title: Effect of cytokine-induced killer cells on immune function in patients with lung cancer.
abstract: Cytokine-induced killer (CIK) cells have been used as adoptive immunotherapy in cancer. The present study evaluated the effect of CIK cells on immune function in patients with lung cancer. Patients were divided into three groups, according to the treatment received prior to CIK cell treatment: CIK group (no prior treatment), Che-Sur group (prior chemotherapy and surgery) and Che-Rad group (prior chemotherapy and radiotherapy). Following treatment, the average percentage of cluster of differentiation (CD)3+CD4+, CD3+, natural killer (NK) and NKT cells in peripheral blood was significantly higher than that prior to CIK treatment in the Che-Sur and CIK groups, and the levels of interferon-γ in serum were significantly higher than those prior to CIK treatment in the Che-Sur and CIK groups. On the contrary, the levels of interleukin-10 had decreased in these groups following CIK treatment. Subsequently, patients were divided into three groups according to the percentage of CD3+CD56+CIK cells that were administered to the patients. The number of NK and NKT cells increased with increasing number of CD3+CD56+cells. The patients in the CIK and Che-Sur groups were the most benefited ones following CIK treatment, contrarily to those in the Che-Rad group, since the increase in the number of CD3+CD56+CIK cells in the aforementioned patients enhanced the number of NK cells, which exhibit antitumor activity.
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ji
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Hongjiao
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Heshuang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Limin
authors.initials: L
authors.lastname: Sang
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cell Biological Treatment, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: Liangwei
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China.
authors.forename: L I
authors.initials: LI
authors.lastname: Zhang
keywords: cytokine-induced killer cells; immune function; lung cancer