A direct access to isoxazoles from ynones using trimethylsilyl azide as amino surrogate under metal/catalyst free conditions.
A general method for isoxazoles from readily available ynones using trimethylsilyl azide as an amino surrogate, likely via an unprecedented hydroazidation of the alkyne and denitrogenative cyclization, is demonstrated. The method neither required any catalyst nor demanded unusual conditions to afford the products with outstanding functional group compatibility.
Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India. msreddy@cdri.res.in and Academy of Scientific and Innovative Research, New Delhi 110001, India.
Gadi Ranjith
GR
Kumar
Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India. msreddy@cdri.res.in.
Yalla Kiran
YK
Kumar
Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India. msreddy@cdri.res.in and Academy of Scientific and Innovative Research, New Delhi 110001, India.
Maddi Sridhar
MS
Reddy