[Research progress on active ingredients of traditional Chinese medicines improved insulin resistance based on PPARs targets].
Peroxisome proliferator-activated receptors (PPARs) are nuclear transcriptional factors closely related to glucose and lipid metabolism, insulin sensitivity. Activation of PPARs targets treated type 2 diabetes, obesity, hypertension and other metabolic diseases by insulin resistance. Recently, a variety of active ingredients of traditional Chinese medicines (TCMs) have been proved to activate PPARs targets for improving insulin resistance, which has attracted widespread attention at home and abroad. In this paper, we reviewed the pathological mechanisms between insulin resistance and PPARs, and summarized the active ingredients of TCMs improved insulin resistance based on PPARs targets. This paper may provide some theoretical guidance for the development of new drugs and TCMs.
Hui-jie
HJ
Jiang
Xiao-jing
XJ
Zhang
Hui
H
Zhang
Ji-zhong
JZ
Yan
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007333:Insulin Resistance; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D047492:Peroxisome Proliferator-Activated Receptors