Breast and prostate cancer mortality and industrial pollution.
We investigated whether there might be an excess of breast and prostate cancer mortality among the population residing near Spanish industries, according to different categories of industrial groups. An ecologic study was designed to examine breast and prostate cancer mortality at a municipal level (period 1997-2006). Population exposure to pollution was estimated by means of distance from town of residence to industrial facilities. Using Besag-York-Mollié regression models with Integrated Nested Laplace approximations for Bayesian inference, we assessed the relative risk of dying from these tumors in 2-, 3-, 4-, and 5-km zones around installations, and analyzed the effect of category of industrial group. For all sectors combined, no excess risk was detected. However, excess risk of breast cancer mortality (relative risk, 95% credible interval) was detected near mines (1.10, 1.00-1.21 at 4 km), ceramic industries (1.05, 1.00-1.09 at 5 km), and ship building (1.12, 1.00-1.26 at 5 km), and excess risk of prostate cancer was detected near aquaculture for all distances analyzed (from 2.42, 1.53-3.63 at 2 km to 1.63, 1.07-2.36 at 5 km). Our findings do not support that residing in the vicinity of pollutant industries as a whole (all industrial sectors combined) is a risk factor for breast and prostate cancer mortality. However, isolated statistical associations found in our study with respect to specific industrial groups warrant further investigation.
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: jgarcia@isciii.es.
Javier
J
García-Pérez
Faculty of Statistical Studies, Complutense University of Madrid, Madrid, Spain. Electronic address: natalia_perezabad@hotmail.com.
Natalia
N
Pérez-Abad
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: vicarvajal@isciii.es.
Virginia
V
Lope
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: acastello@isciii.es.
Adela
A
Castelló
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: mpollan@isciii.es.
Marina
M
Pollán
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: mariogonzalez@isciii.es.
Mario
M
González-Sánchez
Faculty of Statistical Studies, Complutense University of Madrid, Madrid, Spain. Electronic address: joseval@estad.ucm.es.
José Luis
JL
Valencia
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: glabente@isciii.es.
Gonzalo
G
López-Abente
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: pfernandezn@isciii.es.
Pablo
P
Fernández-Navarro
D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis*; D001943:Breast Neoplasms / Q000139:chemically induced / Q000401:mortality*; D005260:Female; D062306:Geography, Medical / Q000706:statistics & numerical data*; D006801:Humans; D007220:Industrial Waste / Q000009:adverse effects* / Q000032:analysis*; D008297:Male; D015233:Models, Statistical; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000401:mortality*; D012307:Risk Factors
D007220:Industrial Waste
BYM model; Breast cancer; INLA; Industrial pollution; PRTR register; Prostate cancer