title: Cristobalite and Hematite Particles in Human Brain.
abstract: Foreign substances get into the internal environment of living bodies and accumulate in various organs. Cristobalite and hematite particles in the glial cells of pons cerebri of human brain with diagnosis of Behhet disease with scanning electron microscopy (SEM), energy-dispersive microanalysis (EDX), and transmission electron microscopy (TEM) with diffraction were identified. SEM with EDX revealed the matter of irregular micrometer-sized particles sometimes forming polyhedrons with fibrilar or stratified structure. It was found in some particles Ti, Fe, and Zn. Some particles contained Cu. TEM and electron diffraction showed particles of cristobalite and hematite. The presence of the particles can be a result of environmental effect, disruption of normal metabolism, and transformation of physiologically iron-ferrihydrite into more stable form-hematite. From the size of particles can be drawn the long-term accumulation of elements in glial cells.
authors.affiliation: Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovakia. martin.kopani@fmed.uniba.sk.
authors.forename: Martin
authors.initials: M
authors.lastname: Kopani
authors.affiliation: 2nd Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Kopaniova
authors.affiliation: Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Trnka
authors.affiliation: STU Center for Nanodiagnosis, Slovak University of Technology, Bratislava, Slovakia.|Department of Geology of Mineral Deposits, Faculty of Natural Science, Comenius University, Bratislava, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Caplovicova
authors.affiliation: Cytopathos Ltd, Bratislava, Slovakia.
authors.forename: B
authors.initials: B
authors.lastname: Rychly
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, Bratislava, Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Jakubovsky
mesh_terms: D001528:Behcet Syndrome / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D005290:Ferric Compounds / Q000378:metabolism*; D006801:Humans; D008297:Male; D008670:Metals / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000378:metabolism*
chemical_list: D005290:Ferric Compounds; D008670:Metals; C000499:ferric oxide; D012822:Silicon Dioxide
keywords: Behcet disease; Cristobalite; Diffraction; Hematite; Metals; Particles