title: Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili.
abstract: Genome-wide analysis demonstrates extensive genomic adaptive complexes involved in sympatric speciation between blind mole rats (Spalax galili) in abutting populations living in basalt and chalk soils. Among the gene ontology (GO) enrichment, musculature and metabolism stood out in basalt dwellers while nutrition and neurogenetics were highlighted in chalk residents. Measurements of mechanisms regulating protein homeostasis inspired by these GO terms suggest that at the proteomic level there is also a habitat/soil-type driven divergence with the basalt residents exhibiting higher proteasome activity whereas elevated levels of markers of autophagy are evident in the chalk inhabitants.
authors.affiliation: a Sam and Anne Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio (UTHSCSA) , San Antonio , TX , USA.|b Department of Physiology , UTHSCSA , San Antonio , TX , USA.
authors.forename: Karl A
authors.initials: KA
authors.lastname: Rodriguez
authors.affiliation: c Institute of Evolution, University of Haifa , Haifa , Israel.|d Department of Ecology , College of Life Sciences, Wuhan University , Wuhan , China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Li
authors.affiliation: c Institute of Evolution, University of Haifa , Haifa , Israel.
authors.forename: Eviatar
authors.initials: E
authors.lastname: Nevo
authors.affiliation: a Sam and Anne Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio (UTHSCSA) , San Antonio , TX , USA.|b Department of Physiology , UTHSCSA , San Antonio , TX , USA.|e Calico ; San Francisco , CA , USA.
authors.forename: Rochelle
authors.initials: R
authors.lastname: Buffenstein
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D063990:Gene Ontology; D049810:Genetic Speciation; D006706:Homeostasis; D011506:Proteins / Q000378:metabolism*; D059748:Proteolysis; D046308:Spalax / Q000378:metabolism*; D061350:Sympatry
chemical_list: D011506:Proteins
keywords: 20S proteasome; ATG7; autophagic flux; ecological speciation; protein homeostasis