Nitric oxide-generating l-cysteine-grafted graphene film as a blood-contacting biomaterial.
By using polyethylenimine molecules as the linker, l-cysteine was immobilized onto graphene nanosheets, endowing the biocompatible l-cysteine-functionalized graphene film with the ability for catalytic decomposition of exogenous or endogenous donors to generate nitric oxide, and thus inhibiting the platelet activation and aggregation and reducing platelet adhesion.
School of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450002, China. chenjb@zzu.edu.cn.
Zhen
Z
Du
Ruixia
R
Dou
Mian
M
Zu
Xueying
X
Liu
Wenyan
W
Yin
Yuliang
Y
Zhao
Jingbo
J
Chen
Liang
L
Yan
Zhanjun
Z
Gu
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D049109:Cell Proliferation; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D006108:Graphite / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000097:blood* / Q000737:chemistry* / Q000378:metabolism; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011094:Polyethyleneimine / Q000737:chemistry
D001672:Biocompatible Materials; D009569:Nitric Oxide; D006108:Graphite; D011094:Polyethyleneimine; D003545:Cysteine