title: [Outcomes of Tertiary Debulking Surgery(TDS)for Re-Recurrent Ovarian Cancer].
abstract: The survival of patients with recurrent ovarian cancer who have completed secondary debulking surgery (SDS) has been shown to increase. However, whether tertiary debulking surgery (TDS) aimed at complete surgery is useful in patients with a second recurrence is unclear. Eight patients who had undergone SDS were treated after a second recurrence in our hospital. Their medical records were retrospectively reviewed. Consequently, TDS was performed in 4 of the patients (TDSgr). All 4 patients underwent complete debulking surgery, 2 patients received blood transfusions, and none had serious postoperative complications. The median treatment free interval (TFI) from recurrence surgery to the second recurrence was 16 months (range, 9-23 months), and the median TFI after the second recurrence was 30.5 months (range, 15-69 months). Meanwhile, the median TFI after the second recurrence was 7.5 months (range, 1-31 months) in the 4 patients who did not undergo TDS (non-TDSgr). The median survival times after the second recurrence in TDSgr and non-TDSgr were 53 months (range, 41-69 months) and 12 months (range, 2-30 months), respectively. When complete surgery is indicated in patients with a second recurrent ovarian cancer after SDS, in case of good physical condition with single or multiple recurrent lesions, TDS may increase survival and TFI.
authors.affiliation: Dept. of Gynecologic Oncology, National Hospital Organization Shikoku Cancer Center.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kusumoto
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Konishi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Okame
authors.forename: Masaaki
authors.initials: M
authors.lastname: Komatsu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shiroyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takehara
mesh_terms: D000328:Adult; D000368:Aged; D065426:Cytoreduction Surgical Procedures; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome