Lymphedema-associated neutrophilic dermatosis: Two cases of localized Sweet syndrome on the lymphedematous lower limbs.
Neutrophilic dermatosis on the site of lymphedema is a rare condition and considered as a localized and less severe variant of Sweet syndrome. Only 13 cases of this variant have been reported after mastectomy for breast cancer in the English-language published work. However, this condition has never been described on the lower limbs or from other causes of lymphedema. Herein, we report two cases of localized Sweet syndrome on the lymphedematous lower limbs: one occurred after radical hysterectomy, bilateral pelvic lymph node dissection and radiotherapy for cervical cancer; the other developed after radiotherapy for malignant melanoma on the right groin. Based on clinical and histological features, we suggest the name "lymphedema-associated neutrophilic dermatosis" for this underrecognized disease entity.
Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.
Chien-Ho
CH
Chu
Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.
Yu-Ping
YP
Cheng
Department of Pathology and Laboratory Medicine, Cathay General Hospital, Taipei, Taiwan.
Hua-Lin
HL
Kao
Department and Graduate Institute of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Cher-Wei
CW
Liang
Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.
Jung-Yi
JY
Chan
Department of Dermatology, Sijhih Cathay General Hospital, Taipei, Taiwan.
Yu
Y
Yu
D000284:Administration, Oral; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D002097:C-Reactive Protein / Q000032:analysis; D002511:Cephalosporins / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000209:etiology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D007044:Hysterectomy / Q000009:adverse effects* / Q000379:methods; D007263:Infusions, Parenteral; D007964:Leukocytosis / Q000097:blood; D035002:Lower Extremity; D008209:Lymphedema / Q000209:etiology*; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011878:Radiotherapy / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D013921:Thrombocytopenia / Q000097:blood; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005938:Glucocorticoids; D002097:C-Reactive Protein; D011239:Prednisolone; C045693:flomoxef; D006854:Hydrocortisone
corticosteroid; immunocompromised; lymphedema; neutrophilic dermatosis; radiotherapy