The role of JAM-B in cancer and cancer metastasis (Review).
The junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein, which belongs to the immunoglobulin superfamily (IgSF). JAM-B is localized to cell-cell contacts and enriched at cell junctions in epithelial and endothelial cells, as well as on the surface of erythrocytes, leukocytes, and platelets. Recent research in this field has shown that JAM-B plays an important role in numerous cellular processes, such as tight junction assembly, spermatogenesis, regulation of paracellular permeability, leukocytic transmigration, angiogenesis, tumor metastasis and cell proliferation. This study provides a new research direction for the diagnosis and treatment of relevant diseases. In this review, we briefly focus on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer.
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Beijing 100069, P.R. China.
Huishan
H
Zhao
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Beijing 100069, P.R. China.
Hefen
H
Yu
Cardiff-China Medical Research Collaborative, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Tracey A
TA
Martin
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Beijing 100069, P.R. China.
Xu
X
Teng
Cancer Institute of Capital Medical University, Beijing 100069, P.R. China.
Wen G
WG
Jiang
D015815:Cell Adhesion Molecules / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism*; D062765:Junctional Adhesion Molecule B / Q000378:metabolism*; D009369:Neoplasms / Q000473:pathology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D019108:Tight Junctions / Q000378:metabolism*
D015815:Cell Adhesion Molecules; C411887:JAM2 protein, human; D062765:Junctional Adhesion Molecule B