title: Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris.
abstract: BACKGROUND
  There is increasing evidence to support the relationship between acne vulgaris and diet.
  
  
  OBJECTIVE
  The aim of this study was to investigate possible associations among dietary glycemic index, glycemic load, milk consumption, insulin resistance, and adiponectin levels in the pathogenesis of acne vulgaris.
  
  
  METHODS
  The dietary glycemic index, glycemic load, milk consumption, fasting glucose, insulin, insulin-like growth factor)-1, insulin-like growth factor binding protein-3, adiponectin, and homeostasis model assessment of insulin resistance values of 50 patients with acne vulgaris and 36 healthy control subjects were measured.
  
  
  RESULTS
  Glycemic index and glycemic load levels were significantly higher (P = .022 and P = .001, respectively) and serum adiponectin levels were significantly lower (P = .015) in patients with acne than in the control subjects. There was an inverse correlation between serum adiponectin concentration and glycemic index (P = .049, r = -0.212).
  
  
  CONCLUSIONS
  This study used a cross-sectional design and the study population was limited to young, nonobese adults.
  
  
  CONCLUSIONS
  A high-glycemic-index/-load diet was positively associated with acne vulgaris. Adiponectin may be a pathogenetic cofactor contributing to the development of the disease. Further research on adiponectin levels in patients with acne in terms of development of insulin resistance might be important in this possible relationship.
authors.affiliation: Dermatology Department, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. Electronic address: aksuasli@hotmail.com.
authors.forename: Aslı Aksu
authors.initials: AA
authors.lastname: Çerman
authors.affiliation: Dermatology Department, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ezgi
authors.initials: E
authors.lastname: Aktaş
authors.affiliation: Dermatology Department, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: İlknur Kıvanç
authors.initials: İK
authors.lastname: Altunay
authors.affiliation: Dermatology Department, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: Janset Erkul
authors.initials: JE
authors.lastname: Arıcı
authors.affiliation: Immunology Department, Marmara University Faculty of Medicine, Istanbul, Turkey.
authors.forename: Aysın
authors.initials: A
authors.lastname: Tulunay
authors.affiliation: Endocrinology Department, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: Feyza Yener
authors.initials: FY
authors.lastname: Ozturk
mesh_terms: D000152:Acne Vulgaris / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004032:Diet; D005215:Fasting; D005260:Female; D038321:Glycemic Index; D000067940:Glycemic Load; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D000076222:Mechanistic Target of Rapamycin Complex 1; D008892:Milk; D046912:Multiprotein Complexes / Q000097:blood; D058570:TOR Serine-Threonine Kinases / Q000097:blood; D055815:Young Adult
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; C515497:IGFBP3 protein, human; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D046912:Multiprotein Complexes; D007334:Insulin-Like Growth Factor I; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases
keywords: acne vulgaris; adiponectin; forkhead box class O1; glycemic index; glycemic load; insulin resistance; insulin-like growth factor binding protein-3; insulin-like growth factor-1; mammalian target of rapamycin complex-1; milk consumption