Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.
In the central nervous system, most excitatory post-synapses are small subcellular structures called dendritic spines. Their structure and morphological remodeling are tightly coupled to changes in synaptic transmission. The F-actin cytoskeleton is the main driving force of dendritic spine remodeling and sustains synaptic plasticity. It is therefore essential to understand how changes in synaptic transmission can regulate the organization and dynamics of actin binding proteins (ABPs). In this review, we will provide a detailed description of the organization and dynamics of F-actin and ABPs in dendritic spines and will discuss the current models explaining how the actin cytoskeleton sustains both structural and functional synaptic plasticity.
Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, 33000, Bordeaux, France.|Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, 33000, Bordeaux, France.|Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
Anaël
A
Chazeau
Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, 33000, Bordeaux, France. gregory.giannone@u-bordeaux.fr.|Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, 33000, Bordeaux, France. gregory.giannone@u-bordeaux.fr.
Grégory
G
Giannone
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D049229:Dendritic Spines / Q000502:physiology*; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
D000199:Actins; D008840:Microfilament Proteins
Actin binding proteins; Actin cytoskeleton; CAMKII; Dendritic spines; PSD; Super-resolution microscopy; Synaptic plasticity