title: A Multifunctional PB@mSiO2-PEG/DOX Nanoplatform for Combined Photothermal-Chemotherapy of Tumor.
abstract: In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@mSiO2-PEG nanocubes. The PB@mSiO2-PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO2-PEG nanocubes, the constructured PB@mSiO2-PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO2-PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Yun Yan
authors.initials: YY
authors.lastname: Su
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Teng
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Drum Tower Hospital, Medical School of Nanjing University , Nanjing 210008, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yao
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Shou Ju
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Yun Lei
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Wen Fei
authors.initials: WF
authors.lastname: Liu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Li Juan
authors.initials: LJ
authors.lastname: Zheng
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Lu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Qian Qian
authors.initials: QQ
authors.lastname: Ni
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications , Nanjing 210046, People's Republic of China.
authors.forename: Xiao Dan
authors.initials: XD
authors.lastname: Su
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Yu Xia
authors.initials: YX
authors.lastname: Tang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Gui Fen
authors.initials: GF
authors.lastname: Yang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Guang Ming
authors.initials: GM
authors.lastname: Lu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
authors.forename: Long Jiang
authors.initials: LJ
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents; D004317:Doxorubicin; D006801:Humans; D049329:Nanostructures; D009369:Neoplasms; D010789:Phototherapy; D011092:Polyethylene Glycols; D012822:Silicon Dioxide
chemical_list: D000970:Antineoplastic Agents; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: Prussian blue; magnetic resonance imaging; mesoporous silica; photoacoustic tomography; photothermo−chemotherapy