New streptophenazines from marine Streptomyces sp. 182SMLY.
Six phenazines including three new ones were isolated from the culture of a marine actinomycete Streptomyces sp. 182SMLY. Based on the analyses of NMR, HRESIMS, optical rotation value, and CD data, the structures of these isolated compounds were determined as new phenazines of (-)-streptophenazines M-O and known phenazines of 1-carbomethoxyphenazine and (-)-streptophenazines A and B. (-)-Streptophenazine B showed activity in suppressing the growth of methicillin-resistant Staphylococcus aureus with MIC value of 4.2 μg/mL.
a Ocean College, Zhoushan Campus , Zhejiang University , Zhoushan , China.
Ying
Y
Liang
a Ocean College, Zhoushan Campus , Zhejiang University , Zhoushan , China.
Lu
L
Chen
a Ocean College, Zhoushan Campus , Zhejiang University , Zhoushan , China.
Xuewei
X
Ye
a Ocean College, Zhoushan Campus , Zhejiang University , Zhoushan , China.
Komal
K
Anjum
b College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , China.
Xiao-Yuan
XY
Lian
a Ocean College, Zhoushan Campus , Zhejiang University , Zhoushan , China.
Zhizhen
Z
Zhang
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D010619:Phenazines
(-)-streptophenazine B; (-)-streptophenazines M–O; Streptomyces sp. 182SMLY; antibacterial activity