title: Oxygen Monitoring Reduces the Risk for Retinopathy of Prematurity in a Mexican Population.
abstract: Retinopathy of prematurity (ROP), a potentially blinding disease, affects preterm infants. High levels of oxygen saturation are a well-known risk factor for ROP.
  
  
  
  To assess the frequency of ROP type 1 needing treatment after improved oxygen monitoring (2011) in a Mexican preterm population selected for WINROP analyses and to retrospectively revalidate WINROP, an online surveillance system identifying infants at risk of developing ROP type 1.
  
  
  
  Preterm infants born with birth weight (BW) <1,750 g and/or at gestational age (GA) ≤34 weeks, screened for ROP in 2012-2014 at the Hospital Civil de Guadalajara, Mexico were included (n = 151). Eighty-five infants with GA <32 weeks qualified for WINROP analyses. GA, BW, maximal ROP stage, ROP treatment and weekly weights were recorded. The results in the present study were compared to those of a previous WINROP study in the same hospital (2005-2010; n = 352).
  
  
  
  In the present WINROP cohort, 11.8% of the infants born at GA <32 weeks received treatment compared to 51.0% of the infants in the previous WINROP cohort. One infant (3%) born at GA ≥32 weeks received treatment during the present study period compared to 35.6% during the previous period. WINROP displayed 80.0% sensitivity in infants born at GA <32 weeks in the present study compared to 84.7% in the previous study.
  
  
  
  Uncontrolled oxygen supplementation is the major risk factor for severe ROP in infants born at GA ≥32 weeks. After improved oxygen monitoring, the frequency of ROP treatment was dramatically reduced at the Hospital Civil de Guadalajara, Mexico.
authors.affiliation: Clinic of Retinopathy of Prematurity and Blindness Prevention, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
authors.forename: Luz Consuelo
authors.initials: LC
authors.lastname: Zepeda-Romero
authors.forename: Pia
authors.initials: P
authors.lastname: Lundgren
authors.forename: Jose Alfonso
authors.initials: JA
authors.lastname: Gutierrez-Padilla
authors.forename: Larissa Maria
authors.initials: LM
authors.lastname: Gomez-Ruiz
authors.forename: Moises
authors.initials: M
authors.lastname: Quiles Corona
authors.forename: José Víctor
authors.initials: JV
authors.lastname: Orozco-Monroy
authors.forename: Andrea
authors.initials: A
authors.lastname: Barragan-Sánchez
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Razo-Cervantes
authors.forename: Chatarina
authors.initials: C
authors.lastname: Löfqvist
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Hård
authors.forename: Ann
authors.initials: A
authors.lastname: Hellström
mesh_terms: D000465:Algorithms; D005865:Gestational Age; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D008297:Male; D008800:Mexico / Q000453:epidemiology; D015997:Neonatal Screening; D010100:Oxygen / Q000009:adverse effects* / Q000627:therapeutic use; D012178:Retinopathy of Prematurity / Q000453:epidemiology* / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D010100:Oxygen