Response to chemotherapy with carboplatin plus albumin-bound paclitaxel in a patient with lymphoepithelioma-like thymic carcinoma: A case report.
Thymic carcinoma is a rare neoplasm with a poor outcome due to its aggressive characteristics. For patients who are not operable, radiation therapy and/or palliative chemotherapy are indicated. However, no optimal chemotherapy regimen has been established. The present study reports the case of a 22-year-old man with advanced lymphoepithelioma-like thymic carcinoma refractory to conventional chemotherapy with carboplatin plus solvent-based paclitaxel (sb-PAC) treatment. The patient was subsequently treated with carboplatin plus nanoparticle albumin-bound paclitaxel (nab-PAC). The treatment resulted in a partial response following three cycles of chemotherapy. Since only grade 3 neutropenia, but no other severe adverse effects, was observed, no dose reduction was required. To the best of our knowledge, the current study is the first to present the response to chemotherapy with carboplatin plus nab-PAC in a patient with lymphoepithelioma-like thymic carcinoma. Considering that no standard treatment has been established in thymic carcinoma, nab-PAC may merit further investigation in this rare, but aggressive disease.
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Hiroshi
H
Shima
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Hiroaki
H
Ozasa
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Takahiro
T
Tsuji
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Hitomi
H
Ajimizu
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Takashi
T
Nomizo
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Yoshitaka
Y
Yagi
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Yuichi
Y
Sakamori
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Hiroki
H
Nagai
Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Sachiko
S
Minamiguchi
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Young Hak
YH
Kim
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Michiaki
M
Mishima
albumin-bound paclitaxel; lymphoepithelioma-like carcinoma; nab-PAC; thymic carcinoma