Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.
There is accumulating evidence that the histone methyltransferase enhancer of zeste homolog 2 (EZH2), the main component of the polycomb-repressive complex 2 (PRC2), is involved in melanoma progression and metastasis. Novel drugs that target and reverse such epigenetic changes may find a way into the management of patients with advanced melanoma. We provide a comprehensive up-to-date review of the role and biology of EZH2 on gene transcription, senescence/apoptosis, melanoma microenvironment, melanocyte stem cells, the immune system, and micro RNA. Furthermore, we discuss EZH2 inhibitors as potential anti-cancer therapy.
a Department of Internal Medicine, Division of Hematology/Oncology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Fade
F
Mahmoud
b Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Bradley
B
Shields
a Department of Internal Medicine, Division of Hematology/Oncology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Issam
I
Makhoul
a Department of Internal Medicine, Division of Hematology/Oncology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Laura F
LF
Hutchins
c Departments of Pathology and Dermatology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Sara C
SC
Shalin
b Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Alan J
AJ
Tackett
D018450:Disease Progression; D000071221:Enhancer of Zeste Homolog 2 Protein / Q000378:metabolism*; D057890:Epigenomics; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D009362:Neoplasm Metastasis
D006657:Histones; D000071221:Enhancer of Zeste Homolog 2 Protein
Chromatin; EZH2; H3K27 trimethylation; epigenetic changes; histone; melanoma; polycomb-repressive complex