title: The efficacy and safety of clotrimazole vaginal tablet vs. oral fluconazole in treating severe vulvovaginal candidiasis.
abstract: To compare the efficacy and safety of two doses of clotrimazole vaginal tablet 500 mg with two doses of oral fluconazole 150 mg in treating severe vulvovaginal candidiasis (SVVC), 240 consecutive patients with SVVC were studied at the Department of Obstetrics and Gynaecology of Peking University Shenzhen Hospital between June 2014, and September 2015. Patients were randomly assigned in a 1 : 1 ratio to receive treatment with either two doses of clotrimazole vaginal tablet or two doses of oral fluconazole. The clinical cure rates in the clotrimazole group and the fluconazole group at days 7-14 follow-up were 88.7% (102/115) and 89.1% (98/110) respectively; the clinical cure rates at days 30-35 in the two groups were 71.9% (82/114) and 78.0% (85/109) respectively. The mycological cure rates at days 7-14 follow-up in the two groups were 78.3% (90/115) and 73.6% (81/110) respectively. The mycological cure rates of the patients at days 30-35 in the two groups were 54.4% (62/114) and 56.0% (61/109) respectively (P > 0.05). The adverse events of clotrimazole were mainly local. This study demonstrated that two doses of clotrimazole vaginal tablet 500 mg were as effective as two doses of oral fluconazole 150 mg in the treatment of patients with SVVC and could be an appropriate treatment for this disorder.
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University Shenzhen Hospital, Shenzhen, China.|Postgraduate College, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University Shenzhen Hospital, Shenzhen, China.|Postgraduate College, Anhui Medical University, Hefei, Anhui, China.|Shenzhen Key Laboratory of Gynaecological Diagnostic Technology Research, Shenzhen, China.
authors.forename: Shangrong
authors.initials: S
authors.lastname: Fan
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Laboratory Science, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: Yiheng
authors.initials: Y
authors.lastname: Liang
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002175:Candida / Q000145:classification / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D003022:Clotrimazole / Q000009:adverse effects; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D013607:Tablets; D016896:Treatment Outcome; D014621:Vagina / Q000382:microbiology; D014622:Vaginal Creams, Foams, and Jellies; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D013607:Tablets; D014622:Vaginal Creams, Foams, and Jellies; D015725:Fluconazole; D003022:Clotrimazole
keywords: Vulvovaginal candidiasis; antifungal susceptibility; clotrimazole; fluconazole