title: Sleep Disordered Breathing and White Matter Hyperintensities in Community-Dwelling Elders.
abstract: OBJECTIVE
  To examine the association between markers of sleep-disordered breathing (SDB) and white matter hyperintensity (WMH) volume in an elderly, multiethnic, community-dwelling cohort.
  
  
  METHODS
  This is a cross-sectional analysis from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a community-based epidemiological study of older adults. Structural magnetic resonance imaging was obtained starting in 2004; the Medical Outcomes Study-Sleep Scale (MOS-SS) was administered to participants starting in 2007. Linear regression models were used to assess the relationship between the two MOS-SS questions that measure respiratory dysfunction during sleep and quantified WMH volume among WHICAP participants with brain imaging.
  
  
  RESULTS
  A total of 483 older adults had both structural magnetic resonance imaging and sleep assessment. Self-reported SDB was associated with WMH. After adjusting for demographic and vascular risk factors, WMH volumes were larger in individuals with frequent snoring (β = 2.113, P = 0.004) and among those who reported waking short of breath or with headache (β = 1.862, P = 0.048).
  
  
  CONCLUSIONS
  In community-dwelling older adults, self-reported measures of SDB are associated with larger WMH volumes. The cognitive effects of SDB that are increasingly being recognized may be mediated at the small vessel level.
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Sara K
authors.initials: SK
authors.lastname: Rostanski
authors.affiliation: Department of Psychology, Fordham University, Bronx, NY.|Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.
authors.forename: Molly E
authors.initials: ME
authors.lastname: Zimmerman
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY.|The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Nicole
authors.initials: N
authors.lastname: Schupf
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.|The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Manly
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Westwood
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.|The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.|The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Yian
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D001921:Brain / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006261:Headache / Q000150:complications / Q000473:pathology; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D009519:New York City; D017286:Polysomnography; D012111:Residence Characteristics; D012307:Risk Factors; D057566:Self Report; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000473:pathology*; D012913:Snoring / Q000150:complications / Q000473:pathology; D066127:White Matter / Q000473:pathology*
keywords: cerebrovascular disease; cognition; sleep disordered breathing