title: Clinical Outcomes in Patients with Recurrent or Metastatic Human Papilloma Virus-positive Head and Neck Cancer.
abstract: BACKGROUND
  There are few data regarding the role of human papilloma virus (HPV) in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).
  
  
  METHODS
  A retrospective chart review was carried out using our electronic medical record (EPIC) for all patients diagnosed with HPV-positive R/M HNSCC between 2010 and 2014 with minimum of 6 months of follow-up in order to assess progression-free survival (PFS) and overall survival (OS).
  
  
  RESULTS
  We assessed 11 patients who underwent a variety of treatments. PFS and OS were 7 and 34+ months, respectively. Four patients (36%) were still alive and disease-free (median OS of 39+ months). Three disease-free patients had been treated with taxane, platinum and 5-fluorouracil as aggressive curative systemic therapy. Another patient treated with TPF was disease-free for 25 months and died of disease at 42 months.
  
  
  CONCLUSIONS
  Our study demonstrates favorable prognosis for patients with HPV-positive R/M HNSCC and that aggressive systemic treatment can lead to a prolonged disease-free period or possibly cure, even after metastasis.
authors.affiliation: Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A. Rajan.dang@icahn.mssm.edu.
authors.forename: Rajan P
authors.initials: RP
authors.lastname: Dang
authors.affiliation: Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Valerie H
authors.initials: VH
authors.lastname: LE
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Brett A
authors.initials: BA
authors.lastname: Miles
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Marita S
authors.initials: MS
authors.lastname: Teng
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Genden
authors.affiliation: Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Bakst
authors.affiliation: Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Vishal
authors.initials: V
authors.lastname: Gupta
authors.affiliation: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: David Y
authors.initials: DY
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Demicco
authors.affiliation: Department of Hematology-Oncology-Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Marshall R
authors.initials: MR
authors.lastname: Posner
authors.affiliation: Department of Hematology-Oncology-Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
authors.forename: Krzysztof J
authors.initials: KJ
authors.lastname: Misiukiewicz
mesh_terms: D001952:Bridged-Ring Compounds / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D018572:Disease-Free Survival; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000821:virology; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D030361:Papillomavirus Infections / Q000188:drug therapy; D011379:Prognosis; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D001952:Bridged-Ring Compounds; D009944:Organoplatinum Compounds; D043823:Taxoids; C080625:taxane; D005472:Fluorouracil
keywords: HPV; Human papillomavirus; metastatic; oropharyngeal cancer; recurrent