title: Vaccination of dogs with Trypanosoma rangeli induces antibodies against Trypanosoma cruzi in a rural area of Córdoba, Argentina.
abstract: Dogs play a major role in the domestic cycle of Trypanosoma cruzi, acting as reservoirs. In a previous work we have developed a model of vaccination of dogs in captivity with nonpathogenic Trypanosoma rangeli epimastigotes, resulting in the production of protective antibodies against T. cruzi, with dramatic decrease of parasitaemia upon challenge with 100,000 virulent forms of this parasite. The aim of this work was to evaluate the immunogenicity of this vaccine in dogs living in a rural area. Domestic dogs, free from T. cruzi infection, received three immunisations with fixed T. rangeli epimastigotes. Dogs were not challenged with T. cruzi, but they were left in their environment. This immunisation induced antibodies against T. cruzi for more than three years in dogs in their natural habitat, while control dogs remained serologically negative.
authors.affiliation: School of Medicine, National University of Córdoba, Córdoba, Argentina.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Basso
authors.affiliation: Catholic University of Córdoba, Córdoba, Argentina.
authors.forename: Vanina
authors.initials: V
authors.lastname: Marini
authors.affiliation: Ministry of Health, Córdoba, Argentina.
authors.forename: Diego
authors.initials: D
authors.lastname: Gauna
authors.affiliation: School of Medicine, National University of Córdoba, Córdoba, Argentina.
authors.forename: Maria
authors.initials: M
authors.lastname: Frias
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D001118:Argentina; D014355:Chagas Disease / Q000517:prevention & control / Q000662:veterinary*; D004285:Dogs; D018512:Parasitemia / Q000276:immunology / Q000662:veterinary; D016052:Protozoan Vaccines / Q000008:administration & dosage / Q000276:immunology*; D012424:Rural Population; D014349:Trypanosoma cruzi / Q000276:immunology*; D057509:Trypanosoma rangeli / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D016052:Protozoan Vaccines