Does acute exposure to aldehydes impair pulmonary function and structure?
Mixtures of anhydrous ethyl alcohol and gasoline substituted for pure gasoline as a fuel in many Brazilian vehicles. Consequently, the concentrations of volatile organic compounds (VOCs) such as ketones, other organic compounds, and particularly aldehydes increased in many Brazilian cities. The current study aims to investigate whether formaldehyde, acetaldehyde, or mixtures of both impair lung function, morphology, inflammatory and redox responses at environmentally relevant concentrations. For such purpose, C57BL/6 mice were exposed to either medical compressed air or to 4 different mixtures of formaldehyde and acetaldehyde. Eight hours later animals were anesthetized, paralyzed and lung mechanics and morphology, inflammatory cells and IL-1β, KC, TNF-α, IL-6, CCL2, MCP-1 contents, superoxide dismutase and catalalase activities were determined. The extra pulmonary respiratory tract was also analyzed. No differences could be detected between any exposed and control groups. In conclusion, no morpho-functional alterations were detected in exposed mice in relation to the control group.
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Mariana de
Md
Abreu
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil.
Alcendino Cândido
AC
Neto
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Giovanna
G
Carvalho
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil.
Natalia Vasconcelos
NV
Casquillo
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil.
Niedja
N
Carvalho
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil.
Renata
R
Okuro
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil.
Gabriel C Motta
GC
Ribeiro
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Mariana
M
Machado
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Aléxia
A
Cardozo
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Aline Santos E
AS
Silva
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil.
Thiago
T
Barboza
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil; Laboratory of Inflammation and Immunity, Imunology Institute, Paulo Góes Mycrobiology Institute, Brazil.
Luiz Ricardo
LR
Vasconcellos
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Inflammation and Immunity, Imunology Institute, Paulo Góes Mycrobiology Institute, Brazil.
Danielle Araujo
DA
Rodrigues
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Luciana
L
Camilo
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Inflammation and Immunity, Imunology Institute, Paulo Góes Mycrobiology Institute, Brazil.
Leticia de A M
Lde A
Carneiro
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Biomedics Instrumentation, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Frederico
F
Jandre
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Biomedics Instrumentation, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Alexandre V
AV
Pino
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil.
Antonio
A
Giannella-Neto
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Walter A
WA
Zin
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Leonardo Holanda Travassos
LH
Corrêa
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Biomedics Instrumentation, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marcio Nogueira de
MN
Souza
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil. Electronic address: acarvalho@biof.ufrj.br.
Alysson R
AR
Carvalho
D000079:Acetaldehyde / Q000633:toxicity*; D000393:Air Pollutants / Q000633:toxicity*; D000397:Air Pollution; D000818:Animals; D001696:Biomechanical Phenomena; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D011312:Pressure; D012123:Pulmonary Ventilation; D013997:Time Factors; D055549:Volatile Organic Compounds / Q000633:toxicity*
D000393:Air Pollutants; D055549:Volatile Organic Compounds; D005557:Formaldehyde; D000079:Acetaldehyde
Acetaldehyde; Air pollution; Formaldehyde; Inflammation; Lung mechanics; Morphology