title: Protective effect of oleanolic acid on oxidative injury and cellular abnormalities in doxorubicin induced cardiac toxicity in rats.
abstract: The prevention of doxorubicin (Dox) induced cardiotoxicity may be co-operative to recover future Dox treatment. The aim of this study was to explore the cardioprotective effects of oleanolic acid (OA), an antioxidant agent, on Dox induced cardiotoxicity. OA is a triterpenoid compound, which exist widely in plant kingdom in free acid form or as a glycosidic triterpenoids saponins. Cardiotoxicity was induced in Wistar rats with single intravenous injection of doxorubicin at dose of 67.75 mg/kg i.v for 48 hrs. At 12 hrs of interval following Dox administration the cardioprotective effect of OA (1.5 mg/kg, i.v.) and Amifostine (AMF) (90 mg/kg i.v., single dose prior 30 min) were evaluated. Induction of cardiotoxicity was confirmed by increase in systolic, diastolic, mean arterial pressures, maximal positive rate of developed left ventricular pressure (+LVdP/dtmax, an indicator of myocardial contraction), maximal negative rate of developed left ventricular pressure (-LVdP/dtmax, a meter of myocardial relaxation) and an increase in left ventricular end-diastolic pressure (LVEDP, a marker of pre-load). Cardiac markers in such as CK-MB, LDH and alterations in ECG. Dox administration showed alteration in Biochemical parameters and endogenous antioxidants. Administration of OA Showed maximal protection against Dox induced cardiac toxicity as observed by reduction in blood pressure, prevention of left ventricular function and attenuation of biochemical and antioxidant parameters. Based on the findings, its concluded that OA can be used as an adjuvant with Dox therapy in treating cancers.
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Division, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Sameer N
authors.initials: SN
authors.lastname: Goyal
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Division, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Umesh B
authors.initials: UB
authors.lastname: Mahajan
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Division, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Govind
authors.initials: G
authors.lastname: Chandrayan
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Division, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Vivek S
authors.initials: VS
authors.lastname: Kumawat
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Division, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Sarika
authors.initials: S
authors.lastname: Kamble
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Division, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Pradip
authors.initials: P
authors.lastname: Patil
authors.affiliation: Department of Pharmaceutics and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Yogeeta O
authors.initials: YO
authors.lastname: Agrawal
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Division, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur- Dist-Dhule, Maharashtra, India.
authors.forename: Chandragouda R
authors.initials: CR
authors.lastname: Patil
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University Al-Ain, United Arab Emirates.
authors.forename: Shreesh
authors.initials: S
authors.lastname: Ojha
keywords: Doxorubicin; antioxidant; cardiotoxicity; lipid peroxidation; oleanolic acid