Surface arming magnetic nanoparticles with amine N-halamines as recyclable antibacterial agents: Construction and evaluation.
Magnetic recyclable antibacterial nanomaterials, i.e., magnetic amine N-halamine nanoparticles (Fe3O4@SiO2/CTMP NPs), were constructed by arming magnetic silica nanoparticles (Fe3O4@SiO2 NPs) with amine N-halamine (CTMP). Magnetic iron oxide nanoparticles were encapsulated into silica layers followed by anchoring antibacterial amine N-halamines to give magnetic/antibacterial bi-functional agents with core-shell structure. Since the presence of Fe3O4 NPs in core, the products offer super-paramagnetic behavior, which made them separable magnetically after the antibacterial behavior. Their sterilizing effect on bacterial strain was evaluated using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as model bacteria via the plate counting technique, zone of inhibition study, and time kill assay. Antibacterial mechanism study illustrated that the products integrate both the contact mechanism and the release mechanism for attacking bacteria. The significant effect of oxidative chlorine content and concentration of the products on antibiotic action were confirmed. Thanks to the magnetic property, the potential recyclability of the products was achieved. Most significantly, the products retain effective antibacterial action even after five cycles. These findings revealed that the products Fe3O4@SiO2/CTMP NPs have promising applications in the antibacterial fields.
Department of Environmental Engineering, Hohhot Minzu College, Hohhot 010051, People's Republic of China.
Quanfu
Q
Yao
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
Yangyang
Y
Gao
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
Tianyi
T
Gao
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
Yanling
Y
Zhang
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
Chokto
C
Harnoode
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China. Electronic address: dongali@imu.edu.cn.
Alideertu
A
Dong
College of Life and Environmental Science, Minzu University of China, Beijing 100081, People's Republic of China. Electronic address: liuying4300@163.com.
Ying
Y
Liu
Jilin Province Key Laboratory of Carbon Fiber Development and Application, College of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, People's Republic of China. Electronic address: xiaolinghan1981@163.com.
Linghan
L
Xiao
D000588:Amines / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D056951:Photoelectron Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
D000588:Amines; D000900:Anti-Bacterial Agents; D058185:Magnetite Nanoparticles
Amine N-halamine; Antibacterial; Magnetic; Recyclable; Silica