title: Promoting intestinal adaptation by nutrition and medication.
abstract: The ultimate goal in the treatment of short bowel syndrome is to wean patients off parenteral nutrition, by promoting intestinal adaptation. Intestinal adaptation is the natural compensatory process that occurs after small bowel resection. Stimulating the remaining bowel with enteral nutrition can enhance this process. Additionally, medication can be used to either reduce factors that complicate the adaptation process or to stimulate intestinal adaptation, such as antisecretory drugs and several growth factors. The aim of this review was to provide an overview of the best nutritional strategies and medication that best promote intestinal adaptation.
authors.affiliation: Department of Paediatric Gastroenterology, Erasmus Medical Center (MC) - Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: e.neelis@erasmusmc.nl.
authors.forename: E G
authors.initials: EG
authors.lastname: Neelis
authors.affiliation: Department of Paediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Dietetics, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: j.olieman@erasmusmc.nl.
authors.forename: J F
authors.initials: JF
authors.lastname: Olieman
authors.affiliation: Department of Paediatric Gastroenterology, Erasmus Medical Center (MC) - Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: j.hulst@erasmusmc.nl.
authors.forename: J M
authors.initials: JM
authors.lastname: Hulst
authors.affiliation: Department of Paediatric Gastroenterology, Erasmus Medical Center (MC) - Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: b.dekoning@erasmusmc.nl.
authors.forename: B A E
authors.initials: BA
authors.lastname: de Koning
authors.affiliation: Department of Paediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: r.wijnen@erasmusmc.nl.
authors.forename: R M H
authors.initials: RM
authors.lastname: Wijnen
authors.affiliation: Department of Paediatric Gastroenterology, Erasmus Medical Center (MC) - Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Paediatric Gastroenterology, Leiden University Medical Center - Willem Alexander Children's Hospital, Leiden, The Netherlands. Electronic address: e.rings@erasmusmc.nl.
authors.forename: E H H M
authors.initials: EH
authors.lastname: Rings
mesh_terms: D000222:Adaptation, Physiological; D004750:Enteral Nutrition; D006801:Humans; D007421:Intestine, Small / Q000503:physiopathology* / Q000601:surgery; D009752:Nutritional Status; D010288:Parenteral Nutrition; D012778:Short Bowel Syndrome / Q000503:physiopathology* / Q000601:surgery
keywords: Enteral nutrition; Growth factors; Intestinal adaptation; Intestinal failure; Parenteral nutrition; Short bowel syndrome