title: Glycoholics Anonymous: Cancer Sobers Up with mTORC1.
abstract: In this issue of Cancer Cell, Pusapati et al. (2016) reveal that mTORC1 orchestrates the metabolic reprogramming of cancer cells in response to glycolytic inhibitors, bypassing glycolysis by increasing glutamine uptake and pentose phosphate flux to generate energy and biomass.
authors.affiliation: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Vivian
authors.initials: V
authors.lastname: Fu
authors.affiliation: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Moroishi
authors.affiliation: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: kuguan@ucsd.edu.
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan
mesh_terms: D005947:Glucose / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D009369:Neoplasms; D010427:Pentose Phosphate Pathway
chemical_list: D005973:Glutamine; D005947:Glucose