title: Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography: A subgroup analysis of the Tryton IDE randomized trial.
abstract: OBJECTIVE
  Randomized comparison between the Tryton Side Branch Stent (Tryton Medical, Durham, NC), used in combination with a main branch drug-eluting stent (DES), and side branch balloon angioplasty (SBBA, in combination with a main branch DES) using intravascular ultrasound (IVUS), and three-dimensional quantitative coronary angiography (3D-QCA).
  
  
  BACKGROUND
  The Tryton stent has been developed to improve clinical outcomes after percutaneous coronary intervention (PCI) of bifurcation lesions.
  
  
  METHODS
  We present the pre-specified IVUS (n = 159) and 3D-QCA (n = 190) sub-group analyses of the Tryton coronary bifurcation trial (randomizing Tryton vs. SBBA).
  
  
  RESULTS
  There were no differences in the main branch with regard to minimal lumen area (MLA) (5.33 ± 1.37 in Tryton vs. 5.69 ± 1.72 mm2in SBBA, P = 0.235) with low neo-intima area in both groups. In the side branch, there were also no statistical significant differences between both groups (3.04 ± 1.02 in Tryton vs. 3.46 ± 1.15 mm2in SBBA, P = 0.072). On 3D-QCA, no differences in minimal lumen diameter (MLD) and percentage diameter stenosis (%DS) were observed in the proximal and distal main branches. In the side branch, there were also no differences found in %DS and MLD (MLD: 1.34 ± 0.043 mm [Tryton] vs. 1.45 ± 0.31 mm [SBBA], P = 0.090).
  
  
  CONCLUSIONS
  There were no differences in 9-month luminal dimensions of the side branch between the Tryton Stent and Side Branch Balloon Angioplasty, as assessed with IVUS (MLA) and 3D QCA (MLD). Angiographic and ultrasound results of the main branch were not negatively influenced by the Tryton stent. © 2016 Wiley Periodicals, Inc.
authors.affiliation: The Heartcenter, Academic Medical Center - University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Maik J
authors.initials: MJ
authors.lastname: Grundeken
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.|Cardialysis B.V, Rotterdam, Rotterdam, The Netherlands.
authors.forename: Hector M
authors.initials: HM
authors.lastname: Garcia-Garcia
authors.affiliation: Paul Stradins Clinical University Hospital, Riga, Latvia.
authors.forename: Indulis
authors.initials: I
authors.lastname: Kumsars
authors.affiliation: Karol Marcinkowski University of Medical Sciences, Poznan, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Lesiak
authors.affiliation: Universitair Ziekenhuis Leuven, Leuven, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Kayaert
authors.affiliation: Department of Cardiology, ZOL Ziekenhuis Oost-Limburg, Genk, Belgium.
authors.forename: Jo
authors.initials: J
authors.lastname: Dens
authors.affiliation: University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Pieter R
authors.initials: PR
authors.lastname: Stella
authors.affiliation: The Heartcenter, Academic Medical Center - University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: de Winter
authors.affiliation: Tryton Medical, Newton, Massachusetts.
authors.forename: Linda L
authors.initials: LL
authors.lastname: Laak
authors.affiliation: Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.|Columbia University Medical Center/NewYork Presbyterian Hospital, New York, New York.
authors.forename: Philippe
authors.initials: P
authors.lastname: Généreux
authors.affiliation: Tryton Medical, Newton, Massachusetts.|Dartmouth Medical School/Dartmouth-Hitchcock Medical Center, NH, Lebanon.
authors.forename: Aaron V
authors.initials: AV
authors.lastname: Kaplan
authors.affiliation: Columbia University Medical Center/NewYork Presbyterian Hospital, New York, New York.|Cardiovascular Research Foundation, New York, New York.
authors.forename: Martin B
authors.initials: MB
authors.lastname: Leon
authors.affiliation: The Heartcenter, Academic Medical Center - University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Joanna J
authors.initials: JJ
authors.lastname: Wykrzykowska
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.|Cardialysis B.V, Rotterdam, Rotterdam, The Netherlands.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.affiliation: International Centre for Circulatory Health, NHLI, Imperial College London, London, United Kingdom.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D054855:Drug-Eluting Stents; D005060:Europe; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011474:Prosthesis Design; D011857:Radiographic Image Interpretation, Computer-Assisted; D016037:Single-Blind Method; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional; D014481:United States
keywords: IVUS; TRYTON; coronary bifurcation lesion; side branch balloon angioplasty