Prolonged effects of miconazole oral gel on warfarin anticoagulation even after treatment withdrawal.
OBJECTIVE
We investigated the effect of terminating miconazole oral gel (MOG) treatment on the anticoagulant activity of warfarin by evaluating changes in international normalized ratio levels (INR).


METHODS
Data were collected from the medical records of 6 patients treated with warfarin and MOG.


RESULTS
Following cessation of MOG treatment, increased INR and INR/dose levels were observed for an average of 15 days, showing that the anticoagulant activity of warfarin was increased for ~ 2 weeks.


CONCLUSIONS
Closer monitoring of INR levels for at least 2 weeks may be required upon withdrawal of MOG treatment in patients treated with warfarin.
Satoshi
S
Murakami
Akihiro
A
Tanaka
Keiko
K
Ido
Mamoru
M
Tanaka
Hiroaki
H
Araki
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000494:pharmacology*; D005260:Female; D005782:Gels; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008825:Miconazole / Q000494:pharmacology*; D008875:Middle Aged; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D005782:Gels; D014859:Warfarin; D008825:Miconazole