Effects of highly concentrated hyaluronic acid filler on nasolabial fold correction: A 24-month extension study.
BACKGROUND
A previous 6-month study using a more highly concentrated novel hyaluronic acid (HA) filler, PP-501-B, found nasolabial fold (NLF) improvements with increased tolerability.


OBJECTIVE
We investigated the long-term efficacy, durability and safety of PP-501-B in the correction of NLFs.


METHODS
Subjects completing the initial six-month study were enrolled in this 24-month, randomized, multicenter, double-blind, split-face, extension study. The injection areas and treatment procedures were identical to those of the initial study: each subject was injected with PP-501-B in one NLF and with Restylane Perlane (Q-med) in the contralateral NLF. We reassessed wrinkle improvement using the five-point Wrinkle Severity Rating Scale (WSRS) and changes in the Global Aesthetic Improvement Scale at 12, 18 and 24 months after the initial treatment.


RESULTS
Of the 81 patients enrolled, 72 completed the study. The WSRS score significantly decreased from baseline throughout the follow-up period after retreatment with both fillers. There was no significant difference in the WSRS scores between the two fillers at 24 months. Both fillers were well tolerated with no severe complications or adverse reactions.


CONCLUSIONS
The new HA filler PP-501-B is safe and effective in the long term for the correction of moderate-to-severe NLFs, even after a second treatment.
a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Tai Kyung
TK
Noh
a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Hye Rim
HR
Moon
a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Ji Su
JS
Yu
a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Sung Eun
SE
Chang
a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Ik Jun
IJ
Moon
b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.
Sun Young
SY
Choi
b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.
Won Jong
WJ
Oh
a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Chong Hyun
CH
Won
b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.
Beom Joon
BJ
Kim
c Department of Dermatology , KonKuk University College of Medicine , Seoul , Korea.
Yang Won
YW
Lee
D000328:Adult; D003357:Cosmetic Techniques / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D007267:Injections; D008297:Male; D008875:Middle Aged; D060052:Nasolabial Fold; D019233:Retreatment
C560019:Restylane Perlane; D006820:Hyaluronic Acid
Hyaluronic acid; extension study; nasolabial fold