Guillain-Barré syndrome and cytomegalovirus infection during pregnancy.
Guillain-Barré syndrome (GBS) is an immune-mediated disorder which can be triggered by cytomegalovirus (CMV) infection. GBS following CMV primary infection is a rare event during pregnancy, which raises the question of maternal and fetal management. We describe an unusual case of GBS after CMV primary infection in a pregnant woman. The mother was successfully treated with standard immunoglobulins but in utero fetal death caused by CMV congenital infection unfortunately occurred. Similar cases have rarely been reported in the literature.
Institut de Biologie Structurale (IBS), CEA, CNRS, University Grenoble Alpes, 38044 Grenoble, France; Laboratory of Virology, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France. Electronic address: jlupo@chu-grenoble.fr.
Julien
J
Lupo
Institut de Biologie Structurale (IBS), CEA, CNRS, University Grenoble Alpes, 38044 Grenoble, France; Laboratory of Virology, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Raphaële
R
Germi
Genetic and Procreation Department, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Dominique
D
Jean
Laboratory of Virology, Grenoble University Hospital, 38043 Grenoble, France.
Monique
M
Baccard-Longère
General Neurology Unit, Psychiatry and Neurology Department, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Olivier
O
Casez
General Neurology Unit, Psychiatry and Neurology Department, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Gérard
G
Besson
Medical Intensive Care Unit, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Alain
A
Rougé
Pathology Department, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Jean
J
Boutonnat
Medical Intensive Care Unit, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Carole
C
Schwebel
Gynaecology, Obstetric and Reproductive Medicine Department, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Pascale
P
Hoffmann
Institut de Biologie Structurale (IBS), CEA, CNRS, University Grenoble Alpes, 38044 Grenoble, France; Laboratory of Virology, Grenoble University Hospital, 38043 Grenoble, France; University Grenoble Alpes, 38042 Grenoble, France.
Patrice
P
Morand
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D005313:Fetal Death; D020275:Guillain-Barre Syndrome / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology*; D016896:Treatment Outcome
D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous
Congenital infection; Cytomegalovirus; Guillain-Barré syndrome; Immunoglobulins; Pregnancy