title: [The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract].
abstract: Rebamipide is a cytoprotесtive drug that stimulates the generation of endogenous prostaglandins in the gastric and small intestinal mucosa and accelerates the healing of erosions and ulcers caused by Helicobacter pylori infection and NSAID administration. The major properties of rebamipide include stimulation of prostaglandins and synthesis of muсus glycoproteins, inhibition of reactive oxygen species, inflammatory cytokines, and chemokines, and suppression of neutrophil activation. This paper shows the ability of rebamipide to enhance the efficiency of therapy for Helicobacter pylori-induced infection, to reduce inflammation, including that after infection eradication, to accelerate ulcer healing, and to prevent the progression of preneoplastic lesions.
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Yakovenko
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Agafonova
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanov
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Yakovenko
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Aldiyarova
authors.affiliation: Clinical Hospital, Department for Presidential Affairs of the Russian Federation, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Volosheinikova
authors.affiliation: Clinical Hospital, Department for Presidential Affairs of the Russian Federation, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Grigoryeva
authors.affiliation: Amusk State Medical Academy, Ministry of Health of Russia, Blagoveshchensk, Amursk Region.
authors.forename: I P
authors.initials: IP
authors.lastname: Soluyanova
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005753:Gastric Mucosa; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D015363:Quinolones / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D015363:Quinolones; C052785:rebamipide; D000409:Alanine