title: Mania associated with ranitidine: a case report and review of literature.
abstract: H2 receptor antagonists can be associated with central adverse drug reactions (ADRs), like confusion, delirium, hallucinations, slurred speech or headaches. We report here a 'serious' case of severe mania leading to hospitalization in a 42-year-old alcohol-dependent man, 4 days after ranitidine introduction. Review of literature showed that this 'very rare' ADR occurs mainly in patients with predisposing factors: age, decrease in renal and/or hepatic function, polymedication, alcohol. Knowledge of this ADR can be particularly important for these drugs widely used as self-medication.
authors.affiliation: Department of Medical and Clinical Pharmacology, Pharmacopôle Midi-Pyrénées, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Mauran
authors.affiliation: Department of Psychiatry and Medical Psychology, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: Tudi
authors.initials: T
authors.lastname: Goze
authors.affiliation: Department of Medical and Clinical Pharmacology, Pharmacopôle Midi-Pyrénées, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Abadie
authors.affiliation: Department of Medical and Clinical Pharmacology, Pharmacopôle Midi-Pyrénées, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Bondon-Guitton
authors.affiliation: Department of Gastroenterology, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Chevrel
authors.affiliation: Department of Psychiatry and Medical Psychology, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Schmitt
authors.affiliation: Department of Medical and Clinical Pharmacology, Pharmacopôle Midi-Pyrénées, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montastruc
authors.affiliation: Department of Medical and Clinical Pharmacology, Pharmacopôle Midi-Pyrénées, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France.
authors.forename: François
authors.initials: F
authors.lastname: Montastruc
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis*; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000009:adverse effects*
chemical_list: D006635:Histamine H2 Antagonists; D011899:Ranitidine
keywords: H2 receptor antagonists; mania; psychiatric adverse drug reactions; ranitidine; self-medication