title: Cardiovascular disease risk in individuals with chronic spinal cord injury: Prevalence of untreated risk factors and poor adherence to treatment guidelines.
abstract: Cardiovascular disease (CVD) is currently the leading cause of mortality among individuals living with chronic spinal cord injury (SCI). The purpose of this study is to: 1) Describe the prevalence of CVD risk factors including dyslipidemia (DYS), hypertension (HTN) and type II diabetes mellitus (DM) in patients with chronic SCI; 2) Report the frequency of individuals recommended for diagnostic testing, as per current Canadian CVD diagnostic guidelines; and 3) Report the frequency of individuals receiving guideline-derived appropriate therapy for these risk factors.
  
  
  
  Adults with a chronic, stable SCI (n = 91) were included in this study. Medical histories, current medications, blood serum analyses and blood pressures were collected and compared to current Canadian CVD diagnostic guidelines to assess for DYS, HTN and DM.
  
  
  
  Of the 81 participants with blood serum analyses, 10 (14.7%) of 23 (28.4%) individuals meeting diagnostic criteria for DYS were not taking appropriate statin medication and 2 (2.5%) of 7 (8.6%) individuals meeting diagnostic criteria for DM were not taking appropriate DM medication. Of the 91 participants having BP measurements, 13 (14.3%) of 26 (28.6%) individuals meeting diagnostic criteria for HTN were not taking appropriate BP medication.
  
  
  
  In addition to a high prevalence of CVD risk factors among individuals with chronic SCI, there is also evidence of poor adherence to diagnostic and treatment guidelines for DYS, HTN and DM. The study results highlight an important gap between the observed prevalence of disease and the low rates of screening and guideline adherence in the SCI population.
authors.affiliation: a Institute of Medical Science , University of Toronto , Toronto , Canada.
authors.forename: Amit S
authors.initials: AS
authors.lastname: Chopra
authors.affiliation: b Toronto Rehabilitation Institute-UHN , Brain and Spinal Cord Rehabilitation Program , Toronto , Canada.
authors.forename: Masae
authors.initials: M
authors.lastname: Miyatani
authors.affiliation: b Toronto Rehabilitation Institute-UHN , Brain and Spinal Cord Rehabilitation Program , Toronto , Canada.|c Department of Medicine , University of Toronto , Toronto , Canada.
authors.forename: B Catharine
authors.initials: BC
authors.lastname: Craven
mesh_terms: D000328:Adult; D000368:Aged; D002170:Canada; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D019983:Guideline Adherence; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance; D015995:Prevalence; D013119:Spinal Cord Injuries / Q000453:epidemiology* / Q000628:therapy
keywords: Cardiovascular disease; Diabetes mellitus; Dyslipidemia; Hypertension; Spinal cord injury