title: Live donor study - implications of kidney donation on cardiovascular risk with a focus on lipid parameters including lipoprotein a.
abstract: In this prospective observational cohort study, we evaluate the change in cardiovascular risk parameters, with a focus on lipids, in live kidney donors 1 year post donation. Body mass index, systolic/diastolic blood pressure, kidney function (chromium-51 ethylenediaminetetraacetic acid estimated glomerular filtration) and lipid parameters were measured at baseline and 1 year. Data on 87 live kidney donors were collected. Body mass index increased from 26.5 ± 2.7 pre to 27.4 ± 3.0 kg/m(2) post donation (p < 0.0001). Chromium-51 ethylenediaminetetraacetic acid estimated glomerular filtration decreased from 111.8 ± 20.0 pre to 72.1 ± 13.1 mL/min/1.73 m(2) post donation (p < 0.0001). Serum triglyceride levels increased from 0.8 (interquartile range 0.6-1.3) pre to 1.0 mmol/L (interquartile range 0.7-1.6) post donation (p = 0.0004). Statin use increased from 11.5% pre to 21% post donation (p < 0.005). Low-density lipoprotein remained stable, and other lipids (high-density lipoprotein, apolipoprotein B and lipoprotein a) did not change post donation.
authors.affiliation: Department of Cardiology, Mater Misericordiae Hospital, Brisbane, Queensland, Australia.|School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: Doucet
authors.affiliation: Department of Cardiology, Mater Misericordiae Hospital, Brisbane, Queensland, Australia.|School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Karam
authors.initials: K
authors.lastname: Kostner
authors.affiliation: Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors.forename: Omar
authors.initials: O
authors.lastname: Kaiser
authors.affiliation: School of Medicine, University of Queensland, Brisbane, Queensland, Australia.|Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.|Translational Research Institute, Brisbane, Queensland, Australia.|Australasian Kidney Trials Network, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Carmel
authors.initials: C
authors.lastname: Hawley
authors.affiliation: School of Medicine, University of Queensland, Brisbane, Queensland, Australia. nikky.isbel@health.qld.gov.au.|Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. nikky.isbel@health.qld.gov.au.
authors.forename: Nicole
authors.initials: N
authors.lastname: Isbel
mesh_terms: D000328:Adult; D001315:Australia / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008074:Lipoproteins / Q000378:metabolism*; D019520:Living Donors / Q000706:statistics & numerical data; D000069451:Long Term Adverse Effects / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects / Q000379:methods; D018570:Risk Assessment; D012307:Risk Factors; D020858:Tissue and Organ Harvesting / Q000009:adverse effects / Q000379:methods
chemical_list: D008074:Lipoproteins
keywords: Lp(a); cardiovascular risk; lipids; living donor transplantation; transplantation