The potential impacts of formyl peptide receptor 1 in inflammatory diseases.
Neutrophils play a critical role in acute and chronic inflammatory diseases. N-formyl peptides, which originate from bacterial peptides or mitochondrial proteins bind with a high binding affinity to formyl peptide receptor 1 (FPR1). N-formyl peptide-FPR1 is involved in the pathogenesis of sterile and infectious inflammatory processes and causes phagocytosis of pathogens or injured cells by neutrophils. Excessive activation of neutrophils by binding of N-formyl peptides is associated with tissue injury requiring drugs that block FPR1-dependent signaling. Here, we review the roles of FPR1 as a critical regulator of inflammatory processes and its involvement in pathological conditions.
Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, Chang Gung University; Department of Anesthesiology, Taipei Veterans General Hospital; National Yang-Ming University, Taiwan.
Shun-Chin
SC
Yang
Graduate Institute of Natural Products, Chang Gugy; Department of Anesthesiology, Chang Gung Memorial Hospital, Taiwanng University; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technolo, 886-3-2118506.
Tsong-Long
TL
Hwang
D002634:Chemotaxis, Leukocyte; D007249:Inflammation / Q000276:immunology*; D018375:Neutrophil Activation; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D044042:Receptors, Formyl Peptide / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
C469986:FPR1 protein, human; D044042:Receptors, Formyl Peptide