title: Anabolic hormone profiles in elite military men.
abstract: We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in this population. Overall, the men in this study displayed anabolic hormone profiles comparable to that of healthy, athletic populations. Consistent with the cortisol findings in our prior report, summary parameters of magnitude (hormone output) within the first hour after awakening displayed superior stability versus summary parameters of pattern for both DHEA (r range: 0.77-0.82) and testosterone (r range: 0.62-0.69). Summary parameters of evening function were stable for the two hormones (both p<0.001), while the absolute decrease in testosterone across the day was a stable proxy of diurnal function (p<0.001). Removal of noncompliant subjects did not appreciably affect concentration estimates for either hormone at any time point, nor did it alter the repeatability of any summary parameter. The first of its kind, this report enables accurate estimations of anabolic balance and resultant effects upon health and human performance in this highly resilient yet chronically stressed population.
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, United States; Department of Exercise and Nutritional Sciences, San Diego State University, ENS Building, Room 351, 5500 Campanile Drive, San Diego, CA 92182, United States; Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, 550 E. Orange Street, Tempe, AZ 85287, United States. Electronic address: marcus.k.taylor2.civ@mail.mil.
authors.forename: Marcus K
authors.initials: MK
authors.lastname: Taylor
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, United States.
authors.forename: Shiloah A
authors.initials: SA
authors.lastname: Kviatkovsky
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, United States; Department of Exercise and Nutritional Sciences, San Diego State University, ENS Building, Room 351, 5500 Campanile Drive, San Diego, CA 92182, United States.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Hernández
authors.affiliation: Naval Special Warfare Group ONE, 3632 Guadalcanal Road, Building 165, San Diego, CA 92155, United States.
authors.forename: Paul
authors.initials: P
authors.lastname: Sargent
authors.affiliation: Department of Psychology, Arizona State University, 550 E. Orange Street, Tempe, AZ 85287, United States.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Segal
authors.affiliation: Johns Hopkins School of Nursing and Bloomberg School of Public Health, 3400 North Charles Street, Baltimore, MD 21218, United States; Institute for Interdisciplinary Salivary Bioscience, University of California - Irvine, Irvine, CA 92697, United States; Salivary Bioscience Laboratory and Department of Psychology, University of Nebraska, 1400 R. Street, Lincoln, NE, United States.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Granger
mesh_terms: D000328:Adult; D003687:Dehydroepiandrosterone / Q000032:analysis*; D019314:Dehydroepiandrosterone Sulfate / Q000032:analysis*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D008297:Male; D008889:Military Personnel; D012463:Saliva / Q000737:chemistry*; D013739:Testosterone / Q000032:analysis*
chemical_list: D013739:Testosterone; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone
keywords: Anabolic; Dehydroepiandrosterone; Military; Special operations; Stress; Testosterone