title: DNA Vaccination in Chickens.
abstract: Robust and sustainable development of poultry industry requires prevention of deadly infectious diseases. Vigorous vaccination of the birds is a routine practice; however, the live and inactivated vaccines that are used have inherent disadvantages. New-generation vaccines such as DNA vaccines offer several advantages over conventional vaccines. DNA vaccines, which encode an antigen of interest or multiple antigens in the target host, are stable, easy to produce and administer, do not require cold chain maintenance, and are not affected by the maternal antibodies. In addition, DNA vaccines can also be administered in ovo, and thus, mass vaccination and early induction of immune response can effectively be achieved. In this chapter, we focus on the development of DNA vaccines against important infectious viral as well as parasitic diseases of poultry.
authors.affiliation: Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India. shishirgupta.biotech@gmail.com.
authors.forename: Shishir Kumar
authors.initials: SK
authors.lastname: Gupta
authors.affiliation: Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India.
authors.forename: Sohini
authors.initials: S
authors.lastname: Dey
authors.affiliation: Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India.
authors.forename: Madhan Mohan
authors.initials: MM
authors.lastname: Chellappa
mesh_terms: D000818:Animals; D019556:COS Cells; D002645:Chickens / Q000276:immunology*; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D004274:DNA, Recombinant / Q000235:genetics; D005818:Genetic Engineering / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics; D057809:HEK293 Cells; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D010957:Plasmids / Q000235:genetics; D019444:Vaccines, DNA / Q000235:genetics* / Q000276:immunology*
chemical_list: D004274:DNA, Recombinant; D019444:Vaccines, DNA
keywords: Adjuvants; Chicken; DNA vaccine; New-generation vaccines; Poultry