title: Different effects of the three polymorphisms on 15q25.1 onlung cancer risk: Evidence from published literatures.
abstract: OBJECTIVE
  Genetic studies have shown a significant association between lung cancer risk and single nucleotide polymorphisms on chromosome 15q25.1. The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent. The aim of meta-analysis was toclarify the link between three polymorphisms and susceptibility to lung cancer.
  
  
  METHODS
  All the relevant data were retrieved by Embase, PubMed, and Web of Science, and then 38 eligible studies were chosen in this meta-analysis.
  
  
  RESULTS
  There was no association of rs16969968 polymorphism with cancer risk in the overall pooled analysis. For the rs1051730 and rs8034191 polymorphisms, the results revealed that the five models were significantlyassociated with elevated risk of cancer. Further stratified analysis indicated that increased risk for lung cancer was foundinthe Caucasian, African American, and Asian population.
  
  
  CONCLUSIONS
  In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
authors.forename: Huiling
authors.initials: H
authors.lastname: Sun
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Pan
authors.forename: Bangshun
authors.initials: B
authors.lastname: He
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Deng
authors.forename: Houqun
authors.initials: H
authors.lastname: Ying
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Xian
authors.initials: X
authors.lastname: Liu
authors.affiliation: Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Shukui
authors.initials: S
authors.lastname: Wang
mesh_terms: D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010770:Phosphotransferases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D009419:Nerve Tissue Proteins; D010770:Phosphotransferases; D011978:Receptors, Nicotinic; C447158:CHRNA5 protein, human; C021405:hydroxylysine kinase