title: Modeling drug passage into human milk.
abstract: Breastfeeding has positive health consequences for both the breastfed infant and the nursing mother.(1,2) Although information on drug use during lactation is available through sites such as LactMed,(3) available information is often incomplete. Unlike pregnancy, in which large numbers of pregnant women need to be studied to assure safety, measurement of drug concentrations in breastmilk in a relatively few subjects can provide valuable information to assess drug safety. This article reviews methods of measuring and predicting drug passage into breastmilk.
authors.affiliation: Health Sciences Clinical Professor, University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, California, USA.
authors.forename: P O
authors.initials: PO
authors.lastname: Anderson
authors.affiliation: Neonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Sauberan
mesh_terms: D001942:Breast Feeding; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007774:Lactation / Q000378:metabolism*; D008895:Milk, Human / Q000737:chemistry*; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011247:Pregnancy
chemical_list: D004364:Pharmaceutical Preparations