title: Virginal Breast Hypertrophy: Different Presentations of 2 Cases and the Role of Tamoxifen as an Adjuvant Therapy.
abstract: BACKGROUND
  Virginal breast hypertrophy is a rapid and massive enlargement of one or both breasts. There are several proposed causes and treatment options for virginal breast hypertrophy, but the investigations to support these theories are lacking.
  
  
  METHODS
  We report two premenarchal girls with virginal breast hypertrophy who presented as different clinical cases. After their surgical interventions, their clinical courses were followed for more than 2 years with tamoxifen as an adjuvant therapy.
  
  
  CONCLUSIONS
  Breast size and shape disorders can be a disturbing cosmetic problem for adolescents who worry about their body image. A combination treatment of breast reduction surgery and tamoxifen is reasonable and can eliminate the need for repeated surgeries for girls with virginal breast hypertrophy.
authors.affiliation: Professor, Pediatric Endocrinologist, Department of Pediatric Endocrinology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey. Electronic address: gkaraguzel@ktu.edu.tr.
authors.forename: Gülay
authors.initials: G
authors.lastname: Karagüzel
authors.affiliation: Pediatrician, Department of Pediatrics, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
authors.forename: Sevcan
authors.initials: S
authors.lastname: Bilen
authors.affiliation: Professor, Department of Plastic Surgery, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Karaçal
authors.affiliation: Professor, Department of Pathology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
authors.forename: Kadriye
authors.initials: K
authors.lastname: Yıldız
authors.affiliation: Professor, Department of Plastic Surgery, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Livaoğlu
mesh_terms: D001940:Breast / Q000002:abnormalities* / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000628:therapy*; D016462:Mammaplasty; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen
keywords: Adolescent; Gigantomastia; Juvenile; Virginal breast hypertrophy