title: The clinical severity score of chronic actinic dermatitis correlates with in vivo photoallergic reactions and the immunologic parameters related to a shift towards Th2 immunity from the Th2/Th1 balanced status in patients with chronic actinic dermatitis.
abstract: BACKGROUND
  Chronic actinic dermatitis (CAD) has a more complicated pathogenetic basis than others. The clinical grading system and its correlations with the clinical and immunological parameters still remained to be investigated to define the nature of CAD in a more detailed manner.
  
  
  OBJECTIVE
  We investigated correlations of the clinical severity score of CAD (CSS-CAD) with the clinical and immunological parameters.
  
  
  METHODS
  We evaluated 72 patients with CAD and classified them into three groups according to the CSS-CAD. We analysed total IgE level, peripheral blood (PB) eosinophil count, the ratio of Th2cell (CCR4 + CD4 +) percentage over Th1 cell (CXCR3 + CD4 +) percentage (Th2/Th1) and/or the sum of suppressor/cytotoxic T cells.
  
  
  RESULTS
  The total IgE levels and the percentage of PB eosinophils were higher in the severer group than other groups. A shift towards Th2 from Th2/Th1 balanced status may be affected by total counts of suppressor T cells, and the patient with higher Th2/Th1 ratio than balanced status had the more proportion in the severer CSS-CAD group than other groups.
  
  
  CONCLUSIONS
  The CSS-CAD correlates with total IgE level, PB eosinophil count and a shift towards Th2 immunity from Th2/Th1. So we suggest the Th1/Th2 dysbalance may be affected by the CSS-CAD.
authors.affiliation: Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Dong-Yeob
authors.initials: DY
authors.lastname: Ko
authors.affiliation: Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Seung-Min
authors.initials: SM
authors.lastname: Ha
authors.affiliation: Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Ki-Hoon
authors.initials: KH
authors.lastname: Song
authors.affiliation: Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Kyeong Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Ki-Ho
authors.initials: KH
authors.lastname: Kim
mesh_terms: D002908:Chronic Disease; D017454:Dermatitis, Photoallergic / Q000276:immunology* / Q000473:pathology; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D012720:Severity of Illness Index; D018417:Th1 Cells / Q000276:immunology* / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology
chemical_list: D007073:Immunoglobulin E
keywords: Th2 shift; chronic actinic dermatitis; clinical severity scores of CAD; photoallergic reactions