title: Effect of morroniside on glomerular mesangial cells through AGE-RAGE pathway.
abstract: Diabetes mellitus is an endocrine and metabolic disease characterized by high blood glucose. Diabetic nephropathy (DN) is one of the most typical diabetic complications. Cornus officinalis is a type of traditional Chinese medicine that replenishes the liver and kidney. Morroniside is one of the main characteristic components of C. officinalis. In this study, an in vitro model for simulating DN damage was established by stimulating rat glomerular mesangial cells by the advanced glycation end products. The protective mechanism and effect of morroniside in regulating receptor for advanced glycation end products signaling pathway in DN was investigated to provide experimental evidence for the prevention and treatment of DN.
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Gaohong
authors.initials: G
authors.lastname: Lv
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Lv
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Yuhan
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. huiqin_xu@yahoo.com.|Jiang Su Key Laboratory for Efficacy and Safety Evaluation of Chinese Medicine, Nanjing, 210023, Jiangsu, China. huiqin_xu@yahoo.com.
authors.forename: Huiqin
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D029768:Cornus / Q000737:chemistry; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000235:genetics / Q000517:prevention & control; D015536:Down-Regulation / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects*; D017127:Glycation End Products, Advanced / Q000009:adverse effects*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D050527:Mesangial Cells / Q000187:drug effects* / Q000473:pathology*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008517:Phytotherapy; D051381:Rats; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: C000593874:Ager protein, rat; D017127:Glycation End Products, Advanced; D006027:Glycosides; D016328:NF-kappa B; D000067759:Receptor for Advanced Glycation End Products; D016212:Transforming Growth Factor beta; C488401:morroniside; D048051:p38 Mitogen-Activated Protein Kinases
keywords: AGE–RAGE pathway; Diabetic nephropathy; Glomerular mesangial cells; Morroniside