title: Fluorescence and Cerenkov luminescence imaging. Applications in small animal research.
abstract: This review addresses small animal optical imaging (OI) applications in diverse fields of basic research. In the past, OI has proven to be cost- and time-effective, allows real-time imaging as well as high-throughput analysis and does not imply the usage of ionizing radiation (with the exception of Cerenkov imaging applications). Therefore, this technique is widely spread - not only geographically, but also among very different fields of basic research - and is represented by a large body of publications. Originally used in oncology research, OI is nowadays emerging in further areas like inflammation and infectious disease as well as neurology. Besides fluorescent probe-based contrast, the feasibility of Cerenkov luminescence imaging (CLI) has been recently shown in small animals and thus represents a new route for future applications. Thus, this review will focus on examples for OI applications in inflammation, infectious disease, cell tracking as well as neurology, and provides an overview over CLI.
authors.forename: J
authors.initials: J
authors.lastname: Schwenck
authors.forename: K
authors.initials: K
authors.lastname: Fuchs
authors.forename: S H L
authors.initials: SH
authors.lastname: Eilenberger
authors.forename: A-M
authors.initials: AM
authors.lastname: Rolle
authors.forename: S
authors.initials: S
authors.lastname: Castaneda Vega
authors.forename: W M
authors.initials: WM
authors.lastname: Thaiss
authors.affiliation: Florian C. Maier, Dr. rer nat, Röntgenweg 13, 72076 Tübingen, Tel. +49/(0)70 71/298 74 87, Fax +49/(0)70 71/29 44 51, florian.maier@med.uni-tuebingen.de.
authors.forename: F C
authors.initials: FC
authors.lastname: Maier
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D005456:Fluorescent Dyes / Q000737:chemistry*; D008163:Luminescent Measurements / Q000662:veterinary*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000662:veterinary*; D057054:Molecular Imaging / Q000662:veterinary*; D051381:Rats; D051598:Whole Body Imaging / Q000662:veterinary*
chemical_list: D005456:Fluorescent Dyes
keywords: Cerenkov luminescence; Optical imaging; fluorescence; small animal