title: A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention.
abstract: A novel Janus device with omniphobic and mucoadhesive sides that exhibit the unique capacity for antifouling and extended gastrointestinal retention is fabricated. This system enables repulsion of the food and fluid stream by the luminal-facing omniphobic side and allows attachment to the gastrointestinal mucosa by the mucoadhesive side.
authors.affiliation: Department of Chemical Engineering and Koch Institute for Integrative Cancer, Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Young-Ah Lucy
authors.initials: YA
authors.lastname: Lee
authors.affiliation: Department of Chemical Engineering and Koch Institute for Integrative Cancer, Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Chemical Engineering and Koch Institute for Integrative Cancer, Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Chemical Engineering and Koch Institute for Integrative Cancer, Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Institute of Technology, Massachusetts, Cambridge, MA, 02139, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.affiliation: Department of Chemical Engineering and Koch Institute for Integrative Cancer, Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Traverso
mesh_terms: D000269:Adhesives / Q000378:metabolism*; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D009092:Mucous Membrane / Q000378:metabolism*; D013552:Swine; D014867:Water / Q000378:metabolism
chemical_list: D000269:Adhesives; D014867:Water
keywords: bioinspired; gastrointestinal retention; janus; mucoadhesive; omniphobic