Genetic Variants in SDC3 Gene are Significantly Associated with Growth Traits in Two Chinese Beef Cattle Breeds.
Identification of the genes and polymorphisms underlying quantitative traits, and understanding these genes and polymorphisms affect economic growth traits, are important for successful marker-assisted selection and more efficient management strategies in commercial cattle (Bos taurus) population. Syndecan-3 (SDC3), a member of the syndecan family of type I transmembrane heparan sulfate proteoglycans is a novel regulator of feeding behavior and body weight. The aim of this study is to examine the association of the SDC3 polymorphism with growth traits in Chinese Jiaxian and Qinchuan cattle breeds (). Four single nucleotide polymorphisms (SNPs: 1-4) were detected in 555 cows from three Chinese native cattle breeds by means of sequencing pooled DNA samples and polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) methods. We found one SNP (g.28362A > G) in intron and three SNPs (g.30742T > G, g.30821C > T and 33418 A > G) in exons. The statistical analyses indicated that these SNPs of SDC3 gene were associated with bovine body height, body length, chest circumference, and circumference of cannon bone (P < 0.05). The mutant-type variant was superior for growth traits; the heterozygote was associated with higher growth traits compared to wild-type homozygote. Our result confirms the polymorphisms in the SDC3 gene are associated with growth traits that may be used for marker-assisted selection in beef cattle breeding programs.
a Institute of Cellular and Molecular Biology , Jiangsu Normal University , Xuzhou Jiangsu , China.|b College of Animal Science and Technology , Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture , Yangling Shaanxi , China.
Yong-Zhen
YZ
Huang
a Institute of Cellular and Molecular Biology , Jiangsu Normal University , Xuzhou Jiangsu , China.
Qin
Q
Wang
a Institute of Cellular and Molecular Biology , Jiangsu Normal University , Xuzhou Jiangsu , China.
Chun-Lei
CL
Zhang
a Institute of Cellular and Molecular Biology , Jiangsu Normal University , Xuzhou Jiangsu , China.
Xing-Tang
XT
Fang
c Institute of Animal Husbandry and Veterinary , Shandong Academy of Agricultural Sciences , Jinan , Shandong , China.
En-Liang
EL
Song
a Institute of Cellular and Molecular Biology , Jiangsu Normal University , Xuzhou Jiangsu , China.
Hong
H
Chen
D000818:Animals; D049628:Body Size / Q000235:genetics*; D001947:Breeding; D002417:Cattle; D002681:China; D005260:Female; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D053670:Syndecan-3 / Q000235:genetics*
D053670:Syndecan-3
Association; SDC3; SNPs; cattle; growth trait