title: Serum Uric Acid Is Positively Associated with Handgrip Strength among Japanese Community-Dwelling Elderly Women.
abstract: Serum uric acid (UA) has strong anti-oxidant properties. Muscle strength and mass decrease with age, and recently, this decrease has been defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether serum UA is associated with handgrip strength (HGS), which is a useful indicator of sarcopenia, among Japanese community-dwelling elderly persons. The present study included 602 men aged 72 ± 7 years and 847 women aged 71 ± 6 years from a rural village. We examined the cross-sectional relationship between serum UA and HGS. In both genders, HGS increased significantly with increased serum UA levels. A multiple linear regression analysis using HGS as an objective variable and various confounding factors as explanatory variables showed that in men age, drinking status, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and estimated glomerular filtration ratio (eGFRCKDEPI) were independently and significantly associated with HGS, and in women, serum UA as well as age, body mass index, drinking status, diastolic blood pressure, and eGFRCKDEPI were independently and significantly associated with HGS. In women, age and multivariate-adjusted HGS were significantly higher in the Quartile-3 (4.8-5.4 mg/dL) and Quartile-4 groups (5.5-9.3 mg/dL) of serum UA than in the lower groups (0.7-4.7 mg/dL). These results suggest that serum UA may have a protective role in aging-associated decline in muscle strength in community-dwelling elderly women.
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.|Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, 797-1212, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.|Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, 797-1212, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ninomiya
authors.affiliation: Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, 797-1212, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kasai
authors.affiliation: Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, 797-1212, Japan.
authors.forename: Tomo
authors.initials: T
authors.lastname: Kusunoki
authors.affiliation: Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, 797-1212, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohtsuka
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
authors.forename: Teru
authors.initials: T
authors.lastname: Kumagi
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D007564:Japan; D008297:Male; D018384:Oxidative Stress; D012307:Risk Factors; D055948:Sarcopenia / Q000097:blood / Q000175:diagnosis*; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014527:Uric Acid