Citicoline: A Food Beneficial for Patients Suffering from or Threated with Glaucoma.
Oral form of citicoline, a nootropic and neuroprotective drug in use for almost five decades, recently was pronounced a food supplement in both USA and EU. The idea of adding citicoline to topical treatment of primary open angle glaucoma (POAG) aimed at decreasing intraocular pressure (IOP) appeared as a logical consequence of accepting neurodegenerative character of this disease. Experimental data, and also few clinical studies indicate that this substance has potential to counteract some important pathological mechanisms which seem to contribute to POAG initiation and progression, such as excitotoxicity and oxidative stress.
Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences Warsaw, Poland.
Pawel
P
Grieb
Department of Ophthalmology, University of Rostock Rostock, Germany.
Anselm
A
Jünemann
Department of Ophthalmology, Military Institute of Medicine Warsaw, Poland.
Marek
M
Rekas
Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of SciencesWarsaw, Poland; Department of General Ophthalmology, Medical University of LublinLublin, Poland.
Robert
R
Rejdak
citicoline; neuroprotection; primary open angle glaucoma