Electronic Biosensing with Functionalized rGO FETs.
In the following we give a short summary of examples for biosensor concepts in areas in which reduced graphene oxide-based electronic devices can be developed into new classes of biosensors, which are highly sensitive, label-free, disposable and cheap, with electronic signals that are easy to analyze and interpret, suitable for multiplexed operation and for remote control, compatible with NFC technology, etc., and in many cases a clear and promising alternative to optical sensors. The presented areas concern sensing challenges in medical diagnostics with an example for detecting general antibody-antigen interactions, for the monitoring of toxins and pathogens in food and feed stuff, exemplified by the detection of aflatoxins, and the area of smell sensors, which are certainly the most exciting development as there are very few existing examples in which the typically small and hydrophobic odorant molecules can be detected by other means. The example given here concerns the recording of a honey flavor (and a cancer marker for neuroblastoma), homovanillic acid, by the odorant binding protein OBP 14 from the honey bee, immobilized on the reduced graphene oxide gate of an FET sensor.
Center for Electrochemical Surface Technology (CEST), Wiener Neustadt 2700, Austria. rozman.ciril.fl@ait.ac.at.|AIT Austrian Institute of Technology, Wien 1220, Austria. rozman.ciril.fl@ait.ac.at.
Ciril
C
Reiner-Rozman
Center for Electrochemical Surface Technology (CEST), Wiener Neustadt 2700, Austria. caroline.kotlowski@boku.ac.at.|AIT Austrian Institute of Technology, Wien 1220, Austria. caroline.kotlowski@boku.ac.at.
Caroline
C
Kotlowski
Center for Electrochemical Surface Technology (CEST), Wiener Neustadt 2700, Austria. wolfgang.knoll@ait.ac.at.|AIT Austrian Institute of Technology, Wien 1220, Austria. wolfgang.knoll@ait.ac.at.
Wolfgang
W
Knoll
D000906:Antibodies; D000941:Antigens; D015374:Biosensing Techniques; D004581:Electronics; D059022:Food Safety; D006108:Graphite / Q000737:chemistry*; D009812:Odorants; D010087:Oxides / Q000737:chemistry*; D011485:Protein Binding; D012680:Sensitivity and Specificity; D014118:Toxins, Biological; D014173:Transistors, Electronic
D000906:Antibodies; D000941:Antigens; D010087:Oxides; D014118:Toxins, Biological; D006108:Graphite
FET; aflatoxins; antigen-antibody interaction; biosensing; food toxins; liquid-gate; odorant-binding proteins; olfaction; receptor immobilization; reduced graphene oxide (rGO graphene); smell sensor