METHODS AND CONSIDERATIONS FOR EXPERIMENTAL EVALUATION OF ANTIEPILEPTIC DRUGS.
Research into epilepsy and development of antiepileptic drugs relies heavily on studies in experimental animals. Though the conventional pentylenetetrazole-induced seizures and electroshock-induced seizures remain the mainstay of any antiepileptic drug screening protocol, considering the diversity of seizure types and underlying pathologies encountered in epilectics, numerous other seizure models have been developed. Some of these experimental models of seizures and considerations governing their selection are reviewed.
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi - 110 029.
Y K
YK
Gupta
J
J
Malhotra
B
B
George
S K
SK
Kulkarni
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
D000927:Anticonvulsants; D010433:Pentylenetetrazole