Junctional Adhesion Molecule-A in Head and Neck Squamous Cell Carcinoma.
Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is one of the tight junction molecules. JAM-A is dysregulated in various cancers and is closely associated with the invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer. In the present study, we found a high expression of JAM-A in head and neck squamous cell carcinoma (HNSCC) as well as β-catenin in immunohistochemistry. The expression of JAM-A and β-catenin was of a low level in differentiation-induced cancer pearl regions of HNSCC. Real-time PCR showed the high expression of JAM-A mRNA through all differentiated stages (well, moderate, poor) of HNSCC. When we performed ELISA using the serum of HNSCC patients to measure plasma-soluble JAM-A, it was found to be higher in HNSCC patients than healthy subjects. These results indicate that JAM-A is one of the malignancy markers of HNSCC as well as β-catenin in histopathology, and the plasma-soluble JAM-A may contribute to a serum diagnosis of HNSCC. JAM-A is a promising molecular target for diagnosis and therapy in HNSCC.
Makoto
M
Kurose
Takuya
T
Kakuki
Kenichi
K
Takano
Atsushi
A
Kondo
Kazufumi
K
Obata
Kazuaki
K
Nomura
Ryo
R
Miyata
Yakuto
Y
Kaneko
Takumi
T
Konno
Takayuki
T
Kohno
Takashi
T
Kojima
Tetsuo
T
Himi
D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D012334:RNA, Neoplasm / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000235:genetics*; D000077195:Squamous Cell Carcinoma of Head and Neck; D019108:Tight Junctions / Q000378:metabolism*
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C407243:F11R protein, human; D012334:RNA, Neoplasm; D011956:Receptors, Cell Surface