title: Effective Chemical Inactivation of Ebola Virus.
abstract: Reliable inactivation of specimens before removal from high-level biocontainment is crucial for safe operation. To evaluate efficacy of methods of chemical inactivation, we compared in vitro and in vivo approaches using Ebola virus as a surrogate pathogen. Consequently, we have established parameters and protocols leading to reliable and effective inactivation.
authors.forename: Elaine
authors.initials: E
authors.lastname: Haddock
authors.forename: Friederike
authors.initials: F
authors.lastname: Feldmann
authors.forename: Heinz
authors.initials: H
authors.lastname: Feldmann
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D004202:Disinfectants / Q000494:pharmacology*; D029043:Ebolavirus / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D014709:Vero Cells; D038301:Virus Inactivation / Q000187:drug effects*
chemical_list: D004202:Disinfectants
keywords: Ebola virus; chemical inactivation; mouse model; tissue culture; viruses