title: Key Considerations in Designing Oral Drug Delivery Systems for Dogs.
abstract: The present review discusses the pharmaceutical impact of the anatomy and physiology of the canine gastrointestinal tract to provide a comprehensive guide to the theories and challenges associated with the development of oral drug delivery systems for dogs. Novel pharmaceutical technologies applied to veterinary drugs are discussed indicating the advantages and benefits for animals. There are currently immense research and development efforts being funneled into novel canine health products. Such products are being used to overcome limitations of drugs that display site-dependent absorption or possess poor biopharmaceutical properties. Techniques that are employed to increase bioavailability of the Biopharmaceutics Classification System class II drugs are discussed in this article. Furthermore, an overview of palatable oral formulations for dog care is provided as an approach to easy administration. In vitro and in vivo evaluation and correlation of oral drug formulations in dogs are also addressed. This article assesses the outlook of canine oral drug development recognizing substantial growth forecasts of the dog care market.
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia.
authors.forename: Yunmei
authors.initials: Y
authors.lastname: Song
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia.
authors.forename: Karl
authors.initials: K
authors.lastname: Peressin
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia.
authors.forename: Pooi Yin
authors.initials: PY
authors.lastname: Wong
authors.affiliation: Luoda Pharma, Caringbah, NSW, Australia.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Page
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia. Electronic address: sanjay.garg@unisa.edu.au.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Garg
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D015195:Drug Design; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D004364:Pharmaceutical Preparations
keywords: ADME; Biopharmaceutics Classification System; gastrointestinal transit; in vitro models; in vitro/in vivo correlations; oral absorption; oral drug delivery