title: sCD95L in serum after spinal cord injury.
abstract: METHODS
  A prospective observational study reporting correlation between sCD95L (serum cluster of differentiation 95 ligand) serum levels and remission after traumatic spinal cord injury (SCI).
  
  
  OBJECTIVE
  To describe the correlation between sCD95L serum levels and remission after traumatic SCI in a human protocol compared with animal studies.
  
  
  METHODS
  Rhineland-Palatinate (Rheinland-Pfalz), Germany.
  
  
  METHODS
  We included 45 patients with traumatic SCI. According to their neurological outcome, patients were divided into two groups, patients with (G1, n=26) and without (G2, n=19) remission. Blood was collected on post-admission and according to a fixed scheme, that is, after 4, 9, 12 h, 1, 3 days and 1, 2, 4, 8, 12 weeks.
  
  
  RESULTS
  By comparing G1 with G2, we found a correlation between neurological remission and sCD95L serum concentrations. Consistently elevated levels of sCD95L in G1 between 9 h and 1 month after injury show significantly differing values 7 days after injury. This indicates a correlation between patients with clinically documented neurological remission and elevated sCD95L serum concentrations.
  
  
  CONCLUSIONS
  In opposite to animal studies, our patients with neurological remission show on average higher levels of sCD95L compared with patients without. Therefore, spinal cord-injured patients would probably not profit from neutralizing CD95L. Our results present that the transfer of findings from animal studies to humans must always be considered critically. We were able to show that peripheral serum cytokine expression is suitable to state processes after SCI in humans.
authors.affiliation: Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, HTRG-Heidelberg Trauma Research Group, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Moghaddam
authors.affiliation: Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, HTRG-Heidelberg Trauma Research Group, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Sperl
authors.affiliation: Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, HTRG-Heidelberg Trauma Research Group, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Heller
authors.affiliation: Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, HTRG-Heidelberg Trauma Research Group, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Gerner
authors.affiliation: Department of Paraplegiology, Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Ludwigshafen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Biglari
mesh_terms: D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood; D053222:Fas Ligand Protein / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000097:blood*; D013997:Time Factors
chemical_list: D016207:Cytokines; D053222:Fas Ligand Protein