Influence of vaccine strains on the evolution of canine distemper virus.
Canine distemper virus (CDV) is a major dog pathogen belonging to the genus Morbillivirus of the family Paramyxoviridae. CDV causes disease and high mortality in dogs and wild carnivores. Although homologous recombination has been demonstrated in many members of Paramyxoviridae, these events have rarely been reported for CDV. To detect potential recombination events, the complete CDV genomes available in GenBank up to June 2015 were screened using distinct algorithms to detect genetic conversions and incongruent phylogenies. Eight putative recombinant viruses derived from different CDV genotypes and different hosts were detected. The breakpoints of the recombinant strains were primarily located on fusion and hemagglutinin glycoproteins. These results suggest that homologous recombination is a frequent phenomenon in morbillivirus populations under natural replication, and CDV vaccine strains might play an important role in shaping the evolution of this virus.
Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Renata
R
da Fontoura Budaszewski
Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
André Felipe
AF
Streck
Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Matheus
M
Nunes Weber
Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, UFRGS, Porto Alegre, RS, Brazil.
Franciele
F
Maboni Siqueira
Laboratório de Bioinformática, Laboratório Nacional de Computação Científica (LNCC), Petrópolis, Rio de Janeiro, Brazil.
Rafael Lucas
RL
Muniz Guedes
Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: claudio.canal@ufrgs.br.
Cláudio
C
Wageck Canal
D000465:Algorithms; D000818:Animals; D004216:Distemper / Q000517:prevention & control / Q000821:virology; D004217:Distemper Virus, Canine / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D004285:Dogs; D019143:Evolution, Molecular; D016679:Genome, Viral / Q000235:genetics; D010802:Phylogeny; D011995:Recombination, Genetic; D014765:Viral Vaccines / Q000235:genetics*
D014765:Viral Vaccines
Canine distemper virus; Dog; Evolution; Phylogeny; Recombination