title: In vitro and in vivo degradation of potential anti-adhesion materials: Electrospun membranes of poly(ester-amide) based on l-phenylalanine and p-(dioxanone).
abstract: Electrospun membranes of poly(p-dioxanone-co-l-phenylalanine) (PDPA) hold potential as an anti-adhesion material. Since adjustable degradation properties are important for anti-adhesion materials, in this study, the in vitro and in vivo degradation processes of PDPA electrospun membranes were investigated in detail. The morphological analysis of these membranes revealed the main degradation conditions of PDPA membranes. The weight remaining and molecular weight variation showed that the overall degradation rate of the membranes could be adjusted by modulating the molecular structure of the PDPAs. Especially, α-chymotrypsin could catalyze the degradation process of PDPAs. Based on these results, the in vitro degradation mechanism was demonstrated, and confirmed by1H NMR of the hydrolysis products. Finally, the in vivo degradation and biocompatibility of different PDPAs were investigated. The kinetic study showed that the in vitro and in vivo molecular weight loss of PDPAs have the first-order characteristics. The in vivo degradation rate of the most Phe-containing PDPA-3 is the slowest, and this result relates to the biocompatibilities of PDPAs. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1369-1378, 2017.
authors.affiliation: The Chemical Biology Group, Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, China.|Department of Chemistry, School of Basic Medical Science, North Sichuan Medical College Nanchong, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Chemistry, School of Basic Medical Science, North Sichuan Medical College Nanchong, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Chemistry, School of Basic Medical Science, North Sichuan Medical College Nanchong, China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Niu
authors.affiliation: Department of Chemistry, School of Basic Medical Science, North Sichuan Medical College Nanchong, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Chen
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China.
authors.forename: Dongliang
authors.initials: D
authors.lastname: Chen
authors.affiliation: The Chemical Biology Group, Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, China.|Department of Chemistry, School of Basic Medical Science, North Sichuan Medical College Nanchong, China.
authors.forename: Chengyi
authors.initials: C
authors.lastname: Shen
authors.affiliation: The Chemical Biology Group, Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, China.|Department of Chemistry, School of Basic Medical Science, North Sichuan Medical College Nanchong, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhang
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D008422:Materials Testing; D008567:Membranes, Artificial; D010649:Phenylalanine / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; D010649:Phenylalanine
keywords: anti-adhesion membranes; enzymatic degradation; hydrolysis; in vivo degradation; poly(ester-amide)