Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus.
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. mzivcec@cdc.gov.
Marko
M
Zivcec
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. kyj7@cdc.gov.
Florine E M
FE
Scholte
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. ccs8@cdc.gov.
Christina F
CF
Spiropoulou
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. wsk7@cdc.gov.
Jessica R
JR
Spengler
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. ebergeron@cdc.gov.
Éric
É
Bergeron
D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D023281:Genomics; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000235:genetics* / Q000502:physiology; D006479:Hemorrhagic Fever, Crimean / Q000635:transmission / Q000821:virology*; D006801:Humans; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D053586:Virus Internalization; D057074:Virus Release; D014779:Virus Replication
D014764:Viral Proteins
Crimean-Congo hemorrhagic fever; pathogenesis; reverse genetics; tick-borne virus; viral hemorrhagic fever