Caffeine and caffeinated beverage consumption and fecundability in a preconception cohort.
Caffeine is an adenosine receptor antagonist that may influence fertility by affecting ovulation, menstrual characteristics, or sperm quality. We studied the association between female and male preconception caffeine intake and fecundability in a North American prospective cohort study of 2135 pregnancy planners. Frequency of caffeinated beverage intake was self-reported at baseline. Outcome data were updated every 8 weeks until reported pregnancy; censoring occurred at 12 months. Adjusted fecundability ratios (FR) and 95% confidence intervals (CI) were estimated using proportional probabilities regression. Total caffeine intake among males, but not females, was associated with fecundability (FR for ≥300 vs. <100mg/day caffeine among males=0.72, 95% CI=0.54-0.96), although the association was not monotonic. With respect to individual beverages, caffeinated tea intake was associated with slight reductions in fecundability among females, and caffeinated soda and energy drink intake were associated with reduced fecundability among males.
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118 USA. Electronic address: akw23@bu.edu.
Amelia K
AK
Wesselink
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118 USA; Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA, 02215 USA.
Lauren A
LA
Wise
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118 USA; RTI International, P.O. Box 12194, Research Triangle Park, NC, 27709 USA.
Kenneth J
KJ
Rothman
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118 USA.
Kristen A
KA
Hahn
Department of Clinical Epidemiology, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus, Denmark.
Ellen M
EM
Mikkelsen
Department of Obstetrics & Gynecology, Boston University Medical Center, 85 East Concord Street, Boston, MA, 02118 USA.
Shruthi
S
Mahalingaiah
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118 USA.
Elizabeth E
EE
Hatch
D000328:Adult; D001628:Beverages; D002110:Caffeine / Q000494:pharmacology*; D002170:Canada / Q000453:epidemiology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D014481:United States / Q000453:epidemiology
D002110:Caffeine
Caffeine; Fertility; Preconception cohort; Soda; Time-to-pregnancy