Serum levels of brain-derived neurotrophic factor in alcohol-dependent patients receiving high-dose baclofen.
The neurotrophin brain-derived neurotrophic factor (BDNF) has been suggested to be involved in the development and maintenance of addictive and other psychiatric disorders. Also, interactions of γ-aminobutyric acid (GABA)-ergic compounds and BDNF have been reported. The objective of this study was to investigate serum levels of BDNF over time in alcohol-dependent patients receiving individually titrated high-dose treatment (30-270mg/d) with the GABA-B receptor agonist baclofen or placebo for up to 20 weeks. Serum levels of BDNF were measured in patients of the baclofen/placebo group at baseline (t0), 2 weeks after reaching individual high-dose of baclofen/placebo treatment (t1) and after termination of study medication (t2) in comparison to carefully matched healthy controls. No significant differences in serum levels of BDNF between the baclofen and the placebo group or healthy controls were found at t0, t1, or at t2. Based on these findings, it seems unlikely that baclofen exerts a direct effect on serum levels of BDNF in alcohol-dependent patients. Future studies are needed to further explore the mechanism of action of baclofen and its possible relationship to BDNF in alcohol use disorders.
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: olga.geisel@charite.de.
Olga
O
Geisel
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Rainer
R
Hellweg
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Christian A
CA
Müller
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000188:drug therapy*; D001418:Baclofen / Q000008:administration & dosage*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D058786:GABA-B Receptor Agonists / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
D019208:Brain-Derived Neurotrophic Factor; D058786:GABA-B Receptor Agonists; C579455:BDNF protein, human; D001418:Baclofen
alcohol dependence – brain-derived neurotrophic factor – baclofen – GABA-B receptor agonist- RCT