title: Association of mannose-binding lectin levels and invasive fungal disease in hematologic malignancy patients receiving myelosuppressive chemotherapy or allogeneic hematopoietic stem cell transplantation.
abstract: Several studies have suggested an association of mannose-binding lectin (MBL) deficiency with infections. In this study, we investigated the association between MBL deficiency and invasive fungal disease (IFD) in hematologic malignancy patients receiving myelosuppressive chemotherapy or hematopoietic stem cell transplant. MBL levels were quantified at the start of treatment in 152 patients who were followed for 6 months and scored as developing IFD or not. Forty-five patients (29.6%) developed IFD, of which 21 (46.7% of IFD cases and 13.8% of patients) were proven or probable IFD. Fifty-nine (38.8%) had MBL levels <1000 ng/mL. The rates of all IFD in patients with MBL levels below and above 1000 ng/mL were 33.9% and 26.9%, respectively (P=0.356). The rates of proven or probable IFD in patients with MBL levels below and above 1000 ng/mL were 11.9% and 15.1%, respectively (P=0.579). MBL levels <1000 ng/mL were not predictors of death (P=0.233). As expected, IFD was associated with death (P<0.0001). Our findings indicate that MBL levels <1000 ng/mL were not associated with an increased risk of developing IFD or overall survival.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Riwes
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: H
authors.initials: H
authors.lastname: Leather
authors.affiliation: Department of Biostatistics, University of Florida, Gainesville, FL, USA.
authors.forename: D
authors.initials: D
authors.lastname: Neal
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: C
authors.initials: C
authors.lastname: Bennett
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sugrue
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: C
authors.initials: C
authors.lastname: Cline
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: J
authors.initials: J
authors.lastname: Stokes
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hiemenz
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hsu
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Wingard
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications* / Q000382:microbiology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000172:deficiency*; D008875:Middle Aged; D009181:Mycoses / Q000097:blood* / Q000175:diagnosis; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents; D037601:Mannose-Binding Lectin