title: Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies.
abstract: In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfalls of different types of meta-analyses are reviewed here. Each meta-analysis approach has a place when pivotal clinical trials are lacking and sheds light on the magnitude of the treatment in a complex healthcare field.
authors.affiliation: From the Department of Cardiology, Medical University of Vienna, Vienna, Austria (M.G.); 3rd Department of Cardiology, Medical University of Silesia, Katowice, Poland (W.W.); Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Heinrich-Heine-University, Düsseldorf, Germany (E.P.N.); Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network (E.P.N.); and CCTRN Data Coordinating Center, University of Texas Houston School of Public Health, Houston (L.À.M.). mariann.gyongyosi@meduniwien.ac.at.
authors.forename: Mariann
authors.initials: M
authors.lastname: Gyöngyösi
authors.affiliation: From the Department of Cardiology, Medical University of Vienna, Vienna, Austria (M.G.); 3rd Department of Cardiology, Medical University of Silesia, Katowice, Poland (W.W.); Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Heinrich-Heine-University, Düsseldorf, Germany (E.P.N.); Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network (E.P.N.); and CCTRN Data Coordinating Center, University of Texas Houston School of Public Health, Houston (L.À.M.).
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wojakowski
authors.affiliation: From the Department of Cardiology, Medical University of Vienna, Vienna, Austria (M.G.); 3rd Department of Cardiology, Medical University of Silesia, Katowice, Poland (W.W.); Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Heinrich-Heine-University, Düsseldorf, Germany (E.P.N.); Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network (E.P.N.); and CCTRN Data Coordinating Center, University of Texas Houston School of Public Health, Houston (L.À.M.).
authors.forename: Eliano P
authors.initials: EP
authors.lastname: Navarese
authors.affiliation: From the Department of Cardiology, Medical University of Vienna, Vienna, Austria (M.G.); 3rd Department of Cardiology, Medical University of Silesia, Katowice, Poland (W.W.); Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Heinrich-Heine-University, Düsseldorf, Germany (E.P.N.); Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network (E.P.N.); and CCTRN Data Coordinating Center, University of Texas Houston School of Public Health, Houston (L.À.M.).
authors.forename: Lemuel À
authors.initials: LÀ
authors.lastname: Moye
mesh_terms: D064987:Cell- and Tissue-Based Therapy / Q000379:methods* / Q000401:mortality / Q000639:trends; D006801:Humans; D009026:Mortality / Q000639:trends; D017202:Myocardial Ischemia / Q000401:mortality / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods / Q000401:mortality / Q000639:trends; D016277:Ventricular Function, Left / Q000502:physiology
keywords: heart failure; meta-analysis; myocardial infarction; outcome measures; stem cells