title: Acute acalculous cholecystitis in a Lebanese girl with primary Epstein-Barr viral infection.
abstract: Acute acalculous cholecystitis (AAC) constitutes 5-10% of all cases of cholecystitis in adults, and is even less common in children. The recent literature has described an association between primary Epstein-Barr virus (EBV) infection and AAC, however, it still remains an uncommon presentation of the infection. Most authors advise that the management of AAC in patients with primary EBV infection should be supportive, since the use of antibiotics does not seem to alter the severity or prognosis of the illness. Furthermore, surgical intervention has not been described as necessary or indicated in the management of uncomplicated AAC associated with EBV infection. We report a case of a 16-year-old Lebanese girl with AAC associated with primary EBV infection. She presented to the emergency department, with high-grade fever, fatigue, vomiting and abdominal pain. Liver enzymes were elevated with a cholestatic pattern, and imaging confirmed the diagnosis of AAC. She was admitted to the regular floor, and initial management was conservative. Owing to persistence of fever, antibiotics were initiated on day 3 of admission. She had a smooth clinical course and was discharged home after a total of 9 days, with no complications.
authors.affiliation: American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Marianne
authors.initials: M
authors.lastname: Majdalani
authors.affiliation: American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Nadine
authors.initials: N
authors.lastname: Milad
authors.affiliation: American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Zeyad
authors.initials: Z
authors.lastname: Sahli
authors.affiliation: American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Sarah
authors.initials: S
authors.lastname: Rizk
mesh_terms: D042101:Acalculous Cholecystitis / Q000821:virology*; D000293:Adolescent; D041881:Cholecystitis, Acute / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007861:Lebanon