Systemic redox imbalance in stable chronic obstructive pulmonary disease.
BACKGROUND
Increased oxidative burden is found in chronic obstructive pulmonary disease (COPD).


OBJECTIVE
To assess the association of ceruloplasmin, albumin, bilirubin, transferrin, thiols and malondialdehyde (MDA) with stable COPD.


METHODS
Oxidative stress markers measured in 106 COPD patients and 45 healthy subjects were evaluated.


RESULTS
Higher ceruloplasmin and MDA, and lower albumin, transferrin and thiols in COPD patients were found. Ceruloplasmin was the strongest single predictor of COPD. The model combining ceruloplasmin, albumin and thiols improved their individual diagnostic performances.


CONCLUSIONS
Diagnostic characteristics of ceruloplasmin, albumin, transferrin, thiols and MDA suggest their potential value as additional tools in disease diagnosis.
a University Department of Chemistry, Medical School University Hospital Centre Sestre Milosrdnice , Zagreb , Croatia.
Lara
L
Milevoj Kopčinović
b Department of Pharmaceutical Botany, Faculty of Pharmacy and Biochemistry , University of Zagreb , Zagreb , Croatia.
Ana-Marija
AM
Domijan
c Department of Medical Biochemistry and Hematology , Faculty of Pharmacy and Biochemistry, University of Zagreb , Zagreb , Croatia.
Ksenija
K
Posavac
c Department of Medical Biochemistry and Hematology , Faculty of Pharmacy and Biochemistry, University of Zagreb , Zagreb , Croatia.
Ivana
I
Čepelak
c Department of Medical Biochemistry and Hematology , Faculty of Pharmacy and Biochemistry, University of Zagreb , Zagreb , Croatia.
Tihana
T
Žanić Grubišić
c Department of Medical Biochemistry and Hematology , Faculty of Pharmacy and Biochemistry, University of Zagreb , Zagreb , Croatia.
Lada
L
Rumora
Growth factors/cytokines/inflammatory mediators; oxidative stress; respiratory disease