title: Inflammatory Lipid Mediators in Common Skin Diseases.
abstract: Lipid mediators play a main role in the complex course of cutaneous inflammatory reactions. They regulate a wide spectrum of cellular processes such as cell proliferation and apoptosis. In the early phase of inflammation, excessive amounts of lipid mediators are released and play a major role in the pathogenesis of skin diseases. Recent data suggest that lipid mediators are able to interfere with the pathogenesis of certain dermatologic diseases, seriously affecting patient quality of life. Acne, psoriasis, and atopic dermatitis are specific examples of skin diseases that may respond to treatment with medication affecting these metabolic pathways. The authors briefly present the current knowledge about the role of lipid mediators in common skin pathologies.
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, Istanbul, Turkey; zekayikutlubay@hotmail.com.
authors.forename: Zekayi
authors.initials: Z
authors.lastname: Kutlubay
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, Istanbul, Turkey.
authors.forename: YalçIn
authors.initials: Y
authors.lastname: Tüzün
authors.affiliation: Dermatology Unit, Kaplan Medical Center, Rechovot, Israel.
authors.forename: Ronni
authors.initials: R
authors.lastname: Wolf
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, Istanbul, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Engin
mesh_terms: D003876:Dermatitis, Atopic / Q000188:drug therapy; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids; D011565:Psoriasis / Q000188:drug therapy; D011788:Quality of Life; D012871:Skin Diseases / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D018836:Inflammation Mediators; D008055:Lipids