title: Early application of citicoline in the treatment of acute stroke: A meta-analysis of randomized controlled trials.
abstract: This study was to evaluate the efficacy and safety of early application of citicoline in the treatment of patients with acute stroke by meta-analysis. Randomized controlled trials published until May 2015 were electronically searched in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, and China Biology Medicine disc. Two reviewers independently screened the articles and extracted the data based on the inclusion and exclusion criteria. The quality of included articles was evaluated by using Revman5.0, and meta-analysis was performed. The results showed that 1027 articles were obtained in initial retrieval, and finally 7 articles, involving a total of 4039 cases, were included for analysis. The meta-analysis showed that no significant differences were found in the long-term mortality (OR=0.91, 95% CI 0.07 to 1.09, P=0.30), the rate of dependency (OR=1.02, 95% CI 0.87 to 1.24, P=0.85), and the effective rate (OR=0.98, 95% CI 0.84 to 1.14, P=0.82) between citicoline group and control group. The overall rate of adverse events in citicoline group was not significantly different from that in control group (P=0.30). The quality of included articles reached moderate-low level. In conclusion, citicolne cannot reduce long-term mortality and dependence rate in the treatment of acute stroke, and the effective rate of citivoline may be not better than that of controls but with reliable safety.
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Shi
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
authors.forename: Xiao-Cui
authors.initials: XC
authors.lastname: Zhou
authors.affiliation: Department of Pathology, West China Medical Center of Sichuan University, Chengdu, 610000, China.
authors.forename: Xiao-Xue
authors.initials: XX
authors.lastname: Yin
authors.affiliation: Department of General Surgery, West China Medical Center of Sichuan University, Chengdu, 610000, China.
authors.forename: Liang-Liang
authors.initials: LL
authors.lastname: Xu
authors.affiliation: Department of Urology, West China Medical Center of Sichuan University, Chengdu, 610000, China.
authors.forename: Xing-Ming
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. hybai@126.com.
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Bai
mesh_terms: D000368:Aged; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018697:Nootropic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000188:drug therapy*
chemical_list: D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline
keywords: acute stroke; cytidine diphosphate choline; meta-analysis; randomized controlled trials