Use of phenotype microarrays to study the effect of acquisition of resistance to antimicrobials in bacterial physiology.
It is widely accepted that the acquisition of resistance to antimicrobials confers a fitness cost. Different works have shown that the effect of acquiring resistance in bacterial physiology may be more specific than previously thought. Study of these specific changes may help to predict the outcome of resistant organisms in different ecosystems. In addition to changing bacterial physiology, acquisition of resistance either increases or reduces susceptibility to other antimicrobials. In the current article, we review recent information on the effect of acquiring resistance upon bacterial physiology, with a specific focus on studies using phenotype microarray technology.
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: jareales@farm.ucm.es.
Jose A
JA
Reales-Calderon
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: pblanco@cnb.csic.es.
Paula
P
Blanco
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: malcalde@cnb.csic.es.
Manuel
M
Alcalde-Rico
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: fcorona@cnb.csic.es.
Fernando
F
Corona
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: felipe.lira@cnb.csic.es.
Felipe
F
Lira
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: shernando@cnb.csic.es.
Sara
S
Hernando-Amado
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: alebernardini@gmail.com.
Alejandra
A
Bernardini
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: bsanchez@cnb.csic.es.
María B
MB
Sánchez
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Electronic address: jlmtnez@cnb.csic.es.
José L
JL
Martínez
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects*; D018407:Bacterial Physiological Phenomena; D024881:Drug Resistance, Bacterial; D046228:Microarray Analysis / Q000379:methods*; D010641:Phenotype
D000900:Anti-Bacterial Agents
Antibiotic resistance; Bacterial virulence; Biocides; Fitness costs; Phenotype microarrays