title: An overview of innovations and industrial solutions in Protein Microarray Technology.
abstract: The complexity involving protein array technology reflects in the fact that instrumentation and data analysis are subject to change depending on the biological question, technical compatibility of instruments and software used in each experiment. Industry has played a pivotal role in establishing standards for future deliberations in sustenance of these technologies in the form of protein array chips, arrayers, scanning devices, and data analysis software. This has enhanced the outreach of protein microarray technology to researchers across the globe. These have encouraged a surge in the adaptation of "nonclassical" approaches such as DNA-based protein arrays, micro-contact printing, label-free protein detection, and algorithms for data analysis. This review provides a unique overview of these industrial solutions available for protein microarray based studies. It aims at assessing the developments in various commercial platforms, thus providing a holistic overview of various modalities, options, and compatibility; summarizing the journey of this powerful high-throughput technology.
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India.
authors.forename: Shabarni
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India.
authors.forename: K P
authors.initials: KP
authors.lastname: Manubhai
authors.affiliation: School of Engineering, University of Warwick, Coventry, UK.
authors.forename: Vishwesh
authors.initials: V
authors.lastname: Kulkarni
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India.
authors.forename: Sanjeeva
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D004059:Diffusion of Innovation; D023281:Genomics / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007221:Industry / Q000379:methods*; D062069:Inventions; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods*; D011485:Protein Binding; D040901:Proteomics / Q000295:instrumentation / Q000379:methods; D015203:Reproducibility of Results; D012984:Software
keywords: Arrayers; Data analysis software; Industry; Protein microarrays; Scanners