Brief Report: Seroprevalence of Pertussis Infection in HIV-Infected Adults in the United States.
Pertussis is a resurgent infection that can cause significant morbidity among adults. CD4 T cells are necessary for its clearance, but pertussis studies in HIV-infected adults are limited to case reports. We analyzed stored serum samples from 299 HIV-infected adults to determine the seroprevalence of pertussis among this population. We found that 4.3% of subjects had serologic evidence of recent pertussis infection, and annual incidence of pertussis infection among subjects not vaccinated against pertussis in the last 5 years was 10.5%-17.5%. Prospective studies are needed to define the clinical presentation of pertussis in HIV-infected adults and to optimize vaccination strategies.
*Division of Infectious Diseases, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA; †Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA; and ‡Center for Health Analytics and Discovery, Eastern Virginia Medical School, Norfolk, VA.
Stephanie B
SB
Troy
Alexandria E-B
AE
Rossheim
DaShaunda D
DD
Hilliard
Tina D
TD
Cunningham
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D015995:Prevalence; D016036:Seroepidemiologic Studies; D014481:United States / Q000453:epidemiology; D014917:Whooping Cough / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology
D000907:Antibodies, Bacterial