title: Killing Lymphoma with Smac-Mimetics: As Easy as ABC?
abstract: Smac-mimetics are compounds that target cellular Inhibitor of APoptosis (cIAP) proteins and induce tumor cell death. In this issue of Cancer Cell, Yang and colleagues (2016) identify cIAPs at the CARD11-MALT1-BCL10 complex in the ABC subtype of diffuse large B cell lymphoma (DLBCL), making this malignancy a prime target for these drugs.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia. Electronic address: nachbur@wehi.edu.au.
authors.forename: Ueli
authors.initials: U
authors.lastname: Nachbur
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Silke
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D016403:Lymphoma, Large B-Cell, Diffuse; D016328:NF-kappa B / Q000378:metabolism
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D016328:NF-kappa B