title: [Neurotrophic peptides of сerebrolysin as a basis for anticonvulsant effect of the drug].
abstract: OBJECTIVE
  To study an effect of cerebrolysin on the expression and severity of primary-generalized seizures caused by thiosemicarbazide and to analyze the corresponding molecular mechanisms.
  
  
  METHODS
  The effects of cerebrolysin were studied on the thiosemicarbazide model of convulsions in 144 male rats. Cerebrolysin was introduced intraperitoneally in the dose of 2.5 ml/kg of body mass 5 days a week during 18 days.
  
  
  CONCLUSIONS
  Cerebrolysin reduces the severity and duration of seizures caused by thiosemicarbazide and increases the survival rate of animals. Cerebrolysin potentiates the anticonvulsant action of gabapentin and sodium valproate. Neurohistological analysis has shown that the thiosemicarbazide model results in the ischemic brain damage. Cerebrolysin substantially minimizes the ischemic injury of neurocytes induced by thiosemicarbazide and contributes to the restoration of brain tissue morphology.
authors.affiliation: Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Gromova
authors.affiliation: Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kalacheva
authors.affiliation: Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia.
authors.forename: T R
authors.initials: TR
authors.lastname: Grishina
authors.affiliation: Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia.
authors.forename: T E
authors.initials: TE
authors.lastname: Bogacheva
authors.affiliation: Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Demidov
authors.affiliation: Moscow Institute of Physics and Technology, Dolgoprudny.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Torshin
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D008297:Male; D009474:Neurons; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010455:Peptides; D051381:Rats; D012640:Seizures / Q000188:drug therapy*; D012663:Semicarbazides; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000927:Anticonvulsants; D018696:Neuroprotective Agents; D010455:Peptides; D012663:Semicarbazides; C006952:cerebrolysin; C005151:thiosemicarbazide; D014635:Valproic Acid