The Relationship Between Reticular Macular Disease and Choroidal Thickness.
Subretinal drusenoid deposits (SDD) are the main structural lesion of reticular macular disease (RMD), a phenotype of age-related macular degeneration (AMD). We aim to demonstrate spatiotemporal relationships between SDD and choroidal thickness (CTh) alterations in RMD+ and RMD- eyes.



Thirty-three eyes (26 subjects) with early AMD/no SDD (RMD-) and 18 eyes (16 subjects) with early AMD/SDD (RMD+) underwent enhanced depth imaging spectral domain optical coherence tomography (SD-OCT) for CTh measurements at 11 points per scan, in 5 horizontal B scans, creating a grid of 55 points/eye. The 55 points were treated as a cluster, controlling within-subject correlation. Marginal generalized estimating equation modeling was used to estimate the association between CTh and RMD status. All eyes were divided by their median age (≤82 and >82 years) for stratified analyses.



CTh was not significantly reduced in RMD+ eyes compared with RMD- eyes (mean difference [MD] -16.84 μm, P = 0.24). Among younger subjects, mean CTh was significantly reduced in RMD+ versus RMD- eyes (MD -53.72 μm, P = 0.01). Conversely, among older subjects, there was no significant difference in CTh between RMD+ and RMD-.



In RMD, the association of SDD and CTh alterations varies with age but not by macular region. Among younger subjects (<82 years old), CTh was significantly thinner in RMD+ versus RMD- eyes.
a Department of Ophthalmology , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong , China.|b Department of Ophthalmology , New York University School of Medicine , New York , NY , USA.
Hao
H
Cheng
b Department of Ophthalmology , New York University School of Medicine , New York , NY , USA.
Patrick A
PA
Kaszubski
c Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Hua
H
Hao
b Department of Ophthalmology , New York University School of Medicine , New York , NY , USA.
Celine
C
Saade
b Department of Ophthalmology , New York University School of Medicine , New York , NY , USA.
Colleen
C
Cunningham
b Department of Ophthalmology , New York University School of Medicine , New York , NY , USA.|d Vitreous-Retina-Macula Consultants of New York , New York , NY , USA.
K Bailey
KB
Freund
b Department of Ophthalmology , New York University School of Medicine , New York , NY , USA.
R Theodore
RT
Smith
D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D008268:Macular Degeneration / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*
Age-related macular degeneration; choroidal thickness; reticular macular disease; subretinal drusenoid deposits