title: A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants.
abstract: It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP.
  
  
  CONCLUSIONS
  When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.
  
  
  BACKGROUND
  •Tricyclic antidepressant can prolong the QT interval. It may be used for depression in pregnancy. What is New: •This is the first neonatal case report of prolonged QT interval and TdP caused by clomipramine transferred transplacentally from the mother.
authors.affiliation: Department of Cardiology, Tokyo Metropolitan Children's Medical Center, 2-8-29, Musashidai, Fuchu-shi, Tokyo, 183-8561, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Fukushima
authors.affiliation: Department of Pediatrics, Hino Municipal Hospital, 4-3-1, Tamadaira, Hino-shi, Tokyo, 191-0062, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nanao
authors.affiliation: Department of Pediatrics, Keio University Hospital, 25 Shinano-machi, Shinjunku-ku, Tokyo, 160-8582, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fukushima
authors.affiliation: Department of Forensic Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Kaumi 1-2-3, Minami-ku, Hiroshima, 734-8551, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Namera
authors.affiliation: Department of Cardiology, Tokyo Metropolitan Children's Medical Center, 2-8-29, Musashidai, Fuchu-shi, Tokyo, 183-8561, Japan. masaru_miura@tmhp.jp.
authors.forename: Masaru
authors.initials: M
authors.lastname: Miura
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000097:blood / Q000175:diagnosis*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D002997:Clomipramine / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000175:diagnosis*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine
keywords: Clomipramine; Desmethylclomipramine; Placental passage; Prolonged QT interval; Torsades de Pointes