title: The modified CKD-EPI equation may be not more accurate than CKD-EPI equation in determining glomerular filtration rate in Chinese patients with chronic kidney disease.
abstract: OBJECTIVE
  To investigate the application of the new modified Chronic Kidney Disease Epidemiology Collaboration (mCKD-EPI) equation developed by Liu for the measurement of glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD) and to evaluate whether this modified form is more accurate than the original one in clinical practice.
  
  
  METHODS
  GFR was determined simultaneously by 3 methods: (a)99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) dual plasma sample clearance method (mGFR), which was used as the reference standard; (b) CKD-EPI equation (eGFRckdepi); (c) modified CKD-EPI equation (eGFRmodified). Concordance correlation and Passing-Bablok regression were used to compare the validity of eGFRckdepi and eGFRmodified. Bias, precision and accuracy were compared to identify which equation showed the better performance in determining GFR.
  
  
  RESULTS
  A total of 170 patients were enrolled. Both eGFRckdepi and eGFRmodified correlated well with mGFR (concordance correlation coefficient 0.90 and 0.74, respectively) and the Passing-Bablok regression equation of eGFRckdepi and eGFRmodified against mGFR was mGFR = 0.37 + 1.04 eGFRckdepi and -49.25 + 1.74 eGFRmodified, respectively. In terms of bias, precision and 30 % accuracy, eGFRmodified showed a worse performance compared to eGFRckdepi, in the whole cohort.
  
  
  CONCLUSIONS
  The new modified CKD-EPI equation cannot replace the original CKD-EPI equation in determining GFR in Chinese patients with CKD.
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People's Republic of China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Huang
authors.affiliation: Institute of Nephrology, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Radiology, the Second Hospital, Hebei Medical University, No.215 Heping Road, Xinhua District, Shijiazhuang, Hebei, 050005, People's Republic of China. woxinfly1982@126.com.
authors.forename: Huai-Jun
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Department of Research, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D015203:Reproducibility of Results; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage
chemical_list: D015415:Biomarkers; D019275:Radiopharmaceuticals; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate
keywords: CKD-EPI equation; Chronic kidney disease; Glomerular filtration rate; Modified CKD-EPI equation