Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements.
Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation.
Departments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Diana C
DC
Cox
Departments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: tcooper@bcm.edu.
Thomas A
TA
Cooper
D001259:Ataxia; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome; D006801:Humans; D014202:Tremor
D051860:Fragile X Messenger Ribonucleoprotein 1