title: Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review.
abstract: Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to standardize a treatment protocol. One of the controversial points is the decision whether or not to perform an elective neck dissection on these patients. Because there is contradictory information about this issue, we have critically reviewed the literature from 1912 to 2015 on all reported cases of AdCC of the larynx in order to clarify this issue. During the most recent period of our review (1991-2015) with a more exact diagnosis of the tumor histology, 142 cases were observed of AdCC of the larynx, of which 91 patients had data pertaining to lymph node status. Eleven of the 91 patients (12.1%) had nodal metastasis and, based on this low proportion of patients, routine elective neck dissection is therefore not recommended.
authors.affiliation: Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Andrés
authors.initials: A
authors.lastname: Coca-Pelaz
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Leon
authors.initials: L
authors.lastname: Barnes
authors.affiliation: University of Udine School of Medicine, Udine, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.affiliation: Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cardesa
authors.affiliation: Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Jatin P
authors.initials: JP
authors.lastname: Shah
authors.affiliation: Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.|Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Rodrigo
authors.affiliation: Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.|Fundación de Investigación e Innovación Biosanitaria del Principado de Asturias, Oviedo, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, USA.
authors.forename: Jean Anderson
authors.initials: JA
authors.lastname: Eloy
authors.affiliation: Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Bishop
authors.affiliation: Department of Pathology, Allegiance Health, Jackson, MI, USA.
authors.forename: Kenneth O
authors.initials: KO
authors.lastname: Devaney
authors.affiliation: Southern California Permanente Medical Group, Woodland Hills, CA, USA.
authors.forename: Lester D R
authors.initials: LD
authors.lastname: Thompson
authors.affiliation: Department of Pathology, Beth Israel Medical Center, New York, NY, USA.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Wenig
authors.affiliation: Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
authors.forename: Primož
authors.initials: P
authors.lastname: Strojan
authors.affiliation: Department of Head and Neck Surgery, Head and Neck Oncology Program, St Luc University Hospital and King Albert II Cancer Institute, Brussels, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Hamoir
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham, UK.|European Salivary Gland Society, Geneva, Switzerland.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Bradley
authors.affiliation: University Pathologists, Providence, RI, USA.|University Pathologists, Fall River, MA, USA.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Gnepp
authors.affiliation: Departments of Surgery and Otolaryngology - Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
authors.forename: Carl E
authors.initials: CE
authors.lastname: Silver
authors.affiliation: Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: Slootweg
authors.affiliation: Oral and Maxillofacial Pathology, School of Dentistry, University of Liverpool and Cellular Pathology, Liverpool Clinical Laboratories, Liverpool, UK.
authors.forename: Asterios
authors.initials: A
authors.lastname: Triantafyllou
authors.affiliation: European Salivary Gland Society, Geneva, Switzerland.|Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Vander Poorten
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Williams
authors.affiliation: Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic.
authors.forename: Alena
authors.initials: A
authors.lastname: Skálová
authors.affiliation: Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hellquist
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Philipp University, Marburg, Germany.
authors.forename: Afshin
authors.initials: A
authors.lastname: Teymoortash
authors.affiliation: Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Jesus E
authors.initials: JE
authors.lastname: Medina
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: K Thomas
authors.initials: KT
authors.lastname: Robbins
authors.affiliation: Department of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.
authors.forename: Karen T
authors.initials: KT
authors.lastname: Pitman
authors.affiliation: Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
authors.forename: Luiz P
authors.initials: LP
authors.lastname: Kowalski
authors.affiliation: Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Remco
authors.initials: R
authors.lastname: de Bree
authors.affiliation: Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
authors.affiliation: Coordinator of the International Head and Neck Scientific Group, Padua, Italy. a.ferlito@uniud.it.
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000601:surgery; D017558:Elective Surgical Procedures / Q000379:methods; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D037981:Neck Dissection / Q000379:methods*; D018579:Patient Selection
keywords: Adenoid cystic carcinoma; Clinical protocols; Elective neck dissection; Larynx; Lymph node metastasis; Neck; Oncology; Treatment