Association between alcohol consumption and amyotrophic lateral sclerosis: a meta-analysis of five observational studies.
The purpose of this study is to examine the association between alcohol consumption and amyotrophic lateral sclerosis. Published literature on the association between alcohol consumption and amyotrophic lateral sclerosis was retrieved from the PubMed and Embase databases. Two authors independently extracted the data. The quality of the identified studies was evaluated according to the Newcastle-Ottawa scale. Subgroup and sensitivity analyses were performed and publication bias was assessed. Five articles, including one cohort study and seven case-control studies, and a total of 431,943 participants, were identified. The odds ratio for the association between alcohol consumption and amyotrophic lateral sclerosis was 0.57 (95 % confidence interval 0.51-0.64). Subgroup and sensitivity analyses confirmed the result. Evidence for publication bias was detected. Alcohol consumption reduced the risk of developing amyotrophic lateral sclerosis compared with non-drinking. Alcohol, therefore, has a potentially neuroprotective effect on the development of amyotrophic lateral sclerosis.
Yangzhou Center for Disease Control and Prevention, 36 Yanfu Dong Road, Yangzhou, 225001, Jiangsu, People's Republic of China.|Institute of Occupational Health and Environmental Health, Shandong University, 44 Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China.
Meng
M
E
Institute of Occupational Health and Environmental Health, Shandong University, 44 Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China. sufangyu@sdu.edu.cn.
Sufang
S
Yu
Yangzhou Center for Disease Control and Prevention, 36 Yanfu Dong Road, Yangzhou, 225001, Jiangsu, People's Republic of China.
Jianrui
J
Dou
Yangzhou Center for Disease Control and Prevention, 36 Yanfu Dong Road, Yangzhou, 225001, Jiangsu, People's Republic of China.
Wu
W
Jin
Yangzhou Center for Disease Control and Prevention, 36 Yanfu Dong Road, Yangzhou, 225001, Jiangsu, People's Republic of China.
Xiang
X
Cai
Yangzhou Center for Disease Control and Prevention, 36 Yanfu Dong Road, Yangzhou, 225001, Jiangsu, People's Republic of China.
Yiyang
Y
Mao
Yangzhou Center for Disease Control and Prevention, 36 Yanfu Dong Road, Yangzhou, 225001, Jiangsu, People's Republic of China.
Daojian
D
Zhu
Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, 225001, Jiangsu, People's Republic of China.
Rumei
R
Yang
D000428:Alcohol Drinking / Q000453:epidemiology*; D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D006801:Humans; D064887:Observational Studies as Topic; D012307:Risk Factors
Alcohol consumption; Amyotrophic lateral sclerosis; Meta-analysis