Assessment of the Absorbed Dose in the Kidney of Nuclear Nephrology Paediatric Patients using ICRP Biokinetic Data and Monte Carlo Simulations with Mass-Scaled Paediatric Voxel Phantoms.
The aim of this work is to use Monte Carlo simulations and VOXEL phantoms to estimate the absorbed dose in paediatric patients (aged from 2 weeks to 16 y), with normal renal function, to whom technetium-99m-dimercaptosuccinic acid (99mTc-DMSA) was administered, for diagnostic renal scintigraphy purposes; and compare them with values obtained using the International Commission on Radiological Protection (ICRP) methodology. In the ICRP methodology, the cumulated absorbed dose in the kidneys is estimated by multiplying the administered activity with the corresponding given dose coefficients. The other methods were based on Monte Carlo simulations performed on two paediatric voxel phantoms (CHILD and BABY), and another three phantoms, which were modified to suit the mass of the patients' kidneys, and other anatomical factors. Different S-values were estimated using this methodology, which together with solving the ICRP biokinetic model to determine the cumulated activities, allowed for the estimation of absorbed doses different from those obtained with the ICRP method, together with new dose coefficients. The obtained values were then compared. The deviations suggest that the S-values are strongly dependent on the patient's total body weight, which could be in contrast with the ICRP data, which is provided by age, regardless of other anatomical parameters.
Grupo de Protecção e Segurança Radiológica, Centro de Ciências e Tecnologias Nucleares (C2TN), CTN/IST, Pólo de Loures. Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS, Portugal.
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Grupo de Protecção e Segurança Radiológica, Centro de Ciências e Tecnologias Nucleares (C2TN), CTN/IST, Pólo de Loures. Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS, Portugal.
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Mendes
Helmholtz Zentrum München - German Research Center for Environmental Health (HMGU), Department of Radiation Sciences, Research Unit Medical Radiation Physics and Diagnostics, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.
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Zankl
Grupo de Protecção e Segurança Radiológica, Centro de Ciências e Tecnologias Nucleares (C2TN), CTN/IST, Pólo de Loures. Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS, Portugal.
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de Sousa
Serviço de Medicina Nuclear, Hospital Garcia de Orta, E.P.E. Av. Torrado da Silva, 2801-951 Almada, Portugal.
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Santos
Grupo de Protecção e Segurança Radiológica, Centro de Ciências e Tecnologias Nucleares (C2TN), CTN/IST, Pólo de Loures. Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS, Portugal.
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D002648:Child; D003198:Computer Simulation; D006801:Humans; D009010:Monte Carlo Method; D009398:Nephrology; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D011874:Radiometry