title: Urinary metabolomic study of systemic lupus erythematosus based on gas chromatography/mass spectrometry.
abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous organ and system manifestations. In this study, urinary metabolic alterations related to SLE were investigated by performing gas chromatography/mass spectrometry (GC/MS) based metabolomics and multivariate statistical analysis. Patients with SLE and healthy controls could be clearly differentiated in view of the metabolic abnormity in urine. Among 70 identified endogenous metabolites, 23 metabolites were dramatically increased in SLE patients, which involved in several key metabolic pathways including energy metabolism, nucleotide metabolism, oxidative stress and gut-microbiome-derived metabolism. This noninvasive and GC/MS-based metabolomic technique is a promising and potent strategy for identifying novel biomarkers and understanding pathogenesis of SLE. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Clinical Pharmacology and Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China. yanbei_prp@126.com.
authors.forename: Bei
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Rheumatology and Immunology, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Clinical Pharmacology and Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Clinical Pharmacology and Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Rheumatology and Immunology, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China.
authors.forename: Cibo
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Rheumatology and Immunology, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Clinical Pharmacology and Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China.
authors.forename: Aixin
authors.initials: A
authors.lastname: Shi
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Weibin
authors.initials: W
authors.lastname: Zha
authors.affiliation: Department of Clinical Pharmacology and Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China.
authors.forename: Luyi
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Clinical Pharmacology and Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing Hospital, No. 1 Dahua Road, Beijing, 100730, China. huxinbjyy@126.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism / Q000652:urine; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism* / Q000652:urine*; D008297:Male; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: GC/MS; metabolomics; systemic lupus erythematosus; urine