Lewis Acid and Fluoroalcohol Mediated Nucleophilic Addition to the C2 Position of Indoles.
Indole readily undergoes nucleophilic substitution at the C3 site, and many indole derivatives have been functionalized using this property. Indole also forms indolium, which allows electrophilic addition in acidic conditions, but current examples have been limited to intramolecular reactions. C2 site-selective nucleophilic addition to indole derivatives using fluoroalcohol and a Lewis acid was developed.
Naoki
N
Morimoto
Kumika
K
Morioku
Hideyuki
H
Suzuki
Yasuo
Y
Takeuchi
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency , 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
Yuta
Y
Nishina