title: Hyperemesis gravidarum and its relation with maternal body fat composition.
abstract: The objective of this study was to determine if maternal body fat composition and body mass index were associated with hyperemesis gravidarum (HG) in the first trimester of pregnancy. Healthy pregnant women (n = 30) without nausea and vomiting (control group) and women with HG (n = 54; study group), all with singleton pregnancy at 6-14 weeks gestational age, were included. Body mass index was measured before and during pregnancy. Visceral adipose tissue (VAT) and subcutaneous fat thickness were measured during pregnancy. Comparison of the groups revealed that VAT and pre-pregnancy body mass index but not subcutaneous fat thickness were significantly higher in the HG group versus controls. VAT and pre-pregnancy body mass index predicted 83.8% and 67.1% of HG cases, respectively. VAT and pre-pregnancy body mass index were correlated with the development of hyperemesis gravidrum and hence could be considered as predictive markers for HG.
authors.affiliation: a Department of Obstetrics and Gynecology , Turgut Ozal University Hospital , Ankara , Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Kosus
authors.affiliation: a Department of Obstetrics and Gynecology , Turgut Ozal University Hospital , Ankara , Turkey.
authors.forename: Ayla
authors.initials: A
authors.lastname: Eser
authors.affiliation: a Department of Obstetrics and Gynecology , Turgut Ozal University Hospital , Ankara , Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Kosus
authors.affiliation: b Department of Obstetrics and Gynecology , Cengiz Gökçek State Hospital , Gaziantep , Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Usluogullari
authors.affiliation: a Department of Obstetrics and Gynecology , Turgut Ozal University Hospital , Ankara , Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Hizli
mesh_terms: D000328:Adult; D050218:Body Fat Distribution / Q000009:adverse effects*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000209:etiology*; D050152:Intra-Abdominal Fat / Q000473:pathology; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000502:physiology*; D012307:Risk Factors; D012885:Skinfold Thickness; D050151:Subcutaneous Fat / Q000473:pathology; D055815:Young Adult
keywords: Hyperemesis gravidarum; body mass index; subcutaneous fat thickness; visceral adipose tissue