Intolerable secretion and diabetes in tolerant transgenic mice, revisited.
A new mouse model linking diabetes, insulin secretion and autoimmunity with a high-fat diet supports a shared mechanism for type 1 (T1D) and type 2 (T2D) diabetes. In this model, the protein secretion system of insulin-producing pancreatic beta cells is stressed, leading to increased beta cell apoptosis and diabetes via reduced levels of the transcription factor GLIS3, a pathogenic pathway that can be mimicked by a high-fat diet.
JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrookes Hospital, Cambridge, UK.
John A
JA
Todd
D000818:Animals; D003920:Diabetes Mellitus; D003924:Diabetes Mellitus, Type 2; D007328:Insulin; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells; D051379:Mice; D008822:Mice, Transgenic
D007328:Insulin