Antidepressants and Driving in Older Adults: A Systematic Review.
With an increasing number of older drivers who are prescribed antidepressants, the potential consequences of antidepressant use on driving skills in an aging population are becoming a pressing issue. We conducted a systematic review using MEDLINE, targeting articles specifically pertaining to antidepressants and driving in a population or subgroup of older adults (≥ 55 years of age). The search yielded 267 references, nine of which pertained to the effects of antidepressants on driving in older adults. The single experimental study found imipramine to have detrimental effects on highway driving, whereas nefazodone did not. Seven of eight population-based studies reported a significant increased risk of involvement in a collision associated with antidepressant use. Although the studies indicated a negative effect of antidepressants on driving, the epidemiological designs cannot exclude the possibility that the underlying illness, generally major depression, is the culprit.
Sunnybrook Health Sciences Centre; University of Toronto, Department of Psychiatry.
Duncan H
DH
Cameron
Sunnybrook Health Sciences Centre; University of Toronto, Department of Psychiatry.
Mark J
MJ
Rapoport
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001334:Automobile Driving / Q000523:psychology; D015331:Cohort Studies; D018592:Cross-Over Studies; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
D000928:Antidepressive Agents
accidents de la circulation; aging; antidepressive agents; antidépresseuses; aînés; collisions automobiles; conduite; driving; motor vehicle collisions; seniors; traffic; traffic accidents; vieillissment