Controlled release and antibacterial activity of tetracycline hydrochloride-loaded bacterial cellulose composite membranes.
Bacterial cellulose (BC) is widely used in biomedical applications. In this study, we prepared an antibiotic drug tetracycline hydrochloride (TCH)-loaded bacterial cellulose (BC) composite membranes, and evaluated the drug release, antibacterial activity and biocompatibility. The structure and morphology of the fabricated BC-TCH composite membranes were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The TCH release results show that the incorporation of BC matrix to load TCH is able to control the release. In vitro antibacterial assay demonstrate that the developed BC-TCH composites displayed excellent antibacterial activity solely associated with the loaded TCH drug. More importantly, the BC-TCH composite membranes display good biocompatibility. These characteristics of BC-TCH composite membranes indicate that they may successfully serve as wound dressings and other medical biomaterials.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: w.shao@njfu.edu.cn.
Wei
W
Shao
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Hui
H
Liu
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Shuxia
S
Wang
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Jimin
J
Wu
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Min
M
Huang
Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing 210037, PR China.
Huihua
H
Min
State Key Laboratory of Natural Medicines, Department of Biotechnology of TCM, China Pharmaceutical University, Nanjing 210009, PR China.
Xiufeng
X
Liu
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D057809:HEK293 Cells; D006801:Humans; D008567:Membranes, Artificial; D013752:Tetracycline / Q000008:administration & dosage* / Q000737:chemistry; D014945:Wound Healing
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D002482:Cellulose; D013752:Tetracycline
Antibacterial activity; Bacterial cellulose; Biocompatibility; Controlled release; Tetracycline hydrochloride