title: Pharmacokinetics of a new ivermectin/praziquantel suspension after intramuscular administration in sheep.
abstract: A new oil suspension containing 0.10% ivermectin (IVM) and 15% praziquantel (PZQ) (Tivm+pzq) for intramuscular injection was developed for sheep, and its pharmacokinetics was investigated in sheep. The quality of the new product met the technical standards set by the Ministry of Agriculture of the People's Republic of China. In pharmacokinetics, the commercially available single-component products approved by the Chinese Ministry of Agriculture and widely used in the livestock industry in China were selected as reference products (Rivm and Rpzq). The results showed that all of the IVM pharmacokinetic parameters of Tivm+pzq were similar to those of the reference. However, after adminstration of Tivm+pzq, mean residence time (MRT) and plasma elimination half-life (t1/2z) were 20.36h and 11.65h, which were 2.61 and 3.22 times longer than those of Rpzq (7.81h and 3.62h). In summary, the MRT and t1/2z of PZQ in Tivm+pzq were prolonged and IVM pharmacokinetic parameters were similar to commercial product, therefore the new injection may be an alternative choice for sheep to control parasites sensitive to IVM and PZQ.
authors.affiliation: College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Shusheng
authors.initials: S
authors.lastname: Tang
authors.affiliation: College of Veterinary Medicine, China Agricultural University, Beijing, China; Shanghai Hanvet Bio-Pharm Co., Ltd., Shanghai, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Chen
authors.affiliation: College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Minyi
authors.initials: M
authors.lastname: Qian
authors.affiliation: China Institute of Veterinary Drug Control, Beijing, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Hao
authors.affiliation: College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: xiaoxl58@cau.163.com.
authors.forename: Xilong
authors.initials: X
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D005260:Female; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008297:Male; D011223:Praziquantel / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011897:Random Allocation; D012756:Sheep; D013535:Suspensions / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000871:Anthelmintics; D013535:Suspensions; D011223:Praziquantel; D007559:Ivermectin
keywords: Ivermectin; Pharmacokinetics; Praziquantel; Sheep; Suspension