A resected case of symptomatic acinar cell cystadenoma of the pancreas displacing the main pancreatic duct.
Acinar cell cystadenoma (ACA) of the pancreas has been newly recognized as an entity by the World Health Organization (WHO) definition (2010), and its pathogenesis has not been known adequately because of the rarity. Here, we report a case of a 22-year-old female who had been followed up for a cystic lesion at the tail of the pancreas pointed out by a screening computed tomography (CT) scan 7 years ago. The tumor grew in size from 3.3 to 5.1 cm in diameter for 6 years (0.3 cm per year). Particularly, it rapidly grew up to 6.3 cm in the latest 3 months in concurrence with the emergence of epigastralgia. A contrasted CT scan revealed the irregularly formed, multilocular cystic tumor having thin septum and calcification. The intratumoral magnetic resonance imaging intensity in the T1 and T2 weighted images were low and high, respectively. No communications between the tumor and the main pancreatic duct (MPD) were found, but the tumor displaced the MPD. She underwent surgical resection because the tumor was growing, turned symptomatic, and it seemed difficult to be diagnosed correctly until totally biopsied. Spleen-preserved distal pancreatectomy was performed. It was pathologically diagnosed as ACA; the cyst was lined by cells with normal acinar differentiation; cuboidal cells with round, basally oriented nuclei and eosinophilic granules in its apical cytoplasm. The abdominal pain has disappeared, and no recurrences have been found during a 5-year follow-up. Clinicians are recommended to consider an ACA as one of differential diagnoses of cystic tumors of the pancreas to provide appropriate diagnostics and therapeutics.
Department of Gastroenterological Surgery (Surgery II), Nagoya University, Tsurumai-cho 65, Syowa-ku, Nagoya, 466-8550, Japan. tanakaharu@med.nagoya-u.ac.jp.|Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan. tanakaharu@med.nagoya-u.ac.jp.
Haruyoshi
H
Tanaka
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Tsuyoshi
T
Hatsuno
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Mitsuru
M
Kinoshita
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Kazuya
K
Hasegawa
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Hiromasa
H
Ishihara
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Nao
N
Takano
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Satofumi
S
Shimoyama
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Hiroshi
H
Nakayama
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Masato
M
Kataoka
Department of Pathology, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Shu
S
Ichihara
Department of Gastroenterological Surgery (Surgery II), Nagoya University, Tsurumai-cho 65, Syowa-ku, Nagoya, 466-8550, Japan.
Mitsuro
M
Kanda
Department of Gastroenterological Surgery (Surgery II), Nagoya University, Tsurumai-cho 65, Syowa-ku, Nagoya, 466-8550, Japan.
Yasuhiro
Y
Kodera
Department of Surgery, Nagoya Medical Center, National Hospital Organization, sannomaru 4-1-1, naka-ku, Nagoya, 460-0001, Japan.
Ken
K
Kondo
Acinar cell cystadenoma; Cystic transformation; Pancreas; Symptomatic