title: A novel green one-step synthesis of gold nanoparticles using crocin and their anti-cancer activities.
abstract: Functionalized nanoparticles are specifically designed to deliver drugs at tumor cells and can potentially enhance anticancer activity of drugs such as crocin. In the present study, we have applied antioxidant crocin as a reducing agent for one pot green synthesis of controlled size gold nanoparticles (AuNPs). Spherical, stable and uniform AuNPs were synthesized using crocin. These AuNPs are characterized by UV-Vis, TEM and XRD techniques. The prepared AuNPs showed surface plasm on resonance centered at 520nm with the average particle size of about 4-10nm. The anti-cancer effect of AuNPs was determined using MTT and LDH tests. The cellular data showed that these AuNPs significantly decreased cancerous cells' growth after 24 and 48hours in a time- and dose-dependent manner (P<0.05). The results suggest that such AuNPs can be synthesized simply and quickly with invaluable clinical as well as pharmaceutical activities which can help to treat human breast cancer.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Electronic address: reyhaneh.houshyar@gmail.com.
authors.forename: Reyhane
authors.initials: R
authors.lastname: Hoshyar
authors.affiliation: Department of Materials Science and Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran.
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Khayati
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Poorgholami
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Kaykhaii
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D002338:Carotenoids / Q000737:chemistry*; D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D002338:Carotenoids; D006046:Gold; C029036:crocin
keywords: Breast cancer; Crocin; Gold nanoparticles