title: [PECULIARITIES OF THE MESENTERY MICROCIRCULATORY BED RESPONSE TO ISONIAZID INTOXICATION].
abstract: An original technique has been developed for the biomicroscopy of small-intestine mesentery blood vessels in rats. Using this method, specific features of mic- rocirculatory process disturbances caused by isoniazid in high doses have been elucidated for the first time. It is established that intragastric introduction of iso- niazid (single daily dose of 542 mg/kg for 6 days) leads to pronounced disturbances of the microcirculatory process, accompanied by intravascular aggregation of erythrocytes, stasis, destructive changes in vessel walls, diapedesis, and hemorrhage over an area of (1.9-9.9) x 10⁻³ mm².
authors.forename: E N
authors.initials: EN
authors.lastname: Muzalevskaya
authors.forename: V A
authors.initials: VA
authors.lastname: Nikolaevskii
authors.forename: Yu N
authors.initials: YN
authors.lastname: Chernov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D004903:Erythrocyte Aggregation / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000473:pathology; D018589:Gastroparesis / Q000139:chemically induced / Q000473:pathology; D007421:Intestine, Small / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D007538:Isoniazid / Q000633:toxicity*; D008297:Male; D008643:Mesentery / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008833:Microcirculation / Q000187:drug effects*; D008853:Microscopy; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D057705:Transendothelial and Transepithelial Migration / Q000187:drug effects
chemical_list: D007538:Isoniazid