title: Gender-specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis.
abstract: Women electing endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) report higher symptom burden but have lower computed tomography (CT) scores. Gender-specific analysis of outcomes from ESS therefore merits further study. The objective of this work was to study gender-specific differences in outcomes from ESS for CRS by analyzing preoperative and postoperative 22-item Sino-Nasal Outcome Test (SNOT-22) scores.
  
  
  
  Data from adult CRS patients electing ESS (2011-2013) were retrospectively collected. SNOT-22 total, rhinologic/nonrhinologic subdomain, and individual item scores were analyzed for gender-specific differences.
  
  
  
  Two hundred and forty-eight patients met study criteria (mean age 55.4 years; 49.6% female). Preoperatively, mean Lund-Mackay CT score was 11.1; average total SNOT-22 score was 41.9. Compared to men, women had lower CT score (10.2 vs 12.0; p = 0.004) but higher total SNOT-22 score (44.7 vs 39.1; p = 0.02). Both genders showed significant improvement in total SNOT-22 scores at 3, 6, 12, and 24 months following ESS (p < 0.001), with largely similar slopes of improvement. The greatest improvement occurred at 3 months (SNOT-22 decreased by 25.4 points), with stable improvement after 12 months (SNOT-22 decreased by 21.3 points). Higher total SNOT-22 scores in females were noted preoperatively and until 6 months post-ESS; these were driven by rhinologic and nonrhinologic-otolaryngic subdomain items. No gender differences in anxiety/depression prevalence or psychological subdomain scores were noted preoperatively or postoperatively.
  
  
  
  Both male and female CRS patients showed significant and durable symptom relief following ESS. Women reported higher symptom burden prior to surgery, and in the early postoperative period. However, after 1-year post-ESS, both genders showed similar symptom scores. The trend and magnitude of improvement were similar in both genders.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic in Arizona, Phoenix, AZ. Lal.devyani@mayo.edu.
authors.forename: Devyani
authors.initials: D
authors.lastname: Lal
authors.affiliation: School of Medicine, University of Arizona, Tucson, AZ.
authors.forename: Kimberly B
authors.initials: KB
authors.lastname: Golisch
authors.affiliation: School of Molecular Sciences, Arizona State University, Tempe, AZ.
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Elwell
authors.affiliation: Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic in Rochester, Rochester, MN.
authors.forename: Rohit D
authors.initials: RD
authors.lastname: Divekar
authors.affiliation: Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic in Arizona, Phoenix, AZ.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Rank
authors.affiliation: Department of Biostatistics, Mayo Clinic in Arizona, Phoenix, AZ.
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Chang
mesh_terms: D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000601:surgery*; D010256:Paranasal Sinuses / Q000601:surgery*; D012220:Rhinitis / Q000601:surgery*; D012852:Sinusitis / Q000601:surgery*; D016896:Treatment Outcome
keywords: chronic rhinosinusitis; chronic sinusitis; endoscopic sinus surgery; gender; outcome