Coptis chinensis Polysaccharides Inhibit Advanced Glycation End Product Formation.
Coptis chinensis Franch (Huanglian) is commonly used to treat diabetes in China. In this study, the effects of the C. chinensis Franch polysaccharides (CCP) on advanced glycation end product (AGE) formation in vitro and in streptozotocin-induced diabetic mice were investigated. CCP significantly inhibited all the three periods of nonenzymatic protein glycation in vitro, including Amadori product, dicarbonyl compound, and AGE formation (P < .01). In diabetic mice, the administration of CCP not only improved both bodyweight and serum insulin and decreased fasting blood glucose and glycated serum protein concentrations but also decreased the AGE accumulations and morphological abnormalities in pancreas and liver. The inhibitory effects of CCP on AGE formation afford a potential therapeutic use in the prevention and treatment of diabetes.
1 School of Pharmacy, Anhui University of Chinese Medicine , Hefei, China .
Ye
Y
Yang
1 School of Pharmacy, Anhui University of Chinese Medicine , Hefei, China .
Yun
Y
Li
1 School of Pharmacy, Anhui University of Chinese Medicine , Hefei, China .
Dengke
D
Yin
2 State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing, China .
Song
S
Chen
2 State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing, China .
Xiangdong
X
Gao
D000818:Animals; D039323:Coptis / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage*
D017127:Glycation End Products, Advanced; D007328:Insulin; D010936:Plant Extracts; D011134:Polysaccharides
Coptis chinensis Franch; advanced glycation end products; diabetes; polysaccharide