title: Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats.
abstract: Depression is among the most prevalent and life-threatening forms of mental illness, and is also a risk factor for cardiovascular disorders, diabetes and metabolic syndrome. Elderly patients commonly receive statins for the prevention of cardiovascular diseases, and antidepressant drugs for the treatment of depression. It should be noted that long-term polypharmacotherapy may lead to potential drug interactions and disorders of the organs. The aim of the present study was to determine whether, and to what extent, combined treatment with rosuvastatin and antidepressants (amitriptyline or fluoxetine) influences the biochemical markers of liver and kidney function in a rat model. For this purpose, the activity levels of aspartate aminotransferase, alanine aminotransferase (ALT), γ-glutamyltransferase (GGT) and the concentrations of total protein, urea, creatinine and β2-microglobulin were determined. The results of the study indicated that combined treatment with rosuvastatin and the antidepressants amitriptyline and fluoxetine for 14 days altered the activity levels of ALT and GGT, and the concentrations of urea and creatinine in the serum compared with groups of rats receiving rosuvastatin or either antidepressant alone. These observed changes in biochemical parameters may suggest the possibility of impaired liver and kidney function during the continuous combined exposure to the drugs. However, further clinical and animal studies are required in order to further elucidate this process.
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin 20-093, Poland.
authors.forename: Mariola
authors.initials: M
authors.lastname: Herbet
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin 20-093, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Gawrońska-Grzywacz
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin 20-093, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Izdebska
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin 20-093, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Piątkowska-Chmiel
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin 20-093, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
keywords: amitriptyline; biochemical parameters; fluoxetine; kidney; liver; rosuvastatin