title: Bioenergetic roles of mitochondrial fusion.
abstract: Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidence in detailing their role in mitochondrial metabolism. Remarkably, mitofusin 2, in addition to its role in fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway. Here, we review the bioenergetic roles of mitochondrial dynamics and emphasize the importance of the in vitro growth conditions when evaluating mitochondrial respiration. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016,' edited by Prof. Paolo Bernardi.
authors.affiliation: Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Silva Ramos
authors.affiliation: Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.
authors.forename: Nils-Göran
authors.initials: NG
authors.lastname: Larsson
authors.affiliation: Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; Université de Bordeaux, Institut de Biochimie et Génétique Cellulaires UMR 5095, Saint-Saëns, F-33077 Bordeaux, France; CNRS, Institut de Biochimie et Génétique Cellulaires UMR 5095, Saint-Saëns, F-33077 Bordeaux, France. Electronic address: Arnaud.mourier@ibgc.cnrs.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Mourier
mesh_terms: D000818:Animals; D002461:Cell Line, Transformed; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D054629:Genome, Mitochondrial; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D008798:Mevalonic Acid / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics / Q000235:genetics*; D010085:Oxidative Phosphorylation; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism*
chemical_list: D005136:Eye Proteins; C506821:Gpr143 protein, mouse; D008562:Membrane Glycoproteins; D043562:Receptors, G-Protein-Coupled; D014451:Ubiquinone; D020558:GTP Phosphohydrolases; C488750:Mfn1 protein, mouse; C488751:Mfn2 protein, mouse; D008798:Mevalonic Acid
keywords: Bioenergetics; Coenzyme Q; Mevalonate pathway; Mitochondrial dynamics; Mitofusin 2