title: Restoration of the pubourethral ligament with platelet rich plasma for the treatment of stress urinary incontinence.
abstract: Stress urinary incontinence (SUI) is a major health problem, which affects nearly 20% of adult women and has a detrimental impact on their daily activities and quality of life. Several surgical techniques have been proposed for the treatment of SUI including the Burch colposuspension, retropubic mid-urethral slings (TVT), trans-obturator tapes (TOT), trans-obturator tapes inside out (TVT-O), bladder neck injections and the insertion of an artificial urethral sphincter. All of these treatments aim to either restore the urethral support, which is naturally preserved by the pubourethral ligament (PUL) or to increase the urethral resistance at rest. Most surgical techniques are associated with a variety of intraoperative and postoperative complications. Platelet rich plasma (PRP) is extremely rich in growth factors and cytokines, which regulate tissue reconstruction and has been studied extensively among trauma patients and trauma experimental models. To date, however, there is no evidence to support or oppose its use in women who suffer from SUI due to PUL damage. PRP is an easily produced and relatively inexpensive biologic material. It is produced directly from the patient's blood and is, thus, superior to synthetic materials in terms of potential adverse effects such as from foreign body reaction. In the present article we summarize the existing evidence in the field, which supports the conduct of animal experimental and clinical studies to elucidate the potential role of PRP in treating SUI.
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, University of Athens, Greece; Department of Obstetrics and Gynaecology, Queen's Hospital, Rom Valley Way, Romford, Essex, United Kingdom.
authors.forename: Kostis I
authors.initials: KI
authors.lastname: Nikolopoulos
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, University of Athens, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Pergialiotis
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, University of Athens, Greece.
authors.forename: Despina
authors.initials: D
authors.lastname: Perrea
authors.affiliation: Department of Obstetrics and Gynaecology, St George's University Hospitals NHS Foundation Trust/St George's University of London, United Kingdom.
authors.forename: Stergios K
authors.initials: SK
authors.lastname: Doumouchtsis
mesh_terms: D000328:Adult; D000818:Animals; D001691:Biological Therapy; D016207:Cytokines / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005544:Forecasting; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D008022:Ligaments / Q000187:drug effects / Q000293:injuries / Q000502:physiology*; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D014550:Urinary Incontinence, Stress / Q000503:physiopathology / Q000628:therapy*
chemical_list: D016207:Cytokines; D015718:Fibrin Tissue Adhesive; D036341:Intercellular Signaling Peptides and Proteins