title: Myeloid-Derived Suppressor Cells in Bacterial Infections.
abstract: Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.
authors.affiliation: Children's Hospital, University of Tübingen Tübingen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Ost
authors.affiliation: Children's Hospital, University of Tübingen Tübingen, Germany.
authors.forename: Anurag
authors.initials: A
authors.lastname: Singh
authors.affiliation: Infection Biology Department, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen Tübingen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Peschel
authors.affiliation: Children's Hospital, University of Tübingen Tübingen, Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Mehling
authors.affiliation: Children's Hospital, University of TübingenTübingen, Germany; Department of Pediatrics, Kinderklinik München Schwabing, Klinikum Schwabing, StKM GmbH und Klinikum rechts der Isar, Technische Universität MünchenMunich, Germany.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Rieber
authors.affiliation: Children's Hospital, University of Tübingen Tübingen, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Hartl
mesh_terms: D001424:Bacterial Infections / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
keywords: MDSC; bacteria; immune suppression; infection; myeloid-derived suppressor cells; sepsis