title: Optimizing modelling in iterative image reconstruction for preclinical pinhole PET.
abstract: The recently developed versatile emission computed tomography (VECTor) technology enables high-energy SPECT and simultaneous SPECT and PET of small animals at sub-mm resolutions. VECTor uses dedicated clustered pinhole collimators mounted in a scanner with three stationary large-area NaI(Tl) gamma detectors. Here, we develop and validate dedicated image reconstruction methods that compensate for image degradation by incorporating accurate models for the transport of high-energy annihilation gamma photons. Ray tracing software was used to calculate photon transport through the collimator structures and into the gamma detector. Input to this code are several geometric parameters estimated from system calibration with a scanning (99m)Tc point source. Effects on reconstructed images of (i) modelling variable depth-of-interaction (DOI) in the detector, (ii) incorporating photon paths that go through multiple pinholes ('multiple-pinhole paths' (MPP)), and (iii) including various amounts of point spread function (PSF) tail were evaluated. Imaging (18)F in resolution and uniformity phantoms showed that including large parts of PSFs is essential to obtain good contrast-noise characteristics and that DOI modelling is highly effective in removing deformations of small structures, together leading to 0.75 mm resolution PET images of a hot-rod Derenzo phantom. Moreover, MPP modelling reduced the level of background noise. These improvements were also clearly visible in mouse images. Performance of VECTor can thus be significantly improved by accurately modelling annihilation gamma photon transport.
authors.affiliation: Section of Radiation Detection and Medical Imaging, Applied Sciences, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
authors.forename: Marlies C
authors.initials: MC
authors.lastname: Goorden
authors.forename: Jarno
authors.initials: J
authors.lastname: van Roosmalen
authors.forename: Frans
authors.initials: F
authors.lastname: van der Have
authors.forename: Freek J
authors.initials: FJ
authors.lastname: Beekman
mesh_terms: D000818:Animals; D002138:Calibration; D005720:Gamma Rays; D051379:Mice; D019047:Phantoms, Imaging; D017785:Photons; D059629:Signal-To-Noise Ratio; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods* / Q000592:standards