title: One-year interim comparison of canaloplasty in primary open-angle glaucoma following failed filtering surgery with primary canaloplasty.
abstract: OBJECTIVE
  This study was to explore the 1-year interim efficacy and safety of canaloplasty for primary open-angle glaucoma (POAG) with failed glaucoma filtration surgery (GFS) but an intact Schlemm's canal (SC).
  
  
  METHODS
  This was a single-surgeon prospective clinical study. Patients with POAG scheduled for canaloplasty were included and divided into two groups (with or without failed GFS). The status of SC was determined by gonioscopy and ultrasound biomicroscopy. Primary outcome measures included intraocular pressure (IOP) and glaucoma medication use at various follow-up points. The secondary outcome measure was the rate of surgical success.
  
  
  RESULTS
  Thirty-seven eyes were enrolled in group 1 (no GFS) and 23 eyes were enrolled in group 2 (failed GFS). The mean IOP (16.0±1.6 vs 16.2±1.6 mm Hg) and the number of medications (0.3±0.8 vs 0.3±0.6) at 18 months after canaloplasty were not significantly different between the two groups. There was no significant difference in complete success rate (criteria A: 52.2% vs 59.5%, p=0.587; criteria B: 39.1% vs 48.6%, p=0.343), as well as the qualified success rate (criteria A: 86.5% vs 82.6%, p=0.668; criteria B: 78.4% vs 69.6%, p=0.445). In group 2, the age, sex, number of previous surgeries, time span between operations were not significantly associated with surgery failure (p=0.199, 0.747, 0.977 and 0.615). Hyphaema was the most common postoperative complications.
  
  
  CONCLUSIONS
  Canaloplasty is an effective and safe option for POAG with failed GFS but an intact SC.
  
  
  BACKGROUND
  ChiCTR-ICR-15005788, Results.
authors.affiliation: Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.|Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xin
authors.affiliation: Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.|Department of Ophthalmology, Xuzhou 1st Hospital, Jiangsu, China.
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Huaizhou
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000601:surgery*; D005260:Female; D018463:Filtering Surgery / Q000009:adverse effects*; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D033401:Microscopy, Acoustic; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery*; D011446:Prospective Studies; D012086:Reoperation; D013997:Time Factors; D014792:Visual Acuity
keywords: Glaucoma; Treatment Surgery