title: Use of intravenous propranolol for control of a large cervicofacial hemangioma in a critically ill neonate.
abstract: Cervicofacial segmental infantile hemangiomas (IH) may result in airway obstruction requiring use of propranolol to induce hemangioma regression and reestablish the airway. We present the first case using intravenous (IV) propranolol for control of airway obstruction and rapid expansion of cervicofacial IH in the setting of necrotizing enterocolitis (NEC) impaired gastrointestinal function. Intravenous dosing of propranolol was tolerated well in a critically ill neonate with multisystem complications of prematurity.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, PV01, Portland, OR 97239, USA; School of Medicine, Vanderbilt University, 201 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: Shanik.fernando@vanderbilt.edu.
authors.forename: Shanik J
authors.initials: SJ
authors.lastname: Fernando
authors.affiliation: Department of Dermatology, Oregon Health & Science University, Center for Health & Healing, Mail code: CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA.
authors.forename: Sabra
authors.initials: S
authors.lastname: Leitenberger
authors.affiliation: Department of Dermatology, Oregon Health & Science University, Center for Health & Healing, Mail code: CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA.
authors.forename: Matt
authors.initials: M
authors.lastname: Majerus
authors.affiliation: Department of Dermatology, Oregon Health & Science University, Center for Health & Healing, Mail code: CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA.
authors.forename: Alfons
authors.initials: A
authors.lastname: Krol
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, PV01, Portland, OR 97239, USA.
authors.forename: Carol J
authors.initials: CJ
authors.lastname: MacArthur
mesh_terms: D000402:Airway Obstruction / Q000209:etiology*; D016638:Critical Illness; D020345:Enterocolitis, Necrotizing / Q000150:complications; D005260:Female; D018324:Hemangioma, Capillary / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000209:etiology; D007275:Injections, Intravenous; D009062:Mouth Neoplasms / Q000150:complications / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*
chemical_list: D011433:Propranolol
keywords: Airway; Necrotizing enterocolitis; Propranolol; Segmental infantile hemangioma; Vascular anomaly