title: Isolated Splenic Metastases of Her2+++ Gastroesophageal Junction Adenocarcinoma.
abstract: Isolated metastases from gastric adenocarcinoma to the spleen are very infrequent. Usually, there are multiple metastases from gastric cancer, and isolated splenic metastases are very rare [Lam and Tang: Arch Pathol Lab Med 2000;124:526-530] because of certain anatomical and physiological characteristics (e.g., angulation between the splenic artery and celiac trunk, paucity of afferent lymph flow toward the spleen, contractility of the spleen and major immune content). Here, we report 2 cases of isolated splenic metastases from an adenocarcinoma of the gastroesophageal junction, both with long-term survival outcome and overexpression of Her2.
authors.affiliation: Departments of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Sigrand
authors.affiliation: Departments of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Bazin
authors.affiliation: Departments of Surgical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Ewald
authors.affiliation: Departments of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Slimane
authors.initials: S
authors.lastname: Dermeche
authors.affiliation: Departments of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Ries
authors.affiliation: Pathology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Flora
authors.initials: F
authors.lastname: Poizat
authors.affiliation: Departments of Surgical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Guiramand
authors.affiliation: Departments of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Raoul
keywords: Gastric adenocarcinoma; Her2; Isolated splenic metastases