Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling.
Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Daniel R
DR
Bayzigitov
Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
Sergey P
SP
Medvedev
Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Elena V
EV
Dementyeva
State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Sevda A
SA
Bayramova
State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Evgeny A
EA
Pokushalov
State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Alexander M
AM
Karaskov
Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
Suren M
SM
Zakian