title: [Results of surgical and combined treatment of non-small cell lung cancer].
abstract: OBJECTIVE
  To study the results of surgical and combined treatment of non-small cell lung cancer stage III using preoperative chemotherapy and intraoperative radiotherapy.
  
  
  METHODS
  The study included 152 patients with non-small cell lung cancer stage III. Overall and recurrence-free 5-year survival were 20.4% and 14.3% respectively. These values were significantly higher in case of combined treatment consisting of radical surgery and intraoperative radiotherapy (29.2% and 18.7% respectively, p<0.05).
  
  
  RESULTS
  The best results were obtained in case of preoperative chemotherapy with paclitaxel/carboplatin, radical surgery and intraoperative radiotherapy on background of radiosensitization with cisplatin. Overall and recurrence-free 5-year survival were 47.9% and 41.7% respectively (p<0.05). Incidence of postoperative complications and mortality rate did not significantly differ between surgical and combined treatment (p>0.05).
authors.affiliation: Tomsk Research Oncology Institute.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Dobrodeev
authors.affiliation: Tomsk Research Oncology Institute; Siberian State Medical University, Health Ministry of the Russian Federation, Tomsk.
authors.forename: A A
authors.initials: AA
authors.lastname: Zav'yalov
authors.affiliation: Tomsk Research Oncology Institute; Siberian State Medical University, Health Ministry of the Russian Federation, Tomsk.
authors.forename: S A
authors.initials: SA
authors.lastname: Tuzikov
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D016190:Carboplatin / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage*; D011013:Pneumonectomy / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin