title: The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction?
abstract: The Crabtree and Warburg effects are two well-known deviations of cell energy metabolism that will be described herein. A number of hypotheses have been formulated regarding the molecular mechanisms leading to these cellular energy metabolism deviations. In this review, we will focus on the emerging notion that metabolite-induced regulations participate in the induction of these effects. All throughout this review, it should be kept in mind that no regulatory mechanism is exclusive and that it may vary in cancer cells owing to different cell types or oncogenic background. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.
authors.affiliation: Université Bordeaux, IBGC, UMR 5095, Bordeaux, France; Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Bordeaux, France.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Hammad
authors.affiliation: Université Bordeaux, IBGC, UMR 5095, Bordeaux, France; Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Bordeaux, France; Department of Molecular Genetics, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico DF, Mexico.
authors.forename: Monica
authors.initials: M
authors.lastname: Rosas-Lemus
authors.affiliation: Department of Molecular Genetics, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico DF, Mexico.
authors.forename: Salvador
authors.initials: S
authors.lastname: Uribe-Carvajal
authors.affiliation: Université Bordeaux, IBGC, UMR 5095, Bordeaux, France; Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Bordeaux, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Rigoulet
authors.affiliation: Université Bordeaux, IBGC, UMR 5095, Bordeaux, France; Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Bordeaux, France. Electronic address: anne.devin@ibgc.cnrs.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Devin
mesh_terms: D019069:Cell Respiration / Q000187:drug effects; D005635:Fructosediphosphates / Q000378:metabolism; D005636:Fructosephosphates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D019298:Glucose-6-Phosphate / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism* / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D005635:Fructosediphosphates; D005636:Fructosephosphates; D019298:Glucose-6-Phosphate; C027618:fructose-6-phosphate; D005947:Glucose; C029063:fructose-1,6-diphosphate; D010100:Oxygen
keywords: Crabtree; Glycolysis; Metabolites; Oxidative phosphorylation; Warburg