title: Lipid Rafts Assemble Dynein Ensembles.
abstract: New work by Rai et al. identifies a novel mechanism regulating phagosome transport in cells: the clustering of dynein motors into lipid microdomains, leading to enhanced unidirectional motility. Clustering may be especially important for dynein, a motor that works most efficiently in teams.
authors.affiliation: Department of Physiology, University of Pennsylvania Perelman School of Medicine, 638A Clinical Research Building, 415 Curie Boulevard, PA 19104-6085, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Nirschl
authors.affiliation: Department of Physiology, University of Pennsylvania Perelman School of Medicine, 638A Clinical Research Building, 415 Curie Boulevard, PA 19104-6085, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Ghiretti
authors.affiliation: Department of Physiology, University of Pennsylvania Perelman School of Medicine, 638A Clinical Research Building, 415 Curie Boulevard, PA 19104-6085, USA. Electronic address: holzbaur@mail.med.upenn.edu.
authors.forename: Erika L F
authors.initials: ELF
authors.lastname: Holzbaur
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002460:Cell Line; D004398:Dyneins / Q000737:chemistry* / Q000378:metabolism; D006028:Glycosphingolipids / Q000302:isolation & purification / Q000494:pharmacology; D016547:Kinesins / Q000737:chemistry / Q000378:metabolism; D007893:Leishmania donovani / Q000737:chemistry; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008561:Membrane Fusion / Q000187:drug effects; D021962:Membrane Microdomains / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D010587:Phagocytosis / Q000187:drug effects; D010588:Phagosomes / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D006028:Glycosphingolipids; C008290:lipophosphonoglycan; D004398:Dyneins; D016547:Kinesins