Micronutrient Intakes and Incidence of Chronic Kidney Disease in Adults: Tehran Lipid and Glucose Study.
The aim of this study was to investigate the associations between micronutrient intakes and the 3.6-year incidence of chronic kidney disease (CKD) in adults. This cohort study was conducted, within the framework of the Tehran Lipid and Glucose Study, on 1692 subjects, aged ≥30 years, without CKD at the baseline. Dietary intakes were collected using a valid and reliable food-frequency questionnaire. Anthropometrics and biochemical measurements were taken. Chronic kidney disease was defined as eGFR < 60 mL/min/1.73 m². The mean age of participants was 43.3 ± 11.4 years. In the fully adjusted model, individuals in the top quintile of folate (OR: 0.44, 95% CI: 0.24-0.80), cobalamin (OR: 0.57, 95% CI: 0.34-0.93), vitamin C (OR: 0.38, 95% CI: 0.21-0.69), vitamin E (OR: 0.45, 95% CI: 0.22-0.92), vitamin D (OR: 0.39, 95% CI: 0.21-0.70), potassium (OR: 0.47, 95% CI: 0.23-0.97) and magnesium (OR: 0.41, 95% CI: 0.22-0.76) had decreased risk of CKD, and in the top quintile of sodium (OR: 1.64, 95% CI: 1.03-2.61), subjects had increased risk of CKD, in comparison to the bottom quintile. No significant associations were found between the intakes of other micronutrients. High intake of several micronutrients including vitamins C, E, D, cobalamin, folate, magnesium, and potassium was associated with a decreased risk, while sodium was associated with an increased risk of incident CKD.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 19395-4763, Iran. hosein.farhadnejad@gmail.com.
Hossein
H
Farhadnejad
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 19395-4763, Iran. g_asghari@hotmail.com.
Golaleh
G
Asghari
Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran 19395-4741, Iran. mirmiran@endocrine.ac.ir.
Parvin
P
Mirmiran
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 19395-4763, Iran. e_yuzbashian@yahoo.com.
Emad
E
Yuzbashian
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 19395-4763, Iran. azizi@endocrine.ac.ir.
Fereidoun
F
Azizi
D000328:Adult; D001786:Blood Glucose; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D018977:Micronutrients / Q000378:metabolism / Q000494:pharmacology*; D008875:Middle Aged; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000378:metabolism*; D012307:Risk Factors
D001786:Blood Glucose; D008055:Lipids; D018977:Micronutrients
chronic kidney disease; micronutrients; minerals; vitamins