Chronic cerebrovascular dysfunction after traumatic brain injury.
Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long-term alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form blood vessels and that are involved in maintaining their proper function can be altered by TBI. This Review focuses on the different types of cerebrovascular dysfunction that occur after TBI, including cerebral blood flow alterations, autoregulation impairments, subarachnoid hemorrhage, vasospasms, blood-brain barrier disruption, and edema formation. We also discuss the mechanisms that mediate these dysfunctions, focusing on the cellular components of cerebral blood vessels (endothelial cells, smooth muscle cells, astrocytes, pericytes, perivascular nerves) and their known and potential roles in the secondary injury cascade. © 2016 Wiley Periodicals, Inc.
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California.
Amandine
A
Jullienne
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California.|Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California.|Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, University of California Riverside, Riverside, California.
Andre
A
Obenaus
CNRS UMR5287, University of Bordeaux, Bordeaux, France.
Aleksandra
A
Ichkova
CNRS UMR5287, University of Bordeaux, Bordeaux, France.
Catherine
C
Savona-Baron
Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California.
William J
WJ
Pearce
Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California.|CNRS UMR5287, University of Bordeaux, Bordeaux, France.
Jerome
J
Badaut
D000818:Animals; D001812:Blood-Brain Barrier / Q000503:physiopathology; D000070642:Brain Injuries, Traumatic / Q000150:complications* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000209:etiology*; D002908:Chronic Disease; D006801:Humans
cerebrovascular dysfunction; neurovascular dysfunction; traumatic brain injury