Resolution of Graves' disease after renal transplantation.
We report a case of an adolescent boy with Down's syndrome and ESRD on hemodialysis who developed mild Graves' disease that was not amenable to radioablation, surgery, or ATDs. After 14 months of observation without resolution of Graves' disease, he successfully received a DDRT with a steroid minimization protocol. Thymoglobulin and a three-day course of steroids were used for induction and he was started on tacrolimus, MMF, and pravastatin for maintenance transplant immunosuppression. One month after transplantation, all biochemical markers and antibody profiling for Graves' disease had resolved and remain normal one yr later.
Kaiser Permanente, Oakland, CA, USA.
Yvonne
Y
Lee
Section of Nephrology, Department of Pediatrics, University of California, Davis, Sacramento, CA, USA.
Lavjay
L
Butani
Section of Endocrinology, Department of Pediatrics, University of California, Davis, Sacramento, CA, USA.
Nicole
N
Glaser
Section of Nephrology, Department of Pediatrics, University of California, Davis, Sacramento, CA, USA.
Stephanie
S
Nguyen
D000293:Adolescent; D006111:Graves Disease / Q000150:complications / Q000601:surgery*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male
Down's syndrome; Graves’ disease; adolescent; hemodialysis; renal transplantation