title: Synthesis and in vitro evaluation of novel triazine analogues as anticancer agents and their interaction studies with bovine serum albumin.
abstract: A novel series of triazine-benzimidazole analogs has been designed and synthesized for their in vitro anticancer activities. Four compounds (6, 16, 17 and 20) were identified as highly potent anticancer agents against 60 human cancer cell lines with GI50 in the nanomolar range. To improve the drug applications toward cancer cells, there is a need to couple these compounds to some carrier macromolecules. Following this approach, the interaction between triazine-benzimidazole analogues and bovine serum albumin (BSA) has been investigated with UV-Visible and fluorescence spectroscopic methods under physiological conditions. The observed fluorescence quenching indicates that these compounds could efficiently bind with BSA and be transported to the target site.
authors.affiliation: School of Chemistry and Biochemistry, Thapar University, Patiala 147 004, India.
authors.forename: Prinka
authors.initials: P
authors.lastname: Singla
authors.affiliation: School of Chemistry and Biochemistry, Thapar University, Patiala 147 004, India. Electronic address: vluxami@thapar.edu.
authors.forename: Vijay
authors.initials: V
authors.lastname: Luxami
authors.affiliation: School of Chemistry and Biochemistry, Thapar University, Patiala 147 004, India. Electronic address: kpaul@thapar.edu.
authors.forename: Kamaldeep
authors.initials: K
authors.lastname: Paul
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013053:Spectrophotometry; D014227:Triazines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D014227:Triazines; D012710:Serum Albumin, Bovine
keywords: Antitumor activity; Benzimidazole; Bovine serum albumin; Fluorescence resonance energy transfer; Triazine