title: Prediction of sacral neuromodulation treatment success in men with impaired bladder emptying-time for a new diagnostic approach.
abstract: Detrusor underactivity (DU) is currently a topic that receives major attention within functional urology. Urologists are often confronted with men who present with voiding dysfunction without bladder outlet obstruction (BOO) or after desobstructive or neuromodulation treatment. Their impaired bladder emptying is suspected to be related to failure of detrusor contractile function. Earlier research indicated that patients with non-obstructive urinary retention (NOR), for example, detrusor underactivity (DU), have a lower success rate after sacral neuromodulation (SNM) compared to patients treated with SNM for storage dysfunction. However, predicting factors for treatment success in the NOR group have not yet been defined.
  
  
  
  The aim of this study was to assess whether the use of the new BOO-contractility (Maastricht-Hannover) nomogram can identify and predict SNM non-responders. Our results in 18 men showed that only 20% of patients below the 10th percentile, but 86% of men between the 10 and 25th percentiles of the nomogram can be treated successfully with SNM. All successfully treated patients voided without needing self- catheterisation.
  
  
  
  This pilot study showed for the first time that SNM treatment response in male patients with impaired bladder emptying can be predicted with the BOO-contractility (Maastricht-Hannover) nomogram. Men below the 10th percentile are likely to be treatment non-responders, whereas the majority of men above the 10th percentile are responders. Neurourol. Urodynam. 36:808-810, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands.|FORCE Research Group Maastricht and Hannover.|School for Mental Health and Neuroscience MHeNs, Maastricht, The Netherlands.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Rademakers
authors.affiliation: Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands.|School for Mental Health and Neuroscience MHeNs, Maastricht, The Netherlands.
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Drossaerts
authors.affiliation: Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands.|School for Mental Health and Neuroscience MHeNs, Maastricht, The Netherlands.
authors.forename: Philip E
authors.initials: PE
authors.lastname: van Kerrebroeck
authors.affiliation: FORCE Research Group Maastricht and Hannover.|Department of Urology, Hannover Medical School, Hannover, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Oelke
authors.affiliation: Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands.|FORCE Research Group Maastricht and Hannover.|School for Mental Health and Neuroscience MHeNs, Maastricht, The Netherlands.
authors.forename: Gommert A
authors.initials: GA
authors.lastname: van Koeveringe
mesh_terms: D000328:Adult; D004599:Electric Stimulation Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D010865:Pilot Projects; D016896:Treatment Outcome; D001748:Urinary Bladder Neck Obstruction / Q000503:physiopathology / Q000628:therapy*; D016055:Urinary Retention / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics / Q000502:physiology*
keywords: detrusor underactivity; male LUTS; sacral neuromodulation; urodynamics; voiding dysfunction