title: Chronic myeloid leukaemia in Spain: Its presentation characteristics have changed. Spanish section of the EUTOS population-based registry.
abstract: OBJECTIVE
  To provide more reliable data on the epidemiology of chronic myeloid leukaemia (CML) in Spain than are currently available.
  
  
  METHODS
  The EUTOS population-based project of European LeukemiaNet is a population registry of new CML cases in patients 18 years of age or older from 22 European areas. The Spanish section included the autonomous communities of Madrid, Castilla-La Mancha and Aragon, from 1-2-2010 to 31-12-2012.
  
  
  RESULTS
  A total of 250 cases were recorded in 35 months. The overall incidence was 1.08 cases/10(5) inhabitants-year, with a predominance of men (58%) and clear differences among the communities. The incidence standardised by age was similar (overall, 1.04; men, 1.31; women, 0.81). The median age was 54 years. The incidence increased with age, reaching a peak at>65 years, although 31.7% of cases appeared between the ages of 20 and 44 years. Four percent of cases were diagnosed in advanced stages (2.4% in accelerated phase, 1.6% in blast crisis), 56% were asymptomatic, 38% had splenomegaly, and the Sokal score was high in 11% (lower than what was previously reflected in the literature).
  
  
  CONCLUSIONS
  The current incidence of CML in Spain is higher than previously reported and similar to that of the European studies. Unlike the classical descriptions, CML presented mostly in asymptomatic form, with no splenomegaly, less leucocytosis and in stages with better prognosis.
authors.affiliation: Servicio de Hematología, Hospital Gregorio Marañón, Madrid, España. Electronic address: sanosorio2000@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Osorio
authors.affiliation: Servicio de Hematología, Hospital Virgen de la Salud, Toledo, España.
authors.forename: L F
authors.initials: LF
authors.lastname: Casado
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Zaragoza, España.
authors.forename: P
authors.initials: P
authors.lastname: Giraldo
authors.affiliation: Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IIS-IP), Madrid, España.
authors.forename: B
authors.initials: B
authors.lastname: Maestro
authors.affiliation: Servicio de Hematología, Hospital Miguel Servet, Zaragoza, España.
authors.forename: M
authors.initials: M
authors.lastname: Andrade
authors.affiliation: Servicio de Hematología, Hospital Gregorio Marañón, Madrid, España.
authors.forename: S
authors.initials: S
authors.lastname: Redondo
authors.affiliation: Servicio de Hematología, Hospital Ramón y Cajal, Madrid, España.
authors.forename: V
authors.initials: V
authors.lastname: García-Gutiérrez
authors.affiliation: Servicio de Hematología, Hospital 12 de Octubre, Madrid, España.
authors.forename: R
authors.initials: R
authors.lastname: Ayala
authors.affiliation: Servicio de Hematología, Hospital Virgen de la Salud, Toledo, España.
authors.forename: N
authors.initials: N
authors.lastname: Garcia
authors.affiliation: Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IIS-IP), Madrid, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Steegmann
keywords: Chronic myeloid leukaemia; Epidemiology; Epidemiología; España; Leucemia mieloide crónica; Spain