title: Palladium/l-Proline-Catalyzed Enantioselective α-Arylative Desymmetrization of Cyclohexanones.
abstract: A highly enantioselective palladium/l-proline-catalyzed α-arylative desymmetrization of cyclohexanones was developed. The new strategy for α-arylation reaction led to a series of optically active morphan derivatives bearing α-carbonyl tertiary stereocenters in good yields with excellent enantioselectivities (up to 99% ee).
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Bao-Le
authors.initials: BL
authors.lastname: Li
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Shen
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Gao
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Yi-Xia
authors.initials: YX
authors.lastname: Jia
mesh_terms: D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003512:Cyclohexanones; D010165:Palladium; D011392:Proline