Eosinophil-Rich Acute Febrile Neutrophilic Dermatosis in a Patient With Enteropathy-Associated T-cell Lymphoma, Type 1.
The presence of eosinophils within the neutrophilic infiltrates of acute febrile neutrophilic dermatosis (Sweet syndrome) is documented in the literature. Here, the authors describe a case of eosinophil-rich acute febrile neutrophilic dermatosis in the setting of new onset enteropathy-associated T-cell lymphoma (EATL), type 1. Histopathologic evaluation of the skin biopsies demonstrated a mixed superficial perivascular and inflammatory infiltrate composed of neutrophils, lymphocytes, and abundant eosinophils. EATL, type 1 is an aggressive although rare primary intestinal lymphoma that may be associated with celiac disease. This lymphoma is associated with a poor prognosis due to treatment resistance or bowel perforation. To the authors' knowledge, Sweet syndrome has not been reported in a patient with EATL.
*Department of Pathology, Stanford University Medical University, Stanford, CA; †Adaptive Biotechnologies, Seattle, WA; and ‡Department of Dermatology, Stanford University Medical University, Stanford, CA.
Christopher W
CW
Soon
Ilan R
IR
Kirsch
Andrew J
AJ
Connolly
Bernice Y
BY
Kwong
Jinah
J
Kim
D000369:Aged, 80 and over; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D016463:Sweet Syndrome / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology