title: Nanotexaphyrin: One-Pot Synthesis of a Manganese Texaphyrin-Phospholipid Nanoparticle for Magnetic Resonance Imaging.
abstract: The discovery and synthesis of novel multifunctional organic building blocks for nanoparticles is challenging. Texaphyrin macrocycles are capable and multifunctional chelators. However, they remain elusive as building blocks for nanoparticles because of the difficulty associated with synthesis of texaphyrin constructs capable of self-assembly. A novel manganese (Mn)-texaphyrin-phospholipid building block is described, along with its one-pot synthesis and self-assembly into a Mn-nanotexaphyrin. This nanoparticle possesses strong resilience to manganese dissociation, structural stability, in vivo bio-safety, and structure-dependent T1 and T2 relaxivities. Magnetic resonance imaging (MRI) contrast enhanced visualization of lymphatic drainage is demonstrated with respect to proximal lymph nodes on the head and neck VX-2 tumors of a rabbit. Synthesis of 17 additional metallo-texaphyrin building blocks suggests that this novel one-pot synthetic procedure for nanotexaphyrins may lead to a wide range of applications in the field of nanomedicines.
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.|Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Canada.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Keca
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada.|Department of Medical Biophysics, University of Toronto, Canada.
authors.forename: Marta
authors.initials: M
authors.lastname: Overchuk
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.
authors.forename: Nidal
authors.initials: N
authors.lastname: Muhanna
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.
authors.forename: Christina M
authors.initials: CM
authors.lastname: MacLaughlin
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.
authors.forename: Cheng S
authors.initials: CS
authors.lastname: Jin
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.
authors.forename: Warren D
authors.initials: WD
authors.lastname: Foltz
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Irish
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Canada. gang.zheng@uhnres.utoronto.ca.|Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Canada. gang.zheng@uhnres.utoronto.ca.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada. gang.zheng@uhnres.utoronto.ca.|Department of Medical Biophysics, University of Toronto, Canada. gang.zheng@uhnres.utoronto.ca.
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
keywords: magnetic resonance imaging; metal chelation; nano-assembly; nanoparticles; texaphyrin