title: BPC 157: The counteraction of succinylcholine, hyperkalemia, and arrhythmias.
abstract: After the demonstration of its life-saving effect in severe hyperkalemia and the recovery of skeletal muscle after injury, pentadecapeptide BPC 157 has been shown to attenuate the local paralytic effect induced by succinylcholine, in addition to systemic muscle disability (and consequent muscle damage). Hyperkalemia, arrhythmias and a rise in serum enzyme values, were counteracted in rats. Assessments were made at 3 and 30min and 1, 3, 5, and 7 days after succinylcholine administration (1.0mg/kg into the right anterior tibial muscle). BPC 157 (10µg/kg, 10ng/kg) (given intraperitoneally 30min before or immediately after succinylcholine or per-orally in drinking water through 24h until succinylcholine administration) mitigated both local and systemic disturbances. BPC 157 completely eliminated hyperkalemia and arrhythmias, markedly attenuated or erradicated behavioral agitation, muscle twitches, motionless resting and completely eliminated post-succinylcholine hyperalgesia. BPC 157 immediately eliminated leg contractures and counteracted both edema and the decrease in muscle fibers in the diaphragm and injected/non-injected anterior tibial muscles. Therefore, the depolarizing neuromuscular blocker effects of succinylcholine were successfully antagonized.
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Vasilije
authors.initials: V
authors.lastname: Stambolija
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Tamara Perleta
authors.initials: TP
authors.lastname: Stambolija
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Jadranka Katancic
authors.initials: JK
authors.lastname: Holjevac
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Murselovic
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Radonic
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Viktor
authors.initials: V
authors.lastname: Duzel
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Bozidar
authors.initials: B
authors.lastname: Duplancic
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Uzun
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Zivanovic-Posilovic
authors.affiliation: Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Kolenc
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Domagoj
authors.initials: D
authors.lastname: Drmic
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Romic
authors.affiliation: Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.affiliation: Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia. Electronic address: sikiric@mef.hr.
authors.forename: Predrag
authors.initials: P
authors.lastname: Sikiric
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006947:Hyperkalemia / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D046353:Immobility Response, Tonic / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000473:pathology; D010243:Paralysis / Q000150:complications; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D011595:Psychomotor Agitation / Q000150:complications; D051381:Rats; D017208:Rats, Wistar; D013390:Succinylcholine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
chemical_list: D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157; D013390:Succinylcholine
keywords: Arrhythmias; BPC 157; Hyperkalemia; Rats; Succinylcholine