title: The Mechanism of Metabolic Surgery: Gastric Center Hypothesis.
abstract: There is growing evidence that bariatric surgery can lead to remission of metabolic syndrome. But the mechanism by which bariatric surgery alleviates metabolic syndrome is unclear.
  
  
  
  Several present hypotheses which include decreased caloric intake following the surgeries, foregut and hindgut hypothesis, bile acid and bacterial flora changes, and proposed gastric center hypothesis were discussed.
  
  
  
  None of the currently available hypotheses is solely capable to lead to a reasonable explanation regarding improvement of metabolic syndrome by various bariatric surgical procedures. Proposed gastric center hypothesis could give a better explanation of the mechanism.
  
  
  
  All the present bariatric surgeries are involved in changes of the stomach. There could be some particular cells on the stomach, which could secrete unknown special hormones, and then lead to control the metabolic process.
authors.affiliation: Chief of Bariatric and Metabolic Surgery, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Pudong, Shanghai, China. zhujiangfan@hotmail.com.
authors.forename: Jiangfan
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Bariatric and Metabolic Surgery, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Pudong, Shanghai, China.
authors.forename: Radheshyam
authors.initials: R
authors.lastname: Gupta
authors.affiliation: East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Pudong, Shanghai, China.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Safwa
mesh_terms: D050110:Bariatric Surgery / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D006801:Humans; D024821:Metabolic Syndrome / Q000601:surgery*; D009767:Obesity, Morbid / Q000601:surgery*; D016896:Treatment Outcome; D015431:Weight Loss
keywords: Bariatric surgery; Gastric center hypothesis; Metabolic syndrome; Obesity