title: Condensin-mediated chromosome organization in fission yeast.
abstract: Genome/chromosome structures are formed by a hierarchy of organizing processes ranging from gene interactions to chromosome territory formation. The SMC complex, cohesin, mediates interactions among enhancers and promoters, thereby regulating transcription. Another SMC complex, condensin, also plays critical roles in genome organization, although the detailed mechanisms remain much less well understood. Here, we discuss our recent findings on how fission yeast condensin mediates interactions among genes and how condensin-dependent interactions play dual roles in the chromosome territory arrangement during interphase and in mitotic chromosome organization, which supports the fidelity of chromosome segregation. Our studies suggest that condensin serves as a functional ligature connecting gene interactions, chromosome territory arrangement, transcriptional regulation, and chromosome segregation.
authors.affiliation: Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
authors.forename: Osamu
authors.initials: O
authors.lastname: Iwasaki
authors.affiliation: Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA. noma@wistar.org.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Noma
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D020090:Chromosome Segregation; D015825:Chromosomes, Fungal / Q000235:genetics* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D008938:Mitosis; D046912:Multiprotein Complexes / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism*; D035181:TATA-Box Binding Protein / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D035181:TATA-Box Binding Protein; C108312:condensin complexes; D000251:Adenosine Triphosphatases
keywords: 3D genome organization; Chromosome segregation; Chromosome territory; Condensin; Fission yeast; Mitotic chromosome assembly