Omics Profiling in Precision Oncology.
Cancer causes significant morbidity and mortality worldwide, and is the area most targeted in precision medicine. Recent development of high-throughput methods enables detailed omics analysis of the molecular mechanisms underpinning tumor biology. These studies have identified clinically actionable mutations, gene and protein expression patterns associated with prognosis, and provided further insights into the molecular mechanisms indicative of cancer biology and new therapeutics strategies such as immunotherapy. In this review, we summarize the techniques used for tumor omics analysis, recapitulate the key findings in cancer omics studies, and point to areas requiring further research on precision oncology.
From the ‡Department of Genetics, Stanford University School of Medicine, Stanford, California; §Biomedical Informatics Program, Stanford University School of Medicine, Stanford, California.
Kun-Hsing
KH
Yu
From the ‡Department of Genetics, Stanford University School of Medicine, Stanford, California; mpsnyder@stanford.edu.
Michael
M
Snyder
D019295:Computational Biology / Q000379:methods*; D023281:Genomics / Q000379:methods; D006801:Humans; D055432:Metabolomics / Q000379:methods; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D057285:Precision Medicine; D011379:Prognosis; D040901:Proteomics / Q000379:methods