title: Prognostic significance of overexpressed p16(INK4A) in esophageal squamous cell carcinoma: a meta-analysis.
abstract: The prognostic value of p16(INK4A) in esophageal squamous cell carcinoma (ESCC) has been evaluated for several years although the results remain controversial.
  
  
  
  Various databases were systematically searched to identify studies published on the p16(INK4A) survival rate of ESCC patients. The pooled risk ratios and odds ratios with their corresponding 95% CIs were used to estimate the effect sizes.
  
  
  
  A total of 16 studies comprising 1314 patients were included. p16(INK4A) overexpression was significantly associated with improved 5-year overall survival, disease-free survival, early tumor TNM stages, better tumor histological grade, no lymph node metastasis and more shallow tumor invasive depth (p < 0.05).
  
  
  
  p16(INK4A) expression could be a useful biomarker to predict better prognosis for ESCC patients.
authors.affiliation: Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Lianghai
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Pang
authors.affiliation: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Shugang
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Immunology, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.|Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D016208:Databases, Factual; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16
keywords: esophageal squamous cell carcinoma; meta-analysis; p16INK4A expression; prognosis