title: Mechanochemical solid-state synthesis of 2-aminothiazoles, quinoxalines and benzoylbenzofurans from ketones by one-pot sequential acid- and base-mediated reactions.
abstract: α-Chloroketones - obtained by the atom-economical chlorination of ketones with trichloroisocyanuric acid (TCCA) in the presence of p-TSA under ball-milling conditions - were set up for a sequential base-mediated condensation reaction with thiourea/thiosemicarbazides, o-phenylenediamine and salicylaldehyde to afford 2-aminothiazoles, 2-hydrazinylthiazoles, quinoxalines and benzoylbenzofurans, respectively, in respectable yields. The viability of one-pot sequential acid- and base-mediated reactions in the solid state under ball-milling conditions is thus demonstrated.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. nagarajh6@gmail.com moorthy@iitk.ac.in.
authors.forename: Honnappa
authors.initials: H
authors.lastname: Nagarajaiah
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. nagarajh6@gmail.com moorthy@iitk.ac.in.
authors.forename: Abhaya Kumar
authors.initials: AK
authors.lastname: Mishra
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. nagarajh6@gmail.com moorthy@iitk.ac.in.
authors.forename: Jarugu Narasimha
authors.initials: JN
authors.lastname: Moorthy