Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour.
OBJECTIVE
To investigate the immunohistochemical localization of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) in archival specimens of sporadic schwannoma.


METHODS
This study retrospectively analysed the immunolocalization of IGF-1 and IGF-1R in schwannoma specimens collected from all patients with sporadic schwannoma that were treated by two institutions in Japan. The study also evaluated the association between the extent of the IGF-1 and IGF-1R immunoreactivity and several clinicopathological characteristics (age, sex and maximum tumour dimension).


RESULTS
The study examined a total of 29 sporadic schwannoma specimens. IGF-1 and IGF-1R immunoreactivity was detected in the majority of the specimens regardless of their anatomical location. IGF-1 and IGF-1R were not co-localized. There was no association between the extent of the IGF-1 and IGF-1R immunoreactivity and the clinicopathological characteristics of the patients.


CONCLUSIONS
As IGF-1 and IGF-1R immunoreactivity was detected in the majority of sporadic schwannoma specimens regardless of their anatomical location, these findings suggest that an IGF-1/IGF-1R loop could play a role in the tumorigenesis and progression of schwannomas via an autocrine-paracrine mechanism.
Department of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Fumiaki
F
Matsubara
Department of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan t2kataba@marianna-u.ac.jp.
Takuyuki
T
Katabami
Department of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan.
Shiko
S
Asai
Department of Pathology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Yasushi
Y
Ariizumi
Department of Pathology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Ichiro
I
Maeda
Department of Pathology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Masayuki
M
Takagi
Department of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
May McNamara
MM
Keely
Department of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Katsuhiko
K
Ono
Department of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Takashi
T
Maekawa
Department of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Yasuhiro
Y
Nakamura
Department of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Yasushi
Y
Tanaka
Department of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Hironobu
H
Sasano
D003710:Demography; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000378:metabolism* / Q000473:pathology; D009442:Neurilemmoma / Q000378:metabolism* / Q000473:pathology; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D012186:Retroperitoneal Neoplasms / Q000378:metabolism / Q000473:pathology
D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1
Schwannoma; autocrine–paracrine loop; immunostaining; insulin-like growth factor 1; insulin-like growth factor 1 receptor; peripheral nerve sheath tumour