title: Antenatal inflammation and gestational diabetes mellitus risk among pregnant African-American women.
abstract: Although inflammation is associated with risk of gestational diabetes mellitus (GDM), little is known if there is an association between inflammation and GDM in African-American women, a group at higher risk for GDM complications. In the present study, we aimed to determine if selected inflammatory cytokines (i.e. TNF-α, hs-CRP, IL-6, IL-10, IL-6/IL-10 ratio, IL-1β) measured in the 2nd trimester, were associated with GDM risk in 185 pregnant African-American women. GDM was defined as a physician-documented GDM diagnosis, a fasting glucose between 92 and 125mg/dl, or evidence of glucose intolerance (defined using the 3-h glucose tolerance test). A total of 18 women (9.7%) had GDM. After covariate adjustment, C-reactive protein, measured at a mean 21.2±3.7 weeks gestation, was statistically significantly associated with GDM development (P=0.025); for every one-unit increase in log-transformed C-reactive protein, the odds of GDM increased by 5.3. Results were similar using a principal component analysis approach. This study provides evidence that higher levels of 2nd trimester C-reactive protein is associated with increased risk of GDM in African-American women. Further research is needed to examine whether C-reactive protein may be a useful early-pregnancy screen for evaluating potential GDM risk in African-American women.
authors.affiliation: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Bossick
authors.affiliation: College of Nursing, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Rosalind M
authors.initials: RM
authors.lastname: Peters
authors.affiliation: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Burmeister
authors.affiliation: Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Naveen
authors.initials: N
authors.lastname: Kakumanu
authors.affiliation: Department of Endocrinology, Diabetes, and Bone and Mineral Disorders, Henry Ford Health System, Detroit, MI 48202, USA.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Shill
authors.affiliation: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA. Electronic address: acassid1@hfhs.org.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Cassidy-Bushrow
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D016207:Cytokines / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology* / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000276:immunology; D025341:Principal Component Analysis; D012306:Risk; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: African American; Gestational diabetes mellitus; Inflammation; hs-CRP