title: The role of phosphatidylinositol-transfer proteins at membrane contact sites.
abstract: Phosphatidylinositol-transfer proteins (PITPs) have been initially identified as soluble factors that accelerate the monomeric exchange of either phosphatidylinositol (PI) or phosphatidylcholine (PC) between membrane bilayersin vitro They are highly conserved in eukaryotes and have been implicated in different cellular processes, including vesicular trafficking, signal transduction, and lipid metabolism. Recent studies suggest that PITPs function at membrane contact sites (MCSs) to facilitate the transport of PI from its synthesis site at the endoplasmic reticulum (ER) to various membrane compartments. In this review, we describe the underlying mechanism of PITPs targeting to MCSs, discuss their cellular roles and potential mode of action.
authors.affiliation: Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Selitrennik
authors.affiliation: Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot 76100, Israel Sima.Lev@weizmann.ac.il.
authors.forename: Sima
authors.initials: S
authors.lastname: Lev
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D010716:Phosphatidylinositols / Q000378:metabolism; D049294:Phospholipid Transfer Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding; D011487:Protein Conformation; D015398:Signal Transduction
chemical_list: D010716:Phosphatidylinositols; D049294:Phospholipid Transfer Proteins
keywords: PI-transfer proteins; lipid transfer; membrane contact sites; phosphoinositides; signaling