title: Novel bioactive substances in human colostrum: could they play a role in postnatal adaptation?
abstract: OBJECTIVE
  To determine maternal colostrum/serum concentrations of the bioactive substances irisin, adropin and copeptin and investigate their association with several perinatal parameters and pathologic conditions during pregnancy.
  
  
  METHODS
  In a cohort of 81 mothers with full-term deliveries, colostrum/serum concentrations of irisin, adropin and copeptin were prospectively evaluated by ELISA on Day 3-4 postpartum.
  
  
  RESULTS
  Copeptin and adropin were detectable in human colostrum at higher, while irisin at lower concentrations than in maternal serum (p < 0.001 in all cases). Colostrum adropin and copeptin concentrations positively correlated with maternal serum ones (r = 0.421, p < 0.001 and r = 0.304, p = 0.006, respectively).
  
  
  CONCLUSIONS
  Irisin, adropin and copeptin are present in colostrum and we speculate that they may be implicated in postnatal adaptation with respect to thermoregulation, vascular adaptation, glucose metabolism, lung function and fluid homeostasis. These findings may possibly enhance the necessity for early breastfeeding, particularly of infants born by cesarean section, who are prone to hypothermia, breathing disorders and dehydration.
authors.affiliation: a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece , and.
authors.forename: Despina D
authors.initials: DD
authors.lastname: Briana
authors.affiliation: a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece , and.
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.affiliation: a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece , and.
authors.forename: Theodora
authors.initials: T
authors.lastname: Boutsikou
authors.affiliation: b Laboratory of Clinical Biochemistry-Molecular Diagnostics , Second Department of Pediatrics, National and Kapodistrian University of Athens , Athens , Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Marmarinos
authors.affiliation: b Laboratory of Clinical Biochemistry-Molecular Diagnostics , Second Department of Pediatrics, National and Kapodistrian University of Athens , Athens , Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gourgiotis
authors.affiliation: a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece , and.
authors.forename: Ariadne
authors.initials: A
authors.lastname: Malamitsi-Puchner
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000704:Analysis of Variance; D001798:Blood Proteins / Q000032:analysis*; D015331:Cohort Studies; D003126:Colostrum / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005353:Fibronectins / Q000032:analysis* / Q000097:blood; D006020:Glycopeptides / Q000032:analysis* / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D036341:Intercellular Signaling Peptides and Proteins; D008895:Milk, Human / Q000737:chemistry*; D010455:Peptides / Q000032:analysis* / Q000097:blood; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy
chemical_list: D001798:Blood Proteins; C568440:Enho protein, human; C577593:FNDC5 protein, human; D005353:Fibronectins; D006020:Glycopeptides; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C048197:copeptins
keywords: Adropin; colostrum; copeptin; irisin; maternal serum