title: Canine congenital portosystemic shunts: Disconnections dissected.
abstract: Canine congenital portosystemic shunts (CPSS) are vascular anomalies that connect the portal vein with the systemic circulation, therefore bypassing the hepatic parenchyma. Portosystemic shunts exist in two different subtypes: extrahepatic and intrahepatic. This congenital disorder is also described in mice, cat, sheep and man. Research has been focused on pathophysiology, diagnostics and treatment of CPSS and this has resulted in increased knowledge, although the aetiology of the disease remains unclear. This review focuses on the aetiology and genetic basis of both intra- and extrahepatic shunts.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3508 TD, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Van den Bossche
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3508 TD, The Netherlands. Electronic address: f.g.vansteenbeek@uu.nl.
authors.forename: F G
authors.initials: FG
authors.lastname: van Steenbeek
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000151:congenital*; D004285:Dogs / Q000002:abnormalities*; D008099:Liver / Q000098:blood supply; D011169:Portal Vein / Q000002:abnormalities*
keywords: Aetiology; Canine portosystemic shunt; Congenital; Genetics