title: Predictors of recurrent venous thromboembolism and bleeding on anticoagulation.
abstract: The impact of venous thromboembolism (VTE) in the cancer population remains substantial despite significant advances in detecting and treating thrombotic events. While there is extensive literature regarding predictors of first VTE event in cancer patients as well as a validated predictive score, less data exist regarding recurrent VTE in cancer cohorts and associated predictive variables. A similar paucity of data in regard to bleeding events in cancer patients receiving anticoagulation has been observed. This review article will highlight clinical risk factors as well as predictive biomarkers associated with recurrent VTE and bleeding in cancer patients receiving therapeutic anticoagulation. Predictive risk assessment models for cancer-associated recurrent VTE and bleeding are also discussed.
authors.affiliation: Taussig Cancer Institute, Department of Hematology Oncology, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Laurel A
authors.initials: LA
authors.lastname: Menapace
authors.affiliation: Taussig Cancer Institute, Department of Hematology Oncology, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Keith R
authors.initials: KR
authors.lastname: McCrae
authors.affiliation: Taussig Cancer Institute, Department of Hematology Oncology, Cleveland Clinic, Cleveland, Ohio, USA. Electronic address: Khorana@ccf.org.
authors.forename: Alok A
authors.initials: AA
authors.lastname: Khorana
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D006470:Hemorrhage / Q000139:chemically induced; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D012008:Recurrence; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight
keywords: Bleeding; Cancer; Recurrent thromboembolism; Risk factors; Thrombosis