Bugs and Brain: How Infection Makes You Feel Blue.
In this issue of Immunity, Prinz and colleagues (2016) describe an unexpected mechanism underlying the role of type I interferon in the initiation of cognitive impairment and sickness behavior during viral infection through induction of chemokine CXCL10 in central nervous system epithelial and endothelial cells.
Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: jh2vc@virginia.edu.
Jasmin
J
Herz
Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: kipnis@virginia.edu.
Jonathan
J
Kipnis
D001921:Brain / Q000378:metabolism*; D054357:Chemokine CXCL10; D006801:Humans; D014777:Virus Diseases
D054357:Chemokine CXCL10