Effects of trace metal ions on secondary metabolism and the morphological development of streptomycetes.
Bacteria belonging to the Streptomyces genus are characterized by a complex life cycle and the production of many bioactive secondary metabolites. Trace metals play an important role in streptomycete metabolism and development, however, their mechanism of action is not fully understood. In this review, we summarize the present knowledge on metallosensing regulators and trace metal action, as well as discuss the possible application in natural product discovery.
Evaluation and Support Organization for Young Researchers, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan.
Fabricio M
FM
Locatelli
Evaluation and Support Organization for Young Researchers, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan.
Kian-Sim
KS
Goo
Oceanography Section, Science Research Center, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan. ulanova@kochi-u.ac.jp.
Dana
D
Ulanova
D008670:Metals / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000254:growth & development; D014131:Trace Elements / Q000494:pharmacology*
D008670:Metals; D014131:Trace Elements