title: Tazobactam and piperacillin-induced thrombocytopenia: A case report.
abstract: The present study reports a case of tazobactam and piperacillin (TZP)-induced thrombocytopenia in an elderly patient, from which complete clinical data and peripheral blood samples were collected. Platelet numbers were decreased 1 day following TZP treatment initiation; however, they were revealed to have increased 1-2 days following withdrawal of TZP, and had reached normal levels 3-5 days later. There was no evidence of bone marrow suppression, antibodies against peripheral plasma platelets were absent and levels of complement C3 were decreased. These results suggested that TZP was able to cause rapid and reversible thrombocytopenia, which was not associated with bone marrow suppression but may have involved activation of complement C3. The results of the present study therefore suggest that doctors should be aware of the risk of thrombocytopenia in patients treated with TZP.
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Clinical Laboratory, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Yudan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: LE
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China; Intensive Care Unit, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhu
keywords: piperacillin-tazobactam; thrombocytopenia