High-field dissolution dynamic nuclear polarization of [1-(13)C]pyruvic acid.
[1-(13)C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-(13)C]pyruvic acid, unextrapolated solution-state (13)C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.
Institute of Physics of Biological Systems, Swiss Federal Institute of Technology, Lausanne, Switzerland. hikari.yoshihara@epfl.ch.
Hikari A I
HA
Yoshihara
Emine
E
Can
Magnus
M
Karlsson
Mathilde H
MH
Lerche
Juerg
J
Schwitter
Arnaud
A
Comment
D002247:Carbon Isotopes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D019289:Pyruvic Acid / Q000737:chemistry*
D002247:Carbon Isotopes; D019289:Pyruvic Acid; D005682:Gadolinium