title: Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children.
abstract: Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes, and the metabolic syndrome. Although steatosis is a key histologic feature, liver biopsies of patients with NAFLD can show a wide range of findings. Nonalcoholic steatohepatitis (NASH) is a progressive subtype of NAFLD first defined by analogy to alcoholic hepatitis. Young children may have an alternate pattern of progressive NAFLD characterized by a zone 1 distribution of steatosis, inflammation, and fibrosis. Several grading and staging systems exist, but all require adequate biopsies. Although NASH generally shows fibrosis progression over time, some patients show regression of disease.
authors.affiliation: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Building 10, Room 2S235, MSC 1500, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: kleinerd@mail.nih.gov.
authors.forename: David E
authors.initials: DE
authors.lastname: Kleiner
authors.affiliation: Cancer Diagnosis Program, Pathology Investigation and Resources Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Drive, Room 4W438, Bethesda, MD 20892, USA; Department of Pathology, Ain Shams University, Faculty of Medicine, 38 Al Abbassyah, Cairo, Greater Cairo 11566, Egypt.
authors.forename: Hala R
authors.initials: HR
authors.lastname: Makhlouf
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology*; D015588:Observer Variation
keywords: Histology; Liver biopsy; Scoring; Staging; Steatohepatitis; Steatosis