title: BMP-9 enhances fibroblast growth factor 21 expression and suppresses obesity.
abstract: Although BMP-9 has been reported to induce browning of white adipose tissues (WATs) and suppress high fat diet-induced obesity, detailed molecular mechanism needs to be further elucidated. We report here that administration of MB109, a recombinant derivative of human BMP-9, into obese mice enhanced gene expression of fibroblast growth factor 21 (FGF21), a metabolic regulator, and alleviates a spectrum of pathological symptoms due to high fat diet-induced obesity. In addition, periodical injection of MB109 (500μg/kg/week) reduced an amount of lipid droplets in the liver, serum levels of alanine aminotransferase (ALT), and total cholesterol. These results indicate that MB109 is also effective to treat obesity-mediated non-alcoholic fatty liver disease (NAFLD).
authors.affiliation: Laboratory of Drugs to Medicine, Joint Center for Biosciences, Incheon 406-840, South Korea.
authors.forename: Sooho
authors.initials: S
authors.lastname: Kim
authors.affiliation: Laboratory of Synthetic Biology, Joint Center for Biosciences, Incheon 406-840, South Korea; Drug Discovery Collaboratory, 9500 Gilman Drive, San Diego, CA 92093, USA. Electronic address: schoe@ddcoll.org.
authors.forename: Senyon
authors.initials: S
authors.lastname: Choe
authors.affiliation: Laboratory of Drugs to Medicine, Joint Center for Biosciences, Incheon 406-840, South Korea. Electronic address: dklee.jcb@gmail.com.
authors.forename: Dong Kun
authors.initials: DK
authors.lastname: Lee
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D005346:Fibroblast Growth Factors / Q000235:genetics*; D055427:Growth Differentiation Factor 2; D055412:Growth Differentiation Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D000071256:Uncoupling Protein 1 / Q000235:genetics; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; C525887:GDF2 protein, human; D055427:Growth Differentiation Factor 2; D055412:Growth Differentiation Factors; D011994:Recombinant Proteins; C000604372:Ucp1 protein, mouse; D000071256:Uncoupling Protein 1; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D002784:Cholesterol; D000410:Alanine Transaminase
keywords: ALT; BMP-9; FGF21; Obesity; Stem cell; UCP1