title: Evaluation of a clinically practical, ERP-based neurometric battery: Application to age-related changes in brain function.
abstract: OBJECTIVE
  Event-related potentials (ERPs) show promise as markers of neurocognitive dysfunction, but conventional recording procedures render measurement of many ERP-based neurometrics clinically impractical. The purpose of this work was (a) to develop a brief neurometric battery capable of eliciting a broad profile of ERPs in a single, clinically practical recording session, and (b) to evaluate the sensitivity of this neurometric profile to age-related changes in brain function.
  
  
  METHODS
  Nested auditory stimuli were interleaved with visual stimuli to create a 20-min battery designed to elicit at least eight ERP components representing multiple sensory, perceptual, and cognitive processes (Frequency & Gap MMN, P50, P3, vMMN, C1, N2pc, and ERN). Data were recorded from 21 younger and 21 high-functioning older adults.
  
  
  RESULTS
  Significant multivariate differences were observed between ERP profiles of younger and older adults. Metrics derived from ERP profiles could be used to classify individuals into age groups with a jackknifed classification accuracy of 78.6%.
  
  
  CONCLUSIONS
  Results support the utility of this design for neurometric profiling in clinical settings.
  
  
  CONCLUSIONS
  This study demonstrates a method for measuring a broad profile of ERP-based neurometrics in a single, brief recording session. These markers may be used individually or in combination to characterize/classify patterns of sensory and/or perceptual brain function in clinical populations.
authors.affiliation: Department of Psychology, College of William and Mary, P.O. Box 8795, Williamsburg, VA 23187-8795, USA. Electronic address: pdkieffaber@wm.edu.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Kieffaber
authors.affiliation: Eastern Virginia Medical School Glennan Center for Geriatrics and Gerontology, 825 Fairfax Avenue, Norfolk, VA 23507, USA. Electronic address: OkhravHR@evms.edu.
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Okhravi
authors.affiliation: Department of Psychology, College of William and Mary, P.O. Box 8795, Williamsburg, VA 23187-8795, USA. Electronic address: jamie.hershaw@usuhs.edu.
authors.forename: Jamie N
authors.initials: JN
authors.lastname: Hershaw
authors.affiliation: Department of Psychology, College of William and Mary, P.O. Box 8795, Williamsburg, VA 23187-8795, USA. Electronic address: eccunn@email.wm.edu.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Cunningham
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult
keywords: EEG; ERP; Evoked potential; Neurometrics