title: Biomedical Potential of Ultrafine Ag/AgCl Nanoparticles Coated on Graphene with Special Reference to Antimicrobial Performances and Burn Wound Healing.
abstract: In recent years, researchers have proven the release of silver ions (Ag(+)) from silver nanoparticles (Ag NPs) significantly affects their toxicity to bacteria and other organisms. Due to the difficulty in maintaining a steady flux of a high concentration of Ag(+), it is still challenging to develop a highly efficient, stable, and biocompatible Ag NP-based antimicrobial material. To circumvent this issue, we developed a new Ag-based bactericide through the fabrication of sunlight-driven and ultrafine silver/silver chloride anchored on reduced graphene oxide (Ag/AgCl/rGO). This stable Ag/AgCl nanophotocatalyst with negligible release of Ag(+) generated a high amount of oxidative radicals, killing the bacteria, thus achieving both high bactericidal efficiency and stability. Moreover, functionalization of the nanomaterial with poly(diallyldimethylammonium chloride) (PDDA) gives it a highly adsorptive capacity, which allows it to capture the bacteria and possibly enhances the bactericidal activity. In vivo histopathological studies showed that the Ag/AgCl/rGO nanomaterial could obviously promote the regeneration of the epidermis, which indicated the good biomedical potential of Ag/AgCl/rGO nanomaterial in burn wound healing.
authors.affiliation: School of Mechanical and Materials Engineering, Washington State University , Pullman, Washington 99164-2920, United States.
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ru
authors.initials: R
authors.lastname: Chen
authors.forename: Tingting
authors.initials: T
authors.lastname: He
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.affiliation: School of Mechanical and Materials Engineering, Washington State University , Pullman, Washington 99164-2920, United States.
authors.forename: Dan
authors.initials: D
authors.lastname: Du
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.forename: Xiaonong
authors.initials: X
authors.lastname: Cheng
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Shi
authors.affiliation: School of Mechanical and Materials Engineering, Washington State University , Pullman, Washington 99164-2920, United States.
authors.forename: Yuehe
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use; D002056:Burns / Q000188:drug therapy; D049109:Cell Proliferation / Q000187:drug effects; D006108:Graphite / Q000737:chemistry*; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D050296:Microbial Viability / Q000187:drug effects; D012834:Silver / Q000494:pharmacology* / Q000627:therapeutic use; D018030:Silver Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D018030:Silver Compounds; D012834:Silver; D006108:Graphite; C037548:silver chloride
keywords: Ag/AgCl; antimicrobial properties; burn wound healing; graphene; oxidative radicals