From Mosquitos to Humans: Genetic Evolution of Zika Virus.
Initially isolated in 1947, Zika virus (ZIKV) has recently emerged as a significant public health concern. Sequence analysis of all 41 known ZIKV RNA open reading frames to date indicates that ZIKV has undergone significant changes in both protein and nucleotide sequences during the past half century.
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.
Lulan
L
Wang
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Stephanie G
SG
Valderramos
Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.
Aiping
A
Wu
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Songying
S
Ouyang
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chunfeng
C
Li
Instituto Nacional de Infectologia Evandro Chagas, Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, CEP 21040-900, Brasil.
Patricia
P
Brasil
Laboratorio Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, CEP 21040-900, Brasil.
Myrna
M
Bonaldo
UCLA Center for World Health, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Thomas
T
Coates
Division of Pediatric Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Karin
K
Nielsen-Saines
Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address: jtj@ism.cams.cn.
Taijiao
T
Jiang
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: aliyarirs@ucla.edu.
Roghiyh
R
Aliyari
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address: gcheng@mednet.ucla.edu.
Genhong
G
Cheng
D000349:Africa / Q000453:epidemiology; D019943:Amino Acid Substitution; D000818:Animals; D001208:Asia / Q000453:epidemiology; D009033:Culicidae / Q000821:virology*; D019143:Evolution, Molecular; D014644:Genetic Variation; D006801:Humans; D017720:Molecular Epidemiology; D058974:Phylogeography; D017421:Sequence Analysis; D014759:Viral Envelope Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics; D000071244:Zika Virus / Q000235:genetics* / Q000302:isolation & purification; D000071243:Zika Virus Infection / Q000453:epidemiology / Q000821:virology*
D014759:Viral Envelope Proteins; D014764:Viral Proteins; C074932:prM protein, Flavivirus