Diabetes Care After Transplant: Definitions, Risk Factors, and Clinical Management.
Patients who undergo solid organ transplantation may have preexisting diabetes mellitus (DM), develop new-onset DM after transplantation (NODAT), or have postoperative hyperglycemia that resolves shortly after surgery. Although insulin is usually used to control hyperglycemia in the hospital, following discharge most of the usual diabetes oral and parenteral medications can be used in treatment. However, when there are comorbidities such as impaired kidney or hepatic function, or heart disease, special precautions may be necessary. In addition, drug-drug interactions, such as drugs interacting with CYP3A4 enzyme pathway, require additional consideration because of possible interaction with immunosuppressive drug metabolism.
Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Amisha
A
Wallia
Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Vidhya
V
Illuri
Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: molitch@northwestern.edu.
Mark E
ME
Molitch
D000359:Aftercare; D003920:Diabetes Mellitus / Q000209:etiology / Q000628:therapy*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000628:therapy; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage; D016030:Kidney Transplantation; D016031:Liver Transplantation; D010351:Patient Discharge; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy*; D012307:Risk Factors
D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human
Diabetes; Immunosuppression; Insulin; Kidney; Liver; NODAT; Transplant; Transplantation