title: Characterization of sorbitan surfactant-based vesicles at the molecular scale using NMR: Effect of acyl chain length vs. phospholipid composition.
abstract: We focused on the characterization of the hydrophobic-hydrophilic interface of the membrane of vesicles prepared with various sorbitan surfactants using two evaluation methods: Laurdan fluorescence intensity (GP(340) value) and NMR analysis (half linewidth). Laurdan fluorescence intensity analysis, used to evaluate the hydrophobicity of the interior of the vesicular membrane, indicated a similarity between Span vesicles and liposomes in terms of hydrophobicity, while NMR analysis, used to assess the mobility of lipid molecules, indicated a large difference between Span vesicles and liposomes in terms of molecular mobility at the interface. These results suggest that the physicochemical properties of Span vesicles and liposomes are roughly similar at the "meso-scale" but not completely similar at the "molecular scale."
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata-cho, Yamatokoriyama, Nara 639-1080, Japan. Electronic address: hayashi@chem.nara-k.ac.jp.
authors.forename: Keita
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata-cho, Yamatokoriyama, Nara 639-1080, Japan.
authors.forename: Hideka
authors.initials: H
authors.lastname: Iwai
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata-cho, Yamatokoriyama, Nara 639-1080, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamei
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata-cho, Yamatokoriyama, Nara 639-1080, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Kato
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata-cho, Yamatokoriyama, Nara 639-1080, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murata
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata-cho, Yamatokoriyama, Nara 639-1080, Japan.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan. Electronic address: umakoshi@chem.es.osaka-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Umakoshi
mesh_terms: D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000737:chemistry; D000215:Acylation; D057927:Hydrophobic and Hydrophilic Interactions; D007848:Laurates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D010743:Phospholipids / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D007848:Laurates; D008567:Membranes, Artificial; D010743:Phospholipids; D011136:Polysorbates; D013501:Surface-Active Agents; D015081:2-Naphthylamine; C065580:laurdan
keywords: Membrane property; Molecular mobility; Tailor-made drug carrier; Vesicle