Live Birth from ICSI-TESA into In Vitro Matured Oocytes: A Case Report.
BACKGROUND
Repeated in vitro Fertilization (IVF) failure together with Ovarian Hyperstimulation Syndrome (OHSS) is one of the distressing situations leading couples to search for alternative treatment options. For such patients with Polycystic Ovarian Syndrome (PCOS) who have experienced Ovarian Hyperstimulation Syndrome, mild ovarian stimulation with in vitro oocyte maturation could be a promising alternative. Testicular Sperm Aspiration (TESA) of spermatozoa from a known obstructive azoospermic patient is a limiting factor for IVM (in vitro maturation) but the couple reported here accepted mild IVF -IVM with TESA.


METHODS
In the treatment of a 32-year old woman, 9 immature oocytes were retrieved, 5 in vitro matured oocytes (maturation rate 55%) and after fertilization by Intracytoplasmic Sperm Injection (ICSI), 3 oocytes (fertilization rate 60%) which had two pronuclei and two good quality embryos on day 2, were transferred. A live pregnancy was observed by ultrasound scan and healthy infant was delivered.


CONCLUSIONS
Although the number of births from ICSI of immature oocytes injected with surgically derived sperm is quite low, the selection of this mode of therapy as an alternative to conventional IVF will overcome the limitations and provides a new option in IVF practice.
Clinart IVF Center, Trabzon, Turkey.
Şafak
Ş
Hatırnaz
Clinart IVF Center, Trabzon, Turkey.
Ebru
E
Hatırnaz
Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, School of Medicine, Kahramanmaraş, Turkey.
Murat
M
Bakacak
Department of Obstetrics and Gynecology, Sakarya University Research and Education Hospital, Sakarya, Turkey.
Mehmet Sühha
MS
Bostancı
Department of Obstetrics and Gynecology, Giresun University, School of Medicine, Giresun, Turkey.
Melahat
M
Atasever
In vitro maturation; Oocytes; Pregnancy; Testicular sperm aspiration