title: Allele and haplotype diversity of new multiplex of 19 ChrX-STR loci in Han population from Guanzhong region (China).
abstract: X-chromosomal short tandem repeats (X-STRs) have been proved to be useful for some deficiency paternity cases in recent years. Here, we studied the genetic polymorphisms of 19 X-STR loci (DXS10148-DXS10135-DXS8378, DXS10159-DXS10162-DXS10164, DXS7132-DXS10079-DXS10074-DXS10075, DXS6809-DXS6789, DXS7424-DXS101, DXS10103-HPRTB-DXS10101 and DXS7423-DXS10134) in 252 male and 222 female individuals from Guanzhong Han population, China. No deviation for all 19 loci was observed from the Hardy-Weinberg equilibrium. The polymorphism information content values of the panel of 19 loci were more than 0.5 with the exception of the locus DXS7423. The combined power of discrimination were 0.9999999999999999999994340 in females and 0.9999999999997662 in males, respectively; and the combined mean exclusion chances were 0.999999993764 in duos and 0.999999999997444 in trios, respectively. The haplotype diversities for all the seven clusters of linked loci were more than 0.9. The results showed that the panel of 19 X-STR loci were powerful for forensic applications in Guanzhong Han population. Locus by locus population comparisons showed significant differences at more than seven loci between Guanzhong Han population and the groups from North America, Europe and Africa.
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, P. R. China.|Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China.
authors.forename: Yu-Dang
authors.initials: YD
authors.lastname: Zhang
authors.affiliation: Blood Center of Shaanxi Province, Xi'an, P. R. China.|College of Life Sciences, Shaanxi Normal University, Xi'an, P. R. China.
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Shen
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, P. R. China.|Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China.
authors.forename: Hao-Tian
authors.initials: HT
authors.lastname: Meng
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, P. R. China.|Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Guo
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, P. R. China.|Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Key Laboratory of Genome Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P. R. China.
authors.forename: Jiang-Wei
authors.initials: JW
authors.lastname: Yan
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, P. R. China.|Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi, P. R. China.
authors.forename: Yao-Shun
authors.initials: YS
authors.lastname: Liu
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, P. R. China.|Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi, P. R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Mei
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.
authors.forename: Rui-Zhe
authors.initials: RZ
authors.lastname: Huang
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, P. R. China.
authors.forename: Bo-Feng
authors.initials: BF
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D002681:China; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D053803:Forensic Genetics / Q000379:methods; D056426:Genetic Loci / Q000235:genetics; D005828:Genetics, Population / Q000379:methods; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic
keywords: AGCU X19; Guanzhong Han population; Haplotype diversity; X-chromosomal STRs