title: Drug release characteristics of quercetin-loaded TiO2nanotubes coated with chitosan.
abstract: TiO2nanotubes formed by anodic oxidation of Ti-6Al-7Nb were loaded with quercetin (TNTQ) and chitosan was coated on the top of the quercetin (TNTQC) to various thicknesses. Field emission scanning electron microscopy (FESEM), 3D and 2D analyses were used to characterize the samples. The drug release studies of TNTQ and TNTQC were studied in Hanks' solution for 192h. The studies showed that the native oxide on the sample is substituted by self assembled nanotube arrays by anodisation. FESEM images of chitosan-loaded TNT samples showed that filling of chitosan takes place in inter-tubular space and pores. Drug release studies revealed that the release of drug into the local environment during that duration was constant. The local concentration of the drug can be controlled and tuned by controlling the thickness of the chitosan (0.6, 1 and 3μm) to fit into an optimal therapeutic window in order to treat postoperative infections, inflammation and for quick healing with better osseointegration of the titanium implants.
authors.affiliation: Surface Engineering Division, CSIR-National Aerospace Laboratories, P.O. Box:1779, Old Airport Road, Bangalore, Karnataka, India; Department of Chemistry, Anna University, Chennai, Tamilnadu, India.
authors.forename: L
authors.initials: L
authors.lastname: Mohan
authors.affiliation: Surface Engineering Division, CSIR-National Aerospace Laboratories, P.O. Box:1779, Old Airport Road, Bangalore, Karnataka, India. Electronic address: canandan@nal.res.in.
authors.forename: C
authors.initials: C
authors.lastname: Anandan
authors.affiliation: Department of Chemistry, Anna University, Chennai, Tamilnadu, India. Electronic address: nrajendran@annauniv.edu.
authors.forename: N
authors.initials: N
authors.lastname: Rajendran
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D007700:Kinetics; D008422:Materials Testing; D043942:Nanotubes / Q000145:classification*; D011794:Quercetin / Q000737:chemistry*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; C009495:titanium dioxide; D048271:Chitosan; D011794:Quercetin; D014025:Titanium
keywords: Chitosan; Nanotubes drug release; Quercetin