Assessment of Fat distribution and Bone quality with Trabecular Bone Score (TBS) in Healthy Chinese Men.
Whether fat is beneficial or detrimental to bones is still controversial, which may be due to inequivalence of the fat mass. Our objective is to define the effect of body fat and its distribution on bone quality in healthy Chinese men. A total of 228 men, aged from 38 to 89 years, were recruited. BMD, trabecular bone score (TBS), and body fat distribution were measured by dual-energy X-ray absorptiometry. Subcutaneous and visceral fat were assessed by MRI. In the Pearson correlation analysis, lumbar spine BMD exhibited positive associations with total and all regional fat depots, regardless of the fat distribution. However, the correlation disappeared with adjusted covariables of age, BMI, HDL-C, and HbA1c%. TBS was negatively correlated with fat mass. In multiple linear regression models, android fat (and not gynoid, trunk, or limbs fat) showed significant inverse association with TBS (β = -0.611, P < 0.001). Furthermore, visceral fat was described as a pathogenic fat harmful to TBS, even after adjusting for age and BMI (β = -0.280, P = 0.017). Our findings suggested that body fat mass, especially android fat and visceral fat, may have negative effects on bone microstructure; whereas body fat mass contributes to BMD through mechanical loading.
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Shan
S
Lv
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Aisen
A
Zhang
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Wenjuan
W
Di
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Yunlu
Y
Sheng
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Peng
P
Cheng
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Hanmei
H
Qi
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Juan
J
Liu
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Jing
J
Yu
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Guoxian
G
Ding
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Jinmei
J
Cai
Department of Gerontology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 Jiangsu, P.R. China.
Bin
B
Lai
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050218:Body Fat Distribution; D015519:Bone Density; D000071556:Cancellous Bone; D002681:China; D006801:Humans; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D050151:Subcutaneous Fat / Q000033:anatomy & histology