title: Overview of Management of Myocardial Ischemia: a Mechanistic-Based Approach.
abstract: Pharmacologic treatment of myocardial ischemia in patients with chronic stable angina (CSA) is mainly based on heart rate lowering drugs and vasodilator agents. Other drugs are available, however, that act by some peculiar mechanism (ranolazine, trimetazidine) and may add potential anti-ischemic and anti-anginal effects to standard therapeutic mechanisms. While anti-ischemic agents are crucial for controlling angina symptoms and improving quality of life, whether myocardial ischemia portends an ominous prognosis and its suppression improves clinical outcome in CSA patients remain debated issues.
authors.affiliation: Institute of Cardiology, Università Cattolice del Sacro Cuore, Policlinico A. Gemelli, Largo A. Gemelli, 8, 00168, Roma, Italy. gaetanoantonio.lanza@unicatt.it.
authors.forename: Gaetano Antonio
authors.initials: GA
authors.lastname: Lanza
authors.affiliation: Institute of Cardiology, Università Cattolice del Sacro Cuore, Policlinico A. Gemelli, Largo A. Gemelli, 8, 00168, Roma, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
mesh_terms: D002317:Cardiovascular Agents / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D002317:Cardiovascular Agents
keywords: Angina; Clinical outcome; Medical therapy; Myocardial ischemia; Pathophysiologic mechanisms