title: Finding a place in the SUN: telomere maintenance in a diverse nuclear landscape.
abstract: Telomeres function in the context of a complex nuclear milieu in which telomeres tend to occupy distinct subnuclear regions. Indeed, regulation of the subnuclear positioning of telomeres is conserved from yeast to human, raising the age-old question: to what extent is location important for function? In mitotically dividing cells, the positioning of telomeres affects their epigenetic state and influences telomere processing and synthesis. In meiotic cells, telomere location is important for homologue pairing, centromere assembly and spindle formation. Here we focus on recent insights into the functions of telomere positioning in maintaining genome integrity.
authors.affiliation: Telomere Biology Section, LBMB, NCI, NIH, Bethesda, MD 20892, USA.
authors.forename: Hani
authors.initials: H
authors.lastname: Ebrahimi
authors.affiliation: Telomere Biology Section, LBMB, NCI, NIH, Bethesda, MD 20892, USA. Electronic address: julie.cooper@nih.gov.
authors.forename: Julia Promisel
authors.initials: JP
authors.lastname: Cooper
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry* / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism; D005057:Eukaryotic Cells / Q000145:classification / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism; D016615:Telomere / Q000378:metabolism*