title: Data from a comparative proteomic analysis of tumor-derived lung-cancer CD105(+) endothelial cells.
abstract: Increasing evidence indicates that tumor-derived endothelial cells (TECs) are more relevant for the study of tumor angiogenesis and for screening antiangiogenic drugs than normal ECs (NECs). In this data article, high-purity (>98%) primary CD105(+) NECs and TECs purified from a mouse Lewis lung carcinoma model bearing 0.5 cm tumors were identified using 2D-PAGE and Matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS). All the identified proteins were categorized functionally by Gene Ontology (GO) analysis, and gene-pathway annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, protein-protein interaction networks were also built. The proteomics and bioinformatics data presented here provide novel insights into the molecular characteristics and the early modulation of the TEC proteome in the tumor microenvironment.
authors.affiliation: Xiamen Center of Clinical Laboratory, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Jin
authors.affiliation: Respiratory Department, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Central Laboratory, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Pei
authors.affiliation: Hospital Infection Control Office, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Fu
authors.affiliation: Respiratory Department, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Lyu
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Science, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Peng
authors.affiliation: Central Laboratory, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Central Laboratory, Xiamen Women׳s and Children׳s Hospital, Xiamen, Fujian 361004, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Pharmacy, Xiamen Medical College, Xiamen, Fujian 361004, China.
authors.forename: Lianzhong
authors.initials: L
authors.lastname: Luo
authors.affiliation: Central Laboratory, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Huiqin
authors.initials: H
authors.lastname: Zhuo
keywords: 2D-PAGE; Lung cancer; MALDI-TOF; MS/MS; Tumor-derived endothelial cells