Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery.
A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) with functional peptide-coated gold nanoparticles (GNPs). MSNs are first functionalized with acid-labile α-amide-β-carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo-lysine-containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to αvβ3 integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides.
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057, P. R. China.
Ganchao
G
Chen
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057, P. R. China.
Yusheng
Y
Xie
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057, P. R. China.
Raoul
R
Peltier
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057, P. R. China.
Haipeng
H
Lei
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057, P. R. China.
Ping
P
Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS) , Beijing 100049, P. R. China.
Jun
J
Chen
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS) , Beijing 100049, P. R. China.
Yi
Y
Hu
Feng
F
Wang
Xi
X
Yao
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057, P. R. China.
Hongyan
H
Sun
D016503:Drug Delivery Systems; D006046:Gold; D006801:Humans; D053768:Metal Nanoparticles; D010455:Peptides; D016062:Porosity; D012822:Silicon Dioxide
D010455:Peptides; D006046:Gold; D012822:Silicon Dioxide
charge reversal; controlled release; gold nanoparticles; peptides; targeted delivery