Xanthoceraside hollow gold nanoparticles, green pharmaceutics preparation for poorly water-soluble natural anti-AD medicine.
In order to increase the solubility of poorly water-soluble natural product, xanthoceraside, an effective anti-AD compound from Xanthoceras sorbifolia Bunge, and maintain its natural property, the xanthoceraside hollow gold nanoparticles were successively prepared by green ultrasonic method with silica spheres as templates and HF solution as selective etching solvent. Hollow gold nanoparticles and drug-loaded hollow gold nanoparticles were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The solubilities of xanthoceraside loaded on hollow gold nanoparticles were increased obviously from 3.0μg/ml and 2.5μg/ml to 12.7μg/ml and 10.7μg/ml at 25°C and 37°C, respectively. The results of XRD and DSC indicated that the reason for this increase was mainly due to the amorphous state of xanthoceraside loaded on the hollow gold nanoparticles. In summary, the method of loading xanthoceraside onto hollow gold nanoparticles was a green and useful strategy to improve the solubility and dissolution of poorly water-soluble natural products and worth to applying to other natural products.
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Da-Li
DL
Meng
School of Pharmacy, China Medical University, Shenyang 110122, PR China.
Lei
L
Shang
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Xiao-He
XH
Feng
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Xing-Fei
XF
Huang
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang, Liaoning 110016, PR China. Electronic address: chexin98@aliyun.com.
Xin
X
Che
D000544:Alzheimer Disease / Q000188:drug therapy*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014315:Triterpenes / Q000737:chemistry*; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction / Q000379:methods
D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012503:Saponins; D014315:Triterpenes; C548611:xanthoceraside; D014867:Water; D006046:Gold; D012822:Silicon Dioxide
Green pharmaceutics preparation; Hollow gold nanoparticles; Natural anti-AD medicine; Xanthoceraside