title: Crystalline mesophases: Structure, mobility, and pharmaceutical properties.
abstract: Crystalline mesophases, which are commonly classified according to their translational, orientational, and conformational order as liquid crystals, plastic crystals, and conformationally disordered crystals, represent a common state of condensed matter. As an intermediate state between crystalline and amorphous materials, crystalline mesophases resemble amorphous materials in relation to their molecular mobility, with the glass transition being their common property, and at the same time possessing a certain degree of translational periodicity (with the exception of nematic phase), with corresponding narrow peaks in X-ray diffraction patterns. For example, plastic crystals, which can be formed both by near-spherical molecules and molecules of lower symmetry, such as planar or chain molecules, can have both extremely sharp X-ray diffraction lines and exhibit glass transition. Fundamentals of structural arrangements in mesophases are compared with several types of disorder in crystalline materials, as well as with short-range ordering in amorphous solids. Main features of the molecular mobility in crystalline mesophases are found to be generally similar to amorphous materials, although some important differences do exist, depending on a particular type of mobility modes involved in relaxation processes. In several case studies reviewed, chemical stability appears to follow the extent of disorder, with the stability of crystalline mesophase found to be intermediate between amorphous (least stable) and crystalline (most stable) materials. Finally, detection of crystalline mesophases during manufacturing of two different types of dosage forms is discussed.
authors.affiliation: Allergan plc, 2525 Dupont Drive, Irvine, CA 92612, USA.
authors.forename: Evgenyi
authors.initials: E
authors.lastname: Shalaev
authors.affiliation: Allergan plc, 2525 Dupont Drive, Irvine, CA 92612, USA.
authors.forename: Ke
authors.initials: K
authors.lastname: Wu
authors.affiliation: Pfizer, Inc., Groton, CT 06340, USA.
authors.forename: Sheri
authors.initials: S
authors.lastname: Shamblin
authors.affiliation: Pfizer, Inc., Groton, CT 06340, USA.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Krzyzaniak
authors.affiliation: University of Lille, UMET (Unité Matériaux Et Transformations), 59655 Villeneuve d'Ascq CEDEX, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Descamps
mesh_terms: D003460:Crystallization; D004364:Pharmaceutical Preparations; D014961:X-Ray Diffraction
chemical_list: D004364:Pharmaceutical Preparations
keywords: Amorphous; Condensed phase; Disorder; Glass transition; Liquid crystals; Molecular mobility; Phase diagram; Plastic crystals