title: [Pathophysiology of Acute Kidney Injury in sepsis].
abstract: Sepsis is a serious medical condition often complicated by multiorgan failure, especially in the intensive care unit setting. Acute renal failure is a frequent complication of sepsis, leading to increased hospital mortality risk and worsening of patient outcome. Despite recent advances in the treatment of sepsis and acute renal failure, the pathophysiological mechanisms of acute renal failure in sepsis is still not fully ascertained. The aim of this review is to illustrate the pathophysiological mechanisms that are involved in the development of acute renal failure in sepsis, with special regard to the systemic hemodynamic alterations, renal microvascular and inflammatory/immunological mechanisms.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Antoniotti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Regolisti
authors.forename: Paolo
authors.initials: P
authors.lastname: Greco
authors.forename: Filippo
authors.initials: F
authors.lastname: Fani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Castellano
authors.forename: Loreto
authors.initials: L
authors.lastname: Gesualdo
authors.forename: Umberto
authors.initials: U
authors.lastname: Maggiore
authors.forename: Enrico
authors.initials: E
authors.lastname: Fiaccadori
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D007362:Intensive Care Units; D009102:Multiple Organ Failure / Q000503:physiopathology; D012307:Risk Factors; D018805:Sepsis / Q000150:complications / Q000401:mortality / Q000503:physiopathology*