title: [Recurrence of Waldenström macroglobulinemia accompanied by factor X deficiency].
abstract: A medical check-up revealed severe anemia in an 85-year-old man who had been diagnosed with Waldenström macroglobulinemia 11 years previously. On the other hand, prolonged PT and aPTT were demonstrated on admission, and were attributed to a significant decrease in factor X activity. These abnormalities were all considered to be have been caused by an exacerbation of the underlying disease and, thus, chemotherapy with the RCD regimen (rituximab, cyclophosphamide, dexamethasone) was started. No significant improvement was obtained and the patient died suddenly on day 154. AL amyloidosis was diagnosed by histopathological examinations and also confirmed by a sequence analysis of amyloid protein. This case with Waldenström macroglobulinemia complicated by AL amyloidosis and recurrent factor X deficiency is quite rare.
authors.affiliation: Department of Hematology, Eiju General Hospital.
authors.forename: Shin
authors.initials: S
authors.lastname: Ohara
authors.forename: Masao
authors.initials: M
authors.lastname: Hagihara
authors.forename: Jian
authors.initials: J
authors.lastname: Hua
authors.forename: Morihiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Uchida
authors.forename: Tsuneaki
authors.initials: T
authors.lastname: Yoshinaga
authors.forename: Masahide
authors.initials: M
authors.lastname: Yazaki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sekijima
authors.forename: Fuyuki
authors.initials: F
authors.lastname: Kametani
mesh_terms: D000369:Aged, 80 and over; D001344:Autopsy; D001853:Bone Marrow / Q000473:pathology; D005171:Factor X Deficiency / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012008:Recurrence; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology