title: [Intracranial germ cell tumours: A 21-year review].
abstract: BACKGROUND
  Intracranial germ cell tumours are rare in children. They are a heterogeneous group of neoplasms that show different clinical manifestations despite having a common origin.
  
  
  METHODS
  A retrospective analysis was carried out on the epidemiological and histological characteristics, clinical manifestations, and outcomes of 20 patients diagnosed with intracranial germ cell tumours in the Niño Jesús Children's Hospital of Madrid from 1994-2014.
  
  
  RESULTS
  A total of 20 patients were identified: 14 boys and 6 girls. The mean age was 11.1 years (range 2-18 years). Histological confirmation of the diagnosis was obtained in 95% of the patients. Of the 20 patients, 14 were pure germinoma (70%) and 6 non-seminomatous germ cell tumours (30%). The most frequent locations were pineal (45%) and suprasellar (45%). The most frequent clinical symptoms in pineal tumours at diagnosis were headache and vomiting (77.77%), followed by visual disturbances (44.4%). In suprasellar tumours it was polydipsia and polyuria (100%). At diagnosis, 90% of the patients received radiotherapy, and 55% received chemotherapy combined with radiotherapy. There was a relapse in 4 patients (20%), and 3 of them died. Overall survival was 80%; 85.7% for pure germinomas and 60% for non-seminomatous germ cell tumours.
  
  
  CONCLUSIONS
  The most common histological subtype was pure germinoma. Germ cell tumours include heterogeneous disease entities that have a variable prognosis. Thus, an accurate diagnosis is vital for patient counselling and treatment planning.
authors.affiliation: Centro de Salud Lucero, Madrid, España. Electronic address: maria.cormenzana@gmail.com.
authors.forename: María
authors.initials: M
authors.lastname: Cormenzana Carpio
authors.affiliation: Servicio de Neuropediatría, Hospital de General de Villalba, Collado Villalba, Madrid, España.
authors.forename: Daniel
authors.initials: D
authors.lastname: Nehme Álvarez
authors.affiliation: Servicio de Hemato-Oncología Pediátrica, Hospital Infantil Niño Jesús, Madrid, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Hernández Marqúes
authors.affiliation: Servicio de Hemato-Oncología Pediátrica, Hospital Infantil La Paz, Madrid, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pérez Martínez
authors.affiliation: Servicio de Hemato-Oncología Pediátrica, Hospital Infantil Niño Jesús, Madrid, España.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Lassaletta Atienza
authors.affiliation: Servicio de Hemato-Oncología Pediátrica, Hospital Infantil Niño Jesús, Madrid, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Madero López
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies; D013997:Time Factors
keywords: Children; Germ cell tumour; Germinal; Germinoma; Intracraneal; Intracranial; Niños; No germinoma; Non-seminomatous; Pure germinoma