title: Synthesis, characterization and biological evaluation of tryptamine based benzamide derivatives.
abstract: Benzamides and tryptamine are biologically significant compounds, therefore, various benzamide analogous of tryptamine have been efficiently synthesized using tryptamine and different benzoyl chlorides, in order to find new biologically active compounds. The resulting products were then characterized by melting point determination, calculation of Rf values and LC-MS techniques. At last, structure activity relationship (SAR) of the synthesized compounds was evaluated against two microbial strains; Bacillus subtilis and Aspergillus niger. All the five prepared products have shown high yield, sharp characterization and significant resistance against the growth of tested microorganism, providing a new range of tryptamine based benzamide derivatives having significant antimicrobial activities.
authors.affiliation: Department of Chemistry, Government College University, Faisalabad, Pakistan.
authors.forename: Kiran
authors.initials: K
authors.lastname: Aftab
authors.affiliation: Department of Chemistry, Government College University, Faisalabad, Pakistan.
authors.forename: Kinza
authors.initials: K
authors.lastname: Aslam
authors.affiliation: Department of Chemistry, Government College University, Faisalabad, Pakistan.
authors.forename: Shazia
authors.initials: S
authors.lastname: Kousar
authors.affiliation: Department of Chemistry, Government College University, Faisalabad, Pakistan.
authors.forename: Muhammad Jawad Ul Hasan
authors.initials: MJ
authors.lastname: Nadeem
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects / Q000254:growth & development; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001549:Benzamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D044366:Transition Temperature; D014363:Tryptamines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D001549:Benzamides; D014363:Tryptamines