Fabrication and characterization of modified nanofibrous poly(L-lactic acid) scaffolds by thermally induced phase separation technique and aminolysis for promoting cyctocompatibility.
Modified nanofibrous Poly(L-lactic acid) (PLLA) scaffolds were fabricated by aminolysis combined with thermally induced phase separation technique using PLLA/1,4-dioxane/urea-NaOH-H2O system at -40 °C freeze temperature. Aminolysis led to the modification of scaffold resulting in enhancement in the bioactivity. The surface of the modified nanofibrous scaffold provided a good environment for attachment and proliferation of MC3T3-E1 subclone 14 cells, exhibiting significant potential for bone tissue regeneration and for promoting cytocompatibility.
a College of Chemistry and Chemical Engineering , Fujian Normal University , Fuzhou , China.
Shunyu
S
Chen
a College of Chemistry and Chemical Engineering , Fujian Normal University , Fuzhou , China.
Zhihang
Z
He
a College of Chemistry and Chemical Engineering , Fujian Normal University , Fuzhou , China.
Guojie
G
Xu
a College of Chemistry and Chemical Engineering , Fujian Normal University , Fuzhou , China.
Xiufeng
X
Xiao
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D004146:Dioxanes / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry*
D001672:Biocompatible Materials; D004146:Dioxanes; D011091:Polyesters; C033616:poly(lactide); C025223:1,4-dioxane
Nanofibrous scaffold; aminolysis; bioactivity; phase separation; polylactic acid