title: Supramolecular Drug Delivery Systems Based on Water-Soluble Pillar[n]arenes.
abstract: Supramolecular drug delivery systems (SDDSs), including various kinds of nanostructures that are assembled by reversible noncovalent interactions, have attracted considerable attention as ideal drug carriers owing to their fascinating ability to undergo dynamic switching of structure, morphology, and function in response to various external stimuli, which provides a flexible and robust platform for designing and developing functional and smart supramolecular nano-drug carriers. Pillar[n]arenes represent a new generation of macrocyclic hosts, which have unique structures and excellent properties in host-guest chemistry. This account describes recent progress in our group to develop pillararene-based stimuli-responsive supramolecular nanostructures constructed by reversible host-guest interactions for controllable anticancer drug delivery. The potential applications of these supramolecular drug carriers in cancer treatment and the fundamental questions facing SDDSs are also discussed.
authors.affiliation: Key Laboratory of Mesoscopic Chemistry of MOE Center for Multimolecular Organic Chemistry School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wu
authors.affiliation: Key Laboratory of Mesoscopic Chemistry of MOE Center for Multimolecular Organic Chemistry School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.affiliation: Key Laboratory of Mesoscopic Chemistry of MOE Center for Multimolecular Organic Chemistry School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Hu
authors.affiliation: Key Laboratory of Mesoscopic Chemistry of MOE Center for Multimolecular Organic Chemistry School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
authors.forename: Leyong
authors.initials: L
authors.lastname: Wang
mesh_terms: D000072283:A549 Cells; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D050866:Liquid Crystals / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D000644:Quaternary Ammonium Compounds; D014867:Water; D004317:Doxorubicin
keywords: drug delivery; host-guest systems; nanostructures; stimuli responsiveness; supramolecular chemistry