Computational fluid dynamics for the assessment of upper airway changes in skeletal Class III patients treated with mandibular setback surgery.
OBJECTIVE
To analyze and compare pharyngeal airflow characteristics pre- and post-mandibular setback surgery in patients with Class III skeletal dysplasia using cone beam computed tomography (CBCT) and computational fluid dynamics (CFD).


METHODS
Records of 29 patients who had received orthodontic treatment along with mandibular setback surgery were obtained. CBCT scans were obtained at three time points: T1 (before surgery), T2 (average of 6 months after surgery), and T3 (average of 1 year after surgery). Digitized pharyngeal airway models were generated from these scans. CFD was used to simulate and characterize pharyngeal airflow.


RESULTS
Mean airway volume was significantly reduced from 35,490.324 mm3at T1 to 24,387.369 mm3at T2 and 25,069.459 mm3at T3. Significant increase in mean negative pressure was noted from 3.110 Pa at T1 to 6.116 Pa at T2 and 6.295 Pa at T3. There was a statistically significant negative correlation between the change in airway volume and the change in pressure drop at both the T2 and T3 time points. There was a statistically significant negative correlation between the amount of mandibular setback and change in pressure drop at the T2 time point.


CONCLUSIONS
Following mandibular setback surgery, pharyngeal airway volume was decreased and relative mean negative pressure was increased, implying an increased effort required from a patient for maintaining constant pharyngeal airflow. Thus, high-risk patients undergoing a large amount of mandibular setback surgery should be evaluated for obstructive sleep apnea and the proposed treatment plan be revised based on the risk for potential airway compromise.
Darshit H
DH
Shah
Ki Beom
KB
Kim
Mark W
MW
McQuilling
Reza
R
Movahed
Ankit H
AH
Shah
Yong I
YI
Kim
D000293:Adolescent; D000328:Adult; D002508:Cephalometry; D054893:Cone-Beam Computed Tomography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057446:Hydrodynamics; D008297:Male; D008313:Malocclusion, Angle Class III / Q000601:surgery*; D008334:Mandible; D008875:Middle Aged; D010614:Pharynx / Q000033:anatomy & histology*; D055815:Young Adult
Airway volume; Computational fluid dynamics; Mandibular setback surgery; Negative airway pressure; Obstructive sleep apnea (OSA); Upper airway changes