title: Predictors of Organ Damage Progression and Effect on Health-related Quality of Life in Systemic Lupus Erythematosus.
abstract: To describe organ damage accrual, predictors of damage progression, and effect on health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE).
  
  
  
  A longitudinal database of patients who met the American College of Rheumatology (ACR) classification criteria for SLE was used. Annual assessments included the Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) and the Medical Outcomes Study Short Form-36 (SF-36). The prognostic significance of demographic, disease-related, and treatment-related factors on damage progression was examined using multivariable Cox regression. The effect of changes in SDI scores on HRQOL, measured using the SF-36 summary and subscale scores, was assessed using linear mixed-effects modeling.
  
  
  
  There were 273 patients with SLE studied over a mean (SD) duration of followup of 7.3 (4.3) years. During followup, 126 (46.2%) had an increase in SDI scores. Patients with preexisting damage at baseline were more likely to have earlier damage progression (HR 2.09, 95% CI 1.44-3.01). Older age, ≥ 8 ACR classification criteria, immunosuppressive drugs, cigarette smoking, and higher mean serum C-reactive protein levels were associated with an earlier increase in SDI scores in multivariable analysis. In general, changes in SDI scores were associated with initial declines in SF-36 scores at the time that damage occurred, with subsequent change comparable to that seen in patients without damage progression.
  
  
  
  This study identified multiple risk factors, some modifiable, associated with damage progression in patients with SLE. The negative effect on HRQOL emphasizes the need for treatment strategies to reduce the risk of organ damage over time.
authors.affiliation: From the Division of Rheumatology, Department of Medicine, and Department of Pathology, Nova Scotia Health Authority, Dalhousie University; Research Methods Unit, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.A. Legge, MD, Department of Medicine, Nova Scotia Health Authority, Dalhousie University; S. Doucette, MSc, Research Methods Unit, Nova Scotia Health Authority; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Department of Medicine, and Department of Pathology, Nova Scotia Health Authority, Dalhousie University.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Legge
authors.affiliation: From the Division of Rheumatology, Department of Medicine, and Department of Pathology, Nova Scotia Health Authority, Dalhousie University; Research Methods Unit, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.A. Legge, MD, Department of Medicine, Nova Scotia Health Authority, Dalhousie University; S. Doucette, MSc, Research Methods Unit, Nova Scotia Health Authority; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Department of Medicine, and Department of Pathology, Nova Scotia Health Authority, Dalhousie University.
authors.forename: Steve
authors.initials: S
authors.lastname: Doucette
authors.affiliation: From the Division of Rheumatology, Department of Medicine, and Department of Pathology, Nova Scotia Health Authority, Dalhousie University; Research Methods Unit, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.A. Legge, MD, Department of Medicine, Nova Scotia Health Authority, Dalhousie University; S. Doucette, MSc, Research Methods Unit, Nova Scotia Health Authority; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Department of Medicine, and Department of Pathology, Nova Scotia Health Authority, Dalhousie University. john.hanly@cdha.nshealth.ca.
authors.forename: John G
authors.initials: JG
authors.lastname: Hanly
mesh_terms: D000328:Adult; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: DAMAGE; HEALTH-RELATED QUALITY OF LIFE; SYSTEMIC LUPUS ERYTHEMATOSUS