title: Antigen-specificity using chimeric antigen receptors: the future of regulatory T-cell therapy?
abstract: Adoptive regulatory T-cell (Treg) therapy using autologous Tregs expandedex vivois a promising therapeutic approach which is currently being investigated clinically as a means of treating various autoimmune diseases and transplant rejection. Despite this, early results have highlighted the need for potent Tregs to yield a substantial clinical advantage. One way to achieve this is to create antigen-specific Tregs which have been shown in pre-clinical animal models to have an increased potency at suppressing undesired immune responses, compared to polyclonal Tregs. This mini review outlines where Treg therapy currently stands and discusses the approaches which may be taken to generate antigen-specific Tregs, including the potential use of chimeric antigen receptors (CARs), for future clinical trials.
authors.affiliation: Immunoregulation Laboratory, MRC Centre for Transplantation, Guy's Hospital, King's College London, London SE1 9RT, U.K. NIHR Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust & King's College London, London SE1 9RT, U.K.
authors.forename: Dominic
authors.initials: D
authors.lastname: Boardman
authors.affiliation: CAR Mechanics Group, Department of Research Oncology, Guy's Hospital, King's College London, London SE1 9RT, U.K.
authors.forename: John
authors.initials: J
authors.lastname: Maher
authors.affiliation: Immunoregulation Laboratory, MRC Centre for Transplantation, Guy's Hospital, King's College London, London SE1 9RT, U.K. NIHR Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust & King's College London, London SE1 9RT, U.K.
authors.forename: Robert
authors.initials: R
authors.lastname: Lechler
authors.affiliation: Immunoregulation Laboratory, MRC Centre for Transplantation, Guy's Hospital, King's College London, London SE1 9RT, U.K. School of Health, Sport and Bioscience, University of East London, Stratford Campus, Water Lane, London E15 4LZ, U.K. giovanna.lombardi@kcl.ac.uk lesley.smyth@kcl.ac.uk.
authors.forename: Lesley
authors.initials: L
authors.lastname: Smyth
authors.affiliation: Immunoregulation Laboratory, MRC Centre for Transplantation, Guy's Hospital, King's College London, London SE1 9RT, U.K. NIHR Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust & King's College London, London SE1 9RT, U.K. giovanna.lombardi@kcl.ac.uk lesley.smyth@kcl.ac.uk.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000941:Antigens; D011948:Receptors, Antigen, T-Cell
keywords: adoptive cell therapy; antigen-specific; autoimmune disease; chimeric antigen receptor; regulatory T-cell; transplantation