A comparative study between propofol and etomidate in patients under general anesthesia.
OBJECTIVE
Induction of anesthesia is a critical part of anesthesia practice. Sudden hypotension, arrhythmias, and cardiovascular collapse are threatening complications following injection of induction agent in hemodynamically unstable patients. It is desirable to use a safe agent with fewer adverse effects for this purpose. Present prospective randomized study is designed to compare propofol and etomidate for their effect on hemodynamics and various adverse effects on patients in general anesthesia.


METHODS
Hundred ASA I and II patients of age group 18-60 years scheduled for elective surgical procedure under general anesthesia were randomly divided into two groups of 50 each receiving propofol (2mg/kg) and etomidate (0.3mg/kg) as an induction agent. Vital parameters at induction, laryngoscopy and thereafter recorded for comparison. Adverse effect viz. pain on injection, apnea and myoclonus were carefully watched.


RESULTS
Demographic variables were comparable in both the groups. Patients in etomidate group showed little change in mean arterial pressure (MAP) and heart rate (HR) compared to propofol (p>0.05) from baseline value. Pain on injection was more in propofol group while myoclonus activity was higher in etomidate group.


CONCLUSIONS
This study concludes that etomidate is a better agent for induction than propofol in view of hemodynamic stability and less pain on injection.
Department of Anesthesia and Critical care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
Supriya
S
Aggarwal
Department of Anesthesia and Critical care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India. Electronic address: dr.vipin28@gmail.com.
Vipin Kumar
VK
Goyal
Department of Anesthesia and Critical care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
Shashi Kala
SK
Chaturvedi
Department of Anesthesia and Critical care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
Vijay
V
Mathur
Department of Anesthesia and Critical care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
Birbal
B
Baj
Department of Anesthesia and Critical care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
Alok
A
Kumar
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005045:Etomidate / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D055815:Young Adult
D018686:Anesthetics, Intravenous; D015742:Propofol; D005045:Etomidate
Estabilidade hemodinâmica; Hemodynamic stability; Induction of anesthesia; Indução da anestesia; Mean arterial pressure; Mioclonia; Myoclonus; Pressão arterial média; Propofol