[KIM-1 and NGAL as potential biomarkers for the diagnosis and cancer progression].
On the basis of scientific literature, there is growing evidence that KIM-1 and NGAL are interesting and promising biomarkers not only in acute and chronic inflammatory processes but also in oncogenesis. There are a number of studies which investigate their possible use in diagnosis, treatment and monitoring of therapy effectiveness. The results of recent research suggests that they may play an important role in standard oncology practice. Simultaneous measurement of KIM-1 and NGAL in urine can play a crucial role in carcinogenesis assessment and cancer progression. In the future, they can become rapid diagnostic indicators, which allow one to determine cancer subtype leading to biopsy replacement and therapy improvement. In the present work, beside biochemical characteristics of KIM-1 and NGAL, we will also discuss their role in the diagnosis and assessment of development of cancer.
Katedra i Zakład Toksykologii Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu.
Zofia
Z
Marchewka
Katedra i Zakład Toksykologii Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu.
Aneta
A
Tacik
Pracownia Markerów Nefrotoksyczności Środowiskowej.
Agnieszka
A
Piwowar
D000209:Acute-Phase Proteins / Q000378:metabolism / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D018450:Disease Progression; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000378:metabolism / Q000652:urine*; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000652:urine*; D009369:Neoplasms / Q000175:diagnosis* / Q000652:urine; D011518:Proto-Oncogene Proteins / Q000378:metabolism / Q000652:urine*; D011991:Receptors, Virus / Q000378:metabolism; D059349:Urine Specimen Collection
D000209:Acute-Phase Proteins; D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus