The lipid profile in obese asthmatic children compared to non-obese asthmatic children.
BACKGROUND
A relationship between asthma and obesity has been documented in children and adolescents. An alternate day calorie restriction diet has been reported to improve asthma symptoms by decreasing levels of serum cholesterol and triglycerides, reducing markers of oxidative stress and increasing levels of the antioxidant uric acid. Therefore, to investigate the lipid profile in asthmatic children may be important in asthma control treatment.


METHODS
One hundred and sixty newly diagnosed persistent asthmatic children were selected to participate in the study. They were divided into four groups based on their body mass index (BMI): Group I normal weight (BMI=20-24.9kg/m(2), n=30); Group II under-weight (BMI<20kg/m(2), n=30); Group III overweight (BMI=25-30kg/m(2), n=25); and Group IV obese (BMI>30kg/m(2), n=25). Fasting blood sugar, fasting insulin, and HbA1c were measured to exclude the possibility of pre-diabetes. Lipid profile measurements included total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apo-A1, apo-B and triglycerides.


RESULTS
There were no significant differences in the levels of apo-A1, apo-B, triglycerides, cholesterol and LDL in all four groups. Only the level of HDL was higher in GIV>GIII>GII>GI (75.84±13.95, 68.56±15.28, 64.17±13.93, 63.17±14.34mg/dl, respectively). There were no cases of pre-diabetes in any of the four groups.


CONCLUSIONS
Hypercholesterolaemia and hypertriglyceridaemia were not found in any of the persistent asthmatic children, and thus they are not high risk factors for asthma. Similarly, there were no differences in apo-A1 and apo-B between any of the BMI groups. No differences were found in LDL levels, however HDL levels were increased in all four groups, indicating that allergic sensitisation may have occurred. Controlling body weight and restricting calorie intake may be as important as appropriate pharmacological management in controlling asthma.
Department of Pediatrics, Taipei City Hospital-Mother & Child Branch, Taiwan.
L-J
LJ
Fang
Department of Pediatrics, Taipei City Hospital-Renai Branch, Taiwan.
C-S
CS
Huang
Department of Pediatrics, Taipei City Hospital-Renai Branch, Taiwan.
Y-C
YC
Liu
Department of Pediatrics, Taipei City Hospital-Renai Branch, Taiwan.
Y-M
YM
Su
Department of Pediatrics, Taipei City Hospital-Renai Branch, Taiwan. Electronic address: gwan1998@gmail.com.
K-S
KS
Wan
D000293:Adolescent; D001249:Asthma / Q000097:blood* / Q000453:epidemiology* / Q000209:etiology; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications / Q000453:epidemiology*; D005215:Fasting / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
Asthmatic children; Hypercholesterolemia; Hypertriglyceridemia; Lipid profile; Obesity; Pre-diabetes