title: Physico-chemical properties of alginate/shellac aqueous-core capsules: Influence of membrane architecture on riboflavin release.
abstract: To enhance physico-chemical properties of alginate liquid-core capsules, shellac was incorporated into the membrane (composite capsules) or as an additional external layer (coated capsules). The influence of pH, coating time, shellac concentration and preparation mechanism (acid or calcium precipitation) were investigated. Results showed that shellac significantly influenced the capsules properties. The feasibility of shellac incorporation was closely related to the preparation conditions as confirmed by Infrared spectroscopy. Optical, fluorescence and scanning electron microscopy, highlighted different capsules and membranes architectures. In contrast to simple and composite capsules, coated capsules showed a pH-dependent release of the entrapped vitamin especially after shellac crosslinking with calcium. Heating of coated capsules above the glass transition temperature investigated by Differential Scanning Calorimetry, led to irreversible structural change due to thermoplastic behavior of shellac and enhanced riboflavin retention under acidic conditions. This global approach is useful to control release mechanism of low molecular weight molecules from macro and micro-capsules.
authors.affiliation: Laboratoire d'ingénierie des biomolécules (LIBio), ENSAIA-Université de Lorraine, 2 avenue de la forêt de Haye, TSA 40602, 54518 Vandœuvre-lès-Nancy Cedex, France. Electronic address: ghazi.ben-messaoud@univ-lorraine.fr.
authors.forename: Ghazi
authors.initials: G
authors.lastname: Ben Messaoud
authors.affiliation: Laboratoire d'ingénierie des biomolécules (LIBio), ENSAIA-Université de Lorraine, 2 avenue de la forêt de Haye, TSA 40602, 54518 Vandœuvre-lès-Nancy Cedex, France. Electronic address: laura.sanchez-gonzalez@univ-lorraine.fr.
authors.forename: Laura
authors.initials: L
authors.lastname: Sánchez-González
authors.affiliation: Cookal company, 21 avenue de la Meurthe, 54320 Maxéville, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Probst
authors.affiliation: Laboratoire d'ingénierie des biomolécules (LIBio), ENSAIA-Université de Lorraine, 2 avenue de la forêt de Haye, TSA 40602, 54518 Vandœuvre-lès-Nancy Cedex, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Jeandel
authors.affiliation: Laboratoire d'ingénierie des biomolécules (LIBio), ENSAIA-Université de Lorraine, 2 avenue de la forêt de Haye, TSA 40602, 54518 Vandœuvre-lès-Nancy Cedex, France.
authors.forename: Elmira
authors.initials: E
authors.lastname: Arab-Tehrany
authors.affiliation: Laboratoire d'ingénierie des biomolécules (LIBio), ENSAIA-Université de Lorraine, 2 avenue de la forêt de Haye, TSA 40602, 54518 Vandœuvre-lès-Nancy Cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Desobry
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002214:Capsules; D055598:Chemical Phenomena; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005240:Feasibility Studies; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008567:Membranes, Artificial; D012116:Resins, Plant / Q000737:chemistry*; D012256:Riboflavin / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000464:Alginates; D002214:Capsules; D004337:Drug Carriers; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D012116:Resins, Plant; D014867:Water; C003934:shellac; D020723:Glucuronic Acid; D012256:Riboflavin
keywords: Alginate; Capsules; Riboflavin; Shellac; pH-dependent release