title: Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin.
abstract: The aim of this study is to examine and compare the similarities and differences between active components of S. miltiorrhiza depside salt and aspirin using perspective of pharmacological molecular networks. Active components of S. miltiorrhiza depside salt and aspirin's related genes were identified via the STITCH4.0 and GeneCards Database. A text search engine (Agilent Literature Search 2.71) and MCODE software were applied to construct network and divide modules, respectively. Finally, 32, 2, and 28 overlapping genes, modules, and pathways were identified between active components of S. miltiorrhiza depside salt and aspirin. A multidimensional framework of drug network showed that two networks reflected commonly in human aortic endothelial cells and atherosclerosis process. Aspirin plays a more important role in metabolism, such as the well-known AA metabolism pathway and other lipid or carbohydrate metabolism pathways. S. miltiorrhiza depside salt still plays a regulatory role in type II diabetes mellitus, insulin resistance, and adipocytokine signaling pathway. Therefore, this study suggests that aspirin combined with S. miltiorrhiza depside salt may be more efficient in treatment of CHD patients, especially those with diabetes mellitus or hyperlipidemia. Further clinical trials to confirm this hypothesis are still needed.
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street, Dongzhimennei, Dongcheng District, Beijing 100700, China.
authors.forename: Yuan
authors.identifier: 0000-0002-5311-9561
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street, Dongzhimennei, Dongcheng District, Beijing 100700, China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street, Dongzhimennei, Dongcheng District, Beijing 100700, China.
authors.forename: Lianxin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street, Dongzhimennei, Dongcheng District, Beijing 100700, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street, Dongzhimennei, Dongcheng District, Beijing 100700, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Epidemiology, University of California, Los Angeles, 405 Hilgard Avenue, CA 90095, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chai