title: Understanding dendritic cell immunotherapy in ovarian cancer.
abstract: BACKGROUND
  Approximately eighty percent of patients with ovarian cancer are diagnosed with advanced disease. Even with cutting edge surgical techniques and the best regimens of standard therapies most patients relapse and die of drug resistant disease within five years of diagnosis. Dendritic cell (DC) immunotherapy can induce anti-tumor T cell immunity in patients and holds great potential in the era of modern anti-cancer treatment.
  
  
  METHODS
  This review outlines critical factors regulating the outcome of DC immunotherapy in ovarian cancer, summarizes the important findings in ovarian cancer DC clinical trials, and discusses new directions which may improve the effectiveness of DC immunotherapy. Expert Commentary: Administration of DC vaccines with other forms of immunotherapy may enhance the efficacy of these treatments, ultimately increasing cures for this disease.
authors.affiliation: a Department of Medicine, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Oncology Institute , Loyola University Chicago , Maywood , IL , USA.
authors.forename: Maureen L
authors.initials: ML
authors.lastname: Drakes
authors.affiliation: a Department of Medicine, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Oncology Institute , Loyola University Chicago , Maywood , IL , USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Stiff
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D019496:Cancer Vaccines
keywords: Dendritic cells; clinical outcome; immune suppression; immunotherapy; ovarian cancer; suppressor macrophages; tumor antigens