title: Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population: The Nagahama Study.
abstract: Chronic obstructive pulmonary disease (COPD) is a possible risk factor for cardiovascular disease. The association of COPD with the pathogenicity of infection with Chlamydia pneumoniae and Mycoplasma pneumoniae is controversial. We conducted a cross-sectional study to clarify the association between atypical pneumoniae seropositivity and COPD in a general population. We also investigated genetic polymorphisms conferring susceptibility to a pneumonia titer. The study included 9040 Japanese subjects (54 ± 13 years). COPD was defined as a ratio of forced expiratory volume in 1 second to forced vital capacity of less than 70%. Serum levels of IgA and IgG antibodies to C pneumoniae were determined using an enzyme-linked immunoassay, and M pneumoniae seropositivity was assessed by a particle agglutination test. Subjects seropositive for C pneumoniae (26.1%) had a higher prevalence of COPD (seropositive, 5.8%; seronegative, 3.1%; P < 0.001) after adjustment for age, sex, height, weight, and smoking status. The association between M pneumoniae seropositivity (20.4%) and COPD was also significant in covariate-adjusted analysis (P < 0.001). A genome-wide association analysis of the C pneumoniae IgA index identified a susceptible genotype (rs17634369) near the IKZF1 gene, and the seropositive rate of C pneumoniae significantly differed among genotypes (AA, 22.5; AG, 25.3; GG, 29.7%, P < 0.001). On multiple regression analysis, seropositivity for both C pneumoniae (odds ratio = 1.41, P = 0.004) and M pneumoniae (odds ratio = 1.60, P = 0.002) was an independent determinant for COPD, while no direct association was found with the rs17634369 genotype. Seropositivity for both C pneumoniae and M pneumoniae is an independent risk factor for COPD in the general population.
authors.affiliation: From the Department of Respiratory Medicine (SM, HM, II, YI, KM, MM); Center for Genomic Medicine, Kyoto University Graduate School of Medicine (YT, KS, TK, MT, CT, RY, FM); Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto (SK); Center for Preventive Medical Science, Chiba University, Chiba (AS); Department of Health Informatics, Kyoto University School of Public Health (TN); and Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (KC).
authors.forename: Shigeo
authors.initials: S
authors.lastname: Muro
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Hisako
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Setoh
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Meiko
authors.initials: M
authors.lastname: Takahashi
authors.forename: Isao
authors.initials: I
authors.lastname: Ito
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Murase
authors.forename: Chikashi
authors.initials: C
authors.lastname: Terao
authors.forename: Shinji
authors.initials: S
authors.lastname: Kosugi
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamada
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sekine
authors.forename: Takeo
authors.initials: T
authors.lastname: Nakayama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Chin
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000235:genetics; D016993:Chlamydophila pneumoniae / Q000276:immunology; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000453:epidemiology* / Q000235:genetics; D009177:Mycoplasma pneumoniae / Q000276:immunology; D016017:Odds Ratio; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D012044:Regression Analysis; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D000888:Antibodies, Anti-Idiotypic; C497239:IKZF1 protein, human; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D051740:Ikaros Transcription Factor