title: Correlation between TH1 response standard cytokines as biomarkers in patients with the delta virus in the western Brazilian Amazon.
abstract: Hepatitis D virus (HDV) is endemic in the Amazon Region and its pathophysiology is the most severe among viral hepatitis. Treatment is performed with pegylated interferon and the immune response appears to be important for infection control. HDV patients were studied: untreated and polymerase chain reaction (PCR) positive (n = 9), anti-HDV positive and PCR negative (n = 8), and responders to treatment (n = 12). The cytokines, interleukin (IL)-2 (p = 0.0008) and IL-12 (p = 0.02) were differentially expressed among the groups and were also correlated (p = 0.0143). Future studies will be conducted with patients at different stages of treatment, associating the viral load with serum cytokines produced, thereby attempting to establish a prognostic indicator of the infection.
authors.affiliation: Universidade Federal de Rondônia, Porto Velho, RO, Brasil.
authors.forename: Larissa Deadame de Figueiredo
authors.initials: LD
authors.lastname: Nicolete
authors.affiliation: Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brasil.
authors.forename: Lourdes Maria Pinheiro
authors.initials: LM
authors.lastname: Borzacov
authors.affiliation: Universidade Federal de Rondônia, Porto Velho, RO, Brasil.
authors.forename: Deusilene Souza
authors.initials: DS
authors.lastname: Vieira
authors.affiliation: Universidade Federal de Rondônia, Porto Velho, RO, Brasil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Nicolete
authors.affiliation: Universidade Federal de Rondônia, Porto Velho, RO, Brasil.
authors.forename: Juan Miguel Villalobos
authors.initials: JM
authors.lastname: Salcedo
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005260:Female; D005838:Genotype; D003699:Hepatitis D / Q000188:drug therapy* / Q000821:virology; D003698:Hepatitis Delta Virus / Q000276:immunology*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D016133:Polymerase Chain Reaction; D012367:RNA, Viral; D011994:Recombinant Proteins / Q000627:therapeutic use; D018417:Th1 Cells / Q000276:immunology; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D016207:Cytokines; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a