Effects of gossypol from cottonseed cake on the blood profile in sheep.
Cottonseed cake contains gossypol, a potentially toxic compound that, when consumed by sheep, can affect reproduction, the immune system, and the liver. Changes in hematologic and serum biochemical parameters were monitored for 63 days in 12 Santa Inês ewes, six of which received ration containing 400 g kg(-1) of cottonseed cake. Blood samples were collected at the start of the experiment and weekly thereafter for hematologic assessment and determination of serum urea, creatinine, total protein, and albumin concentrations and for measurement of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transferase activities. No clinical signs of toxicity were observed. Evaluation of the erythron showed that sheep consuming cottonseed cake had an increased packed cell volume (p < 0.05) and increased erythrocyte counts and hemoglobin concentrations (p < 0.05) in the leukogram and serum biochemistry panel. In conclusion, consumption of 400 g kg(-1) cottonseed cake by sheep for 63 days may induce changes in the erythron but no consistent changes in serum biochemical parameters, indicating no damage to the liver or kidneys.
Hospital Veterinário, Universidade Federal Rural do Semi-Árido (UFERSA), Av. Francisco Mota 572, Mossoró, RN, 59625-900, Brazil.
Antônio Carlos Lopes
AC
Câmara
Hospital Veterinário, Universidade Federal Rural do Semi-Árido (UFERSA), Av. Francisco Mota 572, Mossoró, RN, 59625-900, Brazil.
André Menezes
AM
do Vale
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil.
Cláudio Roberto Scabelo
CR
Mattoso
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil.
Marília Martins
MM
Melo
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil. benito.blanco@pq.cnpq.br.
Benito
B
Soto-Blanco
D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D004032:Diet / Q000662:veterinary; D005260:Female; D006072:Gossypol / Q000009:adverse effects*; D006403:Hematologic Tests / Q000662:veterinary; D034561:Sheep, Domestic / Q000097:blood*
D006072:Gossypol
Antinutritional factor; Cotton; Gossypium spp.; Gossypol