Is insulin-like growth factor 1 (IGF-1) system an attractive target inflammatory bowel diseases? Benefits and limitation of potential therapy.
Inflammatory bowel diseases (IBD) are chronic gastrointestinal disorders with unknown etiology, whose incidence dramatically increased over the past 50 years. Currently available strategies for IBD treatment, such as biological therapies, corticosteroids, and immunosuppressive agents are effective, but their side effects and economic costs cannot be ignored. Better understanding of IBD etiology and new therapeutics are thus needed. The aim of this paper is to briefly discuss IGF-1 dependent functions, with particular focus on IGF-1 use in IBD therapy. Data collection was based on records found in medical literature. Data analysis included records published between 1984 and 2014. The IGF-1 system is involved in major physiological functions, such as cell proliferation and metabolism, and growth promotion. Most importantly IGF-1 has anti-inflammatory properties and its use in IBD treatment can be recommended. However, potential IGF-1 therapy has some limitations, which include aggravation of fibrosis in Crohn's patients and facilitated transformation to malignancy. Taken into consideration their possible side effects, IGF-1 analogs and recombinants are nonetheless a promising target for IBD therapy for a specific group of patients. Further studies, at the clinical level are thus recommended.
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Łódź, Poland.
Hubert
H
Zatorski
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Łódź, Poland.
Mateusz
M
Marynowski
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Łódź, Poland. Electronic address: jakub.fichna@umed.lodz.pl.
Jakub
J
Fichna
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D007334:Insulin-Like Growth Factor I / Q000031:analogs & derivatives / Q000502:physiology / Q000627:therapeutic use; D008954:Models, Biological; D058990:Molecular Targeted Therapy
D000893:Anti-Inflammatory Agents; D007334:Insulin-Like Growth Factor I
Inflammatory bowel diseases; Insulin-like growth factor 1; Therapy perspective