Serum levels of glial fibrillary acidic protein and Nogo-A in children with autism spectrum disorders.
BACKGROUND
Improved biomarkers would facilitate the diagnosis and treatment of autism spectrum disorders (ASD).


OBJECTIVE
Our objective was to examine the levels of Nogo-A and glial fibrillary acidic protein (GFAP) in children with ASD.


METHODS
Serum concentrations of GFAP and Nogo-A were determined by enzyme-linked immunosorbent assay.


RESULTS
In this preliminary study, we found that serum Nogo-A was not found significantly different between groups, while serum levels of GFAP were significantly lower in ASD than controls.


CONCLUSIONS
It will be of great interest to determine other potential causes of elevated serum levels of GFAP, and whether this elevation has any phenotypic effect.
a Department of Nutrition and Dietetics , School of Health, Batman University , Batman , Turkey ;
Ihsan
I
Cetin
b Department of Chemistry , Institute of Science, Batman University , Batman , Turkey ;
Ihsan
I
Tezdig
c Clinic of Child and Adolescent Psychiatry , Bakirköy Dr Sadi Konuk Training and Educatin Hospital, Istanbul University , İstanbul , Turkey ;
Mahmut Cem
MC
Tarakcioglu
d Department of Child and Adolescent Psychiatry , Cerrahpaşa School of Medicine, Istanbul University , İstanbul , Turkey ;
Muhammed Tayyib
MT
Kadak
e Department of Psychiatry , Cerrahpaşa School of Medicine, Istanbul University , İstanbul , Turkey ;
Omer Faruk
OF
Demirel
f Department of Biochemistry , BezmiAlem Vakif University , İstanbul , Turkey.
Omer Faruk
OF
Ozer
D000067877:Autism Spectrum Disorder / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D006801:Humans; D000070798:Nogo Proteins / Q000097:blood*
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D000070798:Nogo Proteins
Autism; ELISA; GFAP; Nogo-A