title: Blood triacylglycerols: a lipidomic window on diet and disease.
abstract: Although the measurement of triacylglycerols (TAGs) by clinical chemistry has been used in the diagnosis of a range of metabolic diseases, such approaches ignore the different species of TAGs that contribute to the total concentration. With the advent of LC and direct infusion forms of MS it is now possible to profile the individual TAGs in blood plasma or tissue extracts. This mini review surveys the information that is obtainable from the lipidomic profiling of TAGs in following metabolic diseases such as type 2 diabetes (T2DM), cardiovascular disease (CVD) and non-alcoholic fatty liver disease, as well as the development of insulin resistance and obesity.
authors.affiliation: Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, U.K. Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, U.K.
authors.forename: Francis
authors.initials: F
authors.lastname: Sanders
authors.affiliation: Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, U.K. Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, U.K.
authors.forename: Ben
authors.initials: B
authors.lastname: McNally
authors.affiliation: Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, U.K. Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, U.K. jules.griffin@mrc-hnr.cam.ac.uk jlg40@cam.ac.uk.
authors.forename: Julian L
authors.initials: JL
authors.lastname: Griffin
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004032:Diet; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood*; D009765:Obesity / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D014280:Triglycerides
keywords: insulin resistance; liquid chromatography mass spectrometry; metabolomics; non-alcoholic fatty liver disease; obesity; type 2 diabetes