title: High-resolution MEG source imaging approach to accurately localize Broca's area in patients with brain tumor or epilepsy.
abstract: OBJECTIVE
  Localizing expressive language function has been challenging using the conventional magnetoencephalography (MEG) source modeling methods. The present MEG study presents a new accurate and precise approach in localizing the language areas using a high-resolution MEG source imaging method.
  
  
  METHODS
  In 32 patients with brain tumors and/or epilepsies, an object-naming task was used to evoke MEG responses. Our Fast-VESTAL source imaging method was then applied to the MEG data in order to localize the brain areas evoked by the object-naming task.
  
  
  RESULTS
  The Fast-VESTAL results showed that Broca's area was accurately localized to the pars opercularis (BA 44) and/or the pars triangularis (BA 45) in all patients. Fast-VESTAL also accurately localized Wernicke's area to the posterior aspect of the superior temporal gyri in BA 22, as well as several additional brain areas. Furthermore, we found that the latency of the main peak of the response in Wernicke's area was significantly earlier than that of Broca's area.
  
  
  CONCLUSIONS
  In all patients, Fast-VESTAL analysis established accurate and precise localizations of Broca's area, as well as other language areas. The responses in Wernicke's area were also shown to significantly precede those of Broca's area.
  
  
  CONCLUSIONS
  The present study demonstrates that using Fast-VESTAL, MEG can serve as an accurate and reliable functional imaging tool for presurgical mapping of language functions in patients with brain tumors and/or epilepsies.
authors.affiliation: Department of Bioengineering, University of California, San Diego, San Diego, CA, USA.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Huang
authors.affiliation: Department of Radiology, University of California, San Diego, San Diego, CA, USA; Research Services, VA San Diego Healthcare System, San Diego, CA, USA. Electronic address: mxhuang@ucsd.edu.
authors.forename: Ming-Xiong
authors.initials: MX
authors.lastname: Huang
authors.affiliation: Department of Radiology, University of California, San Diego, San Diego, CA, USA.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Ji
authors.affiliation: Research Services, VA San Diego Healthcare System, San Diego, CA, USA.
authors.forename: Ashley Robb
authors.initials: AR
authors.lastname: Swan
authors.affiliation: Research Services, VA San Diego Healthcare System, San Diego, CA, USA.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Angeles
authors.affiliation: Department of Radiology, University of California, San Diego, San Diego, CA, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.affiliation: Westview High School, San Diego, CA, USA.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Huang
authors.affiliation: Department of Radiology, University of California, San Diego, San Diego, CA, USA; Research Services, VA San Diego Healthcare System, San Diego, CA, USA.
authors.forename: Roland R
authors.initials: RR
authors.lastname: Lee
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000503:physiopathology / Q000601:surgery; D065711:Broca Area / Q000503:physiopathology* / Q000601:surgery; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000503:physiopathology / Q000601:surgery; D055815:Young Adult
keywords: Broca; Expressive language; Object-naming task; Receptive language; Wernicke