Maternal serum 25-hydroxyvitamin D and C-reactive protein levels in pregnancies complicated with threatened preterm labour.
OBJECTIVE
To measure 25-hydroxyvitamin D [25(OH)D] and C-reactive protein (CRP) serum levels in singleton gestations complicated with threatened preterm labour (TPL, n = 59) and compare to normal controls matched for gestational age (n = 64). Cases were treated after blood sample according to institutional protocol. Also, analyte levels were compared among cases according to the outcome.


RESULTS
Mean serum 25(OH)D levels were similar between cases and controls, with median white blood cell count and CRP levels found significantly higher in TPL cases. Women with TPL delivering preterm displayed shorter mean cervical lengths along with higher CRP and lower 25(OH)D serum levels when compared to those delivering at term. Two multiple linear regression models were constructed to analyse factors related to gestational age at delivery (pooled analysis and only those with TPL). In both models, gestational age positively correlated to cervical length and inversely to CRP levels; whereas, in the TPL model, only 25(OH)D levels correlated positively.


CONCLUSIONS
Women complicated with TPL showed similar serum 25(OH)D yet higher CRP levels as compared to controls. TPL cases delivering preterm displayed lower 25(OH)D and higher CRP correlated levels.
a Department of Obstetrics and Gynecology , Hospital Torrecárdenas , Almeria , Spain.
Natalia
N
Fischer-Suárez
a Department of Obstetrics and Gynecology , Hospital Torrecárdenas , Almeria , Spain.
Ana M
AM
Fernández-Alonso
a Department of Obstetrics and Gynecology , Hospital Torrecárdenas , Almeria , Spain.
Alejandra
A
Herrera-Muñoz
b Institute of Biomedicine, Research Area for Women's Health, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil , Guayaquil , Ecuador.|c Enrique C. Sotomayor Obstetrics and Gynecology Hospital , Guayaquil , Ecuador , and.
Peter
P
Chedraui
d Department of Obstetrics and Gynecology , Facultad de Medicina, Universidad de Zaragoza, Hospital Clínico Lozano Blesa , Zaragoza , Spain.
Faustino R
FR
Pérez-López
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
D014807:Vitamin D; D002097:C-Reactive Protein; C104450:25-hydroxyvitamin D
C-reactive protein; pregnancy; preterm delivery; preterm labour, vitamin D