title: Comparative analysis of the effects combined physical procedures and alpha-lipoic acid on the electroneurographic parameters of patients with distal sensorimotor diabetic polyneuropathy.
abstract: [Purpose] Painful diabetic polyneuropathy occurs as a complication in 16% of all patients with diabetes mellitus. [Subjects and Methods] A clinical, prospective open-label randomized intervention study was conducted of 60 adult patients, with distal sensorimotor diabetic neuropathy two groups of 30 patients, with diabetes mellitus type 2 with distal sensorimotor diabetic neuropathy. Patients in group A were treated with combined physical procedures, and patients in group B were treated with alpha lipoic acid. [Results] There where a statistically significant improvements in terminal latency and the amplitude of the action potential in group A patients, while group B patients showed a statistically significant improvements in conduction velocity and terminal latency of n. peroneus. Group A patients showed a statistically significant improvements in conduction velocity and terminal latency, while group B patients also showed a statistically significant improvements in conduction velocity and terminal latency. This was reflected in a significant improvements in electrophysiological parameters (conduction velocity, amplitude and latency) of the motor and sensory nerves (n. peroneus, n. suralis). [Conclusion] These results present further evidence justifying of the use of physical agents in the treatment of diabetic sensorimotor polyneuropathy.
authors.affiliation: Center for Physical Medicine and Rehabilitation, Clinical Center Kragujevac, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Grbovic
authors.affiliation: Center for Physical Medicine and Rehabilitation, Clinical Center Kragujevac, Serbia; Faculty of Medical Sciences, University of Kragujevac, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jurisic-Skevin
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Serbia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Djukic
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Serbia.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Stefanović
authors.affiliation: Center for Physical Medicine and Rehabilitation, Clinical Center Kragujevac, Serbia; Department of Biomedical Sciences, State University of Novi Pazar, Serbia.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Nurkovic
keywords: Diabetic polyneuropathy; Physical procedures