title: Cinnamomum camphora Seed Kernel Oil Improves Lipid Metabolism and Enhances β3-Adrenergic Receptor Expression in Diet-Induced Obese Rats.
abstract: The effects of dietary Cinnamomum camphora seed kernel oil (CCSKO) containing medium-chain triacylglycerols on lipid metabolism and mRNA and protein expression of β-3 adrenergic receptor in adipose tissue were studied in diet-induced obese rats. High fat food-induced obese rats were randomly divided into CCSKO group, Lard group, Soybean oil (SOY) group and naturally restoring group (n = 10). Rats fed with low fat food were used as a normal control group. Significant decreases in body mass and abdominal fat mass/body mass after 12 weeks were found in CCSKO group as compared with Lard and SOY groups (p < 0.05). Levels of blood total cholesterol (TC), triglyceride, free fatty acid, fasting insulin and insulin resistance in the CCSKO group were decreased significantly, and noradrenaline level and insulin sensitivity index in the CCSKO group were significantly higher than other groups. Meanwhile liver TC and triglyceride levels in the CCSKO group were also decreased markedly. Expression levels of β3-adrenergic receptor mRNA and protein were higher in CCSKO group than in Lard and SOY groups. These results suggest that CCSKO may contribute to reduction of the body fat mass, promote lipid metabolism and up-regulate β3-adrenergic receptor expression in high fat diet-induced obese rats.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
authors.affiliation: The First Clinical School, Nanchang University, Nanchang, 330031, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China. zlzengjx@163.com.|School of Environmental and Chemical Engineering, Nanchang University, Nanchang, 330031, China. zlzengjx@163.com.|Jiangxi Province Key Laboratory of Edible and Medicinal Plant Resources, Nanchang University, Nanchang, 330031, China. zlzengjx@163.com.
authors.forename: Zheling
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.
authors.forename: Baogui
authors.initials: B
authors.lastname: Wang
authors.affiliation: School of Environmental and Chemical Engineering, Nanchang University, Nanchang, 330031, China.
authors.forename: Xuefang
authors.initials: X
authors.lastname: Wen
authors.affiliation: School of Environmental and Chemical Engineering, Nanchang University, Nanchang, 330031, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.|Jiangxi Province Key Laboratory of Edible and Medicinal Plant Resources, Nanchang University, Nanchang, 330031, China.|School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
authors.forename: Deming
authors.initials: D
authors.lastname: Gong
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D027423:Cinnamomum camphora / Q000737:chemistry*; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D009765:Obesity / Q000139:chemically induced / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics* / Q000378:metabolism; D013024:Soybean Oil / Q000008:administration & dosage / Q000494:pharmacology; D015854:Up-Regulation
chemical_list: D004041:Dietary Fats; D010938:Plant Oils; D022702:Receptors, Adrenergic, beta-3; D013024:Soybean Oil; C029310:lard
keywords: Body fat; Cinnamomum camphora seeds kernel oil; Lipid metabolism; Medium-chain triacylglycerols; β-3 Adrenergic receptor