Linking Smokers' Susceptibility to Tuberculosis with Lysosomal Storage Disorders.
Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility of cigarette smokers to tuberculosis.
Institute of Biology, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands. Electronic address: a.h.meijer@biology.leidenuniv.nl.
Annemarie H
AH
Meijer
Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands.
Johannes M
JM
Aerts
D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology*; D006801:Humans; D016464:Lysosomal Storage Diseases / Q000209:etiology* / Q000235:genetics; D008264:Macrophages / Q000276:immunology*; D012907:Smoking / Q000009:adverse effects*; D014376:Tuberculosis / Q000150:complications / Q000209:etiology* / Q000235:genetics; D015027:Zebrafish