Repeated Intrastromal Injections of Voriconazole in Combination with Corneal Debridement for Recalcitrant Fungal Keratitis - a Case Series.
BACKGROUND
To report the use of intrastromal voriconazole injections combined with corneal debridement to treat deep recalcitrant fungal keratitis.


METHODS
Three patients (2 female and 1 male) with culture proven fungal keratitis (1 Fusarium, 1 Candida, 1 Pseudallescheria boydii) were included in this study. The patients were treated with repeated intrastromal voriconazole (100 mg/1 ml) in combination with corneal debridement.


RESULTS
The mean age of the patients was 65 years. The mean number of injections was 5. The patients were injected every 2-3 days. This technique required repeated corneal debridement to achieve complete resolution in these three cases.


CONCLUSIONS
Repeated intrastromal injection of voriconazole in combination with corneal debridement appears to be an effective and safe way to treat recalcitrant fungal keratitis, even in Fusarium keratitis.
Department of Ophthalmology, University of Lausanne, Fondation Asile des aveugles, Jules-Gonin Eye Hospital, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen).
I
I
Guber
Department of Ophthalmology, University of Lausanne, Fondation Asile des aveugles, Jules-Gonin Eye Hospital, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen).
C
C
Bergin
Department of Ophthalmology, University of Lausanne, Fondation Asile des aveugles, Jules-Gonin Eye Hospital, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen).
F
F
Majo
D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003315:Cornea / Q000601:surgery*; D003646:Debridement / Q000379:methods*; D004334:Drug Administration Schedule; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D056965:Injections, Intraocular; D007634:Keratitis / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D065819:Voriconazole / Q000008:administration & dosage*
D000935:Antifungal Agents; D065819:Voriconazole