title: Endolymphatic space size in patients with Meniere's disease and healthy controls.
abstract: CONCLUSIONS
  The incident ratios of cochlear and/or vestibular endolymphatic hydrops (EH) were significantly higher in the affected ears of patients with Meniere's disease (MD) than in the ears of healthy controls. There were no significant differences between controls and the contralateral ears of MDs.
  
  
  OBJECTIVE
  The aim was to compare the incidence ratios of EH between unilateral/bilateral MD and controls using 3T magnetic resonance imaging (MRI) with intravenous gadolinium.
  
  
  METHODS
  A total of 41 patients were diagnosed with MD: 32 with unilateral MD (uMD) and nine with bilateral MD (bMD). Fifteen healthy volunteers were enrolled as controls. The patients underwent 3T MRI 4 h after intravenous injection of gadolinium.
  
  
  RESULTS
  Cochlear EH was present in 3.3% of 30 ears of 15 controls, 6.3% of 32 contralateral (contra) ears of 32 uMDs, 62.5% of 32 affected ears of 32 uMDs, and 55.6% of 18 affected ears of nine bMDs. Vestibular EH was observed in 6.7% of control ears, 3.1% of contra-uMD ears, 65.6% of affected uMD ears, and in 55.6% of affected bMD ears. Either cochlear or vestibular EH was present in 10.0% of control ears, 6.3% of contra-uMD ears, 81.3% of affected uMD ears, and 44.4% of affected bMD ears.
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Nara Medical University , Sakurai , Nara , Japan ;
authors.forename: Taeko
authors.initials: T
authors.lastname: Ito
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Nara Medical University , Sakurai , Nara , Japan ;
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kitahara
authors.affiliation: b Inui ENT Clinic , Kashihara , Nara , Japan ;
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inui
authors.affiliation: c Department of Radiology , Nara Medical University , Kashihara , Nara , Japan.
authors.forename: Toshiteru
authors.initials: T
authors.lastname: Miyasaka
authors.affiliation: c Department of Radiology , Nara Medical University , Kashihara , Nara , Japan.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kichikawa
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Nara Medical University , Sakurai , Nara , Japan ;
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ota
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Nara Medical University , Sakurai , Nara , Japan ;
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nario
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Nara Medical University , Sakurai , Nara , Japan ;
authors.forename: Yachiyo
authors.initials: Y
authors.lastname: Matsumura
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Nara Medical University , Sakurai , Nara , Japan ;
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yamanaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003051:Cochlea / Q000000981:diagnostic imaging; D005260:Female; D005682:Gadolinium; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008575:Meniere Disease / Q000000981:diagnostic imaging*; D008875:Middle Aged; D014722:Vestibule, Labyrinth / Q000000981:diagnostic imaging; D055815:Young Adult
chemical_list: D005682:Gadolinium
keywords: Endolymphatic hydrops; MRI; asymptomatic ear; gadolinium; healthy controls