Beyond and behind the fingerprints of oxidative stress in age-related diseases: Secrets of successful aging.
Several years after the first publication of the definition of oxidative stress by Helmut Sies, this topic is still focus of a large body of attention and research in the field of aging, neurodegeneration and disease prevention. The conduction of clinical and epidemiological research without a solid biochemical rationale has led to largely frustrating results without being able to disprove the oxidative stress hypothesis. The present work is dedicated to Helmut Sies and describes the successful scientific approach to bench-to-bedside (-to-behavior) oxidative stress clinical research.
Ageing Clinical Research, Dpt. II Internal Medicine, University Hospital of Cologne, Cologne, Germany. Electronic address: maria.polidori-nelles@uk-koeln.de.
M Cristina
MC
Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Marlies
M
Scholtes
D000375:Aging / Q000378:metabolism*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism; D018384:Oxidative Stress