title: Prediction of Infarct Transmurality From C-Reactive Protein Level and Mean Platelet Volume in Patients With ST-Elevation Myocardial Infarction: Comparison of the Predictive Values of Cardiac Enzymes.
abstract: BACKGROUND
  High C-reactive protein (CRP) and mean platelet volume (MPV) levels are associated with poor prognosis in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to evaluate the relationship between CRP level or MPV and infarct transmurality in patients with STEMI.
  
  
  METHODS
  We retrospectively reviewed CRP level, MPV, and infarct transmurality in 112 STEMI patients who were assessed with contrast-enhanced cardiac magnetic resonance imaging.
  
  
  RESULTS
  When the cut-off peak CRP level and MPV were set at 2.35 mg/dl and 7.3 fl using receiver operating characteristic curves analysis, the sensitivity was 67.3/69.2% and specificity was 76.7/76.7% for differentiating between the groups with and those without transmural involvement. Peak CRP level, MPV, peak creatine kinase-MB (CK-MB) level, and peak high-sensitivity cardiac troponin T (hs-cTnT) level had comparable predictive values for transmural involvement (area under the curve, 0.749, 0.761, 0.680, and 0.696, respectively). High peak CRP level and MPV were independent predictors of transmural involvement after adjusting for the peak CK-MB level, peak hs-cTnT level, baseline thrombolysis in myocardial infarction flow grade, and left ventricular ejection fraction (odds ratio: 5.16/5.42, 95% confidence interval: 1.84-14.50/2.03-14.47, P = 0.002/0.001, respectively) in the logistic regression analysis.
  
  
  CONCLUSIONS
  The results of this study show that peak CRP level and MPV are predictive markers for transmural involvement. Their predictive power for transmural involvement is independent of and comparable to that of peak CK-MB and hs-cTnT levels.
authors.affiliation: Department of Radiology, Chosun University School of Medicine, Gwangju, Republic of Korea.
authors.forename: DongHun
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Republic of Korea. dhchoi@chosun.ac.kr.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Republic of Korea.
authors.forename: Bo-Bae
authors.initials: BB
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Republic of Korea.
authors.forename: Seo-Won
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Republic of Korea.
authors.forename: Keun Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, Republic of Korea.
authors.forename: Heesang
authors.initials: H
authors.lastname: Song
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D003287:Contrast Media; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D062645:Percutaneous Coronary Intervention / Q000379:methods; D011237:Predictive Value of Tests; D012372:ROC Curve; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000601:surgery; D018709:Statistics, Nonparametric; D020107:Troponin T
chemical_list: D003287:Contrast Media; D020107:Troponin T; D002097:C-Reactive Protein; D003402:Creatine Kinase
keywords: C-reactive protein; magnetic resonance imaging; mean platelet volume; myocardial infarction