Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries.
OBJECTIVE
The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas.


METHODS
Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset.


RESULTS
Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis.


CONCLUSIONS
suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas.
a Intensive Care Unit, Korgialeneion Benakeion General Hospital , Athens , Greece ;
Maria
M
Patrani
b 4th Department of Internal Medicine , National and Kapodistrian University of Athens, Medical School , Athens , Greece ;
Thomas
T
Tsaganos
c Department of Surgery , Aristotle University of Thessaloniki, Faculty of Medicine, AHEPA Hospital , Thessaloniki , Greece.
Katerina
K
Kotzampassi
a Intensive Care Unit, Korgialeneion Benakeion General Hospital , Athens , Greece ;
Michael
M
Paraschos
a Intensive Care Unit, Korgialeneion Benakeion General Hospital , Athens , Greece ;
Chrysostomos
C
Katsenos
b 4th Department of Internal Medicine , National and Kapodistrian University of Athens, Medical School , Athens , Greece ;
Evangelos J
EJ
Giamarellos-Bourboulis
a Intensive Care Unit, Korgialeneion Benakeion General Hospital , Athens , Greece ;
Konstantinos
K
Mandragos
D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D009102:Multiple Organ Failure / Q000175:diagnosis* / Q000209:etiology; D009104:Multiple Trauma / Q000150:complications*; D016017:Odds Ratio; D020033:Protein Isoforms / Q000097:blood; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*; D018805:Sepsis / Q000175:diagnosis* / Q000209:etiology
D015415:Biomarkers; D020033:Protein Isoforms; D055293:Receptors, Urokinase Plasminogen Activator
Multiple organ failure; severe sepsis; suPAR; trauma