title: Association between adverse perinatal outcomes and amino acid levels measured with nutrient questionnaire in adolescent pregnancies.
abstract: BACKGROUND
  To evaluate the maternal serum amino acid levels in first trimester adolescent pregnancies by using a new developed dietary questionnaire.
  
  
  METHODS
  A group of 169 pregnant women in the first trimester of their pregnancy were asked to complete the dietary questionnaire. Among all the women, 39 were adolescent pregnancies. The results of the questionnaire were evaluated by a nutrient database program (BeBiS software program) designed to evaluate Turkish traditional foods and commercial processed foods.
  
  
  RESULTS
  There was no statistically significant difference between the groups in terms of body mass index and educational and socio-economic status. The mean age and gravidity was statistically significantly lower in adolescent pregnancies. The mean isoleucine, leucine, lysine, methionine, phenylalanine, tyrosine, threonine, valine, arginine, and proline levels were statistically significantly lower in adolescent pregnancies. Receiver operating characteristic (ROC) curve analysis showed the cut-off values of these amino acids. Of these amino acids; lower values of histidine, serine, and alanine were associated with lower birth weight, and lower values of histidine and alanine were associated with preterm delivery.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first study evaluating the amino acid levels in adolescent pregnancies. According to this study, some amino acid levels were lower in adolescent pregnancies and associated with adverse perinatal outcomes. Further studies with maternal and perinatal outcomes are needed to demonstrate the effects of these amino acids in such pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: aliirfanguzel77@gmail.com.
authors.forename: Ali Irfan
authors.initials: AI
authors.lastname: Guzel
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cinar
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Erkilinc
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Rıfat Taner
authors.initials: RT
authors.lastname: Aksoy
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Omer Hamid
authors.initials: OH
authors.lastname: Yumusak
authors.affiliation: Department of Public Health, School of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Celik
authors.affiliation: Department of Biostatistics, School of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Celik
mesh_terms: D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011253:Pregnancy in Adolescence / Q000097:blood*; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D000596:Amino Acids
keywords: adolescent; amino acid; dietary questionnaire; pregnancy