title: Fabrication and Operation of Paper-Based Analytical Devices.
abstract: This review focuses on the fabrication techniques and operational components of microfluidic paper-based analytical devices (μPADs). Being low-cost, user-friendly, fast, and simple, μPADs have seen explosive growth in the literature in the last decade. Many different materials and technologies have been employed to fabricate μPADs for various applications, including those that employ patterning, the creation of physical boundaries, and three-dimensional structures. In addition to fabrication techniques, flow control and other operational components in μPADs are of great interest. These components enable μPADs to control flow rates, direct flow paths via valves, sequentially deliver reagents automatically, and display test results, all of which will make μPADs more suitable for point-of-care applications.
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611; email: hfan@ufl.edu.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jiang
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611; email: hfan@ufl.edu.|Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611.|Department of Chemistry, University of Florida, Gainesville, Florida 32611.
authors.forename: Z Hugh
authors.initials: ZH
authors.lastname: Fan
keywords: electrochemical detection; flow control; lamination; microfluidics; point of care; μPADs