Effect of Frequency-Dependent Attenuation on Predicted Histotripsy Waveforms in Tissue-Mimicking Phantoms.
Tissue-mimicking phantoms are employed for the assessment of shocked histotripsy pulses in vitro. These broadband shock waves are critical for tissue ablation and are influenced by the frequency-dependent attenuation of the medium. The density, sound speed and attenuation spectra (2-25 MHz) were measured for phantoms that mimic key histotripsy targets. The influence of non-linear propagation relative to the attenuation was described in terms of Gol'dberg number. An expression was derived to estimate the bandwidth of shocked histotripsy pulses for power law-dependent attenuation. The expression is independent of the fundamental frequency of the histotripsy pulse for linear frequency-dependent attenuation.
Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Kenneth B
KB
Bader
Biomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio, USA.
Michael J
MJ
Crowe
Biomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio, USA.
Jason L
JL
Raymond
Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA; Biomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio, USA. Electronic address: christy.holland@uc.edu.
Christy K
CK
Holland
D004867:Equipment Design; D008954:Models, Biological; D019047:Phantoms, Imaging; D059708:Ultrasonic Surgical Procedures / Q000379:methods*
Acoustical properties; Cavitation; Histotripsy; Shock waves; Ultrasonic attenuation