Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil.
BACKGROUND
Molecular studies about carcinomas of the oral cavity and oropharynx demonstrate the presence of human papilomavirus genome in these tumors, reinforcing the participation of human papilomavirus in oral carcinogenesis.


OBJECTIVE
This study aimed to determine the prevalence of human papilomavirus and genotype distribution of HPV16 and HPV18 in oral cavity and oropharynx carcinomas, as well as their association with clinical characteristics of the tumors.


METHODS
This is a retrospective study, with clinical data collected from 82 patients. Human papilomavirus detection was conducted on specimens of oral cavity and oropharynx carcinomas included in paraffin blocks. Patients were assisted in a cancer reference center, in the central region of Brazil, between 2005 and 2007. Polymerase chain reaction was used for the detection and genotyping of human papilomavirus.


RESULTS
Among the patients evaluated, 78% were male. The average age of the group was about 58 years. Risk factors, such as smoking (78%) and alcohol consumption (70.8%) were recorded for the group. HPV DNA was detected in 21 cases (25.6%; 95% confidence interval 16.9-36.6) of which 33.3% were HPV16 and 14.3% were HPV18. The presence of lymph node metastases and registered deaths were less frequent in human papilomavirus positive tumors, suggesting a better prognosis for these cases; however, the differences between the groups were not statistically significant.


CONCLUSIONS
The results obtained in the present study, with respect to the presence of the high-risk HPV16 and HPV18 genotypes, highlight the importance of human papilomavirus vaccination in the control of oral cavity and oropharynx carcinomas.
Pontifícia Universidade Católica de Goiás (PUC-Goiás), Programa de Mestrado em Genética, Goiânia, GO, Brazil. Electronic address: guilherme.petito@hotmail.com.
Guilherme
G
Petito
Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Megmar Aparecida Dos Santos
MA
Carneiro
Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Sílvia Helena de Rabello
SH
Santos
Pontifícia Universidade Católica de Goiás (PUC-Goiás), Programa de Mestrado em Genética, Goiânia, GO, Brazil.
Antonio Marcio Teodoro Cordeiro
AM
Silva
Associação de Combate ao Câncer em Goiás, Setor de Anatomia Patológica, Laboratório de Oncogenética e Radiobiologia, Goiânia, GO, Brazil.
Rita de Cassia
RC
Alencar
Associação de Combate ao Câncer em Goiás, Setor de Anatomia Patológica, Laboratório de Oncogenética e Radiobiologia, Goiânia, GO, Brazil.
Antonio Paulo
AP
Gontijo
Pontifícia Universidade Católica de Goiás (PUC-Goiás), Programa de Mestrado em Genética, Goiânia, GO, Brazil; Associação de Combate ao Câncer em Goiás, Setor de Anatomia Patológica, Laboratório de Oncogenética e Radiobiologia, Goiânia, GO, Brazil.
Vera Aparecida
VA
Saddi
D001938:Brazil; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D052162:Human papillomavirus 16 / Q000235:genetics*; D052161:Human papillomavirus 18 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000821:virology*; D009959:Oropharyngeal Neoplasms / Q000821:virology*; D030361:Papillomavirus Infections / Q000235:genetics* / Q000821:virology*; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012307:Risk Factors
D004279:DNA, Viral
Epidemiologia; Epidemiology; Head and neck neoplasm; Neoplasia de cabeça e pescoço; Papillomaviridae; Papillomaviridae 16