title: Simultaneous determination of cosmetics ingredients in nail products by fast gas chromatography with tandem mass spectrometry.
abstract: A rapid and sensitive gas chromatography with tandem mass spectrometry (GC-MS/MS) method has been developed and validated to quantitatively determine cosmetic ingredients, such as toluene, N-methylpyrrolidone, 2,4-dihydroxybenzophenone (benzophenone-1, BP-1), and diethylene glycol dimethacrylate, in nail products. In this procedure, test portions were extracted with acetone, followed by vortexing, sonication, centrifugation, and filtration. During the extraction procedure, BP-1 was derivatized making it amenable to GC-MS analysis, using N,O-​bis(trimethylsilyl)​trifluoroacetamide. The four ingredients were quantified by GC-MS/MS in an electron ionization mode. Four corresponding stable isotopically labeled analogues were selected as internal standards, which were added at the beginning of the sample preparation to correct for recoveries and matrix effects. The validated method was used to screen 34 commercial nail products for these four cosmetic ingredients. The most common ingredients detected in the nail products were toluene and BP-1. Toluene was detected in 26 products and ranged from 1.36 to 173,000μg/g. BP-1 ranged from 18.3 to 2,370μg/g in 10 products.
authors.affiliation: U.S. Food and Drug Administration, Office of Regulatory Science, CFSAN/HFS-717, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA. Electronic address: Wanlong.zhou@fda.hhs.gov.
authors.forename: Wanlong
authors.initials: W
authors.lastname: Zhou
authors.affiliation: U.S. Food and Drug Administration, Office of Regulatory Science, CFSAN/HFS-717, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
authors.forename: Perry G
authors.initials: PG
authors.lastname: Wang
authors.affiliation: U.S. Food and Drug Administration, Office of Regulatory Science, CFSAN/HFS-717, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: Wittenberg
authors.affiliation: U.S. Food and Drug Administration, Office of Regulatory Science, CFSAN/HFS-717, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Rua
authors.affiliation: U.S. Food and Drug Administration, Office of Regulatory Science, CFSAN/HFS-717, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Krynitsky
mesh_terms: D000081:Acetamides / Q000737:chemistry; D000179:Acrylates / Q000032:analysis; D001577:Benzophenones / Q000032:analysis; D003358:Cosmetics / Q000032:analysis*; D005026:Ethylene Glycols / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008689:Methacrylates; D009262:Nails; D011760:Pyrrolidinones / Q000032:analysis; D053719:Tandem Mass Spectrometry / Q000379:methods; D014050:Toluene / Q000032:analysis; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D000081:Acetamides; D000179:Acrylates; D001577:Benzophenones; D003358:Cosmetics; D005026:Ethylene Glycols; D008689:Methacrylates; C103255:N,O-bis(trimethylsilyl)trifluoroacetamide; D011760:Pyrrolidinones; D014297:Trimethylsilyl Compounds; C047521:diethylene glycol dimethacrylate monomer; D014050:Toluene; C038678:N-methylpyrrolidone; C121479:2,4-dihydroxybenzophenone
keywords: 2,4-Dihydroxybenzophenone; Cosmetics; Diethylene glycol dimethacrylate; GC–MS/MS; N-methylpyrrolidone; Nail products; Toluene