title: Administration of Piceatannol Complexed with α-Cyclodextrin Improves Its Absorption in Rats.
abstract: Piceatannol is polyphenolic antioxidant found in passion fruit (Passiflora edulis) seeds. The aim of this study was to improve the absorption of piceatannol using α-cyclodextrin (αCD). The solubility of piceatannol in neutral and acidic solutions increased in an αCD concentration-dependent manner. The maximum plasma concentration of intact piceatannol and the time-to-maximum plasma concentration of O-methylated piceatannol metabolites increased in rats administered αCD-piceatannol inclusion complexes (PICs). Administering the αCD inclusion complexes significantly increased the area under the concentration-time curve of total stilbene derivatives (0-3 h) in terms of the total amount of intact piceatannol, O-methylated piceatannol, conjugated piceatannol, and isorhapontigenin. Gastrointestinal ligation experiments demonstrated that substantially higher levels of piceatannol metabolites were present in the lower intestine (the ileum) at 1 h postintragastric αCD-PICs administration as compared to those observed following piceatannol administration only. These results suggested that αCD enhanced piceatannol movement and absorption in the small intestine.
authors.affiliation: Research Institute, Morinaga & Company, Ltd. , 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, Kanagawa 230-8504, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inagaki
authors.affiliation: Research Institute, Morinaga & Company, Ltd. , 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, Kanagawa 230-8504, Japan.
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Ito
authors.affiliation: Research Institute, Morinaga & Company, Ltd. , 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, Kanagawa 230-8504, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Setoguchi
authors.affiliation: Research Institute, Morinaga & Company, Ltd. , 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, Kanagawa 230-8504, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Oritani
authors.affiliation: Research Institute, Morinaga & Company, Ltd. , 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, Kanagawa 230-8504, Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Ito
mesh_terms: D000818:Animals; D008297:Male; D029598:Passiflora / Q000378:metabolism*; D010936:Plant Extracts / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000378:metabolism*; D012995:Solubility; D013267:Stilbenes / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D047391:alpha-Cyclodextrins / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D013267:Stilbenes; D047391:alpha-Cyclodextrins; C041525:3,3',4,5'-tetrahydroxystilbene; C032613:alpha-cyclodextrin
keywords: absorption; passion fruit; piceatannol; stilbene; α-cyclodextrin