title: 31P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a Predictor of Gait Speed in the Baltimore Longitudinal Study of Aging.
abstract: Aerobic fitness and muscle bioenergetic capacity decline with age; whether such declines explain age-related slowing of walking speed is unclear. We hypothesized that muscle energetics and aerobic capacity are independent correlates of walking speed in simple and challenging performance tests and that they account for the observed age-related decline in walking speed in these same tests.
  
  
  
  Muscle bioenergetics was assessed as postexercise recovery rate of phosphocreatine (PCr), kPCr, using phosphorus magnetic resonance spectroscopy (31P-MRS) in 126 participants (53 men) of the Baltimore Longitudinal Study of Aging aged 26-91 years (mean = 72 years). Four walking tasks were administered-usual pace over 6 m and 150 seconds and fast pace over 6 m and 400 m. Separately, aerobic fitness was assessed as peak oxygen consumption (peak VO2) using a graded treadmill test.
  
  
  
  All gait speeds, kPCr, and peak VO2were lower with older age. Independent of age, sex, height, and weight, both kPCrand peak VO2were positively and significantly associated with fast pace and long distance walking but only peak VO2and not kPCrwas significantly associated with usual gait speed over 6 m. Both kPCrand peak VO2substantially attenuated the association between age and gait speed for all but the least stressful walking task of 6 m at usual pace.
  
  
  
  Muscle bioenergetics assessed using31P-MRS is highly correlated with walking speed and partially explains age-related poorer performance in fast and long walking tasks.
authors.affiliation: Translational Gerontology Branch and.
authors.forename: Seongjin
authors.initials: S
authors.lastname: Choi
authors.affiliation: Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: David A
authors.initials: DA
authors.lastname: Reiter
authors.affiliation: Translational Gerontology Branch and.
authors.forename: Michelle
authors.initials: M
authors.lastname: Shardell
authors.affiliation: Translational Gerontology Branch and.
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Simonsick
authors.affiliation: Translational Gerontology Branch and.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Studenski
authors.affiliation: Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Spencer
authors.affiliation: Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Fishbein
authors.affiliation: Translational Gerontology Branch and ferruccilu@mail.nih.gov.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015142:Baltimore; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008137:Longitudinal Studies; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000378:metabolism*; D000072797:Walking Speed
chemical_list: D010725:Phosphocreatine
keywords: Bioenergetics; Lower extremity performance; Magnetic resonance spectroscopy; Muscle; Walking speed