title: Overexpression of JAK2: a predictor of unfavorable prognosis for nasopharyngeal carcinoma.
abstract: OBJECTIVE
  Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status.
  
  
  METHODS
  We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing.
  
  
  RESULTS
  High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression.
  
  
  CONCLUSIONS
  JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.
authors.affiliation: Department of Pathology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan.|Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: He
authors.affiliation: Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital & Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Ying-En
authors.initials: YE
authors.lastname: Lee
authors.affiliation: Department of Pathology, Kaohsiung Medical University Hospital, & Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Peir-In
authors.initials: PI
authors.lastname: Liang
authors.affiliation: Department of Radiation Oncology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
authors.forename: Sung-Wei
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Tzu-Ju
authors.initials: TJ
authors.lastname: Chen
authors.affiliation: Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Ti-Chun
authors.initials: TC
authors.lastname: Chan
authors.affiliation: Department of Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Chung-Hsi
authors.initials: CH
authors.lastname: Hsing
authors.affiliation: Department of Pathology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: I-Wei
authors.initials: IW
authors.lastname: Chang
authors.affiliation: Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: Yow-Ling
authors.initials: YL
authors.lastname: Shiue
authors.affiliation: Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.|National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.|Department of Biotechnology, Southern Taiwan University of Science & Technology, Tainan, Taiwan.|Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Chien-Feng
authors.initials: CF
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma; D004252:DNA Mutational Analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053614:Janus Kinase 2 / Q000032:analysis / Q000096:biosynthesis*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: JAK2; Janus kinase; nasopharyngeal carcinoma; prognosis; transcriptome