title: The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold.
abstract: Nuclear proteins are often given a concise title that captures their function, such as 'transcription factor,' 'polymerase' or 'nuclear-receptor.' However, for members of the Drosophila behavior/human splicing (DBHS) protein family, no such clean-cut title exists. DBHS proteins are frequently identified engaging in almost every step of gene regulation, including but not limited to, transcriptional regulation, RNA processing and transport, and DNA repair. Herein, we present a coherent picture of DBHS proteins, integrating recent structural insights on dimerization, nucleic acid binding modalities and oligomerization propensity with biological function. The emerging paradigm describes a family of dynamic proteins mediating a wide range of protein-protein and protein-nucleic acid interactions, on the whole acting as a multipurpose molecular scaffold. Overall, significant steps toward appreciating the role of DBHS proteins have been made, but we are only beginning to understand the complexity and broader importance of this family in cellular biology.
authors.affiliation: School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, WA 6009, Australia.
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: Knott
authors.affiliation: School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, WA 6009, Australia.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Bond
authors.affiliation: School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Western Australia, WA 6009, Australia Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA 6009, Australia archa.fox@uwa.edu.au.
authors.forename: Archa H
authors.initials: AH
authors.lastname: Fox
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins; D004331:Drosophila melanogaster; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism* / Q000648:ultrastructure; D009687:Nuclear Proteins / Q000378:metabolism* / Q000648:ultrastructure; D050810:Octamer Transcription Factors / Q000378:metabolism* / Q000648:ultrastructure; D000072670:PTB-Associated Splicing Factor / Q000378:metabolism* / Q000648:ultrastructure; D060066:Protein Interaction Maps; D017433:Protein Structure, Secondary; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D000072260:RNA Splicing Factors / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism* / Q000648:ultrastructure; D014158:Transcription, Genetic / Q000235:genetics; D015533:Transcriptional Activation / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C083214:NONO protein, human; D034521:Nuclear Matrix-Associated Proteins; D009687:Nuclear Proteins; D050810:Octamer Transcription Factors; C450059:PSPC1 protein, human; D000072670:PTB-Associated Splicing Factor; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins