title: Computed tomography angiography with pulmonary artery thrombus burden and right-to-left ventricular diameter ratio after pulmonary embolism.
abstract: Purpose Computed tomography angiography is used for quantifying the significance of pulmonary embolism, but its reliability has not been well defined. Methods The study cohort comprised 10 patients randomly selected from a 150-patient prospective trial of ultrasound-facilitated fibrinolysis for acute pulmonary embolism. Four reviewers independently evaluated the right-to-left ventricular diameter ratios using the standard multiplanar reformatted technique and a simplified (axial) method, and thrombus burden with the standard modified Miller score and a new, refined Miller scoring system. Results The intraclass correlation coefficient for intra-observer variability was .949 and .970 for the multiplanar reformatted and axial methods for estimating right-to-left ventricular ratios, respectively. Inter-observer agreement was high and similar for the two methods, with intraclass correlation coefficient of .969 and .976. The modified Miller score had good intra-observer agreement (intraclass correlation coefficient .820) and was similar to the refined Miller method (intraclass correlation coefficient .883) for estimating thrombus burden. Inter-observer agreement was also comparable between the techniques, with intraclass correlation coefficient of .829 and .914 for the modified Miller and refined Miller methods. Conclusions The reliability of computed tomography angiography for pulmonary embolism was excellent for the axial and multiplanar reformatted methods for quantifying the right-to-left ventricular ratio and for the modified Miller and refined Miller scores for quantifying of pulmonary artery thrombus burden.
authors.affiliation: 1 Syntactx, LLC, New York, NY, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Ouriel
authors.affiliation: 1 Syntactx, LLC, New York, NY, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Ouriel
authors.affiliation: 1 Syntactx, LLC, New York, NY, USA.
authors.forename: Yeun J
authors.initials: YJ
authors.lastname: Lim
authors.affiliation: 2 Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Piazza
authors.affiliation: 2 Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Samuel Z
authors.initials: SZ
authors.lastname: Goldhaber
mesh_terms: D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging*; D015331:Cohort Studies; D000072226:Computed Tomography Angiography; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D015588:Observer Variation; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000000981:diagnostic imaging*; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013927:Thrombosis / Q000000981:diagnostic imaging*
keywords: Miller Score; Pulmonary embolism; computed tomography pulmonary angiography; reliability; right-to-left ventricular ratio