title: Growth hormone secreting pituitary adenoma with admixed gangliocytoma and ganglioglioma.
abstract: Pituitary adenomas are the most common tumours found in the sellar region and, when both functioning and non-functioning adenomas are combined, account for 7-15% of primary brain tumours in adults. Rarely, admixed or discrete groups of cells comprising two or more tumour subtypes are seen; the so-called 'collision tumour'. We present a case of a 54-year-old-woman with a growth hormone-secreting pituitary adenoma admixed with both ganglioglioma and gangliocytoma. The possible mechanisms by which this may occur include a pre-existing gangliocytoma promoting the development of pituitary adenoma by hypersecretion of releasing hormones or aberrant migration of hypothalamic neurons in early embryogenesis.
authors.affiliation: Department of Neurosurgery, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, Sydney, NSW 2050, Australia. Electronic address: alistairjukes@me.com.
authors.forename: Alistair
authors.initials: A
authors.lastname: Jukes
authors.affiliation: Department of Neurosurgery, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, Sydney, NSW 2050, Australia.
authors.forename: Rodney
authors.initials: R
authors.lastname: Allan
authors.affiliation: Department of Neuropathology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Rawson
authors.affiliation: Department of Neuropathology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Buckland
mesh_terms: D000236:Adenoma / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D018303:Ganglioglioma / Q000473:pathology*; D005729:Ganglioneuroma / Q000473:pathology*; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000473:pathology*; D006801:Humans; D008875:Middle Aged
keywords: Gangliocytoma; Ganglioglioma; Growth hormone; Pituitary tumour