title: Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System.
abstract: The colony-stimulating factor-1 receptor (CSF-1R) kinase regulates tissue macrophage homeostasis, osteoclastogenesis, and Paneth cell development. However, recent studies in mice have revealed that CSF-1R signaling directly controls the development and maintenance of microglia, and cell autonomously regulates neuronal differentiation and survival. While the CSF-1R-cognate ligands, CSF-1 and interleukin-34 (IL-34) compete for binding to the CSF-1R, they are expressed in a largely non-overlapping manner by mature neurons. The recent identification of a dominantly inherited, adult-onset, progressive dementia associated with inactivating mutations in the CSF-1R highlights the importance of CSF-1R signaling in the brain. We review the roles of the CSF-1R and its ligands in microglial and neural development and function, and their relevance to our understanding of neurodegenerative disease.
authors.affiliation: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Violeta
authors.initials: V
authors.lastname: Chitu
authors.affiliation: Institute for Brain Disorders and Neural Regeneration, Departments of Neurology, Neuroscience, and Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Şölen
authors.initials: Ş
authors.lastname: Gokhan
authors.affiliation: Departments of Neuroscience and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Sayan
authors.initials: S
authors.lastname: Nandi
authors.affiliation: Institute for Brain Disorders and Neural Regeneration, Departments of Neurology, Neuroscience, and Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Mehler
authors.affiliation: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: richard.stanley@einstein.yu.edu.
authors.forename: E Richard
authors.initials: ER
authors.lastname: Stanley
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D017628:Microglia / Q000378:metabolism*; D010766:Phosphorylation; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000378:metabolism*
chemical_list: D008024:Ligands; D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor
keywords: IL-34; adult-onset leukoencephalopathy with axonal spheroids and pigmented glia; microglia; neural development; neurodegenerative disease; neuronal survival