title: The interplay between regulated necrosis and bacterial infection.
abstract: Necrosis has long been considered as a passive event resulting from a cell extrinsic stimulus, such as pathogen infection. Recent advances have refined this view and it is now well established that necrosis is tightly regulated at the cell level. Regulated necrosis can occur in the context of host-pathogen interactions, and can either participate in the control of infection or favor it. Here, we review the two main pathways implicated so far in bacteria-associated regulated necrosis: caspase 1-dependent pyroptosis and RIPK1/RIPK3-dependent necroptosis. We present how these pathways are modulated in the context of infection by a series of model bacterial pathogens.
authors.affiliation: Institut Pasteur, Biology of Infection Unit, 75015, Paris, France.|U1117, Inserm, 75015, Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Blériot
authors.affiliation: Institut Pasteur, Biology of Infection Unit, 75015, Paris, France. marc.lecuit@pasteur.fr.|U1117, Inserm, 75015, Paris, France. marc.lecuit@pasteur.fr.|French National Reference Center and World Health Organization Collaborating Centre on Listeria, Institut Pasteur, 75015, Paris, France. marc.lecuit@pasteur.fr.|Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, Division of Infectious Diseases and Tropical Medicine, Necker-Pasteur Centre for Infectiology, Necker-Enfants Malades University Hospital, 75015, Paris, France. marc.lecuit@pasteur.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000473:pathology*; D020170:Caspase 1 / Q000378:metabolism*; D004405:Dysentery, Bacillary / Q000473:pathology; D054884:Host-Pathogen Interactions; D006801:Humans; D008088:Listeriosis / Q000473:pathology; D051379:Mice; D009336:Necrosis / Q000473:pathology*; D000069292:Pyroptosis / Q000502:physiology*; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*; D012480:Salmonella Infections / Q000473:pathology; D014376:Tuberculosis / Q000473:pathology; D015009:Yersinia Infections / Q000473:pathology
chemical_list: C506249:RIPK1 protein, human; C119705:RIPK3 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; D020170:Caspase 1
keywords: Bacteria; Cell death; Regulated necrosis