title: Onco-IP3Rs Feed Cancerous Cravings for Mitochondrial Ca(2.).
abstract: The uncontrolled proliferation of cancer cells requires functional mitochondrial metabolism, which uses Ca(2+) as a cofactor. IP3 receptors (IP3Rs) from endoplasmic reticulum (ER) Ca(2+) stores provide the supply of Ca(2+) to mitochondria. A new study by Cardenas et al. shows that, in contrast to normal cells, cancer cells critically depend on ER-mitochondrial Ca(2+) fluxes for their survival by sustaining the production of mitochondrial substrates used for nucleotide biosynthesis and proliferation.
authors.affiliation: KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O/N-I Box 802, Herestraat 49, BE-3000 Leuven, Belgium; Leuven Kanker Instituut (LKI), Campus Gasthuisberg O/N-I Box 802, Herestraat 49, BE-3000 Leuven, Belgium. Electronic address: Geert.bultynck@med.kuleuven.be.
authors.forename: Geert
authors.initials: G
authors.lastname: Bultynck
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D017136:Ion Transport / Q000187:drug effects; D047028:Macrocyclic Compounds / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009928:Organ Specificity; D010080:Oxazoles / Q000494:pharmacology; D019289:Pyruvic Acid / Q000378:metabolism / Q000494:pharmacology; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured; D050994:Voltage-Dependent Anion Channels / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D047028:Macrocyclic Compounds; D010080:Oxazoles; D034741:RNA, Small Interfering; D050994:Voltage-Dependent Anion Channels; C034703:mitochondrial calcium uniporter; D015544:Inositol 1,4,5-Trisphosphate; D019289:Pyruvic Acid; C078549:xestospongin B; D055372:AMP-Activated Protein Kinases; D002118:Calcium
keywords: Ca(2+); ITPR; inositol 1,4,5-trisphosphate receptors; mitochondria; tumor metabolism