Factor XI deficiency and aortic valve replacement: Perioperative management.
Severe factor XI deficiency (hemophilia C) is a rare coagulation disorder. A 73-year-old woman, a homozygote for factor XI deficiency, required aortic valve replacement. An initial dose of 15 U kg-1of factor XI concentrate was administered preoperatively and on postoperative day 3. During surgery, concentrated red cells, fresh frozen plasma, platelets, tranexamic acid, and fibrinogen were transfused. Intraoperative bleeding and total chest drainage were minimal. Postoperatively, there was no need for further transfusions and no bleeding or thrombotic complications occurred. The patient was well 16 months after surgery.
1 Cardiac Surgery ICU, University Hospital of Heraklion, Crete, Greece.
Aristea
A
Petroulaki
2 Cardiac Surgery Department, University Hospital of Heraklion, Crete, Greece.
George
G
Lazopoulos
3 Anaesthesiology Department, University Hospital of Heraklion, Crete, Greece.
Fotini
F
Chaniotaki
2 Cardiac Surgery Department, University Hospital of Heraklion, Crete, Greece.
Emmanuel
E
Kampitakis
2 Cardiac Surgery Department, University Hospital of Heraklion, Crete, Greece.
Dionysis
D
Pavlopoulos
2 Cardiac Surgery Department, University Hospital of Heraklion, Crete, Greece.
George
G
Chalkiadakis
D000368:Aged; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D001021:Aortic Valve / Q000601:surgery*; D001777:Blood Coagulation / Q000187:drug effects*; D016913:Blood Component Transfusion; D017707:Erythrocyte Transfusion; D005173:Factor XI Deficiency / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005340:Fibrinogen / Q000008:administration & dosage*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D007430:Intraoperative Care; D010949:Plasma; D017713:Platelet Transfusion; D014148:Tranexamic Acid / Q000008:administration & dosage*; D016896:Treatment Outcome
D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid; D005340:Fibrinogen
Aortic valve insufficiency; Blood loss; Factor XI deficiency; Heart valve prosthesis implantation; surgical