title: Role of the Gram-Negative Envelope Stress Response in the Presence of Antimicrobial Agents.
abstract: Bacterial survival necessitates endurance of many types of antimicrobial compound. Many Gram-negative envelope stress responses, which must contend with an outer membrane and a dense periplasm containing the cell wall, have been associated with the status of protein folding, membrane homeostasis, and physiological functions such as efflux and the proton motive force (PMF). In this review, we discuss evidence that indicates an emerging role for Gram-negative envelope stress responses in enduring exposure to diverse antimicrobial substances, focusing on recent studies of the γ-proteobacterial Cpx envelope stress response.
authors.affiliation: Department of Biological Sciences, University of Alberta, Edmonton, AB Canada T6G 2E9.
authors.forename: Randi L
authors.initials: RL
authors.lastname: Guest
authors.affiliation: Department of Biological Sciences, University of Alberta, Edmonton, AB Canada T6G 2E9. Electronic address: traivio@ualberta.ca.
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Raivio
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D002473:Cell Wall / Q000187:drug effects / Q000502:physiology; D004777:Environment; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology; D018892:Proton-Motive Force / Q000502:physiology; D015398:Signal Transduction; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D011494:Protein Kinases; C092472:CpxA protein, bacteria
keywords: antibiotic; antimicrobial; bacteriocin; bacteriophage; envelope stress; resistance