Transcription factors in the development of inner ear hair cells.
Inner ear hair cells are the sensory receptors that detect and convert sound vibrations and head movements into neural signals. However, in humans, these cells are unable to regenerate if they are damaged or lost. Over thepast decade,there has been an exponential increase in interest and progress in understanding of the development of the inner ear and of hair cells, aiming to gain insights into hair cell repair or even regeneration. In hair cell development, various transcription factors have been found to be involved in the processes of hair cell proliferation, differentiation and survival. Among these transcription factors, Math1, Gata3, Sox2 and Atoh1 have been highlighted for their crucial role in the fate of hair cells. In this article, we will summarize the current understanding of the role of transcription factors in hair cell development, focusing on the role and possible mechanisms of Math1, Gata3, Sox2 and Atoh1.
Department of Otolaryngology and Head-Neck Surgery, Zhenjiang First People's Hospital, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China, lishuna01@yeah.net.
Shuna
S
Li
Department of Otolaryngology and Head-Neck Surgery, Zhenjiang First People's Hospital, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Wei
W
Qian
Department of Otolaryngology and Head-Neck Surgery, Zhenjiang First People's Hospital, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Guochang
G
Jiang
Department of Otolaryngology and Head-Neck Surgery, Zhenjiang First People's Hospital, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Yongming
Y
Ma
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D002454:Cell Differentiation; D050990:GATA3 Transcription Factor / Q000378:metabolism; D006199:Hair Cells, Auditory, Inner / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D055748:SOXB1 Transcription Factors / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D051792:Basic Helix-Loop-Helix Proteins; D050990:GATA3 Transcription Factor; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors