Rapid Infancy Weight Gain and 7- to 9-year Childhood Obesity Risk: A Prospective Cohort Study in Rural Western China.
Obesity is increasing in developing countries. This study aimed to identify the association between rapid infancy weight gain and obesity risk among early school-age children. A total of 581 singletons (349 boys, 232 girls) whose mothers participated in an antenatal multiple micronutrient supplement trial in rural western China were followed from birth to between 7 and 9 years of age. Height and weight were measured at birth, 1.5 years, and between 7 and 9 years. At the 7- to 9-year time point, body composition was determined using bioelectrical impedance analysis. Multilevel mixed analysis was used to test the associations between rapid weight gain in infancy (from birth to age 1.5 years) and body size and composition or overweight/obesity among early school-age children. Overall, 31.2% (181 of 581) of the infants showed a weight-for-age Z score gain greater than 0.67 between birth and 1.5 years, indicating rapid weight gain. Approximately 5.7% (33 of 579) of the subjects were overweight (BMI-for-age Z scores [BAZ] >1 and ≤2) or obese (BAZ >2). Rapid infancy weight gain was associated with a higher BAZ (P < 0.001), mid-upper arm circumferences (P < 0.001), percentage body fat (P < 0.001), and fat mass index (P < 0.001) at 7 to 9 years of age after adjusting for biological and social economic factors, genetic factors, and perinatal and postnatal factors. These associations appeared to be independent of gender, economic status at early school age, and maternal nutritional status at enrollment. Rapid growers may have approximately 3 times the risk of being overweight/obese during the early school-age years (odds ratio = 2.94, 95% CI: 1.17-7.43, P = 0.022). Rapid infancy weight gain is a risk factor for being overweight/obesity among early school-age children in rural western China. We propose that social and biological determinants, such as economic status, physical activity, and feeding practice, should be targeted to prevent obesity.
From the Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China (JZ, SD, LZ, QL, LP, CL, HY); Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, P.R. China (WG); Liverpool School of Tropical Medicine, University of Liverpool, Liverpool, UK (DW); Faculty of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China (WJ); and Nutrition and Food Safety Engineering Research Center of Shaanxi Province, Xi'an, Shaanxi, P.R. China (HY).
Jing
J
Zhou
Shaonong
S
Dang
Lingxia
L
Zeng
Wenlong
W
Gao
Duolao
D
Wang
Qiang
Q
Li
Wenhui
W
Jiang
Leilei
L
Pei
Chao
C
Li
Hong
H
Yan
D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004311:Double-Blind Method; D017097:Electric Impedance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage*; D063766:Pediatric Obesity / Q000178:diet therapy / Q000453:epidemiology / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012424:Rural Population; D015430:Weight Gain / Q000502:physiology*
D018977:Micronutrients