Asymmetric Intramolecular Desymmetrization of meso-α,α'-Diazido Alcohols with Aryldiazoacetates: Assembly of Chiral C3 Fragments with Three Continuous Stereocenters.
The chiral Cu-complex-catalyzed intramolecular interception of meso-α,α'-diazido alcohols with aryldiazoacetates is explored. Most of the enantioenriched α-imino esters with three continuous stereocenters are produced with good to excellent yield and enantioselectivity, and a chiral pocket model is proposed for rationalization of the asymmetric desymmetrization.
Key Laboratory of Energy Sources & Engineering, State Key Laboratory Cultivation Base of Natural Gas Conversion and Department of Chemistry, Ningxia University , Yinchuan 750021, China.
Jin-Bao
JB
Qiao
School of Chemistry & Chemical Engineering, Shaanxi Normal University , Xi'an 710119, China.
Yu-Ming
YM
Zhao
Key Laboratory of Energy Sources & Engineering, State Key Laboratory Cultivation Base of Natural Gas Conversion and Department of Chemistry, Ningxia University , Yinchuan 750021, China.
Peiming
P
Gu