Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians.
OBJECTIVE
The objective of this study was to study the association of polymorphisms MTHFR C677T (rs1801133) and MTR A2756G (rs1805087) with the risk of varicose veins in ethnical Russians.


METHODS
We genotyped 475 patients with varicose veins, 168 individual without chronic venous disease, and the population-based group of 896 subjects. Association was studied using logistic regression analysis adopting co-dominant, additive, recessive, and dominant models of inheritance.


RESULTS
None of the polymorphisms showed a statistically significant association with the risk of varicose veins.


CONCLUSIONS
Our results provide evidence that the studied polymorphisms do not contribute to genetic susceptibility to varicose veins in ethnical Russians.
a Institute of Chemical Biology and Fundamental Medicine , Novosibirsk , Russia ;|b Novosibirsk State University , Novosibirsk , Russia ;
Alexandra Sergeevna
AS
Shadrina
a Institute of Chemical Biology and Fundamental Medicine , Novosibirsk , Russia ;
Kseniya Sergeevna
KS
Sevost'ianova
a Institute of Chemical Biology and Fundamental Medicine , Novosibirsk , Russia ;
Andrey Ivanovich
AI
Shevela
c Pirogov Russian National Research Medical University , Moscow , Russia ;
Evgenii Yurievich
EY
Soldatsky
c Pirogov Russian National Research Medical University , Moscow , Russia ;
Evgenii Igorevich
EI
Seliverstov
d Private Surgery Center "Medalp" , Saint Petersburg , Russia ;
Marina Yurievna
MY
Demekhova
d Private Surgery Center "Medalp" , Saint Petersburg , Russia ;
Oleg Aleksandrovich
OA
Shonov
d Private Surgery Center "Medalp" , Saint Petersburg , Russia ;
Evgenii Arkadievich
EA
Ilyukhin
a Institute of Chemical Biology and Fundamental Medicine , Novosibirsk , Russia ;
Mariya Aleksandrovna
MA
Smetanina
a Institute of Chemical Biology and Fundamental Medicine , Novosibirsk , Russia ;|b Novosibirsk State University , Novosibirsk , Russia ;
Elena Nikolaevna
EN
Voronina
e Novosibirsk State Medical University , Novosibirsk , Russia ;
Ilya Victorovich
IV
Pikalov
c Pirogov Russian National Research Medical University , Moscow , Russia ;
Igor Anatolyevich
IA
Zolotukhin
a Institute of Chemical Biology and Fundamental Medicine , Novosibirsk , Russia ;|b Novosibirsk State University , Novosibirsk , Russia ;|f Kazan Federal University , Kazan , Republic of Tatarstan, Russia.
Maxim Leonidovich
ML
Filipenko
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D016015:Logistic Models; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012426:Russia; D014648:Varicose Veins / Q000235:genetics*
C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; C585801:MTR protein, human
Association; SNP; folate-metabolizing genes