Validation of PI-RADS v.2 for prostate cancer diagnosis with MRI at 3T using an external phased-array coil.
To date, few studies have validated the Prostate Imaging Reporting and Data System Version 2 (PI-RADS v. 2) for the diagnosis of prostate cancer. Our aim was to validate PI-RADS v.2 using 3 Tesla (T) MRI.



This is a retrospective study of 54 consecutive patients who underwent 3T MRI with a body-array coil for diagnostic confirmation of prostate cancer or cancer staging between June 2013 and June 2015. Sensitivity, specificity, and agreement were calculated based on a criterion of PI-RADS score = 3. Inter-examiner agreement was determined by the weighted kappa statistic.



Histological findings were positive for cancer in 33 patients and negative in 21 patients. Considering a PI-RADS score of 3 as positive for cancer, the accuracy of each reader was 85.20% and 70.40%, respectively, and agreement coefficients were κ = 0.69 and κ = 0.35. Considering PI-RADS 3 as absence of cancer, the accuracy of each reader was 77.80% and 77.80%, respectively, and agreement was κ = 0.55 and κ = 0.54. Inter-reader agreement was moderate/good (weighted κ = 0.53; 95% confidence interval: 0.39-0.66; P = 0.038).



High accuracy was obtained for the diagnosis of prostate cancer using 3T MRI with a body coil and the PI-RADS v.2 score. J. Magn. Reson. Imaging 2016;44:1354-1359.
School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) and Department of Radiology, Center for Molecular Imaging, PUCRS Brain Institute, Porto Alegre, RS, Brazil. matteob@terra.com.br.
Matteo
M
Baldisserotto
Department of Urologic Surgery, School of Medicine, PUCRS; Urologist, Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Eurico J Dornelles
EJ
Neto
Department of Urologic Surgery, School of Medicine, PUCRS; Urologist, Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Gustavo
G
Carvalhal
Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Aloyso F
AF
de Toledo
Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Clovis M
CM
de Almeida
Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Carlos E D
CE
Cairoli
Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Daniel O
DO
de Silva
Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Eduardo
E
Carvalhal
Department of Radiology, Center for Molecular Imaging, PUCRS Brain Institute, Porto Alegre, RS, Brazil.
Ricardo P
RP
Paganin
Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Alexandre
A
Agra
School of Medicine, PUCRS, Porto Alegre, RS, Brazil.
Francisco S
FS
de Santos
Department of Urologic Surgery, School of Medicine, PUCRS; Urologist, Urology Service, Hospital São Lucas (HSL), PUCRS, Porto Alegre, RS, Brazil.
Jorge A P
JA
Noronha
D000368:Aged; D000369:Aged, 80 and over; D004867:Equipment Design; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000592:standards*; D038622:Internationality; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000592:standards*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D011829:Radiation Dosage; D011873:Radiology Information Systems / Q000592:standards*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers / Q000592:standards*
magnetic resonance imaging; prostate cancer; scoring method; validation studies