title: Computational micro-scale model of control of extravascular water and capillary perfusion in the air blood barrier.
abstract: A computational model of a morphologically-based alveolar capillary unit (ACU) in the rabbit is developed to relate lung fluid balance to mechanical forces between capillary surface and interstitium during development of interstitial edema. We hypothesize that positive values of interstitial liquid pressure Pliq impact on capillary transmural pressure and on blood flow. ACU blood flow, capillary recruitment and filtration are computed by modulating vascular and interstitial pressures. Model results are compared with experimental data of Pliq increasing from ~-10 (control) up to ~4cmH2O in two conditions, hypoxia and collagenase injection. For hypoxia exposure, fitting data requires a linear increase in hydraulic conductivity Lp and capillary pressure PC, that fulfils the need of increase in oxygen delivery. For severe fragmentation of capillary endothelial barrier (collagenase injection), fitting requires a rapid increase in both hydraulic and protein permeability, causing ACU de-recruitment, followed by an increase in PC as a late response to restore blood flow. In conclusion, the model allows to describe the lung adaptive response to edemagenic perturbations; the increase in Pliq, related to the low interstitial compliance, provides an efficient control of extravascular water, by limiting microvascular filtration.
authors.affiliation: Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Mazzuca
authors.affiliation: Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy. Electronic address: andrea.aliverti@polimi.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Aliverti
authors.affiliation: Dipartimento di Medicina Sperimentale, University di Milano-Bicocca, Monza, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Miserocchi
mesh_terms: D000465:Algorithms; D000818:Animals; D015824:Blood-Air Barrier / Q000378:metabolism* / Q000503:physiopathology; D002196:Capillaries / Q000378:metabolism* / Q000503:physiopathology; D002199:Capillary Permeability; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008168:Lung / Q000098:blood supply* / Q000503:physiopathology; D008955:Models, Cardiovascular; D010477:Perfusion; D011312:Pressure; D011654:Pulmonary Edema / Q000378:metabolism / Q000503:physiopathology; D011817:Rabbits; D015203:Reproducibility of Results; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water
keywords: Hydrostatic pulmonary edema; Lung interstitial edema; Starling resistor; permeability-related pulmonary edema