title: Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization.
abstract: Convenient methods were developed for copper-mediated oxidative C-H activation of aminoquinoline benzamides. The reaction conditions can be tuned to give either hydroxylation or dimerization compounds as the major products efficiently. Preliminary mechanistic studies suggested that different coordination states of copper may lead to different reaction outcomes.
authors.affiliation: Department of Natural Products Chemistry, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. sunxunf@shmu.edu.cn.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Wang
authors.affiliation: Roche Pharmaceutical Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China. yimin.hu@roche.com.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Natural Products Chemistry, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. sunxunf@shmu.edu.cn.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Roche Pharmaceutical Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China. yimin.hu@roche.com.
authors.forename: Hong C
authors.initials: HC
authors.lastname: Shen
authors.affiliation: Department of Natural Products Chemistry, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. sunxunf@shmu.edu.cn and Shanghai Key Laboratory of Clinical Geriatric Medicine, 221 West Yanan Road, Shanghai 200040, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Sun