title: Angiotensin-II blockage, muscle strength, and exercise capacity in physically independent older adults.
abstract: [Purpose] This study aimed to assess the exercise capacity and muscle strength in elderly people using drugs for angiotensin-II blockage. [Subjects and Methods] Four hundred and seven older adults were recruited for this study. Data about comorbidities and medication use were recorded and the individuals were divided into three groups: control group- elderly people with normal exercise capacity (n=235); angiotensin-converting enzyme inhibitor group - individuals using angiotensin-converting enzyme inhibitors (n=140); and angiotensin-II receptor blocker group- patients using angiotensin-II receptor blockers (n= 32). Exercise capacity was evaluated by a 6-minute walking test and muscle strength was measured using a handgrip dynamometer. [Results] Patients from the angiotensin-converting enzyme inhibitor group (mean: 99 ± 12%) and the angiotensin-II receptor blocker group (mean: 101 ± 14%) showed higher predicted values in the 6-minute walking test than the control group patients (mean: 96 ± 10%). Patients from the angiotensin-converting enzyme inhibitor group (mean: 105 ± 19%) and the angiotensin-II receptor blocker group (mean: 105.1 ± 18.73%) showed higher predicted values of muscle strength than control group patients (mean: 98.15 ± 18.77%). [Conclusion] Older adults using angiotensin-converting enzyme inhibitors or angiotensin-II receptor blockers have better functional exercise capacity and muscle strength.
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil.
authors.forename: Vinícius A
authors.initials: VA
authors.lastname: Coelho
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil.
authors.forename: Vanessa S
authors.initials: VS
authors.lastname: Probst
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil.
authors.forename: Bruna M
authors.initials: BM
authors.lastname: Nogari
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil; Department of Physical Education, State University of Londrina (UEL), Brazil.
authors.forename: Denilson C
authors.initials: DC
authors.lastname: Teixeira
authors.affiliation: Doctoral Program in Health Sciences, State University of Londrina (UEL), Brazil.
authors.forename: Josiane M
authors.initials: JM
authors.lastname: Felcar
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil.
authors.forename: Denis C
authors.initials: DC
authors.lastname: Santos
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil.
authors.forename: Marcus Vinícius M
authors.initials: MV
authors.lastname: Gomes
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil.
authors.forename: Rodrigo A C
authors.initials: RA
authors.lastname: Andraus
authors.affiliation: Health Sciences Research Center, University of Northern Parana (UNOPAR), Brazil; School of Medicine, Pontificial Catholic University of Paraná (PUCPR), Brazil.
authors.forename: Karen B P
authors.initials: KB
authors.lastname: Fernandes
keywords: Ageing; Exercise capacity; Muscle strength