title: Swept-Source Optical Coherence Tomography and OCT Angiography of Minocycline-Induced Retinal and Systemic Hyperpigmentation.
abstract: This is a report of an 80-year-old man with a history of rosacea and rhinophyma treated for 15 years with oral minocycline who developed significant minocycline-induced hyperpigmentation. He also had a history of Fuchs' endothelial dystrophy and had undergone penetrating keratoplasty in the right eye. Best-corrected visual acuity was 20/60 in both eyes. Examination revealed slate-grey hyperpigmentation of his body, face, and sclera and black, confluent pigmentation in the central maculae of both eyes. Green wavelength fundus autofluorescence demonstrated speckled hyperautofluorescence in the right eye, and swept-source OCT and OCTA demonstrated pigmented epithelial detachments and significant signal blocking without choroidal neovascularization.
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Jung
authors.forename: Michael H
authors.initials: MH
authors.lastname: Chen
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Sorenson
authors.forename: Soraya
authors.initials: S
authors.lastname: Rofagha
mesh_terms: D000284:Administration, Oral; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005451:Fluorescein Angiography; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000000981:diagnostic imaging*; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D064847:Multimodal Imaging; D061848:Optical Imaging; D011446:Prospective Studies; D012163:Retinal Detachment / Q000139:chemically induced / Q000000981:diagnostic imaging*; D055213:Retinal Pigment Epithelium / Q000187:drug effects / Q000473:pathology*; D012224:Rhinophyma / Q000188:drug therapy; D012393:Rosacea / Q000188:drug therapy; D041623:Tomography, Optical Coherence
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline