title: Ultra-Porous Nanoparticle Networks: A Biomimetic Coating Morphology for Enhanced Cellular Response and Infiltration.
abstract: Orthopedic treatments are amongst the most common cause of surgery and are responsible for a large share of global healthcare expenditures. Engineering materials that can hasten bone integration will improve the quality of life of millions of patients per year and reduce associated medical costs. Here, we present a novel hierarchical biomimetic coating that mimics the inorganic constituent of mammalian bones with the aim of improving osseointegration of metallic implants. We exploit the thermally-driven self-organization of metastable core-shell nanoparticles during their aerosol self-assembly to rapidly fabricate robust, ultra-porous nanoparticle networks (UNN) of crystalline hydroxyapatite (HAp). Comparative analysis of the response of osteoblast cells to the ultra-porous nanostructured HAp surfaces and to the spin coated HAp surfaces revealed superior osseointegrative properties of the UNN coatings with significant cell and filopodia infiltration. This flexible synthesis approach for the engineering of UNN HAp coatings on titanium implants provides a platform technology to study the bone-implant interface for improved osseointegration and osteoconduction.
authors.affiliation: Nanotechnology Research Laboratory, Research School of Engineering, Australian National University, Canberra 2601, Australia.
authors.forename: Noushin
authors.initials: N
authors.lastname: Nasiri
authors.affiliation: Nanotechnology Research Laboratory, Research School of Engineering, Australian National University, Canberra 2601, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ceramidas
authors.affiliation: Laboratory of Advanced Biomaterials, Research School of Engineering, Australian National University, Canberra 2601, Australia.
authors.forename: Shayanti
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Laboratory of Advanced Biomaterials, Research School of Engineering, Australian National University, Canberra 2601, Australia.
authors.forename: Anitha
authors.initials: A
authors.lastname: Panneerselvan
authors.affiliation: Laboratory of Advanced Biomaterials, Research School of Engineering, Australian National University, Canberra 2601, Australia.
authors.forename: David R
authors.initials: DR
authors.lastname: Nisbet
authors.affiliation: Nanotechnology Research Laboratory, Research School of Engineering, Australian National University, Canberra 2601, Australia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Tricoli
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D002478:Cells, Cultured; D017886:Durapatite / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D016348:Osseointegration; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology*; D019736:Prostheses and Implants; D013499:Surface Properties
chemical_list: D017886:Durapatite