title: Probabilistic evaluation of the material properties of the in vivo subject-specific articular surface using a computational model.
abstract: This article used probabilistic analysis to evaluate material properties of the in vivo subject-specific tibiofemoral (TF) joint model. Sensitivity analysis, based on a Monte Carlo (MC) method, was performed using a subject-specific finite element (FE) model generated from in vivo computed tomography (CT) and magnetic resonance imaging (MRI) data, subjected to two different loading conditions. Specifically, the effects of inherent uncertainty in ligament stiffness, horn attachment stiffness, and articular surface material properties were assessed using multifactorial global sensitivity analysis. The MRI images were taken before and after axial compression, and when the flexion condition had been maintained at up to 90 degree flexion in the subject-specific knee joint. The loading conditions of the probabilistic subject-specific FE model (axial compression and 90 degree flexion) were similar to the MRI acquisition setup. We were able to detect the influence of material parameters while maintaining the potential effect of parametric interactions. Throughout the in silico property optimization, a subject-specific FE model was used and less sensitive parameters were eliminated in the global sensitivity method. Soft tissue material properties were estimated using an optimization procedure that involved the minimization of the differences between the kinematics predicted by the subject-specific model and those obtained through in vivo subject-specific data. The results of this approach suggest that the articular surface mechanical properties could be found by using in vivo measurements, which clarifies the valuable tool for future subject-specific studies related to TF joint scaffolds, allografts and biologics. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1390-1400, 2017.
authors.affiliation: Department of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
authors.forename: Kyoung-Tak
authors.initials: KT
authors.lastname: Kang
authors.affiliation: Department of Orthopedic Surgery, Gangnam Severance Hospital, Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, 06273, Republic of Korea.
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
authors.forename: Juhyun
authors.initials: J
authors.lastname: Son
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Medical Convergence Research Institue, and Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
authors.forename: Young Han
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Orthopedic Surgery, Jeju National University Hospital, Jeju, 63241, Republic of Korea.
authors.forename: Shinil
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
authors.forename: Heoung-Jae
authors.initials: HJ
authors.lastname: Chun
mesh_terms: D000328:Adult; D006801:Humans; D021621:Imaging, Three-Dimensional; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008297:Male; D066230:Patient-Specific Modeling; D057285:Precision Medicine / Q000379:methods*; D014057:Tomography, X-Ray Computed
keywords: finite element analysis; in vivo; mechanical properties