title: Secondary acute myeloid leukemia in survivors of Hodgkin lymphoma.
abstract: BACKGROUND
  This large population-based study determined the epidemiology and outcomes of secondary acute myeloid leukemia (sAML) developing in Hodgkin lymphoma survivors.
  
  
  METHODS
  We utilized the Surveillance Epidemiology and End Results (SEER) 9 database to identify 104 cases of sAML.
  
  
  RESULTS
  Patients with sAML (median age: 47 years; 82% <60 years) were significantly younger than de novo AML cases (66 years; p < 0.01). sAML had worse overall survival (OS) than de novo AML (p < 0.01). OS was better in younger patients and in more recent years.
  
  
  CONCLUSIONS
  Older patients with sAML have a dismal OS and should be enrolled in trials of novel therapies. Younger patients have improved OS and hence may benefit from curative intent intensive therapy and allogeneic transplant.
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Vijaya R
authors.initials: VR
authors.lastname: Bhatt
authors.affiliation: Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Smith
authors.initials: S
authors.lastname: Giri
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Verma
authors.affiliation: Department of Internal Medicine, Interfaith Hospital, 1545 Atlantic Avenue, Brooklyn, NY 11213, USA.
authors.forename: Sumit
authors.initials: S
authors.lastname: Dahal
authors.affiliation: Divison of Hematology & Oncology, St Joseph Regional Medical Center, 415 Sixth St., Lewiston, ID 83501, USA.
authors.forename: Binay K
authors.initials: BK
authors.lastname: Shah
authors.affiliation: Department of Medicine, Reading Health System, Sixth Avenue and Spruce Street, Reading, PA 19612, USA.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Pathak
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: R Gregory
authors.initials: RG
authors.lastname: Bociek
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Vose
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: James O
authors.initials: JO
authors.lastname: Armitage
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D018426:SEER Program; D017741:Survivors / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Hodgkin lymphoma; acute myeloid leukemia; survival