A research roadmap for next-generation sequencing informatics.
Next-generation sequencing technologies are fueling a wave of new diagnostic tests. Progress on a key set of nine research challenge areas will help generate the knowledge required to advance effectively these diagnostics to the clinic.
Bioengineering, Genetics, and Medicine, Stanford University, Stanford, CA 94305, USA. russ.altman@stanford.edu.
Russ B
RB
Altman
Biomedical Data Science and Genetics, Stanford University, Stanford, CA 94305, USA.
Snehit
S
Prabhu
Pathology and Genetics, Stanford University, Stanford, CA 94305, USA.
Arend
A
Sidow
Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Material Measurement Laboratory, National Institute of Standards and Technology, Stanford University, Stanford, CA 94305, USA.
Justin M
JM
Zook
Biomedical Informatics, Stanford University, Stanford, CA 94305, USA.
Rachel
R
Goldfeder
Food and Drug Administration, Silver Spring, MD 20993, USA.
David
D
Litwack
Medicine, Genetics, and Pathology, Stanford University, Stanford, CA 94305, USA.
Euan
E
Ashley
DNAnexus, Mountain View, CA 94040, USA.
George
G
Asimenos
Biomedical Data Science and Genetics, Stanford University, Stanford, CA 94305, USA.
Carlos D
CD
Bustamante
Food and Drug Administration, Silver Spring, MD 20993, USA.
Katherine
K
Donigan
Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143, USA.
Kathleen M
KM
Giacomini
Food and Drug Administration, Silver Spring, MD 20993, USA.
Elaine
E
Johansen
Bioengineering, Stanford University, Stanford, CA 94305, USA.
Natalia
N
Khuri
Food and Drug Administration, Silver Spring, MD 20993, USA.
Eunice
E
Lee
Food and Drug Administration, Silver Spring, MD 20993, USA.
Xueying Sharon
XS
Liang
Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Bioengineering, Stanford University, Stanford, CA 94305, USA. Material Measurement Laboratory, National Institute of Standards and Technology, Stanford University, Stanford, CA 94305, USA.
Marc
M
Salit
DNAnexus, Mountain View, CA 94040, USA.
Omar
O
Serang
Food and Drug Administration, Silver Spring, MD 20993, USA.
Zivana
Z
Tezak
Systems Medicine and Psychiatry, Stanford University, Stanford, CA 94305, USA.
Dennis P
DP
Wall
Food and Drug Administration, Silver Spring, MD 20993, USA.
Elizabeth
E
Mansfield
Food and Drug Administration, Silver Spring, MD 20993, USA.
Taha
T
Kass-Hout
D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D048088:Informatics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D057285:Precision Medicine / Q000379:methods