Regulation of Memory T Cells by Interleukin-23.
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors. Memory T cells are a subset of T cells that secrete numerous important cell factors, and they function in the immune response to infection and diseases like cancer, autoimmune disease and bronchial asthma. IL-23R is expressed on the surface of memory T cells, which suggests that it can specifically regulate memory T cell function. IL-23 has been widely used as a clinical indicator in immune-related diseases and shows potential for use in disease treatment. Here we review the current progress in the study of the role of IL-23 in the regulation of memory T cells.
Division 1, Pediatric Respiratory Department, The First Hospital of Jilin University, Changchun, China.
Yanchun
Y
Li
Hongbo
H
Wang
Honghua
H
Lu
Shucheng
S
Hua
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory; D056747:Immunomodulation; D053759:Interleukin-23 / Q000235:genetics / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000276:immunology; D011110:Polymorphism, Genetic; D018123:Receptors, Interleukin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*
D016207:Cytokines; C515500:IL23R protein, human; D053759:Interleukin-23; D018123:Receptors, Interleukin