title: Significant roles played by interleukin-10 in outcome of pregnancy.
abstract: Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10 (IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK1/STAT3 pathway in the target cells. This review has collected recent data regarding the status of IL-10 expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Mobini
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mortazavi
authors.affiliation: Yadegar Emam Health Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Nadi
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zare-Bidaki
authors.affiliation: Department of Microbiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Pourtalebi
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
keywords: IL-10; Preterm delivery; Term delivery