title: N-Heterocyclic Carbene-Catalyzed Convenient Benzonitrile Assembly.
abstract: The benzonitrile unit is widely found in natural products, pharmaceuticals, and agrochemicals. Synthesis of benzonitriles has received considerable interests from the chemical community over the last few decades. Present synthetic protocols mainly rely on the pre-existing benzene core to install a cyano moiety. A new NHC-catalyzed [4 + 2]-benzannulation protocol is reported to assemble the benzonitrile framework.
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 117543, China.
authors.forename: Qianfa
authors.initials: Q
authors.lastname: Jia
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 117543, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang