Hyaluronan-Itaconic Acid-Glutaraldehyde Films for Biomedical Applications: Preliminary Studies.
New hyaluronic acid-itaconic acid films were synthesized as potential materials with biomedical applications. In this work, we explored the homogeneous cross-linking reactions of hyaluronic acid using glutaraldehyde in the presence of itaconic acid and triacetin as plasticizers. Biomechanical properties were assessed in terms of stability by measuring swelling in aqueous environments, investigating wettability using contact angle tests, and evaluating bioadhesive performance. The ductility of the materials was evaluated through stress-strain measurements and the morphology was explored by scanning electron microscopy. The results show that the incorporation of itaconic acid improved most of the desirable properties, increasing adhesiveness and reducing wettability and swelling. The use of triacetin enhanced the strength, bioadhesiveness, and ductility of the material.
PLAPIQUI-CONICET, Universidad Nacional del Sur, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina; Dpto Biología Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina; Institute of Applied Ophthalmobiology, University of Valladolid, Paseo de Belén 17, 47011, Valladolid, Spain.
Javier Adrián
JA
Calles
PLAPIQUI-CONICET, Universidad Nacional del Sur, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina; Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC), 1900, La Plata, Argentina.
Jorge Aníbal
JA
Ressia
UNITEFA-CONICET, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, X5000HUA, Córdoba, Argentina.
Juan Manuel
JM
Llabot
PLAPIQUI-CONICET, Universidad Nacional del Sur, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina.
Enrique Marcelo
EM
Vallés
UNITEFA-CONICET, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, X5000HUA, Córdoba, Argentina.
Santiago Daniel
SD
Palma
Biomaterials; Cross-link; Hyaluronan; Polymers