title: Anti Saccharomyces cerevisiae Antibodies in Patients With Anti-β2 Glycoprotein I Antibodies.
abstract: BACKGROUND
  In this study, cross-reactive epitopes on β2 glycoprotein I and Saccharomyces cerevisiae have been described. The objective of our study was to determine the frequency of anti S. cerevisiae antibodies (ASCA) in patients with anti-β2 glycoprotein I antibodies (aβ2GPI).
  
  
  METHODS
  A retrospective study was conducted in 77 patients with aβ2GPI (aβ2GPI-IgG or aβ2GPI-IgA). Eighty blood donors were used as a control group. ASCA IgG and ASCA IgA were determined by Enzyme Linked Immunosorbent Assay (ELISA).
  
  
  RESULTS
  Thirteen patients among 77 had ASCA. ASCA (IgA or IgG) was significantly more frequent in patients than in healthy subjects (16.9% vs. 3.7%, P = 0.01). The positivity of both ASCA IgG and ASCA IgA is higher in patients than in control group (6.5% vs. 0%, P = 0.02). The frequency of ASCA IgG was significantly higher in patients than in the control group (15.6% vs. 2.5%, P = 0.009). In females, the frequency of ASCA IgG was significantly higher in patients than in control group (17.5% vs. 3.7%, P = 0.03). The average titer of ASCA IgG was significantly higher in patients than in the control group (9.7 ± 23 U/ml vs. 2.2 ± 2.8 U/ml; P = 0.004). ASCA IgG was significantly more frequent than ASCA IgA in all patients (15.6% vs. 7.8%, P = 0.04).
  
  
  CONCLUSIONS
  The frequency of ASCA was significantly higher in patients with aβ2GPI than in the control group.
authors.affiliation: Research unit (03UR/07-02), Faculty of Pharmacy, Monastir University, Monastir, Tunisia.|High School of Sciences and Techniques of Health, Tunis el Manar University, Tunis, Tunisia.
authors.forename: Amani
authors.initials: A
authors.lastname: Mankaï
authors.affiliation: Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia.
authors.forename: Skander
authors.initials: S
authors.lastname: Layouni
authors.affiliation: Research unit (03UR/07-02), Faculty of Pharmacy, Monastir University, Monastir, Tunisia. i_ghedira@yahoo.fr.|Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia. i_ghedira@yahoo.fr.
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Ghedira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000382:microbiology; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012441:Saccharomyces cerevisiae / Q000276:immunology* / Q000472:pathogenicity; D012737:Sex Factors; D014416:Tunisia; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D053482:beta 2-Glycoprotein I
keywords: Tunisia; anti Saccharomyces cerevisiae antibodies; anti-β2 glycoprotein I antibodies