title: Antiviral activity of glycoprotein GP-1 isolated from Streptomyces kanasensis ZX01.
abstract: Plant virus diseases have seriously damaged global food security. However, current antiviral agents are not efficient enough for the requirement of agriculture production. So, developing new efficient and nontoxic antiviral agents is imperative. GP-1, from Streptomyces kanasensis ZX01, is a new antiviral glycoprotein, of which the antiviral activity and the mode of action against Tobacco mosaic virus (TMV) were investigated in this study. The results showed that GP-1 could fracture TMV particles, and the infection and accumulation of TMV in host plants were inhibited. Moreover, GP-1 could induce systematic resistance against TMV in the host, according to the results of activities of defensive enzymes increasing, MDA decreasing and overexpression of pathogenesis-related proteins. Furthermore, GP-1 could promote growth of the host plant. In conclusion, GP-1 showed the ability to be developed as an efficient antiviral agent and a fertilizer for agriculture.
authors.affiliation: Research & Development Center of Biorational Pesticide, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Research & Development Center of Biorational Pesticide, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Juntao
authors.initials: J
authors.lastname: Feng
authors.affiliation: Research & Development Center of Biorational Pesticide, Northwest A & F University, Yangling, Shaanxi 712100, China. Electronic address: lrhan2010@163.com.
authors.forename: Lirong
authors.initials: L
authors.lastname: Han
authors.affiliation: Research & Development Center of Biorational Pesticide, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006023:Glycoproteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010935:Plant Diseases / Q000821:virology; D013302:Streptomyces / Q000737:chemistry*; D014026:Nicotiana / Q000187:drug effects / Q000254:growth & development / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects* / Q000472:pathogenicity
chemical_list: D000998:Antiviral Agents; D006023:Glycoproteins
keywords: Glycoprotein GP-1; Induced systemic resistance; Tobacco mosaic virus