title: Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non-human papillomavirus16 viral subtypes.
abstract: The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes.
  
  
  
  This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high-risk non-HPV16 groups.
  
  
  
  High-risk non-HPV16 genotypes accounted for 9% of HPV-related OPC. Of the 27 total high-risk non-HPV16 OPCs, HPV35 was most prevalent (48%). High-risk non-HPV16 OPC presented at a slightly higher age (p = .021) and higher clinical T classification (p = .008) compared to HPV16 OPC, but there was no significant survival difference.
  
  
  
  Clinical characteristics of high-risk non-HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi-institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high-risk HPV types. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1330-1337, 2016.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Indu
authors.initials: I
authors.lastname: Varier
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.
authors.forename: Brieze R
authors.initials: BR
authors.lastname: Keeley
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Rosemarie
authors.initials: R
authors.lastname: Krupar
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.|Department of Otolaryngology - Head and Neck Surgery, University Oklahoma Health Sciences Center, OK, USA.
authors.forename: Alexis
authors.initials: A
authors.lastname: Patsias
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.
authors.forename: Nikita
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.
authors.forename: Arjun K
authors.initials: AK
authors.lastname: Parasher
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Genden
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.
authors.forename: Brett A
authors.initials: BA
authors.lastname: Miles
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA.
authors.forename: Marita
authors.initials: M
authors.lastname: Teng
authors.affiliation: Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, NY, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Bakst
authors.affiliation: Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, NY, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Gupta
authors.affiliation: Department of Medical Oncology, Icahn School of Medicine at Mount Sinai, NY, USA.
authors.forename: Krzysztof J
authors.initials: KJ
authors.lastname: Misiukiewicz
authors.affiliation: Department of Internal Medicine and Health Services Research, Baylor College of Medicine, Houston, TX, USA.|Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center, Houston, TX, USA.
authors.forename: Elizabeth Y
authors.initials: EY
authors.lastname: Chiao
authors.affiliation: Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
authors.affiliation: Head and Neck Cancer Center Ulm, Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Baden-Württemberg, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Laban
authors.affiliation: Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA.
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Demicco
authors.affiliation: Department of Medical Oncology, Icahn School of Medicine at Mount Sinai, NY, USA.
authors.forename: Marshall R
authors.initials: MR
authors.lastname: Posner
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Sikora
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000821:virology*; D016009:Chi-Square Distribution; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000821:virology*; D061809:Human Papillomavirus DNA Tests / Q000379:methods; D052162:Human papillomavirus 16 / Q000145:classification* / Q000235:genetics; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery / Q000821:virology*; D009960:Oropharynx / Q000473:pathology / Q000601:surgery*; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D004279:DNA, Viral
keywords: genotypes; head and neck squamous cell carcinoma; human papillomavirus (HPV); oropharyngeal cancer