Fast 1.5 T chest MRI for the assessment of interstitial lung disease extent secondary to systemic sclerosis.
This study aims to evaluate the utility of magnetic resonance imaging (MRI) to assess interstitial lung disease (ILD) extent in patients with systemic sclerosis (SSc). Patients with SSc and varying degrees of ILD with a high-resolution computed tomography (HRCT), pulmonary function tests (PFTs), and a chest MRI containing an ultrafast SE sequence performed less than 1 year apart were included in the study. Wells global disease extent and Goh's staging algorithm were used to measure and categorize ILD both for MRI and HRCT. Correlation and diagnostic performance of MRI compared with HRCT and PFTs were calculated. Eighteen SSc patients were studied. MRI showed a good performance to detect ILD (AUC = 0.96) and was correlated with forced vital capacity (r = -0.60, p = 0.01), diffusing capacity of the lung for carbon monoxide (r = -0.79, p = 0.04), and also with HRCT (r = 0.85, p < 0.001), but MRI extent values were consistently lower than HRCT and, thus, not directly comparable. Goh's algorithm using HRCT and transformed to be used with MRI showed a good agreement (kappa = 0.73, p < 0.001) and MRI-measured ILD extent presented good intra-observer (ICC = 0.86) and inter-observer (ICC = 0.90) reliability. In SSc patients, MRI proved to be a good technique to detect and categorize ILD extent compared with HRCT, suggesting that it may be a valuable x-ray sparing technique for selected cases.
Autoimmune Systemic Diseases Unit Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain. iagopf@yahoo.es.|Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Expression, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Room 1141, Building 50, MSC 8024, Bethesda, MD, 20892, USA. iagopf@yahoo.es.
Iago
I
Pinal-Fernandez
Department of Radiology, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain.|National Institute of Arthritis and Musculoskeletal and Skin Diseases, Barcelona, Spain.
Victor
V
Pineda-Sanchez
Department of Radiology, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain.|National Institute of Arthritis and Musculoskeletal and Skin Diseases, Barcelona, Spain.
Esther
E
Pallisa-Nuñez
Autoimmune Systemic Diseases Unit Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain.
Carmen Pilar
CP
Simeon-Aznar
Autoimmune Systemic Diseases Unit Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain.
Albert
A
Selva-O'Callaghan
Autoimmune Systemic Diseases Unit Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain.
Vicente
V
Fonollosa-Pla
Autoimmune Systemic Diseases Unit Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain.
Miquel
M
Vilardell-Tarres
D000328:Adult; D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000209:etiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012595:Scleroderma, Systemic / Q000150:complications / Q000000981:diagnostic imaging*; D013909:Thorax / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
Computed x-ray tomography; Interstitial lung diseases; Magnetic resonance imaging; Pulmonary function test; Systemic sclerosis