title: BRONCO: Biomedical entity Relation ONcology COrpus for extracting gene-variant-disease-drug relations.
abstract: Comprehensive knowledge of genomic variants in a biological context is key for precision medicine. As next-generation sequencing technologies improve, the amount of literature containing genomic variant data, such as new functions or related phenotypes, rapidly increases. Because numerous articles are published every day, it is almost impossible to manually curate all the variant information from the literature. Many researchers focus on creating an improved automated biomedical natural language processing (BioNLP) method that extracts useful variants and their functional information from the literature. However, there is no gold-standard data set that contains texts annotated with variants and their related functions. To overcome these limitations, we introduce a Biomedical entity Relation ONcology COrpus (BRONCO) that contains more than 400 variants and their relations with genes, diseases, drugs and cell lines in the context of cancer and anti-tumor drug screening research. The variants and their relations were manually extracted from 108 full-text articles. BRONCO can be utilized to evaluate and train new methods used for extracting biomedical entity relations from full-text publications, and thus be a valuable resource to the biomedical text mining research community. Using BRONCO, we quantitatively and qualitatively evaluated the performance of three state-of-the-art BioNLP methods. We also identified their shortcomings, and suggested remedies for each method. We implemented post-processing modules for the three BioNLP methods, which improved their performance.Database URL:http://infos.korea.ac.kr/bronco.
authors.affiliation: Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and.
authors.forename: Kyubum
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and.
authors.forename: Sunwon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and.
authors.forename: Sungjoon
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and.
authors.forename: Sunkyu
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and.
authors.forename: Suhkyung
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and.
authors.forename: Kwanghun
authors.initials: K
authors.lastname: Choi
authors.affiliation: Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue Aurora, CO 80045, USA kangj@korea.ac.kr aikchoon.tan@ucdenver.edu.
authors.forename: Aik Choon
authors.initials: AC
authors.lastname: Tan
authors.affiliation: Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and kangj@korea.ac.kr aikchoon.tan@ucdenver.edu.
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Kang
mesh_terms: D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D066289:Data Curation; D003628:Database Management Systems; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics*; D023281:Genomics; D006801:Humans