title: [The fasting calcium/creatinine ratio in patients with calcium stones and the relation with hypercalciuria and phosphocalcium metabolism].
abstract: OBJECTIVE
  To determine the importance of fasting calcium/creatinine ratio in patients with calcium stones and its relation with hypercalciuria and phospho-calcium metabolism.
  
  
  METHODS
  Cross-sectional study including 143 patients divided into two groups according to fasting calcium/creatinine. Group 1: 66 patients (calcium/ creatinine<0.11); Group 2: 77 patients (calcium/ creatinine>0.11). A comparative study is performed between groups including phospho-calcium metabolism parameters and excretion of urinary lithogenic markers. Linear correlation studying calciuria and fasting calcium/ creatinine was performed. SPSS 17.0 statistical analysis software was used, considering p≤0.05.
  
  
  RESULTS
  It is noteworthy that group 2 had increased 24 h urine calcium excretion in comparison to group 1 (229.3 vs 158.1; p=0.0001) and calcium/citrate (0.47 vs 0.34; p=0.001). There is a positive and significant correlation between calcium levels in 24 h urine and fasting calcium/creatinine (R=0.455; p=0.0001) and a cutoff is set at 0.127 (sensitivity 72%, specificity 66%) to determine hypercalciuria (>260 mg in 24 h).
  
  
  CONCLUSIONS
  Increased fasting calcium/creatinine determines increased 24 hours calcium excretion, although the sensitivity and specificity to determine hypercalciuria is not high.
authors.affiliation: UGC Urología. Hospital La Inmaculada. Huércal-Overa. Almería. Spain.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Arrabal-Polo
authors.affiliation: UGC Urología. Hospital La Inmaculada. Huércal-Overa. Almería. Spain.
authors.forename: María
authors.initials: M
authors.lastname: del Carmen Cano-García
authors.affiliation: Instituto IBS Granada. Granada. Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Arrabal-Martín
mesh_terms: D002118:Calcium / Q000378:metabolism / Q000652:urine*; D003404:Creatinine / Q000652:urine*; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D006801:Humans; D053565:Hypercalciuria / Q000209:etiology*; D007669:Kidney Calculi / Q000150:complications* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism
chemical_list: D010758:Phosphorus; D003404:Creatinine; D002118:Calcium