title: The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders.
abstract: Previous studies demonstrated levels of serum CK (sCK) in the majority of patients undergoing acute psychosis. Records of 1054 patients hospitalized in Geha Mental Health Center during the study period were analyzed. Of them, 743 have been diagnosed with schizophrenia (Sz), 170 with schizoaffective disorder (SzA), and 158 with bipolar disorder (BP-I). Baseline sCK and PANSS values were obtained from each patient upon admission. Our results show that LnsCK is higher in patients with BP-I in comparison with patients with SZ, but not significantly different compared to patients with SzA. A multivariate analysis using linear regression model in which LnsCK was predicted by factors such as PANSS-total and sub-scores, IM injection, BMI, gender, and age among patients at each admission, revealed that PANSS-depression was inversely associated with LnsCK level in SzA and BP-I and not in SZ. A positive association was found between PANSS-total and sCK in SzA and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. After controlling for confounders, it seems that sCK level is associated with the both affective and psychotic components. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address: shollander@ucdavis.edu.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hollander
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel; Geha Mental Health Center, Israel.
authors.forename: Eldar
authors.initials: E
authors.lastname: Hochman
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel; Geha Mental Health Center, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Shoval
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Taler
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: Sharon
authors.initials: S
authors.lastname: Trommer
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel; Geha Mental Health Center, Israel.
authors.forename: Haggai
authors.initials: H
authors.lastname: Hermesh
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel; Geha Mental Health Center, Israel; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Israel; Geha Mental Health Center, Israel; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Krivoy
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D001714:Bipolar Disorder / Q000523:psychology*; D003402:Creatine Kinase / Q000097:blood*; D003863:Depression; D003866:Depressive Disorder / Q000175:diagnosis; D005260:Female; D006760:Hospitalization; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology; D011618:Psychotic Disorders / Q000523:psychology*; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis*
chemical_list: D003402:Creatine Kinase
keywords: Affect; Bipolar disorder; Creatine kinase; Depression; Mood disorders; Psychopathology; Psychotic disorders