title: The role of innate immunity in the immunopathology and treatment of HBV infection.
abstract: In this review we give a brief update on sensors recently determined to be capable of detecting HBV, and examine how the virus represses the induction of pro-inflammatory cytokines like type I interferons. We overview cellular components of innate immunity that are present at high frequencies in the liver, and discuss their roles in HBV control and/or pathogenesis. We argue that many innate effectors have adaptive-like features or can exert specific effects on HBV through immunoregulation of T cells. Finally we consider current and possible future strategies to manipulate innate immunity as novel approaches towards a functional cure for HBV.
authors.affiliation: Division of Infection and Immunity and Institute of Immunity and Transplantation, UCL, United Kingdom. Electronic address: m.maini@ucl.ac.uk.
authors.forename: Mala K
authors.initials: MK
authors.lastname: Maini
authors.affiliation: Molecular Microbiology and Immunology Department, Saint Louis University School of Medicine, United States.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Gehring
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use / Q000633:toxicity*; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000473:pathology / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D007113:Immunity, Innate; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000998:Antiviral Agents; D006510:Hepatitis B Antibodies
keywords: HBV innate immunity; Innate immunotherapy; Innate sensors; Interferon-alpha; MAITs; MDSC; Monocytes; NK cells