MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma.
Aim of the present review is to summarize the current knowledge about the potential relationship between miRNAs and hepatitis B virus (HBV)-hepatitis C virus (HCV) related liver diseases. A systematic computer-based search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine miRNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma (HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: "HBV", "HCV", "hepatocellular carcinoma", "microRNAs", "miRNAs", "diagnosis", "prognosis", "therapy", "treatment". Some serum/plasma miRNAs, including miR-21, miR-122, mi-125a/b, miR-199a/b, miR-221, miR-222, miR-223, miR-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of miRNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of miRNAs for HCC early detection and prognosis.
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Sirio
S
Fiorino
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Maria Letizia
ML
Bacchi-Reggiani
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Michela
M
Visani
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Giorgia
G
Acquaviva
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Adele
A
Fornelli
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Michele
M
Masetti
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Andrea
A
Tura
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Fabio
F
Grizzi
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Matteo
M
Zanello
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Laura
L
Mastrangelo
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Raffaele
R
Lombardi
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Luca
L
Di Tommaso
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Arrigo
A
Bondi
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Sergio
S
Sabbatani
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Andrea
A
Domanico
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Carlo
C
Fabbri
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Paolo
P
Leandri
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Annalisa
A
Pession
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Elio
E
Jovine
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina C, Ospedale Maggiore, 40133 Bologna, Italy.
Dario
D
de Biase
D014408:Biomarkers, Tumor / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D055088:Early Detection of Cancer; D006509:Hepatitis B / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics*; D025202:Molecular Diagnostic Techniques; D011237:Predictive Value of Tests; D011379:Prognosis
D014408:Biomarkers, Tumor; D035683:MicroRNAs
Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinomas; Liver diseases; MicroRNAs; Review