title: Liraglutide in diabetes mellitus: More facts and findings.
abstract: Liraglutide exert favorable effects on most of the diabetes associated cardiovascular (CV) risk factors and this study was designed to further explore the benefits of liraglutide by observing its effect on plasma sialic acid (PSA) in diabetic rats. A total of 30 streptozotocin induced (50 mg/Kg; i.p.) diabetic rats were randomized into vehicle treated (1 ml/Kg s.c, twice daily) group I, liraglutide treated groups II and III (30 μg/Kg and 150 μg/Kg, twice daily respectively) and studied for 6 weeks. Liraglutide treated groups showed significant reductions in fructosamine levels (p≤0.05) from baseline. Between groups comparison revealed significant difference (p≤.05) at the end point. Similarly, at week 6, liraglutide treated groups showed significantly low levels of PSA compared to baseline (p<0.03 and p<0.005 for group II and III respectively) and control group I (p<0.002 and p<0.001 for group II and III respectively). However, the difference was non-significant between groups II and III (p<0.09). Other parameters including glucose tolerance, fasting plasma glucose (FPG), blood lipids, systolic blood pressure (SBP) and body weight also improved by liraglutide with the group III showing greater improvement. The study concludes that liraglutide produce favourable effects on PSA and may bea useful choice in protecting against diabetes associated CV complications.
authors.affiliation: Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan.
authors.forename: Inayat U
authors.initials: IU
authors.lastname: Rahman
authors.affiliation: Department of Pathology, Khyber Medical College, Peshawar, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Idrees
authors.affiliation: Department of Physiology, KIMS, Kohat, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bashir
authors.affiliation: Department of Chemistry, KUST, Kohat, Pakistan.
authors.forename: Mohammad Iqbal
authors.initials: MI
authors.lastname: Khan
authors.affiliation: Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan.
authors.forename: Naeem Ullah
authors.initials: NU
authors.lastname: Jan
authors.affiliation: Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Rahim
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D019270:Fructosamine / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D000069450:Liraglutide / Q000494:pharmacology*; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D051381:Rats; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D019270:Fructosamine; D000069450:Liraglutide; D019158:N-Acetylneuraminic Acid