title: Flavonoids in Inflammatory Bowel Disease: A Review.
abstract: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients' life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavonoids. Flavonoids are compounds with low molecular weight that are widely distributed throughout the vegetable kingdom, including in edible plants. They may be of great utility in conditions of acute or chronic intestinal inflammation through different mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties in the gut. In this review we have revised the main flavonoid classes that have been assessed in different experimental models of colitis as well as the proposed mechanisms that support their beneficial effects.
authors.affiliation: CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain. teresavezza@hotmail.it.
authors.forename: Teresa
authors.initials: T
authors.lastname: Vezza
authors.affiliation: CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain. albarn@correo.ugr.es.
authors.forename: Alba
authors.initials: A
authors.lastname: Rodríguez-Nogales
authors.affiliation: CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain. fra.algieri@hotmail.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Algieri
authors.affiliation: CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain. utrillam@ugr.es.
authors.forename: Maria Pilar
authors.initials: MP
authors.lastname: Utrilla
authors.affiliation: CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain. merodri@ugr.es.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Rodriguez-Cabezas
authors.affiliation: CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain. jgalvez@ugr.es.
authors.forename: Julio
authors.initials: J
authors.lastname: Galvez
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005504:Food Analysis; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D015394:Molecular Structure
chemical_list: D000975:Antioxidants; D005419:Flavonoids
keywords: barrier function; eicosanoids; flavonoids; immunomodulatory properties; inflammatory bowel disease; oxidative stress