title: Improved Diagnosis of the Polysensitized Allergic Rhinitis Patients Using Component Resolved Diagnosis Method.
abstract: Allergy diagnosis needs to be improved in polysensitized patients due to the existence of possible confounding factors in this type of patients. Component resolved diagnosis (CRD) is a new concept in the investigation of polysensitized patients. The aim of this study was to evaluate if the utilization of ImmunoCAP ISAC improve the diagnosis of the polysensitized allergic rhinitis patients. Skin prick test (SPT) to 58 crude allergen extracts and CRD (ImmunoCAP ISAC) were carried out for 5 polysensitized allergic rhinitis patients. Two patients had a shellfish allergy and avoidance of shellfish was the only way to prevent an allergic reaction. In contrast, although the remaining three patients had low risk for shellfish allergy, but they were the best candidates for immunotherapy using mite extracts. CRD and particularly ImmunoCAP ISAC have proven to be a valuable diagnostic tool in polysensitized patients. ImmunoCAP ISAC helps refine the individual patient's sensitization profile and predict the potential risk of allergic reactions and improve the selection of patients for immunotherapy.
authors.affiliation: Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Zailatul Hani
authors.initials: ZH
authors.lastname: Mohamad Yadzir
authors.affiliation: Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Faizal
authors.initials: F
authors.lastname: Bakhtiar
authors.affiliation: Department of Biology, Faculty of Science and Mathematics, University Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.
authors.forename: Rosmilah
authors.initials: R
authors.lastname: Misnan
authors.affiliation: Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Noormalin
authors.initials: N
authors.lastname: Abdullah
authors.affiliation: Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Brenda
authors.initials: B
authors.lastname: Leecyous
authors.affiliation: Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Murad
mesh_terms: D000328:Adult; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D045424:Complex Mixtures / Q000008:administration & dosage / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D065631:Rhinitis, Allergic / Q000175:diagnosis* / Q000276:immunology; D012758:Shellfish; D000067208:Shellfish Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D012882:Skin Tests / Q000379:methods
chemical_list: D000485:Allergens; D045424:Complex Mixtures
keywords: Allergic rhinitis; Component resolved diagnosis; Skin prick testing