Clinical relevance of molecular diagnosis in pet allergy.
We describe the pattern of sensitisation to pet IgE components and its association with clinical symptoms. Hundred and fifty nine consecutive patients with rhinitis/asthma sensitised to dog, cat, and horse were recruited. Specific IgE to whole extracts and to pet recombinant allergens were performed. Only 5% of patients were monosensitised to animal allergens. Specific IgE to Can f 1 was significantly associated with persistent rhinitis, Can f 2 with asthma diagnosis, Can f 3 with moderate/severe rhinitis (M/S-R) and asthma diagnosis (AD), and Can f 5 with persistent and M/S-R. Positive IgE to Fel d 2 was significantly associated with M/S-R and AD, Equ c 1 with M/S-R and Equ c 3 with persistent rhinitis, AD and severe asthma. Sensitisation to ≥2 molecules or to pet albumins was associated with more severe respiratory symptoms. Molecular diagnosis in patients with pet allergy may also help clinicians to predict clinical symptoms and their severity.
Allergy department, Fundacion Jimenez Diaz, Madrid, Spain.
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Uriarte
Allergy department, Fundacion Jimenez Diaz, Madrid, Spain.|CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Universidad Autonoma de Madrid, Madrid, Spain.
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Sastre
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D000818:Animals; D002415:Cats; D002648:Child; D002675:Child, Preschool; D004285:Dogs; D005260:Female; D006736:Horses; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D057805:Pets; D012720:Severity of Illness Index; D012882:Skin Tests; D055815:Young Adult
D000485:Allergens; D007073:Immunoglobulin E
asthma; molecular diagnosis; pet allergy; rhinitis