title: CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors.
abstract: Colorectal cancer (CRC) is a common malignancy worldwide, and chronic inflammation is a risk factor for CRC. In this study, we carried out a cohort study among the Japanese atomic bomb (A-bomb) survivor population to investigate any association between immune- and inflammation-related gene polymorphisms and CRC. We examined the effects of six single-nucleotide polymorphisms of CD14 and IL18 on relative risks (RRs) of CRC. Results showed that RRs of CRC, overall and by anatomic subsite, significantly increased with increasing radiation dose. The CD14-911A/A genotype showed statistically significant higher risks for all CRC and distal CRC compared with the other two genotypes. In addition, the IL18-137 G/G genotype showed statistically significant higher risks for proximal colon cancer compared with the other two genotypes. In phenotype-genotype analyses, the CD14-911A/A genotype presented significantly higher levels of membrane and soluble CD14 compared with the other two genotypes, and the IL18-137 G/G genotype tended to be lower levels of plasma interleukin (IL)-18 compared with the other two genotypes. These results suggest the potential involvement of a CD14-mediated inflammatory response in the development of distal CRC and an IL18-mediated inflammatory response in the development of proximal colon cancer among A-bomb survivors.
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Statistics, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: John B
authors.initials: JB
authors.lastname: Cologne
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Maki
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Morishita
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: Central Research Laboratory, Hiroshima University Faculty of Dentistry , Hiroshima, Japan.
authors.forename: Ikue
authors.initials: I
authors.lastname: Hayashi
authors.affiliation: Clinical Studies, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Waka
authors.initials: W
authors.lastname: Ohishi
authors.affiliation: Department of Clinical Studies, Radiation Effects Research Foundation , Nagasaki, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Hida
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Seishi
authors.initials: S
authors.lastname: Kyoizumi
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kusunoki
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, University of Tokyo , Tokyo, Japan.
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Nakachi
authors.affiliation: Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Hayashi