Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing.
Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of mechanisms that functionally couple transcription elongation with diverse events that occur on the nascent RNA. This review summarizes the current understanding of the relationship between transcriptional elongation through a chromatin template and co-transcriptional splicing including alternative splicing decisions that affect the expression of most human genes.
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Tassa
T
Saldi
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Michael A
MA
Cortazar
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Ryan M
RM
Sheridan
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA. Electronic address: david.bentley@ucdenver.edu.
David L
DL
Bentley
D017398:Alternative Splicing / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D012322:RNA Precursors; D012333:RNA, Messenger; D012319:RNA Polymerase II
CTD; RNA polymerase II; alternative splicing; kinetic coupling; transcription elongation