title: Amyloidosis enhancing activity of bovine amyloid A fibrils in C3H/HeN mice and cynomolgus monkeys (Macaca fascicularis).
abstract: In experimentally induced cases of AA amyloidosis, the development of disease is enhanced by the administration of homogenous or heterogeneous amyloid fibrils. In recent years, cross-species transmission of animal amyloidosis into human has become of particular concern.
  
  
  
  Cynomolgus monkeys (Macaca fascicularis) and C3H/HeN mice were inoculated with bovine amyloid fibrils under acute inflammation.
  
  
  
  Amyloid A deposits were not detected in any of the monkeys, but mild-to-severe AA deposits were found in all mice.
  
  
  
  These results suggest that unlike in rodents, cross-species transmission of AA amyloidosis is less likely to develop, at least during acute inflammation, in primates.
authors.affiliation: Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Tsukawaki
authors.affiliation: Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Murakami
authors.affiliation: Department of Veterinary Medicine, Gifu University, Gifu, Japan.
authors.forename: Kanata
authors.initials: K
authors.lastname: Ibi
authors.affiliation: Amami Laboratory of Injurious Animals, The Institute of Medical Science, The University of Tokyo, Kagoshima, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kuraishi
authors.affiliation: Amami Laboratory of Injurious Animals, The Institute of Medical Science, The University of Tokyo, Kagoshima, Japan.
authors.forename: Shosaku
authors.initials: S
authors.lastname: Hattori
authors.affiliation: Amami Laboratory of Injurious Animals, The Institute of Medical Science, The University of Tokyo, Kagoshima, Japan.|Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Kai
authors.affiliation: Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Veterinary Medicine, Gifu University, Gifu, Japan.
authors.forename: Tokuma
authors.initials: T
authors.lastname: Yanai
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology; D000818:Animals; D002417:Cattle; D008252:Macaca fascicularis; D051379:Mice; D008809:Mice, Inbred C3H; D008992:Monkey Diseases / Q000209:etiology / Q000635:transmission*; D000685:Serum Amyloid A Protein / Q000378:metabolism
chemical_list: D000682:Amyloid; D000685:Serum Amyloid A Protein
keywords: amyloid A; cross-species transmission; experimental amyloidosis