title: The role of adiponectin in obesity-associated female-specific carcinogenesis.
abstract: Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.
authors.affiliation: Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India. Electronic address: pganji@emory.edu.
authors.forename: Ganji Purnachandra
authors.initials: GP
authors.lastname: Nagaraju
authors.affiliation: Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Microbiology, Banasthali University, Banasthali, Rajasthan 304022, India. Electronic address: rajitha.balney@wellstar.org.
authors.forename: Balney
authors.initials: B
authors.lastname: Rajitha
authors.affiliation: Department of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh 500085, India. Electronic address: biotechaliya@gmail.com.
authors.forename: Sheik
authors.initials: S
authors.lastname: Aliya
authors.affiliation: Department of Radiation Oncology, Cancer Biology Division, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, United States. Electronic address: rkotipatruni@uchicago.edu.
authors.forename: Rama P
authors.initials: RP
authors.lastname: Kotipatruni
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom. Electronic address: madanraj.appiah@gmail.com.
authors.forename: Appiya Santharam
authors.initials: AS
authors.lastname: Madanraj
authors.affiliation: Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States. Electronic address: alhammo@emory.edu.
authors.forename: Anthea
authors.initials: A
authors.lastname: Hammond
authors.affiliation: Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States. Electronic address: dpark33@emory.edu.
authors.forename: Dongkyoo
authors.initials: D
authors.lastname: Park
authors.affiliation: Office of Regulatory Science, Food and Drug Administration, Rockville, MD 20857, United States. Electronic address: srinivasulu.chigurupati@fda.hhs.gov.
authors.forename: Srinivasulu
authors.initials: S
authors.lastname: Chigurupati
authors.affiliation: Department of Microbiology, Banasthali University, Banasthali, Rajasthan 304022, India. Electronic address: aafroj@banasthali.in.
authors.forename: Afroz
authors.initials: A
authors.lastname: Alam
authors.affiliation: Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India. Electronic address: sp.zool@buodisha.edu.in.
authors.forename: Subasini
authors.initials: S
authors.lastname: Pattnaik
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D063646:Carcinogenesis / Q000378:metabolism*; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism*; D054419:Receptors, Adiponectin / Q000378:metabolism
chemical_list: D052242:Adiponectin; D054419:Receptors, Adiponectin
keywords: Adiponectin; Breast cancer; Cervical cancer; Endometrial cancer; Obesity; Ovarian cancer