title: A Systemic Capillary Leak Syndrome (Clarkson Syndrome) in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting.
abstract: Systemic Capillary Leak Syndrome (SCLS) is a rare disease with poor prognosis, characterized by the occurrence of mucocutaneous and visceral edema with hypotension, hemoconcentration, and unexpected hypoalbuminemia. The disease can be idiopathic (Clarkson syndrome) or secondary to other diseases and treatments. We describe this syndrome in a prehospitalized, 63-year-old patient with chronic lymphocytic leukemia and an idiopathic form of SCLS manifesting as hypovolemic shock. Initial care is hospitalization in intensive care. In addition to etiological treatment if fluid replacement is necessary, treatment must be closely monitored for secondary overload complications. Catecholamine rather than arrhythmogenic support may be associated.
authors.affiliation: Service d'Aide Médicale Urgente de la Haute Garonne (SAMU 31), Hôpital Universitaire de Purpan, place du Docteur Baylac, TSA 40031, 31059 Toulouse Cedex 9, France.
authors.forename: Manon
authors.initials: M
authors.lastname: Durand Bechu
authors.affiliation: Service d'Anesthésie-Réanimation, CHU Hôpital Rangueil, 1 avenue Jean Poulhes, TSA 50032, 31059 Toulouse Cedex 9, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Rouget
authors.affiliation: Service d'Hématologie, Pôle IUC Oncopôle, Institut Universitaire du Cancer de Toulouse, 1 avenue Irène Joliot-Curie, 31059 Toulouse Cedex 9, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Recher
authors.affiliation: Service de Réanimation Médicale, Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique, Hôpital Saint-Louis, Université Paris-Diderot, Sorbonne Paris-Cité, 1 avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Elie
authors.initials: E
authors.lastname: Azoulay
authors.affiliation: Service d'Aide Médicale Urgente de la Haute Garonne (SAMU 31), Hôpital Universitaire de Purpan, place du Docteur Baylac, TSA 40031, 31059 Toulouse Cedex 9, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Bounes