title: The Human Vaccines Project: A roadmap for cancer vaccine development.
abstract: Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited by most vaccines tested, but their clinical efficacy remains modest. We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.
authors.affiliation: Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.
authors.forename: Pedro
authors.initials: P
authors.lastname: Romero
authors.affiliation: The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Nina
authors.initials: N
authors.lastname: Bhardwaj
authors.affiliation: Bristol-Myers Squibb, Wallingford, CT06492, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Cockett
authors.affiliation: University of Washington School of Medicine, Seattle, WA 98109-4714, USA.
authors.forename: Mary L
authors.initials: ML
authors.lastname: Disis
authors.affiliation: Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
authors.forename: Glenn
authors.initials: G
authors.lastname: Dranoff
authors.affiliation: Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
authors.forename: Eli
authors.initials: E
authors.lastname: Gilboa
authors.affiliation: MedImmune, Gaithersburg, MD 20878, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Hammond
authors.affiliation: Celgene Immuno-Oncology Center of Excellence, 1616 Eastlake Avenue, Suite 500, Seattle, WA 98102, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Hershberg
authors.affiliation: Bristol-Myers Squibb, Biologics Discovery California, Redwood City, CA 94063, USA.
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Korman
authors.affiliation: Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.
authors.forename: Pia
authors.initials: P
authors.lastname: Kvistborg
authors.affiliation: ISA Pharmaceuticals & Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
authors.forename: Cornelis
authors.initials: C
authors.lastname: Melief
authors.affiliation: Genentech, San Francisco, CA 94080, USA.
authors.forename: Ira
authors.initials: I
authors.lastname: Mellman
authors.affiliation: The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
authors.forename: A Karolina
authors.initials: AK
authors.lastname: Palucka
authors.affiliation: Oxford University, Oxford OX3 7DQ, UK.
authors.forename: Irina
authors.initials: I
authors.lastname: Redchenko
authors.affiliation: Adaptive Biotechnologies, Fred Hutchinson Cancer Research Center, Seattle, WA 98102, USA.
authors.forename: Harlan
authors.initials: H
authors.lastname: Robins
authors.affiliation: Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
authors.forename: Federica
authors.initials: F
authors.lastname: Sallusto
authors.affiliation: West Monument Consulting, 1906 R Street NW Street 11, Washington, DC 20009, USA.
authors.forename: Theodore
authors.initials: T
authors.lastname: Schenkelberg
authors.affiliation: Center for Personalized Cancer Immunotherapy, La Jolla Institute for Allergy and Immunology & UCSD Moores Cancer Center, La Jolla, San Diego, CA 92037, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Schoenberger
authors.affiliation: Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Sosman
authors.affiliation: CI3 Cluster for Individualized Immunotherapy, Kupferbergterasse 17-19, 55131 Mainz, Germany.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Türeci
authors.affiliation: Ludwig Institute for Cancer Research, Brussels branch, Brussels, BRU 1200, Belgium. Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium. University of Oxford, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
authors.forename: Benoît
authors.initials: B
authors.lastname: Van den Eynde
authors.affiliation: International AIDS Vaccines Initiative, 125 Broad Street, 9th Floor, New York, NY 10004, USA.
authors.forename: Wayne
authors.initials: W
authors.lastname: Koff
authors.affiliation: Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland. george.coukos@chuv.ch.
authors.forename: George
authors.initials: G
authors.lastname: Coukos
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines