title: Carbohydrate CuAAC click chemistry for therapy and diagnosis.
abstract: Carbohydrates are important as signaling molecules and for cellular recognition events, therefore offering scope for the development of carbohydrate-mimetic diagnostics and drug candidates. As a consequence, the construction of carbohydrate-based bioactive compounds and sensors has become an active research area. While the advent of click chemistry has greatly accelerated the progress of medicinal chemistry and chemical biology, recent literature has seen an extensive use of such approaches to construct functionally diverse carbohydrate derivatives. Here we summarize some of the progress, covering the period 2010 to mid-2015, in Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition CuAAC "click chemistry" of carbohydrate derivatives, in the context of potential therapeutic and diagnostic tool development.
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology (ECUST), 130 Meilong Rd., Shanghai 200237, PR China.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: He
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology (ECUST), 130 Meilong Rd., Shanghai 200237, PR China.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Zeng
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), 189 Guo Shoujing Rd., Shanghai 201203, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zang
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), 189 Guo Shoujing Rd., Shanghai 201203, PR China. Electronic address: jli@simm.ac.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: Rob.Field@jic.ac.uk.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Field
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology (ECUST), 130 Meilong Rd., Shanghai 200237, PR China. Electronic address: mrs_guorongchen@ecust.edu.cn.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Chen
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001386:Azides / Q000737:chemistry; D002241:Carbohydrates / Q000138:chemical synthesis / Q000627:therapeutic use; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D057930:Click Chemistry / Q000379:methods* / Q000639:trends; D061565:Cycloaddition Reaction; D006031:Glycosylation; D006801:Humans; D050111:Imino Sugars / Q000138:chemical synthesis / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction; D014230:Triazoles / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D000480:Alkynes; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001386:Azides; D002241:Carbohydrates; D050111:Imino Sugars; D014230:Triazoles
keywords: Carbohydrate; Click chemistry; CuAAC; Diagnosis; Therapy