title: Cancer incidence in Priolo, Sicily: a spatial approach for estimation of industrial air pollution impact.
abstract: The territory around the industrial Sicilian area of Priolo, Italy, has been defined as a contaminated site (CS) of national priority for remediation because of diffuse environmental contamination caused by large industrial settlements. The present study investigates the spatial distribution of cancer into the CS territory (period 1999-2006). Different geographical methods used for the evaluation of the impact of industrial air pollutants were adopted. Using the database of Syracuse Province Cancer Registry, gender-specific standardised incidence ratios were calculated for 35 tumour sites for the CS overall and for each municipality included in the CS. A cluster analysis for 17 selected neoplasms was performed at micro-geographical level. The identification of the priority index contaminants (PICs) present in environmental matrices and a review of their carcinogenicity have been performed and applied in the interpretation of the findings. The area has a higher cancer incidence with respect to the provincial population, in particular excess is registered among both genders of lung, bladder and breast cancers as well as skin melanoma and pleural mesothelioma and there is an a priori evidence of association with the exposure to PICs. The study highlights the need to provide different approaches in CSs where several exposure pathways might be relevant for the population. The presence of potential sources of asbestos exposure deserves specific concern.
authors.affiliation: Department of Environment and Primary Prevention, National Institute of Health, Rome. lucia.fazzo@iss.it.
authors.forename: Lucia
authors.initials: L
authors.lastname: Fazzo
authors.forename: Mario
authors.initials: M
authors.lastname: Carere
authors.forename: Francesco
authors.initials: F
authors.lastname: Tisano
authors.forename: Caterina
authors.initials: C
authors.lastname: Bruno
authors.forename: Achille
authors.initials: A
authors.lastname: Cernigliaro
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Cicero
authors.forename: Pietro
authors.initials: P
authors.lastname: Comba
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Contrino
authors.forename: Marco
authors.initials: M
authors.lastname: De Santis
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Falleni
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ingallinella
authors.forename: Anselmo
authors.initials: A
authors.lastname: Madeddu
authors.forename: Ida
authors.initials: I
authors.lastname: Marcello
authors.forename: Carlo
authors.initials: C
authors.lastname: Regalbuto
authors.forename: Giovanna
authors.initials: G
authors.lastname: Sciacca
authors.forename: Maria Eleonora
authors.initials: ME
authors.lastname: Soggiu
authors.forename: Amerigo
authors.initials: A
authors.lastname: Zona
mesh_terms: D000397:Air Pollution / Q000009:adverse effects* / Q000706:statistics & numerical data; D002274:Carcinogens, Environmental / Q000009:adverse effects; D016000:Cluster Analysis; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D012802:Sicily / Q000453:epidemiology; D062206:Spatial Analysis
chemical_list: D002274:Carcinogens, Environmental