EFFECT OF IRON SUPPLEMENT ON Hb SYNTHESIS BY IRON DEFICIENT RETICULOCYTES--AN IN VITRO STUDY.
Iron uptake for hemoglobin synthesis was apparently increased in the reticulocytes of severely iron deficient anemic women, but was actually decreased significantly when expressed in terms of number of reticulocytes. The decreased synthesis could be restored to more than normal by supplementing with ferric iron or transferrin iron (normal plasma), but not with ferrous iron, which rather further reduced the already impaired hemoglobin synthesis.
Department of Biochemistry, S.M.S. Medical College & Hospital, Jaipur - 302 004.
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Sharma
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Goyal
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Mathur
D019587:Dietary Supplements; D005260:Female; D006454:Hemoglobins / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000008:administration & dosage*; D000090463:Iron Deficiencies; D012156:Reticulocytes / Q000378:metabolism*
D006454:Hemoglobins; D007501:Iron