title: Decreased Symptoms without Augmented Skin Blood Flow in Subjects with RLS/WED after Vibration Treatment.
abstract: Vascular disturbances leading to tissue hypoxia have been named as a possible cause for RLS/WED. Vibration to the whole body (WBV) in subjects with RLS/WED results in increased skin blood flow (SBF). The aims of this investigation were to (1) determine if a two-week treatment with WBV will decrease symptoms associated with RLS/WED and, (2) if so, determine if the mechanism for improvement in symptoms is related to an increase in SBF, as measured in flux.
  
  
  
  Eleven subjects with RLS/WED underwent 2 weeks of 14-minute intermittent WBV and a 2-week sham treatment in randomized order. Pre and post intervention RLS symptom severity were compared. Baseline SBF was compared between subjects with RLS/WED and an age- and sex-matched control group. A crossover design (aim 1) and a matched case-control design and repeated measures design (aim 2) were used. The data analyses consisted of 2-sample and paired t-tests; where applicable we used a standard crossover design adjustment.
  
  
  
  WBV did significantly decrease symptoms associated with RLS/WED compared to baseline data and compared to sham treatment. The baseline flux was significantly lower in RLS/WED subjects than matched controls, but this deficit was negated with WBV. There was no increase in resting SBF over the 2 weeks of treatment.
  
  
  
  Subjects with RLS/WED have decreased SBF but are able to increase flux to the same level as normal subjects with WBV. A 2-week intervention with WBV decreases symptoms associated with RLS/WED, but this does not seem to be related to an increase in resting SBF.
authors.affiliation: Department of Exercise Sciences; Brigham Young University, Provo, UT.
authors.forename: Ulrike H
authors.initials: UH
authors.lastname: Mitchell
authors.affiliation: Department of Educational Leadership and Foundations; Brigham Young University, Provo, UT.
authors.forename: Sterling C
authors.initials: SC
authors.lastname: Hilton
authors.affiliation: Department of Exercise Sciences; Brigham Young University, Provo, UT.
authors.forename: Erik
authors.initials: E
authors.lastname: Hunsaker
authors.affiliation: Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Ulfberg
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology*; D012148:Restless Legs Syndrome / Q000628:therapy*; D012867:Skin / Q000098:blood supply*; D016896:Treatment Outcome; D014732:Vibration / Q000627:therapeutic use*
keywords: WBV; hypoxia; restless legs syndrome