title: Extrahepatic Complications of Nonalcoholic Fatty Liver Disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver disease that is often associated with the metabolic syndrome. There is a growing awareness that extrahepatic complications occur in individuals with NAFLD, especially an increased risk of cardiovascular disease. Development of diabetes mellitus, chronic kidney disease, colorectal cancer, and endocrinopathies has been linked to NAFLD. This article reviews the extrahepatic complications affecting individuals with NAFLD and the pathogenesis underlying their development.
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, 111 East 210th Street, Rosenthal 2C, Bronx, NY 10467, USA.
authors.forename: Kristina R
authors.initials: KR
authors.lastname: Chacko
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, 111 East 210th Street, Rosenthal 2C, Bronx, NY 10467, USA. Electronic address: JREINUS@montefiore.org.
authors.forename: John
authors.initials: J
authors.lastname: Reinus
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology*; D015217:Cholesterol Ester Storage Disease / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D004700:Endocrine System Diseases / Q000453:epidemiology*; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology
keywords: Cardiovascular disease; Extrahepatic complications; Metabolic syndrome; Nonalcoholic fatty liver disease (NAFLD)