title: Sequencing and molecular modeling identifies candidate members of Caliciviridae family in bats.
abstract: Emerging viral diseases represent an ongoing challenge for globalized world and bats constitute an immense, partially explored, reservoir of potentially zoonotic viruses. Caliciviruses are important human and animal pathogens and, as observed for human noroviruses, they may impact on human health on a global scale. By screening fecal samples of bats in Hungary, calicivirus RNA was identified in the samples of Myotis daubentonii and Eptesicus serotinus bats. In order to characterize more in detail the bat caliciviruses, large portions of the genome sequence of the viruses were determined. Phylogenetic analyses and molecular modeling identified firmly the two viruses as candidate members within the Caliciviridae family, with one calicivirus strain resembling members of the Sapovirus genus and the other bat calicivirus being more related to porcine caliciviruses of the proposed genus Valovirus. This data serves the effort for detecting reservoir hosts for potential emerging viruses and recognize important evolutionary relationships.
authors.affiliation: Virological Research Group, János Szentágothai Research Center, University of Pécs, Pécs, Hungary; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Kemenesi
authors.affiliation: Department of Applied Genomics, Agricultural Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Martonvásár, Hungary.
authors.forename: Ákos
authors.initials: Á
authors.lastname: Gellért
authors.affiliation: Virological Research Group, János Szentágothai Research Center, University of Pécs, Pécs, Hungary; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
authors.forename: Bianka
authors.initials: B
authors.lastname: Dallos
authors.affiliation: Department of Zoology, Hungarian Natural History Museum, Budapest, Hungary; Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Görföl
authors.affiliation: Aggtelek National Park Directorate, Jósvafő, Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Boldogh
authors.affiliation: Department of Zoology, Eszterházy Károly College, Eger, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Estók
authors.affiliation: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Szilvia
authors.initials: S
authors.lastname: Marton
authors.affiliation: Virological Research Group, János Szentágothai Research Center, University of Pécs, Pécs, Hungary; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Oldal
authors.affiliation: Dipartimento di Medicina Veterinaria, Universitá Aldo Moro di Bari, Valenzano, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.affiliation: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Bányai
authors.affiliation: Virological Research Group, János Szentágothai Research Center, University of Pécs, Pécs, Hungary; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary. Electronic address: jakabf@gamma.ttk.pte.hu.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Jakab
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002139:Caliciviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D036022:Capsid Proteins / Q000737:chemistry* / Q000235:genetics; D002685:Chiroptera / Q000821:virology*; D004197:Disease Reservoirs / Q000821:virology*; D005243:Feces / Q000821:virology; D015870:Gene Expression; D016679:Genome, Viral; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008958:Models, Molecular; D010802:Phylogeny; D000072756:Protein Conformation, alpha-Helical; D000072757:Protein Conformation, beta-Strand; D012367:RNA, Viral / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013552:Swine
chemical_list: D036022:Capsid Proteins; D012367:RNA, Viral
keywords: Bat; Calicivirus; Daubenton's bat; Europe; Hungary; Protein modeling; Serotine bat; Virus