title: Pancreas Cancer Surgery in Octogenarians - Should We or Should We Not?
abstract: OBJECTIVE
  In this study we aimed to determine if advanced age represents a risk factor for negative perioperative and long-term outcome in patients undergoing curative surgery ductal pancreatic adenocarcinoma surgery.
  
  
  METHODS
  Two-hundred-twenty-one consecutive patients, twelve (6%) patients ≥80 years were included in the study. We assessed perioperative and long-term outcome and independent predictors for in-hospital mortality with Cox regression analysis.
  
  
  RESULTS
  Advanced age was not a predictor for in-hospital mortality (6.3% in non-octogenarian versus 8.3% in octogenarians; p=0.55) nor for morbidity (31% vs. 32%; p=0.69). An ASA score >II was the only predictor for in-hospital mortality (odds ratio (OR)=10.10, 95%CI=1.28-79.60; Hosmer-Lemeshow: p=0.86). No significant difference was observed in one- and five-year survival rates (68 and 58% vs. 16 and 14%; log-rank p=0.61).
  
  
  CONCLUSIONS
  Advanced age is not a risk factor for negative outcome in curative pancreatic cancer surgery. Therefore, this single curative option should be considered in octogenarians at risk.
authors.affiliation: Department of General Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Katharina
authors.initials: K
authors.lastname: Marsoner
authors.affiliation: Department of General Surgery, Medical University of Graz, Graz, Austria peter.kornprat@medunigraz.at.
authors.forename: Peter
authors.initials: P
authors.lastname: Kornprat
authors.affiliation: Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Gottfried
authors.initials: G
authors.lastname: Sodeck
authors.affiliation: Department of General Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Jakob
authors.initials: J
authors.lastname: Schagerl
authors.affiliation: Department of General Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Rainer
authors.initials: R
authors.lastname: Langeder
authors.affiliation: Department of General Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Dora
authors.initials: D
authors.lastname: Csengeri
authors.affiliation: Department of General Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Doris
authors.initials: D
authors.lastname: Wagner
authors.affiliation: Department of General Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Hans Joerg
authors.initials: HJ
authors.lastname: Mischinger
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Haybaeck
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000401:mortality; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality; D012044:Regression Analysis; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Pancreatic ductal adenocarcinoma; long-term outcome; octogenarians vs. non-octogenarians; pancreatic resection; perioperative risk; short-term outcome