Association of CYBA G640A variation with coronary artery disease in Indians.
BACKGROUND
Oxidative stress induces atherosclerosis by triggering an inflammatory cascade within the vascular wall.


OBJECTIVE
To investigate the role of pro-oxidant and antioxidant gene variations with CAD in Indian subjects.


METHODS
It's a case-control study and genotyping for the variants MPO G-463A, CYBA G640A, SOD2 Val16Ala and CAT C-262T were performed by conventional PCR techniques.


RESULTS
Only CYBA G640A variant allele was found to be significantly (p = 0.0075) associated with CAD.


CONCLUSIONS
Although CYBA G640A variation was found to be significant, a larger study is needed to validate these results and establish its role as a biomarker.
a Research Laboratories , P.D. Hinduja Hospital & MRC , Mumbai , Maharashtra , India.
Sripriya
S
Natarajan
b Department of Medicine , P. D. Hinduja Hospital & MRC , Mumbai , Maharashtra , India.
Chandrashekhar K
CK
Ponde
b Department of Medicine , P. D. Hinduja Hospital & MRC , Mumbai , Maharashtra , India.
Rajesh M
RM
Rajani
a Research Laboratories , P.D. Hinduja Hospital & MRC , Mumbai , Maharashtra , India.|c Department of Lab Medicine , P. D. Hinduja Hospital & MRC, Department of Lab Medicine , Mumbai , Maharashtra , India.
Tester F
TF
Ashavaid
CYBA; Coronary artery disease; Indians; gene polymorphisms; oxidative stress