title: Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study.
abstract: We describe a rare multicentric neoplastic disease arising bilteraly in the kidney. The patient was a 70-year-old man, who, during a period of 3 years, was treated for five independent tumors of three histotypes (three multilocular cystic clear cell renal cell neoplasms of low malignant potential, one clear cell renal cell carcinoma, and one clear cell papillary renal cell carcinoma, respectively). Pathologic diagnosis of the reported tumors was confirmed by immunohistochemical analyses, including CD10, CA IX, CK7, AMACR/RACEMASE, and 34 beta E12. Molecular detection of KRAS, BRAF, NRAS, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET, and EGFR gene mutational analysis was also performed in all tumors.
authors.affiliation: Histopathology and Molecular Diagnostics, Universital Hospital Careggi, Florence, Italy.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Raspollini
authors.affiliation: Histopathology and Molecular Diagnostics, Universital Hospital Careggi, Florence, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Castiglione
authors.affiliation: Anatomic Pathology, Department of Pathology, University of Verona, Verona, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Martignoni
authors.affiliation: Department of Urology, Universital Hospital Careggi, Florence, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Lapini
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.affiliation: Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain.|Champalimaud Clinical Center, Lisbon, Portugal.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
keywords: 
  
  ALK
  
  ; 
  
  BRAF
  
  ; 
  
  EGFR
  
  ; 
  
  KRAS
  
  ; 
  
  NRAS
  
  ; 
  
  RET
  
  ; 
  DDR2
  ; 
  ERBB2
  ; 
  MAP2K1
  ; 
  PIK3CA
  ; Clear cell renal cell carcinoma; clear cell papillary renal cell carcinoma; kidney; molecular pathology; multilocular cystic clear cell renal cell neoplasm of low malignant potential