title: Difference in the Surgical Outcome of Unilateral Cleft Lip and Palate Patients with and without Pre-Alveolar Bone Graft Orthodontic Treatment.
abstract: Presurgical orthodontic treatment before secondary alveolar bone grafting (SABG) is widely performed for cleft lip/palate patients. However, no randomized controlled trial has been published comparing SABG outcomes in patients with, and without, presurgical orthodontic treatment. This randomized, prospective, single-blinded trial was conducted between January 2012 and April 2015 to compare ABG volumes 6 months postoperatively between patients with and without presurgical orthodontic treatment. Twenty-four patients were enrolled and randomized and 22 patients completed follow-up. Patients who had presurgical orthodontics before SABG had significantly improved inclination (p < 0.001) and rotation (p < 0.001) of the central incisor adjacent to the defect, significantly improved ABG fill volume (0.81 ± 0.26 cm(3) at 6 months compared to 0.59 ± 0.22 cm(3); p < 0.05) and less residual alveolar bone defect (0.31 ± 0.08 cm(3) at 6 months compared to s 0.55 ± 0.14 cm(3); p < 0.001) compared to patients who did not have presurgical orthodontic treatment. In conclusion, orthodontic treatment combined with SABG results in superior bone volume when compared with conventional SABG alone.
authors.affiliation: Department of Chemical and Materials Engineering, College of Engineering, Chang Gung University, Taoyuan, Taiwan.|Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Chun-Shin
authors.initials: CS
authors.lastname: Chang
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Christopher Glenn
authors.initials: CG
authors.lastname: Wallace
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Yen-Chang
authors.initials: YC
authors.lastname: Hsiao
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Chiu
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Betty Chien-Jung
authors.initials: BC
authors.lastname: Pai
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: I-Ju
authors.initials: IJ
authors.lastname: Chen
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Liao
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Eric Jen-Wein
authors.initials: EJ
authors.lastname: Liou
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Philip Kuo-Ting
authors.initials: PK
authors.lastname: Chen
authors.affiliation: Department of Chemical and Materials Engineering, College of Engineering, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Jyh-Ping
authors.initials: JP
authors.lastname: Chen
authors.affiliation: Craniofacial Research Center, Department of Medical Research, Department of Plastic &Reconstructive Surgery and Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: M Samuel
authors.initials: MS
authors.lastname: Noordhoff
mesh_terms: D064728:Alveolar Bone Grafting / Q000379:methods*; D002648:Child; D002971:Cleft Lip / Q000000981:diagnostic imaging / Q000601:surgery*; D002972:Cleft Palate / Q000000981:diagnostic imaging / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009971:Orthodontics, Corrective / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D016896:Treatment Outcome