Nifedipine Induced Gingival Hyperplasia in Pregnancy: A Case Report.
BACKGROUND
It is known that calcium channel blockers are associated with a risk of gingival hyperplasia. These drugs are widely used in the management of gestational hypertensive disorders.


METHODS
A 27-year-old G1 woman presented with gingival hyperplasia at 27 weeks gestation during a hospitalisation for preeclampsia. She had been on nifedipine for hypertension for the last 9 weeks. Nifedipine was discontinued and replaced by methyldopa and already after 48 hours the gingival hyperplasia improved. She delivered two weeks later and the gingival hyperplasia resolved completely without surgical intervention. The Naranjo's score was used to prove the nifedipine's imputability.


CONCLUSIONS
This first case report of gingival hyperplasia induced by nifedipine in pregnancy could be used as a reference for clinicians in the management of this adverse effect during the pregnancy.
CHU Sainte-Justine, 3175 Chemin de la Cote-Sainte-Catherine, Montreal (Quebec) H3T 1C5. Canada.
M S
MS
Brochet
M
M
Harry
F
F
Morin
D000959:Antihypertensive Agents / Q000009:adverse effects*; D002121:Calcium Channel Blockers / Q000009:adverse effects; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D009543:Nifedipine / Q000009:adverse effects*; D011247:Pregnancy
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D009543:Nifedipine
Calcium channel blockers; dental management; gingival hyperplasia; nifedipine; preeclampsia; pregnancy