Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members.
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Chelsea L
CL
Loughner
HUGO Gene Nomenclature Committee (HGNC), European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
Elspeth A
EA
Bruford
Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Monica S
MS
McAndrews
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Emili E
EE
Delp
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Sudha
S
Swamynathan
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA. Swamynathansk@upmc.edu.|Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, USA. Swamynathansk@upmc.edu.|McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA. Swamynathansk@upmc.edu.|Fox Center for Vision Restoration, University of Pittsburgh School of Medicine, Pittsburgh, USA. Swamynathansk@upmc.edu.|Eye and Ear Institute, University of Pittsburgh School of Medicine, 203 Lothrop Street, Room 1025, Pittsburgh, PA, 15213, USA. Swamynathansk@upmc.edu.
Shivalingappa K
SK
Swamynathan
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D051379:Mice; D005810:Multigene Family / Q000235:genetics*; D009504:Neutrophils; D000072417:Protein Domains; D055293:Receptors, Urokinase Plasminogen Activator / Q000235:genetics*; D015398:Signal Transduction
D000950:Antigens, Ly; C526827:Ly6 protein, mouse; D055293:Receptors, Urokinase Plasminogen Activator
LU domain; Ly6/uPAR family; Lymphocytes; Neutrophils; Three-finger domain; uPAR