title: Antioxidant Nanocomplexes for Delivery of Epigallocatechin-3-gallate.
abstract: Modification of chitosan (CS) through grafting with caffeic acid (CA, CA-g-CS) and ferulic acid (FA, FA-g-CS) significantly improved its solubility under neutral and alkaline environments. Spherical and physicochemically stable nanocomplexes assembled from the phenolic acid grafting CS and caseinophosphopeptide (CPP) were obtained with particle size <300 nm and zeta potential of <+30 mV. The net polymer nanocomplexes composed with the phenolic acid grafting CS and CPP showed strong antioxidant activity. The encapsulation efficiencies of epigallocatechin-3-gallate (EGCG) in the CA-g-CS-CPP nanocomplexes and FA-g-CS-CPP nanocomplexes were 88.1 ± 6.7 and 90.4 ± 4.2%, respectively. Improved delivery properties of EGCG were achieved after loading with the antioxidant nanocomplexes, including controlling release of EGCG under simulated gastric environments and preventing its degradation under neutral and alkaline environments.
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
authors.forename: Fengguang
authors.initials: F
authors.lastname: Ma
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
authors.forename: Yingkang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
authors.forename: Minhao
authors.initials: M
authors.lastname: Xie
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
authors.forename: Xiaoxiong
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000975:Antioxidants; D002392:Catechin; C045651:epigallocatechin gallate
keywords: EGCG; antioxidant activity; controlled release; nanocomplexes; phenolic acid grafting chitosan