Obesity and Aging in Humans and Nonhuman Primates: A Mini-Review.
The prevalence of obesity in the US is increasing exponentially across gender, age and ethnic groups. Obesity and a long-term hypercaloric diet result in what appears to be accelerated aging, often leading to a multi-systemic deterioration known as the metabolic syndrome. Due to their physiological similarity to humans as well as comparable rates of spontaneous obesity and diabetes mellitus, nonhuman primates provide a useful translational model for the human condition. They allow for an in vivo study of disease progression, interaction of comorbidities, and novel interventions. However, defining obesity in aged humans and nonhuman primates is difficult as the physiological changes that occur with aging are not accounted for using our current systems (BMI - body mass index and BCS - body condition score). Nonetheless, nonhuman primate studies have greatly contributed to our understanding of obesity and metabolic dysfunction and should continue to play a large role in translational research. Here, methods for defining obesity and metabolic syndrome in humans and nonhuman primates are described along with the prevalence and effects of these conditions.
Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, Poolesville, Md., USA.
Kelli L
KL
Vaughan
Julie A
JA
Mattison
D000375:Aging / Q000502:physiology*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D009765:Obesity / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D015995:Prevalence; D011323:Primates / Q000502:physiology*