title: The roles of Polycomb group proteins in hematopoietic stem cells and hematological malignancies.
abstract: Polycomb group (PcG) proteins are epigenetic regulatory factors that maintain the repression of target gene expression through histone modification. PcG proteins control the repression of genes that regulate differentiation and the cell cycle in the maintenance of hematopoietic stem cells (HSC). Moreover, abnormalities in expression level and mutations in PcG genes have been reported in various types of cancer, including hematological malignancies. In this review, we present an overview of the roles of PcG proteins in HSC and various types of hematological malignancies.
authors.affiliation: Division of Hematological Malignancy, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Takamatsu-Ichihara
authors.affiliation: Division of Hematological Malignancy, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. ikitabay@ncc.go.jp.
authors.forename: Issay
authors.initials: I
authors.lastname: Kitabayashi
mesh_terms: D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000502:physiology; D005786:Gene Expression Regulation; D019337:Hematologic Neoplasms / Q000209:etiology / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D063146:Polycomb-Group Proteins / Q000502:physiology*
chemical_list: D063146:Polycomb-Group Proteins
keywords: Leukemia; Polycomb group proteins; Stem cells; Transcription repression