title: Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts.
abstract: Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether Q10 could effectively prevent cardio-toxicity caused by doxorubicin treatment. Four week old SD rats were segregated into groups namely control, doxorubicin group (challenged with doxorubicin), Dox + Q10 group (with doxorubicin challenge and oral Q10 treatment), and Q10 group (with oral Q10 treatment). Doxorubicin groups received IP doxorubicin (2.5 mg/kg) every 3 days and Q10 groups received Q10 (10 mg/kg) every day. Three weeks of doxorubicin challenge caused significant reduction in heart weight, disarray in cardiomyocyte arrangement, elevation of collagen accumulation, enhancement of fibrosis and cell death associated proteins, and inhibition of survival proteins. However, Q10 effectively protected cardiomyocytes and ameliorated fibrosis and cell death induced by doxorubicin. Q10 is, therefore, evidently a potential drug to prevent heart damage caused by doxorubicin. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 679-689, 2017.
authors.affiliation: Department of Pathology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Chen
authors.affiliation: Department of Sports Sciences, University of Taipei, Taipei, Taiwan.
authors.forename: Chien-Wen
authors.initials: CW
authors.lastname: Hou
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Marthandam Asokan
authors.initials: MA
authors.lastname: Shibu
authors.affiliation: Department of Nursing, MeiHo University, Pingtung, Taiwan.
authors.forename: Cecilia Hsuan
authors.initials: CH
authors.lastname: Day
authors.affiliation: Division of Cardiology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Peiying
authors.initials: P
authors.lastname: Pai
authors.affiliation: Department of Biotechnology, Asia University, Taichung, Taiwan.
authors.forename: Zhao-Rong
authors.initials: ZR
authors.lastname: Liu
authors.affiliation: Department of Pathology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Tze-Yi
authors.initials: TY
authors.lastname: Lin
authors.affiliation: Department of Biotechnology, Bharathiar University, Coimbatore, 641 046, India.
authors.forename: Vijaya Padma
authors.initials: VP
authors.lastname: Viswanadha
authors.affiliation: Department of Sports Sciences, University of Taipei, Taipei, Taiwan.
authors.forename: Chia-Hua
authors.initials: CH
authors.lastname: Kuo
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.|Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.|Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D009202:Cardiomyopathies / Q000139:chemically induced / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000009:adverse effects*; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D002316:Cardiotonic Agents; D014451:Ubiquinone; D004317:Doxorubicin; C024989:coenzyme Q10
keywords: cardiac apoptosis; cardiac fibrosis; cardio-toxicity; coenzyme Q10