title: Effect of Light Scattering and Higher-order Aberrations on Visual Performance in Eyes with Granular Corneal Dystrophy.
abstract: This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients who diagnosed GCD, and age-matched 20 eyes of 20 healthy subjects. We assessed objective scattering index (OSI) using the double-pass instrument (OQAS II, Visiometrics), corneal densitometry (CD) using the Scheimpflug rotating camera (Pentacam HR, Oculus), and corneal HOAs using the Hartmann-Shack aberrometry (KR-9000, Topcon). The OSI, CD, and corneal HOAs were significantly larger in the GCD group than those in the control group (Mann-Whitney U test, p < 0.001). We found significant correlations of logMAR CDVA with the OSI (Spearman correlation coefficient r = 0.577, p < 0.001), and with the CD (r = 0.340, p = 0.028), but no significant association with corneal HOAs (r = 0.061, p = 0.701). Intraocular forward scattering, corneal backward scattering, and corneal HOAs in eyes with GCD were higher than that in normal eyes. The CDVA was significantly correlated with intraocular forward scattering, but not with corneal HOAs in eyes with GCD, suggesting that light scattering, especially forward scattering, plays a more vital role in visual performance than corneal aberrations in eyes with GCD.
authors.affiliation: Department of Ophthalmology, University of Kitasato School of Medicine, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kamiya
authors.affiliation: Department of Ophthalmology, University of Kitasato School of Medicine, Japan.
authors.forename: Hidenaga
authors.initials: H
authors.lastname: Kobashi
authors.affiliation: Department of Ophthalmology, University of Kitasato School of Medicine, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Igarashi
authors.affiliation: Kitasato University School of Allied Health Sciences, Kanagawa, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shoji
authors.affiliation: Department of Ophthalmology, University of Kitasato School of Medicine, Japan.
authors.forename: Kimiya
authors.initials: K
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003315:Cornea / Q000473:pathology / Q000528:radiation effects; D003317:Corneal Dystrophies, Hereditary / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D012542:Scattering, Radiation; D041623:Tomography, Optical Coherence; D014792:Visual Acuity