title: Imaging and histologic prognostic factors in triple-negative breast cancer and carcinoma in situ as a prognostic factor.
abstract: OBJECTIVE
  To analyze what factors in magnetic resonance imaging (MRI) and histological study of triple-negative breast cancers are related to tumor recurrence and to shorter disease-free survival. To analyze survival and recurrence in function of the presence of an in situ component.
  
  
  METHODS
  This was a retrospective study of MRI staging examinations in 122 women with triple-negative breast cancer done from 2007 through 2014. In the MRI, we evaluated morphological variables (size, margins, morphology, internal signal in T2-weighted sequences) and dynamic variables (perfusion and diffusion). In the histological study, we evaluated Ki67, p53, CK5/6, nuclear grade, and Scarff-Bloom grade, as well as the presence of an in situ component and tumor grade (high grade or not high grade). We compared the variables between patients with tumor recurrence and those without, and we conducted a survival analysis.
  
  
  RESULTS
  Non-nodular enhancement was more common in patients with tumor recurrence (p=0.038) and was associated with shorter disease-free survival (p=0.023). Neither diffusion restriction (p=0.079) nor ki67 (p=0.052) was associated with a worse prognosis. An in situ component was detected in 44% of triple-negative tumors, and a greater proportion of patients in the group with tumor recurrence had an in situ component; however, the presence of an in situ component was not associated with shorter survival (p = 0.185).
  
  
  CONCLUSIONS
  Non-nodular enhancement was associated with a worse prognosis. Diffusion restriction, ki67, and the presence of an in situ component were not associated with shorter disease-free survival.
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario Miguel Servet, Zaragoza, España. Electronic address: crissebseb@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Sebastián Sebastián
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: C
authors.initials: C
authors.lastname: García Mur
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: S
authors.initials: S
authors.lastname: Cruz Ciria
authors.affiliation: Servicio de Anatomía patológica, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: D S
authors.initials: DS
authors.lastname: Rosero Cuesta
authors.affiliation: Servicio de Urgencias, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: B
authors.initials: B
authors.lastname: Gros Bañeres
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D064726:Triple Negative Breast Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology*; D055815:Young Adult
keywords: Breast cancer; Carcinoma in situ; Cáncer de mama; Diffusion; Difusión; Magnetic resonance imaging; Marcadores pronósticos; Perfusion; Perfusión; Prognostic markers; Recidiva; Recurrence; Resonancia magnética; Triple-negative tumors; Tumores triple negativo; ki67; p53