title: Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Previous Bone Marrow Stimulation Negatively Affect Clinical Outcome?
abstract: To determine if functional outcomes and magnetic resonance imaging (MRI) outcomes were significantly different between patients receiving primary autologous osteochondral transplantation (AOT) and patients receiving secondary AOT surgery after failed microfracture.
  
  
  
  A group of 76 patients enrolled into the Foot and Ankle Service between 2006 and 2012 was retrospectively analyzed. Patient-reported outcomes were evaluated in 76 patients using the Foot and Ankle Outcome Score (FAOS). Superficial and deep tissues at the repaired defect site, as well as the adjacent normal cartilage, were analyzed using quantitative T2 mapping MRI. Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) allowed for morphological evaluation of the repair tissue. The mean clinical follow-up time was 51 ± 23 months (range, 12 to 97 months), and the mean MRI follow-up time was 26 months (range, 24 to 36 months).
  
  
  
  Twenty-two patients received primary AOT and 54 received secondary AOT after failed microfracture. Patient characteristics between groups were similar with regard to age, gender, lesion size, and follow-up time. The mean postoperative FAOS was 10 points higher in the primary AOT group (83.2 ± 17.0) compared with the secondary AOT group (72.4 ± 19.4) (P = .01). Regression analysis showed that secondary AOT patients preoperative to postoperative change in FAOS was 9 points lower than in primary AOT patients after adjustment for age, preoperative FAOS, and lesion size (P = .045). The mean MOCART score, superficial T2 and deep T2 values, and the difference between normal and repair cartilage T2 values were not significantly different between groups. Lesion size was negatively correlated with MOCART scores (ρ = -0.2, P = .04), but positively correlated with difference in T2 values between repair and adjacent normal cartilage in the superficial layer (ρ = 0.3, P = .045).
  
  
  
  Primary AOT shows better functional outcomes compared with secondary AOT after failed microfracture in patients with similar characteristics and lesion size. No significant differences in T2 mapping relaxation times and MOCART scores were identified.
  
  
  
  Level III, case control study.
authors.affiliation: Department of Orthopedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, New York, New York, U.S.A.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Ross
authors.affiliation: Department of Orthopedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, New York, New York, U.S.A.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Murawski
authors.affiliation: Department of Orthopedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, New York, New York, U.S.A.
authors.forename: Ethan J
authors.initials: EJ
authors.lastname: Fraser
authors.affiliation: Department of Orthopedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, New York, New York, U.S.A.
authors.forename: Keir A
authors.initials: KA
authors.lastname: Ross
authors.affiliation: Department of Orthopedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, New York, New York, U.S.A.
authors.forename: Huong T
authors.initials: HT
authors.lastname: Do
authors.affiliation: Department of Orthopedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, New York, New York, U.S.A.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Deyer
authors.affiliation: Department of Orthopedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, New York, New York, U.S.A.. Electronic address: KennedyJ@HSS.EDU.
authors.forename: John G
authors.initials: JG
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D054544:Arthroplasty, Subchondral / Q000009:adverse effects*; D064592:Autografts; D002356:Cartilage / Q000293:injuries / Q000601:surgery* / Q000637:transplantation*; D016022:Case-Control Studies; D005260:Female; D005269:Femur / Q000637:transplantation*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D013628:Talus / Q000293:injuries / Q000601:surgery*