title: DNA Binding Behavior, Sensor Studies, Antimicrobial, Photocleavage and In vitro Cytotoxicity of Synthesized Ru(II) Complexes with Assorted Intercalating Polypyridyl Ligands.
abstract: The four novel Ru(II) polypyridyl complexes of [Ru(Hdpa)2dmbip](2+) (1), [Ru(Hdpa)2NO2-dmbip](2+) (2), [Ru(Hdpa)2debip](2+) (3) and [Ru(Hdpa)2OH-debip](2+) (4) where Hdpa = 2,2'-bipyridylamine, dmbip = 2-(4-N,N-dimethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, debip = 2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, NO2-dmbip = NO2-2-(4-N,N-dimethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, OH-debip = OH-2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline were synthesized and fully characterized using elemental analysis, Mass, NMR and FT-IR. The DNA binding behavior of all synthesized complexes were investigated by using electronic absorption spectra, emission spectra, cyclic light switch on and off, sensor studies, electrochemical method and viscosity titrations. Docking studies were performed with human DNA TOP1 by using LibDock. Furthermore explore antimicrobial activity, photocleavage and in vitro cytotoxicity assay of four Ru(II) complexes.
authors.affiliation: Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana State, 500007, India.
authors.forename: Rajender Reddy
authors.initials: RR
authors.lastname: Mallepally
authors.affiliation: Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana State, 500007, India.
authors.forename: Venkat Reddy
authors.initials: VR
authors.lastname: Putta
authors.affiliation: Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana State, 500007, India.
authors.forename: Nagamani
authors.initials: N
authors.lastname: Chintakuntla
authors.affiliation: Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana State, 500007, India.
authors.forename: Ravi Kumar
authors.initials: RK
authors.lastname: Vuradi
authors.affiliation: Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana State, 500007, India.
authors.forename: Laxma Reddy
authors.initials: LR
authors.lastname: Kotha
authors.affiliation: Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana State, 500007, India. ssnsirasani@gmail.com.
authors.forename: Satyanarayana
authors.initials: S
authors.lastname: Sirasani
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects*; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D062105:Molecular Docking Simulation; D010618:Phenanthrolines / Q000737:chemistry; D055668:Photochemical Processes; D011487:Protein Conformation; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D007364:Intercalating Agents; D008024:Ligands; D010618:Phenanthrolines; D011725:Pyridines; D012428:Ruthenium; D004247:DNA; D004264:DNA Topoisomerases, Type I; C023666:pyridine
keywords: Antimicrobial activity; DNA binding; In vitro cytotoxicity; Photocleavage; Ru(II) polypyridyl complexes