title: Sensitization profiles to peanut allergens in Belgium; cracking the code in infants, children and adults.
abstract: OBJECTIVE
  Peanut allergy shows distinct clinical patterns that can be predicted by component resolved diagnosis. However, data about peanut sensitization profiles in populations with a broad age stratification are scarce.
  
  
  METHODS
  Sera of 89 peanut allergic patients (age 1-70 years), 21 infants (<1 year) with atopic dermatitis (AD) sensitized to peanut, 24 age matched peanut-tolerant individuals with positive specific IgE (sIgE) to peanut and 15 healthy individuals were tested for sIgE reactivity to rAra h 1, rAra h 2, rAra h 3, rAra h 8, rAra h 9 and rBet v 1 (FEIA ImmunoCAP, Thermo Fisher Scientific).
  
  
  RESULTS
  In infants with AD, Ara h 1, Ara h 2 and Ara h 3 enabled to explain 14/21 (67%) of peanut sensitizations. No sensitization to Ara h 8 or Bet v 1 was observed. Patients with generalized reactions were more frequently sensitized to Ara h 1, Ara h 2 and Ara h 3 compared to patients with an oral allergy syndrome (OAS) and peanut-tolerant patients. Sensitization to Ara h 8 was significantly more observed in patients with an OAS. Ara h 2 showed to be the best marker to distinguish patients with generalized reactions from patients with an OAS and/or peanut sensitized patients but tolerating the legume.
  
  
  CONCLUSIONS
  Sensitization to Ara h 1, Ara h 2 and Ara h 3 can have an early onset and is predominantly associated with a more severe outcome. Ara h 2 is the best marker of a generalized peanut allergy.
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Margaretha A
authors.initials: MA
authors.lastname: Faber
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Inne
authors.initials: I
authors.lastname: Donné
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Evelien
authors.initials: E
authors.lastname: Herrebosch
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Vito
authors.initials: V
authors.lastname: Sabato
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.|b Department of Pediatrics , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Margo M
authors.initials: MM
authors.lastname: Hagendorens
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Chris H
authors.initials: CH
authors.lastname: Bridts
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Luc S
authors.initials: LS
authors.lastname: De Clerck
authors.affiliation: a Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology , University of Antwerp and Antwerp University Hospital , Antwerp , Belgium.
authors.forename: Didier G
authors.initials: DG
authors.lastname: Ebo
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology; D052179:Antigens, Plant / Q000276:immunology; D010367:Arachis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D021183:Peanut Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D055815:Young Adult
chemical_list: D000485:Allergens; D052179:Antigens, Plant
keywords: Ara h 2; Component resolved diagnosis; Food allergy; Peanut allergy