title: Phthalocyanine Labels for Near-Infrared Fluorescence Imaging of Solid Tumors.
abstract: Diamagnetic metal complexes of phthalocyanines with n-butoxyl groups in all the α-benzo positions of the macrocycle skeleton, MPc(OBu)8, have strong near-infrared absorptions and intense fluorescences that are Stokes shifted by more than 15 nm. Interestingly, the silicon complex 6 is also remarkably photostable and nontoxic. The use of 6 in the fluorescence imaging of BALB/c mice bearing a 4T1-luc2 tumor in the mammary fat pad unambiguously revealed the presence of the tumor when it was only 1 mm in diameter and was not visible with the naked eye. Compound 6 has an intrinsic ability to accumulate in the tumor, adequate spectroscopic properties, and excellent stability to function as a NIR fluorescent label in the early detection of tumors.
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Ana C S
authors.initials: AC
authors.lastname: Lobo
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Alexandre D
authors.initials: AD
authors.lastname: Silva
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Tomé
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Sara M A
authors.initials: SM
authors.lastname: Pinto
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Elsa F F
authors.initials: EF
authors.lastname: Silva
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Mário J F
authors.initials: MJ
authors.lastname: Calvete
authors.affiliation: Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Faculty of Medicine, University of Coimbra , 3000-548 Coimbra, Portugal.
authors.forename: Célia M F
authors.initials: CM
authors.lastname: Gomes
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Mariette M
authors.initials: MM
authors.lastname: Pereira
authors.affiliation: CQC, Chemistry Department, University of Coimbra , 3004 - 535 Coimbra, Portugal.
authors.forename: Luis G
authors.initials: LG
authors.lastname: Arnaut
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005453:Fluorescence; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D015674:Mammary Neoplasms, Animal / Q000000981:diagnostic imaging*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D061848:Optical Imaging; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; C013647:phthalocyanine