title: Assessing the Firing Properties of the Electrically Stimulated Auditory Nerve Using a Convolution Model.
abstract: The electrically evoked compound action potential (eCAP) is a routinely performed measure of the auditory nerve in cochlear implant users. Using a convolution model of the eCAP, additional information about the neural firing properties can be obtained, which may provide relevant information about the health of the auditory nerve. In this study, guinea pigs with various degrees of nerve degeneration were used to directly relate firing properties to nerve histology. The same convolution model was applied on human eCAPs to examine similarities and ultimately to examine its clinical applicability. For most eCAPs, the estimated nerve firing probability was bimodal and could be parameterised by two Gaussian distributions with an average latency difference of 0.4 ms. The ratio of the scaling factors of the late and early component increased with neural degeneration in the guinea pig. This ratio decreased with stimulation intensity in humans. The latency of the early component decreased with neural degeneration in the guinea pig. Indirectly, this was observed in humans as well, assuming that the cochlear base exhibits more neural degeneration than the apex. Differences between guinea pigs and humans were observed, among other parameters, in the width of the early component: very robust in guinea pig, and dependent on stimulation intensity and cochlear region in humans. We conclude that the deconvolution of the eCAP is a valuable addition to existing analyses, in particular as it reveals two separate firing components in the auditory nerve.
authors.affiliation: R&D MED-EL GmbH, Innsbruck, Austria. stefan.strahl@medel.com.
authors.forename: Stefan B
authors.initials: SB
authors.lastname: Strahl
authors.affiliation: Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Dyan
authors.initials: D
authors.lastname: Ramekers
authors.affiliation: Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Marjolijn M B
authors.initials: MMB
authors.lastname: Nagelkerke
authors.affiliation: R&D MED-EL GmbH, Innsbruck, Austria.
authors.forename: Konrad E
authors.initials: KE
authors.lastname: Schwarz
authors.affiliation: R&D MED-EL GmbH, Innsbruck, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Spitzer
authors.affiliation: Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Sjaak F L
authors.initials: SFL
authors.lastname: Klis
authors.affiliation: Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Wilko
authors.initials: W
authors.lastname: Grolman
authors.affiliation: Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Huib
authors.initials: H
authors.lastname: Versnel
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003054:Cochlear Implants; D003056:Cochlear Nerve / Q000502:physiology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D006801:Humans
keywords: Auditory nerve; Cochlear implant; Deconvolution; Firing probability; Neural health; eCAP