FET proteins regulate lifespan and neuronal integrity.
The FET protein family includes FUS, EWS and TAF15 proteins, all of which have been linked to amyotrophic lateral sclerosis, a fatal neurodegenerative disease affecting motor neurons. Here, we show that a reduction of FET proteins in the nematode Caenorhabditis elegans causes synaptic dysfunction accompanied by impaired motor phenotypes. FET proteins are also involved in the regulation of lifespan and stress resistance, acting partially through the insulin/IGF-signalling pathway. We propose that FET proteins are involved in the maintenance of lifespan, cellular stress resistance and neuronal integrity.
CHUM Research Center, Montreal, H2X 3H8, Canada.|Pathology and Cell biology department, University of Montreal, Montreal, H3T 1J4, Canada.
Martine
M
Therrien
Neurology and Neurosurgery department, McGill University, Montreal, H3A 0G4, Canada.|Montreal Neurological Hospital, Montreal, H3A 2B4, Canada.
Guy A
GA
Rouleau
Neurology and Neurosurgery department, McGill University, Montreal, H3A 0G4, Canada.|Montreal Neurological Hospital, Montreal, H3A 2B4, Canada.
Patrick A
PA
Dion
CHUM Research Center, Montreal, H2X 3H8, Canada.|Department of Neuroscience, University of Montreal, Montreal, H3T 1J4, Canada.
J Alex
JA
Parker
D000818:Animals; D016589:Astemizole; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D008136:Longevity; D009154:Mutation; D009474:Neurons / Q000378:metabolism*; D015398:Signal Transduction; D013002:Somatomedins / Q000378:metabolism; D013312:Stress, Physiological
D029742:Caenorhabditis elegans Proteins; D007328:Insulin; D013002:Somatomedins; D016589:Astemizole