title: Biodegradable, elastomeric coatings with controlled anti-proliferative agent release for magnesium-based cardiovascular stents.
abstract: Vascular stent design continues to evolve to further improve the efficacy and minimize the risks associated with these devices. Drug-eluting coatings have been widely adopted and, more recently, biodegradable stents have been the focus of extensive evaluation. In this report, biodegradable elastomeric polyurethanes were synthesized and applied as drug-eluting coatings for a relatively new class of degradable vascular stents based on Mg. The dynamic degradation behavior, hemocompatibility and drug release were investigated for poly(carbonate urethane) urea (PCUU) and poly(ester urethane) urea (PEUU) coated magnesium alloy (AZ31) stents. Poly(lactic-co-glycolic acid) (PLGA) coated and bare stents were employed as control groups. The PCUU coating effectively slowed the Mg alloy corrosion in dynamic degradation testing compared to PEUU-coated, PLGA-coated and bare Mg alloy stents. This was confirmed by electron microscopy, energy-dispersive x-ray spectroscopy and magnesium ion release experiments. PCUU-coating of AZ31 was also associated with significantly reduced platelet adhesion in acute blood contact testing. Rat vascular smooth muscle cell (rSMC) proliferation was successfully inhibited when paclitaxel was released from pre-loaded PCUU coatings. The corrosion retardation, low thrombogenicity, drug loading capacity, and high elasticity make PCUU an attractive option for drug eluting coating on biodegradable metallic cardiovascular stents.
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors.forename: Xinzhu
authors.initials: X
authors.lastname: Gu
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA; School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Mao
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Ye
authors.affiliation: National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A & T State University, Greensboro, NC 27411, USA.
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Koo
authors.affiliation: National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A & T State University, Greensboro, NC 27411, USA.
authors.forename: Yeoheung
authors.initials: Y
authors.lastname: Yun
authors.affiliation: College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Tarannum R
authors.initials: TR
authors.lastname: Tiasha
authors.affiliation: College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Vesselin
authors.initials: V
authors.lastname: Shanov
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: wagnerwr@upmc.edu.
authors.forename: William R
authors.initials: WR
authors.lastname: Wagner
mesh_terms: D000497:Alloys; D000818:Animals; D002318:Cardiovascular Diseases / Q000628:therapy*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D054855:Drug-Eluting Stents; D020724:Elastomers; D007477:Ions; D008274:Magnesium / Q000494:pharmacology*; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000187:drug effects; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D012756:Sheep; D013499:Surface Properties; D055114:X-Ray Microtomography
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D020724:Elastomers; D007477:Ions; C586533:Mg-Al-Zn-Mn-Si-Cu alloy; D011108:Polymers; C036925:elastomeric polymer; D008274:Magnesium
keywords: Drug eluting coating; Magnesium stents; Polymer coating