Pancreatic panniculitis as a paraneoplastic phenomenon of a pancreatic acinar cell carcinoma.
We present the case of a 59-year-old patient admitted with extreme painful erythematous subcutaneous nodules of the lower extremities in association with arthritis and peripheral eosinophilia. Upon skin biopsy, the diagnosis of pancreatic panniculitis was made. On further investigation, an underlying acinar cell type pancreas carcinoma was revealed. This clinical case does illustrate how a seemingly innocuous skin condition may herald an underlying malignant disease. The presence of pancreatic panniculitis should trigger clinicians to undertake further thorough diagnostic investigation of the pancreas.
a Department of Dermatology , AZ Sint-Jan , Bruges , Belgium.
Charlotte
C
Naeyaert
b Department of Gastroenterology and Hepatology , AZ Sint-Jan , Bruges , Belgium.
Frederik
F
de Clerck
b Department of Gastroenterology and Hepatology , AZ Sint-Jan , Bruges , Belgium.
Vincent
V
De Wilde
D001706:Biopsy; D018267:Carcinoma, Acinar Cell / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging*; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000209:etiology; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000175:diagnosis; D015434:Panniculitis / Q000175:diagnosis / Q000209:etiology*; D010257:Paraneoplastic Syndromes; D014057:Tomography, X-Ray Computed
Acinar cell carcinoma; BRCA2 mutation; Macrolipase; Pancreatic panniculitis; Paraneoplastic syndrome