title: Alphavirus-Based Vaccines.
abstract: Alphavirus vectors based on Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been widely applied for vaccine development. Naked RNA replicons, recombinant viral particles, and layered DNA vectors have been subjected to immunization in preclinical animal models with antigens for viral targets and tumor antigens. Moreover, a limited number of clinical trials have been conducted in humans. Vaccination with alphavirus vectors has demonstrated efficient immune responses and has showed protection against challenges with lethal doses of virus and tumor cells, respectively. Moreover, vaccines have been developed against alphaviruses causing epidemics such as Chikungunya virus.
authors.affiliation: PanTherapeutics, Rue des Remparts 4, CH1095, Lutry, Switzerland. lundstromkenneth@gmail.com.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lundstrom
mesh_terms: D000524:Alphavirus / Q000235:genetics*; D000818:Animals; D015153:Blotting, Western; D002272:Carcinoembryonic Antigen / Q000235:genetics; D002846:Chromatography, Affinity; D003001:Cloning, Molecular; D004274:DNA, Recombinant / Q000235:genetics; D018274:Electroporation; D005455:Fluorescent Antibody Technique; D005818:Genetic Engineering / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000235:genetics; D007114:Immunization; D008251:Macaca; D051379:Mice; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D014158:Transcription, Genetic; D014461:Ultracentrifugation; D014612:Vaccines / Q000235:genetics* / Q000276:immunology
chemical_list: D002272:Carcinoembryonic Antigen; D004274:DNA, Recombinant; D012367:RNA, Viral; D014612:Vaccines; D049452:Green Fluorescent Proteins
keywords: Alphaviruses; Cancer vaccines; Immunization; Protection; Viral vaccines