title: A Theranostic Two-Tone Luminescent PhotoCORM Derived from Re(I) and (2-Pyridyl)-benzothiazole: Trackable CO Delivery to Malignant Cells.
abstract: A Re(I) carbonyl complex derived from 2-(2-pyridyl)-benzothiazole (pbt), [Re(H2O)(CO)3(pbt)](CF3SO3) (1), rapidly releases CO under low-power UV illumination. CO photorelease from 1 is accompanied by a change in luminescence from orange to deep blue. These two distinct luminescence signals have been successfully employed to track (a) the entry of the pro-drug 1 into cancer cells and (b) the end of the CO (drug) delivery step within the target.
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Carrington
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
authors.forename: Indranil
authors.initials: I
authors.lastname: Chakraborty
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720, United States.
authors.forename: Jenna M L
authors.initials: JM
authors.lastname: Bernard
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Mascharak
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry; D001943:Breast Neoplasms / Q000628:therapy; D002248:Carbon Monoxide / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006801:Humans; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D009211:Myoglobin / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry*; D011355:Prodrugs / Q000008:administration & dosage; D011725:Pyridines / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D052160:Benzothiazoles; D004337:Drug Carriers; D009211:Myoglobin; D009942:Organometallic Compounds; D011355:Prodrugs; D011725:Pyridines; D012211:Rhenium; D002248:Carbon Monoxide