title: Functional interplay between PPM1G and the transcription elongation machinery.
abstract: Transcription elongation is a critical regulatory step in the gene expression cycle. One key regulator of the switch between transcription initiation and elongation is the P-TEFb kinase, which phosphorylates RNA polymerase II (Pol II) and several negative elongation factors to relieve the elongation block at paused promoters to facilitate productive elongation. Here, we highlight recent findings signifying the role of the PPM1G/PP2Cγ phosphatase in activating and maintaining the active transcription elongation state by regulating the availability of P-TEFb and blocking its assembly into the catalytic inactive 7SK small nuclear ribonucleoprotein (snRNP) complex.
authors.affiliation: Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
authors.forename: Swapna Aravind
authors.initials: SA
authors.lastname: Gudipaty
authors.affiliation: Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Iván
authors.initials: I
authors.lastname: D'Orso
keywords: 7SK snRNP; DNA damage signaling; NF-κB; P-TEFb; PPM1G/PP2Cγ; RNA polymerase II; phosphatase; transcription elongation