title: Oxidative Stress: A Promising Target for Chemoprevention.
abstract: Cancer is a leading cause of death worldwide, and treating advanced stages of cancer remains clinically challenging. Epidemiological studies have shown that oxidants and free radicals induced DNA damage is one of the predominant causative factors for cancer pathogenesis. Hence, oxidants are attractive targets for chemoprevention as well as therapy. Dietary agents are known to exert an anti-oxidant property which is one of the most efficient preventive strategy in cancer progression. In this article, we highlight dietary agents can potentially target oxidative stress, in turn delaying, preventing, or treating cancer development. Some of these agents are currently in use in basic research, while some have been launched successfully into clinical trials.
authors.affiliation: Department of Urology, University of Louisville, KY 40202.
authors.forename: Am Sashi Papu
authors.initials: AS
authors.lastname: John
authors.affiliation: Department of Urology, University of Louisville, KY 40202.
authors.forename: Murali K
authors.initials: MK
authors.lastname: Ankem
authors.affiliation: Department of Urology, University of Louisville, KY 40202.
authors.forename: Chendil
authors.initials: C
authors.lastname: Damodaran