title: Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample.
abstract: A total cerebrovascular disease (CeVD) burden scale was previously constructed and an inverse association of CeVD burden and cognition was found. However, the generalizability of the CeVD scale has not been examined.
  
  
  
  The objective was to validate the previously constructed total CeVD burden scale by establishing its association with cognitive function and dementia diagnosis in a community sample.
  
  
  
  Eligible participants were assessed on an extensive neuropsychological battery and underwent MRI scans. The total CeVD scale, comprising markers of both small- and large-vessel diseases, was derived according to previously described criteria. Association of total CeVD burden with global and domain-based cognitive performance and dementia diagnostic utility of the scale was established.
  
  
  
  A total of 863 participants were included in the analysis. A stepwise association of CeVD burden score with global and domain-specific cognitive function was found. Per score increase on the total CeVD burden scale was associated with 3.6 (95% CI = 2.1-6.4) times higher odds of dementia compared to dementia-free.
  
  
  
  The total CeVD burden scale is associated with cognition and dementia in a community sample. Longitudinal studies are required to establish the predictive ability of this scale.
authors.affiliation: Department of Pharmacology, National University of Singapore, Singapore.|Memory Aging and Cognition Centre, National University Health System, Singapore.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, National University of Singapore, Singapore.|Memory Aging and Cognition Centre, National University Health System, Singapore.
authors.forename: Saima
authors.initials: S
authors.lastname: Hilal
authors.affiliation: Department of Psychology, National University of Singapore, Singapore.
authors.forename: Simon L
authors.initials: SL
authors.lastname: Collinson
authors.affiliation: Department of Pharmacology, National University of Singapore, Singapore.|Memory Aging and Cognition Centre, National University Health System, Singapore.
authors.forename: Qun Lin
authors.initials: QL
authors.lastname: Chan
authors.affiliation: Department of Pharmacology, National University of Singapore, Singapore.|Memory Aging and Cognition Centre, National University Health System, Singapore.
authors.forename: Eddie Jun
authors.initials: EJ
authors.lastname: Yi Chong
authors.affiliation: Memory Aging and Cognition Centre, National University Health System, Singapore.|Academic Medicine Research Institute, Duke-NUS Graduate Medical School National University of Singapore, Singapore.
authors.forename: Mohammad Kamran
authors.initials: MK
authors.lastname: Ikram
authors.affiliation: Memory Aging and Cognition Centre, National University Health System, Singapore.|Raffles Neuroscience Centre, Raffles Hospital, Singapore.
authors.forename: Narayanaswamy
authors.initials: N
authors.lastname: Venketasubramanian
authors.affiliation: Academic Medicine Research Institute, Duke-NUS Graduate Medical School National University of Singapore, Singapore.|Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Academic Medicine Research Institute, Duke-NUS Graduate Medical School National University of Singapore, Singapore.|Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
authors.affiliation: Department of Pharmacology, National University of Singapore, Singapore.|Memory Aging and Cognition Centre, National University Health System, Singapore.
authors.forename: Christopher Li-Hsian
authors.initials: CL
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D017281:Cost of Illness; D003704:Dementia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D006801:Humans; D057187:Independent Living / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D012494:Sampling Studies; D012846:Singapore / Q000453:epidemiology
keywords: Cerebrovascular disease; cognition; dementia; diagnosis; vascular burden