title: Normal tissue considerations and dose-volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer.
abstract: Hypofractionated radiation therapy (RT) regimes in non-small cell lung cancer (NSCLC) have become increasingly popular with a number of international trials currently underway. The majority of the dose-volume-constraints (DVCs) published in the literature refer to conventional 2Gy per fraction deliveries. Here relevant organs-at-risk (OARs) are identified and available dose-volume constraint data discussed and summarised for moderately hypofractionated NSCLC regimes. The OARs examined include lung, brachial plexus, heart, oesophagus, airway and spinal cord. Where available the toxicity rates are also reported with all data summarised tabulated to aid its use in the clinic.
authors.affiliation: Dept. of Physics, St. Luke's Radiation Oncology Network, St. Luke's Hospital, Dublin, Ireland; UCD School of Physics, University College Dublin, Ireland.
authors.forename: Cathy
authors.initials: C
authors.lastname: Fleming
authors.affiliation: Dept. of Radiation Oncology, St. Luke's Radiation Oncology Network, St. Luke's Hospital, Dublin, Ireland.
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Cagney
authors.affiliation: Dept. of Physics, St. Luke's Radiation Oncology Network, St. Luke's Hospital, Dublin, Ireland; UCD School of Physics, University College Dublin, Ireland.
authors.forename: Serena
authors.initials: S
authors.lastname: O'Keeffe
authors.affiliation: Dept. of Radiation Oncology, St. Luke's Radiation Oncology Network, St. Luke's Hospital, Dublin, Ireland.
authors.forename: Sinead M
authors.initials: SM
authors.lastname: Brennan
authors.affiliation: Dept. of Radiation Oncology, St. Luke's Radiation Oncology Network, St. Luke's Hospital, Dublin, Ireland.
authors.forename: John G
authors.initials: JG
authors.lastname: Armstrong
authors.affiliation: Dept. of Physics, St. Luke's Radiation Oncology Network, St. Luke's Hospital, Dublin, Ireland.
authors.forename: Brendan
authors.initials: B
authors.lastname: McClean
mesh_terms: D001917:Brachial Plexus / Q000528:radiation effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004947:Esophagus / Q000528:radiation effects; D006321:Heart / Q000528:radiation effects; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008175:Lung Neoplasms / Q000532:radiotherapy*; D058958:Organs at Risk; D011879:Radiotherapy Dosage
keywords: DVCs; Dose–volume constraints; Hypofractionated; NSCLC; Toxicity