title: Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model.
abstract: The mechanism underlying pain symptoms in fibromyalgia (FM) is not fully understood. Oxidative stress has emerged as pathophysiological event occurring during the development of the disease. The present study aimed at investigating the efficacy of resveratrol associated with rice bran oil on fibromyalgia-like mice model. Subcutaneous injection of reserpine (0.25 mg/Kg) during 3 days produced fibromyalgia-like symptoms. Resveratrol and/or rice oil or pregabalin were administered through oral route in therapeutic (single dose) and preventive (four doses) schemes. In both schemes, treatment with resveratrol associated with rice bran oil and pregabalin significantly reduced mechanical allodynia and thermal hyperalgesia in animals. The preventive scheme displayed antidepressant effect which was demonstrated by the forced swimming test as well as reduced reactive species in the cerebrospinal fluid of reserpinized animals. Taken together, our data provide evidences that the intake of resveratrol associated with rice bran oil plays antinociceptive and antidepressant actions probably through reducing reactive species and suggests the involvement of oxidative stress in this model of FM as possible underlying mechanism of pathogenesis of the disease.
authors.affiliation: Postgraduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Peres Klein
authors.affiliation: Postgraduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil.
authors.forename: Marcos
authors.initials: M
authors.lastname: Rodrigues Cintra
authors.affiliation: Postgraduate Program in Health Sciences: Medicine and Biomedicine, Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, 30150-240 Belo Horizonte, MG, Brazil.
authors.forename: Nancy
authors.initials: N
authors.lastname: Binda
authors.affiliation: Postgraduate Program in Health Sciences: Medicine and Biomedicine, Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, 30150-240 Belo Horizonte, MG, Brazil.
authors.forename: Danuza
authors.initials: D
authors.lastname: Montijo Diniz
authors.affiliation: Postgraduate Program in Health Sciences: Medicine and Biomedicine, Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, 30150-240 Belo Horizonte, MG, Brazil.
authors.forename: Marcus Vinicius
authors.initials: MV
authors.lastname: Gomez
authors.affiliation: Faculty of Chemistry, Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil.
authors.forename: Andre Arigony
authors.initials: AA
authors.lastname: Souto
authors.affiliation: Postgraduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil; Postgraduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil.
authors.forename: Alessandra Hubner
authors.initials: AH
authors.lastname: de Souza