Acute and Chronic Allograft Dysfunction in Kidney Transplant Recipients.
Allograft dysfunction after a kidney transplant is often clinically asymptomatic and is usually detected as an increase in serum creatinine level with corresponding decrease in glomerular filtration rate. The diagnostic evaluation may include blood tests, urinalysis, transplant ultrasonography, radionuclide imaging, and allograft biopsy. Whether it occurs early or later after transplant, allograft dysfunction requires prompt evaluation to determine its cause and subsequent management. Acute rejection, medication toxicity from calcineurin inhibitors, and BK virus nephropathy can occur early or later. Other later causes include transplant glomerulopathy, recurrent glomerulonephritis, and renal artery stenosis.
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA. Electronic address: rygoldberg@barnabashealth.org.
Ryan J
RJ
Goldberg
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA.
Francis L
FL
Weng
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA.
Praveen
P
Kandula
D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D012307:Risk Factors
Allograft failure; Allograft rejection; Diagnostic evaluation; Kidney transplant