Peste des Petits Ruminants Virus.
Peste des petits ruminants virus (PPRV) causes a severe contagious disease of sheep and goats and has spread extensively through the developing world. Because of its disproportionately large impact on the livelihoods of low-income livestock keepers, and the availability of effective vaccines and good diagnostics, the virus is being targeted for global control and eventual eradication. In this review we examine the origin of the virus and its current distribution, and the factors that have led international organizations to conclude that it is eradicable. We also review recent progress in the molecular and cellular biology of the virus and consider areas where further research is required to support the efforts being made by national, regional, and international bodies to tackle this growing threat.
The Pirbright Institute, Surrey, United Kingdom. Electronic address: michael.baron@pirbright.ac.uk.
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Baron
CIRAD, UMR Contrôle des maladies animales exotiques et émergentes (CMAEE), Montpellier, France; INRA, UMR CMAEE 1309, Montpellier, France.
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Diallo
CIRAD, UMR Contrôle des maladies animales exotiques et émergentes (CMAEE), Montpellier, France; INRA, UMR CMAEE 1309, Montpellier, France.
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Lancelot
CIRAD, UMR Contrôle des maladies animales exotiques et émergentes (CMAEE), Montpellier, France; INRA, UMR CMAEE 1309, Montpellier, France.
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Libeau
D000349:Africa; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001208:Asia; D060740:Disease Eradication; D015967:Gene Expression Regulation, Viral; D006041:Goats; D058507:Host Specificity; D029021:Peste-des-Petits-Ruminants / Q000276:immunology / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D018107:Peste-des-petits-ruminants virus / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D010802:Phylogeny; D058974:Phylogeography; D012756:Sheep; D014613:Vaccines, Attenuated; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014764:Viral Proteins; D014765:Viral Vaccines
Eradication; Goats; Livestock; Morbillivirus; Rinderpest; Sheep