title: Aerosol-Based Cell Therapy for Treatment of Lung Diseases.
abstract: Aerosol-based cell delivery technique via intratracheal is an effective route for delivering transplant cells directly into the lungs. An aerosol device known as the MicroSprayer(®) Aerosolizer is invented to transform liquid into an aerosol form, which then can be applied via intratracheal administration for drug delivery. The device produces a uniform and concentrated distribution of aerosolized liquid. Using the capability of MicroSprayer(®) Aerosolizer to transform liquid into aerosol form, our group has designed a novel method of cell delivery using an aerosol-based technique. We have successfully delivered skin-derived fibroblast cells and airway epithelial cells into the airway of a rabbit with minimum risk of cell loss and have uniformly distributed the cells into the airway. This chapter illustrates the application of aerosol device to deliver any type of cells for future treatment of lung diseases.
authors.affiliation: Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Bandar Putra Bertam, 13200, Kepala Batas, Penang, Malaysia.
authors.forename: Egi
authors.initials: E
authors.lastname: Kardia
authors.affiliation: Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Bandar Putra Bertam, 13200, Kepala Batas, Penang, Malaysia.
authors.forename: Nur Shuhaidatul Sarmiza Abdul
authors.initials: NSSA
authors.lastname: Halim
authors.affiliation: Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Bandar Putra Bertam, 13200, Kepala Batas, Penang, Malaysia. badrul@usm.my.
authors.forename: Badrul Hisham
authors.initials: BH
authors.lastname: Yahaya
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000627:therapeutic use; D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004847:Epithelial Cells / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology / Q000628:therapy*; D009330:Nebulizers and Vaporizers; D011817:Rabbits
chemical_list: D000336:Aerosols
keywords: Aerosol delivery; Airway epithelial cells; Cell-based therapy; MicroSprayer® Aerosolizer; Skin-derived fibroblast