Late reactions in food-allergic children and adolescents after double-blind, placebo-controlled food challenges.
The time during which children are observed following a double-blind, placebo-controlled food challenge (DBPCFC) varies in clinical practice. There are little data on late reactions (LRs) following DBPCFCs. Therefore, we determined the prevalence, severity and clinical characteristics of late reactions in food-allergic children and adolescents after DBPCFC, and ascertained which factors are associated with, and may predict, LRs. Logistic regression analyses were performed to investigate which factors were associated with LRs and to develop the association and prediction models. A total of 1142 children underwent DBPCFCs (child-test combinations). Of these 1142 child-test combinations, 400 reported LRs following the DBPCFC. LRs in food-allergic children after DBPCFC are poorly predictable and are generally not severe. All LRs, including those on the placebo day, are more frequently reported in younger children. Children who do not experience severe immediate reactions may be safely discharged home 2 h after a DBPCFC.
Department of Pediatric Pulmonology and Pediatric Allergy, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.|GRIAC Research Institute, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
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Saleh-Langenberg
GRIAC Research Institute, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.|Department of General Practice, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
B M J
BM
Flokstra-de Blok
Department of Pediatric Pulmonology and Pediatric Allergy, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
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AlAgla
Department of General Practice, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
B J
BJ
Kollen
Department of Pediatric Pulmonology and Pediatric Allergy, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.|GRIAC Research Institute, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
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Dubois
D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D005502:Food / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D008297:Male; D015995:Prevalence; D011379:Prognosis; D012720:Severity of Illness Index; D063189:Symptom Assessment; D013997:Time Factors
D000485:Allergens; D007073:Immunoglobulin E
adolescents; children; double-blind placebo controlled food challenge; food allergy; late reactions