title: Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman.
abstract: We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Bryan
authors.initials: B
authors.lastname: Steussy
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Lekostaj
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Qining
authors.initials: Q
authors.lastname: Qian
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Nancy
authors.initials: N
authors.lastname: Rosenthal
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Holman
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Sergei
authors.initials: S
authors.lastname: Syrbu
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Darbro
authors.affiliation: Department of Pathology, University of Iowa, Iowa City.
authors.forename: Aaron
authors.initials: A
authors.lastname: Bossler
authors.affiliation: Department of Pathology, University of Iowa, Iowa City nitin-karandikar@uiowa.edu.
authors.forename: Nitin J
authors.initials: NJ
authors.lastname: Karandikar
mesh_terms: D044503:5-Methylcytosine; D001402:B-Lymphocytes / Q000502:physiology*; D019070:Cell Lineage; D054338:Cell Transdifferentiation; D002999:Clone Cells; D005260:Female; D006644:Histiocytes / Q000502:physiology*; D006801:Humans; D059785:Karyotype; D007948:Leukemia, Monocytic, Acute / Q000175:diagnosis* / Q000235:genetics; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000235:genetics; D008875:Middle Aged
chemical_list: D044503:5-Methylcytosine
keywords: B cell; histiocytic; leukemia; lymphoma; sarcoma; transdifferentiation