title: Compressive, diametral tensile and biaxial flexural strength of cutting-edge calcium phosphate cements.
abstract: Calcium phosphate cements (CPCs) are widely used in bone repair. Currently there are two main types of CPCs, brushite and apatite. The aim of this project was to evaluate the mechanical properties of particularly promising experimental brushite and apatite formulations in comparison to commercially available brushite- and apatite-based cements (chronOS(™) Inject and Norian(®) SRS(®), respectively), and in particular evaluate the diametral tensile strength and biaxial flexural strength of these cements in both wet and dry conditions for the first time. The cements׳ porosity and their compressive, diametral tensile and biaxial flexural strength were tested in wet (or moist) and dry conditions. The surface morphology was characterized by scanning electron microscopy. Phase composition was assessed with X-ray diffraction. It was found that the novel experimental cements showed better mechanical properties than the commercially available cements, in all loading scenarios. The highest compressive strength (57.2±6.5MPa before drying and 69.5±6.0MPa after drying) was found for the experimental brushite cement. This cement also showed the highest wet diametral tensile strength (10.0±0.8MPa) and wet biaxial flexural strength (30.7±1.8MPa). It was also the cement that presented the lowest porosity (approx. 12%). The influence of water content was found to depend on cement type, with some cements showing higher mechanical properties after drying and some no difference after drying.
authors.affiliation: Materials in Medicine, Division of Applied Materials Sciences, Department of Engineering Sciences, Uppsala University, Box 534, 751 21 Uppsala, Sweden.
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.affiliation: Materials in Medicine, Division of Applied Materials Sciences, Department of Engineering Sciences, Uppsala University, Box 534, 751 21 Uppsala, Sweden.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Ajaxon
authors.affiliation: Research Centre in Biomedical Engineering, Biomaterials Division, Department of Materials Science and Metallurgy, Technical University of Catalonia (UPC), Av. Diagonal 647, E08028 Barcelona, Spain.
authors.forename: Maria Pau
authors.initials: MP
authors.lastname: Ginebra
authors.affiliation: Materials in Medicine, Division of Applied Materials Sciences, Department of Engineering Sciences, Uppsala University, Box 534, 751 21 Uppsala, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Engqvist
authors.affiliation: Materials in Medicine, Division of Applied Materials Sciences, Department of Engineering Sciences, Uppsala University, Box 534, 751 21 Uppsala, Sweden. Electronic address: cecilia.persson@angstrom.uu.se.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Persson
mesh_terms: D001843:Bone Cements; D002130:Calcium Phosphates; D019245:Compressive Strength; D008422:Materials Testing; D013718:Tensile Strength
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates
keywords: Apatite; Brushite; Calcium phosphate cement; Compressive strength; Flexural strength; Tensile strength