Malignant Glomus Tumour (Glomangiosarcoma) with Additional Neuroendocrine Differentiation in a Horse.
A 13-year-old Icelandic crossbred horse was presented with headshaking and progressive impairment of chewing. A slowly growing mass was identified in the anterior maxilla. This was associated with lysis of the alveolar bone and the roots of the incisors and there were nodular proliferations affecting the nasal septum and conchae. There was no response to chemotherapy and so the horse was humanely destroyed. Based on morphological, immunohistochemical and ultrastructural findings the mass was classified as a malignant glomus tumour with multifocal vascular spaces and additional neuroendocrine differentiation. An oronasal glomus tumour with neuroendocrine differentiation has not been described previously in an animal.
Chemisches und Veterinäruntersuchungsamt Westfalen, Zur Taubeneiche 10-12, Arnsberg, Germany.
M
M
Peters
Veterinary Practice for Horses, Dortmund, Germany.
J
J
Grafen
Institute of Pathology, Medical Center Düesbergweg 128, Münster, Germany.
C
C
Kuhnen
Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, Hannover, Germany. Electronic address: peter.wohlsein@tiho-hannover.de.
P
P
Wohlsein
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002454:Cell Differentiation; D005260:Female; D005918:Glomus Tumor / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry; D008441:Maxillary Neoplasms / Q000662:veterinary*
D014408:Biomarkers, Tumor
horse; malignant glomus tumour; nasal cavity; oral cavity