title: Regulation of food intake and the development of anti-obesity drugs.
abstract: As the most significant cause of death worldwide, obesity has become one of the world's most important public health problems, but approved anti-obesity drugs are extremely limited. This article summarizes the feeding control circuits and regulators involved in obesity development, highlight the hypothalamus, melanocortin system and brain-gut peptide actions in this process, and the five US FDA approved anti-obesity medications in long term use, namely phentermine/topiramate, lorcaserin, naltrexone/bupropion, liraglutide and orlistat.
authors.affiliation: Pharmacy Department, PLA General Hospital.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
mesh_terms: D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000494:pharmacology / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects*; D006801:Humans
chemical_list: D019440:Anti-Obesity Agents; D001067:Appetite Depressants