Risk of Stroke in Patients With Spontaneous Pneumothorax: A Nationwide, Population-Based Study.
The association between spontaneous pneumothorax (SP) and stroke has not been reported, and this study aimed to explore this association. We used the National Health Insurance Research Database for conducting a nationwide, population-based, retrospective cohort study of patients newly hospitalized for SP from 2000 to 2010. A total of 2541 patients with newly diagnosed SP were included and compared with patients without SP. We observed that patients with SP were at higher risk for developing stroke, with an adjusted hazard ratio (HR) of 1.56. In addition, these patients had a significantly higher risk of hemorrhagic stroke (adjusted HR = 2.22) than of ischemic stroke (adjusted HR = 1.48). The risk of stroke was the highest in the initial 4 months after hospitalization for SP (adjusted HR = 3.41, 95% confidence interval = 1.98-5.87). In conclusion, our study revealed a correlation between stroke and a history of SP, and the risk of stroke after SP was time sensitive.
From the Division of Chest Medicine, Department of Internal Medicine, Shin Kong Wu-Ho-Su Memorial Hospital, Taipei (C-YC, DY-WY); Department of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City (DY-WY); College of Medicine (C-LL) and Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine (C-HK), China Medical University; and Management Office for Health Data (C-LL) and Department of Nuclear Medicine and PET Center (C-HK), China Medical University Hospital, Taichung, Taiwan.
Ching-Yuan
CY
Cheng
Diana Yu-Wung
DY
Yeh
Cheng-Li
CL
Lin
Chia-Hung
CH
Kao
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult