title: Genetic variation study of 12 X chromosomal STR in central Thailand population.
abstract: Genetic data from 12 short tandem repeats (STR) on the X chromosome are currently used in forensics studies to resolve issues related to complex kinship or when data is missing or ambiguous. In this study, we genotyped these 12 X chromosome STR in DNA collected from individuals from central Thailand (n = 391, 282 men and 109 women) and used this information to calculate allele and haplotype frequencies as well as forensic parameters for kinship calculations. Polymorphism information contents of the loci were range from 0.5283-0.9247, and powers of discrimination in females and males were 0.7666-0.9905 and 0.6085-0.9291, respectively. A diallelic pattern was observed at the locus DXS7132. Moreover, a comparison of genetic distance revealed a close relationship within Asian countries. Our results indicate that the X chromosomal short tandem repeat (X-STR) multiplex system provides highly informative genetic data and could be advantageous in forensic studies.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama4 road, Lumpini, Bangkok, 10330, Thailand. v_kornkiat@yahoo.com.|Forensic Serology and DNA, King Chulalongkorn Memorial Hospital, 1873 Rama4 road, Lumpini, Bangkok, 10330, Thailand. v_kornkiat@yahoo.com.
authors.forename: Kornkiat
authors.initials: K
authors.lastname: Vongpaisarnsin
authors.affiliation: Forensic Serology and DNA, King Chulalongkorn Memorial Hospital, 1873 Rama4 road, Lumpini, Bangkok, 10330, Thailand.
authors.forename: Achara
authors.initials: A
authors.lastname: Boonlert
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama4 road, Lumpini, Bangkok, 10330, Thailand.
authors.forename: Kawin
authors.initials: K
authors.lastname: Rasmeepaisarn
authors.affiliation: Forensic Serology and DNA, King Chulalongkorn Memorial Hospital, 1873 Rama4 road, Lumpini, Bangkok, 10330, Thailand.
authors.forename: Piyawan
authors.initials: P
authors.lastname: Dangkao
mesh_terms: D044466:Asian People / Q000235:genetics; D041321:Chromosomes, Human, X; D016172:DNA Fingerprinting; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D013785:Thailand
keywords: Central Thailand; Haplotype; Linkage disequilibrium; Short tandem repeat; X chromosome