[Hypoxia as functional base of metabolic processes changes in erythrocytes and hepatocytes of rats after prolonged Simvastatin (Zokor) intake].
Concentration of glycolysis metabolites, activity of enzymes of carbohydrate and energetic metabolism and antioxidant enzymes was investigated in hepatocytes and erythrocytes with the purpose of estimation of functional metabolic changes of cells rebuilding after prolonged Simvastatin intake (Zocor, 20 mg; on 1.5 mg once a day during 3 months). It was established that total metabolic reaction on prolonged Simvastatin intake at intact animals characterized by hypoxia formation, that manifested by increasing of 2.3-BPG concentration in erythrocytes, lactate accumulation in erythrocytes and hepatocytes. Different side changes of glutathione-dependent enzymes activity, activation of first line of antioxidant defense enzymes testify about tense defense mechanisms of erythrocytes and hepatocytes. Biochemical changes in blood plasma shows tendency to cytolysis syndrome formation and affection of biosynthetic liver function. Decreasing of ceruloplasmin concentration can be used as additional biochemical test in estimation of the state of liver affection at prolonged Simvastatin intake.
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Belousova
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Mikashinowich
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Sarkysjan
D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects; D002570:Ceruloplasmin / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D051381:Rats; D019821:Simvastatin / Q000009:adverse effects* / Q000494:pharmacology
D019344:Lactic Acid; D019821:Simvastatin; D002570:Ceruloplasmin