title: Effects of N-acetylcysteine and ethyl pyruvate on ischemia-reperfusion injury in experimental electrical burn model.
abstract: OBJECTIVE
  This study was planned as a histopathologic evaluation of the effectiveness of ethyl pyruvate (EP) and N-acetylcysteine (NAC) in reducing electric burn-related organ damage in an experimental model.
  
  
  METHODS
  Four groups of 7 female Wister rats were established. The first was a sham group, the second an electrical burn control group receiving 600 V, the third group received NAC therapy of 20 mg/kg 1 hour after 600 V electrical burn, and the fourth group received 50 mg/kg EP 1 hour after 600 V electrical burn. Heart, kidney, striated muscle, brain, and lung tissues obtained 24 hours postprocedurally were subjected to histopathologic examination, and injury scores were determined. The values determined were then subjected to statistical analysis.
  
  
  RESULTS
  Electrical fire caused significant damage in heart, striated muscle, kidney, and brain tissues. A statistically significant decrease in injury scores in total striated muscle and heart tissue was observed in the 2 treatment groups administered NAC or EP compared to the control group (P= .001). Total kidney injury scores among the groups were significantly lower in the NAC and EP groups compared to the control group (P= .002 and P= .001, respectively). Brain injury examination revealed a significant decrease in injury scores with NAC and EP therapy, both antioxidant agents, in terms of neuron degeneration (P= .004 and P= .001, respectively).
  
  
  CONCLUSIONS
  Electrical burn was observed to cause injury in heart, striated muscle, kidney, and brain tissue. This injury was reduced by the administration of NAC and EP.
authors.affiliation: Faculty of Medicine, Department of Emergency Medicine, Karadeniz Technical University, Trabzon, Turkey. Electronic address: drsuhaturkmen@hotmail.com.
authors.forename: Turkmen
authors.initials: T
authors.lastname: Suha
authors.affiliation: Faculty of Medicine, Department of Emergency Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Asli
authors.affiliation: Faculty of Medicine, Department of Emergency Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Sahin
authors.initials: S
authors.lastname: Aynur
authors.affiliation: Faculty of Medicine, Department of Emergency Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Karaca
authors.initials: K
authors.lastname: Yunus
authors.affiliation: Faculty of Medicine, Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Mentese
authors.initials: M
authors.lastname: Ahmet
authors.affiliation: Faculty of Medicine, Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Demir
authors.initials: D
authors.lastname: Selim
authors.affiliation: Faculty of Medicine, Department of Histology, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Yulug
authors.initials: Y
authors.lastname: Esin
authors.affiliation: Faculty of Medicine, Department of Emergency Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Tatli
authors.initials: T
authors.lastname: Ozgur
authors.affiliation: Faculty of Medicine, Department of Histology, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Neziha Senem
authors.initials: NS
authors.lastname: Ari
authors.affiliation: Faculty of Medicine, Department of Emergency Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Turedi
authors.initials: T
authors.lastname: Süleyman
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D002058:Burns, Electric / Q000150:complications* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D008297:Male; D011773:Pyruvates / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*
chemical_list: D016166:Free Radical Scavengers; D011773:Pyruvates; C046522:ethyl pyruvate; D000111:Acetylcysteine