title: Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma.
abstract: Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy in the liver, which is associated with a poor prognosis. However, the molecular pathogenesis of iCCA remains unclear. RNA-Seq for tumor and para-tumor sample pairs enables the characterization of changes in the gene expression profiles of patients with iCCA. The present study analyzed RNA‑Seq data of seven iCCA para‑tumor and tumor sample pairs. Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the iCCA samples when compared with the matched para‑tumor samples. Furthermore, genes associated with the immune system, metabolism and metabolic energy were significantly downregulated in the iCCA tumor tissues, indicating that this is involved in the pathogenesis of iCCA. The present study aimed to elucidate the gene expression patterns associated with the tumorigenesis of iCCA by comparing tumor and normal tissues, in order to isolate novel diagnostic factors for iCCA.
authors.affiliation: Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Zong
mesh_terms: D001650:Bile Duct Neoplasms / Q000235:genetics* / Q000473:pathology; D001652:Bile Ducts / Q000378:metabolism / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000235:genetics* / Q000473:pathology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D020648:Peptide Elongation Factor 1 / Q000235:genetics*; D012269:Ribosomal Proteins / Q000235:genetics*; D015854:Up-Regulation
chemical_list: C503234:EEF1A2 protein, human; D008565:Membrane Proteins; C509768:PDZK1IP1 protein, human; D020648:Peptide Elongation Factor 1; D012269:Ribosomal Proteins; C076844:RPL41 protein, human