title: A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery.
abstract: Herein we report on a charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery. The nanocarrier achieves acid-dependent charge conversion, thus prolonging the circulation time and enhancing antibiotic accumulation in subcutaneous inflammation models.
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, P. R. China. yangcuihong1983@163.com lewis78@163.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Chu
authors.forename: Honglin
authors.initials: H
authors.lastname: Gao
authors.forename: Tangjian
authors.initials: T
authors.lastname: Cheng
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jinjian
authors.initials: J
authors.lastname: Liu
authors.forename: Fan
authors.initials: F
authors.lastname: Huang
authors.forename: Cuihong
authors.initials: C
authors.lastname: Yang
authors.forename: Linqi
authors.initials: L
authors.lastname: Shi
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D011108:Polymers; D014640:Vancomycin