title: Oral Vaccine Development by Molecular Display Methods Using Microbial Cells.
abstract: Oral vaccines are easier to administer than injectable vaccines. To induce an adequate immune response using vaccines, antigenic proteins are usually combined with adjuvant materials. This chapter presents methodologies for the design of oral vaccines using molecular display technology. In molecular display technology, antigenic proteins are displayed on a microbial cell surface with adjuvant ability. This technology would provide a quite convenient process to produce oral vaccines when the DNA sequence of an efficient antigenic protein is available. As an example, oral vaccines against candidiasis were introduced using two different molecular display systems with Saccharomyces cerevisiae and Lactobacillus casei.
authors.affiliation: General Education Center and Graduate School of Pharmacy, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe, 650-8530, Japan. seiji@huhs.ac.jp.
authors.forename: Seiji
authors.initials: S
authors.lastname: Shibasaki
authors.affiliation: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Ueda
mesh_terms: D000276:Adjuvants, Immunologic / Q000235:genetics; D000284:Administration, Oral; D002176:Candida albicans / Q000276:immunology; D004926:Escherichia coli / Q000235:genetics; D005818:Genetic Engineering / Q000379:methods*; D007780:Lacticaseibacillus casei / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014612:Vaccines / Q000008:administration & dosage / Q000235:genetics* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D014612:Vaccines
keywords: Candida albicans; Candidiasis; Cell surface; Lactobacillus casei; Molecular display; Oral vaccine; Saccharomyces cerevisiae