title: Local Allergic Rhinitis.
abstract: This review focuses on local allergic rhinitis, a new phenotype of allergic rhinitis, commonly misdiagnosed as nonallergic rhinitis. It has gained attention over last decade and can affect patients from all countries, ethnic groups and ages, impairing their quality of life, and is frequently associated with conjunctivitis and asthma. Diagnosis is based on clinical history, the demonstration of a positive response to nasal allergen provocation test and/or the detection of nasal sIgE. A positive basophil activation test may support the diagnosis. Recent studies have demonstrated that allergen immunotherapy is an effective immune-modifying treatment, highlighting the importance of early diagnosis.
authors.affiliation: Regional University Hospital of Malaga, Plaza Hospital Civil s/n pabellon 6, Málaga 29009, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Campo
authors.affiliation: Regional University Hospital of Malaga, Plaza Hospital Civil s/n pabellon 6, Málaga 29009, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Salas
authors.affiliation: Allergy Service, Hospital Infanta Leonor, Gran Vía del Este, 80, Madrid 28031, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Blanca-López
authors.affiliation: Regional University Hospital of Malaga, Plaza Hospital Civil s/n pabellon 6, Málaga 29009, Spain. Electronic address: carmenrs61@gmail.com.
authors.forename: Carmen
authors.initials: C
authors.lastname: Rondón
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000276:immunology; D065631:Rhinitis, Allergic / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy
chemical_list: D007073:Immunoglobulin E
keywords: Allergen immunotherapy; Asthma; Local IgE; Local allergic rhinitis; Nasal allergen provocation test; Natural evolution