title: Blood-Brain Barrier Breakdown Determines Differential Therapeutic Outcome in Genetically Diverse Forms of Medulloblastoma.
abstract: Medulloblastoma driven by Wnt/β-catenin and Sonic hedgehog pathway mutations show favorable and poor patient survival upon treatment, respectively. In this Cancer Cell issue, Phoenix and colleagues (2016) report disruption of the blood-brain barrier by Wif1 specifically in Wnt-driven medulloblastoma, resulting in increased treatment response and survival in mouse models.
authors.affiliation: Institute of Neurology (Edinger-Institute), Johann Wolfgang Goethe-University Frankfurt Medical School, Heinrich-Hoffmann-Straße 7, 60528 Frankfurt, Germany.
authors.forename: Sylvaine
authors.initials: S
authors.lastname: Guerit
authors.affiliation: Institute of Neurology (Edinger-Institute), Johann Wolfgang Goethe-University Frankfurt Medical School, Heinrich-Hoffmann-Straße 7, 60528 Frankfurt, Germany. Electronic address: stefan.liebner@kgu.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Liebner
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002528:Cerebellar Neoplasms / Q000188:drug therapy; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy*; D015398:Signal Transduction; D051176:beta Catenin / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D051176:beta Catenin