α-Tocopherol supplementation and the oxidative stress, homocysteine, and antioxidants in lead exposure.
To investigate whether α-tocopherol supplementation in workers exposed to lead would reduce the oxidative stress intensity and decrease homocysteine level, the examined population was randomly divided into two groups. Workers in the first group (n = 49, reference group) were not administered any drugs. Workers in the second group (n = 34) were administered orally α-tocopherol, 200 mg per day for 12 weeks. The level of α-tocopherol significantly increased compared to the baseline and the reference group. The level of thiol groups significantly increased compared to the reference group. However, the levels of malondialdehyde and homocysteine did not significantly change. Animal studies suggest the ability of α-tocopherol administration to reverse adverse health effects of lead exposure, such as oxidative stress; however, the results of this study on humans do not confirm these protective effects.
a Department of Biochemistry , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice , Poland.
Sławomir
S
Kasperczyk
a Department of Biochemistry , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice , Poland.
Michał
M
Dobrakowski
a Department of Biochemistry , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice , Poland.
Aleksandra
A
Kasperczyk
b Higher School of Medicine , Sosnowiec , Poland.
Ewa
E
Nogaj
c Institute of Occupational Medicine and Environmental Health , Sosnowiec , Poland.
Marta
M
Boroń
d Upper Silesian Rehabilitation Centre Repty , Tarnowskie Góry , Poland.
Zbigniew
Z
Szlacheta
a Department of Biochemistry , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice , Poland.
Ewa
E
Birkner
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology*; D006710:Homocysteine / Q000097:blood / Q000187:drug effects*; D006801:Humans; D007855:Lead Poisoning / Q000150:complications*; D008875:Middle Aged; D016273:Occupational Exposure; D018384:Oxidative Stress / Q000187:drug effects*; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000494:pharmacology*
D000975:Antioxidants; D006710:Homocysteine; D024502:alpha-Tocopherol
antioxidants; homocysteine; lead poisoning; lipid peroxidation; oxidative stress; α-Tocopherol