title: Are Diuretics Underutilized in Dialysis Patients?
abstract: While oral diuretics are commonly used in patients with chronic kidney disease for the management of volume and blood pressure, they are often discontinued upon initiation of dialysis. We suggest that diuretics are considerably underutilized in peritoneal dialysis and haemodialysis patients despite numerous potential benefits and few side effects. Moreover, when diuretics are used, optimal doses are not always prescribed. In peritoneal dialysis, the use of diuretics can improve volume status and minimize the need for higher glucose-containing solutions. In patients on haemodialysis, diuretics can help lessen interdialytic weight gain, resulting in decreased ultrafiltration rates and fewer episodes of intradialytic hypotension. This paper will review the mechanism of action of diuretics in patients with renal insufficiency, quantify the risk of side effects and elaborate on the potential advantages of diuretic use in peritoneal dialysis and hemodialysis patients with residual kidney function.
authors.affiliation: Division of Nephrology, University Health Network, Toronto, Ontario, Canada.
authors.forename: Emilie
authors.initials: E
authors.lastname: Trinh
authors.affiliation: Division of Nephrology, University Health Network, Toronto, Ontario, Canada. joanne.bargman@uhn.ca.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Bargman
mesh_terms: D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D007022:Hypotension; D007676:Kidney Failure, Chronic / Q000628:therapy*; D010530:Peritoneal Dialysis; D006435:Renal Dialysis
chemical_list: D004232:Diuretics