title: [Analysis of the clinical application of epidermal growth factor ("Heberprot-P") and bioplastic material ("Collost") in treatment of skin and soft tissues defects in patients with diabetic foot syndrome].
abstract: CONCLUSIONS
  Currently, there is increasing the number of diabetic foot patients with tissues defects. The local treatment of this pathology against the backdrop of diabetic angiopathy and polyneuropathy is a topical issue.
  
  
  OBJECTIVE
  Treatment of wound defects in patients with neuroischemic form of diabetic foot syndrome; study of the effectiveness of collagen implants and gene-therapy technologies in wound closure.
  
  
  METHODS
  The comparative study was conducted for analyzing clinical effects of "Heberprot-P" and bioplastic material "Collost" on wound healing process in patients with verified diagnosis "diabetic foot syndrome" on the base of City Clinical Hospital №81(Moscow) and "Diabetic Foot" center (Kazan).
  
  
  RESULTS
  The article shows the availability, methodology, results of combination treatment of wound defects of lower limbs in DFS patients with gen-therapy methods and bioplastic materials based on native type I collagen.
  
  
  CONCLUSIONS
  The use of bioplastic materials based on native type I collagen for treatment of tissue defects in patients with diabetic foot is preferably than the use of epidermal growth factor.
authors.affiliation: Department of Surgical Diseases and Clinical Angiology, Moscow State University of Medicine and Dentistry; City Clinical Hospital #81, Moscow.
authors.forename: M D
authors.initials: MD
authors.lastname: Dibirov
authors.affiliation: Department of Surgical Diseases and Clinical Angiology, Moscow State University of Medicine and Dentistry; City Clinical Hospital #81, Moscow.
authors.forename: R U
authors.initials: RU
authors.lastname: Gadzhimuradov
authors.affiliation: Department of General Surgery, Kazan State Medical University; "Diabetic Foot" Center, Kazan.
authors.forename: K A
authors.initials: KA
authors.lastname: Koreyba
mesh_terms: D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D017719:Diabetic Foot / Q000628:therapy*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D058106:Wound Closure Techniques; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D020099:Coated Materials, Biocompatible; D004815:Epidermal Growth Factor