title: Hypoglycemic Activity of Aqueous Root Bark Extract Zanthoxylum chalybeum in Alloxan-Induced Diabetic Rats.
abstract: BACKGROUND
  Medicinal plants offer cheaper and safer treatment options to current diabetic drugs. The present study evaluated the effect of aqueous root bark extract of Zanthoxylum chalybeum on oral glucose tolerance and pancreas histopathology in alloxanized rats.
  
  
  METHODS
  Diabetes was induced in rats by administration of alloxan monohydrate. Root extract of Z. chalybeum was administered to rats at 200 and 400 mg/kg BW daily for 28 days. Blood glucose was measured by glucometer and pancreatic histopathology evaluated microscopically.
  
  
  RESULTS
  Initial increase was observed in blood glucose of the rats after oral administration of glucose from time zero. Two hours after treatment with Z. chalybeum, a significant reduction in blood glucose was observed within treatment groups (p < 0.05) compared to 0.5 hr and 1 hr. There was no significant difference between treatment group receiving 400mg/Kg BW extract and the normal groups (p = 0.27), implying that the former group recovered and were able to regulate their blood sugar, possibly via uptake of glucose into cells. The reversal in pancreatic histopathology further supports the protective effect of Z. chalybeum extract towards diabetic damage.
  
  
  CONCLUSIONS
  Extract of Z. chalybeum is effective in controlling blood glucose in diabetes and protecting pancreatic tissues from diabetic damage.
authors.affiliation: Natural Chemotherapeutics Research Institute, Ministry of Health, Kampala, Uganda; Department of Biochemistry and Sports Science, College of Natural Sciences, Makerere University, Kampala, Uganda.
authors.forename: Moses Solomon
authors.initials: MS
authors.lastname: Agwaya
authors.affiliation: Department of Biochemistry and Sports Science, College of Natural Sciences, Makerere University, Kampala, Uganda.
authors.forename: Peter California
authors.initials: PC
authors.lastname: Vuzi
authors.affiliation: Department of Biochemistry and Sports Science, College of Natural Sciences, Makerere University, Kampala, Uganda.
authors.forename: Agnes Masawi
authors.initials: AM
authors.lastname: Nandutu
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D010946:Plants, Medicinal; D017208:Rats, Wistar; D013997:Time Factors; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan