title: The metabolic profile in early rheumatoid arthritis: a high prevalence of metabolic obesity.
abstract: The aim of the study was to compare the prevalence of metabolic syndrome (MetS) in early RA patients with age-gender-matched population controls focusing on the presence of MetS in different weight categories. The study group consisted of 91 consecutive patients with early RA and 273 age- and gender-matched controls subjects. MetS was diagnosed according to the National Cholesterol Education Program (NCEP-ATP III) criteria. Mean age in both groups was 52 years, and 72.5 % were female. The prevalence of MetS did not differ between the two groups (35.2 % in RA, 34.1 % in control group). Mean systolic blood pressure in the RA group was 137 mmHg, in control group 131 mmHg, P = 0.01, and diastolic blood pressure 85 versus 81 mmHg, respectively (P < 0.01). We found that 20 of 65 (30.8 %) of RA patients compared to 80 of 152 (52.6 %) of the control subjects with elevated blood pressure received antihypertensive treatment (P < 0.01). When comparing subgroups with normal BMI, the odds of having MetS (being metabolically obese) were higher among early RA subjects (OR 5.6, CI 1.3-23.8). Of the individual components of metabolic syndrome, we found increased prevalence of hypertension (OR 2.8, CI 1.3-6.0) and hyperglycemia (OR 2.9, CI 1.0-8.0) in the RA group. Recognition of abnormal metabolic status among normal-weight RA patients who have not yet developed CVD could provide a valuable opportunity for preventative intervention.
authors.affiliation: Department of Internal Medicine, University of Tartu, L. Puusepa 8, 51014, Tartu, Estonia. raili.muller@kliinikum.ee.|Internal Medicine Clinic of Tartu University Hospital, L. Puusepa 8, 51014, Tartu, Estonia. raili.muller@kliinikum.ee.
authors.forename: Raili
authors.initials: R
authors.lastname: Müller
authors.affiliation: Department of Internal Medicine, University of Tartu, L. Puusepa 8, 51014, Tartu, Estonia.|Internal Medicine Clinic of Tartu University Hospital, L. Puusepa 8, 51014, Tartu, Estonia.
authors.forename: Mart
authors.initials: M
authors.lastname: Kull
authors.affiliation: Department of Internal Medicine, University of Tartu, L. Puusepa 8, 51014, Tartu, Estonia.
authors.forename: Kaja
authors.initials: K
authors.lastname: Põlluste
authors.affiliation: Department of Internal Medicine, University of Tartu, L. Puusepa 8, 51014, Tartu, Estonia.|Internal Medicine Clinic of Tartu University Hospital, L. Puusepa 8, 51014, Tartu, Estonia.
authors.forename: Annika
authors.initials: A
authors.lastname: Aart
authors.affiliation: Department of Internal Medicine, University of Tartu, L. Puusepa 8, 51014, Tartu, Estonia.|Internal Medicine Clinic of Tartu University Hospital, L. Puusepa 8, 51014, Tartu, Estonia.
authors.forename: Triin
authors.initials: T
authors.lastname: Eglit
authors.affiliation: Department of Internal Medicine, University of Tartu, L. Puusepa 8, 51014, Tartu, Estonia.|Internal Medicine Clinic of Tartu University Hospital, L. Puusepa 8, 51014, Tartu, Estonia.
authors.forename: Margus
authors.initials: M
authors.lastname: Lember
authors.affiliation: Department of Internal Medicine, University of Tartu, L. Puusepa 8, 51014, Tartu, Estonia.|Internal Medicine Clinic of Tartu University Hospital, L. Puusepa 8, 51014, Tartu, Estonia.
authors.forename: Riina
authors.initials: R
authors.lastname: Kallikorm
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D001794:Blood Pressure / Q000502:physiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D015995:Prevalence
keywords: Early arthritis; Metabolic obesity; Metabolic syndrome; Rheumatoid arthritis