title: Dual Effects of Cellular Immunotherapy in Inhibition of Virus Replication and Prolongation of Survival in HCV-Positive Hepatocellular Carcinoma Patients.
abstract: Immune cells play an important role in the development and progression of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC). We conducted a retrospective study to evaluate the influence of adoptive cellular immunotherapy (CIT) on viral load and progression-free survival (PFS) for HCC patients infected with HCV. Patients (n = 104) were divided into a control group (conventional therapy, n = 73) and study group (combination of CIT and conventional therapy, n = 31). Autologous mononuclear cells were induced into natural killer, γδT, and cytokine-induced killer cells and infused intravenously to study group patients. More patients had shown viral load decrease or were stable in study group (100% versus 75%) (p = 0.014). The median PFS of the study group and control group was 16 and 10 months, respectively (p = 0.0041), and only CIT was an independent prognostic factor for PFS (hazard ratio, 0.422; p = 0.005). Three patients developed transient moderate fever after infusion, and there were no significant differences in alanine aminotransferase and aspartate aminotransferase levels before and after treatment in both groups. Our results show that CIT contributes to improvement of prognosis and inhibition of viral replication in HCV-related HCC patients, without impairment of liver function.
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Lei
authors.identifier: 0000-0002-0153-2717
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Nanya
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Tian
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Haofan
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Hengjun
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Niu
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Hua
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Tingwen
authors.initials: T
authors.lastname: Ge
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Jifan
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Fujun
authors.initials: F
authors.lastname: Han
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Jianting
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ding
authors.affiliation: Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Jiuwei
authors.initials: J
authors.lastname: Cui
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002454:Cell Differentiation; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D016174:Hepacivirus / Q000276:immunology / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology; D012189:Retrospective Studies; D016019:Survival Analysis; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D014182:Transplantation, Autologous; D019562:Viral Load; D014779:Virus Replication
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta