Effects of Laminaria japonica polysaccharides on exercise endurance and oxidative stress in forced swimming mouse model.
BACKGROUND
Polysaccharides are the major active ingredients responsible for the bioactivities of Laminaria japonica. However, the effects of L. japonica polysaccharides (LJP) on exercise endurance and oxidative stress have never been investigated. Therefore, this study was conducted to investigate the effects of LJP on exercise endurance and oxidative stress in a forced swimming mouse model. The animals were divided into four groups, namely the control (C), LJP-75, LJP-150, and LJP-300 groups, which received physiological saline and 75, 150, and 300 mg kg(-1) LJP, respectively, by gavage once a day for 28 days. This was followed by a forced swimming test and measurements of various biochemical parameters.


RESULTS
LJP increased swimming time to exhaustion, the liver and muscle glycogen content, and levels of superoxide dismutase, glutathione peroxidase, and catalase in the serum, liver, and muscle, which were accompanied by corresponding decreases in the malondialdehyde (MDA) content of the same tissues. Furthermore, decreases in blood lactic acid and serum myeloperoxidase (MPO) levels were observed.


CONCLUSIONS
LJP enhanced exercise endurance and protected mice against exhaustive exercise-induced oxidative stress.
Public PE Department, Zhejiang Shuren University, No. 8 Shuren Street, Hangzhou, 310015 Zhejiang Province People's Republic of China.
Feiwei
F
Yan
Department of Physical Education and Military Training, China Jiliang University, Hangzhou, 310018 China.
Haitao
H
Hao
Exercise endurance; Forced swimming test; Laminaria japonica polysaccharides; Mice; Oxidative stress