title: Correlation of cystatin C and creatinine based estimates of renal function in children with hydronephrosis.
abstract: BACKGROUND
  The use of a simple and accurate glomerular filtration rate (GFR) estimating method aiming minute assessment of renal function can be of great clinical importance.
  
  
  OBJECTIVE
  This study aimed to determine the association of a GFR estimating by equation that includes only cystatin C (Gentian equation) to equation that include only creatinine (Schwartz equation) among children.
  
  
  METHODS
  A total of 31 children aged from 1 day to 5 years with the final diagnosis of unilateral or bilateral hydronephrosis referred to Besat hospital in Hamadan, between March 2010 and February 2011 were consecutively enrolled. Schwartz and Gentian equations were employed to determine GFR based on plasma creatinine and cystatin C levels, respectively.
  
  
  RESULTS
  The proportion of GFR based on Schwartz equation was 70.19± 24.86 ml/min/1.73 m(2), while the level of this parameter based on Gentian method and using cystatin C was 86.97 ± 21.57 ml/min/1.73 m(2). The Pearson correlation coefficient analysis showed a strong direct association between the two levels of GFR measured by Schwartz equation based on serum creatinine level and Gentian method and using cystatin C (r = 0.594, P < 0.001). The linear association between GFR values measured with the two methods included cystatin C based GFR = 50.8+ 0.515 × Schwartz GFR. The correlation between GFR values measured by using serum creatinine and serum cystatin C measurements remained meaningful even after adjustment for patients' gender and age (r = 0.724, P < 0.001).
  
  
  CONCLUSIONS
  The equation developed based on cystatin C level is comparable with another equation, based on serum creatinine (Schwartz formula) to estimate GFR in children.
authors.affiliation: Division of pediatric nephrology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Hossein-Emad
authors.initials: HE
authors.lastname: Momtaz
authors.affiliation: Department of Pathology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Dehghan
authors.affiliation: Department of Pathology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Karimian
keywords: Creatinine; Cystatin C; Hydronephrosis; Renal function