title: Quantitative Signature ofCoronary Stealin a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT.
abstract: Coronary steal(CS) is a physiological process that induces absolute decrease in blood flow in collateralized myocardium compared to resting flow during coronary vasodilation due to redistribution of blood away from collateral-dependent myocardium. Although, CS has been well known for decades, there are very few noninvasive perfusion studies in humans that quantitatively predict the existence of CS. In this study, we show that the quantitative measurement of absolute value of regional myocardial blood flow (MBF) and coronary flow reserve (CFR) using dynamic single photon emitted computed tomography (SPECT) can help estimate the presence of CS in myocardium with obstructed coronary artery and collateral circulation.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA (USA).
authors.forename: Uttam
authors.initials: U
authors.lastname: Shrestha
authors.affiliation: Medical Center, University of California, San Francisco, CA (USA).
authors.forename: Elias H
authors.initials: EH
authors.lastname: Botvinick
authors.affiliation: Medical Center, University of California, San Francisco, CA (USA).
authors.forename: Yerem
authors.initials: Y
authors.lastname: Yeghiazarians
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA (USA).
authors.forename: Youngho
authors.initials: Y
authors.lastname: Seo
authors.affiliation: Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA (USA).
authors.forename: Grant T
authors.initials: GT
authors.lastname: Gullberg