Artemisia Extract Improves Insulin Sensitivity in Women With Gestational Diabetes Mellitus by Up-Regulating Adiponectin.
Gestational diabetes mellitus (GDM) has affected a great number of pregnant women worldwide. Artemisia extracts have been found to exhibit a potent antidiabetic effect in the treatment of type 2 diabetes mellitus. We aimed to examine the effects of Artemisia extract on insulin resistance and lipid profiles in pregnant GDM patients. Patients in their second trimester were randomly assigned to the Artemisia extract group (AE) or to a placebo group (PO). They were instructed to consume either AE or PO daily for a period of 10 weeks. Glucose and insulin profiles and adiponectin level were assessed at baseline (week 0) and after the treatment (week 10). Compared to the PO group, fasting plasma glucose, serum insulin levels, homeostasis model of assessment of insulin resistance (HOMA-IR), and β-cell function (HOMA-B) were significantly reduced in the AE group participants. Moreover, levels of circulating adiponectin were also significantly up-regulated in the AE group, which also positively contributed to improved insulin sensitivity. Daily administration of Artemisia extract improves insulin sensitivity by up-regulating adiponectin in women with gestational diabetes mellitus.
Qingdao Municipal Hospital, Shinan District, Qingdao, Shandong, China.
Xia
X
Sun
Qingdao Municipal Hospital, Shinan District, Qingdao, Shandong, China.
Hong
H
Sun
Qingdao Municipal Hospital, Shinan District, Qingdao, Shandong, China.
Jing
J
Zhang
Qingdao Municipal Hospital, Shinan District, Qingdao, Shandong, China.
Xianghong
X
Ji
D052242:Adiponectin / Q000096:biosynthesis*; D000328:Adult; D019306:Artemisia; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007333:Insulin Resistance / Q000502:physiology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
C499918:ADIPOQ protein, human; D052242:Adiponectin; D007004:Hypoglycemic Agents; D010936:Plant Extracts
Artemisia extract; adiponectin; gestational diabetes mellitus; insulin sensitivity; pregnant