title: Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin.
abstract: BACKGROUND
  Intravenous lipid emulsion eliminates the toxicity-related symptoms of several drugs. We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats.
  
  
  METHODS
  Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats received digoxin infusion at a rate of 12 mL/h (0.25 mg/mL). Five minutes after the start of digoxin infusion, animals were treated either with 12.4 mL/kg intravenous lipid emulsion (group L) or saline (group C). The primary outcome variable was time elapsed until asystole development. Cumulative dose of digoxin required to induce asystole was also recorded.
  
  
  RESULTS
  Mean time until asystole development in groups C and L were 21.28 ± 8.61 and 32.00 ± 5.41 minutes, respectively (P< .05). The mean lethal doses of digoxin in the groups C and L were 3.97 ± 1.54 and 6.09 ± 0.96 mg/kg, respectively (P< .05).
  
  
  CONCLUSIONS
  Intravenous lipid emulsion prolonged the time until asystole development and increased cumulative lethal dose in rats intoxicated with digoxin.
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation. Electronic address: syurtlu68@gmail.com.
authors.forename: Bülent Serhan
authors.initials: BS
authors.lastname: Yurtlu
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation.
authors.forename: Şule
authors.initials: Ş
authors.lastname: Özbilgin
authors.affiliation: Katip Celebi University, School of Medicine, Department of Anesthesiology and Reanimation.
authors.forename: Derya Arslan
authors.initials: DA
authors.lastname: Yurtlu
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation.
authors.forename: Nilay
authors.initials: N
authors.lastname: Boztaş
authors.affiliation: Dokuz Eylül University, Institute of Health Science, Department of Laboratory Animals Science.
authors.forename: Gonca
authors.initials: G
authors.lastname: Kamacı
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akaltun
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hancı
authors.affiliation: Dokuz Eylül University, Institute of Health Science, Department of Laboratory Animals Science.
authors.forename: Osman
authors.initials: O
authors.lastname: Yılmaz
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D004077:Digoxin / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D006323:Heart Arrest / Q000209:etiology / Q000517:prevention & control*; D007262:Infusions, Intravenous; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000889:Anti-Arrhythmia Agents; D005217:Fat Emulsions, Intravenous; D004077:Digoxin