Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics.
The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.
UCLA Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, Los Angeles, CA, USA.
Kalyanam
K
Shivkumar
UCLA Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, Los Angeles, CA, USA.
Olujimi A
OA
Ajijola
Department of Cardiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Inder
I
Anand
UCLA Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, Los Angeles, CA, USA.
J Andrew
JA
Armour
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Peng-Sheng
PS
Chen
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Murray
M
Esler
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Gaetano M
GM
De Ferrari
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Michael C
MC
Fishbein
Division of Cardiology, University of Miami Miller School of Medicine, Miami, FL, USA.
Jeffrey J
JJ
Goldberger
Department of Neurobiology and the Brain Research Institute, University of California, Los Angeles, CA, USA.
Ronald M
RM
Harper
Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, MN, USA.
Michael J
MJ
Joyner
Laureate Institute for Brain Research, Tulsa, OK, USA.
Sahib S
SS
Khalsa
Departments of Anesthesiology and Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Rajesh
R
Kumar
Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA.
Richard
R
Lane
Department of Anesthesia, UCLA, Los Angeles, CA, USA.
Aman
A
Mahajan
Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.|University of Tulsa Oxley College of Health Sciences, Tulsa, OK, USA.
Sunny
S
Po
Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Instituto Auxologico Italiano, c/o Centro Diagnostico e di Ricerrca San Carlo, Milan, Italy.
Peter J
PJ
Schwartz
Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, MN, USA.
Virend K
VK
Somers
Methodist DeBakey Heart and Vascular Center and Methodist Hospital Research Institute, Houston Methodist Hospital, Houston, TX, USA.
Miguel
M
Valderrabano
UCLA Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, Los Angeles, CA, USA.
Marmar
M
Vaseghi
Indiana University School of Medicine, Indianapolis, IN, USA.
Douglas P
DP
Zipes
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology* / Q000628:therapy; D006321:Heart / Q000294:innervation* / Q000502:physiology* / Q000503:physiopathology; D006801:Humans