What we learned about the role of antenatal magnesium sulfate for the prevention of cerebral palsy.
Based on the convincing case control study of Nelson and Grether which suggested that the administration of magnesium sulfate to mothers prior to early preterm birth might protect their offspring from cerebral palsy, and a pilot study by John Hauth et al. at the University of Alabama at Birmingham, the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, with co-funding from the National Institute of Neurologic Disorders and Stroke embarked on the Beneficial Effects of Antenatal Magnesium (BEAM) Trial in 1997.
Department of Obstetrics and Gynecology, Warren Alpert Medical School, Brown University, Providence, RI 02905. Electronic address: DRouse@Wihri.org.
Dwight J
DJ
Rouse
Department of Neurological Sciences and Pediatrics, University of Vermont HSRF 426, 149 Beaumont Avenue, Burlington, VT 05405.
Deborah
D
Hirtz
D000328:Adult; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000188:drug therapy / Q000517:prevention & control*; D004311:Double-Blind Method; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010865:Pilot Projects; D011247:Pregnancy; D047928:Premature Birth / Q000503:physiopathology; D011295:Prenatal Care / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D018696:Neuroprotective Agents; D008278:Magnesium Sulfate
Cerebral palsy; Magnesium sulfate