A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain.
We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. However, her headache and brain lesion worsened. After the brain biopsy, the patient was confirmed with intracranial tuberculoma. Linezolid was added to intensify the treatment regimen, and steroid was added for the possibility of paradoxical response. Kanamycin was discontinued 6 months after initiation of the treatment; she was treated for 18 months with susceptible drugs and completely recovered. To our knowledge, this case is the first multidrug-resistant tuberculosis that disseminated to the brain in Korea.
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Eun Kyo
0000-0003-3662-1899
EK
Jung
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Ji Young
JY
Chang
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Yoon Pyo
YP
Lee
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Min Kyung
MK
Chung
Department of Neurological Surgery, Ewha Womans University School of Medicine, Seoul, Korea.
Eui Kyo
EK
Seo
Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea.
Hea Soo
HS
Koo
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Hee Jung
0000-0002-1468-4074
HJ
Choi
Mycobacterium tuberculosis; Tuberculosis, central nervous system; Tuberculosis, multidrug-resistant; Tuberculosis, pulmonary