N1 Magnitude of Auditory Evoked Potentials and Spontaneous Functional Connectivity Between Bilateral Heschl's Gyrus Are Coupled at Interindividual Level.
N1 component of auditory evoked potentials is extensively used to investigate the propagation and processing of auditory inputs. However, the substantial interindividual variability of N1 could be a possible confounding factor when comparing different individuals or groups. Therefore, identifying the neuronal mechanism and origin of the interindividual variability of N1 is crucial in basic research and clinical applications. This study is aimed to use simultaneously recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data to investigate the coupling between N1 and spontaneous functional connectivity (FC). EEG and fMRI data were simultaneously collected from a group of healthy individuals during a pure-tone listening task. Spontaneous FC was estimated from spontaneous blood oxygenation level-dependent (BOLD) signals that were isolated by regressing out task evoked BOLD signals from raw BOLD signals and then was correlated to N1 magnitude across individuals. It was observed that spontaneous FC between bilateral Heschl's gyrus was significantly and positively correlated with N1 magnitude across individuals (Spearman's R = 0.829, p < 0.001). The specificity of this observation was further confirmed by two whole-brain voxelwise analyses (voxel-mirrored homotopic connectivity analysis and seed-based connectivity analysis). These results enriched our understanding of the functional significance of the coupling between event-related brain responses and spontaneous brain connectivity, and hold the potential to increase the applicability of brain responses as a probe to the mechanism underlying pathophysiological conditions.
1 Department of Electrical and Electronic Engineering, The University of Hong Kong , Hong Kong, China .
Ao
A
Tan
2 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China .|3 Faculty of Psychology, Southwest University , Chongqing, China .
Li
L
Hu
1 Department of Electrical and Electronic Engineering, The University of Hong Kong , Hong Kong, China .
Yiheng
Y
Tu
3 Faculty of Psychology, Southwest University , Chongqing, China .
Rui
R
Chen
1 Department of Electrical and Electronic Engineering, The University of Hong Kong , Hong Kong, China .
Yeung Sam
YS
Hung
4 School of Data and Computer Science, Sun Yat-Sen University , Guangzhou, China .
Zhiguo
Z
Zhang
D000161:Acoustic Stimulation; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004569:Electroencephalography; D005071:Evoked Potentials; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D007206:Individuality; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D055815:Young Adult
Heschl's gyrus; N1; auditory evoked potentials; interindividual variability; simultaneous EEG-fMRI; spontaneous functional connectivity