title: Nucleoporins and chromatin metabolism.
abstract: Mounting evidence has implicated a group of proteins termed nucleoporins, or Nups, in various processes that regulate chromatin structure and function. Nups were first recognized as building blocks for nuclear pore complexes, but several members of this group of proteins also reside in the cytoplasm and within the nucleus. Moreover, many are dynamic and move between these various locations. Both at the nuclear envelope, as part of nuclear pore complexes, and within the nucleoplasm, Nups interact with protein complexes that function in gene transcription, chromatin remodeling, DNA repair, and DNA replication. Here, we review recent studies that provide further insight into the molecular details of these interactions and their role in regulating the activity of chromatin modifying factors.
authors.affiliation: Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
authors.forename: Christopher
authors.initials: C
authors.lastname: Ptak
authors.affiliation: Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7. Electronic address: rick.wozniak@ualberta.ca.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Wozniak
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004260:DNA Repair; D005057:Eukaryotic Cells / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*
chemical_list: D002843:Chromatin; D028861:Nuclear Pore Complex Proteins