title: Epidemiology, Pathological Characteristics and Estrogen and Progesterone Receptor Status of Operated Cases of Female Breast Cancer: A Retrospective Review of 266 Cases from Kerala.
abstract: Breast cancer is presently the most common cancer among women in Kerala, in Southern India. The objectives of this study were to analyze the epidemiology and pathological characteristics of female breast carcinoma in Kerala. 266 patients who were diagnosed with operable breast cancer between April 2009 and June 2010 were studied. Various pathological characteristics including stage, grade, axillary lymph nodal status, tumor size, and estrogen and progesterone receptor status were studied. Estrogen and progesterone receptor status were evaluated by immunohistochemistry. Chi-square test and frequency tables were used for statistical analysis. The mean age at presentation was 50 years. 48.9 % of the patients were premenopausal. 53.76 % had grade II tumors. Positive axillary lymph nodes were found in 70.3 % patients, and 68 % presented with stage II disease. 54.13 % were ER positive and 62 % were PR positive. The relatively young age at diagnosis, late presentation of the disease, and lower estrogen and progesterone receptor expression compared to patients from the West point toward the need for better breast cancer awareness and screening programmes in Kerala.
authors.affiliation: Government Medical College, Thrissur, Kerala 680596 India.
authors.forename: Ajith
authors.initials: A
authors.lastname: Vettuparambil
authors.affiliation: Government Medical College, Thrissur, Kerala 680596 India.
authors.forename: Gautham
authors.initials: G
authors.lastname: Rajan
authors.affiliation: Government Medical College, Thrissur, Kerala 680596 India.
authors.forename: Ravindran
authors.initials: R
authors.lastname: Chirukandath
authors.affiliation: Government Medical College, Thrissur, Kerala 680596 India.
authors.forename: Terence B
authors.initials: TB
authors.lastname: Culas
keywords: Age; Breast cancer; Estrogen receptor; Grade; Kerala; Lymph node; Menopause; Progesterone receptor; Stage