title: Adrenergic signaling in heart failure and cardiovascular aging.
abstract: Both cardiovascular disease and aging are associated with changes in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disorders, in particular heart failure. This article will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiovascular aging.
authors.affiliation: College of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA. Electronic address: gs2620@cumc.columbia.edu.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Santulli
authors.affiliation: Division of Internal Medicine, Department of Medicine and Surgery, University of Salerno, Italy. Electronic address: giaccarino@unisa.it.
authors.forename: Guido
authors.initials: G
authors.lastname: Iaccarino
mesh_terms: D000375:Aging / Q000378:metabolism*; D002319:Cardiovascular System / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism*; D011941:Receptors, Adrenergic / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000378:metabolism
chemical_list: D011941:Receptors, Adrenergic; D009638:Norepinephrine
keywords: Aging; Beta adrenergic receptors; Cardiovascular system; G protein-coupled receptor kinases; Heart failure; Multimorbidity; Sympathetic nervous system