title: Destination Memory in Korsakoff's Syndrome.
abstract: Context memory, or the ability to remember the context in which an episodic event has occurred (e.g., where and when an event took place), has been found to be compromised in Korsakoff's syndrome. This study examined whether a similar deficit would be observed for destination memory, that is, the ability to remember to whom an information was previously transmitted.
  
  
  
  Patients with Korsakoff's syndrome and healthy controls were instructed to tell proverbs to pictures of celebrities. In a subsequent recognition test, they had to indicate to which celebrity they had previously told the proverbs. Participants also completed a neuropsychological battery including a binding task in which they were required to associate letters with their correspondent locations to assess context memory.
  
  
  
  Results showed worse binding and destination memory in patients with Korsakoff's syndrome than in controls. In the Korsakoff group, destination memory was significantly correlated with and predicted by performances on the binding task.
  
  
  
  The binding process seems to be impaired in Korsakoff's syndrome, a deficit that may account for the destination memory compromise in the syndrome, and probably, for the difficulty to retrieve the "where and when" of an encountered event.
authors.affiliation: UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, CNRS, CHU Lille, University of Lille, Lille, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: El Haj
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.|Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands.|Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Roy P C
authors.initials: RP
authors.lastname: Kessels
authors.affiliation: Clinique de la Mitterie, Lomme, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Matton
authors.affiliation: Clinique de la Mitterie, Lomme, France.
authors.forename: Jean-Eudes
authors.initials: JE
authors.lastname: Bacquet
authors.affiliation: Service d'addictologie, CH Roubaix, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Urso
authors.affiliation: Clinique de la Mitterie, Lomme, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Cool
authors.affiliation: Clinique de la Mitterie, Lomme, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Guidez
authors.affiliation: Service d'addictologie, CH Roubaix, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Potier
authors.affiliation: UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, CNRS, CHU Lille, University of Lille, Lille, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Nandrino
authors.affiliation: UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, CNRS, CHU Lille, University of Lille, Lille, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Antoine
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020915:Korsakoff Syndrome / Q000523:psychology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: Binding; Context Memory; Destination Memory; Episodic Memory; Korsakoff's Syndrome