title: The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders.
abstract: There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins could prevent AD. We compared the literature on MDBs and AD pathogenesis, which include roles played by p62, ubiquitin UBB +1, HSPs70, 90, 104, FAT10, NEDD8, VCP/97, and the protein quality control mechanisms including the 26s proteasome, the IPOD and JUNQ and autophagosome pathways.
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, United States.
authors.forename: S W
authors.initials: SW
authors.lastname: French
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, United States.
authors.forename: A S
authors.initials: AS
authors.lastname: Mendoza
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, United States.
authors.forename: Y
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D000071182:Autophagosomes / Q000378:metabolism; D006801:Humans; D059609:Mallory Bodies / Q000378:metabolism*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D066329:Protein Aggregates; D066263:Protein Aggregation, Pathological / Q000378:metabolism*
chemical_list: D066329:Protein Aggregates; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease
keywords: 26S proteasome; Neurofibrillary tangles (NFT); Protein quality control; β amyloid (Aβ)