Utilization and control of ecological interactions in polymicrobial infections and community-based microbial cell factories.
Microbial activities are most often shaped by interactions between co-existing microbes within mixed-species communities. Dissection of the molecular mechanisms of species interactions within communities is a central issue in microbial ecology, and our ability to engineer and control microbial communities depends, to a large extent, on our knowledge of these interactions. This review highlights the recent advances regarding molecular characterization of microbe-microbe interactions that modulate community structure, activity, and stability, and aims to illustrate how these findings have helped us reach an engineering-level understanding of microbial communities in relation to both human health and industrial biotechnology.
Department of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Vinoth
V
Wigneswaran
Department of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Cristina Isabel
CI
Amador
Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Lotte
L
Jelsbak
Department of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Claus
C
Sternberg
Department of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Lars
L
Jelsbak
microbe-microbe interactions; microbial cell factories; microbial communities