title: [Telomerase reverse transcriptase (TERT) promoter mutations in the tumors of human endocrine organs: Biological and prognostic value].
abstract: The analysis of the data available in the literature has shown that telomerase reverse transcriptase TERT promoter may serve as promising markers of malignancy, aggressive disease course, and poor prognosis for malignant tumors of endocrine organs. Considering the established association of mutations with tumors having a poor prognosis (high-grade and anaplastic carcinoma of the thyroid), it is reasonable to perform prognostic-value investigations in a group of low-grade thyroid carcinomas that may occasionally recur and may be resistant to radioactive iodine therapy, i.e. can demonstrate a poor course and prognosis. TERT promoter mutations may be a specific marker of the clinically aggressive forms of adrenocortical carcinoma, but the determination of its diagnostic value calls for additional investigations that will have the larger number cases and establish the association with clinical features and survival rates.
authors.affiliation: Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: L S
authors.initials: LS
authors.lastname: Selivanova
authors.affiliation: Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Volganova
authors.affiliation: Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Abrosimov
mesh_terms: D018450:Disease Progression; D004701:Endocrine Gland Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D011379:Prognosis; D011401:Promoter Regions, Genetic; D019098:Telomerase / Q000235:genetics*
chemical_list: C509186:TERT protein, human; D019098:Telomerase