title: [Research Progress of a Novel Pro-apoptosis Gene PNAS-4 in Gene Therapy and Its Molecular Mechanism Hypotheses].
abstract: PNAS-4 is a novel pro-apoptosis gene identified latetly. In recent years, there has been a large number of research reports on the basic studies about PNAS-4 in cancer gene therapy and gene therapy of PNAS-4 alone or combined with chemotherapy or radiotherapy manifested a good application prospect, but its molecular mechanisms to promote apoptosis is not clear yet. In this paper, recent research about PNAS-4 in cancer gene therapy is briefly reviewed, and recent hypotheses on its molecular mechanisms to promote apoptosis are especially elucidated. Based on its newly identified characteristics of structural domain, we made a point that PNAS-4 might regulate functions of some target protein related to apoptosis by deSumoylation as a new deSumoylating isopeptidase, and consequently promote apoptosis.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D019759:Carbon-Nitrogen Lyases; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D058207:Sumoylation
chemical_list: D051017:Apoptosis Regulatory Proteins; D019759:Carbon-Nitrogen Lyases; C000604991:DESI2 protein, human