title: Identification of transformation products of antiviral drugs formed during biological wastewater treatment and their occurrence in the urban water cycle.
abstract: The fate of five antiviral drugs (abacavir, emtricitabine, ganciclovir, lamivudine and zidovudine) was investigated in biological wastewater treatment. Investigations of degradation kinetics were accompanied by the elucidation of formed transformation products (TPs) using activated sludge lab experiments and subsequent LC-HRMS analysis. Degradation rate constants ranged between 0.46 L d(-1) gSS(-1) (zidovudine) and 55.8 L d(-1) gSS(-1) (abacavir). Despite these differences of the degradation kinetics, the same main biotransformation reaction was observed for all five compounds: oxidation of the terminal hydroxyl-moiety to the corresponding carboxylic acid (formation of carboxy-TPs). In addition, the oxidation of thioether moieties to sulfoxides was observed for emtricitabine and lamivudine. Antiviral drugs were detected in influents of municipal wastewater treatment plants (WWTPs) with concentrations up to 980 ng L(-1) (emtricitabine), while in WWTP effluents mainly the TPs were found with concentration levels up to 1320 ng L(-1) (carboxy-abacavir). Except of zidovudine none of the original antiviral drugs were detected in German rivers and streams, whereas the concentrations of the TPs ranged from 16 ng L(-1) for carboxy-lamivudine up to 750 ng L(-1) for carboxy-acyclovir. These concentrations indicate an appreciable portion from WWTP effluents present in rivers and streams, as well as the high environmental persistence of the carboxy-TPs. As a result three of the carboxylic TPs were detected in finished drinking water.
authors.affiliation: Federal Institute of Hydrology (BfG), Am Mainzer Tor 1, 56068 Koblenz, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Funke
authors.affiliation: Federal Institute of Hydrology (BfG), Am Mainzer Tor 1, 56068 Koblenz, Germany; Department of Civil & Environmental Engineering of California at Berkeley, Berkeley, CA 94720, United States.
authors.forename: Carsten
authors.initials: C
authors.lastname: Prasse
authors.affiliation: Federal Institute of Hydrology (BfG), Am Mainzer Tor 1, 56068 Koblenz, Germany. Electronic address: ternes@bafg.de.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Ternes
mesh_terms: D000998:Antiviral Agents; D004784:Environmental Monitoring; D012722:Sewage; D014865:Waste Disposal, Fluid; D062065:Wastewater; D058438:Water Cycle; D014874:Water Pollutants, Chemical
chemical_list: D000998:Antiviral Agents; D012722:Sewage; D062065:Wastewater; D014874:Water Pollutants, Chemical
keywords: Antiviral drugs; Drinking water; Environmental stability; Rivers; Streams; Transformation products