Quantifying brain volumes for Multiple Sclerosis patients follow-up in clinical practice - comparison of 1.5 and 3 Tesla magnetic resonance imaging.
There is emerging evidence that brain atrophy is a part of the pathophysiology of Multiple Sclerosis (MS) and correlates with several clinical outcomes of the disease, both physical and cognitive. Consequently, brain atrophy is becoming an important parameter in patients' follow-up. Since in clinical practice both 1.5Tesla (T) and 3T magnetic resonance imaging (MRI) systems are used for MS patients follow-up, questions arise regarding compatibility and a possible need for standardization.



Therefore, in this study 18 MS patients were scanned on the same day on a 1.5T and a 3T scanner. For each scanner, a 3D T1 and a 3D FLAIR were acquired. As no atrophy is expected within 1 day, these datasets can be used to evaluate the median percentage error of the brain volume measurement for gray matter (GM) volume and parenchymal volume (PV) between 1.5T and 3T scanners. The results are obtained with MSmetrix, which is developed especially for use in the MS clinical care path, and compared to Siena (FSL), a widely used software for research purposes.



The MSmetrix median percentage error of the brain volume measurement between a 1.5T and a 3T scanner is 0.52% for GM and 0.35% for PV. For Siena this error equals 2.99%. When data of the same scanner are compared, the error is in the order of 0.06-0.08% for both MSmetrix and Siena.



MSmetrix appears robust on both the 1.5T and 3T systems and the measurement error becomes an order of magnitude higher between scanners with different field strength.
Department of Neurology Hôpital Erasme Université Libre de Bruxelles Anderlecht Belgium.
Andreas P
AP
Lysandropoulos
Department of Radiology Hôpital Erasme Université Libre de Bruxelles Anderlecht Belgium.
Julie
J
Absil
Department of Radiology Hôpital Erasme Université Libre de Bruxelles Anderlecht Belgium.
Thierry
T
Metens
Department of Neurology Hôpital Erasme Université Libre de Bruxelles Anderlecht Belgium.
Nicolas
N
Mavroudakis
Department of Neurology Hôpital Erasme Université Libre de Bruxelles Anderlecht Belgium.
François
F
Guisset
Icometrix Leuven Belgium.
Eline
E
Van Vlierberghe
Icometrix Leuven Belgium.
Dirk
D
Smeets
Department of Radiology Hôpital Erasme Université Libre de Bruxelles Anderlecht Belgium.
Philippe
P
David
Icometrix Leuven Belgium.
Anke
A
Maertens
Icometrix Leuven Belgium.
Wim
W
Van Hecke
D000328:Adult; D001284:Atrophy / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging*; D009929:Organ Size; D011446:Prospective Studies; D012984:Software; D055815:Young Adult
Brain atrophy; MRI; MSmetrix; Multiple Sclerosis; brain volume