title: Comparison of Pulse Rate Variability and Heart Rate Variability for Hypoglycemia Syndrome.
abstract: BACKGROUND
  Heart rate variability (HRV) is a signal obtained from RR intervals of electrocardiography (ECG) signals to evaluate the balance between the sympathetic nervous system and the parasympathetic nervous system; not only HRV but also pulse rate variability (PRV) extracted from finger pulse plethysmography (PPG) can reflect irregularities that may occur in heart rate and control procedures.
  
  
  OBJECTIVE
  The purpose of this study is to compare the HRV and PRV during hypoglycemia in order to evaluate the features that computed from PRV that can be used in detection of hypoglycemia.
  
  
  METHODS
  To this end, PRV and HRV of 10 patients who required testing with insulin-induced hypoglycemia (IIHT) in Clinics of Endocrinology and Metabolism Diseases of Bezm-i Alem University (Istanbul, Turkey), were obtained. The recordings were done at three stages: prior to IIHT, during the IIHT, and after the IIHT. We used Bland-Altman analysis for comparing the parameters and to evaluate the correlation between HRV and PRV if exists.
  
  
  RESULTS
  Significant correlation (r > 0.90, p < 0.05) and close agreement were found between HRV and PRV for mean intervals, the root-mean square of the difference of successive intervals, standard deviation of successive intervals and the ratio of the low-to-high frequency power.
  
  
  CONCLUSIONS
  In conclusion, all the features computed from PRV and HRV have close agreement and correlation according to Bland-Altman analyses' results and features computed from PRV can be used in detection of hypoglycemia.
authors.affiliation: Şükrü Okkesim, The Institute of Biomedical Engineering, Fatih University, Istanbul 34500, Turkey, E-mail: sukruokkesim@fatih.edu.tr.
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Okkesim
authors.forename: Gamze
authors.initials: G
authors.lastname: Çelik
authors.forename: Mustafa S
authors.initials: MS
authors.lastname: Yıldırım
authors.forename: Mahmut M
authors.initials: MM
authors.lastname: İlhan
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Karaman
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Taşan
authors.forename: Sadık
authors.initials: S
authors.lastname: Kara
mesh_terms: D000465:Algorithms; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology / Q000503:physiopathology*; D007328:Insulin / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011674:Pulse; D012815:Signal Processing, Computer-Assisted
chemical_list: D007328:Insulin
keywords: Insulin-induced hypoglycemia; electrocardiography; finger pulse plethysmography