Gamma Radiation Reduced Toxicity of Azoxystrobin Tested on Artemia franciscana.
Fungicide azoxystrobin toxicity was monitored by means of a 96-h biotest with Artemia franciscana nauplius stages after exposure to solutions with concentrations of 0.2, 0.4, 0.6 and 0.8 mg L(-1) irradiated with (60)Co gamma radiation with doses of 1, 2.5, 5 and 10 kGy. The effects of ionization radiation on azoxystrobin toxicity were mainly manifested by a statistically significant reduction of lethality after 72- and 96-h exposure. A maximum reduction of lethality of 72 % was achieved using doses of 1-5 kGy for an azoxystrobin initial concentration of 0.4 mg L(-1) and after 72 h of exposure. At a 96-h exposure, a difference of lethal effects reached up to 70 % for a dose of 10 kGy. The observed effect of gamma ionizing radiation on azoxystrobin toxicity suggest that this approach can be applied as an alternative for a reduction of azoxystrobin residua in food.
Department of Biochemistry and Biophysics, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1946/1, 612 42, Brno, Czech Republic. dvorakp@vfu.cz.
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Dvorak
Department of Biochemistry and Biophysics, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1946/1, 612 42, Brno, Czech Republic.
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Zdarsky
Department of Biology and Genetics, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81, Kosice, Slovak Republic.
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Benova
Department of Toxicology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81, Kosice, Slovak Republic.
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Falis
Department of Biology and Genetics, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81, Kosice, Slovak Republic.
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Tomko
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000633:toxicity*; D001156:Artemia / Q000187:drug effects* / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis; D005516:Food Microbiology; D005720:Gamma Rays; D007928:Lethal Dose 50; D008689:Methacrylates / Q000737:chemistry / Q000633:toxicity*; D011743:Pyrimidines / Q000737:chemistry / Q000633:toxicity*; D011839:Radiation, Ionizing; D000073739:Strobilurins
D000935:Antifungal Agents; D008689:Methacrylates; D011743:Pyrimidines; D000073739:Strobilurins; C087670:azoxystrobin
60Co gamma radiation; Biotest; Fungicide azoxystrobin; Nauplius stages Artemia franciscana