title: A Primer on Health Economic Evaluations in Thoracic Oncology.
abstract: There is growing interest for economic evaluation in oncology to illustrate the value of multiple new diagnostic and therapeutic interventions. As these analyses have started to move from specialist publications into mainstream medical literature, the wider medical audience consuming this information may need additional education to evaluate it appropriately. Here we review standard practices in economic evaluation, illustrating the different methods with thoracic oncology examples where possible. When interpreting and conducting health economic studies, it is important to appraise the method, perspective, time horizon, modeling technique, discount rate, and sensitivity analysis. Guidance on how to do this is provided. To provide a method to evaluate this literature, a literature search was conducted in spring 2015 to identify economic evaluations published in the Journal of Thoracic Oncology. Articles were reviewed for their study design, and areas for improvement were noted. Suggested improvements include using more rigorous sensitivity analyses, adopting a standard approach to reporting results, and conducting complete economic evaluations. Researchers should design high-quality studies to ensure the validity of the results, and consumers of this research should interpret these studies critically on the basis of a full understanding of the methodologies used before considering any of the conclusions. As advancements occur on both the research and consumer sides, this literature can be further developed to promote the best use of resources for this field.
authors.affiliation: Department of Health Systems, Management and Policy, University of Colorado Anschutz Medical Campus, University of Colorado, Aurora, Colorado. Electronic address: Melanie.Whittington@UCDenver.edu.
authors.forename: Melanie D
authors.initials: MD
authors.lastname: Whittington
authors.affiliation: Department of Health Systems, Management and Policy, University of Colorado Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Atherly
authors.affiliation: Department of Pathology, University of Colorado School of Medicine, University of Colorado, Aurora, Colorado.
authors.forename: Gregary T
authors.initials: GT
authors.lastname: Bocsi
authors.affiliation: School of Medicine, University of Colorado Anschutz Medical Campus, University of Colorado Aurora, Colorado.
authors.forename: D Ross
authors.initials: DR
authors.lastname: Camidge
mesh_terms: D003362:Cost-Benefit Analysis; D003663:Decision Trees; D006801:Humans; D008390:Markov Chains; D008495:Medical Oncology / Q000191:economics*; D010506:Periodicals as Topic / Q000191:economics; D019057:Quality-Adjusted Life Years; D012107:Research Design; D013899:Thoracic Neoplasms / Q000191:economics*
keywords: Cost-benefit analysis; Cost-effectiveness analysis; Cost-utility analysis; Economic evaluation