title: Risk Factors Associated With Increased Carotid Intima-Media Thickness in a Male Population With Chronic Alcohol Consumption: A Prospective Observational Study.
abstract: Previous studies have reported a relationship between alcohol consumption and carotid intima-media thickness (CIMT). However, the exact associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption remain unknown. The aim of this study was to explore whether there are associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption. We enrolled 173 males with chronic alcohol consumption and categorized them into 2 groups: 104 chronic alcohol consumers with normal CIMT (group A) and 69 chronic alcohol consumers with increased CIMT (group B). Nonparametric statistics showed that age, body mass index (BMI), and serum TC, TG, Apo A1, and ApoB levels were significantly higher in group B than in group A (P = 0.002, 0.019, 0.021, 0.023, 0.001, and 0.001, respectively). Additionally, tumor necrosis factor alpha (TNFα) and HSP70 serum levels were significantly lower in group B than in group A (P = 0.023 and 0.017, respectively). A binary logistic regression analysis showed that age (OR: 1.077, 95% CI: 1.024-1.13, P = 0.004), ApoB (OR: 6.828, 95% CI: 1.506-30.956, P = 0.013), and TNF-α (OR: 0.999, 95% CI: 0.998-1.00) were independent risk factors associated with CIMT. The present study demonstrated that age, ApoB, and TNFα are independent risk factors associated with CIMT. Thus, older subjects with increased serum ApoB levels are more likely to present with increased CIMT, suggesting that age and ApoB promote such thickening and that TNFα downregulation might play a protective role against the progression of subclinical atherosclerosis in subjects with chronic alcohol consumption.
authors.affiliation: From the Department of Internal Medicine, Taishan Hospital of Shandong Province; Taishan Medical College, Taian, Shandong (BQ, YL, YJ, XH, JS, HW, LL, ZW, YW, JP, GR); and Zhuhai Campus of Zunyi Medical College, Zhuhai, Guangdong, China (TQ).
authors.forename: Baoge
authors.initials: B
authors.lastname: Qu
authors.forename: Tao
authors.initials: T
authors.lastname: Qu
authors.forename: Yuanxun
authors.initials: Y
authors.lastname: Liu
authors.forename: Yiguo
authors.initials: Y
authors.lastname: Jia
authors.forename: Xinghai
authors.initials: X
authors.lastname: Han
authors.forename: Jiliang
authors.initials: J
authors.lastname: Su
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Lili
authors.initials: L
authors.lastname: Liu
authors.forename: Zhongdong
authors.initials: Z
authors.lastname: Wang
authors.forename: Yafei
authors.initials: Y
authors.lastname: Wang
authors.forename: Jindun
authors.initials: J
authors.lastname: Pan
authors.forename: Guangying
authors.initials: G
authors.lastname: Ren
mesh_terms: D000328:Adult; D000367:Age Factors; D000437:Alcoholism / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D001055:Apolipoproteins B / Q000097:blood*; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D002681:China / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D011446:Prospective Studies; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha