title: Association of IL28B and IL10 gene polymorphism with predisposition to tick-borne encephalitis in a Russian population.
abstract: Genetic predisposition to tick-borne encephalitis (TBE) is rather poorly studied in human populations. Human genes encoding crucial components of antiviral immune response are most likely involved in protective mechanisms against TBE virus. Previously, several single nucleotide polymorphisms (SNPs) located in interleukin 28B (IL28B) and interleukin 10 (IL10) genes were associated with predisposition to chronic hepatitis C (caused by a structurally similar virus from the same Flaviviridae family) in a number of human populations. The aim of the present study was to estimate a possible association of the IL28B gene rs8103142 and rs12980275 SNPs and IL10 gene rs1800872, rs3021094, and rs3024498 SNPs with predisposition to TBE in a Russian population. Genotypic and allelic frequencies for these SNPs were analyzed in 132 non-immunized TBE patients (34 with fever, 60 with meningitis, and 38 with severe central nervous system disease) and compared with the population control (221 Novosibirsk citizens). The results obtained suggest that both studied IL28B gene SNPs, as well as the IL10 gene rs1800872 SNP are associated with predisposition to TBE in Russian population.
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090 Russia. Electronic address: barkhash@bionet.nsc.ru.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Barkhash
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090 Russia; Novosibirsk State University, 2 Pirogova str., Novosibirsk 630090 Russia.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Babenko
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090 Russia; Novosibirsk State University, 2 Pirogova str., Novosibirsk 630090 Russia; Institute of Internal and Preventive Medicine, 175/1 B. Bogatkova str., Novosibirsk 630089 Russia.
authors.forename: Mikhail I
authors.initials: MI
authors.lastname: Voevoda
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090 Russia.
authors.forename: Aida G
authors.initials: AG
authors.lastname: Romaschenko
mesh_terms: D000483:Alleles; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007372:Interferons; D016753:Interleukin-10 / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012426:Russia / Q000453:epidemiology; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D016753:Interleukin-10; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C508609:IL10 protein, human
keywords: Human genetic predisposition; Interleukin 10 (IL10) gene; Interleukin 28B (IL28B) gene; Single nucleotide polymorphism (SNP); Tick-borne encephalitis (TBE)