Helicobacter pylori hopQalleles (type I and II) in gastric cancer.
TheHelicobacter pylori(H. pylori) outer membrane protein (HopQ) of is one of the proteins involved in bacterial adherence to gastric mucosa and has been suggested to have a role in the virulence ofH. pylori. The aim of the present study was to determine the association betweenH. pylorivirulence types I and IIhopQgenotypes and patients with different gastrointestinal diseases. A polymerase chain reaction-based assay was used to determine the presence of type I and type IIhopQgenes in 88H. pyloristrains isolated fromH. pylori-infected patients. Of the total 88H. pyloriisolates, type I and type IIhopQalleles were detected in 52 (59.1%) and 36 (40.9%), respectively. A significant association was found between type IhopQgene and gastric cancer [odds ratio, 2.3; 95% confidence interval (CI), 1.3-4.1] and gastric ulcers (odds ratio, 2.5; 95% CI, 1.4-4.3). A significant association was also identified between the type IIhopQgene and gastric cancer (odds ratio, 2.4; 95% CI, 1.1-3.0). The association betweenhopQtype I andhopQtype II genotypes and clinical status suggest that these genes may be helpful in the universal prediction of specific disease risks.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 51636-39888, Iran.
Hamed Ebrahimzadeh
HE
Leylabadlo
Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran.
Mina
M
Yekani
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 51636-39888, Iran; Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran.
Reza
R
Ghotaslou
Helicobacter pylori; outer membrane proteins; virulence factor