Palladium catalysed meta-C-H functionalization reactions.
The directing group assisted site selective C-H functionalization approach is having a continuous impact in the field of natural product synthesis, drug discovery and material sciences. While ortho-selective C-H functionalization has been studied extensively, meta-selective C-H functionalization has been less explored. Recent studies have highlighted the efficacy of palladium as a catalyst in activating the meta-C-H bond of arenes. Notably, the introduction of a novel palladium catalysed directing template based approach to activate the remote meta-position has created a revolutionary impact towards seeking a solution to this long standing challenge. In this review we summarize recent advances in palladium catalysed meta-C-H functionalization that have helped in creating a new outlook towards modern organic synthesis.
Department of Chemistry, Indian Institute of Technology Bombay, India. dmaiti@iitb.ac.in.
Aniruddha
A
Dey
Soumitra
S
Agasti
Debabrata
D
Maiti
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D010165:Palladium; D002244:Carbon; D006859:Hydrogen