Association Between Osteopontin Gene Polymorphisms and Cerebral Palsy in a Chinese Population.
Cerebral palsy (CP) is a neurological disorder affecting movement and posture that develops as a complication of prenatal, perinatal, and postnatal brain injury. Such non-progressive brain injury is often accompanied by neonatal encephalopathy and inflammation. The widely expressed soluble cytokine osteopontin (OPN) plays an important role in inflammation and neurological protection. Therefore, it is of great interest to study the relationship between CP and genetic variants of OPN. To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform. Statistical analysis was performed using the online SHEsis program, and Bonferroni correction was applied as necessary. We found an association between rs1126616 and global CP (corrected allelic P = 0.0006 and genotypic P = 0.0011 after Bonferroni correction). The other SNPs were not statistically associated with CP or any of its subgroups. By testing a relatively large sample size, our study demonstrates that the OPN gene SNP rs1126616 is statistically associated with CP. We suspect that the OPN gene might be a susceptibility factor for CP.
Zhengzhou Children's hospital, Zhengzhou, 450053, People's Republic of China.
Qing
Q
Shang
Zhengzhou Children's hospital, Zhengzhou, 450053, People's Republic of China.
Chongchen
C
Zhou
Zhengzhou Children's hospital, Zhengzhou, 450053, People's Republic of China.
Dongzhi
D
Liu
Zhengzhou Children's hospital, Zhengzhou, 450053, People's Republic of China.
Wenxia
W
Li
Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai, 200032, People's Republic of China.
Mingjie
M
Chen
Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Kangfuqian Street 7, Zhengzhou, 450052, People's Republic of China.
Yiran
Y
Xu
Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Kangfuqian Street 7, Zhengzhou, 450052, People's Republic of China.
Fei
F
Wang
Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Kangfuqian Street 7, Zhengzhou, 450052, People's Republic of China.
Dan
D
Bi
Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Kangfuqian Street 7, Zhengzhou, 450052, People's Republic of China.
Xiaoli
X
Zhang
Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai, 200032, People's Republic of China.
Xinzhi
X
Zhao
Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai, 200032, People's Republic of China.
Lei
L
Wang
Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Kangfuqian Street 7, Zhengzhou, 450052, People's Republic of China. zhuc@zzu.edu.cn.|Center for Brain Repair and Rehabilitation, University of Gothenburg, Gothenburg, Sweden. zhuc@zzu.edu.cn.
Changlian
C
Zhu
Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai, 200032, People's Republic of China. xingqinghe@hotmail.com.
Qinghe
Q
Xing
D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053495:Osteopontin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C506895:SPP1 protein, human; D053495:Osteopontin
Association; Cerebral palsy; Osteopontin; SNP