title: Radical Cyclizations for the Synthesis of Pyrroloindoles: Progress toward the Flinderoles.
abstract: Under the influence of Lewis acid catalysis, donor/acceptor cyclopropanes underwent nucleophilic ring opening by indolines. The resulting N-alkyl indolines bearing a pendant malonyl moiety oxidatively cyclized to 1,2-pyrroloindoles. This method was showcased by the preparation of the skeletal structure of the flinderoles.
authors.affiliation: Department of Chemistry, The University of Western Ontario , London, Ontario, Canada , N6A 5B7.
authors.forename: Joanne E Curiel
authors.initials: JE
authors.lastname: Tejeda
authors.affiliation: Department of Chemistry, The University of Western Ontario , London, Ontario, Canada , N6A 5B7.
authors.forename: Bryan K
authors.initials: BK
authors.lastname: Landschoot
authors.affiliation: Department of Chemistry, The University of Western Ontario , London, Ontario, Canada , N6A 5B7.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kerr