title: Neuropsychological performance and affective temperaments in Euthymic patients with bipolar disorder type II.
abstract: Affective temperament has been suggested as a potential mediator of the effect between genetic predisposition and neurocognitive functioning. As such, this report seeks to assess the extent of the correlation between affective temperament and cognitive function in a group of bipolar II subjects. 46 bipolar II outpatients [mean age 41.4 years (SD 18.2); female 58.9%] and 46 healthy controls [mean age 35.1 years (SD 18); female 56.5%] were evaluated with regard to their demographic and clinical characteristics, affective temperament, and neurocognitive performance. Crude bivariate correlation analyses and multiple linear regression models were constructed between five affective temperament subscales and eight neurocognitive domains. Significant correlations were identified in bipolar patients between hyperthymic temperament and verbal memory and premorbid IQ; cyclothymic temperament and attention; and irritable temperament, attention, and verbal fluency. In adjusting for potential confounders of the relationship between temperament and cognitive function, the strongest mediating factors among the euthymic bipolar patients were found to be residual manic and depressive symptoms. It is therefore concluded that affective temperaments may partially influence the neurocognitive performance of both healthy controls and euthymic patients with bipolar disorder type II in several specific domains.
authors.affiliation: Department of Neuroscience, Research Center in Neuroscience and Neuropsychology, Palermo University, Buenos Aires, Argentina.
authors.forename: Ester
authors.initials: E
authors.lastname: Romero
authors.affiliation: Department of Neuroscience, Research Center in Neuroscience and Neuropsychology, Palermo University, Buenos Aires, Argentina,; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States.
authors.forename: Jessica N
authors.initials: JN
authors.lastname: Holtzman
authors.affiliation: Department of Neuroscience, Research Center in Neuroscience and Neuropsychology, Palermo University, Buenos Aires, Argentina.
authors.forename: Lucila
authors.initials: L
authors.lastname: Tannenhaus
authors.affiliation: Department of Neuroscience, Research Center in Neuroscience and Neuropsychology, Palermo University, Buenos Aires, Argentina.
authors.forename: Romina
authors.initials: R
authors.lastname: Monchablon
authors.affiliation: Department of Neuroscience, Research Center in Neuroscience and Neuropsychology, Palermo University, Buenos Aires, Argentina,; Dipartimento di Psicologia Clinica, Universitá La Sapienza, Roma, Italy.
authors.forename: Carlo Mario
authors.initials: CM
authors.lastname: Rago
authors.affiliation: Department of Neuroscience, Research Center in Neuroscience and Neuropsychology, Palermo University, Buenos Aires, Argentina,; National Council of Scientific and Technical Research (CONICET), Argentina.
authors.forename: Maria
authors.initials: M
authors.lastname: Lolich
authors.affiliation: Department of Neuroscience, Research Center in Neuroscience and Neuropsychology, Palermo University, Buenos Aires, Argentina,; International Consortium for Bipolar & Psychotic Disorder Research, McLean Hospital, Belmont, MA, United States. Electronic address: gvazquez@palermo.edu.
authors.forename: Gustavo H
authors.initials: GH
authors.lastname: Vázquez
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000523:psychology*; D000368:Aged; D001288:Attention; D001714:Bipolar Disorder / Q000523:psychology*; D016022:Case-Control Studies; D003071:Cognition; D003527:Cyclothymic Disorder / Q000523:psychology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007508:Irritable Mood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013694:Temperament
keywords: Affective disorder; Attention; Endophenotypes; Euthymia. Neurocognition; Planning; Premorbid IQ; Processing speed; Set shifting; Subsyndromal symptoms; Temperamental traits; Verbal fluency; Verbal memory; Visual memory; Working memory