title: The common marmoset as an indispensable animal model for immunotherapy development in multiple sclerosis.
abstract: New drugs often fail in the translation from the rodent experimental autoimmune encephalomyelitis (EAE) model to human multiple sclerosis (MS). Here, we present the marmoset EAE model as an indispensable model for translational research into MS. The genetic heterogeneity of this species and lifelong exposure to chronic latent infections and environmental pathogens create a human-like immune system. Unique to this model is the presence of the pathological hallmark of progressive MS, in particular cortical grey matter lesions. Another great possibility of this model is systemic and longitudinal immune profiling, whereas in humans and mice immune profiling is usually performed in a single compartment (i.e. blood or spleen, respectively). Overall, the marmoset model provides unique opportunities for systemic drug-effect profiling.
authors.affiliation: Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. Electronic address: kap@bprc.nl.
authors.forename: Yolanda S
authors.initials: YS
authors.lastname: Kap
authors.affiliation: Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
authors.forename: S Anwar
authors.initials: SA
authors.lastname: Jagessar
authors.affiliation: Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands; Department of Medical Physiology, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Jordon
authors.initials: J
authors.lastname: Dunham
authors.affiliation: Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands; Department of Medical Physiology, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Bert A
authors.initials: BA
authors.lastname: 't Hart
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology; D002144:Callithrix; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D066128:Gray Matter / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D009103:Multiple Sclerosis / Q000628:therapy*; D013154:Spleen / Q000276:immunology