title: Neurotrophic factors and their inhibitors in chronic pain treatment.
abstract: Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.
authors.affiliation: Neurorestoration group, King's College London, London, UK. Electronic address: jayne.kelleher@kcl.ac.uk.
authors.forename: Jayne H
authors.initials: JH
authors.lastname: Kelleher
authors.affiliation: Neurorestoration group, King's College London, London, UK.
authors.forename: Damini
authors.initials: D
authors.lastname: Tewari
authors.affiliation: Neurorestoration group, King's College London, London, UK.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: McMahon
mesh_terms: D000818:Animals; D059350:Chronic Pain / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D020932:Nerve Growth Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000093242:Interleukin-6 Inhibitors
chemical_list: D015850:Interleukin-6; D020932:Nerve Growth Factor; D000093242:Interleukin-6 Inhibitors
keywords: Clinical trial; IL6; NGF; Pain