title: Biomedical therapy using synthetic WKYMVm hexapeptide.
abstract: WKYMVm hexapeptide has been identified as a strong FPR2 agonist through a library screening of synthetic peptides. The FPR2 has been reported to play a crucial role in inflammation and angiogenic responses via stimulation of chemotaxis, migration, cell proliferation, wound healing and vessel growth. Recently, the therapeutic effects of WKYMVm have been reported in various disease models. In cutaneous wound model in diabetic mice, WKYMVm facilitated wound healing processes by stimulating the formation of capillary and arteriole and re-epithelialization. In coronary artery stenosis model, WKYMVm coating on stent promoted re-endothelialization and lowered restenosis rate. In hindlimb ischemia mouse model, intramuscular injection of WKYMVm promoted homing of exogenously transplanted endothelial colony-forming cells and neovascularization, resulting in salvaging hindlimb. Furthermore, a single injection of WKYMVm encapsulated in poly (lactide-co-glycolide) microspheres was demonstrated to be as efficient as multiple injections of WKYMVm in restoring blood flow in hindlimb ischemia model. These observations may open up promising biomedical applications of WKYMVm for tissue repairs and regenerations.
authors.affiliation: a School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University , Seoul , Republic of Korea.
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Choi
authors.affiliation: b Department of Physiology , School of Medicine, Pusan National University Yangsan Hospital , Yangsan , Republic of Korea.
authors.forename: Il Ho
authors.initials: IH
authors.lastname: Jang
authors.affiliation: b Department of Physiology , School of Medicine, Pusan National University Yangsan Hospital , Yangsan , Republic of Korea.
authors.forename: Soon Chul
authors.initials: SC
authors.lastname: Heo
authors.affiliation: b Department of Physiology , School of Medicine, Pusan National University Yangsan Hospital , Yangsan , Republic of Korea.|c Research Institute of Convergence Biomedical Science and Technology , Yangsan , Gyeongsangnam-do , Republic of Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: a School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University , Seoul , Republic of Korea.|d N-Bio Institute , Seoul National University , Seoul , Republic of Korea.
authors.forename: Nathaniel S
authors.initials: NS
authors.lastname: Hwang
mesh_terms: D000818:Animals; D023903:Coronary Restenosis / Q000188:drug therapy; D006801:Humans; D007511:Ischemia / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology; D015607:Stents; D014945:Wound Healing / Q000187:drug effects
chemical_list: D009842:Oligopeptides; C113617:Trp-Lys-Tyr-Met-Val-Met
keywords: WKYMVm; angiogenesis; anti-restenosis; formyl peptide receptor-2; neovascularization; re-endothelialization; wound healing