Stroke volume and cardiac output evaluation by electrical cardiometry: accuracy and reference nomograms in hemodynamically stable preterm neonates.
To investigate the accuracy of electrical cardiometry (EC) to measure stroke volume (SV) and cardiac output (CO) and to provide gestational age (GA) and birth weight (BW)-based reference data for SV and CO in hemodynamically stable preterm neonates.



Prospective observational blinded study. Paired measurements of SV and CO on stable preterm infants without any hemodynamic compromise were carried out using EC (SVEC) and echocardiography (SVECHO).



Seventy-nine preterm neonates (mean GA: 31±3.2 weeks) were enrolled. A good correlation was found for SV (r=0.743; P<0.0001) and CO (r=0.7; P<0.0001) measured by EC and echocardiography. These correlations remained significant after adjusting for GA, patent ductus arteriosus and type of respiratory support (SV: St.β=0.48, P<0.0001 and CO: St.β=0.69, P<0.0001). Mean biases (and variabilities) were -1.1 (from 0.7 to -2.9) ml and -0.21 (from 0.15 to -0.55) l min(-1) for SV and CO, respectively. Local regression shows a tendency for EC to overestimate SV and CO especially at higher values (at about >2 ml and >0.4 l min(-1), respectively). Coefficient of variation of SV was 48.9% and 52%, for EC and echocardiography. SV and CO rose with increasing GA and BW following an exponential equation (R(2)>0.8).



Measuring SV and CO with EC in hemodynamically stable preterm infants shows good correlation and variability similar to that of echocardiography. A trend to overestimation exists at highest values, but it is unlikely to be clinically significant. Reference GA and BW-based nomograms for SV and CO are provided.
Cardiac ICU, "Marie Lannelongue" Surgical Center, South Paris University Hospitals, Paris, France.|Division of Paediatrics and Neonatal Critical Care, APHP, South Paris University Hospitals, "A. Beclere" Medical Center, Paris, France.
A
0000-0003-1510-3347
A
Boet
Division of Paediatrics and Neonatal Critical Care, APHP, South Paris University Hospitals, "A. Beclere" Medical Center, Paris, France.
G
G
Jourdain
Cardiac ICU, "Marie Lannelongue" Surgical Center, South Paris University Hospitals, Paris, France.
S
S
Demontoux
Division of Paediatrics and Neonatal Critical Care, APHP, South Paris University Hospitals, "A. Beclere" Medical Center, Paris, France.|Institute of Anaesthesiology and Critical Care, Catholic University of the Sacred Heart, Rome, Italy.
D
D
De Luca
D001724:Birth Weight; D002307:Cardiography, Impedance / Q000379:methods / Q000592:standards*; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D005602:France; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D016014:Linear Models; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D015999:Multivariate Analysis; D049451:Nomograms; D019095:Point-of-Care Systems; D011446:Prospective Studies; D013318:Stroke Volume; D062606:Tertiary Care Centers