Palladium-Catalyzed Room-Temperature Acylative Suzuki Coupling of High-Order Aryl Borons with Carboxylic Acids.
This note describes a dimethyl dicarbonate-assisted, Pd(OAc)2/PPh3-catalyzed acylative Suzuki coupling of carboxylic acids with diarylborinic acids or tetraarylboronates for practical and efficient synthesis of sterically undemanding aryl ketones at room temperature. More than just cost-effective alternatives to aryl boronic acids, diarylborinic acids and tetraarylboronates displayed higher reactivity in the acylative Suzuki coupling. A variety of alkyl aryl ketones, including those bearing a hydroxy, bromo, or carbonyl group, could be readily obtained in modest to excellent yields.
Department of Fine Chemicals, East China University of Science & Technology , 130 Meilong Road, Shanghai, China.
Shufen
S
Si
Department of Fine Chemicals, East China University of Science & Technology , 130 Meilong Road, Shanghai, China.
Chen
C
Wang
Department of Fine Chemicals, East China University of Science & Technology , 130 Meilong Road, Shanghai, China.
Nan
N
Zhang
Department of Fine Chemicals, East China University of Science & Technology , 130 Meilong Road, Shanghai, China.
Gang
G
Zou