title: Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis.
abstract: Previous studies have reported aberrant expression of the miR-183-96-182 cluster in a variety of tumors, which indicates its' diagnostic or prognostic value. However, a key characteristic of the miR-183-96-182 cluster is its varied expression levels, and pleomorphic functional roles in different tumors or under different conditions. In most tumor types, the cluster is highly expressed and promotes tumorigenesis, cancer progression and metastasis; yet tumor suppressive effects have also been reported in some tumors. In the present study, we discuss the upstream regulators and the downstream target genes of miR-183-96-182 cluster, and highlight the dysregulation and functional roles of this cluster in various tumor cells. Newer insights summarized in this review will help readers understand the different facets of the miR-183-96-182 cluster in cancer development and progression.
authors.affiliation: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
authors.forename: A-Juan
authors.initials: AJ
authors.lastname: Liang
authors.affiliation: Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Fan
authors.affiliation: Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Yi-Ran
authors.initials: YR
authors.lastname: Huang
authors.affiliation: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.|Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiang-Feng
authors.initials: XF
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D011379:Prognosis; D034622:RNA Interference
chemical_list: C533449:MIRN183 microRNA, human; C541492:MIRN96 microRNA, human; D035683:MicroRNAs; C538984:Mirn182 microRNA, human
keywords: cancer development; cancer progression; metastasis; miR-183-96-182 cluster; prognosis