title: The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites.
abstract: Several recent studies have demonstrated the existence of membrane contact sites (MCS) between intracellular organelles in eukaryotic cells. Recent exciting studies have also demonstrated the existence of biomolecular interactions at these contact sites in mediating changes in the membrane composition of the cellular compartments. However, the role of such contact sites in regulating organelle function and physiological processes remains less clear. In this review we discuss the existence of a contact site between the plasma membrane (PM) and the endoplasmic reticulum (ER) inDrosophilaphotoreceptors. Further, we discuss the role of specific proteins present at this location in regulating phospholipid turnover and its impact in regulating a physiological process, namely phototransduction.
authors.affiliation: National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
authors.forename: Shweta
authors.initials: S
authors.lastname: Yadav
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College, London WC1E 6JJ, U.K.
authors.forename: Shamshad
authors.initials: S
authors.lastname: Cockcroft
authors.affiliation: National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India praghu@ncbs.res.in).
authors.forename: Padinjat
authors.initials: P
authors.lastname: Raghu
mesh_terms: D000818:Animals; D004330:Drosophila; D008954:Models, Biological; D017956:Photoreceptor Cells, Invertebrate / Q000378:metabolism*; D015398:Signal Transduction
keywords: 5)P2] turnover; 5-bisphosphate [PI(4; Drosophila; RDGB; lipid transfer proteins; membrane contact sites; micovillar photoreceptors; phosphatidylinositol 4