title: Incorporating parent-of-origin effects in whole-genome prediction of complex traits.
abstract: BACKGROUND
  Parent-of-origin effects are due to differential contributions of paternal and maternal lineages to offspring phenotypes. Such effects include, for example, maternal effects in several species. However, epigenetically induced parent-of-origin effects have recently attracted attention due to their potential impact on variation of complex traits. Given that prediction of genetic merit or phenotypic performance is of interest in the study of complex traits, it is relevant to consider parent-of-origin effects in such predictions. We built a whole-genome prediction model that incorporates parent-of-origin effects by considering parental allele substitution effects of single nucleotide polymorphisms and gametic relationships derived from a pedigree (the POE model). We used this model to predict body mass index in a mouse population, a trait that is presumably affected by parent-of-origin effects, and also compared the prediction performance to that of a standard additive model that ignores parent-of-origin effects (the ADD model). We also used simulated data to assess the predictive performance of the POE model under various circumstances, in which parent-of-origin effects were generated by mimicking an imprinting mechanism.
  
  
  RESULTS
  The POE model did not predict better than the ADD model in the real data analysis, probably due to overfitting, since the POE model had far more parameters than the ADD model. However, when applied to simulated data, the POE model outperformed the ADD model when the contribution of parent-of-origin effects to phenotypic variation increased. The superiority of the POE model over the ADD model was up to 8 % on predictive correlation and 5 % on predictive mean squared error.
  
  
  CONCLUSIONS
  The simulation and the negative result obtained in the real data analysis indicated that, in order to gain benefit from the POE model in terms of prediction, a sizable contribution of parent-of-origin effects to variation is needed and such variation must be captured by the genetic markers fitted. Recent studies, however, suggest that most parent-of-origin effects stem from epigenetic regulation but not from a change in DNA sequence. Therefore, integrating epigenetic information with genetic markers may help to account for parent-of-origin effects in whole-genome prediction.
authors.affiliation: Department of Animal Sciences, University of Wisconsin-Madison, 1675 Observatory Dr., Madison, WI, 53706, USA. yhu32@wisc.edu.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Animal Sciences, University of Wisconsin-Madison, 1675 Observatory Dr., Madison, WI, 53706, USA.|Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI, 53792, USA.
authors.forename: Guilherme J M
authors.initials: GJ
authors.lastname: Rosa
authors.affiliation: Department of Animal Sciences, University of Wisconsin-Madison, 1675 Observatory Dr., Madison, WI, 53706, USA.|Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI, 53792, USA.|Department of Dairy Science, University of Wisconsin-Madison, 1675 Observatory Dr., Madison, WI, 53706, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gianola
mesh_terms: D000465:Algorithms; D000483:Alleles; D000818:Animals; D015992:Body Mass Index; D003198:Computer Simulation; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D018392:Genomic Imprinting / Q000235:genetics*; D023281:Genomics; D008297:Male; D051379:Mice / Q000235:genetics*; D008957:Models, Genetic; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers