title: Specific gene expression patterns of 108 schizophrenia-associated loci in cortex.
abstract: The latest genome-wide association study of schizophrenia identified 108 distinct genomic loci that contribute to schizophrenia. Brain development and function depend on the precise regulation of gene expression. The expression of many genes is differentially regulated across brain regions and developmental time points. We investigated the specific gene expression patterns arising from the 108 schizophrenia-associated loci using multiple publicly available databases and multiple regional brain datasets from developing and adult post-mortem human brains. The temporal-spatial expression analysis revealed that the genes in these loci were intensively enriched in the cortex during several developmental stages. These cortex-specific genes were particularly expressed in the fetal brain and adult neocortex.
authors.affiliation: Department of Neuropsychiatry, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan. Electronic address: ohi@kanazawa-med.ac.jp.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohi
authors.affiliation: Department of Neuropsychiatry, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Shimada
authors.affiliation: Department of Neuropsychiatry, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nitta
authors.affiliation: Department of Neuropsychiatry, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kihara
authors.affiliation: Department of Neuropsychiatry, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okubo
authors.affiliation: Department of Neuropsychiatry, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Uehara
authors.affiliation: Department of Neuropsychiatry, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawasaki
mesh_terms: D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D056426:Genetic Loci; D006801:Humans; D064326:MEF2 Transcription Factors / Q000378:metabolism; D036961:Matrix Attachment Region Binding Proteins / Q000378:metabolism; D046228:Microarray Analysis; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism*; D051669:Shab Potassium Channels / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D064326:MEF2 Transcription Factors; D036961:Matrix Attachment Region Binding Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D051669:Shab Potassium Channels; D014157:Transcription Factors; C496988:KCNB1 protein, human; C578040:MEF2C protein, human; C521297:SATB2 protein, human
keywords: GRIN2A; KCNB1; MEF2C; SATB2; Schizophrenia; Temporal-spatial expression