title: Dialyzer-related Thrombocytopenia due to a Polysulfone Membrane.
abstract: A 72-year-old Japanese woman was admitted to our hospital with rapidly progressive glomerulonephritis associated with anti-glomerular basement membrane antibody. Hemodialysis (HD) therapy was initiated on the day of admission using a biocompatible polysulfone (PS) membrane. Her platelet count (PLT; ×10(4)/μL) decreased gradually from 58.7 (day 1) to 5.8 (day 25). Considering the possibility of dialyzer-related thrombocytopenia (DRT), we measured her PLT count before and after the HD session on day 72, which revealed a dramatic decrease of 7.5 to 4.3. This finding suggested that the PS dialyzer caused PLT depletion. After discontinuation of the PS dialyzer, DRT was resolved.
authors.affiliation: Dialysis Center, Fukushima Medical University Hospital, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Kobari
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Terawaki
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kusano
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sakurai
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Naotaro
authors.initials: N
authors.lastname: Fukushima
authors.forename: Sawako
authors.initials: S
authors.lastname: Suzuki
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakayama
mesh_terms: D000368:Aged; D001672:Biocompatible Materials; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy; D006470:Hemorrhage / Q000628:therapy; D006801:Humans; D008171:Lung Diseases / Q000628:therapy; D008567:Membranes, Artificial; D010976:Platelet Count; D011108:Polymers / Q000009:adverse effects*; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods; D013450:Sulfones / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700