title: [Feasibility study of dynamic contrast enhanced magnetic resonance imaging qualitative diagnosis of musculoskeletal tumors].
abstract: To investigate the feasibility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters in differentiating musculoskeletal tumors with different behaviours of pathological findings before therapy.
  
  
  
  A total of 34 subjects of musculoskeletal tumors were involved in this retrospective analysis. DCE-MRI was performed using a fat-saturated 3D VIBE (volumetric interpolated breath-hold exam) imaging sequence with following parameters: FA, 10 degree; TR/TE, 5.6/2.4 ms; slice thickness, 4.0 mm with no intersection gap; field of view, 310 mm×213 mm; matrix, 256×178; voxel size, 1.2 mm×1.2 mm×4.0 mm; parallel imaging acceleration factor. The actuation time for the DCE-MRI sequence was 255 s with a temporal resolution of 5 s and 40 image volumes. Using pathological results as a gold standard, tumors were divided into benign, borderline and malignant tumors. Toft's model was used for calculation of K(trans) (volume transfer constant), Ve (extravascular extracellular space distribute volume per unit tissue volume) and Kep (microvascular permeability reflux constant). Those parameters were compared between the lesions and the control tissues using paired t tests. The one-way analysis of variance was used to assess the difference among benign, borderline and malignant tumors. P values <0.05 difference was statistically significant.
  
  
  
  Based on the WHO Classification of Tumours of Soft Tissue and Bone(2012) criteria, 34 patients were divided into three groups: 11 for benign tumors, 12 for borderline tumors, and 11 for malignancies. Compared with control tissues, K(trans) and Kep showed no difference, but Ve was increased in benign tumors, Kep showed no difference, but K(trans) and Ve were increased in borderline tumors,K(trans), Kep and Ve were increased in malignant tumors. K(trans) (P<0.001) and Kep (P<0.01) were significantly higher in malignant tumors than in benign and borderline tumors, but did not show any difference between benign tumors and borderline tumors. Ve was significantly higher in malignant tumors than in benign (P<0.05), but did not show any difference between malignant and borderline tumors, benign tumors and borderline tumors (P>0.05).
  
  
  
  DCE-MRI technique is useful to evaluate the pathological behaviour of musculoskeletal tumors. The quantitative analysis of DCE parameters in conjunction with conventional MR images can improve the accuracy of musculoskeletal tumor qualitative analysis.
authors.affiliation: Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Siemens Healthcare, Magnetic Resonance Collaboration Northeast Asia, Beijing 100102, China.
authors.forename: P L
authors.initials: PL
authors.lastname: Zuo
authors.affiliation: Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
authors.forename: K B
authors.initials: KB
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
authors.forename: A H
authors.initials: AH
authors.lastname: Yu
authors.affiliation: Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
authors.forename: X G
authors.initials: XG
authors.lastname: Cheng
mesh_terms: D003287:Contrast Media; D005240:Feasibility Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009140:Musculoskeletal Diseases / Q000000981:diagnostic imaging*; D009369:Neoplasms / Q000145:classification / Q000000981:diagnostic imaging*; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media