title: Is Retinal Nerve Fiber Layer Thickness Change Related to Headache Lateralization in Migraine?
abstract: OBJECTIVE
  To evaluate retinal nerve fiber layer (RNFL) thickness in migraine patients with unilateral headache.
  
  
  METHODS
  A total of 58 patients diagnosed with migraine headache consistently occurring on the same side and 58 age- and sex-matched healthy subjects were evaluated in this cross-sectional study. RNFL thickness was measured using spectral-domain optical coherence tomography, and the side with the headache was compared with the contralateral side as well as with the results of healthy subjects.
  
  
  RESULTS
  The mean patient age was 33.05 ± 8.83 years, and that of the healthy subjects was 31.44 ± 8.64 years (p = 0.32). The mean duration of disease was 10.29 ± 9.03 years. The average and nasal RNFL thicknesses were significantly thinner on the side of headache and on the contralateral side compared to control eyes (p < 0.05, for all). Thinning was higher on the side of the headache compared to the contralateral side; however, this difference was not statistically significant.
  
  
  CONCLUSIONS
  The RNFL thicknesses were thinner on the side of the headache compared to the contralateral side in the migraine patients with unilateral headache, but this difference was not statistically significant.
authors.affiliation: Department of Ophthalmology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Alime
authors.initials: A
authors.lastname: Gunes
authors.affiliation: Department of Neurology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Seden
authors.initials: S
authors.lastname: Demirci
authors.affiliation: Department of Ophthalmology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Tok
authors.affiliation: Department of Ophthalmology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Tok
authors.affiliation: Department of Neurology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Demirci
authors.affiliation: Department of Neurology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Kutluhan
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D055815:Young Adult
keywords: Migraine; Retinal nerve fiber layer thickness; Unilateral headache