title: Impact of Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae on Reporting and Prescribing.
abstract: The CLSI cefepime breakpoints were revised to include a susceptible-dose-dependent (SDD) category for Enterobacteriaceae, with the intention that higher cefepime doses be used for these isolates. In this study, 1.6% of Enterobacteriaceae isolates were reported as SDD, with Escherichia coli the most common SDD organism. Cefepime was prescribed in three cases (4.8%); the majority of SDD isolates were treated with a carbapenem. Enterobacteriaceae with cefepime SDD MICs were not commonly treated with cefepime at our institution.
authors.affiliation: Hospital Pharmacy Services, Mayo Clinic, Rochester, Minnesota, USA rivera.christina@mayo.edu.
authors.forename: Christina G
authors.initials: CG
authors.lastname: Rivera
authors.affiliation: Hospital Pharmacy Services, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Prasanna P
authors.initials: PP
authors.lastname: Narayanan
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
authors.affiliation: Hospital Pharmacy Services, Mayo Clinic, Rochester, Minnesota, USA Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Lynn L
authors.initials: LL
authors.lastname: Estes
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use; D000077723:Cefepime; D002511:Cephalosporins / Q000627:therapeutic use*; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000254:growth & development; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; D000077723:Cefepime