title: Analysis of Counterfeit Coated Tablets and Multi-Layer Packaging Materials Using Infrared Microspectroscopic Imaging.
abstract: An effective method for detecting and characterizing counterfeit finished dosage forms and packaging materials is described in this study. Using attenuated total internal reflection Fourier transform infrared spectroscopic imaging, suspect tablet coating and core formulations as well as multi-layered foil safety seals, bottle labels, and cigarette tear tapes were analyzed and compared directly with those of a stored authentic product. The approach was effective for obtaining molecular information from structures as small as 6 μm.
authors.affiliation: 1Molecular Microspectroscopy Laboratory,Department of Chemistry and Biochemistry,Miami University,Oxford,Ohio,USA.
authors.forename: Taryn L
authors.initials: TL
authors.lastname: Winner
authors.affiliation: 2United States Food and Drug Administration Forensic Chemistry Center,Cincinnati,Ohio,USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Lanzarotta
authors.affiliation: 1Molecular Microspectroscopy Laboratory,Department of Chemistry and Biochemistry,Miami University,Oxford,Ohio,USA.
authors.forename: André J
authors.initials: AJ
authors.lastname: Sommer
keywords: ATR; FTIR; counterfeit; packaging; pharmaceuticals