title: Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model.
abstract: The aim of the present study was to investigate the expression of caveolin-1 in rat brain glioma tissue, and to determine whether interleukin-1β (IL-1β) has a role in this process. Using glioma cells, a tumor-burdened rat model was established, and the expression of caveolin-1 protein in the tumor sites was significantly increased following intracarotid infusion of IL-1β (3.7 ng/kg/min), as indicated by western blot analysis. The maximum value of the caveolin-1 expression was observed in tumor-burdened rats after 60 min of IL-1β perfusion, and which was significantly enhanced by vascular endothelial growth factor (VEGF). In addition, VEGF also significantly increased IL-1β-induced blood tumor barrier (BTB) permeability. The results suggest that the IL-1β-induced BTB permeability increase may be associated with the expression of caveolin-1 protein, and VEGF may be involved in this process.
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Qin
authors.affiliation: Department of Chinese Medicine, College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China.
authors.forename: Yong-Sen
authors.initials: YS
authors.lastname: Jia
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China.
authors.forename: Yi-Bing
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China.
authors.forename: Yin-Huan
authors.initials: YH
authors.lastname: Wang
keywords: caveolae; caveolin-1; glioma; interleukin-1β; vascular endothelial growth factor