title: Pharmacogenomics: Overview of Applications and Relation to Infusion Therapy.
abstract: Pharmacogenomics (PGx) describes the relationship between an individual's genes and his or her response to drug therapy. Data are accumulating that indicate that PGx has application in the clinical setting for drugs across therapeutic categories, including drugs that are administered intravenously and are of greater familiarity to infusion nurses. This article provides an overview of the science and presents common examples of PGx as it relates to drug and/or drug dose selection. Additionally, there are brief summaries of the role infusion nurses can play relative to toxicity monitoring, patient education, and other aspects of PGx.
authors.affiliation: Manchester University College of Pharmacy, Fort Wayne, Indiana (Drs Kisor and Smith); Ferris State University, Big Rapids, Michigan (Dr Bright); and Cedarville University, Cedarville, Ohio (Dr Manion). David F. Kisor, PharmD, BS, is the chair of pharmaceutical sciences at Manchester University College of Pharmacy. His focus is on the fields of pharmacokinetics-related pharmacogenomics. He has more than 40 publications, including a textbook on pharmacogenetics, and he has served as the chair of the pharmacogenomics special interest group of the American Association of Colleges of Pharmacy. David R. Bright, PharmD, BS, is an associate professor of pharmacy practice at Ferris State University. His focus is on community and ambulatory care pharmacy practice. He has emphasized the incorporation of pharmacogenomics into medication therapy management and collaborative drug therapy management, where he works to evaluate implementation models in the community and in transition-of-care settings. Chelsea R. Manion, PharmD, practices in oncology, inpatient, and infusion-center settings, as well as among underserved populations. Her focus in oncology care is on symptom management, patient education, and interdisciplinary health care collaboration. She is an assistant professor of pharmacy practice at Cedarville University in Cedarville, Ohio. Thomas R. Smith, PharmD, is trained in psychiatry and neurology. He currently focuses his efforts in the inpatient psychiatry setting on therapeutics and patient education. He has included pharmacogenomic data in drug therapy management, focusing on clinical applications. Dr. Smith is an assistant professor of pharmacy practice at Manchester University College of Pharmacy, Fort Wayne, Indiana.
authors.forename: David F
authors.initials: DF
authors.lastname: Kisor
authors.forename: David R
authors.initials: DR
authors.lastname: Bright
authors.forename: Chelsea R
authors.initials: CR
authors.lastname: Manion
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Smith
mesh_terms: D054316:Biomarkers, Pharmacological; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods*; D024802:Nurse's Role; D010597:Pharmacogenetics; D057285:Precision Medicine / Q000379:methods*; D014481:United States
chemical_list: D054316:Biomarkers, Pharmacological