Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their bioproperties.
Three mononuclear Cu(II) complexes [Cu(naph-phe)phen] (1), [Cu(naph-tyr)(phen)] (2) and [Cu(naph-trp)(phen)] (3) were synthesized, characterized and their biological properties were studied. Complexes 1, 2, 3 exhibit square pyramidal geometry where Schiff base acts as a binegative tridentate ONO donor ligand and phen acts as NN donor ligand. CT-DNA binding studies revealed that the complexes bind through intercalative mode and show good binding propensity. The hydrolytic DNA cleavage activity of these complexes has been studied using gel electrophoresis. The DNA binding and cleavage affinities decrease in the order of 3>2>1. The in-vitro antimicrobial activities of the complexes were also studied.
Department of Chemistry, Osmania University, Hyderabad, 500 007, India. Electronic address: profprreddy@gmail.com.
Pulimamidi Rabindra
PR
Reddy
Department of Chemistry, Osmania University, Hyderabad, 500 007, India.
Suryam
S
Rajeshwar
Department of Chemistry, Osmania University, Hyderabad, 500 007, India.
Battu
B
Satyanarayana
D001667:Binding, Competitive / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D004587:Electrophoresis, Agar Gel; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010618:Phenanthrolines / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry; D014783:Viscosity
D056831:Coordination Complexes; D007364:Intercalating Agents; D010618:Phenanthrolines; D012545:Schiff Bases; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; C025205:1,10-phenanthroline
Cu(II) Schiff bases; DNA binding, cleavage and antibacterial studies