title: Effects of inhibiting connexin43 on expression of fibroblast growth factor in prolactinomas in rats.
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of connexin43(Cx43) on basic fibroblast growth factor (bFGF) expression by inhibiting Cx43 expression in prolactinomas in rats.
  
  
  METHODS
  An experimental rat model of prolactinoma induced by estradiol (E2) treatment was used. Gap junction inhibitor was applied in through the arachnoid space by injection of carbenoxolone (CBX). Cx43 and bFGF expression was examined by both western blotting, respectively.
  
  
  RESULTS
  Pituitaries treated with E2 were hypertrophic, but this was reduced by CBX treatment. Estradiol induced Cx43 and bFGF expression, which decreased following CBX treatment.
  
  
  CONCLUSIONS
  Altered Cx43 expression modulates bFGF expression, which correlates with prolactinoma development.
authors.affiliation: a Department of Neurosurgery , The Affiliated Hospital of Jining Medical University , Jining , China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Department of Neurosurgery , The Affiliated Hospital of Jining Medical University , Jining , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.affiliation: b Department of Rehabilitation Medicine , The Affiliated Hospital of Jining Medical University , Jining , China.
authors.forename: Yaju
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Department of Neurosurgery , The Affiliated Hospital of Jining Medical University , Jining , China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002229:Carbenoxolone / Q000627:therapeutic use; D018031:Connexin 43 / Q000378:metabolism*; D004195:Disease Models, Animal; D004958:Estradiol / Q000633:toxicity; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000473:pathology; D010911:Pituitary Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D015175:Prolactinoma / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats
chemical_list: D018031:Connexin 43; D004958:Estradiol; D005346:Fibroblast Growth Factors; D002229:Carbenoxolone
keywords: Connexin43; Fibroblast growth factor; Gap junction inhibitor; Prolactinoma