title: [ROLE OF LEPTIN IN THE FORMATION OF SECONDARY AMENORRHEA IN ADOLESCENT GIRLS].
abstract: In order to understand the role of leptin in the formation of secondary amenorrhea (SA) during puberty, 78 girls aged from 13 to 17 years with SA and 74 girls of the same age with regular menstrual cycle have been examined with the estimation of body mass index (BMI) and hormonal/metabolic state. The obtained data show a strong connection between leptin level, BMI and parameters of energetic metabolic state (insulin; HOMA index); regression analysis results indicated the participation of leptin in steroidogenesis. Odds ratio (OR) values indicated an important role of leptin in the formation of SA during body weight deficit and normal BMI. It has been found that various clinical types of SA have different patterns of leptin influence.
authors.forename: S A
authors.initials: SA
authors.lastname: Levenets
authors.forename: T A
authors.initials: TA
authors.lastname: Nachotova
authors.forename: D A
authors.initials: DA
authors.lastname: Kashkalda
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000097:blood* / Q000145:classification / Q000503:physiopathology; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood; D016017:Odds Ratio; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000503:physiopathology; D011388:Prolactin / Q000097:blood; D011627:Puberty / Q000097:blood*
chemical_list: D007328:Insulin; D020738:Leptin; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone