Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.
Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one-step ring-opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self-assembles into well-defined nanoparticles with tunable size.
Department of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Jinyao
J
Liu
Department of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Yan
Y
Pang
Department of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Jayanta
J
Bhattacharyya
Department of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Wenge
W
Liu
Department of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Isaac
I
Weitzhandler
Department of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Xinghai
X
Li
Department of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Ashutosh
A
Chilkoti
D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D005260:Female; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry*; D010316:Particle Size; D011355:Prodrugs / Q000737:chemistry*
D004337:Drug Carriers; D011355:Prodrugs; D017239:Paclitaxel
anticancer; nanoparticle; paclitaxel; prodrug; ring-opening polymerization