title: Risk of mTOR inhibitors induced severe pneumonitis in cancer patients: a meta-analysis of randomized controlled trials.
abstract: BACKGROUND
  A meta-analysis of randomized controlled trials was performed to determine the overall risk of noninfectious severe pneumonitis associated with mTOR inhibitors (mTORi) in cancer patients.
  
  
  METHODS
  PubMed, EMBASE and oncology conference proceedings were searched for relevant studies.
  
  
  RESULTS
  A total of 8377 patients from 16 randomized controlled trials were included. The incidence of severe pneumonitis associated with mTORi was 1.7% (95% CI: 1.1-2.5%). The use of mTORi significantly increased the risk of severe pneumonitis compared with controls (odds ratio: 3.36; 95% CI: 2.20-5.12). The analysis was stratified for drug types, tumor types, controlled therapy and mTORi-based regimens, but no significant differences in odds ratios were observed.
  
  
  CONCLUSIONS
  mTORi significantly increase the risk of severe pneumonitis in cancer patients.
authors.affiliation: Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Yu-Ge
authors.initials: YG
authors.lastname: Ran
authors.affiliation: Department of Medical Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Kun-Jie
authors.initials: KJ
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D011014:Pneumonia / Q000139:chemically induced*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases
keywords: cancer; mTOR inhibitors; meta-analysis; pneumonitis