Quest for the chemical synthesis of proteins.
The chemical synthesis of proteins has been the wish of chemists since the early 19th century. There were decisive methodological steps necessary to accomplish this aim. Cornerstones were the introduction of the Z-protecting group of Bergmann and Zervas, the development of Solid-phase Peptide Synthesis of Merrifield, and the establishment of Native Chemical Ligation by Kent. Chemical synthesis of proteins has now become generally applicable technique for the synthesis of proteins with tailor made properties which can be applied not only in vitro but also in vivo .Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.
Max Planck Institute for Molecular Physiology, Otto-Hahn-Str. 17, Dortmund, 44227, Germany.
Martin
M
Engelhard
D060326:Chemistry Techniques, Synthetic / Q000266:history* / Q000379:methods; D049673:History, 20th Century; D049674:History, 21st Century; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000266:history; D011506:Proteins / Q000737:chemistry
D010455:Peptides; D011506:Proteins
Merrifield synthesis; chemical synthesis of proteins; expressed protein ligation (EPL); native chemical ligation (NCL)