Renal cell carcinoma: Are we attacking a different tumor over the past 10 years?
OBJECTIVE
There is a noticeable increase in the presentation of different types of urological malignancies at a younger age of presentation, in our institution. The objective of our study was to investigate cases presented with renal cell carcinoma, managed in the past 10 years for any possible epidemiological and cancer characteristics changes.


METHODS
Retrospective data collection for cases managed by our institution in the time period (2002-2012) was done. We included patients with complete data and pathologically proven renal cell carcinoma at final diagnosis.


RESULTS
Complete data could be retrieved for 334 patients. The mean age of cases was 43.5 years, with 279 (83%), 200 (60%) and 128 (38%) of patients younger than 60, 50 and 40 years respectively. Males and females involvement were 191 (57%) and 143 (43%) respectively. By histopathology, 200 (60%) of patients had clear cell (CC) RCC and 134 (40%) patients had non-clear cell type (papillary or chromophobe). The mean tumor size was 10.9 cm and partial nephrectomy was applied for 16% of all the cases, including 65% for cases with tumor size less than 4 cm.


CONCLUSIONS
There is a marked increase in the prevalence of renal cell carcinoma in the past 10 years, among younger age group, with higher rate for involvement of female gender. RCC is tending to present with large tumor size and more prevalence of non-clear cell histopathology. The use of partial nephrectomy is accepted for patients presented with renal mass and can safely challenge larger sized tumors.
Department of Urology, Alexandria University.
Ahmed Fouad
AF
Kotb
Department of Urology, Alexandria University.
Doaa
D
Attia
Department of Urology, Alexandria University.
Mohamed Mohie
MM
Hashad
Department of Urology, Alexandria University.
Tamer Mohammed Abou
TM
Youssif
Department of Urology, Alexandria University.
Nora
N
Abdelkawy
Department of Urology, Alexandria University.
Asmaa
A
Ismail
Department of Urology, Alexandria University.
Ahmed
A
Elabbady
Department of Urology, Alexandria University.
Mohamed
M
Adel Atta
Radical nephrectomy; Renal cell carcinoma; partial nephrectomy