title: MicroRNAs as circulating biomarkers in acute coronary syndromes: A review.
abstract: Coronary artery disease (CAD) and its complications remain the most common cause of death worldwide. Cardiac troponins (cTn) are standard biomarkers used today for diagnosis and risk stratification of myocardial infarction (MI). Increasing efforts are made to develop additional, new biomarkers for more effective and safe rule-in and rule-out of MI patients at the emergency department. During the past decade, microRNAs (miRNAs) have emerged as new, potential diagnostic biomarkers in several diseases, including MI. In this review, we aimed to summarize some of the prominent studies in the field, and discuss the potential value of miRNAs in the diagnosis of MI.
authors.affiliation: 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen hospital, Vienna, Austria; Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Ahlin
authors.affiliation: 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen hospital, Vienna, Austria; Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: John
authors.initials: J
authors.lastname: Arfvidsson
authors.affiliation: 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen hospital, Vienna, Austria.
authors.forename: Kris G
authors.initials: KG
authors.lastname: Vargas
authors.affiliation: Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Stojkovic
authors.affiliation: 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen hospital, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria; Sigmund Freud University, Medical Faculty, Vienna, Austria.
authors.forename: Kurt
authors.initials: K
authors.lastname: Huber
authors.affiliation: Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria; Core Facilities, Medical University of Vienna, Vienna, Austria. Electronic address: johann.wojta@meduniwien.ac.at.
authors.forename: Johann
authors.initials: J
authors.lastname: Wojta
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D023903:Coronary Restenosis / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D005819:Genetic Markers; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D011237:Predictive Value of Tests; D011379:Prognosis; D014336:Troponin / Q000097:blood
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs; D014336:Troponin
keywords: Acute coronary syndrome; Biomarker; MicroRNA; Troponin