title: Effects of parental emotional warmth on the relationship between regional gray matter volume and depression-related personality traits.
abstract: The depression-related personality trait is associated with the severity of patients' current depressive symptoms and with the vulnerability to depression within the nonclinical groups. However, little is known about the anatomical structure associated with the depression-related personality traits within the nonclinical sample. Parenting behavior is associated with the depression symptoms; however, whether or not parenting behavior influence the neural basis of the depression-related personality traits is unclear. Thus in current study, first, we used voxel-based morphometry to identify the brain regions underlying individual differences in depression-related personality traits, as measured by the revised Neuroticism-Extraversion-Openness Personality Inventory, in a large sample of young healthy adults. Second, we use mediation analysis to investigate the relationship between parenting behavior and neural basis of depression-related personality traits. The results revealed that depression-related personality traits were positively correlated with gray matter volume mainly in medial frontal gyrus (MFG) that is implicated in the self-referential processing and emotional regulation. Furthermore, parental emotional warmth acted as a mediational mechanism underlying the association between the MFG volume and the depression-related personality trait. Together, our findings suggested that the family environment might play an important role in the acquisition and process of the depression-related personality traits.
authors.affiliation: a Key Laboratory of Cognition and Personality (SWU) , Ministry of Education , Chongqing , China.|b Department of Psychology , Southwest University , Chongqing , China.
authors.forename: Junyi
authors.initials: J
authors.lastname: Yang
authors.affiliation: c Department of Radiology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yin
authors.affiliation: a Key Laboratory of Cognition and Personality (SWU) , Ministry of Education , Chongqing , China.|b Department of Psychology , Southwest University , Chongqing , China.
authors.forename: Dongtao
authors.initials: D
authors.lastname: Wei
authors.affiliation: a Key Laboratory of Cognition and Personality (SWU) , Ministry of Education , Chongqing , China.|b Department of Psychology , Southwest University , Chongqing , China.
authors.forename: Kangcheng
authors.initials: K
authors.lastname: Wang
authors.affiliation: c Department of Radiology , The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Key Laboratory of Cognition and Personality (SWU) , Ministry of Education , Chongqing , China.|b Department of Psychology , Southwest University , Chongqing , China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000254:growth & development; D003863:Depression / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging* / Q000254:growth & development; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D010287:Parent-Child Relations; D016487:Parenting / Q000523:psychology*; D010551:Personality; D010556:Personality Tests; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D057566:Self Report; D012959:Socioeconomic Factors; D055815:Young Adult
keywords: Depression-related personality trait; medial frontal gyrus (MFG); parental emotional warmth; voxel-based morphometry