title: Mesenchymal stem cells (MSCs) as skeletal therapeutics - an update.
abstract: Mesenchymal stem cells hold the promise to treat not only several congenital and acquired bone degenerative diseases but also to repair and regenerate morbid bone tissues. Utilizing MSCs, several lines of evidences advocate promising clinical outcomes in skeletal diseases and skeletal tissue repair/regeneration. In this context, both, autologous and allogeneic cell transfer options have been utilized. Studies suggest that MSCs are transplanted either alone by mixing with autogenous plasma/serum or by loading onto repair/induction supportive resorb-able scaffolds. Thus, this review is aimed at highlighting a wide range of pertinent clinical therapeutic options of MSCs in the treatment of skeletal diseases and skeletal tissue regeneration. Additionally, in skeletal disease and regenerative sections, only the early and more recent preclinical evidences are discussed followed by all the pertinent clinical studies. Moreover, germane post transplant therapeutic mechanisms afforded by MSCs have also been conversed. Nonetheless, assertive use of MSCs in the clinic for skeletal disorders and repair is far from a mature therapeutic option, therefore, posed challenges and future directions are also discussed. Importantly, for uniformity at all instances, term MSCs is used throughout the review.
authors.affiliation: Section of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, 54000, Lahore, Pakistan. hamid.pharmacy@pu.edu.pk.
authors.forename: Hamid
authors.initials: H
authors.lastname: Saeed
authors.affiliation: Section of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, 54000, Lahore, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ahsan
authors.affiliation: Section of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, 54000, Lahore, Pakistan.
authors.forename: Zikria
authors.initials: Z
authors.lastname: Saleem
authors.affiliation: Department of Bio-technology, Lahore College for Women University, Lahore, Pakistan.
authors.forename: Mehwish
authors.initials: M
authors.lastname: Iqtedar
authors.affiliation: Section of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, 54000, Lahore, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Islam
authors.affiliation: Section of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, 54000, Lahore, Pakistan.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Danish
authors.affiliation: Department of Biochemistry and Molecular Biology, University of the Southern Denmark, 5230, Odense, Denmark.
authors.forename: Asif Manzoor
authors.initials: AM
authors.lastname: Khan
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D044968:Regenerative Medicine / Q000379:methods*
keywords: Autologous; Bone fracture; Cartilage repair; Craniofacial; Infantile Hypo-phosphatasia; MSCs; Osteo-arthritis; Osteogenic imperfecta; Osteoporosis; Vertebral disc