Associations of insulin receptor and insulin receptor substrates genetic polymorphisms with polycystic ovary syndrome: A systematic review and meta-analysis.
OBJECTIVE
Recently, the roles of insulin receptor (INSR) and insulin receptor substrate (IRS) polymorphisms in polycystic ovary syndrome (PCOS) have been extensively studied, with conflicting results. Therefore, we conducted the present systematic review and meta-analysis to better evaluate associations of INSR and IRS polymorphisms with PCOS.


METHODS
We searched PubMed, Medline, EMBASE, Google Scholar and China National Knowledge Infrastructure for eligible articles up to December 2015. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate associations of INSR and IRS polymorphisms with PCOS.


RESULTS
A total of 28 articles including 2975 PCOS patients and 3011 control subjects were analyzed. The overall analyses and subgroup analyses revealed that IRS-1 Gly972Arg polymorphism was significantly associated with PCOS for the Caucasian population in GG versus GA (OR = 0.57, 95%CI 0.37-0.89), GG versus GA + AA (OR = 0.57, 95%CI 0.36-0.89), GA versus GG + AA (OR = 1.74, 95%CI 1.13-2.69) and G versus A (OR = 0.63 95%CI 0.43-0.92). Also, IRS-2 Gly1057Asp polymorphism was significantly associated with PCOS for the Asian ethnicity in GG versus GA (OR = 0.45, 95%CI 0.24-0.83), GG versus AA (OR = 0.32, 95%CI 0.19-0.53), GG versus GA + AA (OR = 0.35, 95%CI 0.21-0.57), AA versus GG + GA (OR = 2.14, 95%CI 1.43-3.20), and G versus A (OR = 0.43, 95%CI 0.32-0.58). However, we detected no significant association between INSR His 1058 C/T polymorphism and PCOS.


CONCLUSIONS
Our findings suggest that IRS-1 Gly972Arg polymorphism is associated with PCOS in the Caucasian ethnicity, and IRS-2 Gly1057Asp polymorphism is correlated with PCOS in the Asian ethnicity. However, INSR His 1058 C/T polymorphism may not be implicated in PCOS. © 2016 Japan Society of Obstetrics and Gynecology.
Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, China.
Xiaohan
X
Shi
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Xiaochuan
X
Xie
Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, China.
Yingxian
Y
Jia
Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, China.
Shangwei
S
Li
D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic; D011972:Receptor, Insulin / Q000235:genetics*
C526292:IRS1 protein, human; C526297:IRS2 protein, human; D055504:Insulin Receptor Substrate Proteins; D011972:Receptor, Insulin
insulin receptor; insulin receptor substrate; insulin resistance; polycystic ovary syndrome; polymorphisms