title: Transfusion reactions: prevention, diagnosis, and treatment.
abstract: Blood transfusion is one of the most common procedures in patients in hospital so it is imperative that clinicians are knowledgeable about appropriate blood product administration, as well as the signs, symptoms, and management of transfusion reactions. In this Review, we, an international panel, provide a synopsis of the pathophysiology, treatment, and management of each diagnostic category of transfusion reaction using evidence-based recommendations whenever available.
authors.affiliation: Bloodworks NW, Seattle, WA, USA; University of Washington, Department of Laboratory Medicine, Seattle, WA, USA. Electronic address: meghand@bloodworksnw.org.
authors.forename: Meghan
authors.initials: M
authors.lastname: Delaney
authors.affiliation: Hospital Sirio Libanes Blood Bank, Sao Paulo, Brazil.
authors.forename: Silvano
authors.initials: S
authors.lastname: Wendel
authors.affiliation: BloodCenter of Wisconsin, Milwaukee, WI, USA.
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Bercovitz
authors.affiliation: Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital Clínic, UB, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Cid
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cohn
authors.affiliation: Department of Pathology and Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Dunbar
authors.affiliation: Laboratory of Clinical Biochemistry and Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.
authors.forename: Torunn O
authors.initials: TO
authors.lastname: Apelseth
authors.affiliation: Haemonetics Corporation, Braintree, MA, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Popovsky
authors.affiliation: NHS Blood and Transplant/Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UK; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Stanworth
authors.affiliation: Department of Medicine and Department of Laboratory Medicine & Pathology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Centre for Transfusion Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
authors.forename: Alan
authors.initials: A
authors.lastname: Tinmouth
authors.affiliation: Center for Clinical Transfusion Research, Sanquin, Netherlands.
authors.forename: Leo
authors.initials: L
authors.lastname: Van De Watering
authors.affiliation: Department of Anesthesiology & Bioengineering, University of Pittsburgh & McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Waters
authors.affiliation: Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh, Institute for Transfusion Medicine, Pittsburgh, PA, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Yazer
authors.affiliation: Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Ziman
mesh_terms: D001803:Blood Transfusion / Q000379:methods* / Q000592:standards; D019317:Evidence-Based Medicine; D006801:Humans; D065227:Transfusion Reaction / Q000175:diagnosis* / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy*