title: Sinus mucosa elevation using Bio-Oss®or Gingistat®collagen sponge: an experimental study in rabbits.
abstract: OBJECTIVE
  To describe the sequential healing in augmented sinus cavities with deproteinized bovine bone mineral (DBBM) granules or collagen sponges.
  
  
  METHODS
  Twenty albino New Zealand rabbits were included in the study. An incision was performed along the midline of the nasal dorsum, and the nasal bone was exposed. Circular bony windows with a diameter of 5 mm were prepared bilaterally. After elevation of the mucosa, the two sites were randomly filled with either DBBM or a collagen sponge. Five animals each were randomly sacrificed after 7, 14, 21 and 40 days, respectively.
  
  
  RESULTS
  At both sides, new bone was found forming from the resident pristine bone. During the first stage of healing, DBBM granules were surrounded by a denser connective tissue that was attached to the biomaterial surface and that was progressively mineralized. At the collagen sponge side, the biomaterial was almost completely resorbed and the space was reduced by to two-thirds already after 21 days. At both sides, after 40 days, mineralized bone and marrow spaces were occupying large areas of the elevated space.
  
  
  CONCLUSIONS
  New bone was found forming from the pristine bony walls of the sinus and extending toward the most peripheral regions in both sites. While DBBM particles yielded osteoconductivity and were able to preserve over time the space within the elevated mucosa, the collagen sponge failed the goal of maintaining the space.
authors.affiliation: ARDEC Academy, Ariminum Odontologica, Rimini, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Caneva
authors.affiliation: Center for Dental Medicine, University of Zurich, Zurich, Switzerland.|University of Bern, Bern, Switzerland.
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.affiliation: UNESP - Faculdade de Odontologia de Araçatuba, UNESP - Universidade Estadual Paulista, São Paulo, Brazil.
authors.forename: Idelmo Junior
authors.initials: IJ
authors.lastname: Garcia Rangel
authors.affiliation: UNESP - Faculdade de Odontologia de Araçatuba, UNESP - Universidade Estadual Paulista, São Paulo, Brazil.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Ferreira
authors.affiliation: ARDEC Academy, Ariminum Odontologica, Rimini, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Caneva
authors.affiliation: ARDEC Academy, Ariminum Odontologica, Rimini, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: De Santis
authors.affiliation: ARDEC Academy, Ariminum Odontologica, Rimini, Italy.|UNESP - Faculdade de Odontologia de Araçatuba, UNESP - Universidade Estadual Paulista, São Paulo, Brazil.|POI - Programa Odontológico Internacional, Cartagena de Indias, Colombia.
authors.forename: Daniele
authors.initials: D
authors.lastname: Botticelli
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology*; D008903:Minerals / Q000494:pharmacology*; D010012:Osteogenesis; D011817:Rabbits; D059546:Sinus Floor Augmentation / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals; D003094:Collagen
keywords: animal study; collagen; deproteinized bovine bone mineral; sinus elevation