title: Spatial Orientation and Morphology of the Pulmonary Artery: Relevance to Optimising Design and Positioning of a Continuous Pressure Monitoring Device.
abstract: Personalised treatment of heart disease requires an understanding of the patient-specific characteristics, which can vary over time. A newly developed implantable surface acoustic wave pressure sensor, capable of continuous monitoring of the left ventricle filling pressure, is a novel device for personalised management of patients with heart disease. However, a one-size-fits-all approach to device sizing will affect its positioning within the pulmonary artery and its relationship to the interrogating device on the chest wall on a patient-specific level. In this paper, we analyse the spatial orientation and morphology of the pulmonary artery and its main branches in patients who could benefit from the device and normal controls. The results could optimise the design of the sensor, its stent, and importantly its placement, ensuring long-term monitoring in patient groups.
authors.affiliation: The Hamlyn Centre, Imperial College London, Room 414A, Bessemer Building, South Kensington Campus, London, SW7 2AZ, UK. su-lin.lee@imperial.ac.uk.
authors.forename: Su-Lin
authors.initials: SL
authors.lastname: Lee
authors.affiliation: Aswan Heart Centre, Magdi Yacoub Foundation, Aswan, Egypt.
authors.forename: Heba
authors.initials: H
authors.lastname: Aguib
authors.affiliation: Qatar Cardiovascular Research Center, Doha, Qatar.
authors.forename: Julien
authors.initials: J
authors.lastname: Chapron
authors.affiliation: Institute of Biomedical Engineering, Imperial College London, London, UK.
authors.forename: Reza
authors.initials: R
authors.lastname: Bahmanyar
authors.affiliation: Institute of Child Health, University College, London, UK.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Borghi
authors.affiliation: Analog Devices, Cork, Ireland.
authors.forename: Olive
authors.initials: O
authors.lastname: Murphy
authors.affiliation: Institute of Biomedical Engineering, Imperial College London, London, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: McLeod
authors.affiliation: Aswan Heart Centre, Magdi Yacoub Foundation, Aswan, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: ElGuindy
authors.affiliation: Aswan Heart Centre, Magdi Yacoub Foundation, Aswan, Egypt.|Harefield Heart Science Centre, National Heart & Lung Institute, Imperial College London, London, UK.
authors.forename: Magdi
authors.initials: M
authors.lastname: Yacoub
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D000328:Adult; D000368:Aged; D062186:Arterial Pressure; D018660:Blood Pressure Monitoring, Ambulatory / Q000295:instrumentation*; D015924:Blood Pressure Monitors; D016022:Case-Control Studies; D000072226:Computed Tomography Angiography; D004867:Equipment Design; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013997:Time Factors; D014160:Transducers, Pressure; D016277:Ventricular Function, Left; D017725:Ventricular Pressure
keywords: Device design; Morphology; Orientation; Pressure monitoring; Pulmonary artery