title: Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth.
abstract: Thyroid dysfunction in adolescents treated with minocycline for acne has been previously described as transient effect and/or associated with autoimmune thyroiditis. We report nonimmune-mediated thyroid dysfunction associated with minocycline/doxycycline in 3 adolescents whose clinical courses suggest an adverse effect that may be more common, serious, and persistent than realized previously.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address: apollock@pediatrics.wisc.edu.
authors.forename: Allison J
authors.initials: AJ
authors.lastname: Pollock
authors.affiliation: Case Western Reserve University School of Medicine, Cleveland, OH.
authors.forename: Tasa
authors.initials: T
authors.lastname: Seibert
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors.forename: David B
authors.initials: DB
authors.lastname: Allen
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004172:Diplopia / Q000209:etiology; D005221:Fatigue / Q000209:etiology; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D059606:Polydipsia / Q000209:etiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D015431:Weight Loss
chemical_list: D000900:Anti-Bacterial Agents; D013972:Thyrotropin; D008911:Minocycline; D013974:Thyroxine
keywords: acne vulgaris; doxycycline; hyperthyroidism; hypothyroidism; minocycline; tetracycline; thyroid dysfunction; thyroiditis