Magnetic Resonance Imaging Abnormalities in Advanced Acute Bilirubin Encephalopathy Highlight Dentato-Thalamo-Cortical Pathways.
A distinct pattern of acute restricted diffusion on magnetic resonance imaging localized to key regions within the dentato-thalamo-cortical pathway was observed early in a term newborn during advanced stages of acute bilirubin encephalopathy. These findings demonstrate that vulnerability to bilirubin toxicity extends across specific neuroanatomic tracts.
Department of Pediatric Radiology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA.
Jessica L
JL
Wisnowski
Department of Pediatric Radiology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Ashok
A
Panigrahy
Division of Pediatric Neurology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Michael J
MJ
Painter
Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address: jwatchko@mail.magee.edu.
Jon F
JF
Watchko
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007647:Kernicterus / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy
Rh hemolytic disease; apparent diffusion coefficient; cerebellum; diffusion weighted imaging; hyperbilirubinemia; kernicterus