Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.|Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Fergus J
FJ
Couch
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Karoline B
KB
Kuchenbaecker
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Kyriaki
K
Michailidou
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Gustavo A
GA
Mendoza-Fandino
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
Silje
S
Nord
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Janna
J
Lilyquist
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Curtis
C
Olswold
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Emily
E
Hallberg
Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, 20133 Padua, Italy.
Simona
S
Agata
Department of Health Studies, The University of Chicago, Chicago, Illinois 60637, USA.|Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois 60637, USA.|Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois 60637, USA.
Habibul
H
Ahsan
Department of Clinical Genetics, Helsinki University Central Hospital, 00029 Helsinki, Finland.
Kristiina
K
Aittomäki
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Christine
C
Ambrosone
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.|Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada M5B 1W8.
Irene L
IL
Andrulis
Department of Epidemiology, University of California Irvine, Irvine, California, 92697, USA.
Hoda
H
Anton-Culver
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Volker
V
Arndt
University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Banu K
BK
Arun
Department of Oncology, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Brita
B
Arver
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy.
Monica
M
Barile
Department of Pathology, Landspitali University Hospital and University of Iceland School of Medicine, 101 Reykjavik, Iceland.
Rosa B
RB
Barkardottir
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Daniel
D
Barrowdale
Institute for Quality and Efficiency in Health Care (IQWiG), 50670 Cologne, Germany.
Lars
L
Beckmann
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Matthias W
MW
Beckmann
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.|Genotyping Unit (CeGen), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.|Biomedical Network on Rare Diseases (CIBERER), 28029 Madrid, Spain.
Javier
J
Benitez
NYU Women's Cancer Program, New York University School of Medicine, New York, New York 10016, USA.
Stephanie V
SV
Blank
Department of Oncology, University of Helsinki and Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Carl
C
Blomqvist
Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Natalia V
NV
Bogdanova
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Stig E
SE
Bojesen
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Manjeet K
MK
Bolla
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy.
Bernardo
B
Bonanni
Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.|University of Tübingen 72074 Tübingen, Germany.
Hiltrud
H
Brauch
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.|Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany.
Hermann
H
Brenner
Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Barbara
B
Burwinkel
Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City Utah 84112, USA.
Saundra S
SS
Buys
Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid 28040, Spain.
Trinidad
T
Caldes
Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, I-56126 Pisa, Italy.
Maria A
MA
Caligo
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Federico
F
Canzian
Australian Breast Cancer Tissue Bank, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales 2145, Australia.
Jane
J
Carpenter
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Jenny
J
Chang-Claude
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
Stephen J
SJ
Chanock
Departments of Pediatrics and Medicine, Columbia University, New York, New York 10032, USA.
Wendy K
WK
Chung
Center for Medical Genetics, Ghent University, 9000 Ghent, Belgium.
Kathleen B M
KB
Claes
Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
Angela
A
Cox
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Simon S
SS
Cross
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Julie M
JM
Cunningham
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Kamila
K
Czene
Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Mary B
MB
Daly
INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, France.
Francesca
F
Damiola
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Hatef
H
Darabi
Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid 28040, Spain.
Miguel
M
de la Hoya
Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands.
Peter
P
Devilee
Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Orland
O
Diez
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Yuan C
YC
Ding
Cancer Bioimmunotherapy Unit, CRO Aviano National Cancer Institute, 33081 Aviano , Italy.
Riccardo
R
Dolcetti
Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA.
Susan M
SM
Domchek
Department of Genetics, University of Pretoria, Pretoria 0007, South Africa.
Cecilia M
CM
Dorfling
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Isabel
I
Dos-Santos-Silva
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada G1V 4G2.
Martine
M
Dumont
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Alison M
AM
Dunning
Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, Hampshire SO16 6YD, UK.
Diana M
DM
Eccles
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala SE-751 85, Sweden.|Department of Clinical Genetics, Lund University Hospital, SE-22185 Lund, Sweden.
Hans
H
Ehrencrona
Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.|Comprehensive Cancer Center -EMN, 91054 Erlangen, Germany.
