PGC-1α, glucose metabolism and type 2 diabetes mellitus.
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolic disturbance. A number of transcription factors and coactivators are involved in this process. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1α is involved in the regulation of T2DM. Therefore, a better understanding of the roles of PGC-1α may shed light on more efficient therapeutic strategies. Here, we review the most recent progress on PGC-1α and discuss its regulatory network in major glucose metabolic tissues such as the liver, skeletal muscle, pancreas and kidney. The significant associations between PGC-1α polymorphisms and T2DM are also discussed in this review.
Department of PathologyHebei Medical University, Shijiazhuang, China Key Laboratory of Kidney Diseases of Hebei ProvinceShijiazhuang, China.
Haijiang
H
Wu
Departments of Oncology & ImmunotherapyHebei General Hospital, Shijiazhuang, China.
Xinna
X
Deng
Department of PathologyHebei Medical University, Shijiazhuang, China Key Laboratory of Kidney Diseases of Hebei ProvinceShijiazhuang, China.
Yonghong
Y
Shi
Mathew Mailing Centre for Translational Transplantation StudiesLawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada Departments of Medicine and PathologyUniversity of Western Ontario, London, Ontario, Canada.
Ye
Y
Su
Department of PathologyHebei Medical University, Shijiazhuang, China Key Laboratory of Kidney Diseases of Hebei ProvinceShijiazhuang, China.
Jinying
J
Wei
Department of PathologyHebei Medical University, Shijiazhuang, China Key Laboratory of Kidney Diseases of Hebei ProvinceShijiazhuang, China duanhuijun999@163.com.
Huijun
H
Duan
D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006526:Hepatitis C / Q000150:complications; D051557:Hepatocyte Nuclear Factor 4 / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D018384:Oxidative Stress; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000378:metabolism; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D005938:Glucocorticoids; C496592:HNF4A protein, human; D051557:Hepatocyte Nuclear Factor 4; D007328:Insulin; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D011960:Receptors, Estrogen; D048051:p38 Mitogen-Activated Protein Kinases; D055372:AMP-Activated Protein Kinases; D037761:Sirtuins; D005947:Glucose
PGC-1α; glucose metabolism; polymorphism; type 2 diabetes mellitus