Modulating antibiotic activity towards respiratory bacterial pathogens by co-medications: a multi-target approach.
Non-antibiotic drugs can modulate bacterial physiology and/or antibiotic activity, opening perspectives for innovative therapeutic strategies. Focusing on respiratory pathogens and considering in vitro, in vivo, and clinical data, here we examine the effect of these drugs on the expression of resistance mechanisms, biofilm formation, and intracellular survival, as well as their influence on the activity of antibiotics on bacteria. Beyond the description of the effects observed, we also comment on concentrations that are active and discuss the mechanisms of drug-drug or drug-target interactions. This discussion should be helpful in defining useful targets for adjuvant therapy and establishing the corresponding pharmacophores for further drug fine-tuning.
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Nathalie M
NM
Vandevelde
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Paul M
PM
Tulkens
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address: francoise.vanbambeke@uclouvain.be.
Françoise
F
Van Bambeke
D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D006801:Humans; D012141:Respiratory Tract Infections / Q000188:drug therapy*
D000277:Adjuvants, Pharmaceutic; D000900:Anti-Bacterial Agents