title: Synchronous intramolecular cycloadditions of the polyene macrolactam polyketide heronamide C.
abstract: A growing number of natural products appear to arise from biosynthetic pathways that involve pericyclic reactions. We show here that for the heronamides this can occur via two spontaneous pathways involving alternative thermal or photochemical intramolecular cycloadditions.
authors.affiliation: Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. barrie.wilkinson@jic.ac.uk.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Booth
authors.forename: Silke
authors.initials: S
authors.lastname: Alt
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
authors.forename: Barrie
authors.initials: B
authors.lastname: Wilkinson
mesh_terms: D061565:Cycloaddition Reaction; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D055668:Photochemical Processes; D013302:Streptomyces / Q000737:chemistry
chemical_list: D047029:Lactams, Macrocyclic; C555720:heronamide C