Longitudinal profiles of serum specific IgE and IgG4 to Dermatophagoides pteronyssinus allergen and its major components during allergen immunotherapy in a cohort of southern Chinese children.
Longitudinal data on serum specific sIgE and sIgG4 to allergen component of Dermatophagoides pteronyssinus (Der p) during allergen immunotherapy (AIT) are limited in Chinese populations. We serially followed up serum sIgE and sIgG4 to Der p and its components (Der p 1 and 2) in 51 Der p-sensitized children receiving guideline-based medications alone and additional 36-month AIT. The the Der p 1 and Der p 2 sIgE levels were elevated at 6 months and progressively declined from 12 months; the sIgG4 levels for Der p, Der p 1 and Der p 2 were increasing during the first year and reached a plateau thereafter; the sIgE/sIgG4 ratios for Der p 1 and Der p 2 decreased continuously from 6 through 24 months of AIT. Subgroup analysis showed that younger children (≤8years) experienced a greater increase in sIgG4 levels for Der p, Der p 1 and Der p 2 during AIT compared with older children (9-16 years). In summary, sIgE and sIgG4 to Der p 1 and Der p 2 may be more useful than those to Der p in reflecting the change in immunological reactivity during AIT. Earlier delivery of AIT may yield greater increase in sIgG4 after 36-month treatment than given later in life.
State Key Laboratory of Respiratory Disease, Guangzhou 510120, Guangdong, China; National Clinical Research Center for Respiratory Disease, Guangzhou 510120, Guangdong, China; Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, Guangdong, China; First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China; Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Guangqiao
G
Zeng
State Key Laboratory of Respiratory Disease, Guangzhou 510120, Guangdong, China; National Clinical Research Center for Respiratory Disease, Guangzhou 510120, Guangdong, China; Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, Guangdong, China; First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China; Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Peiyan
P
Zheng
State Key Laboratory of Respiratory Disease, Guangzhou 510120, Guangdong, China; National Clinical Research Center for Respiratory Disease, Guangzhou 510120, Guangdong, China; Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, Guangdong, China; First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China; Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Wenting
W
Luo
State Key Laboratory of Respiratory Disease, Guangzhou 510120, Guangdong, China; National Clinical Research Center for Respiratory Disease, Guangzhou 510120, Guangdong, China; Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, Guangdong, China; First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China; Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Huimin
H
Huang
State Key Laboratory of Respiratory Disease, Guangzhou 510120, Guangdong, China; National Clinical Research Center for Respiratory Disease, Guangzhou 510120, Guangdong, China; Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, Guangdong, China; First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China; Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Nili
N
Wei
State Key Laboratory of Respiratory Disease, Guangzhou 510120, Guangdong, China; National Clinical Research Center for Respiratory Disease, Guangzhou 510120, Guangdong, China; Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, Guangdong, China; First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China; Guangzhou Medical University, Guangzhou 510120, Guangdong, China. Electronic address: sunbaoqing@vip.163.com.
Baoqing
B
Sun
D000293:Adolescent; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology; D060829:Arthropod Proteins / Q000276:immunology; D044466:Asian People; D002648:Child; D003546:Cysteine Endopeptidases / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D008137:Longitudinal Studies; D008297:Male
D039741:Antigens, Dermatophagoides; D060829:Arthropod Proteins; C451163:Dermatophagoides pteronyssinus antigen p 2; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D003546:Cysteine Endopeptidases; C451162:Dermatophagoides pteronyssinus antigen p 1
Allergen components; Allergen immunotherapy; Dermatophagoides pteronyssinus; House dust mite; Specific IgE; Specific IgG4