title: Sleep Disorders in Multiple Sclerosis.
abstract: Recent studies suggest that individuals with multiple sclerosis (MS) are at increased risk for sleep disturbances and that sleep disturbances contribute to fatigue and other chronic symptoms in MS. Although fatigue occurs commonly in people with MS, this symptom is often attributed to MS-specific pathology. Consequently, sleep disorders are often unrecognized and untreated in this population. Timely diagnosis and treatment of sleep problems in MS offer a new opportunity to ameliorate some of the daytime fatigue experienced by patients with MS. To increase this opportunity, the practitioner should be comfortable performing basic screening for common sleep complaints among patients with MS. The objectives of this review are to summarize the latest relevant data on sleep disorders in MS and offer a helpful approach to the identification and workup of the most common sleep problems in this population. Unexplored research avenues and opportunities to address important questions at the interface of sleep and MS are also discussed.
authors.affiliation: University of Michigan Department of Neurology, Multiple Sclerosis and Sleep Disorders Centers, 1500 E. Medical Center Dr, C728 Med-Inn Building, Ann Arbor, MI, USA.
authors.forename: Tiffany J
authors.initials: TJ
authors.lastname: Braley
authors.affiliation: Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road L226, Portland, OR, 97239-3098, USA. boudreau@ohsu.edu.|Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road L226, Portland, OR, 97239-3098, USA. boudreau@ohsu.edu.|Portland VA Medical Center, P3-ECOE, 3710 SW US Veterans Hospital Road, Portland, OR, 97239, USA. boudreau@ohsu.edu.
authors.forename: Eilis Ann
authors.initials: EA
authors.lastname: Boudreau
mesh_terms: D005221:Fatigue / Q000209:etiology; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications*; D012148:Restless Legs Syndrome / Q000145:classification; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000209:etiology*
keywords: Fatigue; Insomnia; Multiple sclerosis; Obstructive sleep apnea; Restless leg syndrome