Neutrophil to Lymphocyte Ratio as a Predictive Marker of Vestibular Schwannoma Growth.
To examine the predictive value of neutrophil to lymphocyte ratio (NLR) for vestibular schwannoma (VS) growth.



Retrospective case-control study.



Tertiary, referral center.



Patients with sporadic VS and available NLR obtained within 1 year from the diagnosis were divided into two groups with growing or non-growing tumor. Patients with known conditions affecting NLR were excluded.



NLR and tumor growth as determined by linear measurements on serial magnetic resonance imaging.



VS growth, demographic factors, and NLR were compared using multi-variant logistic regression and Receiver Operating Characteristic (ROC) curve analysis.



A total of 161 patients fulfilled the inclusion criteria, 79 with growing VS (men:women ratio = 43:36, mean age, 61.8 years) and 82 with non-growing tumors (men:women ratio = 37:45, mean age, 64.9 years). Mean NLR for the group with growing VS was 3.34 (SD [standard deviation] = 1.5) and 2.31 (SD = 0.76) for the group with non-growing VS (p = 0.001; 0.03 when adjusted for all parameters). The optimal cut-off point was NLR = 3.05 with positive predictive value 83.8% and 100% for NLR greater than 5.3. ROC analysis of the adjusted data for age, sex, and side, gave an area under the curve of 0.768, indicating NLR as a good independent predictive marker. Interestingly, the size of tumor was statistically significantly higher for the growing VS group (p = 0.001).



Despite the low specificity of low NLR, our results indicate high NLR as a good predictive marker for VS growth. Confirmation by prospective studies will have a significant impact on patients' management.
*Department of Otolaryngology, Queen Elizabeth University Hospital †School of Medicine, Glasgow University ‡Department of Neurosurgery, Institute of Neurosciences, Queen Elizabeth University Hospital, Glasgow, U.K.
Georgios
G
Kontorinis
John A
JA
Crowther
Stamatina
S
Iliodromiti
William A S
WA
Taylor
Richard
R
Locke
D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology*; D009504:Neutrophils; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D015415:Biomarkers