Diverse roles of HDAC6 in viral infection: Implications for antiviral therapy.
Histone deacetylase 6 (HDAC6), a cytoplasmic enzyme important for many biological processes, has recently emerged as a critical regulator of viral infection. HDAC6 exerts this function either directly, via orchestrating various stages of the viral life cycle, or indirectly via modulating cytokine production by host cells. The broad influence of HDAC6 on viral pathogenesis suggests that this protein may represent an antiviral target. However, the feasibility of targeting HDAC6 and the optimal strategy by which this could be accomplished cannot simply be concluded from individual studies. The primary challenge in developing HDAC6-targeted therapies is to understand how its antiviral effect can be selectively harnessed. As a springboard for future investigations, in this review we recapitulate recent findings on the diverse roles of HDAC6 in viral infection and discuss its alluring potential as a novel antiviral target.
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Linlin
L
Zhang
Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Angela
A
Ogden
Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Ritu
R
Aneja
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China; Institute of Biomedical Sciences, College of Life Sciences, Key Laboratory of Animal Resistance of Shandong Province, Key Laboratory of Molecular and Nano Probes of the Ministry of Education, Shandong Normal University, Jinan 250014, China. Electronic address: junzhou@nankai.edu.cn.
Jun
J
Zhou
D000818:Animals; D006655:Histone Deacetylases / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007372:Interferons / Q000378:metabolism; D014780:Viruses / Q000187:drug effects* / Q000378:metabolism*
D007372:Interferons; D006655:Histone Deacetylases
Antiviral therapy; HDAC6; Viral infection; Viral pathogenesis