title: Cancer and Chemokines.
abstract: Chemokines are a large family of secreted cytokines whose main function is to mediate leukocyte directional migration. Most cancers contain chemokines and express chemokine receptors as a consequence of the activity of deregulated transcription factors or tumor-suppressor genes. Indeed chemokines expression at the tumor site dictates leukocyte infiltration and angiogenesis, while chemokine receptors expression by tumor cells promotes their growth and matastatization. Chemokines also have several indirect effects on tumor growth and are a relevant element in the cancer-related inflammation. In this chapter we will describe technical approaches available to study the role of chemokines in leukocyte infiltration and tumor metastatization in murine tumor models.
authors.affiliation: Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, I-20089, Milano, Italy.|Department of Medical Biotechnologies and Translational Medicine, University of Milano, School of Medicine, Rozzano, Milano, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Caronni
authors.affiliation: Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, I-20089, Milano, Italy. benedetta.savino@humanitasresearch.it.|Department of Medical Biotechnologies and Translational Medicine, University of Milano, School of Medicine, Rozzano, Milano, Italy. benedetta.savino@humanitasresearch.it.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Savino
authors.affiliation: Mouse and Animal Pathology Laboratory, Fondazione Filarete, Milano, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Recordati
authors.affiliation: Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milano, Milano, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Villa
authors.affiliation: Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, I-20089, Milano, Italy.|Department of Medical Biotechnologies and Translational Medicine, University of Milano, School of Medicine, Rozzano, Milano, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
authors.affiliation: Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, I-20089, Milano, Italy.|Humanitas University, Rozzano, Milano, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000556:secondary; D000818:Animals; D045744:Cell Line, Tumor; D018925:Chemokines / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000556:secondary; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation
chemical_list: D018925:Chemokines
keywords: Cancer-related inflammation; Chemokines; Metastasis; Tumor-infiltrating leukocytes