In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring.
Depression is one of the most prevalent disorders in the world and may occur during pregnancy and postpartum periods. Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation. This study aimed to investigate if in utero and lactational exposure to FLX could compromise reproductive parameters in female offspring. Wistar rats received, by daily gavage, FLX 5mg/kg or 0.3ml of water (control group) from the first gestational day until weaning (21 days). Assessments in the female offspring included: body weight, anogenital distance, vaginal opening, first estrus, estrous cycle, reproductive organs weight, uterine morphometric analyses, ovarian follicle and corpora lutea counting, estradiol plasmatic concentration, sexual behavior, maternal behavior and fertility test. Exposure to FLX delayed the puberty onset in female pups. The present study demonstrated that developmental exposure to FLX can deregulate the neuroendocrine hormonal control of female offspring during prepubertal and pubertal periods.
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Alice Hartmann
AH
Dos Santos
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Milene Leivas
ML
Vieira
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Nathália
N
de Azevedo Camin
Department of Morphology, Estomatology and Physiology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Janete Aparecida
JA
Anselmo-Franci
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Graziela Scalianti
GS
Ceravolo
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Gislaine Garcia
GG
Pelosi
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Estefânia Gastaldello
EG
Moreira
Department of Physiology, São Paulo State University, Botucatu, São Paulo, Brazil.
Ana Carolina Inhasz
AC
Kiss
Department of Biology, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Suzana de Fátima Paccola
Sde F
Mesquita
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil. Electronic address: dcgerardin@uel.br.
Daniela Cristina Ceccatto
DC
Gerardin
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005473:Fluoxetine / Q000009:adverse effects*; D007774:Lactation; D008297:Male; D008425:Maternal Behavior / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012741:Sexual Maturation / Q000187:drug effects*; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
D018687:Antidepressive Agents, Second-Generation; D004958:Estradiol; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors
Female; Fertility; Fluoxetine; Maternal behavior; Puberty