title: Population variation of HLA genes in rural communities in Brazil, the Quilombos from the Vale do Ribeira, São Paulo - Brazil.
abstract: In the present study, we characterized the allelic and haplotypic profile of the genes HLA-A, -B, -C and -DRB1 (PCR-SBT) in a population sample of 144 highly admixed individuals, coming from rural communities in Brazil (Quilombos from Vale do Ribeira, in the State of São Paulo). Furthermore, we identified three individuals with a new null allele in the HLA-C gene (HLA-C(∗)02:105N), associated with the haplotype HLA-A(∗)80: 01∼B(∗)18: 01:01G∼DRB1(∗) 07:01.
authors.affiliation: University of São Paulo, Department of Genetics and Evolutionary Biology, São Paulo, Brazil.
authors.forename: Kelly
authors.initials: K
authors.lastname: Nunes
authors.affiliation: JRM-Investigações Imunológicas, Rio de Janeiro, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Piovezan
authors.affiliation: JRM-Investigações Imunológicas, Rio de Janeiro, Brazil.
authors.forename: Margareth A
authors.initials: MA
authors.lastname: Torres
authors.affiliation: JRM-Investigações Imunológicas, Rio de Janeiro, Brazil.
authors.forename: Gerlândia N
authors.initials: GN
authors.lastname: Pontes
authors.affiliation: University of São Paulo, Department of Genetics and Evolutionary Biology, São Paulo, Brazil.
authors.forename: Lilian
authors.initials: L
authors.lastname: Kimura
authors.affiliation: University of São Paulo, Department of Genetics and Evolutionary Biology, São Paulo, Brazil.
authors.forename: Juliana E P
authors.initials: JE
authors.lastname: Carnavalli
authors.affiliation: University of São Paulo, Department of Genetics and Evolutionary Biology, São Paulo, Brazil.
authors.forename: Regina Célia
authors.initials: RC
authors.lastname: Mingroni Netto
authors.affiliation: JRM-Investigações Imunológicas, Rio de Janeiro, Brazil.
authors.forename: Maria Elisa
authors.initials: ME
authors.lastname: Moraes
authors.affiliation: University of São Paulo, Department of Genetics and Evolutionary Biology, São Paulo, Brazil. Electronic address: diogo@ib.usp.br.
authors.forename: Diogo
authors.initials: D
authors.lastname: Meyer
mesh_terms: D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012424:Rural Population
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D059811:HLA-DRB1 Chains
keywords: Brazilian population; HLA; HLA haplotypes; New allele