title: Commissioning and initial experience with the first clinical gantry-mounted proton therapy system.
abstract: The purpose of this study is to describe the comprehensive commissioning process and initial clinical experience of the Mevion S250 proton therapy system, a gantry-mounted, single-room proton therapy platform clinically implemented in the S. Lee Kling Proton Therapy Center at Barnes-Jewish Hospital in St. Louis, MO, USA. The Mevion S250 system integrates a compact synchrocyclotron with a C-inner gantry, an image guidance system and a 6D robotic couch into a beam delivery platform. We present our commissioning process and initial clinical experience, including i) CT calibration; ii) beam data acquisition and machine characteristics; iii) dosimetric commissioning of the treatment planning system; iv) validation through the Imaging and Radiation Oncology Core credentialing process, including irradiations on the spine, prostate, brain, and lung phantoms; v) evaluation of localization accuracy of the image guidance system; and vi) initial clinical experience. Clinically, the system operates well and has provided an excellent platform for the treatment of diseases with protons.
authors.affiliation: Washington University School of Medicine. tzhao@radonc.wustl.edu.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Zhao
authors.forename: Baozhou
authors.initials: B
authors.lastname: Sun
authors.forename: Kevin
authors.initials: K
authors.lastname: Grantham
authors.forename: Leith
authors.initials: L
authors.lastname: Rankine
authors.forename: Bin
authors.initials: B
authors.lastname: Cai
authors.forename: Sreekrishna M
authors.initials: SM
authors.lastname: Goddu
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Santanam
authors.forename: Nels
authors.initials: N
authors.lastname: Knutson
authors.forename: Tiezhi
authors.initials: T
authors.lastname: Zhang
authors.forename: Michael
authors.initials: M
authors.lastname: Reilly
authors.forename: Beth
authors.initials: B
authors.lastname: Bottani
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bradley
authors.forename: Sasa
authors.initials: S
authors.lastname: Mutic
authors.forename: Eric E
authors.initials: EE
authors.lastname: Klein
mesh_terms: D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009369:Neoplasms / Q000532:radiotherapy*; D056888:Patient Positioning; D019047:Phantoms, Imaging; D061766:Proton Therapy / Q000295:instrumentation* / Q000592:standards*; D011522:Protons; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012399:Rotation; D014057:Tomography, X-Ray Computed
chemical_list: D011522:Protons