title: Prognostic value of plasma biomarkers in patients with acute coronary syndrome: a review of advances in the past decade.
abstract: Acute coronary syndrome (ACS), especially myocardial infarction, commonly known as a heart attack, is a serious life-threatening cardiovascular disease. Despite dramatic therapeutic advances, there have still been more than 20% patients with ACS suffering recurrent adverse cardiovascular events 3 years after disease onset. Therefore, the aim to prevent cardiac death caused by the heart attack remains challenging. Plasma biomarkers, originally developed to complement clinical assessment and electrocardiographic examination for the diagnosis of ACS, have been reported to play important prognostic roles in predicting adverse outcomes. These biomarkers mirror different pathophysiological mechanisms in association with ACS. In this review, we focus on advances of prognostic biomarkers in the past decade for short- and long-term risk assessment and management of patients with ACS.
authors.affiliation: Department of Cardiology, Shanghai Xuhui Central Hospital/Shanghai Clinical Research Center, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Richard Y
authors.initials: RY
authors.lastname: Cao
authors.affiliation: Department of Cardiology, Shanghai Xuhui Central Hospital/Shanghai Clinical Research Center, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Hongchao
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Shanghai Xuhui Central Hospital/Shanghai Clinical Research Center, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Junjun
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario, Canada.|Department of Medicine, Kingston General Hospital, Kingston, Ontario, Canada.
authors.forename: Damian P
authors.initials: DP
authors.lastname: Redfearn
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D053607:Adrenomedullin / Q000032:analysis; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000032:analysis; D006020:Glycopeptides / Q000032:analysis; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000032:analysis; D011379:Prognosis; D014336:Troponin / Q000097:blood; D042561:Vascular Endothelial Growth Factor B / Q000032:analysis
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D050556:Fatty Acid-Binding Proteins; D006020:Glycopeptides; D035683:MicroRNAs; D014336:Troponin; D042561:Vascular Endothelial Growth Factor B; C048197:copeptins; D020097:Natriuretic Peptide, Brain; D053607:Adrenomedullin
keywords: acute coronary syndrome; biomarker; myocardial infarction; prognosis