title: IgA-dominant post-infectious glomerulonephritis; making another case in support of renal biopsy in type 2 diabetic nephropathy.
abstract: BACKGROUND
  Approximately one-third of individuals with type 2 diabetes mellitus will eventually develop diabetic nephropathy (DN). Impaired renal function in type 2 diabetics may also be secondary to non-diabetic renal disease (NDRD). NDRD in type 2 diabetics may occur alone in the absence of DN or may be superimposed on DN. Renal biopsy maybe indicated to establish the correct diagnosis and to ascertain the severity of glomerular and tubulointerstitial pathology.
  
  
  METHODS
  We report a patient with type 2 diabetes mellitus and chronic renal insufficiency who developed worsening of renal function in the setting of staphylococcal infection and antibiotic use.
  
  
  CONCLUSIONS
  Renal biopsy revealed IgA-dominant post-infectious glomerulonephritis and acute interstitial nephritis superimposed on diabetic glomerulosclerosis. Accumulating evidence indicates that, NDRD accounts for impaired renal function in a significant number of patients with type 2 diabetes mellitus. The presence of clinical, biochemical, and radiological features that suggest NDRD should prompt pathological evaluation of the kidney.
authors.affiliation: Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Nayer
authors.affiliation: Division of Nephrology and Hypertension, Allegheny Health Network, Temple University School of Medicine, Pittsburgh, PA, USA.
authors.forename: Gargi
authors.initials: G
authors.lastname: Davda
authors.affiliation: Division of Nephrology and Hypertension, Allegheny Health Network, Temple University School of Medicine, Pittsburgh, PA, USA.
authors.forename: Rima
authors.initials: R
authors.lastname: Pai
authors.affiliation: Division of Nephrology and Hypertension, Allegheny Health Network, Temple University School of Medicine, Pittsburgh, PA, USA.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Ortega
keywords: Diabetic nephropathy; Infectious glomerulonephritis; Non-diabetic renal disease; Staphylococcal infection