title: Lactulose Hydrogen Breath Test Result Is Associated with Age and Gender.
abstract: Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to lactulose hydrogen breath test (LHBT) result. Methods. A cross-sectional study in a university-based gastroenterology practice was performed. Data was abstracted from the medical records of subjects undergoing LHBT from 6/1/2009 to 6/1/2013. Logistic regression analysis was performed to determine the association between predictor variables: age, sex, body mass index (BMI), and positive LHBT, the outcome of interest. Results. LHBT was performed in 791 subjects. Fifty-four percent had a positive LHBT. There was no statistically significant difference between the LHBT results according to age or BMI. In females, the likelihood of a positive LHBT increased with age (OR 1.02; 95% CI: 1.01-1.03). In males, the likelihood of a positive LHBT result decreased with age (OR 0.98; 95% CI: 0.97-1.00). Conclusion. There was an association between age, with respect to sex, and a positive LHBT. With increased age in females, the odds of a positive LHBT increased, while, in men, the odds of a positive LHBT decreased with age.
authors.affiliation: University of Pennsylvania Perelman School of Medicine, Division of Gastroenterology, Philadelphia, PA 19104, USA.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Newberry
authors.affiliation: University of Pennsylvania Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA 19104, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Tierney
authors.affiliation: University of Pennsylvania Perelman School of Medicine, Division of Gastroenterology, Philadelphia, PA 19104, USA.
authors.forename: Octavia
authors.initials: O
authors.lastname: Pickett-Blakely
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000473:pathology*; D001424:Bacterial Infections / Q000175:diagnosis* / Q000378:metabolism / Q000382:microbiology; D001944:Breath Tests; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics
chemical_list: D007792:Lactulose; D006859:Hydrogen