title: Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma.
abstract: OBJECTIVE
  Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have been reported, but a lot of patients probably elude proper diagnosis because of both variability of symptoms and ignorance of this syndrome by many physicians. The pathogenesis remains unclear, and could involve functional lymphatic abnormalities, microvasculopathy or lymphocyte deficiency, but none of these hypotheses seems fully satisfactory.
  
  
  METHODS
  We report for the first time two cases of YNS associated with multiple myeloma relapsing after non-myeloablative haematopoietic cell transplantation (HCT). In these two cases, onset or worsening of YNS symptoms followed graft-versus-host disease (GvHD) manifestations.
  
  
  METHODS
  Corticosteroids given to treat GvHD also improved YNS manifestations.
  
  
  CONCLUSIONS
  YNS after HCT might be a microvascular manifestation of endothelial GvHD and corticosteroids might be an effective treatment.
authors.affiliation: a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Céline
authors.initials: C
authors.lastname: Gregoire
authors.affiliation: b Department of Medicine, Division of Pneumology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Julien
authors.initials: J
authors.lastname: Guiot
authors.affiliation: a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Vertenoeil
authors.affiliation: a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Évelyne
authors.initials: É
authors.lastname: Willems
authors.affiliation: a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Kaoutar
authors.initials: K
authors.lastname: Hafraoui
authors.affiliation: b Department of Medicine, Division of Pneumology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Corhay
authors.affiliation: b Department of Medicine, Division of Pneumology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Renaud
authors.initials: R
authors.lastname: Louis
authors.affiliation: a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Beguin
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000601:surgery*; D056684:Yellow Nail Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D005938:Glucocorticoids
keywords: Allogeneic haematopoietic cell transplantation; Graft-versus-host-disease; Multiple myeloma; Yellow nail syndrome