title: Dynamic Analysis of Changes of Protein Levels and Selected Biochemical Indices in Rat Serum in the Course of Experimental Pleurisy.
abstract: A significant role is played in inflammation by the liver, which, stimulated by inflammatory mediators, synthetizes plasma proteins with various dynamics. The purpose of these studies is to generate a detailed dynamic analysis of changes to concentrations of plasma and serum protein fractions and selected acute-phase proteins as well as nonspecific biochemical indices during the course of an induced pleurisy. The studies were conducted on female inbred Buffalo rats, which were divided into two groups: a control group (C) and an experimental group (IP) in which pleurisy was induced. In the IP group, significant changes in biochemical indices were observed between the 48th and 96th hours of pleurisy. A reduction of albumin, transferrin, urea, and creatinine concentrations was observed, while concentrations of the complement components C3 and C4, haptoglobin, and fibrinogen increased. An early increase of IL-1 was observed, while increases of IL-6 and TNF were noted in the later period. The maximum intensity of the processes described above occurred between the 72nd and 96th hours of pleurisy.
authors.affiliation: Independent Laboratory of Neurotoxicology and Environmental Diagnostics, Wroclaw Medical University, Bartla 5, 51-618, Wroclaw, Poland.
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Całkosiński
authors.affiliation: Department of Laboratory Diagnostics, 4th Military Hospital, Weigla 5, 50-981, Wroclaw, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Majda
authors.affiliation: Department of Medical Biochemistry, Wroclaw Medical University, Chałubińskiego 10, 50-368, Wroclaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Terlecki
authors.affiliation: Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114, Wroclaw, Poland. kinga.pampuch@gmail.com.
authors.forename: Kinga
authors.initials: K
authors.lastname: Gostomska-Pampuch
authors.affiliation: Department of Drugs Form Technology, Wroclaw Medical University, Borowska 211A, 50-556, Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Małolepsza-Jarmołowska
authors.affiliation: Department of Animal Nutrition and Feed Management, Wroclaw University of Environmental and Life Sciences, Chełmońskiego 38c, 51-630, Wroclaw, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Sobolewska
authors.affiliation: Independent Laboratory of Neurotoxicology and Environmental Diagnostics, Wroclaw Medical University, Bartla 5, 51-618, Wroclaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Całkosińska
authors.affiliation: Independent Laboratory of Neurotoxicology and Environmental Diagnostics, Wroclaw Medical University, Bartla 5, 51-618, Wroclaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kumala
authors.affiliation: Department of Medical Biochemistry, Wroclaw Medical University, Chałubińskiego 10, 50-368, Wroclaw, Poland.|Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114, Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gamian
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000032:analysis* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood; D010998:Pleurisy / Q000097:blood*; D051381:Rats; D011915:Rats, Inbred BUF; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000097:blood
chemical_list: D000209:Acute-Phase Proteins; D001798:Blood Proteins; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: acute-phase proteins; electrophoresis of serum proteins; inflammatory reaction; pleurisy