Impact of Admission Glucose on Non-Diabetic Patients with ST-Segment Elevation Myocardial Infarction Treated with Percutaneous Coronary Intervention: A Meta-Analysis.
BACKGROUND
Impaired admission glucose (AG) is thought to significantly increase the risk of both early and late death with ST-segment elevation myocardial infarction (STEMI), especially for non-diabetic patients. However, several earlier studies contradict these relationships. Through our meta-analysis, we aimed to evaluate such a relation between impaired AG, the risk of death and STEMI.


METHODS
We accessed PubMed, EMBASE, Web of Science, and the Cochrane Library and systematically searched their databases to identify all related prospective cohort studies. The relative risks (RRs) with their 95% confidence interval (CI) were pooled quantitatively.


RESULTS
The pooled, unadjusted relative risks of early outcome events indicated that patients who had glucose concentrations ≥ the range of 6.1-11.1 mmol/L, had a 4.38-fold (95% CI, 3.23-5.94) higher early mortality. For late outcome events, the pooled unadjusted RR indicated patients who had glucose concentrations ≥ the range 7.8-11.1 mmol/L, and had a 2.69-fold (95% CI, 2.16-3.34) higher late mortality based on full participants, whereas patients had a 1.65-fold (95% CI, 1.33-2.04) higher late mortality based on based on in-hospital or 30-day survivors.


CONCLUSIONS
In conclusion, the present meta-analysis demonstrated that impaired admission glucose may be an effective prognostic marker for significantly increased risk of early death. Regarding the long-term outcomes based on full population or early survival, high admission glucose also has a distinct but poorer prognostic impact on long-term mortality than early mortality.


BACKGROUND
Admission glucose • Meta-analysis • Myocardial infarction • Non-diabetic.
Department of Cardiology, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou 450000, China.
Zhen-Xuan
ZX
Hao
Department of Cardiology, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou 450000, China.
Yang
Y
Liu
Department of Cardiology, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou 450000, China.
Dan-Li
DL
Wang
Department of Cardiology, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou 450000, China.
Wen-Jie
WJ
Han
Department of Cardiology, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou 450000, China.
Lei
L
Wu
Department of Cardiology, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou 450000, China.
Heng-Liang
HL
Liu