title: Serum Osteoprotegerin Is Associated With Calcified Carotid Plaque: A Strobe-Compliant Observational Study.
abstract: Osteoprotegerin (OPG) is a kind of tumor necrosis factor, which is related to bone metabolism and vascular calcification. The increase of Osteoprotegerin concentration in serum is related to cardiovascular diseases in humans. The purpose of this study was to figure out the relevance between osteoprotegerin in serum and carotid calcification. Serum OPG concentrations were compared in 145 patients who underwent carotid sonography (average age: 68 ± 9 years old, male: female = 81:64). A calcified plaque (CP) (37 people [27%]), a noncalcified plaque (NCP) (54 people [37%]), and a nonplaque (NP) (54 people [37%]) were classified for this study. No significant differences among 3 groups were demonstrated in the distribution of age, diabetes, high blood pressure, and hyperlipidemia. Serum osteoprotegerin concentrations were significantly increased in CP group rather than NCP group or NP group; (median [interquartile range], 4016 [1410] vs 3210 [1802] pg/mL, P < 0.05 and 4016 [1410] vs 3204 [1754] pg/mL, P < 0.05). Serum osteoprotegerin concentrations did not indicate a significant difference between NCP Group or NP Group. This study had proved that patient group accompanied with carotid calcification in carotid artery disease had an increased serum OPG concentration, so it could consider that OPG plays an important function on calcification related to arteriosclerosis.
authors.affiliation: From the Department of Internal Medicine, Division of Cardiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ami
authors.initials: A
authors.lastname: Kwon
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Choi
authors.forename: Yong-Won
authors.initials: YW
authors.lastname: Choi
authors.forename: Woo-Baek
authors.initials: WB
authors.lastname: Chung
authors.forename: Chul-Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Wook-Sung
authors.initials: WS
authors.lastname: Chung
authors.forename: Man-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers; D002114:Calcinosis / Q000097:blood* / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000097:blood* / Q000000981:diagnostic imaging; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D053244:Osteoprotegerin