State-of-the-art of regulatory dendritic cells in cancer.
Dendritic cells (DCs) with robust immunosuppressive activity are commonly found in the microenvironment of advanced solid tumors. These innate immune cells are generically termed regulatory DCs and include various subsets such as plasmacytoid, conventional and monocyte-derived/inflammatory populations whose normal function is subverted by tumor-derived signals. This review summarizes recent findings on the nature and function of regulatory DCs, their relationship with other myeloid subsets and unique therapeutic opportunities to abrogate malignant progression through their targeting.
Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: jrconejo@Wistar.org.
Jose R
JR
Conejo-Garcia
Department of Microbiology, Immunology, and Cancer Biology, Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.
Melanie R
MR
Rutkowski
Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.
Juan R
JR
Cubillos-Ruiz
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008264:Macrophages / Q000378:metabolism; D036961:Matrix Attachment Region Binding Proteins / Q000096:biosynthesis; D038042:Myelopoiesis / Q000276:immunology; D049329:Nanostructures; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology*; D016212:Transforming Growth Factor beta / Q000378:metabolism
D036961:Matrix Attachment Region Binding Proteins; C076189:SATB1 protein, human; D016212:Transforming Growth Factor beta; D015232:Dinoprostone
Dendritic cell; Emergency myelopoiesis; Immunosuppression; Tumor immunology; Tumor microenvironment