title: Effects of Kudoa septempunctata genotype ST3 isolate from Korea on ddY suckling mice.
abstract: This study investigated the effects of Kudoa septempunctata genotype ST3 spores on ddY suckling mice. Purified Kudoa septempunctata spores were administered into the stomachs of the mice at 5 × 10(6) or 5 × 10(7) spores/mouse, with inactivated Kudoa (5 × 10(6) spores/mouse) or vehicle as controls. No abnormal clinical symptoms were observed and there were no variations in fluid accumulation ratio and cytokine gene expression in all groups. In addition, intact Kudoa spores and the 18S rDNA gene were only detected (by microscopy and quantitative PCR, respectively) in the groups administered such spores. This study thus confirms that spores from the ST3 strain of Kudoa septempunctata were excreted in the faeces without infecting the gastrointestinal tract in ddY suckling mice.
authors.affiliation: Ocean and Fisheries Research Institute, Jeju Special Self-Governing Province, Pyoseon-myeon, Segwipo-si, Jeju 63629, Republic of Korea.
authors.forename: Yeounghwan
authors.initials: Y
authors.lastname: Jang
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Meejung
authors.initials: M
authors.lastname: Ahn
authors.affiliation: College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Hyojin
authors.initials: H
authors.lastname: Bang
authors.affiliation: Ocean and Fisheries Research Institute, Jeju Special Self-Governing Province, Pyoseon-myeon, Segwipo-si, Jeju 63629, Republic of Korea.
authors.forename: Bongjo
authors.initials: B
authors.lastname: Kang
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001681:Biological Assay; D016207:Cytokines / Q000097:blood; D005243:Feces / Q000469:parasitology; D005393:Fish Diseases / Q000469:parasitology; D005432:Flounder / Q000469:parasitology; D016266:Food Parasitology; D005838:Genotype; D058507:Host Specificity; D007411:Intestinal Diseases, Parasitic / Q000469:parasitology / Q000635:transmission / Q000662:veterinary; D051379:Mice; D055764:Myxozoa / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D010273:Parasitic Diseases, Animal / Q000469:parasitology / Q000635:transmission*; D056910:Republic of Korea; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms; D014774:Virulence / Q000235:genetics
chemical_list: D016207:Cytokines