title: Stress out the LINEs.
abstract: Occupying 17% of human genome, the mobile long interspersed element 1 (LINE-1 or L1) continues to modulate the landscape of our genome by inserting into new loci and, as a result, causing sporadic diseases. It is not surprising that human cells have evolved a battery of mechanisms to control and limit the activity of LINE-1. Our recent study unravels such a mechanism that is imposed by the stress granule pathway. This mechanism functions by sequestering the LINE-1 RNA-protein complex within the cytoplasmic stress granules and thus inhibiting the nuclear import of LINE-1 RNA and its subsequent reverse transcription and integration into cellular DNA. Conditions that promote stress granule formation, such as expression of the SAMHD1 protein, further reduce LINE-1 retrotransposition.
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, P. R. China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Hu
authors.affiliation: Lady Davis Institute, Jewish General Hospital , Montreal, Quebec, Canada.
authors.forename: Chen
authors.initials: C
authors.lastname: Liang
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, P. R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
keywords: LINE-1; SAMHD1; host restriction; retrotransposition; stress granule