title: Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development.
abstract: All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we have divided LMPPs into CD127(-) (LMPP-s) and CD127(+) (LMPP+s) subsets and compared them with Ly6D(-) and Ly6D(+) CLPs. Adult LMPP+s differentiated into T cells and ILCs more rapidly and efficiently than other progenitors in transplantation assays. The development of T cells and ILC2s is highly active in the neonatal period. Neonatal CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into T cells and ILC2s. ILC2s generated in the neonatal period are long lived and persist in adult tissues. These results suggest that some ILCs and T cells may develop from LMPP+s via CLP-independent pathways.
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghaedi
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Interdisciplinary Oncology Program, University of British Columbia, Vancouver, BC V6T 1Z2, Canada.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Steer
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
authors.forename: Itziar
authors.initials: I
authors.lastname: Martinez-Gonzalez
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada.
authors.forename: Timotheus Y F
authors.initials: TYF
authors.lastname: Halim
authors.affiliation: Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
authors.forename: Ninan
authors.initials: N
authors.lastname: Abraham
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada. Electronic address: ftakei@bccrc.ca.
authors.forename: Fumio
authors.initials: F
authors.lastname: Takei
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001853:Bone Marrow / Q000378:metabolism; D019070:Cell Lineage; D020869:Gene Expression Profiling; D007113:Immunity, Innate; D008168:Lung / Q000166:cytology; D016131:Lymphocyte Subsets / Q000166:cytology / Q000378:metabolism; D054503:Lymphoid Progenitor Cells / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D015398:Signal Transduction; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism*