title: Evaluation of cost effective diagnostic tools in characterisation of Acute Leukemia in Southern India.
abstract: The incidence of Acute Leukemia (AL) subtypes varies according to geographical distribution and more predominant in developing countries. The aim here was to evaluate the usefulness of cost effective diagnostic tools in characterization of Acute Lymphoblastic Leukemia (ALL) in resource poor population. One hundred and two AL cases were diagnosed. For diagnosis, cytochemical analysis and immunohistochemistry were performed. Among the children < 12 years, ALL was 64.3% while AML accounted for 30%. In patients > 12 years, ALL was 59.4% and AML was 31.3%. The B-ALL occurred most frequently than T-ALL in both the age groups while based on immunophenotyping in AML, CD13 was the most commonly expressed antigen. Hence, cost effective diagnostic tools namely the immunophenotyping and cytochemistry are useful and improve accuracy and rapidly risk-stratify patients that were diagnosed with acute leukemia.
authors.affiliation: Department of Pathology, Dr. ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
authors.forename: N S
authors.initials: NS
authors.lastname: Sanddhya
authors.affiliation: Department of Pathology, Dr. ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
authors.forename: D
authors.initials: D
authors.lastname: Kathick
authors.affiliation: Department of Pathology, Dr. ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
authors.forename: P
authors.initials: P
authors.lastname: Sachdanandam
authors.affiliation: Department of Hematology Oncology, Institute of Child Health and Hospital for Children, Egmore, Chennai, India.
authors.forename: S
authors.initials: S
authors.lastname: Thilagavathy
authors.affiliation: Department of Pathology, Dr. ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
authors.forename: P
authors.initials: P
authors.lastname: Shanthi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003584:Cytological Techniques / Q000191:economics* / Q000379:methods*; D003906:Developing Countries; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D016130:Immunophenotyping; D007194:India; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology; D011971:Receptors, Immunologic / Q000276:immunology
chemical_list: D011971:Receptors, Immunologic
keywords: Acute leukemia; CD markers; cytochemistry; immunophenotyping