title: Novel indexes for diagnosing metabolic syndrome in apparently healthy Gujarati Asian Indians: a cross-sectional study.
abstract: BACKGROUND
  We aimed to compare the diagnostic accuracy of four novel indexes-triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, weight height ratio (WHtR), lipid accumulation product (LAP) and visceral adiposity index (VAI) with conventional components of metabolic syndrome (MetS) in order to identify a single index for the diagnosis of MetS in Gujarati Indian population.
  
  
  METHODS
  This observational and cross sectional study involved a total of 3329 healthy adults of 18-79 years of age. Demographic and clinical data such as body mass index, waist circumference, blood pressure were measured along with the levels of lipids and fasting blood glucose.
  
  
  RESULTS
  The overall prevalence of MetS was 34.32%, which was almost double in older individuals (45.5% vs. 20.8%) and slightly higher in males (37% vs. 31.2%). In comparison to individual components of MetS, three novel indexes-VAI, LAP and TG/HDL-C ratio showed superior diagnostic efficacy yielding an area under curve of 0.856, 0.821 and 0.821 respectively. The optimal cut-offs for VAI, LAP and TG/HDL Ratios for male, females, young and old population are (79.71, 88.12, 75.42, 87.4), (35.62, 34.73, 35.88, 34.7) and (2.249, 3.16, 2.49, 2.79) respectively. The diagnostic effectiveness of novel markers was unaffected by the age and gender of an individual. However, the efficacy of WHtR was comparable with the other conventional markers.
  
  
  CONCLUSIONS
  Three novel markers-LAP, VAI and TG/HDL-C ratio could be effectively used as a single 'Surrogate marker' for screening of asymptomatic Gujarati Asian Indians with MetS.
authors.affiliation: From the Department of Cardiology drhasit@yahoo.com.
authors.forename: Hasit
authors.initials: H
authors.lastname: Joshi
authors.affiliation: Department of Research, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Asarwa, Ahmedabad 380016, India.
authors.forename: Komal
authors.initials: K
authors.lastname: Shah
authors.affiliation: Department of Research, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Asarwa, Ahmedabad 380016, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Patel
authors.affiliation: From the Department of Cardiology.
authors.forename: Jayesh
authors.initials: J
authors.lastname: Prajapati
authors.affiliation: From the Department of Cardiology.
authors.forename: Meena
authors.initials: M
authors.lastname: Parmar
authors.affiliation: From the Department of Cardiology.
authors.forename: Dhaval
authors.initials: D
authors.lastname: Doshi
authors.affiliation: From the Department of Cardiology.
authors.forename: Shardul
authors.initials: S
authors.lastname: Chaurushia
mesh_terms: D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000886:Anthropometry / Q000379:methods; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007194:India / Q000453:epidemiology; D064237:Lipid Accumulation Product / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides