Soluble Vascular Endothelial Cadherin as a New Biomarker of Irradiation in Highly Irradiated Baboons with Bone Marrow Protection.
Vascular endothelial cadherin is the main component of adherens junctions enabling cohesion of the endothelial monolayer in vessels. The extracellular part of vascular endothelial cadherin (VE-cadherin) can be cleaved, releasing soluble fragments in blood (sVE-cadherin). In some diseases with endothelial dysfunction, a correlation between increased blood sVE-cadherin levels and disease state has been proposed. Irradiation is known to induce endothelial damage, but new serum biomarkers are needed to evaluate endothelial damage after irradiation. Here, the authors investigated whether sVE-cadherin may be an interesting biomarker of irradiation in highly irradiated baboons with bone marrow protection. sVE-cadherin was detected in the plasma of young as well as old baboons. Plasma sVE-cadherin levels significantly decrease a few days after irradiation but recover in the late time after irradiation. Kinetic analysis of plasma sVE-cadherin levels suggests a correlation with white blood cell counts in both the acute phase of irradiation and during hematopoietic recovery, suggesting that plasma sVE-cadherin levels may be partly linked to the disappearance and recovery of white blood cells. Interestingly, after hematopoietic recovery was completed, sVE-cadherin levels were found to exceed control values, suggesting that plasma sVE-cadherin may represent a new biomarker of endothelial damage or neovascularization in the late time after irradiation.
*Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France; †Institut National de la Santé et de la Recherche Médicale, U1036, Grenoble, France; Commissariat à l'Energie Atomique et aux Energies Alternatives, Institute of Life Science Research and Technologies, Biology of Cancer and Infection, Grenoble, France; University of Grenoble Alpes, Unité mixte de recherche-S1036, 17, rue des Martyrs, Grenoble, France.
Francis
F
Hérodin
Diane
D
Voir
Isabelle
I
Vilgrain
Marie
M
Courçon
Michel
M
Drouet
François-Xavier
FX
Boittin
D000818:Animals; D015703:Antigens, CD / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001853:Bone Marrow / Q000528:radiation effects*; D001855:Bone Marrow Diseases / Q000209:etiology / Q000517:prevention & control; D015820:Cadherins / Q000097:blood*; D008297:Male; D009389:Neovascularization, Pathologic / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D010215:Papio; D011832:Radiation Injuries / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014657:Vasculitis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D014916:Whole-Body Irradiation / Q000009:adverse effects*; D000099152:Cadherin 5
D015703:Antigens, CD; D015415:Biomarkers; D015820:Cadherins; D000099152:Cadherin 5