Two new compounds from the roots of Ilex pubescens and their cytotoxic activity.
A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots of Ilex pubescens. Their chemical structures were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, MS, and NMR experiments. In addition, compounds 2-7 were evaluated in vitro for their cytotoxic effects on human HeLa cells; among them, compounds 2, 3, 6, and 7 showed cytotoxic activity against HeLa cells in the test.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Huan
H
Xiong
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Fang
F
Zhao
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Jiayi
J
Bi
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Yang
Y
Zhang
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Guiyun
G
Zhao
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Xue
X
Chen
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Yuncong
Y
Li
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Rui
R
Yan
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Qiang
Q
Zhao
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China.
Hua
H
Qiao
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang, 110016, People's Republic of China. zggth@163.com.
Guogang
G
Zhang
D006367:HeLa Cells; D006801:Humans; D030017:Ilex / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
Cytotoxic activity; Ilex pubescens; Lignans; Phenylethanoid