2'-Modified Guanosine Analogs for the Treatment of HCV.
Novel 2'-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7-10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2'-olefin. The antiviral effectiveness of the guanosine nucleosides was evaluated by converting them to the corresponding 5'-O-triphosphates (compounds 38-44) and testing their biochemical inhibitory activity against the wild-type NS5B polymerase.
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Vinay
V
Girijavallabhan
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Ashok
A
Arasappan
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Frank
F
Bennett
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Kevin
K
Chen
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Qun
Q
Dang
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Ying
Y
Huang
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Angela
A
Kerekes
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Latha
L
Nair
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Dmitri
D
Pissarnitski
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Vishal
V
Verma
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Carmen
C
Alvarez
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Ping
P
Chen
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
David
D
Cole
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Sara
S
Esposite
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Yuhua
Y
Huang
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Qingmei
Q
Hong
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Zhidan
Z
Liu
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Weidong
W
Pan
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Haiyan
H
Pu
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Randall
R
Rossman
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Quang
Q
Truong
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Bancha
B
Vibulbhan
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Jun
J
Wang
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Zhiqiang
Z
Zhao
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
David
D
Olsen
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Andrew
A
Stamford
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
Stephane
S
Bogen
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.
F George
FG
Njoroge
D000475:Alkenes / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001386:Azides / Q000138:chemical synthesis; D006150:Guanine Nucleotides / Q000138:chemical synthesis*; D016174:Hepacivirus / Q000201:enzymology; D019384:Nucleic Acid Synthesis Inhibitors / Q000138:chemical synthesis*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase
D000475:Alkenes; D000998:Antiviral Agents; D001386:Azides; D006150:Guanine Nucleotides; D019384:Nucleic Acid Synthesis Inhibitors; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase