title: Apelin/APJ system and cancer.
abstract: Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G protein-coupled receptor. Apelin/APJ system has a wide tissue distribution in the brain as well as in peripheral organs including heart, lung, vessels, and adipose tissue. Apelin/APJ was involved in regulating cardiac and vascular function, heart development, and vascular smooth muscle cell proliferation. In this article, we summarize the role of apelin/APJ system on lung cancer, gastroesophageal and colonic cancer, hepatocellular carcinoma, prostate cancer, endometrial cancer, oral squamous cell carcinoma, brain cancer, and tumor neoangiogenesis. Apelin/APJ may be a potential anticancer therapeutic target.
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Yang
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China. Electronic address: shuangyulv@henu.edu.cn.
authors.forename: Shuang-Yu
authors.initials: SY
authors.lastname: Lv
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Ye
authors.affiliation: Department of Physiology, Medical College of Shihezi University, Shihezi, Xinjiang 832000, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000073861:Apelin; D000075244:Apelin Receptors; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D009369:Neoplasms / Q000098:blood supply / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*
chemical_list: C115436:APLN protein, human; C104575:APLNR protein, human; D000073861:Apelin; D000075244:Apelin Receptors; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled
keywords: APJ; Apelin; Cancer; Carcinoma; Vessels