title: In vivo anticancer activity of maesopsin 4-O-β-glucoside isolated from leaves of Artocarpus tonkinensis A. Chev. Ex Gagnep.
abstract: OBJECTIVE
  To investigate the antitumor effect of maesopsin 4-O-β-glucoside (TAT2) isolated from the leaves of Artocarpus tonkinensis (A. tonkinensis) A. Chev. ex Gagnep.
  
  
  METHODS
  The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma (LLC) tumor-bearing mice. BALB/c mice had tumors induced by implantation with 2 × 10(6) LLC cells into the subcutaneous right posterior flank. Tumor-bearing mice were treated orally with a range of doses of TAT2 and a standard drug, doxorubicin. Animals were observed for tumor growth and mortality rate. Blood was collected to determine hematological and biochemical parameters.
  
  
  RESULTS
  TAT2 was isolated from an ethanolic extract of A. tonkinensis leaves. Its structure was determined by MS and NMR spectroscopy, and identified as TAT2. The compound did not show acute toxicity at the highest dose tested (2000 mg/kg body weight). TAT2 exhibited antitumor activity by decreasing tumor growth, increasing the survival rate, and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight (P < 0.05).
  
  
  CONCLUSIONS
  These results indicate that TAT2 possesses clear antitumor activity. Due to its bioavailability and low toxicity, and the fact that it could be isolated in a large scale from A. tonkinensis leaves, the compound shows promise as a potential anticancer drug.
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam. Electronic address: drthuy2001@yahoo.de.
authors.forename: Trinh Thi
authors.initials: TT
authors.lastname: Thuy
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam.
authors.forename: Dao Duc
authors.initials: DD
authors.lastname: Thien
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam.
authors.forename: Tran
authors.initials: T
authors.lastname: Quang Hung
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam.
authors.forename: Nguyen Thanh
authors.initials: NT
authors.lastname: Tam
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam.
authors.forename: Nguyen Thi Hoang
authors.initials: NTH
authors.lastname: Anh
authors.affiliation: Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam.
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Nga
authors.affiliation: Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam.
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Cuc
authors.affiliation: National Research Council Canada, Measurement Science and Standards, 1200 Montreal Road, Building M-12, Ottawa, Ontario K1A 0R6, Canada.
authors.forename: Le Phuong
authors.initials: LP
authors.lastname: Mai
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam.
authors.forename: Tran
authors.initials: T
authors.lastname: Van Sung
authors.affiliation: Department of Medicine, University of Perugia, Piazzale Gambuli, S.Andrea delle Fratte, 06132 Perugia, Italy.
authors.forename: Domenico V
authors.initials: DV
authors.lastname: Delfino
authors.affiliation: Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam. Electronic address: thaodo@ibt.ac.vn.
authors.forename: Do Thi
authors.initials: DT
authors.lastname: Thao
keywords: Artocarpus tonkinensis; BALB/c; Hematological parameters; Lewis lung carcinoma; Maesopsin 4-O-β-glucoside