Validation of cutaneous lymphoma international prognostic index (CLIPI) for mycosis fungoides and Sézary syndrome.
We sought to evaluate the performance of the cutaneous lymphoma international prognostic index (CLIPI), a prognostic index for mycosis fungoides (MF), and Sézary syndrome (SS), in our cohort of patients seen at Emory University between 1998 and 2013. Additionally, we examined the prognostic significance of lactate dehydrogenase (LDH), B0a/b, and CD30 status. A total of 390 patients were included in analysis: 78.2% early stage (IA-IIA), 7.2% with SS, 53.1% male, mean age 53.5 years. CLIPI stratified patients into low, intermediate, and high-risk groups for overall survival (OS) and progression free survival (PFS) for early stage patients (p < 0.0001), but was not significant for late stage patients. On multivariable analysis for early stage patients, age >60, plaques, folliculotropic disease was significant for OS and age >60, plaques, N1/Nx was significant for PFS. In the overall cohort, CD30+, elevated LDH, and B0b were significant for worse OS and PFS.
a Department of Radiation Oncology , Winship Cancer Institute of Emory University , Atlanta , GA , USA.
Hasan H
HH
Danish
b Center for Outcomes Research and Evaluation, Yale School of Medicine , New Haven , CT , USA.
Shuling
S
Liu
a Department of Radiation Oncology , Winship Cancer Institute of Emory University , Atlanta , GA , USA.
Jaymin
J
Jhaveri
c Department of Hematology and Medical Oncology , Winship Cancer Institute of Emory University , Atlanta , GA , USA.
Christopher R
CR
Flowers
c Department of Hematology and Medical Oncology , Winship Cancer Institute of Emory University , Atlanta , GA , USA.
Mary J
MJ
Lechowicz
a Department of Radiation Oncology , Winship Cancer Institute of Emory University , Atlanta , GA , USA.
Natia
N
Esiashvili
a Department of Radiation Oncology , Winship Cancer Institute of Emory University , Atlanta , GA , USA.
Mohammad K
MK
Khan
D000328:Adult; D000368:Aged; D015415:Biomarkers; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D017730:Ki-1 Antigen / Q000378:metabolism; D045022:Lactate Dehydrogenases / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000401:mortality*; D009367:Neoplasm Staging; D011379:Prognosis; D012751:Sezary Syndrome / Q000175:diagnosis* / Q000401:mortality*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000401:mortality*; D016019:Survival Analysis
D015415:Biomarkers; D017730:Ki-1 Antigen; D045022:Lactate Dehydrogenases
Cutaneous lymphoma international prognostic index; Sézary syndrome; mycosis fungoides