Antibacterial and biological properties of biofunctionalized nanocomposites on titanium for implant application.
Titanium implants possessing excellent antibacterial activity are highly desirable for the prevention of implant-associated infections. In this study, we demonstrate a simple one-step, water-based procedure for the fabrication of biofunctionalized nanocomposites on titanium for implant application. The formation of biofunctionalized silver nanoparticles with varied biomolecule templates is confirmed by Fourier-transform infrared spectroscopic, contact angle, field-emission scanning electron microscopy, and inductively coupled plasma atomic emission spectrometry analysis. Antibacterial properties of the specimens were determined by challenging them against Staphylococcus aureus The Ag-incorporated titanium shows excellent antibacterial ability against planktonic bacteria in the suspension and ability to prevent bacterial adhesion. The specimens with optimized biomolecule/silver ratio promote osteoblast differentiation. These biofunctionalized silver nanoparticles-doped titanium specimens, with improved antibacterial activity while maintaining healthy osteoblast cellular activity, have promising application in orthopedics, dentistry, and other biomedical devices.
School of Chemistry and Chemical Engineering, Guangxi University, Nanning, China Department of Chemistry, North Carolina State University, Raleigh, NC, USA College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.
Peiyuan
P
Li
School of Chemistry and Chemical Engineering, Guangxi University, Nanning, China zhftong@sina.com suwmail@163.com.
Zhangfa
Z
Tong
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.
Lini
L
Huo
College of Chemistry, Guangxi Teachers Education University, Nanning, China.
Fang
F
Yang
Department of Chemistry, North Carolina State University, Raleigh, NC, USA College of Chemistry, Guangxi Teachers Education University, Nanning, China.
Wei
W
Su
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001422:Bacterial Adhesion; D018441:Biofilms / Q000187:drug effects; D018929:Cell Culture Techniques; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible; D065546:Drug Liberation; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D010006:Osteoblasts / Q000378:metabolism; D019736:Prostheses and Implants; D017207:Rats, Sprague-Dawley; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D012834:Silver; D014025:Titanium
Antibacterial; cytotoxicity; nanoparticle; osteoblasts; silver; titanium