title: Knowledge management in a waste based biorefinery in the QbD paradigm.
abstract: Shifting resource base from fossil feedstock to renewable raw materials for production of chemical products has opened up an area of novel applications of industrial biotechnology-based process tools. This review aims to provide a concise and focused discussion on recent advances in knowledge management to facilitate efficient and optimal operation of a biorefinery. Application of quality by design (QbD) and process analytical technology (PAT) as tools for knowledge creation and management at different levels has been highlighted. Role of process integration, government policies, knowledge exchange through collaboration, and use of databases and computational tools have also been touched upon.
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India. Electronic address: asrathore@biotechcmz.com.
authors.forename: Anurag S
authors.initials: AS
authors.lastname: Rathore
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India.
authors.forename: Viki R
authors.initials: VR
authors.lastname: Chopda
authors.affiliation: Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India.
authors.forename: James
authors.initials: J
authors.lastname: Gomes
mesh_terms: D019149:Bioreactors; D001709:Biotechnology / Q000379:methods* / Q000458:organization & administration; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D058436:Knowledge Management; D018505:Waste Management / Q000379:methods*
keywords: Biorefinery; Knowledge management; Process analytical technology; Quality by design