title: Secretory IgA in the Coordination of Establishment and Maintenance of the Microbiota.
abstract: Starting at birth, the intestinal microbiota changes dramatically from a highly individual collection of microorganisms, dominated by comparably few species, to a mature, competitive, and diverse microbial community. Microbial colonization triggers and accompanies the maturation of the mucosal immune system and ultimately results in a mutually beneficial host-microbe interrelation in the healthy host. Here, we discuss the role of secretory immunoglobulin A (SIgA) during the establishment of the infant microbiota and life-long host-microbial homeostasis. We critically review the published literature on how SIgA affects the enteric microbiota and highlight the accessibility of the infant microbiota to therapeutic intervention.
authors.affiliation: Institute of Molecular Medicine, RWTH University, 52074 Aachen, Germany. Electronic address: opabst@ukaachen.de.
authors.forename: Oliver
authors.initials: O
authors.lastname: Pabst
authors.affiliation: Institute of Molecular Medicine, RWTH University, 52074 Aachen, Germany.
authors.forename: Vuk
authors.initials: V
authors.lastname: Cerovic
authors.affiliation: Institute of Medical Microbiology, RWTH University, 52074 Aachen, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Hornef
mesh_terms: D000818:Animals; D001691:Biological Therapy; D000069196:Gastrointestinal Microbiome; D006706:Homeostasis; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D064307:Microbiota
chemical_list: D007070:Immunoglobulin A