title: Comparing effects of different routes of heparin administration on the serum biomarkers of thrombosis.
abstract: Association between thrombosis pathogenesis and inflammatory conditions has been reported. Also inflammatory biomarkers have been proposed for prediction of thrombosis events.
  
  
  
  Effects of different methods of heparin administration (subcutaneous vs continuous infusion) as thromboprophylaxis on the biomarkers of thrombosis have been evaluated.
  
  
  
  Serum levels of hsCRP, IL-10 and P-selectin as the biomarkers of thrombosis were measured at baseline, days 3 and 7 during the patients' hospitalization period.
  
  
  
  Changes in the serum levels of thrombosis biomarkers (hsCRP, IL-10 and P-selectin) were comparable between the subcutaneous and continuous infusion groups.
  
  
  
  Both subcutaneous injection and continuous infusion of heparin as thromboprophylaxis showed same effects on the thrombosis biomarkers.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran.
authors.forename: Mandana
authors.initials: M
authors.lastname: Izadpanah
authors.affiliation: Department of Anesthesiology & Critical Care Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Mohammadi
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Khalili
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy & Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faramarzi
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D015415:Biomarkers; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D016753:Interleukin-10; D019007:P-Selectin; D013927:Thrombosis / Q000097:blood*
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D019007:P-Selectin; D016753:Interleukin-10; D006493:Heparin
keywords: IL-10; P-selectin; heparin; high-sensitive C-reactive protein