title: [The influence of porcelain-fused-to-metal on the expression level of IL-23 in gingival crevicular fluid].
abstract: OBJECTIVE
  To investigate the role of IL-23 in the pathogenesis of periodontitis, and the influence of porcelain-fused-to-metal (PFM) on periodontal tissue and the expression level of IL-23.
  
  
  METHODS
  The gingival crevicular fluid (GCF) samples were collected in 10 periodontally healthy individuals, 14 cases with gingivitis, 14 cases with gingivitis and PFM, and 14 cases with periodontitis and PFM. The teeth were detected and recorded the clinical parameters（GI, SBI, AL, PD）by Florida probe. The concentration of IL-23 in GCF was detected by ELISA assays.SPSS13.0 software package was used for statistical analysis.
  
  
  RESULTS
  The expression of IL-23 in GCF of normal group (227.047±29.880) pg/mL was below inflammatory groups. A significant overexpression of IL-23 in GCF was detected in periodontitis with PFM group(511.327±138.846) pg/mL compared to gingivitis group (330.353±196.266) pg/mL (P<0.01) and gingivitis with PFM group (347.359±218.260) pg/mL (P<0.05). The expression level of IL-23 in GCF was positively correlated with clinical parameters (GI, SBI, AL, PD) (r>0.4, P<0.05). There was a high degree of periodontal destruction in gingivitis with PFM group compared to gingivitis group, and significant difference existed in AL (P<0.05) and PD (P<0.01). The change of IL-23 expression was most positively correlated with PD (r>0.5, P<0.01).
  
  
  CONCLUSIONS
  IL-23 might play an important role in the pathogenesis of periodontitis. PFM could have influence on the destruction of periodontal tissues and the expression level of IL-23.
authors.affiliation: Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China. E-mail:124033104@qq.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China.
authors.forename: Ke-bei
authors.initials: KB
authors.lastname: Gao
authors.affiliation: Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Lin
mesh_terms: D003776:Dental Porcelain; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D005891:Gingivitis; D006801:Humans; D053759:Interleukin-23 / Q000378:metabolism*; D008670:Metals; D010518:Periodontitis; D010519:Periodontium
chemical_list: D053759:Interleukin-23; D008670:Metals; D003776:Dental Porcelain