title: Is Insomnia a Risk Factor for Decreased Influenza Vaccine Response?
abstract: Healthy young adult college students (N = 133) with Insomnia (n = 65) or No Insomnia (n = 68) were compared on influenza serum antibody levels pre- and four weeks postvaccination. Volunteers underwent structured clinical interviews for sleep disorders to ensure insomnia diagnoses, as well as psychiatric interviews, physical examinations, and drug testing to ensure comorbid health problems were not potential confounds. There were significant time (both groups had increases in antibody levels pre- to postvaccination) and group (Insomnia group had lower HI antibody levels overall) main effects, but the time × group interaction was nonsignificant. Exploratory analyses did find significant PSQI x Time (p < .001) and Insomnia Status × Time (p = .002) interaction effects. Results indicate insomnia may be a risk factor for lowered immunity to the influenza virus.
authors.affiliation: a Department of Psychology , University of North Texas , Denton , Texas.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Taylor
authors.affiliation: a Department of Psychology , University of North Texas , Denton , Texas.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Kelly
authors.affiliation: b Department of Kinesiology , Iowa State University , Ames , Iowa.
authors.forename: Marian L
authors.initials: ML
authors.lastname: Kohut
authors.affiliation: c Department of Mathematics , University of North Texas , Denton , Texas.
authors.forename: Kai-Sheng
authors.initials: KS
authors.lastname: Song
mesh_terms: D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D008297:Male; D044469:Racial Groups; D012307:Risk Factors; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000276:immunology*; D013334:Students; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines