title: Biomarkers and diagnostic tools for detection of Helicobacter pylori.
abstract: Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. H. pylori is associated with significant morbidity and mortality including gastric cancer. The infection has both direct and indirect impacts on economic and overall well-being of patients; hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits. Here, we briefly review general aspects of H. pylori infection and the diagnostic biomarkers used in laboratory tests today with a focus on the potential role of microfluidic systems in future immunodiagnosis platforms.
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Rm. 265, Cambridge, MA, 02139, USA.
authors.forename: Akbar
authors.initials: A
authors.lastname: Khalilpour
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Rm. 265, Cambridge, MA, 02139, USA.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Kazemzadeh-Narbat
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Rm. 265, Cambridge, MA, 02139, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Tamayol
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.|Division of Vascular and Interventional Radiology, Mayo Clinic, Scottsdale, AZ, 85259, USA.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Oklu
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA. alik@rics.bwh.harvard.edu.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Rm. 265, Cambridge, MA, 02139, USA. alik@rics.bwh.harvard.edu.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA. alik@rics.bwh.harvard.edu.|Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia. alik@rics.bwh.harvard.edu.|Department of Bioindustrial Technologies, Konkuk University, Seoul, South Korea. alik@rics.bwh.harvard.edu.
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D015415:Biomarkers / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D046210:Microfluidic Analytical Techniques
chemical_list: D015415:Biomarkers
keywords: Diagnostic kits; Helicobacter pylori; Infection markers; Microfluidic systems