Osteoanabolic Implant Materials for Orthopedic Treatment.
Osteoporosis is becoming more prevalent due to the aging demographics of many populations. Osteoporotic bone is more prone to fracture than normal bone, and current orthopedic implant materials are not ideal for the osteoporotic cases. A newly developed strontium phosphate (SrPO4 ) coating is reported herein, and applied to Ti-29Nb-13Ta-4.6Zr (wt%), TNTZ, an implant material with a comparative Young's modulus to that of natural bone. The SrPO4 coating is anticipated to modulate the activity of osteoblast (OB) and osteoclast (OC) cells, in order to promote bone formation. TNTZ, a material with excellent biocompatibility and high bioinertness is pretreated in a concentrated alkaline solution under hydrothermal conditions, followed by a hydrothermal coating growth process to achieve complete SrPO4 surface coverage with high bonding strength. Owing to the release of Sr ions from the SrPO4 coating and its unique surface topography, OB cells demonstrate increased proliferation and differentiation, while the cellular responses of OC are suppressed, compared to the control case, i.e., bare TNTZ. This TNTZ implant with a near physiologic Young's modulus and a functional SrPO4 coating provides a new direction in the design and manufacture of implantable devices used in the management of orthopedic conditions in osteoporotic individuals.
Department of Materials Science and Engineering, Monash University, 20 Research Way, Clayton, VIC, 3800, Australia.
Yun-Fei
YF
Ding
The Medical School, The Australian National University, Acton, ACT, 0200, Australia.|The John Curtin School of Medical Research, The Australian National University, Acton, ACT, 0200, Australia.
Rachel W
RW
Li
Department of Biomaterials Science, Institute for Materials Research, Tohoku University, Aoba-ku, Sendai, 980-8577, Japan.
Masaaki
M
Nakai
Department of Materials Science and Engineering, Monash University, 20 Research Way, Clayton, VIC, 3800, Australia.
Trina
T
Majumdar
The Medical School, The Australian National University, Acton, ACT, 0200, Australia.
Dong-Hai
DH
Zhang
Department of Biomaterials Science, Institute for Materials Research, Tohoku University, Aoba-ku, Sendai, 980-8577, Japan.
Mitsuo
M
Niinomi
Department of Materials Science and Engineering, Monash University, 20 Research Way, Clayton, VIC, 3800, Australia.
Nick
N
Birbilis
The Medical School, The Australian National University, Acton, ACT, 0200, Australia.|The John Curtin School of Medical Research, The Australian National University, Acton, ACT, 0200, Australia.
Paul N
PN
Smith
Department of Materials Science and Engineering, Monash University, 20 Research Way, Clayton, VIC, 3800, Australia.
Xiao-Bo
XB
Chen
D000328:Adult; D000497:Alloys / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006801:Humans; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D010710:Phosphates / Q000737:chemistry*; D013324:Strontium / Q000737:chemistry*
D000497:Alloys; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D010710:Phosphates; C052774:strontium phosphate; D013324:Strontium
bone fracture; orthopedic implants; osteoporosis; strontium phosphate; titanium