title: Doa1 is a MAD adaptor for Cdc48.
abstract: Dislocation of polypeptides from the mitochondrial outer membrane by the p97/Cdc48-Ufd1-Npl4 adenosine triphosphatase complex is essential for mitochondria-associated degradation and Parkin-mediated mitophagy. In this issue, Wu et al. (2016.J. Cell Biol.http://dx.doi.org/10.1083/jcb.201510098) identify Doa1 as a pivotal adaptor that recruits substrates to Cdc48 for processing.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 yihongy@mail.nih.gov.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Ye
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D010455:Peptides / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D010455:Peptides; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases