title: Severe transaminitis in a paediatric patient with systemic lupus erythaematosus and a discussion of the literature.
abstract: A 15-year-old African-American girl with known systemic lupus erythaematosus (SLE) presented to the emergency room with fever, abdominal distension, pain and vomiting. She was found to have severe transaminitis on laboratory examination, which prompted further work up including imaging and liver biopsy. Although complete diagnostic criteria were not met, histology was suggestive of autoimmune hepatitis (AIH). She was treated with steroids and azathioprine with good response and resolution of liver function tests. Availability of the literature discussing patients of any age with SLE and AIH is minimal, and consists mostly of small case series and some case reports. The juvenile literature on SLE and AIH occurring in the same patient is even scarcer and should be further studied at a multicentre level.
authors.affiliation: Baystate Medical Center Children's Hospital, Springfield, Massachusetts, USA.
authors.forename: Garima
authors.initials: G
authors.lastname: Sarda
authors.affiliation: Baystate Medical Center Children's Hospital, Springfield, Massachusetts, USA.
authors.forename: Rohini
authors.initials: R
authors.lastname: Harvey
mesh_terms: D000293:Adolescent; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D013256:Steroids / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D001379:Azathioprine