title: [Acute Hyperuricemia and Kidney Injury after Three Cycles of Dose-Dense Chemotherapy for Retroperitoneal Choriocarcinoma -- A Case Report].
abstract: A 32 year-old man was diagnosed with retroperitoneal choriocarcinoma with metastasis to the lungs and liver. One cycle of modified BEP regimen did not sufficiently decrease the hCG. Therefore, we chose the GETUG 13 protocol of dose dense chemotherapy. After 6 days of cisplatin administration(3 cycles), he was diagnosed with acute hyperuricemia and kidney injury. He was treated with intravenous hydration and rasburicase. The hyperuricemia improved after a few days.
authors.affiliation: Dept. of Medical Oncology, Nippon Medical School Musashikosugi Hospital.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Sakai
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsuda
authors.forename: Genmu
authors.initials: G
authors.lastname: Kadokura
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Katsumata
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D033461:Hyperuricemia / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014503:Urate Oxidase / Q000627:therapeutic use
chemical_list: C469709:rasburicase; D005047:Etoposide; D014503:Urate Oxidase; D002945:Cisplatin