title: Successful Use of High-dose Daptomycin in a Child With Staphylococcus aureus Endocarditis.
abstract: We report the successful use of daptomycin in a child with methicillin-resistant Staphylococcus aureus endocarditis with persistent bacteremia and clinical deterioration, despite treatment with vancomycin and rifampicin. She had acute kidney injury, requiring daptomycin dosage adjustment.
authors.affiliation: From the *Department of Pediatric Critical Care, †Department of Infectious Disease, and †Department of Pediatric Cardiology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.
authors.forename: Sumant
authors.initials: S
authors.lastname: Prabhudesai
authors.forename: Amruta
authors.initials: A
authors.lastname: Kanjani
authors.forename: P Senthur
authors.initials: PS
authors.lastname: Nambi
authors.forename: S
authors.initials: S
authors.lastname: Gnanasambandam
authors.forename: Bala
authors.initials: B
authors.lastname: Ramachandran
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D002675:Child, Preschool; D017576:Daptomycin / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D012293:Rifampin / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D017576:Daptomycin; D012293:Rifampin