Chemical composition, antioxidant, antibacterial and cytotoxic effects of Artemisia marschalliana Sprengel extract.
The present study was to investigate the gas chromatography/mass spectrometry (GC/MS), in vitro antioxidant, antibacterial and anticancer activity of the ethanolic extract from aerial parts of Artemisia marschalliana Sprengel against human gastric carcinoma (AGS) and L929 cell lines. Phytochemical analysis of A. marschalliana Sprengel extract showed 22 major components and the most dominant compounds were trans-phytol (29.22%), α-Linolenic acid (13.47%) and n-Hexadecanoic acid (9.28%). In addition, the antioxidant and anticancer activity of A. marschalliana Sprengel extract were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods, respectively. Antibacterial activity against selected pathogenic bacteria was also determined. According to the present obtained results, it seems that this plant has potential uses for pharmaceutical industries and further studies of pharmaceutical importance were suggested to be performed on A. marschalliana Sprengel.
a Faculty of Pharmaceutical Chemistry, Department of Phytochemistry and Essential Oils Technology , Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS) , Tehran , Iran.
Soheil
S
Salehi
b Young Researchers and Elite Club, East Tehran Branch , Islamic Azad University , Tehran , Iran.
Amir
A
Mirzaie
b Young Researchers and Elite Club, East Tehran Branch , Islamic Azad University , Tehran , Iran.
Seyed Ataollah
SA
Sadat Shandiz
c Biotechnology Department, School of Advanced Technologies in Medicine , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Hassan
H
Noorbazargan
d Department of Virology , Pasteur Institute of Iran , Tehran , Iran.
Arian
A
Rahimi
e Department of Biology, East Tehran Branch , Islamic Azad University , Tehran , Iran.
Sima
S
Yarmohammadi
f Department of Biology, Tehran North Branch , Islamic Azad University , Tehran , Iran.
Fatemeh
F
Ashrafi
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D019306:Artemisia / Q000737:chemistry*; D002460:Cell Line; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D010936:Plant Extracts
Artemisia marschalliana Sprengel; GC-MS; cytotoxicity; phytocomponent