title: Contrast Induced Nephropathy with Intravenous Iodinated Contrast Media in Routine Diagnostic Imaging: An Initial Experience in a Tertiary Care Hospital.
abstract: Background. Contrast induced nephropathy (CIN) is common cause of hospital acquired renal failure, defined as iatrogenic deterioration of renal function following intravascular contrast administration in the absence of another nephrotoxic event. Objectives. Objectives were to calculate incidence of CIN with routine IV contrast usage and to identify its risk factors. Materials and Methods. Study was conducted on 250 patients (having eGFR ≥ 45 mL/min/1.73 m(2)) receiving intravenous contrast. Various clinical risk factors and details of contrast media were recorded. Patients showing 25% increase in postprocedural serum creatinine value or an absolute increase of 0.5 mg/dL (44.2 mmol/L) were diagnosed as having CIN. Results and Conclusions. Postprocedural serum creatinine showed significant increase from baseline levels. 25 patients (10%) developed CIN. CIN was transient in 21 (84%) patients developing CIN. One patient (4%) developed renal failure and another died due to unknown cause. Dehydration, preexisting renal disease, cardiac failure, previous contrast administration, and volume of contrast had significant correlation with development of CIN (p < 0.05); whereas demographic variables, baseline serum creatinine/eGFR, previous renal surgery, diabetes mellitus, hypertension, nephrotoxic drug intake, abnormal routine hematology, and contrast characteristics had no correlation with CIN. CIN is a matter of concern even in routine imaging requiring intravenous contrast media, in our set-up.
authors.affiliation: Department of Radiodiagnosis, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Shuchi
authors.initials: S
authors.lastname: Bhatt
authors.affiliation: Department of Radiodiagnosis, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Nipun
authors.initials: N
authors.lastname: Rajpal
authors.affiliation: Department of Radiodiagnosis, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Vineeta
authors.initials: V
authors.lastname: Rathi
authors.affiliation: Department of Medicine, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Rajneesh
authors.initials: R
authors.lastname: Avasthi