title: Sialic Acid Mimetics to Target the Sialic Acid-Siglec Axis.
abstract: Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on immune cells. Aberrant sialic acid-Siglec interactions are associated with an increasing number of pathologies including infection, autoimmunity, and cancer. Therefore, the sialic acid-Siglec axis is an emerging target to prevent or affect the course of several diseases. Chemical modifications of the natural sialic acid ligands have led to sialic acid mimetics (SAMs) with improved binding affinity and selectivity towards Siglecs. Recent progress in glycobiotechnology allows the presentation of these SAMs on nanoparticles, polymers, and living cells via bioorthogonal synthesis. These developments now enable the detailed study of the sialic acid-Siglec axis including its therapeutic potential as an immune modulator.
authors.affiliation: Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 Nijmegen GA, The Netherlands.
authors.forename: Christian
authors.initials: C
authors.lastname: Büll
authors.affiliation: Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 Nijmegen AJ, The Netherlands.
authors.forename: Torben
authors.initials: T
authors.lastname: Heise
authors.affiliation: Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 Nijmegen GA, The Netherlands. Electronic address: Gosse.Adema@radboudumc.nl.
authors.forename: Gosse J
authors.initials: GJ
authors.lastname: Adema
authors.affiliation: Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 Nijmegen AJ, The Netherlands. Electronic address: T.Boltje@science.ru.nl.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Boltje
mesh_terms: D000375:Aging / Q000276:immunology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D040761:Biomimetic Materials / Q000737:chemistry / Q000627:therapeutic use*; D002240:Carbohydrate Sequence; D004337:Drug Carriers; D015870:Gene Expression; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D007155:Immunologic Factors / Q000737:chemistry / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D058990:Molecular Targeted Therapy; D022423:Myeloid Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D053758:Nanoparticles / Q000627:therapeutic use; D011485:Protein Binding; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D012794:Sialic Acids / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000276:immunology*; D012799:Sialyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology
chemical_list: D004337:Drug Carriers; D007155:Immunologic Factors; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D012794:Sialic Acids; D012799:Sialyltransferases
keywords: Siglecs; glycans; glycoengineering; sialic acid mimetics; sialic acids; sialome