title: Association of Abdominal Circumference, Body Mass Index, and Inflammation in Kidney Transplant Recipients.
abstract: Increased abdominal circumference is a marker of obesity, and it is associated with increased mortality in renal transplant recipients. Recent findings suggest that increased visceral fat deposition is a modifier of inflammation. However, little is known about the association of inflammation with abdominal circumference in kidney transplant recipients.
  
  
  
  Cross-sectional.
  
  
  
  We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data from 985 prevalent kidney transplant recipients. Abdominal circumference, body mass index (BMI), and inflammatory markers were measured at baseline. Associations of inflammatory markers with abdominal circumference and BMI were examined in unadjusted and adjusted regression models.
  
  
  
  Mean ± standard deviation age was a 51 ± 13 years, 57% were men, and 21% were diabetics. Patients with abdominal circumference above the median had higher BMI and were older (mean ± standard deviation: 23.9 ± 3.6 vs. 30.1 ± 3.9 kg/m(2), P < .001; and 48 ± 14 vs. 54 ± 11 years, P < .001). Furthermore, patients with higher abdominal circumference had higher inflammatory parameters: median (interquartile range) C-reactive protein (mg/L): 2.3 (3.9) versus 4.1 (6.2), P < .001; and IL-6 (pg/mL): 1.9 (2.2) versus 2.3 (2.4), P < .001. In multivariable-adjusted linear regression models, higher abdominal circumference showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of abdominal circumference for lnCRP: βabdominal circumference = 0.29, P < .001; and for lnIL-6: βabdominal circumference = 0.09, P = .018). Moreover, in multivariable-adjusted linear regression models, higher BMI showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of BMI for lnCRP: βBMI = 0.24, P < .001; and for white blood cells: βBMI = 0.07, P = .041).
  
  
  
  Abdominal circumference and BMI are independently associated with inflammatory markers in prevalent kidney transplant recipients.
authors.affiliation: Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
authors.forename: Kristof
authors.initials: K
authors.lastname: Nagy
authors.affiliation: Department of Pathophysiology, Semmelweis University, Budapest, Hungary.
authors.forename: Akos
authors.initials: A
authors.lastname: Ujszaszi
authors.affiliation: Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
authors.forename: Adam
authors.initials: A
authors.lastname: Remport
authors.affiliation: Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; Department of Medicine, Nephrology Section, Memphis Veterans Affairs Medical Center, Memphis, Tennessee.
authors.forename: Csaba P
authors.initials: CP
authors.lastname: Kovesdy
authors.affiliation: Department of Medicine, Division of Nephrology and Multiorgan Transplant Program, University Health Network and University of Toronto, Toronto, Canada.
authors.forename: Istvan
authors.initials: I
authors.lastname: Mucsi
authors.affiliation: Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address: mzmolnar@uthsc.edu.
authors.forename: Miklos Z
authors.initials: MZ
authors.lastname: Molnar
authors.affiliation: Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary. Electronic address: mathezol@hotmail.com.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Mathe
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein