title: Simultaneous MV-kV imaging for intrafractional motion management during volumetric-modulated arc therapy delivery.
abstract: The purpose of this study was to evaluate the accuracy and clinical feasibility of a motion monitoring method employing simultaneously acquired MV and kV images during volumetric-modulated arc therapy (VMAT). Short-arc digital tomosynthesis (SA-DTS) is used to improve the quality of the MV images that are then combined with orthogonally acquired kV images to assess 3D motion. An anthropomorphic phantom with implanted gold seeds was used to assess accuracy of the method under static, typical prostatic, and respiratory motion scenarios. Automatic registra-tion of kV images and single MV frames or MV SA-DTS reconstructed with arc lengths from 2° to 7° with the appropriate reference fiducial template images was performed using special purpose-built software. Clinical feasibility was evaluated by retrospectively analyzing images acquired over four or five sessions for each of three patients undergoing hypofractionated prostate radiotherapy. The standard deviation of the registration error in phantom using MV SA-DTS was similar to single MV images for the static and prostate motion scenarios (σ = 0.25 mm). Under respiratory motion conditions, the standard deviation of the registration error increased to 0.7mm and 1.7 mm for single MV and MV SA-DTS, respectively. Registration failures were observed with the respiratory scenario only and were due to motion-induced fiducial blurring. For the three patients studied, the mean and standard deviation of the difference between automatic registration using 4° MV SA-DTS and manual registration using single MV images results was 0.07±0.52mm. The MV SA-DTS results in patients were, on average, superior to single-frame MV by nearly 1 mm - significantly more than what was observed in phantom. The best MV SA-DTS results were observed with arc lengths of 3° to 4°. Registration failures in patients using MV SA-DTS were primarily due to blockage of the gold seeds by the MLC. The failure rate varied from 2% to 16%. Combined MV SA-DTS and kV imaging is feasible for intratreatment motion monitoring during VMAT of anatomic sites where limited motion is expected, and improves registration accuracy compared to single MV/kV frames. To create a clinically robust technique, further improvements to ensure visualization of fiducials at the desired control points without degradation of the treatment plan are needed.
authors.affiliation: Memorial Sloan Kettering Cancer Center. huntm@mskcc.org.
authors.forename: Margie A
authors.initials: MA
authors.lastname: Hunt
authors.forename: Mark
authors.initials: M
authors.lastname: Sonnick
authors.forename: Hai
authors.initials: H
authors.lastname: Pham
authors.forename: Rajesh
authors.initials: R
authors.lastname: Regmi
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Xiong
authors.forename: Daniel
authors.initials: D
authors.lastname: Morf
authors.forename: Gig S
authors.initials: GS
authors.lastname: Mageras
authors.forename: Michael
authors.initials: M
authors.lastname: Zelefsky
authors.forename: Pengpeng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D005240:Feasibility Studies; D057918:Fiducial Markers; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D057054:Molecular Imaging / Q000379:methods; D009038:Motion; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies; D012984:Software