title: Serum Levels of TNF-α and IL-6 Are Associated With Pregnancy-Induced Hypertension.
abstract: Tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) are proinflammatory cytokines and known to be involved in many pathological processes. However, the association between serum levels of TNF-α, IL-6, and pregnancy-induced hypertension (PIH) is unclear. The aim of the present study was to determine the serum levels of TNF-α and IL-6 and to investigate their potential correlation with PIH. In this study, the serum concentrations of TNF-α and IL-6 in pregnant women who developed PIH and normal pregnant women were measured. We found that the serum concentrations of TNF-α and IL-6 were significantly increased in the patients with PIH compared to the normal pregnant women. In addition, elevated TNF-α and IL-6 concentrations were associated with pathological complications. Moreover, in a hypoxia-induced PIH mice model, animals from the PIH group demonstrated higher TNF-α and IL-6 levels when compared to control, and serum TNF-α and IL-6 levels were positively correlated with right ventricular systolic blood pressure. Furthermore, TNF-α and IL-6 levels were decreased when the PIH mice were treated with remodulin compared to control group. In conclusion, our results suggested that high serum TNF-α and IL-6 levels are associated with PIH, and TNF-α and IL-6 might be potential predictors in the prognosis of PIH.
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China Zibo Central Hospital, Zibo, Shandong, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Zibo Central Hospital, Zibo, Shandong, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ding
authors.affiliation: Zibo Central Hospital, Zibo, Shandong, China.
authors.forename: Bide
authors.initials: B
authors.lastname: Duan
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China xietongwangg@sina.com.
authors.forename: Xietong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D000860:Hypoxia / Q000150:complications; D015850:Interleukin-6 / Q000097:blood*; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: IL-6; pregnancy-induced hypertension; serum; tumor necrosis factor α