title: Direct neural pathways convey distinct visual information to Drosophila mushroom bodies.
abstract: Previously, we demonstrated that visual and olfactory associative memories of Drosophila share mushroom body (MB) circuits (Vogt et al., 2014). Unlike for odor representation, the MB circuit for visual information has not been characterized. Here, we show that a small subset of MB Kenyon cells (KCs) selectively responds to visual but not olfactory stimulation. The dendrites of these atypical KCs form a ventral accessory calyx (vAC), distinct from the main calyx that receives olfactory input. We identified two types of visual projection neurons (VPNs) directly connecting the optic lobes and the vAC. Strikingly, these VPNs are differentially required for visual memories of color and brightness. The segregation of visual and olfactory domains in the MB allows independent processing of distinct sensory memories and may be a conserved form of sensory representations among insects.
authors.affiliation: Max-Planck Institut für Neurobiologie, Martinsried, Germany.|Tohoku University Graduate School of Life Sciences, Sendai, Japan.
authors.forename: Katrin
authors.initials: K
authors.lastname: Vogt
authors.affiliation: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
authors.forename: Yoshinori
authors.identifier: 0000-0002-2939-1688
authors.initials: Y
authors.lastname: Aso
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, United States.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Hige
authors.affiliation: Max-Planck Institut für Neurobiologie, Martinsried, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Knapek
authors.affiliation: Max-Planck Institut für Neurobiologie, Martinsried, Germany.|Tohoku University Graduate School of Life Sciences, Sendai, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ichinose
authors.affiliation: Max-Planck Institut für Neurobiologie, Martinsried, Germany.
authors.forename: Anja B
authors.initials: AB
authors.lastname: Friedrich
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, United States.
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Turner
authors.affiliation: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Rubin
authors.affiliation: Max-Planck Institut für Neurobiologie, Martinsried, Germany.|Tohoku University Graduate School of Life Sciences, Sendai, Japan.
authors.forename: Hiromu
authors.identifier: 0000-0001-5880-6064
authors.initials: H
authors.lastname: Tanimoto
mesh_terms: D000818:Animals; D004330:Drosophila / Q000033:anatomy & histology / Q000502:physiology*; D008568:Memory; D024521:Mushroom Bodies / Q000033:anatomy & histology / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D055696:Olfactory Perception; D009899:Optic Lobe, Nonmammalian / Q000033:anatomy & histology / Q000502:physiology*; D014796:Visual Perception
keywords: D. melanogaster; anatomy; behavior; learning and memory; neural circuit; neuroscience; physiology