title: Membrane Lipids in Presynaptic Function and Disease.
abstract: Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism are associated with many neuronal diseases. Here, we discuss recent advances in understanding presynaptic membrane lipid organization, centered on illustrative examples of how the lipids themselves regulate membrane trafficking and control protein activity. This insight highlights that presynaptic terminals are membrane-remodeling machines and that cooperation between lipid and protein molecules underlies presynaptic activity.
authors.affiliation: Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, Leuven Institute for Neurodegenerative Disease, Herestraat 49, Bus 602, 3000 Leuven, Belgium. Electronic address: elsa.lauwers@cme.vib-kuleuven.be.
authors.forename: Elsa
authors.initials: E
authors.lastname: Lauwers
authors.affiliation: Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, Leuven Institute for Neurodegenerative Disease, Herestraat 49, Bus 602, 3000 Leuven, Belgium. Electronic address: rose.goodchild@cme.vib-kuleuven.be.
authors.forename: Rose
authors.initials: R
authors.lastname: Goodchild
authors.affiliation: Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, Leuven Institute for Neurodegenerative Disease, Herestraat 49, Bus 602, 3000 Leuven, Belgium. Electronic address: patrik.verstreken@cme.vib-kuleuven.be.
authors.forename: Patrik
authors.initials: P
authors.lastname: Verstreken
mesh_terms: D000818:Animals; D001714:Bipolar Disorder / Q000235:genetics / Q000378:metabolism; D004705:Endocytosis; D005089:Exocytosis; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism*; D021381:Protein Transport; D050600:SNARE Proteins / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D008563:Membrane Lipids; D008565:Membrane Proteins; D018377:Neurotransmitter Agents; D010716:Phosphatidylinositols; D050600:SNARE Proteins