title: Evaluation of ameliorative potential of supranutritional selenium on enrofloxacin-induced testicular toxicity.
abstract: The study was designed to assess the ameliorative potential of selenium (Se) on enrofloxacin-induced testicular toxicity in rats. There was a significant decrease in body weight and non-significant decrease in mean testicular weight of enrofloxacin treated rats. In enrofloxacin treated rats, total sperm count and viability decreased where as sperm abnormalities increased. Testicular histopathology revealed dose dependent dysregulation of spermatogenesis and presence of necrotic debris in seminiferous tubules which was marginally improved with Se. Enrofloxacin also produced a dose dependent decrease in testosterone level. The activity of testicular antioxidant enzymes decreased where as lipid peroxidation increased in a dose-dependent manner. Se supplementation partially restored oxidative stress and sperm damage and did not affect the plasma concentrations of enrofloxacin or ciprofloxacain. The results indicate that enrofloxacin produces a dose-dependent testicular toxicity in rats that is moderately ameliorated with supranutritional Se.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India; Department of Veterinary Pharmacology and Toxicology, Indian Veterinary Research Institute, India.
authors.forename: Soya
authors.initials: S
authors.lastname: Rungsung
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India. Electronic address: adi.adilmehraj@gmail.com.
authors.forename: Adil Mehraj
authors.initials: AM
authors.lastname: Khan
authors.affiliation: Department of Veterinary Pathology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
authors.forename: Naresh Kumar
authors.initials: NK
authors.lastname: Sood
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
authors.forename: Satyavan
authors.initials: S
authors.lastname: Rampal
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
authors.forename: Simrat Pal
authors.initials: SP
authors.lastname: Singh Saini
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000633:toxicity*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000097:blood / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D013739:Testosterone / Q000097:blood / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D024841:Fluoroquinolones; D020011:Protective Agents; D000077422:Enrofloxacin; D013739:Testosterone; D012643:Selenium
keywords: Enrofloxacin; Reproductive toxicity; Selenium; Supranutritional