title: Epithelial-Mesenchymal Transition and Immune Evasion during Lung Cancer Progression: The Chicken or the Egg?
abstract: Epithelial-mesenchymal transition (EMT) is a complex process involved in metastasis. Immune evasion is required for tumor progression and is characterized by an ineffective antitumor immune response and upregulation of immune-suppressive signals. The coexistence of EMT and adaptive immune evasion opens the possibility of a mechanistic link between these processes. Clin Cancer Res; 22(14); 3422-4. ©2016 AACRSee related article by Lou et al., p. 3630.
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, Connecticut. Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, Connecticut.
authors.forename: Ila
authors.initials: I
authors.lastname: Datar
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, Connecticut. Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, Connecticut. Medical Oncology, Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut. kurt.schalper@yale.edu.
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Schalper
mesh_terms: D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition / Q000276:immunology* / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D008168:Lung / Q000276:immunology / Q000473:pathology; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology*; D015854:Up-Regulation / Q000276:immunology