title: [Glutamate dehydrogenase activity in platelets of patients with endogenous psychosis].
abstract: OBJECTIVE
  to evaluation of glutamate dehydrogenase (GDH) enzymatic activity in platelets of patients with endogenous psychoses.
  
  
  METHODS
  Enzymatic cectivity of GDH evaluated in 69 patients with schizophrenia (n=48) or schizoaffective disorder (n=21) in comparison with control group (n=34) and elucidation of possible link between their platelet GDH activity and clinical psychopathological condition.
  
  
  CONCLUSIONS
  Generally, GDH activity in patients before antipsychotic treatment was significantly lower, than in control group. Significant differences were revealed in GDH activity before the treatment between subgroups of patients with first episode psychosis (FEP, n=34), chronic patients (n=35), and control group (n=34), wherein GDH activity correlated with PANSS in FEP patients before the treatment course. No links were found in patients with chronic schizophrenia. Besides, significant links between GDH activity determined before the treatment course and PANSS scores after the treatment were found in FEP patients: the higher were levels of platelet GDH activity in FEP patients, the lower were their PANSS scores after the treatment.
  
  
  CONCLUSIONS
  Initial (baseline) levels of platelet GDH activity can have value for prognosis of antipsychotic pharmacotherapy efficacy in patients with FEP.
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: Т А
authors.initials: ТА
authors.lastname: Prokhorova
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: I S
authors.initials: IS
authors.lastname: Boksha
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: O K
authors.initials: OK
authors.lastname: Savushkina
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: E B
authors.initials: EB
authors.lastname: Tereshkina
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: Е А
authors.initials: ЕА
authors.lastname: Vorobyeva
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: A N
authors.initials: AN
authors.lastname: Pomytkin
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: V G
authors.initials: VG
authors.lastname: Kaleda
authors.affiliation: Research Centre of Mental Health, Moscow.
authors.forename: G Sh
authors.initials: GS
authors.lastname: Burbaeva
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000201:enzymology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D006801:Humans; D011379:Prognosis; D011618:Psychotic Disorders / Q000097:blood / Q000178:diet therapy / Q000201:enzymology*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy / Q000201:enzymology
chemical_list: D014150:Antipsychotic Agents; D005969:Glutamate Dehydrogenase