No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment.
Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Katharina
K
Bey
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Steffen
S
Wolfsgruber
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Ilker
I
Karaca
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Holger
H
Wagner
Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University, 6229 ER Maastricht, The Netherlands.
Roy
R
Lardenoije
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Julian
J
Becker
Department of Psychiatry & Psychotherapy, University of Cologne, 50937 Cologne, Germany.
Esther
E
Milz
Department of Psychiatry & Psychotherapy, Universitätsklinikum Erlangen, & Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Johannes
J
Kornhuber
Department of Psychiatry, Charité, 14050 Berlin, Germany.
Oliver
O
Peters
Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Lutz
L
Frölich
Centre for Geriatric Medicine & Section of Gerontopsychiatry & Neuropsychology, Medical School, University of Freiburg, 79106 Freiburg, Germany.
Michael
M
Hüll
Department of Psychiatry & Psychotherapy, University of Göttingen, 37075 Göttingen, Germany.
Eckart
E
Rüther
Department of Psychiatry & Psychotherapy, University of Göttingen, 37075 Göttingen, Germany.
Jens
J
Wiltfang
Institute of Social Medicine, Occupational Health & Public Health, University of Leipzig, 04103 Leipzig, Germany.
Steffi
S
Riedel-Heller
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Martin
M
Scherer
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.|Department of Psychiatry & Psychotherapy, University of Cologne, 50937 Cologne, Germany.
Frank
F
Jessen
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Wolfgang
W
Maier
Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University, 6229 ER Maastricht, The Netherlands.|Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics & Psychotherapy, University of Würzburg, 97080 Würzburg, Germany.
Daniel L
DL
van den Hove
Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University, 6229 ER Maastricht, The Netherlands.
Bart Pf
BP
Rutten
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Michael
M
Wagner
Department of Psychiatry & Psychotherapy, University of Bonn, 53127 Bonn, Germany.|Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
Alfredo
A
Ramirez
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D003071:Cognition; D060825:Cognitive Dysfunction / Q000235:genetics* / Q000523:psychology; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide
C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A
Alzheimer's disease; DNA methylation; DNA methyltransferase 3a; DNMT3A; MCI; aging; cognitive decline; epigenetics; mild cognitive impairment; rs11887120