title: High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody.
abstract: Cancer can occur in patients with inflammatory myopathies. This association is mainly observed in dermatomyositis, and myositis-specific antibodies have allowed us to delineate patients at an increased risk. Malignancy is also reported in patients with necrotizing autoimmune myopathies, but the risk remains elusive. Anti-signal recognition particle or anti-HMGCR antibodies have been specifically associated with necrotizing autoimmune myopathies. We aimed at screening the incidence of cancer in necrotizing autoimmune myopathies. A group of patients (n = 115) with necrotizing autoimmune myopathies with or without myositis-specific antibodies was analysed. Malignancy occurred more frequently in seronegative necrotizing autoimmune myopathies patients and in HMGCR-positive patients compared to anti-signal recognition particle positive patients. Synchronous malignancy was diagnosed in 21.4% and 11.5% of cases, respectively, and incidence of cancer was higher compared to the general population in both groups. No specific type of cancer was predominant. Patients suffering from a synchronous cancer had a decreased median survival time. Cancer screening is necessary in seronegative necrotizing autoimmune myopathies and in HMGCR-positive patients but not in anti-signal recognition particle-positive patients.
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France 2 INSERM U974, UPMC Sorbonne Universités, Paris, France yves.allenbach@psl.aphp.fr.
authors.forename: Yves
authors.initials: Y
authors.lastname: Allenbach
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Keraen
authors.affiliation: 3 Registre Bourguignon des Cancers Digestifs, INSERM U866, CHU Dijon, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Bouvier
authors.affiliation: 3 Registre Bourguignon des Cancers Digestifs, INSERM U866, CHU Dijon, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Jooste
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Champtiaux
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Hervier
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France.
authors.forename: Yoland
authors.initials: Y
authors.lastname: Schoindre
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Rigolet
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Gilardin
authors.affiliation: 4 Département d'Immunochimie, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Sorbonne Universités, Paris, France.
authors.forename: Lucile
authors.initials: L
authors.lastname: Musset
authors.affiliation: 4 Département d'Immunochimie, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Sorbonne Universités, Paris, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Charuel
authors.affiliation: 5 Laboratoire d'Immunologie, U905, Hôpital Universitaire de Rouen, Université Normandie, IRIB, Inserm, Rouen, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Boyer
authors.affiliation: 5 Laboratoire d'Immunologie, U905, Hôpital Universitaire de Rouen, Université Normandie, IRIB, Inserm, Rouen, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Jouen
authors.affiliation: 5 Laboratoire d'Immunologie, U905, Hôpital Universitaire de Rouen, Université Normandie, IRIB, Inserm, Rouen, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Drouot
authors.affiliation: 5 Laboratoire d'Immunologie, U905, Hôpital Universitaire de Rouen, Université Normandie, IRIB, Inserm, Rouen, France.
authors.forename: Jeremie
authors.initials: J
authors.lastname: Martinet
authors.affiliation: 6 Centre de référence de pathologie neuromusculaire Paris-Est, Institut de Myologie, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Sorbonne Universités, Paris, France.
authors.forename: Tanya
authors.initials: T
authors.lastname: Stojkovic
authors.affiliation: 6 Centre de référence de pathologie neuromusculaire Paris-Est, Institut de Myologie, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Sorbonne Universités, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Eymard
authors.affiliation: 6 Centre de référence de pathologie neuromusculaire Paris-Est, Institut de Myologie, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Sorbonne Universités, Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Laforêt
authors.affiliation: 6 Centre de référence de pathologie neuromusculaire Paris-Est, Institut de Myologie, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Sorbonne Universités, Paris, France.
authors.forename: Antony
authors.initials: A
authors.lastname: Behin
authors.affiliation: 7 Centre de référence des maladies neuromusculaires et de la SLA, Centre hospitalier universitaire la Timone, Université Aix-Marseille, Marseille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Salort-Campana
authors.affiliation: 8 Département de Médecine Interne, Hôpital Saint Antoine, AP-HP, UPMC Sorbonne Universités, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Fain
authors.affiliation: 9 Département de Physiologie, Nouvel Hôpital civil, Strasbourg, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Meyer
authors.affiliation: 10 Département de Médecine Interne, Centre hospitalier universitaire la Timone, Université Aix-Marseille, Marseille, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Schleinitz
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France 2 INSERM U974, UPMC Sorbonne Universités, Paris, France.
authors.forename: Kuberaka
authors.initials: K
authors.lastname: Mariampillai
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France.
authors.forename: Aurelie
authors.initials: A
authors.lastname: Grados
authors.affiliation: 1 Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, DHU I2B, AP-HP, Paris, France 2 INSERM U974, UPMC Sorbonne Universités, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Benveniste
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood* / Q000453:epidemiology; D015897:Comorbidity; D003882:Dermatomyositis / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000097:blood* / Q000453:epidemiology; D009220:Myositis / Q000276:immunology*; D009369:Neoplasms / Q000097:blood* / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; C553220:HMGCR protein, human; D006903:Hydroxymethylglutaryl CoA Reductases
keywords: auto-antibodies; cancer; necrotizing autoimmune myopathies; polymyositis