title: Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy.
abstract: A 57-year-old white woman developed autoimmune retinopathy (AIR) in both eyes associated with bilateral autoimmune sensorineural hearing loss. Laboratory testing was positive for 68kDa (heat-shock protein) and 136kDa (human interstitial retinoid-binding protein). Extensive cancer screening was negative. Spectral-domain optical coherence tomography enhanced depth imaging demonstrated a markedly thickened choroid in both eyes. En face imaging showed a distinctive pattern of granular hyperreflective foveal dots. The concurrent sensorineural hearing loss was thought to be of autoimmune origin and also responded to immunosuppressive treatment. Eyes with non-paraneoplastic, seropositive AIR may have associated increased choroidal thickness. Audiology testing should be considered.
authors.forename: Breanna A
authors.initials: BA
authors.lastname: Polascik
authors.forename: Dilraj S
authors.initials: DS
authors.lastname: Grewal
authors.forename: Kim
authors.initials: K
authors.lastname: Jiramongkolchai
authors.forename: Sharon
authors.initials: S
authors.lastname: Fekrat
mesh_terms: D001324:Autoantigens / Q000378:metabolism; D001327:Autoimmune Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002829:Choroid / Q000473:pathology*; D005136:Eye Proteins / Q000378:metabolism; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000000981:diagnostic imaging* / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009929:Organ Size; D012164:Retinal Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000378:metabolism; D041623:Tomography, Optical Coherence; D000099214:Retinol-Binding Proteins, Interstitial
chemical_list: D001324:Autoantigens; D015415:Biomarkers; D005136:Eye Proteins; D006360:Heat-Shock Proteins; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial