MicroRNA-1908 is a biomarker for poor prognosis in human osteosarcoma.
OBJECTIVE
The aim of the present study was to analyze microRNA-1908 expression in human osteosarcoma and to explore the potential of miRNAs as biomarkers for patient outcomes.


METHODS
Real-time quantitative polymerase chain reaction assay was performed to evaluate the expression level of microRNA-1908 in 212 patients diagnosed osteosarcoma. The association of miR-1908 expression with clinicopathological factors or the prognosis of glioma patients were also analyzed. Furthermore, the Kaplan-Meier method and Cox's proportional hazards model was used to determine survival rate.


RESULTS
MiR-1908 expression levels in osteosarcoma tissues were significantly higher than those in matched adjacent normal bone tissues (p < 0.001). Tumors with high miR-1908 expression had significantly greater extent of recurrence (p < 0.003), metastasis (p = 0.000), and chemotherapy response (p < 0.019) than those with low miR-1908 expression. Kaplan-Meier analysis showed that patients with low level of miR-1908 had favorable trends of survival (p < 0.001). The result of the multivariate analysis showed that miR-1908 expression level and metastasis status retained significance as an independent prognostic factor of human osteosarcoma.


CONCLUSIONS
Our study demonstrates that increased microRNA-1908 expression is associated with poor clinical outcome in human osteosarcoma.
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Lian
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Wang
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Liu
D014408:Biomarkers, Tumor / Q000235:genetics; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000235:genetics; D012516:Osteosarcoma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D012008:Recurrence; D015996:Survival Rate
D014408:Biomarkers, Tumor; C577645:MIRN1908 microRNA, human; D035683:MicroRNAs