title: Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome.
abstract: Epilepsy in Angelman Syndrome is thought to originate from an imbalance between local excitatory-inhibitory circuits that results in a generalized hyperexcitability. In this issue of Neuron, Judson et al. (2016) demonstrate that selective maternal deletion of Ube3a in cortical GABAergic neurons causes circuit hyperexcitability, increased seizure severity, and EEG abnormalities.
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Santini
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: ek65@nyu.edu.
authors.forename: Eric
authors.initials: E
authors.lastname: Klann
mesh_terms: D017204:Angelman Syndrome / Q000235:genetics*; D000818:Animals; D004827:Epilepsy / Q000235:genetics*; D059330:GABAergic Neurons / Q000378:metabolism*; D019579:Neocortex / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism*; D012640:Seizures / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D044767:Ubiquitin-Protein Ligases