Neuroleptic malignant syndrome and subsequent clozapine-withdrawal effects in a patient with refractory schizophrenia.
Here, we report a female patient developing neuroleptic malignant syndrome following the use of a combination of clozapine and haloperidol. Subsequently, the patient presented withdrawal effects after an abrupt discontinuation of clozapine. Psychiatrists not aware of possible clozapine-withdrawal effects may misdiagnose as a part of the primary mental illness or as the initial symptoms worsening, if unrecognized.
Department of Psychiatry, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Minfeng
M
Cheng
Department of Psychiatry, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Huaying
H
Gu
Department of Psychiatry, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Liangrong
L
Zheng
Department of Psychiatry, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Houliang
H
Wang
Department of Psychiatry, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Zhiyong
Z
Zhong
Department of Psychiatry, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Shenglin
S
Wen
clozapine; neuroleptic malignant syndrome; schizophrenia; withdrawal effect