title: Association study of GABA system genes polymorphisms with amphetamine-induced psychotic disorder in a Han Chinese population.
abstract: GABA system genes have been implicated in neurotrophy and neurogenesis, which play pivotal roles in an individual's variation in vulnerability to amphetamine addiction or amphetamine-induced psychosis (AIP). We hypothesized that common genetic variants in the GABA system genes may be associated with amphetamine-induced psychotic disorder. In our study, thirty-six single nucleotide polymorphisms (SNPs) within the GABA system genes were genotyped in 400 amphetamine-induced psychotic disorder patients and 400 amphetamine use disorders patients (AUP) (not including those categorized as psychosis) in the Han Chinese population. In this study, 51.88% of the Han Chinese amphetamine-type substance use disorder patients met the criteria of amphetamine-induced psychotic disorder, and 79.5% amphetamine-induced psychotic disorder patients had auditory hallucinations, while 46.5% had delusions of reference. The allele frequency of rs1129647 showed nominal association with AIP in the Han Chinese population (P=0.03). Compared with AUP group patients, T allele frequency of AIP group patients was significantly increased. The adjustment for age and gender factors in the AIP and AUP patients was executed using unconditional logistic regression under five inheritance models. The genotype frequency of rs1129647 showed nominal association with AIP in the log-additive model (P=0.04). The genotype frequency of rs2290733 showed nominal association with AIP in the recessive model (P=0.04). Compared with female AIP patients, male patients were more likely to have the CC genotype of rs17545383 (P=0.04). Moreover, we determined that more male patients carried the T allele of rs2290733 in the AIP group (P=0.004). Unfortunately, the significant differences did not survive Benjamini-Hochberg false discovery rate correction (adjusted P>0.05). No association between the SNPs of the GABA system genes and amphetamine-induced psychotic disorder risk was identified. No haplotype of the GABA system genes affected amphetamine-induced psychotic disorder risk. This report describes the first association study between the GABA system genes and amphetamine-induced psychotic disorder in the Han Chinese population. Our data may provide a reference for future research.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China; Wuxi Mental Health Center, Nanjing Medical University, 214151, Wuxi, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.
authors.forename: Qingzhong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China. Electronic address: yushuny@yahoo.com.
authors.forename: Shunying
authors.initials: S
authors.lastname: Yu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China. Electronic address: drminzhao@gmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000009:adverse effects*; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000208:ethnology / Q000235:genetics*; D011963:Receptors, GABA-A / Q000235:genetics; D012306:Risk; D005680:gamma-Aminobutyric Acid / Q000235:genetics*
chemical_list: C546240:GABRA1 protein, human; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D000661:Amphetamine
keywords: Amphetamine-induced psychotic disorder; GABA; Polymorphisms