title: [Immune cells in atherosclerosis--good or bad?].
abstract: Inflammation is a major mediator of atherosclerosis and plays a pivotal role for both innate and adaptive immunity in the onset and the progression of atherosclerosis. Novel insights into how the adaptive immune system is activated and propagates atherosclerosis elucidate the intricate interplay of different subsets of lymphocytes and their mediators as a central feature of vascular inflammation. The recognition of an inherent anti-inflammatory component of the adaptive immune system mediated by regulatory T (Treg) cells outline a novel concept: the expansion of regulatory T cells to reduce atherosclerosis. Based on a variety of research results, this concept represents a new therapeutic option in patients with atherosclerosis.
authors.affiliation: 1 Universitäres Herzzentrum, Klinik für Kardiologie, Universitätsspital Zürich.
authors.forename: Roland
authors.initials: R
authors.lastname: Klingenberg
authors.affiliation: 1 Universitäres Herzzentrum, Klinik für Kardiologie, Universitätsspital Zürich.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Matter
authors.affiliation: 1 Universitäres Herzzentrum, Klinik für Kardiologie, Universitätsspital Zürich.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Lüscher
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000906:Antibodies / Q000627:therapeutic use; D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D004730:Endothelium, Vascular / Q000276:immunology / Q000473:pathology; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D008222:Lymphokines / Q000502:physiology; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology; D017539:Tunica Intima / Q000276:immunology / Q000473:pathology
chemical_list: D000906:Antibodies; D006360:Heat-Shock Proteins; D008222:Lymphokines
keywords: Atherosklerose; Entzündung; Immunität; Therapie; atherosclerosis; athérosclérose; immunity; immunité; inflammation; therapy; thérapie