The function of mechanical loading on chondrogenesis.
Articular cartilage is exquisitely sensitive to mechanical loading, one of the most important external factors that regulates its development, integrity and long-term maintenance. Cartilage undergoes degradation by its misuse or overuse. In this review, we elaborate on this role and discuss the application of mechanical stress on chondrocytes and mesenchymal stem cells in order to foster chondrogenesis.
Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Zhe
Z
Chen
Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Fuhua
F
Yan
Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China, ly10936@yahoo.com.
Yong
Y
Lu
D000818:Animals; D002358:Cartilage, Articular / Q000254:growth & development / Q000502:physiology; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D013314:Stress, Mechanical; D023822:Tissue Engineering; D016474:Weight-Bearing / Q000502:physiology