title: ROQUIN signalling pathways in innate and adaptive immunity.
abstract: ROQUIN is an RNA-binding protein that plays important roles in both the innate and adaptive immune systems. ROQUIN binds to several key immune-relevant messenger RNA (mRNA) targets through its ROQ domain modulating their stability and influencing macrophage function and the peripheral homeostasis of T cells and B cells. More recently, the E3 ubiquitin ligase activity of the ROQUIN RING domain has been shown to be crucial for T-cell-dependent B-cell responses against infection. Defective ROQUIN activity can culminate in a range of diseases, such as systemic autoimmunity, immunodeficiency, and inflammatory bowel disorder. Here, we provide a current overview of the immunomodulatory role of ROQUIN defined by its ribonucleoprotein-like structure, its repertoire of mRNA targets shared by related RNA-binding enzymes, and its involvement in a range of intracellular signalling pathways central to shaping immune responses.
authors.affiliation: John Curtin School of Medical Research, Australian National University, Canberra, Australia.
authors.forename: Vicki
authors.initials: V
authors.lastname: Athanasopoulos
authors.affiliation: John Curtin School of Medical Research, Australian National University, Canberra, Australia.
authors.forename: Roybel R
authors.initials: RR
authors.lastname: Ramiscal
authors.affiliation: John Curtin School of Medical Research, Australian National University, Canberra, Australia.
authors.forename: Carola G
authors.initials: CG
authors.lastname: Vinuesa
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D012313:RNA; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: C000592051:RC3H1 protein, human; D012333:RNA, Messenger; C013674:RNA, immune; D016601:RNA-Binding Proteins; D012313:RNA; D044767:Ubiquitin-Protein Ligases
keywords: B cells; Macrophages; ROQUIN; T cells; mRNA