title: Metabolically healthy obesity also has risk for hyperuricemia among Chinese general population: A cross-sectional study.
abstract: The metabolically healthy obese (MHO) refers to obese individuals with a favorable metabolic profile. It is unknown whether metabolically healthy status in persons with obesity or overweight decreases the risk of hyperuricemia. This study aims to explore the association of MHO with risk of hyperuricemia.
  
  
  
  We performed a cross-sectional study including 11,435 (5300 men and 6135 women) general population aged ≥35 years in Liaoning Province. Anthropometric measurements, laboratory examinations and self-reported information on lifestyle factors were collected by trained personnel. Metabolically healthy overweight/obesity was defined according to body mass index and ATP-III criterion of metabolically healthy status. Hyperuricemia was defined as SUA ≥7mg/dl (420mmol/L) in men or ≥6mg/dl (360mmol/L) in women. Logistic regression analyses were performed to explore the association between overweight/obesity with different metabolic status and risk of hyperuricemia.
  
  
  
  Among total subjects, 470 (4.2%) were metabolically healthy obese (MHO) and 1567 (14.0%) were metabolically unhealthy obese (MUO). For metabolically healthy female participants, the prevalence of hyperuricemia with overweight was similar to with a normal BMI (2.5% vs. 3.1%, P=0.314). Multivariate logistic regression analyses showed that MHO (OR=2.48, 95% CI: 1.81-3.41) and MUO (OR=4.81, 95% CI: 3.97-5.83) were significantly associated with hyperuricemia. However, the odds ratio in females with metabolically healthy overweight was 0.85 (95% CI: 0.53-1.37).
  
  
  
  Metabolically healthy might decline the risk of hyperuricemia, but overweight and obesity with metabolically healthy had also strong associations with hyperuricemia, except in females with metabolically healthy overweight.
authors.affiliation: Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.
authors.forename: Yintao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.
authors.forename: Naijin
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.
authors.forename: Guozhe
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China. Electronic address: yxsun@mail.cmu.edu.cn.
authors.forename: Yingxian
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity; D000067329:Obesity, Metabolically Benign / Q000097:blood / Q000150:complications*; D016017:Odds Ratio; D050177:Overweight; D015995:Prevalence; D012306:Risk; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Cardiovascular disease; Hyperuricemia; Metabolically healthy obesity