title: The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy.
abstract: The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS has the potential to optimize the creation of an anterior lens capsulotomy, a critical step in accessing the cataractous lens. The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture. In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable. While there was no demonstrable difference in the resistance to rupture before or after the removal of the nucleus, larger capsulotomies had an increase in tensile strength. The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.|Corneal and External Eye Disease Service, Singapore National Eye Centre, Singapore, Singapore.
authors.forename: Geraint P
authors.initials: GP
authors.lastname: Williams
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.
authors.forename: Ben L
authors.initials: BL
authors.lastname: George
authors.affiliation: Biomechanics Laboratory, Singapore General Hospital, Singapore, Singapore.
authors.forename: Yoke R
authors.initials: YR
authors.lastname: Wong
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Seah
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.
authors.forename: Heng-Pei
authors.initials: HP
authors.lastname: Ang
authors.affiliation: Biomechanics Laboratory, Singapore General Hospital, Singapore, Singapore.
authors.forename: Mun Kitt A
authors.initials: MK
authors.lastname: Loke
authors.affiliation: Biomechanics Laboratory, Singapore General Hospital, Singapore, Singapore.|Department of Hand Surgery, Singapore General Hospital, Singapore, Singapore.
authors.forename: Shian Chao
authors.initials: SC
authors.lastname: Tay
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.|Corneal and External Eye Disease Service, Singapore National Eye Centre, Singapore, Singapore.
authors.forename: Jod S
authors.initials: JS
authors.lastname: Mehta
mesh_terms: D000818:Animals; D002386:Cataract / Q000473:pathology / Q000628:therapy*; D002387:Cataract Extraction / Q000379:methods; D005123:Eye / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D053685:Laser Therapy; D007908:Lens, Crystalline / Q000528:radiation effects / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures / Q000379:methods; D064727:Posterior Capsulotomy; D013552:Swine