title: Craniosynostosis and Resynostosis: Models, Imaging, and Dental Implications.
abstract: Craniosynostosis occurs in approximately 1 in 2,000 children and results from the premature fusion of ≥1 cranial sutures. If left untreated, craniosynostosis can cause numerous complications as related to an increase in intracranial pressure or as a direct result from cranial deformities, or both. More than 100 known mutations may cause syndromic craniosynostosis, but the majority of cases are nonsyndromic, occurring as isolated defects. Most cases of craniosynostosis require complex cranial vault reconstruction that is associated with a high risk of morbidity. While the first operation typically has few complications, bone rapidly regrows in up to 40% of children who undergo it. This resynostosis typically requires additional surgical intervention, which can be associated with a high incidence of life-threatening complications. This article reviews work related to the dental and maxillofacial implications of craniosynostosis and discusses clinically relevant animal models related to craniosynostosis and resynostosis. In addition, information is provided on the imaging modalities used to study cranial defects in animals and humans.
authors.affiliation: School of Medicine, Emory University, Atlanta, GA, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Hermann
authors.affiliation: Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Hyzy
authors.affiliation: Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Olivares-Navarrete
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Walker
authors.affiliation: Children's Healthcare of Atlanta, Atlanta, GA, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Williams
authors.affiliation: Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA bdboyan@vcu.edu.
authors.forename: B D
authors.initials: BD
authors.lastname: Boyan
authors.affiliation: Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D002648:Child; D003393:Cranial Sutures / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D003398:Craniosynostoses / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D011817:Rabbits; D014057:Tomography, X-Ray Computed; D014071:Tooth Abnormalities / Q000473:pathology
keywords: animal models; maxillofacial; osteogenesis; review; sutures; three-dimensional imaging