title: Common variants in SIRT1 and human longevity in a Chinese population.
abstract: BACKGROUND
  The silent information regulator SIR2/SIRT1gene has been demonstrated as regulating lifespan in many model organisms, including yeast, worms, fruit flies and rodents. SIRT1, the human homolog of SIR2, is considered a candidate gene as a modifier of human life expectancy.
  
  
  METHODS
  In the current study we included 616 long-lived individuals and 846 matched younger controls to investigate associations between 8 common single nucleotide polymorphisms (SNPs) (i.e., rs12778366, rs3758391, rs3740051, rs33957861, rs7896005, rs12413112, rs11599176 and rs4746720) in the SIRT1 gene and human longevity.
  
  
  RESULTS
  The 8 SNPs had strong linkage disequilibrium (LD) and were in an LD block, which was characterized by 4 common haplotypes that capture 99.3% of the genetic variation present within it. We found no evidence for statistically significant associations between the tested SIRT1 SNPs and longevity at the allele, genotype or haplotype levels.
  
  
  CONCLUSIONS
  Current findings show that several common variants in SIRT1 are not associated with human longevity.
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, 571199, Hainan, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lin
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, 571199, Hainan, China.
authors.forename: Dongjing
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, 571199, Hainan, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, the Affiliated Hospital of Hainan Medical College, Haikou, 571199, Hainan, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, 571199, Hainan, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, 571199, Hainan, China.|College of Agriculture, Hainan University, Haikou, 570228, Hainan, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Division of Biostatistics and Human Genetics Center, The University of Texas Health Science Center at Houston, 1200 Herman Pressler, Houston, TX, 77025, USA. yunxin.fu@uth.tmc.edu.|Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, 650091, Yunnan, China. yunxin.fu@uth.tmc.edu.
authors.forename: Yunxin
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, 571199, Hainan, China. caiww591020@163.com.
authors.forename: Wangwei
authors.initials: W
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D060005:Genotyping Techniques; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056564:Sirtuin 1 / Q000235:genetics*
chemical_list: C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Case–control association design; Human longevity; SIRT1; Single nucleotide polymorphism