Elevation of serum heat-shock protein levels in amyotrophic lateral sclerosis.
Heat-shock proteins (HSPs) have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study, we aimed to examine whether the serum levels of HSPs (HSP27, HSP70, and HSP90) are altered in patients with ALS. We included 58 patients diagnosed with ALS and 85 control individuals. Serum HSP levels of patients and controls were determined using enzyme-linked immunosorbent assay. The serum levels of HSP70 and HSP90 were significantly higher in patients than in controls. In contrast, serum levels of HSP27 did not differ significantly between the patient and control groups. Moreover, serum levels of HSP70 and HSP90 in patients remained high throughout the duration of the disease. Taken together, our findings suggest that HSPs might have a role in ALS progression throughout the course of the disease. Further studies are needed to clarify the role of HSPs in the pathogenesis of ALS.
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.|Intractable Disease Care Center, Shinshu University Hospital, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Daigo
D
Miyazaki
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan. anakamu@shinshu-u.ac.jp.|Intractable Disease Care Center, Shinshu University Hospital, Asahi 3-1-1, Matsumoto, 390-8621, Japan. anakamu@shinshu-u.ac.jp.
Akinori
A
Nakamura
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Akiyo
A
Hineno
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Chinatsu
C
Kobayashi
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Tomomi
T
Kinoshita
Division of Neurogenetics, Department of Brain Disease Research, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Kunihiro
K
Yoshida
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Shu-Ichi
S
Ikeda
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D006360:Heat-Shock Proteins
Amyotrophic lateral sclerosis; Heat-shock protein 70; Heat-shock protein 90; Protein mis-folding; Serum heat-shock proteins