Exploitation of lipid-polymeric matrices at nanoscale for drug delivery applications.
Progress in drug delivery and a better quality of life for patients, relies on the development of new and suitable drug carrier systems, with unequivocal therapeutic benefits, low systemic toxicity and reduced side effects. Lipid-polymeric nanoparticles have been explored to produce nanocarriers due to their features and applications such as high drug entrapment, physical-chemical stability and controlled release properties.



In this review, we describe several hybrid nanoparticles obtained from mixing a polymer with a lipid matrix. This association can potentiate the efficacy of drug delivery systems, due to the enhancement of encapsulation efficiency and loading capacity, tailoring the drug release according to the therapeutic purpose, and improving the drug uptake by targeting it to specific receptors. Contrary to lipid nanoparticles, these hybrid nanoparticles can decrease the initial burst release and promote a more sustained and localized release of the drug.



Lipid-polymeric nanoparticles are versatile vehicles for drug delivery by different administration routes in the treatment of multiple diseases. Different solid lipids, polymers, surfactants and techniques for producing these carriers have been investigated, revealing the importance of their composition to achieve optimal characteristics to drug delivery.
a Centro de Ciências Médicas e Farmacêuticas , Universidade Estadual do Oeste do Paraná , Cascavel , Brasil.
Débora
D
Sgorla
a Centro de Ciências Médicas e Farmacêuticas , Universidade Estadual do Oeste do Paraná , Cascavel , Brasil.
Élcio J
ÉJ
Bunhak
b Departamento de Farmacologia e Terapêutica , Universidade Estadual de Maringá , Maringá , Brasil.
Osvaldo A
OA
Cavalcanti
c UCIBIO, REQUIMTE, Department of Chemical Sciences - Applied Chemistry Lab, Faculty of Pharmacy , University of Porto , Porto , Portugal.|d CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde and Instituto Universitário de Ciências da Saúde , Gandra-PRD , Portugal.
Pedro
P
Fonte
a Centro de Ciências Médicas e Farmacêuticas , Universidade Estadual do Oeste do Paraná , Cascavel , Brasil.|d CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde and Instituto Universitário de Ciências da Saúde , Gandra-PRD , Portugal.|e i3S, Instituto de Investigação e Inovação em Saúde , Universidade do Porto , Portugal.|f INEB - Instituto de Engenharia Biomédica , Universidade do Porto , Porto , Portugal.
Bruno
B
Sarmento
D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*; D011788:Quality of Life; D013501:Surface-Active Agents / Q000737:chemistry
D004337:Drug Carriers; D005079:Excipients; D008055:Lipids; D011108:Polymers; D013501:Surface-Active Agents
Hybrid nanoparticle; lipid; lipid-polymeric nanoparticle; nanoparticle; polymer