No association between donor age and recipient outcomes: transfusion of plasma in patients undergoing coronary artery bypass grafting surgery.
Recent animal studies suggest that transfusion of plasma from young donors reverses age-related neurologic and cardiac changes in older recipients. Associations between age of blood product donors and corresponding outcomes in recipients have not been studied in humans. Therefore, our primary objective was to examine this relationship between donor age and recipient outcomes among patients that received plasma during and after coronary artery bypass grafting (CABG) surgery.



This retrospective cohort included patients undergoing CABG surgery who received plasma during or after surgery. All plasma units transfused were evenly divided into tertiles based on the plasma donor age (17-37, 38-50, and 51-86 years), and CABG patients receiving all perioperative plasma within a single donor tertile were studied. Patient demographics and outcomes including mortality, length of stay (LOS), and acute kidney injury (AKI) were measured.



Overall, 1306 patients (24% of 5339) received American Red Cross plasma perioperatively, with a median dose of 2 units. In a multivariate model of 1-year mortality, transfusion of a greater number of plasma units (p = 0.0007) and EuroSCORE (p < 0.0001) were significantly associated with patient mortality while donor age was not. There was no difference in mortality between patients receiving plasma from donors in the youngest, middle, or oldest age tertile (10.2 and 8.1% vs. 7.8%, respectively, p = 0.76). Other outcomes, including rates of AKI or LOS, were also independent of plasma donor age.



We did not observe an association between donor age and recipient outcomes among patients who received plasma perioperatively while undergoing CABG surgery.
Department of Anesthesiology, Durham, North Carolina.
Nicole R
NR
Guinn
Department of Anesthesiology, Durham, North Carolina.
Nathan H
NH
Waldron
Department of Anesthesiology, Durham, North Carolina.
Mary L
ML
Cooter
American Red Cross, Carolinas Region, Durham, North Carolina.
Corinne L
CL
Goldberg
Department of Anesthesiology, Durham, North Carolina.
Miklos D
MD
Kertai
Department of Anesthesiology, Durham, North Carolina.|Durham VA Medical Center, Durham, North Carolina.
Karthik
K
Raghunathan
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Nicholas
N
Bandarenko
Durham VA Medical Center, Durham, North Carolina.|Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Maureane
M
Hoffman
Department of Anesthesiology, Durham, North Carolina.
Elliott
E
Bennett-Guerrero
D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016913:Blood Component Transfusion / Q000379:methods / Q000401:mortality / Q000592:standards*; D001782:Blood Donors; D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000401:mortality; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D010949:Plasma; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult