Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats.
BACKGROUND
Nonsteroidal anti-inflammatory drugs (NSAIDs) induced organ damage is a well-known fact. Previous studies suggest that Lactobacillus scavenge the free radicals from liver and kidney and also protect animals from arthritis.


OBJECTIVE
Comparing protective properties of Lactobacillus acidophilus in reducing oxidative stress from reproductive organs developed during collagen-induced arthritis in animal model.


METHODS
Arthritis was induced in Wistar rats. Oral administration of L. acidophilus, indomethacin, and distilled water were all started on the same day. Arthritis scores were calculated for each group. Oxidative stress parameters were estimated in testis and ovary homogenates. Histopathology of ovary and testis was also performed.


CONCLUSIONS
L. acidophilus decreased arthritis score (P < 0.001) as well as maintained normal histology of reproductive organs. L. acidophilus maintained oxidative stress parameters from ovaries and testis (P < 0.001). These results provide strong evidence that NSAIDs increase oxidative stress in reproductive organs while L. acidophilus not only scavenges free radicals from reproductive organs but also protects rats from arthritis symptoms.
Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India.
Sarika
S
Amdekar
Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India.
Vinod
V
Singh
Collagen-induced arthritis; Lactobacillus acidophilus; cyclooxygenase; ovary; oxidative stress; probiotics; testis