title: Organocatalytic Enantioselective Michael-Michael-Henry Reaction Cascade. An Entry to Highly Functionalized Hajos-Parrish-Type Ketones with Five to Six Contiguous Stereogenic Centers and Two Quaternary Carbons.
abstract: An organocatalytic enantioselective reaction of 2-methylcyclopentane-1,3-dione, nitroalkene, and α,β-unsaturated aldehyde with the diphenylprolinol catalyst was developed to give the highly functionalized Hajos-Parrish-type ketones with five to six contiguous stereocenters and two quaternary carbon stereogenic centers with high diastereoselectivity and enantioselectivity. The structures of the adducts were unambiguously confirmed by single-crystal X-ray crystallographic analyses of the appropriate products.
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University , Chia-Yi 621, Taiwan, R.O.C.
authors.forename: Arun
authors.initials: A
authors.lastname: Raja
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University , Chia-Yi 621, Taiwan, R.O.C.
authors.forename: Bor-Cherng
authors.initials: BC
authors.lastname: Hong
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University , Chia-Yi 621, Taiwan, R.O.C.
authors.forename: Ju-Hsiou
authors.initials: JH
authors.lastname: Liao
authors.affiliation: Department of Chemistry, National Taiwan University , Taipei 106, Taiwan, R.O.C.
authors.forename: Gene-Hsiang
authors.initials: GH
authors.lastname: Lee