title: Asthma and bronchiectasis exacerbation.
abstract: Bronchiectasis and asthma are common respiratory diseases worldwide. However, the influence of asthma on bronchiectasis remains unclear. The objective of this study is to analyse the effects of asthma on bronchiectasis exacerbation.Data from inpatients diagnosed with bronchiectasis with or without asthma at Shanghai Pulmonary Hospital (Shanghai, China) between January 2013 and December 2014 were retrospectively collected and analysed. 249 patients with only bronchiectasis and 214 patients with both bronchiectasis and asthma were included in the study. Follow-up records were used to evaluate the effect of asthma on bronchiectasis exacerbation.The variables found to be independently associated with bronchiectasis exacerbations were age (OR 1.07, 95% CI 1.03-1.11; p<0.001), duration of symptoms (OR 1.06, 95% CI 1.03-1.09; p<0.001), the presence of asthma (OR 2.6, 95% CI 1.15-5.88; p=0.021), forced expiratory volume in 1 s <50% predicted (OR 4.03, 95% CI 1.75-9.26; p=0.001), isolation of Pseudomonas aeruginosa in sputum (OR 2.41, 95% CI 1.00-5.79; p=0.05) and lung lesion extension to more than two lobes (OR 2.73, 95% CI 1.16-6.45; p=0.022).The existence of asthma was associated with an independent increase in risk of bronchiectasis exacerbation.
authors.affiliation: Dept of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Dept of Medicine, Soochow University, Suzhou, China Both authors contributed equally.
authors.forename: Bei
authors.initials: B
authors.lastname: Mao
authors.affiliation: Dept of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Dept of Medicine, Soochow University, Suzhou, China Both authors contributed equally.
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Yang
authors.affiliation: Dept of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Hai-Wen
authors.initials: HW
authors.lastname: Lu
authors.affiliation: Dept of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Dept of Medicine, Soochow University, Suzhou, China jfxucn@gmail.com.
authors.forename: Jin-Fu
authors.initials: JF
authors.lastname: Xu
mesh_terms: D000367:Age Factors; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000175:diagnosis; D015992:Body Mass Index; D001987:Bronchiectasis / Q000150:complications* / Q000175:diagnosis; D002681:China; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D007297:Inpatients; D008168:Lung / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011552:Pseudomonas Infections / Q000150:complications; D011550:Pseudomonas aeruginosa; D011788:Quality of Life; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D013183:Sputum; D014057:Tomography, X-Ray Computed