D-amino acid-containing supramolecular nanofibers for potential cancer therapeutics.
Nanostructures formed by peptides that self-assemble in water through non-covalent interactions have attracted considerable attention because peptides possess several unique advantages, such as modular design and easiness of synthesis, convenient modification with known functional motifs, good biocompatibility, low immunogenicity and toxicity, inherent biodegradability, and fast responses to a wide range of external stimuli. After about two decades of development, peptide-based supramolecular nanostructures have already shown great potentials in the fields of biomedicine. Among a range of biomedical applications, using such nanostructures for cancer therapy has attracted increased interests since cancer remains the major threat for human health. Comparing with L-peptides, nanostructures containing peptides made of D-amino acid (i.e., D-peptides) bear a unique advantage, biostability (i.e., resistance towards most of endogenous enzymes). The exploration of nanostructures containing D-amino acids, especially their biomedical applications, is still in its infancy. Herein we review the recent progress of D-amino acid-containing supramolecular nanofibers as an emerging class of biomaterials that exhibit unique features for the development of cancer therapeutics. In addition, we give a brief perspective about the challenges and promises in this research direction.
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA.
Huaimin
H
Wang
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA.
Zhaoqianqi
Z
Feng
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA. Electronic address: bxu@brandeis.edu.
Bing
B
Xu
D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use
D000596:Amino Acids; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D010455:Peptides
10-Hydroxycamptothecin (PubChem CID: 97226); 4-Chloro-7-nitrobenzofurazan (PubChem CID: 25043); Cancer therapeutics; D-amino acid; D-peptide; Dapi (PubChem CID: 2954); Multifaceted; Nanofibers; O-Phospho-L-tyrosine (PubChem CID: 30819); Paclitaxel (PubChem CID: 36314); System biology; Taurine (PubChem CID: 1123)