title: Humanin: Functional Interfaces with IGF-I.
abstract: Humanin is the first newly discovered peptide encoded in the mitochondrial genome in over three decades. It is the first member of a novel class of mitochondrial derived peptides. This small, 24 amino acid peptide was initially discovered to have neuroprotective effects and subsequent experiments have shown that it is beneficial in a diverse number of disease models including stroke, cardiovascular disease, and cancer. Over a decade ago, our lab found that humanin bound IGFBP-3 and more recent studies have found it to decrease circulating IGF-I levels. In turn, IGF-I also seems to regulate humanin levels and in this review, we cover the known interaction between humanin and IGF-I. Although the exact mechanism for how humanin and IGF-I regulate each other still needs to be elucidated, it is clear that humanin is a new player in IGF-I signaling.
authors.affiliation: Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: P
authors.initials: P
authors.lastname: Cohen
authors.affiliation: Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: kelvin.yen@usc.edu.
authors.forename: K
authors.initials: K
authors.lastname: Yen
mesh_terms: D000818:Animals; D054629:Genome, Mitochondrial / Q000235:genetics; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D047908:Intracellular Signaling Peptides and Proteins; C427211:humanin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: Growth hormone; Humanin; IGF-I; Mitochondria; Neuroprotection; Peptide