title: Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity.
abstract: Obesity is associated with vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyvitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on vitamin D concentrations in a NHP population. These data underline the importance of adequate vitamin D supplementation in obese animals.
authors.affiliation: Texas Tech University HSC School of Medicine at the Permian Basin, Odessa, Texas, USA. Natalia.schlabritz-lutsevich@ttuhsc.edu.
authors.forename: Natalia E
authors.initials: NE
authors.lastname: Schlabritz-Loutsevitch
authors.affiliation: Departments of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
authors.affiliation: The University of Texas Rio Grande Valley, Brownsville, Texas, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Mahaney
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Gene B
authors.initials: GB
authors.lastname: Hubbard
authors.affiliation: Departments of Pathology, Texas Biomedical Research Institute, San Antonio, Texas, USA.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Dick
authors.affiliation: Division of Biostatistics, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, USA.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kocak
authors.affiliation: Department of Obstetrics and Gynecology; University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Sonali
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Texas Tech University HSC School of Medicine at the Permian Basin, Odessa, Texas.
authors.forename: Maira
authors.initials: M
authors.lastname: Carrillo
authors.affiliation: Department of Obstetrics and Gynecology; University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Mauro
authors.initials: M
authors.lastname: Schenone
authors.affiliation: Division of Connective Tissue Diseases, Department of Medicine, University of Tennessee Health Science Center, and Department of Veterans Affairs Medical Center, Memphis, Tennessee, USA.
authors.forename: Arnold
authors.initials: A
authors.lastname: Postlethwaite
authors.affiliation: Department of Dermatology and Pathology, VA Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Slominski
mesh_terms: D000818:Animals; D005260:Female; D006799:Housing, Animal; D006801:Humans; D023421:Models, Animal; D009765:Obesity / Q000097:blood*; D010215:Papio; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood; D014815:Vitamins / Q000097:blood* / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D