[The effect of 18β-sodium glycyrrhetinic acid on the nasal mucosa epithelial cilia in rat models of allergic rhinitis].
OBJECTIVE
To investigate 18β-sodium glycyrrhetinic acid impact on nasal mucosa epithelial cilia in rat models of allergic rhinitis (AR).


METHODS
AR models were established by ovalbumin-induction. Wister rats were randomly divided into groups as normal group, model group, budesonide (0.2 mg/kg) group and sodium glycyrrhetinic acid (20 mg/kg and 40 mg/kg) group after the success of AR models. At 2 weeks and 4 weeks after treatment, the behavioral changes of rats were observed and recorded, and nasal septum mucosae were collected after 2 week and 4 week intervention, and the morphological changes of nasal mucosae were observed by electron microscope.


RESULTS
Model group developed typical AR symptoms, the total score in all animals was > 5. With budesonide and sodium glycyrrhetinic acid treatment, the AR symptoms were relieved, and the total scores were reduced significantly (P < 0.01). Compared with the model group: after 2 weeks' intervention, thick mucous secretions on the top of columnar epithelium cilia in rat nasal mucosa was significantly reduced, and cilia adhesion, lodging, shedding were relieved in budesonide group and sodium glycyrrhetinic acid group, the relieve in budesonide group was slightly better than that in sodium glycyrrhetinic acid group; after 4 week intervention, Cilia adhesion, lodging, shedding were completely vanished, and the cilia were ranged in regular direction in budesonide group and sodium glycyrrhetinic acid group. Cilia in sodium glycyrrhetinic acid (20 mg/kg) group was more orderly, smooth than that in budesonide group and sodium glycyrrhetinic acid group (40 mg/kg), and the condition of cilia in sodium glycyrrhetinic acid group (20 mg/kg) was similar to the normal group.


CONCLUSIONS
18β-sodium glycyrrhetinic acid is effective to restrain the pathological changes of nasal mucosa cilia in rat models of AR.
Jing
J
Yang
Kehu
K
Xi
Yan
Y
Gui
Youhu
Y
Wang
Fuhong
F
Zhang
Chunxia
C
Ma
Hao
H
Hong
Xiangyi
X
Liu
Nannan
N
Meng
Xiaobing
X
Zhang
D000818:Animals; D019819:Budesonide / Q000494:pharmacology; D002923:Cilia / Q000187:drug effects*; D004195:Disease Models, Animal; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009297:Nasal Mucosa / Q000187:drug effects*; D010047:Ovalbumin; D011897:Random Allocation; D051381:Rats; D065631:Rhinitis, Allergic / Q000188:drug therapy*
C119129:18alpha-glycyrrhetinic acid; D019819:Budesonide; D010047:Ovalbumin; D006034:Glycyrrhetinic Acid