title: Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges.
abstract: Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins have been isolated from Poecilosclerida marine sponges. In this review, we will explore the chemodiversity of tri- and pentacyclic guanidine alkaloids. NMR and MS data tools will also be provided, and an overview of the wide range of bioactivities of crambescidins and batzelladines derivatives will be given.
authors.affiliation: Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France. sfecci@unice.fr.
authors.forename: Estelle
authors.initials: E
authors.lastname: Sfecci
authors.affiliation: Biopreserv, 4 traverse Dupont, 06130 Grasse, France. tlacour@biopreserv.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lacour
authors.affiliation: Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France. amade@unice.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Amade
authors.affiliation: Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France. mehiri@unice.fr.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mehiri
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D001685:Biological Factors / Q000737:chemistry* / Q000378:metabolism*; D019791:Guanidine / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D011161:Porifera / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D001685:Biological Factors; D019791:Guanidine
keywords: Poecilosclerida; alkaloids; analytical tools; batzelladines; bioactivity; crambescidins; marine sponges