title: [ROLE OF KINETIC PERFORMANCE OF PSA IN SELECTION OF THE PATIENTS FOR CONDUCTION OF 11C-CHOLINE PET/CT AIMED TO REVEAL LOCAL RECURRENCES OF PROSTATE CANCER].
abstract: Given study was aimed to research a role of kinetic performance of PSA in selection of the patients for conduction 11C-choline PET/CT in order to reveal local recurrences in patient with prostate cancer after radiation therapy (RT) and radical prostatectomy (RP). The study included 185 patients with histologically distinctive prostate cancer and biochemical signs of tumor recurrence after RP (61 patients) or RT (124 patients). All the patients were examined using 11C-choline PET/CT in order to detect local relapses. Calculation of growth rate of the PSA level and PSA doubling time were made. According to results of 11C-choline PET/CT, recurrences of prostate cancer were detected in 124 out of 185 (65%). There were 22 patients out of 61 (36%) after RP and there were 102 patients out of 124 (82%) after RT. It was stated a correlation between PSA rates, growth rate of PSA level and presence or absence of relapse according to PET/CT results. PSA level and growth rate of PSA were indicated as the most significant predictive signs, which could influence on the selection of the patients for conduction of 11C-choline PET/CT in relation to detection of local recurrence after RT and RP.
authors.forename: M A
authors.initials: MA
authors.lastname: Rybalov
authors.forename: I Ya
authors.initials: IY
authors.lastname: De Iong
authors.forename: A I
authors.initials: AI
authors.lastname: Breusma
authors.forename: S Kh
authors.initials: SKh
authors.lastname: Al'-Shukri
authors.forename: S Yu
authors.initials: SY
authors.lastname: Borovets
mesh_terms: D000368:Aged; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D002794:Choline / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D011468:Prostatectomy / Q000009:adverse effects / Q000379:methods; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D002794:Choline