title: Neuroendocrine Regulation of Growth Hormone Secretion.
abstract: This article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra- and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion in different mammalian species, including Man, according to gender, hormonal environment and ageing. Concerning this last phenomenon, a great body of evidence now supports the role of an attenuation of the GHRH/GH/Insulin-like growth factor-1 (IGF-1) axis in the control of mammalian aging.
authors.affiliation: University of Queensland Centre for Clinical Research and the School of Biomedical Sciences, University of Queensland, St. Lucia, Brisbane, Queensland, Australia.
authors.forename: Frederik J
authors.initials: FJ
authors.lastname: Steyn
authors.affiliation: Unité Mixte de Recherche en Santé 894 INSERM, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Tolle
authors.affiliation: School of Biomedical Sciences, University of Queensland, St. Lucia, Brisbane, Queensland, Australia.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: University of Queensland Centre for Clinical Research and the School of Biomedical Sciences, University of Queensland, St. Lucia, Brisbane, Queensland, Australia.
authors.forename: Jacques
authors.initials: J
authors.lastname: Epelbaum
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism / Q000502:physiology; D004435:Eating; D025461:Feedback, Physiological; D054439:Ghrelin / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008136:Longevity; D009490:Neurosecretory Systems / Q000378:metabolism* / Q000502:physiology
chemical_list: D054439:Ghrelin; D013006:Growth Hormone