Microtubules: 50 years on from the discovery of tubulin.
Next year will be the 50th anniversary of the discovery of tubulin. To celebrate this discovery, six leaders in the field of microtubule research reflect on key findings and technological breakthroughs over the past five decades, discuss implications for therapeutic applications and provide their thoughts on what questions need to be addressed in the near future.
Forsyth Institute, 245 First Street, Cambridge, Massachusetts 02142, USA.
Gary
G
Borisy
Division of Cell and Developmental Biology and Molecular and Cell Biology Department, University of California, Berkeley, California 94720, USA.
Rebecca
R
Heald
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.
Jonathon
J
Howard
Institut Curie, PSL Research University, CNRS UMR3348, Centre Universitaire, Bâtiment 110, F-91405 Orsay, France.
Carsten
C
Janke
Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany; and the Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitätsstrasse, 45141 Essen, Germany.
Andrea
A
Musacchio
Biochemistry, Biophysics and Structural Biology Division, Molecular and Cell Biology Department, University of California, Berkeley, California 94720-3220, USA; the Howard Hughes Medical Institute, Maryland, USA; and the Lawrence Berkeley National Laboratory, USA.
Eva
E
Nogales
D000818:Animals; D003585:Cell Biology / Q000266:history; D049673:History, 20th Century; D006801:Humans; D008870:Microtubules / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy; D014404:Tubulin / Q000266:history / Q000502:physiology*; D050257:Tubulin Modulators / Q000494:pharmacology / Q000627:therapeutic use
D014404:Tubulin; D050257:Tubulin Modulators