title: Mild protein hydrolysation of lactose-free milk further reduces milk-related gastrointestinal symptoms.
abstract: Gastrointestinal symptoms associated with milk are common. Besides lactose, milk proteins may cause symptoms in sensitive individuals. We have developed a method for mild enzymatic hydrolysation of milk proteins and studied the effects of hydrolysed milk on gastrointestinal symptoms in adults with a self-diagnosed sensitive stomach. In a double blind, randomised placebo-controlled study, 97 subjects consumed protein-hydrolysed lactose-free milk or commercially available lactose-free milk for 10 d. Frequency of gastrointestinal symptoms during the study period was reported and a symptom score was calculated. Rumbling and flatulence decreased significantly in the hydrolysed milk group (P < 0·05). Also, the total symptom score was lower in subjects who consumed hydrolysed milk (P < 0·05). No difference between groups was seen in abdominal pain (P = 0·47) or bloating (P = 0·076). The results suggest that mild enzymatic protein hydrolysation may decrease gastrointestinal symptoms in adults with a sensitive stomach.
authors.affiliation: Valio Ltd,R&D,P.O. Box 30,00039 Valio,Finland.
authors.forename: Anu
authors.initials: A
authors.lastname: Turpeinen
authors.affiliation: Valio Ltd,R&D,P.O. Box 30,00039 Valio,Finland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Kautiainen
authors.affiliation: Valio Ltd,R&D,P.O. Box 30,00039 Valio,Finland.
authors.forename: Marja-Leena
authors.initials: ML
authors.lastname: Tikkanen
authors.affiliation: Valio Ltd,R&D,P.O. Box 30,00039 Valio,Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Sibakov
authors.affiliation: Valio Ltd,R&D,P.O. Box 30,00039 Valio,Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Tossavainen
authors.affiliation: Valio Ltd,R&D,P.O. Box 30,00039 Valio,Finland.
authors.forename: Eveliina
authors.initials: E
authors.lastname: Myllyluoma
mesh_terms: D015746:Abdominal Pain / Q000453:epidemiology; D000328:Adult; D000818:Animals; D004311:Double-Blind Method; D005414:Flatulence / Q000453:epidemiology; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D006868:Hydrolysis; D007785:Lactose / Q000009:adverse effects / Q000032:analysis*; D008875:Middle Aged; D008892:Milk / Q000009:adverse effects* / Q000737:chemistry*; D008894:Milk Proteins / Q000009:adverse effects / Q000378:metabolism*; D010919:Placebos
chemical_list: D008894:Milk Proteins; D010919:Placebos; D007785:Lactose
keywords: Milk protein; enzymatic hydrolysation; gastrointestinal symptoms; human