Bacterial resistance to antimicrobial peptides: an evolving phenomenon.
Bacterial resistance to conventional antibiotics is currently a real problem all over the world, making novel antimicrobial compounds a real research priority. Some of the most promising compounds found to date are antimicrobial peptides (AMPs). The benefits of these drugs include their broad spectrum of activity that affects several microbial processes, making the emergence of resistance less likely. However, bacterial resistance to AMPs is an evolving phenomenon that compromises the therapeutic potential of these compounds. Therefore, it is mandatory to understand bacterial mechanisms of resistance to AMPs in depth, in order to develop more powerful AMPs that overcome the bacterial resistance response.
Pos-Graduacao da Faculdade de Medicina, Campus Universitario Darcy Ribeiro, Universidade de Brasilia, Asa Norte, Brasília, DF, Brazil and S-Inova, Programa de Pos-Graduacao em Biotecnologia, Universidade Catolica Dom Bosco, 79117-900 Campo Grande, MS, Br.
Osmel
O
Fleitas
S-Inova, Programa de Pos-Graduacao em Biotecnologia, Universidade Catolica Dom Bosco, 79117-900 Campo Grande, MS, Brazil and Department of Biochemistry, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast.
Caleb M
CM
Agbale
S-Inova, Programa de Pos-Graduacao em Biotecnologia, Universidade Catolica Dom Bosco, 79117-900 Campo Grande, MS, Brazil, ocfranco@gmail.com.
Octavio L
OL
Franco
D023181:Antimicrobial Cationic Peptides / Q000493:pharmacokinetics / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects / Q000235:genetics; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D015536:Down-Regulation; D015195:Drug Design; D024881:Drug Resistance, Bacterial / Q000235:genetics / Q000502:physiology; D006801:Humans; D009997:Osmotic Pressure; D055550:Protein Stability; D021381:Protein Transport; D059748:Proteolysis
D023181:Antimicrobial Cationic Peptides