[Vitamin D and osteoimmunology].
Vitamin D was considered to be one of nutrients which has an important role in the maintenance of calcium and phosphate metabolism. It was then revealed that 1,25-dihydroxyvitamin D metabolized from vitamin D works as a calciotropic hormone. Vitamin D metabolites were further shown to affect cell proliferation and differentiation. In immune system, vitamin D metabolites modulate both innate and adaptive immunity. Epidemiological studies indicated the associations between vitamin D deficiency and various diseases such as autoimmune diseases, allergy, infection and malignancy. In addition, vitamin D supplementation was shown to improve some these diseases.
Fujii Memorial Institute of Medical Sciences, Tokushima University, Japan.
Yuichi
Y
Takashi
Fujii Memorial Institute of Medical Sciences, Tokushima University, Japan.
Seiji
S
Fukumoto
Fujii Memorial Institute of Medical Sciences, Tokushima University, Japan.
Toshio
T
Matsumoto
D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D001847:Bone Diseases / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D014807:Vitamin D / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000188:drug therapy*
D014807:Vitamin D