title: Significant improvement in crow's feet after treatment with Jet-M and a mixed solution of copper-GHK, oligo-hyaluronic acid, rhodiolar extract, tranexamic acid, and β-glucan (GHR formulation).
abstract: Jet-M (Tav-Tech Ltd., Israel) is an instrument for skin resurfacing. When it sprays microdroplets of solution or shoots air on the skin, exfoliation and stretching of superficial layers can occur. Thus, it will increase percutaneous absorption of vitamins and other cosmetic agents. A cosmetic preparation containing copper-glycyl-L-histidyl-L-lysine, oligo-hyaluronic acid, rhodiolar extract, tranexamic acid, and β-glucan was used with Jet-M in one patient. Anesthesia was not administered and there was no pain during the treatment. A male aged 59 years was treated once a week for 12 weeks. In the clinical photographs, wrinkles around the treated eye were greatly decreased. Skin biopsies were taken from treated and untreated areas. Hematoxylin and eosin and Masson's trichrome staining showed increased collagen production in the upper dermis. On the other hand, collagen IV production was slightly increased. Fibrillin-1 and procollagen type 1 were greatly increased and tropoelastin was also increased. There was no adverse effect during and after treatment.
authors.forename: Sang-Young
authors.initials: SY
authors.lastname: Byun
authors.affiliation: a Department of Dermatology , Seoul National University College of Medicine and Seoul National University Bundang Hospital , Seongnam , Korea.
authors.forename: Je-Byeong
authors.initials: JB
authors.lastname: Chae
authors.affiliation: a Department of Dermatology , Seoul National University College of Medicine and Seoul National University Bundang Hospital , Seongnam , Korea.
authors.forename: Jung-Im
authors.initials: JI
authors.lastname: Na
authors.affiliation: a Department of Dermatology , Seoul National University College of Medicine and Seoul National University Bundang Hospital , Seongnam , Korea.
authors.forename: Kyoung-Chan
authors.initials: KC
authors.lastname: Park
mesh_terms: D003094:Collagen / Q000378:metabolism; D003358:Cosmetics / Q000627:therapeutic use*; D005145:Face; D006801:Humans; D006820:Hyaluronic Acid; D008239:Lysine; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides; D009942:Organometallic Compounds; D029771:Rhodiola; D015595:Skin Aging / Q000187:drug effects*; D014148:Tranexamic Acid; D047071:beta-Glucans
chemical_list: D003358:Cosmetics; D009842:Oligopeptides; D009942:Organometallic Compounds; D047071:beta-Glucans; C053976:copper-lysine complex; C098469:copper-glycyl-glycyl-histidine; D014148:Tranexamic Acid; D006820:Hyaluronic Acid; D003094:Collagen; D008239:Lysine
keywords: Jet-M; crow's feet; laser; skin resurfacing; wrinkles