Coffee intake and risk of pancreatic cancer: an updated meta-analysis of prospective studies.
Inconsistent results on the relationship between coffee consumption and pancreatic cancer risk has been reported in both epidemiological studies and previous meta-analyses. This updated meta-analyses was conducted to assess the association of coffee intake with pancreatic cancer risk. We evaluated the relationship of coffee ingestion and pancreatic cancer risk by performing a meta-analysis of prospective cohort studies and made an explicit document search in the PubMed database before November 2015. We also obtained prospective cohort studies of previous meta-analyses. A random-effects model was used for pooling overall relative risk. Twenty articles of coffee ingestion and pancreatic cancer were contained in our meta-analysis. The summary relative risk (RR) of pancreatic cancer and coffee intake of the highest compared with lowest category was 0.99 (95% CI = 0.81-1.21), with statistically moderate heterogeneity (I2 = 47.9%, P = 0.008). The heterogeneity reduced to I2 = 38.5% after excluding one studies, and the RR was 1.06 (95% CI = 0.94-1.20). The relationships of coffee intake and pancreatic risk did not modified by geographic areas, sex of participants, number of cases, follow-up years, and the number of adjusted confounders. Dose-response analysis indicated that every one-cup increase in coffee consumption was associated with an 1% increase in pancreatic cancer risk. No statistically significant publication biases existed. Coffee consumption may weakly increase the risk of pancreatic cancer.
Institute of Integrated Medicine, Xiangya Hospital, Central South University, Changsha, Hunan Province, China - 18692224642@163.com.
Kechao
K
Nie
Zhihua
Z
Xing
Wei
W
Huang
Weihao
W
Wang
Weiping
W
Liu