title: [Progress in epigenetic research on Alzheimer disease].
abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder, which features mainly with memory impairment as the initial symptom of progressive loss of cognitive function. Its main pathological changes include senile plaques and neurofibrillary tangles. The pathogenesis of AD is still unclear, though it may be connected with aging, genetic factors and environmental factors. Among these, aging and environmental factors can be modified by epigenetics. In this paper, advances in the study of epigenetic mechanisms related to the pathogenesis of AD are reviewed.
authors.affiliation: Department of Neurology, Xiangya Hospital Affiliated to Central South University Xiangya Medical School, Changsha, Hunan 410008, China. bstang7398@163.com.
authors.forename: Nannan
authors.initials: N
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Wei
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology; D000818:Animals; D003071:Cognition; D044127:Epigenesis, Genetic; D006801:Humans