title: Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells.
abstract: Impact of redox active transition metals on activation of cell death signaling in plant cells have been documented to date. We have recently reported that GC-rich DNA oligomers with high affinity for binding of copper and catalytic activity for removal of ROS as novel plant cell-protecting agents. Here, we show that similar DNA oligomers protect the mouse macrophage-like RAW264.7 cells from copper-induced cell death, suggesting that the phenomenon firstly observed in plant model can be expanded to a wider range of cells and/or organisms including mammalian cells.
authors.affiliation: Faculty and Graduate School of Environmental Engineering; The University of Kitakyushu ; Kitakyushu, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Matsushita
authors.affiliation: Faculty and Graduate School of Environmental Engineering; The University of Kitakyushu ; Kitakyushu, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Mochizuki
authors.affiliation: Faculty and Graduate School of Environmental Engineering; The University of Kitakyushu ; Kitakyushu, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakurai
authors.affiliation: Faculty and Graduate School of Environmental Engineering; The University of Kitakyushu ; Kitakyushu, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kawano
keywords: DNA oligomers; ROS; cell death; mammalian cells; metal toxicity; plant cells