title: New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan.
abstract: We have characterized in detail a new ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3'-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread.
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Nakayama
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shimuta
authors.affiliation: Sonezaki Furubayashi Clinic, Osaka, Japan.
authors.forename: Kei-Ichi
authors.initials: K
authors.lastname: Furubayashi
authors.affiliation: Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kawahata
authors.affiliation: WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Unemo
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan ohnishi7@niid.go.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohnishi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D002443:Ceftriaxone / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D007564:Japan; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics*; D046915:Penicillin-Binding Proteins / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; D002443:Ceftriaxone