title: Microfluidic cell chips for high-throughput drug screening.
abstract: The current state of screening methods for drug discovery is still riddled with several inefficiencies. Although some widely used high-throughput screening platforms may enhance the drug screening process, their cost and oversimplification of cell-drug interactions pose a translational difficulty. Microfluidic cell-chips resolve many issues found in conventional HTS technology, providing benefits such as reduced sample quantity and integration of 3D cell culture physically more representative of the physiological/pathological microenvironment. In this review, we introduce the advantages of microfluidic devices in drug screening, and outline the critical factors which influence device design, highlighting recent innovations and advances in the field including a summary of commercialization efforts on microfluidic cell chips. Future perspectives of microfluidic cell devices are also provided based on considerations of present technological limitations and translational barriers.
authors.affiliation: Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031, USA.
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Chi
authors.affiliation: Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031, USA.
authors.forename: Ah Rezwanuddin
authors.initials: AR
authors.lastname: Ahmed
authors.affiliation: Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031, USA.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Dereli-Korkut
authors.affiliation: Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031, USA.
authors.forename: Sihong
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D057166:High-Throughput Screening Assays / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods
keywords: high-throughput/content screening; microfluidic cell chip; physiological microenvironment