title: Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype.
abstract: Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date. One-third of reported cases of breast acinic cell carcinoma have been associated with the presence of a ductal carcinoma not otherwise specified component, which is frequently poorly differentiated. Breast acinic cell carcinoma can demonstrate focal morphologic features similar to microglandular adenosis; these areas are frequently negative for collagen IV and laminin on immunohistochemistry. The true relationship between these 2 entities remains unclear, but we advocate that microglandular adenosis-like areas at the periphery of a breast acinic cell carcinoma should be considered part of the carcinomatous process and re-excised if this process extends to the initial surgical margins.
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065. Electronic address: conlon_niamh@hotmail.com.
authors.forename: Niamh
authors.initials: N
authors.lastname: Conlon
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
authors.forename: Navid
authors.initials: N
authors.lastname: Sadri
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
authors.forename: Adriana D
authors.initials: AD
authors.lastname: Corben
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
authors.forename: Lee K
authors.initials: LK
authors.lastname: Tan
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018267:Carcinoma, Acinar Cell / Q000473:pathology*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology
keywords: Acinic cell carcinoma of breast; Immunohistochemistry; Molecular pathology; Morphology; Triple-negative breast cancer