Primary ciliary dyskinesia in two English Cocker Spaniels.
BACKGROUND
Primary ciliary dyskinesia (PCD) is an inherited condition characterised by structural and functional defects of ciliated cells. Ciliated cells are present in several different anatomic locations and PCD can thus cause a variety of clinical signs; however, the predominant clinical signs in dogs are respiratory in nature, most commonly chronic nasal discharge and recurrent lower respiratory tract infections commencing in the neonatal period.
This report describes two cases of PCD in English Cocker Spaniel puppies presenting with chronic nasal discharge and bronchopneumonia. We describe the use of a minimally invasive technique to collect samples suitable for cilial studies for its diagnosis.
Translational Research and Animal Clinical Trial Study (TRACTS) Group, Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia. belle@unimelb.edu.au.
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ET
Bell
PCD Diagnostic Service, Respiratory Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
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P
Griffin
PCD Diagnostic Service, Respiratory Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
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P
Martinello
PCD Diagnostic Service, Respiratory Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.|Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.|Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia.
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P
Robinson
congenital diseases; dogs; respiratory medicine