title: Short sleep duration increases salivary IL-6 production.
abstract: Morning shift sleep restriction has been associated with higher plasma IL-6 levels. The aim of this study was to investigate the effect of sleep duration on salivary IL-6. Sleep duration of morning shift workers was estimated by actigraphy. Workers with "longer sleep duration" (LSD; N = 6) and "shorter sleep duration" (SSD; N = 15) were then compared regarding salivary IL-6 levels determined at 14:00 h, bed and wake times. SSD workers did not show daily variation of IL-6 and presented higher levels at bedtime and 14:00 h compared to LSD workers. In this study, SSD is associated with an increase in salivary IL-6 content.
authors.affiliation: a National Technical Center , Fundacentro, São Paulo , Brazil.
authors.forename: Érica Lui
authors.initials: ÉL
authors.lastname: Reinhardt
authors.affiliation: b Laboratory of Chronopharmacology, Department of Physiology , Institute of Bioscience, University of São Paulo , São Paulo , Brazil.
authors.forename: Pedro A C M
authors.initials: PA
authors.lastname: Fernandes
authors.affiliation: b Laboratory of Chronopharmacology, Department of Physiology , Institute of Bioscience, University of São Paulo , São Paulo , Brazil.
authors.forename: Regina P
authors.initials: RP
authors.lastname: Markus
authors.affiliation: c Department of Environmental Health, School of Public Health , University of São Paulo , São Paulo , Brazil.
authors.forename: Frida Marina
authors.initials: FM
authors.lastname: Fischer
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D015850:Interleukin-6 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism*; D012890:Sleep / Q000502:physiology*; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology*; D014940:Work Schedule Tolerance
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D006854:Hydrocortisone
keywords: Morning shifts; salivary IL-6; short sleep duration