Eph-ephrin signaling in nervous system development.
Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate how these proteins interact with each other, and with other signaling pathways, to guide specificity in a diverse set of developmental processes.
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Karina S
KS
Cramer
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Ilona J
IJ
Miko
Axon guidance; Eph receptors; Ephrins; nervous system development; neuronal migration