title: IL-23/IL-17 axis in spondyloarthritis-bench to bedside.
abstract: Cytokines play a critical role in the pathogenesis of psoriatic arthritis, ankylosing spondylitis, and other types of spondyloarthritis (SpA). Besides IFN-γ and TNF-α; IL-23/IL-17 cytokines play a dominant role in the inflammatory and proliferative cascades of SpA. Recently, in a series of elegant experiments using mouse models and human tissues, it has been demonstrated that IL-23-induced Th17 cytokines (IL-17 and IL-22) can contribute to following pathologic events associated with SpA: development of psoriatic plaque, pannus formation in the joint, joint erosion, and new bone formation. In this review article, we have discussed the contributing role of the IL-23/IL-17 cytokine axis in the pathogenesis of PsA and AS. IL-23/IL-17-targeted therapies are very promising for SpA, and we have provided an outline about usefulness of these new groups of biologics in SpA.
authors.affiliation: Internal Medicine/Rheumatology, VA Medical Center Sacramento, Mather, CA, USA. raysiba@hotmail.com.|School of Medicine, University of California Davis, Davis, CA, USA. raysiba@hotmail.com.|VA Medical Center Sacramento, Division of Rheumatology, Allergy & Clinical Immunology, Davis School of Medicine, University of California, 10535 Hospital Way, Bldg#807, Mather, CA, 95655, USA. raysiba@hotmail.com.
authors.forename: Siba P
authors.initials: SP
authors.lastname: Raychaudhuri
authors.affiliation: Internal Medicine/Rheumatology, VA Medical Center Sacramento, Mather, CA, USA.|School of Medicine, University of California Davis, Davis, CA, USA.
authors.forename: Smriti K
authors.initials: SK
authors.lastname: Raychaudhuri
mesh_terms: D000818:Animals; D015535:Arthritis, Psoriatic / Q000473:pathology; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D053759:Interleukin-23 / Q000276:immunology*; D051379:Mice; D013167:Spondylitis, Ankylosing / Q000276:immunology* / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23
keywords: Ankylosing spoindylitis; IL-17; IL-23; Psoriatic arthritis; Spondyloarthritis; Th17 Cell