Arif B
AB
Ekici
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Heather
H
Eliassen
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Steve
S
Ellis
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Peter A
PA
Fasching
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
Jonine
J
Figueroa
Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany.
Dieter
D
Flesch-Janys
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.|Center for Primary Health Care Research, Lund University, SE-221 00 Malmö, Sweden.
Asta
A
Försti
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 15310 Athens, Greece.
Florentia
F
Fostira
Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada H3A 0G4.
William D
WD
Foulkes
University of, Philadelphia, Pennsylvania 19104, USA.
Tara
T
Friebel
Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer 52621, Israel.
Eitan
E
Friedman
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Debra
D
Frost
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Marike
M
Gabrielson
Department of Epidemiology, University of, Chapel Hill, North Carolina 27599-7400, USA.
Marilie D
MD
Gammon
UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California 90095-6900, USA.
Patricia A
PA
Ganz
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Susan M
SM
Gapstur
Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Judy
J
Garber
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Mia M
MM
Gaudet
Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California 90048, USA.
Simon A
SA
Gayther
Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Anne-Marie
AM
Gerdes
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Maya
M
Ghoussaini
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3010, Australia.
Graham G
GG
Giles
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Gord
G
Glendon
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66205, USA.
Andrew K
AK
Godwin
Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 2M1.|Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada H4A 3J1.
Mark S
MS
Goldberg
Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
David E
DE
Goldgar
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Anna
A
González-Neira
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850-9772, USA.
Mark H
MH
Greene
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jacek
J
Gronwald
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 70-115 Villejuif, France.
Pascal
P
Guénel
Department of of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, SW7 2AZ, UK.
Marc
M
Gunter
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Lothar
L
Haeberle
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Christopher A
CA
Haiman
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Ute
U
Hamann
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Thomas V O
TV
Hansen
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Steven
S
Hart
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Sue
S
Healey
Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.|Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Tuomas
T
Heikkinen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Brian E
BE
Henderson
Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California 91010, USA.
Josef
J
Herzog
Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam 1000 BE, The Netherlands.
Frans B L
FB
Hogervorst
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam 3008 AE, The Netherlands.
Antoinette
A
Hollestelle
Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam 3008 AE, The Netherlands.
Maartje J
MJ
Hooning
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
Robert N
RN
Hoover
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
John L
JL
Hopper
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Keith
K
Humphreys
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
David J
DJ
Hunter
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Tomasz
T
Huzarski
N.N. Petrov Institute of Oncology, 197758 St Petersburg, Russia.
Evgeny N
EN
Imyanitov
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.
Claudine
C
Isaacs
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anna
A
Jakubowska
Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia.|Department of Oncology, The University of Melbourne, Melbourne, Victoria 8006, Australia.
Paul
P
James
State Research Institute Centre for Innovative Medicine, LT-08661 Vilnius, Lithuania.
Ramunas
R
Janavicius
Department of Clinical Genetics, Aarhus University Hospital, 8200 Aarhus N, Denmark.
Uffe Birk
UB
Jensen
Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California 94538, USA.
Esther M
EM
John
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK.
Michael
M
Jones
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Maria
M
Kabisch
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Siddhartha
S
Kar
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
Beth Y
BY
Karlan
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Sofia
S
Khan
Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Kay-Tee
KT
Khaw
Department of Health Studies, The University of Chicago, Chicago, Illinois 60637, USA.
Muhammad G
MG
Kibriya
Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Julia A
JA
Knight
Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany.
Yon-Dschun
YD
Ko
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 15310 Athens, Greece.
Irene
I
Konstantopoulou
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Veli-Matti
VM
Kosma
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
Vessela
V
Kristensen
The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong.|Department of Surgery, The University of Hong Kong, Hong Kong, China.
Ava
A
Kwong
Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer 52621, Israel.
Yael
Y
Laitman
Vesalius Research Center, VIB, 3000 Leuven, Belgium.
Diether
D
Lambrechts
Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, 08908 Barcelona, Spain.
Conxi
C
Lazaro
Department of Preventive Medicine, University of Southern California, Los Angeles, California 90032, USA.
