title: Neurorestorative effects of epigallocatechin-3-Gallate on cognitive function in a chronic cerebral hypoperfusion rat model.
abstract: This study investigated whether (-)-epigallocatechin-3-gallate (EGCG) can enhance cognition by a neurorestorative effect in a rat model of bilateral common carotid artery occlusion (BCCAO).
  
  
  
  Forty-eight male, 8-week-old Sprague-Dawley rats were randomly allocated to four groups 6 weeks after BCCAO or sham operation: EGCG-single intravenous injection (25 mg/kg/day; SIV group), EGCG-multiple intraperitoneal injection (50 mg/kg/day for 5 days; MIP group), untreated BCCAO group (untreated group), and sham-operated group (sham group).
  
  
  
  Escape latency was significantly shorter in the SIV and MIP groups than in the untreated group. SIV and MIP groups were significantly different from the untreated group in the activity of superoxide dismutase and the content of malondialdehyde (p < 0.05). Protein expression level of brain-derived neurotrophic factor was not significantly different between groups (p > 0.05), while protein expression of vascular endothelial growth factor was significantly lower in the SIV group than in the untreated group (p < 0.05). Protein expression of N-methyl-D-aspartate receptor subunits NR1 and NR2B was significantly higher in the MIP group than in the untreated group (p < 0.05).
  
  
  
  EGCG administration at 6 weeks after BCCAO is neurorestorative via an anti-oxidant effect and synaptogenesis, except for angiogenesis.
authors.affiliation: Department of Physical & Rehabilitation Medicine, Chonnam National University Medical School & Hospital, Gwangju City, Republic of Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Han
authors.affiliation: Department of Rehabilitation Standard & Policy, National Rehabilitation Center Research Institute, Seoul City, Republic of Korea.
authors.forename: Jung-Kook
authors.initials: JK
authors.lastname: Kim
authors.affiliation: Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-Shin University, Naju City, Republic of Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Sports and Leisure Science, Sunchon National University, Sunchon City, Republic of Korea.
authors.forename: Bong-Seok
authors.initials: BS
authors.lastname: Oh
authors.affiliation: Department of Physical Education, Chosun University, Gwangju City, Republic of Korea.
authors.forename: Wan-Ju
authors.initials: WJ
authors.lastname: Cho
authors.affiliation: Department of Biochemistry, Chonnam National University Medical School, Gwangju City, Republic of Korea.
authors.forename: Young Do
authors.initials: YD
authors.lastname: Jung
authors.affiliation: Department of Physical & Rehabilitation Medicine, Chonnam National University Medical School & Hospital, Gwangju City, Republic of Korea.
authors.forename: Sam-Gyu
authors.initials: SG
authors.lastname: Lee
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002561:Cerebrovascular Disorders / Q000150:complications*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology*; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D004924:Escape Reaction / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D017966:Pyramidal Cells / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C409466:NR1 NMDA receptor; C121001:NR2B NMDA receptor; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; D042461:Vascular Endothelial Growth Factor A; D008315:Malondialdehyde; D002392:Catechin; C045651:epigallocatechin gallate; D013482:Superoxide Dismutase
keywords: (–)-Epigallocatechin-3-Gallate; cognition; neurorestoration; rat; vascular dementia