title: Synthesis, Characterization, and Evaluation of Cytotoxicity of Poly(3-methylene-2-pyrrolidone).
abstract: The homo- and copolymerization of 3-methylene-2-pyrrolidone (3M2P) is introduced. 3M2P is readily polymerized via conventional free radical polymerization, and two reversible deactivation radical polymerization methods including reversible addition-fragmentation (chain) transfer and single-electron-transfer living radical polymerization. Poly(3M2P) has a high thermal stability and a very high glass transition temperature. Poly(3M2P) does not dissolve in most common organic solvents, but it has a high aqueous solubility. Cytotoxicity tests reveal that it is nontoxic to cells, even up to concentrations of 1 mg/mL. This adds poly(3M2P) to the family of water-soluble and biocompatible pyrrolidone-based vinyl polymers.
authors.affiliation: Department of Chemistry and Polymer Science, Stellenbosch University , Private Bag X1, Matieland 7602, South Africa.
authors.forename: Ingrid M
authors.initials: IM
authors.lastname: Heyns
authors.affiliation: Department of Chemistry and Polymer Science, Stellenbosch University , Private Bag X1, Matieland 7602, South Africa.
authors.forename: Rueben
authors.initials: R
authors.lastname: Pfukwa
authors.affiliation: Department of Chemistry and Polymer Science, Stellenbosch University , Private Bag X1, Matieland 7602, South Africa.
authors.forename: Bert
authors.initials: B
authors.lastname: Klumperman
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D007031:Hypothalamus / Q000187:drug effects / Q000473:pathology*; D051379:Mice; D058105:Polymerization; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000737:chemistry*; D012997:Solvents
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011760:Pyrrolidinones; D012997:Solvents; C028537:2-pyrrolidone