title: Circadian System and Glucose Metabolism: Implications for Physiology and Disease.
abstract: The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-h rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Recent studies indicate that the circadian system is important in regulating the daily rhythm in glucose metabolism. Disturbance of this circadian control or of its coordination relative to the environmental/behavioral cycle, such as in shift work, eating late, or due to genetic changes, results in disturbed glucose control and increased type 2 diabetes risk. Therefore, an in-depth understanding of the mechanisms underlying glucose regulation by the circadian system and its disturbance may help in the development of therapeutic interventions against the deleterious health consequences of circadian disruption.
authors.affiliation: Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jqian@bwh.harvard.edu.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Qian
authors.affiliation: Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: fscheer@bwh.harvard.edu.
authors.forename: Frank A J L
authors.initials: FAJL
authors.lastname: Scheer
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008550:Melatonin / Q000378:metabolism; D012890:Sleep / Q000235:genetics / Q000502:physiology
chemical_list: D005947:Glucose; D008550:Melatonin
keywords: circadian rhythms; food timing; glucose metabolism; melatonin; sleep; type 2 diabetes