title: Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review.
abstract: The current study reports the case of a patient with Philadelphia chromosome-negative (Ph-) non-Hodgkin's lymphoma (NHL) and chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) that also possessed characteristic enlarged lymph nodes. A lymph node biopsy resulted in the diagnosis of CP-CML, in addition to T-lymphoblastic cell NHL with negative break point cluster/Abelson tyrosine kinase fusion genes in the lymph node of the patient, which was diagnosed as Ph-NHL. A review of the literature was performed in the present study to investigate the genetic differences between Ph-NHL and Ph+NHL in patients with CML. The median age of patients with NHL and CML was 41 years. The follow-up time of patients with Ph+NHL was significantly shorter (mean, <6 months) compared to the follow-up time of patients with Ph-NHL (mean, >15 months). Therefore the present study concludes that Ph+NHL may be more aggressive compared with Ph+NHL. The present study suggests that additional studies are required to assess the clinical and genetic characteristics of NHL patients with CML.
authors.affiliation: Department of Hematology, Yunnan Tumor Hospital, Kunming, Yunnan 650118, P.R. China.
authors.forename: Zheng-Lei
authors.initials: ZL
authors.lastname: Shen
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, P.R. China.
authors.forename: Lie-Fen
authors.initials: LF
authors.lastname: Yin
authors.affiliation: Department of Geriatrics, Kunming Second People's Hospital, Kunming, Yunnan 650204, P.R. China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Mao
authors.affiliation: Department of Hematology, Yunnan Tumor Hospital, Kunming, Yunnan 650118, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, P.R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
keywords: chronic myelogenous leukemia; fusion gene; non-Hodgkin's lymphomas; philadelphia chromosome