title: Hematobiochemical alterations of acute chlorpyriphos intoxication in indigenous chicken.
abstract: OBJECTIVE
  The present investigation was undertaken to elaborate hematobiochemical alterations of acute chlorpyriphos (CPF) toxicity in indigenous chicken. Since there is no available literature on the detailed hematobiochemical changes of CPF in indigenous chicken, hence, the present study was designed to establish toxicological effect of CPF on blood biochemical parameters of indigenous chicken which are at a great risk of exposure to pesticides. These will help physiologist, pathologist, and poultry scientists for effective production strategy as well as disease control regime.
  
  
  METHODS
  The birds were divided into two major Groups I and II. Group I served as control and Group II was treated with CPF (36 mg/kg). Blood samples were assayed for hemoglobin (Hb), total erythrocyte count (TEC), total leukocyte count (TLC), differential leukocyte count, and biochemical constituents such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (CHE), total protein, and uric acid.
  
  
  RESULTS
  Hb, TEC, and TLC levels increased significantly (p<0.01) in toxin fed birds, whereas, lymphocyte percent decreased significantly, and heterophil percent increased significantly. Serum ALP, AST, ALT, and uric acid increased significantly in CPF treated birds. Decreased serum CHE values were observed in CPF fed group. The protein level remained almost same. Uric acid level was found to be increased significantly in the treated group compared to control.
  
  
  CONCLUSIONS
  The results indicated that acute CPF intoxication produce changes in hematology and biochemical constituents of the treated birds.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India.
authors.forename: Shameem Ara
authors.initials: SA
authors.lastname: Begum
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India.
authors.forename: Tirtha Nath
authors.initials: TN
authors.lastname: Upadhyaya
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India.
authors.forename: Gautam Kumar
authors.initials: GK
authors.lastname: Baruah
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India.
authors.forename: Taibur
authors.initials: T
authors.lastname: Rahman
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India.
authors.forename: Debesh Chandra
authors.initials: DC
authors.lastname: Pathak
authors.affiliation: Department of Anatomy and Histology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India.
authors.forename: Kabita
authors.initials: K
authors.lastname: Sarma
authors.affiliation: Department of Livestock Production and Management, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India.
authors.forename: Rumi Saikia
authors.initials: RS
authors.lastname: Bora
keywords: acute toxicity; biochemical; chlorpyriphos; hematology