title: Effect of Beverage Containing Fermented Akebia quinata Extracts on Alcoholic Hangover.
abstract: The present study was conducted to investigate the effects of beverages containing fermented Akebia quinata extracts on alcoholic hangover. For this study, 25 healthy young men were recruited. All participants consumed 100 mL of water (placebo), commercial hangover beverage A or B, fermented A. quinata leaf (AQL) or fruit (AQF) extract before alcohol consumption. After 1 h, all participants consumed a bottle of Soju, Korean distilled liquor (360 mL), containing 20% alcohol. Blood was collected at 0 h, 1 h, 3 h, and 5 h after alcohol consumption. The plasma alanine transaminase (ALT) activity was highest in the placebo group. Compared with the control group, the AQL and AQF groups showed decreased ALT activity at 5 h after alcohol consumption. Plasma ethanol concentration was increased after alcohol intake and peaked at 3 h after alcohol consumption. Compared with the control group, the A group showed a higher plasma ethanol concentration at 1 h (P<0.05). At 3 h after alcohol consumption, the AQF group showed the lowest mean plasma ethanol concentration compared to the other groups; however, there were no statistical differences. After 5 h of alcohol consumption, the AQL and AQF groups showed lower plasma ethanol concentrations compared with the B group. The sensory evaluation score for the fermented A. quinata fruit extract was lower than for the commercial hangover beverages. In conclusion, the present intervention study results suggest that fermented A. quinata extracts alleviate alcoholic hangover and reduce plasma ethanol concentrations.
authors.affiliation: Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
authors.forename: Suhan
authors.initials: S
authors.lastname: Jung
authors.affiliation: Departement of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Departement of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Song
authors.affiliation: Departement of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Seo Yeon
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Departement of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul 03760, Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Departement of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Kwang Suk
authors.initials: KS
authors.lastname: Ko
keywords: Akebia quinata; alcohol; beverage; hangover; hepatoprotection