Synthesis and Antiviral Bioassay of New Diphenyl Ether-based Compounds.
A set of diphenyl ether derivatives bearing different heterocycles were synthesized from 4-phenoxybenzohydrazide 1 in good yield. Synthesized compounds were screened against a broad panel of viruses in different cell cultures and some of the synthesized compounds showed promising antiviral properties.
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Tarek S
TS
Ibrahim
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Amany M M
AM
Al-Mahmoudy
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, 22516, Egypt.
Mohamed
M
Elagawany
Department of Pharmaceutical Chemistry, College of Pharmacy, Almaarefa Colleges for Science and Technology, Riyadh, 11597, Saudi Arabia.|Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, 6th of October, P.O. Box: 77, Giza, Egypt.
Mohamed A
MA
Ibrahim
Department of Chemistry & Physics, Augusta University, Augusta, GA, 30912, USA. sspanda12@gmail.com.
Siva S
SS
Panda
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001681:Biological Assay; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004986:Ether / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D014780:Viruses / Q000187:drug effects*
C532853:3-(5-((6-amino-1H-pyrazolo(3,4-b)pyridine-3-yl)methoxy)-2-chlorophenoxy)-5-chlorobenzonitrile; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D011720:Pyrazoles; D011725:Pyridines; D004986:Ether
antiviral; chemical biology; diphenyl ethers; drug discovery; heterocycles