title: Stroke Damage Is Exacerbated by Nano-Size Particulate Matter in a Mouse Model.
abstract: This study examines the effects of nano-size particulate matter (nPM) exposure in the setting of murine reperfused stroke. Particulate matter is a potent source of inflammation and oxidative stress. These processes are known to influence stroke progression through recruitment of marginally viable penumbral tissue into the ischemic core. nPM was collected in an urban area in central Los Angeles, impacted primarily by traffic emissions. Re-aerosolized nPM or filtered air was then administered to mice through whole body exposure chambers for forty-five cumulative hours. Exposed mice then underwent middle cerebral artery occlusion/ reperfusion. Following cerebral ischemia/ reperfusion, mice exposed to nPM exhibited significantly larger infarct volumes and less favorable neurological deficit scores when compared to mice exposed to filtered air. Mice exposed to nPM also demonstrated increases in markers of inflammation and oxidative stress in the region of the ischemic core. The findings suggest a detrimental effect of urban airborne particulate matter exposure in the setting of acute ischemic stroke.
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Robin
authors.initials: R
authors.lastname: Babadjouni
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Ryan
authors.initials: R
authors.lastname: Radwanski
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Hank
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Arati
authors.initials: A
authors.lastname: Patel
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Drew M
authors.initials: DM
authors.lastname: Hodis
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Shuhan
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Peter
authors.initials: P
authors.lastname: Baumbacher
authors.affiliation: Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Russin
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Morgan
authors.affiliation: Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Sioutas
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America.|Department of Neurobiology, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Caleb E
authors.initials: CE
authors.lastname: Finch
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.|Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
authors.forename: William J
authors.initials: WJ
authors.lastname: Mack
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology; D007249:Inflammation / Q000139:chemically induced; D015141:Los Angeles; D051379:Mice; D053758:Nanoparticles / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects*; D015424:Reperfusion / Q000379:methods; D020521:Stroke / Q000503:physiopathology*
chemical_list: D052638:Particulate Matter