title: Controlled actuation of therapeutic nanoparticles: an update on recent progress.
abstract: A primary envisioned use for nanoparticles (NPs) in a cellular context is for controlled drug delivery where the full benefit of NP attributes (small size, large drug cargo loading capacity) can improve the pharmacokinetics of the drug cargo. This requires the ability to controllably manipulate the release of the drug cargo from the NP vehicle or 'controlled actuation'. In this review, we highlight new developments in this field from 2013 to 2015. The number and breadth of reports are a testament to the significant advancements made in this field over this time period. We conclude with a perspective of how we envision this field to continue to develop in the years to come.
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
authors.forename: Okhil K
authors.initials: OK
authors.lastname: Nag
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
authors.forename: Lauren D
authors.initials: LD
authors.lastname: Field
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
authors.forename: YungChia
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
authors.forename: Ajmeeta
authors.initials: A
authors.lastname: Sangtani
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
authors.forename: Joyce C
authors.initials: JC
authors.lastname: Breger
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: Delehanty
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage*; D011817:Rabbits; D051381:Rats
keywords: actuation; nanoparticle; therapeutic