title: Successful treatment of hepatic oligometastases with stereotactic ablative radiotherapy and radiofrequency ablation in an anaplastic lymphoma kinase fusion-positive lung cancer patient.
abstract: Local ablative therapy with stereotactic ablative radiotherapy may improve survival in oncogene-addicted lung cancer patients with extracranial oligometastatic disease treated with targeted therapies. There is limited data on the use of radiofrequency ablation (RFA) in this same setting. We present a case of an anaplastic lymphoma kinase (ALK)-positive lung cancer patient with hepatic oligometastatic progression who was successfully treated with both stereotactic ablative radiation and RFA while continuing with an ALK inhibitor.
authors.affiliation: Department of Oncology Aarhus University Hospital Aarhus Denmark.
authors.forename: Britta
authors.initials: B
authors.lastname: Weber
authors.affiliation: Department of Radiation Oncology BC Cancer Agency Vancouver British Columbia Canada.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Radiology Island Health Victoria British Columbia Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Sobkin
authors.affiliation: Insight Genetics, Inc. Nashville Tennessee USA.
authors.forename: Stephan W
authors.initials: SW
authors.lastname: Morris
authors.affiliation: Insight Genetics, Inc. Nashville Tennessee USA.
authors.forename: David
authors.initials: D
authors.lastname: Hout
authors.affiliation: Department of Pathology Island Health Victoria British Columbia Canada.
authors.forename: Nicholas
authors.initials: N
authors.lastname: van der Westhuizen
authors.affiliation: Department of Functional Imaging BC Cancer Agency Vancouver British Columbia Canada.
authors.forename: R Petter
authors.initials: RP
authors.lastname: Tonseth
authors.affiliation: Department of Medical Oncology BC Cancer Agency Victoria British Columbia Canada.
authors.forename: David L
authors.initials: DL
authors.lastname: Saltman
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D061208:Pulsed Radiofrequency Treatment; D016634:Radiosurgery; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: Lung cancer; oligometastases; radiofrequency ablation; stereotactic ablative radiotherapy