title: Copper-Catalyzed Borylative Aromatization ofp-Quinone Methides: Enantioselective Synthesis of Dibenzylic Boronates.
abstract: In this report, we establish that DM-Segphos copper(I) complexes are efficient catalysts for the enantioselective borylation ofpara-quinone methides. This method provides straightforward access to chiral monobenzylic and dibenzylic boronic esters, with enantiomeric ratios up to 96:4, using a commercially available chiral phosphine. Standard manipulations of the C-B bond afford a variety of chiral diaryl derivatives.
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Jarava-Barrera
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Parra
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
authors.forename: Aurora
authors.initials: A
authors.lastname: López
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
authors.forename: Fabio
authors.initials: F
authors.lastname: Cruz-Acosta
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Collado-Sanz
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
authors.forename: Diego J
authors.initials: DJ
authors.lastname: Cárdenas
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
authors.forename: Mariola
authors.initials: M
authors.lastname: Tortosa
keywords: asymmetric catalysis; asymmetric synthesis; boron; copper; synthetic methods