title: Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells.
abstract: Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the HSP90 family, controls a variety of physiological functions, including cell proliferation, differentiation, and survival. Most studies have been devoted to understanding the anti-apoptotic roles of TRAP1 in cancer and targeting it for tumor control in clinical settings. Additionally, we have identified a new role for TRAP1 in regulation of liver regeneration after partial hepatectomy in TRAP1 transgenic mice and cellular proliferation in TRAP1-overexpressing cells, via mitochondrial alterations. Moreover, recent works have indicated a role for TRAP1 in the regulation of cancer stem cells (CSCs) as well as a metabolic switch between mitochondrial respiration and aerobic glycolysis called as "Warburg effect." This review discusses the implications of TRAP1 action for both metabolism and the regulation of CSCs.
authors.affiliation: Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea. milybud@gmail.com.|Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea. milybud@gmail.com.|Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea. milybud@gmail.com.
authors.forename: Chang-Nim
authors.initials: CN
authors.lastname: Im
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000502:physiology; D006019:Glycolysis / Q000502:physiology; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008115:Liver Regeneration / Q000502:physiology; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*
chemical_list: D018841:HSP90 Heat-Shock Proteins; C092306:TRAP1 protein, human
keywords: Apoptosis; Cancer stem cells; Fatty liver; TRAP1; Warburg effect