title: Is 2% chlorhexidine gluconate in 70% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)?
abstract: A pilot randomized trial in 3 Irish outpatient hemodialysis units compared 2% chlorhexidine gluconate (CHG) in 70% isopropyl alcohol with routinely used CHG solutions for central venous catheter exit site antisepsis. We found no significant difference between the groups for the prevention of catheter-related bloodstream infections (1/53 vs 2/52; relative risk [RR], 0.49; 95% confidence interval [CI], 0.05-5.25; P = .55) and catheter-associated bloodstream infections (1/53 vs 4/52; RR, 0.25; 95% CI, 0.03-2.12; P = .16).
authors.affiliation: School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland. Electronic address: mccannm1@tcd.ie.
authors.forename: Margaret
authors.initials: M
authors.lastname: McCann
authors.affiliation: Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Microbiology, Beaumont Hospital, Dublin, Ireland.
authors.forename: Fidelma
authors.initials: F
authors.lastname: Fitzpatrick
authors.affiliation: School of Medicine Trinity College Dublin, Dublin, Ireland; Trinity Kidney Health Centre, Tallaght Hospital, Dublin, Ireland.
authors.forename: George
authors.initials: G
authors.lastname: Mellotte
authors.affiliation: School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland; Northern Ireland Network for Trials Methodology Research, Queen's University Belfast, Belfast, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Clarke
mesh_terms: D019840:2-Propanol / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D055499:Catheter-Related Infections / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000379:methods*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004203:Disinfection / Q000379:methods*; D005260:Female; D006801:Humans; D007494:Ireland; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; C010882:chlorhexidine gluconate; D019840:2-Propanol; D002710:Chlorhexidine
keywords: Hemodialysis; central venous catheters; chlorhexidine gluconate; clinical trial; infection prevention; skin cleansing