title: Neutrophil/Lymphocyte Ratio, Serum Endocan, and Nesfatin-1 Levels in Patients with Psoriasis Vulgaris Undergoing Phototherapy Treatment.
abstract: BACKGROUND Psoriasis is an autoimmune, inflammatory, and chronic disease. Recent studies have evaluated serum endocan and nesfatin-1 levels in patients with inflammatory disorders. The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker currently used in many diseases. The aim of the present study was to evaluate NLR, serum endocan, and nesfatin-1 levels in psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy treatment and compared to healthy controls. MATERIAL AND METHODS This study was conducted on a total of 88 cases, 39 of which had psoriasis vulgaris and 49 were healthy volunteers. Thirty-nine psoriasis vulgaris patients underwent NB-UVB phototherapy treatment for 3 months. NLR, serum endocan, and nesfatin-1 levels were measured in all psoriasis patients before and after NB-UVB phototherapy and in the control group. RESULTS Compared with the control group, neutrophil count and NLR were significantly higher (p<0.001) in psoriasis patients before NB-UVB phototherapy. Serum endocan levels were significantly correlated with disease activity before treatment. There was no significant difference in NLR, serum endocan, and nesfatin-1 levels in psoriasis patients before and after NB-UVB phototherapy (p>0.05). CONCLUSIONS The current study shows that NLR was higher in psoriasis vulgaris patients when compared with the control group, whereas serum endocan and nesfatin-1 levels were not significantly different. In addition, NB-UVB phototherapy did not affect NLR, serum endocan, or nesfatin-1 levels. Further larger-scale studies are required on this subject.
authors.affiliation: Department of Biochemistry, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.
authors.forename: Aybala
authors.initials: A
authors.lastname: Erek Toprak
authors.affiliation: Department of Dermatology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Ozlu
authors.affiliation: Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.
authors.forename: Tugba Kevser
authors.initials: TK
authors.lastname: Uzuncakmak
authors.affiliation: Department of Biochemistry, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Yalcınkaya
authors.affiliation: Department of Biochemistry, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.
authors.forename: Sadık
authors.initials: S
authors.lastname: Sogut
authors.affiliation: Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.
authors.forename: Ayşe Serap
authors.initials: AS
authors.lastname: Karadag
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood*; D009504:Neutrophils / Q000528:radiation effects*; D000080866:Nucleobindins; D010789:Phototherapy / Q000379:methods*; D011509:Proteoglycans / Q000097:blood*; D011565:Psoriasis / Q000097:blood* / Q000628:therapy*; D014467:Ultraviolet Therapy
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C101134:ESM1 protein, human; C000630650:NUCB2 protein, human; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D011509:Proteoglycans