title: Consequences of lead exposure, and it's emerging role as an epigenetic modifier in the aging brain.
abstract: Lead exposure has primarily been a concern during development in young children and little attention has been paid to exposure outcomes as these children age, or even to exposures in adulthood. Childhood exposures have long term consequences, and adults who have been exposed to lead as children show a host of cognitive deficits. Lead has also been shown to induce latent changes in the aging brain, and has been implicated in the pathogenesis of neurodegenerative diseases, particularly Alzheimer's Disease, and Parkinson's. Recent research has shown that lead has the ability to alter DNA methylation, histone modifications, and miRNA expression in experimental models, and in humans. These findings implicate epigenetics in lead induced toxicity, and long term changes in individuals. Epigenetic modification could potentially provide us a mechanism by which the environment, and toxic exposures contribute to the increased susceptibility of adult neurodegenerative disease.
authors.affiliation: Neurodegeneration and Epigenomics Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, United States; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, United States.
authors.forename: Aseel
authors.initials: A
authors.lastname: Eid
authors.affiliation: Neurodegeneration and Epigenomics Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, United States; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, United States. Electronic address: nzawia@uri.edu.
authors.forename: Nasser
authors.initials: N
authors.lastname: Zawia
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D019175:DNA Methylation / Q000187:drug effects; D044127:Epigenesis, Genetic / Q000187:drug effects*; D006801:Humans; D007854:Lead / Q000009:adverse effects*; D019636:Neurodegenerative Diseases / Q000139:chemically induced
chemical_list: D007854:Lead
keywords: Aging; DNA methylation; Epigenetics; Histones; Lead; Neurodegeneration; miRNA