Total Synthesis of Sarcophytonolide H and Isosarcophytonolide D: Structural Revision of Isosarcophytonolide D and Structure-Antifouling Activity Relationship of Sarcophytonolide H.
The first total syntheses of sarcophytonolide H and the originally proposed and correct structures of isosarcophytonolide D have been achieved via transannular ring-closing metathesis (RCM). These total syntheses culminated in the stereostructural confirmation of sarcophytonolide H and the reassignment of isosarcophytonolide D, respectively. The antifouling activity of the synthetic sarcophytonolide H and its analogues was also evaluated.
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University , 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
Hiroyoshi
H
Takamura
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University , 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
Takahiro
T
Kikuchi
Himeji EcoTech Co., Ltd., 841-49 Koh, Shirahama-cho, Himeji 672-8023, Japan.
Noriyuki
N
Endo
Himeji EcoTech Co., Ltd., 841-49 Koh, Shirahama-cho, Himeji 672-8023, Japan.
Yuji
Y
Fukuda
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University , 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
Isao
I
Kadota