Outcomes of colon resection in patients with metastatic colon cancer.
BACKGROUND
Patients with advanced colorectal cancer have a high incidence of postoperative complications. We sought to identify outcomes of patients who underwent resection for colon cancer by cancer stage.


METHODS
The National Surgical Quality Improvement Program database was used to evaluate all patients who underwent colon resection with a diagnosis of colon cancer from 2012 to 2014. Multivariate logistic regression analysis was performed to investigate patient outcomes by cancer stage.


RESULTS
A total of 7,786 colon cancer patients who underwent colon resection were identified. Of these, 10.8% had metastasis at the time of operation. Patients with metastatic disease had significantly increased risks of perioperative morbidity (adjusted odds ratio [AOR]: 1.44, P = .01) and mortality (AOR: 3.72, P = .01). Patients with metastatic disease were significantly younger (AOR: .99, P < .01) had a higher American Society of Anesthesiologists score (AOR: 1.29, P < .2) and had a higher rate of emergent operation (AOR: 1.40, P < .01).


CONCLUSIONS
Overall, 10.8% of patients undergoing colectomy for colon cancer have metastatic disease. Postoperative morbidity and mortality are significantly higher than in patients with localized disease.
Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA.
Zhobin
Z
Moghadamyeghaneh
Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA.
Mark H
MH
Hanna
Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA.
Grace
G
Hwang
Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA.
Steven
S
Mills
Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA.
Alessio
A
Pigazzi
Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA.
Michael J
MJ
Stamos
Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA. Electronic address: jcarmich@uci.edu.
Joseph C
JC
Carmichael
D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy; D003106:Colon / Q000473:pathology / Q000601:surgery*; D003110:Colonic Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016896:Treatment Outcome
Colon cancer; Disseminated cancer; Metastatic colon cancer