title: Coagulation disorders and their cutaneous presentations: Pathophysiology.
abstract: Hypercoagulable states are inherited or acquired predispositions to venous or arterial thromboses that are best understood in the context of the coagulation cascade. Dermatologists can play a critical role in diagnosing and treating patients with hypercoagulable states because cutaneous symptoms may be a presenting manifestation, thereby reducing morbidity and mortality related to these conditions. This review focuses on the epidemiology and pathophysiology of hypercoagulable states, while the accompanying article iterates the basic clinical features, diagnostic testing, and management of patients who have these conditions.
authors.affiliation: Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Yunyoung
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Dermatology and Skin Surgery, Roger Williams Medical Center/Boston University School of Medicine, Providence, Rhode Island.
authors.forename: Ganary
authors.initials: G
authors.lastname: Dabiri
authors.affiliation: Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Damstetter
authors.affiliation: Department of Hematology and Oncology, University Medical Group, Providence, Rhode Island.
authors.forename: Emily
authors.initials: E
authors.lastname: Baiyee Ebot
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Jennifer Gloeckner
authors.initials: JG
authors.lastname: Powers
authors.affiliation: Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address: tphill@bu.edu.
authors.forename: Tania
authors.initials: T
authors.lastname: Phillips
mesh_terms: D000755:Anemia, Sickle Cell / Q000175:diagnosis* / Q000503:physiopathology; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004502:Education, Medical, Continuing; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D017445:Skin Diseases, Vascular / Q000175:diagnosis* / Q000503:physiopathology; D019851:Thrombophilia / Q000175:diagnosis* / Q000503:physiopathology; D013927:Thrombosis / Q000175:diagnosis / Q000503:physiopathology
keywords: antiphospholipid syndrome; antithrombin; coagulation cascade; cryoglobulinemia; factor V Leiden; hypercoagulable state; hyperhomocysteinemia; protein C; protein S; prothrombin; sickle cell disease