Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people.
OBJECTIVE
This study was carried out to determine whether changes in hemorheological parameters parallel the severity of essential hypertension.


METHODS
A total of 198 older hypertensive patients were recruited and classified into 3 stages of hypertension according to the grading standard of hypertension. The whole blood viscosity (WBV) at various shear rates, plasma viscosity and erythrocyte rheology (including erythrocyte rigidity index, erythrocyte aggregation index and erythrocyte deformation index) were examined.


RESULTS
Erythrocyte rheology paralleled the severity of essential hypertension and was significantly correlated to the average 24 h systolic blood pressure and diastolic blood pressure. Logistic analysis revealed that erythrocyte rigidity and the erythrocyte aggregation index were positively correlated with the severity of hypertension, while the erythrocyte deformation index was negatively correlated. No association was found between WBV, plasma viscosity and the severity of hypertension.


CONCLUSIONS
The rheological properties of erythrocyte viscosity were correlated with the severity of hypertension in older people but the WBV and plasma viscosity were not.
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China.
Guo-Xiang
GX
Fu
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China.
Min
M
Ji
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China.
Li-Zhi
LZ
Han
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China.
Chan-Chan
CC
Xu
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China.
Feng-Feng
FF
Pan
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China.
Ting-Jun
TJ
Hu
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China. zhongyuan60@126.com.
Yuan
Y
Zhong
D000369:Aged, 80 and over; D001809:Blood Viscosity; D004907:Erythrocyte Deformability; D004912:Erythrocytes; D000075222:Essential Hypertension / Q000097:blood* / Q000145:classification / Q000175:diagnosis*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D006403:Hematologic Tests / Q000379:methods; D006801:Humans; D008297:Male; D010949:Plasma; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
Aged; Blood pressure; Blood viscosity; Erythrocyte deformability; Vascular resistance