title: Hepatoid Adenocarcinoma of the Duodenum: An Unusual Location.
abstract: Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor distinguished by having both hepatoid and adenomatous features, which can make the diagnosis challenging. Although it mostly originates in the stomach, several other sites of origin have been reported. We report a case of HAC originating in the duodenum, a very unusual location. We also discuss an approach to the diagnosis of HAC using morphological and immunohistochemical features, and explore possible therapeutic options.
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Howard University Hospital, Washington, D.C., USA.
authors.forename: Onyekachi Henry
authors.initials: OH
authors.lastname: Ogbonna
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Howard University Hospital, Washington, D.C., USA.
authors.forename: Susmita
authors.initials: S
authors.lastname: Sakruti
authors.affiliation: Departments of Internal Medicine, Howard University Hospital, Washington, D.C., USA.
authors.forename: Maha
authors.initials: M
authors.lastname: Sulieman
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Howard University Hospital, Washington, D.C., USA.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ali
authors.affiliation: Pathology, Howard University Hospital, Washington, D.C., USA.
authors.forename: Babak
authors.initials: B
authors.lastname: Shokrani
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Howard University Hospital, Washington, D.C., USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Oneal
keywords: Carcinoembryonic antigen; Chemotherapy; Duodenum; Hepatoid adenocarcinoma; Immunohistochemistry; Morphology; α-Fetoprotein