Toxicodynetics: A new discipline in clinical toxicology.
OBJECTIVE
Regarding the different disciplines that encompass the pharmacology and the toxicology, none is specifically dedicated to the description and analysis of the time-course of relevant toxic effects both in experimental and clinical studies. The lack of a discipline devoted to this major field in toxicology results in misconception and even in errors by clinicians.


METHODS
Review of the basic different disciplines that encompass pharmacology toxicology and comparing with the description of the time-course of effects in conditions in which toxicological analysis was not performed or with limited analytical evidence.


RESULTS
Review of the literature clearly shows how misleading is the current extrapolation of toxicokinetic data to the description of the time-course of toxic effects.


CONCLUSIONS
A new discipline entitled toxicodynetics should be developed aiming at a more systematic description of the time-course of effects in acute human and experimental poisonings. Toxicodynetics might help emergency physicians in risk assessment when facing a poisoning and contribute to a better assessment of quality control of data collected by poison control centres. Toxicodynetics would also allow a quantitative approach to the clinical effects resulting from drug-drug interaction.
UMR-8257 Cognitive and Action Group, université Paris Descartes, 75006 Paris, France; Département d'anesthésie-réanimation, SAMU 75, réanimation adulte polyvalente, groupe hospitalier Necker, Assistance publique-Hôpitaux de Paris, 75015 Paris, France; Centre antipoison, hôpital Fernand-Widal, 75010 Paris, France; Université Paris Diderot, 75013 Paris, France. Electronic address: baud.frederic@wanadoo.fr.
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FJ
Baud
Laboratoire de chimie-toxicologie analytique et cellulaire (EA 4463), faculté de pharmacie, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
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Houzé
Centre antipoison, hôpital Fernand-Widal, 75010 Paris, France.
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Villa
Division of Medical Toxicology, Texas Tech University Health Sciences Center, 4801 Alberta Avenue, El Paso, TX 79905, USA.
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Borron
Département d'anesthésie-réanimation, SAMU 75, réanimation adulte polyvalente, groupe hospitalier Necker, Assistance publique-Hôpitaux de Paris, 75015 Paris, France.
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Carli
D062787:Drug Overdose / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D011039:Poison Control Centers; D018570:Risk Assessment; D013038:Specialization; D066007:Toxicokinetics; D014116:Toxicology / Q000639:trends*
Intoxication; Overdoses; Pharmacocinétiques; Pharmacodynamics; Pharmacodynamie; Pharmacokinetics; Poisonings; Surdose; Toxicocinétique; Toxicodynamics; Toxicodynamie; Toxicodynetics; Toxicodynétique; Toxicokinetics