Dynamic Thiol-Disulphide Status in Polycystic Ovary Syndrome and Its Association with the Pathogenesis of the Disease.
OBJECTIVE
This study aims to examine the differences in plasma thiol-disulphide levels that are related to oxidative stress among obese and nonobese women with polycystic ovary syndrome (PCOS) and their age/body mass index (BMI)-matched healthy controls.


METHODS
The participants were divided into 4 groups based on BMI (nonobese and obese). Serum thiol and disulphide levels were compared among groups.


RESULTS
Serum thiols were found higher in the obese PCOS group than those in the obese control group in the study (thiol: 407.33 ± 46.25 vs. 365.67 ± 67.03 µmol/l, p = 0.014). Disulphide levels were observed to be decreased in the obese PCOS group relative to its control (21.39 ± 1.33 vs. 23.53 ± 8.47 µmol/l, p = 0.021). Serum thiol levels were found to be higher in the nonobese PCOS group compared to nonobese controls (thiol: 434.7 ± 46.92 vs. 422.94 ± 46.61 µmol/l, p = 0.031). Significant differences of disulphide levels between the nonobese PCOS group and the nonobese control group were observed (18.07 ± 1.93 vs. 20.68 ± 3.79 µmol/l, p = 0.027).


CONCLUSIONS
High antioxidant levels in women with PCOS may be related to either mechanisms involving anovulation, multiple follicular development, and apoptosis or to their compensatory system against oxidative load arising from obesity and overweightness.
Department of Obstetrics and Gynecology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Melahat
M
Yildirim
Esengul
E
Turkyilmaz
Salim
S
Neselioglu
Murat
M
Alisik
Ayse Filiz Yavuz
AF
Avsar
D000328:Adult; D000975:Antioxidants / Q000032:analysis; D015992:Body Mass Index; D004220:Disulfides / Q000097:blood*; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*; D011446:Prospective Studies; D013438:Sulfhydryl Compounds / Q000097:blood*; D055815:Young Adult
D000975:Antioxidants; D004220:Disulfides; D013438:Sulfhydryl Compounds