title: Genetic risk of TNFSF4 and FAM167A-BLK polymorphisms in children with asthma and allergic rhinitis in a Han Chinese population.
abstract: Asthma and allergic rhinitis (AR) frequently occur as comorbid diseases of the upper airways. Single-nucleotide polymorphisms (SNPs) in the TNFSF4 and FAM167A-BLK genes have recently been shown to be associated with various immune-related disorders.
  
  
  
  Our aim was to determine whether TNFSF4 or FAM167A-BLK polymorphisms confer genetic susceptibility to asthma and AR in a Han Chinese population.
  
  
  
  We performed a case-control study of 290 asthmatic children and 252 healthy controls. Nine SNPs in the TNFSF4 region (rs1234313, rs1234314, rs1234315, rsl 2039904, rs844648 and rsl 0912580) and the FAM167A-BLK region (rs2254546, rs13277113 and rs1600249) were detected using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
  
  
  
  This study revealed that three SNPs in TNFSF4 (rsl 234313, rsl 234314 and rsl 234315) and two SNPs in FAM167A-BLK (rs2254546 and rsl 600249) were significantly correlated with asthma and AR, while SNP rsl600249 was associated with asthma without allergic rhinitis as a risk factor. Further, we demonstrated synergistic effects between the TNFSF4 and FAM167A-BLK SNPs.
  
  
  
  This study supports that the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and AR gene risk in the Han Chinese cohort.
authors.affiliation: a Department of Otorhinolaryngology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Otorhinolaryngology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ke
authors.affiliation: a Department of Otorhinolaryngology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , People's Republic of China.
authors.forename: Hou-Yong
authors.initials: HY
authors.lastname: Kang
authors.affiliation: a Department of Otorhinolaryngology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , People's Republic of China.
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: a Department of Otorhinolaryngology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: a Department of Otorhinolaryngology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , People's Republic of China.
authors.forename: Su-Ling
authors.initials: SL
authors.lastname: Hong
mesh_terms: D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004843:Epistasis, Genetic; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D053278:OX40 Ligand / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D065631:Rhinitis, Allergic / Q000209:etiology / Q000235:genetics*; D012306:Risk; D064267:Intrinsically Disordered Proteins
chemical_list: D053278:OX40 Ligand; D011506:Proteins; C584607:FAM167A protein, human; D064267:Intrinsically Disordered Proteins; C089251:TNFSF4 protein, human
keywords: Allergic rhinitis; FAM167A-BLK; TNFSF4; asthma; polymorphisms