Novel correlates between antimüllerian hormone and menstrual cycle characteristics in African-American women (23-35 years-old).
To characterize normative antimüllerian hormone (AMH) levels and ascertain which factors are associated with AMH in a large cohort of reproductive-age women.



Cross-sectional study.



Not applicable.



A total of 1,654 African-American women (AAW) ages 23-34 at recruitment.



Not applicable.



Serum AMH measured using an ultrasensitive ELISA.



The median AMH was 3.18 ng/mL, and there was a significant, but nonlinear, relationship between age and AMH, with levels peaking at age 25. As AMH was not normally distributed, log transformation was performed and used for all analyses. In a multivariable age-adjusted model, body mass index, current use of hormonal contraception, and history of a thyroid condition were inversely associated with AMH, while history of abnormal menstrual bleeding and menstrual cycles longer than 35 days were positively associated with AMH.



While age is correlated with AMH, it accounts for only a portion of the variation seen. This study adds valuable information to the existing literature on normative AMH levels in young reproductive-age women. While our findings fill a critical data gap for ovarian reserve in AAW, the insights gained will be of benefit for all women.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: erica-marsh@northwestern.edu.
Erica E
EE
Marsh
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Lia A
LA
Bernardi
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Marissa L
ML
Steinberg
Department of Preventive Medicine, Northwestern University, Chicago, Illinois.
Peter J
PJ
de Chavez
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Jenny A
JA
Visser
Department of Preventive Medicine, Northwestern University, Chicago, Illinois.
Mercedes R
MR
Carnethon
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Donna D
DD
Baird
D000328:Adult; D001741:Black or African American; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016014:Linear Models; D008597:Menstrual Cycle / Q000208:ethnology*; D008824:Michigan / Q000453:epidemiology; D015999:Multivariate Analysis; D065851:Ovarian Reserve; D055815:Young Adult
D015415:Biomarkers; D054304:Anti-Mullerian Hormone
AMH; African-American women; ovarian reserve