Effects of Obstructive Sleep Apnea and Obesity on Cardiac Remodeling: The Wisconsin Sleep Cohort Study.
To characterize the prospective associations of obstructive sleep apnea (OSA) with future echocardiographic measures of adverse cardiac remodeling.



This was a prospective long-term observational study. Participants had overnight polysomnography followed by transthoracic echocardiography a mean (standard deviation) of 18.0 (3.7) y later. OSA was characterized by the apnea-hypopnea index (AHI, events/hour). Echocardiography was used to assess left ventricular (LV) systolic and diastolic function and mass, left atrial volume and pressure, cardiac output, systemic vascular resistance, and right ventricular (RV) systolic function, size, and hemodynamics. Multivariate regression models estimated associations between log10(AHI+1) and future echocardiographic findings. A secondary analysis looked at oxygen desaturation indices and future echocardiographic findings.



At entry, the 601 participants were mean (standard deviation) 47 (8) y old (47% female). After adjustment for age, sex, and body mass index, baseline log10(AHI+1) was associated significantly with future reduced LV ejection fraction and tricuspid annular plane systolic excursion (TAPSE) ≤ 15 mm. After further adjustment for cardiovascular risk factors, participants with higher baseline log10(AHI+1) had lower future LV ejection fraction (β = -1.35 [standard error = 0.6]/log10(AHI+1), P = 0.03) and higher odds of TAPSE ≤ 15 mm (odds ratio = 6.3/log10(AHI+1), 95% confidence interval = 1.3-30.5, P = 0.02). SaO2 desaturation indices were associated independently with LV mass, LV wall thickness, and RV area (all P < 0.03).



OSA is associated independently with decreasing LV systolic function and with reduced RV function. Echocardiographic measures of adverse cardiac remodeling are strongly associated with OSA but are confounded by obesity. Hypoxia may be a stimulus for hypertrophy in individuals with OSA.
University of Wisconsin School of Medicine and Public Health, Madison, WI.
Claudia E
CE
Korcarz
University of Wisconsin School of Medicine and Public Health, Madison, WI.
Paul E
PE
Peppard
University of Wisconsin School of Medicine and Public Health, Madison, WI.
Terry B
TB
Young
University of Wisconsin School of Medicine and Public Health, Madison, WI.
Carrie B
CB
Chapman
University of Wisconsin School of Medicine and Public Health, Madison, WI.
K Mae
KM
Hla
University of Wisconsin School of Medicine and Public Health, Madison, WI.
Jodi H
JH
Barnet
University of Wisconsin School of Medicine and Public Health, Madison, WI.
Erika
E
Hagen
University of Wisconsin School of Medicine and Public Health, Madison, WI.
James H
JH
Stein
D000328:Adult; D002318:Cardiovascular Diseases / Q000150:complications* / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D006984:Hypertrophy; D000860:Hypoxia; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009765:Obesity / Q000150:complications* / Q000503:physiopathology*; D016017:Odds Ratio; D017286:Polysomnography; D011446:Prospective Studies; D012307:Risk Factors; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology*; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling; D014922:Wisconsin
diabetes; echocardiography; hypertension; obesity; sleep apnea