title: Multiple mechanisms of 3D migration: the origins of plasticity.
abstract: Cells migrate through 3D environments using a surprisingly wide variety of molecular mechanisms. These distinct modes of migration often rely on the same intracellular components, which are used in different ways to achieve cell motility. Recent work reveals that how a cell moves can be dictated by the relative amounts of cell-matrix adhesion and actomyosin contractility. A current concept is that the level of difficulty in squeezing the nucleus through a confining 3D environment determines the amounts of adhesion and contractility required for cell motility. Ultimately, determining how the nucleus controls the mode of cell migration will be essential for understanding both physiological and pathological processes dependent on cell migration in the body.
authors.affiliation: Department of Biology, Drexel University, United States. Electronic address: rjp336@drexel.edu.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Petrie
authors.affiliation: Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, United States.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Yamada
mesh_terms: D000205:Actomyosin / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D022081:Cell Surface Extensions / Q000378:metabolism; D017276:Friction; D006801:Humans; D058105:Polymerization
chemical_list: D000205:Actomyosin