title: The Pretreatment Neutrophil/Lymphocyte Ratio Is Associated with All-Cause Mortality in Black and White Patients with Non-metastatic Breast Cancer.
abstract: The pretreatment neutrophil/lymphocyte ratio (NLR), derived from differential white blood cell counts, has been previously associated with poor prognosis in breast cancer. Little data exist, however, concerning this association in Black patients, who are known to have lower neutrophil counts than other racial groups. We conducted a retrospective cohort study of 236 Black and 225 non-Hispanic White breast cancer patients treated at a single institution. Neutrophil and lymphocyte counts were obtained from electronic medical records. Univariate and multivariate Cox regression models were used to determine hazard ratios (HRs) and 95% confidence intervals (95% CIs) of all-cause mortality and breast cancer-specific mortality in relation to pretreatment NLR. Overall, there were no associations between an elevated pretreatment NLR (NLR ≥3.7) and all-cause or breast cancer-specific mortality. Among patients without metastasis at the time of diagnosis, an elevated pretreatment NLR was independently associated with all-cause mortality, with a multivariable HR of 2.31 (95% CI: 1.10-4.86). Black patients had significantly lower NLR values than White patients, but there was no evidence suggesting racial heterogeneity of the prognostic utility of NLR. Pretreatment NLR was an independent predictor of all-cause mortality but not breast cancer-specific mortality in non-metastatic breast cancer patients.
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, Medical College of Georgia at Georgia Regents University , Augusta, GA , USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Rimando
authors.affiliation: Georgia Regents University Cancer Center , Augusta, GA , USA.
authors.forename: Jeff
authors.initials: J
authors.lastname: Campbell
authors.affiliation: Georgia Regents University Cancer Center , Augusta, GA , USA.
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, Medical College of Georgia at Georgia Regents University, Augusta, GA, USA; Georgia Regents University Cancer Center, Augusta, GA, USA.
authors.forename: Shou-Ching
authors.initials: SC
authors.lastname: Tang
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, Medical College of Georgia at Georgia Regents University, Augusta, GA, USA; Georgia Regents University Cancer Center, Augusta, GA, USA.
authors.forename: Sangmi
authors.initials: S
authors.lastname: Kim
keywords: Black patients; White patients; all-cause mortality; breast cancer; neutrophil/lymphocyte ratio