title: Memory deficit in Swiss mice exposed to tannery effluent.
abstract: Although it is known that tannery effluents constitute highly toxic pollutants whose effects in humans represent public health problems in several countries, studies involving experimental mammalian models are rare. In this context, the objective of the present study was to assess the effect of the exposure to tannery effluent on the memory of male and female Swiss mice. Animals of each sex were distributed into two experimental groups: the control group, in which the animals received only drinking water and the effluent group, in which the mice received 1% of gross tannery effluent diluted in water. The animals were exposed to the effluent by gavage, oral dosing, for 15days, ensuring the administration of 0.1mL of liquid (water or effluent)/10g of body weight/day. On the 14th and 15th experimental days the animals were submitted to the object recognition test. It was observed that the new object recognition indices calculated for the animals exposed to the effluent (males and females) were significantly lower than those obtained with the control group. The exposure to tannery effluent caused memory deficit in Swiss mice in a similar way for both sexes, reinforcing previous findings that these pollutants affect the central nervous system. It contributes to the knowledge in the area by attesting harmful effects to the cognition of such animals.
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Letícia Martins
authors.initials: LM
authors.lastname: Rabelo
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Bianca
authors.initials: B
authors.lastname: Costa E Silva
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Sabrina Ferreira
authors.initials: SF
authors.lastname: de Almeida
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Wellington Alves Mizael
authors.initials: WA
authors.lastname: da Silva
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: de Oliveira Mendes
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Abraão Tiago Batista
authors.initials: AT
authors.lastname: Guimarães
authors.affiliation: Laboratório de Estatística Experimental, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Anderson Rodrigo
authors.initials: AR
authors.lastname: da Silva
authors.affiliation: Laboratório de Zoologia, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Programa de Pós-graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: André Luis
authors.initials: AL
authors.lastname: da Silva Castro
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Programa de Pós-graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Aline Sueli
authors.initials: AS
authors.lastname: de Lima Rodrigues
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Programa de Pós-graduação em Biodiversidade Animal, Universidade Federal de Goiás - Campus Samambaia, GO, Brazil; Programa de Pós-graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Electronic address: guilhermeifgoiano@gmail.com.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Malafaia
mesh_terms: D000818:Animals; D005260:Female; D007220:Industrial Waste / Q000009:adverse effects*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D051379:Mice; D021641:Recognition, Psychology / Q000187:drug effects; D013633:Tanning; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D007220:Industrial Waste; D014874:Water Pollutants, Chemical
keywords: Cognition; Experimental models; Tannery effluent; Xenobiotic