title: [Clozapine and the electronic cigarette; a case study].
abstract: Electronic cigarettes are becoming increasingly popular and therefore psychiatrists are being confronted more and more frequently by this relatively new phenomenon. We discuss the case of a patient who switched from traditional cigarettes to electronic cigarettes and thereupon had a significant increase in the clozapine serum level. The increased level led to considerable side-effects and, as a result, the patients clozapine dosage had to be reduced. In theory, a rise in the clozapine serum level is to be expected after such a switch. However, since electronic cigarettes have not been on the market for very long, psychiatrists need to be aware of the risks and dangers that can arise as a result of exceptionally high clozapine levels.
authors.forename: T S E
authors.initials: TS
authors.lastname: Nonner
authors.forename: S J
authors.initials: SJ
authors.lastname: Timmer
mesh_terms: D014150:Antipsychotic Agents; D003024:Clozapine / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D066300:Electronic Nicotine Delivery Systems / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy*; D012907:Smoking / Q000378:metabolism; D016540:Smoking Cessation
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine