title: Adipose-Derived Stem Cell Delivery for Adipose Tissue Engineering: Current Status and Potential Applications in a Tissue Engineering Chamber Model.
abstract: In reconstructive surgery, there is a clinical need for adequate implants to repair soft tissue defects caused by traumatic injury, tumor resection, or congenital abnormalities. Adipose tissue engineering may provide answers to this increasing demand. This study comprehensively reviews current approaches to adipose tissue engineering, detailing different cell carriers under investigation, with a special focus on the application of adipose-derived stem cells (ASCs). ASCs act as building blocks for new tissue growth and as modulators of the host response. Recent studies have also demonstrated that the implantation of a hollow protected chamber, combined with a vascular pedicle within the fat flaps provides blood supply and enables the growth of large-volume of engineered soft tissue. Conceptually, it would be of value to co-regulate this unique chamber model with adipose-derived stem cells to obtain a greater volume of soft tissue constructs for clinical use. Our review provides a cogent update on these advances and details the generation of possible fat substitutes.
authors.affiliation: Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, NO1838, Guang Zhou North Road, Guangzhou, Guang Dong, People's Republic of China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Zhan
authors.affiliation: Section of Plastic, Reconstructive and Aesthetic Surgery, Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: Shaun S
authors.initials: SS
authors.lastname: Tan
authors.affiliation: Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, NO1838, Guang Zhou North Road, Guangzhou, Guang Dong, People's Republic of China. doctorlufeng@hotmail.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
mesh_terms: D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism; D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D015194:Diffusion Chambers, Culture; D006801:Humans; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D054457:Tissue Scaffolds
keywords: ASCs; Adipose tissue engineering; Biomaterial; Tissue engineering chamber model; Vascularization