Platelet Transfusions in Patients with Hypoproliferative Thrombocytopenia: Conclusions from Clinical Trials and Current Controversies.
Patients with hematologic malignancies frequently become thrombocytopenic as a result of their underlying malignancy or treatments, including cytotoxic chemotherapy and hematopoietic stem cell transplantation and are at increased risk of hemorrhage. Prophylactic platelet transfusions are aimed at preventing severe or life-threatening hemorrhage. This review summarizes recent evidence, including the need for prophylactic platelet transfusions, the optimal dose, platelet transfusion triggers, and risk factors for bleeding. It also discusses controversies surrounding platelet transfusions in this population.
Department of Epidemiology and Preventive Medicine, The Alfred Centre, Monash University, Level 6, 99 Commercial Road, Melbourne, Victoria, 3181, Australia; Australian Red Cross Blood Service, 100-154 Batman Street, West Melbourne, Victoria, 3003, Australia; Royal Children's Hospital, Department of Haematology, 50 Flemington Road, Parkville, Victoria, 3052, Australia.
Gemma L
GL
Crighton
Radcliffe Department of Medicine, National Health Service Blood and Transplant, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, University of Oxford, Oxford OX3 9BQ, UK.
Lise J
LJ
Estcourt
Department of Epidemiology and Preventive Medicine, The Alfred Centre, Monash University, Level 6, 99 Commercial Road, Melbourne, Victoria, 3181, Australia; Monash Health, Department of Haematology, 246 Clayton Road, Clayton, Victoria, 3168, Australia.
Erica M
EM
Wood
Radcliffe Department of Medicine, National Health Service Blood and Transplant, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, University of Oxford, Oxford OX3 9BQ, UK. Electronic address: simon.stanworth@nhsbt.nhs.uk.
Simon J
SJ
Stanworth
D064591:Allografts; D002986:Clinical Trials as Topic; D018380:Hematopoietic Stem Cell Transplantation; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D017713:Platelet Transfusion; D012307:Risk Factors; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy*
Acute leukemia; Bleeding; Chemotherapy; Hematopoietic stem cell transplantation; Platelet transfusion; Thrombocytopenia