title: Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer.
abstract: OBJECTIVE
  The aim was to explore the structure and functions of new target spot c-Myc target from laryngeal cancer cell. (MTLC) of c-Myc gene.
  
  
  METHODS
  This study adopted bioinformatic methods to analyze the physicochemical property, secondary structure, hydrophobic region, a transmembrane region, and prediction of functions.
  
  
  RESULTS
  The results showed that the whole length of the open reading frames was 708 bp, coding was 235 amino acids. This protein was a basic protein possessed two transmembrane structures and weight was about 26592.5 Da. The main elements of secondary structure were alpha-helix and random coil. MTLC was a membrane constitutive protein that possessed signal transduction and regulation may locate on karyotheca as results of subcellular localization and function prediction.
  
  
  CONCLUSIONS
  This study has provided the theoretical basis for the further discussion of the effect and mechanism of action of MTLC in the occurrence of laryngeal cancer.
authors.affiliation: Department of Otorhinolaryngology, People's Hospital of Zhengzhou, Henan, Henan Province, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: He-Xin
authors.initials: HX
authors.lastname: Chen
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Wang
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Chen
authors.forename: Zhong-Jie
authors.initials: ZJ
authors.lastname: Shan
authors.forename: Guang
authors.initials: G
authors.lastname: Xu
mesh_terms: D019295:Computational Biology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D007830:Larynx / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry* / Q000378:metabolism
chemical_list: C489427:MYC protein, human; C477074:MYCT1 protein, human; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc