title: Epigenetics in Drug Response.
abstract: Hereditary genetic variation has been identified to contribute significantly to drug response. More recently, there is increasing evidence that individual phenotypic differences may also result from epigenetic alterations such as histone-acetylation or DNA-methylation. Moreover, interactions with noncoding RNAs contribute to protein expression and may modulate drug action. Currently, intriguing developments of novel therapeutic approaches through epigenetic drugs are emerging. The overall complexity of epigenetics in drug action, however, is so far only little understood.
authors.affiliation: Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Cascorbi
authors.affiliation: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.|Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schwab
mesh_terms: D019175:DNA Methylation; D044127:Epigenesis, Genetic; D014644:Genetic Variation; D006657:Histones / Q000378:metabolism; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: D006657:Histones; D004364:Pharmaceutical Preparations; D022661:RNA, Untranslated