title: Leucine-derived cyanoglucosides from the aerial parts of Sorbaria sorbifolia (L.) A. Braun.
abstract: Six new cyanoglucosides, 2S-cardiospermin-5-benzoate (1), 2R-cardiospermin-5-p-hydroxybenzoate (2), 2S-cardiospermin-5-cis-p-coumarate (3), isocardiospermin-5-p-hydroxybenzoate (4), sutherlandin-5-p-hydroxybenzoate (5), and sutherlandin-5-cis-p-coumarate (6), together with 17 known compounds were isolated from Sorbaria sorbifolia. The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS and ECD experiments. The biosynthetic relationship of 1-9 was also discussed. The cyanoglucosides (1-9) and 15 exhibited moderate inhibitory effect on nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).
authors.affiliation: School of Gerontology, Binzhou Medical University, Yantai 264003, PR China; Marine and Natural Drugs Research Center, Shandong, International Biotechnology Park Development Co., Ltd, Yantai 264670, PR China.
authors.forename: Gui-Wu
authors.initials: GW
authors.lastname: Qu
authors.affiliation: Marine and Natural Drugs Research Center, Shandong, International Biotechnology Park Development Co., Ltd, Yantai 264670, PR China.
authors.forename: Chang-Jing
authors.initials: CJ
authors.lastname: Wu
authors.affiliation: Marine and Natural Drugs Research Center, Shandong, International Biotechnology Park Development Co., Ltd, Yantai 264670, PR China.
authors.forename: Shi-Zhou
authors.initials: SZ
authors.lastname: Gong
authors.affiliation: Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai 264003, PR China.
authors.forename: Ze-Ping
authors.initials: ZP
authors.lastname: Xie
authors.affiliation: School of Gerontology, Binzhou Medical University, Yantai 264003, PR China. Electronic address: lucky_lcj@sina.com.
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Lv
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D062385:Hydroxybenzoates / Q000737:chemistry* / Q000302:isolation & purification; D007930:Leucine / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D000067996:RAW 264.7 Cells; D027824:Rosaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D003373:Coumaric Acids; D006027:Glycosides; D062385:Hydroxybenzoates; C421546:sutherlandin-5-p-coumarate; D009569:Nitric Oxide; D007930:Leucine
keywords: Anti-inflammation activity; Cardiospermin; Cyanoglucosides; Sorbaria sorbifolia; Sutherlandin