title: [Meningioma: management of the most common brain tumour].
abstract: Meningiomas are the most common primary brain tumours in adults and are therefore relevant for general practitioners. Most meningiomas are benign and neurosurgical resection offers the best chance of cure. However, complete resection is not achievable in many patients. This accounts for a relevant rate of tumour recurrences within 15 years of follow up. In atypical and anaplastic meningiomas of WHO grade II and III time to recurrence is dramatically shorter and these tumours need multimodal treatment strategies including postoperative radiotherapy. Various systemic treatments have occasionally been used as salvage therapy, but were essentially not effective. Only recently, Sunitinib, a small thyrosine kinase inhibitor as well as bevacizumab, a therapeutic antibody, have shown more promising results in highly pretreated, refractory meningioma patients.
authors.affiliation: 1 Klinik für Neurologie, Kantonsspital St. Gallen.|2 Klinik für Hämatologie und Onkologie, Kantonsspital St. Gallen.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hundsberger
authors.affiliation: 3 Klinik für Neurochirurgie, Kantonsspital St. Gallen.
authors.forename: Werner
authors.initials: W
authors.lastname: Surbeck
authors.affiliation: 4 Klinik für Radiologie und Nuklearmedizin, Kantonsspital St. Gallen.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hader
authors.affiliation: 5 Klinik für Radioonkologie, Kantonsspital St. Gallen.
authors.forename: Paul Martin
authors.initials: PM
authors.lastname: Putora
authors.affiliation: 6 Klinik für Onkologie, Universitätsspital Basel.
authors.forename: Katrin
authors.initials: K
authors.lastname: Conen
authors.affiliation: 7 Neurologische Klinik und Hirntumorzentrum, Kantonsspital Aarau.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Roelcke
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D058006:General Practice; D006801:Humans; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D011379:Prognosis
keywords: Bevacizumab; Meningeome; Strahlentherapie; Sunitinib; Thrombosen; bevacizumab; meningioma; méningiome; radiotherapy; radiothérapie; sunitinib; thrombose; thrombosis