title: Predicting RNA secondary structures from sequence and probing data.
abstract: RNA secondary structures have proven essential for understanding the regulatory functions performed by RNA such as microRNAs, bacterial small RNAs, or riboswitches. This success is in part due to the availability of efficient computational methods for predicting RNA secondary structures. Recent advances focus on dealing with the inherent uncertainty of prediction by considering the ensemble of possible structures rather than the single most stable one. Moreover, the advent of high-throughput structural probing has spurred the development of computational methods that incorporate such experimental data as auxiliary information.
authors.affiliation: University of Vienna, Faculty of Chemistry, Department of Theoretical Chemistry, Währingerstrasse 17, 1090 Vienna, Austria. Electronic address: ronny@tbi.univie.ac.at.
authors.forename: Ronny
authors.initials: R
authors.lastname: Lorenz
authors.affiliation: University of Vienna, Faculty of Chemistry, Department of Theoretical Chemistry, Währingerstrasse 17, 1090 Vienna, Austria; Medical University of Vienna, Center for Anatomy and Cell Biology, Währingerstraße 13, 1090 Vienna, Austria. Electronic address: michael.wolfinger@univie.ac.at.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Wolfinger
authors.affiliation: University of Vienna, Faculty of Chemistry, Department of Theoretical Chemistry, Währingerstrasse 17, 1090 Vienna, Austria. Electronic address: at@tbi.univie.ac.at.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tanzer
authors.affiliation: University of Vienna, Faculty of Chemistry, Department of Theoretical Chemistry, Währingerstrasse 17, 1090 Vienna, Austria; University of Vienna, Faculty of Computer Science, Research Group Bioinformatics and Computational Biology, Währingerstr. 29, 1090 Vienna, Austria. Electronic address: ivo@tbi.univie.ac.at.
authors.forename: Ivo L
authors.initials: IL
authors.lastname: Hofacker
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D019295:Computational Biology; D003198:Computer Simulation; D006801:Humans; D008958:Models, Molecular; D012313:RNA / Q000737:chemistry*; D059370:RNA Folding; D017423:Sequence Analysis, RNA
chemical_list: D012313:RNA
keywords: RNA secondary structure prediction; Structure probing