title: Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study.
abstract: Schwannomas are tumors derived from Schwann cells. Generally, they are benign and their typical site of origin is the subcutaneous tissue of the distal extremities or of the head and neck region. Gastrointestinal localization of schwannomas is extremely rare, and the stomach is the prevalent site. The present study describes the case of a gastric schwannoma in a 61-year-old male who underwent subtotal gastrectomy following a clinical diagnosis of a gastrointestinal stromal tumor (GIST). A histological, immunohistochemical and molecular study was performed to exclude the misdiagnosis of GIST. The histomorphological features of the lesion and absence of c-Kit and PDGFRA mutations indicated the diagnosis of gastric schwannoma.
authors.affiliation: Pathology Unit, National Cancer Institute 'G. Pascale' Foundation, Naples, Campania 80131, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Tatangelo
authors.affiliation: Pathology Unit, National Cancer Institute 'G. Pascale' Foundation, Naples, Campania 80131, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Cantile
authors.affiliation: Pathology Unit, National Cancer Institute 'G. Pascale' Foundation, Naples, Campania 80131, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Collina
authors.affiliation: Department of General and Hepato-Pancreato-Biliary Surgery, National Cancer Institute 'G. Pascale' Foundation, Naples, Campania 80131, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Belli
authors.affiliation: Department of General and Hepato-Pancreato-Biliary Surgery, National Cancer Institute 'G. Pascale' Foundation, Naples, Campania 80131, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: DE Franciscis
authors.affiliation: Department of General and Hepato-Pancreato-Biliary Surgery, National Cancer Institute 'G. Pascale' Foundation, Naples, Campania 80131, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Bianco
authors.affiliation: Pathology Unit, National Cancer Institute 'G. Pascale' Foundation, Naples, Campania 80131, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
keywords: gastric schwannoma; gastrointestinal stromal tumor; immunohistochemical and molecular study