title: Biocompatible Hollow Polydopamine Nanoparticles Loaded Ionic Liquid Enhanced Tumor Microwave Thermal Ablation in Vivo.
abstract: Tumor microwave thermal therapy (MWTT) has attracted more attention because of the minimal damage to body function, convenient manipulation and low complications. Herein, a novel polydopamine (PDA) nanoparticle loading ionic liquids (ILs/PDA) as microwave susceptible agent is introduced for enhancing the selectivity and targeting of MWTT. ILs/PDA nanocomposites have an excellent microwave heating efficiency under an ultralow microwave power irradiation. Encouraging antitumor effect was observed when tumor bearing mice received ILs/PDA nanoparticles by intravenous injection and only single microwave irradiation. PDA nanoparticles with gold nanoparticles in core were constructed for tumor targeting study by ICP-MS and about 15% PDA nanoparticles were founded in tumor. Furthermore, the cytotoxicity and acute toxicity study in vivo of PDA showed the excellent biocompatibility of ILs/PDA nanocomposites. In addition, the degradation of ILs/PDA nanocomposites in simulated body fluid illustrated the low potential hazard when they entered the blood. The emergence of PDA as a novel and feasible platform for cancer thermal therapy will promote the rapid development of microwave therapy in clinics.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
authors.forename: Longfei
authors.initials: L
authors.lastname: Tan
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.|School of Science, Beijing Jiaotong University , No. 3 Shangyuancun Haidian District, Beijing, 100044, P. R. China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Tang
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
authors.forename: Xiangling
authors.initials: X
authors.lastname: Ren
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.affiliation: School of Science, Beijing Jiaotong University , No. 3 Shangyuancun Haidian District, Beijing, 100044, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D007211:Indoles; D052578:Ionic Liquids; D051379:Mice; D008872:Microwaves; D053758:Nanoparticles; D009369:Neoplasms; D011108:Polymers
chemical_list: D007211:Indoles; D052578:Ionic Liquids; D011108:Polymers; C568283:polydopamine
keywords: ionic liquids; microwave susceptible agent; microwave thermal ablation; nanoparticle; polydopamine