title: Acetyl-DL-leucine improves gait variability in patients with cerebellar ataxia-a case series.
abstract: Acetyl-DL-leucine is a modified amino acid that was observed to improve ataxic symptoms in patients with sporadic and hereditary forms of ataxia. Here, we investigated the effect of the treatment with Acetyl-DL-leucine on the walking stability of patients with cerebellar ataxia (10x SAOA, 2x MSA-C, 2x ADA, 1x CACNA-1A mutation, 2x SCA 2, 1x SCA 1). Treatment with Acetyl-DL-leucine (500 mg; 3-3-4) significantly improved the coefficient of variation of stride time in 14 out of 18 patients. Moreover, subjective ambulatory scores (FES-I and ABC) and the SARA scores were also improved under treatment. Further prospective studies are necessary to support these class III observational findings.
authors.affiliation: Department of Neurology, University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany ; German Center for Vertigo and Balance Disorders (DSGZ), University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Schniepp
authors.affiliation: Department of Neurology, University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany ; German Center for Vertigo and Balance Disorders (DSGZ), University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Strupp
authors.affiliation: German Center for Vertigo and Balance Disorders (DSGZ), University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany.
authors.forename: Max
authors.initials: M
authors.lastname: Wuehr
authors.affiliation: German Center for Vertigo and Balance Disorders (DSGZ), University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany ; Schoen Klinik Bad Aibling, Neurologie, Kolbermoorer Strasse 72, Bad Aibling, 83043 Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Jahn
authors.affiliation: Department of Neurology, University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany ; German Center for Vertigo and Balance Disorders (DSGZ), University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Dieterich
authors.affiliation: German Center for Vertigo and Balance Disorders (DSGZ), University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany ; Institute of Clinical Neurosciences, University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brandt
authors.affiliation: Department of Neurology, University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany ; German Center for Vertigo and Balance Disorders (DSGZ), University of Munich, Campus Großhadern, Marchioninistrasse 15, Munich, 81377 Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Feil
keywords: Acetyl-DL-leucine; Cerebellar ataxia; Gait variability; Speed dependency; symptomatic treatment