Readmission Following Gastric Cancer Resection: Risk Factors and Survival.
This study utilized a multi-institutional database to evaluate risk factors for readmission in patients undergoing curative gastrectomy for gastric adenocarcinoma with the intent of describing both perioperative risk factors and the relationship of readmission to survival.



Patients who underwent curative resection of gastric adenocarcinoma from 2000 to 2012 from seven academic institutions of the US Gastric Cancer Collaborative were analyzed. In-hospital deaths and palliative surgeries were excluded, and readmission was defined as within 30 days of discharge. Univariate and multivariable logistic regression analyses were employed and survival analysis conducted.



Of the 855 patients, 121 patients (14.2 %) were readmitted. Univariate analysis identified advanced age (p < 0.0128), American Society of Anesthesiology status ≥3 (p = 0.0045), preexisting cardiac disease (p < 0.0001), hypertension (p = 0.0142), history of smoking (p = 0.0254), increased preoperative blood urea nitrogen (BUN; p = 0.0426), concomitant pancreatectomy (p = 0.0056), increased operation time (p = 0.0384), estimated blood loss (p = 0.0196), 25th percentile length of stay (<7 days, p = 0.0166), 75th percentile length of stay (>12 days, p = 0.0256), postoperative complication (p < 0.0001), and total gastrectomy (p = 0.0167) as risk factors for readmission. Multivariable analysis identified cardiac disease (odds ratio (OR) 2.4, 95 % confidence interval (CI) 1.6-3.3, p < 0.0001), postoperative complication (OR 2.3, 95 % CI 1.6-5.4, p < 0.0001), and pancreatectomy (OR 2.2, 95 % CI 1.1-4.1, p = 0.0202) as independent risk factors for readmission. There was an association of decreased overall median survival in readmitted patients (39 months for readmitted vs. 103 months for non-readmitted). This was due to decreased survival in readmitted stage 1 (p = 0.0039), while there was no difference in survival for other stages. Stage I readmitted patients had a higher incidence of cardiac disease than stage I non-readmitted patients (58 vs. 24 %, respectively, p = 0.0002).



Within this multi-institutional study investigating readmission in patients undergoing curative resection for gastric cancer, cardiac disease, postoperative complication, and concomitant pancreatectomy were identified as significant risk factors for readmission. Readmission was associated with decreased overall median survival, but on further analysis, this was driven by differences in survival for stage I disease only.
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Alexandra W
AW
Acher
Emory University, Atlanta, GA, USA.
Malcolm H
MH
Squires
Washington University School of Medicine, St. Louis, MO, USA.
Ryan C
RC
Fields
Stanford University, Stanford, CA, USA.
George A
GA
Poultsides
Ohio State University, Columbus, OH, USA.
Carl
C
Schmidt
Wake Forest University, Winston-Salem, NC, USA.
Konstantinos I
KI
Votanopoulos
The Johns Hopkins University, Baltimore, MD, USA.
Timothy M
TM
Pawlik
Washington University School of Medicine, St. Louis, MO, USA.
Linda X
LX
Jin
The Johns Hopkins University, Baltimore, MD, USA.
Aslam
A
Ejaz
Emory University, Atlanta, GA, USA.
David A
DA
Kooby
Ohio State University, Columbus, OH, USA.
Mark
M
Bloomston
Stanford University, Stanford, CA, USA.
David
D
Worhunsky
Wake Forest University, Winston-Salem, NC, USA.
Edward A
EA
Levine
Ohio State University, Columbus, OH, USA.
Neil
N
Saunders
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Emily
E
Winslow
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Clifford S
CS
Cho
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Glen
G
Leverson
Emory University, Atlanta, GA, USA.
Shishir K
SK
Maithel
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. webers@surgery.wisc.edu.|Department of General Surgery, H4/730, 7375 Clinical Science Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA. webers@surgery.wisc.edu.
Sharon M
SM
Weber
D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000401:mortality*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission / Q000706:statistics & numerical data*; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery*; D016019:Survival Analysis
Adenocarcinoma; Gastrectomy; Gastric cancer; Readmission; Risk factors; Survival