title: Children with chronic lung diseases have cognitive dysfunction as assessed by event-related potential (auditory P300) and Stanford-Binet IQ (SB-IV) test.
abstract: Chronic lung disease (CLD) in children represents a heterogeneous group of many clinico-pathological entities with risk of adverse impact of chronic or intermittent hypoxia. So far, few researchers have investigated the cognitive function in these children, and the role of auditory P300 in the assessment of their cognitive function has not been investigated yet. This study was designed to assess the cognitive functions among schoolchildren with different chronic pulmonary diseases using both auditory P300 and Stanford-Binet test. This cross-sectional study included 40 school-aged children who were suffering from chronic chest troubles other than asthma and 30 healthy children of similar age, gender and socioeconomic state as a control group. All subjects were evaluated through clinical examination, radiological evaluation and spirometry. Audiological evaluation included (basic otological examination, pure-tone, speech audiometry and immittancemetry). Cognitive function was assessed by auditory P300 and psychological evaluation using Stanford-Binet test (4th edition). Children with chronic lung diseases had significantly lower anthropometric measures compared to healthy controls. They had statistically significant lower IQ scores and delayed P300 latencies denoting lower cognitive abilities. Cognitive dysfunction correlated to severity of disease. P300 latencies were prolonged among hypoxic patients. Cognitive deficits in children with different chronic lung diseases were best detected using both Stanford-Binet test and auditory P300. P300 is an easy objective tool. P300 is affected early with hypoxia and could alarm subtle cognitive dysfunction.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Terez2003@hotmail.com.
authors.forename: Terez Boshra
authors.initials: TB
authors.lastname: Kamel
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Mahmoud Tarek
authors.initials: MT
authors.lastname: Abd Elmonaem
authors.affiliation: Audiology Unit, Department of Otolaryngology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Lobna Hamed
authors.initials: LH
authors.lastname: Khalil
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Mona Hamdy
authors.initials: MH
authors.lastname: Goda
authors.affiliation: Audiology Unit, Department of Otolaryngology, Menoufia University, Menoufia, Egypt.
authors.forename: Hossam
authors.initials: H
authors.lastname: Sanyelbhaa
authors.affiliation: Department of Pediatrics, El-Galaa Military Hospitals, Cairo, Egypt.
authors.forename: Mourad Alfy
authors.initials: MA
authors.lastname: Ramzy
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology*; D003430:Cross-Sectional Studies; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000523:psychology*; D008297:Male; D011594:Psychometrics
keywords: Chronic lung diseases; Hypoxia; P300; Stanford–Binet