title: Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: the way forward.
abstract: Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.
authors.affiliation: Dept of Pediatric Pulmonology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands Dept of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Wieying
authors.initials: W
authors.lastname: Kuo
authors.affiliation: Dept of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Mariette P C
authors.initials: MP
authors.lastname: Kemner-van de Corput
authors.affiliation: Dept of Pediatric Pulmonology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands Biomedical Imaging Group Rotterdam, Depts of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Adria
authors.initials: A
authors.lastname: Perez-Rovira
authors.affiliation: Biomedical Imaging Group Rotterdam, Depts of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands Dept of Computer Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Marleen
authors.initials: M
authors.lastname: de Bruijne
authors.affiliation: Université Sorbonne Paris Cité, Faculté de Médecine Paris Descartes, Paris, France AP-HP, Hôpitaux Universitaires Paris Centre, Hôpital Cochin, Service d'Explorations Fonctionnelles, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fajac
authors.affiliation: Dept of Pediatric Pulmonology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands Dept of Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Harm A W M
authors.initials: HA
authors.lastname: Tiddens
authors.affiliation: Dept of Radiology, Erasmus MC, Rotterdam, The Netherlands marcel.vanstraten@erasmusmc.nl.
authors.forename: Marcel
authors.initials: M
authors.lastname: van Straten
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging* / Q000473:pathology; D018450:Disease Progression; D005060:Europe; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D010363:Pattern Recognition, Automated; D019047:Phantoms, Imaging; D013902:Radiography, Thoracic / Q000592:standards*; D015203:Reproducibility of Results; D012119:Respiration; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed / Q000592:standards*; D016896:Treatment Outcome; D055815:Young Adult