title: Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome.
abstract: OBJECTIVE
  We aimed to evaluate the serum prolidase activity (SPA), malondialdehyde (MDA), and catalase levels in patients with pseudoexfoliation (PEX) syndrome.
  
  
  METHODS
  Thirty-four patients with PEX syndrome and thirty-eight age- and gender-matched healthy subjects were included in this prospective clinical study. Each participant underwent full ophthalmologic examination. The SPA, serum MDA, and catalase levels were measured and compared between the patients with PEX syndrome and healthy subjects.
  
  
  RESULTS
  The SPA was significantly lower in patients with PEX syndrome compared to healthy controls (14.1 ± 7.1 vs. 30.1 ± 4.3 ng/ml; p = 0.001). The mean serum MDA values the of PEX syndrome and control groups were comparable (28.7 ± 5.7 vs. 30.4 ± 5.3 nmol/ml, respectively; p = 0.185). The mean serum catalase level tended to be lower in the PEX group compared to healthy controls (0.12 ± 0.02 vs. 0.21 ± 0.05 k/ml, respectively; p = 0.077).
  
  
  CONCLUSIONS
  Our findings suggest that the SPA was significantly lower in patients with PEX syndrome compared to healthy controls. Thus, prolidase may have a role in the pathogenesis of the PEX syndrome.
authors.affiliation: Department of Ophthalmology, Dumlupinar University School of Medicine, Kutahya, 43270, Turkey. drtetikoglu@yahoo.com.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tetikoğlu
authors.affiliation: Department of Ophthalmology, Dumlupinar University School of Medicine, Kutahya, 43270, Turkey.
authors.forename: Haci Murat
authors.initials: HM
authors.lastname: Sağdik
authors.affiliation: Department of Ophthalmology, Dumlupinar University School of Medicine, Kutahya, 43270, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Aktas
authors.affiliation: Department of Biochemistry, Dışkapı Yıldırım Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Uçar
authors.affiliation: Department of Ophthalmology, Dumlupinar University School of Medicine, Kutahya, 43270, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Özcura
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D004150:Dipeptidases / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay; D017889:Exfoliation Syndrome / Q000201:enzymology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: Catalase; Malondialdehyde; Pseudoexfoliation; Serum prolidase activity