title: Adalimumab: Another Medication Related to Osteonecrosis of the Jaws?
abstract: Objective. The acronym MRONJ has been created in order to identify "Medication-Related Osteonecrosis of the Jaw," observed after the use of Bisphosphonates, RANK ligand inhibitor, and antiangiogenic medications. Only a case of osteonecrosis of the jaw in a Chron's disease patient following a course of Bisphosphonate and Adalimumab therapy has been recently described, so that it has been supposed that also this medication could promote manifestation of osteonecrosis. Clinical Case. On August, 2014, a 63-year-old female with a history of idiopathic arthritis treated with medical treatment with Adalimumab from 2010 to 2013 presented referring pain in the right mandible. Results. This patient presented with nonexposed osteonecrosis of the jaw after placement, on September, 2010, of four titanium fixtures in the mandible. Conclusions. The authors suggest that the biologic therapy with an anti-TNF-α antibody might promote the manifestation of osteonecrosis and compromise oral healing capacity of the bone.
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cassoni
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Romeo
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Terenzi
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Della Monaca
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Oriana
authors.initials: O
authors.lastname: Rajabtork Zadeh
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Raponi
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Fadda
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Polimeni
authors.affiliation: Odontostomatological Science and Maxillo facial Surgery Department, "Sapienza" University of Rome, 00161 Rome, Italy.
authors.forename: Valentino
authors.initials: V
authors.lastname: Valentini