Non-Genetic Transmission of Obesity - It's in Your Epigenes.
Obesity and its related metabolic comorbidities can be inherited across generations through non-genetic mechanisms. In a recent report, Huypens et al., using an in vitro fertilization approach, provide evidence that exposure to a high-fat diet modifies egg and sperm epigenetic information, rendering the progeny more prone to obesity.
University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Elena
E
Loche
University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. Electronic address: seo10@cam.ac.uk.
Susan E
SE
Ozanne
D059305:Diet, High-Fat / Q000009:adverse effects*; D044127:Epigenesis, Genetic / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D009765:Obesity / Q000209:etiology / Q000235:genetics*; D018812:Paternal Exposure / Q000009:adverse effects