title: Protective Effects of Quetiapine on Metabolic and Inflammatory Abnormalities in Schizophrenic Patients during Exacerbated Stage.
abstract: Inflammation has been considered important in the pathogenesis of schizophrenia. Increasing evidence reveals that patients with schizophrenia have abnormal expression of cytokines, which are related to development of metabolic abnormalities. Metabolic abnormality has become a critical issue, though its longitudinal relationship with the disorder, such as the antipsychotics influence, is unclear. We aimed to investigate whether abnormalities of metabolic parameters and cytokine levels in acute exacerbated schizophrenic patients existed, and whether intervention of antipsychotic could help. The present study analyzed peripheral cytokines and metabolic/hemodynamic parameters in healthy controls and acute exacerbated schizophrenic patients hospitalized for three weeks under the unique treatment of quetiapine, a well-known second-generation antipsychotic. Our results showed that patients with schizophrenia were predisposed to metabolic abnormalities in acute exacerbation, including body mass index (BMI) and waist circumference (WC). The patients were also prone to dysglycemia, lower high-density lipoprotein cholesterol (HDL-c) levels, and higher blood pressure with concomitant of elevation of interleukin (IL)-2, IL-6 and IL-10 in which IL-6 was associated with BMI. After quetiapine treatment, IL-2, IL-6 and IL-10 remained higher than the controls, but IL-10 was significantly decreased in follow-up comparison. Glycemic-related indexes, HDL-c and IL-10 levels were significantly changed by variance analysis. Results of the present study imply that acute exacerbated schizophrenic patients with metabolism abnormalities may involve disruption of expression of cytokines, and that quetiapine may have therapeutic effects. Nonetheless, metabolism parameters of patients undergoing treatment with quetiapine should be closely monitored.
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital Songshan Branch, Taipei 10581, Taiwan, Republic of China.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Kao
authors.affiliation: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan, Republic of China.
authors.forename: Chih-Yuan
authors.initials: CY
authors.lastname: Ko
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital Songshan Branch, Taipei 10581, Taiwan, Republic of China.
authors.forename: Sheng-Chiang
authors.initials: SC
authors.lastname: Wang
authors.affiliation: Department of Physiology and Biophysics, National Defense Medical Center, Taipei 11490.|Department of Psychiatry, Tri-Service General Hospital, Taipei 11490, Taiwan, Republic of China.
authors.forename: Yia-Ping
authors.initials: YP
authors.lastname: Liu
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control*; D016753:Interleukin-10 / Q000097:blood; D008297:Male; D008875:Middle Aged; D000069348:Quetiapine Fumarate / Q000627:therapeutic use*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism*; D055105:Waist Circumference
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D008076:Cholesterol, HDL; D016207:Cytokines; C508609:IL10 protein, human; D016753:Interleukin-10; D000069348:Quetiapine Fumarate