title: New analogues of brefeldin A from sediment-derived fungus Penicillium sp. DT-F29.
abstract: Four new analogues of brefeldin A named 7, 7-dimethoxybrefeldin C (3), 6β-hydroxybrefeldin C (4), 4-epi-15-epi-brefeldin A (5), 4-epi-8α-hydroxy-15-epi-brefeldin C (6), together with four known analogues (1, 7-9) were isolated from a fermentation of the sediment-derived fungus Penicillium sp. DT-F29. The structures of these compounds were elucidated on the basis of extensive spectroscopic and chemical methods. In the bioactivity assays, only compounds 1 and 8 showed significant inhibitory activities against human lung adenocarcinoma cell. In addition, compound 1 was first reported for the potent ability to reactivate latent HIV with EC50 value of 0.03 μM.
authors.affiliation: a Institute of Marine Biology & Natural Products, Ocean College , Zhejiang Univesity , Hangzhou , China.
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: Hu
authors.affiliation: a Institute of Marine Biology & Natural Products, Ocean College , Zhejiang Univesity , Hangzhou , China.
authors.forename: Le-Le
authors.initials: LL
authors.lastname: Qin
authors.affiliation: a Institute of Marine Biology & Natural Products, Ocean College , Zhejiang Univesity , Hangzhou , China.
authors.forename: Wan-Jing
authors.initials: WJ
authors.lastname: Ding
authors.affiliation: b State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences , Zhejiang University , Hangzhou , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Institute of Marine Biology & Natural Products, Ocean College , Zhejiang Univesity , Hangzhou , China.
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Ma
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D020126:Brefeldin A / Q000031:analogs & derivatives*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D019015:Geologic Sediments / Q000382:microbiology; D006801:Humans; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D020126:Brefeldin A
keywords: Penicillium; Sediment-derived fungus; antitumour; brefeldin A; latent HIV