Disruption of Core Circadian Clock Genes Reduces Leukemia Growth.
The circadian rhythm transcription factors CLOCK and BMAL1 are essential for AML cell growth.
D000818:Animals; D056926:CLOCK Proteins / Q000235:genetics*; D049109:Cell Proliferation; D002470:Cell Survival; D057906:Circadian Clocks / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics*; D055785:Gene Knockdown Techniques; D018390:Gene Targeting; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology
D056926:CLOCK Proteins