[Role of lipin-1 in the pathogenesis of alcoholic fatty liver disease].
Lipin-1 can promote the synthesis of triglyceride and fatty acid oxidation during lipid metabolism. Ethanol can up-regulate the expression of lipin-1 via the AMPK-SREBP-1-lipin-1 signaling pathway and increase lipin1β/αratio via the SITR1-SFRS10-LPIN1 signaling pathway. In the cytoplasm, lipin-1βfunctions as a Mg2+-dependent phosphatidic acid phosphohydrolase to accelerate the synthesis of triglyceride. In the nucleus, lipin-1αacts as a transcriptional coactivator and reduces mitochondrial fatty acid oxidation by inhibiting the activities of PPARαand PGC-1α, and therefore promotes lipid deposition in hepatocytes and causes hepatic steatosis.
Department of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
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Li
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Zhou
D000431:Ethanol; D005234:Fatty Liver; D005235:Fatty Liver, Alcoholic / Q000473:pathology; D005786:Gene Expression Regulation; D022781:Hepatocytes; D050356:Lipid Metabolism; D009930:Organic Chemicals; D010711:Phosphatidate Phosphatase; D015398:Signal Transduction; D015533:Transcriptional Activation; D014280:Triglycerides; D015854:Up-Regulation
D009930:Organic Chemicals; D014280:Triglycerides; C088310:lipine; D000431:Ethanol; D010711:Phosphatidate Phosphatase