Syncytial Variant of Nodular Sclerosis Classical Hodgkin Lymphoma of the Terminal Ileum in a Patient with Longstanding Crohn's Disease.
Primary Hodgkin lymphoma of the gastrointestinal tract is an uncommon malignancy with few reported cases. Here we describe a rare variant of Hodgkin lymphoma presented in the gastrointestinal tract in association with Crohn's Disease.The patient is a 58 year old male with a 40 year history of formerly well-controlled Crohn's disease who presented with abdominal discomfort and constitutional symptoms. Computed tomography showed a 10 cm thickened segment of ileum and a dilated segment of small bowel. The patient underwent segmental resection, revealing a mass, which was diagnosed by pathology as nodular sclerosis classical Hodgkin lymphoma, syncytial variant.There are only 29 reported cases of syncytial variant of nodular sclerosis classical Hodgkin lymphoma. This is the second documented case of primary gastrointestinal syncytial variant of nodular sclerosis classical Hodgkin lymphoma. Further characterization of this entity is necessary.
Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA bradgibson1987@gmail.com.
Bradley
B
Gibson
Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.
Mirna Bajramovic
MB
Podoll
Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.
Erin Marie
EM
Baumgartner
Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.
Diana Haninger
DH
Maley
D003424:Crohn Disease / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D015726:Giant Cells / Q000473:pathology*; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007082:Ileum / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012598:Sclerosis