Pristimerin attenuates ovalbumin-induced allergic airway inflammation in mice.
Pristimerin has been shown to possess antiinflammatory activity. However, its potential use for asthma induced by airway inflammation has not yet been studied. First, we established a ovalbumin (OVA)-induced allergic asthma mice model. BALB/c mice were immunized and challenged by OVA. Treatment with pristimerin caused a marked reduction in the levels of OVA-specific IgE, immune cells, and IL-4, IL-5, IL-13 secretion. Histological studies using H&E staining were used to study the alterations in lung tissue. These results were similar to those obtained with dexamethasone treatment. We then investigated which signal transduction mechanisms could be implicated in pristimerin activity by Western blot. The data showed that pristimerin could inhibit MAPKs and NF-κB inflammatory pathways.
a Department of Pharmacology, College of Basic Medical Science , Jilin University , Changchun , People's Republic of China ;
Yingli
Y
Jin
b College of Food Science and Engineering , Jilin University , Changchun , Jilin , People's Republic of China.
Yujia
Y
Wang
b College of Food Science and Engineering , Jilin University , Changchun , Jilin , People's Republic of China.
Danning
D
Zhao
b College of Food Science and Engineering , Jilin University , Changchun , Jilin , People's Republic of China.
Sitong
S
Ma
b College of Food Science and Engineering , Jilin University , Changchun , Jilin , People's Republic of China.
Jing
J
Lu
b College of Food Science and Engineering , Jilin University , Changchun , Jilin , People's Republic of China.
Guan
G
Shuang
D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000276:immunology*; D004195:Disease Models, Animal; D007073:Immunoglobulin E / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000633:toxicity*; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000494:pharmacology*
D016207:Cytokines; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D007073:Immunoglobulin E; D010047:Ovalbumin; C050414:celastrol
Allergic asthma; IgE; MAPK; NF-κB; pristimerin