CYR61 (CCN1) is a metastatic biomarker of gastric cardia adenocarcinoma.
Gastric cardia adenocarcinoma (GCA) is the most aggressive subtype of gastric cancer with a high metastatic rate. In this report, we collected tumor tissue samples from 214 GCA cases and examined expression of CYR61, a target gene product of the Hippo-YAP/TAZ pathway, in the GCA tumors by immunohistochemical (IHC) staining using the tissue microarray assay (TMA). The results have shown that CYR61 is overexpressed in 44% of the GCA tumor samples. Expression of CYR61 is inversely correlated with cumulative survival of GCA patients (p<0.001) and significantly associated only with metastatic pathological categories (with N category, p=0.052; with TNM stage, p=0.001). Furthermore, knockdown of CYR61 in gastric cancer AGS cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis. Thus, our studies have established CYR61 as a metastatic biomarker for prediction of poor prognosis of GCA and provided a potential molecular target for anti-metastatic therapy of GCA.
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Jing
J
Wei
Changzheng Hospital, Shanghai, China.
Guanzhen
G
Yu
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Genbao
G
Shao
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Aiqin
A
Sun
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.|The Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu, China.
Miao
M
Chen
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Wannian
W
Yang
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Qiong
Q
Lin
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002299:Cardia / Q000378:metabolism / Q000473:pathology*; D055515:Cysteine-Rich Protein 61 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014162:Transfection
D014408:Biomarkers, Tumor; C501848:CCN1 protein, human; D055515:Cysteine-Rich Protein 61
CYR61; cell migration; gastric cardia adenocarcinoma; metastasis; prognostic biomarker