title: Eco-friendly microwave-assisted protocol to prepare hyaluronan-fatty acid conjugates and to induce their self-assembly process.
abstract: An environmentally sustainable and energy-efficient synthetic process has been developed to prepare hyaluronan-based nano-sized material. It consists in a microwave-promoted acylation of the hydroxyl function of the polysaccharide with natural fatty acids, performed under solvent-free conditions. The efficient interaction of the solid reagents with the MW radiation accounts for the obtained high yielded products. The self-assembly process of the obtained compounds very fast occurred in an aqueous medium under MW-radiation, thus allowing the development of a green protocol for the nano-particles preparation.
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80138 Naples, Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Calce
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80138 Naples, Italy.
authors.forename: Flavia Anna
authors.initials: FA
authors.lastname: Mercurio
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80138 Naples, Italy.
authors.forename: Marilisa
authors.initials: M
authors.lastname: Leone
authors.affiliation: Institute of Crystallography, National Research Council, 70126 Bari, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Saviano
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80138 Naples, Italy. Electronic address: stefania.deluca@cnr.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: De Luca
mesh_terms: D000215:Acylation; D000812:Anhydrides / Q000737:chemistry; D055772:Green Chemistry Technology; D006361:Heating; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D008041:Linoleic Acids / Q000737:chemistry*; D008823:Micelles; D053758:Nanoparticles; D009829:Oleic Acids / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000812:Anhydrides; D008041:Linoleic Acids; D008823:Micelles; D009829:Oleic Acids; D014867:Water; D006820:Hyaluronic Acid
keywords: Biocompatible process; Hyaluronan-based material; Microwave activation; Nanoparticle preparation; Renewable sources; Solvent-free synthesis