Diagnostic Utility of Neuregulin for Acute Coronary Syndrome.
The purpose of this study was to determine the diagnostic test characteristics of serum neuregulin-1β (NRG-1β) for the detection of acute coronary syndrome (ACS). We recruited emergency department patients presenting with signs and symptoms prompting an evaluation for ACS. Serum troponin and neuregulin-1β levels were compared between those who had a final discharge diagnosis of myocardial infarction (STEMI and NSTEMI) and those who did not, as well as those who more broadly had a final discharge diagnosis of ACS (STEMI, NSTEMI, and unstable angina). Of 319 study participants, 11% had evidence of myocardial infarction, and 19.7% had a final diagnosis of ACS. Patients with MI had median neuregulin levels of 0.16 ng/mL (IQR [0.16-24.54]). Compared to the median of those without MI, 1.46 ng/mL (IQR [0.16-15.02]), there was no significant difference in the distribution of results (P = 0.63). Median neuregulin levels for patients with ACS were 0.65 ng/mL (IQR [0.16-24.54]). There was no statistical significance compared to those without ACS who had a median of 1.40 ng/mL (IQR [0.16-14.19]) (P = 0.95). Neuregulin did not perform successfully as a biomarker for acute MI or ACS in the emergency department.
Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA.
Maame Yaa A B
0000-0002-6479-0764
MY
Yiadom
Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA.
Jeremy
J
Greenberg
Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Holly M
HM
Smith
Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Douglas B
DB
Sawyer
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Dandan
D
Liu
Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA.
Jahred
J
Carlise
Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA.
Laura
L
Tortora
Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA.
Alan B
AB
Storrow
D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000378:metabolism*; D000368:Aged; D042241:Early Diagnosis; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000378:metabolism*; D020890:Neuregulin-1 / Q000097:blood*; D010865:Pilot Projects; D020033:Protein Isoforms / Q000097:blood; D012701:Serotonin / Q000097:blood*
C094131:NRG1 protein, human; D020890:Neuregulin-1; D020033:Protein Isoforms; D012701:Serotonin