title: TRP functions in the broncho-pulmonary system.
abstract: The current understanding of the role of transient receptor potential (TRP) channels in the airways and lung was initially based on the localization of a series of such channels in a subset of sensory nerve fibers of the respiratory tract. Soon after, TRP channel expression and function have been identified in respiratory nonneuronal cells. In these two locations, TRPs regulate physiological processes aimed at integrating different stimuli to maintain homeostasis and to react to harmful agents and tissue injury by building up inflammatory responses and repair processes. There is no doubt that TRPs localized in the sensory network contribute to airway neurogenic inflammation, and emerging evidence underlines the role of nonneuronal TRPs in orchestrating inflammation and repair in the respiratory tract. However, recent basic and clinical studies have offered clues regarding the contribution of neuronal and nonneuronal TRPs in the mechanism of asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cough, and other respiratory diseases.
authors.affiliation: Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Logu
authors.affiliation: Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.|Chiesi Farmaceutici S.p.A, Parma, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Patacchini
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fontana
authors.affiliation: Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy. pierangelo.geppetti@unifi.it.
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Geppetti
mesh_terms: D000818:Animals; D001249:Asthma / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D004198:Disease Susceptibility; D015870:Gene Expression; D006801:Humans; D005810:Multigene Family; D020033:Protein Isoforms; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D012143:Respiratory Physiological Phenomena / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D012137:Respiratory System / Q000187:drug effects / Q000276:immunology* / Q000294:innervation / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D050051:Transient Receptor Potential Channels
keywords: Neurogenic inflammation; Oxidative stress; TRPA1; TRPV1