Effect of dexmedetomidine added to ropivacaine on ultrasound-guided transversus abdominis plane block for postoperative analgesia after abdominal hysterectomy surgery: a prospective randomized controlled trial.
To identify the effect of dexmedetomidine added to ropivacaine on ultrasound-guided transversus abdominis plane block for postoperative analgesia after abdominal hysterectomy surgery.



Sixty patients were enrolled in the study and divided into two groups. Bilateral 20 mL 0.3% ropivacaine and 2 mL 0.9% normal saline for ropivacaine group (group R), and bilateral 20 mL 0.3% ropivacaine and 2 mL dexmedetomidine (0.5 µg/kg) for dexmedetomidine group (group RD). Visual Analogue Scale (VAS) pain scores, frequency of PCA pressed, sufentanil consumption, and postoperative nausea and vomiting (PONV) were recorded.



There was no significant difference in VAS pain scores between the two groups at different time intervals (P>0.05). Compared with group RD, the frequency of PCA pressed and integrated consumption of sufentanil were significantly higher in Group R at 0-2, 2-4, 4-6, 6-8, time intervals (P<0.05) except for 8-12,12-24 time intervals (P>0.05), and the 24h total sufentanil consumption and frequency of PCA pressed were also higher in group R (63.9±10.0 vs. 51.8±9.1, 8.3±1.7 vs. 5.4±1.6) (P<0.05). There was no difference in PONV between the two groups (P>0.05).



Ultrasound-guided TAP block could be as an effective component of multimodal postoperative analgesic regimen; adding dexmedetomidine to ropivacaine in TAP block potentiated the analgesic properties of ropivacaine, reduced sufentanil consumption and provided better pain control after abdominal hysterectomy surgery.
Department of Anesthesiology, The First People's Hospital of Lianyungang City, 182 Tongguan Road, Lianyungang, China - lygzhaozb@126.com.
Hengfei
H
Luan
Xiaobao
X
Zhang
Jiying
J
Feng
Pin
P
Zhu
Jiatie
J
Li
Zhibin
Z
Zhao
D000009:Abdominal Muscles / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000293:injuries; D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D000698:Analgesia / Q000379:methods; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D000077212:Ropivacaine; D018084:Ultrasonography, Interventional
D000577:Amides; D018712:Analgesics, Non-Narcotic; D000779:Anesthetics, Local; D020927:Dexmedetomidine; D000077212:Ropivacaine