title: Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents.
abstract: BACKGROUND
  The objective of this study was to examine the cross-sectional relationship between homeostasis model assessment for insulin resistance (HOMA-IR) and serum 25-hydroxyvitamin D (25-OHD) level in Chinese children and adolescents.
  
  
  METHODS
  Anthropometric indices, lipid metabolic profile, and serum levels of glucose, insulin and 25-OHD were determined among 278 healthy prepubertal and pubertal, normal and overweight/obese children and adolescents aged 8-18 years between March 2014 and February 2015.
  
  
  RESULTS
  HOMA-IR was significantly different across vitamin D statuses (p<0.001), even after adjusting for body mass index (BMI) (p=0.035) and waist-to-height ratio (p=0.044); the difference was not significant between the vitamin D deficient and insufficient groups (p=0.120). HOMA-IR negatively correlated with serum 25-OHD level for all subjects (R2=0.148, p<0.001). Furthermore, they negatively correlated in the normal (R2=0.160, p<0.001) and overweight/obese (R2=0.086, p<0.001) groups, respectively. The regression lines of the two groups were parallel (p=0.669) but had a significantly different intercept (p<0.001). An association between HOMA-IR and BMI and serum 25-OHD level (R2=0.654, p<0.001) was demonstrated based on the stepwise multiple linear regression analysis of age, sex, pubertal maturation, BMI, waist-to-height ratio, triglyceride, cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), 25-OHD and HOMA-IR.
  
  
  CONCLUSIONS
  Our findings supported that lower vitamin D status is strongly associated with worse HOMA-IR.
authors.forename: Lingli
authors.initials: L
authors.lastname: Wang
authors.forename: Huiyan
authors.initials: H
authors.lastname: Wang
authors.forename: Huaikai
authors.initials: H
authors.lastname: Wen
authors.forename: Hongqun
authors.initials: H
authors.lastname: Tao
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhao
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood*; D002648:Child; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D009752:Nutritional Status / Q000208:ethnology; D050177:Overweight / Q000097:blood / Q000150:complications* / Q000208:ethnology / Q000378:metabolism; D063766:Pediatric Obesity / Q000097:blood / Q000150:complications* / Q000208:ethnology / Q000378:metabolism; D012720:Severity of Illness Index; D014808:Vitamin D Deficiency / Q000150:complications* / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology; D065927:Waist-Height Ratio
chemical_list: D008055:Lipids; D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol