Ameliorative Effect of Carvacrol on Cisplatin-Induced Reproductive Damage in Male Rats.
Cisplatin (CP) treatment causes the damage in male reproductive system. Carvacrol (CARV) is an antioxidant that is naturally found in some plants. We aimed to investigate the effect of CARV on CP-induced reproductive toxicity in male rats. Eighteen adult male Sprague-Dawley rats were used. The control group (n = 6) was treated orally with physiological saline (PS) daily for 14 days and a single intraperitoneal (IP) PS injection on day 10. The CP group (n = 6) was administered with daily oral PS for 14 days and a single IP injection of 10 mg/kg CP on day 10. The CARV + CP group (n = 6) was treated with daily 75 mg/kg oral CARV for 14 days and a single IP injection of 10 mg/kg CP on day 10. CP treatment caused the damage on some spermatological parameters (motility, live sperm rate, and abnormal sperm rate), increased the oxidative stress, and induced testicular degeneration and apoptosis. However, CARV treatment mitigates CP-induced reproductive toxicity.
Department of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey. emrahaksu@atauni.edu.tr.
Emrah Hicazi
EH
Aksu
Department of Biochemistry, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.
Fatih Mehmet
FM
Kandemir
Department of Pathology, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.
Serdar
S
Altun
Department of Biochemistry, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.
Sefa
S
Küçükler
Department of Pathology, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.
Selim
S
Çomaklı
Department of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.
Ali Doğan
AD
Ömür
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000081007:Cymenes; D005786:Gene Expression Regulation; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D039821:Monoterpenes / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D000081007:Cymenes; D039821:Monoterpenes; D008315:Malondialdehyde; C073316:carvacrol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C505410:Casp3 protein, rat; D053148:Caspase 3; D002945:Cisplatin
Apoptosis; Carvacrol; Cisplatin; Oxidative Stress; Spermiotoxicity