title: A retrospective analysis of possible triggers of Guillain-Barre syndrome.
abstract: Antecedent infections have been found to be the most common trigger for Guillain-Barre syndrome (GBS). In the present study, we retrospectively analyzed 36 adult patients with GBS and found that surgery, trauma and treatment with ganglioside were also common before the onset of GBS. The proportion of the axonal subtype of GBS in post-surgical/traumatic patients was higher than that in non-surgical/traumatic patients (P=0.013) in the present study. In conclusion, this study has shown that prior infection, surgery, trauma and ganglioside may be clinical contributors to the onset of GBS and raised the possibility that they may act synergistically as triggers for the development of GBS.
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Case Administration, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lian
authors.affiliation: Department of Electromyography, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Electromyography, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
authors.forename: Bing-Yun
authors.initials: BY
authors.lastname: Wu
authors.affiliation: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China. Electronic address: ruisheng_duan@yahoo.com.
authors.forename: Rui-Sheng
authors.initials: RS
authors.lastname: Duan
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000150:complications*; D016009:Chi-Square Distribution; D004576:Electromyography; D005260:Female; D005732:Gangliosides / Q000009:adverse effects* / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D011183:Postoperative Complications / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005732:Gangliosides
keywords: Ganglioside; Guillain–Barre syndrome; Infection; Surgery; Trauma