title: Indoor Dust Allergen Levels in the Homes of Patients with Childhood Asthma: An Experience From Southwestern Iran.
abstract: Exposure to indoor allergens plays an important role in the etiology of asthma. This study was designed to quantify indoor allergens from homes of families that had at least one case of childhood asthma at home in a southwestern city of Iran. The relationship between the indoor allergen levels and home characteristics was also investigated. Dust samples were collected from the bedrooms and the kitchens of 35 homes where children with persistent asthma were living. The levels of indoor allergens were measured by enzyme linked immunosorbent assay (ELISA). Detectable amounts of mite, mouse and cockroach allergens were found in all evaluated places. None of our patients were exposed to a threshold concentration of indoor allergen for sensitizing at home. Regarding of mite allergens, the levels of Der f1 were significantly higher than Der p1 and a direct correlation was observed between living in an apartment and Der f1 levels. Moreover, Fel d1 (cat) and Bla g1 (cockroach) allergens were found in the children's bedrooms more frequently than those in the kitchens. In this study, direct associations were obtained between Bla g1 allergen and the duration of occupancy and between Fel d1 and average home size. A total of 34.2% of the patients showed positive skin reactions to at least one of the tested allergens as 17.1% of them showed reactivity to D. pteronyssinus. Proper controlling of cockroaches and mice by public health officials would be a practical approach to avoid inducing asthma or worsening the symptoms.
authors.affiliation: Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Allergy Clinic of Ali-Asghar Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Moghtaderi
authors.affiliation: Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Farjadian
authors.affiliation: Asthma, Allergy and Immunology Research Center, Birjand University of Medical Sciences, Birjand, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fereidouni
authors.affiliation: Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Nasiri
authors.affiliation: Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Arsalan
authors.initials: A
authors.lastname: Nejat
mesh_terms: D000293:Adolescent; D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000032:analysis*; D000485:Allergens / Q000032:analysis / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000453:epidemiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006798:Housing; D006801:Humans; D007223:Infant; D008297:Male; D051379:Mice
chemical_list: D000485:Allergens
keywords: Allergens; Asthma; House dust; Immunologic sensitization