The Commonalities in Bacterial Effector Inhibition of Apoptosis.
Antiapoptotic pathways of the host cell play integral roles in bacterial pathogenesis, with inhibition of those pathways resulting in halted disease pathology. Certain pathogens have developed elegant mechanisms to modulate the fate of the host cell, many of which target novel pathways that are poorly understood in the context of the cell biology. Bacterial pathogenesis research not only promotes the understanding of the role of antiapoptotic pathways in bacterial infection, but has a broader context in understanding the epitome of human disease, that is, developing the understanding of tumorigenic or inflammatory pathways. Here we review host antiapoptotic signalling pathways manipulated by translocated bacterial effectors that propagate the disease state, drawing common parallels and showing the novel differences.
Department of Life Science, Imperial College London, London, UK. Electronic address: scott.robinson08@alumni.imperial.ac.uk.
Keith S
KS
Robinson
Department of Life Science, Imperial College London, London, UK.
Rochelle
R
Aw
D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001419:Bacteria / Q000378:metabolism / Q000472:pathogenicity; D001424:Bacterial Infections / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction
D001426:Bacterial Proteins; D016328:NF-kappa B; D020929:Mitogen-Activated Protein Kinase Kinases
Akt; NF-κB; apoptosis; bacterial pathogenesis; effector proteins