title: Hyoid bone displacement as parameter for swallowing impairment in patients treated for advanced head and neck cancer.
abstract: Reduced hyoid displacement is thought to contribute to aspiration and pharyngeal residues in head and neck cancer (HNC) patients with dysphagia. To further study hyoid elevation and anterior excursion in HNC patients, this study reports on temporal/kinematic measures of hyoid displacement, with the additional goal to investigate correlations with clinical swallowing impairment. A single-blind analysis of data collected as part of a larger prospective study was performed at three time points before and after chemoradiotherapy. Twenty-five patients had undergone clinical swallowing assessments at baseline, 10-weeks, and 1-year post-treatment. Analysis of videofluoroscopic studies was done on different swallowing consistencies of varying amounts. The studies were independently reviewed frame-by-frame by two clinicians to assess temporal (onset and duration) and kinematic (anterior/superior movement) measures of hyoid displacement (ImageJ), laryngeal penetration/aspiration, and presence of vallecula/pyriform sinus residues. Patient-reported oral intake and swallowing function were also evaluated. Mean maximum hyoid displacement ranged from 9.4 mm (23 % of C2-4 distance) to 12.6 mm (27 %) anteriorly, and from 18.9 mm (41 %) to 24.9 mm (54 %) superiorly, depending on bolus volume and consistency. Patients with reduced superior hyoid displacement perceived significantly more swallowing impairment. No correlation between delayed or reduced hyoid excursion and aspiration or residue scores could be demonstrated. Hyoid displacement is subject to variability from a number of sources. Based on the results, this parameter seems not very valuable for clinical use in HNC patients with dysphagia.
authors.affiliation: Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
authors.forename: Sophie A C
authors.initials: SA
authors.lastname: Kraaijenga
authors.affiliation: Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
authors.forename: Lisette
authors.initials: L
authors.lastname: van der Molen
authors.affiliation: Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.|Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors.forename: Wilma D
authors.initials: WD
authors.lastname: Heemsbergen
authors.affiliation: Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
authors.forename: Gawein B
authors.initials: GB
authors.lastname: Remmerswaal
authors.affiliation: Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.|Institute of Phonetic Sciences, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Frans J M
authors.initials: FJ
authors.lastname: Hilgers
authors.affiliation: Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. m.vd.brekel@nki.nl.|Institute of Phonetic Sciences, University of Amsterdam, Amsterdam, The Netherlands. m.vd.brekel@nki.nl.|Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, The Netherlands. m.vd.brekel@nki.nl.
authors.forename: Michiel W M
authors.initials: MW
authors.lastname: van den Brekel
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000628:therapy; D059248:Chemoradiotherapy; D003679:Deglutition / Q000502:physiology*; D003680:Deglutition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005471:Fluoroscopy; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000628:therapy; D006801:Humans; D006928:Hyoid Bone / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016037:Single-Blind Method; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Aspiration; Chemoradiotherapy; Displacement; Dysphagia; Elevation; Head and neck neoplasms; Hyoid bone; Kinematics