title: Clinical Pearls: Leprosy Reactions.
abstract: Leprosy reactions are acute inflammatory episodes that occur in the setting of Mycobacterium leprae infection. Precipitants of reactions can be pharmacologic and nonpharmacologic. Both type 1 and type 2 reactions typically occur before and during leprosy treatment but may also occur after treatment has been completed. Reactions cause morbidity due to nerve damage, and prompt corticosteroid therapy is warranted to minimize nerve damage due to reactions.
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Jane
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON, Canada Public Health Ontario Laboratories, Public Health Ontario, Toronto, ON, Canada Tropical Disease Unit, Division of Infectious Diseases, University Health Network-Toronto General Hospital, Toronto, ON, Canada andrea.boggild@utoronto.ca.
authors.forename: Andrea K
authors.initials: AK
authors.lastname: Boggild
mesh_terms: D006801:Humans; D007249:Inflammation / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D007918:Leprosy / Q000150:complications* / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000209:etiology
keywords: Hansen’s disease; Mycobacterium leprae; erythema nodosum leprosum; immune reconstitution syndrome