title: The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?
abstract: Small leucine-rich proteoglycans are emerging as important regulatory proteins within the extracellular matrix, where they exert both structural and nonstructural functions and hence are modulators of numerous biological processes, such as inflammation, fibrosis, and cell proliferation. One proteoglycan in particular, osteoglycin (OGN), also known as mimecan, shows great structural and functional diversity in normal physiology and in disease states, therefore making it a very interesting candidate for the development of novel therapeutic strategies. Unfortunately, the literature on OGN is confusing, as it has different names, and different transcript and protein variants have been identified. This review will give a clear overview of the different structures and functions of OGN that have been identified to date, portray its central role in pathophysiology, and highlight the importance of posttranslational processing, such as glycosylation, for the diversity of its functions.-Deckx, S., Heymans, S., Papageorgiou, A.-P. The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?
authors.affiliation: Department of Cardiology, Maastricht University, Maastricht, The Netherlands; and Center for Molecular and Vascular Biology, Katholieke Universiteit (KU) Leuven, Leuven, Belgium s.deckx@maastrichtuniversity.nl.
authors.forename: Sophie
authors.initials: S
authors.lastname: Deckx
authors.affiliation: Department of Cardiology, Maastricht University, Maastricht, The Netherlands; and Center for Molecular and Vascular Biology, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
authors.forename: Stephane
authors.initials: S
authors.lastname: Heymans
authors.affiliation: Department of Cardiology, Maastricht University, Maastricht, The Netherlands; and Center for Molecular and Vascular Biology, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
authors.forename: Anna-Pia
authors.initials: AP
authors.lastname: Papageorgiou
mesh_terms: D005109:Extracellular Matrix / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C063488:OGN protein, human
keywords: SLRPs; glycosylation; matrix