title: MetaMHCpan, A Meta Approach for Pan-Specific MHC Peptide Binding Prediction.
abstract: Recent computational approaches in bioinformatics can achieve high performance, by which they can be a powerful support for performing real biological experiments, making biologists pay more attention to bioinformatics than before. In immunology, predicting peptides which can bind to MHC alleles is an important task, being tackled by many computational approaches. However, this situation causes a serious problem for immunologists to select the appropriate method to be used in bioinformatics. To overcome this problem, we develop an ensemble prediction-based Web server, which we call MetaMHCpan, consisting of two parts: MetaMHCIpan and MetaMHCIIpan, for predicting peptides which can bind MHC-I and MHC-II, respectively. MetaMHCIpan and MetaMHCIIpan use two (MHC2SKpan and LApan) and four (TEPITOPEpan, MHC2SKpan, LApan, and MHC2MIL) existing predictors, respectively. MetaMHCpan is available at http://datamining-iip.fudan.edu.cn/MetaMHCpan/index.php/pages/view/info .
authors.affiliation: School of Computer Science, Fudan University, 220 Handan Road, Shanghai, 200433, China.|Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, 200433, China.
authors.forename: Yichang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: School of Computer Science, Fudan University, 220 Handan Road, Shanghai, 200433, China.|Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, 200433, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.affiliation: Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, 611-0011, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mamitsuka
authors.affiliation: School of Computer Science, Fudan University, 220 Handan Road, Shanghai, 200433, China. zhusf@fudan.edu.cn.|Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, 200433, China. zhusf@fudan.edu.cn.
authors.forename: Shanfeng
authors.initials: S
authors.lastname: Zhu
mesh_terms: D019295:Computational Biology / Q000379:methods*; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D020407:Internet; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding; D012984:Software
chemical_list: D006680:HLA Antigens; D010455:Peptides
keywords: Binding peptides; MHC-I; MHC-II; MHC2MIL; MHC2SKpan; MetaMHCpan; TEPITOPEpan