title: Flexible genomic islands as drivers of genome evolution.
abstract: Natural prokaryotic populations are composed of multiple clonal lineages that are different in their core genomes in a range that varies typically between 95 and 100% nucleotide identity. Each clonal lineage also carries a complement of not shared flexible genes that can be very large. The compounded flexible genome provides polyclonal populations with enormous gene diversity that can be used to efficiently exploit resources. This has fundamental repercussions for interpreting individual bacterial genomes. They are better understood as parts rather than the whole. Multiple genomes are required to understand how the population interacts with its biotic and abiotic environment.
authors.affiliation: Evolutionary Genomics Group, Departamento de Producción Vegetal y Microbiología, Universidad Miguel Hernández, San Juan de Alicante, 03550 Alicante, Spain. Electronic address: frvalera@umh.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Rodriguez-Valera
authors.affiliation: Evolutionary Genomics Group, Departamento de Producción Vegetal y Microbiología, Universidad Miguel Hernández, San Juan de Alicante, 03550 Alicante, Spain.
authors.forename: Ana-Belen
authors.initials: AB
authors.lastname: Martin-Cuadrado
authors.affiliation: Evolutionary Genomics Group, Departamento de Producción Vegetal y Microbiología, Universidad Miguel Hernández, San Juan de Alicante, 03550 Alicante, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: López-Pérez
mesh_terms: D001105:Archaea / Q000235:genetics*; D001419:Bacteria / Q000235:genetics*; D001483:Base Sequence; D019143:Evolution, Molecular; D014644:Genetic Variation; D020745:Genome, Archaeal / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D044404:Genomic Islands / Q000235:genetics*; D056186:Metagenomics / Q000379:methods; D011135:Polysaccharides, Bacterial / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D011135:Polysaccharides, Bacterial