title: Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults.
abstract: Liver-related mortality is the third cause of death in patients with nonalcoholic fatty liver disease, but the long-term prognosis basically depends on the presence and severity of liver damage. Thus, life expectancy in patients with simple steatosis is not different from the general population, but liver-related mortality is significantly higher in patients with nonalcoholic steatohepatitis (NASH), particularly in those with advanced fibrosis. Progression of liver disease is observed in up to one-third of patients with NASH. The long-term hepatic prognosis mostly depends on the histologic stage at initial liver biopsy, but multiple risk factors may concur.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, Corso Bramante 88, Turin I-10126, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Marengo
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, Corso Bramante 88, Turin I-10126, Italy.
authors.forename: Ramy Ibrahim Kamal
authors.initials: RI
authors.lastname: Jouness
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, Corso Bramante 88, Turin I-10126, Italy. Electronic address: elisabetta.bugianesi@unito.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bugianesi
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000209:etiology; D018450:Disease Progression; D006801:Humans; D056865:Ideal Body Weight; D015994:Incidence; D008103:Liver Cirrhosis / Q000453:epidemiology* / Q000209:etiology; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000209:etiology; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D012307:Risk Factors
keywords: Cirrhosis; Hepatocellular carcinoma; Obesity; Steatohepatitis; Type 2 diabetes