title: Scaffolds of Hyaluronic Acid-Poly(Ethyl Acrylate) Interpenetrating Networks: Characterization and In Vitro Studies.
abstract: Hyaluronic acid (HA) provides many advantages to regenerative implants through its bioactive properties, but it also has many limitations as a biomaterial if it is not chemically modified. In order to overcome some of these limitations, HA has been combined with poly(ethyl acrylate) in the form of interpenetrating polymeric networks (IPNs), in which the HA network is crosslinked with divinyl sulfone. Scaffolds of this IPN have been produced through a template-leaching methodology, and their properties have been compared with those of single-network scaffolds made of either PEA or crosslinked HA. A fibroblast cell line has been used to assess the in vitro performance of the scaffolds, revealing good cell response and a differentiated behavior on the IPN surface when compared to the individual polymers. Altogether, the results confirm that this type of material offers an interesting microenvironment for cells, which can be further improved toward its potential use in medical implants.
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Pérez
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lloret Compañ
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022, Valencia, Spain.|Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Monleón Pradas
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022, Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Martínez-Ramos
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D006820:Hyaluronic Acid / Q000737:chemistry*; D051379:Mice; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D013052:Spectrometry, X-Ray Emission; D013314:Stress, Mechanical; D013718:Tensile Strength; D013818:Thermogravimetry; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; C478961:poly(ethylacrylate); D006820:Hyaluronic Acid
keywords: biomaterials; hyaluronic acid; interpenetrating networks (IPN); poly(ethyl acrylate); scaffolds