title: Impact of Squamous Differentiation in Breast Carcinoma.
abstract: This study attempted to review the impact of extent of squamous differentiation in 56 infiltrating duct carcinomas (IDC) with squamous differentiation (metaplastic squamous carcinomas [MSC]). Tumors showing 100% squamous elements were labeled as primary squamous carcinomas (PSC; n = 28) and compared with 28 MSC showing lesser squamous components. A clinicopathological comparison revealed that lymphovascular emboli were never seen in any PSC but were noted in 7/28 of other MSC, while perineural invasion was seen only in PSC and not in MSC. Nodal metastasis was significantly more in other MSC as opposed to PSC. Most MSC presented with 2- to 5-cm sized tumors while PSC were 5 to 10 cm in size. PSC showed cystic change while MSC did not. Disease free survival (DFS) for MSC versus PSC was 64% versus 39.8%, while overall survival (OAS) was 72.7% in MSC versus 66.7% in PSC. Tumor stage affected DFS in MSC while none of the factors affected DFS/OAS in PSC. The extent of squamous differentiation affected DFS with best behavior for metaplastic carcinomas showing <40% squamous elements and worse for those with >90% squamous component (P = .024). PSC of breast is an aggressive disease and show distinct clinicopathological features from other MSC, and though the current definition of MSC does not advocate quantifying the squamous element, clearly this affects prognosis.
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Trupti
authors.initials: T
authors.lastname: Pai
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India tanujashet5@gmail.com.
authors.forename: Tanuja
authors.initials: T
authors.lastname: Shet
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Desai
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Asawari
authors.initials: A
authors.lastname: Patil
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Nita
authors.initials: N
authors.lastname: Nair
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Vani
authors.initials: V
authors.lastname: Parmar
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Budrukkar
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sarin
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai, India The Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Badwe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D002454:Cell Differentiation; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor
keywords: breast carcinoma; metaplastic; squamous carcinoma