title: Evidence for an intrinsic binding force between dodecaborate dianions and receptors with hydrophobic binding pockets.
abstract: A gas phase binding study revealed strong intrinsic intermolecular interactions between dianionic halogenated closo-dodecaborates [B12X12](2-) and several neutral organic receptors. Oxidation of a tetrathiafulvalene host allowed switching between two host-guest binding modes in a supramolecular complex. Complexes of β-cyclodextrin with [B12F12](2-) show remarkable stability in the gas phase and were successfully tested as carriers for the delivery of boron clusters into cancer cells.
authors.affiliation: Universität Bremen, Institut für Angewandte und Physikalische Chemie, Leobener Str. NW 2, D-28334 Bremen, Germany. jonas.warneke@uni-bremen.de vazov@uni-bremen.de.
authors.forename: Jonas
authors.initials: J
authors.lastname: Warneke
authors.forename: Carsten
authors.initials: C
authors.lastname: Jenne
authors.forename: Johannes
authors.initials: J
authors.lastname: Bernarding
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Azov
authors.forename: Markus
authors.initials: M
authors.lastname: Plaumann
mesh_terms: D000838:Anions / Q000737:chemistry; D001665:Binding Sites; D001896:Boron Compounds / Q000737:chemistry / Q000494:pharmacology*; D016754:Boron Neutron Capture Therapy; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010084:Oxidation-Reduction
chemical_list: D000838:Anions; D001896:Boron Compounds; D004337:Drug Carriers; D006571:Heterocyclic Compounds; C119788:dodecaborate; C063887:tetrathiafulvalene