Early removal versus expectant management of central venous catheters in neonates with bloodstream infection.
BACKGROUND
Uncertainty exists regarding the management of newborn infants with a bloodstream infection and a central venous catheter in place. The central venous catheter may act as a nidus for infecting organisms and observational studies have suggested that early removal of the catheter is associated with a lower incidence of persistent or complicated infection. However, since central venous catheters provide secure vascular access to deliver nutrition and medications, the possible harms of early removal versus expectant management also need to be considered.


OBJECTIVE
To determine the effect of early removal versus expectant management of central venous catheters on morbidity and mortality in newborn infants with bloodstream infections.


METHODS
We used the standard search strategy of the Cochrane Neonatal Review Group. This included searches of the Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 11), MEDLINE (1966 to October 2015), EMBASE (1980 to October 2015), CINAHL (1982 to October 2015), conference proceedings and previous reviews.


METHODS
Randomised and quasi-randomised controlled trials that compared early removal versus expectant management of central venous catheters in neonates with bloodstream infections.


METHODS
We used the standard methods of the Cochrane Neonatal Review Group.


RESULTS
We did not identify any eligible randomised controlled trials.


CONCLUSIONS
There are no trial data to guide practice regarding early removal versus expectant management of central venous catheters in newborn infants with bloodstream infections. A simple and pragmatic randomised controlled trial is needed to resolve the uncertainty about optimal management in this common and important clinical scenario.
University of Leeds, Leeds, UK, LS2 9JT.
Chakrapani
C
Vasudevan
Sam J
SJ
Oddie
William
W
McGuire
D016470:Bacteremia; D055499:Catheter-Related Infections / Q000097:blood* / Q000517:prevention & control; D002405:Catheterization, Central Venous / Q000295:instrumentation*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D020878:Device Removal / Q000592:standards*; D006801:Humans; D007231:Infant, Newborn; D013997:Time Factors; D057832:Watchful Waiting