Advancing Tissue Engineering: A Tale of Nano-, Micro-, and Macroscale Integration.
Tissue engineering has the potential to revolutionize the health care industry. Delivering on this promise requires the generation of efficient, controllable and predictable implants. The integration of nano- and microtechnologies into macroscale regenerative biomaterials plays an essential role in the generation of such implants, by enabling spatiotemporal control of the cellular microenvironment. Here we review the role, function and progress of a wide range of nano- and microtechnologies that are driving the advancements in the field of tissue engineering.
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Jeroen
J
Leijten
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
Jeroen
J
Rouwkema
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
Yu Shrike
YS
Zhang
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Amir
A
Nasajpour
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
Mehmet Remzi
MR
Dokmeci
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea.|Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.
Ali
A
Khademhosseini
D001672:Biocompatible Materials / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry; D060833:Cellular Microenvironment; D004247:DNA / Q000737:chemistry; D005782:Gels; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D007700:Kinetics; D044085:Microfluidics; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D010982:Platelet-Derived Growth Factor / Q000737:chemistry; D012038:Regeneration; D055672:Static Electricity; D019809:Streptavidin / Q000737:chemistry; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds / Q000737:chemistry; D042461:Vascular Endothelial Growth Factor A / Q000737:chemistry; D014783:Viscosity
D001672:Biocompatible Materials; D005782:Gels; D020100:Hydrogels; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; D001710:Biotin; D004247:DNA; D019809:Streptavidin
biomimetics; microenvironments; microfluidics; micromaterials; tissue engineering