title: Fixed-dose combinations of antimicrobials: A need for special attention.
abstract: OBJECTIVE
  To highlight the issue of freely available fixed-dose combinations (FDCs) of antimicrobials.
  
  
  METHODS
  A critique of two such antimicrobial FDCs was undertaken wherein the following aspects were assessed - rational and regulatory issues and justification for clinical use. Available in vitro, in vivo (animals and humans) evidence from published literature was analysed.
  
  
  CONCLUSIONS
  There are several inadequately addressed aspects of the considered FDCs which are available in Indian market. In view of the growing problem of antimicrobial resistance, this issue must get the required attention.
authors.affiliation: Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012, India.
authors.forename: N
authors.initials: N
authors.lastname: Shafiq
authors.forename: G
authors.initials: G
authors.lastname: Kumar
authors.forename: V
authors.initials: V
authors.lastname: Gautam
authors.forename: P
authors.initials: P
authors.lastname: Ray
authors.forename: S
authors.initials: S
authors.lastname: Malhotra
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000188:drug therapy / Q000662:veterinary; D004338:Drug Combinations; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations