title: Effect of initial absolute monocyte count on survival outcome of patients with de novo non-M3 acute myeloid leukemia.
abstract: Increased absolute monocyte count (AMC) at presentation has recently been associated with clinical outcome in different types of hematological malignancies. This study aimed to assess the prognostic value of AMC on survival in 193 adult patients with de novo non-M3 acute myeloid leukemia (AML). The median AMC for all patients at diagnosis was 0.26 × 10(9)/L, with 41.4, 31.1 and 27.5% of patients showed low (<0.12 × 10(9)/L), normal (0.12-0.80 × 10(9)/L), and high AMC (>0.80 × 10(9)/L), respectively. Univariate analysis revealed that high AMC appeared as a poor prognostic factor for overall survival (OS) (p = 0.0055), but not for disease free survival (DFS) (p = 0.1195). On multivariate analysis, initial high AMC remained an independent predictor of OS (hazard ratio 2.01, p = 0.017). Our results suggest that AMC at diagnosis, which provides additional prognostic information independently from conventional factors related to patient clinical characteristics or tumor biological features, could be a novel prognostic marker for AML.
authors.affiliation: a Division of Pediatric Hematology-Oncology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Jianhua
authors.initials: J
authors.lastname: Feng
authors.affiliation: b Division of Hematology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: b Division of Hematology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Junqing
authors.initials: J
authors.lastname: Wu
authors.affiliation: c Laboratory of Internal Medicine , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China.
authors.forename: Shenmeng
authors.initials: S
authors.lastname: Gao
authors.affiliation: b Division of Hematology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Haige
authors.initials: H
authors.lastname: Ye
authors.affiliation: b Division of Hematology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Lan
authors.initials: L
authors.lastname: Sun
authors.affiliation: b Division of Hematology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: b Division of Hematology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Kang
authors.initials: K
authors.lastname: Yu
authors.affiliation: b Division of Hematology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China ;
authors.forename: Chong-Yun
authors.initials: CY
authors.lastname: Xing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood* / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Acute myeloid leukemia; absolute monocyte count; prognosis; survival