Interleukin-12 serum level has prognostic value in patients with ST-segment elevation myocardial infarction.
The study aimed to evaluate whether serum inflammatory markers have prognostic value in patients with ST-segment elevation myocardial infarction (STEMI).



The role of cytokine-driven inflammation in the development of postdischarge complications after STEMI is obscured.



We recruited 214 patients who were admitted within 24 h of STEMI onset to our Institute. IL-1α, -6, -8, -10, -12, TNF-α, and CRP serum levels were measured on the 10-14th day after STEMI onset.



Serum levels of IL-12, TNF-α, and CRP were significantly higher in patients with 3 affected coronary arteries compared to those with 1 affected coronary artery. However, only Killip class II-IV at admission and IL-12 serum level ≥90.0 pg/mL were defined as statistically significant predictors of adverse outcome after 1 year of follow-up.



IL-12 serum level may be suggested as a candidate prognostic marker if measured 10-14 days after STEMI onset.
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation.
Mikhail V
MV
Zykov
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation; Kemerovo State Medical Academy, Voroshilova Street 22A, Kemerovo 650029, Russian Federation.
Olga L
OL
Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation; Kemerovo State Medical Academy, Voroshilova Street 22A, Kemerovo 650029, Russian Federation.
Vasiliy V
VV
Kashtalap
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation. Electronic address: antonkutikhin@gmail.com.
Anton G
AG
Kutikhin
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation.
Leonid S
LS
Barbarash
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018664:Interleukin-12 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000072657:ST Elevation Myocardial Infarction / Q000097:blood*; D013997:Time Factors
D015415:Biomarkers; D018664:Interleukin-12
Atherosclerosis; Inflammation; Interleukin-12; Prognosis; ST-segment elevation myocardial infarction