title: [Effect of 1, 2, 3, 4, 6, 7, 8, 9-octachlorodibenzo-p-dioxin on testicular gene expression profiles in male mice].
abstract: OBJECTIVE
  To investigate the effect of 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin (OCDD) on the testicular gene expression profile in the testis of mice.
  
  
  METHODS
  Twenty male C57BL/6j mice were randomly divided into normal control group (fed with maize oil) and 3 OCDD groups treated with OCDD by gavage for 30 days at low-, moderate-, and high doses of 1.25×10(-6), 1.25 ×10(-5), and 1.25×10(-4) g/mL, respectively (8 mL/kg daily). The testicular gene expression profiles of the mice were investigated using gene chip technique and compared between OCDD-exposed groups and the control group.
  
  
  RESULTS
  Compared with the control group, the mice in low-dose OCDD group showed 1133 differentially expressed genes, including 659 up-regulated and 474 down-regulated ones; in the moderate-dose OCDD group, 978 genes were differentially expressed, including 487 up-regulated and 491 down-regulated ones; in the high-dose group, 895 genes were differentially expressed, including 424 up-regulated and 471 down-regulated ones.
  
  
  CONCLUSIONS
  The effect of sub-chronic exposure to OCDD on testicular gene expression profiles in male C57BL/6j mice indicates that the testis is probably the target organ of OCDD.
authors.affiliation: School of Basic Medical Science, Xinxiang Medical University, Xinxiang 453003, China.E-mail: zhangwei0920@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yao-Feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Tian-Jun
authors.initials: TJ
authors.lastname: Ni
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Yang
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020411:Oligonucleotide Array Sequence Analysis; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D000072317:Polychlorinated Dibenzodioxins; C018117:octachlorodibenzo-4-dioxin