title: Postprandial Reactive Hypoglycemia Treated with a Low-dose Alpha-glucosidase Inhibitor: Voglibose May Suppress Oxidative Stress and Prevent Endothelial Dysfunction.
abstract: We encountered a 62-year-old woman who experienced frequent episodes of hypoglycemia. She was diagnosed with postprandial reactive hypoglycemia according to the results of oral glucose and sucrose tolerance tests, having undergone an endocrinological examination and image inspection. The administration of low-dose voglibose, an alpha-glucosidase inhibitor (α-GI), improved the glucose fluctuations and inhibited hypoglycemic symptoms. Voglibose is also known to diminish oxidative stress and maintain endothelial function after hyperglycemia. An α-GI might effectively prevent hypoglycemic symptoms and endothelial dysfunction by suppressing oxidative stress in such cases.
authors.affiliation: Department of Endocrinology and Metabolism, Dokkyo Medical University, Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Katsura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sagara
authors.forename: Chie
authors.initials: C
authors.lastname: Aoki
authors.forename: Mai
authors.initials: M
authors.lastname: Nishida
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Aso
mesh_terms: D005260:Female; D065089:Glycoside Hydrolase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007003:Hypoglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007294:Inositol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007294:Inositol; C102817:voglibose