[Not Available].
Although dopamine replacement therapy has been used in Parkinson's disease since the 1960s, it is only recently that behavioral disorders associated with these drugs have been described. Gathered under the term "behavioral addiction", they include impulse control disorders, dopamine dysregulation syndrome (DDS), and punding. Whereas addiction per se occurs almost exclusively with levodopa, impulse control disorders appear preferentially during dopamine agonist therapy. The prevalence of these disorders is estimated to be 10-17% in Parkinson's disease, a rate far higher than in the general population. Behavioral addiction in Parkinson's disease is thus a major public health problem, notably because of its familial, social, economic and legal implications. Preventive measures, and dopaminergic drug dose reduction, are currently the best strategies for managing these disorders.
Jean-Christophe
JC
Corvol
D016739:Behavior, Addictive / Q000150:complications* / Q000523:psychology / Q000628:therapy; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000150:complications / Q000523:psychology / Q000628:therapy; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology* / Q000628:therapy; D013577:Syndrome
D004298:Dopamine