title: Persistence of metabolic syndrome and its impact on glucose metabolism in overweight and obese children and adolescents.
abstract: OBJECTIVE
  To verify the effects of metabolic syndrome (MS) and its relation to insulin resistance (IR) in children and adolescents with overweight or obesity after 24 months of follow-up.
  
  
  METHODS
  Studies of repeated measures from April 2009 to April 2012. For both measurements, the evaluations performed were anthropometry, MS diagnosis, fasting blood glucose, glucose homeostasis model assessment (HOMA-IR), and insulin level; at a second evaluation, glycated hemoglobin (HbA1c) was used as an additional indicator of glucose metabolism alterations. Logistic regression between syndrome persistence and its components with glucose metabolism alterations was performed for each of its indicators. The SPSS version 17.0 software (95% CI) was used.
  
  
  METHODS
  Center for Childhood Obesity, Campina Grande, Brazil.
  
  
  METHODS
  Children and adolescents (n=133), aged 2-18 years, with overweight or obesity.
  
  
  RESULTS
  There was a significant decrease in MS during the study period, with persistence of the syndrome in 17.3% of the individuals. The presence of at least one alteration in glucose metabolism occurred in 45.1% of children and adolescents. The systolic and diastolic blood pressure, and the average levels of HOMA-IR showed significant decrease at the end of 24 months (p<0.01), and an elevated waist circumference (WC) remained associated with IR (p<0.01).
  
  
  CONCLUSIONS
  There was observed no relationship of IR or other indicator of glycemic disorders by persistence of MS. An elevated WC remained associated with IR after controlling for the effects of the following variables: gender, age group, and other MS components.
authors.affiliation: Department of Nursing, Federal University of Paraiba (UFPB).
authors.forename: Anajás
authors.initials: A
authors.lastname: da Silva Cardoso Cantalice
authors.affiliation: International Health at the Institute of Tropical Medicine and Hygiene, Nova University of Lisbon, Portugal.
authors.forename: Inês
authors.initials: I
authors.lastname: Fronteira
authors.affiliation: Department of Nursing and Public Health, School of Ribeirão Preto, São Paulo University.
authors.forename: Jordana
authors.initials: J
authors.lastname: de Almeida Nogueira
authors.affiliation: Department of Health of Children and Adolescents, Federal University of Pernambuco.
authors.forename: Altamira Pereira
authors.initials: AP
authors.lastname: da Silva Reichert
authors.affiliation: Department of Health of Children and Adolescents, State University of Campinas (UNICAMP).
authors.forename: Carla Campos
authors.initials: CC
authors.lastname: Muniz Medeiros
authors.affiliation: Department of Nursing of Public Health and Psychiatry of the Health Sciences Centre (DESPP/CCS).
authors.forename: Neusa
authors.initials: N
authors.lastname: Collet
keywords: adolescent; children; insulin resistance; metabolic syndrome X; obesity