title: CYP1A1MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis.
abstract: Numerous case-control studies have investigated whether theCYP1A1gene polymorphism is involved in the occurrence of oral squamous cell carcinoma (OSCC); however, the conclusions are inconsistent. In order to further explore the correlation and obtain a strong conclusion, a meta-analysis was performed to systematically assess the association between theCYP1A1MspI polymorphism and risk of OSCC. In the present meta-analysis, the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical analyses were performed with STATA 11.0 software. The heterogeneity was assessed by Q test and I2test. The final analysis included 10 studies of 1,505 cases and 1,967 controls. The overall results suggested that theCYP1A1MspI polymorphism was significantly associated with an increased risk of OSCC (CC+TC vs. TT: OR, 1.31; 95% CI, 1.01-1.70; P=0.043; CC vs. TC+TT: OR, 2.38; 95% CI, 1.58-3.58; P<0.001; CC vs. TT: OR, 2.52; 95% CI, 1.60-3.96; P<0.001; and C vs. T: OR, 1.45; 95% CI, 1.15-1.83; P<0.001). In a stratified analysis by ethnicity, a statistically significant correlation existed in the Asian population, but not mixed-race and Caucasian populations. In conclusion, despite several limitations, the present meta-analysis established that theCYP1A1MspI polymorphism may be a risk factor for OSCC, particularly among the Asian population.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
authors.forename: Shang
authors.initials: S
authors.lastname: Xie
authors.affiliation: Guanghua School and Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, P.R. China.
authors.forename: Chongdai
authors.initials: C
authors.lastname: Luo
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Shan
authors.affiliation: Department of Orthopaedic Surgery, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Shushan
authors.initials: S
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Cai
keywords: CYP1A1; meta-analysis; oral squamous cell carcinoma; polymorphism