[Interaction between antihypertensive therapy and exercise training therapy requires drug regulation in hypertensive patients].
BACKGROUND
Exercise training could interact with the pharmacological therapy of hypertension, increasing the effects of these medications.


OBJECTIVE
To assess the effects of 12 weeks of physical training on blood pressure of hypertensive or diabetic patients, already receiving pharmacological therapy.


METHODS
Twelve participants with diabetes and hypertension, 16 participants with hypertension and 18 healthy participants were studied. During six weeks no intervention was carried out, except the treatment for their underlying conditions. During the ensuing six weeks, participants were subjected 12 sessions of physical training. Blood pressure was measured at baseline and after six and twelve weeks of intervention.


RESULTS
During the period without physical training, no changes in blood pressure were observed. After the physical training intervention systolic blood pressure decreased by 16, 17 and 20 mm Hg in participants with diabetes and hypertension, participants with hypertension and healthy participants, respectively. Diastolic blood pressure decreased by 9 and 6 mmHg in participants with diabetes and hypertension and hypertension alone, respectively.


CONCLUSIONS
There is a decrease in blood pressure among hypertensive participants receiving pharmacological therapy, after a period of physical training.
Johnattan
J
Cano-Montoya
Rodrigo
R
Ramírez-Campillo
Cristian
C
Martínez
Farid
F
Sade-Calles
Andrés
A
Salas-Parada
Cristian
C
Álvarez
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D003131:Combined Modality Therapy / Q000379:methods; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D007004:Hypoglycemic Agents; D008687:Metformin