Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events.
Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions between signalling pathways activated by various biological agents. Resorption of cementum is regulated by mechanisms similar to those controlling osteoclastogenesis and bone resorption. Following root resorption there is repair by cellular cementum, but factors mediating the transition from resorption to repair are not clear. In this paper we review some of the biological events associated with orthodontically induced external root resorption.
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Liviu
0000-0001-8209-153X
L
Feller
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Razia A G
0000-0002-8599-8249
RA
Khammissa
Private Practice, 15 School Road, Corner Rivonia Road, Morningside, Johannesburg, South Africa.
George
G
Thomadakis
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Jeanine
J
Fourie
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Johan
J
Lemmer
D003739:Dental Cementum; D006801:Humans; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology*; D010513:Periodontal Ligament / Q000503:physiopathology / Q000648:ultrastructure; D012391:Root Resorption / Q000503:physiopathology*; D014087:Tooth Movement Techniques; D014092:Tooth Root / Q000503:physiopathology* / Q000648:ultrastructure; D014945:Wound Healing; D055114:X-Ray Microtomography