title: Analgesic, anti-inflammatory and anti-pyretic activities of Thymus linearis.
abstract: The present study was aimed to investigate the antipyretic, analgesic and anti-inflammatory activity of aqueous methanolic and n-hexane extract of Thymus linearis. For measuring analgesic activity, writhing test, hot plate method and formalin test were performed and abdominal writhing was induced by intra-peritoneal injection of 0.2 ml of 3% acetic acid. While in formalin test, pain was experimentally induced by injecting 25 μl of 2.5% formalin in left hind paw. In hot plate method, pain was induced thermally by keeping the animals on a hot plate with temperature of about 51°C. Anti-inflammatory activity was assessed by carrageenan induced mice paw edema. For determination of antipyretic activity, pyrexia was induced by subcutaneous injection of 15% yeast. The results showed that both the extracts had significant analgesic activity (p<0.05); anti-inflammatory activity (p<0.05) and anti-pyretic activity (p<0.05). Therefore, it was concluded from this study that the extracts of Thymus linearis may be used against pain, pyrexia and inflammation.
authors.affiliation: Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Qadir
authors.affiliation: Faculty of Pharmaceutical Sciences & Government College University, Faisalabad, Pakistan.
authors.forename: Amna
authors.initials: A
authors.lastname: Parveen
authors.affiliation: Faculty of Pharmaceutical Sciences & Government College University, Faisalabad, Pakistan.
authors.forename: Khizar
authors.initials: K
authors.lastname: Abbas
authors.affiliation: -
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D058633:Antipyretics / Q000302:isolation & purification / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects; D004195:Disease Models, Animal; D005334:Fever / Q000382:microbiology / Q000503:physiopathology / Q000517:prevention & control*; D006586:Hexanes / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D000432:Methanol / Q000737:chemistry; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D017288:Pain Threshold / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D012997:Solvents / Q000737:chemistry; D046930:Thymus Plant / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D006586:Hexanes; D010936:Plant Extracts; D012997:Solvents; C026385:n-hexane; D000432:Methanol