title: Association of telomere length with IL-6 levels during an obesity treatment in adolescents: interaction with the-174G/C polymorphism in the IL-6gene.
abstract: Shorter telomeres have been associated with elevated risk for age-related diseases. However, little is known about the biomarker role of telomere length (TL) for predicting inflammation and glucose alterations.
  
  
  
  The objective of this research is to evaluate the association between TL, inflammatory markers and glucose levels after a 2-month weight-loss programme in obese adolescents.
  
  
  
  Telomere length was measured using a quantitative polymerase chain reaction in 66 obese adolescents aged 12-17 years (51% men) from the EVASYON programme. The adolescents were genotyped for the polymorphism -174G/C (rs1800795) in the IL-6gene, and anthropometric and biochemical markers as well as inflammatory cytokines were analysed.
  
  
  
  Multiple-adjusted models showed that longer telomeres at baseline were associated with a higher reduction in glucose (B = -4.08, 95% confidence interval: -6.66 to -1.50) and IL-6 (B = -1.03, 95% confidence interval: -2.01 to -0.05) serum levels after 2 months of the weight-loss treatment. The -174G/C polymorphism modulated the association between basal TL and changes in IL-6 (P interaction = 0.029). Thus, subjects with the GG + GC genotype and with longer telomeres showed a higher decrease in IL-6 levels than CC homozygotes.
  
  
  
  Longer telomeres are associated with an improvement in glucose tolerance and inflammation after a weight-loss programme in obese adolescents. Moreover, the -174G/C polymorphism may influence the relationship between TL and IL-6 changes.
authors.affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.|IdiSNA Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: García-Calzón
authors.affiliation: Making Genetics S.L., Noain, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Moleres
authors.affiliation: Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology, and Nutrition, Spanish National Research Council, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Gómez-Martinez
authors.affiliation: Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology, and Nutrition, Spanish National Research Council, Madrid, Spain.
authors.forename: L E
authors.initials: LE
authors.lastname: Diaz
authors.affiliation: Growth, Exercise, Nutrition and Development (GENUD) Research Group, Facultad de Ciencias de la Salud, University of Zaragoza, Zaragoza, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Bueno
authors.affiliation: Pediatric Department, Medicine School, Universidad de Granada, Granada, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Campoy
authors.affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.|IdiSNA Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Martinez
authors.affiliation: Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology, and Nutrition, Spanish National Research Council, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Marcos
authors.affiliation: Pediatric Endocrinology Unit, Department of Paediatrics, University of Navarra Hospital, Pamplona, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Azcona-Sanjulián
authors.affiliation: IdiSNA Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.|Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Zalba
authors.affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.|IdiSNA Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Marti
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D015415:Biomarkers; D001786:Blood Glucose / Q000235:genetics; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D063766:Pediatric Obesity / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D011110:Polymorphism, Genetic; D060888:Real-Time Polymerase Chain Reaction; D016615:Telomere / Q000235:genetics*; D061217:Weight Reduction Programs / Q000379:methods*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D015850:Interleukin-6
keywords: Inflammation; telomeres; weight-loss programme; young population