title: Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice.
abstract: Pine polyphenols (PPs) are bioactive dietary constituents that enhance health and help prevent diseases through antioxidants. Antioxidants reduce the level of oxidative damages caused by ionizing radiation (IR). The main purpose of this paper is to study the protective effect of PPs on peripheral blood, liver and spleen injuries in mice induced by IR. ICR (Institute of Cancer Research) male mice were administered orally with PPs (200 mg/kg b.wt.) once daily for 14 consecutive days prior to 7 Gy γ-radiations. PPs showed strong antioxidant activities. PPs significantly increased white blood cells, red blood cells and platelets counts. PPs also significantly reduced lipid peroxidation and increased the activities of superoxide dismutase, catalase and glutathione peroxidases, and the level of glutathione. PPs reduced the spleen morphologic injury. In addition, PPs inhibited mitochondria-dependent apoptosis pathways in splenocytes induced by IR. These results indicate that PPs are radioprotective promising reagents.
authors.affiliation: School of Chemistry and Chemical Engineering, Harbin Institute of Technology , Harbin, Heilongjiang , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Harbin Institute of Technology , Harbin, Heilongjiang , China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Pharmaceutical Academy of Harbin Pharmaceutical Group , Harbin, Heilongjiang , China.
authors.forename: Yier
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, The Fourth Hospital Affiliated to Nanchang University , Nanchang, Jiangxi , China.
authors.forename: Guicai
authors.initials: G
authors.lastname: Sun
keywords: Antioxidant; Apoptosis; Pine polyphenols; Redox; γ-radiation