Flow and compaction properties of hypromellose: new directly compressible versus the established grades.
BACKGROUND
Information about flow and compaction properties of hypromellose (HPMC) polymers is essential for the technologists who are facing challenges regarding poor flow and compaction while developing new controlled release matrix tablets. There is a profound lack of studies in this field and none of the published ones deal with the compaction of the newly introduced HPMC grades specifically designed for direct compression (DC).


OBJECTIVE
The objective behind this study was the evaluation of flow and compaction properties of six different grades of HPMC substitution type 2208 polymers, including two second generation directly compressible grades from Dow Chemical Company (K100LV, K15M, K4M CR, K4M DC, K100M CR and K100M DC).


METHODS
Flow properties were determined using flow time and Carr index. Compaction properties were quantified using "out-of-die" Heckel and modified Walker models as well as tensile strength profile and elastic recovery. We used statistical approach to analyze the results.


CONCLUSIONS
Due to larger, rounder and smoother particles both DC grades showed distinctly better flow properties compared to their non-DC counterparts. Overall, K15M showed the best compaction properties, closely followed by K100LV. K100M grades showed superior compaction properties over K4M grades. The new, second generation DC grades had poorer compaction properties, however, they exhibited better flow properties on the other hand. Considering all compaction results, the Heckel model gave better description of compressibility compared to the Walker model, so it may be preferred in case of studying HPMC polymers and other similar materials.
a Krka, tovarna zdravil, d.d., Novo mesto , Novo mesto , Slovenia ;
Peter
P
Grdešič
a Krka, tovarna zdravil, d.d., Novo mesto , Novo mesto , Slovenia ;|b Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Ljubljana , Ljubljana , Slovenia.
Franc
F
Vrečer
b Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Ljubljana , Ljubljana , Slovenia.
Ilija
I
Ilić
D008747:Methylcellulose / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011312:Pressure; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D013718:Tensile Strength / Q000502:physiology*
D011108:Polymers; D013607:Tablets; D008747:Methylcellulose
Compactibility; HPMC; Heckel; Walker; compressibility; elastic recovery; powder flow; tableting; tensile strength; type 2208