title: Salivary parameters and oral health in the Moebius syndrome.
abstract: OBJECTIVE
  To evaluate salivary characteristics, such as flow rate, buffering capacity and amylase activity, and associate these parameters with oral health in individuals with Moebius syndrome (MS) and controls.
  
  
  METHODS
  The researchers assessed caries (ICDAS), periodontal disease (PSR), and plaque (Silness Löe) indexes in both groups. Unstimulated, stimulated, and bilateral parotid saliva were also collected. The salivary flow (milliliters/minute) and α-amylase activity were measured in all samples. The α-amylase activity was determined by maltose production. The buffering capacity was measured in stimulated saliva by titration of 0.01N HCl.
  
  
  RESULTS
  The occurrence of carious lesions, related to cut-off 2, as well as the occurrence of periodontal disease, was significantly higher (p > 0.05) in participants with MS when compared to the control group. Also, MS individuals presented decreased salivary flow, decreased buffering capacity, and amylase activity.
  
  
  CONCLUSIONS
  MS individuals present salivary alterations, which can be related to higher risk for caries.
authors.affiliation: Researcher, Department of Oral Pathology and Special Patients, School of Dentistry, University of São Paulo, São Paulo, Brazil. carol.martinsmussi@gmail.br.
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Martins Mussi
authors.affiliation: Professor, Ceuma University, Maranhão, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Moffa
authors.affiliation: PhD student, Department of Oral Pathology and Special Patients, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Talita
authors.initials: T
authors.lastname: Castro
authors.affiliation: Postdoctoral researcher, Department of Oral Pathology and Special Patients, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Lira Ortega
authors.affiliation: Undergraduate student, Department of Oral Pathology and Special Patients, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Freitas
authors.affiliation: Professor, Department of Pediatric Dentistry, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Braga
authors.affiliation: Professor, Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
authors.forename: Walter L
authors.initials: WL
authors.lastname: Siqueira
authors.affiliation: Professor, Department of Oral Pathology and Special Patients, School of Dentistry, University of São aulo, São Paulo, Brazil.
authors.forename: Marina Helena
authors.initials: MH
authors.lastname: Cury Gallottini
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D020331:Mobius Syndrome / Q000150:complications*; D009909:Oral Health; D012463:Saliva / Q000737:chemistry*; D012472:Salivation / Q000502:physiology*; D000516:alpha-Amylases / Q000032:analysis
chemical_list: D000516:alpha-Amylases
keywords: Mobius syndrome; facial paralysis; saliva