title: [Therapeutic effects of porcine versus rabbit antithymocyte globulins for treatment of severe aplastic anemia].
abstract: OBJECTIVE
  To compare the efficacy of porcine and rabbit antithymocyte globulins (ATG) in the treatment of severe aplastic anemia (SAA).
  
  
  METHODS
  We reviewed the clinical data of 43 SAA patients receiving porcine ALG treatment and 32 patients receiving rabbit ATG treatment between 2004 and 2013 in our hospital. The overall response rates of the patients at 6 month were compared, and the patients' survival in the two groups was analyzed using Kaplan-Meier survival curves.
  
  
  RESULTS
  The overall response rates at 6 months was significantly higher in porcine ALG group than in rabbit ATG group (79.07% vs 56.25%, P=0.034). The 5-year overall survival was also higher in porcine ALG group than in rabbit ATG group, but this difference was not statistically significant (86.047% vs 72.878%, P=0.190).
  
  
  CONCLUSIONS
  Porcine ALG is superior over rabbit ATG in terms of hematological response but is comparable with rabbit ATG in view of the patients' survival and safety.
authors.affiliation: Department of Hematology, Second Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an 710004, China.E-mail: Shmily1989-2008@163.com.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Ma
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Cao
authors.forename: Yin-Xia
authors.initials: YX
authors.lastname: Chen
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Wan-Hong
authors.initials: WH
authors.lastname: Zhao
authors.forename: Wang-Gang
authors.initials: WG
authors.lastname: Zhang
mesh_terms: D000741:Anemia, Aplastic / Q000628:therapy*; D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D006801:Humans; D053208:Kaplan-Meier Estimate; D011817:Rabbits; D012189:Retrospective Studies; D013552:Swine
chemical_list: D000961:Antilymphocyte Serum