The secondary coordination sphere controlled reactivity of a ferric-superoxo heme: unexpected conversion to a ferric hydroperoxo intermediate by reaction with a high-spin ferrous heme.
A bio-inspired heme complex involving both a proton donor and an axial imidazole ligand reduces the activation energy for the formation of a ferric hydroperoxo intermediate. A high-spin ferrous heme is shown to be capable of reducing its superoxy species to generate a ferric hydroperoxo intermediate for the first time.
Institute of Science and Technology Research, Chubu University, Kasugai, Aichi 487-8501, Japan. naruta@isc.chubu.ac.jp.
Perumandla
P
Nagaraju
Takehiro
T
Ohta
Jin-Gang
JG
Liu
Takashi
T
Ogura
Yoshinori
Y
Naruta