title: Long-term outcome of pediatric kidney transplantation: A single-center experience from Greece.
abstract: Pediatric kidney Tx has critically altered the outcome in ESRD pediatric patients. The aims of this study were to determine long-term graft and patient survival in a homogeneous ethnic population. We reviewed the medical charts of pediatric kidney Tx performed between 1990 and 2012 in Greece. Seventy-five kidney Txs were performed from LRD and 62 from DD. The 10- and 20-yr graft survival was higher in LRD Tx compared with DD Tx. Both patient and graft survival at 10 and 20 yr after Tx were similar in LRD Tx from grandparents compared with parents (92.9% vs. 93.4% 20-yr patient survival, 71.4% vs. 78.7% and 57.1% vs. 72.1%, 10- and 20-yr graft survival, respectively). However, there was a decreasing tendency in LRD Tx rates in period 2001-2012 compared with period 1990-2000 (47.1% vs. 62.7%). Risk factors for poor five-yr graft survival were DD Tx, and induction treatment with ALG compared with basiliximab, but their effect attenuated at 10 yr after Tx. In conclusion, Tx from LRD may offer efficient survival outcomes irrespective of donor age, suggesting that even older LRD could be an excellent option for the 1st kidney Tx in children and adolescents.
authors.affiliation: Pediatric Nephrology Unit, 1st Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Fotios
authors.initials: F
authors.lastname: Papachristou
authors.affiliation: Pediatric Nephrology Unit, 1st Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Stella
authors.initials: S
authors.lastname: Stabouli
authors.affiliation: Pediatric Nephrology Unit, 1st Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Nikoleta
authors.initials: N
authors.lastname: Printza
authors.affiliation: Department of Nephrology, "P. and A. Kyriakou" Children's Hospital, Athens, Greece.
authors.forename: Andromachi
authors.initials: A
authors.lastname: Mitsioni
authors.affiliation: Department of Nephrology, "P. and A. Kyriakou" Children's Hospital, Athens, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Stefanidis
authors.affiliation: Division of Transplantation, Department of Surgery, Medical School, Aristotle University and Hippokration General Hospital, Thessaloniki, Greece.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Miserlis
authors.affiliation: Pediatric Nephrology Unit, 1st Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Dotis
authors.affiliation: Department of Nephrology, "Agia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kapogiannis
authors.affiliation: Department of Nephrology, "Agia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Helen
authors.initials: H
authors.lastname: Georgaki-Angelaki
authors.affiliation: Pediatric Nephrology Unit, 1st Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Chrysa
authors.initials: C
authors.lastname: Gkogka
authors.affiliation: 3rd Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kollios
authors.affiliation: Division of Transplantation, Department of Surgery, Medical School, Aristotle University and Hippokration General Hospital, Thessaloniki, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Papanikolaou
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006115:Greece; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality* / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
keywords: graft survival; hypertension; living related donor; patient survival; pediatric kidney transplantation