Abdominal adiposity is an early marker of pulmonary function impairment: Findings from a Mediterranean Italian female cohort.
Abdominal adiposity may influence the respiratory function, especially in women. The aim of this prospective study is to evaluate the predictive role of body mass index (BMI) and waist circumference (WC) on lung function in healthy women.



In 600 women randomly selected from the cohort of the "Progetto ATENA," anthropometric measures such as BMI, WC, and weight gain were recorded at baseline, and the spirometric parameters were measured 10 years later. The percentage values of forced expiratory volume in 1 s (FEV1%) and forced vital capacity (FVC%) and the ratio of FEV1/FVC were compared with the anthropometric measures after adjustment for several variables measured at baseline such as age, height, socioeconomic status, smoking habits, and history of respiratory allergies grouped in a basal model. WC is significantly associated with a decreased FVC (p = 0.008) and an increased ratio of FEV1/FVC (p = 0.031) after adjustment for the covariates of the basal model. The association between BMI and spirometric parameters reaches borderline significance only with the ratio of FEV1/FVC (p = 0.052).



We suggest measuring both BMI and WC to assess the risk of future respiratory impairment.
Department of Medicine and Surgery, Section of Respiratory Diseases, University of Salerno, Salerno, Italy. Electronic address: avatrella@unisa.it.
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Vatrella
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Naples, Italy.
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Calabrese
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
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Mattiello
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
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Panico
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Naples, Italy.
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Costigliola
Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy.
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Chiodini
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
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Panico
D050153:Abdominal Fat / Q000503:physiopathology*; D050154:Adiposity; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007558:Italy; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013147:Spirometry; D013997:Time Factors; D014797:Vital Capacity; D055105:Waist Circumference; D015430:Weight Gain
Abdominal adiposity; Body mass index; Lung function; Obesity; Restrictive ventilatory pattern; Spirometry; Waist circumference; Women