title: Prevention of adhesion bands by ibuprofen-loaded PLGA nanofibers.
abstract: In this study, prevention of the adhesion bands and inflammatory features has been investigated using poly (lactic-co-glycolic acid)-ibuprofen (PLGA-IB) nanofibrous meshes in a mice model. To find the optimized membrane for prevention of postoperative adhesion bands, we have compared PLGA-IB group with PLGA, IB, and control groups in a mice adhesion model. Two scoring adhesion systems were used to represent the outcome. According to the results obtained in this study, the PLGA-IB nanofiber membrane showed a greater reduction in adhesion band than other groups. In conclusion, among FDA-approved polymers and drugs, PLGA-IB meshes could be applicable as a potential candidate for prevention of postoperative abdominal inflammation and adhesion bands formation. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:990-997, 2016.
authors.affiliation: Dept. of Molecular Medicine, School of Medicine, Qazvin University of Medical Science, Qazvin, Iran.|Dept. of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Jamshidi-Adegani
authors.affiliation: Dept. of Biotechnology, College of Science, University of Tehran, Tehran, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Seyedjafari
authors.affiliation: Dept. of Physiology and Medical Physics, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Nematollah
authors.initials: N
authors.lastname: Gheibi
authors.affiliation: Dept. of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, Tehran, Iran.|Dept. of Hematology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Soleimani
authors.affiliation: Dept. of Clinical Biochemistry and Genetics, Cellular and Molecular Research Center, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sahmani
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology*; D019344:Lactic Acid / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D057139:Nanofibers / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry / Q000494:pharmacology*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D007052:Ibuprofen
keywords: ibuprofen; intraperitoneal adhesion; poly(lactic-co-glycolic acid)