Application of autologous platelet-rich plasma to enhance wound healing after lower limb revascularization: A case series and literature review.
Dermal tissue loss in patients affected by critical limb ischemia represents a serious wound-healing problem, with high morbidity, prolonged hospital stay, and high patient care costs. Treatment of ischemic foot lesions requires limb revascularization by endovascular or open surgical intervention and individualized patient-specific wound care, including antibiotic therapy; devitalized/infected wound debridement; and advanced wound dressing. In selected patients, spinal cord stimulation, vacuum-assisted closure therapy, and bioengineered tissue or skin substitutes and growth factors have been shown to improve wound healing. In this study, we present our preliminary results on topical application of autologous platelet-rich plasma to enhance the process of wound healing after revascularization of lower limbs in patients affected by critical limb ischemia.
Unit of Vascular Surgery, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Via Melacrino n.1, 89100, Italy; Cardiovascular and Thoracic Department, Policlinico G. Martino Hospital, University of Messina, Messina, Italy. Electronic address: drmafaldamassara@gmail.com.
Mafalda
M
Massara
Unit of Vascular Surgery, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Via Melacrino n.1, 89100, Italy.
David
D
Barillà
Cardiovascular and Thoracic Department, Policlinico G. Martino Hospital, University of Messina, Messina, Italy.
Giovanni
G
De Caridi
Department of Surgical and Medical Science, University Magna Graecia of Catanzaro, Catanzaro, Italy; Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Raffaele
R
Serra
University Campus Biomedico of Rome, Rome, Italy.
Alberto
A
Volpe
Calabria Cord Blood Bank, Service of Immunohaematology and Transfusion Medicine, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy.
Rosangela
R
Surace
Calabria Cord Blood Bank, Service of Immunohaematology and Transfusion Medicine, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy.
Giovanni
G
Foti
Calabria Cord Blood Bank, Service of Immunohaematology and Transfusion Medicine, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy.
Daniela
D
Marcuccio
Calabria Cord Blood Bank, Service of Immunohaematology and Transfusion Medicine, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy.
Giulia
G
Pucci
Unit of Vascular Surgery, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Via Melacrino n.1, 89100, Italy.
Pietro
P
Volpe
D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D007871:Leg Ulcer / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D008297:Male; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D053657:Platelet-Rich Plasma; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects; D014945:Wound Healing