title: Effect of Weight Loss, Diet, Exercise, and Bariatric Surgery on Nonalcoholic Fatty Liver Disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD is the most common liver disease in developed countries. Weight reduction of 3% to 5% is associated with improved steatosis; reductions of 5% to 7% are necessary for decreased inflammation; with 7% to 10%, individuals may experience NAFLD/NASH remission and regression of fibrosis. No specific dietary intervention has proven beneficial beyond calorie restriction. Physical activity without weight loss seems to decrease hepatic steatosis. Bariatric surgery is associated with decreased cardiovascular risk and improved overall mortality in addition to reduction in hepatic steatosis, inflammation, and fibrosis.
authors.affiliation: Department of Medicine, San Antonio Military Medical Center, JBSA, 3551 Roger Brooke Drive, Fort Sam Houston, TX 78234-4504, USA.
authors.forename: William N
authors.initials: WN
authors.lastname: Hannah
authors.affiliation: Division of Gastroenterology, Department of Medicine, San Antonio Military Medical Center, JBSA, 3551 Roger Brooke Drive, Fort Sam Houston, TX 78234-4504, USA. Electronic address: stephen.a.harrison.mil@mail.mil.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Harrison
mesh_terms: D050110:Bariatric Surgery; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D015444:Exercise / Q000502:physiology*; D005632:Fructose / Q000008:administration & dosage; D006801:Humans; D008019:Life Style; D065626:Non-alcoholic Fatty Liver Disease / Q000503:physiopathology* / Q000628:therapy*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D005632:Fructose
keywords: Bariatric surgery; Diet; Exercise; Nonalcoholic fatty liver disease; Weight loss