. A more complete understanding of this important protein may help to identify future therapeutic targets for the treatment of calcium pyrophosphate deposition disease.
authors.affiliation: The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Mitton-Fitzgerald
authors.affiliation: The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA. cgohr@mcw.edu.
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Gohr
authors.affiliation: The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Bettendorf
authors.affiliation: The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA.
authors.forename: Ann K
authors.initials: AK
authors.lastname: Rosenthal
mesh_terms: D002805:Chondrocalcinosis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D028061:Phosphate Transport Proteins / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: C498770:ANKH protein, human; D028061:Phosphate Transport Proteins
keywords: ANK; ANKH; Calcium pyrophosphate; Chondrocalcinosis; Progressive ankylosis gene; Pseudogout