Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: Evidence from 7,290 cases and 11,630 controls.
Published data on the association between the coiled-coil domain-containing 26 (CCDC26) rs4295627 polymorphism and the risk of glioma have been inconclusive. To further investigate this association, a meta-analysis was performed. By a comprehensive literature search using PubMed and EMBASE databases, a total of 16 case-control studies were identified for inclusion in the meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess this association. Our results confirmed that the risk with allele G was higher compared with that with allele T for glioma. The results indicated that the allele G of rs4295627 polymorphism in the CCDC26 gene was associated with increased risk of glioma in the homozygote model (GG vs. TT, OR=1.936, 95 %CI: 1.500-2.658, P<0.001), the heterozygote model (GT vs. TT, OR=1.323, 95% CI: 1.241-1.412, P=0.206), the dominant model (GG+GT vs. TT, OR=1.375, 95% CI: 1.256-1.505, P=0.026), the recessive model (GG vs. GT+TT, OR=1.769, 95% CI: 1.302-2.403, P<0.001) and the allele model (G vs. T, OR=1.310, 95% CI: 1.185-1.448, P<0.001). Current evidence suggests that the rs4295627 polymorphism in the CCDC26 gene may contribute to glioma susceptibility. However, further case-control studies are required to confirm our results.
Department of Nephrology, Jining Hospital of Traditional Chinese Medicine, Jining, Shandong 272037, P.R. China.
Xiangsheng
X
Wang
Department of Neurology, Jining Hospital of Traditional Chinese Medicine, Jining, Shandong 272037, P.R. China.
Tong
T
Luo
Department of Neurology, Jining Hospital of Traditional Chinese Medicine, Jining, Shandong 272037, P.R. China.
Mingjun
M
Ruan
Department of Stomatology, Laiwu Laicheng People's Hospital, Laiwu, Shandong 271199, P.R. China.
Pan
P
Liu
Department of Oncology, Laiwu Hospital of Traditional Chinese Medicine, Laiwu, Shandong 271199, P.R. China.
Shiying
S
Wang
Department of Neurology, Zibo Hospital of Traditional Chinese Medicine, Zibo, Shandong 255300, P.R. China.
Wenhao
W
Zhu
coiled-coil domain-containing 26; glioma; meta-analysis; polymorphism