Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive Pulmonary Disease (COPD) Patients.
Antioxidant therapy has a potential to be introduced as therapeutic modality for chronic obstructive pulmonary disease (COPD) patients. This study aimed to determine the effect of antioxidant supplementation [ascorbic acid and N-Acetylcysteine (NAC)] on nutritional and antioxidant status in male COPD patients. A parallel and single blind randomised controlled clinical trial (RCT) was conducted at two medical centers in Kuala Lumpur, Malaysia. Seventy-nine subjects were recruited and randomly divided into four trial arms (i.e., NAC, vitamin C, NAC+vitamin C and control groups) for six mo. The primary outcome was changes in body mass index by estimating power of 90% and significance level of p<0.05. Repeated Measure ANOVA showed that there was a significant interaction effect on BMI (p=0.046) and carbohydrate intake (p=0.030), especially in the NAC group. Plasma glutathione (GSH) increased significantly in all intervention groups, especially in vitamin C (p=0.005). A single supplementation of NAC or vitamin C improved nutritional and antioxidant status of subjects.
Dietetic Programme, Center for Health Care Sciences, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia.
Elham
E
Pirabbasi
Suzana
S
Shahar
Zahara Abdul
ZA
Manaf
Nor Fadilah
NF
Rajab
Roslina Abdul
RA
Manap
D000111:Acetylcysteine / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D015992:Body Mass Index; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D019587:Dietary Supplements; D005978:Glutathione / Q000097:blood; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000187:drug effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D016037:Single-Blind Method; D016896:Treatment Outcome; D014801:Vitamin A / Q000097:blood
D000975:Antioxidants; D004040:Dietary Carbohydrates; D014801:Vitamin A; D005978:Glutathione; D001205:Ascorbic Acid; D000111:Acetylcysteine