title: Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13.
abstract: Focal epithelial hyperplasia (FEH), or Heck's disease, is an uncommon benign proliferation of oral mucosa caused by the human papillomavirus (HPV), particularly subtypes 13 and 32. The disease typically presents in young Native American patients and is characterized by multiple asymptomatic papules and nodules on the oral mucosa, lips, tongue, and gingiva. The factors that determine susceptibility to FEH are unknown, but the ethnic and geographic distribution of FEH suggests that genetic predisposition, particularly having the human lymphocytic antigen DR4 type, may be involved in pathogenesis. We report a case of FEH with polymerase chain reaction detection of HPV13 in a healthy 11-year-old Hispanic girl and discuss the current understanding of disease pathogenesis, susceptibility, and treatment.
authors.affiliation: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Brehm
authors.affiliation: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Katie
authors.initials: K
authors.lastname: Gordon
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.|Department of Pathology, Children's Medical Center, Dallas, Texas.
authors.forename: Miahil
authors.initials: M
authors.lastname: Firan
authors.affiliation: Laboratory for Molecular Studies in Mucocutaneous Diseases, Department of Dermatology, Medical School, University of Texas at Houston, Houston, Texas.
authors.forename: Peter
authors.initials: P
authors.lastname: Rady
authors.affiliation: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Nnenna
authors.initials: N
authors.lastname: Agim
mesh_terms: D001707:Biopsy, Needle; D002648:Child; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D053685:Laser Therapy / Q000379:methods; D009061:Mouth Mucosa / Q000473:pathology*; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D012075:Remission, Spontaneous; D012720:Severity of Illness Index