title: Fatal Septicemia Linked to Transmission of MRSA Clonal Complex 398 in Hospital and Nursing Home, Denmark.
abstract: We describe 2 fatal cases of methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 septicemia in persons who had no contact with livestock. Whole-genome sequencing of the isolated MRSA strains strongly suggest that both were of animal origin and that the patients had been infected through 2 independent person-to-person transmission chains.
authors.forename: Rikke Thoft
authors.initials: RT
authors.lastname: Nielsen
authors.forename: Michael
authors.initials: M
authors.lastname: Kemp
authors.forename: Anette
authors.initials: A
authors.lastname: Holm
authors.forename: Marianne Nielsine
authors.initials: MN
authors.lastname: Skov
authors.forename: Mette
authors.initials: M
authors.lastname: Detlefsen
authors.forename: Henrik
authors.initials: H
authors.lastname: Hasman
authors.forename: Frank Møller
authors.initials: FM
authors.lastname: Aarestrup
authors.forename: Rolf Sommer
authors.initials: RS
authors.lastname: Kaas
authors.forename: Jesper Boye
authors.initials: JB
authors.lastname: Nielsen
authors.forename: Henrik
authors.initials: H
authors.lastname: Westh
authors.forename: Hans Jørn
authors.initials: HJ
authors.lastname: Kolmos
mesh_terms: D000368:Aged; D000818:Animals; D003428:Cross Infection; D003718:Denmark; D000067565:Farmers; D017809:Fatal Outcome; D005260:Female; D016680:Genome, Bacterial; D006761:Hospitals; D006801:Humans; D058751:Livestock; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification* / Q000235:genetics; D008875:Middle Aged; D009735:Nursing Homes; D010802:Phylogeny; D006435:Renal Dialysis / Q000009:adverse effects; D018805:Sepsis; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology* / Q000635:transmission*
keywords: antimicrobial resistance; bacteremia; bacteria; bacterial infections; disease transmission; infectious; livestock; methicillin-resistant Staphylococcus aureus; molecular epidemiology; spa typing; staphylococci