Ubiquitin versus misfolding: The minimal requirements for inclusion body formation.
Ubiquitin-containing inclusion bodies are characteristic features of numerous neurodegenerative diseases, but whether ubiquitin plays a functional role in the formation of these protein deposits is unclear. In this issue, Bersuker et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201511024) report that protein misfolding without ubiquitylation is sufficient for translocation into inclusion bodies.
Department of Cell and Molecular Biology, Karolinska Institutet, S-17177 Stockholm, Sweden nico.dantuma@ki.se.
Nico P
NP
Dantuma
Department of Cell and Molecular Biology, Karolinska Institutet, S-17177 Stockholm, Sweden.
Florian A
FA
Salomons
D002479:Inclusion Bodies; D025801:Ubiquitin
D025801:Ubiquitin