title: Production of Rice Seed-Based Allergy Vaccines.
abstract: Recombinant hypoallergenic derivative is the next generation of tolerogen replacing the natural allergen extract to increase safety and efficacy. Japanese cedar pollinosis is the predominant seasonal allergy disease in Japan. A rice seed-based oral vaccine containing the recombinant hypoallergens derived from these allergens was developed. Efficacy of this rice-based allergy vaccine was evaluated by oral administration in animal models.
authors.affiliation: Functional Crop Research and Development Unit, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba, Ibaraki, 305-8602, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Takagi
authors.affiliation: Functional Crop Research and Development Unit, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba, Ibaraki, 305-8602, Japan. takaiwa@nias.affrc.go.jp.
authors.forename: Fumio
authors.initials: F
authors.lastname: Takaiwa
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006098:Granulocytes / Q000276:immunology; D006632:Histamine / Q000276:immunology; D006967:Hypersensitivity / Q000276:immunology* / Q000517:prevention & control; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D017817:Nasal Lavage Fluid / Q000276:immunology; D012275:Oryza / Q000737:chemistry*; D012639:Seeds / Q000276:immunology*; D012912:Sneezing / Q000276:immunology; D013154:Spleen / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000485:Allergens; D016207:Cytokines; D007074:Immunoglobulin G; D014612:Vaccines; D007073:Immunoglobulin E; D006632:Histamine
keywords: Allergy vaccine; Cedar pollen allergen; Transgenic rice