title: TEMPO-oxidized Konjac glucomannan as appliance for the preparation of hard capsules.
abstract: TEMPO-oxidized Konjac glucomannan (OKGM) was developed as new material for preparing vegetarian hard capsules. OKGM of different degrees of oxidation: DO30%, DO50%, and DO80% were prepared to select optimum DO for capsule formation. FT-IR results proved that the primary alcohol groups on KGM were oxidized into carboxyl groups. XRD analysis suggested that TEMPO-oxidation decreased the crystallinity of KGM. DO80% was considered as the optimum candidate for capsule preparation owing to its superior solubility, transparency and reduced viscosity. The hydrophilicity of OKGM films, measured by contact angle measurement, increased with increasing DO. The elongation at break and tensile strength of the OKGM films enhanced with increasing DO. In vitro drug dissolution profile of OKGM capsules showed that the shell rupture time of DO80% capsule is about 5-10 min, and 80% of the drugs were released within 30-45 min. Thus DO80% OKGM was qualified to be used for gastric soluble hard capsules.
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Zhao
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Xianwu
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Zusen
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Jiande
authors.initials: J
authors.lastname: Wu
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Mengxuan
authors.initials: M
authors.lastname: Shi
authors.affiliation: Laboratory of Physical Chemistry and Colloid Science, Wageningen University, Dreijenplein 6, Wageningen 6703 HB, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: Norde
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address: liyuan@mail.buct.edu.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D031056:Amorphophallus; D002214:Capsules; D065546:Drug Liberation; D004917:Erythromycin / Q000031:analogs & derivatives / Q000737:chemistry; D008351:Mannans / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D010880:Piperidines / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D014783:Viscosity; D044902:beta-Mannosidase / Q000737:chemistry
chemical_list: C528764:2,2,6,6-tetramethyl-1-piperidine; D002214:Capsules; D008351:Mannans; D010880:Piperidines; C022901:(1-6)-alpha-glucomannan; D004917:Erythromycin; D044902:beta-Mannosidase; C011462:erythromycin stearate
keywords: 2,2,6,6-tetramethyl-1-piperidinyloxy (PubChem CID:2724126); Carrageenan (PubChem CID:6850766); Disintegration time; Erythromycin stearate (PubChem CID:12559); In vitro dissolution; Konjac glucomannan; Plant-derived hard capsules; Sodium hydroxide (PubChem CID:14798); Sodium hypochlorite (PubChem CID:23665760); TEMPO-oxidation