The new steroidal glycosides from the aerial parts of Lepidogrammitis drymoglossoides.
Two new steroidal glycosides ponasteroside C (1) and ponasteroside D (2) were isolated from the aerial parts of Lepidogrammitis drymoglossoides. Their structures were elucidated by various spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cell lines, and compounds 1 and 2 showed mild activity against all the test cell lines.
a Key Laboratory of Plant Resource Conservation and Utilization (Jishou University) , College of Hunan Province , Jishou 416000 , China.
Hua
H
Wei
b Institute of Medicinal Plant Development , Beijing 100193 , China.|c Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin 150040 , China.
Hai
H
Jiang
a Key Laboratory of Plant Resource Conservation and Utilization (Jishou University) , College of Hunan Province , Jishou 416000 , China.
Zhu-Xiang
ZX
Liu
a Key Laboratory of Plant Resource Conservation and Utilization (Jishou University) , College of Hunan Province , Jishou 416000 , China.
Gui
G
Li
a Key Laboratory of Plant Resource Conservation and Utilization (Jishou University) , College of Hunan Province , Jishou 416000 , China.
Hua
H
Long
a Key Laboratory of Plant Resource Conservation and Utilization (Jishou University) , College of Hunan Province , Jishou 416000 , China.
Jian-Wu
JW
He
a Key Laboratory of Plant Resource Conservation and Utilization (Jishou University) , College of Hunan Province , Jishou 416000 , China.
Gong-Xi
GX
Chen
b Institute of Medicinal Plant Development , Beijing 100193 , China.
Jun-Shan
JS
Yang
b Institute of Medicinal Plant Development , Beijing 100193 , China.
Guo-Xu
GX
Ma
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010840:Phytosterols; C000613860:ponasteroside C; C000613861:ponasteroside D
Lepidogrammitis drymoglossoides; Polypodiaceae; cytotoic activity; steroidal glycosides