Gastroesophageal Variceal Bleeding as a Complication of Cystic Fibrosis in a 3-Month-Old Patient.
Cystic fibrosis (CF) is a hereditary disease of mucous and sweat glands, which affects the respiratory and gastrointestinal systems. Herein, we describe a 3-month-old girl with a history of recurrent episodes of urinary tract infections that required hospitalization. She was referred to our center at the age of three months, with massive gastroesophageal variceal bleeding. In physical examination, she had clubbing, hepatosplenomegaly, and mild ascites. Laboratory studies revealed high serum levels of liver enzymes and low level of Albumin. As of suspicious to CF, sweat tests were performed twice which confirmed the diagnosis of CF. Gastrointestinal bleeding due to gastroesophageal varices is a rare complication of CF, which could result as a consequence of hepatobiliary involvement of disease. Early diagnosis of CF could prevent severe complications and even death in this group of patients.
Department of Pediatric Gastroenterology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Farzaneh
F
Motamed
Department of Pediatric Gastroenterology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Gholamhossein
G
Fallahi
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Faezeh
F
Ahmadi
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh
F
Bazvand
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Maedeh
M
Ahmadi
Department of Pediatric Gastroenterology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Kambiz
K
Eftekhari
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.AND Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Nima
N
Rezaei
D003550:Cystic Fibrosis / Q000150:complications*; D004932:Esophageal and Gastric Varices / Q000209:etiology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D007223:Infant
Cystic fibrosis; Gastroesophageal varices; Gastrointestinal bleeding; Hepatomegaly