title: Does vitamin D deficiency trigger carpal tunnel syndrome?
abstract: OBJECTIVE
  Vitamin D deficiencies are associated with a variety of chronic diseases. The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS).
  
  
  METHODS
  This study included 90 patients with mild to moderate CTS and assessed their routine serum 25-hydroxyvitamin D levels. Additionally, the pain level of each subject was evaluated using the Visual Analogue Scale and the Douleur Neuropathique 4 Questionnaire (DN4).
  
  
  RESULTS
  The severity levels of CTS were at a 75% mild level in the vitamin D deficiency group and a 47.1% mild level in the vitamin D normal group, with a significant difference between groups (p = 0.008). Correlation analyses revealed positive correlations between body mass index and DN4 scores (r = 0.499, p = 0.025) and between vitamin D levels and CTS severity (r = 0.364, p = 0.004) in the vitamin D deficiency group.
  
  
  CONCLUSIONS
  The present findings demonstrated that CTS may be triggered by vitamin D deficiency, and that the severity of CTS was correlated with vitamin D levels in the deficiency group. Additionally, there was a correlation between weight gain and neuropathic pain intensity in CTS patients with vitamin D deficiency. The present findings indicate that vitamin D levels should be assessed in CTS patients.
authors.affiliation: Department of Neurology, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Tanik
authors.affiliation: Department of Physical Treatment and Rehabilitation, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Balbaloğlu
authors.affiliation: Department of Physical Treatment and Rehabilitation, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ucar
authors.affiliation: Department of Physical Medicine and Rehabilitation, Yozgat State Hospital, Yozgat, Turkey.
authors.forename: Umıt
authors.initials: U
authors.lastname: Sarp
authors.affiliation: Department of Neurosurgery, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Tugay
authors.initials: T
authors.lastname: Atalay
authors.affiliation: Department of Neurology, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Çelikbilek
authors.affiliation: Department of Biochemistry, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Ayşe Yeşim
authors.initials: AY
authors.lastname: Göçmen
authors.affiliation: Department of Neurology, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Levent Ertugrul
authors.initials: LE
authors.lastname: Inan
mesh_terms: D002349:Carpal Tunnel Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000150:complications; D012720:Severity of Illness Index; D064232:Visual Analog Scale; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications*; D015430:Weight Gain
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-Dihydroxyvitamin; carpal tunnel syndrome; neuropathic pain 