title: The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection.
abstract: Salmonella enterica Typhimurium employs type III secreted effectors to induce cellular invasion and pathogenesis. We previously reported the secreted effector SipA is in part responsible for inducing the apical accumulation of the host membrane protein PERP, a host factor we have shown is key to the inflammatory response induced by Salmonella. We now report that the S. Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface. To our knowledge, this is the first report demonstrating a role for SipC in directing the trafficking of a host membrane protein to the cell surface. In sum, facilitation of PERP trafficking appears to be a result of type III secreted effector-mediated recruitment of vesicles to the apical surface. Our study therefore reveals a new role for SipC, and builds upon previous reports suggesting recruitment of vesicles to the cell surface is important for Salmonella invasion.
authors.affiliation: a Department of Microbiology and Physiological Systems , University of Massachusetts Medical School , Worcester , MA , USA.
authors.forename: Kelly N
authors.initials: KN
authors.lastname: Hallstrom
authors.affiliation: a Department of Microbiology and Physiological Systems , University of Massachusetts Medical School , Worcester , MA , USA.
authors.forename: Beth A
authors.initials: BA
authors.lastname: McCormick
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D054884:Host-Pathogen Interactions; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D012480:Salmonella Infections / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism*; D000069296:Type III Secretion Systems / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; C416404:PERP protein, human; C094578:Salmonella invasion protein C; D000069296:Type III Secretion Systems
keywords: Salmonella; host pathogen interactions; inflammation; trafficking; type III secretion