title: Decreased left atrial strain parameters are correlated with prolonged total atrial conduction time in lone atrial fibrillation.
abstract: To investigate left atrium (LA) strain properties of patients with lone atrial fibrillation (LAF) and to assess relationships between LA strain parameters and total atrial conduction time measured with tissue Doppler imaging (PA-TDI). The study population consisted of 53 patients with LAF. The control group was comprised of 50 normal volunteers. Conventional echocardiography indices were measured. Mitral annular velocities and PA-TDI were assessed with TDI. Two-dimensional speckle-tracking echocardiography (2D-STE) was used to assess LA segmental strain and strain rate. Compared with the control group, PA-TDI was significantly prolonged and LA myocardial Ss, SRs, Sa, and SRa were significantly decreased in the LAF group (all P < 0.001). In the control group, LA myocardial Ss (γ = -0.486, P < 0.01), SRs (γ = -0.436, P < 0.01), and Sa (γ = -0.360, P < 0.05) were correlated negatively with PA-TDI. LA myocardial SRa (γ = 0.377, P < 0.01) was correlated positively with PA-TDI. In the LAF group, LA myocardial Ss (γ = -0.429, P < 0.01), SRs (γ = -0.468, P < 0.01), and Sa (γ = -0.380, P < 0.05) were also correlated negatively, and SRa (γ = 0.390, P < 0.01) was correlated positively, with PA-TDI. Multivariate logistic regression identified PA-TDI as the only predictor of AF onset (OR 1.39; 95 % CI 1.02-1.54; P < 0.01). LA strain parameters were decreased and PA-TDI was prolonged in patients with LAF. Structural remodeling of the LA, assessed by 2D-STE, was correlated with electrical remodeling, determined by PA-TDI. Prolonged PA-TDI was independently associated with AF onset.
authors.affiliation: Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Guo
authors.affiliation: Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. jiexin_liu@sina.com.
authors.forename: Jiexin
authors.identifier: http://orcid.org/0000-0002-9296-2957
authors.initials: J
authors.lastname: Liu
authors.affiliation: Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Yixing
authors.initials: Y
authors.lastname: Teng
authors.affiliation: Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Luhua
authors.initials: L
authors.lastname: Shen
mesh_terms: D000200:Action Potentials; D000328:Adult; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016279:Atrial Function, Left; D064752:Atrial Remodeling; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006339:Heart Rate; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D015999:Multivariate Analysis; D015588:Observer Variation; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013314:Stress, Mechanical; D013997:Time Factors
keywords: Lone atrial fibrillation; Strain; Total atrial conduction time