title: NF-κB signaling pathway as target for antiplatelet activity.
abstract: In different nucleated cells, NF-κB has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes. Although platelets lack a nucleus, a number of functional transcription factors are involved in activated platelets, such as NF-κB. In platelet activation NF-κB regulation events include IKKβ phosphorylation, IκBα degradation, and p65 phosphorylation. Multiple pathways contribute to platelet activation and NF-κB is a common pathway in this activation. Therefore, in platelet activation the modulation of NF-κB pathway could be a potential new target in the treatment of inflammation-related vascular disease therapy (antiplatelet and antithrombotic activities).
authors.affiliation: Laboratory of Hematology and Immunology, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile; Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, R09I2001, Talca, Chile. Electronic address: edfuentes@utalca.cl.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fuentes
authors.affiliation: Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors.forename: Armando
authors.initials: A
authors.lastname: Rojas
authors.affiliation: Laboratory of Hematology and Immunology, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile; Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, R09I2001, Talca, Chile. Electronic address: ipalomo@utalca.cl.
authors.forename: Iván
authors.initials: I
authors.lastname: Palomo
mesh_terms: D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000627:therapeutic use*; D015539:Platelet Activation
chemical_list: D016328:NF-kappa B
keywords: NF-κB; PPARs; Platelet activation; RAGE; Thrombin; Toll-like receptors; sCD40L/CD40L