title: [AN INFLUENCE OF ADEMETIONINE ON AN ENERGY METABOLISM, PROOXIDANT-ANTIOXIDANT SYSTEM IN LIVER, MYOCARDIUM, AND BRAIN OF RATS IN THE PRESENCE OF THE DICHLOROETHANE HEPATITIS].
abstract: The negative changes in an energy metabolism and prooxidant-antioxidant system not only in liver, but also in myocardium and brain of rats are observed in the presence of the toxic dichloroethane hepatitis. An activation of oxidative stress with subsequent damage of cells of target organs due to the free radical mechanism and a disruption of an energy metabolism take place in the case of such pathology. The hepatoprotective medicine Ademetionine restores an energy metabolism, antioxidant system, and the system of oxidative modification of proteins functioning not only in hepatocytes, but in myocardium and brain of rats as well.
authors.forename: G A
authors.initials: GA
authors.lastname: Pogotova
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004734:Energy Metabolism / Q000187:drug effects*; D005025:Ethylene Dichlorides; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005025:Ethylene Dichlorides; D017382:Reactive Oxygen Species; D012436:S-Adenosylmethionine; D000255:Adenosine Triphosphate; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione