African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever.
African swine fever (ASF) is an emerging disease threat for the swine industry worldwide. No ASF vaccine is available and progress is hindered by lack of knowledge concerning the extent of ASFV strain diversity and the viral antigens conferring type-specific protective immunity in pigs. Available data from vaccination/challenge experiments in pigs indicate that ASF protective immunity may be haemadsorption inhibition (HAI) serotype-specific. Recently, we have shown that two ASFV proteins, CD2v (EP402R) and C-type lectin (EP153R), are necessary and sufficient for mediating HAI serological specificity (Malogolovkin et al., 2015).. Here, using ASFV inter-serotypic chimeric viruses and vaccination/challenge experiments in pigs, we demonstrate that serotype-specific CD2v and/or C-type lectin proteins are important for protection against homologous ASFV infection. Thus, these viral proteins represent significant protective antigens for ASFV that should be targeted in future vaccine design and development. Additionally, these data support the concept of HAI serotype-specific protective immunity.
National Research Institute for Veterinary Virology and Microbiology, Russian Academy of Agriculture Science, Pokrov, Russian Federation.
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G
Burmakina
National Research Institute for Veterinary Virology and Microbiology, Russian Academy of Agriculture Science, Pokrov, Russian Federation.
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A
Malogolovkin
Department of Pathobiology and Veterinary Science and Center of Excellence for Vaccine Research, University of Connecticut, Storrs, Connecticut, USA.
E R
ER
Tulman
United States Department of Agriculture, Agricultural Research Service, Southeast Poultry Research Laboratory, Athens, GA, USA.
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L
Zsak
School of Veterinary and Biomedical Sciences and Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, USA.
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G
Delhon
Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
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DG
Diel
National Research Institute for Veterinary Virology and Microbiology, Russian Academy of Agriculture Science, Pokrov, Russian Federation.
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Shobogorov
National Research Institute for Veterinary Virology and Microbiology, Russian Academy of Agriculture Science, Pokrov, Russian Federation.
Yu P
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Morgunov
National Research Institute for Veterinary Virology and Microbiology, Russian Academy of Agriculture Science, Pokrov, Russian Federation.
S Yu
SY
Morgunov
Department of Pathobiology and Veterinary Science and Center of Excellence for Vaccine Research, University of Connecticut, Storrs, Connecticut, USA.
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GF
Kutish
National Research Institute for Veterinary Virology and Microbiology, Russian Academy of Agriculture Science, Pokrov, Russian Federation.
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D
Kolbasov
Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
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Rock
D000357:African Swine Fever / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D000358:African Swine Fever Virus / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D037181:Lectins, C-Type / Q000276:immunology; D065288:Serogroup; D013552:Swine / Q000821:virology; D013553:Swine Diseases / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D037181:Lectins, C-Type; D014764:Viral Proteins; D014765:Viral Vaccines