Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases.
There is an overwhelming need for a simple, reliable tool that aids clinicians in diagnosing, assessing disease activity and treating rheumatic conditions. Identification of biomarkers in partially understood inflammatory disorders has long been sought after as the Holy Grail of Rheumatology. Given the complex nature of inflammatory conditions, it has been difficult to earmark the potential biomarkers. Metabolomics, however, is promising in providing new insights into inflammatory conditions and also identifying such biomarkers. Metabolomic studies have generally revealed increased energy requirements for by-products of a hypoxic environment, leading to a characteristic metabolic fingerprint. Here, we discuss the significance of such studies and their potential as a biomarker.
Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address: jutley@doctors.org.uk.
Gurpreet Singh
GS
Jutley
Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address: s.p.young@bham.ac.uk.
Stephen P
SP
Young
D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D055432:Metabolomics; D012216:Rheumatic Diseases / Q000473:pathology*; D012219:Rheumatology
D015415:Biomarkers
Biomarkers; Inflammation; Metabolism; Metabolomics