title: Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Patients with Neuroendocrine Tumors: An Izmir Oncology Group Study.
abstract: BACKGROUND
  Several studies evaluating the prognostic factors of gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) have been published. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been accepted as prognostic factors for cancer patients.
  
  
  METHODS
  This study included 132 patients diagnosed with GEP-NETs. Peripheral blood samples were collected before the pretreatment period.
  
  
  RESULTS
  NLR and PLR were increased as the grade increased in NETs. The embryonic origin analysis revealed higher NLR and PLR rates in NETs of foregut origin. NLR and PLR were also higher in pancreatic NET patients compared to the gastroenteric NET patients. Analysis of NETs by TNM indicated that an advanced stage was accompanied by significantly higher NLR and PLR. We found a strong negative correlation between progression-free survival and NLR and PLR.
  
  
  CONCLUSIONS
  The study verified that NLR and PLR are simple laboratory findings that can be used to identify NETs with a worse outcome.
authors.forename: Tarik
authors.initials: T
authors.lastname: Salman
authors.forename: Seher Nazli
authors.initials: SN
authors.lastname: Kazaz
authors.forename: Umut
authors.initials: U
authors.lastname: Varol
authors.forename: Utku
authors.initials: U
authors.lastname: Oflazoglu
authors.forename: Ilkay Tugba
authors.initials: IT
authors.lastname: Unek
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kucukzeybek
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alacacioglu
authors.forename: Elif
authors.initials: E
authors.lastname: Atag
authors.forename: Huseyin Salih
authors.initials: HS
authors.lastname: Semiz
authors.forename: Hakan
authors.initials: H
authors.lastname: Cengiz
authors.forename: Ilhan
authors.initials: I
authors.lastname: Oztop
authors.forename: Mustafa Oktay
authors.initials: MO
authors.lastname: Tarhan
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001772:Blood Cell Count; D001792:Blood Platelets / Q000166:cytology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000097:blood* / Q000175:diagnosis; D009504:Neutrophils / Q000166:cytology*; D011379:Prognosis; D012372:ROC Curve; D012737:Sex Factors