title: Triggering of ST-elevation myocardial infarction by ambient wood smoke and other particulate and gaseous pollutants.
abstract: We previously observed increased odds of ST-elevation myocardial infarctions (STEMIs) associated with increased ambient fine particulate matter (PM2.5) in the previous hour. However, data are lacking on the effects of specific PM sources. Using data from 362 patients, a case-crossover design, and conditional logistic regression, we estimated the relative odds of STEMI associated with increased Delta-C (wood smoke), black carbon (BC; traffic), PM2.5, and gaseous pollutants in the previous 1-72 h. We did not observe increased odds of STEMIs associated with increased Delta-C or BC. We did observe increased odds associated with each 7.1 μg/m3increase in PM2.5(OR (95% CI): 1.17 (0.99, 1.39)) and each 19.9 p.p.b. increase in ozone (O3; 1.27 (1.00, 1.63)) in the previous hour, and each 0.22 p.p.m. increase in 48-h carbon monoxide (CO) concentrations (1.32 (1.00, 1.73]). Larger relative odds were associated with PM2.5in May-October, and O3and CO in November-April. Increased PM2.5, O3, and CO, but not wood smoke or BC, were associated with increased odds of STEMI, and effects may differ by season. Studies using spatially adjusted pollution estimates are needed, as well as studies further examining O3and CO effects on the risk of STEMI.
authors.affiliation: Department of Public Health Sciences, University of Rochester, School of Medical Center, Rochester, New York, USA.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Evans
authors.affiliation: Institute for a Sustainable Environment, Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York, USA.
authors.forename: Philip K
authors.initials: PK
authors.lastname: Hopke
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Utell
authors.affiliation: Department of Public Health Sciences, University of Rochester, School of Medical Center, Rochester, New York, USA.
authors.forename: Cathleen
authors.initials: C
authors.lastname: Kane
authors.affiliation: Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: Sally W
authors.initials: SW
authors.lastname: Thurston
authors.affiliation: Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Ling
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: David
authors.initials: D
authors.lastname: Chalupa
authors.affiliation: Department of Public Health Sciences, University of Rochester, School of Medical Center, Rochester, New York, USA.
authors.forename: David Q
authors.initials: DQ
authors.lastname: Rich
mesh_terms: D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D002248:Carbon Monoxide / Q000009:adverse effects* / Q000032:analysis; D018592:Cross-Over Studies; D016208:Databases, Factual; D004562:Electrocardiography; D004784:Environmental Monitoring; D005260:Female; D006785:Hospitals, University; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced*; D009518:New York; D010126:Ozone / Q000009:adverse effects* / Q000032:analysis; D052638:Particulate Matter / Q000009:adverse effects*; D012621:Seasons; D012906:Smoke / Q000009:adverse effects; D001335:Vehicle Emissions; D014934:Wood / Q000009:adverse effects
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D012906:Smoke; D001335:Vehicle Emissions; D010126:Ozone; D002248:Carbon Monoxide