Influence of APOE Genotype on Alzheimer's Disease CSF Biomarkers in a Spanish Population.
OBJECTIVE
To evaluate the association between apolipoprotein E (APOE) genotype and cerebrospinal fluid (CSF) levels of Alzheimer's disease (AD) biomarkers and to study the influence of APOE genotype on the development of AD in a Spanish population.


METHODS
The study comprised 29 amnestic mild cognitive impairment (MCI) patients and 27 control subjects. Using ELISA methodology, CSF biomarkers and tau/Aβ ratios were obtained. ANOVA and adjusted odds ratios were calculated.


RESULTS
We observed the effect of APOE genotype and age on CSF AD variables. The progression to AD was more clearly influenced by CSF AD variables than by age or APOE status.


CONCLUSIONS
APOE status influences CSF AD variables. However, the presence of APOE ε4 does not appear to be a deterministic factor for the development of AD, because CSF variables have a greater influence on progression to the disease. These results confirm previous observations and, to our knowledge, are the first published in a Spanish population.
Department of Neurology, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain.
J A
JA
Monge-Argilés
Department of Neurology, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain.
R
R
Gasparini-Berenguer
Genetics Laboratory, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain.
M
M
Gutierrez-Agulló
Immunology Laboratory, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain.
C
C
Muñoz-Ruiz
Department of Preventive Medicine, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain.
J
J
Sánchez-Payá
Department of Neurology, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain.
C
C
Leiva-Santana
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000473:pathology; D053327:Apolipoprotein E4 / Q000134:cerebrospinal fluid* / Q000235:genetics; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain; D016875:tau Proteins / Q000134:cerebrospinal fluid* / Q000235:genetics
D053327:Apolipoprotein E4; D015415:Biomarkers; D016875:tau Proteins