Severe pancytopenia due to acute folate deficiency despite normal folate erythrocyte level.
We report the case of an alcoholic patient with severe pancytopenia with low plasma folate level but normal erythrocyte folates and cobalamin levels. The bone marrow smear concluded to a pancytopenia due to folates and/or cobalamin deficiency. Severe pancytopenia due to acute plasma folate deficiency can be observed despite normal erythrocyte folates level which reflects the organism's folates store.
Service de médecine interne et des maladies infectieuses et tropicales, CHU Reims, France.
Antoine
A
Huguenin
Service de médecine interne et des maladies infectieuses et tropicales, CHU Reims, France.
Sara
S
Barraud
Laboratoire d'hématologie, CHU Reims, France.
Sylvie
S
Daliphard
Laboratoire central de biochimie, CHU Reims, France.
Didier
D
Marot
Laboratoire de biologie et de recherche pédiatriques, CHU Reims, France.
Roselyne
R
Garnotel
Service de médecine interne et des maladies infectieuses et tropicales, CHU Reims, France.
Firouzé
F
Bani-Sadr
D000208:Acute Disease; D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000150:complications; D004912:Erythrocytes / Q000737:chemistry*; D005492:Folic Acid / Q000032:analysis* / Q000097:blood; D005494:Folic Acid Deficiency / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D012720:Severity of Illness Index
D005492:Folic Acid
acute folate deficiency; alcohol-associated pancytopenia; alcohol-blood disorders; megaloblastic anemia; pancytopenia