title: Genetic Characterization of Archived Bunyaviruses and their Potential for Emergence in Australia.
abstract: To better understand the diversity of bunyaviruses and their circulation in Australia, we sequenced 5 viruses (Gan Gan, Trubanaman, Kowanyama, Yacaaba, and Taggert) isolated and serologically identified 4 decades ago as members of the family Bunyaviridae. Gan Gan and Trubanaman viruses almost perfectly matched 2 recently isolated, purportedly novel viruses, Salt Ash and Murrumbidgee viruses, respectively. Kowanyama and Yacaaba viruses were identified as being related to members of a large clade containing pathogenic viruses. Taggert virus was confirmed as being a nairovirus; several viruses of this genus are pathogenic to humans. The genetic relationships and historical experimental infections in mice reveal the potential for these viruses to lead to disease emergence.
authors.forename: Bixing
authors.initials: B
authors.lastname: Huang
authors.forename: Cadhla
authors.initials: C
authors.lastname: Firth
authors.forename: Daniel
authors.initials: D
authors.lastname: Watterson
authors.forename: Richard
authors.initials: R
authors.lastname: Allcock
authors.forename: Agathe M G
authors.initials: AM
authors.lastname: Colmant
authors.forename: Jody
authors.initials: J
authors.lastname: Hobson-Peters
authors.forename: Peter
authors.initials: P
authors.lastname: Kirkland
authors.forename: Glen
authors.initials: G
authors.lastname: Hewitson
authors.forename: Jamie
authors.initials: J
authors.lastname: McMahon
authors.forename: Sonja
authors.initials: S
authors.lastname: Hall-Mendelin
authors.forename: Andrew F
authors.initials: AF
authors.lastname: van den Hurk
authors.forename: David
authors.initials: D
authors.lastname: Warrilow
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001315:Australia / Q000453:epidemiology; D002043:Bunyaviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000648:ultrastructure; D002044:Bunyaviridae Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D016679:Genome, Viral; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins
keywords: Australia; arbovirus; bunyavirus; emergence; phylogenetics; sequencing; viruses