title: Evaluation of platelet-rich plasma alone or in combination with demineralized freeze dried bone allograft in treatment of periodontal infrabony defects: A comparative clinical trial.
abstract: OBJECTIVE
  The use of platelet-rich plasma (PRP) alone in periodontal defects has been controversial and inconclusive. Hence, the present study was designed with the aim to assess the clinical and radiographic effectiveness of PRP alone in infrabony defects.
  
  
  METHODS
  Thirty infrabony defects were treated with either autologous PRP with open flap debridement (OFD) or autologous PRP + demineralized freeze dried bone graft (DFDBA) with OFD or OFD alone. Clinical parameters recorded were gingival index, plaque index, probing depth (PD), clinical attachment level (CAL), and gingival recession (REC). Radiographic parameters included defect depth reduction, defect resolution, and crestal bone level. All the parameters were recorded at baseline and 12 months postoperatively.
  
  
  RESULTS
  Mean PD reduction and CAL gain were greater in PRP + DFDBA (4.88 ± 1.12 mm and 4.26 ± 1.85 mm) and PRP (4.86 ± 2.12 mm and 4.10 ± 1.47 mm) groups than the control group (2.69 ± 1.37 mm and 1.27 ± 0.89 mm).
  
  
  CONCLUSIONS
  Within the limits of the study, all the three groups showed significant improvement in clinical parameters from baseline to postoperative 12 months. The amount of defect depth reduction and defect resolution treated with PRP alone group were significantly < PRP + DFDBA. The results pertaining to these parameters were significantly better than the control group.
authors.affiliation: Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
authors.forename: Prerna
authors.initials: P
authors.lastname: Agarwal
authors.affiliation: Department of Periodontology and Implantology, Oxford Dental College, Bengaluru, Karnataka, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Chatterjee
authors.affiliation: Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
authors.forename: Shankar
authors.initials: S
authors.lastname: Gokhale
authors.affiliation: Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
authors.forename: Himanshu Pratap
authors.initials: HP
authors.lastname: Singh
authors.affiliation: Department of Dentistry, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Kandwal
keywords: Demineralized freeze-dried bone graft; infrabony defects; platelet-rich plasma; regeneration