title: Ultrasound Effect on Cancerous versus Non-Cancerous Cells.
abstract: Previous studies have found that cancer cells whose metastatic potential is low are more vulnerable to mechanical stress-induced trauma to their cytoskeleton compared with benign cells. Because ultrasound induces mechanical stresses on cells and tissues, it is postulated that there may be a way to apply ultrasound to tumors to reduce their ability to metastasize. The difference between low-malignant-potential cancer cells and benign cells could be a result of their different responses to the mechanical stress insonation induced. This hypothesis was tested in vitro and in vivo. Low-malignant-potential cells were found to be more sensitive to insonation, resulting in a significantly higher mortality rate compared with that of benign cells, 89% versus 21%, respectively. This effect can be controlled by varying ultrasound parameters: intensity, duration, and duty cycle. Thus, the results presented in this study suggest the application of ultrasound to discriminate between benign and malignant cells.
authors.affiliation: Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Aharon
authors.initials: A
authors.lastname: Azagury
authors.affiliation: Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Eliz
authors.initials: E
authors.lastname: Amar-Lewis
authors.affiliation: Department of Chemical Engineering, Sami Shamoon College of Engineering, Beer-Sheva, Israel.
authors.forename: Yana
authors.initials: Y
authors.lastname: Yudilevitch
authors.affiliation: Department of Nuclear Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Carol
authors.initials: C
authors.lastname: Isaacson
authors.affiliation: Department of Nuclear Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Brenda
authors.initials: B
authors.lastname: Laster
authors.affiliation: Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: kost@bgu.ac.il.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kost
mesh_terms: D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D002470:Cell Survival; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology* / Q000628:therapy*; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009369:Neoplasms; D013314:Stress, Mechanical; D013997:Time Factors; D014464:Ultrasonic Therapy / Q000009:adverse effects*; D000069453:Ultrasonic Waves / Q000009:adverse effects*
keywords: Cancer cells; Cancer treatment strategy; In vivo experiments; Ultrasound; Ultrasound effect on biological membrane