title: Adipose stromal cells improve healing of vocal fold scar: Morphological and functional evidences.
abstract: Adipose derived stromal cells (ASCs) are abundant and easy to prepare. Such cells may be useful for treating severe vocal disturbance caused by acute vocal fold scars.
  
  
  
  Prospective animal experiments with controls.
  
  
  
  Twenty New-Zealand white rabbits were used in the present study. We evaluated vocal fold healing, with or without injection of autologous ASCs, after acute scarring. A defined lesion was created and the ASCs were immediately injected. Vocal fold regeneration was evaluated histomorphometrically and via viscoelastic analysis using an electrodynamic shaker.
  
  
  
  Six weeks after ASC injection, vocal folds exhibited significantly less inflammation than control folds (P < 0.005). In addition, hypertrophy of the lamina propria and fibrosis were significantly reduced upon ASC injection (P < 0.02). The decrease in viscoelastic parameters was less important in the ASC injected group compared to the noninjected group (P = 0.08).
  
  
  
  Injection of autologous ASCs improved vocal fold healing in our preclinical model. Further studies are needed, but this method may be useful in humans.
  
  
  
  NA. Laryngoscope, 126:E278-E285, 2016.
authors.affiliation: CNRS UMR5273 STROMALab, University of Toulouse, Toulouse Cedex, France.|Université Paul Sabatier de Toulouse, University of Toulouse, Toulouse Cedex, France.|Department of Ear, Nose and Throat Head and Neck Surgery, University of Toulouse, Toulouse Cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: de Bonnecaze
authors.affiliation: CNRS UMR5273 STROMALab, University of Toulouse, Toulouse Cedex, France.|Université Paul Sabatier de Toulouse, University of Toulouse, Toulouse Cedex, France.|INSERM U1031, University of Toulouse, Toulouse Cedex, France.|EFS Pyrénées-Méditerranée, University of Toulouse, Toulouse Cedex, France.|Department of Plastic Reconstructive and Aesthetic Surgery, University of Toulouse, Toulouse Cedex, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Chaput
authors.affiliation: Department of Ear, Nose and Throat Head and Neck Surgery, University of Toulouse, Toulouse Cedex, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Woisard
authors.affiliation: Department of Cytopathology, University of Toulouse, Toulouse Cedex, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Uro-Coste
authors.affiliation: Biomechanics Group, IMFT UMR CNRS 5502, Toulouse Cedex, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Swider
authors.affiliation: Department of Ear, Nose and Throat Head and Neck Surgery, University of Toulouse, Toulouse Cedex, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Vergez
authors.affiliation: Department of Ear, Nose and Throat Head and Neck Surgery, University of Toulouse, Toulouse Cedex, France.
authors.forename: Elie
authors.initials: E
authors.lastname: Serrano
authors.affiliation: CNRS UMR5273 STROMALab, University of Toulouse, Toulouse Cedex, France.|Université Paul Sabatier de Toulouse, University of Toulouse, Toulouse Cedex, France.|INSERM U1031, University of Toulouse, Toulouse Cedex, France.|EFS Pyrénées-Méditerranée, University of Toulouse, Toulouse Cedex, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Casteilla
authors.affiliation: CNRS UMR5273 STROMALab, University of Toulouse, Toulouse Cedex, France.|Université Paul Sabatier de Toulouse, University of Toulouse, Toulouse Cedex, France.|INSERM U1031, University of Toulouse, Toulouse Cedex, France.|EFS Pyrénées-Méditerranée, University of Toulouse, Toulouse Cedex, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Planat-Benard
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000601:surgery*; D007818:Laryngeal Diseases / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D011817:Rabbits; D017154:Stromal Cells / Q000637:transplantation*; D014827:Vocal Cords
keywords: Wound healing; adipose stromal cells; biomechanical analysis; cytotherapy; vocal fold scar