title: Biomarkers for detection of alcohol consumption in liver transplantation.
abstract: Alcoholic liver disease is an established, yet controversial, indication for liver transplantation. Although an abstinence period of up to 6 mo prior to transplantation is mandatory, alcohol relapse after transplantation is a common event. In case of recurrence of heavy drinking, graft survival is significantly impaired. Guidelines on detection and surveillance of alcohol consumption in this patient cohort are lacking. This review summarizes the challenge of patient selection as well as the current knowledge on established and novel alcohol biomarkers with special focus on liver transplant candidates and recipients.
authors.affiliation: Katharina Staufer, Division of Transplantation, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Katharina
authors.initials: K
authors.lastname: Staufer
authors.affiliation: Katharina Staufer, Division of Transplantation, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Michel
authors.initials: M
authors.lastname: Yegles
mesh_terms: D064829:Alcohol Abstinence; D000428:Alcohol Drinking / Q000009:adverse effects / Q000378:metabolism* / Q000517:prevention & control*; D015415:Biomarkers / Q000378:metabolism; D006085:Graft Survival; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects; D011183:Postoperative Complications / Q000517:prevention & control; D011237:Predictive Value of Tests; D012008:Recurrence; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Ethyl glucuronide; Liver cirrhosis; Long-term alcohol markers; Psychological support; Short-term alcohol markers