Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles.
An intramolecular hydroarylation-redox cross-dehydrogenative coupling (CDC) of propargylic anilines with indoles proceeded in the presence of zinc(II) catalysts to give 2-indolyltetrahydroquinolines in good to high yields. Three C-H bonds (two sp(2) and one sp(3) ) are activated in one shot and these hydrogen atoms are trapped by a propargylic triple bond in the molecule.
Chemical Resources Laboratory, Tokyo Institute of Technology, Yokohama, Kanagawa, 226-8503, Japan.
Guangzhe
G
Li
Chemical Resources Laboratory, Tokyo Institute of Technology, Yokohama, Kanagawa, 226-8503, Japan. hiro@res.titech.ac.jp.
Hiroyuki
H
Nakamura
C−H activation; cross-dehydrogenative coupling; intramolecular hydroarylation; tetrahydroquinoline; zinc catalysts