title: Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study.
abstract: Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p<0.001) and MS (54.3%, p<0.05) reduced significantly in the SLIT group. There was a significant improvement of MS and CS in the SLIT compared to control group (p<0.001 and p<0.05 respectively). There was no significant improvement of SS as well as specific slgE. Patients in the SLIT group were more satisfied with treatment (p<0.001). The incidence of mild adverse reaction was 38.4%. Specific lgG was not done. One year SLIT with D.pt extract was clinically efficient treatment in AR patients.
authors.affiliation: Clinic for Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia AND Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Tomic-Spiric
authors.initials: TS
authors.lastname: Vesna
authors.affiliation: Clinic for Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia AND Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Dizdarevic
authors.initials: D
authors.lastname: Denisa
authors.affiliation: Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Jankovic
authors.initials: J
authors.lastname: Slavenka
authors.affiliation: Department of Allergy, Institute of Virology, Vaccines and Sera "Torlak", Belgrade, Serbia.
authors.forename: Burazer
authors.initials: B
authors.lastname: Lidija
authors.affiliation: Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Barac
authors.initials: B
authors.lastname: Aleksandra
authors.affiliation: Clinic for Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia AND Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Bolpacic
authors.initials: B
authors.lastname: Jasna
authors.affiliation: Clinic for Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia AND Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Djuric
authors.initials: D
authors.lastname: Vojislav
authors.affiliation: Clinic for Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia AND Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Peric-Popadic
authors.initials: PP
authors.lastname: Aleksandra
authors.affiliation: Department of Ear, Nose and Throat, University Hospital, Clinical Center of Banja Luka, Banja Luka, Bosnia and Herzegovina.
authors.forename: Aleksic
authors.initials: A
authors.lastname: Aleksandra
authors.affiliation: Clinic for Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia AND Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Bogic
authors.initials: B
authors.lastname: Mirjana
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001249:Asthma / Q000276:immunology / Q000628:therapy; D045424:Complex Mixtures / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D040002:Dermatophagoides pteronyssinus / Q000737:chemistry / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D065631:Rhinitis, Allergic / Q000276:immunology / Q000628:therapy; D063729:Sublingual Immunotherapy / Q000379:methods*
chemical_list: D045424:Complex Mixtures; D007074:Immunoglobulin G
keywords: Allergic rhinitis; Asthma; Dermatophagoides pteronyssinus; Efficacy; Sublingual Immunotherapy