Distribution of hepatitis C virus genotypes in volunteer blood donors from Chengdu, China.
Hepatitis C virus (HCV) is a significant pathogen of global concern. The virus is usually spread through blood contact, such as transfusion, hemodialysis and injection of illegal drugs. HCV genotypes have a geographic distribution in different areas. In this paper, we focus on the distribution of HCV genotypes from volunteer blood donors in Chengdu. The prevalence of genotypes was analyzed using phylogenetic analysis. Phylogenetic trees were constructed based on the HCV core and NS5B regions from 313 sequences. HCV sequences were classified into six subtypes, and HCV genotypes were determined with the following results: 1b in 283, 2a in 14, 3b in seven, 3a in three, 6a in five and 6u in one. Subtype 1b was the most common and accounted for approximately 90.41 % (283/313), and a virus of subtype 6u was isolated for the first time from the Chengdu area. Genotypes 4 and 5 were not detected.
Blood Research Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China. mayflower1026@126.com.
Tianxiang
T
Gong
Blood Screening Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China.
Xin
X
Zhao
College of Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Yijia
Y
Luo
Blood Research Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China.
Ying
Y
Hong
Blood Screening Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China.
Shuping
S
Li
Blood Research Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China.
Xuemei
X
Fu
D000293:Adolescent; D000328:Adult; D001769:Blood / Q000821:virology*; D001782:Blood Donors / Q000706:statistics & numerical data*; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D014759:Viral Envelope Proteins / Q000235:genetics; D055815:Young Adult
D014759:Viral Envelope Proteins