title: Abacavir-induced liver toxicity.
abstract: Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir discontinuation in a cohort of patients treated with abacavir-lamivudine-nevirapine.
authors.affiliation: Università di Milano, Luigi Sacco University Hospital, Department of Biomedical and Clinical Sciences L. Sacco, Milan, Italy.
authors.forename: Maria Diletta
authors.initials: MD
authors.lastname: Pezzani
authors.affiliation: Università di Milano, Luigi Sacco University Hospital, Department of Biomedical and Clinical Sciences L. Sacco, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Resnati
authors.affiliation: Università di Milano, Luigi Sacco University Hospital, Department of Biomedical and Clinical Sciences L. Sacco, Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Di Cristo
authors.affiliation: Università di Milano, Luigi Sacco University Hospital, Department of Infectious Diseases, Milan, Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Riva
authors.affiliation: Università di Milano, Luigi Sacco University Hospital, Department of Infectious Diseases, Milan, Italy. Electronic address: cristina.gervasoni@unimi.it.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gervasoni
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D015224:Dideoxynucleosides / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D015235:HLA-B Antigens / Q000276:immunology; D006801:Humans; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen
keywords: Abacavir; HIV; Liver toxicity