title: Pulsed arterial spin labeling effectively and dynamically observes changes in cerebral blood flow after mild traumatic brain injury.
abstract: Cerebral blood flow is strongly associated with brain function, and is the main symptom and diagnostic basis for a variety of encephalopathies. However, changes in cerebral blood flow after mild traumatic brain injury remain poorly understood. This study sought to observe changes in cerebral blood flow in different regions after mild traumatic brain injury using pulsed arterial spin labeling. Our results demonstrate maximal cerebral blood flow in gray matter and minimal in the white matter of patients with mild traumatic brain injury. At the acute and subacute stages, cerebral blood flow was reduced in the occipital lobe, parietal lobe, central region, subcutaneous region, and frontal lobe. Cerebral blood flow was restored at the chronic stage. At the acute, subacute, and chronic stages, changes in cerebral blood flow were not apparent in the insula. Cerebral blood flow in the temporal lobe and limbic lobe diminished at the acute and subacute stages, but was restored at the chronic stage. These findings suggest that pulsed arterial spin labeling can precisely measure cerebral blood flow in various brain regions, and may play a reference role in evaluating a patient's condition and judging prognosis after traumatic brain injury.
authors.affiliation: Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Peng
authors.affiliation: Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Li
authors.affiliation: Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Jun
authors.identifier: 0000-0002-2900-0915
authors.initials: J
authors.lastname: Liu
authors.affiliation: Hunan Cancer Hospital, Changsha, Hunan Province, China.
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Zi-Shu
authors.initials: ZS
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Shun-Ke
authors.initials: SK
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Fang-Xu
authors.initials: FX
authors.lastname: Tao
authors.affiliation: Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Zhi-Xue
authors.initials: ZX
authors.lastname: Zhang
keywords: CT; Glasgow Coma Scale; MRI; cerebral blood flow; gray matter; mild traumatic brain injury; nerve regeneration; neural regeneration; pulsed arterial spin labeling technique; white matter