First synthesis of 22-oxa-chenodeoxycholic acid analogue.
In this study, we report the first synthesis of 22-oxa-chenodeoxycholic acid analogue via androstenedione and progesterone, in 11 and 8 steps with overall yields of 6.4% and 12.7%, respectively. We anticipate this will help to facilitate the development of new drugs.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Yaoling
Y
Wang
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Qiming
Q
Yue
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Yi
Y
Zhao
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Shubing
S
Qiu
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Yao
Y
Peng
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Jue
J
Li
ChengDu Military General Hospital, Chengdu 610083, PR China.
Tao
T
Zhang
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Li
L
Hai
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China. Electronic address: guoli@scu.edu.cn.
Li
L
Guo
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China. Electronic address: wyong@scu.edu.cn.
Yong
Y
Wu
D000735:Androstenedione / Q000737:chemistry; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D011374:Progesterone / Q000737:chemistry
D002635:Chenodeoxycholic Acid; D000735:Androstenedione; D011374:Progesterone
Analogue; Chenodeoxycholic acid; Oxa; Synthesis