title: Poly(ADP-Ribose) Polymerases in Aging - Friend or Foe?
abstract: Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.
authors.forename: András
authors.initials: A
authors.lastname: Vida
authors.forename: Omar
authors.initials: O
authors.lastname: Abdul-Rahman
authors.forename: Edit
authors.initials: E
authors.lastname: Mikó
authors.forename: Attila
authors.initials: A
authors.lastname: Brunyánszki
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, H- 4032 Debrecen, Egyetem tér 1, Hungary. baip@med.unideb.hu.
authors.forename: Peter
authors.initials: P
authors.lastname: Bai
mesh_terms: D000375:Aging / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D002450:Cell Communication / Q000235:genetics / Q000276:immunology; D004789:Enzyme Activation; D044127:Epigenesis, Genetic; D015971:Gene Expression Regulation, Enzymologic; D042822:Genomic Instability; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D059748:Proteolysis; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000378:metabolism
chemical_list: D011065:Poly(ADP-ribose) Polymerases