Evidence for cerebellar motor functional reorganization in brain tumor patients: An fMRI study.
Functional reorganization of the motor system following brain damage has been studied extensively in stroke patients, in which not only the cerebrum but also the cerebellum (Cbll) undergoes substantial reorganization. However, the role of Cbll in motor functional reorganization in brain tumor patients remains poorly investigated. Because brain damages in brain tumor patients occur much more slowly than in stroke patients, the neural mechanisms for motor functional reorganization might differ between these two disease conditions. This functional magnetic resonance imaging (fMRI) study investigated whether Cbll constitutes the neural substrates for motor functional reorganization in eighteen supratentorial brain tumor patients who exhibited no clinical signs of paresis. The patients and normal volunteers underwent a unilateral hand movement task. In the patients, the locus of primary sensory motor (SM1) activation during contralesional hand movement was significantly displaced by the tumor, suggesting functional compromise and/or reorganization in the central sulcus region. In addition, their contralesional Cbll activation during contralesional hand movement was substantially increased as compared to normal controls. The finding represents the first conclusive evidence that Cbll is involved in the motor-related functional reorganization in patients with brain tumor.
Department of Neurosurgery, Brain Research Institute, University of Niigata, Japan.
Satoshi
S
Kurabe
Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan.
Kosuke
K
Itoh
Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan.
Tsutomu
T
Nakada
Department of Neurosurgery, Brain Research Institute, University of Niigata, Japan. Electronic address: yfujii@bri.niigata-u.ac.jp.
Yukihiko
Y
Fujii
D000328:Adult; D000368:Aged; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000503:physiopathology*; D016022:Case-Control Studies; D002531:Cerebellum / Q000503:physiopathology*; D005260:Female; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009068:Movement
Brain tumor; Cerebellum; Sensorimotor cortex; fMRI