title: Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients.
abstract: OBJECTIVE
  Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients.
  
  
  RESULTS
  In this study CSF IGF-1 and insulin levels of 45 SSPE and 25 age-matched control patients were investigated. CSF IGF-1 levels were significantly higher in SSPE patients at stage 4, compared to other stages (p 0.05). CSF insulin and IGF-1 levels were both positively correlated with serum measles IgG.
  
  
  CONCLUSIONS
  The correlation between CSF insulin and IGF-1 levels and serum measles virus IgG titer may be the result of, insulin activating IGF-1 receptors, and consequently, IGF-1 stimulating, plasma cells and enhancing IgG production. Increased IGF-1 may also, inhibit the phosphorylation of tau. Further studies examining the, correlation between IGF-1, insulin, tau, and PHF-tau levels in the same, patients may clarify any possible pathogenetic relation between these, pathways.
authors.affiliation: Kecioren Education Hospital, Ankara, Turkey. Electronic address: dayilmaz2002@yahoo.com.
authors.forename: Deniz
authors.initials: D
authors.lastname: Yılmaz
authors.affiliation: Dr Sami Ulus Children's Hospital, Ankara, Turkey. Electronic address: drdeniz_yuksel@yahoo.com.tr.
authors.forename: Deniz
authors.initials: D
authors.lastname: Yüksel
authors.affiliation: Polatli State Hospital, Ankara, Turkey. Electronic address: didemakgun@gmail.com.
authors.forename: Didem
authors.initials: D
authors.lastname: Gökkurt
authors.affiliation: Hacettepe University, Faculty of Medicine, Pediatric Endocrinology, Ankara, Turkey. Electronic address: hava.oguz@hacettepe.edu.tr.
authors.forename: Hava
authors.initials: H
authors.lastname: Oguz
authors.affiliation: Hacettepe University, Faculty of Medicine, Pediatric Neurology Department, Ankara, Turkey. Electronic address: banlar@hacettepe.edu.tr.
authors.forename: Banu
authors.initials: B
authors.lastname: Anlar
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007328:Insulin / Q000134:cerebrospinal fluid; D007334:Insulin-Like Growth Factor I / Q000134:cerebrospinal fluid*; D008297:Male; D008457:Measles / Q000276:immunology; D008459:Measles virus / Q000276:immunology; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D010766:Phosphorylation; D012720:Severity of Illness Index; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid* / Q000276:immunology; D016875:tau Proteins / Q000378:metabolism
chemical_list: D007074:Immunoglobulin G; D007328:Insulin; C054369:MAPT protein, human; D016875:tau Proteins; D007334:Insulin-Like Growth Factor I
keywords: Insulin; Insulin-like growth factor-1; Neurofibrillary tangles; Subacute sclerosing panencephalitis