New and Pipeline Drugs for Gout.
Gout is the most common inflammatory arthropathy in the western world. Affecting millions and accounting for lost wages, increased health care costs, and significant disability, it remains a burden for those afflicted, their families, and the health care system. Despite the availability of a number of effective therapies, gout is often inadequately treated, and its impact on the patients overall health and well-being is underestimated by physicians and patients alike. For many decades, controlling acute flares was the priority in the management of gout. More recently, however, a deeper understanding of gout pathophysiology has resulted in a new appreciation that gout impacts the patient with consequences well beyond the episodes of acute inflammatory arthritis. Reflecting the chronic nature of the disease, gout treatment needs to be chronic as well, and aimed at reducing the underlying cause of gout-hyperuricemia-as well as the symptom of acute attacks. Therapy therefore requires both urate lowering and anti-inflammatory strategies. Unfortunately, the most commonly used urate lowering and anti-inflammatory treatments may be problematic in some gout patients, who often have multiple comorbidities that establish relative contraindications. Novel urate lowering therapies, and new medications to treat and prevent acute gouty flares, can not only improve care of the individual; they can also lead to a better discourse for the edification of those who manage and are managed for this underestimated disease. In this paper, we discuss new and pipeline drugs for acute gout, prophylactic anti-inflammatory therapies as well as urate lowering therapies.
Department of Medicine, Duke University School of Medicine, Durham, NC, USA. robert.keenan@duke.edu.|Division of Rheumatology, Duke University Medical Center, 200 Trent Drive DUMC 3544, Durham, NC, USA. robert.keenan@duke.edu.
Robert T
RT
Keenan
Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Naomi
N
Schlesinger
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D003545:Cysteine / Q000031:analogs & derivatives / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods; D006073:Gout / Q000188:drug therapy*; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors; D013864:Thioglycolates / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D001688:Biological Products; D006074:Gout Suppressants; C508585:IL1B protein, human; D053583:Interleukin-1beta; D013864:Thioglycolates; D014230:Triazoles; C000593471:lesinurad; D003545:Cysteine; C026535:bucillamine
Acute gout treatment; Arhalofenate; Gout medications; Lesinurad; Urate lowering therapies; Uricosurics