Retrospective analysis of bevacizumab-induced hypertension and clinical outcome in patients with colorectal cancer and lung cancer.
Bevacizumab(Avastin(®) ), a humanized therapeutic monoclonal antibody that targets vascular endothelial growth factor, is widely used in cancer treatment. Patients who are treated with bevacizumab have an increased risk of developing systemic hypertension. However, the relationship between bevacizumab-induced hypertension and clinical outcome remains unclear. We aimed to evaluate the effect of bevacizumab-induced hypertension in terms of prognosis in patients with colorectal cancer and non-small cell lung cancer. The study included 632 patients, 317 patients with non-small cell lung cancer and 315 patients with colorectal cancer. All patients were treated with bevacizumab in combination with standard chemotherapy protocols, between April 2007 and December 2014. Blood pressure was measured before each treatment cycle. In the patient group with colorectal cancer, treated with bevacizumab, Grade 2-3 hypertension was present in 27.6%. In hypertensive patients with colorectal cancer, median overall survival was 42.6 months, compared with 20.6 months for normotensive patients in this group (P = 0.00071). In the patient group with non-small cell lung cancer, treated with bevacizumab, Grade 2-3 hypertension was present in 20.5%. In hypertensive patients with non-small cell lung cancer, median overall survival was 43.0 months, compared with 26.3 months for normotensive patients in this group (P = 0.00451). Patients who developed hypertension during treatment with bevacizumab for colorectal cancer and non-small cell lung cancer had significantly prolonged overall survival when compared with normotensive patients. Bevacizumab-induced hypertension may represent a biomarker for clinical benefit in cancer patients treated with bevacizumab.
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Aya
A
Nakaya
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Takayasu
T
Kurata
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Takashi
T
Yokoi
Department of Surgery, Kansai Medical University, Osaka, Japan.
Shigeyoshi
S
Iwamoto
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Yoshitaro
Y
Torii
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Yuichi
Y
Katashiba
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Makoto
M
Ogata
Department of Surgery, Kansai Medical University, Osaka, Japan.
Madoka
M
Hamada
Department of Surgery, Kansai Medical University, Osaka, Japan.
Masanori
M
Kon
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Shosaku
S
Nomura
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D000068258:Bevacizumab / Q000008:administration & dosage / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D063868:Patient Outcome Assessment; D011379:Prognosis; D012189:Retrospective Studies
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D000068258:Bevacizumab
Avastin®; bevacizumab; colorectal cancer; hypertension; non-small cell lung cancer