title: The Influence of Probiotic Lactobacillus casei in Combination with Prebiotic Inulin on the Antioxidant Capacity of Human Plasma.
abstract: The aim of the present study was to assess whether probiotic bacteria Lactobacillus casei (4 × 10(8) CFU) influences the antioxidant properties of human plasma when combined with prebiotic Inulin (400 mg). Experiments were carried out on healthy volunteers (n = 32). Volunteers were divided according to sex (16 male and 16 female) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 weeks, at the end of the study. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activity, and the ferric reducing ability of plasma (FRAP) in human plasma were examined. The administration of synbiotics containing L. casei plus Inulin resulted in a significant increase in FRAP values (p = 0.00008) and CAT activity (p = 0.02) and an insignificant increase in SOD and GPx activity compared to controls. Synbiotics containing L. casei (4 × 10(8) CFU) with prebiotic Inulin (400 mg) may have a positive influence on human plasma antioxidant capacity and the activity of selected antioxidant enzymes.
authors.affiliation: Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Kleniewska
authors.affiliation: Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Hoffmann
authors.affiliation: Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Pniewska
authors.affiliation: Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.
authors.forename: Rafał
authors.identifier: 0000-0001-6784-453X
authors.initials: R
authors.lastname: Pawliczak
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis* / Q000737:chemistry; D002374:Catalase / Q000097:blood / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006801:Humans; D007444:Inulin / Q000494:pharmacology*; D007780:Lacticaseibacillus casei / Q000502:physiology*; D008297:Male; D056692:Prebiotics; D019936:Probiotics; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D058616:Synbiotics; D015854:Up-Regulation
chemical_list: D000975:Antioxidants; D005290:Ferric Compounds; D056692:Prebiotics; D007444:Inulin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase