Rasch analysis of the Pediatric Evaluation of Disability Inventory-computer adaptive test (PEDI-CAT) item bank for children and young adults with spinal muscular atrophy.
In this study we evaluated the suitability of a caregiver-reported functional measure, the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT), for children and young adults with spinal muscular atrophy (SMA).



PEDI-CAT Mobility and Daily Activities domain item banks were administered to 58 caregivers of children and young adults with SMA. Rasch analysis was used to evaluate test properties across SMA types.



Unidimensional content for each domain was confirmed. The PEDI-CAT was most informative for type III SMA, with ability levels distributed close to 0.0 logits in both domains. It was less informative for types I and II SMA, especially for mobility skills. Item and person abilities were not distributed evenly across all types.



The PEDI-CAT may be used to measure functional performance in SMA, but additional items are needed to identify small changes in function and best represent the abilities of all types of SMA. Muscle Nerve 54: 1097-1107, 2016.
Department of Physical Therapy and Occupational Therapy Services, 300 Longwood Avenue, Boston Children's Hospital, Boston, Massachusetts, USA.
Amy
A
Pasternak
Clinical Research Center, Department of Medicine and Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Georgios
G
Sideridis
Research Center for Children with Special Health Care Needs, Franciscan Hospital for Children, Brighton, Massachusetts, USA.
Maria
M
Fragala-Pinkham
Department of Physical Therapy, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Allan M
AM
Glanzman
Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, New York, USA.|Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Jacqueline
J
Montes
Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, New York, USA.|Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Sally
S
Dunaway
Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Rachel
R
Salazar
Department of Physical Therapy and Occupational Therapy Services, 300 Longwood Avenue, Boston Children's Hospital, Boston, Massachusetts, USA.
Janet
J
Quigley
Department of Neurology, University of Rochester, Rochester, New York, USA.
Shree
S
Pandya
Department of Physical and Occupational Therapy, Massachusetts General Hospital, Boston, Massachusetts, USA.
Susan
S
O'Riley
Department of Physical Therapy and Occupational Therapy Services, 300 Longwood Avenue, Boston Children's Hospital, Boston, Massachusetts, USA.
Jonathan
J
Greenwood
Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Claudia
C
Chiriboga
Department of Pediatrics, Nemours Children's Hospital, Orlando, Florida, USA.
Richard
R
Finkel
Department of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.|Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Gihan
G
Tennekoon
Department of Neurology, University of Rochester, Rochester, New York, USA.
William B
WB
Martens
Department of Neurology, University of Rochester, Rochester, New York, USA.|Department of Biostatistics and Computational Biology, University of Rochester, New York, USA.
Michael P
MP
McDermott
Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Heather Szelag
HS
Fournier
Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lavanya
L
Madabusi
Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Timothy
T
Harrington
Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Rosangel E
RE
Cruz
Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Nicole M
NM
LaMarca
Department of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.|Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Nancy M
NM
Videon
Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Darryl C De
DC
Vivo
Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Basil T
BT
Darras
D000203:Activities of Daily Living; D000293:Adolescent; D017028:Caregivers / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003936:Diagnosis, Computer-Assisted; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008124:Locomotion; D008297:Male; D051346:Mobility Limitation; D009134:Muscular Atrophy, Spinal / Q000175:diagnosis* / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care; D015203:Reproducibility of Results; D013269:Stochastic Processes; D055815:Young Adult
Pediatric Evaluation of Disability Inventory-Computer Adaptive Test; Rasch analysis; capacity measures; caregiver-reported outcome measures; computer adaptive testing; spinal muscular atrophy