Very Low Dose Amitriptyline for Clozapine-Associated Sialorrhea.
Clozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87-100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution of sialorrhea after three days without any emergent adverse effect.
Siddhartha
S
Sinha
Jayati
J
Simlai
Associate Professor, Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India - 576104. samirpsyche@yahoo.co.in.
Samir K
SK
Praharaj
D000639:Amitriptyline / Q000008:administration & dosage*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy; D012798:Sialorrhea / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D000639:Amitriptyline; D003024:Clozapine