Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8-C29 Fragment.
A synthesis of the C8-C29 fragment of amphidinolide N, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been achieved. The key features of the synthesis involve a convergent union of the C9-C15 and C16-C29 fragments by Steglich esterification and the construction of a pyran unit through a Tebbe methylenation/ring-closing metathesis sequence.
Graduate School of Life Sciences, Tohoku University , 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Yuki
Y
Kawashima
Graduate School of Life Sciences, Tohoku University , 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Atsushi
A
Toyoshima
Graduate School of Life Sciences, Tohoku University , 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Haruhiko
H
Fuwa
Graduate School of Life Sciences, Tohoku University , 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Makoto
M
Sasaki