Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer.
Breast cancer is a serious threat to women's health, because multidrug resistance (MDR) has hampered treatment and prognosis. Nanodelivery of anticancer agents is a new technology to be exploited in the treatment of patients, because it bypasses multispecific drug efflux transporters such as P-glycoprotein (ABCB1), multidrug resistance protein-1 (MRP1, ABCC1) and breast cancer resistance protein (BCRP, ABCG2). Drugs can be delivered to tumor tissue by passive and active tumor targeting strategies, which may reduce or reverse drug resistance. This review will mainly focus on MDR-associated proteins, as well as various nanoparticle formulations developed to overcome MDR in breast cancer.
a College of Pharmacy, Jinan University , Guangzhou , P. R. China.
Yueling
Y
Yuan
b College of Life Science, Liaoning University , Shenyang , P. R. China.
Tiange
T
Cai
a College of Pharmacy, Jinan University , Guangzhou , P. R. China.
Xi
X
Xia
a College of Pharmacy, Jinan University , Guangzhou , P. R. China.
Ronghua
R
Zhang
c Medical University of Vienna , Vienna , Austria , and.
Peter
P
Chiba
a College of Pharmacy, Jinan University , Guangzhou , P. R. China.|d Cancer Research Institute of Jinan University , Guangzhou , P. R. China.
Yu
Y
Cai
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*
D000970:Antineoplastic Agents; D027425:ATP-Binding Cassette, Sub-Family C Proteins
Breast cancer; mechanisms; multidrug resistance; nanoparticles