Massive Craniofacial Gorham Disease Treated Successfully by Cisplatin and 5-Fluorouracil With Ten Years of Follow-Up: A Case Report and Literature Review.
Gorham disease (GD) is a rare osteolytic condition of unknown etiology that causes spontaneous, progressive bone resorption. The maxillofacial area is one of the regions most frequently involved in this disease. GD is characterized by its aggressiveness and rarity; therefore, the treatment modalities remain controversial, and no specific treatment method has been proved effective. The present report describes a case of GD with massive craniofacial bone involvement that was treated effectively using a combination of 5-fluorouracil and cisplatin, with 10 years of follow-up.
Assistant Professor and Head, Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Sulaimani, Sulaimani, Iraq. Electronic address: dribsg@yahoo.com.
Ibrahim Saeed
IS
Gataa
Senior House Officer, Department of Maxillofacial Surgery, Sulaimani Teaching Hospital, Sulaimani, Iraq.
Noroz Hama R
NH
Nader
Senior House Officer, Department of Maxillofacial Surgery, Sulaimani Teaching Hospital, Sulaimani, Iraq.
Dastan T
DT
Abdallah
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007571:Jaw Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010015:Osteolysis, Essential / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011862:Radiography, Panoramic; D012886:Skull / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
D002945:Cisplatin; D005472:Fluorouracil