title: Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.
abstract: Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.
authors.affiliation: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Ki Jun
authors.initials: KJ
authors.lastname: Yu
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.|Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, CA 92093.
authors.forename: Duygu
authors.initials: D
authors.lastname: Kuzum
authors.affiliation: KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Suk-Won
authors.initials: SW
authors.lastname: Hwang
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Bong Hoon
authors.initials: BH
authors.lastname: Kim
authors.affiliation: Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Halvor
authors.initials: H
authors.lastname: Juul
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Nam Heon
authors.initials: NH
authors.lastname: Kim
authors.affiliation: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Won
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Chiang
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Trumpis
authors.affiliation: Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Richardson
authors.affiliation: Department of Engineering Science and Mechanics, Penn State University, University Park, PA 16802, USA.
authors.forename: Huanyu
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.|Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Chemical and Biomolecular Engineering University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Marissa
authors.initials: M
authors.lastname: Thomson
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.|Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Hank
authors.initials: H
authors.lastname: Bink
authors.affiliation: Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Delia
authors.initials: D
authors.lastname: Talos
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Seo
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana- Champaign, Urbana, IL 61801, USA.
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Lee
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Seung-Kyun
authors.initials: SK
authors.lastname: Kang
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana- Champaign, Urbana, IL 61801, USA.
authors.forename: Jung Yup
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Mechanical Engineering and Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Younggang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Frances E
authors.initials: FE
authors.lastname: Jensen
authors.affiliation: Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Dichter
authors.affiliation: Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Lucas
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Viventi
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.|Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Litt
authors.affiliation: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.|Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Rogers
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D058256:Brain Waves / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D051381:Rats; D012825:Silicon / Q000737:chemistry / Q000494:pharmacology
chemical_list: D012825:Silicon