Physical exercise during muscle regeneration improves recovery of the slow/oxidative phenotype.
As skeletal muscle mass recovery after extensive injury is improved by contractile activity, we explored whether concomitant exercise accelerates recovery of the contractile and metabolic phenotypes after muscle injury.



After notexin-induced degeneration of a soleus muscle, Wistar rats were assigned to active (running exercise) or sedentary groups. Myosin heavy chains (MHC), metabolic enzymes, and calcineurin were studied during muscle regeneration at different time points.



The mature MHC profile recovered earlier in active rats (21 days after injury) than in sedentary rats (42 days). Calcineurin was higher in the active degenerated than in the sedentary degenerated muscles at day 14. Citrate synthase and total lactate dehydrogenase (LDH) activity decreased after injury and were similarly recovered in both active and sedentary groups at 14 or 42 days, respectively. H-LDH isozyme activity recovered earlier in the active rats.



Exercise improved recovery of the slow/oxidative phenotype after soleus muscle injury. Muscle Nerve 55: 91-100, 2017.
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France.|Ecole du Val-de-Grâce, Paris, France.
Nathalie
N
Koulmann
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France.
Hélène
H
Richard-Bulteau
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France.
Brigitte
B
Crassous
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France.
Bernard
B
Serrurier
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France.
Marielle
M
Pasdeloup
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France.|Ecole du Val-de-Grâce, Paris, France.
Xavier
X
Bigard
Ecole du Val-de-Grâce, Paris, France.|Institut de Recherche Biomédicale des Armées, Département Soutien Médico-Chirurgical des Forces, 1 rue du lieutenant Raoul Batany, 92140, Clamart, France.|INSERM U1197, Clamart, France.
Sébastien
S
Banzet
D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004195:Disease Models, Animal; D004546:Elapid Venoms / Q000633:toxicity; D005080:Exercise Test; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000080864:Lactate Dehydrogenase 5; D018657:Muscle Fibers, Slow-Twitch / Q000502:physiology*; D009135:Muscular Diseases / Q000139:chemically induced / Q000503:physiopathology* / Q000534:rehabilitation*; D018995:Myosin Heavy Chains / Q000235:genetics / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000379:methods*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004546:Elapid Venoms; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C501429:Ppargc1a protein, rat; C548050:RCAN1 protein, rat; D012333:RNA, Messenger; D014157:Transcription Factors; C005082:notexin; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5; C409667:lactate dehydrogenase 1; D002950:Citrate (si)-Synthase; D019703:Calcineurin; D018995:Myosin Heavy Chains
contraction; exercise; muscle phenotype; muscle-damage; regeneration