title: Ventral Striatum Connectivity During Reward Anticipation in Adolescent Smokers.
abstract: Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.
authors.affiliation: a Department of Psychology , University College Dublin , Dublin , Ireland.
authors.forename: Lee
authors.initials: L
authors.lastname: Jollans
authors.affiliation: a Department of Psychology , University College Dublin , Dublin , Ireland.
authors.forename: Cao
authors.initials: C
authors.lastname: Zhipeng
authors.affiliation: b Bioimaging, School of Medicine , Boston University , Boston , Massachusetts.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Icke
authors.affiliation: a Department of Psychology , University College Dublin , Dublin , Ireland.
authors.forename: Ciara
authors.initials: C
authors.lastname: Greene
authors.affiliation: c Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences , Trinity College Dublin , Dublin , Ireland.
authors.forename: Clare
authors.initials: C
authors.lastname: Kelly
authors.affiliation: d Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University , Mannheim , Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.affiliation: c Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences , Trinity College Dublin , Dublin , Ireland.
authors.forename: Arun L W
authors.initials: AL
authors.lastname: Bokde
authors.affiliation: e University Medical Centre Hamburg-Eppendorf , Hamburg , Germany.
authors.forename: Uli
authors.initials: U
authors.lastname: Bromberg
authors.affiliation: e University Medical Centre Hamburg-Eppendorf , Hamburg , Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Büchel
authors.affiliation: h Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience , King's College London , London , United Kingdom.
authors.forename: Anna
authors.initials: A
authors.lastname: Cattrell
authors.affiliation: f Department of Psychiatry , Universite de Montreal, CHU Ste Justine Hospital , Montreal , Canada.|g Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience , King's College London , London , United Kingdom.
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Conrod
authors.affiliation: u Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience , King's College London , London , United Kingdom.
authors.forename: Sylvane
authors.initials: S
authors.lastname: Desrivières
authors.affiliation: i Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University , Mannheim , Germany.
authors.forename: Herta
authors.initials: H
authors.lastname: Flor
authors.affiliation: j Neurospin, Commissariat à l'Energie Atomique , CEA-Saclay Center , Paris , France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Frouin
authors.affiliation: k Department of Psychiatry and Psychotherapy , University Medical Center Hamburg-Eppendorf (UKE) , Hamburg , Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Gallinat
authors.affiliation: l Departments of Psychiatry and Psychology , University of Vermont , Burlington , Vermont.
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
authors.affiliation: m Sir Peter Mansfield Imaging Centre School of Physics and Astronomy , University of Nottingham , University Park , Nottingham , United Kingdom.
authors.forename: Penny
authors.initials: P
authors.lastname: Gowland
authors.affiliation: n Department of Psychiatry and Psychotherapy, Campus Charité Mitte , Charité, Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.affiliation: o Physikalisch-Technische Bundesanstalt (PTB) , Braunschweig and Berlin , Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Ittermann
authors.affiliation: p Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn , Paris , France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Martinot
authors.affiliation: q Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Psychiatry Department 91G16, Orsay Hospital , Paris , France.
authors.forename: Eric
authors.initials: E
authors.lastname: Artiges
authors.affiliation: d Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University , Mannheim , Germany.|i Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University , Mannheim , Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Nees
authors.affiliation: j Neurospin, Commissariat à l'Energie Atomique , CEA-Saclay Center , Paris , France.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Papadopoulos Orfanos
authors.affiliation: r Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry , University of Toronto , Toronto , Canada.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Paus
authors.affiliation: s Department of Psychiatry and Neuroimaging Center , Technische Universität Dresden , Dresden , Germany.
authors.forename: Michael N
authors.initials: MN
authors.lastname: Smolka
authors.affiliation: n Department of Psychiatry and Psychotherapy, Campus Charité Mitte , Charité, Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Walter
authors.affiliation: t Department of Psychiatry , Universite de Montreal, CHU Ste Justine Hospital , Montreal , Canada.
authors.forename: Gunter
authors.initials: G
authors.lastname: Schumann
authors.affiliation: a Department of Psychology , University College Dublin , Dublin , Ireland.
authors.forename: Robert
authors.initials: R
authors.lastname: Whelan
mesh_terms: D000293:Adolescent; D059031:Anticipation, Psychological / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D000069550:Machine Learning; D008279:Magnetic Resonance Imaging; D008297:Male; D009042:Motivation / Q000502:physiology*; D009415:Nerve Net / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012201:Reward; D040242:Risk Reduction Behavior; D012907:Smoking / Q000503:physiopathology* / Q000523:psychology*; D066328:Ventral Striatum / Q000503:physiopathology*