title: Evaluation of IL-1β, IL-1ra, and IL-10 levels and outcome of periodontal therapy in chronic periodontitis with familial Mediterranean fever.
abstract: OBJECTIVE
  This study aimed to examine the IL-1β, IL-1ra, and IL-10 cytokine levels in gingival crevicular fluid (GCF) and serum of familial Mediterranean fever (FMF) and chronic periodontitis (CP) patients, and their response to nonsurgical periodontal therapy.
  
  
  METHODS
  A total of 50 patients, 15 FMF patients with generalized chronic periodontitis (FMF-CP), 15 systemically healthy patients with generalized chronic periodontitis (CP), ten systemically and periodontal healthy controls (HC), and ten periodontally healthy FMF patients (FMF-HC) were enrolled in the study. The cytokine levels in GCF and serum were determined by ELISA. Probing depth, clinical attachment level, and gingival and plaque indices in each participant were also measured. The GCF and clinical parameters at baseline and 6 weeks were recorded.
  
  
  RESULTS
  The study indicated statistically significant healing of the clinical parameters in both FMF-CP and CP groups after periodontal treatment. GCF IL-1β levels at 6 weeks in FMF-CP group were significantly lower than the CP group (p < 0.05), and GCF IL-1ra levels were significantly decreased at 6 week in the FMF-CP group (p < 0.05). GCF IL-10 levels were significantly higher in the FMF-CP group than in the other groups at baseline and 6 weeks (p < 0.05). There were no significant differences in serum-IL-1β, IL-1ra, and IL-10 levels either FMF-CP or CP groups at baseline or 6 weeks (p > 0.05).
  
  
  CONCLUSIONS
  The results of our study suggested that there was a positive correlation between gingival inflammation and serum cytokine levels in FMF patients and also colchicine treatment showed protective effects on GCF cytokine levels in FMF-CP group.
  
  
  CONCLUSIONS
  Following treatment, GCF IL-1β and GCF IL-1ra levels were decreased in FMF-CP group. GCF IL-10 levels were increased in FMF-CP group compared to other groups. Also, the serum cytokine levels associated with periodontal inflammation in FMF patients.
authors.affiliation: Department of Periodontology, Cumhuriyet University Faculty of Dentistry, 58140, Sivas, Turkey. dtvildanbostanci@hotmail.com.
authors.forename: Vildan
authors.initials: V
authors.lastname: Bostanci
authors.affiliation: Department of Periodontology, Cumhuriyet University Faculty of Dentistry, 58140, Sivas, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Toker
authors.affiliation: Department of Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Senel
authors.affiliation: Department of Microbiology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Poyraz
authors.affiliation: Department of Periodontology, Cumhuriyet University Faculty of Dentistry, 58140, Sivas, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Akpinar
authors.affiliation: Department of Periodontology, Cumhuriyet University Faculty of Dentistry, 58140, Sivas, Turkey.
authors.forename: Emine Pirim
authors.initials: EP
authors.lastname: Görgün
authors.affiliation: Department of Periodontology, Cumhuriyet University Faculty of Dentistry, 58140, Sivas, Turkey.
authors.forename: Olcay
authors.initials: O
authors.lastname: Bakar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000378:metabolism* / Q000628:therapy*; D003078:Colchicine / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D010505:Familial Mediterranean Fever / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism*; D008297:Male; D010512:Periodontal Index; D050257:Tubulin Modulators / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D050257:Tubulin Modulators; D016753:Interleukin-10; D003078:Colchicine
keywords: Chronic periodontitis; Familial Mediterranean fever; Gingival crevicular fluid; Interleukines