title: Analysis of PI3K pathway components in human cancers.
abstract: Recent advances in genomics, proteomics, cell biology and biochemistry of tumors have revealed new pathways that are aberrantly activated in numerous cancer types. However, the enormous amount of data available in this field may mislead scientists in focused research. As cancer cell growth and progression is often dependent upon the phosphoinositide 3-kinase (PI3K)/AKT pathway, there has been extensive research into the proteins implicated in the PI3K pathway. Using data available in the Human Protein Atlas database, the current study investigated the expression of 25 key proteins that are known to be involved with PI3K pathway activation in a distinct group of 20 cancer types. These proteins are AKTIP, ARP1, BAD, GSK3A, GSK3B, MERTK-1, PIK3CA, PRR5, PSTPIP2, PTEN, FOX1, RHEB, RPS6KB1, TSC1, TP53, BCL2, CCND1, WFIKKN2, CREBBP, caspase-9, PTK2, EGFR, FAS, CDKN1A and XIAP. The analysis revealed pronounced expression of specific proteins in distinct cancer tissues, which may have the potential to serve as targets for treatments and provide insights into the molecular basis of cancer.
authors.affiliation: Faculty of Arts and Sciences, The Arab American University - Jenin, Jenin 11184, Palestine.
authors.forename: Jamila
authors.initials: J
authors.lastname: Daragmeh
authors.affiliation: Qasemi Research Center, Al-Qasemi Academic College of Education, Baqa El-Gharbia 30100, Israel.
authors.forename: Waseim
authors.initials: W
authors.lastname: Barriah
authors.affiliation: Faculty of Arts and Sciences, The Arab American University - Jenin, Jenin 11184, Palestine; Qasemi Research Center, Al-Qasemi Academic College of Education, Baqa El-Gharbia 30100, Israel.
authors.forename: Bashar
authors.initials: B
authors.lastname: Saad
authors.affiliation: Faculty of Arts and Sciences, The Arab American University - Jenin, Jenin 11184, Palestine; Qasemi Research Center, Al-Qasemi Academic College of Education, Baqa El-Gharbia 30100, Israel.
authors.forename: Hilal
authors.initials: H
authors.lastname: Zaid
keywords: AKT; EGFR; Human Protein Atlas; PI3K; PTEN; TSC1; cancer; tumorigenesis