Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients.
OBJECTIVE
To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714).


METHODS
The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline.


RESULTS
Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723-0.951]). Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045-0.001]).


CONCLUSIONS
In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression.
Eli Lilly and Company, Windlesham, Surrey, UK.
Diego
D
Novick
Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia.
William
W
Montgomery
Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
Jaume
J
Aguado
Eli Lilly and Company, Indianapolis, IN, USA.
Xiaomei
X
Peng
Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
Josep Maria
JM
Haro
Asia; anxiety; depression; observational; outcomes