title: Efficacy and safety of endoscopic submucosal dissection for elderly patients with superficial squamous esophageal neoplasms.
abstract: BACKGROUND
  Little is known about the outcomes of endoscopic submucosal dissection in elderly patients with superficial squamous esophageal neoplasms.
  
  
  OBJECTIVE
  To assess the efficacy and safety of endoscopic submucosal dissection for superficial squamous esophageal neoplasms in elderly patients (≥65 years) compared with non-elderly patients.
  
  
  METHODS
  All patients with superficial squamous esophageal neoplasms receiving endoscopic submucosal dissection were retrospectively analyzed. Among them, 130 were aged 65 or older (group A), and 201 were aged younger than 65 years (group B). Therapeutic efficacy, adverse events, and follow-up data were evaluated.
  
  
  RESULTS
  Group A had a higher prevalence of concomitant diseases than group B (52.3% vs. 14.9%, respectively). R0 resection rate was 82.3% in group A and 84.6 % in group B (P = 0.717). The curative resection rate was 80.8% in group A and 83.6% in group B (P = 0.653). The rate of procedure-related non-cardiopulmonary adverse events was 20.8% in group A and 16.9% in group B (P = 0.377). The incidence of cardiopulmonary adverse events during or after the procedure was 6.2% in group A and 2.5% in group B (P = 0.094). No procedure-related mortality was reported in either group.
  
  
  CONCLUSIONS
  Endoscopic submucosal dissection is effective and safe for treating superficial squamous esophageal neoplasms in elderly patients.
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China; Drum Tower Hospital, Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Guifang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Tingsheng
authors.initials: T
authors.lastname: Ling
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Xiwei
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zou
keywords: Endoscopic submucosal dissection; elderly patient; endoscopic mucosal resection; esophageal cancer; esophageal neoplasm