Evaluation of the anti-inflammatory activity of the aqueous and ethanolic extracts of the leaves of Albizzia lebbeck in rats.
Albizzia lebbeck Benth. (Mimosaceae) is a medicinal tree used to treat several inflammatory ailments in the Indian traditional Ayurvedic system of medicine. The aim of the present study was to evaluate the possible anti-inflammatory activity of the aqueous (AE) and ethanolic (EE) extracts of the leaves of A. lebbeck to support the ethnopharmacological claims. The study was carried out using Wistar rats (100-150 g). The AE and EE were prepared using the Soxhlet extraction process. The anti-inflammatory activity of the AE and EE of the leaves of A. lebbeck were studied using carrageenan-induced paw edema and cotton pellet-induced granuloma models. The AE and EE of the leaves of A. lebbeck at doses of 50, 100, and 200 mg/kg p.o. (oral administration) showed a dose-dependent and significant (p < 0.05) inhibition of carrageenan-induced hind paw edema with maximum percentage inhibition (PI) values of 22.34, 30.85, 39.36 and 22.53, 32.98, 42.55, respectively. The AE and EE at doses of 50, 100, 200 mg/kg p.o. significantly (p < 0.05) inhibited granuloma formation with PI values of 19.07, 27.57, 38.55 and 23.93, 32.23, 42.33, respectively. The AE and EE of the leaves of A. lebbeck showed significant (p < 0.05) anti-inflammatory activity.
Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, Inner Ring Road, New Delhi, 110029 Delhi, India.
Girish Gulab
GG
Meshram
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002 Uttar Pradesh, India.
Anil
A
Kumar
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002 Uttar Pradesh, India.
Waseem
W
Rizvi
Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, Inner Ring Road, New Delhi, 110029 Delhi, India.
C D
CD
Tripathi
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002 Uttar Pradesh, India.
R A
RA
Khan
Albizzia lebbeck leaves; Anti-inflammatory; Carrageenan; Cotton pellet; Percentage inhibition