title: A panel of 74 AISNPs: Improved ancestry inference within Eastern Asia.
abstract: Many ancestry informative SNP (AISNP) panels have been published. Ancestry resolution in them varies from three to eight continental clusters of populations depending on the panel used. However, none of these panels differentiates well among East Asian populations. To meet this need, we have developed a 74 AISNP panel after analyzing a much larger number of SNPs for Fst and allele frequency differences between two geographically close population groups within East Asia. The 74 AISNP panel can now distinguish at least 10 biogeographic groups of populations globally: Sub-Saharan Africa, North Africa, Europe, Southwest Asia, South Asia, North Asia, East Asia, Southeast Asia, Pacific and Americas. Compared with our previous 55-AISNP panel, Southeast Asia and North Asia are two newly assignable clusters. For individual ancestry assignment, the likelihood ratio and ancestry components were analyzed on a different set of 500 test individuals from 11 populations. All individuals from five of the test populations - Yoruba (YRI), European (CEU), Han Chinese in Henan (CHNH), Rondonian Surui (SUR) and Ticuna (TIC) - were assigned to their appropriate geographical regions unambiguously. For the other test populations, most of the individuals were assigned to their self-identified geographical regions with a certain degree of overlap with adjacent populations. These alternative ancestry components for each individual thus help give a clearer picture of the possible group origins of the individual. We have demonstrated that the new AISNP panel can achieve a deeper resolution of global ancestry.
authors.affiliation: Key Laboratory of Forensic Genetics, Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing 100038, PR China; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 USA, USA. Electronic address: licaixia@tsinghua.org.cn.
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Li
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 USA, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Pakstis
authors.affiliation: Key Laboratory of Forensic Genetics, Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing 100038, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Immunology, Biochemistry and Molecular Biology, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, PR China.
authors.forename: Yi-Liang
authors.initials: YL
authors.lastname: Wei
authors.affiliation: Key Laboratory of Forensic Genetics, Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing 100038, PR China.
authors.forename: Qi-Fan
authors.initials: QF
authors.lastname: Sun
authors.affiliation: Laboratory of Cell Imaging, Henan University of Traditional Chinese Medicine, Zhengzhou, 450002, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 USA, USA; Institute of Forensic Science, Istanbul University, Istanbul 34098, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Bulbul
authors.affiliation: Institute of Forensic Science, Public Security Department of Guangxi Zhuang Autonomous Region, Nanning 530012, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, PR China.
authors.forename: Long-Li
authors.initials: LL
authors.lastname: Kang
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 USA, USA.
authors.forename: Judith R
authors.initials: JR
authors.lastname: Kidd
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 USA, USA. Electronic address: Kenneth.Kidd@yale.edu.
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Kidd
mesh_terms: D001210:Asia, Southeastern; D044466:Asian People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D020641:Polymorphism, Single Nucleotide
keywords: AIMs; Ancestry inference; Eastern Asia; Reference populations