title: Synthesis of novel anticancer ruthenium-arene pyridinylmethylene scaffolds via three-component reaction.
abstract: A novel three components approach for the synthesis of bioactive Ru-arene pyridinylmethylene complexes has been developed using pyridine carboxaldehyde, amino pyridine and dichloro (p-cymene) ruthenium(II) dimer as starting materials. These scaffolds were screened for their anticancer activity against breast cancer (MCF7) and human Epitheloid Cervix Carcinoma (HeLa) cell line. It was established that compounds [(η(6)-pcymene)RuCl(κ(2)-N,N-(3,5-dinitro-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4o), [(η(6)-pcymene)RuCl(κ(2)-N,N-N-(3,5-dibromo-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4c), [(η(6)-pcymene)RuCl(κ(2)-N,N-(3,5-dibromo-6-methylpyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4j) and [(η(6)-pcymene)RuCl(κ(2)-N,N-3(3-bromo-5-methyl-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4b) were significantly active against both the cell lines.
authors.affiliation: Department of chemistry, School of Advanced Sciences, VIT University, Vellore 632014, India.
authors.forename: Gajanan Raosaheb
authors.initials: GR
authors.lastname: Jadhav
authors.affiliation: Department of chemistry, School of Advanced Sciences, VIT University, Vellore 632014, India.
authors.forename: Sohini
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Department of chemistry, School of Advanced Sciences, VIT University, Vellore 632014, India.
authors.forename: Mohit
authors.initials: M
authors.lastname: Chhabra
authors.affiliation: Department of chemistry, School of Advanced Sciences, VIT University, Vellore 632014, India. Electronic address: priyankar.paira@vit.ac.in.
authors.forename: Priyankar
authors.initials: P
authors.lastname: Paira
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D011725:Pyridines; D012428:Ruthenium
keywords: Anticancer activity; Fluorescence profile; Ruthenium dimer; Ruthenium–arene pyridinylmethylene scaffolds; Three component reactions; Toxicity study