title: Evaluation of mediators of oxidative stress and inflammation in patients with acute appendicitis.
abstract: BACKGROUND
  This study aims to explore the potential of new inflammatory markers for improving the challenging diagnosis of acute appendicitis (AA).
  
  
  METHODS
  Levels of IL-1, IL-6, IL-8, IL-10, CRP, INF-γ, and TNF-α in serum were measured in 73 patients with AA. Oxidative stress and antioxidant enzymes were analyzed.
  
  
  RESULTS
  Serum levels of interleukins, TNF-α, and INF-γ were significantly elevated in patients with appendicitis (p < 0.0001), except for IL-10, which presented decreased levels. There were no significant differences in SOD (p = 0.29), CAT (p = 0.19), or TBARS levels (p = 0.18), whereas protein carbonyls presented significant increase (p < 0.0001).
  
  
  CONCLUSIONS
  Evaluating these biomarkers could aid in diagnosing AA.
authors.affiliation: a Department of Surgery at University Hospital of Santa Maria , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Sandra Lorena
authors.initials: SL
authors.lastname: de Oliveira Machado
authors.affiliation: b Collegiate of Medical School , Federal University of Fronteira Sul, Campus Chapecó , Brazil ;
authors.forename: Margarete Dulce
authors.initials: MD
authors.lastname: Bagatini
authors.affiliation: c Department of Biochemistry and Molecular Biology , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Pauline
authors.initials: P
authors.lastname: da Costa
authors.affiliation: c Department of Biochemistry and Molecular Biology , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Jucimara
authors.initials: J
authors.lastname: Baldissarelli
authors.affiliation: c Department of Biochemistry and Molecular Biology , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Karine Paula
authors.initials: KP
authors.lastname: Reichert
authors.affiliation: c Department of Biochemistry and Molecular Biology , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Lizielle Souza
authors.initials: LS
authors.lastname: de Oliveira
authors.affiliation: c Department of Biochemistry and Molecular Biology , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Jéssica Gonçalves
authors.initials: JG
authors.lastname: Lemos
authors.affiliation: d Department of Pharmacology , Federal University of Santa Maria , Santa Maria , Brazil.
authors.forename: Thiago
authors.initials: T
authors.lastname: Duarte
authors.affiliation: c Department of Biochemistry and Molecular Biology , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Chitolina Schetinger
authors.affiliation: c Department of Biochemistry and Molecular Biology , Federal University of Santa Maria , Santa Maria , Brazil ;
authors.forename: Vera Maria
authors.initials: VM
authors.lastname: Morsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001064:Appendicitis / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Cytokines; growth factors; inflammatory bowel disease; inflammatory mediators; oxidative stress