The Severe Respiratory Insufficiency Questionnaire for Subjects With COPD With Long-Term Oxygen Therapy.
BACKGROUND
Respiratory insufficiency in COPD may present as hypoxic and/or hypercapnic respiratory failure treated with long-term oxygen therapy (LTOT) and/or noninvasive ventilation (NIV) with LTOT. The Severe Respiratory Insufficiency Questionnaire (SRI) is a tool for the assessment of health-related quality of life (HRQOL) in subjects receiving NIV. However, it remains unclear whether the SRI is also capable of assessing and discriminating HRQOL in subjects receiving LTOT.


METHODS
Stable subjects with COPD receiving LTOT or NIV + LTOT (NIV) were prospectively recruited and completed the SRI, lung function tests, and blood gases. Confirmatory factor analysis for construct validity and internal consistency reliability were calculated.


RESULTS
One hundred fifty-five subjects were included (113 LTOT, 42 NIV). The Cronbach α coefficient of the 7 subscales ranged between 0.69 and 0.89 (LTOT) and between 0.79 and 0.93 (NIV), respectively. In both groups, confirmatory factor analysis revealed a one-factor model for the SRI summary scale; in 5 subscales, one- or 2-factor models could be established. Group differences in the SRI subsets were all P <.05 (except for physical functioning) with higher scores in subjects receiving NIV.


CONCLUSIONS
The SRI showed high reliability and validity in subjects with COPD receiving LTOT. Subjects receiving LTOT had lower SRI scores, indicating a poorer HRQOL compared with subjects with established NIV and LTOT.
Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.
Stephan
S
Walterspacher
Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.
Johanna
J
July
Klinik Schillerhöhe, Center for Pulmonology and Thoracic Surgery, Academic Teaching Hospital of the University of Tübingen, Stuttgart-Gerlingen, Germany.
Martin
M
Kohlhäufl
Ludwig-Maximilians-University of Munich, Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Centre, Munich, Germany.
Peter
P
Rzehak
Department of Pneumology, Kliniken der Stadt Köln gGmbH, Cologne, University of Witten/Herdecke, Witten, Germany.
Wolfram
W
Windisch
D000368:Aged; D001784:Blood Gas Analysis; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000209:etiology; D000860:Hypoxia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D063087:Noninvasive Ventilation; D010102:Oxygen Inhalation Therapy; D011446:Prospective Studies; D011594:Psychometrics; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D011788:Quality of Life; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors
COPD; chronic air flow obstruction; noninvasive ventilation; oxygen inhalation therapy; quality of life; severe respiratory insufficiency questionnaire (SRI)