Serum Paraoxonase Levels are Correlated with Impaired Aortic Functions in Patients with Chronic Kidney Disease.
BACKGROUND
The correlation between aortic functions and paraoxonase levels has been previously demonstrated by several earlier studies. In this study, we aimed to investigate the correlation between serum paraoxonase levels and aortic functions among patients with chronic kidney disease.


METHODS
Our study enrolled 46 chronic kidney disease patients and 45 healthy controls. From these patients, serum cholesterol, creatinine, hemoglobin, and paraoxonase-1 levels were analyzed.


RESULTS
Paraoxonase-1 levels were significantly lower in patients with chronic kidney disease compared to the controls (p < 0.001). Additionally, the extent of aortic stiffness index (%) was significantly higher in chronic kidney disease patients, but aortic strain and aortic distensibility were significantly higher in healthy controls (p < 0.001, p < 0.001, and p < 0.001, respectively). We further found that paraoxonase-1 levels were correlated with aortic stiffness index, aortic strain, and aortic distensibility (p < 0.001, p < 0.001, and p < 0.001, respectively).


CONCLUSIONS
Our study demonstrated that serum paraoxonase-1 levels were significantly correlated with impaired aortic functions. The results of this study highlight the impact of serum paraoxonase-1 activity on atherosclerosis and cardiovascular adverse events.


BACKGROUND
Aortic functions; Atherosclerosis; Chronic kidney disease; Echocardiography; Paraoxonase.
Department of Cardiology, Diskapi Yildirim Beyazit Education and Research Hospital;
Tolga H
TH
Efe
Department of Cardiology, Ankara Penal Institution Campus State Hostital;
Ahmet G
AG
Ertem
Department of Nephrology;
Alpaslan
A
Altunoglu
Department of Cardiology, Ankara Ataturk Training and Research Hospital, Ankara;
Cemal
C
Koseoglu
Department of Cardiology, Pazarcik State Hospital, Kahramanmaras, Turkey.
Ali
A
Erayman
Department of Cardiology, Diskapi Yildirim Beyazit Education and Research Hospital;
Murat
M
Bilgin
Department of Cardiology, Ankara Ataturk Training and Research Hospital, Ankara;
Özge
Ö
Kurmuş
Department of Cardiology, Ankara Ataturk Training and Research Hospital, Ankara;
Turgay
T
Aslan
Department of Cardiology, Ankara Ataturk Training and Research Hospital, Ankara;
Mehmet
M
Bilge