title: [SERUM LEVEL OF ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE-II IN CHILDHOOD-ONSET TYPE 1 DIABETIC PATIENTS AND OBESE ADOLESCENTS].
abstract: The atherosclerotic process begins in adolescence, and its progression is determined by the same risk factors as in adults. Endothelial monocyte activating polypeptide-II (EMAP-II) is a multifunctional cytokine with proinflammatory and antiangiogenetic activity that may play a pathogenic role in the development of endothelial dysfunction and atherosclerosis. The aim of our study was to determine the serum level of EMAP-II in childhood-onset type 1 diabetic patients and obese adolescents. We found increased of serum level of EMAP-II in childhood-onset type 1 diabetic patients and in patients with obesity that do not suffer from diabetes. Also, the level of EMAP-II correlated with the serum level of glycosylated hemoglobin and blood glucose, and key markers of lipid metabolism, body mass index. Increased serum level of EMAP-II may be one of the pathway of endothelial dysfunction in type 1 diabetes.
authors.forename: L A
authors.initials: LA
authors.lastname: Mogylnytska
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D016207:Cytokines / Q000097:blood* / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006442:Glycated Hemoglobin / Q000235:genetics / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood* / Q000235:genetics; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D016601:RNA-Binding Proteins / Q000097:blood* / Q000235:genetics; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D016207:Cytokines; D006442:Glycated Hemoglobin; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins; D014280:Triglycerides; C517652:hemoglobin A1c protein, human; C077219:small inducible cytokine subfamily E, member 1