title: Polymeric Nanogels with Tailorable Degradation Behavior.
abstract: The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands.
authors.forename: Yinan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands.
authors.forename: Mies J
authors.initials: MJ
authors.lastname: van Steenbergen
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands.
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands.
authors.forename: Joep B
authors.initials: JB
authors.lastname: van de Dikkenberg
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands.|Department of Targeted Therapeutics, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, 7522, NB, Enschede, The Netherlands.|Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
authors.forename: Twan
authors.initials: T
authors.lastname: Lammers
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands.
authors.forename: Cornelus F
authors.initials: CF
authors.lastname: van Nostrum
authors.affiliation: Department of Targeted Therapeutics, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, 7522, NB, Enschede, The Netherlands.|Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
authors.forename: Josbert M
authors.initials: JM
authors.lastname: Metselaar
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands.
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
mesh_terms: D000818:Animals; D016923:Cell Death; D003911:Dextrans; D000067493:Dynamic Light Scattering; D061307:Human Umbilical Vein Endothelial Cells; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D051379:Mice; D046529:Microscopy, Electron, Transmission; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D003911:Dextrans; D008689:Methacrylates; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; D014867:Water; D011092:Polyethylene Glycols; C005044:hydroxyethyl methacrylate; D011094:Polyethyleneimine; C017080:blue dextran
keywords: biodegradable; crosslink density; cytocompatibility; drug delivery systems; polymeric nanogels