title: [Incidence and risk factors of HIV infection among sero-negative spouses of people living with HIV/AIDS in Dehong prefecture, Yunnan province].
abstract: OBJECTIVE
  To study the incidence rate and risk factors of HIV infection among sero-negative spouses of people living with HIV/AIDS (HIV/AIDS) in Dehong prefecture, Yunnan province.
  
  
  METHODS
  A prospective cohort study was conducted from February 2009 to December 2014 in Dehong prefecture, Yunnan province. Questionnaire survey and HIV related tests were carried out once a year.
  
  
  RESULTS
  By the end of December 2014, 2 091 sero-negative spouses had been recruited, of whom 1 692 were followed-up for at least one time. RESULTS showed that 34 new HIV infections were identified within 5 494.52 person years of follow-up, for an overall incidence of 0.62 per 100 person years. HIV incidence rates appeared as 0.79 per 100 person years, 0.62 per 100 person years, 0.47 per 100 person years in 2009-2010, 2011-2012, 2013-2014, respectively. Data from the Cox proportional hazard regression model indicated that risk factors of HIV infection among sero-negative spouses of HIV/AIDS were: non-consistent condom use (HR=4.64, 95%CI: 1.89-11.40,P= 0.001), HIV/AIDS delayed antiviral retrovirus therapy (ART) for more than one year (HR=3.70, 95% CI: 1.44-9.49,P=0.007) after the HIV negative spouses were initially recruited, HIV/AIDS did not receive any ART (HR=3.62, 95% CI: 1.14-11.51,P=0.029).
  
  
  CONCLUSIONS
  The incidence of HIV infection among sero-negative spouses in Dehong prefecture was relatively low. Publicity on consistent condom use program should be emphasized among sero-negative spouses of HIV/AIDS, together with the timely provision of ART to those HIV/AIDS.
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Yuecheng
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Renhai
authors.initials: R
authors.lastname: Tang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Shijiang
authors.initials: S
authors.lastname: Yang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Shitan
authors.initials: S
authors.lastname: Yao
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Runhua
authors.initials: R
authors.lastname: Ye
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Jibao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.
authors.forename: Song
authors.initials: S
authors.lastname: Duan
authors.affiliation: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China.
authors.forename: Na
authors.initials: N
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D018023:HIV Seronegativity; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012725:Sexual Behavior; D018454:Spouses; D011795:Surveys and Questionnaires; D055815:Young Adult