title: [Classical osteosarcoma in children and adolescent].
abstract: Classical osteosarcoma is one of the most common primary malignant bone tumors in children and adolescents. It more frequently occurs in the areas of the highest growth plate proliferation: limb long bones particularly in the distal femur (30%), proximal tibia (15%), and proximal humerus (15%). In the long bones, the tumor is located usually in the metaphysis (90%), less frequently in the diaphysis (9%), and very rarely in the epiphysis. This paper considers the clinical, radiological, and histological diagnosis, and prognosis in this pathology.
authors.affiliation: Russian Children's Clinical Hospital; D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Rogozhin
authors.affiliation: Russian Children's Clinical Hospital.
authors.forename: I V
authors.initials: IV
authors.lastname: Bulycheva
authors.affiliation: Russian Children's Clinical Hospital; D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: D M
authors.initials: DM
authors.lastname: Konovalov
authors.affiliation: Russian Children's Clinical Hospital; D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Talalaev
authors.affiliation: Russian Children's Clinical Hospital; D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Roshchin
authors.affiliation: Russian Children's Clinical Hospital; D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: A P
authors.initials: AP
authors.lastname: Ektova
authors.affiliation: Russian Children's Clinical Hospital.
authors.forename: Yu S
authors.initials: YS
authors.lastname: Bogoroditsky
authors.affiliation: Russian Children's Clinical Hospital.
authors.forename: V A
authors.initials: VA
authors.lastname: Strykov
authors.affiliation: D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Kazakova
authors.affiliation: D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Olshanskaya
authors.affiliation: D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: D Yu
authors.initials: DY
authors.lastname: Kachanov
authors.affiliation: D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Tereshchenko
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology*; D001842:Bone and Bones / Q000503:physiopathology*; D002648:Child; D003937:Diagnosis, Differential; D005269:Femur / Q000503:physiopathology*; D006801:Humans; D012516:Osteosarcoma / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology*