title: Rh-Catalyzed Stereospecific Synthesis of Allenes from Propargylic Benzoates and Arylboronic Acids.
abstract: An enantiospecific approach to the synthesis of optically active, trisubstituted allenes from chiral propargylic benzoates and arylboronic acids has been developed. The transformation is catalyzed by a Rh-(P,olefin) complex formed in situ from [{Rh(cod)Cl}2] and a readily available phosphoramidite ligand. The method furnishes an assortment of diverse allenes in high yields and excellent enantiospecificity under mild conditions.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , HCI H335, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ruchti
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , HCI H335, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira