Photochemical synthesis and anticancer activity of barbituric acid, thiobarbituric acid, thiosemicarbazide, and isoniazid linked to 2-phenyl indole derivatives.
2-Phenyl-1H-indole-3-carbaldehyde-based barbituric acid, thiobarbituric acid, thiosemicarbazide, isoniazid, and malononitrile derivatives were synthesized under photochemical conditions. The antitumor activities of the synthesized compounds were evaluated on three different human cancer cell lines representing prostate cancer cell line DU145, Dwivedi (DWD) cancer cell lines, and breast cancer cell line MCF7. All the screened compounds possessed moderate anticancer activity, and out of all the screened compounds, 5-{1[2-(4-chloro-phenyl)2-oxo-ethyl]-2-phenyl-1H-indole-3-ylmethylene}-2-thioxo-dihydro-pyrimidine-4,6-dione (2b) and 5-{1[2-(4-methoxy-phenyl)2-oxo-ethyl]-2-phenyl-1H-indole-3-ylmethylene}-2-thioxo-dihydro-pyrimidine-4,6-dione (2d) exhibited marked antitumor activity against used cell lines. Additionally, barbituric acid derivatives were selective to inhibit cell line DWD and breast cancer cell lines.
Department of Chemistry, Koneru Lakshmaiah University, Guntur, 522502 India.
S Vijaya
SV
Laxmi
Department of Chemistry, National Institute of Technology, Warangal, 506004 India.
G
G
Rajitha
Department of Chemistry, National Institute of Technology, Warangal, 506004 India.
B
B
Rajitha
Department of Zoology, Bhavan's College, Andheri (W), Mumbai, 400058 India.
Asha Jyothi
AJ
Rao
2-Phenyl-1H-indole-3-carbaldehyde; Anticancer activity; Photochemical condition; Thiobarbituric acid