title: The longitudinal trends in the relationship between drug-induced extrapyramidal symptoms and personal and social performance in a population of the patients with schizophrenia: A latent growth model.
abstract: The aim of this study was to explore the longitudinal trends in the relationship between personal and social functioning and drug-induced extrapyramidal symptoms (DIEPS). The baseline sample included 484 patients with schizophrenia. Participants were assessed at baseline, weeks 4 (time 2), 8 (time 3), and 12 (time 4) regarding social functioning, and DIEPS. In latent growth analysis, the path coefficient between the intercept for the DIEPSS and the intercept for the PSP indicated a significant cross-sectional relationship between these two variables. And the path coefficient between the intercept of the DIEPSS and the slope of the PSP was also significant, indicating that patients who initially had more serious side effects tended to exhibit less improvement in their personal and social functioning over time. Similarly, a significant path coefficient between the slopes of the two variables indicated a dynamic and possibly reciprocal association over time. In addition, K-PSP scale showed good construct validity and reliability. Based on the standardized PSP scale, our results demonstrate DIEPSS induced by antipsychotic treatment dynamically affect personal and social functioning over time, a negative association between psychosocial aspects and the DIEPS.
authors.affiliation: Department of Psychology, Yonsei University, Seoul, Republic of Korea.
authors.forename: In-Jo
authors.initials: IJ
authors.lastname: Park
authors.affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: Dong Chung
authors.initials: DC
authors.lastname: Jung
authors.affiliation: Department of Psychology, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Samuel Suk-Hyun
authors.initials: SS
authors.lastname: Hwang
authors.affiliation: Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Psychiatry, SMG-SNUBoramae Medical Center, Seoul, Republic of Korea.
authors.forename: Hee Yeon
authors.initials: HY
authors.lastname: Jung
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
authors.affiliation: Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Chul-Eung
authors.initials: CE
authors.lastname: Kim
authors.affiliation: Department of Psychology, Yonsei University, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: aym@snu.ac.kr.
authors.forename: Yong Min
authors.initials: YM
authors.lastname: Ahn
authors.affiliation: Department of Psychiatry, Dongguk University, Ilsan Hospital, Goyang, Republic of Korea; Institute of Clinical Psychopharmacology, Dongguk University, Ilsan Hospital, Goyang, Republic of Korea. Electronic address: kys@snu.ac.kr.
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012917:Social Adjustment
chemical_list: D014150:Antipsychotic Agents
keywords: Drug-induced extrapyramidal symptoms; Personal and social functioning; Quality of life; Schizophrenia