Enhancer, epigenetics, and human disease.
Enhancers encode a huge body of information to determine the precise tissue specific gene expression pattern during normal development. Nowadays, enhancers are also considered as key players in directing disease transcriptional program during pathogenesis. New genomic technologies allow the identification, functional characterization and manipulation of enhancers. The advances in the transcriptional enhancer field hold great promise in linking developmental or disease phenotypes to genetic variants and promoting precision medicine.
Transcriptional Control in Development and Disease Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore.
Zhuojuan
Z
Luo
Transcriptional Control in Development and Disease Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Institute of Life Sciences, the Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China. Electronic address: cqlin@imcb.a-star.edu.sg.
Chengqi
C
Lin
D004742:Enhancer Elements, Genetic; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D030342:Genetic Diseases, Inborn; D023281:Genomics; D006801:Humans; D009928:Organ Specificity; D057285:Precision Medicine; D014158:Transcription, Genetic