title: Grey-Matter Metabolism in Relation with White-Matter Lesions in Older Hypertensive Patients with Subjective Memory Complaints: A Pilot Voxel-Based Analysis Study.
abstract: This study aimed at assessing the changes in brain metabolism related to white-matter magnetic resonance (MR) hyperintensities of presumed vascular origin, with a voxel-based quantitative analysis of (18F)-fluorodesoxyglucose positron emission tomography (FDG-PET) imaging.
  
  
  
  Sixty older hypertensive patients with subjective memory complaints (75 ± 5 years, 34 women) were prospectively referred to FDG-PET and MRI brain imaging. The Statistical Parametric Mapping software was used to assess the correlation between brain distribution of FDG and white-matter hyperintensities assessed by the Fazekas score on MRI images.
  
  
  
  The Fazekas score was inversely related to FDG uptake, independently of age and gender, within 14 Brodmann areas located mainly in the frontal lobe but also in certain limbic, insular and temporal areas. This relationship was also found to be largely independent of the volume of grey matter expressed in percentage of cranial volume, an index of atrophy.
  
  
  
  White-matter MR hyperintensities of presumed vascular origin are cross-sectionally associated with a lower grey-matter metabolism, mainly but not only within frontal areas and independently of age, gender and grey-matter atrophy.
authors.affiliation: Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Nancy, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Verger
authors.forename: Gabriela
authors.initials: G
authors.lastname: Hossu
authors.forename: Anna
authors.initials: A
authors.lastname: Kearney-Schwartz
authors.forename: Serge
authors.initials: S
authors.lastname: Bracard
authors.forename: Veronique
authors.initials: V
authors.lastname: Roch
authors.forename: Axel
authors.initials: A
authors.lastname: Van der Gucht
authors.forename: Renaud
authors.initials: R
authors.lastname: Fay
authors.forename: Athanase
authors.initials: A
authors.lastname: Benetos
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Marie
authors.forename: Laure
authors.initials: L
authors.lastname: Joly
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004734:Energy Metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D066128:Gray Matter / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis; D056784:Leukoencephalopathies / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012307:Risk Factors; D066127:White Matter / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18