title: Effect of ABCB1 rs12720464 and rs1055302 polymorphisms in Chinese patients on the time course of action of rocuronium administered as a single dose.
abstract: OBJECTIVE
  To determine whether ABCB1 gene polymorphisms affect the time course of action of rocuronium in Chinese patients.
  
  
  METHODS
  This study included 105 unrelated Chinese patients undergoing general anesthesia with propofol, fentanyl, and rocuronium. Neuromuscular monitoring was performed with calibrated acceleromyography. Patients were allowed to recover spontaneously from the neuromuscular block. The time interval between the first maximum depression of the train of four (TOF) and spontaneous recovery TOF ratio of 0.25/0.7/0.8/0.9 was recorded. The Sequenom MassArray® single-nucleotide polymorphism (SNP) detection technology was used to detect the genotypes of the ABCB1 rs12720464, rs1055302. Demographic and non-genetic clinical data were also collected.
  
  
  RESULTS
  In the present study, the mean time to spontaneous recovery of TOF ratio 0.8/0.9 in ABCB1 rs12720464 GG genotype was longer compared to that observed in ABCB1 rs12720464 AG genotype (56.77 ± 14.23 minutes vs. 49.50 ± 10.49 minutes, and 62.58 ± 18.16 minutes vs. 53.20 ± 12.56 minutes, respectively, p < 0.05). Further, the time to spontaneous recovery of TOF 0.7/0.8/0.9 in ABCB1 rs1055302 GG genotype was longer than that in ABCB1 rs1055302 AG genotype (52.00 ± 12.10 minutes vs. 44.83 ± 7.38 minutes, 55.96 ± 13.92 minutes vs. 46.83 ± 7.67 minutes, 61.66 ± 17.70 minutes vs. 49.50 ± 8.44 minutes, respectively, p < 0.05).
  
  
  CONCLUSIONS
  In Chinese patients who were administered a single dose of rocuronium, the genetic variants ABCB1 rs12720464, and rs1055302 contribute to the individual< variability of time course of action.
authors.forename: Tian-long
authors.initials: TL
authors.lastname: Qi
authors.forename: Yin-hui
authors.initials: YH
authors.lastname: Zhou
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Yuan
authors.forename: Zhi-song
authors.initials: ZS
authors.lastname: Li
authors.forename: Zhong-yu
authors.initials: ZY
authors.lastname: Wang
authors.forename: Yan-zi
authors.initials: YZ
authors.lastname: Chang
authors.forename: Er-xian
authors.initials: EX
authors.lastname: Zhao
authors.forename: Dan
authors.initials: D
authors.lastname: Cheng
authors.forename: Jun-kai
authors.initials: JK
authors.lastname: Hou
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Ge-zi
authors.initials: GZ
authors.lastname: Chen
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Mao
authors.forename: Yang
authors.initials: Y
authors.lastname: Ren
authors.forename: Li-rong
authors.initials: LR
authors.lastname: Zhang
authors.forename: Quan-cheng
authors.initials: QC
authors.lastname: Kan
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D000732:Androstanols / Q000494:pharmacology*; D044466:Asian People / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D020641:Polymorphism, Single Nucleotide; D000077123:Rocuronium
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium