Task-Related Dynamic Division of Labor Between Anterior Temporal and Lateral Occipital Cortices in Representing Object Size.
Object size is represented by functionally distinct sectors along the ventral visual pathway. The early visual cortex encodes objects' sensory-retinal size. Subsequently, the occipitotemporal cortex computes objects' canonical size based on statistical regularities of visual features. Although the neurocomputation of size has been studied in a "bottom-up" sensory-driven framework, little is known about how perceptual size information is transformed into conceptual knowledge and how this computation is modulated by "top-down" goal-driven signals. Using continuous theta burst stimulation, we demonstrated that behavioral goal shapes the neurocognitive network underpinning object size. We manipulated the congruency of perceptual versus conceptual object size, which provides a robust behavioral probe reflecting implicit size knowledge. Neurostimulation was targeted at the lateral occipital cortex (LOC), a key region for object perception, or the anterior temporal lobe (ATL), a "hub" of supramodal conceptual processing. We observed striking contextual modulation of the neurocognitive architecture: when human participants judged perceptual size, the congruency effect was significantly attenuated by LOC stimulation but stayed resilient to ATL stimulation. By contrast, when they judged conceptual size, both LOC and ATL stimulation eradicated the otherwise robust effect. Our findings demonstrate disparate functional profiles of the LOC and ATL, providing the first evidence of a malleable network adaptively altering its division of labor with top-down states. The LOC, regardless of task demand, automatically represents "bottom-up" statistical regularities of visual conformation (reflecting typical object size), whereas the ATL contributes to this computation when the context requires semantically based linkage of visual attributes to object recognition.



In the present study, we provide compelling evidence that the "top-down" cognitive state of an observer changes the dynamic interaction between different subregions of the ventral temporal cortex. Using inhibitory neurostimulation combined with a novel paradigm, we demonstrate a flexible division of labor in the neurocognitive architecture that underpins size knowledge: the lateral occipital cortex codes perceptually based aspects (statistical visual configuration of small/large objects), whereas the anterior temporal lobe represents semantically based aspects (object identity), with their involvement interactively weighted by task demand. The interactive nature of the ventral temporal cortex highlights how top-down modulation constrains and shapes neural representations in the visual system.
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, United Kingdom rocco.chiou@manchester.ac.uk matt.lambon-ralph@manchester.ac.uk.
Rocco
R
Chiou
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, United Kingdom rocco.chiou@manchester.ac.uk matt.lambon-ralph@manchester.ac.uk.
Matthew A
0000-0001-5907-2488
MA
Lambon Ralph
D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D013702:Temporal Lobe / Q000502:physiology*; D013826:Theta Rhythm / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D014793:Visual Cortex / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology*
anterior temporal lobe; continuous theta burst stimulation; lateral occipital cortex; object size knowledge; semantic memory; transcranial magnetic stimulation