title: KIR genotypic diversity in Portuguese and analysis of KIR gene allocation after allogeneic hematopoietic stem cell transplantation.
abstract: The diversity of killer-cell immunoglobulin-like receptors (KIR) genes was evaluated in Portuguese and the observed genotypic profiles were found related to the ones reported in European populations. The KIR repertoire after hematopoietic stem cell transplantation is determined by these gene frequencies and the KIR group B motifs are the less common. We estimated donor-KIR/recipient-ligand interactions in transplants with related donors and unrelated donors found in a local registry or from abroad. A large fraction of transplants had all three ligands of inhibitory receptors, and therefore, in theory were not prone to natural killer cell (NK) mediated alloreactivity. Furthermore, the distribution of KIR alloreactive interactions was found independent of the donor-recipient genetic proximity, probably because of different gene segregation and comparable KIR frequencies in the donor pools.
authors.affiliation: Lisbon Center for Blood and Transplantation, Instituto Português de Sangue e Transplantação, Lisbon, Portugal.
authors.forename: D
authors.initials: D
authors.lastname: Ligeiro
authors.affiliation: Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics and Evolution-Anthropology Unit, University of Geneva, Geneva, Switzerland.|Transplantation Immunology Unit & National Reference Laboratory for Histocompatibility, Department of Genetic and Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland.
authors.forename: S
authors.identifier: http://orcid.org/0000-0001-6675-5287
authors.initials: S
authors.lastname: Buhler
authors.affiliation: Hematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, EPE, Lisbon, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Abecasis
authors.affiliation: Lisbon Center for Blood and Transplantation, Instituto Português de Sangue e Transplantação, Lisbon, Portugal.
authors.forename: O
authors.initials: O
authors.lastname: Abade
authors.affiliation: Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics and Evolution-Anthropology Unit, University of Geneva, Geneva, Switzerland.|Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Sanchez-Mazas
authors.affiliation: Hematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, EPE, Lisbon, Portugal.|CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal.
authors.forename: M Gomes
authors.initials: MG
authors.lastname: da Silva
authors.affiliation: Lisbon Center for Blood and Transplantation, Instituto Português de Sangue e Transplantação, Lisbon, Portugal.
authors.forename: H
authors.initials: H
authors.lastname: Trindade
mesh_terms: D002503:Centromere / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D006680:HLA Antigens / Q000276:immunology; D006239:Haplotypes / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008024:Ligands; D009018:Morocco; D011174:Portugal; D011544:Pseudogenes / Q000235:genetics; D054340:Receptors, KIR / Q000235:genetics*; D013030:Spain; D016615:Telomere / Q000235:genetics; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens; D008024:Ligands; D054340:Receptors, KIR
keywords: hematopoietic stem cell transplantation; killer immunoglobulin-like receptors genotypic diversity; killer immunoglobulin-like receptors-human leukocyte antigen ligand interaction; natural killer cell alloreactivity