Identifying gene expression modules that define human cell fates.
Using a compendium of cell-state-specific gene expression data, we identified genes that uniquely define cell states, including those thought to represent various developmental stages. Our analysis sheds light on human cell fate through the identification of core genes that are altered over several developmental milestones, and across regional specification. Here we present cell-type specific gene expression data for 17 distinct cell states and demonstrate that these modules of genes can in fact define cell fate. Lastly, we introduce a web-based database to disseminate the results.
Molecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
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Germanguz
Microsoft Research, United States.
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Listgarten
Molecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
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Cinkornpumin
Molecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
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Solomon
Molecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
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Gaeta
Molecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States; Molecular Biology Institute, UCLA, United States. Electronic address: blowry@ucla.edu.
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Lowry
D000465:Algorithms; D002454:Cell Differentiation; D002478:Cells, Cultured; D065150:Cellular Reprogramming; D015870:Gene Expression; D053263:Gene Regulatory Networks / Q000235:genetics; D006801:Humans; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D014157:Transcription Factors