HIV-Positive-to-HIV-Positive Liver Transplantation.
Most countries exclude human immunodeficiency virus (HIV)-positive patients from organ donation because of concerns regarding donor-derived HIV transmission. The Swiss Federal Act on Transplantation has allowed organ transplantation between HIV-positive donors and recipients since 2007. We report the successful liver transplantation from an HIV-positive donor to an HIV-positive recipient. Both donor and recipient had been treated for many years with antiretroviral therapy and harbored multidrug-resistant viruses. Five months after transplantation, HIV viremia remains undetectable. This observation supports the inclusion of appropriate HIV-positive donors for transplants specifically allocated to HIV-positive recipients.
HIV Unit, Geneva University Hospitals, Geneva, Switzerland.
A
A
Calmy
Transplant Infectious Diseases Unit, Geneva University Hospitals, Geneva, Switzerland.
C
C
van Delden
Division of Transplantation, Geneva University Hospitals, Geneva, Switzerland.
E
E
Giostra
Private Practice, Geneva, Switzerland.
C
C
Junet
Division of Pathology, Geneva University Hospitals, Geneva, Switzerland.
L
L
Rubbia Brandt
Virology Laboratory, Geneva University Hospitals, Geneva, Switzerland.
S
S
Yerly
Private Practice, Lausanne, Switzerland.
J-P
JP
Chave
Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland.
C
C
Samer
Division of Transplantation, Geneva University Hospitals, Geneva, Switzerland.
L
L
Elkrief
Division of Gastroenterology and Division of Transplantation, CHUV, Lausanne, Switzerland.
J
J
Vionnet
Division of Transplantation, Geneva University Hospitals, Geneva, Switzerland.
T
T
Berney
D000368:Aged; D006085:Graft Survival / Q000276:immunology*; D015658:HIV Infections / Q000601:surgery* / Q000821:virology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement
clinical research/practice; ethics and public policy; immune deficiency; infectious disease; patient safety