title: Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity.
abstract: Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure-activity relationship studies reported to date.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, October University for Modern Science and Arts (MSA), Cairo, Egypt.
authors.forename: Aliya M S
authors.initials: AM
authors.lastname: El Newahie
authors.affiliation: Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Department of Pharmaceutical Chemistry, Future University, Cairo, Egypt.
authors.forename: Nasser S M
authors.initials: NS
authors.lastname: Ismail
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ain Shams University, Abbassia, Cairo, Egypt.
authors.forename: Dalal A
authors.initials: DA
authors.lastname: Abou El Ella
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ain Shams University, Abbassia, Cairo, Egypt.
authors.forename: Khaled A M
authors.initials: KA
authors.lastname: Abouzid
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011810:Quinoxalines; D011505:Protein-Tyrosine Kinases
keywords: Anticancer; Kinase inhibitors; Quinoxalines; SAR; Synthetic strategies