title: Can the preterm lung recover from perinatal stress?
abstract: After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and gas exchange but also interfere with fetal and neonatal lung development. Prenatal insults like chorioamnionitis and prenatal interventions like maternal glucocorticosteroids interact but might also determine the preterm baby's lung response to postnatal interventions ("second hit") like supplementation of oxygen and drug therapy. We review current experimental and clinical findings on the influence of different perinatal factors on preterm lung development and discuss how well-established interventions in neonatal care might be adapted to attenuate postnatal lung injury.
authors.affiliation: Neonatology, Department of Pediatrics, Maastricht University Medical Center, Maastricht, Netherlands.|Neonatology, Department of Pediatrics, Aachen University Hospital, Aachen, Germany.|Neonatology, Department of Pediatrics, Würzburg University Hospital, Würzburg, Germany.|Faculty of Health, Medicine and Lifesciences, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Hütten
authors.affiliation: Neonatology, Department of Pediatrics, Maastricht University Medical Center, Maastricht, Netherlands.|Faculty of Health, Medicine and Lifesciences, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
authors.forename: Tim G A M
authors.initials: TG
authors.lastname: Wolfs
authors.affiliation: Neonatology, Department of Pediatrics, Maastricht University Medical Center, Maastricht, Netherlands. b.kramer@maastrichtuniversity.nl.|Faculty of Health, Medicine and Lifesciences, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. b.kramer@maastrichtuniversity.nl.
authors.forename: Boris W
authors.initials: BW
authors.lastname: Kramer
keywords: Bronchopulmonary dysplasia; Caffeine; Chorioamnionitis; Glucocorticosteroids; Lung injury; Oxygen toxicity; Ventilation; Vitamin A