title: q-Space Deep Learning: Twelve-Fold Shorter and Model-Free Diffusion MRI Scans.
abstract: Numerous scientific fields rely on elaborate but partly suboptimal data processing pipelines. An example is diffusion magnetic resonance imaging (diffusion MRI), a non-invasive microstructure assessment method with a prominent application in neuroimaging. Advanced diffusion models providing accurate microstructural characterization so far have required long acquisition times and thus have been inapplicable for children and adults who are uncooperative, uncomfortable, or unwell. We show that the long scan time requirements are mainly due to disadvantages of classical data processing. We demonstrate how deep learning, a group of algorithms based on recent advances in the field of artificial neural networks, can be applied to reduce diffusion MRI data processing to a single optimized step. This modification allows obtaining scalar measures from advanced models at twelve-fold reduced scan time and detecting abnormalities without using diffusion models. We set a new state of the art by estimating diffusion kurtosis measures from only 12 data points and neurite orientation dispersion and density measures from only 8 data points. This allows unprecedentedly fast and robust protocols facilitating clinical routine and demonstrates how classical data processing can be streamlined by means of deep learning.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Golkov
authors.forename: Alexey
authors.initials: A
authors.lastname: Dosovitskiy
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Sperl
authors.forename: Marion I
authors.initials: MI
authors.lastname: Menzel
authors.forename: Michael
authors.initials: M
authors.lastname: Czisch
authors.forename: Philipp
authors.initials: P
authors.lastname: Samann
authors.forename: Thomas
authors.initials: T
authors.lastname: Brox
authors.forename: Daniel
authors.initials: D
authors.lastname: Cremers
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D000069550:Machine Learning; D008279:Magnetic Resonance Imaging / Q000379:methods*; D016571:Neural Networks, Computer; D013997:Time Factors