title: Two echinocandin-resistant Candida glabrata FKS mutants from South Africa.
abstract: Echinocandins are recommended as first-line agents to treat invasive infections caused by Candida glabrata since this organism is inherently less susceptible to azoles. However, resistance to echinocandins has been described in C. glabrata due to amino acid changes in the hotspot regions of the FKS1 and FKS2 genes. In this report, we describe the first two South African C. glabrata isolates with echinocandin resistance mediated by mutations in the FKS2 gene. Both isolates were cultured from urine specimens from private-sector patients.
authors.affiliation: National Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa.
authors.forename: Serisha D
authors.initials: SD
authors.lastname: Naicker
authors.affiliation: Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: Rindidzani E
authors.initials: RE
authors.lastname: Magobo
authors.affiliation: National Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa.
authors.forename: Thokozile G
authors.initials: TG
authors.lastname: Zulu
authors.affiliation: National Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa.
authors.forename: Tsidiso G
authors.initials: TG
authors.lastname: Maphanga
authors.affiliation: Life Parklands, Springs, South Africa.
authors.forename: Nkosinathi
authors.initials: N
authors.lastname: Luthuli
authors.affiliation: Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Vermaak and Partners Pathologists, Johannesburg, South Africa.
authors.forename: Warren
authors.initials: W
authors.lastname: Lowman
authors.affiliation: National Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: Nelesh P
authors.initials: NP
authors.lastname: Govender
keywords: Candida glabrata; Echinocandin resistance; South Africa