Intrinsically Zirconium-89 Labeled Gd2 O2 S:Eu Nanoprobes for In Vivo Positron Emission Tomography and Gamma-Ray-Induced Radioluminescence Imaging.
The engineering of a novel dual-modality imaging probe is reported here by intrinsically labeling zirconium-89 ((89) Zr, a positron emission radioisotope with a half-life of 78.4 h) to PEGylated Gd2 O2 S:Eu nanophorphors, forming [(89) Zr]Gd2 O2 S:Eu@PEG for in vivo positron emission tomography/radioluminescence lymph node mapping.
Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China, 710071.|Department of Radiology, University of Wisconsin-Madison, WI, USA, 53705.
Yonghua
Y
Zhan
Department of Radiology, University of Wisconsin-Madison, WI, USA, 53705.|School of Mechanical and Electrical Engineering, Nanchang University, Jiangxi, China, 330000.
Fanrong
F
Ai
Department of Radiology, University of Wisconsin-Madison, WI, USA, 53705.
Feng
F
Chen
Department of Medical Physics, University of Wisconsin-Madison, WI, USA, 53705.
Hector F
HF
Valdovinos
Department of Surgery, University of California-Davis, Sacramento, CA, 95817, USA.
Hakan
H
Orbay
Department of Radiology, University of Wisconsin-Madison, WI, USA, 53705.
Haiyan
H
Sun
Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China, 710071.
Jimin
J
Liang
Department of Medical Physics, University of Wisconsin-Madison, WI, USA, 53705.
Todd E
TE
Barnhart
Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China, 710071.|Institute of Automation, Chinese Academy of Sciences, Beijing, China, 100190.
Jie
J
Tian
Department of Radiology and Medical Physics, University of Wisconsin-Madison, WI, USA, 53705.|University of Wisconsin-Madison Carbone Cancer Center, Madison, WI, USA, 53705.
Weibo
W
Cai
D005720:Gamma Rays; D005732:Gangliosides / Q000737:chemistry; D008163:Luminescent Measurements / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
D005732:Gangliosides; D011868:Radioisotopes; C019403:ganglioside, GD2; D015040:Zirconium; C000615502:Zirconium-89
intrinsic radiolabeling; nanoparticles; positron emission tomography; radioluminescence imaging