title: Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows.
abstract: The failure to adapt metabolism to the homeorhetic demands of lactation is considered as a main factor in reducing the productive life span of dairy cows. The so far defined markers of production performance and metabolic health in dairy cows do not predict the length of productive life span satisfyingly. This study aimed to identify novel pathways and biomarkers related to productive life in dairy cows by means of (targeted) metabolomics. In a longitudinal study from 42 days before up to 100 days after parturition, we identified metabolites such as long-chain acylcarnitines and biogenic amines associated with extended productive life spans. These metabolites are mainly secreted by the liver and depend on the functionality of hepatic mitochondria. The concentrations of biogenic amines and some acylcarnitines differed already before the onset of lactation thus indicating their predictive potential for continuation or early ending of productive life.
authors.affiliation: Institute of Animal Science, University of Hohenheim, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Huber
authors.affiliation: Institute of Animal Nutrition, Federal Research Institute for Animal Health, Braunschweig, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Dänicke
authors.affiliation: Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Rehage
authors.affiliation: Institute for Animal Science, University of Bonn, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Sauerwein
authors.affiliation: Department of Proteomics, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Otto
authors.affiliation: Department of Metabolomics, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Rolle-Kampczyk
authors.affiliation: Department of Proteomics, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.|Department of Metabolomics, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.|Department of Chemistry and Life Sciences, University of Aalborg, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: von Bergen
mesh_terms: D000108:Acetylcarnitine / Q000097:blood; D000818:Animals; D001679:Biogenic Amines / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002417:Cattle / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D005260:Female; D007774:Lactation; D008136:Longevity; D055442:Metabolome; D008930:Mitochondria, Liver / Q000378:metabolism
chemical_list: D001679:Biogenic Amines; D015415:Biomarkers; D000108:Acetylcarnitine