title: Cardiovascular Effects of Shock and Trauma in Experimental Models. A Review.
abstract: Experimental models of human pathology are useful guides to new approaches towards improving clinical and surgical treatments. A systematic search through PubMed using the syntax (shock) AND (trauma) AND (animal model) AND (cardiovascular) AND ("2010/01/01"[PDat]: "2015/12/31"[PDat]) found 88 articles, which were reduced by manual inspection to 43 entries. These were divided into themes and each theme is subsequently narrated and discussed conjointly. Taken together, these articles indicate that valuable information has been developed over the past 5 years concerning endothelial stability, mesenteric lymph, vascular reactivity, traumatic injuries, burn and sepsis. A surviving interest in hypertonic saline resuscitation still exists.
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Rocha-e-Silva
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy; D002319:Cardiovascular System / Q000503:physiopathology*; D004195:Disease Models, Animal; D012151:Resuscitation / Q000379:methods; D012462:Saline Solution, Hypertonic; D018805:Sepsis / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D014947:Wounds and Injuries / Q000150:complications* / Q000503:physiopathology / Q000628:therapy
chemical_list: D012462:Saline Solution, Hypertonic