Eunjung
E
Lee
Cancer Epidemiology Program, University of Cancer Center, Honolulu, Hawaii 96813, USA.
Loic
L
Le Marchand
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
Jenny
J
Lester
Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Annika
A
Lindblom
Health Sciences Research, Mayo Clinic, Scotsdale, Arizona 85259, USA.
Noralane
N
Lindor
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.|Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Sara
S
Lindstrom
Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
Jianjun
J
Liu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Jirong
J
Long
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan
J
Lubinski
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850-9772, USA.
Phuong L
PL
Mai
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Enes
E
Makalic
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.|Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195, USA.
Kathleen E
KE
Malone
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Arto
A
Mannermaa
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), 20133 Milan, Italy.
Siranoush
S
Manoukian
Department of Oncology, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Sara
S
Margolin
Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Frederik
F
Marme
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam 3008 AE, The Netherlands.
John W M
JW
Martens
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Lesley
L
McGuffog
Department of Gynaecology and Obstetrics, Technical University of Munich, 81675 Munich, Germany.
Alfons
A
Meindl
NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Austin
A
Miller
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3010, Australia.
Roger L
RL
Milne
Department of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA.
Penelope
P
Miron
Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, 20133 Padua, Italy.
Marco
M
Montagna
INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, France.
Sylvie
S
Mazoyer
Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada M5B 1W8.|Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5B 1W8.
Anna M
AM
Mulligan
Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.|Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Taru A
TA
Muranen
Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA.
Katherine L
KL
Nathanson
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Susan L
SL
Neuhausen
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Heli
H
Nevanlinna
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Børge G
BG
Nordestgaard
Invitae Corporation, San Francisco, California 94107, USA.
Robert L
RL
Nussbaum
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Kenneth
K
Offit
Department of Molecular Genetics, National Institute of Oncology, H-1122 Budapest, Hungary.
Edith
E
Olah
Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois 60637, USA.
Olufunmilayo I
OI
Olopade
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Janet E
JE
Olson
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.
Ana
A
Osorio
Department of Preventive Medicine and Biomedical Science, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, 110-799 Seoul, Republic of Korea.
Sue K
SK
Park
Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht 3508 GA, The Netherlands.|MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Petra H
PH
Peeters
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), 20133 Milan, Italy.
Bernard
B
Peissel
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20133 Milan, Italy.
Paolo
P
Peterlongo
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Julian
J
Peto
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Catherine M
CM
Phelan
Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.
Robert
R
Pilarski
Center for Medical Genetics, Ghent University, 9000 Ghent, Belgium.
Bruce
B
Poppe
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, FI-90220 Oulu, Finland.
Katri
K
Pylkäs
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), 20133 Milan, Italy.
Paolo
P
Radice
Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK.
Nazneen
N
Rahman
Department of Clinical Genetics, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Johanna
J
Rantala
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, A 1090 Vienna, Austria.
Christine
C
Rappaport
Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa 34362, Israel.
Gad
G
Rennert
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.
Andrea
A
Richardson
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Mark
M
Robson
International Agency for Research on Cancer, 69008 Lyon, France.
Isabelle
I
Romieu
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Anja
A
Rudolph
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1006 BE, The Netherlands.
Emiel J
EJ
Rutgers
Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain.|CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
Maria-Jose
MJ
Sanchez
Department of Environmental Health Sciences, Columbia University, New York, New York, 10032, USA.
Regina M
RM
Santella
Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, London SE1 9RT, UK.
Elinor J
EJ
Sawyer
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Daniel F
DF
Schmidt
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1006 BE, The Netherlands.
Marjanka K
MK
Schmidt
Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne 50931, Germany.|Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, 50931 Cologne, Germany.|Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Rita K
RK
Schmutzler
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Fredrick
F
Schumacher
Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales 2305, Australia.
Rodney
R
Scott
Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.
Leigha
L
Senter
Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas 66205, USA.
Priyanka
P
Sharma
Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Quebec, Canada G1V 4G2.
Jacques
J
Simard
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, A 1090 Vienna, Austria.
Christian F
CF
Singer
INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, France.|Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon-Centre Léon Bérard, 69373 Lyon, France.
