Toxicity Thresholds for Diclofenac, Acetaminophen and Ibuprofen in the Water Flea Daphnia magna.
Non-steroid anti-inflammatory drugs (NSAIDs) have been frequently detected in aquatic ecosystem and posed a huge risk to non-target organisms. The aim of this study was to evaluate the toxic effects of three typical NSAIDs, diclofenac (DFC), acetaminophen (APAP) and ibuprofen (IBP), toward the water flea Daphnia magna. All three NSAIDs showed remarkable time-dependent and concentration-dependent effects on D. magna, with DFC the highest and APAP the lowest toxic. Survival, growth and reproduction data of D. magna from all bioassays were used to determine the LC10 and LC50 (10 % lethal and median lethal concentrations) values of NSAIDs, as well as the EC10 and EC50 (10 % effect and median effect concentrations) values. Concentrations for the lethal and sublethal toxicity endpoints were mainly in the low ppm-range, of which reproduction was the most sensitive one, indicating that non-target organisms might be adversely affected by relevant ambient low-level concentrations of NSAIDs after long-time exposures.
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.|State Key Laboratory of Applied Microbiology Southern China, Guangzhou, China.
Juan
J
Du
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.|State Key Laboratory of Applied Microbiology Southern China, Guangzhou, China.
Cheng-Fang
CF
Mei
Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China.
Guang-Guo
GG
Ying
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China. xumy@gdim.cn.|State Key Laboratory of Applied Microbiology Southern China, Guangzhou, China. xumy@gdim.cn.
Mei-Ying
MY
Xu
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D003621:Daphnia / Q000187:drug effects* / Q000254:growth & development; D004008:Diclofenac / Q000633:toxicity*; D007052:Ibuprofen / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014874:Water Pollutants, Chemical; D004008:Diclofenac; D000082:Acetaminophen; D007052:Ibuprofen
Acute toxicity; Chronic toxicity; Daphnia magna; Non-steroid anti-inflammatory drugs; Toxicity threshold