title: Developing imidazoles as CEST MRI pH sensors.
abstract: A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N-H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Xing
authors.initials: X
authors.lastname: Yang
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.|F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Song
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Ray Banerjee
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.|F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Pharmacy, Korea University, Sejong, South Korea.
authors.forename: Youngjoo
authors.initials: Y
authors.lastname: Byun
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.|F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
authors.forename: Guanshu
authors.initials: G
authors.lastname: Liu
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Zaver M
authors.initials: ZM
authors.lastname: Bhujwalla
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Martin G
authors.initials: MG
authors.lastname: Pomper
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.|F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: McMahon
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000032:analysis*; D007668:Kidney / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice
chemical_list: D003287:Contrast Media; D007093:Imidazoles
keywords: chemical exchange saturation transfer; imidazole-4,5-dicarboxamides; molecular imaging; pH imaging