title: Cerebral Metabolic Differences Associated with Cognitive Impairment in Parkinson's Disease.
abstract: OBJECTIVE
  To characterize cerebral glucose metabolism associated with different cognitive states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET).
  
  
  METHODS
  Three groups of patients were recruited in this study including PD patients with dementia (PDD; n = 10), with mild cognitive impairment (PD-MCI; n = 20), and with no cognitive impairment (PD-NC; n = 30). The groups were matched for age, sex, education, disease duration, motor disability, levodopa equivalent dose and Geriatric Depression Rating Scale (GDS) score. All subjects underwent a FDG-PET study. Maps of regional metabolism in the three groups were compared using statistical parametric mapping (SPM5).
  
  
  RESULTS
  PD-MCI patients exhibited limited areas of hypometabolism in the frontal, temporal and parahippocampal gyrus compared with the PD-NC patients (p < 0.01). PDD patients had bilateral areas of hypometabolism in the frontal and posterior parietal-occipital lobes compared with PD-MCI patients (p < 0.01), and exhibited greater metabolic reductions in comparison with PD-NC patients (p < 0.01).
  
  
  CONCLUSIONS
  Compared with PD-NC patients, hypometabolism was much higher in the PDD patients than in PD-MCI patients, mainly in the posterior cortical areas. The result might suggest an association between posterior cortical hypometabolism and more severe cognitive impairment. PD-MCI might be important for early targeted therapeutic intervention and disease modification.
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Tang
authors.affiliation: PET center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Fengtao
authors.initials: F
authors.lastname: Liu
authors.affiliation: PET center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Zhenyang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Zhengtong
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wu
authors.affiliation: PET center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
authors.forename: Chuantao
authors.initials: C
authors.lastname: Zuo
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan Universtiy, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000378:metabolism / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000209:etiology / Q000378:metabolism*; D003704:Dementia / Q000209:etiology / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007980:Levodopa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18; D007980:Levodopa