title: VEGF-B Improves Metabolic Health through Vascular Pruning of Fat.
abstract: Unraveling the mechanism VEGF-receptors modulating metabolism has therapeutic implications. In this issue, Robciuc et al. (2016) demonstrate that VEGF-B, by displacing VEGF-A from VEGFR1 and activating VEGFR2, increases adipose tissue vascularity, improves insulin sensitivity, diminishes obesity, and alleviates metabolic syndrome.
authors.affiliation: Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: srafii@med.cornell.edu.
authors.forename: Shahin
authors.initials: S
authors.lastname: Rafii
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre (VRC), 3000 Leuven, Belgium. Electronic address: peter.carmeliet@vib-kuleuven.be.
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D006801:Humans; D007333:Insulin Resistance; D009765:Obesity; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D042561:Vascular Endothelial Growth Factor B; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D042561:Vascular Endothelial Growth Factor B; D040301:Vascular Endothelial Growth Factor Receptor-2