Inflammatory Markers and the Risk of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Systemic inflammatory factors are inconsistently associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). We conducted a systematic review and meta-analysis to summarize the evidence supporting the association between systemic inflammation and the risk of COPD. Pertinent studies were retrieved from PubMed, EmBase, and the Cochrane Library until April 2015. A random-effects model was used to process the data, and the analysis was further stratified by factors affecting these associations. Sensitivity analyses for publication bias were performed. We included 24 observational studies reporting data on 10,677 COPD patients and 28,660 controls. Overall, we noted that COPD was associated with elevated serum CRP (SMD: 1.21; 95%CI: 0.92-1.50; P < 0.001), leukocytes (SMD: 1.07; 95%: 0.25-1.88; P = 0.010), IL-6 (SMD: 0.90; 95%CI: 0.48-1.31; P < 0.001), IL-8 (SMD: 2.34; 95%CI: 0.69-4.00; P = 0.006), and fibrinogen levels (SMD: 0.87; 95%CI: 0.44-1.31; P < 0.001) when compared with control. However, COPD was not significantly associated with TNF-α levels when compared with control (SMD: 0.60; 95%CI: -0.46 to 1.67; P = 0.266). Our findings suggested that COPD was associated with elevated serum CRP, leukocytes, IL-6, IL-8, and fibrinogen, without any significant relationship with TNF-α.
Medical Simulation Teaching Base, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.|Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Bin
B
Su
Department of Orthopedics, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
Tiansheng
T
Liu
Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
Haojun
H
Fan
Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
Feng
F
Chen
Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
Hui
H
Ding
Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
Zhouwei
Z
Wu
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Hongwu
H
Wang
Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
Shike
S
Hou
D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D007249:Inflammation / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood*; D012307:Risk Factors
D015415:Biomarkers