title: Correlation of serum ANA and direct immunofluorescence studies in elderly Thai patients with red and white oral lesions.
abstract: OBJECTIVE
  This study investigated the presence of serum antinuclear antibodies (ANA) profile and direct immunofluorescence (DIF) evaluation in elderly Thai patients with red and white oral lesions.
  
  
  METHODS
  Thirty-two patients with red and white oral lesions were divided into two groups: group I consisted of 10 cases not taking medications, while group II consisted of 12 cases taking medications, and 30 healthy subjects as a control group. Blood samples were used to determine the ANA profile. DIF was investigated in the lesion containing groups.
  
  
  RESULTS
  Serum ANA was found in six cases (60%) in group I, eight cases (66.7%) in group II, and 19 cases (63.3%) in the control group. There were no significant differences between group I and group II and the control group (P > 0.05). Serum ANA was most commonly found in patients taking hypolipidemics (80%), followed by antihypertensives (71.4%), NSAIDs (50%), hypoglycemics (50%), and others (66.7%). The anticytoplasmic staining frequency in group II was higher compared with group I and the control group. Anti-dsDNA antibodies were not found in any group.
  
  
  CONCLUSIONS
  Elderly patients with red and white oral lesions who were taking medications had a higher serum ANA frequency than group I and the control group.
authors.affiliation: Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. kobkan.t@chula.ac.th.
authors.forename: Kobkan
authors.initials: K
authors.lastname: Thongprasom
authors.affiliation: Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Chanwit
authors.initials: C
authors.lastname: Prapinjumrune
authors.affiliation: Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Patnarin
authors.initials: P
authors.lastname: Kanjanabuch
authors.affiliation: Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Pornpan
authors.initials: P
authors.lastname: Youngnak-Piboonratanakit
authors.affiliation: Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Titipong
authors.initials: T
authors.lastname: Preuksrisakul
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct / Q000379:methods*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D013785:Thailand
chemical_list: D000890:Anti-Infective Agents; D000974:Antibodies, Antinuclear; D000960:Hypolipidemic Agents
keywords: antinuclear antibodies; elderly; lichen planus; lupus erythematosus; medications