Transfusion Considerations in Pediatric Hematology and Oncology Patients.
Pediatric patients with malignancies or benign hematologic diseases are a heterogeneous group with complicated underlying pathophysiologies leading to their requirements for transfusion therapy. Common practice among pediatric hematologists, oncologists, and transplant physicians is to transfuse stable patients red cells to maintain a hemoglobin greater than 7 or 8 g/dL and transfuse platelets to maintain a count greater than 10,000 or 20,000 platelets/μL. This review compiles data from myriad studies performed in pediatric patients to give readers the knowledge needed to make an informed choice when considering different management strategies for the transfusion of red blood cells, platelets, plasma, and granulocytes.
Medical Sciences Institute, BloodCenter of Wisconsin, 638 North 18th Street, Milwaukee, WI 53233, USA; Department of Pathology and Pediatrics, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA. Electronic address: rachel.bercovitz@bcw.edu.
Rachel S
RS
Bercovitz
Department of Pathology and Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, 1405 Clifton Road Northeast, Atlanta, GA 30322, USA.
Cassandra D
CD
Josephson
D000293:Adolescent; D016913:Blood Component Transfusion / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000628:therapy*
Anemia; Granulocyte transfusion; Pediatrics; Platelet transfusion; Red blood cell transfusion; Thrombocytopenia; Transfusions