Interactions between bone cells and biomaterials: An update.
As the populations of the Western world become older, they will suffer more and more from bone defects related to osteoporosis (non-union fractures, vertebral damages), cancers (malignant osteolysis) and infections (osteomyelitis). Autografts are usually used to fill these defects, but they have several drawbacks such as morbidity at the donor site and the amount and quality of bone that can be harvested. Recent scientific milestones made in biomaterials development were shown to be promising to overcome these limitations. Cell interactions with biomaterials can be improved by adding at their surface functional groups such as adhesive peptides and/or growth factors. The development of such biomimetic materials able to control bone cell responses can only proceed if it is based on a sound understanding of bone cell behavior and regulation. This review focuses on bone physiology and the regulation of bone cell differentiation and function, and how the latest advances in biomimetic materials can be translated within promising clinical outcomes.
Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1.
Sabrina
S
Beauvais
Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1 and Ecole Polytechnique de Montreal, 2900, Blvd Edouard Montpetit, Montreal.
Olivier
O
Drevelle
Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1.
Jessica
J
Jann
Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1.
Marc-Antoine
MA
Lauzon
Universite de Sherbrooke, Carrefour d'Innovations en Technologies Ecologiques (CITE), 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1.
Mohammadreza
M
Foruzanmehr
Universite de Sherbrooke, Department of Surgery, 300112e Avenue N, Sherbrooke, Quebec, Canada, J1H 5N4 and Centre de Recherche du CHUS, 300112e Avenue N, Sherbrooke, Quebec, J1H 5N4.
Guillaume
G
Grenier
Centre de Recherche du CHUS, 300112e Avenue N, Sherbrooke, Quebec, J1H 5N4 and Universite de Sherbrooke, Department of Medicine, 300112e Avenue N, Sherbrooke, Quebec, Canada, J1H 5N4.
Sophie
S
Roux
Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1, and Centre de Recherche du CHUS, 300112e Avenue N, Sherbrooke, Quebec, J1H, Nathalie.Faucheux@Usherbrooke.ca.
Nathalie
N
Faucheux
D000367:Age Factors; D000368:Aged; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000494:pharmacology*; D001842:Bone and Bones / Q000166:cytology* / Q000187:drug effects*; D006801:Humans
D001672:Biocompatible Materials