title: Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles.
abstract: Electrophilic activation of alkynylphosphine oxides and phosphonates provides a novel approach to the synthesis of P-substituted and P-centered heterocycles. Iodocyclization affords a heteroaryl iodide that can, among other things, be used in reiterative alkyne coupling and iodocyclization to give cyclic phosphonates and other cyclization reactions to give π-rich P-heterocycles.
authors.affiliation: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, 3052 Victoria, Australia.
authors.forename: Akhil
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, 3052 Victoria, Australia.
authors.forename: Bernard L
authors.initials: BL
authors.lastname: Flynn