title: Progressive change in sleep over multiple nights of intracranial EEG monitoring.
abstract: OBJECTIVE
  We evaluated changes to sleep structure during continuous intracranial EEG (icEEG) monitoring of epilepsy patients undergoing localization of the seizure onset area.
  
  
  METHODS
  We studied 28 adult epilepsy patients who underwent icEEG monitoring for a median of 12 nights. We used a metric calculated from relative delta power (RDP) to evaluate the emergence of sleep cycles for every night of monitoring. We further evaluated the effect of seizures and AEDs on trends in the RDP metric.
  
  
  RESULTS
  We observed oscillations corresponding to sleep cycles in the RDP time-series. There was a significant increasing trend in our RDP sleep metric over the course of monitoring. Seizures and AEDs did not significantly affect this trend.
  
  
  CONCLUSIONS
  The RDP metric increased during icEEG monitoring, independent of seizures and AEDs. This increase may be due to a number of factors and these factors appear to outweigh the effects of seizures and AEDs.
  
  
  CONCLUSIONS
  Our results indicate that sleep is not uniform during icEEG monitoring, rather there is a considerable increasing, multi-night change in sleep structure.
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Rasesh B
authors.initials: RB
authors.lastname: Joshi
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gaspard
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Irina I
authors.initials: II
authors.lastname: Goncharova
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Milena
authors.initials: M
authors.lastname: Pavlova
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Duckrow
authors.affiliation: Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Jason L
authors.initials: JL
authors.lastname: Gerrard
authors.affiliation: Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Spencer
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Hirsch
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: hitten.zaveri@yale.edu.
authors.forename: Hitten P
authors.initials: HP
authors.lastname: Zaveri
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology*; D055815:Young Adult
keywords: Epilepsy; Intracranial EEG; Sleep