title: The genome anatomy of Corynebacterium pseudotuberculosis VD57 a highly virulent strain causing Caseous lymphadenitis.
abstract: Corynebacterium pseudotuberculosis strain VD57 (Cp_VD57), a highly virulent, nonmotile, non-sporulating, and a mesophilic bacterium, was isolated from a goat's granulomatous lesion in the municipality of Juazeiro, Bahia State, Brazil. Here, we describe a set of features of the strain, together with the details of its complete genome sequence and annotation. The genome comprises of a 2.5 Mbp long, single circular genome with 2,101 protein-coding genes, 12 rRNA, 49 tRNA and 47 pseudogenes and a G + C content of 52.85 %. Genetic variation was detected in Cp_VD57 using C. pseudotuberculosis strain 1002 as reference, wherein small genomic insertions and deletions were identified. The comparative analysis of the genome sequence provides means to better understand the host pathogen interactions of this strain and can also help us to understand the molecular and genetic basis of virulence of this bacterium.
authors.affiliation: Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Sintia
authors.initials: S
authors.lastname: Almeida
authors.affiliation: Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Tiwari
authors.affiliation: Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Diego
authors.initials: D
authors.lastname: Mariano
authors.affiliation: Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Flávia
authors.initials: F
authors.lastname: Souza
authors.affiliation: Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Syed Babar
authors.initials: SB
authors.lastname: Jamal
authors.affiliation: Laboratory of Bioinformatics, Professional and Technological Education Sector, Federal University of Paraná, Curitiba, PR Brazil.
authors.forename: Nilson
authors.initials: N
authors.lastname: Coimbra
authors.affiliation: Laboratory of Bioinformatics, Professional and Technological Education Sector, Federal University of Paraná, Curitiba, PR Brazil.
authors.forename: Roberto Tadeu
authors.initials: RT
authors.lastname: Raittz
authors.affiliation: Aquacen - National Reference Laboratory for Aquatic Animal Diseases, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Fernanda Alves
authors.initials: FA
authors.lastname: Dorella
authors.affiliation: Aquacen - National Reference Laboratory for Aquatic Animal Diseases, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Alex Fiorine de
authors.initials: AF
authors.lastname: Carvalho
authors.affiliation: Aquacen - National Reference Laboratory for Aquatic Animal Diseases, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Felipe Luiz
authors.initials: FL
authors.lastname: Pereira
authors.affiliation: Aquacen - National Reference Laboratory for Aquatic Animal Diseases, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Siomar de Castro
authors.initials: Sde C
authors.lastname: Soares
authors.affiliation: Aquacen - National Reference Laboratory for Aquatic Animal Diseases, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Carlos Augusto Gomes
authors.initials: CA
authors.lastname: Leal
authors.affiliation: Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal India.
authors.forename: Debmalya
authors.initials: D
authors.lastname: Barh
authors.affiliation: Department of Computer Science, Virginia Commonwealth University, Richmond, VA USA.
authors.forename: Preetam
authors.initials: P
authors.lastname: Ghosh
authors.affiliation: Aquacen - National Reference Laboratory for Aquatic Animal Diseases, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Henrique
authors.initials: H
authors.lastname: Figueiredo
authors.affiliation: Institute of Health Sciences, Federal University of Bahia, Salvador, BA Brazil.
authors.forename: Lília Ferreira
authors.initials: LF
authors.lastname: Moura-Costa
authors.affiliation: Institute of Health Sciences, Federal University of Bahia, Salvador, BA Brazil.
authors.forename: Ricardo Wagner
authors.initials: RW
authors.lastname: Portela
authors.affiliation: Institute of Health Sciences, Federal University of Bahia, Salvador, BA Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Meyer
authors.affiliation: Institute of Biologic Sciences, Federal University of Para, Belem, PA Brazil.
authors.forename: Artur
authors.initials: A
authors.lastname: Silva
authors.affiliation: Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
authors.forename: Vasco
authors.initials: V
authors.lastname: Azevedo
keywords: Biovar ovis; Caseous lymphadenitis; Corynebacterium pseudotuberculosis; Genome sequencing; Goat; Gram-positive pathogen; Ion Torrent PGM