title: Targeting Iron Homeostasis in Acute Kidney Injury.
abstract: Iron is an essential metal involved in several major cellular processes required to maintain life. Because of iron's ability to cause oxidative damage, its transport, metabolism, and storage is strictly controlled in the body, especially in the small intestine, liver, and kidney. Iron plays a major role in acute kidney injury and has been a target for therapeutic intervention. However, the therapies that have been effective in animal models of acute kidney injury have not been successful in human beings. Targeting iron trafficking via ferritin, ferroportin, or hepcidin may offer new insights. This review focuses on the biology of iron, particularly in the kidney, and its implications in acute kidney injury.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Vyvyca J
authors.initials: VJ
authors.lastname: Walker
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL; Birmingham Veterans Administration Medical Center, Birmingham, AL. Electronic address: agarwal@uab.edu.
authors.forename: Anupam
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000378:metabolism*; D005293:Ferritins / Q000097:blood*; D064451:Hepcidins / Q000627:therapeutic use*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000378:metabolism*
chemical_list: D064451:Hepcidins; D005293:Ferritins; D007501:Iron
keywords: Iron; ferritin; ferroportin; hepcidin; injury; kidney