Metal-organic frameworks: mechanisms of antibacterial action and potential applications.
The growing resistance of pathogens to conventional antibiotics has become a public health problem and raises the need to seek new effective solutions. Metal-organic frameworks (MOFs) are porous, hybrid materials comprising metal ions linked by organic binding ligands. The possibility of using a variety of chemical building components in MOFs enables the formation of structures with desired properties. They can act as a reservoir of metal ions, providing their gradual release and resulting in a sustained antibacterial action analogous to that proposed for metal/metal oxide nanoparticles (NPs) but different to that of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications, as illustrated by examples discussed in this review.
Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Medyczna 9, 30-688 Kraków, Poland.
Gabriela
G
Wyszogrodzka
Jagiellonian University, Faculty of Chemistry, Ingardena 3, 30-060 Kraków, Poland.
Bartosz
B
Marszałek
Jagiellonian University, Faculty of Chemistry, Ingardena 3, 30-060 Kraków, Poland.
Barbara
B
Gil
Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Medyczna 9, 30-688 Kraków, Poland. Electronic address: mfdorozy@cyf-kr.edu.pl.
Przemysław
P
Dorożyński
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D000073396:Metal-Organic Frameworks / Q000008:administration & dosage* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D000073396:Metal-Organic Frameworks