Prediction of seizure incidence probability in PTZ model of kindling through spatial learning ability in male and female rats.
Epilepsy is a common neurological disease characterized by periodic seizures. Cognitive deficits and impairments in learning and memory are also associated with epilepsy. Neuronal changes and synaptic modifications in kindling model of epilepsy are similar to those occur during the learning procedure and memory formation. Herein we investigated whether seizure susceptibility in pentylenetetrazol (PTZ) model of kindling is predictable based on the learning ability in the Morris water maze (MWM) task in male and female rats. Allocentric learning was tested using MWM in present of light while egocentric learning was evaluated by MWM in dark room. The results indicated no significant differences in allocentric learning abilities between male and female rats. However, male rats were able to memorize the location of the platform more effectively compared to females in egocentric test. In addition, a statistically significant negative correlation between learning abilities (working memory) and seizure susceptibility in male rats was found while this correlation was positive in female rats. On the other hand, although there was no significant correlation between retrieval (reference memory) of spatial memories and seizure parameters in male rats, female rats showed a significant negative correlation. These findings may provide some evidences for prediction of seizure susceptibility according to learning ability and memory retention.
Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR, Iran.
Narges-Al-Sadat
NA
Haeri
Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR, Iran. Electronic address: dr.palizvan@arakmu.ac.ir.
Mohammad Reza
MR
Palizvan
Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR, Iran.
Mehdi
M
Sadegh
Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR, Iran.
Zohre
Z
Aghaei
Department of Biostatistics, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR, Iran.
Mohammad
M
Rafiei
D000818:Animals; D003292:Convulsants / Q000633:toxicity*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D010433:Pentylenetetrazole / Q000633:toxicity*; D011237:Predictive Value of Tests; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D065853:Spatial Learning / Q000187:drug effects*; D013223:Statistics as Topic
D003292:Convulsants; D010433:Pentylenetetrazole
Allocentric learning; Egocentric learning; Epilepsy; Rat; Retrieval of memory; Spatial memory