title: Scheimpflug lens densitometry and ocular wavefront aberrations in patients with mild nuclear cataract.
abstract: OBJECTIVE
  To test correlations between Scheimpflug optical densitometry and ocular higher-order aberrations (HOAs) in patients with mild nuclear cataract.
  
  
  METHODS
  Cornea and Refractive Surgery Department, Hospital de Braga, Braga, Portugal.
  
  
  METHODS
  Retrospective single-center study.
  
  
  METHODS
  In eyes with mild nuclear cataract, lens densitometry was evaluated by Scheimpflug imaging (Pentacam HR), which provided an objective quantification (mean density and maximum density) and grading (nuclear staging score) of the crystalline lens. A visual function analyzer that combines ray-tracing aberrometry and Placido disk-based topography (iTrace) was used to evaluate the total ocular and internal HOAs.
  
  
  RESULTS
  The study comprised 40 eyes of 30 patients. The mean density of the lens nucleus was 8.99% ± 0.76% (SD) (range 7.5% to 10.8%), and the mean maximum density was 27.96% ± 6.97% (range 16.9% to 56.1%). Regarding the score of nuclear staging of the Scheimpflug device, 28 eyes had level 0 and 12 eyes had level 1. Significant positive correlations were found between the mean density and maximum density parameters and the internal HOAs (ρ = 0.661, P < .001 and ρ = 0.570, P < .001, respectively).
  
  
  CONCLUSIONS
  There were significant correlations between the quantification parameters derived from Scheimpflug lens densitometry and ocular HOAs. The integration of these technologies can help in clinical decision making and in understanding the subjective symptoms of patients with mild nuclear cataracts.
  
  
  BACKGROUND
  Dr. Ambrósio is a consultant to Oculus Optikgeräte GmbH, Alcon Surgical, Inc., and Carl Zeiss Meditec AG. None of the other authors has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Cornea and Refractive Surgery Department (Faria-Correia, Monteiro, Franqueira), Hospital de Braga, and the Life and Health Sciences Research Institute (ICVS) (Faria-Correia, Monteiro), School of Health Sciences, University of Minho, Braga, and the ICVS/3B's-PT Government Associate Laboratory (Faria-Correia), Braga/Guimarães, Portugal; the Rio de Janeiro Corneal Tomography and Biomechanics Study Group (Faria-Correia, Lopes, Ambrósio), Instituto de Olhos Renato Ambrósio (Lopes, Ambrósio), and VisareRio (Ambrósio), Rio de Janeiro, and the Federal University of São Paulo (Ambrósio), São Paulo, Brazil. Electronic address: f.faria.correia@gmail.com.
authors.forename: Fernando
authors.initials: F
authors.lastname: Faria-Correia
authors.affiliation: From the Cornea and Refractive Surgery Department (Faria-Correia, Monteiro, Franqueira), Hospital de Braga, and the Life and Health Sciences Research Institute (ICVS) (Faria-Correia, Monteiro), School of Health Sciences, University of Minho, Braga, and the ICVS/3B's-PT Government Associate Laboratory (Faria-Correia), Braga/Guimarães, Portugal; the Rio de Janeiro Corneal Tomography and Biomechanics Study Group (Faria-Correia, Lopes, Ambrósio), Instituto de Olhos Renato Ambrósio (Lopes, Ambrósio), and VisareRio (Ambrósio), Rio de Janeiro, and the Federal University of São Paulo (Ambrósio), São Paulo, Brazil.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Lopes
authors.affiliation: From the Cornea and Refractive Surgery Department (Faria-Correia, Monteiro, Franqueira), Hospital de Braga, and the Life and Health Sciences Research Institute (ICVS) (Faria-Correia, Monteiro), School of Health Sciences, University of Minho, Braga, and the ICVS/3B's-PT Government Associate Laboratory (Faria-Correia), Braga/Guimarães, Portugal; the Rio de Janeiro Corneal Tomography and Biomechanics Study Group (Faria-Correia, Lopes, Ambrósio), Instituto de Olhos Renato Ambrósio (Lopes, Ambrósio), and VisareRio (Ambrósio), Rio de Janeiro, and the Federal University of São Paulo (Ambrósio), São Paulo, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Monteiro
authors.affiliation: From the Cornea and Refractive Surgery Department (Faria-Correia, Monteiro, Franqueira), Hospital de Braga, and the Life and Health Sciences Research Institute (ICVS) (Faria-Correia, Monteiro), School of Health Sciences, University of Minho, Braga, and the ICVS/3B's-PT Government Associate Laboratory (Faria-Correia), Braga/Guimarães, Portugal; the Rio de Janeiro Corneal Tomography and Biomechanics Study Group (Faria-Correia, Lopes, Ambrósio), Instituto de Olhos Renato Ambrósio (Lopes, Ambrósio), and VisareRio (Ambrósio), Rio de Janeiro, and the Federal University of São Paulo (Ambrósio), São Paulo, Brazil.
authors.forename: Nuno
authors.initials: N
authors.lastname: Franqueira
authors.affiliation: From the Cornea and Refractive Surgery Department (Faria-Correia, Monteiro, Franqueira), Hospital de Braga, and the Life and Health Sciences Research Institute (ICVS) (Faria-Correia, Monteiro), School of Health Sciences, University of Minho, Braga, and the ICVS/3B's-PT Government Associate Laboratory (Faria-Correia), Braga/Guimarães, Portugal; the Rio de Janeiro Corneal Tomography and Biomechanics Study Group (Faria-Correia, Lopes, Ambrósio), Instituto de Olhos Renato Ambrósio (Lopes, Ambrósio), and VisareRio (Ambrósio), Rio de Janeiro, and the Federal University of São Paulo (Ambrósio), São Paulo, Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Ambrósio
mesh_terms: D057128:Aberrometry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000000981:diagnostic imaging / Q000503:physiopathology*; D019781:Corneal Topography; D057108:Corneal Wavefront Aberration / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003720:Densitometry; D003952:Diagnostic Imaging / Q000379:methods; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007907:Lens Nucleus, Crystalline / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology