title: Bone Mineral Density in Adolescent Girls with Hypogonadotropic and Hypergonadotropic Hypogonadism.
abstract: OBJECTIVE
  Deficiency of sex steroids has a negative impact on bone mineral content. In studies conducted on postmenopausal women and animal studies, elevated follicle-stimulating hormone (FSH) levels were found to be correlated with a decrease in bone mineralization and osteoporosis. The aim of the present study was to evaluate bone mineral density (BMD) in adolescent girls with hypogonadotropic and hypergonadotropic hypogonadism and also to investigate the correlation between FSH level and BMD.
  
  
  METHODS
  The study group included 33 adolescent girls with hypogonadism (14 with hypogonadotropic hypogonadism and 19 with hypergonadotropic hypogonadism). FSH, luteinizing hormone, estradiol levels, and BMD (using dual energy x-ray absorptiometry) were measured.
  
  
  RESULTS
  There were no statistically significant differences between the chronological age and bone age of the two patient groups, namely, with hypogonadotropic and hypergonadotropic hypogonadism. There was also no significant difference between BMD z-score values obtained from measurements from the spine and the femur neck of patients in the two groups (p-values were 0.841 and 0.281, respectively). In the hypergonadotropic group, a moderately negative correlation was detected between FSH level and BMD z-score measured from the femur neck (ρ=-0.69, p=0.001), whilst no correlation was observed between FSH levels and height adjusted BMD-z scores measured from the spine (ρ=0.17, p=0.493). FSH level was not found to be an independent variable affecting BMD z-score.
  
  
  CONCLUSIONS
  BMD z-scores were detected to be similar in adolescent girls with hypogonadotropic and hypergonadotropic hypogonadism, and FSH levels were not found to have a clinically relevant impact on BMD.
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Özbek
authors.affiliation: Diyarbakır Children State Hospital, Clinic of Pediatric Endocrinology, Diyarbakır, Turkey; Present position: Hacettepe University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey, Phone: +90 543 370 54 91 E-mail: dr_huseyin@hotmail.com.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Demirbilek
authors.forename: Rıza Taner
authors.initials: RT
authors.lastname: Baran
authors.forename: Ahmet
authors.initials: A
authors.lastname: Baran
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D015519:Bone Density; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000000981:diagnostic imaging*
chemical_list: D005640:Follicle Stimulating Hormone