title: Peripheral vestibular pathology in Mondini dysplasia.
abstract: In this study, our objective was to histopathologically analyze the peripheral vestibular system in patients with Mondini dysplasia.
  
  
  
  Comparative human temporal bone study.
  
  
  
  We assessed the sensory epithelium of the human vestibular system with a focus on the number of type I and type II hair cells, as well as the total number of hair cells. We compared those numbers in our Mondini dysplasia group versus our control group.
  
  
  
  The loss of type I and type II hair cells in the cristae of the superior, lateral, and posterior semicircular canals, as well as in the saccular and utricular macula, was significantly higher in our Mondini dysplasia group than in our control group. The total number of hair cells significantly decreased in the cristae of the superior, lateral, and posterior semicircular canals, as well as in the saccular and utricular macula, in our Mondini dysplasia group.
  
  
  
  Loss of vestibular hair cells can lead to vestibular dysfunction in patients with Mondini dysplasia.
  
  
  
  NA Laryngoscope, 127:206-209, 2017.
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A.|Department of Otolaryngology-Head and Neck Surgery, Gebze Fatih State Hospital, Gebze, Kocaeli, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kaya
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A.|Department of Otolaryngology-Head and Neck Surgery, Giresun A. Ilhan Ozdemir State Hospital, Giresun, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Hızlı
authors.affiliation: Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, U.S.A.
authors.forename: Fatıma Kübra
authors.initials: FK
authors.lastname: Kaya
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A.|Department of Otolaryngology-Head and Neck Surgery, Banco de Olhos de Sorocaba Hospital, Sorocaba, São Paulo, Brazil.
authors.forename: Rafael DaCosta
authors.initials: RD
authors.lastname: Monsanto
authors.affiliation: Paparella Ear Head and Neck Institute, Minneapolis, Minnesota, U.S.A.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A.
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
mesh_terms: D000015:Abnormalities, Multiple; D002102:Cadaver; D002675:Child, Preschool; D003051:Cochlea / Q000002:abnormalities*; D005260:Female; D018069:Hair Cells, Vestibular / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013701:Temporal Bone / Q000473:pathology*
keywords: Mondini dysplasia; crista; histopathology; human temporal bone; lateral semicircular canal; macula; posterior semicircular canal; saccule; superior semicircular canal; utricle; vestibular hair cell