title: Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis.
abstract: Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53).
authors.affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, Miller School of Medicine, 1600 NW 10th Ave # 7060A, Miami, FL, 33136, USA. msm249@med.miami.edu.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mirsaeidi
authors.affiliation: Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Gidfar
authors.affiliation: Department of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Vu
authors.affiliation: Division of Pulmonary and Critical Care, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Schraufnagel
mesh_terms: D000818:Animals; D017302:Annexins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D011110:Polymorphism, Genetic; D011485:Protein Binding; D012507:Sarcoidosis / Q000209:etiology* / Q000378:metabolism*
chemical_list: D017302:Annexins
keywords: Annexin; Apoptosis; Calcium; Sarcoidosis