title: Predictors of cure in rifampicin-resistant tuberculosis in prison settings with low loss to follow-up.
abstract: OBJECTIVE
  To determine the factors predictive of cure among inmates with pulmonary rifampicin-resistant tuberculosis (R(R)-TB).
  
  
  METHODS
  A total of 444 new and previously treated patients with pulmonary R(R)-TB who started treatment with second-line anti-tuberculosis drugs in the penitentiary system of Azerbaijan during the period 1 April 2007-28 February 2013 were retrospectively subjected to multivariate logistic regression analysis.
  
  
  RESULTS
  Of the 444 patients, 78.4% were cured. A higher number of effective bactericidal drugs in the regimen at months 7-12 and 13-18, normal chest X-ray and body mass index ⩾18.5 kg/m(2) at the treatment start significantly increased the chances of cure both in all cases (aOR 2.29, aOR 4.39, aOR 1.18, aOR 1.98 and aOR 1.97, respectively) and in retreatment cases (aOR 3.88, aOR 5.02, aOR 1.17, aOR 2.26 and aOR 1.90, respectively). There was no added benefit of using moxifloxacin (MFX) as compared to levofloxacin (LVX) in case of resistance to ofloxacin.
  
  
  CONCLUSIONS
  The use of a higher number of effective bactericidal drugs after month 6 of treatment for R(R)-TB was found to be the main factor associated with cure. No added benefit of using MFX instead of LVX was found. High cure rates can be achieved among vulnerable population groups such as prisoners if comprehensive TB control measures are in place to ensure low loss to follow-up.
authors.affiliation: Main Medical Department, Ministry of Justice, Baku, Azerbaijan; Department of Pulmonary Medicine, University of Tartu, Tartu, Estonia.
authors.forename: E
authors.initials: E
authors.lastname: Gurbanova
authors.affiliation: Main Medical Department, Ministry of Justice, Baku, Azerbaijan.
authors.forename: R
authors.initials: R
authors.lastname: Mehdiyev
authors.affiliation: Department of Communicable Disease Prevention and Control, Reykjavik Health Care Services, Reykjavik, Iceland.
authors.forename: K
authors.initials: K
authors.lastname: Blondal
authors.affiliation: Department of Pulmonary Medicine, University of Tartu, Tartu, Estonia, Lung Clinic, Tartu University Hospital, Tartu, Estonia.
authors.forename: A
authors.initials: A
authors.lastname: Altraja
mesh_terms: D000293:Adolescent; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D001382:Azerbaijan; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000187:drug effects* / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015999:Multivariate Analysis; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011329:Prisoners; D011330:Prisons; D012074:Remission Induction; D012189:Retrospective Studies; D012293:Rifampin / Q000627:therapeutic use*; D013183:Sputum / Q000382:microbiology; D013997:Time Factors; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin