Self-generated chemotactic gradients-cells steering themselves.
Chemotaxis is a fundamentally important part of biology, but we know very little about how gradients of chemoattractant are formed. One answer is self-generated gradients, in which the moving cells break down the attractant to provide their own gradient as they migrate. Here we discuss where self-generated gradients are known, how they can be recognized, and where they are likely to be found in the future.
Cancer Research UK Beatson Institute, Switchback Road, Bearsden G61 1BD, UK.
Luke
L
Tweedy
Cancer Research UK Beatson Institute, Switchback Road, Bearsden G61 1BD, UK.
Olivia
O
Susanto
Cancer Research UK Beatson Institute, Switchback Road, Bearsden G61 1BD, UK. Electronic address: R.Insall@beatson.gla.ac.uk.
Robert H
RH
Insall
D000818:Animals; D002630:Chemotactic Factors / Q000378:metabolism*; D002633:Chemotaxis; D025461:Feedback, Physiological; D006801:Humans; D059748:Proteolysis
D002630:Chemotactic Factors