title: HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy.
abstract: Around 15-30% of AIDS patients fail to recover their CD4(+) T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of <50 copies per ml were investigated. Viral load and CD4 T cells counts were performed following standard techniques. HLA genotyping was performed using PCR-SSP technique. The Statistical Package for Social Sciences (SPSS version 19) was used for data processing and analysis. A significantly higher proportion of poor immune responders were carrying HLA-A68 (4.8% compared to 25.0%, P=0.025) and HLA-B15 (2.4% compared to 20.8%, P=0.023). The etiological fraction (Efe%) among carriers of HLA-A68 was 57.89% (95% CI=26.79, 75.79) and was 61.35% (95% CI=35.33, 76.91) among carriers of HLA-B15.
authors.affiliation: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: marah.eltahir@yahoo.com.
authors.forename: Marah
authors.initials: M
authors.lastname: El-Beeli
authors.affiliation: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: samira.almahruqi@gmail.com.
authors.forename: Samira Hamad
authors.initials: SH
authors.lastname: Al-Mahrooqi
authors.affiliation: Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: rahman.randa@gmail.com.
authors.forename: Randa Mahmoud
authors.initials: RM
authors.lastname: Youssef
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: fahad.alzadjali@gmail.com.
authors.forename: Fahad
authors.initials: F
authors.lastname: Zadjali
authors.affiliation: Infection Control Unit, Department of Medicine, SQUH, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: balkhair2020@gmail.com.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Balkhair
authors.affiliation: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: albuloshi@hotmail.com.
authors.forename: Mohammed Said
authors.initials: MS
authors.lastname: Al-Balushi
authors.affiliation: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: esaid@squ.edu.om.
authors.forename: Elias Anthony
authors.initials: EA
authors.lastname: Said
authors.affiliation: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: shyahasson@squ.edu.om.
authors.forename: Sidgi Syed
authors.initials: SS
authors.lastname: Hasson
authors.affiliation: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: aaljabri@squ.edu.om.
authors.forename: Ali Abdullah
authors.initials: AA
authors.lastname: Al-Jabri
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology*; D000328:Adult; D000483:Alleles; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D015497:HIV-1; D015234:HLA-A Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen / Q000235:genetics*; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D015234:HLA-A Antigens; D059910:HLA-B15 Antigen
keywords: AIDS; HIV; HLA; Immune response; Oman; cART