Because difficulty is not the same for everyone: the impact of complexity in working memory is associated with cannabinoid 1 receptor genetic variation in young adults.
Individual differences in working memory ability are mainly revealed when a demanding challenge is imposed. Here, we have associated cannabinoid 1 (CB1) receptor genetic variation rs2180619 (AA, AG, GG), which is located in a potential CNR1 regulatory sequence, with performance in working memory. Two-hundred and nine Mexican-mestizo healthy young participants (89 women, 120 men, mean age: 23.26 years, SD = 2.85) were challenged to solve a medium (2-back) vs. a high (3-back) difficulty N-back tasks. All subjects responded as expected, performance was better with the medium than the high demand task version, but no differences were found among genotypes while performing each working memory (WM) task. However, the cost of the level of complexity in N-back paradigm was double for GG subjects than for AA subjects. It is noteworthy that an additive-dosage allele relation was found for G allele in terms of cost of level of complexity. These genetic variation results support that the endocannabinoid system, evaluated by rs2180619 polymorphism, is involved in WM ability in humans.
a Gpo. Neurociencias: Lab. Neurogenomica Cognitiva, Coord. Psicobiología y Neurociencias, Fac. Psicologia , Universidad Nacional Autonoma de Mexico (UNAM) , Cd. Mexico, Mexico.|b Gpo. Neurociencias: Lab. Canabinoides, Depto. Fisiologia, Fac. Medicina , UNAM , Cd. Mexico, Mexico.
Alejandra E
AE
Ruiz-Contreras
a Gpo. Neurociencias: Lab. Neurogenomica Cognitiva, Coord. Psicobiología y Neurociencias, Fac. Psicologia , Universidad Nacional Autonoma de Mexico (UNAM) , Cd. Mexico, Mexico.
Talía V
TV
Román-López
a Gpo. Neurociencias: Lab. Neurogenomica Cognitiva, Coord. Psicobiología y Neurociencias, Fac. Psicologia , Universidad Nacional Autonoma de Mexico (UNAM) , Cd. Mexico, Mexico.
Ulises
U
Caballero-Sánchez
a Gpo. Neurociencias: Lab. Neurogenomica Cognitiva, Coord. Psicobiología y Neurociencias, Fac. Psicologia , Universidad Nacional Autonoma de Mexico (UNAM) , Cd. Mexico, Mexico.
Cintia B
CB
Rosas-Escobar
a Gpo. Neurociencias: Lab. Neurogenomica Cognitiva, Coord. Psicobiología y Neurociencias, Fac. Psicologia , Universidad Nacional Autonoma de Mexico (UNAM) , Cd. Mexico, Mexico.
E Ivett
EI
Ortega-Mora
a Gpo. Neurociencias: Lab. Neurogenomica Cognitiva, Coord. Psicobiología y Neurociencias, Fac. Psicologia , Universidad Nacional Autonoma de Mexico (UNAM) , Cd. Mexico, Mexico.
Miguel A
MA
Barrera-Tlapa
c Departamento de Genómica Computacional , Instituto Nacional de Medicina Genómica (INMEGEN) , Cd. Mexico, Mexico.
Sandra
S
Romero-Hidalgo
d Laboratorio de Diagnóstico Genómico , INMEGEN , Cd. Mexico, Mexico.
Karol
K
Carrillo-Sánchez
e Unidad de Secuenciación , INMEGEN , Cd. Mexico, Mexico.
Salvador
S
Hernández-Morales
f Unidad de Vinculación Científica Facultad de Medicina , UNAM, INMEGEN , Cd. Mexico, Mexico.
Felipe
F
Vadillo-Ortega
g Lab. Medicina Genómica, Hospital Regional "Primero de Octubre" , Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE) , Cd. Mexico, Mexico.
Juan Antonio
JA
González-Barrios
b Gpo. Neurociencias: Lab. Canabinoides, Depto. Fisiologia, Fac. Medicina , UNAM , Cd. Mexico, Mexico.
Mónica
M
Méndez-Díaz
b Gpo. Neurociencias: Lab. Canabinoides, Depto. Fisiologia, Fac. Medicina , UNAM , Cd. Mexico, Mexico.
Oscar
O
Prospéro-García
D000328:Adult; D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007206:Individuality; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D055815:Young Adult
D043884:Receptor, Cannabinoid, CB1
CB1 receptor; CNR1; N-back task; individual differences; working memory