title: Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism.
abstract: Autism spectrum disorder (ASD) has been postulated to involve impaired neuronal cooperation in large-scale neural networks, including cortico-cortical interhemispheric circuitry. In the context of ASD, alterations in both peripheral and central auditory processes have also attracted a great deal of interest because these changes appear to represent pathophysiological processes; therefore, many prior studies have focused on atypical auditory responses in ASD. The auditory evoked field (AEF), recorded by magnetoencephalography, and the synchronization of these processes between right and left hemispheres was recently suggested to reflect various cognitive abilities in children. However, to date, no previous study has focused on AEF synchronization in ASD subjects. To assess global coordination across spatially distributed brain regions, the analysis of Omega complexity from multichannel neurophysiological data was proposed. Using Omega complexity analysis, we investigated the global coordination of AEFs in 3-8-year-old typically developing (TD) children (n = 50) and children with ASD (n = 50) in 50-ms time-windows. Children with ASD displayed significantly higher Omega complexities compared with TD children in the time-window of 0-50 ms, suggesting lower whole brain synchronization in the early stage of the P1m component. When we analyzed the left and right hemispheres separately, no significant differences in any time-windows were observed. These results suggest lower right-left hemispheric synchronization in children with ASD compared with TD children. Our study provides new evidence of aberrant neural synchronization in young children with ASD by investigating auditory evoked neural responses to the human voice.
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kurita
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.|Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kikuchi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshimura
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Hiraishi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Hasegawa
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Hirosawa
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Furutani
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Higashida
authors.affiliation: Department of Adaptive Machine Systems, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Mutou
authors.affiliation: Department of Adaptive Machine Systems, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Asada
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
mesh_terms: D001306:Auditory Pathways / Q000503:physiopathology; D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D001321:Autistic Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D013067:Speech Perception / Q000502:physiology*