title: Pre-Incubation of Auric Acid with DNA Is Unnecessary for the Formation of DNA-Templated Gold Nanoclusters.
abstract: The rationale for the preparation of DNA-templated gold nanoclusters (DNA-Au NCs) has not been well understood, thereby slowing down the advancement of the synthesis and applications of DNA-Au NCs. The interaction between metal ions and the DNA template seems to be the key factor for the successful preparation of DNA-templated metal nanoclusters. With the help of circular dichroism in this contribution, we put efforts into interrogating the necessity of pre-incubation of HAuCl4 with poly-adenine template in the formation of Au NCs by citrate reduction. Our results revealed that the pre-incubation of HAuCl4 with poly-adenine is not favorable for the formation of Au NCs, which is distinctly different from the formation process for silver nanoclusters. It is our hope that this study can provide guidance in the preparation of Au NCs with more DNA templates.
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Tao
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
authors.forename: Ruoyun
authors.initials: R
authors.lastname: Lin
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Pei
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. lina@pku.edu.cn.
authors.forename: Na
authors.initials: N
authors.lastname: Li
mesh_terms: D000241:Adenosine / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry*; D019343:Citric Acid / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D017612:Gold Compounds / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D002712:Chlorides; D017612:Gold Compounds; D019343:Citric Acid; D006046:Gold; C024568:gold tetrachloride, acid; D004247:DNA; D000241:Adenosine
keywords: DNA; citrate reduction; fluorescence; gold nanoclusters; poly-adenine