title: Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014.
abstract: We successfully cultured 36 Plasmodium falciparum isolates from blood samples of 44 malaria patients admitted to the Hôpital Principal de Dakar (Dakar, Senegal) during August-December 2014. The prevalence of isolates with in vitro reduced susceptibility was 30.6% for monodesethylamodiaquine, 52.8% for chloroquine, 44.1% for mefloquine, 16.7% for doxycycline, 11.8% for piperaquine, 8.3% for artesunate, 5.9% for pyronaridine, 2.8% for quinine and dihydroartemisinin, and 0.0% for lumefantrine. The prevalence of isolates with reduced in vitro susceptibility to the artemisinin-based combination therapy partner monodesethylamodiaquine increased from 5.6% in 2013 to 30.6% in 2014. Because of the increased prevalence of P. falciparum parasites with impaired in vitro susceptibility to monodesethylamodiaquine, the implementation of in vitro and in vivo surveillance of all artemisinin-based combination therapy partners is warranted.
authors.forename: Bécaye
authors.initials: B
authors.lastname: Fall
authors.forename: Marylin
authors.initials: M
authors.lastname: Madamet
authors.forename: Cheikhou
authors.initials: C
authors.lastname: Camara
authors.forename: Rémy
authors.initials: R
authors.lastname: Amalvict
authors.forename: Mansour
authors.initials: M
authors.lastname: Fall
authors.forename: Aminata
authors.initials: A
authors.lastname: Nakoulima
authors.forename: Bakary
authors.initials: B
authors.lastname: Diatta
authors.forename: Yaya
authors.initials: Y
authors.lastname: Diémé
authors.forename: Boubacar
authors.initials: B
authors.lastname: Wade
authors.forename: Bruno
authors.initials: B
authors.lastname: Pradines
mesh_terms: D000655:Amodiaquine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology*; D008297:Male; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D015995:Prevalence; D012675:Senegal / Q000453:epidemiology
chemical_list: D000962:Antimalarials; D000655:Amodiaquine; C047386:desethylamodiaquine
keywords: Dakar; Plasmodium falciparum; Senegal; antimalarial drug; antimicrobial resistance; in vitro; malaria; parasites; resistance; vector-borne infections