[Mechanism of cardiac atrophy under weightlessness/simulated weightlessness].
Cardiac remodeling is the heart's response to external or internal stimuli. Weightlessness/simulated weightlessness leads to cardiac atrophy and heart function declining. Understanding the mechanism of cardiac atrophy under weightlessness is important to help astronaut recover from unloading-induced cardiovascular changes after spaceflight. Unloading-induced changes of hemodynamics, metabolic demands and neurohumoral regulation contribute to cardiac atrophy and function declining. During this process, Ca(2+)-related signaling, NF-κB signaling, ERK signaling, ubiquitin-proteasome pathway and autophagy are involved in weightlessness-induced cardiac atrophy. This article reviews the underlying mechanism of cardiac atrophy under weightlessness/simulated weightlessness.
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China.
Guo-Hui
GH
Zhong
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China.
Shu-Kuan
SK
Ling
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China. yingxianli@aliyun.com.
Ying-Xian
YX
Li
D001284:Atrophy; D006321:Heart; D006331:Heart Diseases; D006439:Hemodynamics; D006801:Humans; D016328:NF-kappa B; D013026:Space Flight; D014893:Weightlessness; D018474:Weightlessness Simulation
D016328:NF-kappa B