title: Assessment of Bone Mineral Density in Male Patients with Chronic Obstructive Pulmonary Disease by DXA and Quantitative Computed Tomography.
abstract: The purpose of this study is to identify the prevalence of osteoporosis in male patients with chronic obstructive pulmonary disease (COPD) by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) and to compare the diagnostic abilities of the above methods. Thirty-seven male patients with established COPD were examined with DXA and standard QCT in lumbar spine, including L1, L2, and L3 vertebrae. T-scores and bone mineral density values were calculated by DXA and QCT method, respectively. Comparative assessment of the findings was performed and statistical analysis was applied. QCT measurements found more COPD patients with impaired bone mineral density compared to DXA, namely, 13 (35.1%) versus 12 (32.4%) patients with osteopenia and 16 (43.2%) versus 9 (16.2%) patients with osteoporosis (p = 0.04). More vertebrae were found with osteoporosis by QCT compared to DXA (p = 0.03). The prevalence of osteoporosis among male patients with COPD is increased and DXA may underestimate this risk. QCT measurements have an improved discriminating ability to identify low BMD compared to DXA measurements because QCT is able to overcome diagnostic pitfalls including aortic calcifications and degenerative spinal osteophytes.
authors.affiliation: Department of Radiology, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Fountoulis
authors.affiliation: Pulmonology Clinic, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: Theodora
authors.initials: T
authors.lastname: Kerenidi
authors.affiliation: Department of Radiology, KAT Hospital, 14561 Athens, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Kokkinis
authors.affiliation: Department of Nuclear Medicine, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgoulias
authors.affiliation: Department of Radiology, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: Paschal
authors.initials: P
authors.lastname: Thriskos
authors.affiliation: Pulmonology Clinic, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gourgoulianis
authors.affiliation: Department of Radiology, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Fezoulidis
authors.affiliation: Department of Radiology, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Vassiou
authors.affiliation: Department of Radiology, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece.
authors.forename: Marianna
authors.identifier: 0000-0002-8104-9847
authors.initials: M
authors.lastname: Vlychou