title: The Metabolic Syndrome and Its Influence on Nonalcoholic Steatohepatitis.
abstract: Nonalcoholic steatohepatitis (NASH) and the metabolic syndrome (MetS) are highly prevalent in the Western population. Their pathogenesis is closely linked to insulin resistance, which serves as a therapeutic target for the management of these conditions. This review article reviews the research supporting the influence of MetS on NASH and includes studies supporting their similar epidemiology, pathogenesis, and treatment.
authors.affiliation: Department of Gastroenterology and Hepatology, New York Methodist Hospital, 506, 6th Street, Brooklyn, NY 11215, USA.
authors.forename: Pushpjeet
authors.initials: P
authors.lastname: Kanwar
authors.affiliation: Department of Transplant Hepatology, Swedish Medical Center, 1101, Madison Street, Suite 200, Seattle, WA 98104, USA. Electronic address: kris.kowdley@swedish.org.
authors.forename: Kris V
authors.initials: KV
authors.lastname: Kowdley
mesh_terms: D054392:Adipokines / Q000378:metabolism; D015897:Comorbidity; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D012307:Risk Factors
chemical_list: D054392:Adipokines
keywords: Hepatocellular carcinoma; Metabolic syndrome; NAFLD; Nonalcoholic steatohepatitis; Risk factors