Directing lipid transport at membrane contact sites.
Contact sites between the endoplasmic reticulum and the plasma membrane mediate receptor signalling. How this function is controlled physically and functionally is poorly understood. Extended synaptotagmins are now shown to shuttle the lipid metabolite diacylglycerol from the plasma membrane to the endoplasmic reticulum in receptor-stimulated cells.
Leibniz Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125 Berlin.
Michael
M
Krauβ
Leibniz Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125 Berlin.|Freie Universität Berlin, Faculty of Biology, Chemistry, Pharmacy, 14195 Berlin.
Volker
V
Haucke
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane; D004721:Endoplasmic Reticulum; D008055:Lipids; D050857:Synaptotagmins
D008055:Lipids; D050857:Synaptotagmins