title: Overexpression of Anillin (ANLN) is correlated with colorectal cancer progression and poor prognosis.
abstract: BACKGROUND
  Our previous study found ANLN was over-expressed in colorectal cancer(CRC), however the role of ANLN in CRC remained unknown.
  
  
  OBJECTIVE
  To investigate the relationship of ANLN expression in CRC with clinical features and to determinate the prognostic significance of ANLN expression in CRC.
  
  
  METHODS
  The ANLN expression in CRC tissue and adjacent normal colorectal mucosa were measured, the relationship between ANLN expression and clinical features as well as overall survival were analyzed.
  
  
  RESULTS
  ANLN was overexpressed in CRC. ANLN expression was associated with tumor invasion and enlarged tumor size. Furthermore, Kaplan-Meier survival analysis revealed that higher expression of ANLN was associated with poorer overall survival. Multi-variate analysis suggested that higher expression of ANLN, preoperative CEA level and distant metastasis were independent prognostic factor in patients with CRC.
  
  
  CONCLUSIONS
  ANLN expression is elevated in CRC and has a strong potential to act as a biomarker for the prognosis of CRC.
authors.affiliation: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Shanghai Colorectal Cancer Research Center, Shanghai, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Wang
authors.affiliation: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Shanghai Colorectal Cancer Research Center, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.affiliation: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Shanghai Colorectal Cancer Research Center, Shanghai, China.
authors.forename: Long
authors.initials: L
authors.lastname: Cui
authors.affiliation: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Shanghai Colorectal Cancer Research Center, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Shanghai Colorectal Cancer Research Center, Shanghai, China.
authors.forename: Xuguang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Shanghai Colorectal Cancer Research Center, Shanghai, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Fu
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis
chemical_list: C000591059:ANLN protein, human; D014408:Biomarkers, Tumor; D008840:Microfilament Proteins
keywords: ANLN; Colorectal cancer; prognosis