The Relationship between Sleep Quality and Brain Amyloid Burden.
To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.



This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator.



Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden.



Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia.
Belinda M
BM
Brown
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia.
Stephanie R
SR
Rainey-Smith
Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia.
Victor L
VL
Villemagne
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia.|School of Psychology, University of Western Australia, Crawley, Western Australia.
Michael
M
Weinborn
School of Psychology, University of Western Australia, Crawley, Western Australia.
Romola S
RS
Bucks
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia.
Hamid R
HR
Sohrabi
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia.
Simon M
SM
Laws
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia.
Kevin
K
Taddei
CSIRO Food and Nutrition, Parkville, Victoria, Australia.
S Lance
SL
Macaulay
Department of Psychiatry, University of Melbourne, Victoria, Australia.|National Ageing Research Institute, Parkville, Victoria, Australia.
David
D
Ames
Florey Institute for Neurosciences and Mental Health, University of Melbourne, Victoria, Australia.
Christopher
C
Fowler
Florey Institute for Neurosciences and Mental Health, University of Melbourne, Victoria, Australia.|Cogstate Ltd., Melbourne, Victoria, Australia.
Paul
P
Maruff
Florey Institute for Neurosciences and Mental Health, University of Melbourne, Victoria, Australia.
Colin L
CL
Masters
Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia.
Christopher C
CC
Rowe
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia.|School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Western Australia.
Ralph N
RN
Martins
D000368:Aged; D000483:Alleles; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000378:metabolism*; D053327:Apolipoprotein E4 / Q000235:genetics; D001921:Brain / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D016014:Linear Models; D008297:Male; D049268:Positron-Emission Tomography; D057566:Self Report; D012890:Sleep / Q000235:genetics / Q000502:physiology*
D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4
Alzheimer disease; apolipoprotein ε4 allele; beta-amyloid; sleep; sleep latency