title: Progression of primary open angle glaucoma in asymmetrically myopic eyes.
abstract: OBJECTIVE
  To compare progression of primary open angle glaucoma (POAG) in asymmetrically myopic eyes within the same subject and evaluate whether the degree of myopia is related to glaucoma progression.
  
  
  METHODS
  POAG patients with asymmetric myopia (axial length [AXL] ≥24 mm in both eyes, and the AXL difference between the right and left eyes to be ≥0.5 mm) were included. Glaucoma progression was determined either by optic disc/retinal nerve fiber layer (RNFL) photographs or by serial visual field (VF) data. The progression rates of VF mean deviation (dB/year) and spectral domain optical coherence tomography measured RNFL thickness (μm/year) were compared between the more myopic eye (MME) and the less myopic eye (LME) within the same subject.
  
  
  RESULTS
  A total of 55 patients (mean follow up period; 4.5 ± 1.0 years) were included. The mean AXL demonstrated a significant difference between MME and LME (26.3 ± 1.7 vs. 25.6 ± 1.7 mm; p = 0.036). The mean baseline VF MD (-3.8 ± 5.4 vs. -2.6 ± 4.7 dB; p = 0.21) and average RNFL thickness (77.5 ± 10.6 vs. 79.9 ± 12.3 μm; p = 0.36) did not differ between the MME and LME. Among the 55 patients, optic disc/RNFL photographic progression was noted in the MME in 15 patients, in the LME in 19 patients, and in both eyes in seven patients. VF progression was noted in the MME in seven patients, in the LME in seven patients, and in both eyes in four patients. The VF MD progression rates were -0.25 ± 0.34 dB/year in MME and -0.26 ± 0.34 dB/year in LME cases (p = 0.91). The mean progression rate of the average RNFL thickness also did not differ between the MME and LME (-0.59 ± 0.67 vs. -0.66 ± 0.72 μm/year, p = 0.68).
  
  
  CONCLUSIONS
  The degree of myopia was not associated with glaucoma progression when assessing the same patient using either the VF or optic disc/RNFL criteria in asymmetrically myopic patients.
authors.affiliation: Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Song
authors.affiliation: Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea. sungeye@gmail.com.
authors.forename: Kyung Rim
authors.initials: KR
authors.lastname: Sung
authors.affiliation: Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea.|Department of Applied Statistics, Gachon University, Seongnam-si, Gyeonggi-do, South Korea.
authors.forename: Seungbong
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Yoon
authors.affiliation: Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000000981:diagnostic imaging*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods; D014065:Tonometry, Ocular; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult
keywords: Glaucoma; Myopia; Optical coherence tomography; Perimetry; Progression; Visual field