title: Magnetically and Near-Infrared Light-Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions.
abstract: Cancer is one of the primary causes of death worldwide. A high-precision analysis of biomolecular behaviors in cancer cells at the single-cell level and more effective cancer therapies are urgently required. Here, we describe the development of a magnetically- and near infrared light-triggered optical control method, based on nanorobotics, for the analyses of cellular functions. A new type of nanotransporters, composed of magnetic iron nanoparticles, carbon nanohorns, and liposomes, was synthesized for the spatiotemporal control of cellular functions in cells and mice. Our technology will help to create a new state-of-the-art tool for the comprehensive analysis of "real" biological molecular information at the single-cell level, and it may also help in the development of innovative cancer therapies.
authors.affiliation: Nanomaterial Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, 305-8565, Japan.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Chechetka
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yuba
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kono
authors.affiliation: Nanomaterial Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, 305-8565, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Yudasaka
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 15 Rue René Descartes, 67084, Strasbourg, France.
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
authors.affiliation: Nanomaterial Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, 305-8565, Japan. e-miyako@aist.go.jp.
authors.forename: Eijiro
authors.initials: E
authors.lastname: Miyako
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology*; D046911:Macromolecular Substances / Q000737:chemistry / Q000494:pharmacology; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D008081:Liposomes; D046911:Macromolecular Substances; D058185:Magnetite Nanoparticles; D037742:Nanotubes, Carbon; D001616:beta-Galactosidase
keywords: carbon nanohorns; drug delivery systems; liposomes; magnetic nanoparticles; nanorobots