title: DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis.
abstract: DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent nontumorous tissues. In a cohort of 520 patients, DHX33 expression in HCC was closely associated with tumor size (P = 0.007), serum AFP level (P = 0.011), and tumor capsule (P = 0.030). Kaplan-Meier analysis indicated high DHX33 expression was correlated with worse overall and disease-free survival, and higher recurrence rate. The prognostic value of DHX33 was further confirmed by stratified survival analysis. Multivariate analysis revealed DHX33 as an independent prognostic factor for poor overall survival (Hazard Ratio = 1.772, 95% confident interval: 1.451-2.165, P < 0.0001). Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease.
authors.affiliation: Department of Oncology, First Affiliated Hospital of NanChang University, NanChang, Jiangxi 330006, China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Tian
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Zhang
authors.affiliation: Department of Imaging and Interventional Radiology, First Affiliated Hospital of NanChang University, NanChang, Jiangxi 330006, China.
authors.forename: Rong-Guang
authors.initials: RG
authors.lastname: Luo
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of General Surgery, First Affiliated Hospital of NanChang University, NanChang, Jiangxi 330006, China.
authors.forename: Cong
authors.initials: C
authors.lastname: He
authors.affiliation: Department of General Surgery, First Affiliated Hospital of NanChang University, NanChang, Jiangxi 330006, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
authors.affiliation: Department of General Surgery, First Affiliated Hospital of NanChang University, NanChang, Jiangxi 330006, China. Electronic address: eganzhou@163.com.
authors.forename: Jing-Sheng
authors.initials: JS
authors.lastname: Zeng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D002681:China / Q000453:epidemiology; D053487:DEAD-box RNA Helicases / Q000235:genetics* / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015996:Survival Rate; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C568925:DHX33 protein, human; D053487:DEAD-box RNA Helicases
keywords: DHX33; Hepatocellular carcinoma; Immunohistochemistry; Prognosis