Current Status and Perspectives in Stem Cell Therapy for Heart.
For most patients, the prognosis of heart failure remains poor despite therapeutic advancement in recent decades. The option of cardiac transplantation is high risk and limited by a shortage of donors. Traditionally, the heart had been considered a terminally differentiated organ incapable of regeneration. However, numerous preclinical and clinical studies have been performed since the first report of cell therapy in heart failure using skeletal myoblasts in 2001. These investigations looked at the promising potential and use of several kinds of stem cells, which could some day dramatically alter the understanding of the regenerative capacity of the heart. To date, although there is no existing cardiac cell therapy that has been conclusively reported to be effective, stem cell-related cardiomyocyte regeneration strategies have become significant areas of research in modern cardiovascular medicine. In this review, we outline a variety of common cell sources, surface biomarkers of stem cells, and provide information related to cardiac cell therapy clinical trials.


BACKGROUND
Clinical trial; Stem cell.
Graduate Institute of Clinical Medicine, Taipei Medical University; ; Division of Cardiology, Linkou Chang Gung Memorial Hospital; ; College of Medicine, Chung Gung University, Taoyuan, Taiwan.
Fen-Chiung
FC
Lin
Graduate Institute of Clinical Medicine, Taipei Medical University; ; Graduate Institute of Pharmacology, National Taiwan University, Taipei;
Wen-Pin
WP
Chen
Division of Cardiology, Linkou Chang Gung Memorial Hospital; ; College of Medicine, Chung Gung University, Taoyuan, Taiwan.
Pao-Hsien
PH
Chu
Graduate Institute of Clinical Medicine, Taipei Medical University;
Kou-Gi
KG
Shyu
Division of Cardiology, Linkou Chang Gung Memorial Hospital; ; College of Medicine, Chung Gung University, Taoyuan, Taiwan.
Ming-Shien
MS
Wen