title: An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.
abstract: Metastasis remains the primary cause of patient morbidity and mortality in solid tumors and is due to the action of a large number of tumor-autonomous and non-autonomous factors. Here we report the results of a genome-wide integrated strategy to identify novel metastasis susceptibility candidate genes and molecular pathways in breast cancer metastasis. This analysis implicates a number of transcriptional regulators and suggests cell-mediated immunity is an important determinant. Moreover, the analysis identified novel or FDA-approved drugs as potentially useful for anti-metastatic therapy. Further explorations implementing this strategy may therefore provide a variety of information for clinical applications in the control and treatment of advanced neoplastic disease.
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Ling
authors.initials: L
authors.lastname: Bai
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Howard H
authors.initials: HH
authors.lastname: Yang
authors.affiliation: Center for Bioinformatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Anjali
authors.initials: A
authors.lastname: Shukla
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Ngoc-Han
authors.initials: NH
authors.lastname: Ha
authors.affiliation: Computational Genomics Program, Welcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: Doran
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Farhoud
authors.initials: F
authors.lastname: Faraji
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Natalie
authors.initials: N
authors.lastname: Goldberger
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Maxwell P
authors.initials: MP
authors.lastname: Lee
authors.affiliation: Computational Genomics Program, Welcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom.
authors.forename: Thomas
authors.initials: T
authors.lastname: Keane
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Kent W
authors.initials: KW
authors.lastname: Hunter
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics; D045744:Cell Line, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D051741:Kruppel-Like Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D008175:Lung Neoplasms / Q000556:secondary*; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008814:Mice, Inbred NZB; D008822:Mice, Transgenic; D000075983:Nectins; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology
chemical_list: D015815:Cell Adhesion Molecules; D051741:Kruppel-Like Transcription Factors; D000075983:Nectins; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D034741:RNA, Small Interfering; D045162:Thiazolidinediones; C513267:Zbtb16 protein, mouse; D000077154:Rosiglitazone