title: Dynamic imaging for CAR-T-cell therapy.
abstract: Chimaeric antigen receptor (CAR) therapy is entering the mainstream for the treatment of CD19(+)cancers. As is does we learn more about resistance to therapy and the role, risks and management of toxicity. In solid tumour CAR therapy research the route to the clinic is less smooth with a wealth of challenges facing translating this, potentially hugely valuable, therapeutic option for patients. As we strive to understand our successes, and navigate the challenges, having a clear understanding of how adoptively transferred CAR-T-cells behavein vivoand in human trials is invaluable. Harnessing reporter gene imaging to enable detection and tracking of small numbers of CAR-T-cells after adoptive transfer is one way by which we can accomplish this. The compatibility of certain reporter gene systems with tracers available routinely in the clinic makes this approach highly useful for future appraisal of CAR-T-cell success in humans.
authors.affiliation: ImmunoEngineering Group, Division of Cancer Studies, King's College London, London SE1 9RT, U.K.
authors.forename: Nia
authors.initials: N
authors.lastname: Emami-Shahri
authors.affiliation: ImmunoEngineering Group, Division of Cancer Studies, King's College London, London SE1 9RT, U.K. Department of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, U.K. sophie.papa@kcl.ac.uk.
authors.forename: Sophie
authors.initials: S
authors.lastname: Papa
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D003952:Diagnostic Imaging; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D011948:Receptors, Antigen, T-Cell
keywords: CAR-T-cells; PET-CT; SPECT-CT; dynamic imaging; reporter genes