title: [Multi-parametric Flow Cytometry for Neuroblastoma, a new and possible diagnostic tool: case report].
abstract: Neuroblastoma is the most frequent extracranial solid tumor in childhood, representing 5.6% according to the "Registro Oncopediatrico Hospitalario Argentino". For its diagnosis, several complementary methods (radiological, biological and biochemical) are required, and Multi-parametric Flow Cytometry (MFC) arises as a potential diagnostic method, despite not having been so far extensively explored. MFC is a method that allows to obtain several information about size, internal complexity and antigenic expression by the use of a laser and fluorescent monoclonal antibodies. There are an increasing number of reports in the literature, which reveal the importance of using MFC for diagnosis and monitoring of solid tumors. The aim in this presentation is to highlight the fundamental role that MFC had in the case of a patient affected by neuroblastoma, in which an early diagnosis using this methodology allowed prompt administration of adequate treatment.
authors.affiliation: Inmunología y Reumatologia, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, C1245AAM, Argentina. belen.manrique@gmail.com.
authors.forename: Belén
authors.initials: B
authors.lastname: Manrique
authors.affiliation: Hemato-Oncologia, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, C1245AAM, Argentina.
authors.forename: Jessica
authors.initials: J
authors.lastname: López Marti
authors.affiliation: Anatomía Patológica, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, C1245AAM, Argentina.
authors.forename: Walter
authors.initials: W
authors.lastname: Cacciavillano
authors.affiliation: Inmunología y Reumatologia, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, C1245AAM, Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Rossi
mesh_terms: D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000175:diagnosis*
keywords: Children; Flow cytometry; Neoplasms; Neuroblastoma; Non-Hematopoietic neoplasms