title: Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting.
abstract: Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into "nanomedicine" based on the understanding of Trojan horse-anti-tumor mechanism of inorganic nano-medicines. Moreover, we reported the green and facile synthesis route of mono-dispersed and rod-like zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites. We found that the nanocomposites exhibited high-efficiency killing ability to tumor cells through lipid peroxidation mediated-membrane disintegration route. The safety studies in BALB/c mice didn't detect injection anaphylaxis, hemolysis and cytotoxicity. More interestingly, the nano-composites could specially accumulate in liver and kidney, which will be helpful for targeting cure to these regional cancers.
authors.affiliation: Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.|New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-0845, Japan.
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
authors.forename: Cai-Feng
authors.initials: CF
authors.lastname: Wang
authors.affiliation: Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
authors.forename: Shi-Zhong
authors.initials: SZ
authors.lastname: Cui
authors.affiliation: Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Mi
authors.affiliation: Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.|New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-0845, Japan.
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000008:administration & dosage* / Q000009:adverse effects; D050997:Nanomedicine; D015028:Zein / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism* / Q000493:pharmacokinetics; D015034:Zinc Oxide / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism* / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D015028:Zein; D019256:Cadmium Chloride; D015034:Zinc Oxide