title: Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves.
abstract: The quantized vibration of chemical bonds provides a way of detecting specific molecules in a complex tissue environment. Unlike pure optical methods, for which imaging depth is limited to a few hundred micrometers by significant optical scattering, photoacoustic detection of vibrational absorption breaks through the optical diffusion limit by taking advantage of diffused photons and weak acoustic scattering. Key features of this method include both high scalability of imaging depth from a few millimeters to a few centimeters and chemical bond selectivity as a novel contrast mechanism for photoacoustic imaging. Its biomedical applications spans detection of white matter loss and regeneration, assessment of breast tumor margins, and diagnosis of vulnerable atherosclerotic plaques. This review provides an overview of the recent advances made in vibration-based photoacoustic imaging and various biomedical applications enabled by this new technology.
authors.affiliation: Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Hui
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Evan H
authors.initials: EH
authors.lastname: Phillips
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Goergen
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Sturek
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute of Inflammation, Immunology and Infectious Diseases, West Lafayette, IN 47907, USA.
authors.forename: Ji-Xin
authors.initials: JX
authors.lastname: Cheng
keywords: Atherosclerosis; Intravascular photoacoustic; Lipid; Overtone absorption; Photoacoustic microscopy; Photoacoustic tomography; Tumor margin