title: Antibody-Mediated Insulin Resistance: When Insulin and Insulin Receptor Act as Autoantigens in Humans.
abstract: We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies and review the therapeutic possibilities.
authors.affiliation: Department of Endocrinology, Diabetology and Nutrition, Groupement Hospitalier Lyon Sud, Fédération Hospitalo-Universitaire DO-IT, Hospices Civils de Lyon, Lyon, France; University Claude Bernard Lyon 1, Lyon, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Liminet
authors.affiliation: Department of Endocrinology, Diabetology and Nutrition, Groupement Hospitalier Lyon Sud, Fédération Hospitalo-Universitaire DO-IT, Hospices Civils de Lyon, Lyon, France. Electronic address: julien.vouillarmet@chu-lyon.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Vouillarmet
authors.affiliation: University Claude Bernard Lyon 1, Lyon, France; Department of Biochemistry, Groupement Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Chikh
authors.affiliation: Department of Endocrinology, Diabetology and Nutrition, Groupement Hospitalier Lyon Sud, Fédération Hospitalo-Universitaire DO-IT, Hospices Civils de Lyon, Lyon, France; University Claude Bernard Lyon 1, Lyon, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Disse
mesh_terms: D000369:Aged, 80 and over; D001324:Autoantigens / Q000378:metabolism*; D015551:Autoimmunity; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D008297:Male
chemical_list: D001324:Autoantigens; D001786:Blood Glucose
keywords: auto-anticorps; auto-immunité; autoantibodies; autoimmunity; insulin; insuline; insulinorésistance grave; severe insulin resistance