title: An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population.
abstract: Narcolepsy without cataplexy (NA w/o CA) (narcolepsy type 2) is a lifelong disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, but no cataplexy. In the present study, we examined the human leukocyte antigen HLA-DQB1 in 160 Japanese patients with NA w/o CA and 1,418 control subjects. Frequencies of DQB1*06:02 were significantly higher in patients with NA w/o CA compared with controls (allele frequency: 16.6 vs. 7.8%, P=1.1×10(-7), odds ratio (OR)=2.36; carrier frequency: 31.3 vs. 14.7%, P=7.6×10(-8), OR=2.64). Distributions of HLA-DQB1 alleles other than DQB1*06:02 were compared between NA w/o CA and narcolepsy with cataplexy (NA-CA) to assess whether the genetic backgrounds of the two diseases have similarities. The distribution of the HLA-DQB1 alleles in DQB1*06:02-negative NA w/o CA was significantly different from that in NA-CA (P=5.8×10(-7)). On the other hand, the patterns of the HLA-DQB1 alleles were similar between DQB1*06:02-positive NA w/o CA and NA-CA. HLA-DQB1 analysis was also performed in 186 Japanese patients with idiopathic hypersomnia (IHS) with/without long sleep time, but no significant associations were observed.
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Miyagawa
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Toyoda
authors.affiliation: Department of Neuropsychiatry, Akita University School of Medicine, Akita, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, Japan.
authors.forename: Takashi
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authors.lastname: Kanbayashi
authors.affiliation: Department of Neuropsychiatry, Akita University School of Medicine , Akita, Japan.
authors.forename: Aya
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authors.lastname: Imanishi
authors.affiliation: Department of Neuropsychiatry, Akita University School of Medicine , Akita, Japan.
authors.forename: Yohei
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authors.lastname: Sagawa
authors.affiliation: Department of Neuropsychiatry, Kurume University School of Medicine, Fukuoka, Japan; Kotorii Isahaya Hospital, Nagasaki, Japan.
authors.forename: Nozomu
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authors.lastname: Kotorii
authors.affiliation: Kotorii Isahaya Hospital , Nagasaki, Japan.
authors.forename: Tatayu
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authors.lastname: Kotorii
authors.affiliation: Department of Neuropsychiatry, Kurume University School of Medicine , Fukuoka, Japan.
authors.forename: Yuji
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authors.lastname: Hashizume
authors.affiliation: Department of Neuropsychiatry, Kurume University School of Medicine , Fukuoka, Japan.
authors.forename: Kimihiro
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authors.lastname: Ogi
authors.affiliation: Department of Neuropsychiatry, Kurume University School of Medicine , Fukuoka, Japan.
authors.forename: Hiroshi
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authors.lastname: Hiejima
authors.affiliation: Sleep Disorder Center, National Center Hospital, National Center of Neurology and Psychiatry , Tokyo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kamei
authors.affiliation: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry , Tokyo, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Hida
authors.affiliation: Department of Neurology, Dokkyo Medical University , Tochigi, Japan.
authors.forename: Masayuki
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authors.lastname: Miyamoto
authors.affiliation: Sleep Center, Kuwamizu Hospital , Kumamoto, Japan.
authors.forename: Azusa
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authors.lastname: Ikegami
authors.affiliation: Department of Psychiatry, Hannan Hospital , Osaka, Japan.
authors.forename: Yamato
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authors.lastname: Wada
authors.affiliation: Department of Psychiatry, Shiga University of Medical Science , Shiga, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Takami
authors.affiliation: Department of Psychiatry and Neurology, Asahikawa Medical University, Hokkaido, Japan; Department of General Medicine, Faculty of Medicine, Shimane University, Shimane, Japan.
authors.forename: Yota
authors.initials: Y
authors.lastname: Fujimura
authors.affiliation: Department of Psychiatry and Neurology, Asahikawa Medical University , Hokkaido, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui , Fukui, Japan.
authors.forename: Naoto
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authors.lastname: Omata
authors.affiliation: Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui , Fukui, Japan.
authors.forename: Yasuhiro
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authors.lastname: Masuya
authors.affiliation: Center for Sleep Medicine, Saiseikai Nagasaki Hospital , Nagasaki, Japan.
authors.forename: Hideaki
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authors.lastname: Kondo
authors.affiliation: Department of Psychiatry, Tokyo Women's Medical University School of Medicine , Tokyo, Japan.
authors.forename: Shunpei
authors.initials: S
authors.lastname: Moriya
authors.affiliation: Department of Neurology, Neuro-Muscular Center, National Omuta Hospital, Fukuoka, Japan; Department of Neurology, Kochi Medical School, Kochi University, Kochi, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Furuya
authors.affiliation: Department of Pediatrics, Yamagata University Faculty of Medicine, Yamagata, Japan; Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Mitsuhiro
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authors.lastname: Kato
authors.affiliation: HLA Foundation Laboratory , Kyoto, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kojima
authors.affiliation: Department of HLA Laboratory, Japanese Red Cross Kanto-Koshinetsu Block Blood Center , Tokyo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kashiwase
authors.affiliation: HLA Foundation Laboratory , Kyoto, Japan.
authors.forename: Hiroh
authors.initials: H
authors.lastname: Saji
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Seik-Soon
authors.initials: SS
authors.lastname: Khor
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Maria
authors.initials: M
authors.lastname: Yamasaki
authors.affiliation: Department of Psychiatry, Tokyo Women's Medical University School of Medicine , Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ishigooka
authors.affiliation: Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui , Fukui, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wada
authors.affiliation: Department of Psychiatry and Neurology, Asahikawa Medical University , Hokkaido, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Chiba
authors.affiliation: Department of Psychiatry, Shiga University of Medical Science , Shiga, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamada
authors.affiliation: Department of Sleep Medicine, Shiga University of Medical Science, Shiga, Japan; Japan Foundation for Neuroscience and Mental Health, Tokyo, Japan; Department of Somnology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Okawa
authors.affiliation: Department of Psychiatry, Hannan Hospital , Osaka, Japan.
authors.forename: Kenji
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authors.lastname: Kuroda
authors.affiliation: Sleep Center, Kuwamizu Hospital, Kumamoto, Japan; Department of Stem Cell Biology, Institute of Molecular Genetics and Embryology, Kumamoto University, Kumamoto, Japan; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi, Japan.
authors.forename: Kazuhiko
authors.initials: K
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authors.affiliation: Department of Neurology, Dokkyo Medical University , Tochigi, Japan.
authors.forename: Koichi
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authors.affiliation: Department of Neuropsychiatry, Kurume University School of Medicine , Fukuoka, Japan.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Uchimura
authors.affiliation: Department of Neuropsychiatry, Akita University School of Medicine, Akita, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, Japan.
authors.forename: Tetsuo
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authors.lastname: Shimizu
authors.affiliation: Department of Somnology, Tokyo Medical University, Tokyo, Japan; Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Japan Somnology Center, Neuropsychiatric Research Institute , Tokyo, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Honda
authors.affiliation: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry , Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mishima
authors.affiliation: Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan; Sleep Disorders Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
authors.forename: Makoto
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authors.lastname: Honda
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
authors.forename: Katsushi
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