Antinociceptive and Anti-inflammatory Activities of the Lectin from Marine Red Alga Solieria filiformis.
Lectins are proteins that bind to specific mono- or oligosaccharides. This study aimed to evaluate the antinociceptive and anti-inflammatory effects of the lectin from the red marine alga Solieria filiformis. The animals (n = 6) were pretreated with S. filiformis lectin 30 min before they were given the nociceptive or inflammatory stimulus. The antinociceptive activity was evaluated in Swiss mice using the abdominal writhing, formalin, and hot plate tests. The anti-inflammatory properties were evaluated in Wistar rats using carrageenan-induced peritonitis and paw edema induced by different phlogistic agents. The S. filiformis lectin toxicity was assayed through its application in mice (7 days). S. filiformis lectin significantly reduced the number of abdominal writhings and reduced the paw licking time in the second phase of the formalin test (p < 0.05), but it did not prolong the reaction time in the hot plate test (p > 0.05). Furthermore, S. filiformis lectin reduced neutrophil migration in a peritonitis model and reduced paw edema induced by carrageenan, dextran, and serotonin (p < 0.05). Additionally, the administration of S. filiformis lectin resulted in no signs of systemic damage. Thus, S. filiformis lectin appears to have important antinociceptive and anti-inflammatory activities and could represent a potential therapeutic agent for future studies.
Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Ticiana Monteiro
TM
Abreu
Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Natássia Albuquerque
NA
Ribeiro
Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil.
Hellíada Vasconcelos
HV
Chaves
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Roberta Jeane Bezerra
RJ
Jorge
Faculty of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Mirna Marques
MM
Bezerra
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Helena Serra Azul
HS
Monteiro
Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Ilka Maria
IM
Vasconcelos
Department of Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Érika Freitas
ÉF
Mota
Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Norma Maria Barros
NM
Benevides
D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D037102:Lectins / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010940:Plant Proteins / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000461:Rhodophyta / Q000737:chemistry*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D037102:Lectins; D010940:Plant Proteins