title: In experimental chronic kidney disease or cancer, parathyroid hormone is a novel mediator of cachexia.
abstract: Hyperparathyroidism plays a central role in the disordered bone mineral metabolism of chronic kidney disease, and has been associated with increased cardiovascular morbidity and mortality in that setting. A recent study suggests a novel role for parathyroid hormone and its receptor in muscle wasting and cachexia occurring in advanced chronic kidney disease.
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Wyatt
authors.affiliation: Selzman Institute for Kidney Health, Baylor College of Medicine, Department of Medicine, Houston, Texas, USA. Electronic address: mitch@bcm.edu.
authors.forename: William E
authors.initials: WE
authors.lastname: Mitch
mesh_terms: D001842:Bone and Bones; D002100:Cachexia; D002908:Chronic Disease; D006801:Humans; D006962:Hyperparathyroidism, Secondary; D009369:Neoplasms; D010281:Parathyroid Hormone; D051436:Renal Insufficiency, Chronic
chemical_list: D010281:Parathyroid Hormone