title: Advance in spinal cord ischemia reperfusion injury: Blood-spinal cord barrier and remote ischemic preconditioning.
abstract: The blood-spinal cord barrier (BSCB) is the physiological and metabolic substance diffusion barrier between blood circulation and spinal cord tissues. This barrier plays a vital role in maintaining the microenvironment stability of the spinal cord. When the spinal cord is subjected to ischemia/reperfusion (I/R) injury, the structure and function of the BSCB is disrupted, further destroying the spinal cord homeostasis and ultimately leading to neurological deficit. Remote ischemic preconditioning (RIPC) is an approach in which interspersed cycles of preconditioning ischemia is followed by reperfusion to tissues/organs to protect the distant target tissues/organs against subsequent lethal ischemic injuries. RIPC is an innovation of the treatment strategies that protect the organ from I/R injury. In this study, we review the morphological structure and function of the BSCB, the injury mechanism of BSCB resulting from spinal cord I/R, and the effect of RIPC on it.
authors.affiliation: Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.
authors.forename: Qijing
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Anesthesiology, Liyuan Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430077, Hubei, China.
authors.forename: Jinxiu
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Anesthesiology, Liyuan Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430077, Hubei, China. Electronic address: yqj721103@sina.com.
authors.forename: Ji
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Anesthesiology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei, China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000818:Animals; D006801:Humans; D019194:Ischemic Preconditioning; D020760:Spinal Cord Ischemia / Q000517:prevention & control*
keywords: Blood–spinal cord barrier; Ischemia reperfusion injury; Remote ischemic preconditioning