Suspected acute myocardial infarction in a dystrophin-deficient dog.
Golden retriever muscular dystrophy (GRMD) is a model for the genetically homologous human disease, Duchenne muscular dystrophy (DMD). Unlike the mildly affected mdx mouse, GRMD recapitulates the severe DMD phenotype. In addition to skeletal muscle involvement, DMD boys develop cardiomyopathy. While the cardiomyopathy of DMD is typically slowly progressive, rare early episodes of acute cardiac decompensation, compatible with myocardial infarction, have been described. We report here a 7-month-old GRMD dog with an apparent analogous episode of myocardial infarction. The dog presented with acute signs of cardiac disease, including tachyarrhythmia, supraventricular premature complexes, and femoral pulse deficits. Serum cardiac biomarkers, cardiac-specific troponin I (cTnI) and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), were markedly increased. Echocardiography showed areas of hyperechoic myocardial enhancement, typical of GRMD cardiomyopathy. Left ventricular dyskinesis and elevated cTnI were suggestive of acute myocardial damage/infarction. Over a 3-year period, progression to a severe dilated phenotype was observed.
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States.
Sarah Morar
SM
Schneider
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, NC 27607, United States.
Amanda Erickson
AE
Coleman
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States; Texas A&M Institute for Preclinical Studies, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States.
Lee-Jae
LJ
Guo
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, NC 27607, United States.
Sandra
S
Tou
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, NC 27607, United States.
Bruce W
BW
Keene
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States; Texas A&M Institute for Preclinical Studies, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC 27607, United States; Department of Neurology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC 27607, United States. Electronic address: jkornegay@cvm.tamu.edu.
Joe N
JN
Kornegay
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004283:Dog Diseases / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D009137:Muscular Dystrophy, Animal / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D009206:Myocardium / Q000473:pathology
D015415:Biomarkers
Animal model; Cardiomyopathy; Duchenne muscular dystrophy; Golden retriever muscular dystrophy; Muscular dystrophy; Myocardial infarction