title: Skin Rash and Microscopic Hematuria in a 10-Year-Old Caucasian Male.
abstract: OBJECTIVE
  Henoch-Schonlein purpura (HSP) is an acute, systemic, vasculitis with IgA-dominant immune deposits. With the emphasis on educational value of HSP, which is the most common form of vasculitis in children, we report an actual case from a 10-year-old boy.
  
  
  METHODS
  The patient presented with the chief complaint of a skin rash. His illness history, family medical history, physical examination, and relevant laboratory findings were summarized, followed by a question and possible answer format discussion.
  
  
  CONCLUSIONS
  With the significant elevation of red blood cells in his urine and moderate to severe deposition of IgA in kidney biopsy, the patient was diagnosed with HSP nephritis. Renal symptoms, such as proteinuria and hematuria, are mostly the last to develop and determine the long-term prognosis in HSP patients. The patient is currently undergoing steroid treatment, which is the primary intervention for HSP as it spontaneously resolves in most of affected children.
authors.affiliation: Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, and aookorod@utmb.edu.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cao
authors.affiliation: Department of Pathology, University of Texas Medical Branch-Galveston, Galveston, Texas aookorod@utmb.edu.
authors.forename: Rejwi A
authors.initials: RA
authors.lastname: Dahal
authors.affiliation: Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, and.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Pathology, University of Texas Medical Branch-Galveston, Galveston, Texas.
authors.forename: John R
authors.initials: JR
authors.lastname: Petersen
authors.affiliation: Department of Pathology, University of Texas Medical Branch-Galveston, Galveston, Texas aookorod@utmb.edu.
authors.forename: Anthony O
authors.initials: AO
authors.lastname: Okorodudu
mesh_terms: D002648:Child; D004912:Erythrocytes / Q000473:pathology*; D005076:Exanthema / Q000175:diagnosis*; D006417:Hematuria / Q000175:diagnosis*; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis* / Q000188:drug therapy; D007070:Immunoglobulin A / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008297:Male; D012075:Remission, Spontaneous; D013256:Steroids / Q000627:therapeutic use
chemical_list: D007070:Immunoglobulin A; D013256:Steroids
keywords: Arthritis; Henoch-Schonlein purpura (HSP); IgA; hematuria; skin rash; vasculitis