title: Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus.
abstract: We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus. The alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. The trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus.
authors.forename: Gary
authors.initials: G
authors.lastname: Crameri
authors.forename: Peter A
authors.initials: PA
authors.lastname: Durr
authors.forename: Reuben
authors.initials: R
authors.lastname: Klein
authors.forename: Adam
authors.initials: A
authors.lastname: Foord
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.forename: Sarah
authors.initials: S
authors.lastname: Riddell
authors.forename: Jessica
authors.initials: J
authors.lastname: Haining
authors.forename: Dayna
authors.initials: D
authors.lastname: Johnson
authors.forename: Maged G
authors.initials: MG
authors.lastname: Hemida
authors.forename: Jennifer
authors.initials: J
authors.lastname: Barr
authors.forename: Malik
authors.initials: M
authors.lastname: Peiris
authors.forename: Deborah
authors.initials: D
authors.lastname: Middleton
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002161:Camelids, New World / Q000276:immunology* / Q000821:virology*; D018352:Coronavirus Infections / Q000276:immunology* / Q000821:virology*; D004195:Disease Models, Animal; D005260:Female; D065207:Middle East Respiratory Syndrome Coronavirus / Q000276:immunology*; D009500:Neutralization Tests; D019562:Viral Load; D017201:Virus Shedding
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: MERS-CoV; Middle East respiratory syndrome; SARS; alpaca; camel; coronavirus; experimental animal model; infection; rechallenge; severe acute respiratory syndrome; shedding; vaccine; viruses; zoonoses