title: [Ductal carcinoma in situ: the balance between over- and undertreatment].
abstract: Since population-based breast cancer screening was implemented in the Netherlands, the incidence of Ductal Carcinoma In Situ of the breast, regarded as a non-obligate precursor lesion of breast cancer, has strongly increased. However, the incidence of invasive breast cancer has not decreased. This suggests that a percentage of all the DCIS lesions would never have become symptomatic if no screening was performed. This phenomenon is known as 'overdiagnosis'. Nonetheless, almost all DCIS lesions are managed surgically, often followed by radiotherapy in those having breast-conserving treatment, to avoid potential progression to breast cancer. To prevent potential over- or undertreatment, further studies are required to distinguish low from high risk DCIS. Ultimately this could help avoid non-beneficial intensive treatment for women with low risk DCIS.
authors.affiliation: Antoni van Leeuwenhoek - Nederlands Kanker Instituut, Amsterdam.
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Groen
authors.forename: Lotte E
authors.initials: LE
authors.lastname: Elshof
authors.forename: Emiel J Th
authors.initials: EJ
authors.lastname: Rutgers
authors.forename: Hillegonda A O
authors.initials: HA
authors.lastname: Winter-Warnars
authors.forename: Esther H
authors.initials: EH
authors.lastname: Lips
authors.forename: Jelle
authors.initials: J
authors.lastname: Wesseling
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008403:Mass Screening / Q000009:adverse effects; D015412:Mastectomy, Segmental; D009426:Netherlands