Laparoscopic Pancreatoduodenectomy in 50 Consecutive Patients with No Mortality: A Single-Center Experience.
BACKGROUND
Laparoscopic pancreatic surgery has gradually expanded to include pancreatoduodenectomy (PD). This study presents data regarding the efficacy of laparoscopic PD in a single center.


METHODS
This was a single-cohort, prospective observational study. From March 2012 to September 2015, 50 consecutive patients underwent laparoscopic PD using a five-trocar technique. Reconstruction of the digestive tract was performed with double jejunal loop technique whenever feasible. Patients with radiological signs of portal vein invasion were operated by open approach.


RESULTS
Twenty-seven women and 23 men with a median age of 63 years (range 23-76) underwent laparoscopic PD. Five patients underwent total pancreatectomy. All, but 1 patient (previous bariatric operation), underwent pylorus-preserving resection. Reconstruction was performed with double jejunal loop in all cases except in 5 cases of total pancreatectomy. Conversion was required in 3 patients (6%) as a result of difficult dissection (two cases) and unsuspected portal vein invasion (1 patient). Median operative time was 420 minutes (range 360-660), and the 90-day mortality was nil. Pancreatic fistula occurred in 13 patients (26%). There was one grade C (reoperated), one grade B (percutaneous drainage), and all remaining were grade A (conservative treatment). Other complications included port site bleeding (n = 1), biliary fistula (n = 2), and delayed gastric emptying (n = 2). Mean hospital stay was 8.4 days (range 5-31).


CONCLUSIONS
Laparoscopic PD is feasible and safe, but is technically demanding and may be reserved to highly skilled laparoscopic surgeons with proper training in high-volume centers. Isolated pancreatic anastomosis may be useful to decrease the severity of postoperative pancreatic fistulas. Therefore, it could be a good option in patients with a high risk for developing postoperative pancreatic, as well as by less-experienced surgeons.
1 Department of Surgery, University of São Paulo , São Paulo, Brazil .|2 Sírio Libanês Hospital , São Paulo, Brazil .
Marcel Autran C
MA
Machado
2 Sírio Libanês Hospital , São Paulo, Brazil .
Rodrigo C
RC
Surjan
2 Sírio Libanês Hospital , São Paulo, Brazil .
Tiago
T
Basseres
2 Sírio Libanês Hospital , São Paulo, Brazil .
Izabella B
IB
Silva
1 Department of Surgery, University of São Paulo , São Paulo, Brazil .|2 Sírio Libanês Hospital , São Paulo, Brazil .
Fábio F
FF
Makdissi
D000328:Adult; D000368:Aged; D001658:Biliary Fistula / Q000209:etiology*; D061887:Conversion to Open Surgery; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D010180:Pancreatectomy / Q000379:methods; D010185:Pancreatic Fistula / Q000209:etiology*; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D019106:Postoperative Hemorrhage / Q000209:etiology; D011446:Prospective Studies; D015996:Survival Rate; D055815:Young Adult