title: Molecular Iodine-Catalyzed Aerobic α,β-Diamination of Cyclohexanones with 2-Aminopyrimidine and 2-Aminopyridines.
abstract: Molecular iodine is shown to be an excellent catalyst for aerobic oxidative α,β-diamination of cyclohexanones with 2-aminopyrimidine/2-aminopyridines. This α,β-C-H functionalization is remarkable for its simplicity in both substrates and conditions, involving one and a half oxygen molecules and releasing three water molecules as the only byproduct. In addition, the functionalized products including protected 2-aminoimidazoles introduced without aromatization can serve as useful building blocks for natural product synthesis and medicinal chemistry.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay , 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Thanh Binh
authors.initials: TB
authors.lastname: Nguyen
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay , 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Ermolenko
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay , 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay , 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Mourabit