title: Endoscopic balloon dilatation of Crohn's strictures: a safe method to defer surgery in selective cases.
abstract: BACKGROUND
  Endoscopic balloon dilatation (EBD) provides a valuable alternative to surgery for strictures in Crohn's disease (CD). Data are lacking regarding the factors that improve the safety and effectiveness of EBD in CD. The aim of this study is to determine the safety and efficacy of EBD and the clinical variables, which are predictive of successful treatment of CD strictures with EBD.
  
  
  METHODS
  The records of all patients with CD in whom EBD was attempted between 2008 and 2013 were reviewed. Procedures were conducted at a single tertiary referral centre using a Boston Scientific CRE® TTS balloon. Technical success was defined as the ability to traverse the stricture with the endoscope and clinical success as the resolution of obstructive symptoms at review.
  
  
  RESULTS
  Forty-seven patients with a total of 58 strictures (19 primary and 39 anastomotic strictures) were treated with EBD with median follow-up of 37 months. A total of 161 dilatation procedures were performed, with technical success reported in 139/158 (88%) cases and clinical success reported in 105/137 (76.7%) cases with complete data. Complications occurred in 7/161 dilatations (4.3% dilatations, 15% patients), three patients with perforation, one with acute bleeding and three admitted with abdominal pain. Eighteen of the 47 patients required surgery (38%). Strictures of <50 mm (P = 0.04) and those dilated to a diameter of ≥15 mm (P = 0.031) were less likely to require surgical resection.
  
  
  CONCLUSIONS
  EBD is safe for both primary and post-surgical strictures. Stricture length and diameter of dilatation are predictive of success. In selected patients, treatment with EBD may reduce or delay the need for surgery.
authors.affiliation: Department of Colorectal Surgery, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
authors.forename: Ashwinna
authors.initials: A
authors.lastname: Asairinachan
authors.affiliation: Department of Colorectal Surgery, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
authors.forename: Vinna
authors.initials: V
authors.lastname: An
authors.affiliation: Department of Colorectal Surgery, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
authors.forename: Eric S
authors.initials: ES
authors.lastname: Daniel
authors.affiliation: Department of Colorectal Surgery, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Johnston
authors.affiliation: Department of Colorectal Surgery, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Woods
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000328:Adult; D003251:Constriction, Pathologic / Q000209:etiology / Q000628:therapy*; D003424:Crohn Disease / Q000150:complications / Q000628:therapy*; D004106:Dilatation / Q000009:adverse effects* / Q000379:methods; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Crohn's disease; Crohn's stricture; complications; endoscopic balloon dilatation; outcomes