Micafungin and a case of polymorphic ventricular tachycardia.
OBJECTIVE
Although echinocandins are relatively safe antifungal drugs, cardiovascular toxicity is an emerging adverse event. This report reviews those side effects and describes a case of polymorphic ventricular tachycardia suggestive of torsades de pointes with micafungin.


METHODS
The patient was on micafungin for oesophageal candidiasis due to drug-drug interactions with fluconazole and amiodarone.


CONCLUSIONS
This is the first known case of polymorphic ventricular tachycardia with micafungin as the possible cause. Clinicians should be aware of this potential adverse event and monitor patients receiving concomitant drugs that can prolong QT interval.
Department of Pharmacy, HSHS St. John's Hospital, Springfield, IL, USA.
P J
PJ
Shah
Division of Infectious Diseases, Southern Illinois University School of Medicine, Springfield, IL, USA.
V
V
Sundareshan
Prairie Cardiovascular, Springfield, IL, USA.
B
B
Miller
Department of Pharmacy Practice, School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, IL, USA.
S J
http://orcid.org/0000-0002-6466-9518
SJ
Bergman
amiodarone; antifungal; echinocandin; micafungin; polymorphic; torsades de pointes; ventricular tachycardia