title: Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS).
abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing death of the motor neurons. Proteotoxicity caused by TDP-43 protein is an important aspect of ALS pathogenesis, with TDP-43 being the main constituent of the aggregates found in patients. We have previously tested the effect of different sugars on the proteotoxicity caused by the expression of mutant TDP-43 in Caenorhabditis elegans. Here we tested maple syrup, a natural compound containing many active molecules including sugars and phenols, for neuroprotective activity. Maple syrup decreased several age-dependent phenotypes caused by the expression of TDP-43(A315T) in C. elegans motor neurons and requires the FOXO transcription factor DAF-16 to be effective.
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) , 900 St-Denis Street, Montréal, Québec, Canada H2X 0A9.
authors.forename: Catherine
authors.initials: C
authors.lastname: Aaron
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) , 900 St-Denis Street, Montréal, Québec, Canada H2X 0A9.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Beaudry
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) , 900 St-Denis Street, Montréal, Québec, Canada H2X 0A9.|Department of Neuroscience, University of Montréal , 2960 Chemin de la Tour, Montréal, Québec, Canada H3T 1J4.
authors.forename: J Alex
authors.initials: JA
authors.lastname: Parker
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) , 900 St-Denis Street, Montréal, Québec, Canada H2X 0A9.|Department of Pathology and Cell Biology, University of Montreal , 2900 Edouard-Montpetit Boul, Montréal, Québec, Canada H3T 1J4.
authors.forename: Martine
authors.initials: M
authors.lastname: Therrien
mesh_terms: D031002:Acer / Q000737:chemistry*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans; D004268:DNA-Binding Proteins / Q000633:toxicity*; D004195:Disease Models, Animal; D008401:Gas Chromatography-Mass Spectrometry; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D004268:DNA-Binding Proteins; D010936:Plant Extracts; C000598624:TARDBP protein, human
keywords: ALS; C. elegans; TDP-43; maple syrup