Chemical Composition and Antinociceptive Potential of Campomanesia reitziana Fruits.
The methanolic extract from Campomanesia reitziana fruits and the main active principle, identified as 4',6'-dihydroxy-3',5'-dimethyl-2'-methoxy chalcone or dimethyl cardamonin (1), exhibited pronounced antinociceptive effects against two models of pain in mice. Compound 1 caused dose-dependent inhibition of abdominal constrictions, with a calculated ID50 value of 8.1 (6.5-10.1) μmol/kg (i.p.), being about 16-fold more potent than two reference analgesic drugs. Methanolic extract and 1 were also effective against the formalin model, inhibiting both phases of pain, causing reductions of 39.9% and 26.8% (extract, 10 mg/kg) and 52.9% and 57.6% (compound 1, 5 mg/kg) for the first and second phases, respectively.
1 Post Graduate Program in Pharmaceutical Sciences, Pharmaceutical Chemical-Investigations Center (NIQFAR), University of Vale do Itajaí-UNIVALI , Itajaí, Santa Catarina, Brazil .
Luciane Angela Nottar
LA
Nesello
1 Post Graduate Program in Pharmaceutical Sciences, Pharmaceutical Chemical-Investigations Center (NIQFAR), University of Vale do Itajaí-UNIVALI , Itajaí, Santa Catarina, Brazil .
Adriana
A
Campos
1 Post Graduate Program in Pharmaceutical Sciences, Pharmaceutical Chemical-Investigations Center (NIQFAR), University of Vale do Itajaí-UNIVALI , Itajaí, Santa Catarina, Brazil .
Theodoro
T
Wagner
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS-IBSAL, University of Salamanca , Salamanca, Spain .
Arturo San
AS
Feliciano
1 Post Graduate Program in Pharmaceutical Sciences, Pharmaceutical Chemical-Investigations Center (NIQFAR), University of Vale do Itajaí-UNIVALI , Itajaí, Santa Catarina, Brazil .
Fátima
F
de Campos Buzzi
1 Post Graduate Program in Pharmaceutical Sciences, Pharmaceutical Chemical-Investigations Center (NIQFAR), University of Vale do Itajaí-UNIVALI , Itajaí, Santa Catarina, Brazil .
Valdir Cechinel
VC
Filho
D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry*; D000818:Animals; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008297:Male; D051379:Mice; D027822:Myrtaceae / Q000737:chemistry*; D010146:Pain / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry*
D000700:Analgesics; D010936:Plant Extracts
Campomanesia reitziana fruits; antinociception; chalcone; formalin model; writhing test