title: Recent advances (2010-2015) in studies of cerium oxide nanoparticles' health effects.
abstract: Cerium oxide nanoparticles, widespread applied in our life, have attracted much concern for their human health effects. However, most of the works addressing cerium oxide nanoparticles toxicity have only used in vitro models or in vivo intratracheal instillation methods. The toxicity studies have varied results and not all are conclusive. The information about risk assessments derived from epidemiology studies is severely lacking. The knowledge of occupational safety and health (OSH) for exposed workers is very little. Thus this review focuses on recent advances in studies of toxicokinetics, antioxidant activity and toxicity. Additionally, aim to extend previous health effects assessments of cerium oxide nanoparticles, we summarize the epidemiology studies of engineered cerium oxide nanoparticles used as automotive diesel fuel additive, aerosol particulate matter in air pollution, other industrial ultrafine and nanoparticles (e.g., fumes particles generated in welding and flame cutting processes).
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira Taipa, Macau 999078, China; Shanghai Institute of Occupational Safety and Health (SIOSH), 369 North Chengdu Road, Shanghai 200041, China. Electronic address: jian_2001@sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira Taipa, Macau 999078, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira Taipa, Macau 999078, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira Taipa, Macau 999078, China. Electronic address: bian_ying_um@sina.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Bian
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D002563:Cerium / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D053768:Metal Nanoparticles / Q000633:toxicity
chemical_list: D000975:Antioxidants; D002563:Cerium; C030583:ceric oxide
keywords: Antioxidant activity; Cerium oxide nanoparticles; Epidemiology studies; Health effects; Toxicity