title: Comparison of Allograft and Autograft in Lumbar Fusion for Lumbar Degenerative Diseases: A Systematic Review.
abstract: Purpose/Aim of the study: The purpose of this analysis was to compare the clinical outcomes of vertebral fusion with allograft versus autograft bone.
  
  
  METHODS
  Medline, PubMed, Cochrane, EMBASE, and Google Scholar databases were searched until July 27, 2015 using the keywords: lumbar vertebrae, surgery, spondylolisthesis, bone transplantation, allograft, autograft. Inclusion criteria were randomized controlled trials (RCTs), two-arm prospective studies, retrospective studies, and cohort studies comparing the results of autograft and allograft in patients receiving lumbar spinal fusion. The outcomes were changes of Oswestry Disability Index (ODI) and visual analogue scale (VAS) pain scores from baseline at 1, 2, and 3 years after surgery and fusion rates.
  
  
  RESULTS
  Of 154 studies identified in the database searches, five were included in the quantitative analysis (one RCT, one prospective, and three retrospective studies). The mean patient age ranged from approximately 40 to 65 years, and approximately half of the patients were males. The total number of patients who received allografts was 333 and the total that received autografts was 175. The analysis revealed the change of ODI and VAS pain score at 1, 2 and 3 years was similar between the allograft and autograft groups (all, p > .05), as were the fusion rates (p > .05).
  
  
  CONCLUSIONS
  Both allograft and autograft provide acceptable outcomes for spinal fusion.
authors.affiliation: a Department of Spine Surgery, Second Affiliated Fuzhou Hospital of Xiamen University, The Second Teaching Hospital of Fuzhou City, Fujian Medical University , Fuzhou , Fujian , China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Liao
authors.affiliation: a Department of Spine Surgery, Second Affiliated Fuzhou Hospital of Xiamen University, The Second Teaching Hospital of Fuzhou City, Fujian Medical University , Fuzhou , Fujian , China.
authors.forename: Chao-Hui
authors.initials: CH
authors.lastname: Wang
authors.affiliation: a Department of Spine Surgery, Second Affiliated Fuzhou Hospital of Xiamen University, The Second Teaching Hospital of Fuzhou City, Fujian Medical University , Fuzhou , Fujian , China.
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Cui
mesh_terms: D064591:Allografts; D064592:Autografts; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D008159:Lumbar Vertebrae / Q000601:surgery*; D010147:Pain Measurement; D013123:Spinal Fusion / Q000379:methods*; D016896:Treatment Outcome
keywords: allograft; autograft; degenerative disc disease; lumbar fusion; meta-analysis; systematic review