title: Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright Future.
abstract: BACKGROUND
  The high sequence and structural homology among the hsp90 paralogs - Hsp90α, Hsp90β, Grp94, and Trap-1 - has made the development of paralog-specific inhibitors a challenging proposition.
  
  
  OBJECTIVE
  This review surveys the state of developments in structural analysis, compound screening, and structure-based design that have been brought to bear on this problem.
  
  
  RESULTS
  First generation compounds that selectively bind to Hsp90, Grp94, or Trap-1 have been identified.
  
  
  CONCLUSIONS
  With the proof of principle firmly established, the prospects for further progress are bright.
authors.affiliation: Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY, 14203, USA. gewirth@hwi.buffalo.edu.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Gewirth
mesh_terms: D000595:Amino Acid Sequence; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006801:Humans; D012118:Resorcinols / Q000737:chemistry; D017386:Sequence Homology, Amino Acid
chemical_list: D018841:HSP90 Heat-Shock Proteins; D012118:Resorcinols; C031389:resorcinol