title: Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production.
abstract: Three new sesquiterpenoids, 2α-hydroxy-3,3,6α,9β-tetramethyltricyclo[4,3,2(1,4)]undecane (1), 11-acetoxyeudesman-4β-ol (4), and 2α,3β-dihydroxy-4β-methyl-6,8,10-cadinatriene (6), four known sesquiterpenoids (2, 3, 5, and 7), together with eight known diterpenoids (8-15), were isolated from the wood of Cunninghamia konishii. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. Four sesquiterpenoids (1, 4, 5, and 6) and all the diterpenoids (8-15) were evaluated for inhibition of nitric oxide production in lipopolysaccharides (LPS)-activated RAW 264.7 macrophages and the results showed that compounds 10 and 15 exhibited moderate inhibitory activities against nitric oxide production.
authors.affiliation: Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. changchii@mail.npust.edu.tw.
authors.forename: Chi-I
authors.initials: CI
authors.lastname: Chang
authors.affiliation: Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan. ccchen@sunrise.hk.edu.tw.
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan. cychao@asia.edu.tw.|Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. cychao@asia.edu.tw.
authors.forename: Che-Yi
authors.initials: CY
authors.lastname: Chao
authors.affiliation: Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan. taiwanfir@dragon.nchu.edu.tw.
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hschang@kmu.edu.tw.|Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hschang@kmu.edu.tw.
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.affiliation: Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.affiliation: School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. gjhuang@mail.cmu.edu.tw.
authors.forename: Guan-Jhong
authors.initials: GJ
authors.lastname: Huang
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan. r93223083@ntu.edu.tw.
authors.forename: Yen-Cheng
authors.initials: YC
authors.lastname: Li
authors.affiliation: School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. kuoyh@mail.cmu.edu.tw.|Department of Biotechnology, Asia University, Taichung 413, Taiwan. kuoyh@mail.cmu.edu.tw.
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000818:Animals; D032486:Cunninghamia / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000737:chemistry; D000067996:RAW 264.7 Cells; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014934:Wood / Q000737:chemistry
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes; D009569:Nitric Oxide
keywords: Chinese herb; Cunninghamia konishii; Taxodiaceae; cadinane; eudesmane; sesquiterpenoid