title: Expression of COX-2 and p53 in juvenile polyposis coli and its correlation with adenomatous changes.
abstract: BACKGROUND
  Gastrointestinal polyps commonly affect the pediatric population. The commoner variety amongst these is the solitary rectal polyp. Juvenile polyposis coli (JPC) is rare, characterized by multiple polyps occurring throughout the gut.
  
  
  OBJECTIVE
  The role of cyclooxygenase-2 (COX-2) has been implicated in gastrointestinal tumorigenesis. We aimed to look at the clinicopathological spectrum of solitary vs juvenile polyposis and compare their differences in expression of COX-2 and p53.
  
  
  METHODS
  We studied 38 polyps from eight cases of JPC, collected over the past 10 years along with 40 solitary rectal polyps (SRP).
  
  
  RESULTS
  The size of polyps was significantly more in cases of JPC compared to SRP. Adenomatous change was observed significantly more often in JPC. COX-2 expression was also significantly higher in the JPC group compared to SRPs. All cases of JPC polyps with adenomatous change showed strong COX-2 expression. There was no significant difference in expression of p53 in the JPC and SRP groups.
  
  
  CONCLUSIONS
  We observed significantly higher COX-2 expression in JPC. Establishment of the role of COX-2 in JPC will help us formulate chemopreventive therapies as an adjunct to its surgical management.
authors.forename: Shatavisha Das
authors.initials: SD
authors.lastname: Gupta
authors.forename: Ram Narayan
authors.initials: RN
authors.lastname: Das
authors.forename: Ranajoy
authors.initials: R
authors.lastname: Ghosh
authors.forename: Anway
authors.initials: A
authors.lastname: Sen
authors.affiliation: Department of Pathology, The Institute of Post-Graduate Medical Education and Research, Kolkata, West Bengal, India.
authors.forename: Uttara
authors.initials: U
authors.lastname: Chatterjee
authors.forename: Kaushik
authors.initials: K
authors.lastname: Saha
authors.forename: Chhanda
authors.initials: C
authors.lastname: Datta
authors.forename: Prafulla Kumar
authors.initials: PK
authors.lastname: Mishra
authors.forename: Ranjana
authors.initials: R
authors.lastname: Bandyopadhyay
mesh_terms: D000293:Adolescent; D063646:Carcinogenesis / Q000235:genetics*; D002648:Child; D051546:Cyclooxygenase 2 / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D044483:Intestinal Polyposis / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D008297:Male; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human