Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis.
OBJECTIVE
(1)H NMR-metabolomic approach was used to investigate QTc interval correlation with plasma metabolic profiles in shiftworkers.


METHODS
Socio-demographic data, electrocardiographic QTc interval and plasma metabolic profiles from 32 male shiftworkers, were correlated by multivariate regression analysis.


RESULTS
We found a positive correlation between QTc interval values, body mass index, glycemia and lactate level and a negative correlation between QTc interval and both pyroglutamate and 3-hydroxybutyrate plasma level.


CONCLUSIONS
Our analysis provides evidence of the association between clinical, metabolic profiles and QTc interval values. This could be used to identify markers of early effects and/or susceptibility in shiftworkers.
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Marcello
M
Campagna
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Emanuela
E
Locci
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Roberto
R
Piras
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Antonio
A
Noto
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Luigi Isaia
LI
Lecca
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Ilaria
I
Pilia
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Pierluigi
P
Cocco
a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Ernesto
E
d'Aloja
b Department of Chemical and Geological Sciences , University of Cagliari , Cagliari , Italy.
Paola
P
Scano
D004562:Electrocardiography; D006801:Humans; D008133:Long QT Syndrome; D008297:Male; D055432:Metabolomics; D016272:Occupational Health; D012044:Regression Analysis; D014940:Work Schedule Tolerance / Q000502:physiology*
Metabolomics; QT prolongation; shiftwork