title: Neurobiology of knowledge and misperception of lyrics.
abstract: We conducted two functional magnetic resonance imaging (fMRI) experiments to investigate the neural underpinnings of knowledge and misperception of lyrics. In fMRI experiment 1, a linear relationship between familiarity with lyrics and activation was found in left-hemispheric speech-related as well as bilateral striatal areas which is in line with previous research on generation of lyrics. In fMRI experiment 2, we employed so called Mondegreens and Soramimi to induce misperceptions of lyrics revealing a bilateral network including middle temporal and inferior frontal areas as well as anterior cingulate cortex (ACC) and mediodorsal thalamus. ACC activation also correlated with the extent to which misperceptions were judged as amusing corroborating previous neuroimaging results on the role of this area in mediating the pleasant experience of chills during music perception. Finally, we examined the areas engaged during misperception of lyrics using diffusion-weighted imaging (DWI) to determine their structural connectivity. These combined fMRI/DWI results could serve as a neurobiological model for future studies on other types of misunderstanding which are events with potentially strong impact on our social life.
authors.affiliation: Department of Biomedical Magnetic Resonance, University of Tübingen, Otfried-Müller-Str. 51, 72076 Tübingen, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Beck Lidén
authors.affiliation: Department of Biomedical Magnetic Resonance, University of Tübingen, Otfried-Müller-Str. 51, 72076 Tübingen, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Krüger
authors.affiliation: Department of Biomedical Magnetic Resonance, University of Tübingen, Otfried-Müller-Str. 51, 72076 Tübingen, Germany; University Clinic for Psychiatry and Psychotherapy, University of Tübingen, Calwer Str. 14, 72076 Tübingen, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Schwarz
authors.affiliation: Department of Biomedical Magnetic Resonance, University of Tübingen, Otfried-Müller-Str. 51, 72076 Tübingen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Erb
authors.affiliation: Department of Biomedical Magnetic Resonance, University of Tübingen, Otfried-Müller-Str. 51, 72076 Tübingen, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Kardatzki
authors.affiliation: Department of Biomedical Magnetic Resonance, University of Tübingen, Otfried-Müller-Str. 51, 72076 Tübingen, Germany; Max-Planck-Institute for Biological Cybernetics, Speemannstraße 38-40, 72076 Tübingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Scheffler
authors.affiliation: Department of Biomedical Magnetic Resonance, University of Tübingen, Otfried-Müller-Str. 51, 72076 Tübingen, Germany; University Clinic for Psychiatry and Psychotherapy, University of Tübingen, Calwer Str. 14, 72076 Tübingen, Germany; Max-Planck-Institute for Biological Cybernetics, Speemannstraße 38-40, 72076 Tübingen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ethofer
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D032882:Comprehension / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009146:Music; D009415:Nerve Net / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*; D013067:Speech Perception / Q000502:physiology*; D013647:Task Performance and Analysis
keywords: Connectivity; DWI; Lyrics; Misperception; Music; fMRI