title: Human Serum Albumin Nanoparticles as a Novel Delivery System for Cabazitaxel.
abstract: BACKGROUND
  Due to use of Tween-80 as an enhancer of solubility, the current clinical formulation of cabazitaxel (CBT) (Jevtana®) causes hypersensitivity, neurotoxicity and other severe side-effects. To reduce these vehicle-related effects, a suitable nanocarrier is needed.
  
  
  METHODS
  Human serum albumin (HSA) was used to encapsulate CBT by a simple self-assembly method. Physicochemical properties of HSA-CBT nanoparticles were characterized. In vitro release property and cytotoxicity were also determined. In vivo imaging system was used to study nanocarrier distribution in vivo. The safety profile was assessed by hemolysis and acute-toxicity study. Finally, the antitumor efficacy in vivo was investigated in tumor-bearing mice.
  
  
  RESULTS
  The average size of HSA-CBT nanoparticles was about 240 nm and the encapsulation efficiency reached 97%. The hemolysis and acute-toxicity experiments confirmed biocompatibility of HSA-CBT nanoparticles.
  
  
  CONCLUSIONS
  HSA nanoparticles are a safe and effective drug delivery system for hydrophobic anticancer drugs such as CBT.
authors.affiliation: Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China.
authors.forename: Guoming
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Jin
authors.affiliation: Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Hangzhou Push-Kang Biotechnology Co., Ltd., Hangzhou, Zhejiang, P.R. China.
authors.forename: J U
authors.initials: JU
authors.lastname: Yao
authors.affiliation: Hangzhou Push-Kang Biotechnology Co., Ltd., Hangzhou, Zhejiang, P.R. China.
authors.forename: Yingxin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Lesheng
authors.initials: L
authors.lastname: Teng
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin, P.R. China Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lee
authors.affiliation: Hangzhou Push-Kang Biotechnology Co., Ltd., Hangzhou, Zhejiang, P.R. China czj100007@hotmail.com bjf0915@126.com.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China czj100007@hotmail.com bjf0915@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Hong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D045325:HCT116 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000008:administration & dosage* / Q000737:chemistry*; D012995:Solubility; D043823:Taxoids / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D012709:Serum Albumin; D043823:Taxoids; C552428:cabazitaxel
keywords: Cabazitaxel; human serum albumin; nanoparticle