Total body-surface area as a new prognostic variable in mycosis fungoides and Sézary syndrome.
Mycosis fungoides and Sézary syndrome (MF/SS) are the most common forms of primary cutaneous T cell lymphomas. We analyzed the applicability of the cutaneous lymphoma international prognostic index (CLIPi) in MF/SS. We introduced the total body-surface area affected (TBSA) and the type of skin lesions at diagnosis as prognostic variables. The overall survival (OS) at median time of follow up (96 months) was 75.6% (CI 95%, 62.0-98.5%). In the univariate analysis, age>60 years, advanced disease, type of skin lesions and TBSA>50 showed poorer OS (p<0.05). In the multivariate analysis there was a significant increased relative risk of death in those patients>60 years, with advanced disease and TBSA>50% (p<0.05). TBSA identified a group of poor prognosis patients with advanced MF/SS that may benefit from novel systemic therapies.
a Hematology Service, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain ;
Silvana
S
Novelli
b Dermatology Department , Hospital de la Santa Creu i Sant Pau , Barcelona , Spain ;
Pilar
P
García-Muret
c Pathology Department , Hospital de la Santa Creu i Sant Pau , Barcelona , Spain.
Anna
A
Mozos
a Hematology Service, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain ;
Jorge
J
Sierra
a Hematology Service, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain ;
Javier
J
Briones
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001830:Body Surface Area; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000401:mortality; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012751:Sezary Syndrome / Q000175:diagnosis* / Q000401:mortality; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000401:mortality; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D014408:Biomarkers, Tumor
CLIPi; Sézary syndrome; cutaneous T-cell lymphoma; mycosis fungoides; prognosis