RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications.
During transcription elongation, RNA polymerase II (pol II) travels along the DNA template across thousands to millions of nucleotides and accurately synthesizes the complementary RNA transcripts. Apart from its canonical function as a key enzyme for DNA-dependent RNA synthesis, pol II also functions as a selective sensor to recognize DNA lesions or epigenetic modifications.
a Department of Cellular and Molecular Medicine , School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California , San Diego, La Jolla , CA , USA.
Ji Hyun
JH
Shin
a Department of Cellular and Molecular Medicine , School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California , San Diego, La Jolla , CA , USA.
Liang
L
Xu
a Department of Cellular and Molecular Medicine , School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California , San Diego, La Jolla , CA , USA.
Dong
D
Wang
D004247:DNA / Q000737:chemistry / Q000235:genetics*; D004249:DNA Damage; D044127:Epigenesis, Genetic; D006801:Humans; D008958:Models, Molecular; D012319:RNA Polymerase II / Q000737:chemistry* / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
D012333:RNA, Messenger; D004247:DNA; D012319:RNA Polymerase II
DNA lesions; DNA modifications; RNA polymerase II; epi-DNA recognition loop; sensor