title: Omega-3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress.
abstract: There is controversy about fish-oil supplementation and oxidative damage. This ambiguity should be explored to elucidate its role as modulator of oxidative stress, especially during gestation and postnatal life. This is the objective of this study. One hundred ten pregnant women were divided in two groups: control group CT (400 mL/day of the control dairy drink); supplemented group FO (400 mL/day of the fish oil-enriched dairy drink (±400-mg EPA-DHA/day)). Different biomarkers of oxidative damage were determined in the mother's at enrolment, at delivery and at 2.5 and 4 months postpartum and newborns at delivery and at 2.5 months postpartum. Omega-3 LC-PUFA supplementation during pregnancy and lactation decreased plasma hydroperoxides especially in newborn at delivery (P = 0.001) and 2.5 months (P = 0.006), increased superoxide dismutase (SOD) and catalase (CAT) in mothers at delivery (P = 0.024 (SOD)) and after 2.5 months (P = 0.040 (CAT)) and in newborns at 2.5 months (P = 0.035 (SOD); P = 0.021 (CAT)). Also, supplementation increased α-tocoferol in mothers at 2.5 months (P = 0.030) and in umbilical cord artery (P = 0.039). Higher levels of CoQ10 were found in mothers at delivery (P = 0.039) as well as in umbilical cord vein (P = 0.024) and artery (P = 0.036). Our supplementation prevents the oxidative stress in the mother and neonate during the first months of postnatal life, being a potential preventive nutritional strategy to prevent functional alterations associated with oxidative stress that have an important repercussion for the neonate development in the early postnatal life.
authors.affiliation: Department of Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain.|Institute of Nutrition and Food Technology 'José Mataix', University of Granada, Granada, Spain.|Human Nutrition Ph.D. Program, University of Granada, Spain.
authors.forename: Naroa
authors.initials: N
authors.lastname: Kajarabille
authors.affiliation: Department of Neonatology, Hospital Materno Infantil Virgen de las Nieves, Granada, Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Hurtado
authors.affiliation: Gastroenterology and Pediatric Nutrition Unit, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas, Spain.|Department of Clinical Sciences, Universidad de Las Palmas de Gran Canaria, Spain.|CIBER OBN, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Peña-Quintana
authors.affiliation: Department of Neonatology, Hospital Materno Infantil Virgen de las Nieves, Granada, Spain.
authors.forename: Manuela
authors.initials: M
authors.lastname: Peña
authors.affiliation: Department of Neurophysiology, Hospital Materno Infantil Virgen de las Nieves, Granada, Spain.
authors.forename: Josefa
authors.initials: J
authors.lastname: Ruiz
authors.affiliation: Department of Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain.|Institute of Nutrition and Food Technology 'José Mataix', University of Granada, Granada, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Diaz-Castro
authors.affiliation: Gastroenterology and Pediatric Nutrition Unit, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas, Spain.
authors.forename: Yessica
authors.initials: Y
authors.lastname: Rodríguez-Santana
authors.affiliation: Department of Neonatology, Hospital Materno Infantil Virgen de las Nieves, Granada, Spain.
authors.forename: Estefania
authors.initials: E
authors.lastname: Martin-Alvarez
authors.affiliation: Department of Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain.|Institute of Nutrition and Food Technology 'José Mataix', University of Granada, Granada, Spain.
authors.forename: Magdalena
authors.initials: M
authors.lastname: López-Frias
authors.affiliation: Department Obstetrics and Gynecology, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Soldado
authors.affiliation: Research and Development Department, Lactalis Puleva, Granada, Spain.
authors.forename: Federico
authors.initials: F
authors.lastname: Lara-Villoslada
authors.affiliation: Department of Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain.|Institute of Nutrition and Food Technology 'José Mataix', University of Granada, Granada, Spain.
authors.forename: Julio J
authors.initials: JJ
authors.lastname: Ochoa
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007774:Lactation; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014451:Ubiquinone; C024989:coenzyme Q10; D024502:alpha-Tocopherol
keywords: antioxidant defence; docosahexaenoic acid (DHA); infant development; n-3 fatty acids; oxidative stress; pregnancy