title: Intestinal transplantation.
abstract: Intestinal transplantation has now emerged as a lifesaving therapeutic option and standard of care for patients with irreversible intestinal failure. Improvement in survival over the years has justified expansion of the indications for intestinal transplantation beyond the original indications approved by Center for Medicare and Medicaid services. Management of patients with intestinal failure is complex and requires a multidisciplinary approach to accurately select candidates who would benefit from rehabilitation versus transplantation. Significant strides have been made in patient and graft survival with several advancements in the perioperative management through timely referral, improved patient selection, refinement in the surgical techniques and better understanding of the immunopathology of intestinal transplantation. The therapeutic efficacy of the procedure is well evident from continuous improvements in functional status, quality of life and cost-effectiveness of the procedure. This current review summarizes various aspects including current practices and evidence based recommendations of intestinal transplantation.
authors.affiliation: Department of Surgery, Division of Abdominal Transplantation, Duke University Medical Center, Durham, NC, USA. Electronic address: aparna.rege@duke.edu.
authors.forename: Aparna
authors.initials: A
authors.lastname: Rege
authors.affiliation: Department of Surgery, Division of Abdominal Transplantation, Duke University Medical Center, Durham, NC, USA.
authors.forename: Debra
authors.initials: D
authors.lastname: Sudan
mesh_terms: D005767:Gastrointestinal Diseases / Q000601:surgery*; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007421:Intestine, Small / Q000637:transplantation*; D016377:Organ Transplantation / Q000379:methods / Q000401:mortality; D018579:Patient Selection; D011788:Quality of Life
chemical_list: D007166:Immunosuppressive Agents
keywords: Immunosuppression; Infection; Intestinal and multi-visceral transplantation; Intestinal failure; Outcomes; Quality of life; Rejection