title: Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients.
abstract: BACKGROUND
  The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behçet's disease patients with those of healthy controls.
  
  
  METHODS
  This case-control study compared a group of 30 patients with Behçet's disease with an age- and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented.
  
  
  RESULTS
  The nuclear and cytoplasmic areas of the BD patients' cells were significantly smaller than those of the healthy controls' cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae.
  
  
  CONCLUSIONS
  Behçet's disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques.
authors.affiliation: School of Medicine, Department of Family Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Aktunc
authors.affiliation: School of Medicine, Department of Medical Biology, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Zehra Safi
authors.initials: ZS
authors.lastname: Oz
authors.affiliation: Department of Pathology, Taksim Education and Research Hospital, 34433 Istanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Bektas
authors.affiliation: School of Medicine, Department of Dermatology, Selçuk University, 42075 Konya, Turkey.
authors.forename: Cevdet
authors.initials: C
authors.lastname: Altinyazar
authors.affiliation: School of Medicine, Department of Dermatology, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Rafet
authors.initials: R
authors.lastname: Koca
authors.affiliation: School of Medicine, Department of Dermatology, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Bostan
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000175:diagnosis / Q000473:pathology*; D016022:Case-Control Studies; D002467:Cell Nucleus / Q000473:pathology; D048429:Cell Size; D016009:Chi-Square Distribution; D003581:Cytodiagnosis / Q000379:methods; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D020556:Neutrophil Infiltration; D010338:Pathology, Clinical / Q000379:methods*; D055815:Young Adult