title: hOGG1gene polymorphisms and susceptibility to polycystic ovary syndrome.
abstract: Oxidative stress generates 8-hydroxy-2'-deoxyguanine (8-oxodG), which can structurally modify DNA. Glycosylase hOGG1 can remove the mutagenic lesion 8-oxodG from DNA. The aim of the present study was to determine whether polymorphisms in hOGG1 were associated with the risk of polycystic ovary syndrome (PCOS). One common single-nucleotide polymorphism (Ser326Cys) in exon 7 and four rare polymorphisms (c.-18G>T, c.-23A>G, c.-45G>A and c. -53G>C) were screened in the 5' untranslated region of thehOGG1gene. No such distributional differences were observed between the PCOS patients and controls either in the genotype frequency or in the allele frequency. There were no differences in the clinical variables among the different genotypes in all the variants, except that the follicle-stimulating hormone level was elevated in the GC genotype of c. -53G>C in PCOS patients (P=0.002). These results suggest that the polymorphisms inhOGG1may not be an independent risk factor for PCOS.
authors.affiliation: Center of Prenatal Diagnosis, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China; Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Wang
authors.affiliation: Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.
authors.forename: Shanmei
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Obstetrics and Gynecology, Anhui Medical University, Hefei, Anhui 230022, P.R. China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Yi
authors.affiliation: Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
keywords: 5′ untranslated region; genetic polymorphism; hOGG1; polycystic ovary syndrome