title: A rare case of thyroid storm.
abstract: Thyroid storm is a rare and life-threatening state of thyroid hormone excess. Rapid recognition of thyroid storm is key to decreasing the morbidity and mortality of this condition. Clinical manifestations of thyroid storm include unexplained weight loss, hyperactivity and irritability. The most common causes of thyrotoxicosis are Graves' disease, toxic multinodular goitre and toxic adenoma. We present a rare case of thyroid storm induced by dual nivolumab and ipilimumab immunotherapy in a patient receiving treatment for advanced melanoma. In this case, our patient was admitted for thyroid storm 1 month after initiating treatment with nivolumab and ipilimumab immunotherapy. The patient was treated with β-blockers, antithyroid medications and systemic steroids resulting in an improvement in thyroid function testing and symptoms.
authors.affiliation: Department of Family Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Brock
authors.initials: B
authors.lastname: McMillen
authors.affiliation: Department of Family Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Manvinder Shelley
authors.initials: MS
authors.lastname: Dhillon
authors.affiliation: Department of Family Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Yong-Yow
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000074324:Ipilimumab; D008545:Melanoma / Q000188:drug therapy*; D000077594:Nivolumab; D013958:Thyroid Crisis / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000074324:Ipilimumab; D000077594:Nivolumab