Quantification of fatal helium exposure following self-administration.
Helium is nontoxic at standard conditions, plays no biological role, and is found in trace amounts in human blood. Helium can be dangerous if inhaled to excess, since it is a simple tissue hypoxia and so displaces the oxygen needed for normal respiration. This report presents a fatal case of a middle-aged male victim who died from self-administered helium exposure. For the first time, the quantification of the helium levels in gastric and lung air and in blood samples was achieved using gas chromatography-mass spectrometry after airtight sampling. The results of the toxicological investigation showed that death was caused directly by helium exposure. However, based on the pathomorphological changes detected during the forensic autopsy, we suppose that the fatal outcome was the result of the lack of oxygen after inhalation.
Department of Forensic Medicine, Angers University Hospital, Angers cedex 09, F-49933, France. stmalbranque@chu-angers.fr.
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Malbranque
Department of Forensic Medicine, Angers University Hospital, Angers cedex 09, F-49933, France.
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Mauillon
Department of Forensic Medicine, Angers University Hospital, Angers cedex 09, F-49933, France.
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Turcant
Department of Forensic Medicine, Angers University Hospital, Angers cedex 09, F-49933, France.
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Rouge-Maillart
Forensic Toxicology and Chemistry Unit, University Center of Legal Medicine, Lausanne-Geneva, CH-1000, Lausanne 25, Switzerland.
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Mangin
Forensic Toxicology and Chemistry Unit, University Center of Legal Medicine, Lausanne-Geneva, CH-1000, Lausanne 25, Switzerland.
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Varlet
D000280:Administration, Inhalation; D000328:Adult; D001237:Asphyxia / Q000209:etiology / Q000473:pathology*; D053593:Forensic Toxicology / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry; D006371:Helium / Q000032:analysis* / Q000506:poisoning*; D006801:Humans; D008168:Lung / Q000737:chemistry; D008297:Male; D013270:Stomach / Q000737:chemistry; D013405:Suicide; D014132:Trachea / Q000737:chemistry
D006371:Helium
Forensic science; GC-MS; Helium; Hypoxia; Suffocation; Suicide