title: A Unique Case of Aortic Thrombosis With Elevated Lipoprotein(a).
abstract: Aortic thrombosis is a rare condition that can be caused by atherosclerosis, aneurysms, thrombophilia, vasculitis, trauma, and malignancy. Symptoms vary based on thrombus size and site of embolization. It can lead to devastating complications including acute limb ischemia, myocardial infarction, stroke, and other target organ ischemia. Diagnosis is based on clinical presentation, imaging findings, and relevant laboratory work-up. Although not well defined, management for aortic thrombosis includes surgical intervention, such as thromboembolectomy, and conservative measures, such as anticoagulation. Here, we present a unique case of aortic thrombosis causing acute lower limb ischemia with elevated lipoprotein(a) and other comorbidities. Based on our literature review, our article is the first to establish the connection between elevated lipoprotein(a) and aortic thrombosis in the nonaneurysmal aorta.
authors.affiliation: Minneapolis Heart Institute Research Foundation, Minneapolis, MN nedaa.skeik@allina.com.
authors.forename: Claire A
authors.initials: CA
authors.lastname: Ostertag-Hill
authors.affiliation: Vascular Surgery, Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Titus
authors.affiliation: Vascular Medicine Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN.
authors.forename: Nedaa
authors.initials: N
authors.lastname: Skeik
mesh_terms: D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D001018:Aortic Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D001027:Aortography / Q000379:methods; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D000072226:Computed Tomography Angiography; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D017270:Lipoprotein(a) / Q000097:blood*; D035002:Lower Extremity / Q000098:blood supply*; D008875:Middle Aged; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D017270:Lipoprotein(a)
keywords: aortic thrombosis; limb ischemia; lipoprotein(a)