Nature's Strategy for Catalyzing Diels-Alder Reaction.
The enzymes catalyzing a Diels-Alder-type reaction have been attractive targets for organic chemists for years. Recently, Zheng et al. (2016) reported the structure of a formal monofunctional Diels-Alderase PyrI4 complexed with the product and unveiled a detailed catalytic mechanism of a highly important enzyme.
Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan. Electronic address: hoik@sci.hokudai.ac.jp.
Hideaki
H
Oikawa
D055162:Biocatalysis; D061565:Cycloaddition Reaction; D019746:Intramolecular Oxidoreductases / Q000378:metabolism*; D008148:Lovastatin / Q000378:metabolism*; D008968:Molecular Conformation; D048630:Polyketide Synthases / Q000378:metabolism*
D048630:Polyketide Synthases; D008148:Lovastatin; D019746:Intramolecular Oxidoreductases; C113265:solanapyrone synthase