title: [Characteristic of spatial-temporal distribution of hepatitis E in Hunan province, 2006-2014].
abstract: OBJECTIVE
  To analyze the spatial-temporal distribution of Hepatitis E (HEV) in Hunan province from 2006 to 2014.
  
  
  METHODS
  Data related to HEV cases in Hunan province from 2006 to 2014 were collected from the Infectious Diseases Reporting Information System in the formation System of Disease Prevention and Control of China. Based on ArcGIS (10.2) and SaTScan(version 9.1), spatial autocorrelation analysis and space-time clustering analysis were used to study the prevalence on HEV.
  
  
  RESULTS
  A total of 7 124 HEV cases were reported with 3 deaths during this period. The average annual incidence rate was 1.22/10(5). Most of the cases were over 55 years old and the majority of them (54.15%) were farmers. The distribution of HEV showed differences on locations and the regions with high incidence seen in northern and western areas of Hunan. However the regions with low incidence appeared in central or southern parts of Hunan. Data from the global spatial autocorrelation analysis showed that there was space autocorrelation on the HEV incidence rates in counties (cities, districts) (Moran'I was positive,P<0.05). A total of 31 countries were found in the high-high region with most of the clusters located in northern and western Hunan. According to local indication of spatial autocorrelation analysis, 31 countries in high-high region all showed statistically significant differences (P<0.05). RESULTS from the space-time scan showed 7 space-time clustering areas, including those most likely in the western Hunan area (2012-2014); the secondary clusters in northern Hunan areas (2011-2014).
  
  
  CONCLUSIONS
  Significant cluster pattern was found in the distribution of HEV in Hunan province. Clusters found in northern and western of Hunan province were seen more than in other regions.
authors.affiliation: Department of Preventive Medicine, Medicine School of Hunan Normal University, Changsha 410013, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Preventive Medicine, Medicine School of Hunan Normal University, Changsha 410013, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Liang
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China, Central Office.
authors.forename: Junhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China, Emergency Office.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Preventive Medicine, Medicine School of Hunan Normal University, Changsha 410013, China.
authors.forename: Guifeng
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Preventive Medicine, Medicine School of Hunan Normal University, Changsha 410013, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Zha
authors.affiliation: Department of Preventive Medicine, Medicine School of Hunan Normal University, Changsha 410013, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Preventive Medicine, Medicine School of Hunan Normal University, Changsha 410013, China.
authors.forename: Guochao
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D002947:Cities; D016000:Cluster Analysis; D000067565:Farmers / Q000706:statistics & numerical data; D016751:Hepatitis E / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies; D013029:Space-Time Clustering; D062206:Spatial Analysis