title: Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes.
abstract: A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.
authors.affiliation: Department of Chemistry, University of Bath, Bath BA2 7AY, UK. C.C.Wilson@bath.ac.uk.
authors.forename: Lynne H
authors.initials: LH
authors.lastname: Thomas
authors.affiliation: Department of Chemistry, University of Bath, Bath BA2 7AY, UK. C.C.Wilson@bath.ac.uk and School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Craig
authors.initials: C
authors.lastname: Wales
authors.affiliation: Department of Chemistry, University of Bath, Bath BA2 7AY, UK. C.C.Wilson@bath.ac.uk and CMAC, EPSRC Centre for Continuous Manufacturing and Crystallisation, Department of Chemistry, University of Bath, Bath BA2 7AY, UK.
authors.forename: Chick C
authors.initials: CC
authors.lastname: Wilson