title: Inverted Sinonasal Papilloma Masquerading as a Malignancy - Report of an Unusual Case.
abstract: Inverted sinonasal papilloma (ISP) is a benign epithelial neoplasm arising from the Schneiderian membrane. We report a case of ISP in a 50-year-old male that clinically presented as a polypoid mass in the nasal cavity. Imaging studies revealed it to be an aggressive lesion showing intracranial extension. On histopathological examination of the excised specimen, a diagnosis of ISP was arrived at. However, an extensive sampling of the tissue revealed no evidence of any malignant transformation. Taking into account the suggested viral aetiology for such lesions and the aggressiveness observed in this case, human papillomavirus (HPV) profiling was done but it turned out to be negative. Only one other case of inverted sinonasal papilloma arising from the nasal cavity and involving the brain has been reported in the literature to date. Considering the alarming clinical course in spite of its benign nature, it is important for the pathologist and surgeon to be well informed about this lesion.
authors.affiliation: Oral and Maxillofacial Pathology and Microbiology, KSR Institute of Dental Science and Research.
authors.forename: Harikrishnan
authors.initials: H
authors.lastname: Prasad
authors.affiliation: Oral and Maxillofacial Pathology, Consultant Oral Pathologist.
authors.forename: Ranganath
authors.initials: R
authors.lastname: Sruthi
authors.affiliation: Oral and Maxillofacial Pathology, Consultant Oral Pathologist.
authors.forename: Krishnamurthy
authors.initials: K
authors.lastname: Anuthama
authors.affiliation: Oral and Maxillofacial Surgery, KSR Institute of Dental Science and Research.
authors.forename: Mahendra
authors.initials: M
authors.lastname: Perumal
authors.affiliation: Neurosurgeon, Sri Vijaya Hi-Tech Hospitals, Erode.
authors.forename: Ranganathan
authors.initials: R
authors.lastname: Parthasarathy
keywords: intracranial extension; inverted papilloma; schneiderian papilloma; sinonasal papilloma