title: [A comparison analysis of the use of intravenous β-interferon-1a 30 mcg and subcutaneous β-interferon-1a 44 mcg in routine clinical practice of treatment in patients with multiple sclerosis].
abstract: OBJECTIVE
  to compare the results of treatment of multiple sclerosis (MS) with genfaxon, cinnovex and rebif.
  
  
  METHODS
  The drugs were used in the treatment of 80 patients of the Moscow West administrative okrug during 2014-2015. Thirty patients were treated with genfaxon, 20 with cinnoVex and 30 with the original drug rebif.
  
  
  CONCLUSIONS
  Twenty-five percent of patients treated with cinnoVex were withdrawn from the study due to the non-efficacy (mean frequency of relapses was the same before and after treatment). A significant decrease of relapses was noted in patients treated with genfaxon. The high frequency of side-effects was the major problem in the treatment withgenfaxon. Due to this reason, some patients stopped treatment.A significant decrease of relapses was noted in patients treated with rebif though aversive effects were frequent during the first year of treatment. The effects of biosimilars found in this study are in line with earlier reports. Therefore, the increase of the quality of interferon-beta-1a biosimilars used for MS treatment is needed.
authors.affiliation: City Clinical Hospital #71, Moscow; Pirogov Russian Nationzl Research Medical University, Moscow.
authors.forename: O G
authors.initials: OG
authors.lastname: Borets
authors.affiliation: City Clinical Hospital #71, Moscow.
authors.forename: N F
authors.initials: NF
authors.lastname: Govorukhina
authors.affiliation: City Clinical Hospital #71, Moscow.
authors.forename: K V
authors.initials: KV
authors.lastname: Zverev
authors.affiliation: Pirogov Russian Nationzl Research Medical University, Moscow.
authors.forename: A N
authors.initials: AN
authors.lastname: Boiko
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D061605:Administration, Intravenous; D059451:Biosimilar Pharmaceuticals; D006801:Humans; D000068556:Interferon beta-1a / Q000627:therapeutic use*; D009031:Moscow; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D000276:Adjuvants, Immunologic; D059451:Biosimilar Pharmaceuticals; D000068556:Interferon beta-1a