title: The value of plasma netrin-1 in non-small cell lung cancer patients as diagnostic and prognostic biomarker.
abstract: Netrin-1 is found to be elevated and purposive as a diagnostic biomarker in many human cancers. We evaluated serum netrin-1 concentrations in patients with advanced non-small cell lung cancer compared with those in a healthy group. Thirty patients with advanced non-small cell lung cancer and 30 healthy people were included in the study. Serum netrin-1 concentrations were measured by quantitative ELISA method in both groups. The mean serum netrin-1 concentrations were found to be significantly higher in patients with non-small cell lung cancer than in healthy controls. The mean serum netrin-1 concentrations were found to be significantly higher in patients with non-small cell lung cancer before the beginning of chemotherapy when compared after the completion of the third cycle. Our results represented that netrin-1 concentrations elevated in advanced non-small cell lung cancer compared to a healthy control group, and netrin-1 concentrations decreased with chemotherapy.
authors.affiliation: Department of Medical Oncology, Dr. Lutfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey. behemots@hotmail.com.
authors.forename: Mahmut Emre
authors.initials: ME
authors.lastname: Yıldırım
authors.affiliation: Department of Medical Oncology, School of Medicine, Kocaeli University, Kocaeli, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Kefeli
authors.affiliation: Department of Medical Oncology, Dr. Lutfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey.
authors.forename: Dinçer
authors.initials: D
authors.lastname: Aydın
authors.affiliation: Department of Medical Oncology, Dr. Lutfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Sener
authors.affiliation: Department of Medical Oncology, School of Medicine, Bezmialem University, Istanbul, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gümüş
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D000075388:Netrin-1; D011237:Predictive Value of Tests; D011379:Prognosis; D016896:Treatment Outcome; D025521:Tumor Suppressor Proteins / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1
keywords: Biomarker; Gastric cancer; Netrin-1; Treatment