Viral infections associated with oral cancers and diseases in the context of HIV: a workshop report.
Human herpesviruses (HHVs) and human papillomavirus (HPV) are common in the general population and, in immunocompetent people, are mostly carried asymptomatically. However, once an individual becomes immunocompromised by age, illness or HIV infection these dormant viruses can manifest and produce disease. In HIV-positive patients, there is an increased risk of disease caused by HHVs and HPV infections and cancers caused by the oncoviruses Epstein-Barr Virus, HHV-8 and HPV. This workshop examined four questions regarding the viruses associated with oral cancers and disease in the HIV-positive and -negative populations, the immune response, and biomarkers useful for accurate diagnostics of these infections and their sequalae. Each presenter identified a number of key areas where further research is required.
Molecular Basis of Disease Research Program, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
D J
DJ
Speicher
Health Care Department, Universidad Autónoma Metropolitana-Xochimilco, México City, Mexico.
V
V
Ramirez-Amador
Department of Microbiology and Immunology School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
D P
DP
Dittmer
Department of Microbiology and Immunology School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.|Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, USA.
J
J
Webster-Cyriaque
Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
M T
MT
Goodman
David Geffen, School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
A-B
AB
Moscicki
D015415:Biomarkers; D060085:Coinfection / Q000150:complications* / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D019288:Herpesvirus 8, Human; D006801:Humans; D009059:Mouth Diseases / Q000821:virology; D009062:Mouth Neoplasms / Q000821:virology*; D009959:Oropharyngeal Neoplasms / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000821:virology*
D015415:Biomarkers
HIV infection; biomarkers; human herpesvirus; human papillomavirus; immune response; oncoviruses; oral cancer