Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones.
The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.
Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang 790-784, Korea. pjw@postech.ac.kr.
Yongjin
Y
Kim
Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang 790-784, Korea. pjw@postech.ac.kr.
Han Kyu
HK
Pak
Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang 790-784, Korea. pjw@postech.ac.kr.
Young Ho
YH
Rhee
Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang 790-784, Korea. pjw@postech.ac.kr.
Jaiwook
J
Park