The potential role of boswellic acids in cancer prevention and treatment.
Despite the extensive research carried out in the field of cancer therapeutics, cancer is one of the most dreadful diseases in the world with no definitive treatment to date. The key attributes responsible for this are the various limiting factors associated with conventional chemotherapeutics that primarily include adverse side-effects and development of chemoresistance. Hence, there is an utter need to find compounds that are highly safe and efficacious for the prevention and treatment of cancer. Boswellic acid, a group of pentacyclic compounds, seems to be promising enough due to its inherent anti-cancerous properties. Considering this perspective, the present review highlights the established studies related to the anti-cancer potential of boswellic acid against different cancer types. The molecular mechanisms underlying the targets of boswellic acid that are accountable for its potent anti-cancer effect are also discussed. Overall, this review projects the pieces of evidence that reveal the potential of boswellic acid as a suitable candidate that can be appropriately developed and designed into a promising anti-cancer drug.
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, IIT Guwahati, Assam 781039, India.
Nand Kishor
NK
Roy
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, IIT Guwahati, Assam 781039, India.
Anindita
A
Deka
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, IIT Guwahati, Assam 781039, India.
Devivasha
D
Bordoloi
Cancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, 117599 Singapore.
Srishti
S
Mishra
Cancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, 117599 Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600 Singapore.
Alan Prem
AP
Kumar
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600 Singapore. Electronic address: phcgs@nus.edu.sg.
Gautam
G
Sethi
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, IIT Guwahati, Assam 781039, India. Electronic address: kunnumakkara@iitg.ernet.in.
Ajaikumar B
AB
Kunnumakkara
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects; D014315:Triterpenes / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D014315:Triterpenes; C054625:boswellic acid
Boswellic acid; Cancer; Molecular targets; Transcription factors