title: Experimental Model of Saccular Abdominal Aortic Aneurysm in Swines with Pericardium Sac.
abstract: OBJECTIVE
  To consider modifications in an experimental model of saccular aortic aneurysm, aiming at better reproducibility, to be used in the development of vascular prostheses.
  
  
  METHODS
  Experimental study in two phases, developed in the Center of Experimental Surgery and Bioterium (CCEB) of the University of Health Sciences of Alagoas (UNCISAL), with 11 hybrid swine, female, mean weight of 20 ± 5 kg, according to modifications in the Perini technique was performed. In the first phase, the aneurysm was confectioned with bovine pericardial patch. In the second phase, fifteen days later, the patency of the aneurysms was confirmed by Doppler ultrasonography. The described variables were aortic and aneurysm sac patency, incidence of rupture, morbidity and mortality. The statistical analysis program used was STATA v.8.
  
  
  RESULTS
  All animals survived to the procedures. Surgical mean time was 73 minutes. Aneurysm rupture, proximal or distal aortic thrombosis, visceral or legs ischemia weren't observed. Parietal thrombus formation was observed in all of the aneurysms, two of which (18%; IC 95% = 3.98 - 48.84) were occluded and nine (82%; IC 95% = 51.15 - 96.01) were patent.
  
  
  CONCLUSIONS
  In this series, the modifications carried out in the technique related to the surgical approach, race, anesthesia, and imaging exams reproduced the experimental model, reducing its costs, without hindering the analysis of the variables. The satisfactory patency ratio allows the method to be used in experimental models for the development of vascular prostheses.
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Maurício de Amorim
authors.initials: Mde A
authors.lastname: Aquino
authors.affiliation: Universidade Estadual de Ciências da Saúde de Alagoas (UNCISAL), Maceió, AL, Brazil.
authors.forename: Svetlana Maria Wanderley de
authors.initials: SM
authors.lastname: Barros
authors.affiliation: Universidade Estadual de Ciências da Saúde de Alagoas (UNCISAL), Maceió, AL, Brazil.
authors.forename: Aldemar Araújo
authors.initials: AA
authors.lastname: Castro
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Guilherme Benjamin Brandão
authors.initials: GB
authors.lastname: Pitta
authors.affiliation: Universidade Federal do Rio Grande do Sul Medical School (FAMED-UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Adamastor Humberto
authors.initials: AH
authors.lastname: Pereira
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D002417:Cattle; D004195:Disease Models, Animal; D005260:Female; D061646:Operative Time; D010496:Pericardium / Q000000981:diagnostic imaging / Q000601:surgery*; D015203:Reproducibility of Results; D013552:Swine; D013997:Time Factors; D018608:Ultrasonography, Doppler; D014654:Vascular Patency