title: Low 25-hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children.
abstract: BACKGROUND
  Obesity is an important risk factor for non-alcoholic fatty liver disease. Few studies have evaluated the association between vitamin D and non-alcoholic fatty liver disease in obese children. Therefore, we conducted a study to examine the relationship of vitamin D levels and hepatosteatosis in obese children.
  
  
  METHODS
  One hundred and eleven children with obesity participated in this study. Hepatosteatosis was diagnosed and graded using ultrasonography in all patients. Study participants were divided based on the presence of hepatosteatosis into two subgroups (hepatosteatosis and non-hepatosteatosis). Serum levels of 25-hydroxyvitamin D, calcium, phosphate, alkaline phosphatase, parathormone, and lipids were measured and compared.
  
  
  RESULTS
  Hepatosteatosis existed in 52% of obese children without chronic diseases. There was no statistically significant difference in the vitamin D level between the hepatosteatosis and non-hepatosteatosis groups. Alanine aminotransferase levels and the triglycerides-to-high density lipoprotein ratio were significantly higher, and the high density lipoprotein levels were significantly lower in the hepatosteatosis group compared to the non-hepatosteatosis group.
  
  
  CONCLUSIONS
  Vitamin D deficiency is not directly related with hepatosteatosis. A high ALT level and a high triglycerides-to-HDL ratio and low HDL levels are more significant in hepatic steatosis in obese children.
authors.forename: Oya Balcı
authors.initials: OB
authors.lastname: Sezer
authors.forename: Derya
authors.initials: D
authors.lastname: Buluş
authors.forename: Şamil
authors.initials: Ş
authors.lastname: Hızlı
authors.forename: Nesibe
authors.initials: N
authors.lastname: Andıran
authors.forename: Deniz
authors.initials: D
authors.lastname: Yılmaz
authors.forename: Selma Uysal
authors.initials: SU
authors.lastname: Ramadan
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood*; D002648:Child; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology; D009752:Nutritional Status / Q000208:ethnology; D010044:Outpatient Clinics, Hospital; D050177:Overweight / Q000150:complications* / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology; D063766:Pediatric Obesity / Q000150:complications* / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014421:Turkey / Q000453:epidemiology; D014808:Vitamin D Deficiency / Q000150:complications* / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology
chemical_list: D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol