title: Terpenoids with anti-inflammatory activity from Abies chensiensis.
abstract: The phytochemical investigation of Abies chensiensis led to the isolation and identification of nine new compounds including eight triterpenoids (1-8) and a new abietane-type diterpene (9), along with three known compounds (10-12). The absolute configuration of 9 was assigned by X-ray diffraction analysis. Compounds 1-11 were evaluated for the anti-inflammatory activity. Among the tested compounds, 1, 2, 5 and 6 exhibited potent inhibitory activity with IC50 values of 15.97, 18.73, 20.18 and 10.97μM, respectively.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Zhao
authors.affiliation: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, PR China.
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Qiu-Yan
authors.initials: QY
authors.lastname: Song
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address: npchem@lzu.edu.cn.
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D028202:Abies / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D000067996:RAW 264.7 Cells; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D010936:Plant Extracts; D013729:Terpenes; D014315:Triterpenes; D009569:Nitric Oxide
keywords: Abies chensiensis; Anti-inflammatory activity; Terpenoids