title: Hypothalamic hamartoma with neurofibrillary tangles.
abstract: Hypothalamic hamartomas are rare tumors that typically present in childhood, often with gelastic seizures, precocious puberty, or as a manifestation of Pallister-Hall syndrome. Neurofibrillary tangles are cytoplasmic aggregates of hyperphosphorylated tau that are best recognized in Alzheimer disease, other tau-associated neurodegenerative diseases, or as part of aging, but occasionally may be seen in low-grade neoplasms with a ganglion cell component as gangliocytoma or ganglioglioma. Herein, we report a case of hypothalamic hamartoma with neurofibrillary tangles.
authors.affiliation: Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Wood
authors.affiliation: Michigan State University College of Human Medicine, Flint, Michigan, USA.
authors.forename: Jawad A
authors.initials: JA
authors.lastname: Shah
authors.affiliation: Michigan State University College of Human Medicine, Flint, Michigan, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Vida
authors.affiliation: Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Parisi
authors.affiliation: Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Jentoft
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D006222:Hamartoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins
keywords: gangliocytoma; ganglioglioma; hypothalamic hamartoma; neurofibrillary tangle; tau