title: Universal decolonization with hypochlorous solution in a burn intensive care unit in a tertiary care community hospital.
abstract: Infections are the leading cause of morbidity and mortality in burn patients. Patients colonized with methicillin-resistant Staphylococcus aureus (MRSA) are at higher risk of developing an invasive infection, and MRSA is endemic in many burn units. The typical decolonization regimen of mupirocin and chlorhexidine bathing is not optimal in burn patients because of chlorhexidine limitations on nonintact skin. We studied the impact of universal decolonization using mupirocin and hypochlorous acid bathing on health care-associated MRSA infections in a burn intensive care unit. We show a significant decrease in total MRSA infections.
authors.affiliation: Department of Infection Prevention and Control, Maricopa Integrated Health System, Phoenix, AZ.
authors.forename: Dorinne
authors.initials: D
authors.lastname: Gray
authors.affiliation: The Arizona Burn Center, Maricopa Integrated Health System, Phoenix, AZ.
authors.forename: Kevin
authors.initials: K
authors.lastname: Foster
authors.affiliation: Department of Infection Prevention and Control, Maricopa Integrated Health System, Phoenix, AZ.
authors.forename: Abner
authors.initials: A
authors.lastname: Cruz
authors.affiliation: Department of Infection Prevention and Control, Maricopa Integrated Health System, Phoenix, AZ.
authors.forename: Gail
authors.initials: G
authors.lastname: Kane
authors.affiliation: Department of Infection Prevention and Control, Maricopa Integrated Health System, Phoenix, AZ.
authors.forename: Mike
authors.initials: M
authors.lastname: Toomey
authors.affiliation: Biostatistics, A.T. Still University, Mesa, AZ.
authors.forename: Curtis
authors.initials: C
authors.lastname: Bay
authors.affiliation: The Arizona Burn Center, Maricopa Integrated Health System, Phoenix, AZ.
authors.forename: Patricia
authors.initials: P
authors.lastname: Kardos
authors.affiliation: Department of Infection Prevention and Control, Maricopa Integrated Health System, Phoenix, AZ. Electronic address: Amin_Ostovar@dmgaz.org.
authors.forename: Gholamabbas Amin
authors.initials: GA
authors.lastname: Ostovar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000985:Antisepsis / Q000379:methods*; D001494:Baths / Q000379:methods*; D002053:Burn Units; D002056:Burns / Q000150:complications*; D002353:Carrier State / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006764:Hospitals, Community; D006801:Humans; D006997:Hypochlorous Acid / Q000627:therapeutic use*; D007223:Infant; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus; D063128:Tertiary Health Care; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D006997:Hypochlorous Acid
keywords: Universal decolonization; hypochlorous acid; methicillin-resistant S aureus decolonization; methicillin-resistant Staphylococcus aureus infection