title: Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns.
abstract: OBJECTIVE
  Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-α) levels improve weight gain prediction during the first three months of life.
  
  
  METHODS
  Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-α were measured by multiplex immunoassay in a subsample of 86 healthy term newborns.
  
  
  RESULTS
  Leptin levels significantly predicted weight gain at 3 months of follow-up (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life.
  
  
  CONCLUSIONS
  Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-α to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Treviño-Garza
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Estrada-Zúñiga
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mancillas-Adame
authors.forename: Laura
authors.initials: L
authors.lastname: Villarreal-Martínez
authors.forename: Jesús Z
authors.initials: JZ
authors.lastname: Villarreal-Pérez
authors.forename: Isaías
authors.initials: I
authors.lastname: Rodríguez-Balderrama
authors.forename: Fernando F
authors.initials: FF
authors.lastname: Montes-Tapia
authors.affiliation: Cavazos MD, University Autonomous of Nuevo Leon, 'Dr. José E. González' University Hospital, Department of Pediatrics, Monterrey/Nuevo Leon, Mexico Phone: +52 (81) 83469959 E-mail: delaocavazos@yahoo.com.
authors.forename: Manuel E
authors.initials: ME
authors.lastname: de la O Cavazos
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism; D001724:Birth Weight; D018932:Chemokine CCL2 / Q000097:blood; D005312:Fetal Blood / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood*; D015999:Multivariate Analysis; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011237:Predictive Value of Tests; D052243:Resistin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015430:Weight Gain
chemical_list: D054392:Adipokines; D052242:Adiponectin; D018932:Chemokine CCL2; D015850:Interleukin-6; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha