Clinical and genetic features of lung squamous cell cancer in never-smokers.
To evaluate the importance of specific driver mutations to the development and outcome of lung squamous cell cancer (SQCC) in never-smokers, we assessed the clinicopathological characteristics and outcomes of 597 patients who underwent complete resection of SQCCs. In total, 88 (14.7%) never-smokers and 509 (85.3%) ever-smokers were compared. The never-smokers included more females (42.05% vs. 1.57%, P < 0.001) and more often had a personal history of malignant disease (9.09% vs. 2.36%, P = 0.003). The tumors of never-smokers were more often poorly differentiated (70.45% vs. 53.24%, P = 0.010) and more often contained oncogenic mutations (21.05% vs 11.05%, P = 0.023), particularly EGFR mutations (13.16% vs 3.40%, P = 0.001). Never-smokers also tended to have poorer OS than smokers. Our results suggest lung SQCCs in never-smokers are a subtype distinct from SQCCs occurring in smokers.
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Yangle
Y
Huang
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
Rui
R
Wang
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Yunjian
Y
Pan
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Yang
Y
Zhang
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Hang
H
Li
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Chao
C
Cheng
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Difan
D
Zheng
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Shanbo
S
Zheng
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Yuan
Y
Li
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Xuxia
X
Shen
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Haichuan
H
Hu
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Deng
D
Cai
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Shengfei
S
Wang
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Yawei
Y
Zhang
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Jiaqing
J
Xiang
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Yihua
Y
Sun
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Jie
J
Zhang
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Haiquan
H
Chen
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000074285:Smokers / Q000706:statistics & numerical data; D012907:Smoking
D066246:ErbB Receptors
clinicopathological characteristics; genetic features; never-smoker; squamous cell lung cancer