Neonatal Outcome in Pregnancies with Autoimmune Myasthenia Gravis.
BACKGROUND
Acquired autoimmune myasthenia gravis (MG) is an autoimmune process in which antibodies (AB) directed against the acetylcholine nicotinic receptor (AChR) cause weakness and fatigue of striated muscles.


OBJECTIVE
The objective of this study was to determine the range of clinical manifestations in newborns with transient neonatal myasthenia (TNM).


METHODS
62 newborns with mothers who had autoimmune MG were followed by: anthropometric parameters, gestational age, gender, type of delivery completion, Apgar score (AS) in the first and fifth minute, and the emergence of TNM symptoms.


RESULTS
For fourteen consecutive years, from a total of 98,000 infants, 62 (0.06%) were born to mothers with autoimmune MG. Four of them (6.4%) had symptoms of TNM.


CONCLUSIONS
Newborns of mothers with MG manifest clinical features of TNM relative to stage of mother's illness. These newborns need monitoring until the seventh day of life.
a Department of Neonatology , Clinic for Gynecology and Obstetrics, Clinical Center of Serbia , Belgrade , Serbia.
Miljana Z
MZ
Jovandaric
a Department of Neonatology , Clinic for Gynecology and Obstetrics, Clinical Center of Serbia , Belgrade , Serbia.
Dina J
DJ
Despotovic
b Department of Neonatology , School of Medicine, University of Belgrade, University Children's Hospital , Belgrade , Serbia.
Milos M
MM
Jesic
c Department of Endocrinology , School of Medicine, University of Belgrade, University Children's Hospital , Belgrade , Serbia.
Maja D
MD
Jesic
D001034:Apgar Score; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009035:Mothers; D018482:Muscle, Skeletal / Q000473:pathology*; D009157:Myasthenia Gravis / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000473:pathology*
D001323:Autoantibodies
autoimmune myasthenia gravis; newborn; pregnancy