Photoactive g-C3 N4 Nanosheets for Light-Induced Suppression of Alzheimer's β-Amyloid Aggregation and Toxicity.
Graphitic carbon nitride (g-C3 N4 ) has a suppressive capability toward Alzheimer's Aβ aggregation under light-illumination. Photoinduced electrons of g-C3 N4 generate reactive oxygen resulting in photooxidation of amyloid peptides that blocks Aβ aggregation. Fe doping of g-C3 N4 frameworks results in enhanced optical properties and even stronger inhibition of Aβ aggregation.
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, South Korea.
You Jung
YJ
Chung
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, South Korea.
Byung Il
BI
Lee
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, South Korea.
Jong Wan
JW
Ko
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, South Korea.
Chan Beum
CB
Park
D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000818:Animals; D006801:Humans; D009570:Nitriles / Q000737:chemistry*; D016716:PC12 Cells; D010446:Peptide Fragments / Q000737:chemistry*; D055668:Photochemical Processes; D066263:Protein Aggregation, Pathological; D051381:Rats; D017382:Reactive Oxygen Species / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D009570:Nitriles; D010446:Peptide Fragments; D017382:Reactive Oxygen Species; C075222:amyloid beta-protein (1-42); C011206:cyanogen
Alzheimer's disease; beta-amyloid; graphitic carbon nitride; nanomaterials; photodynamic therapy