The Establishment of Adult Reference Intervals on Fructosamine in Beijing.
BACKGROUND
Fructosamine (FRA) is widely used for diabetes monitor and control as a glycemic marker, especially in patients in whom the measurement of HbA1c may be biased or even unreliable. However, the FRA reference intervals based on Asian population features still keep seldom reported. The objective of this study was to establish the adult FRA reference intervals in Beijing, China.


METHODS
A total of 1,497 healthy subjects were separated into three groups by gender and age. Subsequently, FRA levels in the collected serum samples from the reference individuals were tested by automatic chemical analyzer. The obtained data were statistically analyzed with SPSS.


RESULTS
The serum FRA level in female group was slightly higher than that in male group without statistical significance. Meanwhile, further analysis indicated that the FRA level gradually increased along with the growth of the age. Compared with the age 20-45 group (248.83 ± 17.64 μmol/l) or the age 46-65 group (251.95 ± 19.63 μmol/l), the FRA level of the age >65 group (264.63± 23.05 μmol/l) was statistically significantly increased (P < 0.01). To better analyze the difference, the age 20-45 group and the age 46-65 group were combined into an age 20-65 group (249.88 ±18.39 μmol/l). In comparison to the age >65 group, the FRA level of age 20-65 group was significantly decreased (P <0.01).


CONCLUSIONS
A novel FRA reference interval of the local healthy population in Beijing was established. The data demonstrated that there was no gender difference in FRA level, however, which was significantly increased in elder persons.
Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Xun
X
Chen
Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Jing
J
Wu
Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Ronghai
R
Li
Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Qingyong
Q
Wang
Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Yufeng
Y
Tang
Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. shangxh2056@sina.com.
Xiaohong
X
Shang
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000068476:Beijing; D005215:Fasting / Q000097:blood; D005260:Female; D019270:Fructosamine / Q000097:blood*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D055815:Young Adult
D019270:Fructosamine
diabetes; fructosamine; glycated albumin; glycated hemoglobin A1c; glycemic marker; reference interval