title: Bone marrow amyloid spherulites in a case of AL amyloidosis.
abstract: Parallel arrangement of β-pleated sheets by amyloidogenic proteins is a well known phenomenon. Rarely, amyloid fibrils undergo radial orientation to form globular structures called spherulites. These amyloid spherulites show Maltese cross pattern under polarized microscopy. The clinical significance of amyloid spherulites is undetermined. Amyloidogenic proteins like insulin and β-lactoglobulin form spherulites in vitro. The senile plaques of Alzheimer's disease rarely form in vivo spherulites. Amyloid spherulites have been described in the liver and small intestine. For the first time, we document amyloid spherulite formation in the bone marrow biopsy of an AL amyloidosis patient.
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Karthik
authors.initials: K
authors.lastname: Bommannan B K
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Mukinkumar
authors.initials: M
authors.lastname: Sonai
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Man Updesh Singh
authors.initials: MU
authors.lastname: Sachdeva
mesh_terms: D000682:Amyloid / Q000648:ultrastructure*; D000686:Amyloidosis / Q000473:pathology*; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000682:Amyloid
keywords: Amyloid; Bone marrow; Spherulites