title: Ultrastable Liquid-Liquid Interface as Viable Route for Controlled Deposition of Biodegradable Polymer Nanocapsules.
abstract: Liquid-liquid interfaces are highly dynamic and characterized by an elevated interfacial tension as compared to solid-liquid interfaces. Therefore, they are gaining an increasing interest as viable templates for ordered assembly of molecules and nanoparticles. However, liquid-liquid interfaces are more difficult to handle compared to solid-liquid interfaces; their intrinsic instability may affect the assembly process, especially in the case of multiple deposition. Indeed, some attempts have been made in the deposition of polymer multilayers at liquid-liquid interfaces, but with limited control over size and stability. This study reports on the preparation of an ultrastable liquid-liquid interface based on an O/W secondary miniemulsion and its possible use as a template for the self-assembly of polymeric multilayer nanocapsules. Such polymer nanocapsules are made of entirely biodegradable materials, with highly controlled size-well under 200 nm-and multi-compartment and multifunctional features enriching their field of application in drug delivery, as well as in other bionanotechnology fields.
authors.affiliation: Center for Advanced Biomaterials for Health Care, IIT@CRIB, Istituto Italiano di Tecnologia, Naples, Italy Via Largo Barsanti e Matteucci 53, 80125, Naples, Italy.|Interdisciplinary Research Center of Biomaterials, CRIB, University Federico II, Naples, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Vecchione
authors.affiliation: Center for Advanced Biomaterials for Health Care, IIT@CRIB, Istituto Italiano di Tecnologia, Naples, Italy Via Largo Barsanti e Matteucci 53, 80125, Naples, Italy.|Interdisciplinary Research Center of Biomaterials, CRIB, University Federico II, Naples, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Iaccarino
authors.affiliation: Department of Nanophysics, Istituto Italiano di Tecnologia (IIT), Genova, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bianchini
authors.affiliation: Department of Nanophysics, Istituto Italiano di Tecnologia (IIT), Genova, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Marotta
authors.affiliation: Department of Nanophysics, Istituto Italiano di Tecnologia (IIT), Genova, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: D'autilia
authors.affiliation: Medical Oncology, Abdominal Department, National Cancer Institute G. Pascale Foundation, Napoli, 80131, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Quagliariello
authors.affiliation: Department of Nanophysics, Istituto Italiano di Tecnologia (IIT), Genova, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Diaspro
authors.affiliation: Center for Advanced Biomaterials for Health Care, IIT@CRIB, Istituto Italiano di Tecnologia, Naples, Italy Via Largo Barsanti e Matteucci 53, 80125, Naples, Italy.|Interdisciplinary Research Center of Biomaterials, CRIB, University Federico II, Naples, Italy.
authors.forename: Paolo A
authors.initials: PA
authors.lastname: Netti
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods; D053769:Nanocapsules / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D053769:Nanocapsules; D011108:Polymers
keywords: biodegradable polymers; drug delivery; liquid-liquid interfaces; multilayer nanocapsules; ultrastable secondary miniemulsion