title: Metabolic syndrome and metabolic risk profile according to polycystic ovary syndrome phenotype.
abstract: OBJECTIVE
  It is unknown which phenotype of polycystic ovary syndrome (PCOS) has a greater metabolic risk and how to detect this risk. The aim of this study was therefore to compare the incidence of metabolic syndrome (MetS) and metabolic risk profile (MRP) for different phenotypes.
  
  
  METHODS
  A total of 100 consecutive newly diagnosed PCOS women in a tertiary referral hospital were recruited. Patients were classified into four phenotypes according to the Rotterdam criteria, on the presence of at least two of the three criteria hyperandrogenism (H), oligo/anovulation (O) and PCO appearance (P): phenotype A, H + O + P; phenotype B, H + O; phenotype C, H + P; phenotype D, O + P. Prevalence of MetS and MRP were compared among the four groups.
  
  
  RESULTS
  Based on Natural Cholesterol Education Program Adult Treatment Panel III diagnostic criteria, MetS prevalence was higher in phenotypes A and B (29.6% and 34.5%) compared with the other phenotypes (10.0% and 8.3%; P < 0.001). Although the prevalence of obesity was similar, the number of patients with homeostatic model assessment insulin resistance index (HOMA-IR) >3.8 was significantly higher in androgenic PCOS phenotypes. After logistic regression analysis, visceral adiposity index (VAI) was the only independent predictor of MetS in PCOS (P = 0.002). VAI was also significantly higher in phenotype B, when compared with the others (P < 0.01).
  
  
  CONCLUSIONS
  Phenotypes A and B had the highest risk of MetS among the four phenotypes, and VAI may be a predictor of metabolic risk in PCOS women.
authors.affiliation: Department of Reproductive Medicine and Infertility, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Enes
authors.initials: E
authors.lastname: Bil
authors.affiliation: Department of Reproductive Medicine and Infertility, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Berna
authors.initials: B
authors.lastname: Dilbaz
authors.affiliation: Department of Reproductive Medicine and Infertility, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Derya Akdag
authors.initials: DA
authors.lastname: Cirik
authors.affiliation: Department of Reproductive Medicine and Infertility, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Runa
authors.initials: R
authors.lastname: Ozelci
authors.affiliation: Department of Reproductive Medicine and Infertility, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Enis
authors.initials: E
authors.lastname: Ozkaya
authors.affiliation: Department of Reproductive Medicine and Infertility, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Dilbaz
mesh_terms: D000328:Adult; D000858:Anovulation / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D055442:Metabolome; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism*; D012307:Risk Factors; D055815:Young Adult
keywords: metabolic syndrome; phenotype; polycystic ovary syndrome; risk factor; visceral adiposity index