[Role of eukaryotic translation initiation factor 4G in tumor].
Eukaryotic translation initiation factor 4G (eIF4G) is a scaffold component of eukaryotic translation initiation factor 4F (eIF4F) complex, which takes principal part in the initiating of protein synthesis. Both two subtypes (eIF4G1 and eIF4G2) of eIF4G were found to be closely related with various tumors. The eIF4G1 expression is significantly up-regulated in breast cancer, cervical cancer, nasopharyngeal carcinoma, lung squamous cell carcinoma, prostatic carcinoma and other malignant tumors, compared with those in adjacent tissues; and the eIF4G2 is obviously over-expressed in diffuse large B cell lymphoma and acute myeloid leukemia, but low-expressed in bladder transitional cell carcinoma. This paper reviews the progress in the study of the role of eIF4G in tumor genesis, development, diagnosis and prognosis.
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
Si
S
Zhang
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
Nan
N
Huang
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
Xia
X
Pan
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
Jing-Lei
JL
Zang
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
Xin-Xin
XX
Guan
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
Jian-Hua
JH
Zhang
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
Liu-Cheng
LC
Liu
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China. 1622214323@qq.com.
Xiao-Yong
XY
Lei
D039603:Eukaryotic Initiation Factor-4G; D006801:Humans; D009369:Neoplasms; D014176:Protein Biosynthesis; D015854:Up-Regulation
C113920:EIF4G1 protein, human; D039603:Eukaryotic Initiation Factor-4G