title: Hypoxia-inducible factor 1 in autoimmune diseases.
abstract: Autoimmune disorders are a complicated and varied group of diseases arising from inappropriate immune responses. Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which hypoxia-inducible factor 1 (HIF-1), an oxygen-sensitive transcription factor that allows adaptation to hypoxia environments, has been shown to play an important function. HIF-1 is a regulator of angiogenesis and immune system. Besides, HIF-1-mediated metabolic shift and fibrosis may also play crucial roles in some autoimmune disorders. Firstly, we briefly summarize the role of HIF-1 in angiogenesis, immune responses and fibrosis. Secondly, we will show the major recent findings demonstrating a role for HIF-1 signaling in autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, systemic sclerosis and multiple sclerosis. The growing evidences may prompt HIF-1 to be a new target for treatment of autoimmune diseases.
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, PR China.
authors.forename: Xuebing
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, PR China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, PR China. Electronic address: lingyunsun@nju.edu.cn.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Sun
mesh_terms: D043924:Angiogenesis Modulating Agents / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D063646:Carcinogenesis; D004730:Endothelium, Vascular / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000276:immunology / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D010084:Oxidation-Reduction; D015398:Signal Transduction
chemical_list: D043924:Angiogenesis Modulating Agents; D051793:Hypoxia-Inducible Factor 1; D018836:Inflammation Mediators
keywords: Fibrosis; HIF-1; Immune responses; Inflammation; Metabolism; Neovascularization