title: [The Role of c-fos in the Production of Follicle-Stimulating Hormone and the Related Signal Transduction Pathways].
abstract: As an immediate early gene, c-fos plays a critical role in stimulating the synthesis and release of pituitary FSH via GnRH. To better understanding the mechanism how c-fos works in the transcription of FSHbeta under different frequency of pulsatile GnRH stimulation, this paper reviewed the signal trans- ductions initiated by c-fos in pituitary, which include cAMP pathway, MAPK pathway, Ca2+ /calmodulin-dependent kinases pathway and nuclear factor of activated T-cells (NFAT) pathway. It will be helpful for research in molecular targeted immunotherapy and eventually effective treatment to the infertility which resulted from defection or mutation of c-fos and c-fos related signal pathway elements.
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Chen
authors.forename: Jun-Qin
authors.initials: JQ
authors.lastname: Huang
authors.forename: Xue-Jie
authors.initials: XJ
authors.lastname: Yi
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: Zhang
mesh_terms: D005640:Follicle Stimulating Hormone; D016762:Genes, fos; D015398:Signal Transduction
chemical_list: D005640:Follicle Stimulating Hormone