title: A Novel EGFR(C797) Variant Detected in a Pleural Biopsy Specimen from an Osimertinib-Treated Patient Using a Comprehensive Hybrid Capture-Based Next-Generation Sequencing Assay.
authors.affiliation: NEO New Oncology AG, Cologne, Germany. Electronic address: menon@newoncology.com.
authors.forename: Roopika
authors.initials: R
authors.lastname: Menon
authors.affiliation: NEO New Oncology AG, Cologne, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Müller
authors.affiliation: NEO New Oncology AG, Cologne, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Schneider
authors.affiliation: NEO New Oncology AG, Cologne, Germany.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Lakis
authors.affiliation: Translational Science, Oncology iMED, AstraZeneca, Waltham, Massachusetts.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Thress
authors.affiliation: Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wolf
authors.affiliation: NEO New Oncology AG, Cologne, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Heukamp
authors.affiliation: NEO New Oncology AG, Cologne, Germany.
authors.forename: Johannes M
authors.initials: JM
authors.lastname: Heuckmann
authors.affiliation: Department of Hematology and Oncology, Pius Hospital, Oldenburg, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Griesinger
mesh_terms: D000178:Acrylamides; D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D000814:Aniline Compounds; D000970:Antineoplastic Agents / Q000009:adverse effects; D001706:Biopsy; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010879:Piperazines / Q000009:adverse effects*; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000235:genetics* / Q000556:secondary; D007211:Indoles; D011743:Pyrimidines
chemical_list: D000178:Acrylamides; D000814:Aniline Compounds; D000970:Antineoplastic Agents; D066246:ErbB Receptors; D010879:Piperazines; C000596361:osimertinib; D007211:Indoles; D011743:Pyrimidines; C512478:EGFR protein, human