title: Expansion of Shiga Toxin-Producing Escherichia coli by Use of Bovine Antibiotic Growth Promoters.
abstract: Antibiotics are routinely used in food-producing animals to promote growth and prevent infectious diseases. We investigated the effects of bovine antibiotic growth promoters (bAGPs) on the propagation and spread of Shiga toxin (Stx)-encoding phages in Escherichia coli. Co-culture of E. coli O157:H7 and other E. coli isolated from cattle in the presence of sublethal concentrations of bAGPs significantly increased the emergence of non-O157, Stx-producing E. coli by triggering the SOS response system in E. coli O157:H7. The most substantial mediation of Stx phage transmission was induced by oxytetracyline and chlortetracycline, which are commonly used in agriculture. bAGPs may therefore contribute to the expansion of pathogenic Stx-producing E. coli.
authors.forename: Jong-Chul
authors.initials: JC
authors.lastname: Kim
authors.forename: Linda
authors.initials: L
authors.lastname: Chui
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Shen
authors.forename: Byeonghwa
authors.initials: B
authors.lastname: Jeon
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001435:Bacteriophages / Q000502:physiology; D002417:Cattle; D004927:Escherichia coli Infections / Q000382:microbiology*; D022621:Shiga Toxin / Q000096:biosynthesis*; D054323:Shiga-Toxigenic Escherichia coli / Q000187:drug effects* / Q000378:metabolism* / Q000821:virology; D014161:Transduction, Genetic; D014779:Virus Replication
chemical_list: D000900:Anti-Bacterial Agents; D022621:Shiga Toxin
keywords: E. coli; STEC; Shiga toxin–producing Escherichia coli; Stx-encoding bacteriophages; antimicrobial resistance; bacteria; bovine antibiotic growth promoters