NGF is Induced by Lidocaine in Human Skin Fibroblast Cells In Vitro.
We incubated skin fibroblasts with various concentrations of lidocaine for 3, 24, and 48 hours and found that the NGF mRNA expression levels significantly increased after incubation for 3 hours, indicating that the incubation for 3 hours activated the signaling that induce the NGF mRNA expression.
Tomoka
T
Matsumura
Kazumasa
K
Kubota
Kei
K
Sakamoto
Haruhisa
H
Fukayama
D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D020932:Nerve Growth Factor / Q000378:metabolism*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*
D020932:Nerve Growth Factor; D008012:Lidocaine