First Report of the 23S rRNA Gene A2058G Point Mutation Associated With Macrolide Resistance in Treponema pallidum From Syphilis Patients in Cuba.
This study aimed to assess the presence of macrolide-resistant Treponema pallidum subtypes in Havana, Cuba. Samples from 41 syphilis patients were tested for T. pallidum 23S rRNA gene mutations. Twenty-five patients (61%) harbored T. pallidum with the A2058G mutation, which was present in all 8 subtypes that were identified. The A2059G mutation was not detected.
From the *Tropical Medicine Institute "Pedro Kourí", Havana, Cuba; and †Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Angel A
AA
Noda
Nelvis
N
Matos
Orestes
O
Blanco
Islay
I
Rodríguez
Lola Virginia
LV
Stamm
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D003462:Cuba / Q000453:epidemiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D013587:Syphilis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D014210:Treponema pallidum / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D055815:Young Adult
D000900:Anti-Bacterial Agents; D018942:Macrolides; D017963:Azithromycin