title: CD34-positive infantile myofibromatosis: Case report and review of hemangiopericytoma-like pattern tumors.
abstract: We describe a case of CD34-positive infantile myofibromatosis with hemangiopericytoma-like pattern. A 2-day-old Japanese boy presented with multiple hemispherical nodules on the extremities and back. There was a biphasic histological growth in the dermis, accompanied by a hemangiopericytoma-like pattern with antler-like branching vessels. Tumor cells were oval to spindle-shaped myoid cells with bland appearance. Immunohistochemically, vimentin, calponin and CD34 were positive, while α-smooth muscle actin, h-caldesmon, HHF35 and desmin were negative. Although CD34 was positive, the present case could be diagnosed as infantile myofibromatosis. Myopericytoma, myofibroma/myofibromatosis, glomus tumor, glomangiopericytoma and angioleiomyoma share a continuous spectrum of benign hemangiopericytoma-like pattern tumors. Myofibroma/myofibromatosis is nearly included in myopericytoma among pericytic (perivascular) tumors, and could be positive for CD34. Several immunohistochemical panels of smooth muscle markers are needed for the diagnosis of pericytic (perivascular) tumors.
authors.affiliation: Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kiyohara
authors.affiliation: Department of Dermatology, University of Fukui, Fukui, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Maruta
authors.affiliation: Department of Dermatology, University of Fukui, Fukui, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Iino
authors.affiliation: Department of Dermatology, University of Fukui, Fukui, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ido
authors.affiliation: Department of Dermatology, University of Fukui, Fukui, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tokuriki
authors.affiliation: Department of Dermatology, University of Fukui, Fukui, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Hasegawa
mesh_terms: D000199:Actins / Q000276:immunology / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism*; D001034:Apgar Score; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002148:Calmodulin-Binding Proteins / Q000378:metabolism; D003893:Desmin / Q000378:metabolism; D006393:Hemangiopericytoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism; D018224:Myofibromatosis / Q000151:congenital* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D014746:Vimentin / Q000378:metabolism; D000096985:Calponins
chemical_list: D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D002148:Calmodulin-Binding Proteins; D003893:Desmin; D008840:Microfilament Proteins; D014746:Vimentin; D000096985:Calponins; C541116:ACTA2 protein, human
keywords: CD34; calponin; hemangiopericytoma; myofibroma; myopericytoma