Getting the Skinny on CD4(+) T Cell Survival in Fatty Livers.
Non-alcoholic fatty liver disease is associated with hepatocellular carcinoma. In the March 10 issue of Nature, Greten and colleagues report that this metabolic disruption affects tumor surveillance by depleting CD4+ T helper cells through lipotoxic mechanisms associated with NAFLD.
Center for Vaccines and Immunity, Nationwide Children's Hospital and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH 43205, USA. Electronic address: christopher.walker@nationwidechildrens.org.
Christopher M
CM
Walker
Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, Department of Medicine and Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517-7292, USA.
Stanley M
SM
Lemon
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D002470:Cell Survival / Q000276:immunology*; D006801:Humans; D007157:Immunologic Surveillance / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology*; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*