title: UV-Responsive Supramolecular Vesicles with Double Hydrophobic Chains.
abstract: In order to improve the stability of polymeric vesicles, supramolecular vesicles are developed via self-assembly of the inclusion of γ-cyclodextrin (γ-CD) and 1-pyrenemethyl palmitate (Py-pal). The inclusion has one hydrophilic head and double hydrophobic tails, which looks like the phospholipid. From the transmission electron microscopy (TEM) image, it can be observed that the average diameter of supramolecular vesicles is approximately 55 nm and there is a huge cavity in supramolecular vesicles. Due to the photo-breakable ester of Py-pal, supramolecular vesicles are broken under UV irradiation. Supramolecular vesicles are used as UV-responsive drug carriers to release the hydrophilic drug such as doxorubicin hydrochloride (DOX•HCl).
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan, 430074, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Dai
authors.affiliation: School of Chemical Engineering and Technology, Shanxi Key Laboratory of Energy Chemical Process Intensification, Xi'an Jiao Tong University, Xi'an, 710049, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Renxi
authors.initials: R
authors.lastname: Zhuo
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D010168:Palmitates / Q000737:chemistry*; D014466:Ultraviolet Rays; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D008081:Liposomes; D010168:Palmitates; D047408:gamma-Cyclodextrins
keywords: UV-responsiveness; cyclodextrins; host-guest interactions; pyrenes; supramolecular vesicles