title: Exploiting plug-and-play electrochemistry for drug discovery.
abstract: Electrochemistry has emerged as a powerful analytical technique for chemical analysis of living cells, biologically active molecules and metabolites. Electrochemical biosensor, microfluidics and mass spectrometry are the most frequently used methods for electrochemical detection and monitory, which comprise a collection of extremely useful measurement tools for various fields of biology and medicine. Most recently, electrochemistry has been shown to be coupled with nanotechnology and genetic engineering to generate new enabling technologies, providing rapid, selective, and sensitive detection and diagnosis platforms. The primary focus of this review is to highlight the utility of electrochemical strategies and their conjunction with other approaches for drug metabolism and discovery. Current challenges and possible future developments and applications of electrochemistry in drug studies are also discussed.
authors.affiliation: School of Life Sciences, Chongqing University, Chongqing 400044, PR China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Gao
authors.affiliation: GRU Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA30912, USA.|Department of Oral Biology, Dental College of Georgia, Augusta University, Augusta, GA30912, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Teng
mesh_terms: D015374:Biosensing Techniques; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D055664:Electrochemical Techniques; D013058:Mass Spectrometry; D055432:Metabolomics; D044085:Microfluidics; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000378:metabolism; D012680:Sensitivity and Specificity
chemical_list: D004364:Pharmaceutical Preparations
keywords: drug discovery; drug metabolism; electrochemical biosensor; electrochemical mass spectrometry; electrochemical microfluidics; electrochemistry