title: Radioresistance of Brain Tumors.
abstract: Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells would be beneficial. In this review, we focus on radioresistance mechanisms intrinsic to tumor cells. We also evaluate existing approaches to induce radiosensitization and explore future avenues of investigation.
authors.affiliation: Radiation Medicine Department, Hofstra Northwell School of Medicine, Northwell Health, Manhasset, NY 11030, USA. kkelley1@northwell.edu.
authors.forename: Kevin
authors.initials: K
authors.lastname: Kelley
authors.affiliation: Radiation Medicine Department, Hofstra Northwell School of Medicine, Northwell Health, Manhasset, NY 11030, USA. jknisely@northwell.edu.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Knisely
authors.affiliation: The Feinstein Institute for Molecular Medicine, Hofstra Northwell School of Medicine, Northwell Health, Manhasset, NY 11030, USA. msymons@northwell.edu.
authors.forename: Marc
authors.initials: M
authors.lastname: Symons
authors.affiliation: Radiation Medicine Department, Hofstra Northwell School of Medicine, Northwell Health, Manhasset, NY 11030, USA. mruggier@northwell.edu.|The Feinstein Institute for Molecular Medicine, Hofstra Northwell School of Medicine, Northwell Health, Manhasset, NY 11030, USA. mruggier@northwell.edu.
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Ruggieri
keywords: brain tumors; radiation therapy; radioresistance