Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.
SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance of SIRT6 variants on CAD is far to be elucidated. Here we aimed to investigate the influence of SIRT6 polymorphisms on individual susceptibility and severity of CAD. Multivariate logistic regression analysis exhibited no significant association between these five polymorphisms and CAD risk in the genotype and allele frequencies. However, we found that the rs352493 polymorphism in SIRT6 exhibited a significant effect on the severity of CAD; C allele (χ(2) = 7.793, adjusted P = 0.013) and the combined CC/CT genotypes (χ(2) = 5.609, adjusted P = 0.031) presented the greater CAD severity. In addition, A allele (χ(2) = 5.208, adjusted P = 0.046) and AA (χ(2) = 4.842, adjusted P = 0.054) of rs3760908 were also associated with greater CAD severity in Chinese subjects. Our data provided the first evidence that SIRT6 tagSNPs rs352493 and rs3760908 play significant roles in the severity of CAD in Chinese Han subjects, which might be useful predictors of the severity of CAD.
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Sai-sai
SS
Tang
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Shun
S
Xu
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Jie
J
Cheng
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Meng-yun
MY
Cai
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Lin
L
Chen
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Li-li
LL
Liang
Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan 528000, China.
Xi-li
XL
Yang
Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Can
C
Chen
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Xin-guang
XG
Liu
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
Xing-dong
XD
Xiong
D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D037761:Sirtuins / Q000235:genetics*
C516592:SIRT6 protein, human; D037761:Sirtuins