title: Factors affecting survival in acute leukemia with donor lymphocyte infusion in the first relapse after allogeneic stem cell transplantation.
abstract: OBJECTIVE
  Relapse of leukemia relapsing after allogeneic (allo) stem cell transplantation (SCT) remains an important problem. Cytoreductive chemotherapy followed by donor leukocyte infusion (DLI) is one of the treatment modalities in relapsed patients. The current study evaluated the factors affecting overall survival (OS) in allo-SCT patients who received DLI after the first relapse.
  
  
  METHODS
  In this retrospective study 54 patients (26 with acute myeloid leukemia [AML] and 28 with acute lymphoblastic leukemia [ALL]) in their first relapse after allo-SCT who received fludarabine-based chemotherapy followed by DLI were evaluated.
  
  
  RESULTS
  The relative risk for mortality was significantly higher in patients with acute leukemia (AL) within the high-risk group who went through transplantation (risk ratio: 4.866; 95% CI: 2.029-11.670;p<0.001) and in transplants performed in the remission phases following the first complete remission (risk ratio: 2.371; 95% CI: 1.154 - 4.872; p=0.019). Additionally, the relative mortality risk of transplantation in patients with acute leukemia (AL) with a number of DLIs applied (risk ratio: 0.456; 95% CI: 0.29 - 0.717; p=0.001) nd non-myeloablative regimen (risk ratio: 0.229; 95% CI: 0.053-0.992; p=0.049) was significantly lower.
  
  
  CONCLUSIONS
  Efforts to enhance the number of DLIs, thus the number of infused cells, may result in better OS in cases with AL with relapse.
authors.affiliation: Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri,Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kurnaz
authors.forename: Cem
authors.initials: C
authors.lastname: Sahin
authors.forename: Leylagul
authors.initials: L
authors.lastname: Kaynar
authors.forename: Cigdem
authors.initials: C
authors.lastname: Pala
authors.forename: Serdar
authors.initials: S
authors.lastname: Sivgin
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntas
authors.forename: Bulent
authors.initials: B
authors.lastname: Eser
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.forename: Ali
authors.initials: A
authors.lastname: Unal
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000628:therapy*; D017710:Lymphocyte Transfusion; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000628:therapy*; D012008:Recurrence; D012189:Retrospective Studies; D014019:Tissue Donors; D014184:Transplantation, Homologous