title: Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study.
abstract: OBJECTIVE
  Ruptured anterior communicating artery (ACoA) aneurysms occur more frequently in men. The purpose of the study was to investigate sex difference in aneurysm morphologies and clinical outcomes in patients with ruptured ACoA aneurysms.
  
  
  METHODS
  A tertiary referral hospital.
  
  
  METHODS
  A total of 574 consecutive patients with ACoA aneurysms were admitted to our hospital from December 2007 to February 2015. In all, 474 patients (257 men and 217 women) with ruptured ACoA aneurysms were included in the study.
  
  
  METHODS
  Aneurysm morphologies were measured using computed tomographic angiography and clinical outcomes were measured with Glasgow coma score at discharge.
  
  
  RESULTS
  The aneurysm sizes (p=0.001), aneurysm heights (p=0.011), size ratios (p<0.001), flow angles (p=0.047) and vessel angles (p=0.046) were larger in the male patients than in the females. The female patients more often had larger vessel sizes (p=0.002). Multivariate logistic analysis revealed that significant differences in aneurysm morphologies between men and women were aneurysm size (OR 1.1, 95% CI 1.0 to 1.3; p=0.036), aneurysm height (OR 0.8, 95% CI 0. to 0.9; p=0.006) and size ratio (OR 1.4, 95% CI 0.5 to 1.7; p=0.001). There were no statistically significant differences in the outcomes between men and women (OR 1.0, 95% CI 0.6 to 1.7, p=0.857).
  
  
  CONCLUSIONS
  The men were independently associated with larger aneurysm sizes, greater aneurysm heights and larger size ratios. Sex was not a risk factor for poor outcome in patients with ruptured ACoA aneurysms.
authors.affiliation: Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Boli
authors.initials: B
authors.lastname: Lin
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ruan
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
authors.affiliation: Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China Department of Neurosurgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Qichuan
authors.initials: Q
authors.lastname: Zhuge
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Liang Hao
authors.initials: LH
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Yunjun
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000368:Aged; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging*; D020771:Anterior Cerebral Artery / Q000503:physiopathology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed
keywords: NEUROSURGERY