title: HIV-1 gp120-Mediated Mitochondrial Dysfunction and HIV-Associated Neurological Disorders.
abstract: The treatment of HIV infection presents a great challenge among the patients who develop various forms of cognitive impairments. Particularly, the neurotoxicity associated with HIV is attributed to different viral proteins present in HIV, and is a root cause for HIV-associated neurocognitive disorders (HAND). A common characteristic among several neurodegenerative disorders including HAND is mitochondrial dysfunction in various brain cells. However, there has been very little effort to explore the possibility of exploiting mitochondrial dynamics in HAND treatment. A recent study by Avdoshina and colleagues has reported the role of mitochondrial dysfunction in HIV-1 gp120-mediated neuronal dysfunction, which presents a novel mechanism for the development of adjunct therapy to treat HAND.
authors.affiliation: Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO, 64108, USA.
authors.forename: Ankit
authors.initials: A
authors.lastname: Shah
authors.affiliation: Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO, 64108, USA. kumaran@umkc.edu.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
mesh_terms: D001921:Brain; D015699:HIV Envelope Protein gp120; D015658:HIV Infections; D015497:HIV-1; D006801:Humans; D009422:Nervous System Diseases
chemical_list: D015699:HIV Envelope Protein gp120
keywords: HIV-1; Mitochondrial stress; Neurons; gp120