title: Extended antibiotic resistance in carbapenemase-producing Klebsiella pneumoniae: A case series.
abstract: Infections caused by carbapenemase-producing Klebsiella pneumoniae resistant to tigecycline, colistin, or aminoglycosides are a growing health concern. In our retrospective chart review, we noted increased resistance to colistin compared with tigecycline, despite limited prior use of colistin. This may affect the choice of presumptive antibiotics used in these hard to treat infections. Improved infection control and antimicrobial stewardship practices are essential to prevent the spread of these multidrug-resistant organisms.
authors.affiliation: Eastern Virginia Medical School, Norfolk, VA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Walker
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA. Electronic address: shankas@evms.edu.
authors.forename: Shivanjali
authors.initials: S
authors.lastname: Shankaran
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism*; D003091:Colistin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D012189:Retrospective Studies; D000078304:Tigecycline; D055815:Young Adult; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D000078304:Tigecycline; D001618:beta-Lactamases; C063912:carbapenemase; D008911:Minocycline; D003091:Colistin
keywords: Klebsiella pneumoniae; colistin; drug resistance