Clinicopathological characteristics of cancer associated with Crohn's disease.
OBJECTIVE
We examined the clinicopathological characteristics and prognosis of patients with cancer associated with Crohn's disease (CD).


METHODS
The subjects of this study were patients with cancer confirmed in a resected specimen of bowel, who were treated at our institution between September, 1974 and December, 2014.


RESULTS
We analyzed 34 patients (26 men, 8 women, median age at cancer diagnosis 43.5 years, duration of illness 18 years) and found that the number of those with CD complicated with cancer began to drastically increase after 2005. The site of onset of cancer was in an anorectal lesion in 24 (70.6 %) patients. In 17 (50 %) patients, the cancer was diagnosed before surgery; in 3 patients (8.8 %), it was based on pathological findings during surgery; and in 14 patients (41.2 %), it was based on postoperative pathological findings. Mucinous carcinoma was the dominant histological type, seen in 15 patients (44.1 %), while the special type of signet-ring cell carcinoma was found in 4 patients. The cumulative overall 5 year survival rate was 46.2 %.


CONCLUSIONS
In this group of Japanese CD patients, an anorectal lesion was the most frequent site of origin of cancer. As cancer was diagnosed preoperatively in only 50 % of these patients, the overall prognosis was poor, with a cumulative 5 year survival rate of just 46.2 %.
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Hirofumi
H
Sasaki
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. ikeuci2s@hyo-med.ac.jp.
Hiroki
H
Ikeuchi
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Toshihiro
T
Bando
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Kei
K
Hirose
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Akihiro
A
Hirata
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Teruhiro
T
Chohno
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Yuki
Y
Horio
Departments of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Naohiro
N
Tomita
Departments of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Seiichi
S
Hirota
Departments of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Yoshihiro
Y
Ide
Departments of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Yasuaki
Y
Tsuchida
Departments of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Motoi
M
Uchino
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality* / Q000473:pathology; D003424:Crohn Disease / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D055815:Young Adult
Anorectal lesion; Cancer; Crohn’s disease; Prognosis