title: Endophthalmitis related to lemon allergy in a heroin addict.
abstract: BACKGROUND
  Heroin and its contaminants may be an important source of allergens in young people. We present a case of severe endophthalmitis in a patient that also suffered from anaphylactoid symptoms (hypotension, urticaria, glottic oedema) whenever he ingested lemon.
  
  
  METHODS
  Prick tests with a battery of 42 aeroallergens including fruits and citrus fruits (orange, mandarin, grapefruit and lemon) and specific IgE to these allergens were carried out. Immunodetection was performed using the patient's serum and the following allergens: lemon, Candida, Aspergillus, Penicillium and Alternaria recombinant Alt 1 (Laboratories Diater).
  
  
  RESULTS
  Skin tests were negative for Candida, Penicillium, Aspergillus and Cladosporium (ALK-Spain) as were specific IgE antibodies for CAP (Thermofisher, Sweden) and positive only for lemon and, doubtfully, to Candida. Specific IgE tests to pollen, arthropods, fungi, dander and foods were positive only for lemon (0.49kU/L). Serological study of fungi ruled out fungal infection at that time. The immunodetection showed that the patient's serum recognised a protein of approximately 25kDa of lemon peel, one of approximately 12-13kDa of Penicillium, and perfectly recognised Alt a 1.
  
  
  CONCLUSIONS
  Lemon surface can be contaminated by Candida and other fungi. In heroin addicts with positive skin tests for lemon, the possibility of these serious complications should be taken into account.
authors.affiliation: Allergy Unit, Rio Hortega University Hospital, Valladolid, Spain. Electronic address: aliciaarmentia@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Armentia
authors.affiliation: DIATER Laboratories, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Pineda
authors.affiliation: Allergy Unit, Rio Hortega University Hospital, Valladolid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Martin-Armentia
authors.affiliation: Immunology, Microbiology and Parasitology Department, Rio Hortega University Hospital, Valladolid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Ramos
authors.affiliation: Immunology, Microbiology and Parasitology Department, Rio Hortega University Hospital, Valladolid, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Gil Martin
authors.affiliation: DIATER Laboratories, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Palacios
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D000707:Anaphylaxis / Q000175:diagnosis* / Q000209:etiology; D052179:Antigens, Plant / Q000276:immunology*; D002957:Citrus / Q000276:immunology; D009877:Endophthalmitis / Q000175:diagnosis* / Q000209:etiology; D005512:Food Hypersensitivity / Q000150:complications / Q000175:diagnosis*; D000067030:Fruit and Vegetable Juices / Q000009:adverse effects; D003932:Heroin / Q000276:immunology*; D006556:Heroin Dependence / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D012882:Skin Tests; D013030:Spain
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D007073:Immunoglobulin E; D003932:Heroin
keywords: Aspergillus; Candida; Cladosporium; Endophthalmitis; Heroin allergy; Lemon allergy; Opioids allergy; Penicillium