A Case Report of Antitubercular Drugs Induced Exanthematous Reaction Complicated by Acute Onset Levofloxacin Induced Toxic Epidermal Necrolysis (TEN).
BACKGROUND
We report a case of 25 years old male patient with antitubercular drugs induced exanthematous reaction and hepatotoxicity that was complicated by levofloxacin induced toxic epidermal necrolysis. The patient was allergic to ciprofloxacin and ofloxacin. Cross reactivity between ciprofloxacin and levofloxacin might be responsible for causing this reaction.


CONCLUSIONS
Issues of cross sensitivity should be kept in mind and the same class of drugs should strictly be avoided to prevent such complications.
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), India.
Khushboo
K
Gajjar
Department of Pharmacology, GMERS Medical College, Junagadh, Gujarat, India.
Hiren
H
Hirapara
Department of Dermatology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001, Gujarat, India.
Chandra Sekhar
CS
Jaiswal
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), India.
Manish
M
Barvaliya
Department of Dermatology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001, Gujarat, India.
Hita
H
Shah
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), India.
Chandrabhanu Rajkishor
CR
Tripathi
D000208:Acute Disease; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D005076:Exanthema / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D064704:Levofloxacin / Q000009:adverse effects*; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000175:diagnosis*
D000995:Antitubercular Agents; D064704:Levofloxacin
Exanthematous reaction; antituberculer drugs; cutaneous adverse reaction; hypersensitivity.; levofloxacin; toxic epidermal necrolysis