title: Predicting the Efficacy of Protein-Energy Supplementation in Frail Older Adults Living in Community.
abstract: BACKGROUND
  Protein-energy malnutrition is a major cause of functional decline in the elderly and is clearly an important component of frailty. However, limited evidence is available about how to select frail individuals most benefiting from protein-energy supplementation.
  
  
  OBJECTIVE
  1) To investigate factors associated with stronger benefits from protein-energy supplementation, and 2) to test the hypothesis that the severity of frailty is associated with the efficacy of protein-energy supplementation.
  
  
  METHODS
  Secondary analysis of data from a pre-post-intervention study and a clinical trial.
  
  
  METHODS
  National Home Healthcare Services in Gangbuk-gu, Seoul, South Korea.
  
  
  METHODS
  123 community-dwelling frail older adults [usual gait speed (UGS) <0.6m/sec and Mini Nutritional Assessment (MNA) <24].
  
  
  METHODS
  Each participant was received with two 200 mL per day of commercial liquid formula (providing additional 400 kcal of energy and 25 g of protein per day) for 12 weeks.
  
  
  METHODS
  Relative change in the Physical Functioning (PF) and Short Physical Performance Battery (SPPB) score between the baseline and 12-week follow-up assessments were measured.
  
  
  RESULTS
  Multilevel mixed-effect linear regression analysis showed that a lower level of baseline UGS was associated with a greater improvement in PF and SPPB score after adjustment for age, gender, education, living status, beneficiary of public assistance, number of chronic diseases, compliance, and type of dataset (p<0.001). A lower level of baseline MNA score was associated with greater change in PF and SPPB score after adjustment for multiple covariates (p≤0.045). Participants with severe frailty (UGS <0.3 m/sec + MNA <17) showed 52.4% and 44.6% more relevant improvements in PF and SPPB score, respectively, than those with mild frailty (UGS 0.3-0.6 m/sec + MNA 17-24) (p<0.001).
  
  
  CONCLUSIONS
  Slower UGS and lower MNA score are independently associated with the greater efficacy of protein-energy supplementation on functional status.
authors.affiliation: Chang-O Kim, Medical and Health Policy Division, Seoul Metropolitan Government, 110, Sejong-daero, Jung-gu, Seoul, Republic of Korea. Phone: (+82) 2 2133 7524. Fax: (+82) 2 2133 0724. E-mail: nationi@korea.kr.
authors.forename: C O
authors.initials: CO
authors.lastname: Kim