title: Mitochondrial function following downhill and/or uphill exercise training in rats.
abstract: The goal of this study was to compare the effects of downhill (DH), uphill (UH), and UH-DH exercise training, at the same metabolic rate, on exercise capacity and skeletal muscle mitochondrial function.
  
  
  
  Thirty-two Wistar rats were separated into a control and 3 trained groups. The trained groups exercised for 4 weeks, 5 times per week at the same metabolic rate, either in UH, DH, or combined UH-DH. Twenty-four hours after the last training session, the soleus, gastrocnemius, and vastus intermedius muscles were removed for assessment of mitochondrial respiration.
  
  
  
  Exercise training, at the same metabolic rate, improved maximal running speed without specificity for exercise modalities. Maximal fiber respiration was enhanced in soleus and vastus intermedius in the UH group only.
  
  
  
  Exercise training, performed at the same metabolic rate, improved exercise capacity, but only UH-trained rats enhanced mitochondrial function in both soleus and vastus intermedius skeletal muscle. Muscle Nerve 54: 925-935, 2016.
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
authors.forename: Anna-Isabel
authors.initials: AI
authors.lastname: Schlagowski
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|Department of Physical and Rehabilitation Medicine, University Institute of Rehabilitation Clémenceau, Strasbourg, France.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Isner-Horobeti
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|Strasbourg University, Faculty of Sport Sciences, Strasbourg, France.
authors.forename: Stéphane P
authors.initials: SP
authors.lastname: Dufour
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|Strasbourg University, Faculty of Sport Sciences, Strasbourg, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Rasseneur
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
authors.forename: Irina
authors.initials: I
authors.lastname: Enache
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lonsdorfer-Wolf
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Doutreleau
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Charloux
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Goupilleau
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bentz
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.
authors.forename: Anne Laure
authors.initials: AL
authors.lastname: Charles
authors.affiliation: Strasbourg University, Faculty of Sport Sciences, Strasbourg, France.
authors.forename: Blah Y
authors.initials: BY
authors.lastname: Kouassi
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
authors.forename: Joffrey
authors.initials: J
authors.lastname: Zoll
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.|CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Geny
authors.affiliation: Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France. favret@unistra.fr.|Strasbourg University, Faculty of Sport Sciences, Strasbourg, France. favret@unistra.fr.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Favret
mesh_terms: D000818:Animals; D042967:Electron Transport Complex I / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008928:Mitochondria / Q000502:physiology*; D018482:Muscle, Skeletal / Q000648:ultrastructure*; D010101:Oxygen Consumption; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011659:Pulmonary Gas Exchange; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D012420:Running / Q000502:physiology; D018709:Statistics, Nonparametric
chemical_list: D017382:Reactive Oxygen Species; D019344:Lactic Acid; D042967:Electron Transport Complex I
keywords: eccentric exercise; metabolic stimulation; mitochondria; reactive oxygen species; skeletal muscle; training