title: Innate immune cell response upon Candida albicans infection.
abstract: Candida albicans is a polymorphic fungus which is the predominant cause of superficial and deep tissue fungal infections. This microorganism has developed efficient strategies to invade the host and evade host defense systems. However, the host immune system will be prepared for defense against the microbe by recognition of receptors, activation of signal transduction pathways and cooperation of immune cells. As a consequence, C. albicans could either be eliminated by immune cells rapidly or disseminate hematogenously, leading to life-threatening systemic infections. The interplay between Candida albicans and the host is complex, requiring recognition of the invaded pathogens, activation of intricate pathways and collaboration of various immune cells. In this review, we will focus on the effects of innate immunity that emphasize the first line protection of host defense against invaded C. albicans including the basis of receptor-mediated recognition and the mechanisms of cell-mediated immunity.
authors.affiliation: a Research and Develop Center of New Drug, School of Pharmacy, Second Military Medical University , Shanghai , China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Qin
authors.affiliation: a Research and Develop Center of New Drug, School of Pharmacy, Second Military Medical University , Shanghai , China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Research and Develop Center of New Drug, School of Pharmacy, Second Military Medical University , Shanghai , China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: a Research and Develop Center of New Drug, School of Pharmacy, Second Military Medical University , Shanghai , China.
authors.forename: Jinyu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Research and Develop Center of New Drug, School of Pharmacy, Second Military Medical University , Shanghai , China.
authors.forename: Yuan-Ying
authors.initials: YY
authors.lastname: Jiang
authors.affiliation: a Research and Develop Center of New Drug, School of Pharmacy, Second Military Medical University , Shanghai , China.
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Cao
authors.affiliation: b Department of Pharmacology , School of Pharmacy, China Pharmaceutical University , Nanjing , China.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Yan
mesh_terms: D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D051192:Receptors, Pattern Recognition
keywords: Candida albicans; immune cells; innate immunity; receptor-mediated recognition; signal transduction