title: Swinger RNA self-hybridization and mitochondrial non-canonical swinger transcription, transcription systematically exchanging nucleotides.
abstract: Stem-loop hairpins punctuate mitochondrial post-transcriptional processing. Regulation of mitochondrial swinger transcription, transcription producing RNAs matching the mitogenome only assuming systematic exchanges between nucleotides (23 bijective transformations along 9 symmetric exchanges X<>Y, e.g. A<>G, and 14 asymmetric exchanges X>Y>Z>X, e.g. A>G>C>A) remains unknown. Does swinger RNA self-hybridization regulate swinger, as regular, transcription? Groups of 8 swinger transformations share canonical self-hybridization properties within each group, group 0 includes identity (regular) transcription. The human mitogenome has more stem-loop hairpins than randomized sequences for all groups. Group 2 transformations reveal complementarity of the light strand replication origin (OL) loop and a neighboring tRNA gene, detecting the longtime presumed OL/tRNA homology. Non-canonical G=U pairings in hairpins increases with swinger RNA detection. These results confirm biological relevancy of swinger-transformed DNA/RNA, independently of, and in combination with, previously detected swinger DNA/RNA and swinger peptides. Swinger-transformed mitogenomes include unsuspected multilayered information.
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, Faculté de Médecine, URMITE CNRS-IRD 198 UMER 6236, Université de la Méditerranée, Marseille, France. Electronic address: timonuslepidus@gmail.com.
authors.forename: Hervé
authors.initials: H
authors.lastname: Seligmann
mesh_terms: D020137:Base Pair Mismatch / Q000235:genetics; D001483:Base Sequence; D004261:DNA Replication / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D054629:Genome, Mitochondrial; D006801:Humans; D006824:Hybridization, Genetic; D055029:Inverted Repeat Sequences; D008928:Mitochondria / Q000235:genetics*; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000235:genetics*; D012313:RNA / Q000737:chemistry / Q000235:genetics*; D012344:RNA, Transfer, Ala / Q000235:genetics; D018709:Statistics, Nonparametric; D014158:Transcription, Genetic
chemical_list: D004272:DNA, Mitochondrial; D009711:Nucleotides; D012344:RNA, Transfer, Ala; D012313:RNA
keywords: Mimivirus; Palindrome; Systematic deletions; Virophage; delRNA