title: [Cognitive Impairment in Multiple Sclerosis].
abstract: While cognitive impairment is a major symptom of multiple sclerosis (MS), it is commonly overlooked. This may be explained by the fact that it is difficult to evaluate cognitive function in patients with MS using screening batteries for the detection of dementia such as the mini-mental state examination. Further more, cognitive impairment in MS typically involves domain-specific deficits such as imparement of sustained attention and information processing speed rather than global cognitive decline. Cognitive impairment may influence the daily living and social lines of affected patients. This review discusses the characteristics of cognitive impairment, appropreate tests to evaluate its symptoms, and the current status of clinical trials for the treatment of MS.
authors.affiliation: Departments of Clinical Research, Hokkaido Medical Center.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Niino
authors.forename: Yusei
authors.initials: Y
authors.lastname: Miyazaki
mesh_terms: D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003704:Dementia / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D009483:Neuropsychological Tests