title: Beta Blockade as Treatment for Intracranial Infantile Hemangioma: Case Report and Literature Review.
abstract: Intracranial infantile hemangiomas are extremely rare, with only 36 patients reported in literature. Treatment for intracranial infantile hemangiomas has been mostly limited to surgery, steroids, and interferon therapy. Propranolol, which is often used to treat cutaneous infantile hemangiomas, is not currently standard treatment for intracranial infantile hemangiomas.
  
  
  
  We present a one-month old boy with an intracranial infantile hemangioma treated with propranolol.
  
  
  
  This boy was being treated with oral propranolol for a supraclavicular infantile hemangioma. Subsequent brain magnetic resonance imaging (MRI) scan showed evidence of an associated intracranial infantile hemangioma in the right cerebellopontine angle. Repeat brain MRI scan after two months of propranolol treatment demonstrated a significant reduction in the size of the intracranial infantile hemangioma.
  
  
  
  This is the first report of successful therapy of an intracranial infantile hemangioma with propranolol.
authors.affiliation: School of Medicine, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Elise
authors.initials: E
authors.lastname: Kang
authors.affiliation: Center for Pediatric Neurology, Neurologic Institute and Cleveland Clinic Children's Hospital, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Neil
authors.initials: N
authors.lastname: Friedman
authors.affiliation: Pediatric and Neuroimaging, Cleveland Clinic Imaging Institute, Cleveland, Ohio.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Mamoun
authors.affiliation: Department of Pediatric Dermatology, Cleveland Clinic Children's Hospital, Cleveland, Ohio.
authors.forename: Joan
authors.initials: J
authors.lastname: Tamburro
authors.affiliation: Department of Pediatric Cardiology, Cleveland Clinic Children's Hospital, Cleveland, Ohio. Electronic address: goldena2@ccf.org.
authors.forename: Alex
authors.initials: A
authors.lastname: Golden
mesh_terms: D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006391:Hemangioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D000970:Antineoplastic Agents; D011433:Propranolol
keywords: beta blocker; capillary hemangioma; infantile hemangioma; intracranial; propranolol