A Primary Investigation on Serum CTX-II Changes in Patients Infected with Brucellosis in Qinghai Plateau, China.
Brucellosis is one of the most widespread zoonotic diseases, with the most frequent complication being osteoarticular changes. The aim of this study was to assess the changes of C-terminal telopeptide of type II collagen (CTX-II) in patients infected with brucellosis. A total of 84 brucellosis patients and 43 volunteers were selected and divided into brucellosis vs. control groups. Serum samples were subjected to serological tests for brucellosis, and CTX-II levels in all samples were measured simultaneously with ELISA. The results showed that serum CTX-II levels in human brucellosis were higher than those of healthy controls, without a statistically significant difference, but serum CTX-II levels in male patients were significantly higher than those of female patients (P<0.05). This finding could indicate the biological changes in the cartilage and bone in human brucellosis.
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Zhi Jun
ZJ
Zhao
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Qiang
Q
Li
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Xin
X
Zhou
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Li
L
Ma
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Li Qing
LQ
Xu
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Pei Zhen
PZ
Yang
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Xian Ya
XY
Meng
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Hui Zhen
HZ
Yu
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Xiao Qing
XQ
Xu
Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
Jian Ying
JY
Cao
D000328:Adult; D002006:Brucellosis / Q000097:blood* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D024043:Collagen Type II / Q000097:blood* / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood* / Q000235:genetics; D012737:Sex Factors
C000590554:C-terminal cross-linking telopeptide of type II collagen, human; D024043:Collagen Type II; D010446:Peptide Fragments