Copper-Based Nanomaterials for Cancer Imaging and Therapy.
Copper based nanoparticles (NPs) have attracted increased attention for biomedical applications. Copper chalcogenide NPs exhibit strong absorption in near-infrared region, demonstrate highly efficient light-to-heat transformation under near-infrared laser irradiation, and cause selective thermal destruction to the tumor. Smaller copper NPs display fluorescence signal and capability for optical imaging. Copper based NPs also serve as a versatile vehicle for drug delivery and image-guided therapy. This review covers recent advances related to the biomedical application of copper based NPs, with a focus on cancer imaging and therapy. We also discuss challenges to their successful clinical translation.
Departments of Cancer Systems Imaging The University of Texas M. D. Anderson Cancer Center 1881 East Road, Houston, Texas 77054, United States.|PET center, Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310009, China.|Institute of Translational Medicine, Zhejiang University , Hangzhou, Zhejiang 310009, China.
Min
M
Zhou
PET center, Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310009, China.
Mei
M
Tian
Departments of Cancer Systems Imaging The University of Texas M. D. Anderson Cancer Center 1881 East Road, Houston, Texas 77054, United States.
Chun
C
Li
D000818:Animals; D003300:Copper / Q000737:chemistry* / Q000627:therapeutic use* / Q000633:toxicity; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*
D003300:Copper