title: Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth.
abstract: Asthma is a chronic lung inflammation which affects many people. As current therapies for asthma mainly rely on administration of glucocorticoids and have many side effects, new therapy is needed. In this study, we investigated Nepeta bracteata Benth., a traditional Uygur Herb, for its therapeutics effect in OVA induced asthmatic mice model. Treatment of OVA sensitized asthma mice with extract from Nepeta bracteata Benth. demonstrated improved lung pathology, as well as reduced infiltration of eosinophil and neutrophil. Nepeta bracteata Benth. extract also contributed to the rebalance of Th17/Treg cell via decreasing the Th17 cell and increasing the Treg, which was corresponding with the inhibited Th17 cytokine response and increased IL-10 level. Moreover, the reduced TGF-β level and Smad2/3 protein level also suggested that Nepeta bracteata Benth. extract could inhibit TGF-β mediated airway remodelling as well. Taken together, these data suggested that Nepeta bracteata Benth. may be a novel candidate for future antiasthma drug development.
authors.affiliation: Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China; College of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China.
authors.forename: Feng-Sen
authors.initials: FS
authors.lastname: Li
authors.affiliation: First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Pang
authors.affiliation: Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Tian
authors.affiliation: Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China.
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Zhang
authors.affiliation: College of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
authors.forename: Jian-Bing
authors.initials: JB
authors.lastname: Ding