[Interactions between dopamine receptor and NMDA/type A γ-aminobutyric acid receptors].
Type A γ-aminobutyric acid receptors (GABAAR) and N-methyl-D-aspartate receptors (NMDAR) are the major inhibitory and excitatory receptors in the central nervous system, respectively. Co-expression of the receptors in the synapse may lead to functional influence between receptors, namely receptor interaction. The interactions between GABAAR and NMDAR can be either positive or negative. However, the mechanisms of interaction between the two receptors remain poorly understood, and potential mechanisms include (1) through a second messenger; (2) by receptors trafficking; (3) by direct interaction; (4) by a third receptor-mediation. Dopamine is the most abundant catecholamine neurotransmitter in the brain, and its receptors, dopamine receptors (DR) can activate multiple signaling pathways. Earlier studies on the interaction between DR and GABAAR/NMDAR have shown some underlying mechanisms, suggesting that DR could mediate the interaction between GABAAR and NMDAR. This paper summarized some recent progresses in the studies of the interaction between DR and NMDAR/GABAAR, providing a further understanding on the interaction between NMDAR and GABAAR mediated by DR.
Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Hui-Ying
HY
Chen
Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Ting-Jia
TJ
Wei
Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jing-Jin
JJ
Weng
Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jiang-Yuan
JY
Qin
Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Xi
X
Huang
Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. ymsu2@126.com.
Ji-Ping
JP
Su
D000818:Animals; D004298:Dopamine; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; D015398:Signal Transduction; D013569:Synapses
D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; D004298:Dopamine