title: Improving lipids with prescription icosapent ethyl after previous use of fish oil dietary supplements.
abstract: Managing dyslipidemia can be challenging in patients with statin intolerance. We describe the lipid effects of icosapent ethyl 4 g/day (high-purity prescription omega-3 eicosapentaenoic acid) in two coronary artery disease patients with statin intolerance who were self-treating with fish oil dietary supplements. After initiating icosapent ethyl, improvements were noted in the first and second patients, respectively, in total cholesterol (-12%; -21%), LDL cholesterol (-3%; -24%), triglycerides (-34%; -16%), non-HDL cholesterol (-12%; -22%), the omega-3 index (+42%; +8%) and eicosapentaenoic acid levels (+275%; +138%). Icosapent ethyl was well tolerated with no adverse events reported. These cases demonstrated favorable lipid effects with prescription icosapent ethyl treatment that may help optimize the care of high-risk coronary artery disease patients with statin intolerance.
authors.affiliation: Reddy Cardiac Wellness, 3519 Town Center Blvd South, Suite A, Sugar Land, TX 77479, USA.
authors.forename: Kota J
authors.initials: KJ
authors.lastname: Reddy
authors.affiliation: Amarin Pharma Inc., 1430 Route 206 N., Bedminster, NJ 07921, USA.
authors.forename: Sumita
authors.initials: S
authors.lastname: Chowdhury
mesh_terms: D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D019587:Dietary Supplements; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D014280:Triglycerides; C035276:eicosapentaenoic acid ethyl ester; D002784:Cholesterol; D015118:Eicosapentaenoic Acid
keywords: Vascepa®; atherosclerosis; dietary supplements; dyslipidemia; eicosapentaenoic acid; fish oil; icosapent ethyl; statin