title: Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children's Study (JECS).
abstract: OBJECTIVE
  The aim of the study was to clarify the prevalence and determinants of inadequate use of folic acid supplementation in pregnant Japanese women.
  
  
  METHODS
  This study was part of the Japan Environment and Children's Study, a nationwide and government-funded birth cohort study. We collected information on the use of folic acid supplementation before and during pregnancy and characteristics of participants using self-administered questionnaire.
  
  
  RESULTS
  Among 9849 women who completed the data collection for this study, the prevalence of inadequate users was 92.6% of the total population and varied from 84.5% to 96.2% among regions. On the basis of multivariate logistic regression analysis, younger age, not married, lower family income, multipara, natural conception and no history of spontaneous abortion were found to be determinants for inadequate users of folic acid supplementation.
  
  
  CONCLUSIONS
  Most Japanese pregnant women show inadequate folic acid supplementation use. Japanese women of child-bearing age need to be specifically informed about the need for periconceptional intake of folic acid to prevent neural tube defects.
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|b Department of Pharmaceutical Sciences , Tohoku University Hospital , Aoba-ku, Sendai, Miyagi , Japan.|c Tohoku University Tohoku Medical Megabank Organization , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Obara
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|d Department of Gynecology and Obstetrics , and.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishigori
authors.affiliation: c Tohoku University Tohoku Medical Megabank Organization , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Toshie
authors.initials: T
authors.lastname: Nishigori
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|c Tohoku University Tohoku Medical Megabank Organization , Aoba-ku, Sendai, Miyagi , Japan.|d Department of Gynecology and Obstetrics , and.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Metoki
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|c Tohoku University Tohoku Medical Megabank Organization , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Ishikuro
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tatsuta
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuno
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Kasumi
authors.initials: K
authors.lastname: Sakurai
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|c Tohoku University Tohoku Medical Megabank Organization , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Ichiko
authors.initials: I
authors.lastname: Nishijima
authors.affiliation: b Department of Pharmaceutical Sciences , Tohoku University Hospital , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Murai
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|e Department of Pediatrics , Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan , and.
authors.forename: Ikuma
authors.initials: I
authors.lastname: Fujiwara
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Arima
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Nakai
authors.affiliation: b Department of Pharmaceutical Sciences , Tohoku University Hospital , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Nariyasu
authors.initials: N
authors.lastname: Mano
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|c Tohoku University Tohoku Medical Megabank Organization , Aoba-ku, Sendai, Miyagi , Japan.|d Department of Gynecology and Obstetrics , and.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.affiliation: a Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Aoba-ku, Sendai, Miyagi , Japan.|c Tohoku University Tohoku Medical Megabank Organization , Aoba-ku, Sendai, Miyagi , Japan.|f Tohoku University International Research Institute for Disaster Science , Aoba-ku, Sendai, Miyagi , Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D015331:Cohort Studies; D019587:Dietary Supplements / Q000706:statistics & numerical data*; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D015438:Health Behavior; D006801:Humans; D007564:Japan; D016015:Logistic Models; D009436:Neural Tube Defects / Q000517:prevention & control; D011247:Pregnancy; D037841:Pregnant People; D011295:Prenatal Care / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D005492:Folic Acid
keywords: Folic acid supplement; neural tube defects; pregnancy