title: Circulating irisin levels reflect visceral adiposity in non-diabetic patients undergoing hemodialysis.
abstract: BACKGROUND
  Recent evidence suggests that increased visceral adiposity is a strong independent risk factor for cardiovascular death and all-cause mortality in hemodialysis (HD) patients. Irisin, which is a novel myokine, can play critical roles in diabetes and adiposity. The purpose of our study was to investigate whether serum irisin levels are associated with body mass index, waist circumference (WC), and total fat mass in non-diabetic patients undergoing maintenance HD.
  
  
  METHODS
  This cross-sectional study included 108 non-diabetic HD patients and 40 age- and sex-matched apparently healthy subjects. Serum irisin concentrations were determined using an enzyme-linked immunosorbent assay. Body fat composition (TBF-410 Tanita Body Composition Analyzer) was measured and calculated.
  
  
  RESULTS
  Serum irisin levels did not differ between HD patients and the healthy controls (523.50 ± 229.32 vs. 511.28 ± 259.74, p = 0.782). Serum irisin levels were associated with age (r = 0.314; p =0.006), HOMA-IR (r = 0.472; p = 0.003), WC (r = 0.862; p < 0.001), and total fat mass (r = 0.614; p < 0.001). In multivariate regression analysis, WC (β = 1.240, p < 0.001) and total fat mass (β = 0.792, p = 0.015) were the variables that were significantly associated with irisin concentrations (R(2 )=( )0.684, p < 0.001) after adjusting for confounding factors (age and HOMA-IR).
  
  
  CONCLUSIONS
  These results suggest that serum irisin levels are related to visceral adiposity in non-diabetic HD patients.
authors.affiliation: a Department of Internal Medicine, Section of Nephrology , Dr. A. Y. Ankara Oncology Training and Research Hospital , Ankara , Turkey ;
authors.forename: Hakki
authors.initials: H
authors.lastname: Yilmaz
authors.affiliation: b Department of Internal Medicine , Turgut Ozal University School of Medicine , Ankara , Turkey ;
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Cakmak
authors.affiliation: c Department of Internal Medicine , Ankara Atatürk Training and Research Hospital , Ankara , Turkey ;
authors.forename: Tahir
authors.initials: T
authors.lastname: Darcin
authors.affiliation: d Department of Internal Medicine , Artvin State Hospital , Artvin , Turkey ;
authors.forename: Osman
authors.initials: O
authors.lastname: Inan
authors.affiliation: e Department of Internal Medicine , Ankara Training and Research Hospital , Ankara , Turkey ;
authors.forename: Enes
authors.initials: E
authors.lastname: Sahiner
authors.affiliation: f Department of Endocrinology , Dr. A. Y. Ankara Oncology Training and Research Hospital , Ankara , Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Demir
authors.affiliation: f Department of Endocrinology , Dr. A. Y. Ankara Oncology Training and Research Hospital , Ankara , Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Aktas
authors.affiliation: b Department of Internal Medicine , Turgut Ozal University School of Medicine , Ankara , Turkey ;
authors.forename: Mukadder Ayse
authors.initials: MA
authors.lastname: Bilgic
authors.affiliation: b Department of Internal Medicine , Turgut Ozal University School of Medicine , Ankara , Turkey ;
authors.forename: Ali
authors.initials: A
authors.lastname: Akcay
mesh_terms: D050154:Adiposity; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D056128:Obesity, Abdominal / Q000097:blood*; D012044:Regression Analysis; D006435:Renal Dialysis; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: Abdominal obesity; adiposity; hemodialysis; irisin