An Update on Phytochemicals in Molecular Target Therapy of Cancer: Potential Inhibitory Effect on Telomerase Activity.
Telomerase is a ribonucleoprotein enzyme, which has a significant role in synthesizing DNA telomeric in eukaryotes. Telomere maintenance can cause to immortalization and malignant transformation of human cells and thereby telomerase activity must be scrutinized as an important factor in most tumor cells. The proliferation of cancer cells or apoptosis induction can be suppressed by telomerase inhibition using different therapeutic agents without any side effects upon normal cells. Natural substances, with anti-tumor effects, such as those derived from plants can be suitable candidates due to their capabilities in preventing some side effects and resistance of tumors with respect to most chemotherapeutic drugs. In this regards, many studies have shown that natural phytochemicals have inhibitory effects on telomerase activity through affecting its subunits and components. Therefore, the aim of this paper is to review the recent studies on these kinds of phytochemicals in terms of property and mechanism. Moreover, strategies for improving the therapeutic efficacy of plant-derived substances such as combination therapy and nanoformulation based approaches are included.
Abbas
A
Alibakhshi
Javad
J
Ranjbari
Yones
Y
Pilehvar-Soltanahmadi
Marzieh
M
Nasiri
Mahdie
M
Mollazade
Department of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nosratollah
N
Zarghami
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D003474:Curcumin / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D004339:Drug Compounding; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D064209:Phytochemicals / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D059808:Polyphenols / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D016588:Anticarcinogenic Agents; D064209:Phytochemicals; D059808:Polyphenols; D002392:Catechin; C045651:epigallocatechin gallate; D019098:Telomerase; D003474:Curcumin