title: Gait mechanics in those with/without medial compartment knee osteoarthritis 5 years after anterior cruciate ligament reconstruction.
abstract: The objective of the study was to evaluate differences in gait mechanics 5 years after unilateral anterior cruciate ligament reconstruction surgery, for non-osteoarthritic (n = 24) versus osteoarthritic (n = 9) subjects. For the involved knee, the osteoarthritic group demonstrated significantly lower peak knee flexion angles (non-osteoarthritic = 24.3 ± 4.6°, osteoarthritic = 19.1 ± 2.9°, p = 0.01) and peak knee flexion moments (non-osteoarthritic = 5.3 ± 1.2% Body Weight × Height, osteoarthritic = 4.4 ± 1.2% Body Weight × Height, p = 0.05). Differences in peak knee adduction moment approached significance, with a higher magnitude for the osteoarthritic group (non-osteoarthritic = 2.4 ± 0.8% Body Weight × Height, osteoarthritic = 2.9 ± 0.5% Body Weight × Height, p = 0.09). Peak medial compartment joint load was evaluated using electromyography-informed neuromusculoskeletal modeling. Peak medial compartment joint load in the involved knee for the two groups was not different (non-osteoarthritic = 2.4 ± 0.4 Body Weight, osteoarthritic = 2.3 ± 0.6 Body Weight). The results suggest that subjects with dissimilar peak knee moments can have similar peak medial compartment joint load magnitudes. There was no evidence of inter-limb asymmetry for either group. Given the presence of inter-group differences (non-osteoarthritic vs. osteoarthritic) for the involved knee, but an absence of inter-limb asymmetry in either group, it may be necessary to evaluate how symmetry is achieved, over time, and to differentiate between good versus bad inter-limb symmetry, when evaluating knee gait parameters. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:625-633, 2017.
authors.affiliation: Departmentof Biomedical Engineering, University of Delaware, 540 South College Avenue, Newark, Delaware, 19713.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Khandha
authors.affiliation: Department of Mechanical Engineering, University of Delaware, Newark, Delaware.
authors.forename: Kurt
authors.initials: K
authors.lastname: Manal
authors.affiliation: Department of Physical Therapy, University of Delaware, Newark, Delaware.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wellsandt
authors.affiliation: Department of Physical Therapy, University of Delaware, Newark, Delaware.
authors.forename: Jacob
authors.initials: J
authors.lastname: Capin
authors.affiliation: Department of Physical Therapy, University of Delaware, Newark, Delaware.
authors.forename: Lynn
authors.initials: L
authors.lastname: Snyder-Mackler
authors.affiliation: Departmentof Biomedical Engineering, University of Delaware, 540 South College Avenue, Newark, Delaware, 19713.|Department of Mechanical Engineering, University of Delaware, Newark, Delaware.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Buchanan
mesh_terms: D000328:Adult; D000070598:Anterior Cruciate Ligament Injuries / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D059549:Anterior Cruciate Ligament Reconstruction; D001696:Biomechanical Phenomena; D005260:Female; D005500:Follow-Up Studies; D005684:Gait; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D020370:Osteoarthritis, Knee / Q000209:etiology / Q000503:physiopathology*; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology*; D055815:Young Adult
keywords: ACL; ACLR; knee; musculoskeletal modeling; osteoarthritis