Single Gallstone Associated with High Fasting Insulin Level.
Gallstone (GS) formation is a multifactorial process and one of the associated factors is hyperinsulinemia. The aim of this cross-sectional study was to determine the association between size and count of gallstones, and insulin levels and resistance. The study group composed of 84 patients who have ultrasonographically confirmed gallstone(s). Insulin level of all participants were measured and insulin resistance was calculated with the homeostasis model assessment of insulin resistance (HOMA-IR) index. All p-values &amp;lt; 0.05 were considered statistically significant. There were 28 patients with single stone and 56 with multiple stones. Mean insulin level was 12.54 &amp;plusmn;11.66 ml/U (median 9.91 ml/U, IQR 6.33) and 56.3% of patients had insulin resistance. Mean stone size was 7.82 &amp;plusmn;7.52 mm (median 6 mm and IQR 11.75). There was a non-significant association and correlation between insulin level and size of GS (p=0.129; r =0.16). There was significant difference between single stone group and multiple stones group, according to the insulin level.
Department of Family Medicine, Dr. Lutfi Kirdar Kartal Education and Training Hospital, Istanbul, Turkey.
Can
C
Oner
Department of Internal Medicine, Bakirkoy Dr Sadi Konuk Education and Training Hospital, Division of Rheumatology, Istanbul, Turkey.
Sibel
S
Yilmaz-Oner
Department of Internal Medicine, Bezmialem University, School of Medicine, Istanbul, Turkey.
Ruhper
R
Cekin
Department of Internal Medicine, Cukurova University, School of Medicine, Adana, Turkey.
Mehmet Celalettin
MC
Guneri
Department of Family Medicine, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.
Mehmet
M
Sargin
D000328:Adult; D000368:Aged; D001786:Blood Glucose; D003430:Cross-Sectional Studies; D005260:Female; D042882:Gallstones / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D012307:Risk Factors; D014463:Ultrasonography
D001786:Blood Glucose; D007328:Insulin