title: The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo.
abstract: Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.
authors.affiliation: Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Cabana
authors.affiliation: Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.
authors.forename: Maxime
authors.initials: M
authors.lastname: Bourgognon
authors.affiliation: Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.
authors.forename: Julie T-W
authors.initials: JT
authors.lastname: Wang
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.|Cardiovascular Division, James Black Centre, British Heart Foundation Centre of Excellence, King's College London, London, SE5 9NU, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Protti
authors.affiliation: Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Klippstein
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.
authors.forename: Rafael T M
authors.initials: RT
authors.lastname: de Rosales
authors.affiliation: Cardiovascular Division, James Black Centre, British Heart Foundation Centre of Excellence, King's College London, London, SE5 9NU, UK.
authors.forename: Ajay M
authors.initials: AM
authors.lastname: Shah
authors.affiliation: Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Fontcuberta
authors.affiliation: Escola Universitària de Ciències de la Salut de Manresa, Universitat de Vic-Universitat Central de Catalunya, Av. Universitària 4-6, 08242, Manresa, Barcelona, Spain.
authors.forename: Ester
authors.initials: E
authors.lastname: Tobías-Rossell
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1A 7BE, UK.
authors.forename: Jane K
authors.initials: JK
authors.lastname: Sosabowski
authors.affiliation: Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.
authors.forename: Khuloud T
authors.initials: KT
authors.lastname: Al-Jamal
authors.affiliation: Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Tobias
mesh_terms: D000818:Animals; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D037742:Nanotubes, Carbon
keywords: MRI; SPECT; carbon nanotubes; dual-imaging; shortening