title: Efficacy and Safety of Trabectome Surgery in Chinese Open-Angle Glaucoma.
abstract: To investigate the clinical outcome of the Trabectome in Chinese open-angle glaucoma (OAG). This prospective case series recruited pseudophakic glaucoma subjects with open-angle configuration. Trabeculectomy ab interno was performed using the Trabectome to 120° of the trabecular meshwork. Intraocular pressure (IOP) and medications were recorded preoperatively and every 3 months postoperatively. Visual acuity was measured preoperatively and at 1 and 6 months postoperatively. One-way ANOVA with Tukey Multiple Comparison Test were used to measure the pre and postoperative parameters. In 19 eyes of 19 Chinese subjects, 26.3% were uveitic, 68.4% were primary open-angle glaucoma, and 5.3% had a history of chronic angle-closure glaucoma with open-angles after cataract extraction. The subjects' mean age was 67.5 ± 14.4 years, with 4 females and 15 males. Two patients required secondary filtration procedure. At 6 months, the IOP reduced by 34.8% (24.4 ± 4.4 mm Hg to 15.9 ± 5.1 mm Hg, P < 0.0001). The number of types of antiglaucoma medications was reduced by 28.2% (3.9 ± 0.8-2.8 ± 1.6, P < 0.0001). The visual acuity was static at 1 and 6 months postoperatively (P = 0.4). There were no intraoperative complications. 26.3% of subjects had a transient IOP spike > 21 mm Hg, 1 had hyphema requiring washout, and 1 had reactivation of herpetic keratitis. The success rate at 6 months was 89.5%. Trabectome achieved a modest reduction in IOP and medications in the majority of pseudophakic Chinese OAG eyes.
authors.affiliation: From the Department of Ophthalmology, Caritas Medical Centre (JWYL, DWFY, ST, CYFY); Department of Ophthalmology, The University of Hong Kong (JSML, JWYL); and Dennis Lam & Partners Eye Center, Hong Kong, SAR, China (JWYL).
authors.forename: Jacky W Y
authors.initials: JWY
authors.lastname: Lee
authors.forename: Doris W F
authors.initials: DWF
authors.lastname: Yick
authors.forename: Susanna
authors.initials: S
authors.lastname: Tsang
authors.forename: Can Y F
authors.initials: CYF
authors.lastname: Yuen
authors.forename: Jimmy S M
authors.initials: JSM
authors.lastname: Lai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005260:Female; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014130:Trabeculectomy / Q000295:instrumentation*; D014792:Visual Acuity