title: Ebi, a Drosophila homologue of TBL1, regulates the balance between cellular defense responses and neuronal survival.
abstract: Transducin β-like 1 (TBL1), a transcriptional co-repressor complex, is a causative factor for late-onset hearing impairments. Transcriptional co-repressor complexes play pivotal roles in gene expression by making a complex with divergent transcription factors. However, it remained to be clarified how co-repressor complex regulates cellular survival. We herein demonstrated that ebi, a Drosophila homologue of TBL1, suppressed photoreceptor cell degeneration in the presence of excessive innate immune signaling. We also showed that the balance between NF-κB and AP-1 is a key component of cellular survival under stress conditions. Given that Ebi plays an important role in innate immune responses by regulating NF-κB activity and inhibition of apoptosis induced by associating with AP-1, it may be involved in the regulation of photoreceptor cell survival by modulating cross-talk between NF-κB and AP-1.
authors.affiliation: Center for Development of Advanced Medicine for Dementia (CAMD), National Center for Geriatrics and Gerontology (NCGG), Obu Aichi, Japan.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Lim
authors.affiliation: Center for Development of Advanced Medicine for Dementia (CAMD), National Center for Geriatrics and Gerontology (NCGG), Obu Aichi, Japan.
authors.forename: Leo
authors.initials: L
authors.lastname: Tsuda
keywords: AP-1; Drosophila; NF-kappaB; Redox-dependent transcription factors; TBL1; ebi; innate immune signaling