title: [INFLUENCE OF QUINAPRIL IN COMBINATION WITH ANGIOLINE ON THE CONNECTIVE TISSUE COMPONENTS IN THE RATS SERUM WITH EXPERIMENTAL HYPERTENSION].
abstract: One of the most active inhibitors angiotensin-converting enzyme is quinapril that has a high affinity for tissue ACE, improves endothelial vasodilation, has a wide therapeutic range and beneficient influence on heart rate. A new biological active compound with antioxidant action that has endothelioprotective, cardioprotective, antiischemic action is angiolin. In experimental arterial hypertension in the animals blood serum the activity of collagenase, the content of free and protein connecting fractions of hydroxyproline and indicators that reflect the metabolism of glycosaminoglycans have been increased. Angiolin increases the activity of collagenase free and protein connecting fractions of hydroxyproline comparing to control. Concentration glycosoaminoglycan (GAG) also exceeds the standard data. Quinapril has similar to angiolin action directed effect to the connective tissue components, though losing as proteinconecting of hydroxiproline action. Cooperative application quinapril with angioline most effectively influence the metabolic processes stabilization in experimental animals.
authors.forename: A A
authors.initials: AA
authors.lastname: Nagornaya
authors.forename: S
authors.initials: S
authors.lastname: Magomedov
authors.forename: N A
authors.initials: NA
authors.lastname: Gorchakova
authors.forename: I F
authors.initials: IF
authors.lastname: Belenichev
authors.forename: I S
authors.initials: IS
authors.lastname: Ghekman
authors.forename: T A
authors.initials: TA
authors.lastname: Kuzub
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D017364:Collagenases / Q000097:blood; D003238:Connective Tissue / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D004338:Drug Combinations; D004357:Drug Synergism; D006025:Glycosaminoglycans / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006909:Hydroxyproline / Q000097:blood; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D000077583:Quinapril; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D044005:Tetrahydroisoquinolines / Q000494:pharmacology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D000975:Antioxidants; D004338:Drug Combinations; D006025:Glycosaminoglycans; D044005:Tetrahydroisoquinolines; D007703:Peptidyl-Dipeptidase A; D017364:Collagenases; D000077583:Quinapril; D006909:Hydroxyproline