title: FGF23 as a calciotropic hormone.
abstract: Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol - 1,25(OH) 2D 3 - and induces phosphaturia. The consequences of a reduction in 1,25(OH) 2D 3 involve changes in calcium homeostasis. There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently, several studies have demonstrated that calcium also modulates FGF23 production. In a situation of calcium deficiency, the presence of 1,25(OH) 2D 3 is necessary to optimize intestinal absorption of calcium, and FGF23 is decreased to avoid a reduction in 1,25(OH) 2D 3 levels.
authors.affiliation: Laboratory of Nephrology, IIS-Fundación Jiménez Díaz, Madrid, Spain, 28040, Spain.
authors.forename: María E
authors.initials: ME
authors.lastname: Rodríguez-Ortiz
authors.affiliation: Nephrology Service and Maimónides Institute for Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Avda. Menéndez Pidal, S/N, 14004 Córdoba, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Rodríguez
keywords: FGF receptor; FGF23; calcium