Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 3: Articular Cartilage.
Focal chondral defects of the articular surface are a common occurrence in the field of orthopaedics. These isolated cartilage injuries, if not repaired surgically with restoration of articular congruency, may have a high rate of progression to posttraumatic osteoarthritis, resulting in significant morbidity and loss of function in the young, active patient. Both isolated and global joint disease are a difficult entity to treat in the clinical setting given the high amount of stress on weightbearing joints and the limited healing potential of native articular cartilage. Recently, clinical interest has focused on the use of biologically active compounds and surgical techniques to regenerate native cartilage to the articular surface, with the goal of restoring normal joint health and overall function. This article presents a review of the current biologic therapies, as discussed at the 2015 American Orthopaedic Society for Sports Medicine (AOSSM) Biologics Think Tank, that are used in the treatment of focal cartilage deficiencies. For each of these emerging therapies, the theories for application, the present clinical evidence, and specific areas for future research are explored, with focus on the barriers currently faced by clinicians in advancing the success of these therapies in the clinical setting.
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Jason P
JP
Zlotnicki
Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.
Andrew G
AG
Geeslin
The University of Edinburgh, Edinburgh, UK.
Iain R
IR
Murray
University of California, Los Angeles, California, USA.
Frank A
FA
Petrigliano
Steadman Philippon Research Institute, Vail, Colorado, USA.
Robert F
RF
LaPrade
Author deceased.; American Orthopaedic Society for Sports Medicine, Rosemont, Illinois, USA.
Barton J
BJ
Mann
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Volker
V
Musahl
chondral defects; growth factors; mesenchymal stem cells; platelet-rich plasma; scaffolds