title: Who Produces Ianthelline? The Arctic Sponge Stryphnus fortis or its Sponge Epibiont Hexadella dedritifera: a Probable Case of Sponge-Sponge Contamination.
abstract: The bromotyrosine derivative ianthelline was isolated recently from the Atlantic boreo-arctic deep-sea sponge Stryphnus fortis, and shown to have clear antitumor and antifouling effects. However, chemosystematics, field observations, and targeted metabolic analyses (using UPLC-MS) suggest that ianthelline is not produced by S. fortis but by Hexadella dedritifera, a sponge that commonly grows on S. fortis. This case highlights the importance of combining taxonomic and ecological knowledge to the field of sponge natural products research.
authors.affiliation: Department of Medicinal Chemistry, Division of Pharmacognosy, BioMedical Centre, Uppsala University, Husargatan 3, 751 23, Uppsala, Sweden. paco.cardenas@fkog.uu.se.
authors.forename: Paco
authors.initials: P
authors.lastname: Cárdenas
mesh_terms: D000818:Animals; D001110:Arctic Regions; D016477:Artifacts; D002851:Chromatography, High Pressure Liquid; D007093:Imidazoles / Q000032:analysis; D013058:Mass Spectrometry; D011161:Porifera / Q000145:classification / Q000378:metabolism*; D013045:Species Specificity; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000096:biosynthesis
chemical_list: D007093:Imidazoles; C577283:ianthelline; D014443:Tyrosine
keywords: Aiolochroia; Bromotyrosine; Chemosystematics; Ianthelline; Porifera; Tetractinellida; Verongiida