NORADRENERGIC MECHANISMS IN THE PROCONVULSANT EFFECTS OF BUSPIRONE.
The effect of buspirone on the protection of chemically and electrically-induced seizures by anticonvulsant drugs was studied in mice. We found antagonism to the protective action of sodium valproate (300 mg/kg, po), carbamazepine (420 mg/kg, po) and phenytoin (23.2 mg/kg, po) against picrotoxin (3.5 mg/kg, ip) and maximal electroshock (54 mA, 0.2s) induced seizures by BUS (20 mg/kg, po) and a reversal of such antagonism by pretreatment with clonidine (1 mg/kg, po). The effects appear to be elicited through central α2 adrenoceptor mechanisms.
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062.
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D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002065:Buspirone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010852:Picrotoxin / Q000494:pharmacology; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced*
D000927:Anticonvulsants; D002065:Buspirone; D010852:Picrotoxin; D018341:Receptors, Adrenergic, alpha-2