title: Nutrigenomic regulation of adipose tissue development - role of retinoic acid: A review.
abstract: To improve the efficiency of animal production, livestock have been extensively selected or managed to reduce fat accumulation and increase lean growth, which reduces intramuscular or marbling fat content. To enhance marbling, a better understanding of the mechanisms regulating adipogenesis is needed. Vitamin A has recently been shown to have a profound impact on all stages of adipogenesis. Retinoic acid, an active metabolite of vitamin A, activates both retinoic acid receptors (RAR) and retinoid X receptors (RXR), inducing epigenetic changes in key regulatory genes governing adipogenesis. Additionally, Vitamin D and folates interact with the retinoic acid receptors to regulate adipogenesis. In this review, we discuss nutritional regulation of adipogenesis, focusing on retinoic acid and its impact on epigenetic modifications of key adipogenic genes.
authors.affiliation: Department of Animal Sciences, Washington State University, Pullman, WA 99164, United States.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Animal Sciences, Washington State University, Pullman, WA 99164, United States.
authors.forename: Qiyuan
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Animal Sciences, Washington State University, Pullman, WA 99164, United States.
authors.forename: Corrine L
authors.initials: CL
authors.lastname: Harris
authors.affiliation: Department of Animal Sciences, Washington State University, Pullman, WA 99164, United States.
authors.forename: Mark L
authors.initials: ML
authors.lastname: Nelson
authors.affiliation: Department of Animal Sciences, Washington State University, Pullman, WA 99164, United States.
authors.forename: Jan R
authors.initials: JR
authors.lastname: Busboom
authors.affiliation: School of Food Science, Washington State University, Pullman, WA 99164, United States.
authors.forename: Mei-Jun
authors.initials: MJ
authors.lastname: Zhu
authors.affiliation: Department of Animal Sciences, Washington State University, Pullman, WA 99164, United States. Electronic address: min.du@wsu.edu.
authors.forename: Min
authors.initials: M
authors.lastname: Du
mesh_terms: D050156:Adipogenesis / Q000187:drug effects / Q000235:genetics; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D019175:DNA Methylation / Q000187:drug effects; D057890:Epigenomics; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005492:Folic Acid / Q000494:pharmacology; D005786:Gene Expression Regulation; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D054647:Nutrigenomics; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism; D047488:Retinoid X Receptors / Q000235:genetics / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*; D014807:Vitamin D / Q000494:pharmacology
chemical_list: D050556:Fatty Acid-Binding Proteins; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014807:Vitamin D; D014212:Tretinoin; D005492:Folic Acid
keywords: Adipogenesis; Marbling; Meat; Progenitor cells; Retinoic acid; Vitamin A