Catching filopodia: Exosomes surf on fast highways to enter cells.
The mechanisms of exosomal uptake and their intracellular itinerary are not understood. In this issue, Heusermann et al. (2016. J Cell. Biol. http://dx.doi.org/10.1083/jcb.201506084) show that exosomes surf filopodia and are endocytosed in a process reminiscent to virus entry. Intraendosomal exosomes travel to the ER and are distributed to lysosomal compartments.
Max-Planck-Institute of Experimental Medicine, 37075 Göttingen, Germany Department for Psychiatry and Psychotherapy, University Medical Center Goettingen, 37075 Göttingen, Germany German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany anja.schneider@dzne.de msimons@gwdg.de.
Anja
A
Schneider
Max-Planck-Institute of Experimental Medicine, 37075 Göttingen, Germany Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany anja.schneider@dzne.de msimons@gwdg.de.
Mikael
M
Simons
D055354:Exosomes; D006801:Humans; D011554:Pseudopodia