title: Extracorporeal Respiratory Support With a Miniature Integrated Pediatric Pump-Lung Device in an Acute Ovine Respiratory Failure Model.
abstract: Respiratory failure is one of the major causes of mortality and morbidity all over the world. Therapeutic options to treat respiratory failure remain limited. The objective of this study was to evaluate the gas transfer performance of a newly developed miniature portable integrated pediatric pump-lung device (PediPL) with small membrane surface for respiratory support in an acute ovine respiratory failure model. The respiratory failure was created in six adult sheep using intravenous anesthesia and reduced mechanical ventilation at 2 breaths/min. The PediPL device was surgically implanted and evaluated for respiratory support in a venovenous configuration between the right atrium and pulmonary artery. The hemodynamics and respiratory status of the animals during support with the device gas transfer performance of the PediPL were studied for 4 h. The animals exhibited respiratory failure 30 min after mechanical ventilation was reduced to 2 breaths/min, indicated by low oxygen partial pressure, low oxygen saturation, and elevated carbon dioxide in arterial blood. The failure was reversed by establishing respiratory support with the PediPL after 30 min. The rates of O2transfer and CO2removal of the PediPL were 86.8 and 139.1 mL/min, respectively. The results demonstrated that the PediPL (miniature integrated pump-oxygenator) has the potential to provide respiratory support as a novel treatment for both hypoxia and hypercarbia. The compact size of the PediPL could allow portability and potentially be used in many emergency settings to rescue patients suffering acute lung injury.
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.|Department of Cardiac Surgery, Xijing Hospital, Xi'an, People's Republic of China.
authors.forename: Xufeng
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Pablo G
authors.initials: PG
authors.lastname: Sanchez
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.|Department of Cardiac Surgery, Xijing Hospital, Xi'an, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: A
authors.initials: A
authors.lastname: Claire Watkins
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Tieluo
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Bartley P
authors.initials: BP
authors.lastname: Griffith
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.|Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Zhongjun J
authors.initials: ZJ
authors.lastname: Wu
mesh_terms: D055371:Acute Lung Injury / Q000601:surgery*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D004195:Disease Models, Animal; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006325:Heart Atria / Q000601:surgery; D006355:Heart-Lung Machine; D006439:Hemodynamics; D006801:Humans; D006935:Hypercapnia / Q000628:therapy; D010100:Oxygen / Q000097:blood; D011651:Pulmonary Artery / Q000601:surgery; D012121:Respiration, Artificial / Q000379:methods; D012131:Respiratory Insufficiency / Q000601:surgery*; D012756:Sheep
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
keywords: Animal model; Artificial lung; Gas exchange; Integrated pump-oxygenator; Respiratory failure