Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity.
Developing vaccine formulations with excellent thermostability and immunogenicity remains a great challenge. By in situ encapsulating a live-attenuated strain of human enterovirus 71 (EV71) in alumina, we obtained a robust vaccine formulation named EV71@NanoAlum, which features significantly enhanced thermostability and immunogenicity. This attempt follows a material-based tactic for vaccine improvement.
Center for Biomaterials and Biopathways, Zhejiang University, Hangzhou 310027, China. rtang@zju.edu.cn.
Hangyu
H
Zhou
Guangchuan
G
Wang
Xiao-Feng
XF
Li
Yaling
Y
Li
Shun-Ya
SY
Zhu
Cheng-Feng
CF
Qin
Ruikang
R
Tang
D000537:Aluminum Oxide / Q000737:chemistry* / Q000276:immunology; D029821:Enterovirus A, Human / Q000737:chemistry* / Q000276:immunology; D000071497:Immunogenicity, Vaccine / Q000276:immunology*; D010316:Particle Size; D055550:Protein Stability; D013696:Temperature; D014612:Vaccines / Q000737:chemistry* / Q000276:immunology*
D014612:Vaccines; D000537:Aluminum Oxide