Management of Thrombotic Microangiopathic Hemolytic Anemias with Therapeutic Plasma Exchange: When It Works and When It Does Not.
Thrombotic microangiopathies are a heterogeneous group of inherited and acquired disorders sharing a common clinical presentation of microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. These disorders have been treated with plasma exchange (TPE) based on randomized controlled trials, which found this therapy to be effective in thrombotic thrombocytopenic purpura (TTP). For the remaining disorders, low- to very low-quality evidence exists for the use of TPE. When TPE is applied, the treatment regimen used for TTP is usually applied. There is a need for further evaluation of the role of TPE in the treatment of thrombotic microangiopathies other than TTP.
Division of Hospital Internal Medicine, Department of Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Tahir
T
Mehmood
Transfuse Solutions, Inc, 413 9th Avenue Northwest, Byron, MN 55920, USA.
Michelle
M
Taylor
Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: winters.jeffrey@mayo.edu.
Jeffrey L
JL
Winters
D000743:Anemia, Hemolytic / Q000150:complications / Q000628:therapy*; D006801:Humans; D010951:Plasma Exchange / Q000009:adverse effects / Q000379:methods*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic
Apheresis; Hemolytic uremic syndrome; Plasma exchange; Plasmapheresis; Thrombotic microangiopathy; Thrombotic thrombocytopenic purpura