title: Symptomatic and quality-of-life outcomes after treatment for clinically localised prostate cancer: a systematic review.
abstract: To conduct a systematic review of the risks of short-term outcomes after major treatments for clinically localised prostate cancer. MEDLINE, EMBASE and the Cochrane Library were searched from 2004 to January 2013. Study arms that included ≥100 men with localised prostate cancer in receipt of surgery, radiotherapy or active surveillance and reported symptomatic and quality-of-life (QoL) data from 6 to 60 months after treatment were eligible. Data were extracted by one reviewer and checked by another. In all, 64 studies (80 treatment cohorts) were included. Most were single treatment cohorts from the USA or Europe. Radiotherapy was the most common treatment (40 cohorts, including 31 brachytherapy cohorts) followed by prostatectomy (39 cohorts), with only one active surveillance cohort. Most frequently measured symptoms were urinary, followed by sexual, and bowel; QoL was assessed in only 17 cohorts. Most studies used validated measures, although poor data reporting and differences between studies meant that it was not possible to pool data. Data on the precise impact of short-term symptomatic and QoL outcomes after treatment for localised prostate cancer are of insufficient quality for clear guidance to men about the risks to these aspects of their lives. It is important that future studies focus on collecting core outcomes through validated measures and comply with reporting guidelines, so that clear and accurate information can be derived for men considering screening or treatment for prostate cancer.
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.|The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: Penny F
authors.initials: PF
authors.lastname: Whiting
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.|The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: Theresa H M
authors.initials: TH
authors.lastname: Moore
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Jameson
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.|The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: Philippa
authors.initials: P
authors.lastname: Davies
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Mari-Anne
authors.initials: MA
authors.lastname: Rowlands
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Margaret
authors.initials: M
authors.lastname: Burke
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Beynon
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.|The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: Jelena
authors.initials: J
authors.lastname: Savovic
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.|The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Donovan
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy*; D011788:Quality of Life
keywords: patient-reported outcome measures; prostate cancer; systematic review