title: Mouse models for studies of HLA-G functions in basic science and pre-clinical research.
abstract: HLA-G was described originally as a tolerogenic molecule that allows the semiallogeneic fetus to escape from recognition by the maternal immune response. This review will discuss different steps in the study of HLA-G expression and functions in vivo, starting with analyses of expression of the HLA-G gene and its receptors in transgenic mice, and continuing with applications of HLA-G and its receptors in prevention of allograft rejection, transplantation tolerance, and controlling the development of infection. Humanized mouse models have been discussed for developing in vivo studies of HLA-G in physiological and pathological conditions. Collectively, animal models provide an opportunity to evaluate the importance of the interaction between HLA-G and its receptors in terms of its ability to regulate immune responses during maternal-fetal tolerance, survival of allografts, tumor-escape mechanisms, and development of infections when both HLA-G and its receptors are expressed. In addition, in vivo studies on HLA-G also offer novel approaches to achieve a reproducible transplantation tolerance and to develop personalized medicine to prevent allograft rejection.
authors.affiliation: Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, 1140 Laney Walker Blvd, Augusta, GA 30912, USA.
authors.forename: Anh Thu
authors.initials: AT
authors.lastname: Nguyen-Lefebvre
authors.affiliation: Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, 1140 Laney Walker Blvd, Augusta, GA 30912, USA.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Ajith
authors.affiliation: Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, 1140 Laney Walker Blvd, Augusta, GA 30912, USA.
authors.forename: Vera
authors.initials: V
authors.lastname: Portik-Dobos
authors.affiliation: Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, 1140 Laney Walker Blvd, Augusta, GA 30912, USA.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Horuzsko
authors.affiliation: Department of Medicine, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Mulloy
authors.affiliation: Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, 1140 Laney Walker Blvd, Augusta, GA 30912, USA; Department of Medicine, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA. Electronic address: ahoruzsko@gru.edu.
authors.forename: Anatolij
authors.initials: A
authors.lastname: Horuzsko
mesh_terms: D000818:Animals; D005260:Female; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D059951:HLA-G Antigens / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D007239:Infections / Q000276:immunology* / Q000628:therapy; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D023421:Models, Animal; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D016377:Organ Transplantation; D057285:Precision Medicine; D011247:Pregnancy / Q000276:immunology*; D019139:Tumor Escape
chemical_list: D059951:HLA-G Antigens
keywords: HLA-G; Humanized mice; Transgenic mice; Transplantation