BDNF gene polymorphisms and haplotypes in relation to cognitive performance in Polish healthy subjects.
The brain derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in the cell survival, axonal and dendritic growth, and synaptic plasticity. BDNF gene polymorphisms, 'functional Val66Met mainly, were shown to influence human brain structure and cognition. The aim of the study was to assess the relationship between twelve BDNF gene variants and their haplotypes and cognitive performance measured using the Wisconsin Card Sorting Test (WCST), the Trail Making Test (TMT), the Stroop Test which are to a large extent connected with prefrontal cortex activity. Our sample consisted of 460 healthy participants from Polish population. We detected possible association between five BDNF polymorphisms (rs11030101, rs10835210, rs2049046, rs2030324, rs2883187) and TMT_A. Additionally, one haplotype block made from eleven BDNF variants (rs2883187, rs1401635, rs2049046, rs2030324, rs11030101, rs10835210, rs1013402, rs1401635, rs1013402), as significant linkage disequilibrium appeared. We discovered possible relationships of CACCGCGTACG and CACCGCGTACG haplotypes with TMT_A and TMT_B performance respectively. Our results confirmed the involvement of BDNF in the regulation of psychomotor speed, working memory and executive function in healthy subjects measured by a task engaging visuoperceptual abilities.
Institute of Psychology, Kazimierz Wielki University in Bydgoszcz, Poland; monikawilkosc@gmail.com.
Monika
M
Wiłkość
Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland;
Agnieszka
A
Szałkowska
Psychiatry Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poznań, Poland;
Maria
M
Skibińska
Institute of Psychology, Kazimierz Wielki University in Bydgoszcz, Poland;
Ludmiła
L
Zając-Lamparska
Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada;
Małgorzata
M
Maciukiewicz
Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland;
Aleksander
A
Araszkiewicz
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003071:Cognition; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D064368:Healthy Volunteers; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011044:Poland; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human