title: [Ultrastructural changes of lymphocytes in patients with schizophrenia treated with olanzapine].
abstract: OBJECTIVE
  to study the effect of olanzapine on the ultrastructure of different populations of lymphocytes and lymphoblasts in patients with schizophrenia.
  
  
  METHODS
  Authors performed a morphometric study using electron microscopy of lymphocytes in 56 patients with schizophrenia treated for 8 weeks with olanzapine and 49 patients treated for 28 weeks with olanzapine before and after treatment. Authors estimated the frequency and ultrastructural parameters of small, large, large activated lymphocytes and lymphoblasts.
  
  
  RESULTS
  The frequency of small lymphocytes in patients treated with olanzapine increased and that of large lymphocytes decreased in treated patients as compared to the patients before treatment. The volume fraction of lysosomes increased significantly in small, large and large activated lymphocytes after treatment as compared to the patients before treatment.
  
  
  CONCLUSIONS
  The increased lysosome content in different lymphocyte subpopulations might contribute to the mechanism of olanzapine efficacy.
authors.affiliation: Mental Health Research Center of RAS, Moscow.
authors.forename: P D
authors.initials: PD
authors.lastname: Bonartsev
authors.affiliation: Mental Health Research Center of RAS, Moscow.
authors.forename: V I
authors.initials: VI
authors.lastname: Rakhmanova
authors.affiliation: Mental Health Research Center of RAS, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Uranova
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008854:Microscopy, Electron; D000077152:Olanzapine / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine