title: Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis.
abstract: BACKGROUND
  Data on the success rate of sitafloxacin treatment in acute complicated urinary tract infection and pyelonephritis are limited.
  
  
  OBJECTIVE
  To determine the success rate of a new oral fluoroquinolone, sitafloxacin, in acute complicated urinary tract infection and pyelonephritis.
  
  
  METHODS
  A prospective study of 30 patients who were diagnosed with acute complicated urinary tract infection and pyelonephritis was conducted. Oral sitafloxacin 50 mg twice a day was given for 7 days. All patients were followed up at baseline, day 7, and day 14.
  
  
  RESULTS
  The patient sample included 67 % females; the mean ± SD age was 49 ± 13 years. Twenty-one (70 %) patients had acute pyelonephritis and 9 (30 %) had complicated urinary tract infections. Twenty-two patients were positive for uropathogens. The most frequently isolated pathogen was E. coli 11 non-extended spectrum beta-lactamase (ESBL) producing and 5 ESBL-producing strains. Of the 22 isolated uropathogens, 19 (86 %) isolates were sensitive to sitafloxacin. At day 14, 29 of 30 (97 %) were clinically cured and 21 of 22 (95 %) were microbiologically cured. No patients discontinued sitafloxacin due to adverse events.
  
  
  CONCLUSIONS
  These results support the use of oral sitafloxacin in complicated urinary tract infections and acute pyelonephritis. However, further larger studies are required to confirm these results.
authors.affiliation: Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Tiwanon Road, Nonthaburi, 11000 Thailand.
authors.forename: Weerawat
authors.initials: W
authors.lastname: Manosuthi
authors.affiliation: Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Tiwanon Road, Nonthaburi, 11000 Thailand.
authors.forename: Surasak
authors.initials: S
authors.lastname: Wiboonchutikul
keywords: Pyelonephritis; Sitafloxacin; Treatment; Urinary tract infection