Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway.
OBJECTIVE
The purpose of this study was to explore the molecular pathway of BSTCR (Bu Shen Tiao Chong recipe) in retrieving diminished ovary reserve (DOR).


METHODS
The DOR model was established through injecting cyclophosphamide and the effect of BSTCR was examined under this background.


RESULTS
BSTCR was shown to restore depleted brain-derived neurotrophic factor (BDNF), CDC2, cyclin B, GSH1, and P38 levels as well as impaired oocyte maturation and the higher apoptosis induced in DOR. BSTCR also enhances the response of oocytes to in vitro fertilization, with higher implantation rate, birth rate, and placenta weight.


CONCLUSIONS
BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway. And this pathway itself is probably through the consequence on several serum hormones such as FSH, E2, Inhibin B, etc.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China. xiatian_tj@163.com.
Tian
T
Xia
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China.
Yu
Y
Fu
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China.
Shuang
S
Li
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China.
Ruihong
R
Ma
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China.
Zhimei
Z
Zhao
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China.
Baojuan
B
Wang
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China.
Chune
C
Chao
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D051379:Mice; D006080:Ovarian Follicle / Q000187:drug effects* / Q000254:growth & development; D065851:Ovarian Reserve / Q000187:drug effects*; D012333:RNA, Messenger
D019208:Brain-Derived Neurotrophic Factor; D004272:DNA, Mitochondrial; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger
BDNF pathway; DOR model; Ovary reserve; Recipe