title: [Molecular epidemiology of hand-foot-mouth disease associated pathogen Coxsackievirus A10 identified in Fujian province, 2011-2014].
abstract: OBJECTIVE
  To study the molecular epidemiology of hand-foot-mounth disease (HFMD) associated Coxsackievirus A10 (Cox A10) identified in Fujian province.
  
  
  METHODS
  A total of 1 525 specimens from non-EV71 non-Cox A16 HFMD patients were collected during 2011-2014. Isolated virus strains were identified and sub-typed. Full-length coding regions for the VP1 gene of the predominant serotype Cox A10 isolates were amplified and sequenced.
  
  
  RESULTS
  Among the 407 non-EV71 non-Cox A16 HFMD cases confirmed by virus isolation and molecular subtyping, 103 (25.3%) were caused by Cox A10, accounting for 11.0%, 6.0%, 18.4% and 9.2% among the HFMD-associated entero-viruses identified in 2011, 2012, 2013 and 2014, respectively, in Fujian province. Compared to the general features observed in the HFMD epidemics, no differences on the Cox A10-specificity rates were observed among factors as geographical origins, gender or age groups, but all with high rates of severity. Data from the nucleotide sequence analyses on VP1 genes showed low homology levels of 76.0%-77.1% among Cox A10 strains from Fujian province, in contrast to the prototype Cox A10 strain, but with high levels of homology in the amino acid sequences (91.9%-93.6%). RESULTS from the Phylogenetic analysis also indicated that Cox A10 isolates from Fujian province were distinct from the prototype strain or other isolates from other countries but was homologous to domestic strains, but the Fujian isolates clustered into multiple branches.
  
  
  CONCLUSIONS
  Cox A10 remained one of the predominant serotypes of HFMD in Fujian province. Cox A10 isolates identified in Fujian province were co-circulating and co-evolving with other domestic strains.
authors.affiliation: Department of Virus Disease Control, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Weng
authors.forename: Wenxiang
authors.initials: W
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Meng
authors.initials: M
authors.lastname: Huang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xie
authors.forename: Kuicheng
authors.initials: K
authors.lastname: Zheng
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Yan
mesh_terms: D044482:Benzeneacetamides; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D029821:Enterovirus A, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D058872:Epidemics; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000235:genetics / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D010881:Piperidones; D065288:Serogroup
chemical_list: D044482:Benzeneacetamides; D010881:Piperidones; C052091:antineoplaston A10