MicroRNA: a connecting road between apoptosis and cholesterol metabolism.
Resistance to apoptosis leads to tumorigenesis and failure of anti-cancer therapy. Recent studies also highlight abrogated lipid/cholesterol metabolism as one of the root causes of cancer that can lead to metastatic transformations. Cancer cells are dependent on tremendous supply of cellular cholesterol for the formation of new membranes and continuation of cell signaling. Cholesterol homeostasis network tightly regulates this metabolic need of cancer cells on cholesterol and other lipids. Genetic landscape is also shared between apoptosis and cholesterol metabolism. MicroRNAs (miRNAs) are the new fine tuners of signaling pathways and cellular processes and are known for their ability to post-transcriptionally repress gene expression in a targeted manner. This review summarizes the current knowledge about the cross talk between apoptosis and cholesterol metabolism via miRNAs. In addition, we also emphasize herein recent therapeutic modulations of specific miRNAs and their promising potential for the treatment of deadly diseases including cancer and cholesterol related pathologies. Understanding of the impact of miRNA-based regulation of apoptosis and metabolic processes is still at its dawn and needs further research for the development of future miRNA-based therapies. As both these physiological processes affect cellular homeostasis, we believe that this comprehensive summary of miRNAs modulating both apoptosis and cholesterol metabolism will open uncharted territory for scientific exploration and will provide the foundation for discovering novel drug targets for cancer and metabolic diseases.
Cellular and Molecular Neuroscience, National Brain Research Centre, Manesar, 122051, India. yogita@nbrc.ac.in.
Yogita K
YK
Adlakha
Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, 110007, India. nsaini@igib.in.
Neeru
N
Saini
D000818:Animals; D017209:Apoptosis; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics* / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*
D035683:MicroRNAs; D002784:Cholesterol
Apoptosis; Cancer; Cholesterol; Metabolic diseases; Metabolism; miRNAs