title: Sclerosing angiomatoid nodular transformation of the spleen during pregnancy: Diagnostic challenges and clinical management.
abstract: We report the first case of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed during pregnancy, discussing differential diagnosis, immunohistochemical profile and treatment. A G2P1 37-year-old woman presented during the 19th week of gestation because of pruritus at lower limbs. To exclude cholestasis, an abdominal ultrasound and whole body magnetic resonance were performed and a single solid lesion with intrinsic vascularization was identified. Therefore, at 22 weeks gestation, after normal fetal assessment, the patient was referred for a splenectomy. No further treatment was suggested and the patient gave birth at 42 weeks gestation with a spontaneous delivery. Distinguishing SANT from other vascular neoplasms of the spleen during pregnancy is a difficult task. Surgical excision should be performed to exclude malignancy and to resolve symptoms, if present.
authors.affiliation: Department of Oncological Surgery, Gynecologic Oncologic Unit, "Regina Elena" National Cancer Institute, Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Corrado
authors.affiliation: Division of Pathology, European Institute of Oncology, Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Tabanelli
authors.affiliation: Division of Surgical Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Biffi
authors.affiliation: Division of Radiology, European Institute of Oncology, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Petralia
authors.affiliation: Division of Obstetrics and Gynecology, "Vito Fazzi" Hospital, Lecce, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tinelli
authors.affiliation: Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Fedro A
authors.initials: FA
authors.lastname: Peccatori
mesh_terms: D000328:Adult; D005260:Female; D005865:Gestational Age; D018219:Histiocytoma, Benign Fibrous / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000601:surgery*; D011256:Pregnancy Outcome; D011537:Pruritus / Q000150:complications; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D014463:Ultrasonography
keywords: pregnancy; sclerosing angiomatoid nodular transformation; spleen