title: Pregnancy-related pharmacokinetic changes.
abstract: The pharmacokinetics of many drugs are altered by pregnancy. Drug distribution and protein binding are changed by pregnancy. While some drug metabolizing enzymes have an apparent increase in activity, others have an apparent decrease in activity. Not only is drug metabolism affected by pregnancy, but renal filtration is also increased. In addition, pregnancy alters the apparent activities of multiple drug transporters resulting in changes in the net renal secretion of drugs.
authors.affiliation: Cooperative Pharmacy Program, University of Texas, Rio Grande Valley TX and Renaissance Transplant Institute, Doctors Hospital at Renaissance, Edinburg, Texas, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Tasnif
authors.affiliation: College of Pharmacy, University of Texas at Austin, Austin, Texas, USA.
authors.forename: J
authors.initials: J
authors.lastname: Morado
authors.affiliation: Departments of Pharmacy and Obstetrics & Gynecology, University of Washington, Seattle, WA, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: Hebert
mesh_terms: D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010599:Pharmacokinetics; D011247:Pregnancy / Q000378:metabolism*; D011485:Protein Binding; D014018:Tissue Distribution
chemical_list: D026901:Membrane Transport Proteins; D004364:Pharmaceutical Preparations