title: Changes in Central Auditory Processing in Patients with Mesial Temporal Lobe Epilepsy after Anterior Temporal Lobectomy with Amygdalohippocampectomy.
abstract: OBJECTIVE
  This study aimed to determine the effects of anterior temporal lobectomy with amygdalohippocampectomy (ATL-AH) on central auditory processing (CAP) in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS), and to identify factors that may contribute to the postoperative worsening of CAP.
  
  
  METHODS
  Frequency-pattern, duration-pattern, and dichotic tests were performed before and after epilepsy surgery in 22 patients with normal hearing according to pure-tone audiometry.
  
  
  RESULTS
  No significant difference in CAP scores was detected between pre- and postoperative tests, but there was a strong association between surgery in the language-dominant temporal lobe and postoperative worsening in the non-dominant-side dichotic test (p<0.05). The probability of a decreased performance in a non-dominant-side dichotic test after surgery was 7.5-fold greater in patients who underwent surgery on the dominant temporal lobe compared with the nondominant temporal lobe. No significant association of postoperative worsening in CAP with the verbal, nonverbal intelligence quotient, or right- or left-side lobectomy was noted.
  
  
  CONCLUSIONS
  These results suggest that ATL-AH on the dominant side in patients with mTLE-HS worsens the CAP ability in the non-dominant-side dichotic test.
authors.affiliation: Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.|Department of Neurology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Su Hyun
authors.initials: SH
authors.lastname: Han
authors.affiliation: Department of Neurology, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Lee
authors.affiliation: Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Choi
authors.affiliation: Department of Neurology, Jeonbuk University Hospital, College of Medicine, Jeonbuk University, Jeonju, Korea.
authors.forename: Han Uk
authors.initials: HU
authors.lastname: Ryu
authors.affiliation: Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. jkkang@amc.seoul.kr.
authors.forename: Joong Koo
authors.initials: JK
authors.lastname: Kang
authors.affiliation: Department of Otolaryngology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Chung
keywords: amygdalohippocampectomy; auditory perceptual disorder; central auditory processing disorder; hippocampus; temporal lobe epilepsy; temporal lobectomy