title: Co-prevalence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer.
abstract: ABSTRAT We recently performed 2 studies viewing the presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human breast cancer in the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in breast cancer in Syrian women. Therefore, and based on our previous studies and present data, we reveal that 35 (32%) of 108 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high grade invasive ductal carcinomas (IDCs) with at least one positive lymph nodes, in comparison with EBV and high-risk HPVs-positive samples, which are low to intermediate grade IDCs, respectively. Future studies are needed to confirm the co-presence and the cooperation effect of these onco-viruses in human breast carcinogenesis and metastasis.
authors.affiliation: a College of Medicine & Biomedical Research Centre, Qatar University , Doha , Qatar.|b Oncology Department , McGill University , Montreal , Quebec , Canada.|c Syrian Research Cancer Centre of the Syrian Society against Cancer , Aleppo , Syria.
authors.forename: Ala-Eddin
authors.initials: AE
authors.lastname: Al Moustafa
authors.affiliation: a College of Medicine & Biomedical Research Centre, Qatar University , Doha , Qatar.
authors.forename: Noor
authors.initials: N
authors.lastname: Al-Antary
authors.affiliation: d Segal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, McGill University , Montreal , Quebec , Canada.
authors.forename: Tahar
authors.initials: T
authors.lastname: Aboulkassim
authors.affiliation: c Syrian Research Cancer Centre of the Syrian Society against Cancer , Aleppo , Syria.|e Department of Pathology , Gaziantep University , Gaziantep , Turkey.|f Department of Pathology , Aleppo University , Aleppo , Syria.
authors.forename: Nizar
authors.initials: N
authors.lastname: Akil
authors.affiliation: b Oncology Department , McGill University , Montreal , Quebec , Canada.|d Segal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, McGill University , Montreal , Quebec , Canada.
authors.forename: Gerald
authors.initials: G
authors.lastname: Batist
authors.affiliation: d Segal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, McGill University , Montreal , Quebec , Canada.
authors.forename: Amber
authors.initials: A
authors.lastname: Yasmeen
mesh_terms: D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology; D044584:Carcinoma, Ductal / Q000150:complications* / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D013593:Syria / Q000453:epidemiology
keywords: EBV; Syrian women; breast cancer; cancer phenotype; high-risk HPV