title: Characterization and application of chondroitin sulfate/polyvinyl alcohol nanofibres prepared by electrospinning.
abstract: Composite nanofibres were prepared by electrospinning from a solution of chondroitin sulfate and polyvinyl alcohol. The chondroitin sulfate/polyvinyl alcohol (CS/PVA) mass ratios of 7/3 has a uniform and smooth morphology, and the average diameter of the nanofibres was 136nm. Combretastatin A-4 phosphate was loaded on the nanofibres and used as a model for testing drug release from the nanofibres crosslinked with glutaric dialdehyde. The morphology and structure of the nanofibres was determined using scanning electron microscopy. In order to assess their possible application to tissue engineering scaffolds, the toxicity and cytocompatibility of the nanofibres were tested by methylthiazolydiphenyl-tetrazolium bromide assay.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 15 Northern Third Ring East Road, Beijing 100029, PR China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 15 Northern Third Ring East Road, Beijing 100029, PR China.
authors.forename: Huitong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 15 Northern Third Ring East Road, Beijing 100029, PR China.
authors.forename: Muhammad Yasir
authors.initials: MY
authors.lastname: Akram
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 15 Northern Third Ring East Road, Beijing 100029, PR China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Mu
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 15 Northern Third Ring East Road, Beijing 100029, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Nie
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 15 Northern Third Ring East Road, Beijing 100029, PR China. Electronic address: magp@mail.buct.edu.cn.
authors.forename: Guiping
authors.initials: G
authors.lastname: Ma
mesh_terms: D000818:Animals; D002460:Cell Line; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000633:toxicity; D003432:Cross-Linking Reagents / Q000737:chemistry; D004058:Diffusion; D055664:Electrochemical Techniques; D005453:Fluorescence; D005976:Glutaral / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry* / Q000633:toxicity; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000633:toxicity; D013267:Stilbenes / Q000737:chemistry; D013500:Surface Tension
chemical_list: D003432:Cross-Linking Reagents; D013267:Stilbenes; D011142:Polyvinyl Alcohol; D002809:Chondroitin Sulfates; C058728:fosbretabulin; D005976:Glutaral
keywords: Chondroitin sulfate; Electrospinning; Nanofibres