title: Retrospective evaluation of toceranib phosphate (Palladia®) toxicity in cats.
abstract: The purpose of this study was to describe the toxicity profile of toceranib phosphate in tumour bearing cats. Medical records were reviewed from seven institutions. Patients with incomplete medical records and those receiving concurrent chemotherapy or NSAIDs (non-steroidal anti-inflammatory) were excluded. Fifty-five cats met the inclusion criteria. Carcinoma was diagnosed in 55% of cases. Median oral toceranib dose was 2.7 mg kg-1and was most commonly administered on Monday, Wednesday and Friday. Thrombocytopenia (16.3%) and neutropenia (9.1%) were the most common haematologic toxicities. Azotemia (14.5%) and alanine aminotransferase (ALT) elevations (7.2%) were the most frequently encountered biochemical alterations. Gastrointestinal (GI) toxicity was seen in 21.8% of cats, and was lower than previously reported in dogs. The results of this study showed that treatment of cats with toceranib is well-tolerated and toxicity is uncommon. Additional studies to define a more structured dosing schedule and to evaluate the efficacy of toceranib in the treatment of feline cancers are needed.
authors.affiliation: VCA Bay Area Veterinary Specialists & Emergency Hospital, San Leandro, CA, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Merrick
authors.affiliation: Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Pierro
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Schleis
authors.affiliation: Animal Cancer Care Clinic, Ft. Lauderdale, FL, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Sones
authors.affiliation: VCA Animal Diagnostic Clinic, Dallas, TX, USA.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Wright
authors.affiliation: Blue Pearl Georgia Veterinary Specialists, Sandy Springs, GA, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Regan
authors.affiliation: VCA Bay Area Veterinary Specialists & Emergency Hospital, San Leandro, CA, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Siedlecki
authors.affiliation: Department of VCA Clinical Studies, VCA Katonah Bedford Veterinary Center, Bedford Hills, NY, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Bergman
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D053099:Azotemia / Q000139:chemically induced / Q000662:veterinary; D002371:Cat Diseases / Q000188:drug therapy; D002415:Cats; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects; D007211:Indoles / Q000627:therapeutic use / Q000633:toxicity*; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary; D009503:Neutropenia / Q000139:chemically induced / Q000662:veterinary; D011758:Pyrroles / Q000627:therapeutic use / Q000633:toxicity*; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000139:chemically induced / Q000662:veterinary
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; C464577:toceranib phosphate; D000410:Alanine Transaminase
keywords: Palladia; cancer; feline; toceranib; toxicity