title: Lipid profiles of children and adolescents with inflammatory response in a paediatric emergency department.
abstract: To compare the lipid profile between patients with and without inflammatory process in according nutritional status, gender and age.
  
  
  
  One hundred and twenty-four children and adolescents in the emergency department were separated into two groups according to the levels of C-reactive protein (CRP). Total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL), triglycerides (TG) and albumin in patients with CRP < 5 mg/L were compared with patients with CRP ≥ 5 mg/L. Nutritional status was assessed by anthropometric measurements.
  
  
  
  Patients were mostly classified as well-nourished (76.5%) and had low levels of HDL (70%). There was no significant difference in lipid profile between the two groups of CRP. Linear regression analysis, however, it became clear that for each increase of 1 mg/L in the values of CRP expected an average reduction of 0.072 mg/dL of HDL, the 0.083 mg/dL of LDL, the 0.002 g/dL albumin and an average increase of 0.564 mg/dL of TG.
  
  
  
  Patients with an inflammatory process exhibit changes in the serum levels of the lipids HDL, LDL and TG that are related to the degree of inflammation. These changes occurred regardless of nutritional status. Key Messages Lipoproteins are structures composed of lipids and proteins that transport fats in the circulation: HDL, LDL, IDL, VLDL and chylomicrons. Lipoproteins, especially HDL, undergo changes during the systemic inflammatory response and play an important role as a modulator of the inflammatory response. We believe this is a first study to show that inflammatory process modifies the serum levels of the lipoproteins and triglycerides independent of nutritional status, in paediatric patients.
authors.affiliation: a Pediatric Department , São Paulo University Medical School , São Paulo , Brazil ;
authors.forename: Giovana
authors.initials: G
authors.lastname: Muramoto
authors.affiliation: a Pediatric Department , São Paulo University Medical School , São Paulo , Brazil ;
authors.forename: Artur
authors.initials: A
authors.lastname: Figueiredo Delgado
authors.affiliation: a Pediatric Department , São Paulo University Medical School , São Paulo , Brazil ;
authors.forename: Eloisa
authors.initials: E
authors.lastname: Correa de Souza
authors.affiliation: a Pediatric Department , São Paulo University Medical School , São Paulo , Brazil ;
authors.forename: Alfredo
authors.initials: A
authors.lastname: Elias Gilio
authors.affiliation: a Pediatric Department , São Paulo University Medical School , São Paulo , Brazil ;
authors.forename: Werter
authors.initials: W
authors.lastname: Brunow de Carvalho
authors.affiliation: b Lipid Metabolism Laboratory , Heart Institute, São Paulo University Medical School , São Paulo , Brazil.
authors.forename: Raul
authors.initials: R
authors.lastname: Cavalcante Maranhão
mesh_terms: D000293:Adolescent; D001837:Body Weights and Measures; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004636:Emergency Service, Hospital; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008297:Male; D009752:Nutritional Status
chemical_list: D008055:Lipids; D002097:C-Reactive Protein
keywords: C-reactive protein; HDL; Lipoproteins; child; cholesterol; infections; lipids; lipoproteins; triglycerides