title: Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase.
abstract: Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that an NAD-dependent glutamate dehydrogenase (GdhZ) coordinates growth with cell division according to its enzymatic activity. Here we report the conserved role of GdhZ in controlling cell division in another α-proteobacterium, the facultative intracellular pathogen Brucella abortus. We also discuss the importance of amino acids as a main carbon source for α-proteobacteria.
authors.affiliation: Bacterial Cell cycle & Development (BCcD), URBM, University of Namur , Namur, Belgium.
authors.forename: François
authors.initials: F
authors.lastname: Beaufay
authors.affiliation: Bacterial Cell cycle & Development (BCcD), URBM, University of Namur , Namur, Belgium.
authors.forename: Xavier
authors.initials: X
authors.lastname: De Bolle
authors.affiliation: Bacterial Cell cycle & Development (BCcD), URBM, University of Namur , Namur, Belgium.
authors.forename: Régis
authors.initials: R
authors.lastname: Hallez
keywords: Brucella; Caulobacter; FstZ; GdhZ; cell division; cytokinesis; glutamate dehydrogenase; α-proteobacteria