title: B0-adjusted and sensitivity-encoded spectral localization by imaging (BASE-SLIM) in the human brain in vivo.
abstract: Spectral localization by imaging (SLIM) based magnetic resonance spectroscopy (MRS) provides a framework that overcomes major limitations of current MRS techniques, which allow only rectangular voxel shapes that do not conform to the shapes of brain structures or lesions. However, the restrictive assumption of compartmental homogeneity in SLIM can lead to localization errors, thus its applications have been very limited to date. SLIM-based localization is subject to errors due to inhomogeneous B0 and B1 fields, particularly in organs with complex compartmental geometry including the human brain. The limitations of SLIM were overcome through the development and implementation of B0-adjusted and sensitivity-encoded SLIM (BASE-SLIM) that includes corrections for inhomogeneities of both B0 and B1 fields throughout the volume of interest. In this study, we demonstrate significantly improved localization accuracy in compartments with arbitrary shapes and reliable quantification of metabolite concentrations in gray and white matter of the human brain using the BASE-SLIM technique.
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Adany
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA; Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA; Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors.forename: In-Young
authors.initials: IY
authors.lastname: Choi
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA; Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address: plee2@kumc.edu.
authors.forename: Phil
authors.initials: P
authors.lastname: Lee
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000378:metabolism*; D005260:Female; D066128:Gray Matter / Q000378:metabolism*; D006801:Humans; D008297:Male; D057054:Molecular Imaging / Q000379:methods; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D014018:Tissue Distribution; D066127:White Matter / Q000378:metabolism*
keywords: Compartmental inhomogeneity; Gray matter; Human brain; Magnetic resonance spectroscopy; Spectral localization by imaging; White matter