title: Preparation of a new Fe3O4/starch-g-polyester nanocomposite hydrogel and a study on swelling and drug delivery properties.
abstract: A new Fe3O4/starch-g-poly(ethylene phthalate) hydrogel nanocomposite was prepared using poly(ethylene phthalate) grafted onto starch as a biopolymer. The nanocomposite was characterized by FT-IR, XRD, DLS and SEM. FT-IR spectra proved that polyester had been grafted onto starch in a copolymerization reaction. XRD spectra confirmed the synthesis of the nanocomposite and the average size of the particles. SEM observations showed that Fe3O4 nanoparticles have been uniformly dispersed in a polymeric matrix. Swelling and drug delivery properties of Fe3O4/starch-g-poly(ethylene phthalate) nanocomposite were studied. It was confirmed that Fe3O4/starch-g-polyester nanocomposite with 0.01M concentrations of FeCl2 and 0.005M of FeCl3 is the most appropriate for swelling and the composite without Fe3O4 nanoparticles is optimum for drug delivery.
authors.affiliation: Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran. Electronic address: h_hamidian@pnu.ac.ir.
authors.forename: Hooshang
authors.initials: H
authors.lastname: Hamidian
authors.affiliation: Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran.
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Tavakoli
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D000067493:Dynamic Light Scattering; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D060328:Magnetic Phenomena; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D010756:Phosphoric Acids / Q000737:chemistry; D010795:Phthalic Acids / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry*; D017973:Tungsten Compounds / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: C519880:12-tungstophosphoric acid; D004337:Drug Carriers; D020100:Hydrogels; D010756:Phosphoric Acids; D010795:Phthalic Acids; D011091:Polyesters; D017973:Tungsten Compounds; D013213:Starch; D052203:Ferrosoferric Oxide
keywords: Drug delivery; Heteropolyacid; Nanocomposite; Polyester; Starch; Swelling