title: Portable X-ray fluorescence spectroscopy as a rapid screening technique for analysis of TiO2and ZnO in sunscreens.
abstract: This investigation reports a rapid and simple screening technique for the quantification of titanium and zinc in commercial sunscreens using portable X-ray fluorescence spectroscopy (pXRF). A highly evolved technique, inductively coupled plasma-mass spectroscopy (ICP-MS) was chosen as a comparative technique to pXRF, and a good correlation (r2> 0.995) with acceptable variations (≤25%) in results between both techniques was observed. Analytical figures of merit such as detection limit, quantitation limit, and linear range of the method are reported for the pXRF technique. This method has a good linearity (r2> 0.995) for the analysis of titanium (Ti) in the range of 0.4-14.23 wt%, and zinc (Zn) in the range of 1.0-23.90 wt%. However, most commercial sunscreens contain organic ingredients, and these ingredients are known to cause matrix effects. The development of appropriate matrix matched working standards to obtain the calibration curve was found to be a major challenge for the pXRF measurements. In this study, we have overcome the matrix effect by using metal-free commercial sunscreens as a dispersing media for the preparation of working standards. An easy extension of this unique methodology for preparing working standards in different matrices was also reported. This method is simple, rapid, and cost-effective and, in comparison to conventional techniques (e.g., ICP-MS), did not generate toxic wastes during sample analysis.
authors.affiliation: Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States.
authors.forename: Venu Gopal
authors.initials: VG
authors.lastname: Bairi
authors.affiliation: Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Lim
authors.affiliation: Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States.
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Quevedo
authors.affiliation: Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States.
authors.forename: Thilak K
authors.initials: TK
authors.lastname: Mudalige
authors.affiliation: Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States.
authors.forename: Sean W
authors.initials: SW
authors.lastname: Linder
keywords: Inductively coupled plasma-mass spectrometry; Metals; Portable x-ray fluorescence spectroscopy analyzer; Quantitation; Sunscreens