title: Validity of breast-specific gamma imaging for Breast Imaging Reporting and Data System 4 lesions on mammography and/or ultrasound.
abstract: OBJECTIVE
  The purpose of this study was to assess the breast-specific gamma imaging (BSGI) in Breast Imaging Reporting and Data System (BI-RADS) 4 lesions on mammography and/or ultrasound.
  
  
  METHODS
  We performed a retrospective review of 162 patients who underwent BSGI in BI-RADS 4 lesions on mammography and/or ultrasound.
  
  
  RESULTS
  Of the 162 breast lesions, 66 were malignant tumors and 96 were benign tumors. Sensitivity and specificity of BSGI were 90.9% and 78.1%, and positive predictive value and negative predictive value were 74.1% and 92.6%. The sensitivity or specificity of mammography and ultrasound were 74.2% and 56.3% and 87.9% and 19.8%, respectively. The sensitivity and specificity of BSGI for breast lesions ≤1 cm were 88.0% and 86.8%, while the values of beast lesions >1 cm were 92.7% and 61.5%. The sensitivity or specificity of BSGI and mammography for patients with dense breasts were 92.0% and 81.3% and 72.0% and 50.0%, respectively. 26 patients showed neither a nodule nor microcalcification on ultrasound, but showed suspicious calcification on mammography. The sensitivity and specificity of BSGI with microcalcification only lesion were 75.0% and 94.4%.
  
  
  CONCLUSIONS
  This study demonstrated that BSGI had shown high sensitivity and specificity, as well as positive and negative predictive values in BI-RADS 4 lesions on ultrasound and/or mammography. BSGI showed excellent results in dense breasts, in lesions that are less than 1 cm in size and lesions with suspicious microcalcification only.
authors.affiliation: Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Min Jeng
authors.initials: MJ
authors.lastname: Cho
authors.affiliation: Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Yang
authors.affiliation: Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Yeong Beom
authors.initials: YB
authors.lastname: Yu
authors.affiliation: Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Kyoung Sik
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Nuclear Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Chung
authors.affiliation: Department of Nuclear Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: So
authors.affiliation: Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Nami
authors.initials: N
authors.lastname: Choi
authors.affiliation: Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Kim
keywords: Breast neoplasms; Breast specific gamma imaging; Mammography; Ultrasonography