title: Genotypically determined ancestry across an infertile population: ovarian reserve and response parameters are not influenced by continental origin.
abstract: OBJECTIVE
  To evaluate the relationship between genetic ethnicity using ancestry informative markers (AIMs) and ovarian reserve and response parameters as evidenced by FSH, antimüllerian hormone (AMH), basal antral follicle count (BAFC), and total oocyte yield in IVF.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  A total of 2,508 infertile patients undergoing IVF at a single center.
  
  
  METHODS
  Patients were genotyped for 32 AIMs and analyzed for differences in allele frequencies. A validated Bayesian clustering algorithm was then used to assign individuals into one of four ethnic populations: European, African, Central/South Asian, or East Asian.
  
  
  METHODS
  FSH, AMH, BAFC, and oocyte yield variation.
  
  
  RESULTS
  After controlling for age and body mass index, genetic ethnicity had no impact on AMH, BAFC, and oocyte yield. FSH was found to be lower in patients of Central/South Asian ancestry (6.46 ng/mL vs. 6.97 ng/mL); however, the absolute difference is of little clinical significance. Subgroup analyses of 1,327 patients restricted to those with limited genetic admixture as determined by AIMs indicated that FSH, AMH, BAFC, and oocyte yield were equivalent.
  
  
  CONCLUSIONS
  When determining ethnicity using AIMs, ethnic background does not have an impact on markers of ovarian reserve or ovarian response. Specifically, no differences were found in AMH, BAFC, or oocyte yield relative to genotypic ethnicity. Using AIMs rather than self-reported ethnicity allows for elimination of reporting biases and nonreporting of ethnicity, which can confound data. Based upon these data, specific recommendations for ovarian reserve testing should thus be made based on other factors besides ethnic background.
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology, and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey. Electronic address: olchame@gmail.com.
authors.forename: Meir
authors.initials: M
authors.lastname: Olcha
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology, and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Franasiak
authors.affiliation: Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Shefali
authors.initials: S
authors.lastname: Shastri
authors.affiliation: Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Molinaro
authors.affiliation: Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Haley
authors.initials: H
authors.lastname: Congdon
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology, and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Treff
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology, and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Scott
mesh_terms: D000046:Academic Medical Centers; D054304:Anti-Mullerian Hormone / Q000097:blood; D001499:Bayes Theorem; D015415:Biomarkers; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics* / Q000503:physiopathology; D016014:Linear Models; D009515:New Jersey / Q000453:epidemiology; D054315:Oocyte Retrieval; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D065851:Ovarian Reserve / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D044469:Racial Groups / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D005819:Genetic Markers; D054304:Anti-Mullerian Hormone
keywords: Ovarian reserve; ancestry informative markers; ethnicity