title: The relationship between serum lectin-like oxidized LDL receptor-1 levels and systolic heart failure.
abstract: OBJECTIVE
  Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1’s relationship with serum pro-brain natriuretic peptide (NT-proBNP).
  
  
  METHODS
  This was a cross-sectional study of all eligible patients admitted to the department of cardiology of the University Hospital between July 2011 and April 2012.
  
  
  METHODS
  Fifty-five patients with a diagnosis of systolic heart failure and 25 patients without systolic HF were enrolled in this study. Serum C-reactive protein, NT-proBNP, and LOX-1 were studied.
  
  
  RESULTS
  Serum LOX-1 and NT-proBNP levels were significantly higher in the heart failure group and showed a positive correlation with NT-proBNP and negative correlations with left ventricular ejection fraction (EF). In addition, LOX-1 levels in patients with ischaemic cardiomyopathy were significantly higher, while they were similar in patients with dilated cardiomyopathy compared to control subjects.
  
  
  CONCLUSIONS
  Our study demonstrates the utility of the serum LOX-1 levels in the diagnosis of left ventricular systolic heart failure. LOX-1 may have a place in the diagnosis of heart failure, in particular in patients with ischaemic cardiomyopathy.
authors.forename: Feyzullah
authors.initials: F
authors.lastname: Besli
authors.forename: Sumeyye
authors.initials: S
authors.lastname: Gullulu
authors.forename: Saim
authors.initials: S
authors.lastname: Sag
authors.forename: Mesut
authors.initials: M
authors.lastname: Kecebas
authors.forename: Ebru
authors.initials: E
authors.lastname: Acikgoz
authors.forename: Emre
authors.initials: E
authors.lastname: Sarandol
authors.forename: Ali
authors.initials: A
authors.lastname: Aydinlar
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D054143:Heart Failure, Systolic / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D015203:Reproducibility of Results; D051127:Scavenger Receptors, Class E / Q000097:blood*; D013223:Statistics as Topic; D013318:Stroke Volume; D014421:Turkey; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*
chemical_list: D010446:Peptide Fragments; D051127:Scavenger Receptors, Class E; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Left ventricular systolic heart failure; NT pro-brain natriuretic peptide; ejection fraction; lectin-like oxidized LDL receptor-1