title: Atypical language representation in children with intractable temporal lobe epilepsy.
abstract: This study evaluated language organization in children with intractable epilepsy caused by temporal lobe focal cortical dysplasia (FCD) alone or dual pathology (temporal lobe FCD and hippocampal sclerosis, HS). We analyzed clinical, neurological, fMRI, neuropsychological, and histopathologic data in 46 pediatric patients with temporal lobe lesions who underwent excisional epilepsy surgery. The frequency of atypical language representation was similar in both groups, but children with dual pathology were more likely to be left-handed. Atypical receptive language cortex correlated with lower intellectual capacity, verbal abstract conceptualization, receptive language abilities, verbal working memory, and a history of status epilepticus but did not correlate with higher seizure frequency or early seizure onset. Histopathologic substrate had only a minor influence on neuropsychological status. Greater verbal comprehension deficits were noted in children with atypical receptive language representation, a risk factor for cognitive morbidity.
authors.affiliation: Charles University, Faculty of Arts, Department of Psychology, Prague, Czech Republic; Motol University Hospital, Prague, Czech Republic.
authors.forename: Alice
authors.initials: A
authors.lastname: Maulisova
authors.affiliation: Brain Institute, Nicklaus Children's Hospital, Miami, FL, United States. Electronic address: brandon.korman@mch.com.
authors.forename: Brandon
authors.initials: B
authors.lastname: Korman
authors.affiliation: Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Rey
authors.affiliation: Department of Radiology, Nicklaus Children's Hospital, Miami, FL, United States.
authors.forename: Byron
authors.initials: B
authors.lastname: Bernal
authors.affiliation: Brain Institute, Nicklaus Children's Hospital, Miami, FL, United States; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Duchowny
authors.affiliation: Charles University, Faculty of Arts, Department of Psychology, Prague, Czech Republic.
authors.forename: Marketa
authors.initials: M
authors.lastname: Niederlova
authors.affiliation: Charles University, 2nd Faculty of Medicine, Prague, Czech Republic; Motol University Hospital, Prague, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Krsek
authors.affiliation: University of Ostrava, Faculty of Medicine, Ostrava, Czech Republic; Faculty Hospital Ostrava, Ostrava, Czech Republic.
authors.forename: Vilem
authors.initials: V
authors.lastname: Novak
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D000069279:Drug Resistant Epilepsy / Q000000981:diagnostic imaging* / Q000523:psychology / Q000601:surgery; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000523:psychology / Q000601:surgery; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000502:physiology / Q000601:surgery; D055815:Young Adult
keywords: Cognition; FCD; Handedness; Hippocampal sclerosis; Histopathology; Status epilepticus; Temporal lobe epilepsy