Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: Associations of myocardial strain with myocardial region, age, and sex.
To assess myocardial strain using cine displacement encoding with stimulated echoes (DENSE) using 1.5T and 3.0T MRI in healthy adults.



Healthy adults without any history of cardiovascular disease underwent magnetic resonance imaging (MRI) at 1.5T and 3.0T within 2 days. The MRI protocol included balanced steady-state free-precession (b-SSFP), 2D cine-echo planar imaging (EPI)-DENSE, and late gadolinium enhancement in subjects >45 years. Acquisitions were divided into six segments; global and segmental peak longitudinal and circumferential strain were derived and analyzed by field strength, age, and gender.



In all, 89 volunteers (mean age 44.8 ± 18.0 years, range: 18-87 years) underwent MRI at 1.5T, and 88 of these subjects underwent MRI at 3.0T (1.4 ± 1.4 days between the scans). Compared with 3.0T, the magnitudes of global circumferential (-19.5 ± 2.6% vs. -18.47 ± 2.6%; P = 0.001) and longitudinal (-12.47 ± 3.2% vs. -10.53 ± 3.1%; P = 0.004) strain were greater at 1.5T. At 1.5T, longitudinal strain was greater in females than in males: -10.17 ± 3.4% vs. -13.67 ± 2.4%; P = 0.001. Similar observations occurred for circumferential strain at 1.5T (-18.72 ± 2.2% vs. -20.10 ± 2.7%; P = 0.014) and at 3.0T (-17.92 ± 1.8% vs. -19.1 ± 3.1%; P = 0.047). At 1.5T, longitudinal and circumferential strain were not associated with age after accounting for sex (longitudinal strain P = 0.178, circumferential strain P = 0.733). At 3.0T, longitudinal and circumferential strain were associated with age (P < 0.05). Longitudinal strain values were greater in the apico-septal, basal-lateral, and mid-lateral segments and circumferential strain in the inferior, infero-lateral, and antero-lateral LV segments.



Myocardial strain parameters as revealed by cine-DENSE at different MRI field strengths were associated with myocardial region, age, and sex. J. Magn. Reson. Imaging 2016;44:1197-1205.
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.|West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
Kenneth
K
Mangion
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
Guillaume
G
Clerfond
Clinical Physics, NHS Greater Glasgow and Clyde, Glasgow, UK.
Christie
C
McComb
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.|West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
David
D
Carrick
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
Samuli M
SM
Rauhalammi
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
John
J
McClure
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.|West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
David S
DS
Corcoran
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
Rosemary
R
Woodward
West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
Vanessa
V
Orchard
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
Aleksandra
A
Radjenovic
MR R&D Collaborations, Siemens Healthcare, Atlanta, Georgia, USA.
Xiaodong
X
Zhong
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK. colin.berry@glasgow.ac.uk.|West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK. colin.berry@glasgow.ac.uk.
Colin
C
Berry
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D016880:Anisotropy; D019245:Compressive Strength / Q000502:physiology; D055119:Elastic Modulus / Q000502:physiology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult
displacement encoding with stimulated echoes; healthy volunteers; myocardial strain