title: Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans.
abstract: A new phosphorylated polyketide, phosphoeleganin (1), has been isolated from the Mediterranean ascidian Sidnyum elegans. Its structure and configuration have been determined by extensive use of 2D NMR and microscale chemical degradation and/or derivatization. Phosphoeleganin (1) inhibited the protein tyrosine phosphatase 1B (PTP1B) activity.
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Imperatore
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Luciano
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Aiello
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Rocco
authors.initials: R
authors.lastname: Vitalone
authors.affiliation: Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Irace
authors.affiliation: Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Santamaria
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zu Chong Zhi Road 555, Shanghai 201203, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zu Chong Zhi Road 555, Shanghai 201203, People's Republic of China.
authors.forename: Yue-W
authors.initials: YW
authors.lastname: Guo
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Menna
mesh_terms: D000818:Animals; D019083:Mediterranean Region; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D014561:Urochordata / Q000737:chemistry*
chemical_list: D061065:Polyketides; C000610612:phosphoeleganin; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1