title: Quantitative evaluation of striated muscle injury by multiscale blob features method.
abstract: OBJECTIVE
  This study aimed to use the multiscale blob feature (MBF) method to quantitatively evaluate porcine striated muscle injuries.
  
  
  METHODS
  A porcine striated muscle injury model was induced by microwave ablation and anhydrous acetic acid injection, respectively. Then, both 2D sonographic and histological features of the lesions were recorded and compared. Later, MBF was used to quantitatively evaluate the porcine striated muscle injuries by extracting the texture features from the 2D ultrasonogram via measuring eight textural parameters (Mean, SDev, NOB, [Formula: see text], [Formula: see text], HOD, DOD, and POD).
  
  
  RESULTS
  Microwave ablation produced oval or round-like lesions, which had a pale gray color, with an echo attenuation detected at lesion center due to carbonization; anhydrous acetic acid injection produced long, stripped lesions, which had a slate-gray color, with a gas-like intense echo at lesion center. There were significant differences in Mean, [Formula: see text] and POD between the muscle samples treated by microwave ablation and the control samples, as well as significant differences in NOB, [Formula: see text] and POD between the muscle samples treated by anhydrous acetic acid injection and the control. There were significant differences in Mean, [Formula: see text], NOB, and [Formula: see text] between the muscle samples treated by microwave ablation and those treated by anhydrous acetic acid injection.
  
  
  CONCLUSIONS
  Quantitative evaluation of striated muscle injuries using the MBF method was able to differentiate the muscle injuries caused by microwave ablation and anhydrous acetic acid injection, suggesting that this method may be a potential and reliable tool for quantitative evaluation of muscle injuries.
authors.affiliation: Department of Ultrasound, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Ultrasound, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. wintersnow9090@sina.com.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Computer Science, Institute of Information Engineering, Shanghai Maritime University, Shanghai, 201306, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Ultrasound, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Department of Ultrasound, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
authors.forename: Zongping
authors.initials: Z
authors.lastname: Diao
authors.affiliation: Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. cjrliushiyuan@vip.163.com.
authors.forename: Shiyuan
authors.initials: S
authors.lastname: Liu
mesh_terms: D019342:Acetic Acid; D000818:Animals; D004195:Disease Models, Animal; D008872:Microwaves; D054792:Muscle, Striated / Q000000981:diagnostic imaging* / Q000293:injuries*; D013552:Swine
chemical_list: D019342:Acetic Acid
keywords: Anhydrous acetic acid injection; Microwave ablation; Multiscale blob features; Quantitative ultrasonography; Striated muscle injury