title: The Peripheral Blood Mononuclear Cell Count Is Associated With Bone Health in Elderly Men: A Cross-Sectional Population-Based Study.
abstract: The peripheral blood mononuclear cell (PBMC) count is a routinely used and meaningful index for infection and blood diseases. PBMCs may be closely related to osteoclasts and include osteoclast precursors; we examined the association between the PBMC count and bone health. This research included 2806 community men aged ≥50 years who underwent full health examinations from October 2007 through December 2011 in four medical centers. The PBMC count was significantly high among subjects with "at least osteopenia" compared with controls. In analysis of covariance adjusted for potential confounders, the bone mineral density (BMD) value and T-score had a significant decreasing trend across the quartiles of PBMC count. In univariate analysis, the PBMC count had a strong association with "at least osteopenia" (odds ratio [OR] = 2.520, 95% confidence interval [CI]: 1.397-4.547). After adjustment for confounding factors (multivariate analysis) from Model 1 to 4, PBMC count remained as an independent risk factor for "at least osteopenia" (OR = 2.481, 95% CI: 1.176-5.236). Moreover, after adjusting for all confounding variables, participants had a significantly high OR in the body mass index (BMI) <25 group (OR = 2.798, CI: 1.122-6.973; P = 0.027) and systolic blood pressure (SBP) <140 group (OR = 2.519, CI: 1.059-5.993; P = 0.037). In conclusion, the PBMC count is significantly associated with bone loss in elderly men and the exact mechanism requires further clarification.
authors.affiliation: From the Department of Orthopedic Surgery, Sir Run Run Shaw Hospital (XL, HY, KH, JM, XF, SF); Department of Orthopedic Surgery, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou (CZ); Department of Orthopedic Surgery, Shaoxing People's Hospital, Shaoxing (YQ); Department of Orthopedic Surgery, Taizhou Hospital of Wenzhou Medical University, Linhai (DH); and Department of Orthopedic, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (AQ), China.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Lin
authors.forename: Hejun
authors.initials: H
authors.lastname: Yu
authors.forename: Chenchen
authors.initials: C
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Qian
authors.forename: Dun
authors.initials: D
authors.lastname: Hong
authors.forename: Kangmao
authors.initials: K
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Mo
authors.forename: An
authors.initials: A
authors.lastname: Qin
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Fang
authors.forename: Shunwu
authors.initials: S
authors.lastname: Fan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood*; D003430:Cross-Sectional Studies; D006801:Humans; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors