title: Parietal Fast Sleep Spindle Density Decrease in Alzheimer's Disease and Amnesic Mild Cognitive Impairment.
abstract: Several studies have identified two types of sleep spindles: fast (13-15 Hz) centroparietal and slow (11-13 Hz) frontal spindles. Alterations in spindle activity have been observed in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). Only few studies have separately assessed fast and slow spindles in these patients showing a reduction of fast spindle count, but the possible local specificity of this phenomenon and its relation to cognitive decline severity are not clear. Moreover, fast and slow spindle density have never been assessed in AD/MCI. We have assessed fast and slow spindles in 15 AD patients, 15 amnesic MCI patients, and 15 healthy elderly controls (HC). Participants underwent baseline polysomnographic recording (19 cortical derivations). Spindles during nonrapid eye movements sleep were automatically detected, and spindle densities of the three groups were compared in the derivations where fast and slow spindles exhibited their maximum expression (parietal and frontal, resp.). AD and MCI patients showed a significant parietal fast spindle density decrease, positively correlated with Minimental State Examination scores. Our results suggest that AD-related changes in spindle density are specific for frequency and location, are related to cognitive decline severity, and may have an early onset in the pathology development.
authors.affiliation: Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gorgoni
authors.affiliation: Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Lauri
authors.affiliation: Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Truglia
authors.affiliation: Department of Physiology and Pharmacology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Cordone
authors.affiliation: Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, 20157 Milan, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Sarasso
authors.affiliation: Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Scarpelli
authors.affiliation: Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Mangiaruga
authors.affiliation: Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Aurora
authors.initials: A
authors.lastname: D'Atri
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Tempesta
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 Coppito, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Ferrara
authors.affiliation: Institute of Neurology, Catholic University of The Sacred Heart, 00168 Rome, Italy.
authors.forename: Camillo
authors.initials: C
authors.lastname: Marra
authors.affiliation: Institute of Neurology, Catholic University of The Sacred Heart, 00168 Rome, Italy; IRCCS San Raffaele Pisana, 00163 Rome, Italy.
authors.forename: Paolo Maria
authors.initials: PM
authors.lastname: Rossini
authors.affiliation: Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: De Gennaro
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology; D000647:Amnesia / Q000503:physiopathology* / Q000523:psychology; D001288:Attention / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012890:Sleep / Q000502:physiology*