One-Step Synthesis of Diverse Pyridine-Containing Heterocycles with 3-Ethoxycyclobutanones at Room Temperature.
An efficient and convenient approach toward a diversity-oriented synthesis of bioactive pyridine-containing fused heterocycles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with various heterocyclic amines, a broad range of heterocyclic compounds were prepared readily at ambient temperature with excellent regioselectivity.
MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.
Yun
Y
Lin
MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.
Xinglin
X
Yang
The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences , Guiyang 550002, China.
Weidong
W
Pan
MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.
Yu
Y
Rao