Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability.
Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.
Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01326 Dresden, Germany.
Attila
A
Toth
Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01326 Dresden, Germany. Electronic address: Rolf.Jessberger@tu-dresden.de.
Rolf
R
Jessberger
D000375:Aging; D000818:Animals; D002875:Chromosomes; D006801:Humans; D008540:Meiosis; D051379:Mice; D009865:Oocytes; D009866:Oogenesis; D055550:Protein Stability