title: Association of DNA repair gene polymorphisms with response to cisplatin-based concurrent chemoradiotherapy in patients with cervical carcinoma.
abstract: The aim of this study was to investigate polymorphisms in DNA repair genes as potential predictive factors among Chinese cervical cancer patients.
  
  
  
  A total of 72 patients with cervical carcinoma, who received cisplatin-based chemoradiotherapy and whose responses were evaluated by Response Evaluation Criteria in Solid Tumors, were included. The association between response to chemoradiotherapy and the genotypes for 29 single-nucleotide polymorphisms (SNPs) in 25 DNA repair genes were analyzed.
  
  
  
  A minor allele of SNP rs9350 in the exonuclease 1 gene was associated with a better response rate, regardless of age and tumor stage (odds ratio, 8.316; p=0.002).
  
  
  
  SNP rs9350 in the exonuclease 1 gene is involved in inter-individual differences in the response to cisplatin-based chemoradiotherapy, in patients with cervical carcinoma.
authors.affiliation: The National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, PR China.
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Liu
authors.affiliation: The National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, PR China.
authors.forename: Pei
authors.initials: P
authors.lastname: Xi
authors.affiliation: Department of Radiotherapy Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
authors.forename: Yan-Lan
authors.initials: YL
authors.lastname: Chai
authors.affiliation: Department of Radiotherapy Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China. Electronic address: liuzmail@163.com.
authors.forename: Zi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: The National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, PR China. Electronic address: daipg@nwu.edu.cn.
authors.forename: Peng-Gao
authors.initials: PG
authors.lastname: Dai
mesh_terms: D059248:Chemoradiotherapy; D002945:Cisplatin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology / Q000628:therapy
chemical_list: D002945:Cisplatin
keywords: Cervical carcinoma; Chemoradiotherapy; Exonuclease 1; Polymorphisms; Response