New depsidones and xanthone from the roots of Garcinia schomburgkiana.
Two new depsidones, schomburgdepsidones A and B (1 and 2), and one new xanthone, schomburgxanthone A (3), together with eight known compounds (4-11) were isolated from the roots of Garcinia schomburgkiana. Their chemical structures were established on the basis of spectroscopic analysis. The in vitro cytotoxicity of all 11 compounds was evaluated against the KB, HeLa S-3, HT-29, MCF-7 and Hep G2 human cancer cell lines. Compound 7 performed a good cytotoxicity against the KB, Hela S-3 and MCF-7 cell lines with IC50 values in the range of 3.17-6.07μM. Compound 3 exhibited a good cytotoxicity against the KB cell line only, with an IC50 value of 8.14μM.
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Edwin Risky
ER
Sukandar
Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
Pongpun
P
Siripong
Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand.
Suttira
S
Khumkratok
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: Santi.Ti@chula.ac.th.
Santi
S
Tip-Pyang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D053630:Depsides / Q000737:chemistry* / Q000302:isolation & purification; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D053630:Depsides; D007783:Lactones; D010936:Plant Extracts; D044004:Xanthones; C000613390:schomburgdepsidone A; C000613391:schomburgdepsidone B; C000613389:schomburgxanthone A; C000875:depsidone
Cytotoxicity; Depsidone; Garcinia schomburgkiana; Xanthone