Neutrophil gelatinase-associated lipocalin in dogs with chronic kidney disease, carcinoma, lymphoma and endotoxaemia.
OBJECTIVE
To measure serum and urine neutrophil gelatinase-associated lipocalin (NGAL) concentrations in healthy dogs and dogs with chronic kidney disease, neoplasia and endotoxaemia.


METHODS
Serum and urine NGAL concentrations were measured in 42 healthy dogs, 11 dogs with chronic kidney disease, 12 dogs with carcinoma, 20 dogs with lymphoma and 15 dogs with lipopolysaccharide-induced endotoxaemia. In dogs with chronic kidney disease, NGAL was measured 3 and 6 months later.


RESULTS
Compared with healthy controls, dogs with chronic kidney disease (PÄ0·0008), carcinoma (PÄ0·0072) and lymphoma (PÄ0·0008) had elevated serum and urine NGAL and urine NGAL-to-creatinine ratio. Serum and urine NGAL was not significantly different between dogs with chronic kidney disease, carcinoma or lymphoma (Pê0·12). In dogs with non-progressive chronic kidney disease, NGAL concentrations did not change significantly over the 6-month study period.


CONCLUSIONS
NGAL can be elevated by chronic kidney disease and neoplasia, compared with healthy controls. Further research is needed to determine if uNGAL or uNGAL-to-creatinine ratio is more specific than serum levels to detect chronic kidney disease.
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
A R
AR
Cobrin
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
S L
SL
Blois
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
A C G
AC
Abrams-Ogg
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
S A
SA
Kruth
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
C
C
Dewey
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
M K
MK
Holowaychuk
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
V
V
Gauthier
D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000662:veterinary*; D003404:Creatinine / Q000378:metabolism; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D019446:Endotoxemia / Q000378:metabolism / Q000662:veterinary*; D000071068:Lipocalin-2 / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism / Q000662:veterinary*; D011446:Prospective Studies; D012016:Reference Values; D051436:Renal Insufficiency, Chronic / Q000378:metabolism / Q000662:veterinary*
D000071068:Lipocalin-2; D003404:Creatinine