title: Development of Ion Chemosensors Based on Porphyrin Analogues.
abstract: Sensing of metal ions and anions is of great importance because of their widespread distribution in environmental systems and biological processes. Colorimetric and fluorescent chemosensors based on organic molecular species have been demonstrated to be effective for the detection of various ions and possess the significant advantages of low cost, high sensitivity, and convenient implementation. Of the available classes of organic molecules, porphyrin analogues possess inherently many advantageous features, making them suitable for the design of ion chemosensors, with the targeted sensing behavior achieved and easily modulated based on their following characteristics: (1) NH moieties properly disposed for binding of anions through cooperative hydrogen-bonding interactions; (2) multiple pyrrolic N atoms or other heteroatoms for selectively chelating metal ions; (3) variability of macrocycle size and peripheral substitution for modulation of ion selectivity and sensitivity; and (4) tunable near-infrared emission and good biocompatibility. In this Review, design strategies, sensing mechanisms, and sensing performance of ion chemosensors based on porphyrin analogues are described by use of extensive examples. Ion chemosensors based on normal porphyrins and linear oligopyrroles are also briefly described. This Review provides valuable information for researchers of related areas and thus may inspire the development of more practical and effective approaches for designing high-performance ion chemosensors based on porphyrin analogues and other relevant compounds.
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology , Shanghai 200237, P. R. China.|Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University , Nanjing, Jiangsu 210093, China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology , Shanghai 200237, P. R. China.
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Zhu
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology , Shanghai 200237, P. R. China.
authors.forename: Yongshu
authors.initials: Y
authors.lastname: Xie
mesh_terms: D002412:Cations / Q000032:analysis; D003124:Colorimetry; D005456:Fluorescent Dyes / Q000737:chemistry; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry
chemical_list: D002412:Cations; D005456:Fluorescent Dyes; D011166:Porphyrins; D011758:Pyrroles