The Ancient Evolutionary History of Polyomaviruses.
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billion years. Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages. The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae.
Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.
Christopher B
CB
Buck
Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, United States of America.
Koenraad
K
Van Doorslaer
Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.
Alberto
A
Peretti
Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.
Eileen M
EM
Geoghegan
Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.
Michael J
MJ
Tisza
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Ping
P
An
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Joshua P
JP
Katz
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
James M
JM
Pipas
Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, United States of America.
Alison A
AA
McBride
Department of Pathology, University of Georgia, Athens, Georgia, United States of America.
Alvin C
AC
Camus
Animal Health Department, Georgia Aquarium, Inc., Atlanta, Georgia, United States of America.
Alexa J
AJ
McDermott
Department of Pathology, University of Georgia, Athens, Georgia, United States of America.
Jennifer A
JA
Dill
Blood Systems Research Institute, San Francisco, California, United States of America.|Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America.
Eric
E
Delwart
Blood Systems Research Institute, San Francisco, California, United States of America.|Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America.
Terry F F
TF
Ng
School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Kata
K
Farkas
School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Charlotte
C
Austin
School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Simona
S
Kraberger
School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
William
W
Davison
Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.
Diana V
DV
Pastrana
School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.|Structural Biology Research Unit, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa.|Department of Plant Pathology and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
Arvind
A
Varsani
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D005399:Fishes; D006790:Host-Parasite Interactions / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D011120:Polyomavirus / Q000235:genetics*; D012605:Scorpions; D012756:Sheep