title: Time-Delay Mapping of High-Resolution Gastric Slow-Wave Activity.
abstract: Analytic monitoring of electrophysiological data has become an essential component of efficient and accurate clinical care. In the gastrointestinal (GI) field, recent advances in high-resolution (HR) mapping are now providing critical information about spatiotemporal profiles of slow-wave activity in normal and disease (dysrhythmic) states. The current approach to analyze GI HR electrophysiology data involves the identification of individual slow-wave events in the electrode array, followed by tracking and clustering of events to create a spatiotemporal map. This method is labor and computationally intensive and is not well suited for real-time clinical use or chronic monitoring.
  
  
  
  In this study, an automated novel technique to assess propagation patterns was developed. The method utilized time delays of the slow-wave signals which was computed through cross correlations to calculate velocity. Validation was performed with both synthetic and human and porcine experimental data.
  
  
  
  The slow-wave profiles computed via the time-delay method compared closely with those computed using the traditional method (speed difference: 7.2% ± 2.6%; amplitude difference: 8.6% ± 3.5%, and negligible angle difference).
  
  
  
  This novel method provides rapid and intuitive analysis and visualization of slow-wave activity.
  
  
  
  This techniques will find major applications in the clinical translation of acute and chronic HR electrical mapping for motility disorders, and act as a screening tool for detailed detection and tracking of individual propagating wavefronts, without the need for comprehensive standard event-detection analysis.
authors.forename: Niranchan
authors.initials: N
authors.lastname: Paskaranandavadivel
authors.forename: Gregory
authors.initials: G
authors.lastname: OGrady
authors.forename: Leo K
authors.initials: LK
authors.lastname: Cheng
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D000818:Animals; D004576:Electromyography / Q000379:methods; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D009130:Muscle, Smooth / Q000502:physiology*; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013270:Stomach / Q000502:physiology*; D013552:Swine