Spectrum of Common α-Globin Deletion Mutations in the Southern Region of Vietnam.
The common deletion mutations of α-globin genes in the Vietnamese population is not well known. Here we report the presence of five deletional mutations of Southeast Asia in the southern region of Vietnam. The - -(SEA) (NG_000006.1: g.26264_45564del19301) mutation is the most common type of deletion (87.35%), followed by the -α(3.7) (rightward) (NG_000006.1: g.34164_37967del3804) deletion (9.64%), -α(4.2) (leftward) (AF221717) deletion (2.41%) and - -(THAI) (NG_000006.1: g.10664_44164del33501) (0.6%) mutation in this region. The - -(FIL) (NG_000006.1: g.11684_43534del31581) mutation was not detected in this study. This result provided a view of the distribution of common α-globin gene mutations in Vietnam and could serve as a baseline for further investigations into these genetic defects.
a Department of Applied Sciences , Ho Chi Minh City Blood Transfusion Hematology Hospital , Ho Chi Minh City , Vietnam .
Ly
L
Bui Thi Kim
b Department of First Pediatric Hematology , Ho Chi Minh City Blood Transfusion and Hematology Hospital , Ho Chi Minh City , Vietnam .
Dung
D
Phu Chi
c Department for Management of Science and Technology Development , Ton Duc Thang University , Ho Chi Minh City , Vietnam.|d Faculty of Applied Sciences , Ton Duc Thang University , Ho Chi Minh City , Vietnam.
Chi
C
Hoang Thanh
D006801:Humans; D017720:Molecular Epidemiology; D009154:Mutation; D017384:Sequence Deletion / Q000235:genetics*; D014744:Vietnam / Q000453:epidemiology; D055542:alpha-Globins / Q000235:genetics*; D017085:alpha-Thalassemia / Q000235:genetics
D055542:alpha-Globins
Vietnam; α-Globin genes; α-thalassemia (α-thal)