title: Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus.
abstract: Meniscal lesions are common problems in orthopaedic surgery and sports medicine, and injury or loss of the meniscus accelerates the onset of knee osteoarthritis (OA). Despite a variety of therapeutic options in the clinics, there is a critical need for improved treatments to enhance meniscal repair. In this regard, combining gene-, cell-, and tissue engineering-based approaches is an attractive strategy to generate novel, effective therapies to treat meniscal lesions. In the present work, we provide an overview of the tools currently available to improve meniscal repair and discuss the progress and remaining challenges for potential future translation in patients.
authors.affiliation: Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Saar, Germany. Electronic address: mmcucchiarini@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Cucchiarini
authors.affiliation: Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: McNulty
authors.affiliation: McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Mauck
authors.affiliation: Center of Regenerative Medicine, Departments of Orthopaedic Surgery, Developmental Biology, and Biomedical Engineering, Shriners Hospitals for Children, Washington University, St. Louis, MO, USA; Shriners Hospitals for Children, St. Louis, MO, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Setton
authors.affiliation: Center of Regenerative Medicine, Departments of Orthopaedic Surgery, Developmental Biology, and Biomedical Engineering, Shriners Hospitals for Children, Washington University, St. Louis, MO, USA; Shriners Hospitals for Children, St. Louis, MO, USA.
authors.forename: F
authors.initials: F
authors.lastname: Guilak
authors.affiliation: Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Saar, Germany; Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Saar, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Madry
mesh_terms: D015316:Genetic Therapy; D006801:Humans; D008592:Menisci, Tibial; D000072600:Meniscus; D000070600:Tibial Meniscus Injuries; D023822:Tissue Engineering; D014945:Wound Healing
keywords: Cell therapy; Gene therapy; Meniscal repair; Meniscus; Tissue engineering