title: Metastatic Malignant Phyllodes Tumor of the Breast: An Aggressive Disease-Analysis of 7 Cases.
abstract: Malignant phyllodes tumor (PT) of the breast behaves aggressively and the presentation of distant metastases is varied, ranging from synchronous or short interval commonly to a decade rarely. To assess the clinical and temporal pattern of distant metastases in malignant PTs. A retrospective analysis of patients with Phyllodes tumor of the breast from January, 2001 to November, 2014. There were a total of 167 patients with PT; 49 (29 %) were malignant PT out of which 7 developed distant metastases. Detailed analysis of these 7 patients showed that mean age was 36.71 years (range 28-53 years). Three of the seven patients had additional local recurrences post lumpectomy. The procedure performed were wide local excision with muscle reconstruction (n = 1), lumpectomy (n = 1) and mastectomy (n = 5). The distant metastases were synchronous (n = 2) and other 5 had metastases developing within 2 months to 13 years. The sites for distant metastases included lung, brain, adrenal, para-aortic nodes and bone. Six patients received palliative chemotherapy (CT) and 2 also had radiation therapy for brain metastasis. Only 1 patient is alive and receiving CT and all others succumbed to the disease. Patients with malignant PT of the breast with distant metastases behave aggressively and have a dismal outcome with rare exceptions. They need multimodality therapy and close follow up. Newer targeted therapies may have a role to improve the outcome.
authors.affiliation: Endocrine and Breast Surgery Department, Christian Medical College, Vellore, 632004 Tamil Nadu India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Ramakant
authors.affiliation: Radiation Oncology Department, Christian Medical College, Vellore, India.
authors.lastname: Selvamani
authors.affiliation: Pathology Department, Christian Medical College, Vellore, India.
authors.forename: Marie M
authors.initials: MM
authors.lastname: Therese
authors.affiliation: Endocrine and Breast Surgery Department, Christian Medical College, Vellore, 632004 Tamil Nadu India.
authors.forename: M J
authors.initials: MJ
authors.lastname: Paul
keywords: Distant metastases; Malignant phyllodes tumor of breast