title: Hsp90 Inhibitors in Parasitic Nematodes: Prospects and Challenges.
abstract: Hsp90 inhibitors are well characterized in relation to their effects in a variety of tumors, with several inhibitors in various phases of clinical development. In recent years, the same inhibitor classes have been tested for efficacy in other systems, such as Alzheimer's disease and a variety of infectious disease models, including fungal and parasitic targets. In this article we discuss the repurposing of Hsp90 inhibitors for parasitic disease with a focus on parasitic nematode infections. We summarize the data that indicate that Hsp90 is functionally diverse in different nematode species and we discuss the challenges and prospects for developing these inhibitors as next generation chemotherapeutic tools.
authors.affiliation: Institute of Biodiversity, Comparative Medicine and Animal Health, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow G61 1QH, UK. eileen.devaney@glasgow.ac.uk.
authors.forename: Eileen
authors.initials: E
authors.lastname: Devaney
authors.forename: Victoria
authors.initials: V
authors.lastname: Gillan
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009348:Nematoda / Q000187:drug effects* / Q000378:metabolism; D009349:Nematode Infections / Q000188:drug therapy
chemical_list: D000977:Antiparasitic Agents; D018841:HSP90 Heat-Shock Proteins