title: Moieties in antidiabetic drugs as a target of insulin receptors in association with common neurological disorders.
abstract: Insulin is a peptide that can be harmful with regards to neuroplasticity, neuroprotection and neuromodulation. Furthermore, the role of insulin highlights its relevance in the progress of diverse clinical disorders as well as in the mechanisms associated with certain pathogenesis and their evolution towards diabetes, obesity and neurodegenerative diseases. The precise molecular mechanisms by which these diseases are induced remain to be elucidated. The benefits in knowing/discovering these mechanisms in animal models and humans cannot be undermined. An in depth understanding of the principal risk factors leading to obesity and their management is vital in the implementation of early-life strategies of intervention and prevention, with a view to avoid adverse late-life outcomes. Therefore, the aim of the present study was to review their possible association with antidiabetic drugs.
authors.affiliation: Laboratory of Neurochemistry, National Institute of Pediatrics, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, CP 04530, Mexico.
authors.forename: David Calderón
authors.initials: DC
authors.lastname: Guzmán
authors.affiliation: Laboratory of Pharmacology, National Institute of Pediatrics, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, CP 04530, Mexico.
authors.forename: Hugo Juárez
authors.initials: HJ
authors.lastname: Olguín
authors.affiliation: Laboratory of Pharmacology, National Institute of Pediatrics, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, CP 04530, Mexico.
authors.forename: Ernestina Hernández
authors.initials: EH
authors.lastname: García
authors.affiliation: Laboratory of Experimental Bacteriology, National Institute of Pediatrics, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, CP 04530, Mexico.
authors.forename: Maribel Ortiz
authors.initials: MO
authors.lastname: Herrera
authors.affiliation: Laboratory of Neurochemistry, National Institute of Pediatrics, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, CP 04530, Mexico.
authors.forename: Norma Osnaya
authors.initials: NO
authors.lastname: Brizuela
keywords: antidiabetic drugs; central nervous system; insulin; neurodegenerative disorders; obesity