Hemodynamic Performance and Thrombogenic Properties of a Superhydrophobic Bileaflet Mechanical Heart Valve.
In this study, we explore how blood-material interactions and hemodynamics are impacted by rendering a clinical quality 25 mm St. Jude Medical Bileaflet mechanical heart valve (BMHV) superhydrophobic (SH) with the aim of reducing thrombo-embolic complications associated with BMHVs. Basic cell adhesion is evaluated to assess blood-material interactions, while hemodynamic performance is analyzed with and without the SH coating. Results show that a SH coating with a receding contact angle (CA) of 160° strikingly eliminates platelet and leukocyte adhesion to the surface. Alternatively, many platelets attach to and activate on pyrolytic carbon (receding CA = 47), the base material for BMHVs. We further show that the performance index increases by 2.5% for coated valve relative to an uncoated valve, with a maximum possible improved performance of 5%. Both valves exhibit instantaneous shear stress below 10 N/m2and Reynolds Shear Stress below 100 N/m2. Therefore, a SH BMHV has the potential to relax the requirement for antiplatelet and anticoagulant drug regimens typically required for patients receiving MHVs by minimizing blood-material interactions, while having a minimal impact on hemodynamics. We show for the first time that SH-coated surfaces may be a promising direction to minimize thrombotic complications in complex devices such as heart valves.
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.|School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
David L
DL
Bark
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Hamed
H
Vahabi
School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
Hieu
H
Bui
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Sanli
S
Movafaghi
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Brandon
B
Moore
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.|School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
Arun K
AK
Kota
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.|School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
Ketul
K
Popat
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA. dasi.1@osu.edu.|School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA. dasi.1@osu.edu.|Department of Biomedical Engineering, Dorothy Davis Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH, 43210, USA. dasi.1@osu.edu.
Lakshmi P
LP
Dasi
D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D002448:Cell Adhesion; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006439:Hemodynamics; D006801:Humans; D007962:Leukocytes / Q000378:metabolism* / Q000473:pathology; D008422:Materials Testing; D033081:Shear Strength; D013927:Thrombosis / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology
Bileaflet mechanical heart valve; Blood; Shear stress; Superhydrophobic; Thrombosis; Turbulence