Targeting Tie2 and the host vascular response in sepsis.
A new therapeutic approach to a complex and dire disease-sepsis-targets a signaling molecule in the vasculature (Hanet al, this issue).
Center for Vascular Biology Research and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. sparikh1@bidmc.harvard.edu.
Samir M
SM
Parikh
D042683:Angiopoietin-1 / Q000235:genetics / Q000378:metabolism; D042702:Angiopoietin-2 / Q000235:genetics / Q000378:metabolism; D000818:Animals; D006801:Humans; D042787:Receptor, TIE-2 / Q000235:genetics / Q000378:metabolism; D018805:Sepsis / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
C467630:ANGPT1 protein, human; C586513:ANGPT2 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042787:Receptor, TIE-2