title: Ropinirole-dextran sulfate nanoplex for nasal administration against Parkinson's disease: in silico molecular modeling and in vitro-ex vivo evaluation.
abstract: Dextran sulfate sodium (DS) was allowed to interact ionically with ropinirole hydrochloride (ROPI HCl, an anti-Parkinsonian agent) to synthesize self-assembled ROPI-DS nanoplex. The preliminary objective behind ROPI-DS complexation was to enhance the partitioning of ROPI HCl and thereby its encapsulation into nanocarriers and to improve the nasal membrane permeability. Molecular interactions were computed using in silico molecular modeling. Nanoplex were characterized for physicochemical and partitioning behavior. Optimized ROPI-DS nanoplex was further characterized by spectroscopic and thermal analysis, diffraction studies, morphological and histopathological analysis. In summary, ROPI-DS nanoplex represents a promising nanocarrier material for intranasal administration.
authors.affiliation: a Industrial Pharmacy Laboratory, Department of Pharmaceutics , R. C. Patel Institute of Pharmaceutical Education and Research , Shirpur , Maharashtra , India.
authors.forename: Chandrakantsing Vijaysing
authors.initials: CV
authors.lastname: Pardeshi
authors.affiliation: b Department of Pharmaceutical Sciences , RTM Nagpur University , Nagpur , Maharashtra , India.
authors.forename: Veena Shailendra
authors.initials: VS
authors.lastname: Belgamwar
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000978:Antiparkinson Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D003198:Computer Simulation; D016264:Dextran Sulfate / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers; D004339:Drug Compounding; D007211:Indoles / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism*; D010539:Permeability; D034561:Sheep, Domestic; D046509:Tissue Culture Techniques
chemical_list: D000978:Antiparkinson Agents; D004337:Drug Carriers; D007211:Indoles; C046649:ropinirole; D016264:Dextran Sulfate
keywords: Dextran sulfate sodium; Parkinson’s disease; electrostatic complexation; nanoplex; nasal delivery; ropinirole hydrochloride