title: Covalent Self-Assembly and One-Step Photocrosslinking of Tyrosine-Rich Oligopeptides to Form Diverse Nanostructures.
abstract: We present covalently self-assembled peptide hollow nanocapsule and peptide lamella. These biomimetic dityrosine peptide nanostructures are synthesized by one-step photopolymerization of a tyrosine-rich short peptide without the aid of a template. This simple approach offers direct synthesis of fluorescent peptide nanocages and free-standing thin films. The simple crosslinked peptide lamella films provide robust mechanical properties with an elastic modulus of approximately 30 GPa and a hardness of 740 MPa. These nanostructures also allow for the design of peptidosomes. The approach taken here represents a rare example of covalent self-assembly of short peptides into nano-objects, which may be useful as microcompartments and separation membranes.
authors.affiliation: National Centre of Applied Microfluidic Chemistry, Department of Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, Republic of Korea.
authors.forename: Kyoung-Ik
authors.initials: KI
authors.lastname: Min
authors.affiliation: Center for Self-Assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 790-784, Republic of Korea.
authors.forename: Gyeongwon
authors.initials: G
authors.lastname: Yun
authors.affiliation: Center for Self-Assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 790-784, Republic of Korea.|Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, Republic of Korea.
authors.forename: Yoonjung
authors.initials: Y
authors.lastname: Jang
authors.affiliation: National Centre of Applied Microfluidic Chemistry, Department of Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, Republic of Korea.
authors.forename: Kyung-Rok
authors.initials: KR
authors.lastname: Kim
authors.affiliation: Center for Self-Assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 790-784, Republic of Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Ko
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Hyung-Seok
authors.initials: HS
authors.lastname: Jang
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Yoon-Sik
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Center for Self-Assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 790-784, Republic of Korea.|Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, Republic of Korea.
authors.forename: Kimoon
authors.initials: K
authors.lastname: Kim
authors.affiliation: National Centre of Applied Microfluidic Chemistry, Department of Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, Republic of Korea. dpkim@postech.ac.kr.
authors.forename: Dong-Pyo
authors.initials: DP
authors.lastname: Kim
keywords: covalent self-assembly; films; nanocapsules; peptides; tyrosine-tyrosine crosslinking