title: The loss of neural synchrony in the post septic brain.
abstract: OBJECTIVE
  Survivors of sepsis often develop long-term neuropsychological malfunctions, which can be reversible to a certain extent. The following study aimed to investigate whether this recovery is due to a loss in neural synchrony by regarding the response to a given frequency.
  
  
  METHODS
  Magnetoencephalography measurements were conducted in 36 survivors of severe sepsis and septic shock three times within a time range of 12months after discharge from intensive care unit. We analyzed steady state visual evoked responses using a set of familiar vs. unfamiliar pictures.
  
  
  RESULTS
  Sepsis survivors exhibit oscillatory deficits in terms of an impaired response to periodic visual stimulation. Oscillatory deficits and neuropsychological impairments obtained by the DemTect questionnaire were strongly linked. Impaired responses were equally found during the presentation of familiar and unfamiliar stimuli. Compared to familiar stimuli however, the response to unfamiliar stimuli was significantly lower in the follow up but not in the post-acute stage.
  
  
  CONCLUSIONS
  We assume that the processing of unfamiliar pictures requires a higher amount of networking. In case of a disrupted network, complex networking might not be maintained.
  
  
  CONCLUSIONS
  Results indicate that neural synchrony might be restored to a certain level while more complex networking remains impaired.
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; CSCC, Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: theresa@biomag.uni-jena.de.
authors.forename: Theresa
authors.initials: T
authors.lastname: Götz
authors.affiliation: CSCC, Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: Philipp.Baumbach@med.uni-jena.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Baumbach
authors.affiliation: CSCC, Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; Division of Gastroenterology, Hepatology and Infectious Diseases, Department of Internal Medicine II, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: Philipp.Reuken@med.uni-jena.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Reuken
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: rhuonker@biomag.uni-jena.de.
authors.forename: Ralph
authors.initials: R
authors.lastname: Huonker
authors.affiliation: Neuropsychology Lab, Department of Psychology, Cluster of excellence "Hearing4all", European Medical School, University of Oldenburg, 26111 Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Germany. Electronic address: cornelia.kranczioch@uni-oldenburg.de.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Kranczioch
authors.affiliation: Neuropsychology Lab, Department of Psychology, Cluster of excellence "Hearing4all", European Medical School, University of Oldenburg, 26111 Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Germany. Electronic address: stefan.debener@uni-oldenburg.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Debener
authors.affiliation: Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 27, 07747 Jena, Germany. Electronic address: Frank.Brunkhorst@med.uni-jena.de.
authors.forename: Frank M
authors.initials: FM
authors.lastname: Brunkhorst
authors.affiliation: Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: otto.witte@med.uni-jena.de.
authors.forename: Otto W
authors.initials: OW
authors.lastname: Witte
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: carsten.klingner@med.uni-jena.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Klingner
authors.affiliation: Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: albrecht.guenther@med.uni-jena.de.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Günther
mesh_terms: D001921:Brain / Q000503:physiopathology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D018805:Sepsis / Q000503:physiopathology*; D017741:Survivors
keywords: Long-term cognitive impairments; Magnetoencephalography; Neuronal oscillations; Sepsis