title: Pemphigus in North-Western Yemen: A therapeutic study of 75 cases.
abstract: BACKGROUND
  The incidence of pemphigus, though not documented, seems to be quite high in Yemen. There is no universal consensus on the treatment of this disease.
  
  
  OBJECTIVE
  The aim was to evaluate the efficacy and side effects of different therapeutic regimens used in patients of pemphigus in North-Western Yemen.
  
  
  METHODS
  Seventy-five Yemeni patients (39 males and 36 females) were included. Diagnosis was based on clinical features, histopathology and the Tzanck test. Results of treatment with these different therapeutic regimens were compared: (1) dexamethasone-cyclophosphamide pulse (DCP), (2) dexamethasone pulse with oral azathioprine, (3) oral prednisolone with azathioprine, (4) oral prednisolone with oral cyclophosphamide, and (5) prednisolone monotherapy.
  
  
  RESULTS
  Pemphigus vulgaris (PV) was diagnosed in 46 patients, pemphigus foliaceus (PF) in 23, pemphigus vegetans (PVEG) in 5 and pemphigus herpetiformis (PH) in one. Among the 16 patients who received regular DCP therapy, 13 were in remission for 6 months to 11 years without medications (phase 4). Remission without pharmacotherapy could not be achieved with the other regimens and steroid-induced side-effects appeared to be more than with DCP.
  
  
  CONCLUSIONS
  Immunofluorescence was not available to confirm the diagnosis of pemphigus. Randomization was not done.
  
  
  CONCLUSIONS
  The DCP regimen seemed to be superior to the other regimens used.
authors.affiliation: Department of Dermatology, Saudi Hospital, Hajjah, Republic of Yemen.
authors.forename: Mishri Lal
authors.initials: ML
authors.lastname: Khatri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D011446:Prospective Studies; D020551:Pulse Therapy, Drug / Q000379:methods; D016896:Treatment Outcome; D015006:Yemen; D055815:Young Adult
chemical_list: D003907:Dexamethasone; D003520:Cyclophosphamide