title: Long-term leukopenia in a lung transplanted patient with cystic fibrosis treated with zoledronic acid: a case report.
abstract: Cystic fibrosis (CF) is a serious autosomal recessive genetic disorder associated with chronic lung disease, malabsorption, malnutrition, pancreatic insufficiency and premature respiratory failure. Recent advances in medical science and technology have increased the lifespan of patients with CF, albeit with long-term consequences of the disease, such as osteoporosis, becoming of increasing significance. The medical treatment of osteoporosis in patients with CF or after organ transplantation is still being explored, and no clear guidelines regarding the best choice of bisphosphonate exist. We report a case of a young woman with CF, lung transplantation and low bone mass developing long-term leukopenia after treatment with zoledronic acid. The leukopenia, with a strong affection of the neutrocytes, lasted for 4 months and the condition only went into remission after granulocyte-colony stimulating factor (G-CSF) treatment. It is important to be aware of symptomatic leukopenia in immunosuppressive patients after treatment with zoledronic acid.
authors.affiliation: Department of Cardiology, Nephrology and Endocrinology, Nordsjaellands Hospital-Hillerød, Dyrehavevej 29, DK-3400, Hilleroed, Denmark. azra.karahasanovic.01@regionh.dk.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. azra.karahasanovic.01@regionh.dk.
authors.forename: A
authors.identifier: 0000-0003-1448-618X
authors.initials: A
authors.lastname: Karahasanovic
authors.affiliation: Department of Cardiology, Nephrology and Endocrinology, Nordsjaellands Hospital-Hillerød, Dyrehavevej 29, DK-3400, Hilleroed, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: A-L
authors.initials: AL
authors.lastname: Thorsteinsson
authors.affiliation: Department Respiratory Medicine, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.|Department Lung Transplantation, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: N H
authors.initials: NH
authors.lastname: Bjarnason
authors.affiliation: Department of Cardiology, Nephrology and Endocrinology, Nordsjaellands Hospital-Hillerød, Dyrehavevej 29, DK-3400, Hilleroed, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Eiken
mesh_terms: D000328:Adult; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000188:drug therapy*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007970:Leukopenia / Q000139:chemically induced*; D016040:Lung Transplantation; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
keywords: Bisphosphonates; Cystic fibrosis; Leukopenia; Lung transplant; Osteoporosis; Zoledronic acid