Synthesis of Novel Imidazo[1,2-a]pyridin-2-amines from Arylamines and Nitriles via Sequential Addition and I2 /KI-Mediated Oxidative Cyclization.
A novel and practical strategy for the construction of imidazo[1,2-a]pyridin-2-amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I2 /KI-mediated oxidative C-N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2-amino substituted imidazo[1,2-a]pyridines and related heterocyclic compounds in an efficient and scalable fashion.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China.
Xianhai
X
Tian
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China.
Lina
L
Song
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China.
Manman
M
Wang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China.
Zhigang
Z
Lv
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China.
Jie
J
Wu
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. wenquan_yu@zzu.edu.cn.
Wenquan
W
Yu
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. changjunbiao@zzu.edu.cn.|Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, P. R. China. changjunbiao@zzu.edu.cn.
Junbiao
J
Chang
C−N bond formation; imidazo[1,2-a]pyridin-2-amine; iodine; oxidative cyclization; sequential synthesis