title: Risk Assessment of Alzheimer's Disease using the Information Diffusion Model from Structural Magnetic Resonance Imaging.
abstract: Recently, automatic risk assessment methods have been a target for the detection of Alzheimer's disease (AD) risk.
  
  
  
  This study aims to develop an automatic computer-aided AD diagnosis technique for risk assessment of AD using information diffusion theory.
  
  
  
  Information diffusion is a fuzzy mathematics logic of set-value that is used for risk assessment of natural phenomena, which attaches fuzziness (uncertainty) and incompleteness. Data were obtained from voxel-based morphometry analysis of structural magnetic resonance imaging.
  
  
  
  The information diffusion model results revealed that the risk of AD increases with a reduction of the normalized gray matter ratio (p > 0.5, normalized gray matter ratio <40%). The information diffusion model results were evaluated by calculation of the correlation of two traditional risk assessments of AD, the Mini-Mental State Examination and the Clinical Dementia Rating. The correlation results revealed that the information diffusion model findings were in line with Mini-Mental State Examination and Clinical Dementia Rating results. Application of information diffusion model contributes to the computerization of risk assessment of AD, which has a practical implication for the early detection of AD.
authors.affiliation: Biomedical Image Processing Group, Department of Electrical & Electronic Engineering, Eastern Mediterranean University, Gazimagusa, Mersin, Turkey.
authors.forename: Iman
authors.initials: I
authors.lastname: Beheshti
authors.affiliation: British University of Nicosia, Ozankoy, Kyrinia, via Mersin, Turkey.
authors.forename: Hossain G T
authors.initials: HG
authors.lastname: Olya
authors.affiliation: Biomedical Image Processing Group, Department of Electrical & Electronic Engineering, Eastern Mediterranean University, Gazimagusa, Mersin, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Demirel
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D059906:Neuroimaging; D009483:Neuropsychological Tests; D018570:Risk Assessment
keywords: Alzheimer’s disease; computer-aided AD diagnosis; early detection; gray matter volume; information diffusion theory; risk assessment