title: Reverse Vaccinology: The Pathway from Genomes and Epitope Predictions to Tailored Recombinant Vaccines.
abstract: In this chapter, we review the computational approaches that have led to a new generation of vaccines in recent years. There are many alternative routes to develop vaccines based on the technology of reverse vaccinology. We focus here on bacterial infectious diseases, describing the general workflow from bioinformatic predictions of antigens and epitopes down to examples where such predictions have been used successfully for vaccine development.
authors.affiliation: Department of Biosciences, University of Oslo, 0371, Oslo, Norway.|Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076, Tübingen, Germany.
authors.forename: Marcin
authors.initials: M
authors.lastname: Michalik
authors.affiliation: Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076, Tübingen, Germany.|Department for Applied Bioinformatics, Goethe-University, 60438, Frankfurt, Germany.
authors.forename: Bardya
authors.initials: B
authors.lastname: Djahanshiri
authors.affiliation: Department of Biosciences, University of Oslo, 0371, Oslo, Norway.
authors.forename: Jack C
authors.initials: JC
authors.lastname: Leo
authors.affiliation: Department of Biosciences, University of Oslo, 0371, Oslo, Norway. dirk.linke@ibv.uio.no.|Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076, Tübingen, Germany. dirk.linke@ibv.uio.no.
authors.forename: Dirk
authors.initials: D
authors.lastname: Linke
mesh_terms: D000818:Animals; D019295:Computational Biology; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D008285:Major Histocompatibility Complex; D022223:Vaccines, Subunit / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology*
chemical_list: D000939:Epitopes; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic