Stabilisation of an amorphous form of ROY through a predicted co-former interaction.
The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours.
Durham University, Division of Pharmacy, Queen's Campus, Stockton on Tees, TS17 6BH, UK. d.j.berry@durham.ac.uk.
Philip A
PA
Corner
Durham University, Division of Pharmacy, Queen's Campus, Stockton on Tees, TS17 6BH, UK. d.j.berry@durham.ac.uk.
J Jonathan
JJ
Harburn
Department of Chemistry, Durham University, University Science Laboratories, South Road, Durham, DH1 3LE, UK.
Jonathan W
JW
Steed
Pharmaceutical Development, AstraZeneca Macclesfield, SK10 2SN, UK.
James F
JF
McCabe
Durham University, Division of Pharmacy, Queen's Campus, Stockton on Tees, TS17 6BH, UK. d.j.berry@durham.ac.uk.
David J
DJ
Berry