title: Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy.
abstract: Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.
authors.affiliation: Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
authors.forename: Qianyun
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Wu
authors.affiliation: Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
authors.forename: Weili
authors.initials: W
authors.lastname: Si
authors.affiliation: Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Dong
mesh_terms: D006820:Hyaluronic Acid; D009369:Neoplasms; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D011758:Pyrroles; D006820:Hyaluronic Acid
keywords: bromo-substituted; diketopyrrolopyrrole; hyaluronic acid; photodynamic therapy; photosensitizers