title: Use of autologous platelet-rich plasma in complete cleft palate repair.
abstract: Evaluate the effect of topical application of autologous platelet-rich plasma (PRP) in primary repair of complete cleft palate and then compare the result with another group of patients using the same surgical technique, without application of PRP with regard to the incidence of oronasal fistula, velopharyngeal closure, and grade of nasality.
  
  
  
  Case control study.
  
  
  
  This study was carried on 44 children with complete cleft palate with age range from 12 to 23 months. The children were divided into two age- and gender-matched groups: All children were subjected to the same technique of V-Y pushback repair of the complete cleft palate. In group A (22 children), the PRP prepared from the patient was topically applied between the nasal and oral mucosa layer during palatoplasty, whereas in group B (22 children) the PRP was not applied.
  
  
  
  All cases were recovered smoothly without problems. In group A, no oronasal fistula was reported, whereas in group B three patients (13.6%) had postoperative fistulae and two patients (9.1%) needed revision palatoplasty. At 6 months postoperative assessment, group A (with PRP application) showed significantly better grade of nasality (P = 0.024) and better endoscopic velopharyngeal closure (P = 0.016) than group B.
  
  
  
  Usage of autologous PRP in complete cleft palate repair is simple; effective; can decrease the incidence of oronasal fistula; and also significantly improves the grade of nasality and velopharyngeal closure, which decreases the need of further surgical intervention in cleft palate patients.
  
  
  
  3b. Laryngoscope, 126:1524-1528, 2016.
authors.affiliation: Otorhinolaryngology-Head and Neck Surgery Department , Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Mohammad Waheed
authors.initials: MW
authors.lastname: El-Anwar
authors.affiliation: Otorhinolaryngology-Head and Neck Surgery Department , Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Ahmed Abdel Fattah
authors.initials: AA
authors.lastname: Nofal
authors.affiliation: Surgery Department , Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Khalifa
authors.affiliation: Audiology Unit, Otorhinolaryngology-Head and Neck Surgery Department , Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Amal Saeed
authors.initials: AS
authors.lastname: Quriba
mesh_terms: D001804:Blood Transfusion, Autologous / Q000379:methods*; D016022:Case-Control Studies; D002972:Cleft Palate / Q000150:complications / Q000601:surgery*; D005260:Female; D005402:Fistula / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D009668:Nose Diseases / Q000453:epidemiology / Q000209:etiology; D016155:Oral Fistula / Q000453:epidemiology / Q000209:etiology; D010160:Palate, Soft / Q000601:surgery; D053657:Platelet-Rich Plasma; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D019651:Plastic Surgery Procedures / Q000379:methods*; D016896:Treatment Outcome; D014681:Velopharyngeal Insufficiency / Q000209:etiology / Q000601:surgery
keywords: Platelet-rich plasma; cleft palate; oronasal fistula; velopharyngeal incompetence