title: Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry.
abstract: BACKGROUND
  Estrogens are thought to play a critical role in prostate carcinogenesis. It has been suggested that polymorphisms of genes encoding enzymes involved in estrogen metabolism are risk factors for prostate cancer. However, few studies have been performed on populations of African ancestry, which are known to have a high risk of prostate cancer.
  
  
  OBJECTIVE
  We investigated whether functional polymorphisms of CYP17, CYP19, CYP1B1, COMT and UGT1A1 affected the risk of prostate cancer in two different populations of African ancestry.
  
  
  METHODS
  In Guadeloupe (French West Indies), we compared 498 prostate cancer patients and 565 control subjects. In Kinshasa (Democratic Republic of Congo), 162 prostate cancer patients were compared with 144 controls. Gene polymorphisms were determined by the SNaPshot technique or short tandem repeat PCR analysis. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).
  
  
  RESULTS
  The AA genotype and the A allele of rs4680 (COMT) appeared to be inversely associated with the risk of prostate cancer in adjusted models for both Afro-Caribbean and native African men. For the A allele, a significant inverse association was observed among cases with low-grade Gleason scores and localized clinical stage, in both populations.
  
  
  CONCLUSIONS
  These preliminary results support the hypothesis that polymorphisms of genes encoding enzymes involved in estrogen metabolism may modulate the risk of prostate cancer in populations of African ancestry.
authors.affiliation: Inserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.|Service d'Urologie, CHU de Pointe à Pitre, Pointe à Pitre, Guadeloupe, France.|Université des Antilles, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Brureau
authors.affiliation: Service d'Urologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo.
authors.forename: Dieudonné
authors.initials: D
authors.lastname: Moningo
authors.affiliation: Inserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.|Université de Rennes 1, Rennes, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Emeville
authors.affiliation: Université des Antilles, Pointe-à-Pitre, Guadeloupe, France.|Inserm, U1134, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Ferdinand
authors.affiliation: Service d'Urologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo.
authors.forename: Augustin
authors.initials: A
authors.lastname: Punga
authors.affiliation: Service d'Urologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo.
authors.forename: Simon
authors.initials: S
authors.lastname: Lufuma
authors.affiliation: Inserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.|Service d'Urologie, CHU de Pointe à Pitre, Pointe à Pitre, Guadeloupe, France.|Université des Antilles, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Blanchet
authors.affiliation: Université des Antilles, Pointe-à-Pitre, Guadeloupe, France.|Inserm, U1134, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Romana
authors.affiliation: Inserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.|Université de Rennes 1, Rennes, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Multigner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001141:Aromatase / Q000235:genetics; D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics; D065633:Cytochrome P-450 CYP1B1 / Q000235:genetics; D015023:Democratic Republic of the Congo; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics; D014900:West Indies; D000099148:UGT1A1 Enzyme
chemical_list: D001141:Aromatase; D002394:Catechol O-Methyltransferase; D065633:Cytochrome P-450 CYP1B1; D014453:Glucuronosyltransferase; D013254:Steroid 17-alpha-Hydroxylase; D000099148:UGT1A1 Enzyme; C585496:CYP1B1 protein, human; C588010:COMT protein, human