title: Increased osteopontin protein expression may be correlated with poor prognosis in non-small-cell lung cancer: A meta analysis.
abstract: OBJECTIVE
  The present meta-nalysis investigates the prognostic value of osteopontin. (OPN) expression in patients with non-small-cell lung cancer. (NSCLC).
  
  
  METHODS
  The Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013) were searched, without language restrictions, to retrieve studies related to OPN and NSCLC. We compiled carefully selected data and a meta-analysis was conducted using STATA software (Version 12.0, Stata Corporation, and College Station, Texas USA). Hazard ratios (HR) with corresponding 95% confidence interval (95%CI) were calculated.
  
  
  RESULTS
  Ten clinical cohort studies were selected for statistical analysis, representing a total of 1,133 NSCLC patients. The main findings of our meta-analysis are that patients who were OPN-positive had significantly shorter overall survival than OPN-negative patients. (HR = 1.47, 95%CI = 1.15. ~ 1.79,P< 0.001). Ethnicity.stratified analysis revealed a significant correlation between expression levels of OPN and poor prognosis of NSCLC patients among both Caucasians and Asians. (Asians: HR = 1.53, 95%CI = 0.95. ~ 2.11, P < 0.001; Caucasians: HR = 1.56, 95%CI = 1.08. ~ 2.03, P < 0.001; respectively).
  
  
  CONCLUSIONS
  The present meta-analysis is consistent with the hypothesis that increased expression of OPN protein may be significantly associated with poor prognosis in patients with NSCLC.
authors.forename: Shao-Min
authors.initials: SM
authors.lastname: Shi
authors.forename: Zhen-Bo
authors.initials: ZB
authors.lastname: Su
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Du-Juan
authors.initials: DJ
authors.lastname: Yu
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Tu
authors.forename: Jing Qian
authors.initials: JQ
authors.lastname: Zhu
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Sheng
authors.forename: Sai-Bin
authors.initials: SB
authors.lastname: Wang
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Sheng
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Chen
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Tian
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, China-Japan Union Hospital of JiLin University, Changchun 130031, Jilin Province, P.R.China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053495:Osteopontin / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D040901:Proteomics; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D053495:Osteopontin