title: Standardized Postnatal Management of Infants with Congenital Diaphragmatic Hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update.
abstract: In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension. This article represents the current opinion of all consortium members in Europe for the optimal neonatal treatment of CDH.
authors.affiliation: Erasmus MC - Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Kitty G
authors.initials: KG
authors.lastname: Snoek
authors.forename: Irwin K M
authors.initials: IK
authors.lastname: Reiss
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
authors.forename: Irma
authors.initials: I
authors.lastname: Capolupo
authors.forename: Berndt
authors.initials: B
authors.lastname: Urlesberger
authors.forename: Lucas
authors.initials: L
authors.lastname: Wessel
authors.forename: Laurent
authors.initials: L
authors.lastname: Storme
authors.forename: Jan
authors.initials: J
authors.lastname: Deprest
authors.forename: Thomas
authors.initials: T
authors.lastname: Schaible
authors.forename: Arno
authors.initials: A
authors.lastname: van Heijst
authors.forename: Dick
authors.initials: D
authors.lastname: Tibboel
mesh_terms: D002985:Clinical Protocols / Q000592:standards*; D005060:Europe; D005104:Expert Testimony; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications / Q000628:therapy*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D008991:Monitoring, Physiologic; D011181:Postnatal Care / Q000592:standards*; D017410:Practice Guidelines as Topic; D012121:Respiration, Artificial; D000068677:Sildenafil Citrate / Q000627:therapeutic use
chemical_list: D000068677:Sildenafil Citrate