title: Ca2+ dialogue between acidic vesicles and ER.
abstract: Extracellular stimuli evoke the synthesis of intracellular second messengers, several of which couple to the release of Ca(2+)from Ca(2+)-storing organelles via activation of cognate organellar Ca(2+)-channel complexes. The archetype is the inositol 1,4,5-trisphosphate (IP3) and IP3receptor (IP3R) on the endoplasmic reticulum (ER). A less understood, parallel Ca(2+)signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca(2+)release from acidic Ca(2+)stores [e.g. endo-lysosomes, secretory vesicles, lysosome-related organelles (LROs)]. NAADP-induced Ca(2+)release absolutely requires organellar TPCs (two-pore channels). This review discusses how ER and acidic Ca(2+)stores physically and functionally interact to generate and shape global and local Ca(2+)signals, with particular emphasis on the two-way dialogue between these two organelles.
authors.affiliation: Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K. Anthony.morgan@pharm.ox.ac.uk.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Morgan
mesh_terms: D000143:Acids; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D015388:Organelles / Q000378:metabolism
chemical_list: D000143:Acids; D002118:Calcium
keywords: Ca2+; IP3; Lysosome; NAADP; TPC; endoplasmic reticulum