title: The influence of mPEG-PCL and mPEG-PLGA on encapsulation efficiency and drug-loading of SN-38 NPs.
abstract: The influence of mPEG-PCL and mPEG-PLGA on encapsulation efficiency and drug-loading of nanoparticles was very important. SN-38 NPs were prepared from a series of diblock copolymers: mPEG1000-PLGA2000, mPEG2000-PCLs, mPEG5000-PCLs, mPEG2000-PLGAs, and mPEG5000-PLGAs by the thin film-hydration method. The prepared nanoparticles were characterized by morphology, size, encapsulation efficiency, drug-loading, and in vitro release behavior. This experiment suggested that the encapsulation efficiency and drug-loading of SN-38 NPs were attained the maximum values when the ratio of hydrophilic to hydrophobic block was between 1:2 and 1:3.
authors.affiliation: a School of Pharmacy, Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Mengyue
authors.initials: M
authors.lastname: Gan
authors.affiliation: b Department of Pharmacy , Institute of Clinical Pharmacology, General Hospital of Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Zhang
authors.affiliation: b Department of Pharmacy , Institute of Clinical Pharmacology, General Hospital of Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Wei
authors.affiliation: b Department of Pharmacy , Institute of Clinical Pharmacology, General Hospital of Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Hongwan
authors.initials: H
authors.lastname: Dang
mesh_terms: D002166:Camptothecin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000077146:Irinotecan; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D011091:Polyesters; C558447:methoxypolyethyleneglycol-poly(lactic-co-glycolic acid); D011092:Polyethylene Glycols; D000077146:Irinotecan; D002166:Camptothecin
keywords: Diblock copolymer; HPLC; SN-38; TEM; drug-loading; encapsulation efficiency; mPEG-PCL; mPEG-PLGA; nanoparticles