title: Nickel(0)-catalyzed intramolecular reductive coupling of alkenes and aldehydes or ketones with hydrosilanes.
abstract: A nickel(0)-catalyzed reductive coupling of aldehydes and simple alkenes with hydrosilanes has been developed. A variety of silyl-protected 1-indanol derivatives were prepared in a highly diastereoselective manner (up to >99 : 1 dr) by employing a combination of nickel(0)/N-heterocyclic carbene and triethylsilane. The present system was also applied to a reductive coupling with ketones. Preliminary results of a nickel(0)-catalyzed asymmetric three-component coupling reaction of an aldehyde, an alkene, and triethylsilane are also shown.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. ogoshi@chem.eng.osaka-u.ac.jp.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hoshimoto
authors.forename: Ravindra
authors.initials: R
authors.lastname: Kumar
authors.forename: Masato
authors.initials: M
authors.lastname: Ohashi
authors.forename: Sensuke
authors.initials: S
authors.lastname: Ogoshi