title: Evolution Profiles of Different Corneal Parameters in Progressive Keratoconus.
abstract: OBJECTIVE
  To analyze the evolution profiles of several corneal topographic and tomographic parameters in progressive keratoconus and compare them with the kinetics of evolution of anterior keratometry.
  
  
  METHODS
  One hundred nine eyes of 55 patients were prospectively enrolled and followed up every 3 months for at least 1 year. Forty-five corneal parameters were measured at each visit using a combined Placido-based and dual Scheimpflug imaging system. Percentage of progression between each visit was calculated for each parameter and comparisons were tested between the different variables.
  
  
  RESULTS
  At 1 year, 11% (12/109) of eyes progressed with an increase in maximum anterior keratometry of 1 D or more. Among these eyes, the posterior maximum keratometry and vertical corneal coma had a significantly higher percentage of progression (P < 0.05) than the maximum anterior keratometry, 5.9%, 27%, and 3.2%, respectively, and occurred significantly earlier than the modifications of the anterior keratometry, at the third-, sixth-, and 12th-month visits, for vertical corneal coma, posterior keratometry, and anterior keratometry respectively.
  
  
  CONCLUSIONS
  Modifications of the posterior surface and corneal vertical coma occurred earlier and were detectable before changes in the anterior keratometry readings in eyes with progressive keratoconus. These parameters may be relevant warning signs when monitoring progressive keratoconus.
authors.affiliation: *Anterior Segment and Refractive Surgery Unit, National Reference Center for Keratoconus, University Center Hospital of Bordeaux, Bordeaux, France; †Ophthalmology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; and ‡Department of Ophthalmology, Federal University of Rio De Janeiro, Rio, Brazil.
authors.forename: Joy
authors.initials: J
authors.lastname: Tellouck
authors.forename: David
authors.initials: D
authors.lastname: Touboul
authors.forename: Marcony R
authors.initials: MR
authors.lastname: Santhiago
authors.forename: Laury
authors.initials: L
authors.lastname: Tellouck
authors.forename: Clement
authors.initials: C
authors.lastname: Paya
authors.forename: David
authors.initials: D
authors.lastname: Smadja
mesh_terms: D000293:Adolescent; D000328:Adult; D003315:Cornea / Q000473:pathology*; D063171:Corneal Pachymetry; D019781:Corneal Topography; D057108:Corneal Wavefront Aberration / Q000175:diagnosis; D003952:Diagnostic Imaging / Q000379:methods; D018450:Disease Progression; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis*; D008297:Male; D011446:Prospective Studies; D055815:Young Adult