title: Clinical relevance of using autofluorescence bronchoscopy and white light bronchoscopy in different types of airway lesions.
abstract: OBJECTIVE
  The aim of this study was to evaluate the sensitivity and specificity of autofluorescence bronchoscopy (AFB) according to the macroscopic appearance of airway lesions under white light bronchoscopy (WLB).
  
  
  METHODS
  The bronchoscopic findings of 708 patients, who were pathologically and clinically diagnosed with airway lesions and underwent both WLB and AFB, were analyzed.
  
  
  RESULTS
  We recruited 708 patients for this study, of which 336 (47.5%) had benign lesions; 300 and 254 benign lesions were detected by AFB (specificity, 89.3%) and WLB (specificity, 75.6%), respectively. In 372 (52.5%) patients with bronchiogenic carcinoma, 356 and 235 lesions were identified by AFB (sensitivity, 95.7%) and WLB (sensitivity, 63.2%), respectively. The sensitivity and specificity of AFB for diagnosing lung cancer were higher than those of WLB (P < 0.05). Moreover, AFB showed high sensitivity for detecting lung cancer in cases in which WLB revealed hyperplasia, infiltration, and stenosis (P < 0.05).
  
  
  CONCLUSIONS
  AFB combined with WLB could effectively improve the diagnosis of airway lesions.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yin-Peng
authors.initials: YP
authors.lastname: Li
authors.forename: Jiao
authors.initials: J
authors.lastname: Ma
authors.forename: Fang
authors.initials: F
authors.lastname: Shi
authors.forename: Dong-Fang
authors.initials: DF
authors.lastname: Zhao
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Li
authors.affiliation: Department of Respiration, School of Petroleum Clinical Medicine of Hebei Medical University, Langfang, China.
authors.forename: Yan-Zong
authors.initials: YZ
authors.lastname: Zhang
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000000981:diagnostic imaging* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001999:Bronchoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D061848:Optical Imaging / Q000379:methods