title: Analysis of drug resistance in 1,861 strains ofAcinetobacter baumannii.
abstract: Acinetobacter baumanniiis an emerging human pathogen that causes hospital-acquired infections. The trend in increased antimicrobial resistance limits the choice of effective antimicrobial agents. The present study reports the resistance toAcinetobacter baumanniiand analyzes the associations between antibiotic use and resistance rates at a general hospital between 2010 and 2014. A total of 1,861 isolates were obtained from clinical cultures, accounting for 10.33% of all detected bacteria (1,861/18,016). The strains were mainly from respiratory samples (1,628 isolates, 87.5%) and the intensive care unit (696 isolates, 37.4%). The resistance rates ofAcinetobacter baumanniito the majority of antibiotics were >50%, particularly the resistance rate to cefoperazone/sulbactam increased from 47.37 in 2011 to 89.25% in 2014. However, the rates of imipenem and cilastatin sodium decreased from 81.03 to 69.44% due to the antibiotic policy. There were Pearson significant associations between the use of three antibiotics and resistance inAcinetobacter baumanniito this drug, piperacillin/tazobactam (r=0.976, P<0.01), gentamicin (r=0.870, P<0.01) and cefoxitin (r=0.741, P<0.05). Therefore, a combination of drugs should be adopted to treatAcinetobacter baumanniiinfections. Microbiology laboratory support and surveillance policies are essential to control the emergence of multidrug-resistanceAcinetobacter baumannii.
authors.affiliation: Department of Clinical Laboratory, Yancheng Third People's Hospital, Yancheng, Jiangsu 224005, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Pharmacy, Yancheng Vocational Institute of Health Science, Yancheng, Jiangsu 224005, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Qiu
authors.affiliation: Department of Clinical Laboratory, Yancheng Third People's Hospital, Yancheng, Jiangsu 224005, P.R. China.
authors.forename: Hong Jian
authors.initials: HJ
authors.lastname: Ji
authors.affiliation: Department of Clinical Laboratory, Yancheng Third People's Hospital, Yancheng, Jiangsu 224005, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
keywords: Acinetobacter baumannii; antibiotics usage; drug resistance