title: Effect of carboxymethylation on rheological and drug release characteristics of locust bean gum matrix tablets.
abstract: This study was undertaken to investigate correlation between the carboxymethylation-induced rheological changes and drug release characteristics of locust bean gum (LBG) matrix tablets. LBG was derivatized to carboxymethyl LBG (CMLBG) and characterized by (13)C NMR, FTIR and elemental analyses. Rheological studies revealed that LBG, in contact with water, produced a strong elastic gel which swelled less due to lower penetration of water resulting in slower drug release. On the other hand, CMLBG formed a viscous polymer solution through which higher influx of water resulted in rapid swelling of the matrix and faster drug release. Although the release from a particular matrix was dependent on drugs' solubilities, CMLBG matrix tablet produced faster release of all the drugs than LBG matrix tablets. In conclusion, rheological study appeared to be an useful tool to predict release of drugs from polysaccharide matrix tablets.
authors.affiliation: Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. Electronic address: amrita.fultu@gmail.com.
authors.forename: Amrita
authors.initials: A
authors.lastname: Chakravorty
authors.affiliation: Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. Electronic address: gourangabmn@gmail.com.
authors.forename: Gouranga
authors.initials: G
authors.lastname: Barman
authors.affiliation: Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. Electronic address: sudipta07tech@gmail.com.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. Electronic address: biswanathsa2003@yahoo.com.
authors.forename: Biswanath
authors.initials: B
authors.lastname: Sa
mesh_terms: D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry*; D000478:Alkylation; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D065546:Drug Liberation; D007887:Fabaceae / Q000737:chemistry*; D005685:Galactans / Q000138:chemical synthesis / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D008351:Mannans / Q000138:chemical synthesis / Q000737:chemistry*; D008795:Metronidazole / Q000737:chemistry; D053149:Plant Gums / Q000138:chemical synthesis / Q000737:chemistry*; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity
chemical_list: D000085:Acetates; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D008795:Metronidazole; C017471:locust bean gum; D007052:Ibuprofen
keywords: Carboxymethylation; Drug release; Locust bean gum; Rheology