title: An Iridium-Catalyzed Reductive Approach to Nitrones from N-Hydroxyamides.
abstract: An Ir-catalyzed reductive formation of functionalized nitrones from N-hydroxyamides was reported. The reaction took place through two types of iridium-catalyzed reactions including dehydrosilylation and hydrosilylation. The method showed high chemoselectivity in the presence of sensitive functional groups, such as methyl esters, and was successfully applied to the synthesis of cyclic and macrocyclic nitrones, which are known to be challenging compounds to access by conventional methods. (1)H NMR studies strongly supported generation of an N-siloxyamide and an N,O-acetal as the actual intermediates.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Seiya
authors.initials: S
authors.lastname: Katahara
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Kanami
authors.initials: K
authors.lastname: Fujita
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Chida