title: Diazepam sorption to PVC- and non-PVC-based tubes in administration sets with quantitative determination using a high-performance liquid chromatographic method.
abstract: Diazepam is highly sorbed to the plastic materials of administration sets for intravenous infusion. This can be detrimental as it should be delivered to the patient at the administered amount for efficacy and safety. We report here the sorption levels of diazepam onto various types of tubes in administration sets. The tube materials of the administration sets included polyvinylchloride (PVC) and the non-PVC materials such as polyurethane (PU) and polyolefin (PO) were used. Two conditions of diazepam administered in preclinical and clinical settings were tested using an infusion pump. Injections were prepared by diluting diazepam to 20mg/500mL and 10mg/100mL in 5% dextrose. Diluted diazepam solutions at the concentrations of 10mg/100mL and 20mg/500mL were separately delivered through 1m of tubing at 1mL/min for 1.05 and 4.05h. Samples were analyzed using a high-performance liquid chromatography with UV detection. PVC- and PU-based tubes showed higher sorption of diazepam than did PO-based tubes. PO-based tubes delivered more than 90% of the administered diazepam. The results showed that PO-based tubes of administration sets have a promising potential to deliver hydrophobic drugs like diazepam with minimal sorption levels. In addition, the tube materials in administration sets may be one of the critical factors to ensure drug efficacy and safety.
authors.affiliation: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea; College of Medicine, Yonsei University, Seoul 03722, Republic of Korea; Yonsei Institute of Pharmaceutical Sciences, Incheon 21983, Republic of Korea.
authors.forename: Su-Eon
authors.initials: SE
authors.lastname: Jin
authors.affiliation: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea; Yonsei Institute of Pharmaceutical Sciences, Incheon 21983, Republic of Korea.
authors.forename: Siwon
authors.initials: S
authors.lastname: You
authors.affiliation: Polyscientech Co., Ltd., Anseong, Gyeonggi 17508, Republic of Korea.
authors.forename: Seungho
authors.initials: S
authors.lastname: Jeon
authors.affiliation: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea; Yonsei Institute of Pharmaceutical Sciences, Incheon 21983, Republic of Korea. Electronic address: sjh11@yonsei.ac.kr.
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Hwang
mesh_terms: D000327:Adsorption; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003975:Diazepam / Q000737:chemistry*; D006993:Hypnotics and Sedatives / Q000737:chemistry*; D007262:Infusions, Intravenous / Q000295:instrumentation; D011090:Polyenes / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry
chemical_list: D006993:Hypnotics and Sedatives; D011090:Polyenes; D011140:Polyurethanes; C035051:PL 732; D011143:Polyvinyl Chloride; D003975:Diazepam
keywords: Administration set; Diazepam; Non-PVC; PVC; Sorption; Tube