Chemical constituents and their bioactivities from the fruits of Vitex negundo var. cannabifolia.
Phytochemical investigation of the fruits of Vitex negundo var. cannabifolia led to the isolation of 22 compounds (1-22). Their structures were elucidated mainly by spectroscopic analysis and comparison with the literature data. Among them, compounds 1 and 2 were two new artificial lignans. Primary bioassay showed that the polymethoxyflavones 9-12 displayed moderate-to-weak cytotoxicity against human HepG2 and rat C6 cell lines, while the triterpenoids 13-17 exhibited significant brine shrimp lethality with LC50values of 7.5-29.4 μM.
a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai , China.
Sheng-Tao
ST
Fang
a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai , China.|c College of Resources and Environment , University of the Chinese Academy of Sciences , Beijing , China.
Na-Na
NN
Kong
a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai , China.|b Chemistry & Chemical Engineering College , Yantai University , Yantai , China.
Bing-Fei
BF
Yan
a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai , China.
Cui-Yun
CY
Yang
a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai , China.
Jian-Hua
JH
Wang
a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai , China.
Su-Jing
SJ
Liu
b Chemistry & Chemical Engineering College , Yantai University , Yantai , China.
Hai-Zhu
HZ
Jin
a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research , Chinese Academy of Sciences , Yantai , China.
Chuan-Hai
CH
Xia
 var. ; brine shrimp lethality; chemical constituent; cytotoxicity