A new triterpene glycoside from the stems of Lagerstroemia indica.
A bioassay-guided fractionation and chemical investigation of the stems of Lagerstroemia indica resulted in the isolation and identification of a new triterpene glycoside, lagerindiside (1), along with nine known triterpenes (2-10). The structure of this new compound was elucidated on the basis of 1D and 2D nuclear magnetic resonance spectroscopic data analysis as well as chemical method. The cytotoxic activities of the isolates (1-10) were evaluated by determining their inhibitory effects on four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) using a sulforhodamine B bioassay. Compounds 3 and 4 showed potent cytotoxicity on the tumor cell lines with IC50 values ranging from 3.38 to 6.29 μM.
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-ku, Suwon, Gyeonggi-do, 440-746, Republic of Korea.
Kyeong Wan
KW
Woo
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-ku, Suwon, Gyeonggi-do, 440-746, Republic of Korea.
Joon Min
JM
Cha
Korea Research Institute of Chemical Technology, Daejeon, 305-600, Republic of Korea.
Sang Un
SU
Choi
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-ku, Suwon, Gyeonggi-do, 440-746, Republic of Korea. krlee@skku.edu.
Kang Ro
KR
Lee
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D055808:Drug Discovery / Q000379:methods*; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D031563:Lagerstroemia / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes
Cytotoxicity; Lagerstroemia indica; Lythraceae; Triterpene glycoside