title: Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy.
abstract: A novel functional-genomics based concept of pharmacology that uses artificial intelligence techniques for mining and knowledge discovery in "big data" providing comprehensive information about the drugs' targets and their functional genomics is proposed. In "process pharmacology", drugs are associated with biological processes. This puts the disease, regarded as alterations in the activity in one or several cellular processes, in the focus of drug therapy. In this setting, the molecular drug targets are merely intermediates. The identification of drugs for therapeutic or repurposing is based on similarities in the high-dimensional space of the biological processes that a drug influences. Applying this principle to data associated with lymphoblastic leukemia identified a short list of candidate drugs, including one that was recently proposed as novel rescue medication for lymphocytic leukemia. The pharmacological data science approach provides successful selections of drug candidates within development and repurposing tasks.
authors.affiliation: Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany.|Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Frankfurt am Main, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Lötsch
authors.affiliation: DataBionics Research Group, University of Marburg, Marburg, Germany.
authors.forename: Alfred
authors.initials: A
authors.lastname: Ultsch
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001185:Artificial Intelligence; D055808:Drug Discovery / Q000379:methods*; D058492:Drug Repositioning; D023281:Genomics; D006801:Humans; D058990:Molecular Targeted Therapy; D000069437:Pharmacological Phenomena; D010600:Pharmacology / Q000379:methods*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics; D049490:Systems Biology
chemical_list: D000700:Analgesics; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents