title: EMMPRIN/CD147 is an independent prognostic biomarker in cutaneous melanoma.
abstract: CD147 has been implicated in melanoma invasion and metastasis mainly through increasing metalloproteinase synthesis and regulating VEGF/VEGFR signalling. In this study, the prognostic value of CD147 expression was investigated in a cohort of 196 cutaneous melanomas including 136 consecutive primary malignant melanomas, 30 lymph nodes, 16 in-transit and 14 visceral metastases. A series of 10 normal skin, 10 blue nevi and 10 dermal nevi was used as control. CD147 expression was assessed by immunohistochemistry, and the association of its expression with the clinicopathological characteristics of patients and survival was evaluated using univariate and multivariate statistical analyses. Univariate analysis showed that high CD147 expression was significantly associated with metastatic potential and with a reduced overall survival (P < 0.05 for both) in primary melanoma patients. CD147 expression level was correlated with histological factors which were associated with prognosis: Clark level, ulceration status and more particularly with Breslow index (r = 0.7, P < 10(-8) ). Multivariate analysis retained CD147 expression level and ulceration status as predicting factors for metastasis and overall survival (P < 0.05 for both). CD147 emerges as an important factor in the aggressive behaviour of melanoma and deserves further evaluation as an independent prognostic biomarker.
authors.affiliation: Inserm U 976, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Caudron
authors.affiliation: Inserm U 1165, Paris, France.|Sorbonne Paris Cité, Université Paris Diderot, Paris, France.|Department of Pathology, AP-HP, Hôpital Saint-Louis, Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Battistella
authors.affiliation: Sorbonne Paris Cité, Université Paris Diderot, Paris, France.|INSERM, IAME, UMR 1137, Paris, France.|Department of Biochemistry, AP-HP, Hôpital Saint-Louis, Paris, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Feugeas
authors.affiliation: Department of Dermatology, AP-HP, Hôpital Saint-Louis, Paris, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Pages
authors.affiliation: Sorbonne Paris Cité, Université Paris Diderot, Paris, France.|Department of Dermatology, AP-HP, Hôpital Saint-Louis, Paris, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Basset-Seguin
authors.affiliation: Department of plastic surgery, AP-HP, Hôpital Saint-Louis, Paris, France.
authors.forename: Sarra
authors.initials: S
authors.lastname: Mazouz Dorval
authors.affiliation: EA4340, Versailles University, Boulogne-Billancourt, France.|AP-HP, Ambroise Paré Hospital, Department of Dermatology, Boulogne-Billancourt, France.
authors.forename: Elisa
authors.initials: E
authors.lastname: Funck Brentano
authors.affiliation: AP-HP, Laboratoire de Pharmacologie Biologique, Hôpital Saint-Louis, Paris, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Sadoux
authors.affiliation: AP-HP, Laboratoire de Pharmacologie Biologique, Hôpital Saint-Louis, Paris, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Podgorniak
authors.affiliation: Laboratoire CRRET, CNRS-UMR 7149, Créteil, France.|Université Paris 12, Créteil, France.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Menashi
authors.affiliation: Inserm U 1165, Paris, France.|Sorbonne Paris Cité, Université Paris Diderot, Paris, France.|Department of Pathology, AP-HP, Hôpital Saint-Louis, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Janin
authors.affiliation: Inserm U 976, Paris, France.|Sorbonne Paris Cité, Université Paris Diderot, Paris, France.|Department of Dermatology, AP-HP, Hôpital Saint-Louis, Paris, France.
authors.forename: Céleste
authors.initials: C
authors.lastname: Lebbé
authors.affiliation: Inserm U 976, Paris, France.|Sorbonne Paris Cité, Université Paris Diderot, Paris, France.|AP-HP, Laboratoire de Pharmacologie Biologique, Hôpital Saint-Louis, Paris, France.
authors.forename: Samia
authors.initials: S
authors.lastname: Mourah
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: C497886:BSG protein, human; D014408:Biomarkers, Tumor; D051926:Basigin
keywords: disease-free survival; invasion; melanoma progression; metastasis; overall survival