Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients.
Psoriasis is a common, enigmatic, and recurrent disease. The precise etiology and pathogenesis of psoriasis are still unclear. Psoriasis has been treated as an inflammatory disorder related to an underlying Th1/Th17-dominated immune response. Interleukins are involved in the development of psoriasis lesions through Th-17-associated inflammation. Th1 and Th17 cytokines are found in skin lesions and in the peripheral blood of psoriasis patients. We sought to analyze serum levels of IL-1-β, IL-8, IL-9, IL-27, IL-29, IL-35, IFN-γ, TNF and TGF-β in patients with psoriasis and healthy control volunteers. Blood samples were collected from fifty-three patients with psoriasis and thirty-five healthy controls. Serum cytokines concentrations were determined using an enzyme-linked immunosorbent assay. Serum IL-8, IL-9, IL-27, IL-29 and TNF levels were statistically significant in psoriasis patients. Detectable serum IL-9 levels were found in 47 patients of the 53 in the psoriasis group. Interleukins-8, 27, 29 and TNF levels measured in the serum of psoriasis patients were slightly elevated as compared to healthy controls in a weakly significant way. On the other hand, there were highly significant differences in IL-9 levels between the two groups.
Laboratory of Immunomodulation and Novel Therapeutic Approaches (LINAT), Research Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), UFPE, Recife, Brazil.
Pablo Ramon Gualberto
PR
Cardoso
Laboratory of Immunomodulation and Novel Therapeutic Approaches (LINAT), Research Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), UFPE, Recife, Brazil, Clinics Hospital, Federal University of Pernambuco (UFPE), Recife, Brazil.
Emerson Vasconcelos de Andrade
EV
Lima
Laboratory of Immunomodulation and Novel Therapeutic Approaches (LINAT), Research Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), UFPE, Recife, Brazil.
Mariana Modesto de Andrade
MM
Lima
Clinics Hospital, Federal University of Pernambuco (UFPE), Recife, Brazil.
Moacyr Jesus Barreto de Melo
MJ
Rêgo
Clinics Hospital, Federal University of Pernambuco (UFPE), Recife, Brazil.
Claudia Diniz Lopes
CD
Marques
Laboratory of Immunomodulation and Novel Therapeutic Approaches (LINAT), Research Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), UFPE, Recife, Brazil.
Ivan da Rocha
Ida R
Pitta
Laboratory of Immunomodulation and Novel Therapeutic Approaches (LINAT), Research Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), UFPE, Recife, Brazil.
Angela Luzia Branco Pinto
AL
Duarte
Laboratory of Immunomodulation and Novel Therapeutic Approaches (LINAT), Research Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), UFPE, Recife, Brazil.
Maira Galdino da Rocha
MG
Pitta
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001799:Blood Sedimentation; D001938:Brazil; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D012680:Sensitivity and Specificity; D055815:Young Adult
D015415:Biomarkers; D016207:Cytokines; D007166:Immunosuppressive Agents
Brazilian Patients; IL-27; IL-29; IL-8; IL-9; psoriasis