Glucagon action in the brain.
In recent years, novel discoveries have reshaped our understanding of the biology of brain glucagon in the regulation of peripheral homeostasis. Here we compare and contrast brain glucagon action in feeding vs glucose regulation and depict the physiological relevance of brain glucagon by reviewing their actions in two key regions of the central nervous system: the mediobasal hypothalamus and the dorsal vagal complex. These novel findings pave the way to future therapeutic strategies aimed at enhancing brain glucagon action for the treatment of diabetes and obesity. This review summarises a presentation given at the 'Novel data on glucagon' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Young Lee and colleagues, DOI: 10.1007/s00125-016-3965-9 ), and by Russell Miller and Morris Birnbaum, DOI: 10.1007/s00125-016-3955-y ) and an overview by the Session Chair, Isabel Valverde (DOI: 10.1007/s00125-016-3946-z ).
Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, M5G 1L7, Canada.|Department of Physiology, University of Toronto, Toronto, ON, Canada.
Mona A
MA
Abraham
Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, M5G 1L7, Canada. tony.lam@uhnres.utoronto.ca.|Department of Physiology, University of Toronto, Toronto, ON, Canada. tony.lam@uhnres.utoronto.ca.|Department of Medicine, University of Toronto, Toronto, ON, Canada. tony.lam@uhnres.utoronto.ca.|Banting and Best Diabetes Centre, University of Toronto, Toronto, ON, Canada. tony.lam@uhnres.utoronto.ca.|MaRS Centre, 101 College Street, Toronto Medical Discovery Tower, 10th floor-Room 705, Toronto, ON, M5G 1L7, Canada. tony.lam@uhnres.utoronto.ca.
Tony K T
TKT
Lam
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism
D005934:Glucagon
Brain; Dorsal vagal complex; Glucagon action; Glucose and energy homeostasis; Hypothalamus; Protein-feeding, Review