Ulcer Protective Activity of Jatropha gossypiifolia Linn. in Wistar Rats.
BACKGROUND
Several synthetic drugs are useful in the treatment of peptic ulcer, but almost of these drugs are used in prolonging time, it may cause several adverse reactions. However, the herbal medicines are more potent to the treatment and minimize the side effects.


OBJECTIVE
To evaluate the methanol extract of Jatropha gossypiifolia Linn. (MEJG) for gastro protective activity against Wistar rats.


METHODS
Anti-ulcer potency of MEJG (100 and 200 mg/kg, b.w.) was assessed using aspirin (200 mg/kg, p.o.) plus pylorus ligation ulcer model and the parameters studied were ulcer index (UI), gastric juice volume, pH, total acidity, and total acid output. Same extract was studied by ethanol-induced (80%, 5 mL/kg, intragastrically) ulcer model, and the UI and biochemical parameters were studied.


RESULTS
The oral administration of MEJG (100 and 200 mg/kg) significantly (P < 0.001) attenuated the ulcer score and anti-secretary parameters (such as the volume of gastric content, free acidity, total acidity, and total acid output) in the aspirin plus pylorus ligation rats. The extract also significantly attenuated (P < 0.001) ulcer score in ethanol-induced ulcer model and lipid peroxidation level and significantly increased the level of glutathione peroxides, catalase, and superoxide dismutase activity. The MEJG may possess active constituents such as alkaloids, glycosides, flavonoids, and terpenes, which may play a major role in gastroprotective effect in Wistar rats.


CONCLUSIONS
The present study provides scientific support for the anti-ulcer activities of extracts of JG and also claimed that antioxidant potential of the extracts. However, substantiates the traditional claims for the usage of this drug in the treatment of gastric ulcer.


CONCLUSIONS
The methanolic extract of jatropha gossypiifolia Linn. for gastro protective activity against aspirin plus pyloric ligation and ethanol induced ulcer models was studied in Wistar rats. JG shows significantly attenuated the ulcer score in both models. And also attenuated in anti-secretory parameters in aspirin induced ulcer model. MEJG may possess active constituents such as alkaloids, glycosides, flavonoids and terpenes, which may play a major role in gastroprotective effect in Wistar rats. Abbreviation Used: MEJG: Methanolic extract of jatropha gossypiifolia, mg: Milli gram, kg: Kilogram, b.w.: Body weight, p.o.: Per oral, UI: Ulcer index, pH: Concentration of H+ ion, mL: Milli litre, JG: Jatropha gossypiifolia,USD: United States Dollar, NSAIDs: Non steroidal anti-inflammatory drugs, v/v: Volume by volume, w/v: Weight by volume, SCMC: Sodium carboxy methyl cellulose, g: Gram, h: Hour, °C: Degree centigrade, n: Number, Rpm: Rotation per minute, Min: Minute, N: Normality, NaoH: Sodium hydroxide, mM - Millimole, TBA: Thiobarbituric acid, nmol: Nanomole, nm: Nanometer, GPx: Glutathione peroxidase, GSH: Reduced glutathione, H2O2: Hydrogen peroxide, SOD: Superoxide dismutase,
Analysis of Variance, μmol: Micromole.
Department of Pharmacology, CL Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamil Nadu, India.
Arumugam Ramamoorthy
AR
Vijayakumar
Department of Pharmacology, CL Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamil Nadu, India.
Epison Prabu
EP
Daniel
Department of Pharmacology, Captain Srinivasa Murti Drug Research Institute for Ayurveda and Siddha Drug Development, CCRAS, Ministry of AYUSH, Government of India, Arumbakkam, Chennai, Tamil Nadu, India.
Raju
R
Ilavarasan
CL Baid Metha Foundation for Pharmaceutical Education and Research, Thoraipakkam, Chennai, Tamil Nadu, India.
S
S
Venkataraman
Department of Pharmacy Practice, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai, Tamil Nadu, India.
S
S
Vijayakumar
Antioxidant enzymes; anti-ulcer; aspirin; ethanol; jatropha gossypiifolia; ranitidine; wistar rats