title: Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study.
abstract: OBJECTIVE
  To describe the clinical and visual outcomes of juvenile idiopathic arthritis (JIA)-associated uveitis in adults and to examine risk factors for ongoing inflammation in adulthood.
  
  
  METHODS
  Medical records were reviewed for patients with JIA-associated uveitis who were >16 years old at the final visit (the last visit prior to data collection).
  
  
  RESULTS
  In total, 135 eyes of 77 patients (70 female, 7 male) were included. The mean age of patients at the final visit was 29.72 ± 11.27 years. The number of eyes with visual acuity of ≤20/50 and ≤20/200 at the final visit was 37 (28 %) and 20 (15 %), respectively; at least one ocular complication was present in 72 % of eyes. Band keratopathy was the most frequent complication (42 %), followed by cataract (25 %), posterior synechiae (22 %), maculopathy (22 %), ocular hypertension (13 %), and hypotony (5 %). At the final visit, patients who were >16 years of age at presentation to the Massachusetts Eye Research and Surgery Institution had more ocular complications and a greater degree of vision loss than patients who were ≤16 years of age. Ongoing inflammation at the final visit was noted in 40 patients (52 %). The presence of posterior synechiae, hypotony, cataract at presentation, and a history of cataract surgery prior to presentation were predictive of ongoing inflammation in adulthood in univariate analysis. The presence of hypotony and posterior synechiae at the initial visit were predictive factors in multivariate analysis.
  
  
  CONCLUSIONS
  JIA-associated uveitis may be associated with ongoing inflammation, ocular complications, and severe visual impairment in adulthood. The presence of posterior synechiae and hypotony at the initial visit is predictive of ongoing inflammation.
authors.affiliation: Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA.|Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.|Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Istanbul, Turkey.
authors.forename: Merih
authors.initials: M
authors.lastname: Oray
authors.affiliation: Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Naira
authors.initials: N
authors.lastname: Khachatryan
authors.affiliation: Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA.|Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Ebrahimiadib
authors.affiliation: Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA.|Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.
authors.forename: Khawla
authors.initials: K
authors.lastname: Abu Samra
authors.affiliation: Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA.|Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.
authors.forename: Stacey
authors.initials: S
authors.lastname: Lee
authors.affiliation: Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA. fosters@uveitis.org.|Ocular Immunology and Uveitis Foundation, Waltham, MA, USA. fosters@uveitis.org.|Harvard Medical School, Boston, MA, USA. fosters@uveitis.org.
authors.forename: C Stephen
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000150:complications* / Q000453:epidemiology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009017:Morbidity / Q000639:trends; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D062606:Tertiary Care Centers; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014481:United States / Q000453:epidemiology; D014606:Uveitis, Anterior / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D015354:Vision, Low / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D014792:Visual Acuity; D055815:Young Adult
keywords: Anterior uveitis; Juvenile idiopathic arthritis; Ocular complications