title: Disease onset in familial and sporadic multiple sclerosis in Argentina.
abstract: The present study was carried out to assess if there is an anticipation of age at onset in younger generations of familial multiple sclerosis (FMS) vs. sporadic MS (SMS) in Argentina.
  
  
  METHODS
  multicenter study that included patients from 14 MS Centers of Argentina. Patients were considered as FMS if they had in their family at least one relative of first or second degree diagnosed with MS; otherwise, patients were considered to have SMS. We compared the age at onset between familial and sporadic cases as well as the age at onset between relatives from different generations in FMS vs. SMS.
  
  
  RESULTS
  1333 patients were included, 97 of them were FMS (7.3%). A lower age at onset in the younger generations of FMS cases was found compared with older generations of FMS as well as. SMS cases (24.1±3.7 years vs. 30.3±5.7 years, and 32.4±9.4 respectively; p<0.001). No differences were observed between older generations of FMS vs. SMS cases (p=0.12).
  
  
  CONCLUSIONS
  we observed an anticipation of age at onset of MS in younger generations of patients with FMS vs. older generations of FMS and SMS.
authors.affiliation: Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina. Electronic address: juan.rojas@hospitalitaliano.org.ar.
authors.forename: J I
authors.initials: JI
authors.lastname: Rojas
authors.affiliation: Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Patrucco
authors.affiliation: Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: MIguez
authors.affiliation: Instituto de Neurociencias, Fundación Favaloro, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Sinay
authors.affiliation: Instituto de Neurociencias, Fundación Favaloro, Argentina.
authors.forename: F Pagani
authors.initials: FP
authors.lastname: Cassara
authors.affiliation: Neurosciences Institute of Buenos Aires (INEBA), Buenos Aires, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Cáceres
authors.affiliation: Neurosciences Institute of Buenos Aires (INEBA), Buenos Aires, Argentina; Multiple Sclerosis Section Hospital E.Tornú, Buenos Aires, Argentina.
authors.forename: N Fernandez
authors.initials: NF
authors.lastname: Liguori
authors.affiliation: Neurosciences Institute of Buenos Aires (INEBA), Buenos Aires, Argentina; Multiple Sclerosis Section Hospital E.Tornú, Buenos Aires, Argentina.
authors.forename: M L
authors.initials: ML
authors.lastname: Saladino
authors.affiliation: Centro de Investigación DIABAID, Argentina.
authors.forename: N
authors.initials: N
authors.lastname: Deri
authors.affiliation: Centro de Investigación DIABAID, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Jaacks
authors.affiliation: Private Office, Private Office, Argentina.
authors.forename: M Parada
authors.initials: MP
authors.lastname: Marcilla
authors.affiliation: Hospital Italiano de Córdoba, Argentina.
authors.forename: M I
authors.initials: MI
authors.lastname: Arrigoni
authors.affiliation: Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Correale
authors.affiliation: Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Fiol
authors.affiliation: Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Argentina.
authors.forename: M C
authors.initials: MC
authors.lastname: Ysrraelit
authors.affiliation: Hospital Británico Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Carrá
authors.affiliation: Hospital Británico Buenos Aires, Argentina.
authors.forename: M C
authors.initials: MC
authors.lastname: Curbelo
authors.affiliation: Hospital Británico Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Martinez
authors.affiliation: Hospital Británico Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Steinberg
authors.affiliation: Hospital Escuela "José F. De San Martín", Corrientes, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Bestoso
authors.affiliation: Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors.forename: J P
authors.initials: JP
authors.lastname: Hryb
authors.affiliation: Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors.forename: J L
authors.initials: JL
authors.lastname: Di Pace
authors.affiliation: Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors.forename: M B
authors.initials: MB
authors.lastname: Perassolo
authors.affiliation: Hospital Alemán, Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Carnero Contentti
authors.affiliation: Hospital Alemán, Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Caride
authors.affiliation: Hospital Alemán, Buenos Aires, Argentina.
authors.forename: P A
authors.initials: PA
authors.lastname: Lopez
authors.affiliation: Private Office, Private Office, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Martinez
authors.affiliation: Hospital Julio Mendez, Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Reich
authors.affiliation: Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Cristiano
mesh_terms: D000328:Adult; D017668:Age of Onset; D001118:Argentina / Q000453:epidemiology; D005190:Family; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics; D012189:Retrospective Studies; D055815:Young Adult
keywords: Argentina; Familial MS; Multiple sclerosis; South America