title: Effect of polycaprolactone/collagen/hUCS microfiber nerve conduit on facial nerve regeneration.
abstract: Nerve conduits have been used to bridge nerve gaps without the donor site morbidity associated with nerve grafting. To fabricate artificial nerve conduits, various biological, synthetic, and natural materials have been applied. In this study, we suggest a new fibrous nerve conduit consisting of PCL microfibers supplemented with collagen and human umbilical cord serum (hUCS). The proposed PCL-based nerve conduit exhibited significantly higher bioactivities in vitro and in vivo, compared to pure PCL and PCL/collagen fibrous conduits. Based on these results, we believe that the PCL/collagen/hUCS fibrous conduit provides more favorable micro-environmental conditions for facial nerve (FN) regeneration and has more therapeutic potential for the regeneration of FN transectional damage than the autograft technique.
authors.affiliation: Department of Otolaryngology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: chulsavio@hanmail.net.
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Jang
authors.affiliation: Department of Biomechatronics, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), Suwon, South Korea.
authors.forename: Hyeongjin
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Biomechatronics, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), Suwon, South Korea.
authors.forename: MinSeong
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Biomechatronics, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), Suwon, South Korea. Electronic address: gkimbme@skku.edu.
authors.forename: GeunHyung
authors.initials: G
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D003094:Collagen / Q000737:chemistry*; D003470:Culture Media; D020220:Facial Nerve Injuries / Q000628:therapy*; D005312:Fetal Blood / Q000502:physiology; D048091:Guided Tissue Regeneration; D006801:Humans; D008297:Male; D008422:Materials Testing; D057139:Nanofibers / Q000737:chemistry*; D009416:Nerve Regeneration; D016716:PC12 Cells; D011091:Polyesters / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003470:Culture Media; D011091:Polyesters; C016240:polycaprolactone; D003094:Collagen
keywords: Facial nerve; Nerve conduit; Polycaprolactone/collagen/human umbilical cord serum