Effect of prebiotics of Agave salmiana fed to healthy Wistar rats.
BACKGROUND
Inulin and other fructans are synthesized and stored in mezcal agave (Agave salmiana). Fructans provide several health benefits and have excellent technological properties, but only few data report their physiological effect when added in the diet.


RESULTS
Here, we studied the physiological effects of fructans obtained from A. salmiana when added in the diet of Wistar rats. Results showed favorable changes on Wistar rats when the fructans was added to their diet, including the decrease of the pH in the feces and the increase of the number of lactic acid bacteria (CFU g-1) (Lactobacillus spp. and Bifidobacterium spp.), even these changes were enhanced with the synbiotic diet (fructans plus B. animalis subsp. lactis). Synbiotic diet, developed changes in the reduction of cholesterol and triglycerides concentrations in serum, with statistical differences (P < 0.05). Histological analysis of colon sections showed that synbiotic diet promoted colon cells growth suggesting that fructans from A. salmiana confer beneficial health effects through gut microbiota modulation.


CONCLUSIONS
Our data underline the advantage of targeting the gut microbiota by colonic nutrients like specific structure of fructans from A. salmiana, with their beneficial effects. More studies are necessary to define the role of fructans to develop more solid therapeutic solutions in humans. © 2016 Society of Chemical Industry.
Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico.
Iliana
I
Jasso-Padilla
Instituto de Investigacion de Zonas Deserticas, Universidad Autonoma de San Luis Potosi, Mexico.
Bertha
B
Juárez-Flores
Instituto de Investigacion de Zonas Deserticas, Universidad Autonoma de San Luis Potosi, Mexico.
Gregorio
G
Alvarez-Fuentes
Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico.
Alejandro
A
De la Cruz-Martínez
Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico.
José
J
González-Ramírez
Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico.
Mario
M
Moscosa-Santillán
Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico.
Marco
M
González-Chávez
Departamento de Patologia, Hospital Central, Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico.
Cuauhtemoc
C
Oros-Ovalle
Justus Liebig University Giessen, Institute of Food Chemistry and Food Biotechnology, Giessen, Germany.
Florian
F
Prell
Justus Liebig University Giessen, Institute of Food Chemistry and Food Biotechnology, Giessen, Germany.|University of Applied Sciences Mittelhessen, Institute of Bioprocess Engineering and Pharmaceutical Technology, Giessen, Germany.
Peter
P
Czermak
Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico.
Fidel
F
Martinez-Gutierrez
D027882:Agave / Q000737:chemistry* / Q000254:growth & development; D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development / Q000302:isolation & purification; D000069982:Bifidobacterium animalis / Q000254:growth & development; D003106:Colon / Q000166:cytology / Q000382:microbiology / Q000473:pathology; D064806:Dysbiosis / Q000097:blood / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005612:Freeze Drying; D005630:Fructans / Q000302:isolation & purification / Q000627:therapeutic use*; D005638:Fruit / Q000737:chemistry* / Q000254:growth & development; D000069196:Gastrointestinal Microbiome; D006863:Hydrogen-Ion Concentration; D006949:Hyperlipidemias / Q000097:blood / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D007413:Intestinal Mucosa / Q000166:cytology / Q000382:microbiology / Q000473:pathology; D007778:Lactobacillus / Q000254:growth & development / Q000302:isolation & purification; D008297:Male; D008800:Mexico; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D056692:Prebiotics; D011897:Random Allocation; D017208:Rats, Wistar; D058616:Synbiotics
D005630:Fructans; D010936:Plant Extracts; D056692:Prebiotics
cholesterol; colon cells; fructans; lactic acid bacteria; triglycerides