title: Eosinophilia in Preterm Born Infants Infected with Chlamydia trachomatis.
abstract: A higher than 350 eosinophils/mm(3) is strongly associated with Chlamydia trachomatis in term born babies coursing with respiratory distress. However, in preterm newborns infected with this pathogen, the levels of eosinophils are unknown. Forty newborn infants with clinical data of respiratory problems and/or sepsis were analyzed. DNA of leukocytes from peripheral blood was used to identify C. trachomatis. Detection of chlamydial infection was performed by amplifying the ompA gene by an in-house PCR, and eosinophil levels were evaluated in an XT-2000-hematology analyzer. Eighteen infants showed chlamydial infection and 14 of them showed pneumonia (RR = 2.6; CI95% 1.03-6.5; p =.027). Their eosinophil levels were 719 ± 614 cells/mm(3). A significant association between eosinophilia ≥1250 cells/mm(3) and gestational age of less than 29 weeks (RR = 5.8; 1.35; CI95% [1.4-24.5], p <.008) was observed. The preterm infants with chlamydial infection did not show higher eosinophil levels than uninfected infants.
authors.affiliation: a National Institute of Perinatology, Infectology , Montes Urales 800, Col Lomas Virreyes, Mexico City , 11000 Mexico.
authors.forename: Marcela
authors.initials: M
authors.lastname: López-Hurtado
authors.affiliation: a National Institute of Perinatology, Infectology , Montes Urales 800, Col Lomas Virreyes, Mexico City , 11000 Mexico.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Arteaga-Troncoso
authors.affiliation: a National Institute of Perinatology, Infectology , Montes Urales 800, Col Lomas Virreyes, Mexico City , 11000 Mexico.
authors.forename: Irma E
authors.initials: IE
authors.lastname: Sosa-González
authors.affiliation: b National School of Biological Sciences, Microbiology, Prol. de Carpio y Plan de Ayala , Mexico City , 11340 Mexico.
authors.forename: Maria de Jesus
authors.initials: Mde J
authors.lastname: de Haro-Cruz
authors.affiliation: a National Institute of Perinatology, Infectology , Montes Urales 800, Col Lomas Virreyes, Mexico City , 11000 Mexico.
authors.forename: Veronica R
authors.initials: VR
authors.lastname: Flores-Salazar
authors.affiliation: a National Institute of Perinatology, Infectology , Montes Urales 800, Col Lomas Virreyes, Mexico City , 11000 Mexico.|b National School of Biological Sciences, Microbiology, Prol. de Carpio y Plan de Ayala , Mexico City , 11340 Mexico.
authors.forename: Fernando Martín
authors.initials: FM
authors.lastname: Guerra-Infante
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D002692:Chlamydia trachomatis; D004802:Eosinophilia / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011014:Pneumonia / Q000382:microbiology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D018805:Sepsis / Q000382:microbiology / Q000473:pathology; D055815:Young Adult
keywords: Chlamydia trachomatis; eosinophilia; pneumonia; preterm newborn; sepsis