Cortical abnormalities in Parkinson's disease patients and relationship to depression: A surface-based morphometry study.
Depression is a common occurrence in patients with Parkinson's disease (PD). Brain deficits may be the underlying cause of depression in PD. In the present study, we investigated whether morphometric alterations contribute to depression in PD. Seventeen depressed PD patients, 17 non-depressed PD patients and 45 normal controls were enrolled in the study. All subjects went through neurological and psychiatric clinical assessments. T1 weighted magnetic resonance imaging and surface-based morphometric analyses were performed to examine morphometric abnormalities in PD patients and their relationship to depression. We found that compared with normal controls, PD patients exhibited significantly decreased cortical thickness in the left precentral gyrus and the right postcentral gyrus extending to the middle frontal gyrus. Compared with non-depressed PD patients, depressed patients showed significantly increased cortical areas in the orbitofrontal regions and insula, which may imply white matter atrophy in these areas. The results of orbitofrontal and insula white matter atrophy are consistent with our previous finding that white matter integrity and functional connectivity are damaged in these regions in depressed PD patients, confirming their contribution to depression in PD.
Department of Radiology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Peiyu
P
Huang
Department of Neurology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yuting
Y
Lou
Department of Radiology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Min
M
Xuan
Department of Radiology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Quanquan
Q
Gu
Department of Radiology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaojun
X
Guan
Department of Radiology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaojun
X
Xu
Department of Neurology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Binjiang Hospital, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhe
Z
Song
Department of Neurology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wei
W
Luo
Department of Radiology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: zhangminming@zju.edu.cn.
Minming
M
Zhang
D000368:Aged; D001284:Atrophy / Q000473:pathology; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000473:pathology; D003863:Depression / Q000000981:diagnostic imaging* / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000523:psychology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000473:pathology; D066127:White Matter / Q000000981:diagnostic imaging* / Q000473:pathology
Cortical area; Cortical thickness; Depression; Morphometry; Parkinson's disease