title: Novel targets and interaction partners of mutant p53 Gain-Of-Function.
abstract: In many human cancers p53 expression is lost or a mutant p53 protein is expressed. Over the past 15 years it has become apparent that a large number of these mutant p53 proteins have lost wild type function, but more importantly have gained functions that promote tumorigenesis and drive chemo-resistance, invasion and metastasis. Many researchers have investigated the underlying mechanisms of these Gain-Of-Functions (GOFs) and it has become apparent that many of these functions are the result of mutant p53 hijacking other transcription factors. In this review, we summarize the latest research on p53 GOF and categorize these in light of the hallmarks of cancer as presented by Hannahan and Weinberg.
authors.affiliation: MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, U.K.
authors.forename: Lydia
authors.initials: L
authors.lastname: Aschauer
authors.affiliation: MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, U.K. pm292@le.ac.uk.
authors.forename: Patricia A J
authors.initials: PA
authors.lastname: Muller
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D042002:Chromatin Assembly and Disassembly; D004734:Energy Metabolism; D042822:Genomic Instability; D006801:Humans; D009154:Mutation; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D011485:Protein Binding; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: Gain-Of-Function; hallmarks of cancer; mutant p53