[Lymphopoiesis supported by osteolineage cells].
Bone marrow(BM)and thymus are known as the primary lymphoid organs for B and T cells, respectively. However, the cell fate for T cell lineage commitment is already determined in the BM. Thus, the lymphopoiesis is critically controlled in the BM and, according to the recent advances in genetic mouse models, it appears that this process is strictly regulated by a series of osteolineage mesenchymal populations.
Hematology, Department of Medicine, Kobe University Hospital, Japan.
Yoshio
Y
Katayama
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology*; D006410:Hematopoiesis / Q000276:immunology / Q000502:physiology*; D006801:Humans; D038041:Lymphopoiesis / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology*