Predicting Conformational Disorder.
In the last two decades, it has become increasingly evident that a large number of proteins are either fully or partially disordered. Intrinsically disordered proteins are ubiquitous proteins that fulfill essential biological functions while lacking a stable 3D structure. Their conformational heterogeneity is encoded at the amino acid sequence level, thereby allowing intrinsically disordered proteins or regions to be recognized based on their sequence properties. The identification of disordered regions facilitates the functional annotation of proteins and is instrumental for delineating boundaries of protein domains amenable to crystallization. This chapter focuses on the methods currently employed for predicting disorder and identifying regions involved in induced folding.
AFMB UMR 7257, Aix-Marseille Université, 163, avenue de Luminy, Case 932, 13288, Marseille Cedex 09, France.|AFMB UMR 7257, CNRS, 163, avenue de Luminy, Case 932, 13288, Marseille Cedex 09, France.
Philippe
P
Lieutaud
AFMB UMR 7257, Aix-Marseille Université, 163, avenue de Luminy, Case 932, 13288, Marseille Cedex 09, France.|AFMB UMR 7257, CNRS, 163, avenue de Luminy, Case 932, 13288, Marseille Cedex 09, France.
François
F
Ferron
AFMB UMR 7257, Aix-Marseille Université, 163, avenue de Luminy, Case 932, 13288, Marseille Cedex 09, France. Sonia.Longhi@afmb.univ-mrs.fr.|AFMB UMR 7257, CNRS, 163, avenue de Luminy, Case 932, 13288, Marseille Cedex 09, France. Sonia.Longhi@afmb.univ-mrs.fr.
Sonia
S
Longhi
D000595:Amino Acid Sequence; D019295:Computational Biology / Q000379:methods*; D018360:Crystallography, X-Ray; D030562:Databases, Protein; D020407:Internet; D064267:Intrinsically Disordered Proteins / Q000737:chemistry*; D008958:Models, Molecular; D058977:Molecular Sequence Annotation; D011487:Protein Conformation; D000072417:Protein Domains; D017510:Protein Folding
D064267:Intrinsically Disordered Proteins
Disorder databases and metaservers; Induced folding; Intrinsic disorder; Intrinsically disordered proteins; Intrinsically disordered regions; Prediction methods