title: Clathrin-mediated endocytosis in budding yeast at a glance.
abstract: Clathrin-mediated endocytosis is an essential cellular process that involves the concerted assembly and disassembly of many different proteins at the plasma membrane. In yeast, live-cell imaging has shown that the spatiotemporal dynamics of these proteins is highly stereotypical. Recent work has focused on determining how the timing and functions of endocytic proteins are regulated. In this Cell Science at a Glance article and accompanying poster, we review our current knowledge of the timeline of endocytic site maturation and discuss recent works focusing on how phosphorylation, ubiquitylation and lipids regulate various aspects of the process.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Lu
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA drubin@berkeley.edu.
authors.forename: David G
authors.initials: DG
authors.lastname: Drubin
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
authors.forename: Yidi
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D050356:Lipid Metabolism; D010766:Phosphorylation; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D004718:Saccharomycetales / Q000502:physiology*; D054875:Ubiquitination
chemical_list: D002966:Clathrin; D029701:Saccharomyces cerevisiae Proteins
keywords: Actin; Clathrin-mediated endocytosis; Phospholipids; Phosphorylation; Saccharomyces cerevisiae; Ubiquitylation