title: Testosterone Replacement Therapy and BPH/LUTS. What is the Evidence?
abstract: Contrary to the previous dogma that prostatic growth is directly proportional to testosterone levels, emerging research has suggested a lack of testosterone may be a risk factor for lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Within this review article, we have demonstrated the current understanding of the physiology of hypogonadism and its interplay with prostatic and lower urinary tract physiology. The current evidence suggests that not only does testosterone replacement therapy (TRT) not worsen LUTS, but that hypogonadism itself is an important risk factor for LUTS/BPH.
authors.affiliation: Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Wesley
authors.initials: W
authors.lastname: Baas
authors.affiliation: Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA. tkohler@siumed.edu.
authors.forename: Tobias S
authors.initials: TS
authors.lastname: Köhler
mesh_terms: D000818:Animals; D020249:Hormone Replacement Therapy; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy*; D008297:Male; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D012307:Risk Factors; D013739:Testosterone / Q000627:therapeutic use*
chemical_list: D013739:Testosterone
keywords: Benign prostatic hyperplasia; Lower urinary tract symptoms; Testosterone replacement therapy