Chasing great paths of Helmut Sies "Oxidative Stress".
Prof. Dr. Helmut Sies is a pioneer of "Oxidative Stress", and has published over 18 papers with the name of "Oxidative Stress" in the title. He has been Editor-in-Chief of the journal "Archives of Biochemistry and Biophysics" for many years, and is a former Editor-in-Chief of the journal "Free Radical Research". He has clarified our understanding of the causes of chronic developing diseases, and has studied antioxidant factors. In this article, importance of "Oxidative Stress" and our mitochondrial oxidative stress studies; roles of mitochondrial ROS, effects of vitamin E and its homologues in oxidative stress-related diseases, effects of antioxidants in vivo and in vitro, and a mitochondrial superoxide theory for oxidative stress diseases and aging are introduced, and some of our interactions with Helmut are described, congratulating and appreciating his great path.
Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan; Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. Electronic address: hmajima@dent.kagoshima-u.ac.jp.
Hideyuki J
HJ
Majima
Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY 40506, USA; The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia.
Hiroko P
HP
Indo
Radio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
Ikuo
I
Nakanishi
Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan.
Shigeaki
S
Suenaga
Radio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
Ken-Ichiro
K
Matsumoto
Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Hirofumi
H
Matsui
Food Hygiene and Environmental Health Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Sakyo-ku, Kyoto 606-8522, Japan.
Yukiko
Y
Minamiyama
Department of Medical Life Systems, Graduate School of Life and Medical Sciences, Doshishia University, Kyoto 610-0394, Japan.
Hiroshi
H
Ichikawa
Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan.
Hsiu-Chuan
HC
Yen
The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia; Faculty of Medicine, Sydney Medical School, Sydney, NSW 2006, Australia.
Clare L
CL
Hawkins
Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200, Denmark.
Michael J
MJ
Davies
Division of Oxidative Stress Research, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Toshihiko
T
Ozawa
Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY 40506, USA.
Daret K
DK
St Clair
D000375:Aging; D000975:Antioxidants; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014810:Vitamin E / Q000502:physiology
D000975:Antioxidants; D017382:Reactive Oxygen Species; D013481:Superoxides; D014810:Vitamin E
Antioxidants; Mitochondria; Oxidative diseases; Oxidative stress