title: Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis.
abstract: Breast cancer is one of the most commonly occurring female malignant tumors. According to the 2012 GLOBOCAN statistics, produced by the International Agency for Research On Cancer ('IARC'), nearly 1.7 million women were diagnosed with breast cancer, with 522,000 related deaths: An increase in the incidence of breast cancer and associated mortality by nearly 18% from 2008. Metastasis is the final step in breast cancer progression, and represents the most common cause of mortality in patients with breast cancer. Therefore, a search for low-toxicity, safe and effective anti-breast cancer drugs in the form of natural compounds has become an intense focus of research. Baicalein, a widely used Chinese herbal medicine, has extensive antitumor activity. The present review briefly describes the research that has been performed on the association between baicalein and breast cancer metastasis, and further illustrates the influence of baicalein on the underlying mechanisms of breast cancer metastasis, adding a novel theory basis for baicalein antitumor research. In conclusion, baicalein may represent a promising target for the prevention and therapy of breast cancer.
authors.affiliation: Department of Oncology, The Second Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
authors.forename: Wan-Jun
authors.initials: WJ
authors.lastname: Yan
authors.affiliation: Department of Oncology, The Second Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
authors.forename: Xing-Cong
authors.initials: XC
authors.lastname: Ma
authors.affiliation: Department of Oncology, The Second Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Gao
authors.affiliation: Department of Oncology, The Second Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
authors.forename: Xing-Huan
authors.initials: XH
authors.lastname: Xue
authors.affiliation: Department of Oncology, The Second Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
authors.forename: Shu-Qun
authors.initials: SQ
authors.lastname: Zhang
keywords: EMT; SATB1; baicalein; breast cancer; invasion; metastasis