title: Focus Issue: New insights in GPCR to G protein signaling.
abstract: This Focus Issue highlights new discoveries at the level of the receptor, the α subunit, and the βγ subunit and spans research in yeast on polarized growth and G protein-coupled receptor (GPCR) trafficking, in mice on an orphan GPCR with constitutive activity, and a disease-causing mutation in an α subunit that results in inappropriate GPCR-G protein coupling.
authors.affiliation: Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA. ngough@aaas.org.
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
mesh_terms: D000818:Animals; D004423:Ear / Q000002:abnormalities*; D004427:Ear Diseases / Q000235:genetics* / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009154:Mutation; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled; D029701:Saccharomyces cerevisiae Proteins; D019204:GTP-Binding Proteins