title: Proactive for invasion: Reuse of matrix metalloproteinase for structural memory.
abstract: Migratory cells translocate membrane type-1 matrix metalloproteinase (MT1-MMP) to podosomes or invadosomes to break extracellular matrix barriers. In this issue, El Azzouzi et al. (2016.J. Cell. Biol.http://dx.doi.org/10.1083/jcb.201510043) describe an unexpected function for the MT1-MMP cytoplasmic domain in imprinting spatial memory for podosome reformation via assembly in membrane islets.
authors.affiliation: Research Programs Unit, Genome-Scale Biology and Haartman Institute, University of Helsinki, Helsinki University Hospital and Finnish Cancer Institute, Helsinki FI-00014, Finland.
authors.forename: Erika
authors.initials: E
authors.lastname: Gucciardo
authors.affiliation: Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm SE-17165, Sweden.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mobashir
authors.affiliation: Research Programs Unit, Genome-Scale Biology and Haartman Institute, University of Helsinki, Helsinki University Hospital and Finnish Cancer Institute, Helsinki FI-00014, Finland Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm SE-17165, Sweden kaisa.lehti@ki.se.
authors.forename: Kaisa
authors.initials: K
authors.lastname: Lehti
mesh_terms: D002465:Cell Movement / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D000069261:Podosomes / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000502:physiology
chemical_list: D020782:Matrix Metalloproteinases; C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14