title: Long Noncoding RNAs in Cancer Pathways.
abstract: Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: schmitta@mskcc.org.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Schmitt
authors.affiliation: Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: howchang@stanford.edu.
authors.forename: Howard Y
authors.initials: HY
authors.lastname: Chang
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D002451:Cell Compartmentation; D002455:Cell Division / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D016922:Cellular Senescence / Q000235:genetics; D002843:Chromatin / Q000648:ultrastructure; D018450:Disease Progression; D005544:Forecasting; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D009154:Mutation; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000032:analysis / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000378:metabolism; D014158:Transcription, Genetic; D059467:Transcriptome; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002843:Chromatin; D009363:Neoplasm Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016601:RNA-Binding Proteins