title: The comparison of dextranomer/hyaluronic acid and polyacrylate-polyalcohol copolymers in endoscopic treatment of vesicoureteral reflux.
abstract: BACKGROUND
  Dextranomer/hyaluronic acid (Dx/Ha;Dexell®) and polyacrylate-polyalcohol copolymer (PPC;Vantris®) are the popular tissue-augmenting substances using for the endoscopic injections of vesicoureteral reflux (VUR). The aim of the study is to evaluate and compare Dx/Ha and PPC in terms of effectiveness, injection techniques and complications with special emphasis on vesicoureteral junction obstruction (VUJO).
  
  
  METHODS
  A total of 95 patients who underwent endoscopic VUR treatment between 2009 and 2015 were retrospectively reviewed. The patients were divided into two groups: group 1: Patients underwent endoscopic treatment with PPC (n=50 patients, 70 renal refluxing units) group 2: Patients underwent endoscopic treatment with Dx/Ha (n=45 patients, 74 renal refluxing units).
  
  
  RESULTS
  The overall resolution rates based on the number of renal refluxing units studied was 88.6% and 70.3% in group 1 and group 2, respectively. Resolution rates were significantly better in group 1 compared to group 2. VUJO requiring ureteral reimplantation or stent insertion developed in 7 patients in group 1. No VUJO was observed in group 2. VUJO in group 1 was markedly higher than that in group 2.
  
  
  CONCLUSIONS
  Endoscopic treatment of VUR with PPC promises better resolution rates but higher VUJO rates compared to Dx/Ha.
authors.affiliation: University of Gaziantep, Faculty of Medicine, Department of Pediatric Surgery, Gaziantep, Turkey. Electronic address: sckarakus@yahoo.com.
authors.forename: Suleyman Cuneyt
authors.initials: SC
authors.lastname: Karakus
authors.affiliation: University of Gaziantep, Faculty of Medicine, Department of Pediatric Surgery, Gaziantep, Turkey.
authors.forename: İdil Rana
authors.initials: İR
authors.lastname: User
authors.affiliation: University of Gaziantep, Faculty of Medicine, Department of Pediatric Nephrology, Gaziantep, Turkey.
authors.forename: Beltinge Demircioglu
authors.initials: BD
authors.lastname: Kılıc
authors.affiliation: University of Gaziantep, Faculty of Medicine, Department of Pediatric Surgery, Gaziantep, Turkey.
authors.forename: Vedat
authors.initials: V
authors.lastname: Akçaer
authors.affiliation: University of Gaziantep, Faculty of Medicine, Department of Pediatric Surgery, Gaziantep, Turkey.
authors.forename: Haluk
authors.initials: H
authors.lastname: Ceylan
authors.affiliation: University of Gaziantep, Faculty of Medicine, Department of Pediatric Surgery, Gaziantep, Turkey.
authors.forename: Bulent Hayri
authors.initials: BH
authors.lastname: Ozokutan
mesh_terms: D000180:Acrylic Resins / Q000627:therapeutic use*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003911:Dextrans / Q000627:therapeutic use*; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007223:Infant; D007267:Injections; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014718:Vesico-Ureteral Reflux / Q000628:therapy*
chemical_list: D000180:Acrylic Resins; D003911:Dextrans; C530415:Vantris; C487487:dextranomer-hyaluronic acid copolymer; D006820:Hyaluronic Acid
keywords: Dextranomer; Double HIT; Polyacrylate-polyalcohol; STING; Vesicoureteral reflux