Transcription factor SGF1 is critical for the neurodevelopment in the silkworm, Bombyx mori.
FoxA transcription factors play vital roles in regulating the expression of organ-specific genes. BmSGF1, the sole FoxA family member in Bombyx mori, is required for development of the silk gland. However, the function of BmSGF1 in development of the nervous system in the silkworm remains unknown. Here, we show that the amino acids sequence of BmSGF1 is evolutionarily conserved in its middle region from Trichoplax adhaerens to human and diverged from the homologues in most other species in its N-terminal region. BmSGF1 expresses in the nervous system at the embryonic stage. Knockdown of Bmsgf1 by RNA interference (RNAi) results in abnormal development of axons. Therefore, our results demonstrate that BmSGF1 is an indispensable regulator for neurodevelopment.
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Zhao-Yang
ZY
Liu
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Qi
Q
Yu
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Chun-Hong
CH
Yang
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Miao
M
Meng
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Chun-Jiu
CJ
Ren
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Zhi-Mei
ZM
Mu
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Wei-Zheng
WZ
Cui
Laboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong 271018, China. Electronic address: liuqingxin@sdau.edu.cn.
Qing-Xin
QX
Liu
D000818:Animals; D012831:Bombyx / Q000254:growth & development* / Q000378:metabolism*; D019476:Insect Proteins / Q000737:chemistry / Q000378:metabolism*; D009420:Nervous System; D010802:Phylogeny; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*
D019476:Insect Proteins; D014157:Transcription Factors
BmSGF1; Bombyx mori; Neurodevelopment; RNA interference