title: GIPC: Glycosyl Inositol Phospho Ceramides, the major sphingolipids on earth.
abstract: What are the most abundant sphingolipids on earth? The answer is Glycosyl Inositol Phosphoryl Ceramides (GIPCs) present in fungi and the green lineage. In this review, we discuss the putative role of plant GIPCs in the lipid bilayer asymmetry, in the lateral organization of membrane rafts and in the very long chain fatty acid inter-leaflet coupling of lipids in the plant plasma membrane (PM). A special focus on the structural similarities -and putative functions- of GIPCs is discussed by comparison with animal gangliosides, structural homologs of plant GIPCs.
authors.affiliation: a Laboratoire de Biogenèse Membranaire (LBM), CNRS-University of Bordeaux , Villenave d'Ornon Cedex , France.
authors.forename: Julien
authors.initials: J
authors.lastname: Gronnier
authors.affiliation: a Laboratoire de Biogenèse Membranaire (LBM), CNRS-University of Bordeaux , Villenave d'Ornon Cedex , France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Germain
authors.affiliation: a Laboratoire de Biogenèse Membranaire (LBM), CNRS-University of Bordeaux , Villenave d'Ornon Cedex , France.
authors.forename: Paul
authors.initials: P
authors.lastname: Gouguet
authors.affiliation: a Laboratoire de Biogenèse Membranaire (LBM), CNRS-University of Bordeaux , Villenave d'Ornon Cedex , France.|b Université de Bourgogne , Dijon Cedex , France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Cacas
authors.affiliation: a Laboratoire de Biogenèse Membranaire (LBM), CNRS-University of Bordeaux , Villenave d'Ornon Cedex , France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Mongrand
mesh_terms: D000818:Animals; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D021962:Membrane Microdomains / Q000378:metabolism; D008954:Models, Biological; D010944:Plants / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism*
chemical_list: D002518:Ceramides; D013107:Sphingolipids
keywords: Cell wall; GIPC; Plasma membrane; Sphingolipids; Sterols; VLFCA; gangliosides; interdigitation continuum; plant defense; raft domain