title: Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia.
abstract: Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg(2+) , can be a severe side effect of chronic PPI use.
  
  
  
  To restore serum Mg(2+) concentrations in PPI-induced hypomagnesaemia patients by dietary supplementation with inulin fibres.
  
  
  
  Eleven patients with PPI-induced hypomagnesaemia and 10 controls were treated with inulin (20 g/day). Each trial consisted of two cycles of 14-day inulin treatment followed by a washout period of 14 days. Patients continued to use their PPI. Serum Mg(2+) levels served as the primary endpoint.
  
  
  
  Inulin significantly enhanced serum Mg(2+) levels from 0.60 to 0.68 mmol/L in PPI-induced hypomagnesaemia patients, and from 0.84 to 0.93 mmol/L in controls. As a consequence 24 h urinary Mg(2+) excretion was significantly increased in patients with PPI-induced hypomagnesaemia (0.3-2.2 mmol/day). Symptoms related to hypomagnesaemia, including muscle cramps and paraesthesia, were reduced during intervention with inulin.
  
  
  
  Inulin increases serum Mg(2+) concentrations under PPI maintenance in patients with PPI-induced hypomagnesaemia.
authors.affiliation: Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: M W
authors.initials: MW
authors.lastname: Hess
authors.affiliation: Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: J H F
authors.initials: JH
authors.lastname: de Baaij
authors.affiliation: Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Broekman
authors.affiliation: Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: T M
authors.initials: TM
authors.lastname: Bisseling
authors.affiliation: Department of Gastroenterology, Bernhoven Hospital, Uden, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Haarhuis
authors.affiliation: Department of Gastroenterology, Canisius-Wilhelmina-Hospital, Nijmegen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Tan
authors.affiliation: Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Te Morsche
authors.affiliation: Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: J G J
authors.initials: JG
authors.lastname: Hoenderop
authors.affiliation: Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: R J M
authors.initials: RJ
authors.lastname: Bindels
authors.affiliation: Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: J P H
authors.initials: JP
authors.lastname: Drenth
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007444:Inulin / Q000008:administration & dosage*; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000097:blood; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000188:drug therapy; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors; D007444:Inulin; D008274:Magnesium