Mesonephric (Wolffian) Pseudoendometrioid Carcinoma of the Broad Ligament, Arising From a Papillary Cystadenoma.
This article describes the case of a 70-year-old woman with an adnexal cystadenocarcinoma located in the right broad ligament and displaying a striking resemblance to a well-differentiated endometrioid adenocarcinoma. The uniqueness of this pseudoendometrioid carcinoma lies in the fact that its mesonephric nature is revealed by the origin from a papillary cystadenoma of the broad ligament, where remnants of the mesonephric duct are seated, and the immunohistochemical profile, particularly a uniform negativity for estrogen and progesterone receptors, apical-luminal positivity for CD10, and strong nuclear positivity for GATA3.
Department of Pathology, Catholic University of Leuven, Leuven, Belgium philippe.moerman@uzleuven.be.
Philippe
P
Moerman
Department of Gynecologic Oncology and Leuven Cancer Institute, Catholic University of Leuven, Leuven, Belgium.
Frederic
F
Amant
Department of Gynecologic Oncology and Leuven Cancer Institute, Catholic University of Leuven, Leuven, Belgium.
Ignace
I
Vergote
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001956:Broad Ligament / Q000473:pathology*; D018269:Carcinoma, Endometrioid / Q000175:diagnosis; D003536:Cystadenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D018292:Cystadenoma, Papillary / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry
D014408:Biomarkers, Tumor
broad ligament; mesonephric carcinoma; papillary cystadenoma; pseudoendometrioid carcinoma