title: Antibacterial Applications of Nanodiamonds.
abstract: Bacterial infectious diseases, sharing clinical characteristics such as chronic inflammation and tissue damage, pose a major threat to human health. The steady increase of multidrug-resistant bacteria infections adds up to the current problems modern healthcare is facing. The treatment of bacterial infections with multi-resistant germs is very difficult, as the development of new antimicrobial drugs is hardly catching up with the development of antibiotic resistant pathogens. These and other considerations have generated an increased interest in the development of viable alternatives to antibiotics. A promising strategy is the use of nanomaterials with antibacterial character and of nanostructures displaying anti-adhesive activity against biofilms. Glycan-modified nanodiamonds (NDs) revealed themselves to be of great promise as useful nanostructures for combating microbial infections. This review summarizes the current efforts in the synthesis of glycan-modified ND particles and evaluation of their antibacterial and anti-biofilm activities.
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, University Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq Cedex, France. sabine.szunerits@univ.lille1.fr.
authors.forename: Sabine
authors.initials: S
authors.lastname: Szunerits
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, University Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq Cedex, France. alexandre.barras@iri.univ.lille1.fr.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Barras
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, University Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq Cedex, France. rabah.boukherroub@univ.lille1.fr.
authors.forename: Rabah
authors.initials: R
authors.lastname: Boukherroub
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001424:Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D058612:Nanodiamonds / Q000737:chemistry / Q000627:therapeutic use*; D011134:Polysaccharides / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D058612:Nanodiamonds; D011134:Polysaccharides
keywords: antimicrobial activity; biofilm inhibition; glycans; nanodiamonds