title: Contribution of ¹⁸Fluorodeoxyglucose positron emission tomography uptake and TTF-1 expression in the evaluation of the EGFR mutation in patients with lung adenocarcinoma.
abstract: OBJECTIVE
  The aim of this study is to evaluate the diagnostic value of PET-CT scan for the prediction of EGFR mutation status and the contribution of TTF-1 expression to PET-CT scan.
  
  
  METHODS
  We retrospectively studied 218 cases with a diagnosis of pulmonary adenocarcinoma between 2012-2014 which underwent EGFR analysis, TTF-1 and PET-CT before treatment.
  
  
  RESULTS
  The EGFR mutation was present in 28.9% (n= 63) of cases. TTF-1 positivity was 66.9% (n= 105). Standardized uptake value (SUV max) was 16.7 ± 6.8 in EGFR mutant type, 13.8 ± 7.6 in cases having no EGFR mutations. According to our evaluations, high SUVmax is positively correlated with EGFR mutation status. TTF-1 expression in multivariate analysis strengthens the accuracy of detecting an EGFR mutation.
  
  
  CONCLUSIONS
  PET-CT FDG uptake may, together with TTF-1 expression, help diagnosis in lung adenocarcinoma cases when evaluating for EGFR mutation status.
authors.affiliation: Yedikule Chest Diseases Research and Training Hospital, Istanbul, Turkey.
authors.forename: Zehra Dilek
authors.initials: ZD
authors.lastname: Kanmaz
authors.affiliation: Yedikule Chest Diseases Research and Training Hospital, Istanbul, Turkey.
authors.forename: Gülfidan
authors.initials: G
authors.lastname: Aras
authors.affiliation: Yedikule Chest Diseases Research and Training Hospital, Istanbul, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Tuncay
authors.affiliation: Yedikule Chest Diseases Research and Training Hospital, Istanbul, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Bahadır
authors.affiliation: Yedikule Chest Diseases Research and Training Hospital, Istanbul, Turkey.
authors.forename: Celalettin
authors.initials: C
authors.lastname: Kocatürk
authors.affiliation: Abant Izzet Baysal University School of Medicine, Istanbul, Turkey.
authors.forename: Zehra Asuk
authors.initials: ZA
authors.lastname: Yaşar
authors.affiliation: Cerrahpasa Medical Faculty, Pathology Department Istanbul University, Istanbul, Turkey.
authors.forename: Büge
authors.initials: B
authors.lastname: Öz
authors.affiliation: Cerrahpasa Medical Faculty, Pathology Department Istanbul University, Istanbul, Turkey.
authors.forename: Canan Ünlü
authors.initials: CÜ
authors.lastname: Özkurt
authors.affiliation: Department of Nuclear Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Gündoğan
authors.affiliation: Department of Nuclear Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tevfik Fikret
authors.initials: TF
authors.lastname: Çermik
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D001483:Base Sequence; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009687:Nuclear Proteins / Q000378:metabolism*; D000072078:Positron Emission Tomography Computed Tomography; D012189:Retrospective Studies; D017422:Sequence Analysis, DNA; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D019788:Fluorodeoxyglucose F18; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: EGFR; Lung cancer; TTF-1