Therapeutic uses for Angiotensin-(1-7).
BACKGROUND
Angiotensin-(1-7) is a key component of the Renin-Angiotensin System, which can counter-regulate several deleterious effects caused by angiotensin II. Due to the potential for therapeutic use, several of its actions are specifically described in patents.


METHODS
In this review, the authors describe a plethora of therapeutic uses for Angiotensin-(1-7), claimed and supported by experimental evidence in patent documents and applications.


CONCLUSIONS
The clinical potential of Angiotensin-(1-7) as a therapeutic agent to treat several pathologies is evidenced by the variety of patents and clinical trials involving this peptide. Cancer treatment is one of the most advanced therapeutic areas, but clinical studies are also available in several other areas, such as cardiovascular, hematological, transplantation, surgical and medical procedures.
a Fundação Oswaldo Cruz , Centro de Desenvolvimento Tecnológico em Saúde (CDTS) , Rio de Janeiro , Brazil.
Alice
A
Machado-Silva
b Instituto de Ciências Biológicas, Departamento de Fisiologia e Biofísica , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
Danielle
D
Passos-Silva
b Instituto de Ciências Biológicas, Departamento de Fisiologia e Biofísica , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
Robson Augusto
RA
Santos
c Instituto de Ciências Exatas, Departamento de Química , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
Rubén Dario
RD
Sinisterra
D000803:Angiotensin I / Q000378:metabolism / Q000627:therapeutic use*; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D002986:Clinical Trials as Topic; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010330:Patents as Topic; D010446:Peptide Fragments / Q000378:metabolism / Q000627:therapeutic use*; D012084:Renin-Angiotensin System / Q000502:physiology*
D010446:Peptide Fragments; D000804:Angiotensin II; D000803:Angiotensin I; C118790:angiotensin I (1-7)
Angiotensin (1-7); Arg0; Mas receptor; PanCyte; RAS; TXA-127