title: CD133+ cancer stem-like cells promote migration and invasion of salivary adenoid cystic carcinoma by inducing vasculogenic mimicry formation.
abstract: Cancer stem cells (CSCs) have gained much attention due to their roles in the invasion and metastasis of numerous kinds of human cancers. Here, we showed that the positive expression of CD133, the stemness marker, was positively associated with vasculogenic mimicry (VM) formation, local regional recurrence, distant metastasis and poorer prognosis in salivary adenoid cystic carcinoma (ACC) specimens. Compared with CD133- ACC cells, CD133+ cancer stem-like cells had more migration and invasion capabilities, as well as more VM formation. The levels of endothelial cell marker VE-cadherin, MMP-2 and MMP-9 expression in CD133+ cancer stem-like cells and xenograft tumors of nude mice injected with CD133+ cells were significantly higher than those with CD133- cells. The data indicated that CD133+ cancer stem-like cells might contribute to the migration and invasion of ACC through inducing VM formation.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Shi-Yu
authors.initials: SY
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Xiang-Rui
authors.initials: XR
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Qian-Ming
authors.initials: QM
authors.lastname: Chen
authors.affiliation: Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, People's Republic of China.
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.|Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.|Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Liang
mesh_terms: D000071916:AC133 Antigen / Q000378:metabolism; D000328:Adult; D000368:Aged; D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D064593:Heterografts; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology*
chemical_list: D000071916:AC133 Antigen; C000606023:PROM1 protein, human
keywords: adenoid cystic carcinoma (ACC); invasion; metastasis; salivary gland; vasculogenic mimicry (VM)