title: Longitudinal pattern of multiplexed immunoglobulin E sensitization from prenatal stage to the first year of life.
abstract: The longitudinal pattern of allergen-specific IgE levels from the prenatal stage to early life has remained largely unexplored.
  
  
  
  One-hundred and three mother-infant pairs, which were part of an ongoing population-based prospective birth cohort study of early childhood allergic diseases in Tainan, Taiwan, were included in this study. We examined the relationship of 20 allergen-specific IgE levels with blood samples of mothers, cord blood, and infants at 12 months of age using Spearman rank correlation, Kenal τ and McNemar test, respectively.
  
  
  
  Certain degree of IgE sensitization against most 20 examined specific allergens was observed in blood samples of mothers, cord blood, and infants at 12 months of age. When we further examined the association between allergy-related risk factors and atopy in infants at the first year of life, we found positive association between colic pain and atopy in infants at 12 months of age [adjusted odds ratios (AOR) = 3.51; 95% confidence interval (CI): 1.13-10.96; p = 0.03], and borderline significance between wheezing and atopy in infants at 12 months of age (AOR = 4.58; 95% CI: 0.89-23.50; p = 0.07).
  
  
  
  The findings from this study suggest that influence of maternal allergen-specific IgE levels on infant immune response might occur at birth and then wane in infants at 12 months of age. Positive association of colic pain and wheezing with atopy in infants at 12 months of age provides supportive evidence for the 'Allergy March' theory of allergy development in an Asian birth cohort.
authors.affiliation: Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Allergy and Clinical Immunology Research (ACIR) Center, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Jiu-Yao
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Allergy and Clinical Immunology Research (ACIR) Center, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Chih-Ann
authors.initials: CA
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Allergy and Clinical Immunology Research (ACIR) Center, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yung-I
authors.initials: YI
authors.lastname: Hou
authors.affiliation: Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Allergy and Clinical Immunology Research (ACIR) Center, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Wan-Lin
authors.initials: WL
authors.lastname: Hsiao
authors.affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Huang
authors.affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Tsai
authors.affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan.|Department of Public Health, China Medical University, Taichung, Taiwan.|Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Hui-Ju
authors.initials: HJ
authors.lastname: Tsai
mesh_terms: D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D007073:Immunoglobulin E
keywords: allergen-specific IgE; cord blood; first year of life; prenatal stage