A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers.
Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; β = 0.29; P = 0.002), and an increased inflammatory score (β = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father's occupation and the highest household occupation, revealing a significant difference between "stable Non-manual" profiles over the life course versus "Manual to Non-manual" profiles (β = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course.
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|INSERM, UMR1027, Université Toulouse III-Paul Sabatier, 31000 Toulouse, France.
Raphaële
R
Castagné
INSERM, UMR1027, Université Toulouse III-Paul Sabatier, 31000 Toulouse, France.
Cyrille
C
Delpierre
INSERM, UMR1027, Université Toulouse III-Paul Sabatier, 31000 Toulouse, France.
Michelle
M
Kelly-Irving
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Gianluca
G
Campanella
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Florence
F
Guida
Fondazione IRCCS- Instituto Nazionale dei Tumori, Milan, Italy.
Vittorio
V
Krogh
Istituto per lo Studio e la Prevenzione Oncologica (ISPO Toscana), Florence, Italy.
Domenico
D
Palli
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Salvatore
S
Panico
Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Turin, Italy.
Carlotta
C
Sacerdote
Cancer registry and Histopathology Unit, Azienda Ospedaliera 'Civile -M.P.Arezzo', Ragusa, Italy.
Rosario
R
Tumino
National Hellenic Research Foundation, Institute of Biology, Pharmaceutical Chemistry and Biotechnology, Athens, Greece.
Soterios
S
Kyrtopoulos
Institute for Risk Assessment, Division of Environmental Epidemiology, Utrecht University, Utrecht, the Netherlands.
Fatemeh Saberi
FS
Hosnijeh
INSERM, UMR1027, Université Toulouse III-Paul Sabatier, 31000 Toulouse, France.
Thierry
T
Lang
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Institute for Risk Assessment, Division of Environmental Epidemiology, Utrecht University, Utrecht, the Netherlands.
Roel
R
Vermeulen
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|HuGeF, Human Genetics Foundation, Torino, Italy.|MRC-PHE Centre for Environment and Health, Imperial College, London, London, UK.
Paolo
P
Vineis
Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Silvia
S
Stringhini
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Institute for Risk Assessment, Division of Environmental Epidemiology, Utrecht University, Utrecht, the Netherlands.|MRC-PHE Centre for Environment and Health, Imperial College, London, London, UK.
Marc
M
Chadeau-Hyam
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005060:Europe; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012937:Social Mobility
D015415:Biomarkers; D016179:Granulocyte Colony-Stimulating Factor