title: Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia.
abstract: OBJECTIVE
  To investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN).
  
  
  METHODS
  WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively.
  
  
  RESULTS
  Cellular WT1 staining was 67% and vascular positivity was 73% in the EC group. In the EIN group the cellular staining was 100% and vascular staining was 85%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1-3; IQR, 1.75 vs 2, 0-3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score.
  
  
  CONCLUSIONS
  WT1 is expressed in EIN.
authors.affiliation: Department of Obstetrics and Gynecology, Bursa Cekirge Government Hospital, Bursa, Turkey.
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Atik
authors.affiliation: Department of Obstetrics and Gynecology, Uludag University, Bursa, Turkey.
authors.forename: Bilge
authors.initials: B
authors.lastname: Cetinkaya Demir
authors.affiliation: Department of Obstetrics and Gynecology, Uludag University, Bursa, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozan
authors.affiliation: Department of Pathology, Uludag University, Bursa, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Baykara
authors.affiliation: Department of Pathology, Hacettepe University, Ankara, Turkey.
authors.forename: Alp
authors.initials: A
authors.lastname: Usubutun
authors.affiliation: Department of Pathology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Yılmaz Erturk
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D018269:Carcinoma, Endometrioid / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism*; D025721:WT1 Proteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D025721:WT1 Proteins; C583751:WT1 protein, human
keywords: Wilms' tumor 1 protein; endometrial adenocarcinoma; endometrial intra-epithelial neoplasia