title: The effects of lauromacrogol injection into rat endometrial cysts: a preliminary experimental study.
abstract: To determine the effectiveness of different concentrations of lauromacrogol injections for the treatment of endometriosis in an experimental animal model and to provide an experimental basis for a pre-clinical application of the drug.
  
  
  
  After autologous transplantation of endometrial tissue, 40 endometrial cysts were successfully established and randomly divided into three groups: a 1 % lauromacrogol injection group, a 0.5 % lauromacrogol injection group, and cysts without intervention (control group). We measured the changes in the volumes of the cysts in each group. We then compared the volumes of the endometrial implants before and after treatment and between the different groups and examined the histological findings.
  
  
  
  A significant difference in the spherical volume was found between the 1 % lauromacrogol injection group (P < 0.05). No significant difference was observed between the volume of the endometrial implants in the 0.5 % lauromacrogol injection group (P > 0.05). Regarding the histopathological observations, in the 1 % lauromacrogol injection group, the epithelia of the cystic implants had atrophied, and the glands had atrophied and were reduced in number. The surrounding stromal tissue had become loose and edematous.
  
  
  
  A 1 % lauromacrogol injection produced significant regression of the endometrial foci compared with a 0.5 % lauromacrogol injection or no treatment in a rat model of endometriosis.
authors.affiliation: Department of Ultrasound, Beijing Friendship Affiliated to Capital Medical University, Beijing, China.|Department of Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. 13693685342@163.com.
authors.forename: LongXia
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Cui-Xia
authors.initials: CX
authors.lastname: Guo
mesh_terms: D000818:Animals; D003560:Cysts / Q000188:drug therapy*; D004195:Disease Models, Animal; D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007267:Injections; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014591:Uterine Diseases / Q000188:drug therapy*
chemical_list: D000077423:Polidocanol; D011092:Polyethylene Glycols
keywords: Endometriosis; Experimental endometriosis models; Lauromacrogol injection; Rats