Fibroblasts form a hospitable metastatic niche in the liver.
The liver is the most common metastatic route of pancreatic cancer. Early recruitment of granulin-secreting inflammatory monocytes to the liver is now shown to reprogram hepatic stellate cells into myofibroblasts that modulate the liver microenvironment to support the growth of metastasizing tumour cells.
Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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D005347:Fibroblasts; D055166:Hepatic Stellate Cells; D006801:Humans; D008099:Liver; D058628:Myofibroblasts; D010190:Pancreatic Neoplasms