title: Case of metachronous bilateral isolated adrenal metastasis from colorectal adenocarcinoma and review of the literature.
abstract: Rarely has a solitary, metachronous bilateral adrenal metastasis of colorectal cancer been reported. We depict a 41-year-old man who underwent sigmoid colon cancer radical surgery followed by adjuvant chemotherapy for a locally ulcerative sigmoid adenocarcinoma with metachronous bilateral adrenal metastasis revealed by a computed tomography scan. Histopathological examination showed adenocarcinoma, compatible with metastasis from the rectal cancer. The level of serum carcinoembryonic antigen had indicative significance for the presence of adrenal metastasis in the reported series. We performed a literature analysis related to this pathological characteristic and attach importance to consistent, vigilant radiological surveillance of the adrenal glands in the patients' follow up for colorectal cancer with or without subsequent adrenal metastasis.
authors.affiliation: Yu-Yi Liu, Zhi-Hui Chen, Er-Tao Zhai, Jie Yang, Jian-Bo Xu, Shi-Rong Cai, Wu Song, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors.forename: Yu-Yi
authors.initials: YY
authors.lastname: Liu
authors.affiliation: Yu-Yi Liu, Zhi-Hui Chen, Er-Tao Zhai, Jie Yang, Jian-Bo Xu, Shi-Rong Cai, Wu Song, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Chen
authors.affiliation: Yu-Yi Liu, Zhi-Hui Chen, Er-Tao Zhai, Jie Yang, Jian-Bo Xu, Shi-Rong Cai, Wu Song, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors.forename: Er-Tao
authors.initials: ET
authors.lastname: Zhai
authors.affiliation: Yu-Yi Liu, Zhi-Hui Chen, Er-Tao Zhai, Jie Yang, Jian-Bo Xu, Shi-Rong Cai, Wu Song, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: Yu-Yi Liu, Zhi-Hui Chen, Er-Tao Zhai, Jie Yang, Jian-Bo Xu, Shi-Rong Cai, Wu Song, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Xu
authors.affiliation: Yu-Yi Liu, Zhi-Hui Chen, Er-Tao Zhai, Jie Yang, Jian-Bo Xu, Shi-Rong Cai, Wu Song, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Cai
authors.affiliation: Yu-Yi Liu, Zhi-Hui Chen, Er-Tao Zhai, Jie Yang, Jian-Bo Xu, Shi-Rong Cai, Wu Song, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Song
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D002272:Carcinoembryonic Antigen / Q000097:blood; D017024:Chemotherapy, Adjuvant; D003082:Colectomy; D006801:Humans; D008297:Male; D012086:Reoperation; D012811:Sigmoid Neoplasms / Q000097:blood / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D002272:Carcinoembryonic Antigen
keywords: Adrenal gland; Bilateral; Colorectal cancer; Metachronous; Metastasis