title: Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the Kidney of NASH Model Mice.
abstract: Non-alcoholic steatohepatitis (NASH) can be complicated with chronic kidney disease (CKD). In this study, changes in the distribution of biomolecules in the kidney were studied in NASH model mice with the use of imaging mass spectrometry (IMS). The mass spectra and ion images of IMS showed that the signals of cardiolipin (CL) species were decreased in the kidney cortex of the NASH mice. The decrease of CL might therefore suggest the kidney involvement of NASH.
authors.affiliation: Laboratory for Advanced Lipid Analysis, Health Innovation & Technology Center, Faculty of Health Sciences, Hokkaido University.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hayasaka
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Fuda
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Hui
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Chiba
mesh_terms: D000818:Animals; D002308:Cardiolipins / Q000032:analysis*; D004195:Disease Models, Animal; D007668:Kidney / Q000737:chemistry*; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008810:Mice, Inbred C57BL; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis*
chemical_list: D002308:Cardiolipins