title: Polymeric networks for controlled release of drugs: a patent review.
abstract: BACKGROUND
  Polymeric networks for controlled drug delivery possess wide pharmaceutical and biomedical applications.
  
  
  METHODS
  In this review, we explore the diversity of polymeric networks that exist, from simple to highly complex and 'smart' embodiments. The patented delivery systems reviewed reflect this, based on both conventional polymeric networks and stimulus-responsive networks where engineering of a controlled molecular architecture of polymeric networks enables a defined response to external or internal stimuli. Future trends in terms of nano-sized polymeric network patents are also highlighted.
  
  
  CONCLUSIONS
  A critical analysis of challenges potentially facing extended propulsion of the research and development of polymeric networks is provided. The significant therapeutic potential of polymer networks for controlled drug delivery is highlighted in the patented drug delivery systems examined; however, there needs to be enhanced representation of such systems in the market and thus available to patients. Concerted efforts are therefore necessary to propel these systems from the experimental setting to pilot scale production, and preclinical and clinical testing, for extension of their practicality.
authors.affiliation: a Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa.
authors.forename: Lisa C
authors.initials: LC
authors.lastname: du Toit
authors.affiliation: a Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa.
authors.forename: Yahya E
authors.initials: YE
authors.lastname: Choonara
authors.affiliation: a Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
authors.affiliation: a Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa.
authors.forename: Viness
authors.initials: V
authors.lastname: Pillay
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D053758:Nanoparticles; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011108:Polymers / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: Controlled drug delivery; crosslinking; drug delivery systems; hydrogels; interpenetrating polymer networks; patents; polymer network; stimulus-responsive drug delivery systems