"State-of-Art" paper of the Italian Working Group on Atherosclerosis: Preclinical assessment of early coronary atherosclerosis.
Although the early diagnosis and treatment for acute myocardial infarction have improved over the past decades, the morbidity and mortality from coronary artery disease (CAD) remain significant in Europe and worldwide. It is estimated that the majority of people in the developed countries who die suddenly from CAD, have no prior manifestation of disease, and the majority of these individuals are not considered to be at high risk. Accurate identification of individuals at risk of such events before the clinical manifestations is therefore required. This "State-of-Art" paper of the Italian Working Group on Atherosclerosis aims to i. provide an overview of both the traditional and emerging non-invasive imaging techniques used to detect early atherosclerosis in the general population with moderate cardiovascular risk; ii. identify the rationale for screening asymptomatic patients with preclinical atherosclerotic lesions and the optimal algorithm that should be used to detect them; iii. discuss the future directions of atherosclerosis research, with special focus on nanotechnology, aimed at early identification and treatment of low- and intermediate-risk patients.
Institute of Cardiology and Center of Excellence on Aging, "G. d'Annunzio" University, Chieti, Italy; The University of Texas Health Science Center at Houston, Houston, TX, USA; Texas Heart Institute, Houston, TX, USA. Electronic address: rmadonna@unich.it.
Rosalinda
R
Madonna
Geriatric Division, A.R.N.A.S. Ospedale "Garibaldi" Nesima, Catania, Italy.
Stefano
S
Selvaggio
Studio Medico Specialistico "VITTORIA", Vittoria, RG, Italy.
Giancarlo
G
Selvaggio
Department of InternaI Medicine and MedicaI Therapy, University of Pavia, Pavia, Italy; Interdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, Pavia, Italy.
Maurizio
M
Coronelli
Department "Cuore e Grossi Vasi Attilio Reale", "Sapienza" University, Policlinico Umberto I, Rome, Italy.
Nino
N
Cocco
D000465:Algorithms; D015415:Biomarkers / Q000378:metabolism*; D057791:Cardiac Imaging Techniques / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D042241:Early Diagnosis; D005080:Exercise Test; D006801:Humans; D007558:Italy; D036103:Nanotechnology; D012307:Risk Factors
D015415:Biomarkers
Biomarkers; Cardiac imaging; Nanotechnology; Preclinical atherosclerosis; Stress test; Vascular imaging