title: Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center.
abstract: A wide variety of neurons, including populations derived from different origins, are precisely arranged and correctly connected with their partner to establish a functional neural circuit during brain development. The molecular mechanisms that orchestrate the production and arrangement of these neurons have been obscure. Here, we demonstrate that cell-cell interactions play an important role in establishing the arrangement of neurons of different origins in the Drosophila visual center. Specific types of neurons born outside the medulla primordium migrate tangentially into the developing medulla cortex. During their tangential migration, these neurons express the repellent ligand Slit, and the two layers that the neurons intercalate between express the receptors Robo2 and Robo3. Genetic analysis suggests that Slit-Robo signaling may control the positioning of the layer cells or their processes to form a path for migration. Our results suggest that conserved axon guidance signaling is involved in the interactions between neurons of different origins during brain development.
authors.affiliation: Brain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Brain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Hasegawa
authors.affiliation: Brain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan; CREST, JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakai
authors.affiliation: Brain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Kaido
authors.affiliation: Brain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan; CREST, JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Takayama
authors.affiliation: Brain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan; Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan; Laboratory of Developmental Neurobiology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan; CREST, JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address: makotos@staff.kanazawa-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sato
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D002465:Cell Movement; D048430:Cell Shape; D029721:Drosophila Proteins / Q000737:chemistry / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology*; D007814:Larva / Q000378:metabolism; D009415:Nerve Net / Q000378:metabolism*; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D000072417:Protein Domains; D011679:Pupa / Q000166:cytology / Q000254:growth & development; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014795:Visual Pathways / Q000166:cytology*
chemical_list: D029721:Drosophila Proteins; D014157:Transcription Factors