title: Characterization of Mitogen-Activated Protein Kinase Expression in Nucleus Accumbens and Hippocampus of Rats Subjected to Food Selection in the Cafeteria Diet Protocol.
abstract: Obesity is a world-wide health problem that requires different experimental perspectives to understand the onset of this disease, including the neurobiological basis of food selection. From a molecular perspective, obesity has been related with activity of several endogenous molecules, including the mitogenactivated protein kinases (MAP-K). The aim of this study was to characterize MAP-K expression in hedonic and learning and memory brain-associated areas such as nucleus accumbens (AcbC) and hippocampus (HIPP) after food selection. We show that animals fed with cafeteria diet during 14 days displayed an increase in p38 MAP-K activity in AcbC if chose cheese. Conversely, a diminution was observed in animals that preferred chocolate in AcbC. Also, a decrease of p38 MAP-K phosphorylation was found in HIPP in rats that selected either cheese or chocolate. Our data demonstrate a putative role of MAP-K expression in food selection. These findings advance our understanding of neuromolecular basis engaged in obesity.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sarro-Ramírez
authors.forename: Daniel
authors.initials: D
authors.lastname: Sánchez
authors.forename: Alma
authors.initials: A
authors.lastname: Tejeda-Padrón
authors.forename: Linda Vianey
authors.initials: LV
authors.lastname: Buenfil-Canto
authors.forename: Jorge
authors.initials: J
authors.lastname: Valladares-García
authors.forename: Elda
authors.initials: E
authors.lastname: Pacheco-Pantoja
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión
authors.affiliation: Laboratorio de Neurociencias Moleculares e Integrativas Escuela de Medicina, División Ciencias de la Salud Universidad Anáhuac Mayab Carretera Mérida-Progreso Km. 15.5 A.P. 96 Cordemex C.P. 97310, Mérida, Yucatán. México. eric.murillo@anahuac.mx.
authors.forename: Eric
authors.initials: E
authors.lastname: Murillo-Rodríguez
mesh_terms: D000818:Animals; D026481:Blotting, Far-Western; D002755:Choice Behavior; D005518:Food Preferences / Q000502:physiology*; D006624:Hippocampus / Q000201:enzymology*; D008297:Male; D023421:Models, Animal; D009714:Nucleus Accumbens / Q000201:enzymology*; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D048051:p38 Mitogen-Activated Protein Kinases