title: Platelet Reactivity Is Independent of Left Atrial Wall Deformation in Patients with Atrial Fibrillation.
abstract: It has been documented recently that left atrial (LA) deformation in AF patients (while in AF) is predictive of subsequent stroke risk. Additionally, diminished LA deformation during AF correlates with the presence of LA blood stasis. Given that endothelial function is dependent on laminar blood flow, the present study sought to investigate the effect of diminished LA deformation (during AF) on platelet reactivity and inflammation in AF patients. Patients (n = 17) hospitalised with AF underwent echocardiography (while in AF) for determination of peak positive LA strain (LASp). Whole blood impedance aggregometry was used to measure extent of ADP-induced aggregation and subsequent inhibitory response to the nitric oxide (NO) donor, sodium nitroprusside. Platelet thioredoxin-interacting protein (Txnip) content was determined by immunohistochemistry. LASp tended (p = 0.078) to vary inversely with CHA2DS2VASc scores. However, mediators of inflammation (C-reactive protein, Txnip) did not correlate significantly with LASp nor did extent of ADP-induced platelet aggregation or platelet NO response. These results suggest that the thrombogenic risk associated with LA stasis is independent of secondary effects on platelet aggregability or inflammation.
authors.affiliation: Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, SA 5011, Australia.
authors.forename: Nathan
authors.initials: N
authors.lastname: Procter
authors.affiliation: Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, SA 5011, Australia.
authors.forename: Vincent
authors.initials: V
authors.lastname: Goh
authors.affiliation: Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, SA 5011, Australia.
authors.forename: Gnanadevan
authors.initials: G
authors.lastname: Mahadevan
authors.affiliation: National Health and Medical Research Council Centre of Research Excellence to Reduce Inequality in Heart Disease, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC 3065, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Stewart
authors.affiliation: Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, SA 5011, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Horowitz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D002352:Carrier Proteins; C486715:TXNIP protein, human