title: Brachytherapy after salvage surgery in cases with large isolated cervical recurrence of squamous cell carcinoma in the previously irradiated neck.
abstract: Perioperative brachytherapy after salvage surgery is a therapeutic option in patients with cervical relapse of a primary, controlled, previously irradiated head and neck squamous cell carcinoma. The purpose of this study was to analyze the outcome of this treatment.
  
  
  
  Between 2008 and 2013, 8 patients underwent cervical brachytherapy after neck dissection. The mean node size was 5.5 cm. Recurrence occurred in an irradiated field (median dose, 50 Gy). Brachytherapy was performed with (192) iridium and dosimetry in accord with the rules of the Paris system. The dose was 60 to 62.7 Gy on the reference isodose.
  
  
  
  The mean follow-up was 17 months. The median overall survival (OS) was 12 months. The OS was 19% at 2 years and 0% at 5 years. A grade 5 postoperative adverse event occurred in 1 patient. At 6 months, all patients had a grade 3 neck soft tissue fibrosis. One patient had a lethal hemorrhage at 56 months.
  
  
  
  Brachytherapy is toxic in this population with poor OS. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2490-E2494, 2016.
authors.affiliation: Department of Radiation Oncology, Centre Jean Perrin, Clermont-Ferrand Cedex, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Miroir
authors.affiliation: Department of Radiation Oncology, Centre Jean Perrin, Clermont-Ferrand Cedex, France.
authors.forename: Julian
authors.initials: J
authors.lastname: Biau
authors.affiliation: Department of Head and Neck Cancer, CHU, Clermont-Ferrand Cedex, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Saroul
authors.affiliation: Department of Radiation Physics, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Moreira
authors.affiliation: Department of Head and Neck Cancer, CHU, Clermont-Ferrand Cedex, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Russier
authors.affiliation: Department of Radiation Oncology, Centre Jean Perrin, Clermont-Ferrand Cedex, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Lapeyre
mesh_terms: D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000379:methods*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: brachytherapy; head and neck cancer; irradiated-fields; reirradiation; surgery