Renal allograft thrombosis after living donor transplantation: risk factors and obstacles to retransplantation.
Early allograft thrombosis is a devastating complication that often leads to graft loss after living donor kidney transplantation. In addition to the psychological effects on donor and recipient, it could make future kidney matches challenging due to sensitization.



The Scientific Registry of Transplant Recipients (SRTR) was queried for adult patients undergoing living donor renal transplantation from 2001 to 2010. Sensitization was defined as a panel reactive antibody of ≥50%. Early allograft thrombosis included events within 30 d of transplantation.



In multivariable logistic regression, recipient female gender (odds ratio [OR] 2.24, p < 0.001) and right kidneys (OR 1.46, p < 0.001) were associated with increased risk of thrombosis, while increasing recipient age per 10 yr (OR 0.62, p < 0.001) and recipient Asian race/ethnicity (OR 0.34, p = 0.02) were protective. In a time-varying Cox model examining factors affecting the likelihood of retransplantation, the chance of retransplantation was 37% lower (p = 0.01) once patients became sensitized. The median time to sensitization after transplantation was 288 d.



Even with relatively brief exposure to foreign antigen, sensitization occurs and delays retransplantation for recipients of living donor kidneys with early allograft thrombosis.
Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.|Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA, USA.
Joel T
0000-0001-8190-3444
JT
Adler
Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
James F
JF
Markmann
Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Heidi
H
Yeh
D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D011183:Postoperative Complications; D012042:Registries; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology*
policy; renal transplantation; retransplantation; sensitization; thrombosis