title: SCAP links glucose to lipid metabolism in cancer cells.
abstract: We recently uncovered that glucose is a critical activator of sterol regulatory element-binding proteins (SREBPs). Glucose promotes SREBP-cleavage activating protein (SCAP)/SREBP complex trafficking from the ER to the Golgi and subsequent SREBP activation via N-glycosylation of SCAP. Our study also demonstrated that SCAP plays a critical role in tumor growth.
authors.affiliation: Department of Radiation Oncology, The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio 43210.
authors.forename: Deliang
authors.initials: D
authors.lastname: Guo
keywords: N-glycosylation; SCAP; SREBPs; glioblastoma; glucose; lipid metabolism; tumor growth