title: Simultaneous multislice accelerated interleaved EPI DWI using generalized blipped-CAIPI acquisition and 3D K-space reconstruction.
abstract: Simultaneous multislice (SMS) has been proved to be powerful for accelerating single-shot echo-planar imaging (ssh-EPI) based diffusion-weighted imaging (DWI), but there are some obstacles for applying SMS to interleaved echo-planar imaging (iEPI) DWI. The primary challenge is to effectively combine slice unfolding for SMS and intershot phase correction for multishot DWI. In this study, a novel acquisition and reconstruction method for SMS-accelerated high-resolution iEPI DWI is proposed.
  
  
  
  The traditional blipped-controlled aliasing in parallel imaging (blipped-CAIPI) for ssh-EPI is generalized for iEPI acquisitions. An SMS three-dimensional (3D) navigator acquisition is designed to record the intershot phase variations. Then, slice unfolding and intershot phase correction are performed simultaneously in an SMS 3D k-space. The performance of the proposed method is demonstrated in both four-shot and eight-shot iEPI DWI and compared with ssh-EPI and unaccelerated iEPI DWI.
  
  
  
  The proposed method successfully unfolded the simultaneously excited slices and effectively suppressed artifacts from intershot phase variations. The SMS-accelerated iEPI improved the imaging efficiency, while preserving comparable image quality as unaccelerated iEPI DWI.
  
  
  
  The proposed acquisition and reconstruction is an effective method for accelerating multishot high-resolution DWI, which may be valuable for both neuroscience research and clinical diagnosis. Magn Reson Med 77:1593-1605, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Erpeng
authors.initials: E
authors.lastname: Dai
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.|Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Chun
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: SMS 3D k-space; blipped-CAIPI; diffusion-weighted imaging; high-resolution DWI; interleaved EPI; simultaneous multislice