Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential.
A recent study provides a platform for generating infectious coronavirus genomes using sequence data, examining their capabilities of replicating in human cells and causing diseases in animal models, and evaluating therapeutics and vaccines. Similar approaches could be used to assess the potential of human emergence and pathogenicity for other viruses.
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Department of Microbiology, The University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310006, China. Electronic address: skplau@hku.hk.
Susanna K P
SKP
Lau
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Department of Microbiology, The University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310006, China. Electronic address: pcywoo@hku.hk.
Patrick C Y
PCY
Woo
D000818:Animals; D021821:Communicable Diseases, Emerging / Q000235:genetics; D017934:Coronavirus / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity*; D018352:Coronavirus Infections / Q000178:diet therapy / Q000517:prevention & control / Q000821:virology*; D004279:DNA, Viral; D004195:Disease Models, Animal; D005818:Genetic Engineering; D016679:Genome, Viral; D006801:Humans; D011995:Recombination, Genetic
D004279:DNA, Viral