title: What is the impact of capsule endoscopy in the long term period?
abstract: OBJECTIVE
  To assess the clinical impact of capsule endoscopy (CE) in the long-term follow-up period in patients with obscure gastrointestinal bleeding (OGIB).
  
  
  METHODS
  One hundred and forty-one patients who applied CE for OGIB between 2009 and 2012 were retrospectively analyzed, and this cohort was then questioned prospectively. Demographic data of the patients were determined via the presence of comorbid diseases, use of non-steroidal anti-inflammatory drugs anticoagulant-antiaggregant agents, previous diagnostic tests for bleeding episodes, CE findings, laboratory tests and outcomes.
  
  
  RESULTS
  CE was performed on 141 patients because of OGIB. The capsule was retained in the upper gastrointestinal (GI) system in two of the patients, thus video monitoring was not achieved. There were 139 patients [62% male, median age: 72 years (range: 13-93 years) and a median follow-up duration: 32 mo (range: 6-82 mo)]. The overall diagnostic yield of CE was 84.9%. Rebleeding was determined in 40.3% (56/139) of the patients. The rebleeding rates of patients with positive and negative capsule results at the end of the follow-up were 46.6% (55/118) and 4.8% (1/21), respectively. In the multivariate analysis, usage of NSAIDs, anticoagulant-antiaggregant therapies (OR = 5.8; 95%CI: 1.86-18.27) and vascular ectasia (OR = 6.02; 95%CI: 2.568-14.146) in CE were detected as independent predictors of rebleeding. In the univariate analysis, advanced age, comorbidity, and overt bleeding were detected as predictors of rebleeding.
  
  
  CONCLUSIONS
  CE is a reliable method in the diagnosis of obscure GI bleeding. Negative CE correlated with a significantly lower rebleeding risk in the long-term follow-up period.
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Ormeci
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Akyuz
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Baran
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Suut
authors.initials: S
authors.lastname: Gokturk
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Tugrul
authors.initials: T
authors.lastname: Ormeci
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Binnur
authors.initials: B
authors.lastname: Pinarbasi
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Ozlem Mutluay
authors.initials: OM
authors.lastname: Soyer
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Sami
authors.initials: S
authors.lastname: Evirgen
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Akyuz
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Karaca
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Demir
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Kaymakoglu
authors.affiliation: Asli Ormeci, Filiz Akyuz, Bulent Baran, Suut Gokturk, Binnur Pinarbasi, Ozlem Mutluay Soyer, Sami Evirgen, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, 34590 Capa, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Besisik
keywords: Capsule endoscopy; Obscure gastrointestinal bleeding; Rebleeding; Small bowel