title: Antimicrobial Diterpenoids of Wedelia trilobata (L.) Hitchc.
abstract: Continued interest in the metabolites of Wedelia trilobata (L.) Hitchc, a notoriously invasive weed in South China, led to the isolation of twenty-six ent-kaurane diterpenoids, including seven new ones 1-7. Their structures and relative configuration were elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR experiments. The antimicrobial activities of all isolated diterpenoids were evaluated against a panel of bacteria and fungi.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. lisf@sxu.edu.cn.|Institute of Molecular Science, Shanxi University, Taiyuan 030006, China. lisf@sxu.edu.cn.
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. djyjolly@163.com.
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Ding
authors.affiliation: Shanxi Zhendong Pharmaceutical Co., Ltd., Changzhi 047100, China. sarahlyt@163.com.
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. haoxj@mail.kib.ac.cn.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. lisl@mail.kib.ac.cn.
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002681:China; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D031209:Wedelia / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D045786:Diterpenes, Kaurane; D010936:Plant Extracts
keywords: Wedelia trilobata; antimicrobial; ent-kaurane diterpenoids; invasive weed