title: Association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with multiple sclerosis in Isfahan population.
abstract: Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in autoimmune diseases. In this study, for the first time, the association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with MS in an Iranian population was considered. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and MS (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS (P = 0.009, OR = 4.08).
authors.affiliation: Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Mazrouei
authors.affiliation: Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Ganjalikhani-Hakemi
authors.affiliation: Department of Cellular & Molecular Biology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Salehi
authors.affiliation: Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Alesahebfosoul
authors.affiliation: Department of Neurosciences, Al-Zahra Hospital, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Etemadifar
authors.affiliation: Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Pouladian
authors.affiliation: Department of Immunology, School of Medicine, Shahrekord University of Medical Science, Sharekord, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Meshkat
authors.affiliation: Department of Molecular Diagnosis, Provincial Health Center, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Nekoueian
authors.affiliation: Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Zarkesh-Esfahani
authors.affiliation: Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Ziyaee-Ghahnaviyeh
mesh_terms: D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D000072596:Hepatitis A Virus Cellular Receptor 1 / Q000235:genetics*; D000072597:Hepatitis A Virus Cellular Receptor 2 / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation; D007492:Iran; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: C491143:HAVCR1 protein, human; C448908:HAVCR2 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D000072597:Hepatitis A Virus Cellular Receptor 2