title: GnRH agonist triggering affects the kinetics of embryo development: a comparative study.
abstract: BACKGROUND
  To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system.
  
  
  METHODS
  Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles.
  
  
  METHODS
  Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Göteborg, Sweden).
  
  
  METHODS
  Embryo morphokinetic parameters.
  
  
  RESULTS
  In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles.
  
  
  CONCLUSIONS
  Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.
authors.affiliation: Novafertil IVF Centre, Yeni Meram yolu No:75, Meram, Konya, Turkey. alisamigurbuz@hotmail.com.
authors.forename: Ali Sami
authors.initials: AS
authors.lastname: Gurbuz
authors.affiliation: Department of Obstetrics and Gynecology, Izmir University Hospital, Izmir, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Gode
authors.affiliation: Novafertil IVF Centre, Yeni Meram yolu No:75, Meram, Konya, Turkey.
authors.forename: Mehmet Sukru
authors.initials: MS
authors.lastname: Uzman
authors.affiliation: Novafertil IVF Centre, Yeni Meram yolu No:75, Meram, Konya, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Ince
authors.affiliation: Novafertil IVF Centre, Yeni Meram yolu No:75, Meram, Konya, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Kaya
authors.affiliation: Novafertil IVF Centre, Yeni Meram yolu No:75, Meram, Konya, Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Ozcimen
authors.affiliation: Department of Obstetrics and Gynecology, Baskent University Hospital, Konya, Turkey.
authors.forename: Emel Ebru
authors.initials: EE
authors.lastname: Ozcimen
authors.affiliation: Department of Obstetrics and Gynecology, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Acar
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000628:therapy; D006063:Chorionic Gonadotropin / Q000494:pharmacology* / Q000627:therapeutic use; D046149:Embryo Culture Techniques; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007700:Kinetics; D008297:Male; D065851:Ovarian Reserve; D010062:Ovulation Induction; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D059008:Time-Lapse Imaging; D017329:Triptorelin Pamoate / Q000494:pharmacology*
chemical_list: D006063:Chorionic Gonadotropin; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C061018:ganirelix; C062876:cetrorelix
keywords: Agonist trigger; Embryo quality; Morphokinetic; Oocyte; Time lapse