title: Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones.
abstract: A novel synthetic route to 1,3,5,7-tetrasubstituted pyrimido[4,5-d]pyrimidine-2,4-diones, of interest for potential antitumor activity, is reported. The route uses 1,3-disubstituted 6-amino uracils as starting materials. The key step is a hydrazine-induced cyclization reaction to form the fused pyrimidine ring. By choosing different uracils, acylation reagents and alkylation reagents, substituents at N-1, N-3, C-5, and C-7 may be selectively varied to provide a structurally diverse set of compounds for biological evaluation.
authors.affiliation: Department of Chemistry, The Scripps Research Institute-FL, 130 Scripps Way, Jupiter, FL 33458, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry, The Scripps Research Institute-FL, 130 Scripps Way, Jupiter, FL 33458, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Chemistry, The Scripps Research Institute-FL, 130 Scripps Way, Jupiter, FL 33458, USA.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Bannister
keywords: antitumor; heterocycles; inhibitor; pyrimidopyrimidines; synthesis