title: Sensitivity of Dendritic Cells to Microenvironment Signals.
abstract: Dendritic cells are antigen-presenting cells capable of either activating the immune response or inducing and maintaining immune tolerance. They do this by integrating stimuli from the environment and changing their functional status as a result of plasticity. The modifications suffered by these cells have consequences in the way the organism may respond. In the present work two opposing situations known to affect dendritic cells are analyzed: tumor growth, leading to a microenvironment that favors the induction of a tolerogenic profile, and organ transplantation, which leads to a proinflammatory profile. Lessons learned from these situations may help to understand the mechanisms of modulation resulting not only from the above circumstances, but also from other pathologies.
authors.affiliation: Laboratório de Imunologia Tumoral, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Juliana Maria
authors.initials: JM
authors.lastname: Motta
authors.affiliation: Laboratório de Imunologia Tumoral, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Vivian Mary
authors.initials: VM
authors.lastname: Rumjanek
mesh_terms: D002454:Cell Differentiation; D016207:Cytokines / Q000235:genetics / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology*; D006084:Graft Rejection / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006085:Graft Survival; D006801:Humans; D007108:Immune Tolerance; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016377:Organ Transplantation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D058408:Th1-Th2 Balance; D059016:Tumor Microenvironment / Q000235:genetics / Q000276:immunology*
chemical_list: D016207:Cytokines