Topologically-associating domains: gene warehouses adapted to serve transcriptional regulation.
Structural-functional domains have long been hypothesized to occur in eukaryotic chromosomes, but their existence still remains controversial. Here, we discuss the current state of studies of 3D genome folding and the relation of this folding to the functional organization of the genome.
a Institute of Gene Biology, RAS , Moscow , Russia.|b Biological Faculty, Lomonosov Moscow State University , Moscow , Russia.|c LIA1066 "Laboratoire Franco-Russe de Recherche en Oncologie," Villejuif, France - Moscow , Russia.
Sergey V
SV
Razin
a Institute of Gene Biology, RAS , Moscow , Russia.
Alexey A
AA
Gavrilov
b Biological Faculty, Lomonosov Moscow State University , Moscow , Russia.|c LIA1066 "Laboratoire Franco-Russe de Recherche en Oncologie," Villejuif, France - Moscow , Russia.|d UMR8126, Université Paris-Sud, Institut de Cancérologie Gustave Roussy , Villejuif , France.
Yegor S
YS
Vassetzky
a Institute of Gene Biology, RAS , Moscow , Russia.|b Biological Faculty, Lomonosov Moscow State University , Moscow , Russia.
Sergey V
SV
Ulianov
D002875:Chromosomes / Q000737:chemistry* / Q000235:genetics; D005786:Gene Expression Regulation; D016678:Genome; D009690:Nucleic Acid Conformation; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic
3D genome organization; Hi-C; chromatin; functional genomic domains; topologically-associating domains