title: Two-dimensional MoS2: A promising building block for biosensors.
abstract: Recently, two-dimensional (2D) layered nanomaterials have trigged intensive interest due to the intriguing physicochemical properties that stem from a quantum size effect connected with their ultra-thin structure. In particular, 2D molybdenum disulfide (MoS2), as an emerging class of stable inorganic graphene analogs with intrinsic finite bandgap, would possibly complement or even surpass graphene in electronics and optoelectronics fields. In this review, we first discuss the historical development of ultrathin 2D nanomaterials. Then, we are concerned with 2D MoS2including its structure-property relationships, synthesis methods, characterization for the layer thickness, and biosensor applications over the past five years. Thereinto, we are highlighting recent advances in 2D MoS2-based biosensors, especially emphasize the preparation of sensing elements, roles of 2D MoS2, and assay strategies. Finally, on the basis of the current achievements on 2D MoS2and other ultrathin layered nanomaterials, perspectives on the challenges and opportunities for the exploration of 2D MoS2-based biosensors are put forward.
authors.affiliation: Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, China), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Gan
authors.affiliation: Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, China), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China. Electronic address: zhaohuim@dlut.edu.cn.
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, China), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
authors.forename: Xie
authors.initials: X
authors.lastname: Quan
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004220:Disulfides / Q000737:chemistry*; D004867:Equipment Design; D006801:Humans; D008958:Models, Molecular; D008982:Molybdenum / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*
chemical_list: D004220:Disulfides; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: Biosensors; MoS(2); Two-dimensional nanomaterials