Grafting of Expanded Mesenchymal Stem Cells without Associated Procedure in a Healed Case of Ulna Pseudarthrosis: A Case Report.
BACKGROUND
The surgical management of pseudoarthrosis is often a challenge. The use of mesenchymal multipotent cells expanded and manipulated in the laboratory is an interesting treatment of pseudoarthrosis, because they can lead to differentiation into osteocytes and thus the formation of bone tissue.


METHODS
We present a case of a 47-years-old man with isolate ulna fracture, treated with plate and screws and evolved in non-union. The patient underwent an expanded stem cells graft on the site of non-union with a small incision of approximately 3cm, without changing the synthesis system. After one year, the X-ray showed a complete fracture consolidation.


CONCLUSIONS
In our opinion, this case is interesting because it highlights the cellular action that is the only healing factor; it is an important demonstration of the biological action of expanded mesenchymal stem cells (MSCs).


CONCLUSIONS
To validate the use of MSCs, it is necessary to perform comparative studies for age, sex, general condition, location, and mechanism of injury as a further clinical validation of the efficiency of this cell line.
Department of Orthopedic and Traumatology, University of Pisa, Pisa, Italy.
Giacomo
G
Dell'Osso
Department of Orthopedic and Traumatology, University of Pisa, Pisa, Italy.
Giulia
G
Bugelli
Department of Orthopedic and Traumatology, University of Pisa, Pisa, Italy.
Fabio
F
Celli
Hematology Division, Department of Oncology, University of Pisa, Pisa, Italy.
Mario
M
Petrini
Hematology Division, Department of Oncology, University of Pisa, Pisa, Italy.
Luisa
L
Trombi
Department of Orthopedic and Traumatology, University of Pisa, Pisa, Italy.
Giulio
G
Guido
Department of Orthopedic and Traumatology, University of Pisa, Pisa, Italy.
Stefano
S
Giannotti
D003131:Combined Modality Therapy / Q000295:instrumentation / Q000379:methods; D005593:Fracture Fixation, Internal / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D008875:Middle Aged; D011542:Pseudarthrosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy*; D023822:Tissue Engineering / Q000379:methods; D016896:Treatment Outcome; D014458:Ulna Fractures / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*