title: Twin-to-Twin Transfusion Syndrome: From Observational Evidence to Randomized Controlled Trials.
abstract: Fetoscopic surgery is widely accepted as the preferred first-line treatment for twin-twin transfusion syndrome (TTTS). Nonetheless, the broad diffusion of this technique relies on a single multicentric-randomized trial. We hereby question this trial in a post-hoc Bayesian analysis, submitting its results to several scenarios comprising the alternative published non-randomized literature and pessimistic opinions regarding this surgery. Furthermore, we also discuss further refinements in indications, questioning potential alternatives in early stages of the disease.
authors.affiliation: Department of Obstetrics and Maternal-Fetal Medicine,Hôpital Necker - Enfants Malades,AP-HP,Paris,France.
authors.forename: Julien J
authors.initials: JJ
authors.lastname: Stirnemann
authors.affiliation: Department of Obstetrics and Maternal-Fetal Medicine,Hôpital Necker - Enfants Malades,AP-HP,Paris,France.
authors.forename: Gihad
authors.initials: G
authors.lastname: Chalouhi
authors.affiliation: Department of Obstetrics and Maternal-Fetal Medicine,Hôpital Necker - Enfants Malades,AP-HP,Paris,France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
mesh_terms: D001499:Bayes Theorem; D005260:Female; D005330:Fetofetal Transfusion / Q000503:physiopathology* / Q000601:surgery; D005332:Fetoscopy; D006801:Humans; D017075:Laser Coagulation; D011247:Pregnancy; D059285:Pregnancy, Twin; D016032:Randomized Controlled Trials as Topic
keywords: TTTS; fetoscopy; laser; monochorionic; randomized controlled trial