title: A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5.
abstract: A new macrolactin derivate, 7-O-2'E-butenoyl macrolactin A (1), together with three known macrolactin compounds, macrolactin A (2), 7-O-malonyl macrolactin A (3) and 7-O-succinyl macrolactin A (4), was isolated from the bacterial strain Bacillus subtilis B5, which was isolated from the 3000 m deep sea sediment of the Southwest Pacific Ocean. The structures of the new compounds were assigned by spectroscopic methods including 1-D/2-D NMR and MS analysis techniques. Compounds 1 and 2 demonstrated antifungal activities against tea pathogenic fungi Pestalotiopsis theae and Colletotrichum gloeosporioides.
authors.affiliation: a School of Life Science and Biopharmaceutical , Shenyang Pharmaceutical University , Shenyang , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: c Key Laboratory of Marine Biogenetic Resources , The Third Institute of Oceanography, The State Oceanic Administration , Xiamen , China.|d South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center , Xiamen , China.
authors.forename: Xi-Xiang
authors.initials: XX
authors.lastname: Tang
authors.affiliation: b School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yan
authors.affiliation: b School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wu
authors.affiliation: c Key Laboratory of Marine Biogenetic Resources , The Third Institute of Oceanography, The State Oceanic Administration , Xiamen , China.|d South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center , Xiamen , China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Yi
authors.affiliation: b School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Fang
authors.affiliation: a School of Life Science and Biopharmaceutical , Shenyang Pharmaceutical University , Shenyang , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Su
authors.affiliation: b School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Ying-Kun
authors.initials: YK
authors.lastname: Qiu
keywords:  B5; 7--2′-butenoyl macrolactin A; antifungal activity