title: Ten years of HPV vaccines: State of art and controversies.
abstract: The human papillomavirus (HPV) represents one of the most common sexually transmitted infections and it has been related to cervical cancer. The HPV vaccines prevent infection with certain species of HPV associated with the development of cervical cancer or genital warts. We carried out a PubMed search up to 2015 evaluating all randomized studies published in literature. This review discusses the current status of HPVs vaccines on the global market, efficacy, safety profiles, controversies and future vaccine developments. Three HPVs vaccines are currently on the global market: bivalent, quadrivalent and ninevalent. Bivalent and quadrivalent vaccines can protect against almost 70% of cervical HPV-related cancerous and precancerous conditions and the ninevalent vaccine, instead, provides a protection against almost 90%. The use of vaccinations raised several controversies in the last years and, currently, is not possible to establish which type of vaccine is most effective, however all of them are safe.
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Angioli
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy. Electronic address: s.lopez@unicampus.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lopez
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Aloisi
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Terranova
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: De Cicco
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Scaletta
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Stella
authors.initials: S
authors.lastname: Capriglione
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Miranda
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Luvero
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ricciardi
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy; Unit of Obstetrics and Gynecology, Magna Graecia University of Catanzaro, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Montera
authors.affiliation: Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Plotti
mesh_terms: D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D011230:Precancerous Conditions; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control* / Q000821:virology
chemical_list: D053918:Papillomavirus Vaccines
keywords: Bivalent; HPV; Ninevalent; Quadrivalent; Vaccine