title: Reproducibility of myocardial T1and T2relaxation time measurement using slice-interleaved T1and T2mapping sequences.
abstract: To assess measurement reproducibility and image quality of myocardial T1and T2maps using free-breathing slice-interleaved T1and T2mapping sequences at 1.5 Tesla (T).
  
  
  
  Eleven healthy subjects (33 ± 16 years; 6 males) underwent a slice-interleaved T1and T2mapping test/retest cardiac MR study at 1.5T on 2 days. For each day, subjects were imaged in two sessions with removal out of the magnet and repositioning before the subsequent session. We studied measurement reproducibility as well as the required sample size for sufficient statistical power to detect a predefined change in T1and T2. In a separate prospective study, we assessed T1and T2map image quality in 241 patients (54 ± 15 years; 73 women) with known/suspected cardiovascular disease referred for clinical cardiac MR. A subjective quality score was used to assess a segment-based image quality.
  
  
  
  In the healthy cohort, the slice-interleaved T1measurements were highly reproducible, with global coefficients of variation (CVs) of 2.4% between subjects, 2.1% between days, and 1.7% between sessions. Slice-interleaved T2mapping sequences provided similar reproducibility with global CVs of 7.2% between subjects, 6.3% between days, and 5.0 between sessions. A lower variability resulted in a reduction of the required number of subjects to achieve a certain statistical power when compared with other T1mapping sequences. In the subjective image quality assessment, >80% of myocardial segments had interpretable data.
  
  
  
  Slice-interleaved T1and T2mapping sequences yield highly reproducible T1and T2measurements with >80% of interpretable myocardial segments. J. Magn. Reson. Imaging 2016;44:1159-1167.
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Bellm
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Tamer A
authors.initials: TA
authors.lastname: Basha
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Ravi V
authors.initials: RV
authors.lastname: Shah
authors.affiliation: Department of Medicine (Cardiovascular Division), University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Venkatesh L
authors.initials: VL
authors.lastname: Murthy
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Charlene
authors.initials: C
authors.lastname: Liew
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Maxine
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Long H
authors.initials: LH
authors.lastname: Ngo
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.|Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Manning
authors.affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. rnezafat@bidmc.harvard.edu.
authors.forename: Reza
authors.initials: R
authors.lastname: Nezafat
mesh_terms: D000328:Adult; D057791:Cardiac Imaging Techniques / Q000379:methods*; D005260:Female; D006321:Heart / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: myocardial tissue characterization and relaxometry; sample size justification; slice-interleaved T1 and T2 mapping sequence