title: The long-term outcomes of antiretroviral treatment initiated with mono or dual nucleoside reverse transcriptase inhibitors in HIV-1-infected children: an Asian observational study.
abstract: After a median of 115.9 months of follow-up, 90% of 206 HIV-1-infected children in a cohort in Asia who initiated antiretroviral treatment (ART) with mono or dual nucleoside reverse transcriptase inhibitors were alive and had comparable immunological and virological outcomes as compared to the 1,915 children who had started with highly active antiretroviral regimens. However, these children had higher rates of treatment-related adverse events, opportunistic infections, and cumulative mortality, and were more likely to require protease inhibitor-containing regimens or other more novel ART-based regimens.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Orasri
authors.initials: O
authors.lastname: Wittawatmongkol
authors.affiliation: Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
authors.forename: Thahira J
authors.initials: TJ
authors.lastname: Mohamed
authors.affiliation: Children's Hospital 1, Ho Chi Minh City, Vietnam.
authors.forename: Thoa Pk
authors.initials: TP
authors.lastname: Le
authors.affiliation: University of Health Sciences and National Pediatric Hospital, Phnom Penh, Cambodia.
authors.forename: Vibol
authors.initials: V
authors.lastname: Ung
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Alan
authors.initials: A
authors.lastname: Maleesatharn
authors.affiliation: Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
authors.forename: Rawiwan
authors.initials: R
authors.lastname: Hansudewechakul
authors.affiliation: National Hospital of Pediatrics, Hanoi, Vietnam.
authors.forename: Lam V
authors.initials: LV
authors.lastname: Nguyen
authors.affiliation: YRGCARE Medical Centre, CART CRS, Chennai, India.
authors.forename: Nagalingeswaran
authors.initials: N
authors.lastname: Kumarasamy
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Pagakrong
authors.initials: P
authors.lastname: Lumbiganon
authors.affiliation: Faculty of Medicine and Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Tavitiya
authors.initials: T
authors.lastname: Sudjaritruk
authors.affiliation: HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
authors.forename: Torsak
authors.initials: T
authors.lastname: Bunupuradah
authors.affiliation: Hospital Raja Perempuan Zainab II, Kelantan, Malaysia.
authors.forename: Nik Kn
authors.initials: NK
authors.lastname: Yusoff
authors.affiliation: Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
authors.forename: Nia
authors.initials: N
authors.lastname: Kurniati
authors.affiliation: Hospital Likas, Kota Kinabalu, Malaysia.
authors.forename: Moy S
authors.initials: MS
authors.lastname: Fong
authors.affiliation: Penang Hospital, Penang, Malaysia.
authors.forename: Revathy
authors.initials: R
authors.lastname: Nallusamy
authors.affiliation: The Kirby Institute, UNSW Australia, Sydney, Australia.
authors.forename: Azar
authors.initials: A
authors.lastname: Kariminia
authors.affiliation: TREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
authors.forename: Annette H
authors.initials: AH
authors.lastname: Sohn
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Kulkanya
authors.initials: K
authors.lastname: Chokephaibulkit
keywords: Asia; HIV-infected children; antiretroviral treatment; dual NRTI regimens