title: Effects of Xuebijing injection on microcirculation in septic shock.
abstract: BACKGROUND
  This study was conducted to investigate whether Xuebijing injection can rectify the dysfunction of microcirculation in septic shock and assessed the microcirculatory parameters directly via orthogonal polarization spectral and software AVA 3.0.
  
  
  METHODS
  Anesthetized and mechanically ventilated beagle dogs were modeled for septic shock via lipopolysaccharide (LPS) intravenous injection. They were divided randomly into four groups, control group accepted operation only for jejunostomy and cystostomy; LPS group accepted operation and LPS intravenous injection; saline group accepted operation, LPS intravenous injection, and saline resuscitation; XBJ group accepted operation, LPS intravenous injection, saline resuscitation, and Xuebijing injection infusion. The MAP was recorded via right femoral artery catheterization, at the same time, the blood gas analysis was taken via that pathway at the set time points. ScvO2 was obtained via right jugular vein catheterization at the related time points. Microcirculatory parameters were recorded by orthogonal polarization spectral via the jejunum stoma, and the microcirculation image was analyzed via the software AVA 3.0 later.
  
  
  RESULTS
  Xuebijing injection improved microcirculation of the jejunum villus in canine model of septic shock induced by endotoxin, especially for the proportion of perfused vessels.
  
  
  CONCLUSIONS
  Based on the adequate fluid resuscitation, Xuebijing injection plays a helpful role of improving microcirculation in septic shock.
authors.affiliation: Department of Intensive Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Intensive Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Intensive Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Intensive Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China.
authors.forename: Jieyi
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Intensive Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China. Electronic address: wlgicu@outlook.com.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Ma
mesh_terms: D000818:Animals; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D007583:Jejunum / Q000098:blood supply* / Q000187:drug effects; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008833:Microcirculation / Q000187:drug effects*; D011897:Random Allocation; D012772:Shock, Septic / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; C549376:Xuebijing; C440499:lipopolysaccharide, Escherichia coli O111 B4
keywords: Microcirculation; Sepsis; Xuebijing