title: Relevance of defensin β-2 and α defensins (HNP1-3) in Alzheimer's disease.
abstract: The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β-2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined. Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.
authors.affiliation: Department of Medical Microbiology and Immunobiology University of Szeged, Dom ter 10, Szeged 6725, Hungary.
authors.forename: Martha
authors.initials: M
authors.lastname: Szekeres
authors.affiliation: Department of Psychiatry Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Kálvária Ave 57, Szeged 6724, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Ivitz
authors.affiliation: Department of Psychiatry Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Kálvária Ave 57, Szeged 6724, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Datki
authors.affiliation: Department of Psychiatry Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Kálvária Ave 57, Szeged 6724, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Kálmán
authors.affiliation: Department of Psychiatry Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Kálvária Ave 57, Szeged 6724, Hungary.
authors.forename: Magdolna
authors.initials: M
authors.lastname: Pákáski
authors.affiliation: Department of Psychiatry Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Kálvária Ave 57, Szeged 6724, Hungary.
authors.forename: Zoltán P
authors.initials: ZP
authors.lastname: Várhelyi
authors.affiliation: Department of Neurology Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Semmelweis u. 6, Szeged 6725 Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Klivényi
authors.affiliation: Department of Neurology Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Semmelweis u. 6, Szeged 6725 Hungary.
authors.forename: Dénes
authors.initials: D
authors.lastname: Zadori
authors.affiliation: Department of Medical Microbiology and Immunobiology University of Szeged, Dom ter 10, Szeged 6725, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Somogyvári
authors.affiliation: Department of Neurology and Cerebrovascular Diseases Pándy Kálmán County Hospital, Semmelweis u. 5, Gyula 5700 Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szolnoki
authors.affiliation: Department of Neurology Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Semmelweis u. 6, Szeged 6725 Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
authors.affiliation: Department of Medical Microbiology and Immunobiology University of Szeged, Dom ter 10, Szeged 6725, Hungary. Electronic address: mandi.yvette@med.u-szeged.hu.
authors.forename: Yvette
authors.initials: Y
authors.lastname: Mándi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D018628:Gene Dosage; D006801:Humans; D008297:Male; D023084:alpha-Defensins / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*; D023083:beta-Defensins / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*
chemical_list: C106641:DEFB4A protein, human; D023084:alpha-Defensins; D023083:beta-Defensins; C406413:human neutrophil peptide 1
keywords: Antimicrobial peptides; Cerebrospinal fluid; Copy number polymorphism