title: Percutaneous Cryoablation of Extraabdominal Desmoid Tumors: A 10-Year Experience.
abstract: OBJECTIVE
  Extraabdominal desmoid (EAD) tumors pose a therapeutic challenge because they often recur locally and behave aggressively. Accepted management options include surgery, radiation, chemotherapy, and observation. The objective of this study was to assess the safety and efficacy of percutaneous cryoablation for the treatment of EAD tumors.
  
  
  METHODS
  A retrospective search of our cryoablation database was performed to identify patients with EAD tumors treated with percutaneous cryoablation between June 15, 2004, and June 15, 2014. During this 10-year time period, we treated 18 patients with 26 discrete tumors during 31 treatment sessions. After cryoablation, contrast-enhanced MRI or CT was performed. Any enhancing soft tissue was considered viable EAD tumor and was measured in three planes.
  
  
  RESULTS
  Of the 26 EAD tumors treated, follow-up imaging with IV contrast material was available for 23 tumors. The mean imaging follow-up was 16.2 ± 20.0 (SD) months. All 31 sessions were technically successful procedures. No residual viable EAD tumor was observed in nine of 23 tumors (39.1%). Some degree of volume reduction was evident in 22 of 23 tumors (95.7%). Progressive disease was observed in one of the 23 tumors (4.3%). Of the cases with residual or progressive disease, the recurrence occurred at the margin of the treated tumor in all cases. No major complications were observed, and none of the complications was more severe than Clavien-Dindo grade I.
  
  
  CONCLUSIONS
  Percutaneous cryoablation is a safe, effective, and repeatable treatment for achieving local control of EAD tumors.
authors.affiliation: 1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55902.
authors.forename: John J
authors.initials: JJ
authors.lastname: Schmitz
authors.affiliation: 1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55902.
authors.forename: Grant D
authors.initials: GD
authors.lastname: Schmit
authors.affiliation: 1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55902.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Atwell
authors.affiliation: 1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55902.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Callstrom
authors.affiliation: 1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55902.
authors.forename: Anil N
authors.initials: AN
authors.lastname: Kurup
authors.affiliation: 1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55902.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Weisbrod
authors.affiliation: 1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55902.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Morris
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D003287:Contrast Media; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D018222:Desmoid Tumors / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media
keywords: aggressive fibromatosis; cryoablation; cryotherapy; extraabdominal desmoid tumor