Risk factors for postpartum glucose intolerance in women with gestational diabetes mellitus.
OBJECTIVE
To determine the risk factors for glucose intolerance (GI) during the postpartum period in women with gestational diabetes mellitus (GDM).


METHODS
This prospective cohort study included 72 Japanese women with GDM who underwent 75 g oral glucose tolerance tests (OGTT) at 12 weeks after delivery. These women were divided into the GI group and the normal group based on postpartum OGTT. Risk factors for GI, including levels of blood glucose (BG), area under the curve (AUC) of glucose, AUC insulin, HbA1c, homeostasis model assessment-insulin resistance (HOMA-IR), HOMA-β, insulinogenic index (II) and the oral disposition index (DI) in antepartum OGTT, were analyzed by logistic regression analyses.


RESULTS
Of the 72 women, 60 (83.3%) were normal and 12 (16.7%) had GI. By univariate logistic regression analyses, fasting BG, AUC glucose, HOMA-β, II and oral DI were selected as risk factors for GI. Multivariate logistic regression analysis revealed that the level of II in antepartum OGTT was a significant factor that predicted GI after delivery (odds ratio, 0.008; 95% CI, 0.0001-0.9; p < 0.05).


CONCLUSIONS
II measured by OGTT during pregnancy might be a useful predictor of GI within the early postpartum period in women with GDM.
a Department of Obstetrics and Gynecology , Kobe University Graduate School of Medicine , Kobe , Japan and.
Nobue
N
Kojima
a Department of Obstetrics and Gynecology , Kobe University Graduate School of Medicine , Kobe , Japan and.
Kenji
K
Tanimura
a Department of Obstetrics and Gynecology , Kobe University Graduate School of Medicine , Kobe , Japan and.
Masashi
M
Deguchi
a Department of Obstetrics and Gynecology , Kobe University Graduate School of Medicine , Kobe , Japan and.
Mayumi
M
Morizane
b Division of Diabetes and Endocrinology , Department of Internal Medicine, Kobe University Graduate School of Medicine , Kobe , Japan.
Yushi
Y
Hirota
b Division of Diabetes and Endocrinology , Department of Internal Medicine, Kobe University Graduate School of Medicine , Kobe , Japan.
Wataru
W
Ogawa
a Department of Obstetrics and Gynecology , Kobe University Graduate School of Medicine , Kobe , Japan and.
Hideto
H
Yamada
D000328:Adult; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis*; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D049590:Postpartum Period / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
75 g oral glucose tolerance tests; gestational diabetes mellitus; glucose intolerance; insulinogenic index; postpartum