Replication timing and transcriptional control: beyond cause and effect-part III.
DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.
Juan Carlos
JC
Rivera-Mulia
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA; Center for Genomics and Personalized Medicine, Florida State University, Tallahassee, FL, USA. Electronic address: gilbert@bio.fsu.edu.
David M
DM
Gilbert
D000818:Animals; D002453:Cell Cycle; D002467:Cell Nucleus / Q000235:genetics; D004261:DNA Replication; D042522:DNA Replication Timing; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D014158:Transcription, Genetic