title: Child-Pugh, MELD, and ALBI scores for predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure.
abstract: OBJECTIVE
  Our study aimed to evaluate the discriminative abilities of Child-Pugh, model for end-stage liver disease (MELD), and albumin-bilirubin (ALBI) scores in predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure (ACLF).
  
  
  METHODS
  Cirrhotic patients with ACLF admitted between 2010 January and 2014 June were retrospectively reviewed. Areas under the receiver operating characteristic curves (AUROCs) with 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  One hundred patients were eligible for the Asia-Pacific Association for the Study of the Liver (APASL) criteria. AUROCs of Child-Pugh, MELD, and ALBI scores in predicting the in-hospital mortality was 0.63 (95%CI: 0.52-0.72, P = 0.05), 0.75 (95%CI: 0.65-0.83, P < 0.0001), and 0.53 (95%CI: 0.42-0.63, P = 0.69), respectively. Eighty-eight patients were eligible for the EASL/AASLD criteria. AUROCs of Child-Pugh, MELD, and ALBI scores in predicting the in-hospital mortality were 0.59 (95%CI: 0.48-0.69, P = 0.14), 0.57 (95%CI: 0.46-0.68, P = 0.26), and 0.57 (95%CI: 0.46-0.67, P = 0.29), respectively. There was no significant difference among them.
  
  
  CONCLUSIONS
  Child-Pugh, MELD, and ALBI scores might be ineffective in predicting the in-hospital mortality of cirrhosis with ACLF.
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.|b Postgraduate College , Dalian Medical University , Dalian , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.
authors.forename: Xingshun
authors.initials: X
authors.lastname: Qi
authors.affiliation: c Department of Digestion , General Hospital of Chengdu Military Command , Chengdu , China.|d Disease Preventive and Control Center , Chengdu Military Command , Chengdu , China.
authors.forename: Shanhong
authors.initials: S
authors.lastname: Tang
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.|b Postgraduate College , Dalian Medical University , Dalian , China.
authors.forename: Han
authors.initials: H
authors.lastname: Deng
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.|b Postgraduate College , Dalian Medical University , Dalian , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.|b Postgraduate College , Dalian Medical University , Dalian , China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ning
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.
authors.forename: Junna
authors.initials: J
authors.lastname: Dai
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.|e Postgraduate College , Liaoning University of Traditional Chinese Medicine , Shenyang , China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Hou
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.|e Postgraduate College , Liaoning University of Traditional Chinese Medicine , Shenyang , China.
authors.forename: Jiancheng
authors.initials: J
authors.lastname: Zhao
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.|e Postgraduate College , Liaoning University of Traditional Chinese Medicine , Shenyang , China.
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.affiliation: a Liver Cirrhosis Study Group, Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Guo
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D058625:End Stage Liver Disease / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D005260:Female; D006304:Health Status; D006305:Health Status Indicators; D017052:Hospital Mortality; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers
keywords: ACLF; ALBI; cirrhosis; mortality; prognosis