Management of non-ovarian cancer malignant ascites through indwelling catheter drainage.
BACKGROUND
Intra-abdominal placement of the Central Venous Catheter (CVC) was conducted to manage the ascites-related symptoms of non-ovarian cancer patients. The aim of this study is to document the efficacy of symptom relief and conduct survival analysis of non-ovarian cancer patients with malignant ascites who received paracentesis and indwelling catheter drainage.


METHODS
Seventy eight patients received paracentesis and drainage. All patients who met the inclusion criteria were included in this study. The overall survival (OS) was defined as the interval between initial diagnosis and death. Since-paracentesis survival (SP-Survival) was defined as the interval between initial paracentesis and death.


RESULTS
Hepatic cancer was the most frequent original cancer in this study. Peritoneal catheters remained in situ for a median of 13 days. No immediate complications, such as perforation of a viscus or excessive bleeding, were encountered during placement. All ascites-related symptoms improved after drainage compared with the baseline. There was a statistically significant improvement in the mean score for abdominal swelling (p < 0.001), anorexia (p = 0.023) and constipation (p = 0.045). Cancer type was shown to be an independent prognostic factor for overall survival length (p = 0.001). Serum albumin was an independent prognostic factor for SP-survival (p = 0.02).


CONCLUSIONS
Paracentesis and indwelling catheter drainage through CVC set is a useful method for improving painful symptom. Further research is needed to validate the findings.
Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Xiaoli
X
Gu
Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Yuanyuan
Y
Zhang
Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Menglei
M
Cheng
Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Minghui
M
Liu
Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zhe
Z
Zhang
Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. wenwucheng@yahoo.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. wenwucheng@yahoo.com.|, #270, DongAn Road, Shanghai, 200032, People's Republic of China. wenwucheng@yahoo.com.
Wenwu
W
Cheng
D001201:Ascites / Q000451:nursing*; D002405:Catheterization, Central Venous / Q000379:methods*; D002408:Catheters, Indwelling; D019468:Disease Management; D004322:Drainage / Q000451:nursing*; D006801:Humans; D008875:Middle Aged; D059408:Pain Management / Q000379:methods; D019152:Paracentesis / Q000451:nursing*; D010529:Peritoneal Cavity / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000150:complications; D016019:Survival Analysis
Drainage; Indwelling catheter; Malignant ascites; Palliative care; Paracentesis; Symptom management