title: Palladium-Catalyzed Carbamate-Directed Regioselective Halogenation: A Route to Halogenated Anilines.
abstract: This study describes an efficient method for ortho-selective halogenation of N-arylcarbamates under mild conditions for the first time. Although being weakly coordinating, N-arylcarbamates act very well as a removable directing group for activation of C-H bonds. The developed procedure results in extremely valuable halogenated N-arylcarbmates that can further be hydrolyzed to halogenated anilines. The obtained reaction conditions showed broad scope and wide functional group tolerance. All the products were formed in good yields with extremely high selectivity.
authors.affiliation: Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology , Azadi Street, 111559516 Tehran, Iran.
authors.forename: Firouz Matloubi
authors.initials: FM
authors.lastname: Moghaddam
authors.affiliation: Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology , Azadi Street, 111559516 Tehran, Iran.
authors.forename: Ghazal
authors.initials: G
authors.lastname: Tavakoli
authors.affiliation: Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology , Azadi Street, 111559516 Tehran, Iran.
authors.forename: Borna
authors.initials: B
authors.lastname: Saeednia
authors.affiliation: Institut für Chemie, Universität Rostock , Albert-Einstein-Strasse 3a, 18059 Rostock, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
authors.affiliation: Institut für Chemie, Universität Rostock , Albert-Einstein-Strasse 3a, 18059 Rostock, Germany.
authors.forename: Behzad
authors.initials: B
authors.lastname: Jafari