title: Pseudotumour Cerebri Presentation in a Child Under the Gonadotropin-Releasing Hormone Agonist Treatment.
abstract: Gonadotropin-releasing hormone analogues are common treatment option in central precocious puberty in childhood as well as in endometriosis, infertility, and prostate cancer in adults. Pseudotumor cerebri is a rare side effect observed in adults. We present the case of a girl with precocious puberty treated with triptorelin acetate who developed pseudotumor cerebri after the 4th dose. She had headaches, and her blood pressure was detected to be above the 99 percentile. There were no causes underlying of hypertension such as cardiac, renal, or endocrine. Neurological examination was normal except bilateral papilledema. Cranial magnetic resonance imaging was normal. Cerebrospinal fluid (CSF) opening pressure was elevated. Triptorelin therapy was ceased and acetazolamide was applied; CSF pressure returned to normal. We observed pseudotumor cerebri after precocious puberty treatment, a finding for the first time ever seen in childhood.
authors.affiliation: Erciyes University Faculty of Medicine, Department of Pediatric Endocrinology, Kayseri, Turkey, Phone: +90 352 437 49 31 E-mail: dr.ulku.81@hotmail.com.
authors.forename: Ülkü
authors.initials: Ü
authors.lastname: Gül
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kaçar Bayram
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kendirci
authors.forename: Nihal
authors.initials: N
authors.lastname: Hatipoğlu
authors.forename: Deniz
authors.initials: D
authors.lastname: Okdemir
authors.forename: Hakan
authors.initials: H
authors.lastname: Gümüş
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
mesh_terms: D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008186:Luteolytic Agents / Q000009:adverse effects; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D011629:Puberty, Precocious / Q000188:drug therapy*; D017329:Triptorelin Pamoate / Q000009:adverse effects*
chemical_list: D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone