Major transfusions remain frequent despite the generalized use of tranexamic acid: an audit of 3322 patients undergoing cardiac surgery.
Aprotinin has been reapproved for use in Europe and in Canada. We sought to determine if its reintroduction was still pertinent given the widespread administration of tranexamic acid, another antifibrinolytic shown to reduce bleeding and transfusions.



After institutional review board approval, we examined the cardiac surgery database (2012-2015; 3322 patients). Major transfusion was defined as 4 or more red blood cell units. A stratified multivariate logistic regression analysis identified predictors of major transfusion; 1064 patients were matched by propensity score to compare outcomes of patients with or without major transfusion.



Cardiopulmonary bypass (CPB) was used in 2342 patients; 98.9% received tranexamic acid versus 15.2% (149/980) in off-pump coronary artery bypass graft patients. Major transfusion was required in 758 patients (23%). Age, low body mass index, low preoperative hemoglobin or platelet count, recent use of P2Y12 receptor blockers, chronic kidney disease, NYHA functional class, left ventricular ejection fraction of less than 30%, prior cardiac surgery, urgency, type of cardiac surgery, and duration of CPB were all independent predictors of major transfusions (all p < 0.05). Major transfusion was associated with a more than threefold increase in mortality (7.1% vs. 2.1%; p < 0.001) and increases in major adverse events (p < 0.001).



Despite the use of tranexamic acid, 23% of cardiac surgery patients require a major transfusion. We identified predictors of major transfusion and showed that major transfusion is associated with important increases in mortality and morbidity. We conclude that there is still a need for an effective and safe blood-sparing drug in cardiac surgery.
Division of Cardiac Surgery and the, Centre Hospitalier de l'Université de Montréal (CHUM).|Department of Anesthesiology, Centre Hospitalier de l'Université de Montréal (CHUM).|CHUM Research Center (CRCHUM), Montréal, Québec, Canada.
Louis-Mathieu
LM
Stevens
Division of Cardiac Surgery and the, Centre Hospitalier de l'Université de Montréal (CHUM).|Department of Anesthesiology, Centre Hospitalier de l'Université de Montréal (CHUM).|CHUM Research Center (CRCHUM), Montréal, Québec, Canada.
Nicolas
N
Noiseux
Division of Cardiac Surgery and the, Centre Hospitalier de l'Université de Montréal (CHUM).
Ignacio
I
Prieto
Department of Anesthesiology, Centre Hospitalier de l'Université de Montréal (CHUM).|CHUM Research Center (CRCHUM), Montréal, Québec, Canada.
Jean-François
JF
Hardy
D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D007611:Aprotinin / Q000627:therapeutic use; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D016208:Databases, Factual; D006470:Hemorrhage / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D006801:Humans; D019990:Perioperative Care / Q000379:methods; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D057216:Propensity Score; D012189:Retrospective Studies; D012307:Risk Factors; D014148:Tranexamic Acid / Q000627:therapeutic use*
D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid; D007611:Aprotinin