title: Physical exercise, pain and musculoskeletal function in patients with haemophilia: a systematic review.
abstract: BACKGROUND
  Exercise can provide numerous benefits to haemophilia patients, including bleeding reduction in muscles and joints.
  
  
  OBJECTIVE
  This systematic review (SR) aims to evaluate the effects of physical exercise on pain and the musculoskeletal function of patients with hemophilia.
  
  
  METHODS
  Literature searches of Pubmed, Web of Science, PEDro, Cochrane, Clinical Trials SciELO and Lilacs were performed. The risks of bias were measured using the JADAD scale.
  
  
  RESULTS
  Nine controlled clinical trials were included in the SR.
  
  
  CONCLUSIONS
  Physical exercise can promote a reduction in the perception of pain and can increase ROM and muscle strength in haemophilia patients. Future RCTs with greater methodological rigor that focus on the parameters used to prescribe exercises are necessary.
authors.affiliation: Resident of the Adult and Elderly Health Programme of the Clinics Hospital - Federal University of Paraná (HC/UFPR), Curitiba, PR, Brazil.
authors.forename: G S
authors.initials: GS
authors.lastname: Schäfer
authors.affiliation: Internal Medicine Masters/Doctorate Programme of the Federal University of Paraná (UFPR), Multi-Professional Residency Programme in Health and Health Professions (HC/UFPR), Curitiba, PR, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Valderramas
authors.affiliation: Master's/Doctorate Programme in Physical Education of the Federal University of Paraná (UFPR), Multi-Professional Residency Programme in Health and Health Professions (HC/UFPR), Curitiba, PR, Brazil.
authors.forename: A R
authors.initials: AR
authors.lastname: Gomes
authors.affiliation: Resident of the Adult and Elderly Health Programme of the Clinics Hospital - Federal University of Paraná (HC/UFPR), Curitiba, PR, Brazil.
authors.forename: M B
authors.initials: MB
authors.lastname: Budib
authors.affiliation: Multi-Professional Residency Programme in Health and Health Professions (HC/UFPR), Curitiba, PR, Brazil.
authors.forename: Á L P
authors.initials: ÁL
authors.lastname: Wolff
authors.affiliation: Multi-Professional Residency Programme in Health and Health Professions (HC/UFPR), Curitiba, PR, Brazil.
authors.forename: A A T
authors.initials: AA
authors.lastname: Ramos
mesh_terms: D002986:Clinical Trials as Topic; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D053580:Muscle Strength / Q000502:physiology*; D010146:Pain / Q000517:prevention & control*; D011788:Quality of Life
keywords: exercise; haemophilia; physiotherapy; range of motion