Association between HLA-A1 and -A2 types and Epstein-Barr virus status of post-transplant lymphoproliferative disorder.
The susceptibility to Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder (PTLD) may be affected by the human leukocyte antigen (HLA) type. We investigated HLA-A and HLA-B allele frequencies, focusing on HLA-A1 and -A2, in a population-based case series of EBV + (n = 60) and EBV- (n = 44) PTLD after solid organ transplantation. The proportion of EBV + PTLD was highest in HLA-A1 homozygotes (100%), lower in carriers of HLA-A1/AX (79%), HLA-A1/A2 (55%), HLA-A2/AX (54%), and lowest in HLA-A2 homozygotes (37%). HLA-A1 type was overrepresented (22% versus 7%, p = 0.05) and HLA-A2 type underrepresented (57% versus 80%, p = 0.01) in patients with EBV + compared with EBV - PTLD. EBV + PTLD in HLA-A1 carriers developed almost exclusively in already EBV-seropositive individuals. EBV status of PTLD was not related to any other HLA-A or HLA-B type. Our findings suggest that HLA-A1 carriers may have an increased risk of EBV + PTLD due to a decreased ability to control the latent EBV infection.
a Department of Medical Sciences, Section of Infectious Diseases , Uppsala University , Uppsala , Sweden ;
Amelie
A
Kinch
b Department of Immunology, Genetics and Pathology, Pathology , Uppsala University , Uppsala , Sweden ;
Christer
C
Sundström
c Department of Surgical Sciences , Uppsala University , Uppsala , Sweden ;
Gunnar
G
Tufveson
d Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology , Uppsala University , Uppsala , Sweden.
Ingrid
I
Glimelius
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D005838:Genotype; D015788:HLA-A1 Antigen / Q000235:genetics* / Q000276:immunology; D015789:HLA-A2 Antigen / Q000235:genetics* / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D010641:Phenotype; D011159:Population Surveillance; D011379:Prognosis; D012042:Registries; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
D015788:HLA-A1 Antigen; D015789:HLA-A2 Antigen
Epstein–Barr virus; HLA type; PTLD; lymphoma; solid organ transplantation