title: 2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter.
abstract: 2,6-Bis(benzimidazol-2-yl)pyridine was shown to exhibit potent anionophoric activity via a process of both Cl(-)/NO3(-) antiport and H(+)/Cl(-) symport. This is in sharp contrast to the finding that its corresponding N-methylated analog exhibited negligible activity and reveals the importance of the imidazolyl-NH fragments in the anion-transport process.
authors.affiliation: Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Peng
authors.affiliation: Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.affiliation: Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Deng
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, PR China.
authors.forename: Zhuo-Feng
authors.initials: ZF
authors.lastname: Ke
authors.affiliation: Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chen
mesh_terms: D000166:Acridines / Q000378:metabolism; D000838:Anions / Q000378:metabolism*; D001562:Benzimidazoles / Q000737:chemistry / Q000493:pharmacokinetics*; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D009566:Nitrates / Q000378:metabolism; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism; D011725:Pyridines / Q000737:chemistry / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship
chemical_list: C500137:2,6-bis(benzimidazol-2-yl)pyridine; D000166:Acridines; D000838:Anions; D001562:Benzimidazoles; D002712:Chlorides; D009566:Nitrates; D010713:Phosphatidylcholines; D011725:Pyridines; C033472:10,10'-dimethyl-9,9'-biacridinium
keywords: Anionophore; Anionophoric activity; Benzimidazole; Ion selectivity