title: Practical Asymmetric Synthesis of Amathaspiramides B, D, and F.
abstract: The practical asymmetric synthesis of amathaspiramides B, D, and F has been accomplished by utilizing an aza-Barbier allylation as the key step to construct the common intermediate with two adjacent stereocenters. A kinetically controlled cyclization to build the challenging thermodynamically less stable 8R-hemiaminal moiety is also important in the synthesis of amathaspiramide D. The route is readily scalable, and gram quantity of the final product D has been prepared.
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.
authors.forename: Sen-Lin
authors.initials: SL
authors.lastname: Cai
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Song
authors.affiliation: Shanghai Institute of Organic Chemistry, CAS , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Han-Qing
authors.initials: HQ
authors.lastname: Dong
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.|Shanghai Institute of Organic Chemistry, CAS , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.
authors.forename: Xing-Wen
authors.initials: XW
authors.lastname: Sun