The BECN1-USP19 axis plays a role in the crosstalk between autophagy and antiviral immune responses.
Macroautophagy/autophagy is a conserved intracellular degradation system that traffics substrates including protein aggregates, defunct or disused organelles and invading pathogens to lysosomes via double-membrane vesicles called autophagosomes. BECN1/Beclin 1 functions as a key protein in autophagy initiation and progression; however, the role of BECN1 in innate immunity has not been fully investigated. Recently, we have found that USP19 affects the ubiquitination of BECN1, hence promoting the formation of autophagosomes and inhibiting DDX58/RIG-I-mediated type I interferon signaling.
a Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou , China.|b Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University, Guangzhou , China.
Jun
J
Cui
a Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou , China.|b Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University, Guangzhou , China.
Shouheng
S
Jin
c Center for Inflammation and Epigenetics, Houston Methodist Research Institute , Houston , TX , USA.
Rong-Fu
RF
Wang
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001343:Autophagy / Q000187:drug effects* / Q000502:physiology; D000071186:Beclin-1 / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects* / Q000276:immunology; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism
D000998:Antiviral Agents; C491997:BECN1 protein, human; D000071186:Beclin-1
BECN1; USP19; autophagy; crosstalk; type I interferon; ubiquitination