title: Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review.
abstract: Differentiating low-grade lymphoma from preexisting sarcoidosis is difficult because of their pathological similarity. This article describes a case of pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis. The patient, a 45-year-old Japanese man, presented with a 10-year history of pulmonary sarcoidosis and 5-year history of ocular sarcoidosis with histologic findings. Because only the right S3 lung nodule had gradually enlarged, partial resection was performed. Pathological study revealed noncaseous epithelioid granulomas with lymphoplasmacytic proliferation but also marked lymphoid cell proliferation with lymphoepithelial lesion findings that differed from findings of typical sarcoid lesions. Our lymphoepithelial lesion evaluation via immunohistochemistry and analysis of Ig heavy-chain gene rearrangements with assessment of Propionibacterium acnes-specific antibody reactions allow us to report, for the first time, this case of pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis in exactly the same location, which may be significant for differentiating these diseases and understanding their pathogenic association.
authors.affiliation: Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Nariaki
authors.initials: N
authors.lastname: Kokuho
authors.affiliation: Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan. Electronic address: terasaki@nms.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Terasaki
authors.affiliation: Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Urushiyama
authors.affiliation: Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Terasaki
authors.affiliation: Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kunugi
authors.affiliation: Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Morimoto
authors.affiliation: Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Arata
authors.initials: A
authors.lastname: Azuma
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Usuda
authors.affiliation: Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Gemma
authors.affiliation: Department of Human Pathology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Eishi
authors.affiliation: Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017565:Sarcoidosis, Pulmonary / Q000150:complications*
keywords: Lymphoma; MALT; Propionibacterium acnes–specific monoclonal antibody; Pulmonary mucosa-associated lymphoid tissue lymphoma; Sarcoidosis