Ab initio bubble-driven denaturation of double-stranded DNA: Self-mechanical theory.
Among the different theoretical models of the open-site-driven DNA-denaturation found in the literature, very few interests are actually paid to the fundamental unzipping process of the double-stranded DNA within the vicinity of its ground state condensate. In this paper, we address an alternative to better understand the process of denaturation of such a macromolecule by investigating the onset of its dynamics around its equilibrium state. We show that from the initiation of the transcription bubble by the promoter to the termination state, the open-states of the strands evolve dynamically while generating some localized waveguide channels with elastic scattering properties. We properly discuss the nonlinear dynamics of these structures within the viewpoint of the self-mechanical theory while inferring to the physical structure of the findings and their potential issues.
The Abdus Salam International Centre for Theoretical Physics (ICTP), Strada Costiera, 11-I-34151 Trieste, Italy; National Advanced School of Engineering, University of Yaounde I, P.O. Box 8390, Cameroon; Centre d'Excellence en Technologies de l'Information et de la Communication (CETIC), University of Yaounde I, P.O. Box 812, Cameroon; Department of Physics, Faculty of Science, University of Yaounde I, P.O. Box 812, Cameroon. Electronic address: vkuetche@yahoo.fr.
Victor K
VK
Kuetche
D000818:Animals; D004247:DNA / Q000737:chemistry*; D006801:Humans; D008962:Models, Theoretical; D017711:Nonlinear Dynamics; D009691:Nucleic Acid Denaturation; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D004247:DNA
DNA-denaturation; Ground state condensate; Self-mechanical theory; Transcription bubble; Waveguide channels