title: Laparoscopic Splenectomy and Esophagogastric Devascularization for Liver Cirrhosis and Portal Hypertension Is a Safe, Effective, and Minimally Invasive Operation.
abstract: BACKGROUND
  In the recent years, laparoscopic splenectomy and esophagogastric devascularization (LSD) for liver cirrhosis and portal hypertension rapidly gained the interest of hepatobiliary surgeons due to its minimal invasion. This study aimed to gather and analyze available data from the observational studies that have compared LSD and open splenectomy and esophagogastric devascularization (OSD) for liver cirrhosis and portal hypertension.
  
  
  METHODS
  All the studies comparing LSD and OSD for liver cirrhosis and portal hypertension were searched on the available databases, including the Cochrane Central Register of Controlled Trials, Medline, Science Citation Index, EMBASE, China National Knowledge Infrastructure, Wanfang Database, and China Biomedical Database. Data were analyzed using Review Manager software version 5.0.
  
  
  RESULTS
  After the literature search, a total of 17 studies were included in the meta-analysis, which involved 1093 patients: 552 in the laparoscopic group and 541 in the open group. The laparoscopic group was shown to have a lower overall postoperative complication rate (0.43; 95% confidence interval [CI; 0.29-0.64]) than the open group (P < .0001), which was not associated with heterogeneity between the studies. The laparoscopic group was shown to have a lower intraoperative blood loss (-320.62; 95% CI [-552.35 to -88.9]), shorter time of oral intake (-29.08 hours; 95% CI [-35.28 to -22.88]), and shorter hospital stay (95% CI [-6.19 to -2.19]) than those of the open group (P < .00001). The operative time of the laparoscopic group was 42.16 minutes longer (95% CI [32.20-52.11]) compared with the open group (P < .00001). There was no significant difference of hospitalization costs between the studies.
  
  
  CONCLUSIONS
  This meta-analysis demonstrated that laparoscopic left lateral resection is a safe and feasible option associated with a reduced overall complication rate. The current evidence suggested that it could be performed routinely in liver centers.
authors.affiliation: 1 Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , Zhengzhou, China .|2 People's Hospital of Zhengzhou University , Zhengzhou, China .
authors.forename: Haibo
authors.initials: H
authors.lastname: Yu
authors.affiliation: 2 People's Hospital of Zhengzhou University , Zhengzhou, China .|3 Clinical Laboratory, Henan Provincial People's Hospital , Zhengzhou, China .
authors.forename: Si
authors.initials: S
authors.lastname: Guo
authors.affiliation: 1 Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , Zhengzhou, China .|2 People's Hospital of Zhengzhou University , Zhengzhou, China .
authors.forename: Liancai
authors.initials: L
authors.lastname: Wang
authors.affiliation: 1 Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , Zhengzhou, China .|2 People's Hospital of Zhengzhou University , Zhengzhou, China .
authors.forename: Yadong
authors.initials: Y
authors.lastname: Dong
authors.affiliation: 1 Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , Zhengzhou, China .|2 People's Hospital of Zhengzhou University , Zhengzhou, China .
authors.forename: Guanjin
authors.initials: G
authors.lastname: Tian
authors.affiliation: 1 Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , Zhengzhou, China .|2 People's Hospital of Zhengzhou University , Zhengzhou, China .
authors.forename: Senmao
authors.initials: S
authors.lastname: Mu
authors.affiliation: 2 People's Hospital of Zhengzhou University , Zhengzhou, China .|4 Intensive Care and Treatment Unit, Henan Provincial People's Hospital , Zhengzhou, China .
authors.forename: Huifeng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: 1 Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , Zhengzhou, China .|2 People's Hospital of Zhengzhou University , Zhengzhou, China .
authors.forename: Deyu
authors.initials: D
authors.lastname: Li
authors.affiliation: 5 Key Laboratory of Environment and Genes Related to Diseases, Education Ministry, Xi'an Jiaotong University School of Medicine , Shaanxi, China .
authors.forename: Sihai
authors.initials: S
authors.lastname: Zhao
mesh_terms: D016063:Blood Loss, Surgical; D002681:China; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000601:surgery*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000601:surgery*; D010535:Laparoscopy; D007902:Length of Stay; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery*; D019060:Minimally Invasive Surgical Procedures; D061646:Operative Time; D011183:Postoperative Complications; D013156:Splenectomy; D014656:Vascular Surgical Procedures