title: Vitamin D deficiency related to physical capacity during cardiac rehabilitation.
abstract: BACKGROUND
  Vitamin D deficiency is a frequent pathology associated with cardiovascular diseases and physical performance.
  
  
  OBJECTIVE
  To study the link between 25-hydroxyvitamin D (25OHD) level and physical performance and gain in physical performance after cardiovascular rehabilitation (CVR) with vitamin D deficiency.
  
  
  METHODS
  25OHD level was assessed in a retrospective cohort of patients admitted for CVR. Data were collected on physical fitness [6-min walk test distance (6MWD) in percentage of predicted, maximal power (Pmax)]. The threshold of vitamin D deficiency was 20ng/ml chosen according to the literature.
  
  
  RESULTS
  Among the 131 patients included, as compared with those with nondeficiency (n=83; 63%), patients with vitamin D deficiency (n=48, 37%) had lower initial 6MWD (82±18 vs 89±12% predicted, P=0.009) and Pmax (100±58 vs 120±39W, P=0.006). After CVR, this difference was maintained. The improvement in 6MWD and Pmax was significantly lower with deficiency than nondeficiency, for an increase of 11±8% versus 14±9% predicted (P=0.048) and 10±30 versus 32±30W (P=0.00001), respectively.
  
  
  CONCLUSIONS
  Vitamin D deficiency may be associated with impaired physical fitness before CVR and a smaller gain in physical fitness with CVR, probably related to the action of vitamin D on the muscle.
authors.affiliation: Unité de réadaptation cardiaque ambulatoire, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex, France; Unité d'hypertension, d'insuffisance cardiaque et facteur de risque, clinique Pasteur, 45, avenue de Lombez, 31300 Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Ucay
authors.affiliation: Unité de réadaptation cardiaque ambulatoire, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex, France; Unité d'hypertension, d'insuffisance cardiaque et facteur de risque, clinique Pasteur, 45, avenue de Lombez, 31300 Toulouse, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Pouche
authors.affiliation: Équipe 8, I2MC, Inserm UMR-1048, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, BP 84225, 31432 Toulouse cedex 4, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Guiraud
authors.affiliation: Équipe 8, I2MC, Inserm UMR-1048, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, BP 84225, 31432 Toulouse cedex 4, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Besnier
authors.affiliation: Équipe 8, I2MC, Inserm UMR-1048, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, BP 84225, 31432 Toulouse cedex 4, France; Unité d'hypertension, d'insuffisance cardiaque et facteur de risque, clinique Pasteur, 45, avenue de Lombez, 31300 Toulouse, France.
authors.forename: Atul
authors.initials: A
authors.lastname: Pathak
authors.affiliation: Unité de réadaptation cardiaque ambulatoire, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex, France; Équipe 8, I2MC, Inserm UMR-1048, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, BP 84225, 31432 Toulouse cedex 4, France; Unité d'hypertension, d'insuffisance cardiaque et facteur de risque, clinique Pasteur, 45, avenue de Lombez, 31300 Toulouse, France. Electronic address: labrunee.m@chu-toulouse.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Labrunee
mesh_terms: D000328:Adult; D000368:Aged; D000072038:Cardiac Rehabilitation; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness / Q000502:physiology*; D012189:Retrospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000503:physiopathology*; D000070857:Walk Test; D016138:Walking / Q000502:physiology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 6-min walking test; Cardiovascular rehabilitation; Maximal power; Vitamin D deficiency