title: Aldo-keto reductase family 1 member B10 is associated with hepatitis B virus-related hepatocellular carcinoma risk.
abstract: OBJECTIVE
  Recent reports have indicated that aldo-keto reductase family 1 member B10 (AKR1B10), a cancer-related oxidoreductase, was upregulated in some chronic liver diseases. However, few studies have reported AKR1B10 expression in chronic hepatitis B virus (HBV)-infected patients. The aim of the present study was to analyze AKR1B10 expression and its relevance on hepatocellular carcinoma (HCC) development in patients with chronic HBV infection.
  
  
  METHODS
  Expression of AKR1B10 in the liver of 119 chronic HBV-infected patients was assessed and quantified immunohistochemically. A multivariate Cox model was used to estimate the hazard ratios of AKR1B10 expression for HCC development. The cumulative incidences of HCC were evaluated using Kaplan-Meier analysis.
  
  
  RESULTS
  Expression of AKR1B10 in the study cohort ranged from 0% to 84%. During the median follow-up time (6.2 years), 13 patients developed HCC. Multivariate analysis revealed that high AKR1B10 expression (≥15%) was an independent risk factor for HCC (hazard ratio, 10.8; 95% confidence interval, 3.0-38.6; P < 0.001). The 5-year cumulative incidences of HCC were 20.6% and 2.6% in patients with high and low AKR1B10 expression, respectively (P < 0.001). Patients with high AKR1B10 expression had significantly higher alanine aminotransferase levels during follow-up than those with low expression, even though antiviral treatment decreased HBV-DNA levels in both groups.
  
  
  CONCLUSIONS
  Chronic HBV-infected patients with high hepatic AKR1B10 expression had an increased risk of HCC development. This suggests that AKR1B10 upregulation might play a role in the early stages of HBV-related hepatocarcinogenesis.
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.|First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.|Department of Internal Medicine, Fujinomiya City General Hospital, Shizuoka, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Genda
authors.affiliation: Department of Hepatology, East Shonan General Hospital, Kanagawa, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ichida
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Ayato
authors.initials: A
authors.lastname: Murata
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Kamei
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Tsuzura
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Narita
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kanemitsu
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Ishikawa
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Kikuchi
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimada
authors.affiliation: Department of Hepatology, East Shonan General Hospital, Kanagawa, Japan.
authors.forename: Katsuharu
authors.initials: K
authors.lastname: Hirano
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Katsuyori
authors.initials: K
authors.lastname: Iijima
authors.affiliation: First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Pathology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Wada
authors.affiliation: Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Nagahara
authors.affiliation: Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
keywords: AKR1B10 protein; carcinoma; chronic; hepatitis b; hepatocellular; risk factors