title: Effect of organo and inorganic lithium salt on human blood plasma glutathione- A comparative study.
abstract: Investigation of toxicological effect of various metals is the field of interest for toxicological scientists since four to five decades and especially the toxicological effect of those drugs containing metals and there use is common because there is no other choice except to use these metal containing drugs. Inorganic as well as organic salts of lithium are commonly used in prophylaxis and treatments of many psychiatric disorders. The aim of the present study was to see the difference between the effect of organic and inorganic salt of lithium commonly used in psychiatric disorders on the GSH of human blood plasma. It is the scientific fact that ionic dissociation of organic and inorganic salts of any metal is always quite different hence to prove this fact, the effect of lithium citrate (organic salt of lithium) and lithium carbonate (inorganic salt of lithium) was investigated on human blood plasma GSH to find the difference between the effect of two. Ellman's method was used for the quantification of glutathione contents in plasma. It was found that lithium citrate decrease plasma GSH contents less than lithium carbonate indicating that organic salts of lithium are safe than inorganic salts of lithium when are used in psychiatric disorders. Further to analyze the effect of organic and inorganic salt of lithium on blood plasma GSH with the increase in incubation time was also evaluated and was found that both concentration and time dependent effect of organic salt of lithium shows that this salt has decreased plasma GSH contents of human blood less than inorganic salt of lithium either by promoting oxidation of GSH into GSSG or by lithium glutathione complex formation. These results suggest the physicians that the use of organic lithium salts is much safer than inorganic salts of lithium in terms of depletion of blood plasma GSH contents.
authors.forename: Hashmat
authors.initials: H
authors.lastname: Ullah
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, KPK, Pakistan.
authors.forename: Muhammad Farid
authors.initials: MF
authors.lastname: Khan
authors.affiliation: Faculty of Pharmacy, University of Balochistan, Quetta, Pakistan.
authors.forename: Syed Umer
authors.initials: SU
authors.lastname: Jan
authors.affiliation: Department of Chemistry, Gomal University, Dera Ismail Khan, KPK, Pakistan.
authors.forename: Farwa
authors.initials: F
authors.lastname: Hashmat
mesh_terms: D015415:Biomarkers / Q000097:blood; D002951:Citrates / Q000097:blood* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000097:blood*; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D016651:Lithium Carbonate / Q000097:blood* / Q000633:toxicity; D011619:Psychotropic Drugs / Q000097:blood* / Q000633:toxicity; D018570:Risk Assessment; D013997:Time Factors
chemical_list: D015415:Biomarkers; D002951:Citrates; D011619:Psychotropic Drugs; D016651:Lithium Carbonate; C070669:lithium citrate; D005978:Glutathione; D019803:Glutathione Disulfide