title: Personalizing mechanical ventilation for acute respiratory distress syndrome.
abstract: Lung-protective ventilation with low tidal volumes remains the cornerstone for treating patient with acute respiratory distress syndrome (ARDS). Personalizing such an approach to each patient's unique physiology may improve outcomes further. Many factors should be considered when mechanically ventilating a critically ill patient with ARDS. Estimations of transpulmonary pressures as well as individual's hemodynamics and respiratory mechanics should influence PEEP decisions as well as response to therapy (recruitability). This summary will emphasize the potential role of personalized therapy in mechanical ventilation.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: S Clark
authors.initials: SC
authors.lastname: Berngard
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Beitler
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Malhotra
keywords: Acute respiratory distress syndrome (ARDS); acute lung injury; positive-pressure respiration; respiratory mechanics; ventilator-induced lung injury (VILI)