title: Polymorphisms in tumor necrosis factor-alpha (-863C>A, -857C>T and +488G>A) are associated with idiopathic recurrent pregnancy loss in Korean women.
abstract: Polymorphisms in TNF-a have been reported as genetic risk factors for recurrent spontaneous abortion and TNF-α may be immunologically important. We therefore examined the contribution of several TNF-a mutations to this phenomenon. The study participants consisted of 388 patients with idiopathic recurrent pregnancy loss (RPL), which was diagnosed on the basis of at least two consecutive spontaneous abortions; control subjects were 224 healthy women with a history of successful pregnancies. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to determine the TNF-α -863C>A, -857C>T, and +488G>A genotypes. The TNF-α -863C>A variants correlated with increased risk of RPL (CA+AA; adjusted odds ratio [AOR], 2.142; 95% confidence interval [CI], 1.493-3.074). These data did not differ in a stratified analysis according to number of consecutive spontaneous abortions. In haplotype analysis, there were similar trends of data for combination analysis, but in patients with 3+ pregnancy losses, a stratified analysis revealed that this correlation did not increase directly with the number of pregnancy losses. The TNF-α -863C>A variant is a possible genetic risk factor for idiopathic RPL in Korean women.
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 13496, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, South Korea.
authors.forename: Hyo Geun
authors.initials: HG
authors.lastname: Jang
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, South Korea.
authors.forename: Youngsok
authors.initials: Y
authors.lastname: Choi
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 13496, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, South Korea.
authors.forename: Jung Oh
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 13496, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, South Korea.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 13496, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, South Korea.
authors.forename: HyungChul
authors.initials: H
authors.lastname: Rah
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 13496, South Korea.
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Cho
authors.affiliation: Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam 13496, South Korea.
authors.forename: Ji Hyang
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul 135-081, South Korea. Electronic address: wooslee@cha.ac.kr.
authors.forename: Woo Sik
authors.initials: WS
authors.lastname: Lee
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 13496, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, South Korea. Electronic address: nkkim@cha.ac.kr.
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Genetics association; Polymorphism; Recurrent pregnancy loss; Risk factor; Tumor necrosis factor