Monocyte to HDL Cholesterol Ratio Predicts Coronary Artery Disease Severity and Future Major Cardiovascular Adverse Events in Acute Coronary Syndrome.
BACKGROUND
We aimed to investigate the usefulness of monocyte to HDL cholesterol ratio (MHR) in predicting coronary artery disease severity and future major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS).


METHODS
2661 patient with ACS were enrolled and followed up during median 31.6 months.


RESULTS
MHR were significantly positively correlated with neutrophil to lymphocyte ratio (r=0.438), CRP (r=0.394), Gensini (r=0.407), and SYNTAX score (r=0.333). During in-hospital and long-term follow-up, MACE, stent thrombosis, non-fatal MI, and mortality occurred more frequently in the third tertile group. Kaplan-Meier analysis revealed the higher occurrence of MACE in the third tertile group compared with other tertiles. Adjusting for other factors, a MHR value in the third tertile group was determined as an independent predictor of in-hospital and long-term MACE.


CONCLUSIONS
MHR as a novel inflammation-based marker seemed to be an independent predictor of severity of coronary artery disease and future cardiovascular events in patients with ACS. MHR may utilise the identification of patients who are at higher risk for MACE and individualisation of targeted therapy.
Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
Mehmet Serkan
MS
Cetin
Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey. Electronic address: dr.elifhande@gmail.com.
Elif Hande
EH
Ozcan Cetin
Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
Erol
E
Kalender
Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
Selahattin
S
Aydin
Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
Serkan
S
Topaloglu
Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
Halil Lutfi
HL
Kisacik
Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
Ahmet
A
Temizhan
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D012720:Severity of Illness Index
D015415:Biomarkers; D008076:Cholesterol, HDL
Acute coronary syndrome; Gensini score; Inflammation; Monocyte to HDL ratio; SYNTAX score