Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.
Biological Research Institute, Cluj Napoca, 400113, Romania.|Department of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, 400028, Romania.|National Institute for Research and Development of Isotopic and Molecular Technologies, 400293, Cluj-Napoca, Romania.
Vlad Al
VA
Toma
Biological Research Institute, Cluj Napoca, 400113, Romania.|Department of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, 400028, Romania.|National Institute for Research and Development of Isotopic and Molecular Technologies, 400293, Cluj-Napoca, Romania.
Anca D
AD
Farcaș
Biological Research Institute, Cluj Napoca, 400113, Romania.
Ioana
I
Roman
Department of Pathophysiology, University of Agricultural Sciences and Veterinary Medicine, Cluj Napoca, 400372, Romania.
Bogdan
B
Sevastre
Department of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, 400028, Romania.|National Institute for Research and Development of Isotopic and Molecular Technologies, 400293, Cluj-Napoca, Romania.
Denisa
D
Hathazi
Department of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, 400028, Romania.
Florina
F
Scurtu
Department of Physics, Babes-Bolyai University, Cluj-Napoca, 400028, Romania.
Grigore
G
Damian
Department of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, 400028, Romania.
Radu
R
Silaghi-Dumitrescu
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001802:Blood Substitutes / Q000009:adverse effects / Q000494:pharmacology*; D002417:Cattle; D006403:Hematologic Tests; D006454:Hemoglobins / Q000009:adverse effects / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism
D001786:Blood Glucose; D001802:Blood Substitutes; D006454:Hemoglobins; D017382:Reactive Oxygen Species; D014168:Transferrin; D007501:Iron