title: Predictive prognostic value of local and distant recurrence of F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to World Health Organization classifications (2004, 2010). Case series study.
abstract: BACKGROUND
  F-flurodeoxyglucose positron emission tomography (FDG-PET) have been claimed to be an important prognostic tool in different malignancies. However, its predictive prognostic value on pancreatic neuroendocrine tumors (PNETs) is still under investigation.
  
  
  OBJECTIVE
  We study the prognostic impact of FDG-PET scan in neuroendocrine pancreatic tumors.
  
  
  METHODS
  Between 2007 and 2012, 26 patients with no metastastatic histologically confirmed PNETs (mean age: 57 years) were examined with FDG-PET. We studied its captation in relation with the well established hystopathological prognostic markers assessed in the tumoral resected specimen according to the WHO 2004 and ENETS/WHO 2010 classification.
  
  
  RESULTS
  FDG-PET captation was positive in 17 cases (65.4%). The median follow-up period was 34.4 months and recurrences occurred in 4 cases (15.4%). We found a significant correlation between this captation and Ki 67 index (p = 0.032), mitotic index (p = 0.002), tumor grade (p = 0.017) and tumor size (p = 0.01).
  
  
  CONCLUSIONS
  FDG-PET provides a good prognostic value for PNETs. Present results must be further validated with larger sample studies.
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: H J
authors.initials: HJ
authors.lastname: Durán
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain. Electronic address: ielpo.b@gmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Ielpo
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Díaz
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Fabra
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Caruso
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Malavé
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Cano-Valderrama
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Garcia
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: Y
authors.initials: Y
authors.lastname: Quijano
authors.affiliation: Sanchinarro University Hospital, Calle Oña 10, 28050, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Vicente
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D018358:Neuroendocrine Tumors / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D047368:Tumor Burden; D014944:World Health Organization
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: F-fluorodeoxyglucose positron emission tomography; Pancreatic neuroendocrine tumors; WHO classifications