title: In vitro antimalarial and xanthine oxidase inhibition of 2-Aminoanthraquinone.
abstract: In the present research study 2-Aminoanthraquinone were scrutinized for their antimalarial and Xanthine oxidase inhibitor potential. It demonstrated marked concentration dependent antimalarial activity with maximum effect of 89.06% and with IC50 of 34.17 µM. Regarding Xanthine oxidase inhibitor activity, it evoked significant effect with 57.45% activity with IC50 value of 81.57.19 μM. In conclusion, 2-Aminoanthraquinone showed potent antimalarial and xanthine oxidase inhibitory activity.
authors.affiliation: Department of Geology, University of Swabi, Anbar, K.P.K, Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.affiliation: Department of Chemistry, University of Wah, The Mall, Quaid Avenue, Wah Cantt, Pakistan.
authors.forename: Rehan
authors.initials: R
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University Mardan, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Geology, University of Swabi, Anbar, K.P.K, Pakistan.
authors.forename: Noor
authors.initials: N
authors.lastname: Jehan
authors.affiliation: -
authors.forename: Mohammad
authors.initials: M
authors.lastname: Akram
authors.affiliation: Khyber Teaching Hospital, Peshawar, Peshawar, KPK, Pakistan.
authors.forename: Zarka
authors.initials: Z
authors.lastname: Ahmad
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University Mardan, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Muhammad
authors.affiliation: Department of Chemistry, COMSAT, Institute of Information Technology, Abbotabad, Pakistan.
authors.forename: Umar
authors.initials: U
authors.lastname: Farooq
authors.affiliation: Department of Chemistry, COMSAT, Institute of Information Technology, Abbotabad, Pakistan.
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010961:Plasmodium / Q000187:drug effects* / Q000254:growth & development; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000880:Anthraquinones; D000962:Antimalarials; D004791:Enzyme Inhibitors; C022970:2-aminoanthraquinone; D014969:Xanthine Oxidase