title: Peripapillary RNFL Thickness Changes Evaluated with Spectral Domain Optical Coherence Tomography after Uncomplicated Macular Surgery for Epiretinal Membrane.
abstract: OBJECTIVE
  To evaluate the peripapillary RNFL (p-RNFL) thickness changes after vitrectomy for epiretinal membrane (ERM). The relationship between p-RNFL thickness change and visual function was assessed.
  
  
  METHODS
  Thirty-five eyes from 35 patients with ERM who underwent vitrectomy with internal limiting membrane (ILM) removal were included. Average p-RNFL and the four quadrants thickness were measured by spectral-domain optical coherence tomography (SD-OCT) before and at one, three, and six months after surgery.
  
  
  RESULTS
  At six months after surgery, p-RNFL thickness of the temporal and inferior quadrant was decreased in the operated eyes compared with fellow eyes (p<0.05). Pattern standard deviation (PSD) was higher than that of fellow eyes (p = 0.002). The temporal and inferior quadrant p-RNFL thickness showed a relationship with both best-corrected visual acuity (BCVA) outcome and the six-month PSD (p<0.05, respectively).
  
  
  CONCLUSIONS
  The selective decrease in the temporal and inferior p-RNFL thickness after vitrectomy for ERM removal could indicate inner retinal damage related to ILM peeling.
authors.affiliation: a Department of Ophthalmology , Sapienza University, Umberto I Hospital , Rome , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gharbiya
authors.affiliation: a Department of Ophthalmology , Sapienza University, Umberto I Hospital , Rome , Italy.
authors.forename: M
authors.initials: M
authors.lastname: La Cava
authors.affiliation: a Department of Ophthalmology , Sapienza University, Umberto I Hospital , Rome , Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tortorella
authors.affiliation: a Department of Ophthalmology , Sapienza University, Umberto I Hospital , Rome , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Abbouda
authors.affiliation: a Department of Ophthalmology , Sapienza University, Umberto I Hospital , Rome , Italy.
authors.forename: J
authors.initials: J
authors.lastname: Marchiori
authors.affiliation: a Department of Ophthalmology , Sapienza University, Umberto I Hospital , Rome , Italy.
authors.forename: E
authors.initials: E
authors.lastname: D'Ambrosio
authors.affiliation: b Maria Pia Hospital , Turin , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Jacobbi
authors.affiliation: b Maria Pia Hospital , Turin , Italy.
authors.forename: F
authors.initials: F
authors.lastname: Miranti
authors.affiliation: b Maria Pia Hospital , Turin , Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ventre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019773:Epiretinal Membrane / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D011184:Postoperative Period; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D014821:Vitrectomy
keywords: Best-corrected visual acuity; epiretinal membrane; patter standard deviation; peripapillary retinal nerve fiber layer; spectralis optical coherence tomography