title: Complete reversal of hypertensive cardiomyopathy after initiating combined antihypertensive therapy.
abstract: Hypertensive cardiomyopathy is a common complication of hypertension, with a prevalence ranging from 12% to 26%. It is associated with an increased cardiac mortality and morbidity. Lifestyle changes and antihypertensive therapy usually have a significant, but relatively small effect on left ventricular hypertrophy (LVH), which is associated with a reduction in cardiovascular risk. In this paper, we describe a 39-year-old woman with severe LVH. On transthoracic echocardiogram there was concentric LVH, systolic function was a mildly reduced and there was diastolic dysfunction grade III. After only 6 months of therapy with a combination of antihypertensive agents, the left ventricular mass index was reduced by 29%, systolic function was normal and the diastolic dysfunction improved to grade I. This paper shows that in hypertensive cardiomyopathy, even severe LVH can be completely reversible.
authors.affiliation: Department of Cardiology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Marijn J
authors.initials: MJ
authors.lastname: Holl
authors.affiliation: Department of Cardiology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Sweder W
authors.identifier: http://orcid.org/0000-0002-1329-8673
authors.initials: SW
authors.lastname: van de Poll
authors.affiliation: Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Michelle
authors.initials: M
authors.lastname: Michels
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D004359:Drug Therapy, Combination; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents