Interaction between 25-hydroxyvitamin D and variants at 17q12-21 on respiratory infections.
25-hydroxyvitamin D (25[OH]D) deficiency and genetic variants at the 17q12-21 locus are independent risk factors for respiratory tract infections (RTIs). We aimed to investigate whether the effect of 25(OH)D at birth and 1 year of age and the polymorphism at the 17q12-21 locus, or interactions between these two factors, increase susceptibility to RTIs in the first year of life.



We tested cord-blood (CB) 25(OH)D at birth and 1 year of age and genotypes of a variant at the 17q12-21 locus for associations with RTIs, particularly lower respiratory tract infections (LRTIs), and determined whether there exist interactions between 25(OH)D and 17q12-21 genotypes in a birth cohort of 473 infants.



The levels of CB 25(OH)D inversely associate with development of RTIs and LRTIs during the first year of life. There exists an inverse association of 25(OH)D at birth, but not at 1 year, with the risk of acquiring LRTIs in early infancy (adjusted odds ratio [aOR], 2.37; 95% confidence interval [CI]: 1.23-4.60; P = 0.010 and aOR, 0.50; 95%CI: 0.23-1.12; P = 0.094). We have also found a significant interaction between CB 25(OH)D and a variant at the 17q12-21 locus with respect to the development of early LRTIs, such that associations between a variant at the 17q12-21 locus and LRTIs are restricted to infants with low CB 25(OH)D concentrations (P for interaction = 0.013). In addition, when infants with a variant at the 17q12-21 locus had been exposed to chronic 25(OH)D deficiency over the first year, their risk of LRTIs was increased.



CB 25(OH)D deficiency during fetal life contribute to the development of LRTIs in genetically susceptible infants. Pediatr Pulmonol. 2016; 51:958-967. © 2016 Wiley Periodicals, Inc.
Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
Youn Ho
YH
Sheen
Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.
Eun
E
Lee
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Mi-Jin
MJ
Kang
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Ho-Sung
HS
Yu
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, and the Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea.
Kangmo
K
Ahn
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Kyung Won
KW
Kim
Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Song-I
SI
Yang
Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
Young-Ho
YH
Jung
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Kyung-Ju
KJ
Lee
Department of Psychiatry, Ajou University School of Medicine, Suwon, Korea.
Hyoung Yoon
HY
Chang
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Hye Lim
HL
Shin
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Kil Yong
KY
Choi
Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea.
Hyung Young
HY
Kim
Department of Pediatrics, Korea Cancer Center, Seoul, Korea.
Ju-Hee
JH
Seo
Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
Ji-Won
JW
Kwon
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Byoung-Ju
BJ
Kim
Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
Hyo-Bin
HB
Kim
Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
So-Yeon
SY
Lee
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Dong In
DI
Suh
Department of Pediatrics, Soonchunhyang University School of Medicine, Seoul, Korea.
Hyeon-Jong
HJ
Yang
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Suk-Joo
SJ
Choi
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Soo-Young
SY
Oh
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Ja-Young
JY
Kwon
Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
Soo Hyun
SH
Kim
Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hye-Sung
HS
Won
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Science, Korea National Institute of Health, Cheongju, Korea.
Eun-Jin
EJ
Kim
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Science, Korea National Institute of Health, Cheongju, Korea.
Jeom Kyu
JK
Lee
Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Soo-Jong
SJ
Hong
D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000150:complications* / Q000235:genetics*; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications*
D014807:Vitamin D; C104450:25-hydroxyvitamin D
17q12-21; cohort study; gene-environment interaction; polymorphism; prenatal programming; respiratory tract infections; vitamin D