title: Heat stroke during long-term clozapine treatment: should we be concerned about hot weather?
abstract: OBJECTIVE
  To describe the case of a patient with schizophrenia on clozapine treatment who had an episode of heat stroke.
  
  
  METHODS
  During a heat wave in January and February 2014, a patient with schizophrenia who was on treatment with clozapine was initially referred for differential diagnose between systemic infection and neuroleptic malignant syndrome, but was finally diagnosed with heat stroke and treated with control of body temperature and hydration.
  
  
  CONCLUSIONS
  This report aims to alert clinicians take this condition into consideration among other differential diagnoses, especially nowadays with the rise in global temperatures, and to highlight the need for accurate diagnosis of clinical events during pharmacological intervention, in order to improve treatment decisions and outcomes.
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Maurício Scopel
authors.initials: MS
authors.lastname: Hoffmann
authors.affiliation: Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Lucas Mendes
authors.initials: LM
authors.lastname: Oliveira
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Maria Inês Rodrigues
authors.initials: MI
authors.lastname: Lobato
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Belmonte-de-Abreu
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D018883:Heat Stroke / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis; D012559:Schizophrenia / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine