title: Identification of unique in-frame deletions in OprD among clinical isolates of Pseudomonas aeruginosa.
abstract: A large percentage of Pseudomonas aeruginosa clinical isolates have been noted to be resistant to carbapenems due to loss of function of the OprD porin, the primary mechanism of entry for carbapenems. Such modifications also substantially abolish the organism's ability to transport arginine. Here we report the identification of an in-frame deletion in oprD which confers carbapenem resistance but is expressed and retains the ability to transport arginine.
authors.affiliation: Infection Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA kosscientific@gmail.com.
authors.forename: Veronica N
authors.initials: VN
authors.lastname: Kos
authors.affiliation: Infection Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: McLaughlin
authors.affiliation: Early Clinical Development Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA 02451, USA.
authors.forename: Humphrey A
authors.initials: HA
authors.lastname: Gardner
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D008958:Models, Molecular; D018272:Porins / Q000737:chemistry / Q000235:genetics*; D011487:Protein Conformation; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000302:isolation & purification; D016364:Reading Frames; D017384:Sequence Deletion
chemical_list: D018272:Porins; C077157:OprD protein, Pseudomonas aeruginosa
keywords: OprD; Pseudomonas aerguinosa; carbapenem resistance; porin