title: Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer.
abstract: We have developed nanomedicine vehicle based on a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. The synthesized ABA type copolymer had a low polydispersity index and formed small, highly stable spherical micelles. Furthermore, a functional group at the end site of the copolymer can be decorated with imaging agents and targeting moieties. The doxorubicin loaded micelles (DLM) showed higher drug-loading capacity, faster drug release, and better cell toxicity compared to those using di-block copolymers. DLM efficiently delivered to the metastatic breast cancers in brain and bone and suppressed growing of metastasis. In demonstration of treating metastasized animal model, we present a tri-block copolymer as a potential nanomedicine vehicle to efficiently deliver anticancer drug and to effectively treat metastatic breast cancer.
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 120-752, Republic of Korea.
authors.forename: Ho-Taek
authors.initials: HT
authors.lastname: Song
authors.affiliation: College of Pharmacy, Chung-Ang University, 221 Heukseok Dong, Dongjak-Gu, Seoul 155-756, Republic of Korea.
authors.forename: Ngoc Ha
authors.initials: NH
authors.lastname: Hoang
authors.affiliation: College of Pharmacy, Chung-Ang University, 221 Heukseok Dong, Dongjak-Gu, Seoul 155-756, Republic of Korea.
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Yun
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 120-752, Republic of Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Park
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 120-752, Republic of Korea.
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Song
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-Dong, Wonmi-Gu, Bucheon, Gyeonggi-Do 420-743, Republic of Korea.
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
authors.affiliation: School of Pharmacy, SungKyunKwan University, 300 Cheoncheon-Dong, Jangan-Gu, Suwon City 440-746, Republic of Korea.
authors.forename: Yu Seok
authors.initials: YS
authors.lastname: Youn
authors.affiliation: College of Pharmacy, Chung-Ang University, 221 Heukseok Dong, Dongjak-Gu, Seoul 155-756, Republic of Korea. Electronic address: kyungoh@cau.ac.kr.
authors.forename: Kyung Taek
authors.initials: KT
authors.lastname: Oh
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008823:Micelles; D009362:Neoplasm Metastasis; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D008823:Micelles; D011091:Polyesters; C499774:polyethylene glycol-polylactide-polyethylene glycol; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: Animal imaging; Biocompatibility; Metastasis; Nanomedicine; Tri-block copolymer