title: LINC00507 Is Specifically Expressed in the Primate Cortex and Has Age-Dependent Expression Patterns.
abstract: Over the past decade, there has been an increase in the appreciation of the role of non-coding RNA in the development of organism phenotype. It is possible to divide the non-coding elements of the transcriptome into three categories: short non-coding RNAs, circular RNAs and long non-coding RNAs. Long non-coding RNAs are those transcripts that are greater than 200 nts in length and lack any significant open reading frames that produce proteins greater then 100 amino acids. Long intervening non-coding RNAs (lincRNAs) are a subclass of long non-coding RNAs. In contrast to protein coding RNAs, lincRNAs are expressed in a more tissue- and species-specific manner. In particular, many lincRNAs are only conserved amongst higher primates. This coupled with the propensity of many lincRNAs to be expressed in the brain, suggests that they are in fact one of the major drivers of organism complexity. We analysed 39 lincRNAs that are expressed in the frontal cortex and identified LINC00507 as being expressed in a cortex-specific manner in non-human primates and humans. The expression patterns of LINC00507 appear to be age-dependent, suggesting it may be involved in brain development of higher primates. Moreover, the analysis of LINC00507 potential to bind ribosomes revealed that this previously identified non-coding transcript may harbour a micropeptide.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Sydney, 2052, Australia.|Department of (Neuro) Pathology, Academic Medical Center and Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: James D
authors.initials: JD
authors.lastname: Mills
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Sydney, 2052, Australia.
authors.forename: Melanie
authors.initials: M
authors.lastname: Ward
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Sydney, 2052, Australia.
authors.forename: Bei Jun
authors.initials: BJ
authors.lastname: Chen
authors.affiliation: Department of (Neuro) Pathology, Academic Medical Center and Swammerdam Institute for Life Sciences, Center for Neuorscience, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Anand M
authors.initials: AM
authors.lastname: Iyer
authors.affiliation: Department of (Neuro) Pathology, Academic Medical Center and Swammerdam Institute for Life Sciences, Center for Neuorscience, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Aronica
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Sydney, 2052, Australia. m.janitz@unsw.edu.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Janitz
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D017124:Conserved Sequence; D018507:Gene Expression Regulation, Developmental; D009928:Organ Specificity; D011323:Primates / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: Brain; Cerebral cortex; LINC00507; Micropeptide; Non-coding RNA; RNA-Seq; lincRNAs