Therapeutic effects of acetylspiramycin and garlicin on cryptosporidiosis among drug users.
Cryptosporidiosis affects humans of all ages, particularly malnourished children and those with compromised immune systems such as HIV/AIDS. This study investigated the therapeutic effects of acetylspiramycin and garlicin on Cryptosporidium infection in institutionalized male drug users receiving rehabilitative treatment. Examination of stool specimens from 903 drug users via modified acid-fast bacilli staining resulted in 172 positive cases. Among them 151 subjects consented to participate in a randomized trial of acetylspiramycin and garlicin in four groups: acetylspiramycin plus garlicin, acetylspiramycin only, garlicin only, and placebo control. The cryptosporidiosis rate was higher in younger subjects with longer drug use history than subjects who are older with shorter history of drug use. After two segments of treatments, 76.2% of the cases achieved negative test results, with the four groups achieving the rates of 92.1%, 76.7%, 72.2%, and 61.8%, respectively (χ(2) = 9.517, P = 0.023). These results indicate clinical potential of garlicin in conjunction with acetylspiramycin in treating cryptosporidiosis.
Department of Epidemiology, School of Public Health, Changsha Medical University, Changsha 410219, China. Electronic address: huangminzhu_2002@163.com.
Min-Zhu
MZ
Huang
The Third Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address: lincoln0221@126.com.
Jin
J
Li
Xiangya School of Medicine, Central South University, Changsha 410078, China. Electronic address: guanlan7@163.com.
Lan
L
Guan
Xiangya School of Medicine, Central South University, Changsha 410078, China. Electronic address: lidengqing@aliyun.com.
Deng-Qing
DQ
Li
The Third Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address: niexinmin19840702@163.com.
Xin-Min
XM
Nie
The Third Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address: aguirong@163.com.
Rong
R
Gui
Department of Epidemiology, School of Public Health, Changsha Medical University, Changsha 410219, China. Electronic address: chen_1987_com@163.com.
Xia
X
Chen
D000328:Adult; D000498:Allyl Compounds / Q000627:therapeutic use*; D003049:Coccidiostats / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy*; D004220:Disulfides / Q000627:therapeutic use*; D055030:Drug Users; D006801:Humans; D008297:Male; D015572:Spiramycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D055815:Young Adult
D000498:Allyl Compounds; D003049:Coccidiostats; D004220:Disulfides; C033163:acetylspiramycin; C028009:diallyl disulfide; D015572:Spiramycin
Acetylspiramycin; Cryptosporidium; Drug user; Garlicin; Randomized controlled trial; Therapeutic effects