Serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios as an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men.
OBJECTIVE
Several studies have reported the association between sleep apnea syndrome and insulin resistance. Being overweight is known risk factor both for sleep apnea syndrome and insulin resistance. However, no studies have reported on the association between serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios (a marker of insulin resistance) and sleep apnea syndrome accounting for body mass index (BMI) status.


METHODS
Subjects for the present cross-sectional study consisted of 1,528 men aged 30-69 years undergoing pulse oximetry at a sleep disorders clinic for sleep apnea syndrome. Sleep apnea syndrome was diagnosed as a 3 % oxygen desaturation index (ODI) of ≥15 events/h.


RESULTS
Among study participants, 241 men were diagnosed with sleep apnea syndrome. Independent of classical cardiovascular risk factors, TG-HDL was significantly positively associated with sleep apnea syndrome in participants with a BMI <25 kg/m2, but not in participants with a BMI ≥25 kg/m2. The multivariable adjusted odds ratio (OR) and 95 % confidence interval (95 % CI) of sleep apnea syndrome per Log TG-HDL was 2.03 (95 % CI: 1.36-3.03) for a BMI <25 kg/m2and 1.23 (95 % CI: 0.89-1.70) for a BMI ≥25 kg/m2.


CONCLUSIONS
An independent positive association between TG-HDL levels and risk of sleep apnea syndrome was observed in participants with a BMI of <25 kg/m2, but not in participants with a BMI ≥25 kg/m2. TG-HDL levels could be an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men.
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan. simizicyuu@yahoo.co.jp.
Yuji
Y
Shimizu
Department of Respiratory Medicine, Inoue Hospital, Nagasaki, Japan.
Hiroyuki
H
Yoshimine
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Mako
M
Nagayoshi
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Koichiro
K
Kadota
Department of Respiratory Medicine, Inoue Hospital, Nagasaki, Japan.
Kensuke
K
Takahashi
Shunkaikai, Inoue Hospital, Nagasaki, Japan.
Kiyohiro
K
Izumino
Shunkaikai, Inoue Hospital, Nagasaki, Japan.
Kenichiro
K
Inoue
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.|Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Takahiro
T
Maeda
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D006801:Humans; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000453:epidemiology* / Q000209:etiology; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D014280:Triglycerides
HDL-cholesterol; Non-overweight; Sleep apnea syndrome; Triglycerides