title: Association between rs6887695 and 3'-untranslated region polymorphisms within the interleukin-12B gene and susceptibility to autoimmune diseases in Asian and European population: A meta-analysis.
abstract: The associations between rs6887695 and 3'-untranslated region (3'-UTR) single-nucleotide polymorphisms (SNPs) within interleukin-12B (IL-12B) and autoimmune diseases (ADs) remain controversial and inconclusive. The aim of this study was to evaluate the association between IL-12B (3'-UTR A/C and rs6887695 C/G SNPs) and ADs by meta-analysis.
  
  
  
  PubMed and EMBASE were exhaustively searched for studies on the association between IL-12B SNPs and ADs. Publication bias was examined by a funnel plot and Egger's test. The robustness of the pooled results was assessed by sensitivity analysis. A fixed- or a random-effects model was applied to calculate the pooled odds ratios (ORs).
  
  
  
  A total of 34 studies were included in this meta-analysis. The pooled results demonstrated that IL-12B rs6887695 SNPs were significantly associated with the risk of ADs. However, there was no significant association between IL-12B 3'-UTR SNPs and ADs. When the studies were stratified by ethnicity, significant association between IL-12B 3'-UTR SNPs and ADs was observed in both Asian and European population. In addition, allele A within 3'-UTR of IL-12B gene was found to be a protective factor for T1DM, but a risk factor for psoriasis.
  
  
  
  The IL-12B 3'-UTR and rs6887695 SNPs are associated with susceptibility to ADs.
authors.affiliation: a Department of Nephrology , The Second Affiliated Hospital of Anhui Medical University , Anhui , China and.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Xiao
authors.affiliation: a Department of Nephrology , The Second Affiliated Hospital of Anhui Medical University , Anhui , China and.
authors.forename: Xue-Rong
authors.initials: XR
authors.lastname: Wang
authors.affiliation: a Department of Nephrology , The Second Affiliated Hospital of Anhui Medical University , Anhui , China and.
authors.forename: Sen
authors.initials: S
authors.lastname: Zhang
authors.affiliation: a Department of Nephrology , The Second Affiliated Hospital of Anhui Medical University , Anhui , China and.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wang
authors.affiliation: a Department of Nephrology , The Second Affiliated Hospital of Anhui Medical University , Anhui , China and.
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.affiliation: b Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Anhui , China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.affiliation: a Department of Nephrology , The Second Affiliated Hospital of Anhui Medical University , Anhui , China and.
authors.forename: De-Guang
authors.initials: DG
authors.lastname: Wang
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40
keywords: Autoimmune disease (AD); IL-12B 3′-untranslated region; IL-12B rs6887695; meta-analysis; polymorphism