title: Illuminating the physiology of extracellular vesicles.
abstract: Extracellular vesicles play a crucial role in intercellular communication by transmitting biological materials from donor cells to recipient cells. They have pathophysiologic roles in cancer metastasis, neurodegenerative diseases, and inflammation. Extracellular vesicles also show promise as emerging therapeutics, with understanding of their physiology including targeting, distribution, and clearance therefore becoming an important issue. Here, we review recent advances in methods for tracking and imaging extracellular vesicles in vivo and critically discuss their systemic distribution, targeting, and kinetics based on up-to-date evidence in the literature.
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon-Dong, Jongno-Gu, Seoul, 110-744, South Korea.|Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Gwanak _599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, South Korea.
authors.forename: Hongyoon
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon-Dong, Jongno-Gu, Seoul, 110-744, South Korea. dsl@plaza.snu.ac.kr.|Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Gwanak _599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, South Korea. dsl@plaza.snu.ac.kr.|College of Medicine or College of Pharmacy, Seoul National University, Gwanak _599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, South Korea. dsl@plaza.snu.ac.kr.
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
mesh_terms: D001692:Biological Transport; D002450:Cell Communication; D000067128:Extracellular Vesicles / Q000637:transplantation* / Q000648:ultrastructure; D005290:Ferric Compounds / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D007205:Indium Radioisotopes; D007249:Inflammation / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D061848:Optical Imaging; D011877:Radionuclide Imaging / Q000379:methods
chemical_list: D005290:Ferric Compounds; D005456:Fluorescent Dyes; D007205:Indium Radioisotopes; D058185:Magnetite Nanoparticles; C000499:ferric oxide
keywords: Exosome; Extracellular vesicle; Imaging; In vivo distribution; Microvesicle