title: Metabolic dysregulation in first-episode schizophrenia patients with respect to genetic variation in one-carbon metabolism.
abstract: The aim of this study was to investigate the prevalence of metabolic disturbances in patients with first-episode schizophrenia (FES) and test the hypothesis that genetic variation in one-carbon metabolism may account for metabolic dysregulation in early psychosis. We measured fasting glucose, lipid profile parameters, homocysteine, folate and vitamin B12 in 135 patients with FES and 146 healthy controls (HCs). Polymorphisms in the following genes were determined: MTHFR (C677T and A1298C), MTHFD1 (G1958A), MTRR (A66G) and BHMT (G742A). Serum levels of folate and high-density lipoproteins (HDL) were significantly lower in patients with FES compared to HCs. In turn, serum levels of homocysteine and triglycerides were significantly higher in patients with FES than in HCs. Prevalence of hyperhomocysteinemia, low folate and HDL levels together with dyslipidemia was significantly higher in patients with FES compared to HCs. Higher homocysteine levels, lower vitamin B12 levels and the presence of metabolic syndrome were associated with higher severity of negative symptoms. None of studied polymorphisms was associated with schizophrenia risk. Several associations between studied polymorphisms and cardio-metabolic parameters were found. None of them remained significant after Bonferroni correction. Our results indicate that metabolic dysregulation in patients with FES is not associated with genetic variation in one-carbon metabolism.
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland. Electronic address: mblazej@interia.eu.
authors.forename: Błażej
authors.initials: B
authors.lastname: Misiak
authors.affiliation: Department of Endocrinology and Diabetology, 4 Pasteur Street, 50-367 Wroclaw, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Łaczmański
authors.affiliation: Department of Endocrinology and Diabetology, 4 Pasteur Street, 50-367 Wroclaw, Poland.
authors.forename: Natalia Kinga
authors.initials: NK
authors.lastname: Słoka
authors.affiliation: Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Szmida
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
authors.forename: Patryk
authors.initials: P
authors.lastname: Piotrowski
authors.affiliation: Department of Professional Training in Clinical Chemistry, Wroclaw Medical University, 211A Borowska Street, 50-566 Wroclaw, Poland.
authors.forename: Olga
authors.initials: O
authors.lastname: Loska
authors.affiliation: Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Ślęzak
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kiejna
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Frydecka
mesh_terms: D000328:Adult; D050940:Betaine-Homocysteine S-Methyltransferase / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D002244:Carbon / Q000378:metabolism; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology / Q000523:psychology*; D005215:Fasting / Q000097:blood; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000453:epidemiology / Q000523:psychology*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000523:psychology*; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D015778:Minor Histocompatibility Antigens / Q000235:genetics; D019875:One-Carbon Group Transferases; D011110:Polymorphism, Genetic; D015995:Prevalence; D011618:Psychotic Disorders / Q000097:blood / Q000150:complications* / Q000235:genetics; D012559:Schizophrenia / Q000097:blood* / Q000150:complications / Q000235:genetics; D014280:Triglycerides / Q000097:blood; D014805:Vitamin B 12; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D015778:Minor Histocompatibility Antigens; D014280:Triglycerides; D006710:Homocysteine; D002244:Carbon; D005492:Folic Acid; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C539735:MTHFD1 protein, human; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D019875:One-Carbon Group Transferases; C494548:BHMT protein, human; D050940:Betaine-Homocysteine S-Methyltransferase; D014805:Vitamin B 12
keywords: Folate; Gene; Homocysteine; Metabolic syndrome; Polymorphism; Psychosis