title: Analgesic drugs and the gut - a reciprocal relationship.
abstract: Analgesic drugs, as well as providing pain relief, can cause a range of other symptoms and side effects, most notably on the gastrointestinal system. Conversely, gastrointestinal disease will often require analgesia, and this can be complicated by the fact that the gut is the site of absorption of oral drugs. This paper discusses some of the effects of common oral analgesic drugs on the gastrointestinal tract and their role in managing some of the most common, nonmalignant, chronic gastrointestinal disorders in adults.
authors.affiliation: R Lawrence, Royal Edinburgh Hospital, Morningside Terrace, Edinburgh EH10 5HF, UK. Email rebecca.lawrence@nhslothian.scot.nhs.uk.
authors.forename: R
authors.initials: R
authors.lastname: Lawrence
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects; D000284:Administration, Oral; D000588:Amines / Q000008:administration & dosage / Q000009:adverse effects; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D059350:Chronic Pain / Q000188:drug therapy*; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage / Q000009:adverse effects; D004066:Digestive System Diseases / Q000139:chemically induced* / Q000150:complications*; D000077206:Gabapentin; D006801:Humans; D000069583:Pregabalin / Q000008:administration & dosage / Q000009:adverse effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000082:Acetaminophen; D000588:Amines; D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003509:Cyclohexanecarboxylic Acids; D000077206:Gabapentin; D000069583:Pregabalin; D017367:Selective Serotonin Reuptake Inhibitors; D005680:gamma-Aminobutyric Acid
keywords: analgesics; chronic pain; gastrointestinal tract,; opioid-induced bowel dysfunction