title: Dengue fever in patients with multiple sclerosis taking fingolimod or natalizumab.
abstract: Dengue fever is the most prevalent mosquito-borne viral illness in humans. There may be different clinical manifestations of the disease, from mild symptoms to hemorrhagic forms of dengue fever and even neurological complications of this viral infection. Blood cells are usually affected, and thrombocytopenia is the hallmark of the disease. This paper presents 15 cases of dengue fever in patients with multiple sclerosis (MS) taking fingolimod or natalizumab. There were no complications of dengue fever or worse outcomes of MS in these patients, and only four of them needed short-term treatment withdrawal due to lymphopenia.
authors.affiliation: Department of Neurology, Universidade Metropolitana de Santos, Rua da Constituição 374, CEP 11015-470 Santos, SP, Brazil. Electronic address: yara@bsnet.com.br.
authors.forename: Yara Dadalti
authors.initials: YD
authors.lastname: Fragoso
authors.affiliation: Department of Neurology, Pontificia Universidade Catolica campus Sorocaba, Sorocaba, SP, Brazil.
authors.forename: Paulo Diniz da
authors.initials: PDD
authors.lastname: Gama
authors.affiliation: Department of Neurology, Hospital Beneficencia Portuguesa and Hospital Paulistano, Sao Paulo, SP, Brazil.
authors.forename: Sidney
authors.initials: S
authors.lastname: Gomes
authors.affiliation: Department of Neurology, Universidade Positivo, Curitiba, PR, Brazil.
authors.forename: Jussara Mathias Netto
authors.initials: JMN
authors.lastname: Khouri
authors.affiliation: Department of Neurology, Universidade Federal Fluminense, Niteroi, RJ, Brazil.
authors.forename: André Palma da Cunha
authors.initials: APDC
authors.lastname: Matta
authors.affiliation: Department of Neurology, Irmandade Santa Casa de Misericordia de Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: Fernanda Mendes
authors.affiliation: Department of Neurology, Private Clinic Campinas, Campinas, SP, Brazil.
authors.forename: Carla Renata Aparecida Vieira
authors.initials: CRAV
authors.lastname: Stella
mesh_terms: D000328:Adult; D001938:Brazil; D003715:Dengue / Q000150:complications* / Q000503:physiopathology; D005260:Female; D000068876:Fingolimod Hydrochloride / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D000069442:Natalizumab / Q000009:adverse effects / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D007155:Immunologic Factors; D000069442:Natalizumab; D000068876:Fingolimod Hydrochloride
keywords: Dengue fever; Fingolimod; Multiple sclerosis; Natalizumab