title: Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy.
abstract: BACKGROUND
  Cardiac hypertrophy associated with various cardiovascular diseases results in heart failure and sudden death. A clear understanding of the mechanisms of hypertrophy will benefit the development of novel therapies. Long non-coding RNAs (lncRNAs) have been shown to play essential roles in many biological process, however, whether lncRNA-ROR plays functional roles in the reprogramming of cardiomyocyte remains unclear.
  
  
  RESULTS
  Here we show that lncRNA-ROR plays important roles in the pathogenesis of cardiac hypertrophy. In hypertrophic heart and cardiomyocytes, the expression of lncRNA-ROR is dramatically increased, downregulation of which attenuates the hypertrophic responses. Furthermore, the expression of lncRNA-ROR negatively correlates with miR-133, whose expression is increased when lncRNA-ROR is knocked down. In line with this, overexpression of miR-133 prevents the elevation of lncRNA-ROR and re-expression of ANP and BNP in cardiomyocytes subject to phenylephrine treatment.
  
  
  CONCLUSIONS
  Taken together, our study demonstrates that lncRNA-ROR promotes cardiac hypertrophy via interacting with miR-133, indicating that lncRNA-ROR could be targeted for developing novel antihypertrophic therapeutics.
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Vascular and Thyroid Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation / Q000187:drug effects; D055785:Gene Knockdown Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology; D010656:Phenylephrine / Q000494:pharmacology; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs; C517732:Mirn133 microRNA, mouse; D062085:RNA, Long Noncoding; D010656:Phenylephrine