title: Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy.
abstract: DNA methyltransferase 1 (DNMT1) plays a pivotal role in maintaining DNA methylation status. Polymorphisms of DNMT1 may modify the role of DNMT1 in prognosis of gastric cancer (GC). Our aim was to test whether polymorphisms of DNMT1 gene were associated with overall survival of GC. Four hundred and forty-seven GC patients who underwent radical tumorectomy were enrolled in the study. Five tagging SNPs (rs10420321, rs16999593, rs2228612, rs2228611, and rs2288349) of the DNMT1 gene were genotyped by TaqMan assays. Kaplan-Meier survival plots and Cox proportional hazard regression were used to analyze the associations between SNPs of DNMT1 and survival of GC. Patients carrying rs2228611 GA/AA genotype tended to live longer than those bearing the GG genotype (HR 0.68, 95% CI: 0.51-0.91, P = 0.007). Further multivariate Cox regression analysis showed that rs2228611 was an independent prognostic factor (GA/AA versus GG: OR 0.67, 95% CI 0.49-0.91, P = 0.010). Nevertheless, other SNPs did not show any significant associations with survival of GC. Polymorphisms of the DNMT1 gene may affect overall survival of GC. The SNP rs2228611 has the potentiality to serve as an independent prognostic marker for GC patients.
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wu
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Donghui
authors.initials: D
authors.lastname: Cao
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Lili
authors.initials: L
authors.lastname: You
authors.affiliation: Division of Pathology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Meishan
authors.initials: M
authors.lastname: Jin
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Simin
authors.initials: S
authors.lastname: Wen
authors.affiliation: Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Cao
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; C000619380:DNMT1 protein, human