title: Acellular Dermal Matrix Combined with Autologous Skin Grafts for Closure of Chronic Wounds after Reconstruction of Skull Defects with Titanium Mesh.
abstract: Objective The closure of chronic wounds after skull defect reconstruction with titanium mesh is one of the most challenging problems for plastic and reconstructive surgeons. Current approaches are disappointing. Methods In 10 patients, we explored the role of acellular dermal matrix (ADM) in combination with autologous skin grafts (ASGs) for closure of chronic wounds after skull reconstruction with titanium. Results ADM and ASG survived in all patients. Grade A healing (healing well without defect) was achieved. The average operating time was 30 to 45 minutes, and the average blood loss 30 to 50 mL. After 3 months, the wound was still closed in all patients. Conclusion The combination of ADM plus ASG obtained a high wound closure rate. ADM plus ASG allows avoiding other procedures such as rotational flaps and free flaps that require more operating time, special equipment, and adequate training.
authors.affiliation: Department of Wounds and Burns Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Burn, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China.
authors.forename: Cai
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Outpatient Services Center, The Taihe Hospital of Hubei Medical College, Shiyan, HuBei Province, China.
authors.forename: Xinling
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Wounds and Burns Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Clinical Medical Sciences, The School of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Sunyue
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Wounds and Burns Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Wounds and Burns Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Wounds and Burns Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Ruijin
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Suzhou Medical College, Suzhou Province, China.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Zhu
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods*; D012886:Skull / Q000601:surgery*; D013524:Surgical Flaps; D013526:Surgical Mesh; D000072836:Surgical Wound / Q000601:surgery*; D014025:Titanium; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
chemical_list: D014025:Titanium