Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression.
BACKGROUND
Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD).


METHODS
People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms.


RESULTS
Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval = 1.18-28.50; P = 0.03).


CONCLUSIONS
People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.
Department of Psychiatry, Taipei City Hospital, Zen-A Branch, Taipei, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Ya-Hsu
YH
Yang
Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.|Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
Chih-Chiang
CC
Chiu
School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hao-Wei
HW
Teng
Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
Chih-Pang
CP
Chu
Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan.
Ching-Jui
CJ
Chang
Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan.
Wei-Che
WC
Chiu
Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Department of Psychiatry, Taipei Medical University - Wan Fang Hospital, Taipei, Taiwan.
Chin-Hsin
CH
Chen
Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Department of Psychiatry, Taipei Medical University - Wan Fang Hospital, Taipei, Taiwan.
Mong-Liang
ML
Lu
Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.
Shen-Ing
SI
Liu
Department of Nutrition, School of Nutrition and Health Science, Taipei Medical University, Taipei, Taiwan.
Shih-Yi
SY
Huang
Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.|Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
Hsing-Cheng
HC
Liu
Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.
I-Wen
IW
Sun
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics; D060825:Cognitive Dysfunction / Q000150:complications / Q000235:genetics*; D003866:Depressive Disorder / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D001057:Apolipoproteins E; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase