The CKD Outcomes and Practice Patterns Study (CKDopps): Rationale and Methods.
Minimizing clinical complications in patients with advanced chronic kidney disease (CKD) and improving the transition to dialysis therapy and transplantation represents a challenge, requiring reliable evidence regarding the effects of CKD care on outcomes.



The CKD Outcomes and Practice Patterns Study (CKDopps) is a new international prospective cohort study designed to describe and evaluate variation in nephrologist-led CKD practices.



CKDopps is underway in Brazil, France, Germany, Japan, and the United States. Diverse national samples of nephrology clinics are being recruited based on random selection stratified by geographic region and clinic characteristics. CKDopps aims to enroll 12,200 non-dialysis-dependent patients with CKD (75% and 25% with estimated glomerular filtration rates < 30 and 30-<60mL/min/1.73m(2), respectively) to be followed up for 3 to 5 years.



Demographic, comorbid condition, laboratory, and treatment-related variables are collected at 6-month intervals; patient-reported data are collected annually and more frequently near the transition to end-stage kidney disease; nephrologist practice surveys are collected annually.



Outcomes include mortality, end-stage kidney disease, other clinical events (eg, acute kidney injury, hospitalizations, infections, cardiovascular events, and transplant wait-listing), and patient-reported outcomes.



For the targeted sample size of 12,200 patients and 160 clinics, CKDopps has 80% power to detect HRs of 1.31 for mortality and 1.19 for mortality or transition to end-stage kidney disease.



CKDopps does not capture care provided in settings outside nephrology clinics (eg, primary care) or patients with CKD not receiving medical care.



CKDopps is designed to characterize nephrology clinic practice variation and identify practices associated with better outcomes, with particular focus on advanced CKD, transition to end-stage kidney disease, and the patient experience. Because data will be collected during routine clinical care in real-world practice, analyses may yield practical readily implementable findings. CKDopps aims to establish a multinational infrastructure for research, collaboration, and ancillary investigation. Additional countries are encouraged to join.
Arbor Research Collaborative for Health, Ann Arbor, MI; University of Michigan, Ann Arbor, MI. Electronic address: laura.mariani@arborresearch.org.
Laura
L
Mariani
University Paris-Saclay, University Paris-Sud, UVSQ, CESP, Centre for Research in Epidemiology and Population Health, Inserm UMR1018, F-CRIN-INI-CRCT, Villejuif, France.
Bénédicte
B
Stengel
Service de Néphrologie Transplantation Dialyse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France; Inserm, U1026, Universitaire Bordeaux, Bordeaux, France.
Christian
C
Combe
University Paris-Saclay, University Paris-Sud, UVSQ, CESP, Centre for Research in Epidemiology and Population Health, Inserm UMR1018, F-CRIN-INI-CRCT, Villejuif, France; Division of Nephrology, Ambroise Paré University Hospital, APHP, University of Paris Ouest-Versailles-St-Quentin-en-Yvelines (UVSQ), Boulogne-Billancourt/Paris, France.
Ziad A
ZA
Massy
Nephrological Center, Villingen-Schwenningen, Germany.
Helmut
H
Reichel
Internal Medicine IV - Renal and Hypertensive Diseases, Saarland University Medical Centre, Homburg/Saar, Germany.
Danilo
D
Fliser
School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Roberto
R
Pecoits-Filho
Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BA, Brazil.
Antonio A
AA
Lopes
Department of Nephrology, University of Tsukuba, Tsukuba, Japan.
Kunihiro
K
Yamagata
Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.
Takashi
T
Wada
Arbor Research Collaborative for Health, Ann Arbor, MI.
Michelle M Y
MM
Wong
Arbor Research Collaborative for Health, Ann Arbor, MI.
Elodie
E
Speyer
Arbor Research Collaborative for Health, Ann Arbor, MI; University of Michigan, Ann Arbor, MI.
Friedrich K
FK
Port
Arbor Research Collaborative for Health, Ann Arbor, MI.
Ronald L
RL
Pisoni
Arbor Research Collaborative for Health, Ann Arbor, MI; University of Michigan, Ann Arbor, MI.
Bruce M
BM
Robinson
D006801:Humans; D009398:Nephrology; D017063:Outcome Assessment, Health Care; D010818:Practice Patterns, Physicians'; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D012107:Research Design
CKDopps; Chronic kidney disease (CKD); dialysis; end-stage kidney disease (ESKD); geographic variation; international comparisons; nephrology care; nephrology clinic; patient outcomes; practice patterns; practice variation; renal outcome; transition to ESKD; treatment options