The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment.
Mitochondria play a critical role in regulating cellular functions, such as redox signaling, calcium homeostasis, and apoptosis. Also, mitochondria are crucial for neurogenesis and neuronal functions. Melatonin is an indole analog hormone, which is generally produced by the pineal gland. It plays a vital role in circadian rhythm and act as a powerful antioxidant by scavenging free radicals, immunomodulators, and anticancer agents. Schizophrenia and mood disorders are the two major psychiatric disorders. Disturbances of sleep and circadian rhythms are well-known symptoms of schizophrenia and mood disorders (bipolar disorder, major depression). Since melatonin has a regulator effect on circadian rhythm and sleep quality, it has a close interaction with schizophrenia and mood disorders. Herein, we aimed to summarize the effects of melatonin on mitochondrial activity in schizophrenia and mood disorders.
Department of Biophysics, School of Medicine Suleyman Demirel Universtiy, Isparta, Turkey. cihangiruguz@sdu.edu.tr.
Abdülhadi Cihangir
AC
Uguz
Kadir
K
Demirci
Javier
J
Espino
D000927:Anticonvulsants / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D008550:Melatonin / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D019964:Mood Disorders / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D017382:Reactive Oxygen Species; D008550:Melatonin