Augmentation of Autoantibodies by Helicobacter pylori in Parkinson's Disease Patients May Be Linked to Greater Severity.
Parkinson's disease (PD) is the second most common chronic and progressive neurodegenerative disorder. Its etiology remains elusive and at present only symptomatic treatments exists. Helicobacter pylori chronically colonizes the gastric mucosa of more than half of the global human population. Interestingly, H. pylori positivity has been found to be associated with greater of PD motor severity. In order to investigate the underlying cause of this association, the Sengenics Immunome protein array, which enables simultaneous screening for autoantibodies against 1636 human proteins, was used to screen the serum of 30 H. pylori-seropositive PD patients (case) and 30 age- and gender-matched H. pylori-seronegative PD patients (control) in this study. In total, 13 significant autoantibodies were identified and ranked, with 8 up-regulated and 5 down-regulated in the case group. Among autoantibodies found to be elevated in H. pylori-seropositive PD were included antibodies that recognize Nuclear factor I subtype A (NFIA), Platelet-derived growth factor B (PDGFB) and Eukaryotic translation initiation factor 4A3 (eIFA3). The presence of elevated autoantibodies against proteins essential for normal neurological functions suggest that immunomodulatory properties of H. pylori may explain the association between H. pylori positivity and greater PD motor severity.
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Gunasekaran
G
Suwarnalata
Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.
Ai Huey
AH
Tan
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Hidayah
H
Isa
Sengenics Sdn Bhd, University of Malaya, Kuala Lumpur, Malaysia.
Ranganath
R
Gudimella
Sengenics Sdn Bhd, University of Malaya, Kuala Lumpur, Malaysia.
Arif
A
Anwar
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Mun Fai
MF
Loke
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Sanjiv
S
Mahadeva
Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.
Shen-Yang
SY
Lim
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Jamuna
J
Vadivelu
D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D039601:Eukaryotic Initiation Factor-4A / Q000276:immunology; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051839:NFI Transcription Factors / Q000276:immunology; D010300:Parkinson Disease / Q000097:blood / Q000150:complications* / Q000276:immunology* / Q000382:microbiology; D020574:Proto-Oncogene Proteins c-sis / Q000276:immunology
D001323:Autoantibodies; D051839:NFI Transcription Factors; C497592:NFIA protein, human; D020574:Proto-Oncogene Proteins c-sis; D039601:Eukaryotic Initiation Factor-4A