title: High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial.
abstract: Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple testing, those biomarkers did not predict severe pulmonary hypertension, death, need of extracorporeal membrane oxygenation, or bronchopulmonary dysplasia.
  
  
  BACKGROUND
  Netherlands Trial Registry: 1310.
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Kitty G
authors.initials: KG
authors.lastname: Snoek
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Ulrike S
authors.initials: US
authors.lastname: Kraemer
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Chantal A
authors.initials: CA
authors.lastname: Ten Kate
authors.affiliation: Division of Asthma, Allergy and Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, Denmark Hill, London, United Kingdom.
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
authors.affiliation: Division of Neonatology, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
authors.forename: Arno
authors.initials: A
authors.lastname: van Heijst
authors.affiliation: Department of Medical and Surgical Neonatology, Bambino Gesu Children's Hospital, Rome, Italy.
authors.forename: Irma
authors.initials: I
authors.lastname: Capolupo
authors.affiliation: Department of Pediatrics, Universitätsmedizin Mannheim, Mannheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schaible
authors.affiliation: Department of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: van Rosmalen
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: René M
authors.initials: RM
authors.lastname: Wijnen
authors.affiliation: Department of Neonatology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Irwin K M
authors.initials: IK
authors.lastname: Reiss
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Dick
authors.initials: D
authors.lastname: Tibboel
mesh_terms: D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D015199:Extracorporeal Membrane Oxygenation / Q000706:statistics & numerical data; D005260:Female; D065630:Hernias, Diaphragmatic, Congenital / Q000401:mortality* / Q000601:surgery; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T; D020097:Natriuretic Peptide, Brain
keywords: Biomarkers; pulmonary hypertension