title: Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma.
abstract: The purpose of this study was to characterize oncologic outcomes in early (T1-T2, N0) and intermediate (T1-T2, N1) oropharyngeal squamous cell carcinoma (SCC) after surgery.
  
  
  
  Patients with oropharyngeal SCC treated with surgery were identified from 2 academic institutions.
  
  
  
  Of 188 patients, 143 met the inclusion criteria. Eighty-six (60%) had T1 to T2 N0 and 57 (40%) had T1 to T2 N1 disease. Sixty-five patients (45%) underwent a robotic-assisted resection, whereas the remaining had transoral (n = 60; 42%), mandible-splitting (n = 11; 8%), or transhyoid approaches (n = 7; 5%). Human papillomavirus (HPV) status was known for 97 patients (68%), and 54 (55%) were HPV positive. Three-year recurrence-free survival (RFS) was 82% (95% confidence interval [CI] = 0.75-0.89). Since 2008, HPV infection was protective of recurrence (log-rank p = .0334). A single node did not increase the risk of recurrence (p = .467) or chance of a second primary (p = .175).
  
  
  
  Complete surgical resection is effective therapy for early and intermediate oropharyngeal SCC. HPV-negative patients were at increased risk for locoregional recurrence or second primary disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1471, 2016.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.|Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Jason I
authors.initials: JI
authors.lastname: Kass
authors.affiliation: Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Laureano
authors.initials: L
authors.lastname: Giraldez
authors.affiliation: Biostatistics Facility, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
authors.forename: William
authors.initials: W
authors.lastname: Gooding
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.
authors.forename: Garret
authors.initials: G
authors.lastname: Choby
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.
authors.forename: Seungwon
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Brett
authors.initials: B
authors.lastname: Miles
authors.affiliation: Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Marita
authors.initials: M
authors.lastname: Teng
authors.affiliation: Department of Otolaryngology, Baylor College of Medicine, Houston, Texas.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Sikora
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.
authors.forename: Jonas T
authors.initials: JT
authors.lastname: Johnson
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.
authors.forename: Eugene N
authors.initials: EN
authors.lastname: Myers
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.|Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania.
authors.forename: Umamaheswar
authors.initials: U
authors.lastname: Duvvuri
authors.affiliation: Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Genden
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania. ferrisrl@upmc.edu.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Ferris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: oncologic outcomes; oropharyngeal squamous cell carcinoma; transoral robotic surgery