title: The effects of cold atmospheric plasma on cell adhesion, differentiation, migration, apoptosis and drug sensitivity of multiple myeloma.
abstract: Cold atmospheric plasma was shown to induce cell apoptosis in numerous tumor cells. Recently, some other biological effects, such as induction of membrane permeation and suppression of migration, were discovered by plasma treatment in some types of tumor cells. In this study, we investigated the biological effects of plasma treatment on multiple myeloma cells. We detected the detachment of adherent myeloma cells by plasma, and the detachment area was correlated with higher density of hydroxyl radical in the gas phase of the plasma. Meanwhile, plasma could promote myeloma differentiation by up-regulating Blimp-1 and XBP-1 expression. The migration ability was suppressed by plasma treatment through decreasing of MMP-2 and MMP-9 secretion. In addition, plasma could increase bortezomib sensitivity and induce myeloma cell apoptosis. Taking together, combination with plasma treatment may enhance current chemotherapy and probably improve the outcomes.
authors.affiliation: State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China; Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China. Electronic address: dehuixu@hotmail.com.
authors.forename: Dehui
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Urinary Surgery, Central Hospital of Baoji, Bao Ji City, Shaanxi 721000, PR China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China; Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China; Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of the Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China; Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China.
authors.forename: Dingxin
authors.initials: D
authors.lastname: Liu
authors.affiliation: Frank Reidy Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA.
authors.forename: Hailan
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China; Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China; Frank Reidy Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA; Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23529, USA. Electronic address: mkong@odu.edu.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Kong
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D000069286:Bortezomib / Q000627:therapeutic use; D002448:Cell Adhesion / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D058626:Plasma Gases / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D058626:Plasma Gases; D000069286:Bortezomib
keywords: Apoptosis; Cold atmospheric plasma; Differentiation; Drug sensitivity; Migration; Myeloma