title: Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts.
abstract: Aurantiamide and aurantiamide acetate are the main active constituents of purslane (Portulaca oleracea L.), an edible plant with various biological activities. In this study, we developed a validated UHPLC-MS/MS method to quantitate the concentrations of aurantiamide and aurantiamide acetate in the plasma and various organ tissues of rat as the basis to study their pharmacological profile and distribution in vivo. Aurantiamide and aurantiamide acetate were rapidly absorbed following oral administration, both achieving a Cmax at around 0.2 h. The extent of their metabolisms also varied among different organ tissues, resulting in about 90% reduction in concentrations 4 h after their administration, thus leaving no long-term accumulation in the tissues. This is the first study to examine the pharmacokinetic and biodistribution of aurantiamide and aurantiamide acetate in rat, and our work may serve as the first step toward the investigation of the underlying mechanisms associated with the biological activity of purslane.
authors.forename: Lijiang
authors.initials: L
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Dechao
authors.initials: D
authors.lastname: Jia
authors.forename: Jia
authors.initials: J
authors.lastname: Yang
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Changlan
authors.initials: C
authors.lastname: Chen
authors.affiliation: Research Center for Computer Simulating and Information Processing of Bio-macromolecules of Liaoning Province , Shenyang 110036, People's Republic of China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Liu
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004151:Dipeptides / Q000493:pharmacokinetics*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D031822:Portulaca / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D004151:Dipeptides; D010936:Plant Extracts; C574018:aurantiamide
keywords: Portulaca oleracea L.; UHPLC-MS/MS; aurantiamide and aurantiamide acetate; pharmacokinetic and biodistribution