title: Structural comparison of yeast and human intra-mitochondrial lipid transport systems.
abstract: Mitochondria depend on a tightly regulated supply of phospholipids. The protein of relevant evolutionary and lymphoid interest (PRELI)/Ups1 family together with its mitochondrial chaperones [TP53-regulated inhibitor of apoptosis 1 (TRIAP1)/Mdm35] represents a unique heterodimeric lipid-transfer system that is evolutionary conserved from yeast to man. Recent X-ray crystal structures of the human and yeast systems are compared and discuss here and shed new insight into the mechanism of the PRELI/Ups1 system.
authors.affiliation: Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, U.K.
authors.forename: Xeni
authors.initials: X
authors.lastname: Miliara
authors.affiliation: Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, U.K. s.j.matthews@imperial.ac.uk.
authors.forename: Stephen
authors.initials: S
authors.lastname: Matthews
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D001692:Biological Transport; D018360:Crystallography, X-Ray; D006801:Humans; D008055:Lipids; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D008958:Models, Molecular; D010802:Phylogeny; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D015003:Yeasts / Q000378:metabolism*
chemical_list: C493340:APBB1IP protein, human; D048868:Adaptor Proteins, Signal Transducing; D008055:Lipids; D008565:Membrane Proteins
keywords: PRELI; TRIAP1; Ups1; membranes; mitochondria; phospholipid transport