Facile synthesis of monodisperse of hollow mesoporous SiO2 nanoparticles and in-situ growth of Ag nanoparticles for antibacterial.
Monodispersed hollow mesoporous silica nanoparticles (HMSNs) are successfully synthesized via a facile dual template method, in which poly(styrene-co-methyl methacrylate-co-methacrylic acid) (PS-PMMA-PMAA) particles are used as hard template for producing the hollow structure and cetyltrimethylammonium bromide (CTAB) used for introducing the mesopores in the silica shells. The obtained HMSNs possess uniform diameter and morphology, and the shell of which could be adjusted by changing the addition of silicon precursor. The synthesized HMSNs have been characterized by transmission electron microscopy (TEM) and nitrogen physisorption. Furthermore, the HMSNs are used as support for in-situ deposition of silver nanoparticles (Ag NPs) using n-butylamine as reducing agent for AgNO3 in ethanol. Significantly, Ag NPs were successfully supported in the HMSNs without any aggregation. The Ag-deposited HMSNs showed excellent dispersibility in ethanol and water, and their antibacterial activity against Escherichia coli (E. coli) ATCC 25922 and Staphylococcus aureus (S. aureus) ATCC 6538 have been demonstrated. Therefore, the unique nanostructure based on the HMSNs provided a useful platform for the fabrication of antibacterial agent with superior activity and accessibility. And also, it is expected to be a significant template for the synthesis of other novel nanostructures.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Peng
P
Xu
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Juan
J
Liang
College of Forestry, Nanjing Forestry University, Nanjing 210037, China.
Xiaoyong
X
Cao
Nanjing Institute of Supervision & Testing on Product Quality, Nanjing 210028, China.
Jingen
J
Tang
Nanjing Institute of Supervision & Testing on Product Quality, Nanjing 210028, China.
Juan
J
Gao
Nanjing Institute of Supervision & Testing on Product Quality, Nanjing 210028, China.
Liying
L
Wang
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Wei
W
Shao
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Qinwei
Q
Gao
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China. Electronic address: zhaogangteng@163.com.
Zhaogang
Z
Teng
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D012834:Silver; D012822:Silicon Dioxide
Ag; Antibacterial; Hollow; Mesoporous silica; Template