title: Factors Influencing Non-sentinel Node Involvement in Sentinel Node Positive Patients and Validation of MSKCC Nomogram in Indian Breast Cancer Population.
abstract: Current guidelines recommend completion axillary lymphnode dissection (ALND) when sentinel lymphnode (SLN) contains metastatic tumor deposit. In consequent ALND sentinel node is the only node involved by tumor in 40-70 % of cases. Recent studies demonstrate the oncologic safety of omitting completion ALND in low risk patients. Several nomograms (MSKCC, Stanford, MD Anderson score, Tenon score) had been developed in predicting the likelihood of additional nodes metastatic involvement. We evaluated accuracy of MSKCC nomogram and other clinicopathologic variables associated with additional lymph node metastasis in our patients. A total of 334 patients with primary breast cancer patients underwent SLN biopsy during the period Jan 2007 to June 2014. Clinicopathologic variables were prospectively collected. Completion ALND was done in 64 patients who had tumor deposit in SLN. The discriminatory accuracy of nomogram was analyzed using Area under Receiver operating characteristic curve (ROC). SLN was the only node involved with tumor in 69 % (44/64) of our patients. Additional lymph node metastasis was seen in 31 % (20/64). On univariate analysis, extracapsular infiltration in sentinel node and multiple sentinel nodes positivity were significantly associated (p < 0.05) with additional lymph node metastasis in the axilla. Area under ROC curve for nomogram was 0.58 suggesting poor performance of the nomogram in predicting NSLN involvement. Sentinel nodes are the only nodes to be involved by tumor in 70 % of the patients. Our findings indicate that multiple sentinel node positivity and extra-capsular invasion in sentinel node significantly predicted the likelihood of additional nodal metastasis. MSKCC nomogram did not reliably predict the involvement of additional nodal metastasis in our study population.
authors.affiliation: Department of Surgery and Surgical Oncology, Apollo Speciality Hospitals, No 320, Padma Complex, Teynampet, Chennai, 600035 India.
authors.forename: Naveen
authors.identifier: 0000-0002-6436-5098
authors.initials: N
authors.lastname: Padmanabhan
authors.affiliation: Department of Surgery and Surgical Oncology, Apollo Speciality Hospitals, No 320, Padma Complex, Teynampet, Chennai, 600035 India.
authors.forename: Muhamed Faizal
authors.initials: MF
authors.lastname: Ayub
authors.affiliation: Department of Surgery and Surgical Oncology, Apollo Speciality Hospitals, No 320, Padma Complex, Teynampet, Chennai, 600035 India.
authors.forename: Khadher
authors.initials: K
authors.lastname: Hussain
authors.affiliation: Department of Pathology, Apollo Speciality Hospitals, No 320, Padma Complex, Teynampet, Chennai, 600035 India.
authors.forename: Ann
authors.initials: A
authors.lastname: Kurien
authors.affiliation: Department of Surgery and Surgical Oncology, Apollo Speciality Hospitals, No 320, Padma Complex, Teynampet, Chennai, 600035 India ; Breast surgery, Chennai Breast Centre, Chennai-28, India.
authors.forename: Selvi
authors.initials: S
authors.lastname: Radhakrishna
keywords: Breast cancer; MSKCC nomogram; Non-sentinel node metastasis; Sentinel node positive