title: Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis.
abstract: Non-alcoholic fatty liver disease (NAFLD) can lead to non-alcoholic steatohepatitis (NASH) and cirrhosis. Fibrosis predicts worse outcomes and mortality. New treatments targeting fibrosis are being investigated to reverse disease progression.
  
  
  
  To review the new pipeline therapeutic agents targeting fibrosis in NASH patients, with particular focus on clinical trials in which reversing fibrosis and portal hypertension are the primary outcomes.
  
  
  
  The literature was searched in PubMed between January 2000 and January 2016 using search terms non-alcoholic fatty liver disease and NASH, with filters of 'English language'. We focused on fibrosis improvement as the key outcome. We also searched the ClinicalTrials.gov for promising agents that target fibrosis in NASH patients.
  
  
  
  Significant advances have been made on approaches targeting fibrosis in NASH patients. Many therapeutic agents are already in development, some of which have shown promising results in preclinical and phase I studies. Novel therapies have entered phase II and III studies targeting fibrosis reversal and/or improvement in portal hypertension. Innovative studies have also started looking into combining these agents, aiming at different mechanisms to maximise therapeutic outcomes. We found five clinical trials in phase II and one in phase III focusing on fibrosis in NASH patients as key outcomes. One of the phase II trials is using combination therapy to target fibrosis.
  
  
  
  Ongoing research studies are already investigating new pathways aimed at reversing fibrosis in NASH patients. Novel therapeutic agents are in development and are expected to offer unique options to NASH patients with advanced fibrosis.
authors.affiliation: Fatty Liver Program, Division of Digestive and Liver Diseases, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Noureddin
authors.affiliation: Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
authors.forename: Q M
authors.initials: QM
authors.lastname: Anstee
authors.affiliation: Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.|Division of Epidemiology, University of California, San Diego, La Jolla, CA, USA.|NAFLD Research Center, University of California, San Diego, La Jolla, CA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Loomba
mesh_terms: D018450:Disease Progression; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy*