title: Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels.
abstract: Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth cohort. Spearman correlations were examined within subgroups defined by prenatal and delivery factors. Cord blood as a percentage of prenatal 25(OH)D level was calculated and characteristics compared between those who did and did not have ≥25% and ≥50% of the maternal level and those who did and did not have a detectable 25(OH)D level. The correlation among Black children was lower than in White children. When the maternal 25(OH)D level was <15 ng/mL, the overall correlation was r = 0.16. Most children had a 25(OH)D cord blood level less than half of their mother's; 15.4% had a level that was <25% of their mother's. Winter birth and maternal level were associated with the level being less than 25%. Children with undetectable levels were more likely to be Black and less likely to be firstborn. These data suggest mothers may reduce their contribution to the fetus's 25(OH)D supply once their own level becomes low.
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Ganesa
authors.initials: G
authors.lastname: Wegienka
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Hareena
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Department of Women's Health, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Roopina
authors.initials: R
authors.lastname: Sangha
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Cassidy-Bushrow
mesh_terms: D000328:Adult; D001741:Black or African American; D002762:Cholecalciferol / Q000097:blood; D015331:Cohort Studies; D004872:Ergocalciferols / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D008824:Michigan; D009765:Obesity / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011263:Pregnancy Trimester, Third; D012621:Seasons; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*; D044465:White People; D055815:Young Adult
chemical_list: D004872:Ergocalciferols; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D