title: Glioblastoma in the Canton of Zurich, Switzerland revisited: 2005 to 2009.
abstract: BACKGROUND
  A population-based analysis of patients with glioma diagnosed between 1980 and 1994 in the Canton of Zurich in Switzerland confirmed the overall poor prognosis of glioblastoma. To explore changes in outcome, registry data were reevaluated for patients diagnosed between 2005 and 2009.
  
  
  METHODS
  Patients with glioblastoma who were diagnosed between 2005 and 2009 were identified by the Zurich and Zug Cancer Registry. The prognostic significance of epidemiological and clinical data, isocitrate dehydrogenase 1 (IDH1)(R132H) mutation status, and O6 methylguanine DNA methyltransferase (MGMT) promoter methylation status was analyzed using the Kaplan-Meier method and the Cox proportional hazards model.
  
  
  RESULTS
  A total of 264 patients with glioblastoma were identified, for an annual incidence of 3.9 compared with the previous incidence of 3.7. The mean age of the patients at the time of diagnosis was 59.5 years in the current cohort compared with 61.3 years previously. The overall survival (OS) rate was 46.4% at 1 year, 22.5% at 2 years, and 14.4% at 3 years in the current study compared with 17.7% at 1 year, 3.3% at 2 years, and 1.2% at 3 years as reported previously. The median OS for all patients with glioblastoma was 11.5 months compared with 4.9 months in the former patient population. The median OS was 1.9 months for best supportive care, 6.2 months for radiotherapy alone, 6.7 months for temozolomide alone, and 17.0 months for radiotherapy plus temozolomide. Multivariate analysis revealed age, Karnofsky performance score, extent of tumor resection, first-line treatment, year of diagnosis, and MGMT promoter methylation status were associated with survival in patients with IDH1(R132H) -nonmutant glioblastoma.
  
  
  CONCLUSIONS
  The OS of patients newly diagnosed with glioblastoma in the Canton of Zurich in Switzerland markedly improved from 1980 through 1994 to 2005 through 2009. Cancer 2016;122:2206-15. © 2016 American Cancer Society.
authors.affiliation: Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Gramatzki
authors.affiliation: Zurich and Zug Cancer Registry, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Dehler
authors.affiliation: Department of Neuropathology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Elisabeth Jane
authors.initials: EJ
authors.lastname: Rushing
authors.affiliation: Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Zaugg
authors.affiliation: Department of Oncology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Hofer
authors.affiliation: Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yonekawa
authors.affiliation: Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Helmut
authors.initials: H
authors.lastname: Bertalanffy
authors.affiliation: Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Anton
authors.initials: A
authors.lastname: Valavanis
authors.affiliation: Zurich and Zug Cancer Registry, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Korol
authors.affiliation: Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
authors.forename: Sabine
authors.initials: S
authors.lastname: Rohrmann
authors.affiliation: Department of Oncology, Kantonsspital Winterthur, Winterthur, Switzerland.
authors.forename: Miklos
authors.initials: M
authors.lastname: Pless
authors.affiliation: Department of Neurosurgery, Kantonsspital Winterthur, Winterthur, Switzerland.
authors.forename: Joachim
authors.initials: J
authors.lastname: Oberle
authors.affiliation: Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Roth
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ohgaki
authors.affiliation: Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Weller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019175:DNA Methylation; D005260:Female; D005909:Glioblastoma / Q000453:epidemiology* / Q000209:etiology / Q000266:history / Q000401:mortality; D049674:History, 21st Century; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics; D011379:Prognosis; D011401:Promoter Regions, Genetic; D016016:Proportional Hazards Models; D012042:Registries; D013557:Switzerland / Q000453:epidemiology; D055815:Young Adult
chemical_list: D019853:O(6)-Methylguanine-DNA Methyltransferase
keywords: O6 methylguanine DNA methyltransferase (MGMT); epidemiological study; glioblastoma; isocitrate dehydrogenase 1 (IDH1); survival; temozolomide