title: Is It Possible to Prevent Ovarian Hyperstimulation Syndrome by Gonadotropin-Releasing Hormone Agonist Triggering and Modified Luteal Support in Patients With Polycystic Ovarian Morphology?
abstract: BACKGROUND
  Gonadotropin-releasing hormone (GnRH) agonist triggering plus 1,500 IU human chorionic gonadotropin (hCG) supplementation protocol was previously claimed effective in reducing the ovarian hyperstimulation syndrome (OHSS) incidence in high responders.
  
  
  METHODS
  This retrospective study included women with polycystic ovarian (PCO) morphology who were at high risk of OHSS and were given the GnRH agonist trigger plus hCG luteal support protocol in a single center.
  
  
  RESULTS
  The mean peak estradiol level was 5,336 ± 2,341 (1,187 - 19,746) pg/mL. The mean number of follicles > 12 mm on the day of trigger was 22 ± 7 (9 - 51). A total of 88 cycles were undertaken. Sixty-three (71.5%) women underwent fresh embryo transfer. Fresh embryo transfer was canceled in 21 (23.8%) and embryo transfer was canceled in four (4.5%) women. The overall clinical pregnancy rate was 46.4% per started cycle. A total of 12 (13.6%) patients developed OHSS. "Freeze-all" policy did not attenuate OHSS in four patients, and three of these patients developed OHSS despite 1,500 IU hCG was not administered.
  
  
  CONCLUSIONS
  We conclude that OHSS may still occur with the use of a GnRH agonist trigger combined with low-dose hCG supplementation protocol in women with polycystic ovary syndrome (PCOS) or PCO morphology. Furthermore, we also conclude that "freeze-all" policy also will not completely eliminate OHSS development in high-risk women.
authors.affiliation: Private Novafertil IVF Centre, Konya, Turkey.
authors.forename: Ali Sami
authors.initials: AS
authors.lastname: Gurbuz
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Ruya
authors.initials: R
authors.lastname: Deveer
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Mert
authors.initials: M
authors.lastname: Kucuk
authors.affiliation: Private Novafertil IVF Centre, Konya, Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Ozcimen
authors.affiliation: Private Novafertil IVF Centre, Konya, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Incesu
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Sezen
authors.initials: S
authors.lastname: Koseoglu
keywords: GnRH agonist; GnRH agonist trigger hCG; OHSS; “Freeze-all” policy