title: Expression of Podoplanin in Non-melanoma Skin Cancers and Actinic Keratosis.
abstract: OBJECTIVE
  Recent studies have indicated that expression of podoplanin changes during the neoplastic processes, we therefore aimed at assessing its expression in cancer and stromal cells of basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and actinic keratosis (AK).
  
  
  METHODS
  Formalin-fixed paraffin-embedded tissue samples of 134 patients (38 BCC, 57 SCC, 20 AK and from 19 healthy volunteers) were analyzed. Podoplanin-immunoreactivity was detected in 32.1%/44.7%, 70%/20% and 87.7%/79% for BCC, AK and SCC tumour/stroma cells, respectively. Mean podoplanin expression in tumour cells was 1.2±1.8, 1.4±1.1 and 5.6±3.9 for BCC, AK and SCC, respectively. Mean podoplanin expression in stromal cells was 1.5±2.3, 0.65±1.57 and 3.2±2.4 for BCC, AK and SCC, respectively. Podoplanin expression was significantly higher in SCC stromal cells compared to the rest of the analyzed groups (p<0.001), suggesting a potential role of podoplanin in the development and progression of this malignancy.
authors.affiliation: Department of Dermatology, Venerology and Allergology, Medical University, Wroclaw, Poland martazdrojowy@wp.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Wojciechowska-Zdrojowy
authors.affiliation: Department of Dermatology, Venerology and Allergology, Medical University, Wroclaw, Poland.
authors.forename: Jacek C
authors.initials: JC
authors.lastname: Szepietowski
authors.affiliation: Department of Dermatology, Venerology and Allergology, Medical University, Wroclaw, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Matusiak
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland Department of Physiotherapy, University School of Physical Education, Wroclaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Dzięgiel
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Puła
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D055623:Keratosis, Actinic / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism*; D055815:Young Adult; D000098853:Podoplanin
chemical_list: D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin
keywords: Podoplanin; actinic keratosis; basal cell carcinoma; skin cancer; skin cancerogenesis; squamous cell carcinoma