Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/T polymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/T polymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
Hong
H
Weng
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, P. R. China.
Yan
Y
Yan
Evidence-Based Nursing Center, School of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P. R. China.
Ying-Hui
YH
Jin
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
Xiang-Yu
XY
Meng
Department of Stomatology, Daping Hospital &Research Institute of Surgery, Third Military Medical University, Chongqing 400042, P. R. China.
Yuan-Yuan
YY
Mo
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.|Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, P. R. China.
Xian-Tao
XT
Zeng
D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics*; D016017:Odds Ratio; D010518:Periodontitis / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
D020782:Matrix Metalloproteinases