Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway.
Increasing emphasis has been put on the influence of desmosome related proteins on progress of colorectal cancer (CRC). Pinin (PNN) is a desmosome-associated molecule that has been reported its overexpression could increase desmoglein 2 (DSG2) and E-cadherin (E-ca) levels. However, it was documented that DSG2 and E-ca had opposite functions in CRC. Thus, we attempted to elucidate function and mechanism of PNN in CRC. Herein, we revealed that overexpression of PNN was significantly correlated with the aggressive characteristics and indicated poor overall survival of CRC patients. In addition, the proliferation, invasion in vitro, and tumorigenic growth, metastasis in vivo were also promoted by the up-regulation of PNN. It was also verified that up-regulation of PNN increased the expression of DSG2 and activated the EGFR/ERK signaling pathway. Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of CRC.
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhigang
Z
Wei
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wenhui
W
Ma
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaolong
X
Qi
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xianjun
X
Zhu
Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yutian
Y
Wang
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhuoluo
Z
Xu
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jun
J
Luo
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Da
D
Wang
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Weihong
W
Guo
Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaomei
X
Li
Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Sainan
S
Xin
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.|Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiang
J
Yu
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Guoxin
G
Li
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D018450:Disease Progression; D066246:ErbB Receptors / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D064593:Heterografts; D006801:Humans; D053208:Kaplan-Meier Estimate; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D015398:Signal Transduction / Q000502:physiology
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D009687:Nuclear Proteins; C102646:PNN protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; D048049:Extracellular Signal-Regulated MAP Kinases
EGFR/ERK; PNN; colorectal cancer; metastasis