title: Factors related to local recurrence of non small cell lung cancer and its operability.
abstract: OBJECTIVE
  To analyze the correlation of primary tumor (PT) pathological characteristics (size, stage, type and grade) and the extent of initial surgical treatment of non small cell lung cancer (NSCLC) with the incidence and time to local recurrence (LR) and disease-free survival (DFS), as well as to determine in what way these parameters and LR localizations affect the possibility for surgical retreatment.
  
  
  METHODS
  The research was conducted on 114 patients with NSCLC and LR that had initial surgery in two reference institutes in Serbia from January 2002 to December 2010. PT size and disease stage were defined according to the revised 2004 WHO classification. PTs were grouped by size into 3 categories. Due to great diversity, surgical procedures were sorted into 6 operation types. Standard statistical methods and tests were used for data analysis.
  
  
  RESULTS
  Statistical analyses showed significant difference in DFS and LR reoperability that were related to PT size, disease stage and the extent of initial surgery. LR localization on the chest wall was favorable for secondary surgery due to LR.
  
  
  CONCLUSIONS
  Squamous cell lung carcinoma relapses locally more frequently than other lung tumor types, and the commonest LR site is the chest wall. This localization provides high possibility for surgical retreatment. Adequate staging, proper indications for surgical treatment and quality surgery provide longer DFS in patients with NSCLC. All these suggest that the surgeon may be considered as the most significant factor of prognosis.
authors.affiliation: Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
authors.forename: Dejan
authors.initials: D
authors.lastname: Stojiljkovic
authors.forename: Nada
authors.initials: N
authors.lastname: Santrac
authors.forename: Merima
authors.initials: M
authors.lastname: Goran
authors.forename: Tanja
authors.initials: T
authors.lastname: Stojiljkovic
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Miletic
authors.forename: Dusica
authors.initials: D
authors.lastname: Gavrilovic
authors.forename: Igor
authors.initials: I
authors.lastname: Spurnic
authors.forename: Marko
authors.initials: M
authors.lastname: Jevric
authors.forename: Stevan
authors.initials: S
authors.lastname: Jokic
authors.forename: Ivan
authors.initials: I
authors.lastname: Markovic
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*