Self-assembly and β-carotene loading capacity of hydroxyethyl cellulose-graft-linoleic acid nanomicelles.
A series of linoleic acid conjugated hydroxyethyl cellulose polymers (HEC-g-LA) were synthesized and characterized. And their solubilities in a variety of solvents were compared. The prepared HEC-g-LA polymers showed typical properties of amphiphilic polymers and were able to self-assemble into spherical nanomicelles in aqueous solution. The micelle sizes and critical micelle concentrations (CMC) were found correlated with the molecular structure of polymers, and were varied in the range of 20-50nm and 1.92-21.76μg/ml, respectively. Furthermore, the hydrophobic active component β-carotene (β-C) was successfully encapsulated into the HEC-g-LA micelles by sonication-dialysis method. The β-C encapsulation efficiency and loading content were found to be as high as 84.67% (w/w) and 4.23%. The results of in vitro release showed that the encapsulated β-C was continuously released from the micelles in phosphate buffered saline (PBS) medium for about 7days. The self-assembled HEC-g-LA nanomicelles are potential nanocarriers of hydrophobic active compounds for functional food applications.
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, PR China.
Yang
Y
Yang
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, PR China; Liaoning Key Laboratory of Pulp and Paper Engineering, Dalian Polytechnic University, Dalian 116034, PR China.
Yanzhu
Y
Guo
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, PR China; Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, PR China.
Runcang
R
Sun
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, PR China. Electronic address: fewangxh@scut.edu.cn.
Xiaohui
X
Wang
D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D019787:Linoleic Acid / Q000737:chemistry*; D008823:Micelles; D010316:Particle Size; D019207:beta Carotene / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; D019207:beta Carotene; D002482:Cellulose; C002283:hydroxyethylcellulose; D019787:Linoleic Acid
Drug delivery; Hydroxyethyl cellulose (HEC); Linoleic acid (LA); Nanomicelles