Control of electrochemical signals from quantum dots conjugated to organic materials by using DNA structure in an analog logic gate.
Various bio-logic gates have been studied intensively to overcome the rigidity of single-function silicon-based logic devices arising from combinations of various gates. Here, a simple control tool using electrochemical signals from quantum dots (QDs) was constructed using DNA and organic materials for multiple logic functions. The electrochemical redox current generated from QDs was controlled by the DNA structure. DNA structure, in turn, was dependent on the components (organic materials) and the input signal (pH). Independent electrochemical signals from two different logic units containing QDs were merged into a single analog-type logic gate, which was controlled by two inputs. We applied this electrochemical biodevice to a simple logic system and achieved various logic functions from the controlled pH input sets. This could be further improved by choosing QDs, ionic conditions, or DNA sequences. This research provides a feasible method for fabricating an artificial intelligence system.
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, Republic of Korea.
Qi
Q
Chen
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, Republic of Korea.
Si-Youl
SY
Yoo
Department of Chemical Engineering, Hoseo University, Hoseoro 79 bungil 20, Baebang, Asan, Chungnam 336-795, Republic of Korea.
Yong-Ho
YH
Chung
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, Republic of Korea.
Ji-Young
JY
Lee
School of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 156-756, Republic of Korea. Electronic address: junmin@cau.ac.kr.
Junhong
J
Min
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, Republic of Korea; Interdisciplinary Program of Integrated Biotechnology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, Republic of Korea. Electronic address: jwchoi@sogang.ac.kr.
Jeong-Woo
JW
Choi
D001483:Base Sequence; D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D055615:Electrical Equipment and Supplies; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D008128:Logic; D009930:Organic Chemicals / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*
D009930:Organic Chemicals; D004247:DNA
Analog-type logical output; Environments; Flexible logic functions; Quantum dots; Redox current