title: Aging and the UPR(ER).
abstract: The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response in the endoplasmic reticulum (UPRER). The ability to activate the UPRERdeclines with age, while its constitutive activation can extend longevity. It also plays complex roles in the onset and progression of many age-related diseases. Understanding how the UPRERchanges with age, and how this impacts upon disease development, may open new therapeutic avenues for the treatment of a range of age-associated diseases. This article is part of a Special Issue entitled SI:ER stress.
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: rtaylor@mrc-lmb.cam.ac.uk.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Taylor
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D056811:Unfolded Protein Response / Q000502:physiology*
keywords: Aging; ER; Neurodegeneration; Proteostasis; UPR