title: Complete Sequence of the FII Plasmid p42-2, Carrying blaCTX-M-55, oqxAB, fosA3, and floR from Escherichia coli.
abstract: We sequenced a novel conjugative multidrug resistance IncF plasmid, p42-2, isolated from Escherichia coli strain 42-2, previously identified in China. p42-2 is 106,886 bp long, composed of a typical IncFII-type backbone (∼54 kb) and one distinct acquired DNA region spanning ∼53 kb, harboring 12 antibiotic resistance genes [blaCTX-M-55, oqxA, oqxB, fosA3, floR, tetA(A), tetA(R), strA, strB, sul2, aph(3')-II, and ΔblaTEM-1]. The spread of these multidrug resistance determinants on the same plasmid is of great concern and, because of coresistance to antibiotics from different classes, is therapeutically challenging.
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
authors.forename: Qiu E
authors.initials: QE
authors.lastname: Yang
authors.affiliation: Department of Medical Microbiology, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
authors.forename: Timothy Rutland
authors.initials: TR
authors.lastname: Walsh
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
authors.forename: Bao Tao
authors.initials: BT
authors.lastname: Liu
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
authors.forename: Meng Ting
authors.initials: MT
authors.lastname: Zou
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Deng
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
authors.forename: Liang Xing
authors.initials: LX
authors.lastname: Fang
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
authors.forename: Xiao Ping
authors.initials: XP
authors.lastname: Liao
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China gale@scau.edu.cn jiansun@scau.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.affiliation: National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, People's Republic of China gale@scau.edu.cn jiansun@scau.edu.cn.
authors.forename: Ya Hong
authors.initials: YH
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases