New frontiers in translational control of the cancer genome.
The past several years have seen dramatic leaps in our understanding of how gene expression is rewired at the translation level during tumorigenesis to support the transformed phenotype. This work has been driven by an explosion in technological advances and is revealing previously unimagined regulatory mechanisms that dictate functional expression of the cancer genome. In this Review we discuss emerging trends and exciting new discoveries that reveal how this translational circuitry contributes to specific aspects of tumorigenesis and cancer cell function, with a particular focus on recent insights into the role of translational control in the adaptive response to oncogenic stress conditions.
Department of Urology, University of California, San Francisco.|Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94158, USA.
Morgan L
ML
Truitt
Department of Urology, University of California, San Francisco.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco.|Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94158, USA.
Davide
D
Ruggero
D016678:Genome; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D014176:Protein Biosynthesis; D012334:RNA, Neoplasm / Q000235:genetics
D012334:RNA, Neoplasm