Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis.
Pathological angiogenesis of liver which includes liver sinusoidal capillarization due to lose of fenestraes of liver sinusoidal endothelial cells (LSECs) and formation of new vascular, is a crucial mechanism responsible for origination and development of liver fifibrosis and closely involves in the development of cirrhosis and hepatic cancer. Anti-neovascularization medicine such as sorafenib can decrease portosystemic shunts, improve splanchnic hyperdynamic circulation, lower portal hypertension, while it can not be applied in clinic due to its serious toxic and side reactions. Chinese herbal formula can effectively inhibit pathological angiogenesis of liver, improve microcirculation of liver, and decrease the probability of gastrointestinal hemorrhage in cirrhotic patients. Different Chinese herbal formula are of different characteristics on inhibiting pathological angiogenesis in liver fifibrosis, which partly explains synergistic effect of different compatibility of Chinese materia medica and opens up good vista for Chinese medicine against liver fifibrosis through inhibiting angiogenesis.
Shanghai University of Traditional Chinese Medicine, Shanghai, 201023, China. liuliver@vip.sina.com.
Ping
P
Liu
D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000188:drug therapy; D006470:Hemorrhage / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000188:drug therapy*; D008833:Microcirculation / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000150:complications* / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal
Chinese medicine; liver fifibrosis; pathological angiogenesis