title: [Tension type headache: GABA-ergic drug anvifen efficacy].
abstract: OBJECTIVE
  To assess the efficacy of aminophenylbutyric acid (anvifen), a synthetic GABA-receptor agonist, in the treatment of adult patients with tension type headache (TTH).
  
  
  METHODS
  Eighty-seven patients with episodic TTH (ETTH) and 30 patients with chronic TTH (CTTH) were examined. The area under the headache curve, sleep quality, the Hospital Anxiety and Depression Scale (HADS) scores and stress resistance measured by an original questionnaire were evaluated.
  
  
  RESULTS
  Anvifen in dose of 250 mg TID during 3 weeks had a positive effect on all parameters studied, excluding the area under the headache curve in CTTH. Similar results were demonstrated after the subsequent course of treatment for 3 weeks.
  
  
  CONCLUSIONS
  Anvifen was highly effective in ETTH but less effective in CTTH. A combination of anvifen with antidepressants can be recommended for patients with CTTH.
authors.affiliation: Kazan Federal University, Kazan.
authors.forename: O R
authors.initials: OR
authors.lastname: Esin
authors.affiliation: Kazan Federal University, Kazan.
authors.forename: I Kh
authors.initials: IK
authors.lastname: Khairullin
authors.affiliation: Kazan Federal University, Kazan; Kazan State Medical Academy, Kazan.
authors.forename: R G
authors.initials: RG
authors.lastname: Esin
authors.affiliation: Kazan Federal University, Kazan.
authors.forename: N V
authors.initials: NV
authors.lastname: Tokareva
mesh_terms: D000328:Adult; D005260:Female; D018755:GABA Agonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018781:Tension-Type Headache / Q000188:drug therapy*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D018755:GABA Agonists; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid