title: Repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorders: Double blind randomized clinical trial.
abstract: Repetitive transcranial magnetic stimulation (rTMS) has become widely used as a therapeutic tool in psychiatric research. The aim of this study was to evaluate the impact of different frequencies of rTMS over right dorsolateral prefrontal cortex (DLPFC) in OCD. Forty five patients with OCD participated in the study. Patients were evaluated using: Yale-Brown obsessive compulsive scale (Y-BOCS), Hamilton Anxiety Rating Scale (HAM-A), and Clinical Global Impression-Severity scale (CGI-S). They were randomly classified into three groups: 1st group received 1Hz rTMS; 2nd group received 10Hz rTMS; and 3rd group received sham stimulation all at 100% of the resting motor threshold for 10 sessions. They were followed up after the last treatment session and 3 months later. There was a significant "time"×"group" interaction for 1Hz versus Sham but not for 10Hz versus Sham. 1Hz versus 10Hz groups showed a significant interaction for Y-BOCS and HAM-A (P=0.001 and 0.0001 respectively). 1Hz rTMS has a greater clinical benefit than 10Hz or Sham. There was also a significantly larger percentage change in GCI-S in the 1Hz group versus either 10Hz or sham. We conclude that 1Hz-rTMS, targeting right DLPFC is a promising tool for treatment of OCD.
authors.affiliation: Neuropsychiatry Department, Assiut University Hospital, Assiut, Egypt.
authors.forename: Khaled A M
authors.initials: KAM
authors.lastname: Elbeh
authors.affiliation: Neuropsychiatry Department, Assiut University Hospital, Assiut, Egypt.
authors.forename: Yasser M B
authors.initials: YMB
authors.lastname: Elserogy
authors.affiliation: Neuropsychiatry Department, Assiut University Hospital, Assiut, Egypt.
authors.forename: Hossam E
authors.initials: HE
authors.lastname: Khalifa
authors.affiliation: Neuropsychiatry Department, Assiut University Hospital, Assiut, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ahmed
authors.affiliation: Neuropsychiatry Department, Assiut University Hospital, Assiut, Egypt.
authors.forename: Mahmoud H
authors.initials: MH
authors.lastname: Hafez
authors.affiliation: Neuropsychiatry Department, Assiut University Hospital, Assiut, Egypt. Electronic address: emankhedr99@yahoo.com.
authors.forename: Eman M
authors.initials: EM
authors.lastname: Khedr
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Clinical global impression-severity scale (CGI-S); Clinical trial; Hamilton anxiety rating scale (HAM-A); OCD; Yale-Brown obsessive compulsive scale (Y-BOCS); rTMS