Advances in Bioprinting Technologies for Craniofacial Reconstruction.
Recent developments in craniofacial reconstruction have shown important advances in both the materials and methods used. While autogenous tissue is still considered to be the gold standard for these reconstructions, the harvesting procedure remains tedious and in many cases causes significant donor site morbidity. These limitations have subsequently led to the development of less invasive techniques such as 3D bioprinting that could offer possibilities to manufacture patient-tailored bioactive tissue constructs for craniofacial reconstruction. Here, we discuss the current technological and (pre)clinical advances of 3D bioprinting for use in craniofacial reconstruction and highlight the challenges that need to be addressed in the coming years.
Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Center, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands. Electronic address: dafyddvisscher@me.com.
Dafydd O
DO
Visscher
Department of Oral and Maxillofacial Surgery/Oral Pathology and 3D InnovationLab, VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; Department of Oral Cell Biology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
Elisabet
E
Farré-Guasch
Department of Oral and Maxillofacial Surgery/Oral Pathology and 3D InnovationLab, VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; Department of Orthopaedic Surgery, VU University Medical Center, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
Marco N
MN
Helder
Department of Oral Cell Biology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands.
Susan
S
Gibbs
Department of Oral and Maxillofacial Surgery/Oral Pathology and 3D InnovationLab, VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
Tymour
T
Forouzanfar
Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Center, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; Burn Center, Red Cross Hospital, Beverwijk, The Netherlands.
Paul P
PP
van Zuijlen
Department of Oral and Maxillofacial Surgery/Oral Pathology and 3D InnovationLab, VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
Jan
J
Wolff
D062028:Bioprinting; D019465:Craniofacial Abnormalities / Q000601:surgery; D005145:Face / Q000601:surgery*; D005151:Facial Injuries / Q000601:surgery; D006801:Humans; D019651:Plastic Surgery Procedures; D012886:Skull / Q000601:surgery*; D012887:Skull Fractures / Q000601:surgery; D012888:Skull Neoplasms / Q000601:surgery; D023822:Tissue Engineering
bioactive scaffolds; bioprinting; clinical application; craniofacial reconstruction