title: Air pollution exposure and preeclampsia among US women with and without asthma.
abstract: Maternal asthma and air pollutants have been independently associated with preeclampsia but rarely studied together. Our objective was to comprehensively evaluate preeclampsia risk based on the interaction of maternal asthma and air pollutants. Preeclampsia and asthma diagnoses, demographic and clinical data came from electronic medical records for 210,508 singleton deliveries. Modified Community Multiscale Air Quality models estimated preconception, first and second trimester and whole pregnancy exposure to: particulate matter (PM)<2.5 and <10µm, ozone, nitrogen oxides (NOx), sulfur dioxide (SO2) and carbon monoxide (CO); PM2.5 constituents; volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs). Asthma-pollutant interaction adjusted relative risks (RR) and 95% confidence intervals (CI) for preeclampsia were calculated by interquartile range for criteria pollutants and high exposure (≥75th percentile) for PAHs and VOCs. Asthmatics had higher risk associated with first trimester NOx and SO2 and whole pregnancy elemental carbon (EC) exposure than non-asthmatics, but only EC significantly increased risk (RR=1.11, CI:1.03-1.21). Asthmatics also had a 10% increased risk associated with second trimester CO. Significant interactions were observed for nearly all VOCs and asthmatics had higher risk during all time windows for benzene, ethylbenzene, m-xylene, o-xylene, p-xylene and toluene while most PAHs did not increase risk.
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Epidemiology Branch, Rockville, MD 20852, United States. Electronic address: pauline.mendola@nih.gov.
authors.forename: Pauline
authors.initials: P
authors.lastname: Mendola
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Epidemiology Branch, Rockville, MD 20852, United States.
authors.forename: Maeve
authors.initials: M
authors.lastname: Wallace
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Biostatistics and Bioinformatics Branch, Rockville, MD 20852, United States.
authors.forename: Danping
authors.initials: D
authors.lastname: Liu
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Epidemiology Branch, Rockville, MD 20852, United States.
authors.forename: Candace
authors.initials: C
authors.lastname: Robledo
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Epidemiology Branch, Rockville, MD 20852, United States; Northern Finland Laboratory Centre NordLab, Oulu, Finland; Department of Clinical Chemistry, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, PO Box 500, 90029 OYS, Finland; Department of Chronic Disease Prevention, National Institute for Health and Welfare, PO Box 310, 90101 Oulu, Finland.
authors.forename: Tuija
authors.initials: T
authors.lastname: Mӓnnistӧ
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Epidemiology Branch, Rockville, MD 20852, United States.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Grantz
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis; D000397:Air Pollution / Q000032:analysis*; D001249:Asthma / Q000453:epidemiology*; D002248:Carbon Monoxide / Q000032:analysis; D005260:Female; D006801:Humans; D009589:Nitrogen Oxides / Q000032:analysis; D052638:Particulate Matter / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D012306:Risk; D013458:Sulfur Dioxide / Q000032:analysis; D014481:United States / Q000453:epidemiology; D055549:Volatile Organic Compounds / Q000032:analysis; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D009589:Nitrogen Oxides; D052638:Particulate Matter; D011084:Polycyclic Aromatic Hydrocarbons; D055549:Volatile Organic Compounds; D013458:Sulfur Dioxide; D002248:Carbon Monoxide
keywords: Air pollution; Asthma; Hypertension; Preeclampsia; Pregnancy