title: Wnt Signaling: Role in Regulation of Haematopoiesis.
abstract: Hematopoietic stem cells (HSCs) are a unique population of bone marrow cells which are responsible for the generation of various blood cell lineages. One of the significant characteristics of these HSCs is to self-renew, while producing differentiating cells for normal hematopoiesis. Deregulation of self-renewal and differentiation leads to the hematological malignancies. Several pathways are known to be involved in the maintenance of HSC fate among which Wnt signaling is a crucial pathway which controls development and cell fate determination. Wnt signaling also plays a major role in differentiation, self-renewal and maintenance of HSCs. Wnt ligands activate three major pathways including planar cell polarity, Wnt/β-catenin and Wnt/Ca(2+). It has been shown that Wnt/β-catenin or canonical pathway regulates cell proliferation, survival and differentiation in HSCs, deregulation of this pathway leads to hematological malignancies. Wnt non-canonical pathway regulates calcium signaling and planar cell polarity. In this review, we discuss various signaling pathways induced by Wnt ligands and their potential role in hematopoiesis.
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana 500046 India.
authors.forename: Ram Babu
authors.initials: RB
authors.lastname: Undi
authors.affiliation: Department of Biotechnology, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh 530 045 India.
authors.forename: Usha
authors.initials: U
authors.lastname: Gutti
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana 500046 India.
authors.forename: Itishri
authors.initials: I
authors.lastname: Sahu
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana 500046 India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Sarvothaman
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana 500046 India.
authors.forename: Satya Ratan
authors.initials: SR
authors.lastname: Pasupuleti
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana 500046 India.
authors.forename: Ravinder
authors.initials: R
authors.lastname: Kandi
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana 500046 India.
authors.forename: Ravi Kumar
authors.initials: RK
authors.lastname: Gutti
keywords: Planar cell polarity; Wnt/Ca2+; Wnt/β-catenin