title: Metal free C-H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1.
abstract: Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species via C-H functionalization. The optimized conditions represent a metal-free method for the activation of aryl/heteroarylboronic acids, which undergo coupling with diazines and related heteroarenes. Optimized conditions also find application in the synthesis of a pyrimidine-based potent CDK inhibitor, meriolin1.
authors.affiliation: Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine and Academy of Scientific and Innovative Research, Canal Road, Jammu 180001, India. ppsingh@iiim.ac.in.
authors.forename: Thanusha
authors.initials: T
authors.lastname: Thatikonda
authors.forename: Umed
authors.initials: U
authors.lastname: Singh
authors.forename: Srinivas
authors.initials: S
authors.lastname: Ambala
authors.forename: Ram A
authors.initials: RA
authors.lastname: Vishwakarma
authors.forename: Parvinder Pal
authors.initials: PP
authors.lastname: Singh