title: Clinical Features of Systemic Metastatic Retinal Lymphoma in Japanese Patients.
abstract: OBJECTIVE
  Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan.
  
  
  METHODS
  The clinical and pathologic features in SMRL at the Kyushu University Hospital were retrospectively studied.
  
  
  RESULTS
  The mean patient age at the onset of ocular involvement was 75.3 years. Four patients had brain involvement. The primary sites were: breast (2); chest (1); testis (1); intestinal tract (1); and nasal sinus (1). In all patients, the cytology of vitreous samples indicated diffuse large B-cell lymphoma (DLBCL).
  
  
  CONCLUSIONS
  DLBCL is the most common subtype in our study. The prevalence of CNS involvement in patients with SMRL is similar to that with PVRL. The testis and breast may be common sites of origin for SMRL.
authors.affiliation: a Department of Ophthalmology , Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan.
authors.forename: Rumiko
authors.initials: R
authors.lastname: Taki
authors.affiliation: a Department of Ophthalmology , Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan.
authors.forename: Atsunobu
authors.initials: A
authors.lastname: Takeda
authors.affiliation: a Department of Ophthalmology , Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: a Department of Ophthalmology , Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Fukuhara
authors.affiliation: a Department of Ophthalmology , Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Arita
authors.affiliation: b Department of Haematology , National Hospital Organization Kyushu Cancer Center , Fukuoka , Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Suehiro
authors.affiliation: b Department of Haematology , National Hospital Organization Kyushu Cancer Center , Fukuoka , Japan.
authors.forename: Ilseung
authors.initials: I
authors.lastname: Choi
authors.affiliation: c Ohshima Hospital of Ophthalmology , Fukuoka , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kumano
authors.affiliation: d Nakamura Eye Center , Dazaifu , Fukuoka , Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: a Department of Ophthalmology , Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishibashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007414:Intestinal Neoplasms / Q000473:pathology; D007564:Japan / Q000453:epidemiology; D008207:Lymphatic Metastasis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000208:ethnology / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D010255:Paranasal Sinus Neoplasms / Q000473:pathology; D016133:Polymerase Chain Reaction; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000378:metabolism; D012189:Retrospective Studies; D013736:Testicular Neoplasms / Q000473:pathology; D013899:Thoracic Neoplasms / Q000473:pathology; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology
chemical_list: D007143:Immunoglobulin Heavy Chains; D009363:Neoplasm Proteins
keywords: CNS involvement; Clinical features; primary organs; single-center study; vitreoretinal lymphoma