title: Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke.
abstract: Therapeutic hypothermia is the most potent neuroprotectant for experimental cerebral ischemia, illustrated in a 2007 meta-analysis published in this journal. To address recent therapeutic nihilism, we systematically reviewed recent experimental literature. Quality scoring showed considerable improvement in study design. Using several outcome measures in a variety of models and species, therapeutic hypothermia was protective compared with normothermia, with powerful and statistically significant normalized treatment effect sizes, in 60 papers comprising 216 comparisons. In the past 5 years, preclinical studies of ischemic stroke re-emphasize that therapeutic hypothermia is potently effective, justifying further development in larger human clinical trials.
authors.affiliation: Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA Oana.dumitrascu@cshs.org.
authors.forename: Oana M
authors.initials: OM
authors.lastname: Dumitrascu
authors.affiliation: Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lamb
authors.affiliation: Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Lyden
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020521:Stroke / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Acute stroke; animal models; hypothermia; neuroprotection; reperfusion