title: [Insulin therapy: as late as possible].
abstract: While in the past non insulin treatment options were limited, and a progressive beta cell loss was thought to happen over time, (early )insulin supplementation was believed to be necessary. Many data however now indicate that there is rather a beta cell dysfunction, and that a better life style management and the new medication can help to maintain a good glycemic control without insulin supplementation, and less problems with weight management and most importantly less hypoglycemia. Furthermore, studies could not provide evidence for a benefit by early insulin treatment.
authors.forename: Stephan
authors.initials: S
authors.lastname: Jacob
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D050417:Insulin-Secreting Cells / Q000502:physiology; D017410:Practice Guidelines as Topic; D013997:Time Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin