Early Intervention with Highly Condensed Adipose-Derived Stem Cells for Complicated Wounds Following Filler Injections.
BACKGROUND
A rise in cosmetic procedures has seen the use of fillers become more prevalent. Complications resulting from use of fillers have prompted introduction of various medical and surgical interventions. Recently, stem cell therapies have become more widely used as a new treatment option for tissue repair and regeneration.


METHODS
We utilized adipose-derived stem cells (ASCs) for tissue regeneration in patients with filler-related complications such as necrosis. All 12 patients were treated with ASCs and some patients had additional treatment. After relief of symptoms, wound surface area was compared in terms of pixel numbers and scar condition was evaluated using the Vancouver Scar Scale (VSS).


RESULTS
In general, we achieved satisfactory resolution of filler-related complications in a short period of time without serious side effects. The average number of days from stem cell treatment to symptom relief was 7.3 days. The proportion of wound surface area from photographic record was 4.39 % before treatment, decreasing considerably to 1.01 % following treatment. Last, the VSS showed almost all patients scored below 3, with two patients receiving scores of 7 and 8; the average score was 2.78 (range from 0 to 8).


CONCLUSIONS
ASCs are a new treatment option for post-filler injection wounds such as necrosis. Using stem cells, we were able to obtain satisfactory results in a short period of time without complications requiring surgical procedures. We suggest stem cell injections could be used as the first option for treatment of complications from filler injections.


METHODS
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Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University Medical Center, 1, Singil-ro, Yeongdeungpo-gu, Seoul, 07441, Korea.
Joo Hyun
JH
Kim
Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University Medical Center, 1, Singil-ro, Yeongdeungpo-gu, Seoul, 07441, Korea.
Seong Hoon
SH
Park
Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University Medical Center, 1, Singil-ro, Yeongdeungpo-gu, Seoul, 07441, Korea.
Byeong Ho
BH
Lee
Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University Medical Center, 1, Singil-ro, Yeongdeungpo-gu, Seoul, 07441, Korea.
Hii Sun
HS
Jeong
Baroil Aesthetic Plastic Surgical Clinic, Seoul, Korea.
Hyun Jin
HJ
Yang
Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University Medical Center, 1, Singil-ro, Yeongdeungpo-gu, Seoul, 07441, Korea. sismdps@hallym.or.kr.
In Suck
IS
Suh
D017667:Adipocytes / Q000637:transplantation*; D000328:Adult; D015331:Cohort Studies; D003357:Cosmetic Techniques / Q000009:adverse effects*; D000067548:Dermal Fillers / Q000009:adverse effects*; D004954:Esthetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies; D018570:Risk Assessment; D012867:Skin / Q000473:pathology*; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
D000067548:Dermal Fillers
Adipose-derived stem cells; Filler complication; Necrosis; Tissue repair