title: Possible Involvement of Adiponectin, the Anti-Diabetes Molecule, in the Pathogenesis of Alzheimer's Disease.
abstract: Adiponectin (APN) is protective in animal models of neurodegenerative diseases, but the role of APN in human brain has not been established. Using an enzyme-linked immunosorbent assay, we found that APN was significantly decreased in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD), compared to those in patients with mild cognitive impairment (MCI) and in normal controls (NC), despite elevation of APN in serum of patients with MCI and AD compared to that in NC. The discrepancy of CSF APN from serum APN in AD may suggest some critical actions of APN in the pathogenesis of AD. Indeed, it was histologically observed that APN was co-localized with tau in neurofibrillary tangles and immunoblot analysis showed that the functional trimers of APN were significantly decreased in AD compared to those in NC. Collectively, a loss of function of APN may be involved in the pathogenesis of AD.
authors.affiliation: Department of Neurology, Higashi Matsudo Municipal Hospital, Matsudo-shi, Chiba, Japan.|Tokyo Metropolitan Institute of Medical Sciences, Setagaya-ku, Tokyo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Waragai
authors.affiliation: Department of Neurosciences, University of California, San Diego, CA, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Adame
authors.affiliation: Department of Neurosciences, University of California, San Diego, CA, USA.
authors.forename: Ivy
authors.initials: I
authors.lastname: Trinh
authors.affiliation: Tokyo Metropolitan Institute of Medical Sciences, Setagaya-ku, Tokyo, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Sekiyama
authors.affiliation: Tokyo Metropolitan Institute of Medical Sciences, Setagaya-ku, Tokyo, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Takamatsu
authors.affiliation: Department of Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Une
authors.affiliation: Department of Neurosciences, University of California, San Diego, CA, USA.
authors.forename: Eliezer
authors.initials: E
authors.lastname: Masliah
authors.affiliation: Tokyo Metropolitan Institute of Medical Sciences, Setagaya-ku, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
mesh_terms: D052242:Adiponectin / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000172:deficiency; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000473:pathology; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000097:blood / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; Alzheimer’s disease; cerebrospinal fluid; neurofibrillary tangles; sequestration; serum; tau