Association between total antioxidant capacity and mortality in ischemic stroke patients.
OBJECTIVE
Data on circulating total antioxidant capacity (TAC) levels in ischemic stroke patients compared with healthy controls are limited and provided conflicting findings. There are not data about the association between circulating TAC levels, peroxidation state and outcome in patients with severe ischemic stroke. The objective of this study was to examine the relationship of TAC with 30-day mortality after severe ischemic stroke.


METHODS
This multicenter study included 58 patients with coma (Glasgow Coma Scale < 9) following severe malignant middle cerebral artery infarction (MMCAI). We measured circulating levels of TAC and malondialdehyde (MDA, a biomarker of lipid peroxidation) on day 1 of severe MMCAI diagnosis. The study endpoint was 30-day mortality.


RESULTS
Non-survivors (n = 29) showed higher serum TAC levels (p < 0.001) and higher serum MDA levels (p = 0.004) than survivors (n = 29). Multiple binomial logistic regression analysis showed that serum TAC levels were associated with 30-day mortality, after controlling for Glasgow Coma Scale and age (odds ratio 1.92; 95 % confidence interval 1.201-3.072; p = 0.006). There was a correlation between serum TAC and MDA levels (rho = 0.35; p = 0.008).


CONCLUSIONS
This single-center study in severe MMCAI patients found an association between higher serum TAC levels and 30-day mortality and further identified a relationship between serum TAC levels, lipid peroxidation state and mortality after severe ischemic stroke.
Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, 38320, La Laguna, Santa Cruz de Tenerife, Spain. lorentemartin@msn.com.
Leonardo
L
Lorente
Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Crta del Rosario s/n, 38010, Santa Cruz de Tenerife, Spain.
María M
MM
Martín
Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n, 38320, La Laguna, Santa Cruz de Tenerife, Spain.
Antonia
A
Pérez-Cejas
Department of Physiology, Faculty of Medicine, University of the La Laguna, Santa Cruz de Tenerife, Spain.
Pedro
P
Abreu-González
Intensive Care Unit, Hospital General La Palma, Buenavista de Arriba s/n, Breña Alta, 38713, La Palma, Spain.
Luis
L
Ramos
Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez nº17-19, 46004, Valencia, Spain.
Mónica
M
Argueso
Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain.
Juan J
JJ
Cáceres
Intensive Care Unit, Hospital Universitario Dr. Negrín, CIBERES, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
Jordi
J
Solé-Violán
Research Unit, Hospital Universitario de Canarias, Ofra, s/n, 38320, La Laguna, Santa Cruz de Tenerife, Spain.
Alejandro
A
Jiménez
Cerebral infarction; Ischemic stroke; Mortality; Patients; Total antioxidant capacity