Clinical Usefulness of Arbekacin.
Arbekacin is a broad-spectrum aminoglycoside used to treat methicillin-resistant Staphylococcus aureus (MRSA). Arbekacin has antibacterial activities against high-level gentamicin-resistant Enterococci, multidrug-resistant Pseudomonas aeruginosa, and Acinetobacter baumannii et al. Here, we reviewed in vitro data on arbekacin in Staphylococci and Gram-negative microorganisms. We also reviewed clinical studies for clinical efficacy and microbiologic efficacy data in patients with identified MRSA and suspected MRSA infections. The overall clinical efficacy ranged from 66.7% to 89.7%. The microbiologic efficacy rate ranged from 46.2% to 83%. In comparative studies between arbekacin and glycopeptides, arbekacin was similar to other glycopeptides with respect to clinical and microbiological efficacy rates. Combination trials with other antibiotics suggest that arbekacin will be a promising strategy to control Enterococcus spp. multi-drug resistant P. aeruginosa. The major adverse reaction was nephrotoxicity/hepatotoxicity, but patients recovered from most adverse reactions without any severe complications. Based on these results, arbekacin could be a good alternative to vancomycin/teicoplanin in MRSA treatment. Finally, therapeutic drug monitoring is recommended to maximize clinical efficacy and decrease nephrotoxicity.
Department of Internal Medicine, Wonkwang University Medical School, Iksan, Korea.
Jae Hoon
0000-0002-0897-2838
JH
Lee
Department of Internal Medicine, Chonbuk National University, Jeonju, Korea.; Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.; Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
Chang-Seop
0000-0002-2897-2202
CS
Lee
Alternative; Antibiotics; Arbekacin; Glycopeptides; Methicillin-resistant Staphylococcus aureus