Singlet molecular oxygen: Düsseldorf - São Paulo, the Brazilian connection.
Inspired by Helmut Sies we continue the development of suitable chemical generators of (1)O2 based on the thermodissociation of naphthalene endoperoxide derivatives. The present manuscript focuses on how the use of [(18)O]-labeled endoperoxides and hydroperoxides can be applied to study mechanistic aspects related to the generation of singlet molecular oxygen and its reactions in biological systems. The peroxidation reactions of the main cellular targets including unsaturated lipids, proteins and nucleic acids have received major attention during the last three decades. Emphasis is placed in this manuscript on the description of the synthesis and the main use of [(18)O]-labeled compounds, and especially of peroxides and (1)O2, for tracer elucidation of reaction mechanisms.
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05508-000, São Paulo, SP, Brazil. Electronic address: pdmascio@iq.usp.br.
Paolo
P
Di Mascio
Departamento de Bioquímica e Biologia Molecular, Setor de Ciências Biológicas, Universidade Federal do Paraná, 81531990, Curitiba, PR, Brazil.
Glaucia R
GR
Martinez
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05508-000, São Paulo, SP, Brazil.
Sayuri
S
Miyamoto
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05508-000, São Paulo, SP, Brazil.
Graziella E
GE
Ronsein
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05508-000, São Paulo, SP, Brazil.
Marisa H G
MH
Medeiros
Université de Sherbrooke, Sherbrooke, Québec JIH 5N4, Canada; CEA, INAC, F-38000, Grenoble, France.
Jean
J
Cadet
D001938:Brazil; D010545:Peroxides / Q000737:chemistry*; D026082:Singlet Oxygen
D010545:Peroxides; D026082:Singlet Oxygen
Lipids; Naphthalene endoperoxide; Nucleic acids; Proteins; Singlet oxygen; [(18)O]-Labeled compounds