Enhanced biocompatibility and antibacterial property of polyurethane materials modified with citric acid and chitosan.
Citric acid (CA) and chitosan (CS) were covalently immobilized on polyurethane (PU) materials to improve the biocompatibility and antibacterial property. The polyurethane pre-polymer with isocyanate group was synthesized by one pot method, and then grafted with citric acid, followed by blending with polyethersulfone (PES) to prepare the blend membrane by phase-inversion method so that chitosan can be grafted from the membrane via esterification and acylation reactions eventually. The native and modified membranes were characterized by attenuated total reflectance-Fourier transform infrared spectroscope, X-ray photoelectron spectroscopy, scanning electron microscopy, water contact angle measurement, and tensile strength test. Protein adsorption, platelet adhesion, hemolysis assay, activated partial thromboplastin time, prothrombin time, thrombin time, and adsorption of Ca(2+) were executed to evaluate the blood compatibility of the membranes decorated by CA and CS. Particularly, the antibacterial activities on the modified membranes were evaluated based on a vitro antibacterial test. It could be concluded that the modified membrane had good anticoagulant property and antibacterial property.
a College of Chemistry and Chemical Engineering , Central South University , Changsha , P. R. China.
Tian-Ming
TM
Liu
a College of Chemistry and Chemical Engineering , Central South University , Changsha , P. R. China.
Xing-Ze
XZ
Wu
a College of Chemistry and Chemical Engineering , Central South University , Changsha , P. R. China.
Yun-Ren
YR
Qiu
D000328:Adult; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D019343:Citric Acid / Q000737:chemistry* / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D010973:Platelet Adhesiveness / Q000187:drug effects; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011140:Polyurethanes; D019343:Citric Acid; D048271:Chitosan
Polyurethane; antibacterial property; biocompatibility; chitosan; citric acid; membrane; phase-inversion; polyethersulfone