The molecular clutch model for mechanotransduction evolves.
Many biological processes are influenced by the mechanical rigidity of surrounding tissues. Now, a combination of experiments and mathematical modelling has been used to describe the precise molecular and physical mechanism by which cells sense and respond to the mechanical properties of their extracellular environment through integrin-based adhesions.
Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-8019, USA.
Vinay
V
Swaminathan
Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-8019, USA.
Clare M
CM
Waterman
D016023:Integrins; D040542:Mechanotransduction, Cellular
D016023:Integrins