title: Seesaw of matrix metalloproteinases (MMPs).
abstract: The family of human matrix metalloproteinases (MMPs) comprises several tightly regulated classes of proteases. These enzymes and their specific inhibitors play important roles in tumor progression and the metastatic process by facilitating extracellular matrix (ECM) degradation. As scientific understanding of the MMPs has advanced, therapeutic strategies focusing on blocking these enzymes by MMP inhibitors (MMPIs) have rapidly developed. This paper reviews MMPs in detail. Their perspectives in therapeutic intervention in cancer are also mentioned.
authors.affiliation: Department of Oral Pathology and Microbiology, Bhojia Dental College, Baddi, Solan, India.
authors.forename: Charu
authors.initials: C
authors.lastname: Kapoor
authors.forename: Sharad
authors.initials: S
authors.lastname: Vaidya
authors.forename: Vijay
authors.initials: V
authors.lastname: Wadhwan
authors.forename: Geetpriya
authors.initials: G
authors.lastname: Kaur
authors.forename: Aparna
authors.initials: A
authors.lastname: Pathak
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D005109:Extracellular Matrix / Q000235:genetics; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000627:therapeutic use*; D020782:Matrix Metalloproteinases / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases