title: Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic.
abstract: We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached in the context of its topobiology, and we provide a model that incorporates in vitro and in vivo models as well as in situ findings from intact human marrow to explain the changes seen in myelodysplastic syndrome patients. We highlight the clinical application of the study of the bone marrow microenvironment and its topobiology in myelodysplastic syndromes.
authors.affiliation: Oncology Research Unit, Oncology Hospital, National Medical Center, IMSS, Avenida Cuauhtémoc 330, Colonia Doctores, c.p. 06720 Mexico City, Mexico. eflores.figueroa@gmail.com.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Flores-Figueroa
authors.affiliation: Department of Pathology, Stanford University School of Medicine 300 Pasteur Dr., L235, Stanford, CA 94305, USA. ditag@stanford.edu.
authors.forename: Dita
authors.initials: D
authors.lastname: Gratzinger
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D008264:Macrophages / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000473:pathology; D051379:Mice; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D055153:Stem Cell Niche
keywords: macrophages; mesenchymal stem cells; myelodysplasia; myelodysplastic syndromes; niche; topobiology