title: Efficacy of Neo-Adjuvant Chemoradiotherapy for Resectable Pancreatic Adenocarcinoma: A PRISMA-Compliant Meta-Analysis and Systematic Review.
abstract: We have conducted a meta-analysis and systematic review to determine the overall survival, mortality rate, and complete resection rate of neo-adjuvant chemoradiotherapy (CRT) compared with pancreaticoduodenectomy alone in patients with pancreatic adenocarcinoma. Whether neo-adjuvant CRT is beneficial in the treatment of resectable pancreatic cancer or not, it is still a controversial issue. Medline and Cochrane were searched with relevant terms. Eight studies with a total of 833 participants were selected. The meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The analysis revealed neo-adjuvant group may have a benefit in the overall survival, as compared with the resection group, although it did not reach statistical significance (pooled hazard ratio = 0.87, 95% confidence interval [CI] = 0.75-1.00, P = 0.051). We found no difference in the in-hospital mortality rate (pooled odds ratio [OR] = 1.27, 95% CI = 0.35-4.58, P = 0.710). The complete resection rate was significantly higher in the neo-adjuvant group than in the resection group (pooled OR = 2.39, 95% CI = 1.21-4.74, P = 0.012). This meta-analysis found that there was no significant difference in the overall survival between patients treated with neo-adjuvant CRT or pancreaticduodenectomy.
authors.affiliation: From the Biliary-Pancreatic Surgery Department, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Xue-Liang
authors.initials: XL
authors.lastname: Fu
authors.forename: Jian-Yu
authors.initials: JY
authors.lastname: Yang
authors.forename: De-Jun
authors.initials: DJ
authors.lastname: Liu
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Zhang
authors.forename: Yan-Miao
authors.initials: YM
authors.lastname: Huo
authors.forename: Min-Wei
authors.initials: MW
authors.lastname: Yang
authors.forename: Rong
authors.initials: R
authors.lastname: Hua
authors.forename: Yong-Wei
authors.initials: YW
authors.lastname: Sun
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000628:therapy*; D016577:Pancreaticoduodenectomy / Q000401:mortality*; D016019:Survival Analysis