Traumatic brain injury: a review of characteristics, molecular basis and management.
Traumatic brain injury (TBI) is a critical cause of hospitalization, disability, and death worldwide. The global increase in the incidence of TBI poses a significant socioeconomic burden. Guidelines for the management of acute TBI mostly pertain to emergency treatment. Comprehensive gene expression analysis is currently available for several animal models of TBI, along with enhanced understanding of the molecular mechanisms activated during injury and subsequent recovery. The current review focuses on the characteristics, molecular basis and management of TBI.
Ke
K
Wang
Daming
D
Cui
Neurosurgical Department, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China, lianggaoh@sina.com.
Liang
L
Gao
D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D018846:Excitatory Amino Acids / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008959:Models, Neurological; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D018846:Excitatory Amino Acids; D005609:Free Radicals; D016194:Receptors, N-Methyl-D-Aspartate