title: The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications.
abstract: Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammation, and autoimmune disorders. Radioprotective 105 kDa activates macrophages and B cells independently of canonical TLR signaling. Current understanding of the functional consequences of radioprotective 105 kDa signaling in B cells, macrophages, and dendritic cells indicates overlapping, but also some apparent opposing, cell-specific roles for radioprotective 105 kDa in shaping cellular functions. This review compares interactions of radioprotective 105 kDa with its coreceptors, CD19, TLR4, and TLR2; integrates recent, novel findings on radioprotective 105 kDa-mediated molecular signaling mechanisms; and summarizes current understanding of its contributions to infectious, inflammatory, and autoimmune disease.
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia; and.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Schultz
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia; and a.blumenthal@uq.edu.au.|Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Antje
authors.initials: A
authors.lastname: Blumenthal
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000503:physiopathology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D051193:Toll-Like Receptors
keywords: B cells; autoimmunity; infection; inflammation; macrophages