Network-Level Structure-Function Relationships in Human Neocortex.
The dynamics of spontaneous fluctuations in neural activity are shaped by underlying patterns of anatomical connectivity. While numerous studies have demonstrated edge-wise correspondence between structural and functional connections, much less is known about how large-scale coherent functional network patterns emerge from the topology of structural networks. In the present study, we deploy a multivariate statistical technique, partial least squares, to investigate the association between spatially extended structural networks and functional networks. We find multiple statistically robust patterns, reflecting reliable combinations of structural and functional subnetworks that are optimally associated with one another. Importantly, these patterns generally do not show a one-to-one correspondence between structural and functional edges, but are instead distributed and heterogeneous, with many functional relationships arising from nonoverlapping sets of anatomical connections. We also find that structural connections between high-degree hubs are disproportionately represented, suggesting that these connections are particularly important in establishing coherent functional networks. Altogether, these results demonstrate that the network organization of the cerebral cortex supports the emergence of diverse functional network configurations that often diverge from the underlying anatomical substrate.
McConnel Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montréal, QC, H3A 2B4, Canada Department of Psychological and Brain Sciences.
Bratislav
B
Mišić
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Richard F
RF
Betzel
Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, 3508 GA, The Netherlands.
Marcel A
MA
de Reus
Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, 3508 GA, The Netherlands.
Martijn P
MP
van den Heuvel
Department of Psychology, University of Chicago, Chicago, IL, 60637, USA.
Marc G
MG
Berman
Rotman Research Institute, Baycrest Centre, Toronto, ON, M6A 2E1, Canada.
Anthony R
AR
McIntosh
Department of Psychological and Brain Sciences Indiana University Network Science Institute, Indiana University, Bloomington, IN, 47405, USA.
Olaf
O
Sporns
D063132:Connectome / Q000379:methods; D006801:Humans; D016018:Least-Squares Analysis; D008279:Magnetic Resonance Imaging; D015999:Multivariate Analysis; D019579:Neocortex / Q000000981:diagnostic imaging* / Q000502:physiology*; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology; D012146:Rest
connectome; multivariate; network; partial least squares