title: Description and Prevalence of Spondyloarthritis in Patients with Anterior Uveitis: The SENTINEL Interdisciplinary Collaborative Project.
abstract: To describe and analyze the prevalence of spondyloarthritis (SpA) in patients with anterior uveitis (AU).
  
  
  
  Multicentric, observational, prospective study.
  
  
  
  Consecutive patients with AU who were human leukocyte antigen (HLA)-B27 positive or HLA-B27 negative with more than 1 episode of AU separated by at least 3 months were selected. Patients with a previous diagnosis of SpA were excluded.
  
  
  
  Included patients were evaluated by an ophthalmologist and a rheumatologist following a predefined visit schedule.
  
  
  
  Sociodemographic and clinical variables including the diagnosis of SpA according to Assessment of SpondyloArthritis International Society (ASAS) criteria and an exhaustive ophthalmological examination (best-corrected visual acuity, intraocular pressure, biomicroscopic examination of the anterior and posterior segment of the eye, cataract evaluation, optical coherence tomography evaluating both the 1-mm central retina thickness and the optic nerve head and retinal nerve fiber layer, and visual field in a dark room with 1 eye patched) were collected. Baseline descriptive, bivariate, and concordance analyses were performed.
  
  
  
  We included 798 patients, mostly men (59%) with a mean age of 45 years; 60% were AU HLA-B27 positive, and 40% had recurrent negative AU HLA-B27. A total of 50.2% and 17.5% of patients presented axial and peripheral SpA according to ASAS criteria, respectively. Patients with AU who were HLA-B27 positive were more frequently diagnosed with axial (69.8% vs. 27.3%, P < 0.0001) and peripheral SpA (21.9% vs. 11.1%, P < 0.0001) than patients with recurrent negative AU HLA-B27. In general, we did not detect important differences between groups in the ophthalmologic variables.
  
  
  
  A large percentage of patients with clinically significant AU have an undiagnosed SpA. This percentage is even higher if the HLA-B27 haplotype is positive.
authors.affiliation: Rheumatology Unit, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Juanola
authors.affiliation: Instituto de Salud Musculoesquelética, Madrid, Spain. Electronic address: estibaliz.loza@inmusc.eu.
authors.forename: Estíbaliz
authors.initials: E
authors.lastname: Loza Santamaría
authors.affiliation: Uveitis Unit, University Hospital of León, León, Spain; Instituto de Biomedicina (IBIOMED), University of Leon, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cordero-Coma
mesh_terms: D000328:Adult; D005260:Female; D015796:HLA-B27 Antigen / Q000276:immunology; D006801:Humans; D058025:Interdisciplinary Studies; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D015995:Prevalence; D011446:Prospective Studies; D012160:Retina / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology; D013030:Spain / Q000453:epidemiology; D025241:Spondylarthritis / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D041623:Tomography, Optical Coherence; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology
chemical_list: D015796:HLA-B27 Antigen