Role of cervical cerclage and prolonged antibiotic therapy with azithromycin in patients with previous perinatal loss amnionitis.
In the group of 35 patients with cerclage, intermediate fetal mortality was reduced from 37.1% to 0 (p < 0.001); late fetal mortality rate from 8.5% to 2.8% (p = 0.606); prematurity from 65.7% to 5.7% (p < 0.001); newborn underweight from 11.4% to 5.7% (p = 0.671); newborns with very low weight from 34.2% to 0 (p < 0.001) and the abortion rate from 8.5% to 0 ( p  < 0.001). In the group of 19 patients without buckling, intermediate fetal mortality was reduced from 26.3% to 10.5% (p = 402); late fetal mortality from 63.1% to 0 (p < 0.001); prematurity 78.9% to 31.5% (p < 0.009); the newborn of low weight from 31.5% to 10.5% (p = 0.234); newborns with very low weight from 68.4% to 15.7% (p < 0.003) and the abortion rate from 36.8 to 0 (p < 0.001). In conclusion, we believe the results of this study demonstrate the effectiveness of therapeutic and prophylactic cervical cerclage associated with prolonged antibiotic therapy.
a German Hospital , Buenos Aires , Argentina.
R
R
Illia
a German Hospital , Buenos Aires , Argentina.
R
R
Leveque
a German Hospital , Buenos Aires , Argentina.
H
H
Mayer
a German Hospital , Buenos Aires , Argentina.
M
M
de Anchorena
a German Hospital , Buenos Aires , Argentina.
M
M
Uranga Imaz
a German Hospital , Buenos Aires , Argentina.
D
D
Habich
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D023802:Cerclage, Cervical; D002821:Chorioamnionitis / Q000209:etiology / Q000517:prevention & control*; D004334:Drug Administration Schedule; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D017963:Azithromycin
Amnionitis; antibiotics; cervical cerclaje; preterm delivery