title: Bovine serum albumin-cobalt(ii) Schiff base complex hybrid: an efficient artificial metalloenzyme for enantioselective sulfoxidation using hydrogen peroxide.
abstract: An artificial metalloenzyme (BSA-CoL) based on the incorporation of a cobalt(ii) Schiff base complex {CoL, H2L = 2,2'-[(1,2-ethanediyl)bis(nitrilopropylidyne)]bisphenol} with bovine serum albumin (BSA) has been synthesized and characterized. Attention is focused on the catalytic activity of this artificial metalloenzyme for enantioselective oxidation of a variety of sulfides with H2O2. The influences of parameters such as pH, temperature, and the concentration of catalyst and oxidant on thioanisole as a model are investigated. Under optimum conditions, BSA-CoL as a hybrid biocatalyst is efficient for the enantioselective oxidation of a series of sulfides, producing the corresponding sulfoxides with excellent conversion (up to 100%), chemoselectivity (up to 100%) and good enantiomeric purity (up to 87% ee) in certain cases.
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (School of Chemistry and Pharmacy, Guangxi Normal University), Guilin, 541004, P. R. China. huangfp2010@163.com and Guilin Normal College, Guilin 541001, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (School of Chemistry and Pharmacy, Guangxi Normal University), Guilin, 541004, P. R. China. huangfp2010@163.com.
authors.forename: Fuping
authors.initials: F
authors.lastname: Huang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (School of Chemistry and Pharmacy, Guangxi Normal University), Guilin, 541004, P. R. China. huangfp2010@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wei
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (School of Chemistry and Pharmacy, Guangxi Normal University), Guilin, 541004, P. R. China. huangfp2010@163.com and School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Key Laboratory of Chemistry and Engineering of Forest Products, Nanning, 530008, P. R. China. gxunchem@163.com.
authors.forename: Hedong
authors.initials: H
authors.lastname: Bian
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (School of Chemistry and Pharmacy, Guangxi Normal University), Guilin, 541004, P. R. China. huangfp2010@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (School of Chemistry and Pharmacy, Guangxi Normal University), Guilin, 541004, P. R. China. huangfp2010@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D006861:Hydrogen Peroxide; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012545:Schiff Bases / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D012545:Schiff Bases; D012710:Serum Albumin, Bovine; D003035:Cobalt; D006861:Hydrogen Peroxide