Genetic and environmental modulation of neurodevelopmental disorders: Translational insights from labs to beds.
Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs.
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
Judith R
JR
Homberg
Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Evan J
EJ
Kyzar
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy.
Maria Luisa
ML
Scattoni
Department of Biology, University of Leicester, Leicester, UK.
William H
WH
Norton
Department of Biological and Environmental Sciences, Troy University, Troy, AL, USA.
Julian
J
Pittman
The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Siddharth
S
Gaikwad
The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA; New York University School of Medicine, NY, NY, USA.
Michael
M
Nguyen
The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Manoj K
MK
Poudel
Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Jeremy F P
JF
Ullmann
Department of Psychology, University of South Florida, Tampa, FL, USA; J.A. Haley Veterans Hospital, Research and Development Service, Tampa, FL, USA.
David M
DM
Diamond
The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Aleksandra A
AA
Kaluyeva
School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK.
Matthew O
MO
Parker
Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
Richard E
RE
Brown
Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Graduate Institute of Neural and Cognitive Sciences, China Medical University Hospital, Taichung, Taiwan.
Cai
C
Song
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Moscow Region, Russia.
Raul R
RR
Gainetdinov
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Irving I
II
Gottesman
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia. Electronic address: avkalueff@gmail.com.
Allan V
AV
Kalueff
D026683:Advisory Committees / Q000592:standards; D000818:Animals; D004777:Environment; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D065886:Neurodevelopmental Disorders / Q000235:genetics* / Q000523:psychology / Q000628:therapy*; D057170:Translational Research, Biomedical
Experimental model; Model organism; Neurodevelopmental disorder; Preclinical study; Translational research