title: Bioactive α-pyrone meroterpenoids from mangrove endophytic fungus Penicillium sp.
abstract: Five α-pyrone meroterpenoids, including one new 3-epiarigsugacin E (1) and four known compounds, arisugacin D (2), arisugacin B (3), territrem C (4) and terreulactone C (5) were obtained from the marine fungus Penicillium sp. SK5GW1L. Their structures were identified by MS and NMR experiments, and the absolute configuration of compound 1 was further confirmed by low temperature (150 K) single crystal X-ray diffraction with Cu Kα radiation. Compounds 3, 4 and 5 showed strong inhibitory activities against acetylcholinesterase (AchE) with IC50values of 3.03, 0.23 and 0.028 μM, respectively.
authors.affiliation: a School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou , China.|b Guangdong Inspection and Quarantine Technology Center , Guangdong Entry-Exit Inspection and Quarantine Bureau , Guangzhou , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ding
authors.affiliation: b Guangdong Inspection and Quarantine Technology Center , Guangdong Entry-Exit Inspection and Quarantine Bureau , Guangzhou , China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou , China.
authors.forename: Xishan
authors.initials: X
authors.lastname: Huang
authors.affiliation: a School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou , China.
authors.forename: Yayue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: b Guangdong Inspection and Quarantine Technology Center , Guangdong Entry-Exit Inspection and Quarantine Bureau , Guangzhou , China.
authors.forename: Wenrui
authors.initials: W
authors.lastname: Chen
authors.affiliation: a School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou , China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
keywords:  sp.; -pyrone meroterpenoids; acetylcholinesterase