title: Hydrazide-hydrazones of 3-methoxybenzoic acid and 4-tert-butylbenzoic acid with promising antibacterial activity against Bacillus spp.
abstract: A series of 28 hydrazide-hydrazones of 3-methoxybenzoic and 4-tert-butylbenzoic acid were synthesized and screened in vitro against the panel of reference strains of bacteria and fungi with the use of the broth microdilution method according to EUCAST and CLSI guidelines. Five of the synthesized compounds were found to exhibit high bacteriostatic or bactericidal activity against Gram-positive bacteria. The antimicrobial activity of compounds 13, 14, and 16 against Bacillus spp. was higher than that of commonly used antibiotics, like cefuroxime or ampicillin.
authors.affiliation: a Department of Organic Chemistry and.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Popiołek
authors.affiliation: b Department of Pharmaceutical Microbiology , Faculty of Pharmacy, Medical University of Lublin , Lublin , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Biernasiuk
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects*; D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology*; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001565:Benzoates; D006834:Hydrazines; D006835:Hydrazones; C034290:4-tert-butylbenzoic acid; C056267:3-methoxybenzoic acid; D014641:Vanillic Acid
keywords: Antimicrobial activity; Bacillus spp.; MBC; MIC; hydrazide-hydrazones