title: Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement.
abstract: The International Pancreas and Islet Transplant Association (IPITA), in conjunction with the Transplantation Society (TTS), convened a workshop to consider the future of pancreas and islet transplantation in the context of potential competing technologies that are under development, including the artificial pancreas, transplantation tolerance, xenotransplantation, encapsulation, stem cell derived beta cells, beta cell proliferation, and endogenous regeneration. Separate workgroups for each topic and then the collective group reviewed the state of the art, hurdles to application, and proposed research agenda for each therapy that would allow widespread application. Herein we present the executive summary of this workshop that focuses on obstacles to application and the research agenda to overcome them; the full length article with detailed background for each topic is published as an online supplement to Transplantation.
authors.affiliation: 1 Division of Transplantation, Massachusetts General Hospital, Boston, MA. 2 Department of Surgery, University of Maryland School of Medicine, Baltimore, MD. 3 Nuffield Department of Surgical Sciences and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom. 4 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. 5 Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN. 6 Prodo Laboratories, LLC, Irvine, CA. 7 The Scharp-Lacy Research Institute, Irvine, CA. 8 St. Vincent's Institute of Medical Research, Victoria, Australia. 9 Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Victoria, Australia. 10 Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI. 11 Joslin Diabetes Center and Harvard Medical School, Boston MA. 12 National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. 13 Division of Transplantation, University of San Francisco Medical Center, San Francisco, CA. 14 Department of Surgery, Fukushima Medical University, Fukushima, Japan. 15 Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA. 16 Xenotransplantation Research Center, Department of Microbiology and Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea. 17 The Center for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia. 18 Department of Biomedical Engineering, University of Florida, Gainesville, FL. 19 Otsuka Pharmaceutical Factory inc, Naruto Japan. 20 National Center for Global Health and Medicine, Tokyo, Japan. 21 Department of Medicine III, Technische Universität Dresden, Dresden, Germany. 22 Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic
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mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003226:Congresses as Topic; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007328:Insulin / Q000008:administration & dosage; D050417:Insulin-Secreting Cells / Q000166:cytology*; D007515:Islets of Langerhans / Q000378:metabolism; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D010179:Pancreas / Q000378:metabolism; D016035:Pancreas Transplantation / Q000379:methods*; D012038:Regeneration; D012955:Societies, Medical; D013552:Swine; D014183:Transplantation, Heterologous / Q000379:methods; D014184:Transplantation, Homologous; D014481:United States
chemical_list: D007328:Insulin