title: Effects of Cyclo-His-Pro-enriched yeast hydrolysate on blood glucose levels and lipid metabolism in obese diabetic ob/ob mice.
abstract: OBJECTIVE
  We examined the hypoglycemic and anti-hyperlipidemic effect of yeast hydrolysate (YH) enriched with Cyclo-His-Pro (CHP) in the C57BL/6J ob/ob mouse model.
  
  
  METHODS
  Mice were separated into 4 groups (8 mice/group) on the basis of blood glucose and body weight: WT control, lean mice given vehicle; ob/ob control, ob/ob mice given vehicle; YH-1, ob/ob mice given 0.5 g/kg of YH; YH-2, ob/ob mice given 1 g/kg of YH. YH in saline or vehicle was administered orally in the same volume every day for 3 weeks.
  
  
  RESULTS
  Mice treated with YH (0.5 and 1 g/kg) for 3 weeks displayed a significant reduction in overall body weight gain and perirenal and epididymal adipose tissue weight compared to the ob/ob control group. Additionally, high-density lipoprotein (HDL) cholesterol, glucose, and atherogenic indexes were significantly decreased in the blood of YH-1 and YH-2 groups compared to the ob/ob control. In ob/ob mice, YH administration significantly improved glucose tolerance and blood insulin levels. These data indicate that YH treatment produces potent hypoglycemic and anti-hyperlipidemic effects by controlling body weight, fat mass, blood lipid, insulin levels, and glucose tolerance.
  
  
  CONCLUSIONS
  YH could potentially be used as a treatment option for diabetes and hyperlipidemia. The CHP-enriched YH may be a promising strategy in the development of hypoglycemic peptide nutraceuticals.
authors.affiliation: Department of Home Economic Education, Jeonju University, Jeonju 55069, Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Jung
authors.affiliation: Department of Beauty Art, Suwon Women's University, Suwon 16632, Korea.
authors.forename: Yang Hee
authors.initials: YH
authors.lastname: Hong
authors.affiliation: LINC Project Group, Daejeon University, Daejeon 34520, Korea.
authors.forename: Chung
authors.initials: C
authors.lastname: Park
authors.affiliation: Department of Public Health Sciences, Graduate School, Korea University, 145 Anam-ro, Sungbuk-gu, Seoul 02841, Korea.
authors.forename: Hyung Joo
authors.initials: HJ
authors.lastname: Suh
keywords: Yeast hydrolysate; blood glucose; cyclo-his-pro; diabetes mellitus