Role of CX3CL1 in Diseases.
Chemokines are a family of small 8-10 kDa inducible cytokines. Initially characterized as chemotactic factors, they are now considered to affect not just cellular recruitment. CX3CL1 is a unique chemokine that can exist in a soluble form, as a chemotactic cytokine, or in a membrane-attached form that acts as a binding molecule. Recently, the effects of CX3CL1 on diseases, such as inflammation and cancer, have been supported and confirmed by numerous publications. However, due to its dual effects, CX3CL1 exerts numerous effects on pathophysiological conditions that have both negative and positive consequences on pathogenesis and outcome. This review article summarizes the important scientific and clinical data that now point to a critical role for CX3CL1 in diseases.
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
WangMi
W
Liu
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Libo
L
Jiang
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Chong
C
Bian
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Yun
Y
Liang
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Rong
R
Xing
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Mumingjiang
M
Yishakea
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. dong.jian@zs-hospital.sh.cn.
Jian
J
Dong
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000378:metabolism; D050197:Atherosclerosis / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism; D002448:Cell Adhesion; D054428:Chemokine CX3CL1 / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D002633:Chemotaxis; D016207:Cytokines / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism; D015658:HIV Infections / Q000150:complications / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D007962:Leukocytes / Q000166:cytology; D008268:Macular Degeneration / Q000150:complications / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D009422:Nervous System Diseases / Q000150:complications / Q000378:metabolism; D010146:Pain / Q000378:metabolism; D019707:Receptors, Chemokine / Q000378:metabolism*; D016896:Treatment Outcome
C515538:CX3CL1 protein, human; D054428:Chemokine CX3CL1; D018925:Chemokines; D016207:Cytokines; D019707:Receptors, Chemokine
CX3CL1; Chemokine; Disease