Treatment Approach to Patients With Severe Insulin Resistance.
In Brief Patients with severe insulin resistance require >2 units/kg of body weight or 200 units/day of insulin. Yet, many patients do not achieve glycemic targets despite using very high doses of insulin. Insulin can cause weight gain, which further contributes to worsening insulin resistance. This article describes the pharmacological options for managing patients with severe insulin resistance, including the use of U-500 insulin and newer agents in combination with insulin.
West Palm Beach Veteran's Administration Medical Center, West Palm Beach, FL.
Timothy J
TJ
Church
University of Maryland School of Pharmacy, Department of Pharmacy Practice and Science, Baltimore, MD.
Stuart T
ST
Haines