title: The Effects of Bairesi Complex Prescription (a Uyghur Medicine Prescription) and Its Five Crude Herbal Extracts on Melanogenesis in G-361 Cells.
abstract: Vitiligo is considered a preimmune stage of a disease that is not well clarified. This condition is difficult to treat because there is no definite cure. Uyghur medicine is an important part of traditional Chinese medicine. There are many types of prescriptions that are used for the treatment of vitiligo. Bairesi complex prescription is one of the active prescriptions for vitiligo that is used in the clinic. However, the intensities of melanogenesis due to uses of Bairesi complex prescription and its five constituent crude herbs have not been reported yet. In the present study, we found that the hot water extracts of Bairesi complex prescription and the crude herbs were more effective in eliciting melanin production in G-361 cells than the EtOH extracts. Furthermore, the Bairesi complex prescription exhibited less cytotoxicity and was more effective in melanin formation than the five crude herbal extracts. In the present study, we also discuss the mechanisms of melanogenesis due to the use of the Bairesi complex prescription and its single crude herbal extracts.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-0086, Japan.
authors.forename: Xuedan
authors.initials: X
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-0086, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ishikawa
authors.affiliation: Department of Science, Uyghur Medicine Hospital, Urumqi 830049, China.
authors.forename: Arkin
authors.initials: A
authors.lastname: Mansur
authors.affiliation: Department of Science, Uyghur Medicine Hospital, Urumqi 830049, China.
authors.forename: Aynur
authors.initials: A
authors.lastname: Emet
authors.affiliation: Department of Science, Uyghur Medicine Hospital, Urumqi 830049, China.
authors.forename: Ezimet
authors.initials: E
authors.lastname: Nasir
authors.affiliation: Department of Science, Uyghur Medicine Hospital, Urumqi 830049, China.
authors.forename: Repket
authors.initials: R
authors.lastname: Semet
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-0086, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kobayashi