title: Muscular hypertrophy and atrophy in normal rats provoked by the administration of normal and denervated muscle extracts.
abstract: This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a different extract. These extracts were obtained from normal soleus muscle, denervated soleus, normal extensor digitorum longus, and denervated extensor digitorum longus. Following treatment, the soleus and extensor digitorum longus muscles were obtained for study under optic and transmission electron microscope; morphometric parameters and myogenic responses were also analyzed. The results demonstrated that the treatment with normal soleus muscle and denervated soleus muscle extracts provoked hypertrophy and increased myogenic activity. In contrast, treatment with extracts from the normal and denervated EDL had a different effect depending on the muscle analyzed. In the soleus muscle it provoked hypertrophy of type I fibers and increased myogenic activity, while in the extensor digitorum longus atrophy of the type II fibers was observed without changes in myogenic activity. This suggests that the muscular responses of atrophy and hypertrophy may depend on different factors related to the muscle type which could be related to innervation.
authors.affiliation: Department of Neurology, Reina Sofia University Hospital, Córdoba, Spain.|Maimonides Institute for Biomedical Research IMIBIC, Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Agüera
authors.affiliation: Department of Critical Care and Emergency, Reina Sofia University Hospital, Córdoba, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Castilla
authors.affiliation: Department of Morphological Sciences, Section of Histology, Faculty of Medicine and Nursing, University of Cordoba, Córdoba, Spain.|Maimonides Institute for Biomedical Research IMIBIC, Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain.
authors.forename: Evelio
authors.initials: E
authors.lastname: Luque
authors.affiliation: Department of Morphological Sciences, Section of Histology, Faculty of Medicine and Nursing, University of Cordoba, Córdoba, Spain.|Maimonides Institute for Biomedical Research IMIBIC, Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain.|Research Group in Muscle Regeneration, University of Cordoba, Córdoba, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Jimena
authors.affiliation: Department of Morphological Sciences, Section of Histology, Faculty of Medicine and Nursing, University of Cordoba, Córdoba, Spain.|Maimonides Institute for Biomedical Research IMIBIC, Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain.|Research Group in Muscle Regeneration, University of Cordoba, Córdoba, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Leiva-Cepas
authors.affiliation: Department of Morphological Sciences, Section of Histology, Faculty of Medicine and Nursing, University of Cordoba, Córdoba, Spain.|Maimonides Institute for Biomedical Research IMIBIC, Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Ruz-Caracuel
authors.affiliation: Department of Morphological Sciences, Section of Histology, Faculty of Medicine and Nursing, University of Cordoba, Córdoba, Spain. cm1peamj@uco.es.|Maimonides Institute for Biomedical Research IMIBIC, Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain.|Research Group in Muscle Regeneration, University of Cordoba, Córdoba, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Peña
mesh_terms: D000818:Animals; D001284:Atrophy / Q000503:physiopathology; D004195:Disease Models, Animal; D006984:Hypertrophy / Q000503:physiopathology; D046529:Microscopy, Electron, Transmission; D009121:Muscle Denervation; D024510:Muscle Development / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar