Characterization of unexplored amidohydrolase enzyme-pterin deaminase.
Pterin deaminase is an amidohydrolase enzyme hydrolyzing pteridines to form lumazine derivatives and ammonia. The enzyme captured the attention of scientists as early as 1959 and had been patented for its application as an anticancer agent. It is ubiquitously present in prokaryotes and has been reported in some eukaryotes such as honey bee, silkworm and rats. The enzyme has been observed to have a spectrum of substrates with the formation of respective lumazines. The role of the substrates of the enzyme in various metabolic pathways warrants a significant role in the biological activity of both prokaryotes and eukaryotes. Even though the functions of the enzyme have been explored in prokaryotes, their niche in the eukaryotic system is not clear. There is very few information on the structural and functional properties of the enzyme. This review has been congregated to emphasize the significance of pterin deaminase and analyzes the lacunae in understanding the biological characters of the enzyme.
Cancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, Tamilnadu, India. angaibiotech@buc.edu.in.
Angayarkanni
A
Jayaraman
Cancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, Tamilnadu, India.
Murugesan
M
Thandeeswaran
Department of Microbiology, Periyar University, Salem, 636011, Tamilnadu, India.
Ulaganathan
U
Priyadarsini
Cancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, Tamilnadu, India.
Shanmugam
S
Sabarathinam
Cancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, Tamilnadu, India.
K A Ayub
KA
Nawaz
Department of Microbiology, Karpagam University, Coimbatore, 641021, Tamilnadu, India.
Muthusamy
M
Palaniswamy
D000581:Amidohydrolases / Q000378:metabolism*; D000619:Aminohydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives / Q000378:metabolism; D005057:Eukaryotic Cells / Q000201:enzymology; D011387:Prokaryotic Cells / Q000201:enzymology; D011621:Pteridines / Q000737:chemistry
D011621:Pteridines; D001708:Biopterins; C008297:lumazine; D000581:Amidohydrolases; D000619:Aminohydrolases; C019065:pterin deaminase; C003402:sapropterin
Amidohydrolase; Anticancer agent; Deamination; Lumazine; Pteridine; Pterin deaminase