title: [Levels of proinflammatory cytokines and vascular endothelial growth factor in patients with Alzheimer's disease and mild cognitive impairment].
abstract: OBJECTIVE
  to evaluate the levels of cytokines (IFNα, IFNγ, IL-2, Il-4, IL-6, IL-8, IL-10, IL-12, IL-15), IL-1β receptor antagonist (IL-1RA), vascular endothelial growth factor (VEGF) and its antagonist, the soluble form of receptor 1 (sVEGFR1) in the blood serum of patients with Alzheimer's disease, with early onset (ADEO) and late onset (ADLO), and in patients with mild cognitive impairment (MCI).
  
  
  METHODS
  Levels of interleukins, IL-1RA, VEGF and sVEGFR1 were measured in 20 patients with AD and 11 patients with MCI using ELISA. These parameters were compared to the severity of cognitive impairment assessed by the performance on neurocognitive tests.
  
  
  CONCLUSIONS
  The levels of key cytokines (IL-8, TNFα, IL-12), VEGF and sVEGFR1 as well as anti-inflammatory proteins were different in patients with ADEO, ADLO and MCI. These differences suggest the phenotypic and genotypic heterogeneity of the disease that demands further research.
authors.affiliation: National Research Center 'Kurchatov Institute', Moscow.
authors.forename: I K
authors.initials: IK
authors.lastname: Malashenkova
authors.affiliation: National Research Center 'Kurchatov Institute', Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Hailov
authors.affiliation: National Research Center 'Kurchatov Institute', Moscow.
authors.forename: S A
authors.initials: SA
authors.lastname: Krynskiy
authors.affiliation: Research Institute of physical-chemical medicine, Moscow.
authors.forename: D P
authors.initials: DP
authors.lastname: Ogurtsov
authors.affiliation: National Research Center 'Kurchatov Institute', Moscow.
authors.forename: G V
authors.initials: GV
authors.lastname: Kazanova
authors.affiliation: National Research Center 'Kurchatov Institute', Moscow.
authors.forename: B B
authors.initials: BB
authors.lastname: Velichkovckiy
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: N D
authors.initials: ND
authors.lastname: Selezneva
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: Ya B
authors.initials: YB
authors.lastname: Fedorova
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Ponomareva
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: I V
authors.initials: IV
authors.lastname: Kolyhalov
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: S I
authors.initials: SI
authors.lastname: Gavrilova
authors.affiliation: Research Institute of physical-chemical medicine, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Didkovsky
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000150:complications; D060825:Cognitive Dysfunction / Q000097:blood* / Q000150:complications; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D016207:Cytokines; D042461:Vascular Endothelial Growth Factor A