title: Antibacterial Constituents of Hainan Morinda citrifolia (Noni) Leaves.
abstract: Noni (Morinda citrifolia L.) is an edible and medicinal plant distributed in Hainan, China. The antibacterial activities of the extracts of water (WE), petroleum ether (PEE), ethyl acetate (EAE), chloroform (CE), and n-butanol (BE) were assayed by the disk diffusion method. The results showed that the extracts from Noni leaves possessed antibacterial effects against Bacillus subtilis, Escherichia coli, Proteus vulgaris, and Staphylococcus aureus. Among 5 different extracts, the BE produced the best antibacterial activity. The samples were first extracted by ethanol, and the primary compounds in the BE fraction of ethanol extract was further isolated and identified. Six phenolic compounds, including 5, 15-dimethylmorindol, ferulic acid, p-hydroxycinamic acid, methyl 4-hydroxybenzoate, methyl ferulate, and methyl 4-hydroxycinnamate, were identifiedby NMR. The results indicated that the phenolic compounds might significantly contribute to antibacterial activities of Noni leaves.
authors.affiliation: College of Food Science and Technology, Huazhong Agricultural Univ, Hubei, 430070, PR China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Zhang
authors.affiliation: College of Food Science and Technology, Huazhong Agricultural Univ, Hubei, 430070, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: College of Food Science, Hainan Univ, Haikou, 570228, PR China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: College of Food Science, Hainan Univ, Haikou, 570228, PR China.
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Wang
authors.affiliation: College of Food Science, Hainan Univ, Haikou, 570228, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Food Science, Hainan Univ, Haikou, 570228, PR China.
authors.forename: Wang-Jun
authors.initials: WJ
authors.lastname: Hao
authors.affiliation: Inst. of Farm Product Processing, Jiangsu Academy of Agricultural Sciences, PR China.
authors.forename: Wu-Yang
authors.initials: WY
authors.lastname: Huang
mesh_terms: D000880:Anthraquinones / Q000032:analysis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002681:China; D002934:Cinnamates / Q000032:analysis / Q000494:pharmacology; D003373:Coumaric Acids / Q000032:analysis / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D032066:Morinda / Q000737:chemistry*; D010226:Parabens / Q000032:analysis / Q000494:pharmacology; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011514:Proteus vulgaris / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: C507957:5,15-O-dimethylmorindol; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D002934:Cinnamates; D003373:Coumaric Acids; D010226:Parabens; D010636:Phenols; D010936:Plant Extracts; C029010:cinnamic acid; C004999:ferulic acid; C038193:4-hydroxybenzoic acid
keywords: Morinda citrifolia (Noni) leaves; antibacterial activity; isolation and identification