title: A general chemical shift decomposition method for hyperpolarized (13) C metabolite magnetic resonance imaging.
abstract: Metabolic imaging with hyperpolarized carbon-13 allows sequential steps of metabolism to be detected in vivo. Potential applications in cancer, brain, muscular, myocardial, and hepatic metabolism suggest that clinical applications could be readily developed. A primary concern in imaging hyperpolarized nuclei is the irreversible decay of the enhanced magnetization back to thermal equilibrium. Multiple methods for rapid imaging of hyperpolarized substrates and their products have been proposed with a multi-point Dixon method distinguishing itself as a robust protocol for imaging [1-(13) C]pyruvate. We describe here a generalized chemical shift decomposition method that incorporates a single-shot spiral imaging sequence plus a spectroscopic sequence to retain as much spin polarization as possible while allowing detection of metabolites that have a wide range of chemical shift values. The new method is demonstrated for hyperpolarized [1-(13) C]pyruvate, [1-(13) C]acetoacetate, and [2-(13) C]dihydroxyacetone. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Jian-Xiong
authors.initials: JX
authors.lastname: Wang
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Merritt
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Sherry
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Craig R
authors.initials: CR
authors.lastname: Malloy
mesh_terms: D000090:Acetoacetates / Q000737:chemistry; D000465:Algorithms; D000818:Animals; D001711:Biotransformation; D002247:Carbon Isotopes; D004098:Dihydroxyacetone / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008660:Metabolism; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D019289:Pyruvic Acid / Q000737:chemistry; D051381:Rats; D013816:Thermodynamics
chemical_list: D000090:Acetoacetates; D002247:Carbon Isotopes; C016635:acetoacetic acid; D019289:Pyruvic Acid; C000615229:Carbon-13; D004098:Dihydroxyacetone
keywords: 13C MR; chemical shift; decomposition; hyperpolarized; metabolite imaging