Risk of lymph node metastasis in mixed-type early gastric cancer determined by the extent of the poorly differentiated component.
To predict the rate of lymph node (LN) metastasis in diffuse- and mixed-type early gastric cancers (EGC) for guidelines of the treatment.



We reviewed 550 cases of EGC with diffuse- and mixed-type histology. We investigated the clinicopathological factors and histopathological components that influence the probability of LN metastasis, including sex, age, site, gross type, presence of ulceration, tumour size, depth of invasion, perineural invasion, lymphovascular invasion, and LN metastasis status. We reviewed all slides and estimated the proportions of each tumour component; pure diffuse type, mixed-predominantly diffuse type (diffuse > intestinal type), mixed-predominantly intestinal type (intestinal > diffuse type), and mixed diffuse = intestinal type. We calculated the extents of the respective components.



LN metastasis was observed in 12.9% (71/550) of early gastric cancers cases [15/288 mucosal EGCs (5.2%) and 56/262 submucosal EGCs (21.4%)]. Of 550 cases, 302 were diffuse-type and 248 were mixed-type EGCs. Of 248 mixed-type EGCs, 163 were mixed-predominantly diffuse type, 82 were mixed-predominantly intestinal type, and 3 were mixed diffuse = intestinal type. Mixed-type cases with predominantly diffuse type histology showed a higher frequency of LN metastasis (20.2%) than cases of pure diffuse type (9.3%) and predominantly intestinal type (12.2%) histology. We measured the dimensions of each component (intestinal and diffuse type) to determine the association of the extent of each component with LN metastasis in mixed-type gastric carcinoma. The total tumour size and the extent of poorly differentiated components was associated with LN metastasis, while that of signet ring cell components was not.



We recommend careful identification and quantitative evaluation of mixed-type early gastric cancer components after endoscopic resection to determine the intensity of the treatment.
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Chung-Su
CS
Hwang
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Sangjeong
S
Ahn
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Bong-Eun
BE
Lee
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
So-Jeong
SJ
Lee
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Ahrong
A
Kim
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Chang In
CI
Choi
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Dae Hwan
DH
Kim
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Tae-Yong
TY
Jeon
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Gwang Ha
GH
Kim
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Geum Am
GA
Song
Chung-Su Hwang, Sangjeong Ahn, So-Jeong Lee, Ahrong Kim, Do Youn Park, Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan 602-739, South Korea.
Do Youn
DY
Park
D001706:Biopsy; D018279:Carcinoma, Signet Ring Cell / Q000556:secondary* / Q000601:surgery; D002454:Cell Differentiation; D005260:Female; D005743:Gastrectomy / Q000379:methods; D005773:Gastroscopy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018193:Neoplasms, Complex and Mixed / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D047368:Tumor Burden
Endoscopic gastrointestinal surgery; Gastric cancer; Histology; Lymph nodes; Metastasis