title: Metal-Free Markovnikov-Type Alkyne Hydration under Mild Conditions.
abstract: A Markovnikov-type alkyne hydration protocol is presented using 20% CF3SO3H (TfOH) as the catalyst under unprecedented mild conditions applicable to various alkynes, including terminal arylalkynes, terminal nonfunctionalized aliphatic alkynes, and internal alkynes with excellent regioselectivity in good to excellent yields (average yields >85%). The reaction procedure operates under mild conditions (25-70 °C), with broad functional group compatibility, and uses only slightly more than a stoichiometric amount of water in the absence of any transition metal. The success of this protocol hinges upon the utilization of trifluoroethanol as the solvent.
authors.affiliation: Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University , 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University , 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.
authors.forename: Haining
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University , 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Li