title: Adipose-derived Stem Cells Added to Platelet-rich Plasma for Chronic Skin Ulcer Therapy.
abstract: BACKGROUND
  Adipose-derived stem cells (ASCs) hold great promise for regenerative medicine applications due to their ability to promote the healing process through in situ differentiation and secretion of paracrine factor. The aim of this paper is to present a clinical adjunct for chronic skin wound therapy based on ASCs added to platelet-rich plasma (PRP), to obtain an enhanced PRP (e-PRP).
  
  
  METHODS
  For 18 months, 24 control-group patients with 31 chronic skin ulcers were treated with standard wound care, while 16 experimental-group patients with 21 chronic skin ulcers were treated with standard wound care and 1 e-PRP injection. The patients were randomly assigned to the control or experimental group. Outpatients had weekly follow-up visits where they were subjected to standard treatment and the wound healing process was assessed.
  
  
  RESULTS
  At the end of the study, the control and experimental groups had similar healing rates but wound closure rates were significantly different (P = 0.0257): 0.0890 cm(2) x day and 0.2287 cm(2) x day respectively, resulting in a faster recovery for the group treated with e-PRP. No side effects were reported.
  
  
  CONCLUSIONS
  In the authors' experience, e-PRP significantly enhanced wound closure rates when compared to standard wound care, without causing any serious complications. This finding highlights e-PRP as a valuable resource for chronic wound treatment.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Raposio
authors.forename: Nicolò
authors.initials: N
authors.lastname: Bertozzi
authors.forename: Sabrina
authors.initials: S
authors.lastname: Bonomini
authors.forename: Gino
authors.initials: G
authors.lastname: Bernuzzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Formentini
authors.forename: Eugenio
authors.initials: E
authors.lastname: Grignaffini
authors.forename: Michele
authors.initials: M
authors.lastname: Pio Grieco
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma; D044968:Regenerative Medicine / Q000379:methods*; D012883:Skin Ulcer / Q000628:therapy*; D013234:Stem Cells; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*