p16 and p53 expression status in head and neck squamous cell carcinoma: a correlation with histological, histoprognostic and clinical parameters.
Different histopathology and prognosis characterise the human papillomavirus (HPV)-related oropharyngeal tumours, but squamous cell carcinomas (SCC) of other localisations have not been exhaustively studied. Tissues from 120 patients with a head and neck SCC were studied for the expression of p16 and p53, and the Brandwein-Gensler (BG) histological risk assessment model. p16 positivity and p53 normal expression were significantly correlated with non-smoking, an earlier T stage and a non-keratinising morphology. The BG risk score was not associated with p16 or p53 expression; p16 expression was associated with a lymphocytic T-cytotoxic response. BG risk score was significantly correlated with overall survival and progression-free survival, while neither p16 nor p53 expression were associated with prognosis. p16 and p53 expression are associated with the histological subtype and the T stage even in non-oropharyngeal-restricted tumours. The BG risk score is not correlated with p16 or p53 and retains its power in non-site-specific SCCs.
Department of Pathology, North Hospital, University Hospital of St-Etienne, France. Electronic address: gakarpath@yahoo.gr.
Georgia
G
Karpathiou
Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
Alessandra
A
Monaya
Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
Fabien
F
Forest
Department of Pneumonology, North Hospital, University Hospital of St-Etienne, France.
Marios
M
Froudarakis
Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
Francois
F
Casteillo
Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
Jean
J
Marc Dumollard
Department of Head and Neck Surgery, North Hospital, University Hospital of St-Etienne, France.
Jean Michel
JM
Prades
Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
Michel
M
Peoc'h
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D018572:Disease-Free Survival; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D018570:Risk Assessment; D012907:Smoking; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D016159:Tumor Suppressor Protein p53
HPV; Immunohistochemistry; histology; prognosis; smoking; squamous cell carcinoma