[Alteration of white rats brain tissue inducted by assessment of silver nanocomposite incapsulated in polymer matrix].
The paper present experimental materials of intragastric administration of silver nanoparticles encapsulated in polymer matrix of arabinogalactan by white outbred male rats. Animals were injected "pure" arabinogalactan and colloid silver solution containing silver macroform separately for comparison. Research provided data about status of brain tissue at the impact of these substances on organism. Histological analysis revealed the presence of a pathological process, character and intensity of which varied depending on the type of injected material. Pathological process under the influence of silver-arabinogalactan characterized by appearance in brain tissue of perivascular edema and development of acute inflammation in formation of glial scars, swelling of vascular bundles in sum.
E A
EA
Titov
L M
LM
Sosedova
M A
MA
Novikov
D000818:Animals; D001929:Brain Edema / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology*; D005685:Galactans / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D053768:Metal Nanoparticles / Q000009:adverse effects*; D053761:Nanocomposites / Q000009:adverse effects*; D051381:Rats; D012834:Silver / Q000009:adverse effects* / Q000737:chemistry / Q000494:pharmacology; D066127:White Matter
D005685:Galactans; D012834:Silver; C005653:arabinogalactan