The relation between glutathione S-Transferase M1 null-genotype and cardiac problems in beta-thalassemia.
This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complications in β-thalassemia.



The studied groups in the present work were divided to three groups (group I: 20 healthy subjects, group II: 56 β-thalassemic patients and group III: 16 β-thalassemic patients with cardiac complications were taken from group II). The measurement of human high sensitive C-reactive protein (hs-CRP) was performed using nephelometry. GSTM1 genotype was detected by Polymerase Chain Reaction (PCR) and cardiac complications were determined by using Echocardiography.



A statistically significant increase in hs-CRP and interleukin-6 (IL-6) levels was found in β-thalassemic patients with cardiac complications compared to normal subjects. Results showed no relation between GSTM1 null genotype frequency neither with β-thalassemia nor with cardiac complications appearance, where the interaction between GSTM1 null genotype in β-thalassemic patients with cardiac complications and healthy subjects were insignificant compared to subjects with GSTM1 non-null genotype.



GSTM1 null genotype frequency has no role in β-thalassemia or cardiac complications appearance.
Department of Immunogenetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt.
Asem Metwally
AM
Abo-Shanab
Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt.
Mohamed Ali
MA
El-Desouky
Department of Immunogenetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt.
Naglaa Mohamed
NM
Kholoussi
Department of Clinical Genetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt.
Ghada Youssef
GY
El-Kamah
Department of Immunogenetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt.
Iman Aly
IA
Helwa
Abdelgawad Ali
AA
Fahmi
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006331:Heart Diseases / Q000235:genetics*; D006801:Humans; D008297:Male; D055815:Young Adult; D017086:beta-Thalassemia / Q000235:genetics*
D005982:Glutathione Transferase