title: Preparation of 5-Aryl-2-Alkyltetrazoles with Aromatic Aldehydes, Alkylhydrazine, Di-tert-butyl Azodicarboxylate, and [Bis(trifluoroacetoxy)iodo]benzene.
abstract: A variety of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles were directly prepared in good to moderate yields by the reaction of aromatic aldehydes with methylhydrazine and benzylhydrazine, followed by treatment with di-tert-butyl azodicarboxylate and [bis(trifluoroacetoxy)iodo]benzene in a mixture of dichloromethane and 2,2,2-trifluoroethanol at room temperature. The present method is a novel one-pot preparation of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles through a [2N + 2N] combination under transition metal-free and mild conditions.
authors.affiliation: Graduate School of Science, Chiba University , Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Imai
authors.affiliation: Graduate School of Science, Chiba University , Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Harigae
authors.affiliation: Graduate School of Science, Chiba University , Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.|Molecular Chirality Research Center, Chiba University , Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Moriyama
authors.affiliation: Graduate School of Science, Chiba University , Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Togo