title: Hyponatremia Associated with Hepatocellular Carcinoma.
abstract: Hyponatremia is the most common electrolyte abnormality in clinical practice, and a differential diagnosis of the etiologic disorders is crucial because hyponatremia is associated with many different disease states including malignancies. Although only a few cases of hyponatremia with hepatocellular carcinoma (HCC) have been previously reported, the abnormal expression of arginine vasopressin (AVP) in tumor cells has not been demonstrated. We herein present a rare case of hyponatremia associated with the aberrant expression of AVP in tumor cells of HCC. This case suggests that an extensive diagnostic work-up is needed in patients with hyponatremia because hyponatremia may provide diagnostic clues for the presence of other underlying disorders.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Korea.
authors.forename: Seong
authors.initials: S
authors.lastname: Kwon Ma
authors.forename: Sung
authors.initials: S
authors.lastname: Sun Kim
authors.forename: Eun
authors.initials: E
authors.lastname: Hui Bae
authors.forename: Soo
authors.initials: S
authors.lastname: Wan Kim
mesh_terms: D000368:Aged; D001127:Arginine Vasopressin / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis*; D008297:Male
chemical_list: D001127:Arginine Vasopressin