title: Arrive: A retrospective registry of Indian patients with venous thromboembolism.
abstract: OBJECTIVE
  There is lack of substantial Indian data on venous thromboembolism (VTE). The aim of this study was to provide real-world information on patient characteristics, management strategies, clinical outcomes, and temporal trends in VTE.
  
  
  METHODS
  Multicentre retrospective registry involving 549 medical records of patients with confirmed diagnosis of VTE (deep vein thrombosis [DVT] confirmed by Doppler ultrasonography; pulmonary embolism [PE] by computed tomography, pulmonary angiography and/or V/Q scan) from 2006 to 2010 at three Indian tertiary care hospitals.
  
  
  RESULTS
  Acute DVT without PE, acute DVT with PE, and PE alone were reported in 64% (352/549), 23% (124/549), and 13% (73/549) patients, respectively. Mean age was 47 (±16) years, and 70% were males. H/o DVT (34%), surgery including orthopedic surgery (28%), trauma (16%), and immobilization >3 days (14%) were the most common risk factors for VTE. Hypertension (25%), diabetes (19%), and neurological disease (other than stroke) (8%) were the most common co-morbidities. Most (94%) were treated with heparin alone (82%) or fondaparinux (2%) for initial anticoagulation; low molecular weight heparin alone (5%) or warfarin/acenocoumarol (76%) for long-term anticoagulation. Anticoagulant treatment was stopped because of bleeding in 2% (9/515) patients. Mortality was 7% among patients diagnosed with VTE during hospital stay versus 1% in those hospitalized with diagnosed VTE. The annual incidence of DVT (±PE) increased from 2006 to 2010.
  
  
  CONCLUSIONS
  Acute DVT alone was responsible for the substantial burden of VTE in Indian patients. Bleeding was not the limiting factor for anticoagulant treatment in most patients.
authors.affiliation: Department of Vascular Surgery, Ruby Hall Clinic, Pune, Maharashtra, India.
authors.forename: Dhanesh R
authors.initials: DR
authors.lastname: Kamerkar
authors.affiliation: Department of Clinical Haematology, Haemato-Oncology and Bone Marrow (Stem Cell) Transplant Unit, Christian Medical College, Ludhiana, Punjab, India.
authors.forename: M Joseph
authors.initials: MJ
authors.lastname: John
authors.affiliation: Department of Vascular and Endovascular Surgery, M S Ramaiah Hospital, Bengaluru, Karnataka, India.
authors.forename: Sanjay C
authors.initials: SC
authors.lastname: Desai
authors.affiliation: Area Medical Lead (Respiratory), GlaxoSmithKline Pharmaceuticals, Singapore.
authors.forename: Liesel C
authors.initials: LC
authors.lastname: Dsilva
authors.affiliation: Ex-Area Medical Head, Developing Countries- Asia, GlaxoSmithKline Pharmaceuticals, Mumbai, Maharashtra, India.
authors.forename: Sadhna J
authors.initials: SJ
authors.lastname: Joglekar
keywords: Anticoagulants; deep vein thrombosis; pulmonary embolism; retrospective registry; venous thromboembolism