Oxygen Uptake Attenuation at Ventilatory Threshold in Men With Coronary Artery Disease.
OBJECTIVE
Maximal oxygen uptake ((Equation is included in full-text article.)O2) and ventilatory threshold (VT) are widely used to assess cardiorespiratory fitness in healthy people, as well as in patients with various clinical conditions. The aim of this study was to determine whether an attenuation of (Equation is included in full-text article.)O2 occurs above the VT in patients with stable coronary artery disease.


METHODS
A total of 33 male patients participating in an outpatient cardiac rehabilitation/secondary prevention program underwent maximal incremental cycle ergometry at increasing pedaling cadences up to the limit of tolerance. Ventilatory gas-exchange variables were measured breath by breath while work rate was recorded continuously. Ventilatory threshold was determined by a dual linear regression model (V-slope analysis).


RESULTS
Four patients were excluded from the analysis because they were unable to pedal at the increasing cadences required by the protocol. The remaining 29 patients successfully completed the test without complications or evidence of significant ST segment depression. The slope of the (Equation is included in full-text article.)O2/work rate relationship above the VT decreased significantly (-44.6% on average) in 23 of the 26 patients in which VT was able to be determined. (Equation is included in full-text article.)O2 at the start of (Equation is included in full-text article.)O2 attenuation ((Equation is included in full-text article.)O2att) and at VT were highly correlated and in strong agreement (1637 ± 451 mL/min vs 1650 ± 473 mL/min, r = 0.96, P < .01).


CONCLUSIONS
(Equation is included in full-text article.)O2att does occur and coincides with the VT in the majority of patients tested with stable coronary artery disease.
Department of Biomedical Sciences and Surgical Specialties (Drs Uliari, Bernardi, Chiaranda, Conconi, Terranova, Mazzoni, and Grazzi), University of Ferrara, Ferrara, Italy; and Cardiology Division (Dr Myers), VA Palo Alto Health Care System, Stanford University, Palo Alto, California.
Simone
S
Uliari
Jonathan
J
Myers
Eva
E
Bernardi
Giorgio
G
Chiaranda
Francesco
F
Conconi
Francesco
F
Terranova
Gianni
G
Mazzoni
Giovanni
G
Grazzi
D000368:Aged; D003324:Coronary Artery Disease / Q000503:physiopathology*; D004562:Electrocardiography; D005080:Exercise Test; D017079:Exercise Tolerance; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D005082:Physical Exertion / Q000502:physiology*; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation