title: Cerebellum Development and Tumorigenesis: A p53-Centric Perspective.
abstract: The p53 protein has been extensively studied for its role in suppressing tumorigenesis, in part through surveillance and maintenance of genomic stability. p53 has been associated with the induction of a variety of cellular outcomes including cell cycle arrest, senescence, and apoptosis. This occurs primarily, but not exclusively, through transcriptional activation of specific target genes. By contrast, the participation of p53 in normal developmental processes has been largely understudied. This review focuses on possible functions of p53 in cerebellar development. It can be argued that a better understanding of such mechanisms will provide needed insight into the genesis of certain embryonic cancers including medulloblastomas, and thus lead to more effective therapies.
authors.affiliation: Department of Oncological Sciences and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Barthelery
authors.affiliation: Department of Oncological Sciences and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. Electronic address: james.manfredi@mssm.edu.
authors.forename: James J
authors.initials: JJ
authors.lastname: Manfredi
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D002531:Cerebellum / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D004195:Disease Models, Animal; D047108:Embryonic Development; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000502:physiology*
chemical_list: D053823:Hedgehog Proteins; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53
keywords: Sonic Hedgehog pathway; cerebellum development; medulloblastomas; p53