title: Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.
abstract: We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10(-6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02.
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Shimada-Sugimoto
authors.affiliation: Graduate School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology , Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Miyagawa
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Seik-Soon
authors.identifier: 0000-0002-6809-4731
authors.initials: SS
authors.lastname: Khor
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Omae
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Licht
authors.initials: L
authors.lastname: Toyo-Oka
authors.affiliation: Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University , Kanagawa, Japan.
authors.forename: Nagisa
authors.initials: N
authors.lastname: Sugaya
authors.affiliation: Department of Psychiatry, Shonan Kamakura General Hospital , Kanagawa, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Division for Environment, Health and Safety, The University of Tokyo , Tokyo, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.affiliation: Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University , Niigata, Japan.
authors.forename: Akinori
authors.identifier: 0000-0003-2508-9649
authors.initials: A
authors.lastname: Miyashita
authors.affiliation: Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University , Niigata, Japan.
authors.forename: Ryozo
authors.initials: R
authors.lastname: Kuwano
authors.affiliation: Panic Disorder Research Center, Warakukai Med. Corp. , Tokyo, Japan.
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Kaiya
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.affiliation: Department of Psychiatry, Institute of Medical Life Science, Graduate School of Medicine, Mie University , Mie, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tanii
authors.affiliation: Tokyo Metropolitan Matsuzawa Hospital , Tokyo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.affiliation: Department of Physical and Health Education, Graduate School of Education, The University of Tokyo , Tokyo, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki