title: Current trends in oxysterol research.
abstract: In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the immune system, particularly with respect to bacterial and viral infection and to Th17-cell development, and the role of oxysterols in breast cancer. We also discuss the value of oxysterol analysis in the diagnosis of disease.
authors.affiliation: College of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA2 8PP, U.K. w.j.griffiths@swansea.ac.uk y.wang@swansea.ac.uk.
authors.forename: William J
authors.initials: WJ
authors.lastname: Griffiths
authors.affiliation: College of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA2 8PP, U.K.
authors.forename: Jonas
authors.initials: J
authors.lastname: Abdel-Khalik
authors.affiliation: College of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA2 8PP, U.K.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hearn
authors.affiliation: College of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA2 8PP, U.K.
authors.forename: Eylan
authors.initials: E
authors.lastname: Yutuc
authors.affiliation: College of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA2 8PP, U.K.
authors.forename: Alwena H
authors.initials: AH
authors.lastname: Morgan
authors.affiliation: College of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA2 8PP, U.K. w.j.griffiths@swansea.ac.uk y.wang@swansea.ac.uk.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D002470:Cell Survival; D002777:Cholestanols / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000378:metabolism; D007107:Immune System / Q000378:metabolism; D009474:Neurons / Q000166:cytology; D000072376:Oxysterols / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: C582666:5-hydroxy-6-(2-(1H-imidazol-4-yl)ethylamino)cholestan-3-ol; D002777:Cholestanols; D007093:Imidazoles; D000072376:Oxysterols; D011960:Receptors, Estrogen
keywords: RAR-related orphan receptor gamma t (RORγ); cholestenoic acid; cholesterol; hydroxycholesterol; liver X receptor (LXR); sterol regulatory-element binding protein (SREBP)