Hashimoto's Thyroiditis in South Indian Centre.
OBJECTIVE
To describe the clinical and investigatory profile of children with Hashimoto's thyroiditis (HT) presenting to the thyroid clinic of a referral children's hospital and study the course of children diagnosed as HT over a period of 6 mo.


METHODS
Children aged 5-12 y with HT were recruited, their clinical and biochemical details were assessed and were started on standard therapy and followed up for a period of 6 mo.


RESULTS
Ninety-seven children (89 goitrous and 8 atrophic form) with mean age: 9.90 ± 1.76 y; M:F 1:5.4 were recruited; 55.7 % were asymptomatic;14.2 % had familial clustering. The mean height, weight and BMI for age Z-scores were -1.0 ± 1.0, -0.8 ± 0.9 and -0.5 ± 1.1 respectively. 16.4 % had short stature; 4.1 % had obesity; 72.2 % had grade 2 goitre. 73.4 %, 13.2 %, 10.3 % and 3.1 % had overt hypothyroidism, sub-clinical hypothyroidism, euthyroidism and hyperthyroidism, respectively. On follow up, 38.5 % of euthyroid and 80 % of sub-clinical hypothyroid children developed overt hypothyroidism. Thyrotoxic symptoms resolved in all three Hashitoxic children by 6 mo.


CONCLUSIONS
A female preponderance, less familial clustering, higher paucity of clinical manifestations and quick progression to hypothyroidism (in those without) were noted in the present series.
Department of Pediatrics, St Anthony Hospital, Chennai, Tamil Nadu, India.
Ramya
R
Rajamanickam
Department of Pediatrics, Stanley Medical College, Chennai, Tamil Nadu, India.
Lakshmi
L
Shanmugavelu
Department of Pediatrics, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu, India.
Sundari
S
Subramanian
Department of Pediatric Endocrinology, Dr. Mehta's Children's Hospital, 2 Mc Nichols Road, Chetpet, Chennai 31, Tamil Nadu, India. pediatricendocrinology.mehta@gmail.com.
Hemchand Krishna
HK
Prasad
Dr. Mehta's Children's Hospital, Chennai, Tamil Nadu, India.
Nedunchelian
N
Krishnamoorthy
D002648:Child; D004392:Dwarfism; D005260:Female; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D006980:Hyperthyroidism; D007037:Hypothyroidism; D008297:Male
Hashimotos; Hypothyroidism; Thyroiditis