title: Comparison of T2(*) mapping with diffusion-weighted imaging in the characterization of low-grade vs intermediate-grade and high-grade prostate cancer.
abstract: OBJECTIVE
  To evaluate the diagnostic value of T2(*) mapping compared with apparent diffusion coefficient (ADC) mapping in the characterization of low-grade (Gleason score, ≤6) vs intermediate-grade and high-grade (Gleason score ≥7) prostate cancer (PCa).
  
  
  METHODS
  62 patients who underwent MRI before prostatectomy were evaluated. Two readers independently scored the probabilities of tumours in 12 regions of the prostate on T2(*) and ADC images. The data were divided into two groups, i.e. low- vs intermediate- and high-grade PCa, and correlated with the histopathological results. The diagnostic performance parameters, areas under the receiver-operating characteristic curves and interreader agreements were calculated.
  
  
  RESULTS
  For Reader 2, ADC mapping exhibited a greater accuracy for intermediate-grade PCas than for high-grade PCas (0.77 vs 0.83, p < 0.05). For both readers, T2(*) mapping exhibited a greater accuracy for intermediate-grade PCas than for high-grade PCas (Reader 1, 0.86 vs 0.81; Reader 2, 0.83 vs 0.78; p < 0.05). The areas under the curve of T2(*) mappings were greater than those of the ADC mappings for the intermediate- and high-grade PCas (Reader 1, 0.83 vs 0.78; Reader 2, 0.80 vs 0.75; p < 0.05) but not for the low-grade PCas (Reader 1, 0.86 vs 0.84; Reader 2, 0.83 vs 0.82; p > 0.05). The weighted κ value of T2(*) mapping was 0.59.
  
  
  CONCLUSIONS
  T2(*) mapping improves the accuracy of the characterization of intermediate- and high-grade PCas but not low-grade PCas compared with ADC mapping.
  
  
  CONCLUSIONS
  T2(*) mapping exhibited greater diagnostic accuracy than ADC mapping in the characterization of intermediate- and high-grade PCas. T2(*) mapping exhibited limited value in the characterization of low-grade PCa.
authors.affiliation: 1 Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lian-Ming
authors.initials: LM
authors.lastname: Wu
authors.affiliation: 1 Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Zi-Zhou
authors.initials: ZZ
authors.lastname: Zhao
authors.affiliation: 1 Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Chen
authors.affiliation: 1 Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.affiliation: 1 Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Shi-Teng
authors.initials: ST
authors.lastname: Suo
authors.affiliation: 2 Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: 3 Department of Radiology, Wayne State University, Detroit, MI, USA.
authors.forename: Jiani
authors.initials: J
authors.lastname: Hu
authors.affiliation: 3 Department of Radiology, Wayne State University, Detroit, MI, USA.
authors.forename: E Mark
authors.initials: EM
authors.lastname: Haccke
authors.affiliation: 1 Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Xu
mesh_terms: D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity