Glutathione - From antioxidant to post-translational modifier.
Helmut Sies is one of the leading investigators in the multiple roles of glutathione (GSH) in biology. He has pioneered work on the role of GSH in preventing oxidative stress, in transport of GSSG, in protection of protein thiols from irreversible oxidation through mixed disulfide formation and demonstrated a role of protein glutathionylation in response to hormonal stimulation well before redox signaling became a major subject of investigation. Here I will describe the roles of GSH in several aspects of biology, the work of my laboratory in those findings, and how Helmut Sies work influenced our studies.
Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, The University of Southern California, USA. Electronic address: peroxideman@gmail.com.
Henry Jay
HJ
Forman
D000975:Antioxidants / Q000378:metabolism*; D001692:Biological Transport; D005978:Glutathione / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
D000975:Antioxidants; D005978:Glutathione
Glutathione; Protein mixed disulfide; Redox signaling; Scavenger pathway; γ-glutamylcysteine ligase