Iliac artery myointimal hyperplasia in rabbits submitted to angioplasty and treated with Moringa oleifera.
OBJECTIVE
to assess post-angioplasty myointimal hyperplasia in iliac artery of rabbits treated with extract of Moringa oleifera leaves.


METHODS
we conducted a randomized trial in laboratory animals for five weeks of follow-up, developed in the Vivarium of Pharmaceutical Technology Laboratory of the Universidade Federal da Paraíba. We used rabbits from the New Zealand breed, subjected to a hypercholesterolemic diet and angioplasty of the external iliac artery, randomized into two groups: M200 Group (n=10) - rabbits treated with 200mg/kg/day of Moringa oleifera leaves extract orally; SF group (n=10) - rabbits treated with 0.9% saline orally. After five weeks, the animals were euthanized and the iliac arteries prepared for histology. Histological sections were analyzed by digital morphometry. Statistical analysis was performed using the Student's t test. The significance level was 0.05.


RESULTS
there was no significant difference in myointimal hyperplasia between M200 and SF groups when comparing the iliac arteries submitted to angioplasty.


CONCLUSIONS
there was no difference of myointimal hyperplasia between groups treated with saline and Moringa oleifera after angioplasty.
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Jânio Cipriano
JC
Rolim
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Manoel Ricardo Sena
MR
Nogueira
Universidade Federal de Alagoas, Maceió, AL, Brasil.
Paulo Roberto da Silva
PR
Lima
Universidade Federal de Alagoas, Maceió, AL, Brasil.
Francisco Chavier Vieira
FC
Bandeira
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Mizael Armando Abrantes
MA
Pordeus
Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brasil.
Aldemar Araújo
AA
Castro
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Guilherme Benjamin
GB
Pitta
Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
Margareth de Fátima Formiga Melo
Mde F
Diniz
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Adamastor Humberto
AH
Pereira
D017130:Angioplasty / Q000009:adverse effects*; D000818:Animals; D005260:Female; D006965:Hyperplasia / Q000209:etiology / Q000517:prevention & control; D007083:Iliac Artery / Q000473:pathology*; D029588:Moringa oleifera; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control*; D011817:Rabbits; D011897:Random Allocation; D017539:Tunica Intima / Q000473:pathology*
D010936:Plant Extracts