title: RNase 7 in Cutaneous Defense.
abstract: RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases.
authors.affiliation: Department of Dermatology, University of Kiel, 24105 Kiel, Germany. frademacher@dermatology.uni-kiel.de.
authors.forename: Franziska
authors.initials: F
authors.lastname: Rademacher
authors.affiliation: Department of Dermatology, University of Kiel, 24105 Kiel, Germany. msimanski@dermatology.uni-kiel.de.
authors.forename: Maren
authors.initials: M
authors.lastname: Simanski
authors.affiliation: Department of Dermatology, University of Kiel, 24105 Kiel, Germany. jharder@dermatology.uni-kiel.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Harder
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000032:analysis / Q000276:immunology*; D001419:Bacteria / Q000276:immunology; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D018407:Bacterial Physiological Phenomena; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D012260:Ribonucleases / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D012867:Skin / Q000276:immunology / Q000382:microbiology* / Q000821:virology*; D012871:Skin Diseases / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000276:immunology
chemical_list: D000890:Anti-Infective Agents; D012260:Ribonucleases; C470000:Ribonuclease 7
keywords: RNase 7; antimicrobial peptides (AMPs); cutaneous defense