title: [Klatskin tumor: long-term survival following surgery].
abstract: BACKGROUND
  Perihilar cholangiocarcinoma (Klatskin tumor) is a rare tumor entity with an unfavorable prognosis despite optimal treatment.
  
  
  OBJECTIVE
  The aim of the study is to investigate beneficial histopathological features and recommendations for surgery in perihilar cholangiocarcinoma to improve patients' long term survival.
  
  
  METHODS
  192 patients suffering from perihilar cholangiocarcinoma underwent attempted tumor resection between 1998 and 2008 at our clinic. 50 patients survived more than 2 years. The follow-up ended in December 2013. The resection type, the UICC stage and histopathological features were compared between three groups (2-3-year, 3-5-year and > 5-year survival groups).
  
  
  RESULTS
  The overall 5‑year survival rate of the study groups was 32 %, and even 16 % survived more than 10 years after surgery. Patients with lymph node positive tumors (p = 0.0126) and distant metastasis (p = 0.0376) had the poorest survival rate. Perineural invasion had no significant impact on the overall survival, but patients surviving more than 5 years had the lowest incidence of perineural invasion with 18.75 %. Caudate lobectomy was significantly (p = 0.011) associated with a survival of more than 5 years in our study.
  
  
  CONCLUSIONS
  Complete tumor resection with additional caudate lobe resection is associated with long-term survival. Perineural invasion seems to be a negative prognostic factor for long-term survival.
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, Essen, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Juntermanns
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, Essen, Deutschland.
authors.forename: C D
authors.initials: CD
authors.lastname: Fingas
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, Essen, Deutschland.
authors.forename: G C
authors.initials: GC
authors.lastname: Sotiropoulos
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, Essen, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Jaradat
authors.affiliation: Klinik für Gastroenterologie und Hepatologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Dechêne
authors.affiliation: Institut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Reis
authors.affiliation: Innere Klinik (Tumorforschung), Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Kasper
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, Essen, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Paul
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, Essen, Deutschland. gernot.kaiser@st-bernhard-hospital.de.|Klinik für Allgemein- und Viszeralchirurgie, St. Bernhard-Hospital Kamp-Lintfort, Bürgermeister-Schmelzing-Str. 90, 47475, Kamp-Lintfort, Deutschland. gernot.kaiser@st-bernhard-hospital.de.
authors.forename: G M
authors.initials: GM
authors.lastname: Kaiser
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D001652:Bile Ducts / Q000473:pathology; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D018285:Klatskin Tumor / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis
keywords: Klatskin-tumor; Lobus caudatus resection; Perihilar cholangiocarcinoma; Perineural tumor invasion; Surgical strategy