title: Keratoconjunctivitis sicca exacerbation in a dog treated with systemic atenolol.
abstract: A 6-year-old, intact, male English cocker spaniel was referred for treatment of chronic conjunctivitis and unilateral keratitis. The dog was diagnosed with bilateral immune-mediated keratoconjunctivitis sicca, treated with topical cyclosporine 0·2% ointment and sodium hyaluronate eye drops and improved considerably. After 2 months, pulmonic stenosis was diagnosed, and the dog commenced treatment with oral atenolol; the ophthalmological disease worsened dramatically within a few days. The ophthalmic signs rapidly improved after discontinuation of atenolol, and there was bilateral complete remission after 3 weeks. No oral β-blocker therapy was reintroduced, and thereafter, keratoconjunctivitis sicca was well-controlled with topical therapy.
authors.affiliation: Department of Veterinary Sciences, University of Pisa, Via Livornese (lato monte), 56122 San Piero a Grado, Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Barsotti
authors.affiliation: Department of Veterinary Sciences, University of Pisa, Via Livornese (lato monte), 56122 San Piero a Grado, Pisa, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Vezzosi
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000627:therapeutic use*; D000818:Animals; D001262:Atenolol / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy / Q000662:veterinary*; D008297:Male
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D001262:Atenolol