title: Ginseng Berry Extract Attenuates Dextran Sodium Sulfate-Induced Acute and Chronic Colitis.
abstract: This study investigates the in vivo functions of ginseng berry extract (GB) as a therapy for dextran sodium sulfate (DSS)-induced colitis. C57BL/6 mice were given drinking water containing DSS (3%) for eight days to induce acute colitis. At the same time, the mice received an oral dose of GB (50 mg/kg) once daily. The GB-treated mice were less susceptible to the development of acute colitis than were control mice treated with saline, as determined by weight loss, disease activity, and colon histology. The administration of GB to DSS-treated mice also reduced the numbers and inhibited the activation of colon-infiltrating T cells, neutrophils, intestinal CD103(-)CD11c⁺ dendritic cells (cDCs), and macrophages. In addition, GB treatment promoted the migration of CD103⁺CD11c⁺ cDCs and expansion of Foxp3⁺ regulatory T cells in the colons of DSS-treated mice. Similarly, in the DSS-induced chronic colitis model, GB treatment improved the macroscopic and histological appearance of the colon wall when compared to untreated control mice, as indicated by longer colon length and lower histological scores. This is the first report to show that oral administration of GB suppresses immune activation and protects against experimentally induced colitis.
authors.affiliation: Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China. weiwei061215@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China. wendengxvli@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: R &amp; D Unit, AmorePacific Corporation, 1920 Yonggudae-ro, Giheung-gu, Yongin-si, Gyeonggi-do 17074, Korea. csy1010@amorepacific.com.
authors.forename: Si-Young
authors.initials: SY
authors.lastname: Cho
authors.affiliation: Department of Biological Sciences, Inha University, Incheon 22212, Korea. minkj@inha.ac.kr.
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Min
authors.affiliation: Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Nagasaki 55001, Japan. t-oda@nagasaki-u.ac.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Oda
authors.affiliation: Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China. zhanglijun1221@163.com.
authors.forename: LiJun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA. Qyu@forsyth.org.|Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA. Qyu@forsyth.org.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China. junojin1@gmail.com.
authors.forename: Jun-O
authors.initials: JO
authors.lastname: Jin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003092:Colitis / Q000139:chemically induced* / Q000517:prevention & control; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D016264:Dextran Sulfate / Q000633:toxicity*; D005638:Fruit / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D007422:Intestines / Q000166:cytology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018417:Th1 Cells; D058504:Th17 Cells
chemical_list: D016207:Cytokines; D010936:Plant Extracts; D016264:Dextran Sulfate
keywords: ginseng berry extract; intestinal dendritic cell; intestinal macrophage; mouse colitis