title: CAF cellular glycolysis: linking cancer cells with the microenvironment.
abstract: Cancers have long being hallmarked as cells relying heavily on their glycolysis for energy generation in spite of having functional mitochondria. The metabolic status of the cancer cells have been revisited time and again to get better insight into the overall carcinogenesis process which revealed the apparent crosstalks between the cancer cells with the fibroblasts present in the tumour microenvironment. This review focuses on the mechanisms of transformations of normal fibroblasts to cancer-associated fibroblasts (CAF), the participation of the CAF in tumour progression with special interest to the role of CAF cellular glycolysis in the overall tumorigenesis. The fibroblasts, when undergoes the transformation process, distinctly switches to a more glycolytic phenotype in order to provide the metabolic intermediates necessary for carrying out the mitochondrial pathways of ATP generation in cancer cells. This review will also discuss the molecular mechanisms responsible for this metabolic make over promoting glycolysis in CAF cells. A thorough investigation of the pathways and molecules involved will not only help in understanding the process of activation and metabolic reprogramming in CAF cells but also might open up new targets for cancer therapy.
authors.affiliation: School of Life Sciences, B. S. Abdur Rahman University, Vandalur, Chennai, Tamil Nadu, 600048, India. amritaroy.sls@bsauniv.ac.in.
authors.forename: Amrita
authors.initials: A
authors.lastname: Roy
authors.affiliation: School of Life Sciences, B. S. Abdur Rahman University, Vandalur, Chennai, Tamil Nadu, 600048, India.
authors.forename: Soumen
authors.initials: S
authors.lastname: Bera
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005347:Fibroblasts / Q000473:pathology*; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment
keywords: Cancer associated fibroblast; Glycolysis; Metabolism; Tumour microenvironment