Engineering of Adult Neurogenesis and Gliogenesis.
Neural stem/progenitor cells (NSPCs) retain their ability to generate newborn neurons throughout life in the mammalian brain. Here, we describe how recently developed virus- and transgenesis-based techniques will help us (1) to understand the functional effects of neurogenesis in health and disease, (2) to design novel approaches to harness the potential for NSPC-associated endogenous repair, and (3) to induce the generation of neurons outside the main neurogenic niches in the adult brain.
Adult Neurogenesis and Cellular Reprogramming, Institute of Physiological Chemistry & Focus Program Translational Neuroscience, University Medical Center, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
Benedikt
B
Berninger
Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
Sebastian
S
Jessberger
D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D051379:Mice; D058953:Neural Stem Cells / Q000166:cytology*; D055495:Neurogenesis / Q000235:genetics*