title: Prostaglandin-targeting agents and spectral heart rate variability in experimental partial bladder outlet obstruction in rats.
abstract: The purpose of this study was to determine the activity of the autonomic nervous system (ANS), using spectral analysis of the heart rate variability (HRV) in the model of partial bladder outlet obstruction (PBOO) in rats treated with selected non-steroidal anti-inflammatory drugs (NSAID): piroxicam (PRX) or meloxicam (MLX), and following administration of PGF2a prostaglandin analogue (Enzaprost F5). Neither the use of PGF2a analogue nor of MLX, caused significant changes in the HRV spectrum (except for HRV spectrum total power reduction with MLX). The use of PRX caused reduction of the total power and powers of all components of the HRV spectrum (except for VLF). Moreover, increased nLF and reduced nHF were observed. The obtained results suggest that the total prostaglandin synthesis block with a non-selective cyclooxygenase inhibitor (PRX) results in reduced ANS total activity, with decreased parasympathetic activity and a relative sympathetic predominance. The preferential cyclooxygenase-2 block (MLX) caused reduction of the total ANS activity as well, however with no clear disproportion of any part of the ANS. Therefore, prostaglandin synthesis inhibition and associated decrease of parasympathetic activity may constitute an additional and favourable feature of NSAID pharmacodynamics in the treatment of BPH.
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College , Cracow , Poland.
authors.forename: Ł
authors.initials: Ł
authors.lastname: Dobrek
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College , Cracow , Poland.
authors.forename: A
authors.initials: A
authors.lastname: Baranowska
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College , Cracow , Poland.
authors.forename: B
authors.initials: B
authors.lastname: Skowron
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College , Cracow , Poland.
authors.forename: A
authors.initials: A
authors.lastname: Furgała
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College , Cracow , Poland.
authors.forename: D
authors.initials: D
authors.lastname: Żurowski
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College , Cracow , Poland.
authors.forename: P
authors.initials: P
authors.lastname: Thor
mesh_terms: D000818:Animals; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D015237:Dinoprost / Q000494:pharmacology; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects*; D000077239:Meloxicam; D058990:Molecular Targeted Therapy / Q000379:methods*; D010894:Piroxicam / Q000494:pharmacology / Q000627:therapeutic use; D011448:Prostaglandin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D011453:Prostaglandins / Q000378:metabolism; D011465:Prostaglandins, Synthetic / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013843:Thiazines / Q000494:pharmacology / Q000627:therapeutic use; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D013843:Thiazines; D013844:Thiazoles; D010894:Piroxicam; D015237:Dinoprost; D000077239:Meloxicam
keywords: autonomic nervous system; bladder; heart rate variability; meloxicam; piroxicam; prostaglandins