Olga M
OM
Sinilnikova
Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Quebec, Canada G1V 4G2.
Penny
P
Soucy
Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
Melissa
M
Southey
Hannover Medical School, 30625 Hannover, Germany.
Doris
D
Steinemann
Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, SE-58185 Linköping, Sweden.
Marie
M
Stenmark-Askmalm
Institut Curie, Department of Tumour Biology, 75248 Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, 75248 Paris, France.
Dominique
D
Stoppa-Lyonnet
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK.
Anthony
A
Swerdlow
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-2152, USA.
Csilla I
CI
Szabo
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.|Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Rulla
R
Tamimi
Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, Hampshire SO16 6YD, UK.
William
W
Tapper
Department of Genetics, Portuguese Oncology Institute, Porto, 4200-072, Portugal.|Biomedical Sciences Institute (ICBAS), Porto University, 4200-072 Porto, Portugal.
Manuel R
MR
Teixeira
Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500, Malaysia.|University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia.
Soo-Hwang
SH
Teo
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, 10032, USA.
Mary B
MB
Terry
Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark.
Mads
M
Thomassen
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Deborah
D
Thompson
Latvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Laima
L
Tihomirova
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, 43210, USA.
Amanda E
AE
Toland
Department of Surgical Oncology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands.
Robert A E M
RA
Tollenaar
Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
Ian
I
Tomlinson
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 70-115 Villejuif, France.
Thérèse
T
Truong
Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
Helen
H
Tsimiklis
Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, 08908 Barcelona, Spain.
Alex
A
Teulé
Cancer Registry and Histopathology Unit, 'Civic-M.P. Arezzo' Hospital, 97100 ASP Ragusa, Italy.
Rosario
R
Tumino
Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA.
Nadine
N
Tung
Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK.
Clare
C
Turnbull
Cancer Registry of Norway, Institute of Population-Based Cancer Research, N-0304 Oslo, Norway.
Giski
G
Ursin
Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Carolien H M
CH
van Deurzen
Department of Genetics, University of Pretoria, Pretoria 0007, South Africa.
Elizabeth J
EJ
van Rensburg
Institute of Human Genetics, Charite Berlin, 13353 Berlin, Germany.
Raymonda
R
Varon-Mateeva
Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
Zhaoming
Z
Wang
University Hospital Ulm, 89075 Ulm, , Germany.
Shan
S
Wang-Gohrke
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.|Cancer Registry of Norway, Institute of Population-Based Cancer Research, N-0304 Oslo, Norway.|Department of Community Medicine, Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, 9037 Tromsø, Norway.|Genetic Epidemiology Group, Folkhälsan Research Center, 2016 Helsinki, Finland.
Elisabete
E
Weiderpass
Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California 91010, USA.
Jeffrey N
JN
Weitzel
Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California 94305, USA.
Alice
A
Whittemore
Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals, B-3000 Leuven, Belgium.
Hans
H
Wildiers
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, FI-90220 Oulu, Finland.
Robert
R
Winqvist
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Xiaohong R
XR
Yang
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 15310 Athens, Greece.
Drakoulis
D
Yannoukakos
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Song
S
Yao
Servicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain.
M Pilar
MP
Zamora
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Wei
W
Zheng
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Per
P
Hall
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.|Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.|Department of Biostatistics, Harvard School Of Public Health, Boston, Massachusetts 02115, USA.
Peter
P
Kraft
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Celine
C
Vachon
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Susan
S
Slager
Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Georgia
G
Chenevix-Trench
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Paul D P
PD
Pharoah
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Alvaro A N
AA
Monteiro
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850, USA.
Montserrat
M
García-Closas
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Douglas F
DF
Easton
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Antonis C
AC
Antoniou
D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D021983:Cyclophilins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011960:Receptors, Estrogen / Q000235:genetics*; D012307:Risk Factors; D012359:tRNA Methyltransferases
D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D011960:Receptors, Estrogen; C577855:Trmt61B protein, human; D012359:tRNA Methyltransferases; D021983:Cyclophilins; C503209:PPIL3 protein, human