title: Multitarget Drug Discovery and Polypharmacology.
abstract: Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this ChemMedChem Special Issue on Polypharmacology and Multitarget Drugs. They highlight cases in which a departure from the "one target, one drug" paradigm has proven advantageous, with single molecules that can engage two or more targets to address a given pathology. Articles in this issue underscore the importance of focusing ever more attention to polypharmacology in drug discovery efforts.
authors.affiliation: Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum - Università di Bologna, via Belmeloro 6, Bologna, 40126, Italy. marialaura.bolognesi@unibo.it.
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Bolognesi
authors.affiliation: Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum - Università di Bologna, via Belmeloro 6, Bologna, 40126, Italy. andrea.cavalli@unibo.it.|CompuNet, Istituto Italiano di Tecnologia, via Morego 30, Genova, 16163, Italy. andrea.cavalli@unibo.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cavalli
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D003141:Communicable Diseases / Q000628:therapy; D057890:Epigenomics; D006801:Humans; D064798:Polypharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents