title: Clinical variability and molecular heterogeneity in prostate cancer.
abstract: Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic heterogeneity that contributes to these varying clinical phenotypes. Distinct molecular sub-classes of prostate cancer have been identified, and the uniqueness of these sub-classes has been leveraged to predict clinical outcomes, design novel biomarkers for prostate cancer diagnosis, and develop novel therapeutics. Recent work has also elucidated the temporal and spatial heterogeneity of prostate cancer, helping us understand disease pathogenesis, response to therapy, and progression. New genomic techniques have provided us with a window into the remarkable clinical and genomic heterogeneity of prostate cancer, and this new perspective will increasingly impact patient care.
authors.affiliation: Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medical College, New York, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shoag
authors.affiliation: Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medical College, New York; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, USA.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Barbieri
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000473:pathology; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor