title: The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis.
abstract: MicroRNAs are involved in many cellular and molecular activities and played important roles in many biological and pathological processes, such as tissue formation, cancer development, diabetes, neurodegenerative diseases, and cardiovascular diseases. Recently, it has been reported that microRNAs can modulate the differentiation and activities of osteoblasts and osteoclasts, the key cells that are involved in bone remodeling process. Meanwhile, the results from our and other research groups showed that the expression profiles of microRNAs in the serum and bone tissues are significantly different in postmenopausal women with or without fractures compared to the control. Therefore, it can be postulated that microRNAs might play important roles in bone remodeling and that they are very likely to be involved in the pathological process of postmenopausal osteoporosis. In this review, we will present the updated research on the regulatory roles of microRNAs in osteoblasts and osteoclasts and the expression profiles of microRNAs in osteoporosis and osteoporotic fracture patients. The perspective of serum microRNAs as novel biomarkers in bone loss disorders such as osteoporosis has also been discussed.
authors.affiliation: Department of Spine Surgery, Shenzhen People's Hospital, Jinan University School of Medicine, Shenzhen 518020, China; Department of Orthopaedics and Traumatology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong; Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Mengge
authors.initials: M
authors.lastname: Sun
authors.affiliation: Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Shishu
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics and Traumatology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong.
authors.forename: Victor
authors.initials: V
authors.lastname: Leung
authors.affiliation: Department of Orthopedic Surgery, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.affiliation: Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Haobo
authors.initials: H
authors.lastname: Pan
authors.affiliation: Department of Spine Surgery, Shenzhen People's Hospital, Jinan University School of Medicine, Shenzhen 518020, China.
authors.forename: Wanxin
authors.initials: W
authors.lastname: Zhen
authors.affiliation: Department of Orthopaedics and Traumatology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong; Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: William
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Spine Surgery, Shenzhen People's Hospital, Jinan University School of Medicine, Shenzhen 518020, China; Department of Orthopaedics and Traumatology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong; Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Peng
mesh_terms: D015415:Biomarkers; D016723:Bone Remodeling / Q000235:genetics*; D001842:Bone and Bones / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology; D010024:Osteoporosis / Q000235:genetics* / Q000473:pathology
chemical_list: D015415:Biomarkers; D035683:MicroRNAs