FeSe2-Decorated Bi2Se3Nanosheets Fabricated via Cation Exchange for Chelator-Free64Cu-labeling and Multimodal Image-Guided Photothermal-Radiation Therapy.
Multifunctional theranostic agents have become rather attractive to realize image-guided combination cancer therapy. Herein, we develop a novel method to synthesize Bi2Se3nanosheets decorated with mono-dispersed FeSe2nanoparticles (FeSe2/Bi2Se3) for tetra-modal image-guided combined photothermal & radiation tumor therapy. Interestingly, upon addition of Bi(NO3)3, pre-made FeSe2nanoparticles via cation exchange would be gradually converted into Bi2Se3nanosheets, on which remaining FeSe2nanoparticles are decorated. The yielded FeSe2/Bi2Se3composite-nanostructures were then modified with polyethylene glycol (PEG). Taking advantages of the high r2relaxivity of FeSe2, the X-ray attenuation ability of Bi2Se3, the strong near-infrared (NIR) optical absorbance of the whole nanostructure, as well as the chelate-free radiolabeling of64Cu on FeSe2/Bi2Se3-PEG,in vivomagnetic resonance (MR)/computer tomography (CT)/photoacoustic (PA)/position emission tomography (PET) multimodal imaging was carried out, revealing efficient tumor homing of FeSe2/Bi2Se3-PEG after intravenous injection. Utilizing the intrinsic physical properties of FeSe2/Bi2Se3-PEG,in vivophotothermal & radiation therapy to achieve synergistic tumor destruction was then realized, without causing obvious toxicity to the treated animals. Our work presents a unique method to synthesize composite-nanostructures with highly integrated functionalities, promising not only for nano-biomedicine, but also potentially for other different nanotechnology fields.
Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Liang
L
Cheng
Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Sida
S
Shen
Materials Science Program, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Sixiang
S
Shi
School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu 215123, China.
Yuan
Y
Yi
Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361005, China.
Xiaoyong
X
Wang
Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Guosheng
G
Song
School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu 215123, China.
Kai
K
Yang
Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361005, China.
Gang
G
Liu
Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Todd E
TE
Barnhart
Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Weibo
W
Cai
Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Zhuang
Z
Liu
Cation exchange; Chelator-free radiolabeling; FeSe2/Bi2Se3 nanostructures; Multimodal imaging; Photothermal-radiation therapy treatment