title: Recombination and phenotype evolution dynamics of Helicobacter pylori in colonized hosts.
abstract: The ample genetic diversity and variability of Helicobater pylori, and therefore its phenotypic evolution, relate not only to frequent mutation and selection but also to intra-specific recombination. Webb and Blaser applied a mathematical model to distinguish the role of selection and mutation for Lewis antigen phenotype evolution during long-term gastric colonization in infected animal hosts (mice and gerbils). To investigate the role of recombination in Lewis antigen phenotype evolution, we have developed a prior population dynamic by adding recombination term to the model. We simulate and interpret the new model simulation's results with a comparative analysis of biological aspects. The main conclusions are as follows: (i) the models and consequently the hosts with higher recombination rate require a longer time for stabilization; and (ii) recombination and mutation have opposite effects on the size of H. pylori populations with phenotypes in the range of the most-fit ones (i.e. those that have a selective advantage) due to natural selection, although both can increase phenotypic diversity.
authors.affiliation: Department of Mathematics, Faculty of Mathematical Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shafiee
authors.affiliation: Department of Mathematics, Faculty of Mathematical Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Amini
authors.affiliation: School of Mathematics, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.|Laboratoire de Mathématiques, Université de Poitiers, téléport 2, Chassneuil du Poitou, Cedex, France.
authors.forename: Hassan
authors.initials: H
authors.lastname: Emamirad
authors.affiliation: Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: Amin Talebi Bezmin
authors.initials: ATB
authors.lastname: Abadi
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D005260:Female; D014644:Genetic Variation; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological; D010641:Phenotype; D011995:Recombination, Genetic; D013270:Stomach / Q000382:microbiology
keywords: Helicobacter pylori; Lewis antigen; evolution; mutation; recombination; selection; stabilization