title: Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: A critical review.
abstract: Chemokines are small chemotactic proteins that coordinate circulation of immune/inflammatory cells throughout body compartments. Because of this property chemokines and their cell surface receptors are implicated in several physiological and pathological conditions, including cancer. These molecules are expressed by neoplastic or stromal cells and have effects at tumor primary site (e.g. stimulating angiogenesis and tumor cells motility) and lymph nodes (creating a gradient to direct migration of neoplastic cells). In this article we review the current knowledge about the function(s) of chemokines and receptors in squamous cell carcinoma from the oral cavity and head and neck region. Accumulating evidence suggests some chemokine(s) and receptor(s) as potential targets in adjuvant therapies for these malignancies.
authors.affiliation: Department of Oral Surgery and Pathology, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Janine Mayra
authors.initials: JM
authors.lastname: da Silva
authors.affiliation: Department of Stomatology (Oral Pathology), Faculdade de Odontologia, Universidade Federal de Goiás, Goiânia, Brazil.
authors.forename: Danilo Figueiredo
authors.initials: DF
authors.lastname: Soave
authors.affiliation: Department of Oral Surgery and Pathology, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Tálita Pollyanna
authors.initials: TP
authors.lastname: Moreira Dos Santos
authors.affiliation: Department of Stomatology (Oral Pathology), Faculdade de Odontologia, Universidade Federal de Goiás, Goiânia, Brazil.
authors.forename: Aline Carvalho
authors.initials: AC
authors.lastname: Batista
authors.affiliation: Department of Physiology and Biophysics, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Remo Castro
authors.initials: RC
authors.lastname: Russo
authors.affiliation: Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.affiliation: Department of Oral Surgery and Pathology, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: tarcilia@ufmg.br.
authors.forename: Tarcília Aparecida
authors.initials: TA
authors.lastname: da Silva
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000378:metabolism*; D006801:Humans; D019707:Receptors, Chemokine / Q000378:metabolism*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine
keywords: Chemokines; Head and neck squamous cell carcinoma; Inflammation