title: Which Patients With Mantle Cell Lymphoma Do Not Need Aggressive Therapy.
abstract: Mantle cell lymphoma (MCL) is a heterogeneous disease, and it has been well-established over the last decade that a subset of patients can have indolent presentation. It is therefore important to adopt a risk-stratified approach in order to minimize unnecessary toxicities while maximizing survival and quality of life in selected MCL patients. This review provides an up-to-date assessment of clinical and pathologic entities associated with indolent disease course and delineates available biomarkers with predictive significance. Initial treatment decisions should be guided by risk assessment to discern patients who might do well with deferred therapy, from those who would require treatment with non-aggressive first-line regimens.
authors.affiliation: Division of Hematology and Medical Oncology, Meyer Cancer Center, Weill Cornell Medical College, 1305 York Avenue, New York, NY, 10065, USA. jruan@med.cornell.edu.
authors.forename: Jia
authors.initials: J
authors.lastname: Ruan
authors.affiliation: Division of Hematology and Medical Oncology, Meyer Cancer Center, Weill Cornell Medical College, 1305 York Avenue, New York, NY, 10065, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Martin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D055751:SOXC Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D007143:Immunoglobulin Heavy Chains; D019394:Ki-67 Antigen; D055751:SOXC Transcription Factors; D016159:Tumor Suppressor Protein p53
keywords: Biomarkers; Hematology; Mantle cell lymphoma; Treatment