title: [Hypoxic lung failure].
abstract: Hypoxic lung failure is among the major indications for patients' referral to intensive care units either for surveillance or if necessary therapy. There are a vast number of pathophysiological causes of lung failure and the optimal treatment highly depends on the underlying pathology; therefore, no standard algorithm exists. So-called acute respiratory distress syndrome (ARDS) represents a very severe manifestation of hypoxemic lung failure that is of particular relevance for intensivists and is therefore the focus of this review. In addition to fundamental pathophysiology of lung injury, the article also focuses on established and modern treatment strategies. Moreover, we will briefly highlight innovative concepts of ARDS treatment that might become relevant in the future.
authors.affiliation: Zentrum Innere Medizin - Internistische Intensivstation, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. david.sascha@mh-hannover.de.
authors.forename: S
authors.initials: S
authors.lastname: David
authors.affiliation: Zentrum Innere Medizin - Internistische Intensivstation, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: O
authors.initials: O
authors.lastname: Wiesner
mesh_terms: D000328:Adult; D003422:Critical Care / Q000379:methods*; D006801:Humans; D006935:Hypercapnia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007223:Infant; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy / Q000379:methods; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D014692:Ventilation-Perfusion Ratio / Q000502:physiology
keywords: Hypoxemia; Hypoxia; Lung injury; Respiratory distress syndrome, acute; Ventilation