title: Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography.
abstract: OBJECTIVE
  To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group).
  
  
  RESULTS
  The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch's disruption in 100%, and pigment epithelial detachment (PED) in 75% of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis.
  
  
  CONCLUSIONS
  SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.
authors.affiliation: a Department of Ophthalmology and Visual Sciences , Kentucky Lions Eye Center, University of Louisville School of Medicine , Louisville , Kentucky , USA.
authors.forename: Mehreen
authors.initials: M
authors.lastname: Adhi
authors.affiliation: a Department of Ophthalmology and Visual Sciences , Kentucky Lions Eye Center, University of Louisville School of Medicine , Louisville , Kentucky , USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Jusufbegovic
authors.affiliation: a Department of Ophthalmology and Visual Sciences , Kentucky Lions Eye Center, University of Louisville School of Medicine , Louisville , Kentucky , USA.
authors.forename: Shlomit
authors.initials: S
authors.lastname: Schaal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D015821:Eye Infections, Fungal / Q000175:diagnosis*; D005260:Female; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods; D055815:Young Adult
keywords: Choroidal neovascular membrane; histo spots; pigment epithelial detachment; presumed ocular histoplasmosis syndrome; spectral-domain optical coherence tomography