title: The mammalian circadian clock and its entrainment by stress and exercise.
abstract: The mammalian circadian clock regulates day-night fluctuations in various physiological processes. The circadian clock consists of the central clock in the suprachiasmatic nucleus of the hypothalamus and peripheral clocks in peripheral tissues. External environmental cues, including light/dark cycles, food intake, stress, and exercise, provide important information for adjusting clock phases. This review focuses on stress and exercise as potent entrainment signals for both central and peripheral clocks, especially in regard to the timing of stimuli, types of stressors/exercises, and differences in the responses of rodents and humans. We suggest that the common signaling pathways of clock entrainment by stress and exercise involve sympathetic nervous activation and glucocorticoid release. Furthermore, we demonstrate that physiological responses to stress and exercise depend on time of day. Therefore, using exercise to maintain the circadian clock at an appropriate phase and amplitude might be effective for preventing obesity, diabetes, and cardiovascular disease.
authors.affiliation: Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Wakamatsu 2-2, Shinjuku, Tokyo, 162-8480, Japan.|Waseda Institute for Advanced Study, Waseda University, Tokyo, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tahara
authors.affiliation: Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Wakamatsu 2-2, Shinjuku, Tokyo, 162-8480, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Aoyama
authors.affiliation: Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Wakamatsu 2-2, Shinjuku, Tokyo, 162-8480, Japan. shibatas@waseda.jp.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Shibata
mesh_terms: D000818:Animals; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D017440:Photoperiod; D010805:Physical Conditioning, Animal / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000502:physiology
keywords: Liver; Mammalian circadian clock; Muscle; Oxidative stress