Anti-Müllerian hormone and polycystic ovary syndrome.
Anti-Müllerian hormone (AMH) is expressed by the granulosa cells of the pre-antral and small antral follicles in the ovary. It is significantly higher in women with polycystic ovary syndrome (PCOS) due to an increased number of antral follicles and also a higher production per antral follicle. It is postulated to have an inhibitory role in folliculogenesis and may play an important role in the pathophysiology of anovulation associated with PCOS. Measurement of the serum AMH levels is very useful for the identification of PCOS and has been suggested as a diagnostic criterion. An international standardisation of the AMH assay, large population-based studies and a global consensus are needed before its incorporation into routine diagnosis. Serum AMH levels add significant value to the clinical markers for the prediction of hyperresponse to controlled ovarian stimulation for in vitro fertilisation treatment and development of ovarian hyperstimulation syndrome.
Homerton Fertility Centre, Homerton University Hospital, Homerton Row, London E9 6SR, UK. Electronic address: priya.bhide@homerton.nhs.uk.
Priya
P
Bhide
Homerton Fertility Centre, Homerton University Hospital, Homerton Row, London E9 6SR, UK. Electronic address: royhomburg@gmail.com.
Roy
R
Homburg
D000858:Anovulation / Q000209:etiology / Q000378:metabolism*; D054304:Anti-Mullerian Hormone / Q000378:metabolism*; D005260:Female; D006801:Humans; D006080:Ovarian Follicle / Q000378:metabolism*; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000378:metabolism; D010062:Ovulation Induction / Q000009:adverse effects; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D018570:Risk Assessment
D054304:Anti-Mullerian Hormone
Anti-Müllerian hormone; polycystic ovary syndrome