Diamond Quantum Devices in Biology.
The currently available techniques for molecular imaging capable of reaching atomic resolution are limited to low temperatures, vacuum conditions, or large amounts of sample. Quantum sensors based on the spin-dependent photoluminescence of nitrogen-vacancy (NV) centers in diamond offer great potential to achieve single-molecule detection with atomic resolution under ambient conditions. Diamond nanoparticles could also be prepared with implanted NV centers, thereby generating unique nanosensors that are able to traffic into living biological systems. Therefore, this technique might provide unprecedented access and insight into the structure and function of individual biomolecules under physiological conditions as well as observation of biological processes down to the quantum level with atomic resolution. The theory of diamond quantum sensors and the current developments from their preparation to sensing techniques have been critically discussed in this Minireview.
Institut für Organische Chemie III, Universität Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Deutschland. Yuzhou.Wu@uni-ulm.de.
Yuzhou
Y
Wu
Institut für Quantenoptik, Universität Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Deutschland. fedor.jelezko@uni-ulm.de.
Fedor
F
Jelezko
Institut für Theoretische Physik, Albert-Einstein-Allee 11, 89069, Ulm, Deutschland. martin.plenio@uni-ulm.de.
Martin B
MB
Plenio
Institut für Organische Chemie III, Universität Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Deutschland. Tanja.Weil@uni-ulm.de.
Tanja
T
Weil
D004337:Drug Carriers / Q000737:chemistry; D005293:Ferritins / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D058612:Nanodiamonds / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D011789:Quantum Theory
D004337:Drug Carriers; D058612:Nanodiamonds; D005293:Ferritins; D009584:Nitrogen
NV diamond; drug delivery; hyperpolarization; quantum sensors; single-molecule magnetic resonance