Interleukin-12 (-1188) A/C and interferon-γ (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients.
The two polymorphisms [IL-12 (-1188) A/C and the IFN-γ (+874) A/T)] are known to have functional consequences and henceforth were analyzed in subacute sclerosing panencephalitis (SSPE) patients to reveal a possible relation with these polymorphisms and this debilitating disease. For the IL-12 (-1188) A/C polymorphism, 78 patients and 90 healthy individuals were analyzed. An increase in the AA genotype was determined (p = 0.02, OR = 2.06). There was also a statistically significant difference between the control group and the patients with respect to the allele frequencies (p = 0.04, OR = 1.65). For the IFN-γ (+874) A/T polymorphism, 69 SSPE patients and 115 controls were studied and there was not a significant difference between the two groups. Our findings suggested that not the IFN-γ (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with SSPE and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.
Department of Pediatric Neurology, Katip Çelebi University, Izmir, Turkey. nodundar@gmail.com.
Nihal Olgac
NO
Dundar
Department of Pediatric Neurology, Tepecik Training of Research Hospital, Izmir, Turkey.
Pinar
P
Gencpinar
Akdeniz University Health Sciences Research Centre, Akdeniz University, Antalya, Turkey.
Nilgun
N
Sallakci
Department of Pediatric Neurology, Akdeniz University, Antalya, Turkey.
Ozgur
O
Duman
Department of Pediatric Neurology, Akdeniz University, Antalya, Turkey.
Senay
S
Haspolat
Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey.
Banu
B
Anlar
Department of Pediatric Immunology, Akdeniz University, Antalya, Turkey.
Olcay
O
Yegin
D000483:Alleles; D016022:Case-Control Studies; D015870:Gene Expression; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics* / Q000276:immunology; D018664:Interleukin-12 / Q000235:genetics* / Q000276:immunology; D008459:Measles virus / Q000276:immunology / Q000472:pathogenicity*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D065840:Protective Factors; D013344:Subacute Sclerosing Panencephalitis / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000821:virology
C573415:IFNG protein, human; D018664:Interleukin-12; D007371:Interferon-gamma
Gene polymorphism; IFN-γ; IL-12; SSPE; Subacute sclerosing panencephalitis