title: Bevacizumab-induced chronic interstitial pneumonia during maintenance therapy in non-small cell lung cancer.
abstract: Bevacizumab is a monoclonal antibody targeting the vascular endothelial growth factor receptor and a key drug for advanced non-small cell lung cancer. There are few reports describing bevacizumab-induced chronic interstitial pneumonia. A 62-year-old man with advanced non-small cell lung cancer was admitted to our hospital with dyspnea. He previously received four courses of carboplatin plus paclitaxel with bevacizumab combination therapy and thereafter received four courses of maintenance bevacizumab monotherapy. A chest-computed tomography scan on admission revealed diffuse ground glass opacity. He had not received any other drugs and did not have pneumonia. Thus, he was diagnosed with bevacizumab-induced chronic interstitial pneumonia and was treated with a high dose of corticosteroids. After steroid treatment, his dyspnea and radiological findings improved. This case report is the first description of bevacizumab-induced chronic interstitial pneumonia during maintenance therapy in a patient with non-small cell lung cancer.
authors.affiliation: Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Sekimoto
authors.affiliation: Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Kato
authors.affiliation: Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Shukuya
authors.affiliation: Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Koyama
authors.affiliation: Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Nagaoka
authors.affiliation: Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
keywords: bevacizumab; chemotherapy; drug‐induced chronic interstitial pneumonia; molecular target drug; non‐small cell lung cancer