title: Diabetes mellitus Type II and cognitive capacity in healthy aging, mild cognitive impairment and Alzheimer's disease.
abstract: While diabetes mellitus (DM) Type II has repeatedly been linked to Alzheimer´s disease (AD) and mild cognitive impairment (MCI), longitudinal research is scarce and disease duration has not always been taken into account. In a birth cohort born between 1930 and 1932 we investigated the influence of DM Type II and disease duration on neuropsychological functioning (memory/learning, attention, verbal fluency, visuospatial thinking and abstract thinking) across 14 years. Subjects who developed MCI or AD performed significantly poorer on all neuropsychological tests applied. While significant main effects DM Type II did not arise, its presence led to a significant deterioration of performance in the digit symbol test and visuospatial thinking over time. Additionally, in visuospatial thinking this change was more pronounced for individuals suffering from MCI/AD. We found that, as a concomitant disease DM Type II does not affect memory functioning, which is typically compromised in MCI and early AD. Rather, it may lead to deficits in cognitive flexibility and visuospatial thinking. DM Type II can be considered a frequent comorbid condition which can aggravate the course of MCI and AD. In this respect it may serve as a model for other comorbid conditions in AD.
authors.affiliation: University Hospital Heidelberg, Section of Geriatric Psychiatry, Heidelberg, Germany. Electronic address: Christina.degen@med.uni-heidelberg.de.
authors.forename: Christina
authors.initials: C
authors.lastname: Degen
authors.affiliation: Pontificia Universidad Catolica de Chile, Medicine School, Department of Psychiatry, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Toro
authors.affiliation: Department of Psychiatry, University of Leipzig, Leipzig, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Schönknecht
authors.affiliation: Institute of Psychology, Heidelberg University, Heidelberg, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Sattler
authors.affiliation: University Hospital Heidelberg, Section of Geriatric Psychiatry, Heidelberg, Germany; Institute of Gerontology, Heidelberg University, Heidelberg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schröder
mesh_terms: D000368:Aged; D000375:Aging / Q000523:psychology*; D000544:Alzheimer Disease / Q000150:complications* / Q000523:psychology; D001288:Attention; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D013850:Thinking
keywords: Age; Cognitive decline; Dementia; Neuropsychology