title: Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates.
abstract: To estimate the prevalence of juvenile onset recurrent respiratory papillomatosis (RRP) in Australia, describe its epidemiological profile, and assess the positive predictive value of International Classification of Disease, 10th revision (ICD-10) code D14.1 (benign neoplasm of larynx) in children for hospitalization due to RRP.
  
  
  
  Retrospective case series.
  
  
  
  Retrospective case review undertaken at the three tertiary pediatric hospitals in New South Wales (Australia's largest state), by reviewing medical records of patients aged 0 to 16 years admitted during 2000-2009 containing the ICD-10 Australian modification code D14.1 or other possible disease (D14.2-4, D14.3, D14.4) and RRP-related procedure codes. For RRP diagnoses, we recorded treatment dates, length of stay, extent of disease, and surgical and adjuvant treatments. The positive predictive value (PPV) of code D14.1 and median number of hospitalizations per year were applied to national hospital separations data from 2000/2001 to 2012/2013 to estimate disease prevalence.
  
  
  
  We identified 30 cases of RRP using code D14.1, which had a PPV of 98.1%, with no further cases identified using other codes. Fifty-seven percent of cases were female, median age of onset was 36 months, and median treatment duration was 36 months (mean = 40 months, range = 1-118). There was one patient death. Between 2000 and 2013, the estimated national prevalence rate was 0.81 per 100,000 aged < 15 years, peaking at age 5 to 9 years (1.1 per 100,000).
  
  
  
  RRP prevalence can be monitored after human papillomavirus vaccination programs using routine hospital data.
  
  
  
  4 Laryngoscope, 126:2827-2832, 2016.
authors.affiliation: University of Sydney Medical School, Canterbury Hospital, St. Leonards, New South Wales, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Novakovic
authors.affiliation: Department of Paediatric Otolaryngology, Children's Hospital at Westmead, University of Sydney, Westmead, New South Wales, Australia.
authors.forename: Alan T L
authors.initials: AT
authors.lastname: Cheng
authors.affiliation: Wellington Hospital, Wellington, New Zealand.
authors.forename: Katherine
authors.initials: K
authors.lastname: Baguley
authors.affiliation: Departments of Surgery and Paediatrics, University of Newcastle, New Lambton, New South Wales, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Walker
authors.affiliation: Head, Ear, Nose, and Throat Department, Sydney Children's Hospital, Randwick, New South Wales, Australia.
authors.forename: Henley
authors.initials: H
authors.lastname: Harrison
authors.affiliation: Head, Ear, Nose, and Throat Department, Sydney Children's Hospital, Randwick, New South Wales, Australia.
authors.forename: Marlene
authors.initials: M
authors.lastname: Soma
authors.affiliation: National HPV Vaccination Program Register, East Melbourne, Victoria, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Malloy
authors.affiliation: National HPV Vaccination Program Register, East Melbourne, Victoria, Australia.|School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Julia M L
authors.initials: JM
authors.lastname: Brotherton
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D017668:Age of Onset; D001315:Australia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D054869:Clinical Audit; D005260:Female; D006753:Hospital Records; D006760:Hospitalization; D006776:Hospitals, Pediatric; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D006801:Humans; D007223:Infant; D038801:International Classification of Diseases; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies
chemical_list: D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
keywords: Recurrent respiratory papillomatosis; human papillomavirus; immunization; larynx; papillomatosis