Inflammation and endometriosis.
Endometriosis is defined by presence of endometrial glands and stroma outside the uterine cavity and it affects approximately 5%-10% of women of reproductive age. Although endometriosis is usually considered to be due to retrograde menstruation, the true pathogenesis of this disease remains poorly understood. Endometriosis is associated with an inflammatory response and this inflammation leads to endothelial dysfunction and might even lead to carcinogenesis. Here, we review our current understanding of the role of inflammatory processes in the pathogenesis of endometriosis.
Department of Obstetrics and Gynecology, Zhou Pu Hospital, Shanghai, China.
Lingli
L
Jiang
Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Shanghai 200040, China.
Yan
Y
Yan
Department of Obstetrics and Gynecology, Zhou Pu Hospital, Shanghai, China, zpyyfck@yeah.net.
Zhou
Z
Liu
Department of Obstetrics and Gynecology, Zhou Pu Hospital, Shanghai, China.
Ying
Y
Wang
D000818:Animals; D018946:Chemokine CCL5 / Q000276:immunology; D004715:Endometriosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D016176:T-Lymphocyte Subsets / Q000276:immunology
C483024:CCL5 protein, human; D018946:Chemokine CCL5