Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men.
Depression is associated with coronary heart disease and stroke, but associations with a range of pathologically diverse cardiovascular diseases are not well understood. We examine the risk of 12 cardiovascular diseases according to depression status (history or new onset).



Cohort study of 1,937,360 adult men and women, free from cardiovascular disease at baseline, using linked UK electronic health records between 1997 and 2010. The exposures were new-onset depression (a new GP diagnosis of depression and/or prescription for antidepressants during a one-year baseline), and history of GP-diagnosed depression before baseline. The primary endpoint was initial presentation of 12 cardiovascular diseases after baseline. We used disease-specific Cox proportional hazards models with multiple imputation adjusting for cardiovascular risk factors (age, sex, socioeconomic status, smoking, blood pressure, diabetes, cholesterol).



Over a median [IQR] 6.9 [2.1-10.5] years of follow-up, 18.9% had a history of depression and 94,432 incident cardiovascular events occurred. After adjustment for cardiovascular risk factors, history of depression was associated with: stable angina (Hazard Ratio = 1.38, 95%CI 1.32-1.45), unstable angina (1.70, 1.60-1.82), myocardial infarction (1.21, 1.16-1.27), unheralded coronary death (1.23, 1.14-1.32), heart failure (1.18, 1.13-1.24), cardiac arrest (1.14, 1.03-1.26), transient ischemic attack (1.31, 1.25-1.38), ischemic stroke (1.26, 1.18-1.34), subarachnoid haemorrhage (1.17, 1.01-1.35), intracerebral haemorrhage (1.30, 1.17-1.45), peripheral arterial disease (1.24, 1.18-1.30), and abdominal aortic aneurysm (1.12,1.01-1.24). New onset depression developed in 2.9% of people, among whom 63,761 cardiovascular events occurred. New onset depression was similarly associated with each of the 12 diseases, with no evidence of stronger associations compared to history of depression. The strength of association between depression and these cardiovascular diseases did not differ between women and men.



Depression was prospectively associated with cardiac, cerebrovascular, and peripheral diseases, with no evidence of disease specificity. Further research is needed in understanding the specific pathophysiology of heart and vascular disease triggered by depression in healthy populations.
Department of Infection & Population Health, University College London, London, United Kingdom.
Marina
0000-0001-9927-0358
M
Daskalopoulou
Farr Institute of Health Informatics Research, University College London, London, United Kingdom.
Julie
J
George
Department of Primary Care & Population Health, University College London, London, United Kingdom.
Kate
K
Walters
Division of Psychiatry, University College London, London, United Kingdom.
David P
DP
Osborn
Department of Epidemiology & Public Health, University College London, London, United Kingdom.
G David
GD
Batty
Farr Institute of Health Informatics Research, University College London, London, United Kingdom.
Dimitris
D
Stogiannis
Farr Institute of Health Informatics Research, University College London, London, United Kingdom.
Eleni
E
Rapsomaniki
Farr Institute of Health Informatics Research, University College London, London, United Kingdom.
Mar
M
Pujades-Rodriguez
Farr Institute of Health Informatics Research, University College London, London, United Kingdom.
Spiros
S
Denaxas
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Ruzan
R
Udumyan
Department of Epidemiology & Public Health, University College London, London, United Kingdom.
Mika
M
Kivimaki
Farr Institute of Health Informatics Research, University College London, London, United Kingdom.
Harry
H
Hemingway
D003863:Depression / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000150:complications*; D012307:Risk Factors