Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography.
Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed method is a sparsity-based reconstruction with the capability to handle the non-linear nature of LDIH. We systematically characterized the algorithm through simulation and LDIH imaging studies. The method achieved the spatial resolution down to one-third of the pixel size, while requiring only single-frame imaging without any hardware modifications. This new approach can be used as a general framework to enhance the resolution in nonlinear holographic systems.
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.
Jun
J
Song
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Christine
C
Leon Swisher
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Hyungsoon
H
Im
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Sangmoo
S
Jeong
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Divya
D
Pathania
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Yoshiko
Y
Iwamoto
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Misha
M
Pivovarov
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America.
Ralph
R
Weissleder
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.|Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Hakho
H
Lee
D000465:Algorithms; D006696:Holography / Q000379:methods* / Q000592:standards; D007089:Image Enhancement / Q000379:methods