title: Up-regulated expression of scavenger receptor class B type 1 (SR-B1) is associated with malignant behaviors and poor prognosis of breast cancer.
abstract: Scavenger receptor class B type 1 (SR-B1) is an integral membrane protein that is expressed in numerous cells and tissue types. The primary role of SR-B1 is to facilitate uptake of cholesteryl esters from high-density lipoproteins (HDL) in the liver. Altered SR-B1 expression contributes to human diseases. This study assessed association of SR-B1 expression in breast tissue specimens with breast cancer development and prognosis. Tissue specimens from 30 cases of adjacent normal breast tissues, ductal carcinoma in situ (DCIS) and invasive ductal breast cancer (IDCA) were subjected to Western blot analysis, and 135 cases of DCIS and IDCA were used for quantitative immunohistochemical analysis of SR-B1 expression. The data showed that SR-B1 was significantly overexpressed in IDCA tissues compared to normal breast and DCIS tissues. SR-B1 expression was associated with pre-menopausal status, tumor size, and worse overall survival of patients. The data from this ex vivo study suggests that up-regulated SR-B1 protein expression is associated with malignant behaviors of breast cancer and that SR-B1 is an independent predictor for poor survival in breast cancer patients.
authors.affiliation: Department of Pathology, Shandong University School of Medicine, Jinan, Shandong 250012, China; Department of Pathology, The Fourth Hospital of Jinan, Jinan, Shandong 250031, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, The Fourth Hospital of Jinan, Jinan, Shandong 250031, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Chest Surgery, The Chest Hospital of Shandong, Jinan, Shandong 250000, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Oncology, The Fourth Hospital of Jinan, Jinan, Shandong 250031, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Pediatrics, Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: xli2@email.uky.edu.
authors.forename: Xiang-An
authors.initials: XA
authors.lastname: Li
authors.affiliation: Department of Pathology, Shandong University School of Medicine, Jinan, Shandong 250012, China. Electronic address: ztguo@sdu.edu.cn.
authors.forename: Ting-Guo
authors.initials: TG
authors.lastname: Zhang
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018955:CD36 Antigens / Q000235:genetics*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D015854:Up-Regulation
chemical_list: D018955:CD36 Antigens
keywords: Biomarker; Breast cancer; Prognosis; SRB1