title: Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function.
abstract: It is well recognized that the immune system and metabolism are highly integrated. In this context, multilevel interactions between metabolic system and T lymphocyte signaling and fate exist. This review will discuss different potential cell metabolism pathways involved in shaping T lymphocyte function and differentiation. We will also provide a general framework for understanding how tumor microenvironmental metabolism, associated with hypoxic stress, interferes with T-cell priming and expansion. How T-cell metabolism drives T-cell-mediated immunity and how the manipulation of metabolic programing for therapeutic purposes will be also discussed.
authors.affiliation: Laboratory BVBGR, LR11ES31, ISBST, Higher Institute of Biotechnology of Sidi Thabet, University of Manouba, Tunis, Tunisia; Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Kouidhi
authors.affiliation: Laboratory «Integrative Tumor Immunology and Genetic Oncology» Equipe Labellisée LIGUE 2015, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1186, Villejuif, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, France.
authors.forename: Muhammad Zaeem
authors.initials: MZ
authors.lastname: Noman
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301 , Orléans , France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Kieda
authors.affiliation: Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University Tunis El Manar , Tunis , Tunisia.
authors.forename: Amel Benammar
authors.initials: AB
authors.lastname: Elgaaied
authors.affiliation: Laboratory «Integrative Tumor Immunology and Genetic Oncology» Equipe Labellisée LIGUE 2015, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1186, Villejuif, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, France.
authors.forename: Salem
authors.initials: S
authors.lastname: Chouaib
keywords: T lymphocytes; cancer; hypoxia; immune system; tumor cell metabolism; tumor microenvironment