Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes.
Three extractable polysaccharides including Ac-RPS, Al-RPS and En-RPS were extracted from the residue of Flammulina velutipes and their antioxidative and renoprotective effects on STZ-induced mice were investigated. Biochemical and antioxidant analysis showed that the En-RPS had potential effects in decreasing the serum levels of CRE, BUN, ALB and GLU significantly, increasing the renal activities of SOD, CAT and GSH-Px remarkably, and reducing the renal contents of MDA prominently. Furthermore, the histopathological observations also displayed that En-RPS could alleviate kidney damage. These results demonstrated that En-RPS extracted from the residue of F. velutipes possessed potent antioxidant activities, and could be used as a promising therapeutic agent for inhibiting the progression of diabetic nephropathy. In addition, the monosaccharide compositions of these three RPS were also analyzed.
College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
Lin
L
Lin
College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
Fangyuan
F
Cui
College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
Jianjun
J
Zhang
Shandong Agricultural Technology Extending Station, Ji'nan, Shandong 250100, PR China.
Xia
X
Gao
Quality and Safety Monitoring Center of Animal Products, Ji'nan, Shandong 250002, PR China.
Meng
M
Zhou
College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
Nuo
N
Xu
College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
Huajie
H
Zhao
College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
Min
M
Liu
College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
Chen
C
Zhang
College of Life Science, Shandong Agricultural University, Taian 271018, PR China. Electronic address: jia__le@126.com.
Le
L
Jia
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D055393:Flammulina / Q000737:chemistry*; D062610:Fungal Polysaccharides / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D008297:Male; D051379:Mice; D020011:Protective Agents / Q000494:pharmacology
D000975:Antioxidants; D062610:Fungal Polysaccharides; D020011:Protective Agents
Antioxidative effects; Diabetic nephropathy; Flammulina velutipes; Renoprotective effects; Residue polysaccharides