title: Increased Exhaled 8-Isoprostane and Interleukin-6 in Patients with Helicobacter pylori Infection.
abstract: BACKGROUND
  Helicobacter pylori (H. pylori) infection triggers both local inflammation, usually in gastric mucosa, and chronic systemic inflammation. It is assumed that this local and systemic inflammation is caused by extracellular products excreted by H. pylori. The aim of this study was to investigate the possible association between H. pylori infection and a local inflammatory response in the airway by using exhaled breath condensate technique.
  
  
  METHODS
  This study includes 41 H. pylori seropositive patients who have gastric symptoms and 27 healthy control subjects. Pulmonary function tests (PFT), chest X ray, and physical examination were performed in all patients and interleukin-6 (IL-6), 8-isoprostane and nitrotyrosine levels were measured in exhaled breath condensate.
  
  
  RESULTS
  Levels of IL-6 and 8-isoprostane in exhaled breath condensate (EBC) were significantly higher in H. pylori positive patients than control subjects (p < 0.05). Nitrotyrosine levels were also higher in H. pylori positive patients but the difference was not statistically significant. Both groups had similar leukocyte counts, C-reactive protein (CRP) levels and PFT parameters.
  
  
  CONCLUSIONS
  H. pylori infection causes an asymptomatic airway inflammation which can be detected by exhaled breath condensate. The clinical importance of this inflammation remains unclear.
authors.affiliation: Department of Pulmonary Medicine, Gazi University School of Medicine, Ankara, Turkey. zekiy@hotmail.com.
authors.forename: Zeki
authors.initials: Z
authors.lastname: Yildirim
authors.affiliation: Department of Pulmonary Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Bozkurt
authors.affiliation: Department of Pulmonary Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Ozol
authors.affiliation: Department of Biochemistry, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ferah
authors.initials: F
authors.lastname: Armutcu
authors.affiliation: Department of Pulmonary Medicine, Ordu University School of Medicine, Ordu, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Akgedik
authors.affiliation: Department of Pulmonary Medicine, Ataturk Chest Disease and Chest Surgery Research and Education Hospital, Konya, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Karamanli
authors.affiliation: Department of Pulmonary Medicine, Hakkari State Hospital, Hakkari, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Kizilirmak
authors.affiliation: Department of Internal Medicine, Tatvan State Hospital, Bitlis, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: İkizek
mesh_terms: D000328:Adult; D001944:Breath Tests; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000032:analysis; D005260:Female; D016481:Helicobacter Infections / Q000473:pathology*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D014443:Tyrosine / Q000031:analogs & derivatives / Q000032:analysis
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; C075750:8-epi-prostaglandin F2alpha; C002744:3-nitrotyrosine; D014443:Tyrosine; D015237:Dinoprost
keywords: Helicobacter pylori; airway; inflammation; oxidative stress