New Bio-Based Cu(II) Complexes and Study of their Anti-Cancer Activities.
Two new Cu(II) complexes with Picolinic acid and Tryptophan [Cu(II)(DPTR)(H2O)2](1:1) (1) and [Cu(II)(DPTR)(Phen)] (1:1:1) (2) were synthesized, characterized and studied their DNA binding, cleavage, docking and anti-cancer properties. The molecular modeling studies were carried out with energy minimized structures of metal complexes. CT-DNA binding studies revealed that the complexes bind through an intercalative mode and show good binding propensity. The docking study also confirms the intercalative mode of binding. The hydrolytic DNA cleavage activity of these complexes has been studied using gel electrophoresis. Complex 2 shows better efficiency than 1. Cell viability experiments indicated that the ligand, complexes show significant dose dependent cytotoxicity in selected cell lines. Graphical Abstract Two new Cu(II) complexes with Picolinic acid and Tryptophan, [Cu(II)(DPTR)(H2O)2](1:1) (1) and [Cu(II)(DPTR)(Phen)] (1:1:1) (2) were synthesized, characterized and studied their DNA binding, cleavage, docking and anti-cancer properties.
Department of Chemistry, Osmania University, Telangana, Hyderabad, 500 007, India. profprreddy@gmail.com.
Rabindra Reddy
RR
Pulimamidi
Department of Chemistry, Osmania University, Telangana, Hyderabad, 500 007, India.
Chandrashekar
C
Ravula
Department of Chemistry, Osmania University, Telangana, Hyderabad, 500 007, India.
Satyanarayana
S
Battu
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D062105:Molecular Docking Simulation; D009690:Nucleic Acid Conformation
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D003300:Copper; D004247:DNA
Cleavage; Cu(II) complexes; DNA binding; Docking and anti cancer activity