title: Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment.
abstract: Ocular hypertension is a major risk factor for the development and progression of glaucoma. Frequent and long-term application of latanoprost often causes undesirable local side effects, which are a major cause of therapeutic failure due to loss of persistence in using this glaucoma medical therapy. In the present study, we developed a thermosensitive chitosan-based hydrogel as a topical eye drop formulation for the sustained release of latanoprost to control ocular hypertension. The developed formulation without preservatives may improve compliance and possibly even efficacy. The results of this study support its biocompatibility and sustained-release profile both in vitro and in vivo. After topical application of latanoprost-loaded hydrogel, triamcinolone acetonide-induced elevated intraocular pressure was significantly decreased within 7 days and remained at a normal level for the following 21 days in rabbit eyes. This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment.
authors.affiliation: Department of Education and Research, Taipei City Hospital, No.145, Zhengzhou Rd., Datong Dist., Taipei, Taiwan; Department and Institute of Pharmacology, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan. Electronic address: yunghsin@ym.edu.tw.
authors.forename: Yung-Hsin
authors.initials: YH
authors.lastname: Cheng
authors.affiliation: Department of Education and Research, Taipei City Hospital, No.145, Zhengzhou Rd., Datong Dist., Taipei, Taiwan; Institute of Traditional Medicine, National Yang-Ming University, No.155, Sec. 2, Linong Street, Taipei 112, Taiwan. Electronic address: thtsai@ym.edu.tw.
authors.forename: Tung-Hu
authors.initials: TH
authors.lastname: Tsai
authors.affiliation: Department and Institute of Pharmacology, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan. Electronic address: k45204113@hotmail.com.
authors.forename: Yong-Yu
authors.initials: YY
authors.lastname: Jhan
authors.affiliation: National Yang-Ming University School of Medicine, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan. Electronic address: whchiu@ym.edu.tw.
authors.forename: Allen Wen-hsiang
authors.initials: AW
authors.lastname: Chiu
authors.affiliation: Department of Physical Therapy, College of Medicine, National Cheng Kung University,No. 1, University Road, Tainan City 701, Taiwan. Electronic address: kunlingtsai@mail.ncku.edu.tw.
authors.forename: Kun-Ling
authors.initials: KL
authors.lastname: Tsai
authors.affiliation: Department and Institute of Pharmacology, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan. Electronic address: polo661124@yahoo.com.tw.
authors.forename: Chian-Shiu
authors.initials: CS
authors.lastname: Chien
authors.affiliation: Department and Institute of Pharmacology, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 112, Taiwan. Electronic address: shchiou@vghtpe.gov.tw.
authors.forename: Shih-Hwa
authors.initials: SH
authors.lastname: Chiou
authors.affiliation: National Yang-Ming University School of Medicine, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 112, Taiwan. Electronic address: jlliu@vghtpe.gov.tw.
authors.forename: Catherine Jui-lin
authors.initials: CJ
authors.lastname: Liu
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism; D048271:Chitosan / Q000737:chemistry* / Q000633:toxicity; D003315:Cornea / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D020100:Hydrogels / Q000737:chemistry*; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008422:Materials Testing; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D013696:Temperature
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D048271:Chitosan
keywords: Chitosan; Glaucoma; Latanoprost; Sustained release