Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines.
A copper-catalyzed amino lactonization of unsaturated carboxylic acids has been achieved as well as the analogous intermolecular three-component amino oxygenation of olefins. The transformation features mild conditions and a remarkably broad substrate scope, offering a novel and efficient approach to construct a wide range of amino lactones as well as 1,2-amino alcohol derivatives. Mechanistic studies suggest that the reaction proceeds via a distinctive O-benzoylhydroxylamine-promoted electrophilic amination of alkenes.
Department of Chemistry, Duke University , Durham, North Carolina 27708, United States.
Brett N
BN
Hemric
Department of Chemistry, Duke University , Durham, North Carolina 27708, United States.
Kun
K
Shen
Department of Chemistry, Duke University , Durham, North Carolina 27708, United States.
Qiu
Q
Wang