Symmetric ambulatory arterial stiffness index in the young.
The ambulatory arterial stiffness index (AASI) and the symmetric ambulatory arterial stiffness index (s-AASI) have been shown to correlate to arterial stiffness in adults. This study assesses these indices with anthropometric and blood pressure (BP) measures in children. A total of 102 children at a pediatric hypertension clinic who had ambulatory blood pressure monitoring (ABPM) done from 2009 to 2013 were included (75% males, 7-22yo, 47% hypertensive, 24% prehypertensive, and 34% white-coat hypertensives). AASI is 1 minus the regression slope of diastolic BP values on systolic BP values from a 24-hour ambulatory blood pressure monitoring. s-AASI is the symmetric regression of AASI. Obese patients had a significantly higher AASI. s-AASI correlated with systolic BP variability. In multivariable regression, BP variability independently correlated with AASI and s-AASI. s-AASI is related to systolic dipping.AASI and s-AASI are highly dependent on BP variability in children. Further studies are necessary to assess their utility.
Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, USA.
Minh B
MB
Nguyen
Hofstra North Shore-LIJ School of Medicine, Cohen Children's Medical Center, NY, USA.
Pamela
P
Singer
Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, USA.
Fredrick
F
Kaskel
Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, USA. Electronic address: jmahgere@montefiore.org.
Joseph
J
Mahgerefteh
D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002648:Child; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D063766:Pediatric Obesity / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D059289:Vascular Stiffness; D059466:White Coat Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D055815:Young Adult
AASI; hypertension; obesity; pediatrics