title: Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis.
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany. martin.hasselblatt@ukmuenster.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Hasselblatt
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Thomas
authors.affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.|German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Hovestadt
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.|Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Schrimpf
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.|Department of Pediatric Oncology and Hematology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Pascal
authors.initials: P
authors.lastname: Johann
authors.affiliation: Institute of Human Genetics, Christian-Albrechts-University Kiel, Kiel, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Bens
authors.affiliation: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Oyen
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Peetz-Dienhart
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Crede
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.|Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Wefers
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
authors.forename: Hannes
authors.initials: H
authors.lastname: Vogel
authors.affiliation: Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany.
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Riemenschneider
authors.affiliation: Department of Radiology, Oncology and Anatomic-Pathology Sciences, Sapienza University, Rome, Italy.|IRCCS Neuromed, Pozzilli, IS, Italy.
authors.forename: Manila
authors.initials: M
authors.lastname: Antonelli
authors.affiliation: Department of Radiology, Oncology and Anatomic-Pathology Sciences, Sapienza University, Rome, Italy.|IRCCS Neuromed, Pozzilli, IS, Italy.
authors.forename: Felice
authors.initials: F
authors.lastname: Giangaspero
authors.affiliation: Institute of Pathology, St. Luke's Medical Center, Quezon City, Philippines.
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Bernardo
authors.affiliation: Department of Pathology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Caterina
authors.initials: C
authors.lastname: Giannini
authors.affiliation: Section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Nasir
authors.initials: N
authors.lastname: Ud Din
authors.affiliation: Division of Neuropathology, UCSF Medical Center, San Francisco, CA, USA.
authors.forename: Arie
authors.initials: A
authors.lastname: Perry
authors.affiliation: Faculty of Medicine, Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany.
authors.forename: Kathy
authors.initials: K
authors.lastname: Keyvani
authors.affiliation: Division of Anatomical Pathology, Neuropathology Specialty Group, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
authors.forename: Frank
authors.initials: F
authors.lastname: van Landeghem
authors.affiliation: Department of Pediatric Hematology and Oncology, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Sumerauer
authors.affiliation: 2nd Department of Pediatrics, Semmelweis University, 1094, Budapest, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Hauser
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.|Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Capper
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.|Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Andrey
authors.initials: A
authors.lastname: Korshunov
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: David T W
authors.initials: DT
authors.lastname: Jones
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.|Department of Pediatric Oncology and Hematology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Pfister
authors.affiliation: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schneppenheim
authors.affiliation: Institute of Human Genetics, Christian-Albrechts-University Kiel, Kiel, Germany.
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.affiliation: Swabian Childrens' Cancer Center, Childrens' Hospital Augsburg and EU-RHAB Registry, Augsburg, Germany.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Frühwald
authors.affiliation: German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.|Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Kool
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002817:Chordoma / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016000:Cluster Analysis; D056915:DNA Copy Number Variations; D019175:DNA Methylation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D018335:Rhabdoid Tumor / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000071796:SMARCB1 Protein / Q000172:deficiency* / Q000235:genetics; D016019:Survival Analysis; D013724:Teratoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human