New isoindolinones from the fruiting bodies of Hericium erinaceum.
Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates. In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H. erinaceus. The structures of new compounds were validated by HRESIMS and 1D, 2D NMR. It's worth mentioning that there are two pairs of isomers included in the new compounds. Moreover, their cytotoxicity against metastatic human hepatocellular carcinoma cell lines SMMC-7221 and MHCC-97H were evaluated. The results showed that compounds 6 and 7 exhibited promising inhibitory potency against the growth of two cell lines.
Xiangya Hospital, Central South University, Changsha 410008, China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Xu-Li
XL
Wang
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Kang-Ping
KP
Xu
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Hong-Ping
HP
Long
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Hui
H
Zou
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Xiao-Zheng
XZ
Cao
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Kai
K
Zhang
Xiangya Hospital, Central South University, Changsha 410008, China.
Jian-Zhong
JZ
Hu
Hunan Xinhui Pharmaceutical Co., Ltd., Changsha 410200, China.
Shu-Jin
SJ
He
Haikou People's Hospital, Haikou 570208, China.
Gang-Zhi
GZ
Zhu
Haikou People's Hospital, Haikou 570208, China.
Xiao-Ai
XA
He
Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: xups2004@126.com.
Ping-Sheng
PS
Xu
Xiangya Hospital, Central South University, Changsha 410008, China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Electronic address: tgs395@csu.edu.cn.
Gui-Shan
GS
Tan
D000363:Agaricales / Q000737:chemistry; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification*; D054833:Isoindoles / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification
D007211:Indoles; D054833:Isoindoles; D010636:Phenols; C000613362:hericenone A; C535186:hericenone J
Cytotoxicity; Erinaceolactams A-E; Fruiting bodies; Hericium erinaceus; Isoindolinone