title: Serralongamines B-D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages.
abstract: Three new Lycopodium alkaloids, serralongamines B-D (1-3), have been isolated from the club moss Lycopodium serratum var. longipetiolatum, and the structures were elucidated on the basis of spectroscopic data and chemical transformation. 1 and 3 significantly exhibited the inhibitory activity against foam cell formation in human macrophages, one of characteristic features of early atherosclerotic lesions.
authors.affiliation: School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi 274-8555, Chiba, Japan; Graduate School of Pharmaceutical Sciences, Nagoya-City University, 3-1, Tanabe-Dori, Mizuho-ku, Nagoya 467-8603, Aichi, Japan.
authors.forename: Kan'ichiro
authors.initials: K
authors.lastname: Ishiuchi
authors.affiliation: School of Pharmacy, China Medical University, No. 91, Hsueh-Shih R., Taichung 40402, Taiwan.
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Jiang
authors.affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Kumamoto, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fujiwara
authors.affiliation: School of Pharmacy, China Medical University, No. 91, Hsueh-Shih R., Taichung 40402, Taiwan. Electronic address: jbwu@mail.cmu.edu.tw.
authors.forename: Jin-Bin
authors.initials: JB
authors.lastname: Wu
authors.affiliation: School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi 274-8555, Chiba, Japan. Electronic address: kitanaka.susumu@nihon-u.ac.jp.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
mesh_terms: D004305:Dose-Response Relationship, Drug; D005487:Foam Cells / Q000187:drug effects*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D032502:Lycopodium / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects*; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D011804:Quinolines; C000620494:serralongamine B; C000620495:serralongamine D
keywords: Atherosclerosis; Foam cells; Human monocyte-derived macrophages; Lycopodium alkaloids; Lycopodium serratum var. longipetiolatum; Serralongamines B, C and D