Determination of Serum Ceruloplasmin Concentration in Patients with Primary Open Angle Glaucoma with Cataract and Patients with Cataract Only: A Pilot Study.
BACKGROUND The aim of this article was to describe the role of ceruloplasmin and to report preliminary results of ceruloplasmin concentrations in patients with primary open-angle glaucoma (POAG) with cataract and in patients with only cataract. Glaucoma, a neurodegenerative disease, is a heterogeneous group of conditions characterized by loss of retinal ganglion cells (RGC), their axons, progressive optic nerve damage, and visual field deterioration. MATERIAL AND METHODS The POAG group included 30 patients and the cataract group included 25 patients. RESULTS Ceruloplasmin plays an essential role in iron metabolism and inactivating free radicals. In the presented pilot study, serum ceruloplasmin level was lower in the POAG group in comparison to the group with only cataract. CONCLUSIONS In treating persistent inflammation in the course of glaucoma, antiglaucoma drugs may increase the permeability of the blood-ocular barrier, which may be connected with the lower concentration of serum ceruloplasmin in the glaucoma patients group.
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Monika
M
Sarnat-Kucharczyk
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Wojciech
W
Rokicki
Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
Jolanta
J
Zalejska-Fiolka
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Dorota
D
Pojda-Wilczek
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Ewa
E
Mrukwa-Kominek
D000368:Aged; D002386:Cataract / Q000097:blood* / Q000150:complications*; D002570:Ceruloplasmin / Q000378:metabolism*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood* / Q000150:complications*; D006801:Humans; D008297:Male; D010865:Pilot Projects
D002570:Ceruloplasmin