title: Enzyme- and Ruthenium-Catalyzed Enantioselective Transformation of α-Allenic Alcohols into 2,3-Dihydrofurans.
abstract: An efficient one-pot method for the enzyme- and ruthenium-catalyzed enantioselective transformation of α-allenic alcohols into 2,3-dihydrofurans has been developed. The method involves an enzymatic kinetic resolution and a subsequent ruthenium-catalyzed cycloisomerization, which provides 2,3-dihydrofurans with excellent enantioselectivity (up to >99 % ee). A ruthenium carbene species was proposed as a key intermediate in the cycloisomerization.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Can
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Youai
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden. jeb@organ.su.se.
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
keywords: allenic alcohols; asymmetric catalysis; cycloisomerization; kinetic resolution; ruthenium