title: A New Look at Toxicity in the Era of Precision Oncology: Imaging Findings, Their Relationship With Tumor Response, and Effect on Metastasectomy.
abstract: OBJECTIVE
  As cancer care becomes increasingly personalized and patients with metastatic disease live longer, oncologists' approach to drug toxicity is also evolving.
  
  
  CONCLUSIONS
  This article aims to broaden the radiologist's understanding of imaging-evident toxicity by describing how oncologists grade toxicity, exploring toxicity as a biomarker of treatment response, discussing the effect of toxicity in patients who are candidates for metastasectomy, and illustrating how combining drugs of varying classes amplifies toxicity.
authors.affiliation: 1 Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.|2 Brigham and Women's Hospital, Boston, MA.
authors.forename: Stephanie A Holler
authors.initials: SA
authors.lastname: Howard
authors.affiliation: 1 Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.|2 Brigham and Women's Hospital, Boston, MA.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Krajewski
authors.affiliation: 1 Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.|2 Brigham and Women's Hospital, Boston, MA.
authors.forename: Jyothi P
authors.initials: JP
authors.lastname: Jagannathan
authors.affiliation: 1 Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.|2 Brigham and Women's Hospital, Boston, MA.
authors.forename: Marta
authors.initials: M
authors.lastname: Braschi-Amirfarzan
authors.affiliation: 1 Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.|2 Brigham and Women's Hospital, Boston, MA.
authors.forename: Sree H
authors.initials: SH
authors.lastname: Tirumani
authors.affiliation: 1 Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.|2 Brigham and Women's Hospital, Boston, MA.
authors.forename: Atul B
authors.initials: AB
authors.lastname: Shinagare
authors.affiliation: 1 Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.|2 Brigham and Women's Hospital, Boston, MA.
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Ramaiya
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000032:analysis; D003952:Diagnostic Imaging; D006801:Humans; D008495:Medical Oncology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D057285:Precision Medicine
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: adverse events; biomarker; metastasectomy; toxicity