title: The role of miRNAs and epigenetic mechanisms in primary gastric mucosa-associated lymphoid tissue lymphoma.
abstract: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a rare low-grade B-cell non-Hodgkin lymphoma associated with Helicobacter pylori infection and the subsequent chronic inflammation. Significant progress in understanding the pathogenesis of the disease has already been made. However, the exact molecular pathways of lymphomagenesis remain unclear. Furthermore, difficulties regarding accurate diagnosis of gastric MALT lymphoma and its discrimination from gastritis or other lymphoma subtypes arise. Recent studies evaluate the role of miRNAs and epigenetic alterations on MALT lymphoma pathogenesis and prognosis. This review critically summarizes the most important data on the role of miRNAs and epigenetics in MALT lymphomas pathogenesis, prognosis and treatment.
authors.affiliation: Second Department of Internal Medicine & Research Institute, 'Attikon' University General Hospital, Medical School, University of Athens, Haidari, Greece.
authors.forename: Diamantina
authors.initials: D
authors.lastname: Vasilatou
authors.affiliation: Second Department of Internal Medicine & Research Institute, 'Attikon' University General Hospital, Medical School, University of Athens, Haidari, Greece.
authors.forename: Athanasios D
authors.initials: AD
authors.lastname: Sioulas
authors.affiliation: Second Department of Internal Medicine & Research Institute, 'Attikon' University General Hospital, Medical School, University of Athens, Haidari, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Pappa
authors.affiliation: Second Department of Internal Medicine & Research Institute, 'Attikon' University General Hospital, Medical School, University of Athens, Haidari, Greece.
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Papanikolaou
authors.affiliation: Second Department of Internal Medicine & Research Institute, 'Attikon' University General Hospital, Medical School, University of Athens, Haidari, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Triantafyllou
authors.affiliation: Second Department of Internal Medicine & Research Institute, 'Attikon' University General Hospital, Medical School, University of Athens, Haidari, Greece.
authors.forename: George D
authors.initials: GD
authors.lastname: Dimitriadis
authors.affiliation: Second Department of Internal Medicine & Research Institute, 'Attikon' University General Hospital, Medical School, University of Athens, Haidari, Greece.
authors.forename: Sotirios G
authors.initials: SG
authors.lastname: Papageorgiou
mesh_terms: D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: MALT; epigenetics; miRNAs