title: Clinical Evaluation of Macular Thickness Changes in Cataract Surgery Using a Light-Adjustable Intraocular Lens.
abstract: OBJECTIVE
  To detect changes in retinal perfusion and macular thickness using fluorescein angiography and spectral-domain optical coherence tomography (OCT) before and after implantation of a Calhoun light-adjustable intraocular lens (Calhoun Vision, Pasadena, CA) and application of profiled doses of ultraviolet light for postoperative refractive adjustments.
  
  
  METHODS
  This prospective trial of non-consecutive cases comprised 125 eyes of 125 patients who had cataract surgery and light-adjustable intraocular lens implantation. OCT examinations were performed preoperatively and postoperatively before first adjustment (10 to 14 days postoperatively) and 1 week (20 to 25 days postoperatively), 1 month (6 weeks postoperatively), 3 months (4 months postoperatively), and 12 months (13 months postoperatively) after lock-in. A control group of 104 eyes was evaluated for comparison.
  
  
  RESULTS
  One hundred twenty-two eyes at 12 months postoperatively were included and analyzed. Despite a general increase in macular thickness measurements overall during the first postoperative weeks, no changes to the integrity of inner segment/outer segment junction, outer nuclear layer, external limiting membrane, or retinal pigment endothelium were detected. The neuroretina returned to baseline by 3 months after surgery and there was no significant difference between preoperative and postoperative measurements after 3-month thickness values.
  
  
  CONCLUSIONS
  Ultraviolet light exposure for light-adjustable IOL adjustments did not influence the incidence of postoperative macular edema and did not induce any changes in the macular layers.
authors.forename: Fritz H
authors.initials: FH
authors.lastname: Hengerer
authors.forename: Michael
authors.initials: M
authors.lastname: Müller
authors.forename: H Burkhard
authors.initials: HB
authors.lastname: Dick
authors.forename: Ina
authors.initials: I
authors.lastname: Conrad-Hengerer
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001813:Blood-Retinal Barrier / Q000502:physiology; D005451:Fluorescein Angiography; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis / Q000503:physiopathology*; D009929:Organ Size; D018918:Phacoemulsification; D011446:Prospective Studies; D011474:Prosthesis Design; D019591:Pseudophakia / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014466:Ultraviolet Rays; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal