Monocytes Take Their Own Path to IL-1β.
Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus.
Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA.
Eric I
EI
Elliott
Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA; Division of Infectious Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: fayyaz.sutterwala@cshs.org.
Fayyaz S
FS
Sutterwala
D002352:Carrier Proteins / Q000378:metabolism; D020170:Caspase 1 / Q000378:metabolism*; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D002352:Carrier Proteins; D058847:Inflammasomes; D053583:Interleukin-1beta; D017382:Reactive Oxygen Species; D020170:Caspase 1