Blue Nevus-Like Metastasis of a Cutaneous Melanoma Identified by Fluorescence In Situ Hybridization.
A blue nevus-like melanoma is a rare melanoma variant arising from or histologically similar to a blue nevus. It can be challenging to distinguish a cellular blue nevus from a blue nevus-like melanoma, particularly in cases of blue nevus-like melanoma lacking a transition from a clearly benign component. We present a case of a 78-year-old man who refused treatment for a previously existing melanoma and subsequently developed a gray nodule near the site of the previous melanoma. After fluorescence in situ hybridization revealed copy number gains in RREB1, this was diagnosed as a blue nevus-like metastatic melanoma. Blue nevus-like metastatic melanoma is most commonly seen near the site of the primary cutaneous melanoma. This entity should be considered in a patient with a history of melanoma and a new blue nevus-like lesion.
*Division of Dermatology, Baylor University Medical Center, Dallas, TX; †Crane Street Dermatology, Menlo Park, CA; ‡ProPath, Dallas, TX; and §Dallas Mohs, Dallas, TX.
Molly
M
Campa
Mahir
M
Patel
Pamela
P
Aubert
Gregory
G
Hosler
Daniel
D
Witheiler
D000368:Aged; D004268:DNA-Binding Proteins / Q000235:genetics; D003937:Diagnosis, Differential; D018628:Gene Dosage; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D018329:Nevus, Blue / Q000175:diagnosis; D012878:Skin Neoplasms; D014157:Transcription Factors / Q000235:genetics; D000096142:Cutaneous Malignant Melanoma
D004268:DNA-Binding Proteins; C101743:RREB1 protein, human; D014157:Transcription Factors