Medical Functions of Hydrogen Sulfide.
Hydrogen sulfide (H(2)S) is a gasomediator synthesized from L- and D-cysteine in various tissues. It is involved in a number of physiological and pathological processes. H(2)S exhibits antiatherosclerotic, vasodilator, and proangiogenic properties, and protects the kidney and heart from damage following ischemia/reperfusion injury. H(2)S donors may be natural or synthetic, and may be used for the safe treatment of a wide range of diseases. This review article summarizes the current state of knowledge of the therapeutic function of H(2)S.
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland. Electronic address: olasb@biol.uni.lodz.pl.
Beata
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Olas
D043925:Angiogenesis Inducing Agents / Q000378:metabolism / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000378:metabolism / Q000627:therapeutic use*; D003545:Cysteine / Q000378:metabolism; D004008:Diclofenac / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use; D004220:Disulfides / Q000378:metabolism / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007980:Levodopa / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use; D011461:Prostaglandins F, Synthetic / Q000378:metabolism / Q000627:therapeutic use; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D013440:Sulfides / Q000378:metabolism / Q000627:therapeutic use; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use; D013871:Thiones / Q000378:metabolism / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000378:metabolism / Q000627:therapeutic use*
C573318:2-((2,6-dichlorophenyl)amino) benzeneacetic acid 4-(3-thioxo-3H-1,2-dithiol-5-yl) phenyl ester; C583845:ACS 84; C546828:ACS67 compound; D043925:Angiogenesis Inducing Agents; D002317:Cardiovascular Agents; D004220:Disulfides; D011461:Prostaglandins F, Synthetic; D013440:Sulfides; D013871:Thiones; D014665:Vasodilator Agents; D004008:Diclofenac; D007980:Levodopa; D008063:Thioctic Acid; C025451:sodium bisulfide; D003545:Cysteine; C033479:sodium sulfide; D006862:Hydrogen Sulfide
Gasotransmitter; H(2)S donor; Hydrogen sulfide