title: Comparative In Vitro Activities of Oritavancin, Dalbavancin, and Vancomycin against Methicillin-Resistant Staphylococcus aureus Isolates in a Nondividing State.
abstract: Antibacterial agents that kill nondividing bacteria may be of utility in treating persistent infections. Oritavancin and dalbavancin are bactericidal lipoglycopeptides that are approved for acute bacterial skin and skin structure infections in adults caused by susceptible Gram-positive pathogens. Using time-kill methodology, we demonstrate that oritavancin exerts bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) isolates that are maintained in a nondividing state in vitro, whereas dalbavancin and the glycopeptide vancomycin do not.
authors.affiliation: The Medicines Company, Ville St-Laurent, Quebec, Canada adam.belley@themedco.com.
authors.forename: Adam
authors.initials: A
authors.lastname: Belley
authors.affiliation: The Medicines Company, Ville St-Laurent, Quebec, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Lalonde Seguin
authors.affiliation: The Medicines Company, Ville St-Laurent, Quebec, Canada.
authors.forename: Francis
authors.initials: F
authors.lastname: Arhin
authors.affiliation: The Medicines Company, Ville St-Laurent, Quebec, Canada.
authors.forename: Greg
authors.initials: G
authors.lastname: Moeck
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006020:Glycopeptides / Q000494:pharmacology*; D000077427:Lipoglycopeptides; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D017334:Teicoplanin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology* / Q000031:analogs & derivatives
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D000077427:Lipoglycopeptides; D017334:Teicoplanin; D014640:Vancomycin; C469289:dalbavancin; C100708:oritavancin