title: Feasibility of vocal fold abduction and adduction assessment using cine-MRI.
abstract: OBJECTIVE
  Determine feasibility of vocal fold (VF) abduction and adduction assessment by cine magnetic resonance imaging (cine-MRI) METHODS: Cine-MRI of the VF was performed on five healthy and nine unilateral VF paralysis (UVFP) participants using an axial gradient echo acquisition with temporal resolution of 0.7 s. VFs were continuously imaged with cine-MRI during a 10-s period of quiet respiration and phonation. Scanning was repeated twice within an individual session and then once again at a 1-week interval. Asymmetry of VF position during phonation (VF phonation asymmetry, VFPa) and respiration (VF respiration asymmetry, VFRa) was determined. Percentage reduction in total glottal area between respiration and phonation (VF abduction potential, VFAP) was derived to measure overall mobility. An un-paired t-test was used to compare differences between groups. Intra-session, inter-session and inter-reader repeatability of the quantitative metrics was evaluated using intraclass correlation coefficient (ICC).
  
  
  RESULTS
  VF position asymmetry (VFPa and VFRa) was greater (p=0.012; p=0.001) and overall mobility (VFAP) was lower (p=0.008) in UVFP patients compared with healthy participants. ICC of repeatability of all metrics was good, ranged from 0.82 to 0.95 except for the inter-session VFPa (0.44).
  
  
  CONCLUSIONS
  Cine-MRI is feasible for assessing VF abduction and adduction. Derived quantitative metrics have good repeatability.
  
  
  CONCLUSIONS
  • Cine-MRI is used to assess vocal folds (VFs) mobility: abduction and adduction. • New quantitative metrics are derived from VF position and abduction potential. • Cine-MRI able to depict the difference between normal and abnormal VF mobility. • Cine-MRI derived quantitative metrics have good repeatability.
authors.affiliation: Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Marina Mat
authors.initials: MM
authors.lastname: Baki
authors.affiliation: Centre for Medical Imaging, University College London, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Menys
authors.affiliation: Centre for Medical Imaging, University College London, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK.|University College London Hospital NHS Trust, Royal National Throat Nose Ear Hospital, London, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Atkinson
authors.affiliation: University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Bassett
authors.affiliation: Centre for Medical Imaging, University College London, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Morley
authors.affiliation: Centre for Medical Imaging, University College London, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Beale
authors.affiliation: Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom.
authors.forename: Guri
authors.initials: G
authors.lastname: Sandhu
authors.affiliation: University College London Hospital NHS Trust, Royal National Throat Nose Ear Hospital, London, United Kingdom.
authors.forename: Georgekutty
authors.initials: G
authors.lastname: Naduvilethil
authors.affiliation: University College London Hospital NHS Trust, Royal National Throat Nose Ear Hospital, London, United Kingdom.
authors.forename: Nicola
authors.initials: N
authors.lastname: Stevenson
authors.affiliation: University College London Hospital NHS Trust, Royal National Throat Nose Ear Hospital, London, United Kingdom.|Department of Otolaryngology, University of California, Davis, Davis, CA, United States.|Ear Institute, University College London, London, United Kingdom.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Birchall
authors.affiliation: Centre for Medical Imaging, University College London, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK. shonit.punwani@gmail.com.|University College London Hospital NHS Trust, Royal National Throat Nose Ear Hospital, London, United Kingdom. shonit.punwani@gmail.com.
authors.forename: Shonit
authors.initials: S
authors.lastname: Punwani
mesh_terms: D000328:Adult; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D010699:Phonation; D015203:Reproducibility of Results; D014826:Vocal Cord Paralysis / Q000000981:diagnostic imaging*; D014827:Vocal Cords / Q000000981:diagnostic imaging*
keywords: Cine; Feasibility study; Magnetic resonance imaging; Vocal fold paralysis