Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin-A Randomized Placebo-Controlled Trial.
Increasing evidence describes a possible interplay between vitamin D insufficiency with increased aldosterone. The authors sought to evaluate the effect of vitamin D supplementation on plasma aldosterone concentration (PAC) in patients with hypertension and 25-hydroxyvitamin D[25(OH)D] insufficiency. The Styrian Vitamin D Hypertension Trial was a single-center, double-blind, placebo-controlled randomized clinical trial conducted from 2011 to 2014. Two hundred patients with arterial hypertension and 25(OH)D levels <30 ng/mL were enrolled. Study participants were randomized to receive either 2800 IU of vitamin D3 or placebo. The present investigation is a post hoc analysis using analysis of covariance adjusting for baseline differences. A total of 188 participants (mean±standard deviation age, 60.1±11.3 years; 47% women; 25(OH)D, 21.2±5.6 ng/mL) completed the trial. Mean differences between baseline and follow-up PAC in the control and intervention arm were +3.3 ng/dL and +0.9 ng/dL, respectively (P=.04). The findings indicate that vitamin D3 supplementation significantly decreases PAC in patients with arterial hypertension and 25(OH)D insufficiency.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.|Swiss Cardiovascular Center Bern, Department of Cardiology, Bern University Hospital, Bern, Switzerland.
Martin R
0000-0002-1761-2914
MR
Grübler
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Martin
M
Gaksch
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Katharina
K
Kienreich
Department of Cardiology, Medical University of Graz, Graz, Austria.
Nicolas
N
Verheyen
Department of Cardiology, Medical University of Graz, Graz, Austria.
Johannes
J
Schmid
Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College, New York, NY.
Bríain W J
BW
Ó Hartaigh
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
Georg
G
Richtig
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Hubert
H
Scharnagl
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Andreas
A
Meinitzer
Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany.
Burkert
B
Pieske
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Astrid
A
Fahrleitner-Pammer
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.|Synlab Academy, Synlab Services GmbH, Mannheim, Germany.
Winfried
W
März
Department of Cardiology, Medical University of Graz, Graz, Austria.|Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria.
Andreas
A
Tomaschitz
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.|Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands.
Stefan
S
Pilz
D000368:Aged; D000450:Aldosterone / Q000097:blood*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage* / Q000494:pharmacology; D014808:Vitamin D Deficiency / Q000178:diet therapy* / Q000378:metabolism
D014807:Vitamin D; D000450:Aldosterone; D012083:Renin