LncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats mediated by P2X7 receptor in SCG.
Diabetic autonomic neuropathy includes the sympathetic ganglionic dysfunction. P2X7 receptor in superior cervical ganglia (SCG) participated in the pathological changes of cardiac dysfunction. Abnormal expression of long noncoding RNAs (lncRNAs) was reported to be involved in nervous system diseases. Our preliminary results obtained from rat lncRNA array profiling revealed that the expression of the uc.48+ was significantly increased in the rat SCG in response to diabetic sympathetic pathology. In this study, we found that lncRNAuc.48+ and P2X7 receptor in the SCG were increased in type 2 diabetic rats and were associated with the cardiac dysfunction. The uc.48+ small interference RNA (siRNA) improved the cardiac autonomic dysfunction and decreased the up-regulation P2X7 and the ratio of phosphorylated extracellular regulated protein kinases1/2 (p-ERK1/2) to ERK1/2 in SCG of type 2 diabetic rats. In conclusion, lncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats through regulating the expression of P2X7 and ERK signaling in SCG.
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Bing
B
Wu
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Chunping
C
Zhang
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Lifang
L
Zou
Undergraduate student of Class 131 of Queen Mary School, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Yucheng
Y
Ma
Undergraduate student of Class 131 of Queen Mary School, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Kangyu
K
Huang
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Qiulan
Q
Lv
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Xi
X
Zhang
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Shouyu
S
Wang
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Yun
Y
Xue
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Zhihua
Z
Yi
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Tianyu
T
Jia
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Shanhong
S
Zhao
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Shuangmei
S
Liu
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Hong
H
Xu
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China. Electronic address: li.guilin@163.com.
Guilin
G
Li
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China. Electronic address: liangsd@hotmail.com.
Shangdong
S
Liang
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D005728:Ganglia, Sympathetic / Q000378:metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D058486:Receptors, Purinergic P2X7 / Q000235:genetics / Q000378:metabolism*; D017783:Superior Cervical Ganglion / Q000378:metabolism*
D062085:RNA, Long Noncoding; D034741:RNA, Small Interfering; D058486:Receptors, Purinergic P2X7
Long noncoding RNA; P2X(7) receptor; Superior cervical ganglia; Type 2 diabetes