Antiviral Activity of Graphene-Silver Nanocomposites against Non-Enveloped and Enveloped Viruses.
The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. To investigate the antiviral activity of graphene oxide (GO) sheets and GO sheets with silver particles (GO-Ag) against enveloped and non-enveloped viruses, feline coronavirus (FCoV) with an envelope and infectious bursal disease virus (IBDV) without an envelope were chosen. The morphology and sizes of GO and GO-Ag were characterized by transmission, scanning electron microscopy, and X-ray diffraction. A virus inhibition assay was used to identify the antiviral activity of GO and GO-Ag. Go-Ag inhibited 25% of infection by FCoV and 23% by IBDV, whereas GO only inhibited 16% of infection by FCoV but showed no antiviral activity against the infection by IBDV. Further application of GO and GO-Ag can be considered for personal protection equipment to decrease the transmission of viruses.
Department of Bioscience Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan City 32023, Taiwan. yining@cycu.edu.tw.
Yi-Ning
YN
Chen
Graduate School of Biotechnology and Bioengineering, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan. yihhsueh@saturn.yzu.edu.tw.
Yi-Huang
YH
Hsueh
Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan. cthsieh@saturn.yzu.edu.tw.
Chien-Te
CT
Hsieh
Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan. dong1015211@gmail.com.
Dong-Ying
DY
Tzou
Division of General Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, 1492 Zhongshan Road, Taoyuan City 33004, Taiwan. patty37021@mail.tygh.gov.tw.
Pai-Ling
PL
Chang
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D018175:Birnaviridae Infections / Q000188:drug therapy* / Q000821:virology; D002371:Cat Diseases / Q000188:drug therapy / Q000821:virology; D002415:Cats; D018929:Cell Culture Techniques; D017934:Coronavirus / Q000187:drug effects*; D018352:Coronavirus Infections / Q000188:drug therapy* / Q000821:virology; D005333:Fetus; D006108:Graphite / Q000494:pharmacology; D007243:Infectious bursal disease virus / Q000187:drug effects*; D053761:Nanocomposites; D012834:Silver / Q000494:pharmacology*
D000998:Antiviral Agents; D012834:Silver; D006108:Graphite
enveloped virus; feline coronavirus; graphene oxide; infectious bursal disease virus; non-enveloped virus; silver nanoparticle