title: Four new diterpenoids isolated from the Euphorbia rapulum.
abstract: Four new diterpenoids named 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3) and tagalsin I (4) were isolated from Euphorbia rapulum. The structures of these compounds were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for cytotoxic activities against HepG2, MCF-7, and C6 cell lines, and compound 4 showed moderate selective activity against MCF-7 cell line with an IC50 value of 31.8 μM.
authors.affiliation: a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Xiao-Xue
authors.initials: XX
authors.lastname: Liu
authors.affiliation: b School of Pharmacy , China Medical University , Shenyang 110122 , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shang
authors.affiliation: c School of Pharmacy , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.affiliation: b School of Pharmacy , China Medical University , Shenyang 110122 , China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Feng
authors.affiliation: c School of Pharmacy , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: c School of Pharmacy , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sha
authors.affiliation: a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D051381:Rats
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C509787:tagalsin I
keywords: Euphorbia rapulum; Euphorbiaceae; cytotoxic activities; diterpenoids