Nasal Mucosal Expression of the Receptors for Inflammatory Chemical Mediators.
The nasal allergic response is a complex process involving interactions between many chemical mediators such as histamine, bradykinin, cysteinyl leukotrienes, platelet-activating factor, prostaglandin D2 and thromboxane A2. The actions of these chemical mediators are facilitated by specific cell surface receptors that are coupled to G-proteins. Current therapeutic strategies against nasal allergic responses are mainly based on drugs that target these chemical mediators. To understand the role of these chemical mediators in allergic rhinitis, determining the identity and distribution of their receptors is of considerable interest. We have examined the expression and localization of the receptors for these chemical mediators in human nasal mucosa. Here, we review our data on the expression and localization of these receptors in allergic rhinitis, and we discuss the roles of chemical mediators in allergic rhinitis.
Hideaki
H
Shirasaki
Etsuko
E
Saikawa
Nobuhiko
N
Seki
Megumi
M
Kikuchi
Tetsuo
T
Himi
D000818:Animals; D003545:Cysteine / Q000096:biosynthesis*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D015289:Leukotrienes / Q000096:biosynthesis*; D009297:Nasal Mucosa / Q000378:metabolism*; D065631:Rhinitis, Allergic / Q000276:immunology / Q000378:metabolism*
D018836:Inflammation Mediators; D015289:Leukotrienes; C112381:cysteinyl-leukotriene; D003545:Cysteine