Primary extragastrointestinal stromal tumor arising in the vaginal wall: Significant clinicopathological characteristics of a rare aggressive soft tissue neoplasm.
Gastrointestinal (GI) stromal tumor is the most common mesenchymal neoplasm of the GI tract but also occurs with a lower frequency in extragastrointestinal regions and is called extragastrointestinal stromal tumor (EGIST). We report an unusual case of EGIST presenting as a vaginal mass. A 41-year-old woman presented with a gradually enlarging vaginal mass for the last 2 years. Physical examination revealed an elliptical, non-tender mass about 7.5 cm × 7 cm in size in the posterior vaginal wall and was resected completely. Under histological examination, the tumor showed a spindle cell type with coagulation necrosis, hemorrhage and high mitotic count. Immunohistochemical analysis revealed tumor cells were positive for DOG1, CD117, CD34 and p53 protein. Ki-67 labeling was 8%. Genetic analysis showed a deletion of exon 11 of the c-kit gene at codons 557-558. EGISTs should be kept in mind in the differential diagnosis in patients presenting with solid mass of the vaginal wall.
Qiu-Yu Liu, Yun-Zhen Kan, Meng-Yang Zhang, Ting-Yi Sun, Ling-Fei Kong, Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
Qiu-Yu
QY
Liu
Qiu-Yu Liu, Yun-Zhen Kan, Meng-Yang Zhang, Ting-Yi Sun, Ling-Fei Kong, Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
Yun-Zhen
YZ
Kan
Qiu-Yu Liu, Yun-Zhen Kan, Meng-Yang Zhang, Ting-Yi Sun, Ling-Fei Kong, Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
Meng-Yang
MY
Zhang
Qiu-Yu Liu, Yun-Zhen Kan, Meng-Yang Zhang, Ting-Yi Sun, Ling-Fei Kong, Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
Ting-Yi
TY
Sun
Qiu-Yu Liu, Yun-Zhen Kan, Meng-Yang Zhang, Ting-Yi Sun, Ling-Fei Kong, Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
Ling-Fei
LF
Kong
Extragastrointestinal stromal tumors; Mutation; Platelet derived growth factor receptor alpha; Vagina; c-kit