title: Locoregional treatment of early breast cancer with isolated tumor cells or micrometastases on sentinel lymph node biopsy.
abstract: The advent of sentinel lymph-node technique has led to a shift in lymph-node staging, due to the emergence of new entities namely micrometastases (pN1mi) and isolated tumor cells [pN0(i+)]. The prognostic significance of this low positivity in axillary lymph nodes is currently debated, as is, therefore its management. This article provides updates evidence-based medicine data to take into account for treatment decision-making in this setting, discussing the locoregional treatment in pN0(i+) and pN1mi patients (completion axillary dissection, axillary irradiation with or without regional nodes irradiation, or observation), according to systemic treatment, with the goal to help physicians in their daily practice.
authors.affiliation: Agnès Tallet, Mathieu Minsat, Michel Resbeut, Departement of Radiotherapy, Institut Paoli Calmettes and CRCM, 13009 Marseille, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Tallet
authors.affiliation: Agnès Tallet, Mathieu Minsat, Michel Resbeut, Departement of Radiotherapy, Institut Paoli Calmettes and CRCM, 13009 Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Lambaudie
authors.affiliation: Agnès Tallet, Mathieu Minsat, Michel Resbeut, Departement of Radiotherapy, Institut Paoli Calmettes and CRCM, 13009 Marseille, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Cohen
authors.affiliation: Agnès Tallet, Mathieu Minsat, Michel Resbeut, Departement of Radiotherapy, Institut Paoli Calmettes and CRCM, 13009 Marseille, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Minsat
authors.affiliation: Agnès Tallet, Mathieu Minsat, Michel Resbeut, Departement of Radiotherapy, Institut Paoli Calmettes and CRCM, 13009 Marseille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Bannier
authors.affiliation: Agnès Tallet, Mathieu Minsat, Michel Resbeut, Departement of Radiotherapy, Institut Paoli Calmettes and CRCM, 13009 Marseille, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Resbeut
authors.affiliation: Agnès Tallet, Mathieu Minsat, Michel Resbeut, Departement of Radiotherapy, Institut Paoli Calmettes and CRCM, 13009 Marseille, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Houvenaeghel
keywords: Axillary lymph node dissection; Breast cancer; Isolated tumor cells; Micrometastases; Radiotherapy