title: Effect of gingival inflammation on the inflammatory response in patients with idiopathic uveitis.
abstract: This study aimed to investigate the levels of 11 oral species in plaque samples and cytokine levels in biofluid samples of patients with idiopathic uveitis (IU) and systemically healthy individuals (H) with or without gingival inflammation.
  
  
  
  Twenty-one patients with IU (n = 21), and 22 systemically healthy individuals (n = 22) were enrolled in the study. Clinical periodontal measurements were recorded. Cytokine levels in the biofluid samples were determined by ELISA. Bacterial gene copy numbers were determined by qPCR on plaque microbial DNA preparations.
  
  
  
  According to two-step cluster analysis, anova and t-test: GCF, serum and salivary TNF-α, IL-17A, IL-17A/E; GCF and serum IL-6; salivary IL-17F, and salivary and serum IL-17A/F levels were higher in the IU group than the H group (p < 0.05). However, serum IL-10 and IL-17E levels were higher in the H group than the IU group (p < 0.05). A. actinomycetemcomitans, F. nucleatum, S. oralis, A. naeslundii, and V. dispar counts were higher in IU group compared to H group (p < 0.05).
  
  
  
  Altered local and systemic cytokine profiles are associated with differences in the microbial plaque composition in IU. Anti-inflammatory cytokines; IL-10, IL-17E are reduced in patients with IU and Th-1 and Th-17 driven inflammatory responses in biofluids are altered.
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors.forename: Aliye
authors.initials: A
authors.lastname: Akcalı
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Suzan
authors.initials: S
authors.lastname: Güven Yılmaz
authors.affiliation: Infection and Immunity Group, Dental Hospital and School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: David F
authors.initials: DF
authors.lastname: Lappin
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Eğrilmez
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors.forename: Nurcan
authors.initials: N
authors.lastname: Buduneli
mesh_terms: D005883:Gingival Crevicular Fluid; D005891:Gingivitis; D006801:Humans; D007249:Inflammation; D020381:Interleukin-17; D014605:Uveitis
chemical_list: D020381:Interleukin-17
keywords: cytokine(s); dental plaque; gingivitis; interleukin(s); uveitis