title: Copper-catalyzed alkylarylation of activated alkenes using isocyanides as the alkyl source: an efficient radical access to 3,3-dialkylated oxindoles.
abstract: A novel and efficient protocol for the synthesis of 3,3-dialkylated oxindoles is described. The method involves a copper-catalyzed tandem radical addition/cyclization of N-arylacrylamides with the alkyl radicals generated from isocyanides. Two C-C bonds are formed in a single step.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium. nsharma023@gmail.com erik.vandereycken@chem.kuleuven.be.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Li
authors.forename: Upendra K
authors.initials: UK
authors.lastname: Sharma
authors.forename: Nandini
authors.initials: N
authors.lastname: Sharma
authors.forename: Gonghua
authors.initials: G
authors.lastname: Song
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken