title: The association between use of metformin and change in serum CO2 level after administration of contrast medium.
abstract: OBJECTIVE
  To evaluate the changes in serum creatinine and total CO2 levels in patients receiving metformin during administration of contrast medium.
  
  
  METHODS
  Patient records from January 2012 to December 2012 after the administration of contrast medium were reviewed retrospectively. A total of 924 patients were included for the final analysis. Of them, 105 received metformin during contrast medium administration, 112 were taking other oral hypoglycaemic agents, and 707 patients were not diabetic (controls).
  
  
  RESULTS
  No significant change in total CO2 levels was detected (p=0.678). Metabolic acidosis was present in 33 (31.4%) metformin users, 31 (28.6%) other oral hypoglycaemic agent users, and 153 (21.6%) control patients. In the present logistic regression analysis, age, baseline levels of creatinine, and total CO2 levels were associated with metabolic acidosis after contrast medium exposure.
  
  
  CONCLUSIONS
  These data indicate the presence of a coexisting risk factor, other than metformin use, associated with metabolic acidosis after contrast medium exposure. No relationship was found between the use of metformin and metabolic acidosis during contrast medium exposure.
authors.affiliation: Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea; Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Gyeongsang National University School of Medicine, Jinju, Republic of Korea; Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea; Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: J
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea; Gyeongsang National University School of Medicine, Jinju, Republic of Korea; Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea.
authors.forename: K Y
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
authors.forename: J-H
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea; Gyeongsang National University School of Medicine, Jinju, Republic of Korea; Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea. Electronic address: jrhahm@gnu.ac.kr.
authors.forename: J R
authors.initials: JR
authors.lastname: Hahm
mesh_terms: D000138:Acidosis / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D000284:Administration, Oral; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood*; D015897:Comorbidity; D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects; D003404:Creatinine / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008687:Metformin / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D003287:Contrast Media; D007004:Hypoglycemic Agents; D002245:Carbon Dioxide; D008687:Metformin; D003404:Creatinine