Yuccalides A-C, three new phenolic compounds with spiro-structures from the roots of Yucca gloriosa.
Three new phenolic compounds, yuccalides A-C (1-3), were isolated from the roots of Yucca gloriosa L., along with four known compounds (4-7). The structures of the new compounds were established by extensive NMR spectroscopic analyses. Inducible nitric oxide synthase (iNOS) mRNA levels induced by lipopolysaccharide (LPS) in mouse macrophage-like RAW 264.7 cells were effectively suppressed by compounds 2, 4, and 6, all of which had the (2R*, 3R*)-configuration. IL-1β and IL-6 mRNA levels induced by LPS were significantly attenuated by compounds 4, 5, and 6, but not by 2.
Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan. Electronic address: nakasima@dpc.agu.ac.jp.
Ken-Ichi
K
Nakashima
Laboratory of Pharmacognosy, Department of Bioactive Molecules, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
Naohito
N
Abe
Laboratory of Pharmacognosy, Department of Bioactive Molecules, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
Masayoshi
M
Oyama
Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
Makoto
M
Inoue
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification; D027623:Yucca / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D053583:Interleukin-1beta; D015850:Interleukin-6; D010636:Phenols; D013141:Spiro Compounds; C000613426:yuccalide B; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse
Anti-inflammatory; Asparagaceae; Spiro-structure; Yucca gloriosa L.; Yuccalides A–C