Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications.
Nanobiomaterials such as virus particles and artificial virus particles offer tremendous opportunities to develop new biomedical applications such as drug- or gene-delivery, imaging and sensing but also improve understanding of biological mechanisms. Recent advances within the field of virus-based systems give insights in how to mimic viral structures and virus assembly processes as well as understanding biodistribution, cell/tissue targeting, controlled and triggered disassembly or release and circulation times. All these factors are of high importance for virus-based functional systems. This review illustrates advances in mimicking and enhancing or controlling these aspects to a high degree toward delivery and imaging applications.
University of Groningen, University Medical Center Groningen, Biomedical Engineering-FB40, W.J. Kolff Institute for Biomedical Engineering and Materials Science-FB41, Antonius Deusinglaan 1, 9713, AW, Groningen, Netherlands.|Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747, AG, Groningen, Netherlands.
Patrick
P
van Rijn
University of Groningen, University Medical Center Groningen, Biomedical Engineering-FB40, W.J. Kolff Institute for Biomedical Engineering and Materials Science-FB41, Antonius Deusinglaan 1, 9713, AW, Groningen, Netherlands.
Romana
R
Schirhagl
D000818:Animals; D035843:Biomedical Research; D040761:Biomimetic Materials; D003952:Diagnostic Imaging / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D018014:Gene Transfer Techniques; D006801:Humans; D014780:Viruses
biomedical applications; delivery; imaging; nanobiomaterials; virus particles