title: Outbreak of blaOXA-72-producing Acinetobacter baumannii in South America.
abstract: Thirty-five Acinetobacter baumannii isolates were recovered from two medical centres in Guayaquil City, Ecuador, from November 2012 to October 2013. Isolates were identified using MALDI-TOF and confirmed by rpoB. PCR methods were employed for epidemiological analysis.Thirty-three A. baumannii isolates were resistant to all β-lactams. The blaOXA-24/40-like gene was detected in 30 isolates. DNA sequencing identified the blaOXA-24/40-like amplicon as blaOXA-72.The 30 isolates harbouring blaOXA-72strains showed the same PCR pattern. We report the first outbreak of blaOXA-72-producing A. baumannii in South America. This is the first study carried out in the Republic of Ecuador.
authors.affiliation: a Hospital IESS "Teodoro Maldonando Carbo" , Guayaquil , Ecuador.
authors.forename: Tamara
authors.initials: T
authors.lastname: Nuñez Quezada
authors.affiliation: b Laboratorio de Bacteriología, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica , Hospital de Clínicas José de San Martín, Universidad de Buenos Aires , Buenos Aires , Argentina.
authors.forename: Carlos Hernan
authors.initials: CH
authors.lastname: Rodríguez
authors.affiliation: c Hospital de Infectología "José Daniel Rodríguez Maridueña" , Guayaquil , Ecuador.
authors.forename: Glenda
authors.initials: G
authors.lastname: Castro Cañarte
authors.affiliation: b Laboratorio de Bacteriología, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica , Hospital de Clínicas José de San Martín, Universidad de Buenos Aires , Buenos Aires , Argentina.
authors.forename: Marcela
authors.initials: M
authors.lastname: Nastro
authors.affiliation: b Laboratorio de Bacteriología, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica , Hospital de Clínicas José de San Martín, Universidad de Buenos Aires , Buenos Aires , Argentina.
authors.forename: Nora
authors.initials: N
authors.lastname: Balderrama Yarhui
authors.affiliation: b Laboratorio de Bacteriología, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica , Hospital de Clínicas José de San Martín, Universidad de Buenos Aires , Buenos Aires , Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Dabos
authors.affiliation: a Hospital IESS "Teodoro Maldonando Carbo" , Guayaquil , Ecuador.
authors.forename: Yessenia
authors.initials: Y
authors.lastname: Acosta Mosquera
authors.affiliation: a Hospital IESS "Teodoro Maldonando Carbo" , Guayaquil , Ecuador.
authors.forename: Natasha
authors.initials: N
authors.lastname: Plaza Moreira
authors.affiliation: b Laboratorio de Bacteriología, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica , Hospital de Clínicas José de San Martín, Universidad de Buenos Aires , Buenos Aires , Argentina.
authors.forename: Angela
authors.initials: A
authors.lastname: Famiglietti
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D004196:Disease Outbreaks; D005798:Genes, Bacterial / Q000235:genetics*; D006761:Hospitals; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017422:Sequence Analysis, DNA / Q000379:methods; D013020:South America / Q000453:epidemiology; D001618:beta-Lactamases / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases
keywords: Acinetobacter baumannii; America; Carbapenem-resistance; OXA-72; OXA-type β-lactamase