title: A Prospective Randomized Controlled Study of Laser-Assisted Hatching on the Outcome of First Fresh IVF-ET Cycle in Advanced Age Women.
abstract: There is no sufficient data to conclude the benefit of assisted hatching (AH) for advanced age patients. However, AH is routinely performed for advanced age patients undergoing in vitro fertilization (IVF) in China based on some retrospective evidence. It is important to assess the benefit of AH procedure for advanced age patients, especially by analyzing the data from China. This is a prospective randomized controlled trial to evaluate the effect of laser AH in the advanced age patients undergoing IVF. A total of 256 patients conformed to the inclusion criteria, and 78 were excluded by exclusion criteria. A total of 178 patients were eligible and randomized to 2 groups (82 AH group and 96 control group). Laser AH (zona thinning) was performed in the AH group. There were no statistical significance in basic clinical parameters between the 2 groups. No difference was found in implantation rate (AH vs control, 32.45% vs 39.29%) and clinical pregnancy rate (AH vs control, 48.78% vs 59.38%). Our data did not find any benefit of laser AH in improving implantation or pregnancy rates in advanced age women. Due to the potential risk and increasing financial burden, AH should not be routinely performed in first fresh IVF embryo transfer cycle for advanced age women.
authors.affiliation: Assisted Reproduction Center, Northwest women and children's Hospital, Xi'an, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Shi
authors.affiliation: Obstetrics and Gynecology Department, Northwest women and children's Hospital, Xi'an, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Hongwei
authors.affiliation: Respiratory Internal Medicine, Shaanxi Provincial People's Hospital, Xi'an, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Assisted Reproduction Center, Northwest women and children's Hospital, Xi'an, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Assisted Reproduction Center, Northwest women and children's Hospital, Xi'an, China.
authors.forename: Mingzhao
authors.initials: M
authors.lastname: Li
authors.affiliation: Assisted Reproduction Center, Northwest women and children's Hospital, Xi'an, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Assisted Reproduction Center, Northwest women and children's Hospital, Xi'an, China shijuanzi123@126.com.
authors.forename: Juanzi
authors.initials: J
authors.lastname: Shi
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D015044:Zona Pellucida / Q000528:radiation effects
keywords: advanced age women; assisted hatching; in vitro fertilization; zona pellucida