title: Copper-Catalyzed Aza-Michael Addition of Aromatic Amines or Aromatic Aza-Heterocycles to α,β-Unsaturated Olefins.
abstract: A highly efficient and mild Cu-catalyzed conjugate addition reaction of aromatic amines and aromatic aza-heterocycles to α,β-unsaturated olefins is described. The transformation is promoted by 3-7 mol % of a Cu complex generated in situ from a mixture of inexpensive CuCl, a readily available phosphine or imidazolium salt, and KOt-Bu at ambient temperature. A wide range of β-amino sulfone, β-amino nitrile, and β-amino carbonyl compounds is efficiently and selectively synthesized in high yields (62-99%).
authors.affiliation: Department of Chemistry, Kwangwoon University , Seoul 01897, Republic Korea.
authors.forename: Seongcheol
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Kwangwoon University , Seoul 01897, Republic Korea.
authors.forename: Seongil
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Chemistry, Kwangwoon University , Seoul 01897, Republic Korea.
authors.forename: Gihyeon
authors.initials: G
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Kwangwoon University , Seoul 01897, Republic Korea.
authors.forename: Yunmi
authors.initials: Y
authors.lastname: Lee