Guidelines for the Management of Wet Age-Related Macular Degeneration: Recommendations from a Panel of Greek Experts.
To propose guidelines for the management of patients with wet age-related macular degeneration (wAMD), taking into account the results of large multicenter studies and clinical experience of retina experts.



A team of retina experts developed a consensus paper after three consecutive meetings. The group was focused on guidelines to help clinical decision-making around the definition of successful treatment and the definition of non-response to therapy.



Parameters suggestive of a successful response to treatments included: any gain in best corrected visual acuity (BCVA) or vision loss that is less than 5-10 Early Treatment Diabetic Retinopathy Study (ETDRS) letters, reduction of central retinal thickness, partial or complete absorption of subretinal fluid (SRF), reduction of intraretinal fluid, reduction of pigment epithelial detachment or restoration of the anatomy of outer retinal layers. Non-response to current treatment was considered in the case of loss of BCVA greater than 10 ETDRS letters, increased retinal edema or increase of SRF as evidenced by optical coherence tomography or new bleeding in biomicroscopy.



The introduction of anti-VEGF agents revolutionized the treatment of wAMD. Given the complexity of the disease, the emerging new agents and the difference of cases recruited in clinical trials compared to those appearing in every-day practice, it is essential to individualize treatment options taking into account the results of clinical trials.
Department of Ophthalmology, University of Thessaly, Larissa, Greece. androudi@otenet.gr.
Sofia
S
Androudi
Department of Ophthalmology, University of Thessaly, Larissa, Greece.
Anna
A
Dastiridou
Department of Ophthalmology, University of Patras, Rion, Patras, Greece.
Nikolaos
N
Pharmakakis
Department of Ophthalmology, University of Ioannina, Epirus, Greece.
Maria
M
Stefaniotou
Department of Ophthalmology, University of Ioannina, Epirus, Greece.
Christos
C
Kalogeropoulos
2nd Department of Ophthalmology, Aristotle University, Thessaloníki, Greece.
Chrysanthos
C
Symeonidis
Athens Vision, Athens, Greece.
Alexandros
A
Charonis
Department of Ophthalmology, University of Crete, Heraklion, Greece.
Miltiadis
M
Tsilimbaris
D000368:Aged; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D019468:Disease Management; D018450:Disease Progression; D006115:Greece; D006801:Humans; D017410:Practice Guidelines as Topic; D041623:Tomography, Optical Coherence / Q000379:methods; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D057135:Wet Macular Degeneration / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A
Age-related macular degeneration; Consensus; Ophthalmology; Recommendations