Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises.
Effect of time delay (τ) on intracellular calcium dynamics with non-Gaussian noises in transmission processes of intracellular Ca(2+) is studied by means of second-order stochastic Runge-Kutta type algorithm. By simulating and analyzing time series, normalized autocorrelation function, and characteristic correlation time of cytosolic and calcium store's Ca(2+) concentration, the results exhibit: (i) intracellular calcium dynamics's time coherence disappears and stability strengthens as τ → 0.1s; (ii) for the case of τ < 0.1s, the normalized autocorrelation functions of cytosolic and calcium store's Ca(2+) concentration show damped motion when τ is very short, but they trend to a level line as τ → 0.1s, and for the case of τ > 0.1s, they show different variation as τ increases, the former changes from underdamped motion to a level line, but the latter changes from damped motion to underdamped motion; and (iii) at the moderate value of time delay, reverse resonance occurs both in cytosol and calcium store.
City college/State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization, Kunming University of Science and Technology, Kunming 650051, P.R. China.
Wei-Long
WL
Duan
City college/State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization, Kunming University of Science and Technology, Kunming 650051, P.R. China.|Faculty of Science, Kunming University of Science and Technology, Kunming 650093, P.R. China.
Chunhua
C
Zeng
D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D007700:Kinetics; D008962:Models, Theoretical; D013997:Time Factors
D002118:Calcium