Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units.
BACKGROUND
Hematocrit (Hct) is an important parameter for optimal oxygenation during discontinuation from ventilator, but there is no consensus about its concentration and effectiveness on successful extubation.


OBJECTIVE
The current study aimed to determine the role of Hct concentration on extubation failure in critically ill patients.


METHODS
The current prospective cohort study investigated the effect of age, gender and Hct level on successful extubation of 163 mechanically ventilated patients in Imam Khomeini hospital intensive care units (ICUs), Tehran, Iran. Following successful weaning process, the patients were classified into two groups on the basis of Hct level; 62 with an Hct level of 21% - 27% and the other 101 patients with Hct levels above 27%. The data were analyzed by chi-square test and multiple logistic regressions. A probability value of less than 0.05 was considered significant.


RESULTS
There was no significant association between the level of Hct concentration and extubation failure (8.9% vs. 9.2%, P = 0.507). Gender and age were significantly associated with extubation failure (OR = 9.1, P = 0.034, OR = 12.5, P = 0.014, respectively). Although the differences between, before and after extubation of PaO2 and P/F ratio, were of significant values between the two different groups of Hct (P = 0.001, P = 0.004 respectively), they had no effect on the failure of extubation (P= 0.259, P = 0.403, respectively).


CONCLUSIONS
Although some studies showed association between anemia and extubation failure, the current study could not confirm it. The study showed that males, regardless of the Hct level, had a better extubation success rate than those of females.
Department of Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Taghi
MT
Beigmohammadi
Department of Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zahid
Z
Hussain Khan
Department of Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Shahram
S
Samadi
Cardiovascular Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Ata
A
Mahmoodpoor
Department of Epidemiology and Statistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Akbar
A
Fotouhi
Department of Epidemiology and Statistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abbas
A
Rahimiforoushani
Division of Respiratory Disease, Department of Internal Medicine, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehrnaz
M
Asadi Gharabaghi
Airway Extubation; Anemia; Critical Illness; Hematocrit