Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: a case report.
BACKGROUND
Osteoradionecrosis (ORN) is a challenging complication in patients with postirradiated nasopharyngeal carcinoma (NPC). The aim of this study was to evaluate the usage of a nasoseptal flap (NSF) after endoscopic sequestrectomy to reconstruct resultant skull base defects for the treatment of ORN.


METHODS
We present our experience on the adaption of an NSF as a reconstruction method for bony clival defects after endoscopic sequestrectomy in patients with postirradiated NPC. We propose that by which the patient may be offered better and prompt surgical results in the more adequate coverage of a vascularized flap for the exposed defect and attenuate the hypoxic and inflammatory process among the NPC patients suffering from postirradiation ORN.


CONCLUSIONS
To our knowledge, NSF use in such an indication has not been previously reported. Consequently, we advocate its utility for the management of patients with postirradiated skull base ORN in NPC in the future.
Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, No. 5, Fu-Hsing Street, Kwei-Shan, Tao-Yuan, 33305, Taiwan.|Department of Surgery, Al-Azhar University Hospitals in Cairo, Cairo, Egypt.
Mohamad
M
Adel
Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, No. 5, Fu-Hsing Street, Kwei-Shan, Tao-Yuan, 33305, Taiwan. dr.kpchang@gmail.com.|College of Medicine, Chang Gung University, 259 Wen-Hua 1st Road, Kwei-Shan, Tao-Yuan, 33302, Taiwan. dr.kpchang@gmail.com.
Kai-Ping
KP
Chang
D000368:Aged; D002277:Carcinoma; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000637:transplantation*; D009300:Nasal Septum / Q000637:transplantation*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D010025:Osteoradionecrosis / Q000209:etiology / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D019291:Skull Base / Q000601:surgery*; D013524:Surgical Flaps
Nasopharyngeal carcinoma; Nasoseptal flap; Osteoradionecrosis; Radiotherapy; Skull base reconstruction