title: Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells.
abstract: BACKGROUND
  Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells.
  
  
  OBJECTIVE
  To investigate the anticancer activity of DHA on CNE-2 cells.
  
  
  METHODS
  Cell cycleand invasion assay were used to detect the effect of DHA on CNE-2 cells. Protein molecular differences were examined by Western blot.
  
  
  RESULTS
  DHA strongly inhibited cell proliferation by induced cell cycle G1 arrest and apoptosis in CNE-2 cells. In addition, cell motility, invasion, and colony formation were suppressed by DHA.
  
  
  CONCLUSIONS
  DHA shows significant anticancer effects on human NPC cells, and may be a preventive and therapeutic agent against NPC.
authors.forename: Zhenhe
authors.initials: Z
authors.lastname: Huang
authors.forename: Xueqin
authors.initials: X
authors.lastname: Huang
authors.forename: Donghui
authors.initials: D
authors.lastname: Jiang
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.affiliation: The First Affiliated Hospital of Guangdong Medical College; Department of Otolaryngology, Guangdong Medical College, Zhanjiang, Guangdong, 524023, China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Luo
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D037621:Artemisinins / Q000008:administration & dosage*; D002277:Carcinoma; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D037621:Artemisinins; C039060:artenimol