A comparative study of strontium-substituted hydroxyapatite coating on implant's osseointegration for osteopenic rats.
Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for the implants in cementless arthroplasty. However, its effect is not sufficient for osteoporotic bone. Strontium (Sr) promotes osteoblast proliferation and inhibits osteoclast proliferation and positively affects bone regeneration. The aim of this study was to confirm the effects of strontium-substituted hydroxyapatite (Sr-HA) coating via electrochemical deposition on implant's osseointegration in the osteoporotic condition. Female Sprague Dawley rats were used for this study. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into four groups: group HA; group 5 % Sr-HA; group 10 % Sr-HA; and group 20 % Sr-HA. Afterward, all rats from groups HA, 5 % Sr-HA, 10 % Sr-HA, and 20 % Sr-HA received implants with hydroxyapatite coating containing 0, 5, 10, and 20 % Sr. Implants were inserted bilaterally in all animals until death at 12 weeks. The bilateral femurs of rats were harvested for evaluation. All treatment groups increased new bone formation around the surface of titanium rods and push-out force; group 20 % Sr-HA showed the strongest effects on new bone formation and biomechanical strength. Additionally, these are significant differences in bone formation and push-out force was observed between groups 5 % Sr-HA and 10 % Sr-HA. This finding suggests that Sr-HA coating can improve implant osseointegration, and the 20 % Sr coating exhibited the best properties for implant osseointegration among the tested coatings in osteoporosis rats.
Department of Orthopaedic Surgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe shan Xi Road, Wuhu, 241001, Anhui, People's Republic of China.|Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Zhou-Shan
ZS
Tao
Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Bing-Li
BL
Bai
Department of Orthopaedic Surgery, Hangzhou Bay Hospital of Ningbo, Hangzhou, 315000, People's Republic of China.
Xing-Wen
XW
He
Department of Orthopaedic Surgery, Jingmen NO.1 People's Hospital, Jingmen, 44800, Hubei, People's Republic of China.
Wei
W
Liu
Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Hang
H
Li
Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Qiang
Q
Zhou
Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Tao
T
Sun
Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Zheng-Liang
ZL
Huang
Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Kai-Kai
KK
Tu
Department of Orthopaedic Surgery, Wenzhou Central Hospital, Wenzhou, 325000, Zhejiang, People's Republic of China.
Yang-Xun
YX
Lv
Sichuan Provincial Orthopedics Hospital, NO.132 West First Section First Ring Road, Chengdu, 610000, Sichuan, People's Republic of China.
Wei
W
Cui
Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China. tzs19900327@163.com.
Lei
L
Yang
D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D005260:Female; D005269:Femur / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D006882:Hydroxyapatites / Q000494:pharmacology*; D020007:Implants, Experimental; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects*; D017207:Rats, Sprague-Dawley; D013324:Strontium / Q000494:pharmacology*; D055114:X-Ray Microtomography
D020099:Coated Materials, Biocompatible; D006882:Hydroxyapatites; C076185:strontium hydroxyapatite; D013324:Strontium
Osseointegration; Osteoporosis; Strontium; Titanium implants