title: [The association between the 5-HTTLPR polymorphism of the serotonin transporter gene and the efficacy and tolerability of selective serotonin reuptake inhibitors].
abstract: OBJECTIVE
  To search for the association between the 5-HTTLPR polymorphism of the serotonin transporter gene and the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs).
  
  
  METHODS
  The complex clinical/psychopathological and genetic study of 38 patients with depression treated with SSRIs was carried out.
  
  
  CONCLUSIONS
  The 5-HTTLPR polymorphism was associated with the rate of achievement of remission and tolerability of treatment: carriers of the SS genotype achieved remission less frequently and more frequently experienced side-effects.
authors.affiliation: Kafedra psihiatrii i narkologii GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva; nauchno-issledovatel'skij otdel psihicheskogo zdorov'ja GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: N N
authors.initials: NN
authors.lastname: Ivanets
authors.affiliation: Kafedra psihiatrii i narkologii GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva; nauchno-issledovatel'skij otdel psihicheskogo zdorov'ja GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: M A
authors.initials: MA
authors.lastname: Kinkulkina
authors.affiliation: Kafedra psihiatrii i narkologii GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva; nauchno-issledovatel'skij otdel psihicheskogo zdorov'ja GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: Yu G
authors.initials: YG
authors.lastname: Tikhonova
authors.affiliation: Kafedra psihiatrii i narkologii GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: T I
authors.initials: TI
authors.lastname: Avdeeva
authors.affiliation: tsentr kollektivnogo pol'zovanija 'Transfuzionnaja meditsina' GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: A A
authors.initials: AA
authors.lastname: Ragimov
authors.affiliation: tsentr kollektivnogo pol'zovanija 'Transfuzionnaja meditsina' GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: N G
authors.initials: NG
authors.lastname: Dashkova
authors.affiliation: tsentr kollektivnogo pol'zovanija 'Transfuzionnaja meditsina' GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: O E
authors.initials: OE
authors.lastname: Kuznetsov
authors.affiliation: tsentr kollektivnogo pol'zovanija 'Transfuzionnaja meditsina' GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: A V
authors.initials: AV
authors.lastname: Matveev
authors.affiliation: nauchno-issledovatel'skij otdel psihicheskogo zdorov'ja GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
authors.forename: T A
authors.initials: TA
authors.lastname: Iziumina
authors.affiliation: FGBU 'Nauchnyj tsentr nevrologii' RAN, Moskva.
authors.forename: S V
authors.initials: SV
authors.lastname: Orlov
mesh_terms: D000328:Adult; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071184:Pharmacogenomic Variants; D011446:Prospective Studies; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors