title: Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update.
abstract: The aim of this article is to provide an overview of clinical and translational research on intradiscal platelet-rich plasma (PRP) as a minimally invasive treatment for discogenic low back pain.
  
  
  
  A literature review of in vitro, in vivo, and clinical studies was performed.
  
  
  
  There is strong in vitro evidence that supports the use of intradiscal PRP for discogenic low back pain. There are also promising findings in select preclinical animal studies. A clinical study of 29 participants who underwent intradiscal PRP injections for discogenic low back pain found statistically and clinically significant improvements in pain and function through two years of follow-up.
  
  
  
  Intradiscal PRP is a safe and a possibly effective treatment for discogenic low back pain. Future studies are warranted to determine the best candidates for this treatment, what the optimal injectate is and what relationships exist between patient-reported outcomes and radiological findings.
authors.affiliation: Department of Physiatry, Hospital for Special Surgery, 429 E 75th Street, 3rd Floor, New York, NY, 10021, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Monfett
authors.affiliation: Department of Physiatry, Hospital for Special Surgery, 429 E 75th Street, 3rd Floor, New York, NY, 10021, USA.
authors.forename: Julian
authors.initials: J
authors.lastname: Harrison
authors.affiliation: Department of Physiatry, Hospital for Special Surgery, 429 E 75th Street, 3rd Floor, New York, NY, 10021, USA.
authors.forename: Kwadwo
authors.initials: K
authors.lastname: Boachie-Adjei
authors.affiliation: Department of Physiatry, Hospital for Special Surgery, 429 E 75th Street, 3rd Floor, New York, NY, 10021, USA. lutzg@hss.edu.
authors.forename: Gregory
authors.initials: G
authors.lastname: Lutz
mesh_terms: D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000187:drug effects*; D055959:Intervertebral Disc Degeneration / Q000150:complications / Q000188:drug therapy*; D007405:Intervertebral Disc Displacement / Q000188:drug therapy; D017116:Low Back Pain / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D053657:Platelet-Rich Plasma / Q000187:drug effects*; D016896:Treatment Outcome
keywords: Biologic; Disc; Treatments