Dietary and Household Sources of Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) in the INMA Birth Cohort (Spain).
This study looked at predictors of exposure to polybrominated diphenyl ethers (PBDEs) with a focus on dietary and household-level factors. Concentrations of BDE-47, -99, -153, and -209 and their sum (∑PBDEs) were measured in cord serum. Spanish women (n = 541) completed two semiquantitative food frequency questionnaires during the first and third trimesters of pregnancy. The daily mean intake (grams) of eggs, dairy products, meat, cereals and pasta, vegetables and pulses, fruits, shellfish and cephalopods, and fish, and the weekly mean intake (servings) of lean, large oily, other oily, and other fish from both questionnaires were averaged. Information on house size, curtains and carpets at home, mattress type, housekeeping frequency, and television use was also collected later in gestation. Multivariate censored regression was used to assess the association between PBDE concentration (log2 transformed) and potential predictors. BDE-47, -99, -209 and ∑PBDE concentrations increased by 13.6%(95% CI:0.0, 29.0%), 21.1%(2.3, 43.5%), 21.7%(0.4, 47.5%) and 11.5%(2.2, 21.7%), respectively, per interquartile range increment in daily intake of shellfish and cephalopods. Fish intake was associated with BDE-99 (20.8%[1.7, 43.4%]). When fish was disaggregated by types, BDE-99 and ∑PBDEs increased by 13.8%(4.0, 24.7%) and 5.7%(0.8, 10.8%), respectively, per 1-serving/week increment in large oily fish intake. BDE-153 was associated with higher housekeeping frequency (35.9%[0.4, 83.9%]) and BDE-209 with foam mattress use (48.9%[5.8, 109.7%]). In conclusion, seafood consumption, higher housekeeping frequency, and foam mattress were associated with prenatal PBDE exposure.
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Avenida de Catalunya 21, 46020 Valencia, Spain.
Olga
O
Costa
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Avenida de Catalunya 21, 46020 Valencia, Spain.|Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
Maria-Jose
MJ
Lopez-Espinosa
Department of Preventive Medicine and Public Health, University of Oviedo , Campus del Cristo s/n, 33006 Oviedo, Asturias, Spain.|Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC) , Jordi Girona 18, 08034 Barcelona, Spain.
Esther
E
Vizcaino
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Avenida de Catalunya 21, 46020 Valencia, Spain.|Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
Mario
M
Murcia
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Avenida de Catalunya 21, 46020 Valencia, Spain.|Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
Carmen
C
Iñiguez
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.|Department of Public Health, Miguel Hernandez University , Ctra. Nacional 332, San Juan de Alicante, 03550 Alicante, Spain.
Eva M
EM
Navarrete-Muñoz
Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC) , Jordi Girona 18, 08034 Barcelona, Spain.
Joan O
JO
Grimalt
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.|Department of Preventive Medicine and Public Health, University of Oviedo , Campus del Cristo s/n, 33006 Oviedo, Asturias, Spain.
Adonina
A
Tardon
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Avenida de Catalunya 21, 46020 Valencia, Spain.|Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
Ferran
F
Ballester
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.|Department of Preventive Medicine and Public Health, University of Oviedo , Campus del Cristo s/n, 33006 Oviedo, Asturias, Spain.
Ana
A
Fernandez-Somoano
D000818:Animals; D004032:Diet; D005260:Female; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017747:Seafood; D013030:Spain
D055768:Halogenated Diphenyl Ethers