A prospective randomised controlled trial of octylcyanoacrylate tissue adhesive and standard suture for wound closure following breast surgery.
BACKGROUND
Several studies have demonstrated that octylcyanoacrylate tissue adhesive provides an equivalent cosmetic outcome as standard suture for wound closure. This study aimed to compare octylcyanoacrylate tissue adhesive with standard suture for wound closure following breast surgery.


METHODS
A prospective randomised controlled trial was conducted in a public hospital in Hong Kong. A total of 70 female patients, who underwent elective excision of clinically benign breast lump between February 2009 and November 2011, were randomised to have wound closure using either octylcyanoacrylate tissue adhesive or standard wound suture following breast surgery. Wound complications and cosmetic outcome were measured.


RESULTS
Octylcyanoacrylate tissue adhesive achieved wound closure in significantly less time than standard suturing (mean, 80.6 seconds vs 344.6 seconds; P<0.001). There was no statistical difference in wound condition or cosmetic outcome although number of clinic visits, ease of self-showering, and comfort of dressing significantly favoured octylcyanoacrylate tissue adhesive.


CONCLUSIONS
Octylcyanoacrylate tissue adhesive may be offered as an option for wound closure following breast surgery.
Department of Surgery, Queen Mary Hospital and Tung Wah Hospital, Hong Kong.
C Th
CT
Chen
Private practice, Hong Kong.
C Ly
CL
Choi
Department of Surgery, Queen Mary Hospital and Tung Wah Hospital, Hong Kong.
D Tk
DT
Suen
Department of Surgery, Queen Mary Hospital and Tung Wah Hospital, Hong Kong.
A
A
Kwong
D000328:Adult; D001943:Breast Neoplasms / Q000601:surgery*; D003487:Cyanoacrylates / Q000627:therapeutic use*; D005260:Female; D006723:Hong Kong; D006779:Hospitals, Public; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D011446:Prospective Studies; D013536:Suture Techniques; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
D003487:Cyanoacrylates; D014014:Tissue Adhesives; C119247:octylcyanoacrylate
Breast Neoplasms/surgery; Cyanoacrylates/therapeutic use; Tissue adhesives/therapeutic use; Wound healing