Analysis of Manganese Superoxide Dismutase and Glutathione Peroxidase 1 Gene Polymorphisms in Vitiligo.
Vitiligo is a hereditary/acquired progressive pigmentation disorder characterized by discoloration of skin as a result of melanocyte dysfunction. Recent studies have proposed that oxidant/antioxidant status plays an important role in vitiligo pathogenesis because of the toxic effects on melanocytes. In this study, we aimed to investigate possible associations of MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms with vitiligo with in Turkish population. The study group consists of 57 patients with vitiligo and 69 healthy controls. Genotyping is performed to identify MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms. The method used for genotyping was based on the PCR amplification and detection of polymorphisms by hybridization probes labeled with fluorescent dyes. Both the genotype and allele frequencies of MnSOD Ala-9Val (p = 0.817 and p = 0.553, respectively) and GPx1 Pro198Leu polymorphisms (p = 0.422 and p = 0.673, respectively) were not significantly different between vitiligo patients and the control group. Although no significant difference was found, this is the first report investigating the possible associations between the MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms in Turkish population. Further studies with large populations will be able to clarify the association better.
Department of Dermatology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey. havvayildiz1982@mynet.com.
Havva Yıldız
HY
Seçkin
Department of Dermatology, School of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
Göknur
G
Kalkan
Department of Biochemistry, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
İlknur
İ
Bütün
Department of Biochemistry, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
Ali
A
Akbaş
Department of Dermatology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
Yalçın
Y
Baş
Department of Medical Biology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
Nevin
N
Karakuş
Department of Biochemistry, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
İsmail
İ
Benli
D000293:Adolescent; D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D014421:Turkey; D014820:Vitiligo / Q000201:enzymology / Q000235:genetics*; D055815:Young Adult; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2; C000722067:GPX1 protein, human
GPx1; MnSOD; Polymorphism; Vitiligo