Mild access to planar-chiral ortho-condensed aromatic ferrocenes via gold(i)-catalyzed cycloisomerization of ortho-alkynylaryl ferrocenes.
An efficient approach to (Rp) planar-chiral tri- and tetracyclic ortho-condensed aromatic ferrocenes was developed through the enantioselective cationic Au(i)-catalyzed cycloisomerization, in the presence of bidentate phosphine ligand (R)-DTBM-Segphos, from readily available ortho-alkynylaryl ferrocenes under very mild conditions (11 examples, up to 92% yield and 93% ee).
Departamento de Química Orgánica (Módulo 01), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid, Spain. antonio.urbano@uam.es carmen.carrenno@uam.es.
Antonio
A
Urbano
Gloria
G
Hernández-Torres
Ana M
AM
Del Hoyo
Alicia
A
Martínez-Carrión
M
M
Carmen Carreño