title: A continuum theory for multicomponent chromatography modeling.
abstract: A continuum theory is proposed for modeling multicomponent chromatographic systems under linear conditions. The model is based on the description of complex mixtures, possibly involving tens or hundreds of solutes, by a continuum. The present approach is shown to be very efficient when dealing with a large number of similar components presenting close elution behaviors and whose individual analytical characterization is impossible. Moreover, approximating complex mixtures by continuous distributions of solutes reduces the required number of model parameters to the few ones specific to the characterization of the selected continuous distributions. Therefore, in the frame of the continuum theory, the simulation of large multicomponent systems gets simplified and the computational effectiveness of the chromatographic model is thus dramatically improved.
authors.affiliation: Institute of Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: David
authors.initials: D
authors.lastname: Pfister
authors.affiliation: Institute of Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland. Electronic address: morbidelli@chem.ethz.ch.
authors.forename: Massimo
authors.initials: M
authors.lastname: Morbidelli
authors.affiliation: Ypso-Facto, 10 Viaduc Kennedy, 54000 Nancy, France.
authors.forename: Roger-Marc
authors.initials: RM
authors.lastname: Nicoud
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D045424:Complex Mixtures / Q000737:chemistry; D008962:Models, Theoretical
chemical_list: D045424:Complex Mixtures
keywords: Chromatography modeling; Complex mixtures; Continuous approach; Linear chromatography