title: Preoperative Gross Classification of Gastric Adenocarcinoma: Comparison of Double Contrast-Enhanced Ultrasound and Multi-Detector Row CT.
abstract: The aim of this study was to compare the accuracy of multi-detector computed tomography (MDCT) with double contrast-enhanced ultrasound (DCEUS), in which intravenous microbubbles are used alongside oral contrast-enhanced ultrasound, in determining the gross classification of patients with gastric carcinoma (GC). Altogether, 239 patients with GC proved by histology after endoscopic biopsy were included in this study. DCEUS and MDCT were performed pre-operatively. The diagnostic accuracies of DCEUS and MDCT in determining the gross classification were calculated and compared. The overall accuracy of DCEUS in determining the gross appearance of GC was higher than that of MDCT (84.9% vs. 79.9%, p < 0.001). There was no significant difference in accuracy between DCEUS and MDCT for Borrmann I and IV classifications of advanced gastric cancer (χ(2), p = 0.323 for Borrmann type I, p = 0.141 for Borrmann type IV). The accuracy of DCEUS for early GC and Borrmann II and III classifications of GC was higher than that of MDCT (χ(2), p = 0.000 for all). DCEUS may be regarded as a valuable complementary tool to MDCT in determining the gross appearance of gastric adenocarcinoma pre-operatively.
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Caoxin
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Bao
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Weihui
authors.initials: W
authors.lastname: Shentu
authors.affiliation: Department of Surgery, The 2nd Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pathology, The 2nd Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Liuhong
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Yangbin
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China. Electronic address: huangpintong@126.com.
authors.forename: Pintong
authors.initials: P
authors.lastname: Huang
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D045423:Microbubbles; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D015203:Reproducibility of Results; D013270:Stomach / Q000000981:diagnostic imaging; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging*; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: Borrmann classification; Computed tomography; Contrast; Gastric neoplasms; Microbubbles; Ultrasonography