The Impacts of Serum Uric Acid on arterial hemodynamics and Cardiovascular Risks.
Hyperuricemia, and its clinical manifestation gout, is a metabolic disease process that has been recognized since the dawn of medical inquiry. Uric acid was hypothesized to be a mediator of cardiovascular disease for period of time. Epidemiological correlations of hyperuricemia with hypertension and cardiovascular events were evident for two centuries' studies. With recent animal studies shedding light on the causal mechanisms of hypertension, and clinical trials suggesting that urate-lowering therapy can lower blood pressure, there appears to be growing evidence of a connection between hyperuricemia and cardiovascular disease. To help bring this recent uric acid research into context, we have undertaken this narrative review of hyperuricemia, hypertension, its hemodynamics and its outcomes, and the risk for cardiovascular diseases.


BACKGROUND
Cardiovascular risk; Hemodynamics; Uric acid.
Healthcare and Management Center; ; Department of Cardiology; ; Institute of Public Health; ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.
Pai-Feng
PF
Hsu
National Health Research Institutes, Miaoli;
Shao-Yuan
SY
Chuang
Department of Cardiology;
Wen-Chung
WC
Yu
Healthcare and Management Center; ; Department of Cardiology;
Hsin-Bang
HB
Leu
Healthcare and Management Center; ; Department of Cardiology;
Wan-Leong
WL
Chan
Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei; ; Institute of Public Health; ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.
Chen-Huan
CH
Chen