title: Imbalance in subregional connectivity of the right temporoparietal junction in major depression.
abstract: Major depressive disorder (MDD) involves impairment in cognitive and interpersonal functioning. The right temporoparietal junction (RTPJ) is a key brain region subserving cognitive-attentional and social processes. Yet, findings on the involvement of the RTPJ in the pathophysiology of MDD have so far been controversial. Recent connectivity-based parcellation data revealed a topofunctional dualism within the RTPJ, linking its anterior and posterior part (aRTPJ/pRTPJ) to antagonistic brain networks for attentional and social processing, respectively. Comparing functional resting-state connectivity of the aRTPJ and pRTPJ in 72 MDD patients and 76 well-matched healthy controls, we found a seed (aRTPJ/pRTPJ) × diagnosis (MDD/controls) interaction in functional connectivity for eight regions. Employing meta-data from a large-scale neuroimaging database, functional characterization of these regions exhibiting differentially altered connectivity with the aRTPJ/pRTPJ revealed associations with cognitive (dorsolateral prefrontal cortex, parahippocampus) and behavioral (posterior medial frontal cortex) control, visuospatial processing (dorsal visual cortex), reward (subgenual anterior cingulate cortex, medial orbitofrontal cortex, posterior cingulate cortex), as well as memory retrieval and social cognition (precuneus). These findings suggest that an imbalance in connectivity of subregions, rather than disturbed connectivity of the RTPJ as a whole, characterizes the connectional disruption of the RTPJ in MDD. This imbalance may account for key symptoms of MDD in cognitive, emotional, and social domains. Hum Brain Mapp 37:2931-2942, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
authors.forename: Timm B
authors.initials: TB
authors.lastname: Poeppl
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.|Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Veronika I
authors.initials: VI
authors.lastname: Müller
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.|Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Hoffstaedter
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.|Parietal team, INRIA, Neurospin, Gif-sur-Yvette, France.|Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen, Aachen, Germany.|JARA-BRAIN, RWTH Aachen and Research Centre Jülich, Aachen and Jülich, Germany.
authors.forename: Danilo
authors.initials: D
authors.lastname: Bzdok
authors.affiliation: Department of Physics, Florida International University, Miami, Florida.
authors.forename: Angela R
authors.initials: AR
authors.lastname: Laird
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
authors.forename: Berthold
authors.initials: B
authors.lastname: Langguth
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Rupprecht
authors.affiliation: Department of Neuroradiology, Technische Universität München, Munich, Germany.|Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.|Department of Nuclear Medicine, Technische Universität München, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
authors.affiliation: Department of Neuroradiology, Technische Universität München, Munich, Germany.|Department of Nuclear Medicine, Technische Universität München, Munich, Germany.|Neuroimaging Center, Technische Universität München, Munich, Germany.|Department of Neurology, Technische Universität München, Munich, Germany.
authors.forename: Valentin
authors.initials: V
authors.lastname: Riedl
authors.affiliation: Center for Translational Research in Systems Neuroscience and Psychiatry, Georg August University, Göttingen, Germany.
authors.forename: Roberto
authors.initials: R
authors.lastname: Goya-Maldonado
authors.affiliation: Center for Translational Research in Systems Neuroscience and Psychiatry, Georg August University, Göttingen, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Gruber
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.|Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*
keywords: connectivity; depression; functional magnetic resonance imaging; major depressive disorder; resting state; right temporoparietal junction