title: Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T.
abstract: OBJECTIVE
  To demonstrate that high resolution (1)H semi-LASER MRSI acquired at 7 T permits discrimination of metabolic patterns of different thalamic nuclei.
  
  
  METHODS
  Thirteen right-handed healthy volunteers were explored at 7 T using a high-resolution 2D-semi-LASER (1)H-MRSI sequence to determine the relative levels of N-Acetyl Aspartate (NAA), choline (Cho) and creatine-phosphocreatine (Cr) in eight VOIs (volume <0.3 ml) centered on four different thalamic nuclei located on the Oxford thalamic connectivity atlas. Post-processing was done using the CSIAPO software. Chemical shift displacement of metabolites was evaluated on a phantom and correction factors were applied to in vivo data.
  
  
  RESULTS
  The global assessment (ANOVA p < 0.05) of the neurochemical profiles (NAA, Cho and Cr levels) with thalamic nuclei and hemispheres as factors showed a significant global effect (F = 11.98, p < 0.0001), with significant effect of nucleus type (p < 0.0001) and hemisphere (p < 0.0001). Post hoc analyses showed differences in neurochemical profiles between the left and the right hemisphere (p < 0.05), and differences in neurochemical profiles between nuclei within each hemisphere (p < 0.05).
  
  
  CONCLUSIONS
  For the first time, using high resolution 2D-PRESS semi-LASER (1)H-MRSI acquired at 7 T, we demonstrated that the neurochemical profiles were different between thalamic nuclei, and that these profiles were dependent on the brain hemisphere.
authors.affiliation: Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France. maxime.donadieu@etu.univ-amu.fr.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France. maxime.donadieu@etu.univ-amu.fr.|Siemens Healthcare, St-Denis, France. maxime.donadieu@etu.univ-amu.fr.
authors.forename: Maxime
authors.initials: M
authors.lastname: Donadieu
authors.affiliation: Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Le Fur
authors.affiliation: Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France.
authors.forename: Sylviane
authors.initials: S
authors.lastname: Confort-Gouny
authors.affiliation: Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Le Troter
authors.affiliation: Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Guye
authors.affiliation: Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ranjeva
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001921:Brain / Q000000981:diagnostic imaging; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007834:Lasers; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging; D019047:Phantoms, Imaging; D010725:Phosphocreatine / Q000031:analogs & derivatives / Q000032:analysis; D012984:Software; D013053:Spectrophotometry; D013788:Thalamus / Q000000981:diagnostic imaging* / Q000378:metabolism; D055815:Young Adult
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; C025403:phosphocreatinine; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
keywords: 1H-MRSI; Connectivity atlas; Neurochemical profiles; Thalamic nuclei; Ultra high field