Pharmacological performance of novel poly-(ionic liquid)-grafted chitosan-N-salicylidene Schiff bases and their complexes.
In our endeavor to develop a new class of pharmacological candidates with antimicrobial and anticancer efficacy, a series of biopolymeric chitosan Schiff bases bearing salicylidene ionic liquid (IL-Sal) brushes (ILCSB1-3, poly-(GlcNHAc-GlcNH2-(GlcN-Sal-IL)) was successfully synthesized by adopting efficient synthetic routes. Unfortunately, metalation trials of these biopolymeric Schiff bases afford the corresponding Ag(I)/M(II) complexes (where M=Co, Pd). These designed architectures were structurally characterized and pharmacologically evaluated for their in vitro antimicrobial, against common bacterial and fungal pathogens, and anticancer activities against human colon carcinoma (HCT-116) cell line. In conclusion functionalization of chitosan with IL-Sal brushes coupled with metalation of formed ILCSBs were synergistically enhanced its antimicrobial and antitumor properties to a great extent. Noteworthy, Ag-ILCSB2 (IC50=9.13μg/mL) was ca. 5-fold more cytotoxic against HCT-116 cell line than ILCSB2 (IC50=43.30μg/mL).
Chemistry Department, Faculty of Science, Suez University, Suez, Egypt; Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine Universität Düsseldorf, Germany. Electronic address: reda_elshaarawi@science.suez.edu.eg.
Reda F M
RF
Elshaarawy
Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, Egypt. Electronic address: toto.zimo@yahoo.com.
Ayaat A
AA
Refaee
Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, Egypt. Electronic address: elsawi_e@yahoo.com.
Emtithal A
EA
El-Sawi
D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D045325:HCT116 Cells; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D052578:Ionic Liquids; D012545:Schiff Bases; C013243:salicylaldehyde; D048271:Chitosan
Antimicrobial; Antitumor; Chitosan Schiff bases; Complexes; Ionic liquids