Specific Antigens by Federal Entity in Patients at the Transplant Unit of Specialities Hospital, National Medical Center Twenty-First Century, Mexico.
BACKGROUND
The study of the kidney transplant involves understanding the immunologic basis, such as histocompatibility and the genetic basis of a population. In Mexico, the study of the genetic basis has led to a genetic map by federal entities.


METHODS
We performed an HLA study with 1,276 kidney transplant patients (recipients and donors) in the Hospital of the National Medical Center Twenty-First Century, determining HLA class I (A, B, and Cw) and class II (DRβ1 and DQβ1) antigens with the use of SSOP-PCR. A descriptive analysis was conducted with measures of central tendency (mean, SD).


RESULTS
Of 1,276 HLA patients studied, we obtained 2,552 results for each class by the composition of the 2 haplotypes, and for HLA-Cw we processed 796 patients, for a total of 1,592 antigens for this class. We found antigens specific to each federal entity, and it was found that the Federal District had the highest number of specific antigens (10) followed by Morelos (7), Querétaro and Mexico State (3 each), and Tamaulipas, Aguascalientes, Michoacán, Guerrero, Puebla, and Oaxaca (1 each).


CONCLUSIONS
The genetic map allows us to know proportions of antigens in every state in the center and south of Mexico owing to the diversity and area of influence of the National Medical Center XXIst Century, as well as the wide number of patients. Furthermore, there are still preserved proportionally distinct genetic roots in every entity.
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México. Electronic address: juancarloshhernandezrivera@hotmail.com.
J C H
JC
Hernández Rivera
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
A
A
Ibarra Villanueva
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
R
R
Espinoza Pérez
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
J D
JD
Cancino López
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
I R
IR
Silva Rueda
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
R
R
Rodríguez Gómez
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
L
L
García Covarrubias
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
E
E
Reyes Díaz
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
M J
MJ
Pérez López
Specialty Hospital "Dr. Bernardo Sepúlveda Gutiérrez" National Medical Center XXI Century, Instituto Mexicano del Seguro Social, México.
M
M
Salazar Mendoza
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004247:DNA / Q000235:genetics*; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006239:Haplotypes; D006782:Hospitals, Special; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008800:Mexico; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D055815:Young Adult
D015236:HLA-C Antigens; D004247:DNA