title: Chemoselective and Sequential Palladium-Catalyzed Couplings for the Generation of Stilbene Libraries via Immobilized Substrates.
abstract: A versatile palladium-catalyzed tandem synthetic sequence to afford E-stilbenes libraries has been developed. Excellent regio- and stereocontrol have been achieved by means of the sequence of Hiyama and Heck cross-couplings. Undesirable homocoupling byproducts were avoided employing immobilized substrates.
authors.affiliation: Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , Suipacha 531, 2000 Rosario, Argentina.
authors.forename: Carla I
authors.initials: CI
authors.lastname: Traficante
authors.affiliation: Laboratorio de Química Farmacéutica, (DQO), Facultad de Química, Universidad de la República , Gral. Flores 2124, Montevideo 11800, Uruguay.
authors.forename: Catherine
authors.initials: C
authors.lastname: Fagundez
authors.affiliation: Laboratorio de Química Farmacéutica, (DQO), Facultad de Química, Universidad de la República , Gral. Flores 2124, Montevideo 11800, Uruguay.
authors.forename: Gloria L
authors.initials: GL
authors.lastname: Serra
authors.affiliation: Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , Suipacha 531, 2000 Rosario, Argentina.
authors.forename: Ernesto G
authors.initials: EG
authors.lastname: Mata
authors.affiliation: Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , Suipacha 531, 2000 Rosario, Argentina.
authors.forename: Carina M L
authors.initials: CM
authors.lastname: Delpiccolo
mesh_terms: D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D013267:Stilbenes / Q000138:chemical synthesis*
chemical_list: D054852:Small Molecule Libraries; D013267:Stilbenes; D010165:Palladium
keywords: Heck coupling; Hiyama coupling; palladium cross-coupling reactions; solid-phase organic synthesis