title: Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.
abstract: A useful design element in small molecule libraries is spatial diversity, in which binding moieties are systematically directed toward different regions of three-dimensional space. One way of achieving this is through the use of conformationally diverse scaffolds onto which various binding moieties can be placed. Such scaffolds can represent synthetic challenges of their own. In this paper, we describe a new route to chiral, cyclic 1,3-diol building blocks that features silylated dithianes as relay linchpins. These diols are subsequently used for the construction of a 24-compound pilot library bearing two amino acid residues.
authors.affiliation: The University of Kansas Chemical Methodologies and Library Development Center, 2034 Becker Drive, Del Shankel Structural Biology Center, Lawrence, Kansas 66047, United States. jaube@unc.edu.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Singh
authors.affiliation: The University of Kansas Chemical Methodologies and Library Development Center, 2034 Becker Drive, Del Shankel Structural Biology Center, Lawrence, Kansas 66047, United States. jaube@unc.edu.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Aubé