title: The role of meniscal tissue in joint protection in early osteoarthritis.
abstract: It is widely accepted that partial meniscectomy leads to early onset of osteoarthritis (OA). A strong correlation exists between the amount and location of the resected meniscus and the development of degenerative changes in the knee. On the other hand, osteoarthritic changes of the joint alter the structural and functional integrity of meniscal tissue. These alterations might additionally compromise the limited healing capacity of the meniscus. In young, active patients without cartilage damage, meniscus therapy including partial meniscectomy, meniscus suture, and meniscus replacement has proven beneficial effects in long-term studies. Even in an early osteoarthritic milieu, there is a relevant regenerative potential of the meniscus and the surrounding cartilage. This potential should be taken into account, and meniscal surgery can be performed with the correct timing and the proper indication even in the presence of early OA.
authors.affiliation: Ghent University, De Pintelaan 185, 9000, Ghent, Belgium.
authors.forename: Rene
authors.initials: R
authors.lastname: Verdonk
authors.affiliation: Department of Orthopaedic Surgery, Saarland University Medical Center, Kirrberger Strasse 100, Building 37-38, 66421, Homburg, Saarland, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Madry
authors.affiliation: Department of Radiology, Carmel Medical Center, Haifa, Israel.|Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Nogah
authors.initials: N
authors.lastname: Shabshin
authors.affiliation: Orthopädie und Sportchirurgie, Schloss Puchenau, Karl-Leitl-Str. 1, 4048, Linz-Puchenau, Austria.
authors.forename: Florian
authors.initials: F
authors.lastname: Dirisamer
authors.affiliation: IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.|Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Peretti
authors.affiliation: Centre hospitalier de Versailles, 177, rue de Versailles, 78150, Le Chesnay, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pujol
authors.affiliation: Department of Orthopaedics, University Hospital of Coventry and Warwickshire, Rugby, UK.
authors.forename: Tim
authors.initials: T
authors.lastname: Spalding
authors.affiliation: Antwerp Orthopedic Center, Monica Hospitals, Antwerp, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Verdonk
authors.affiliation: Clinique d'Eich and Sports Medicine Research Laboratory, Department of Orthopaedic Surgery, Centre Hospitalier Luxembourg, Luxembourg Institute of Health, 78 rue d'Eich, 1460, Luxembourg, Luxembourg.
authors.forename: Romain
authors.initials: R
authors.lastname: Seil
authors.affiliation: Dipartimento di Ortopedia - Responsabile di Struttura Semplice di Traumatologia dello, Sport Knee Surgery and Sports Traumatology Ospedale Sacro Cuore - Don Calabria Via Don, Sempreboni, 5, 37024, Negrar Verona, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Condello
authors.affiliation: II Orthopaedic Clinic and Biomechanics Lab, Istituto Ortopedico Rizzoli, Bologna, Italy.
authors.forename: Berardo
authors.initials: B
authors.lastname: Di Matteo
authors.affiliation: Department of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Zellner
authors.affiliation: Department of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany. peter.angele@ukr.de.|Sporthopaedicum Regensburg, Hildegard von Bingen Strasse 1, 93053, Regensburg, Germany. peter.angele@ukr.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Angele
mesh_terms: D002358:Cartilage, Articular; D006801:Humans; D007719:Knee Joint; D008592:Menisci, Tibial / Q000601:surgery* / Q000637:transplantation; D020370:Osteoarthritis, Knee / Q000503:physiopathology; D013536:Suture Techniques; D000070600:Tibial Meniscus Injuries / Q000503:physiopathology / Q000601:surgery*; D054457:Tissue Scaffolds; D014945:Wound Healing
keywords: Allograft; Early OA; Meniscal repair; Meniscus; Partial meniscectomy; Scaffold