Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of post-traumatic stress disorder.
Post-traumatic stress disorder (PTSD), a disorder that develops following exposure to traumatic experience(s), is frequently associated with agitation, aggressive behavior and psychotic symptoms. Monoamine oxidase (MAO) degrades different biogenic amines and regulates mood, emotions and behavior, and has a role in the pathophysiology of various neuropsychiatric disorders. The aim of the study was to investigate the association between different symptoms occurring in PTSD [PTSD symptom severity assessed by the Clinician Administered PTSD Scale (CAPS), agitation and selected psychotic symptoms assessed by the Positive and Negative Syndrome Scale (PANSS)] and platelet MAO-B activity and/or genetic variants of MAOB rs1799836 and MAOA-uVNTR polymorphisms in 249 Croatian male veterans with PTSD. Our study revealed slightly higher platelet MAO-B activity in veterans with PTSD with more severe PTSD symptoms and in veterans with agitation, and significantly higher platelet MAO-B activity in veterans with more pronounced psychotic symptoms compared to veterans with less pronounced psychotic symptoms. Platelet MAO-B activity was associated with smoking but not with age. Genetic variants of MAOB rs1799836 and MAOA-uVNTR were not associated with agitation and selected psychotic symptoms in veterans with PTSD. A marginally significant association was found between MAOB rs1799836 polymorphism and severity of PTSD symptoms, but it was not confirmed since carriers of G or A allele of MAOB rs1799836 did not differ in their total CAPS scores. These findings suggest an association of platelet MAO-B activity, but a lack of association of MAOB rs1799836 and MAOA-uVNTR, with selected psychotic symptoms in ethnically homogenous veterans with PTSD.
a Division of Molecular Medicine , Rudjer Boskovic Institute , Zagreb , Croatia ;
Dubravka
D
Svob Strac
b Department of Psychopharmacology, Croatian Institute for Brain Research, School of Medicine , University of Zagreb, Zagreb , Croatia ;|c Department of Biological Psychiatry and Psychogeriatry, University Psychiatric Hospital Vrapce , Zagreb , Croatia.
Zrnka
Z
Kovacic Petrovic
a Division of Molecular Medicine , Rudjer Boskovic Institute , Zagreb , Croatia ;
Matea
M
Nikolac Perkovic
a Division of Molecular Medicine , Rudjer Boskovic Institute , Zagreb , Croatia ;
Danica
D
Umolac
a Division of Molecular Medicine , Rudjer Boskovic Institute , Zagreb , Croatia ;
Gordana
G
Nedic Erjavec
a Division of Molecular Medicine , Rudjer Boskovic Institute , Zagreb , Croatia ;
Nela
N
Pivac
D000328:Adult; D000367:Age Factors; D000374:Aggression; D000483:Alleles; D001792:Blood Platelets / Q000378:metabolism*; D004644:Emotions; D056726:Genetic Association Studies; D006801:Humans; D007438:Introns; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000235:genetics; D012720:Severity of Illness Index; D012907:Smoking; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D063189:Symptom Assessment; D014728:Veterans / Q000523:psychology
D008995:Monoamine Oxidase
Agitation; CAPS scores; MAO; PANSS scores; PTSD severity; psychotic symptoms