title: Is there an association between oral submucous fibrosis and ABO blood grouping?
abstract: BACKGROUND
  Oral submucous fibrosis (OSMF) is one of the most common premalignant conditions in Indian subcontinent due to the traditional use of Areca nut and its various preparations. The genetic predisposition has also been reported in its etiopathogenesis. The rate of malignant transformation is between 7% to 14%.
  
  
  OBJECTIVE
  To evaluate whether ABO blood group is related to OSMF risk.
  
  
  METHODS
  It was a cross-sectional hospital-based study. A convenient sample of 164 study subjects constituted the cases and 180 subjects constituted the comparison group.
  
  
  METHODS
  The results were analyzed using chi-square test and odds ratio.
  
  
  RESULTS
  The chi-square analysis could not establish any significant relationship between OSMF and ABO blood group. But, when the strength of the association was measured using odds ratio, subjects with blood group A had 1.181 times higher risk of developing OSMF in comparison to other groups.
  
  
  CONCLUSIONS
  The subjects with blood group A were at higher risk of developing OSMF in comparison to others. By performing blood group determination using a routine method at outreach programs, the susceptible individuals can be identified and counselled to quit the habit, thereby avoiding potential complications.
authors.affiliation: Department of Public Health Dentistry, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Venu K
authors.initials: VK
authors.lastname: Gopal Reddy
authors.forename: Ninad J
authors.initials: NJ
authors.lastname: Moon
authors.forename: Vijayta
authors.initials: V
authors.lastname: Sharva
authors.forename: Eshwar K
authors.initials: EK
authors.lastname: Reddy
authors.forename: Sujitha
authors.initials: S
authors.lastname: Chandralkala
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009914:Oral Submucous Fibrosis / Q000097:blood / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
chemical_list: D000017:ABO Blood-Group System