title: The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents.
abstract: The hypothalamus plays a fundamental role in regulating homeostatic processes including regulation of food intake. Food intake is driven in part by energy balance, which is sensed by specific brain structures through signaling molecules such as nutrients and hormones. Both circulating glucose and fatty acids decrease food intake via a central mechanism involving the hypothalamus and brain stem. Besides playing a role in signaling energy status, glucose and fatty acids serve as fuel for neurons. This review focuses on the effects of glucose and fatty acids on hypothalamic pathways involved in regulation of energy metabolism as well as on the role of the family of peroxisome proliferator activated receptors (PPARs) which are implicated in regulation of central energy homeostasis. We further discuss the effects of different hypercaloric diets on these pathways.
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Merel
authors.initials: M
authors.lastname: Rijnsburger
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Evita
authors.initials: E
authors.lastname: Belegri
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Leslie
authors.initials: L
authors.lastname: Eggels
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Unga A
authors.initials: UA
authors.lastname: Unmehopa
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Anita
authors.initials: A
authors.lastname: Boelen
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Mireille J
authors.initials: MJ
authors.lastname: Serlie
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: s.e.lafleur@amc.uva.nl.
authors.forename: Susanne E
authors.initials: SE
authors.lastname: la Fleur
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000378:metabolism; D004032:Diet / Q000379:methods*; D004435:Eating; D004734:Energy Metabolism / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006706:Homeostasis; D007031:Hypothalamus / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000378:metabolism; D012377:Rodentia; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors
keywords: Energy; Fatty acids; Glucose; Hypercaloric diet; Hypothalamus; Metabolism; Nutrient sensing