title: Ag Nanoparticles-enhanced Fluorescence of Terbium-Deferasirox Complexes for the Highly Sensitive Determination of Deferasirox.
abstract: We describe the effect of different sized gold and silver nanoparticles on the terbium sensitized fluorescence of deferasirox. It is indicated that silver nanostructures, especially 18 nm Ag nanoparticles (AgNPs), have a remarkable amplifying effect compared to Au nanoparticles. Based on this observation, a highly sensitive and selective method was developed for the determination of deferasirox. Effects of various parameters like AgNPs and Tb(3+) concentration and pH of media were investigated. Under the optimal conditions, a calibration curve was plotted as the fluorescence intensities versus the concentration of deferasirox in the range of 0.1 to 200 nmol L(-1), and detection limit of 0.03 nmol L(-1) was obtained. The method has good linearity, recovery, reproducibility and sensitivity, and was satisfactorily applied for the determination of deferasirox in urine and pharmaceutical samples.
authors.affiliation: Department of Chemistry, Tabriz Branch, Islamic Azad University.
authors.forename: Jafar
authors.initials: J
authors.lastname: Abolhasani
authors.forename: Roza
authors.initials: R
authors.lastname: Naderali
authors.forename: Javad
authors.initials: J
authors.lastname: Hassanzadeh
mesh_terms: D001565:Benzoates / Q000032:analysis* / Q000737:chemistry*; D000077588:Deferasirox; D005453:Fluorescence; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D012834:Silver / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013607:Tablets; D013725:Terbium / Q000737:chemistry*; D014230:Triazoles / Q000032:analysis* / Q000737:chemistry*
chemical_list: D001565:Benzoates; D013607:Tablets; D014230:Triazoles; D013725:Terbium; D012834:Silver; D000077588:Deferasirox