title: Dietary intake and urinary level of cadmium and breast cancer risk: A meta-analysis.
abstract: Cadmium, a human carcinogenic heavy metal, has been reported to be associated with breast cancer risk; however, the results from the epidemiological studies are not always consistent. The objective of this study was to quantitatively summarize the current evidence for the relationship between cadmium exposure and breast cancer risk using meta-analysis methods. Six studies determining the dietary cadmium intake level and five studies evaluating the urinary cadmium level were identified in a systematic search of MEDLINE and PubMed databases, and the associations between these levels and breast cancer risk were analysed. The pooled estimates under the random-effects model suggested that higher urinary cadmium levels were associated with an increased risk for breast cancer (highest versus lowest quantile, pooled odds ratio [OR]=2.24, 95% confidence interval [95%CI]=1.49-3.35) and a 1μg/g creatinine increase in urinary cadmium led to a 1.02-fold increment of breast cancer (pooled OR=2.02, 95%CI=1.34-3.03); however, pooled estimates for dietary cadmium intake found no significant association between cadmium exposure and breast cancer risk (highest versus lowest quantile, pooled relative risk [RR]=1.01, 95%CI=0.89-1.15). These results suggest that cadmium exposure may lead to an increased risk of breast cancer, and urinary cadmium levels can serve as a reliable biomarker for long-term cadmium exposure and may predict the breast cancer risk.
authors.affiliation: School of Public Health, Guangzhou Medical University, Guangzhou 510182, People's Republic of China; Longgang Central Hospital of Shenzhen, Shenzhen 518116, People's Republic of China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Lin
authors.affiliation: School of Public Health, Guangzhou Medical University, Guangzhou 510182, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Public Health, Guangzhou Medical University, Guangzhou 510182, People's Republic of China. Electronic address: yixionglei_gz@163.com.
authors.forename: Yixiong
authors.initials: Y
authors.lastname: Lei
mesh_terms: D001943:Breast Neoplasms / Q000139:chemically induced*; D002104:Cadmium / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D012306:Risk
chemical_list: D002104:Cadmium
keywords: Breast cancer risk; Cadmium; Dietary intake; Meta-analysis; Urine