title: Clinical outcomes of two types of cages used in transforaminal lumbar interbody fusion for the treatment of degenerative lumbar diseases: n-HA/PA66 cages versus PEEK cages.
abstract: This study reports the clinical effects of nano-hydroxyapatite/polyamide66 cages (n-HA/PA66 cages) and compares the clinical outcomes between n-HA/PA66 and polyetheretherketone cages (PEEK cages) for application in transforaminal lumbar interbody fusion (TLIF). A retrospective and case-control study involving 124 patients using n-HA/PA66 cages and 142 patients using PEEK cages was conducted. All patients underwent TLIF and had an average of 2-years of follow-up. The Oswestry Disability Index and Visual Analog Scale were selected to assess the pain of low back and leg, as well as neurological status. The intervertebral space height and segmental angle were also measured to estimate the radiological changes. At the 1-year and final follow-ups, the fusion and subsidence rates were evaluated. There was no significant difference between the two groups regarding clinical and radiological results. At the final follow-up, the bony fusion rate was 92.45 and 91.57 % for the n-HA/PA66 and PEEK groups, respectively, and the subsidence rate was 7.55 and 8.99 %, respectively. The study indicated that both n-HA/PA66 and PEEK cages could promote effective clinical and radiographic outcomes when used to treat degenerative lumbar diseases. The high fusion and low subsidence rates revealed that n-HA/PA66 cages could be an alternative ideal choice as the same to PEEK cages for lumbar reconstruction after TLIF.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China.
authors.forename: Qian-xing
authors.initials: QX
authors.lastname: Deng
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China. ouyunsheng2001@163.com.
authors.forename: Yun-sheng
authors.initials: YS
authors.lastname: Ou
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China.
authors.forename: Zeng-hui
authors.initials: ZH
authors.lastname: Zhao
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China.
authors.forename: Xing
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, YouYi Road 1#, YuZhong District, Chongqing, 400016, People's Republic of China.
authors.forename: Dian-ming
authors.initials: DM
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D001577:Benzophenones; D001672:Biocompatible Materials; D001860:Bone Plates; D017886:Durapatite; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000601:surgery; D007659:Ketones; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009757:Nylons; D011092:Polyethylene Glycols; D011108:Polymers; D012189:Retrospective Studies; D013123:Spinal Fusion / Q000295:instrumentation*; D016896:Treatment Outcome
chemical_list: D001577:Benzophenones; D001672:Biocompatible Materials; D007659:Ketones; D009757:Nylons; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols; D017886:Durapatite