title: Total Synthesis of Cryptocaryol A by Enantioselective Iridium-Catalyzed Alcohol C-H Allylation.
abstract: The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C-H allylation, which directly generates an acetate-based triketide stereodiad. In 4 previously reported total syntheses, 17-28 steps were required.
authors.affiliation: University of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.
authors.forename: Felix
authors.initials: F
authors.lastname: Perez
authors.affiliation: University of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Waldeck
authors.affiliation: University of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA. mkrische@mail.utexas.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D011753:Pyrones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000498:Allyl Compounds; D011753:Pyrones; C585544:cryptocaryol A; D007495:Iridium
keywords: enantioselective synthesis; iridium; polyketide; total synthesis; transfer hydrogenation