title: Is there a common pathogenesis in aggressive periodontitis & ankylosing spondylitis in HLA-B27 patient?
abstract: HLA-B27 is having strong association to ankylosing spondylitis (AS) and other inflammatory diseases collectively known as seronegative spondyloarthropathy. In literature, although the evidence for association between AS and periodontitis as well as AS and HLA-B27 are there but the association of aggressive periodontitis in HLA-B27 positive patient with AS are not there. We hypothesize that there may be a common pathogenesis in aggressive periodontitis and ankylosing spondylitis in HLA-B27 patient. A 27-years-old female presented with the features of generalized aggressive periodontitis and difficulty in walking. On complete medical examination, ankylosing spondylitis was diagnosed with further positive HLA-B27 phenotype and negative rheumatic factor. This report may open up a new link to explore in the pathogenesis of aggressive periodontitis.
authors.affiliation: Department of Periodontology, People's Dental Academy, Bhopal, India. Electronic address: dna7kgmc@gmail.com.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Agrawal
authors.affiliation: Department of Oral Medicine & Radiology, People's College of Dental Sciences, Bhopal, India.
authors.forename: Kavita
authors.initials: K
authors.lastname: Agarwal
authors.affiliation: Department of Orthopedics, People's College of Medical Sciences, Bhopal, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Varshney
authors.affiliation: Department of Pedodontics, Rau Institute of Dental Sciences, Indore, India.
authors.forename: Navneet
authors.initials: N
authors.lastname: Agrawal
authors.affiliation: Department of Periodontology, People's Dental Academy, Bhopal, India.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dubey
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics / Q000276:immunology; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D007249:Inflammation; D008954:Models, Biological; D010641:Phenotype; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen