title: Serum levels of HMGB1 have a diagnostic role in metastatic renal cell cancer.
abstract: RCC constitutes approximately 90% of all renal malignancies and 2-3% of all malignant tumours in adults. In spite of the improvement in radiologic methods, nearly 30% of the early metastatic RCC patients are incidentally diagnosed. HMGB1 is an extracellular signalling molecule that plays a role both in inflammation and carcinogenesis. Patients who were followed in Medical Oncology Departments of Denizli Government Hospital and Antalya Education and Research Hospital with a histopathological diagnosis of RCC between years 2010-2012 were enrolled in this study. HMGB1 levels were also assessed in a manually performed quantitative sandwich-enzyme-linked immunosorbent assay (ELISA) assay kit. In our study, we showed that the serum level of HMGB1, whether 149.9 pg/ml or not is important in differential diagnosis between patient and control group.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Kargı
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Demirpençe
authors.forename: Şeyda
authors.initials: Ş
authors.lastname: Gündüz
authors.forename: Sevil
authors.initials: S
authors.lastname: Göktaş
authors.forename: Arsenal Sezgin
authors.initials: AS
authors.lastname: Alikanoǧlu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yıldırım
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000175:diagnosis*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012372:ROC Curve
chemical_list: D024243:HMGB1 Protein
keywords: Elisa; Renal cell cancer; diagnosis; high mobility group box (HMGB) proteins