title: The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases.
abstract: Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. Here, we provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes.
authors.affiliation: Department of Dermatology, University Medical Center Mainz, Johannes Gutenberg-University Mainz , Mainz , Germany.
authors.forename: Verena Katharina
authors.initials: VK
authors.lastname: Raker
authors.affiliation: Department of Dermatology, University Medical Center Mainz, Johannes Gutenberg-University Mainz , Mainz , Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Becker
authors.affiliation: Department of Dermatology, University Medical Center Mainz, Johannes Gutenberg-University Mainz , Mainz , Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Steinbrink
keywords: T cells; T regulatory cells; Tregs; autoimmunity; cyclic AMP; inflammation; targeted therapies