Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain.
OBJECTIVE
To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model.


METHODS
Male Sprague-Dawley (250-300 g) rats were anesthetized with ketamine (50 mg/kg, intraperitoneally [i.p.]) and chlorpromazine (25 mg/kg, i.p.). Two bipolar Teflon-coated Ni/Cr wire electrodes (80-M diameter) were placed in the abdominal external oblique muscle for the recording of electromyography. Jugular vein catheter was placed for the administration of drugs. CRD method was applied to evaluate of visceral pain. All drugs (paracetamol, meloxicam, metamizole, and dexketoprofen) administered intravenously.


RESULTS
Paracetamol 200, 400, and 600 mg/kg did not change the visceromotor response (VMR) when compare with the control group. Meloxicam 2 and 4 mg/kg showed no effect but at doses of 6 mg/kg meloxicam significantly ([51.9 ± 6.4%] [P < 0.001]) decreased VMR compared with the control group. Metamizole 200 mg/kg did not change responses but dose of 400 and 600 mg/kg metamizole reduced VMR. Dexketoprofen 2 and 4 mg/kg did not cause a change in VMR but 6 mg/kg dose significantly reduced response compared with the control group ([43.9 ± 3.9%, 36.8 ± 2.8%, 34.8 ± 2.5%, 42.1 ± 4.8%, 40.7 ± 3.5%, 36.4 ± 2.7%, and 26.1 ± 2.2%]; from 10 min to 70 min, respectively, [P < 0.05]).


CONCLUSIONS
Metamizole, dexketoprofen and meloxicam show antinociceptive effect with different duration of action on CRD-induced visceral pain model. This condition can be explained due to different chemical structures and different mechanisms which play a role in modulation of pain.
Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey.
Veysel
V
Baskın
Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey.
S Sırrı
SS
Bilge
Department of Physiology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey.
Ayhan
A
Bozkurt
Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey.
Bahar
B
Akyüz
Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey.
Arzu Erdal
AE
Ağrı
Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey.
Hasan
H
Güzel
Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey.
Fatih
F
İlkaya
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D059265:Visceral Pain / Q000188:drug therapy* / Q000209:etiology
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory; rat; visceral pain