Detection of pulmonary and coronary artery anomalies in tetralogy of Fallot using non-ECG-gated CT angiography.
OBJECTIVE
To evaluate the use of non-ECG-gated computed tomography (CT) angiography to describe pulmonary and coronary defects in patients with tetralogy of Fallot (TOF).


METHODS
This retrospective study was carried out on TOF patients having undergone pre-operative non-ECG-gated CT angiography between February 2007 and September 2012. The following clinical parameters were recorded: mean age at CT angiography, sex, the existence of genetic disease and the need to sedate the patient prior to CT angiography. CT data were analyzed retrospectively to determine the site(s) of pulmonary stenosis (infundibular, valvular or arterial), the size of pulmonary arteries and the presence of anomalous coronary artery courses. CT findings were then compared to the anatomy observed during surgery.


RESULTS
Thirty-five patients were included in the study. The mean age was 4.30±1.91months (boys/girls=17/18). Two patients had associated chromosome disorders (one 22q11 microdeletion and one CHARGE syndrome). Sixteen patients (45.71%) were sedated prior to CT. Pulmonary artery assessment revealed 24 patients (68.57%) with infundibular stenosis, 5 (17.5%) with infundibular and/or valvular stenosis, and 6 (21%) with anomalous pulmonary arteries. CT angiography also evidenced anomalous coronary arteries in 8 patients (22.85%).


CONCLUSIONS
Due to its reduced scanning time and high spatial resolution, non-ECG-gated CT angiography is a non-invasive imaging modality that provides accurate information on pulmonary and coronary artery anatomy in patients with TOF.
Department de pédiatrie, université de médicine et pharmacie "Iuliu Hatieganu", 3-5 Crisan rue, Cluj, Napoca, Romania.
A
A
Hrusca
Department de pédiatrie, université de médicine et pharmacie "Iuliu Hatieganu", 3-5 Crisan rue, Cluj, Napoca, Romania.
A L
AL
Rachisan
Department d'imagerie pédiatrique, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
P
P
Gach
Department d'imagerie pédiatrique, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
H
H
Pico
Department d'imagerie pédiatrique, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
C
C
Sorensen
Department de cardiologie, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
B
B
Bonello
Department de cardiologie, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
C
C
Ovaert
Department d'imagerie pédiatrique, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
P
P
Petit
Department de cardiologie, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
V
V
Fouilloux
Department de cardiologie, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
L
L
Mace
Department d'imagerie pédiatrique, hôpital de La Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address: guillaume.gorincour@ap-hm.fr.
G
G
Gorincour
D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D000072226:Computed Tomography Angiography / Q000379:methods*; D003330:Coronary Vessel Anomalies / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011300:Preoperative Care; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000601:surgery; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013771:Tetralogy of Fallot / Q000000981:diagnostic imaging* / Q000601:surgery
Computed tomography; Coronary artery; Pulmonary artery; Tetralogy of Fallot