Transcriptome composition of the preoptic area in mid-age and escitalopram treatment in male mice.
The decrease in serotonergic neurotransmission during aging can increase the risk of neuropsychiatric diseases such as depression in elderly population and decline the reproductive system. Therefore, it is important to understand the age-associated molecular mechanisms of brain aging. In this study, the effect of aging and chronic escitalopram (antidepressant) treatment to admit mice was investigated by comparing transcriptomes in the preoptic area (POA) which is a key nucleus for reproduction. In the mid-aged brain, the immune system-related genes were increased and hormone response-related genes were decreased. In the escitalopram treated brains, transcription-, granule cell proliferation- and vasoconstriction-related genes were increased and olfactory receptors were decreased. Since homeostasis and neuroprotection-related genes were altered in both of mid-age and escitalopram treatment, these genes could be important for serotonin related physiologies in the POA.
Brain Research Institutes, Monash University Malaysia, Bandar Sunway, Selangor 47500, Malaysia. Electronic address: moriya.shogo@monash.edu.
Shogo
S
Moriya
Brain Research Institutes, Monash University Malaysia, Bandar Sunway, Selangor 47500, Malaysia.
Tomoko
T
Soga
Brain Research Institutes, Monash University Malaysia, Bandar Sunway, Selangor 47500, Malaysia.
Dutt Way
DW
Wong
Brain Research Institutes, Monash University Malaysia, Bandar Sunway, Selangor 47500, Malaysia.
Ishwar S
IS
Parhar
D000367:Age Factors; D000818:Animals; D015283:Citalopram / Q000494:pharmacology*; D008297:Male; D008810:Mice, Inbred C57BL; D011301:Preoptic Area / Q000187:drug effects* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D059467:Transcriptome
D015283:Citalopram; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
Aging; DNA microarray; Escitalopram; Reproduction; Serotonin; The preoptic area