Amyotrophic lateral sclerosis and motor neuron syndromes in Asia.
While the past 2 decades have witnessed an increasing understanding of amyotrophic lateral sclerosis (ALS) arising from East Asia, particularly Japan, South Korea, Taiwan and China, knowledge of ALS throughout the whole of Asia remains limited. Asia represents >50% of the world population, making it host to the largest patient cohort of ALS. Furthermore, Asia represents a diverse population in terms of ethnic, social and cultural backgrounds. In this review, an overview is presented that covers what is currently known of ALS in Asia from basic epidemiology and genetic influences, through to disease characteristics including atypical phenotypes which manifest a predilection for Asians. With the recent establishment of the Pan-Asian Consortium for Treatment and Research in ALS to facilitate collaborations between clinicians and researchers across the region, it is anticipated that Asia and the Pacific will contribute to unravelling the uncertainties in ALS.
Faculty of Medicine, Neurology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia.
N
N
Shahrizaila
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
G
G
Sobue
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
S
0000-0002-4716-8578
S
Kuwabara
Department of Neurology, Hanyang University Medical Center, Seoul, South Korea.
S H
SH
Kim
International Alliance of ALS/MND Associations, Sydney, New South Wales, Australia.
Carol
C
Birks
Department of Neurology, Peking University Third Hospital, Beijing, China.
D S
DS
Fan
Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
J S
JS
Bae
Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
C J
CJ
Hu
Department of Neurology, Institute of Human Behaviour and Allied Sciences (IHBAS), New Delhi, Delhi, India.
M
M
Gourie-Devi
Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Y
Y
Noto
Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
K
K
Shibuya
Faculty of Medicine, Neurology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
K J
KJ
Goh
Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
R
R
Kaji
Department of Neurology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
C P
CP
Tsai
Department of Neurology, Peking Union Medical College Hospital, Beijing, China.
L
L
Cui
Neurology Unit, Calvary Health Care, Bethlehem Hospital, Caulfield, Victoria, Australia.
P
P
Talman
Department of Neurology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
R D
RD
Henderson
The Brain Dynamics Centre, Westmead Millennium Institute, Westmead, NSW and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
S
S
Vucic
Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia.
M C
MC
Kiernan
D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D001208:Asia / Q000453:epidemiology; D018450:Disease Progression; D006801:Humans; D016472:Motor Neuron Disease / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D010641:Phenotype; D013577:Syndrome
ALS; EPIDEMIOLOGY; MOTOR NEURON DISEASE