title: Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
abstract: Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3'-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a β-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana, 46556, USA. ; Tel: +1 574 631 7571.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana, 46556, USA. ; Tel: +1 574 631 7571.
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Miller
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana, 46556, USA. ; Tel: +1 574 631 7571.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Wencewicz
authors.affiliation: Leibniz Institute for Natural Products Research and Infection Biology - Hans Knöell Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
authors.forename: Ute
authors.initials: U
authors.lastname: Möollmann