Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study.
The effect of naringenin, a flavonoid found in grapefruit, orange, and tomato, on lipid peroxidation and histopathological changes in the liver and kidneys of alloxan-induced diabetic mice were investigated. Two days after alloxan injection (75 mg kg-1, i.v.), naringenin ethanolic solution (0.5 % v/v) was given to mice intraperitoneally (50 mg kg-1 per day) for seven days. Naringenin's impact on lipid peroxidation was measured by the 2-thiobarbituric acid test and histopathological changes were examined under a light microscope. Naringenin administration resulted in a significant decrease of lipid peroxidation level in liver and kidney tissue, as well as in a decreased number of vacuolated liver cells and degree of vacuolisation. Indications of tissue repair in kidney suggested that amelioration of diabetes-induced renal damage could be achieved over a longer period of time. Findings suggest that naringenin could be considered a dietary supplement in the prevention or treatment of diabetic complications and other diseases connected with oxidative stress, and gives a hope that it could show similar effects in the treatment of diabetes in humans.
Damir
D
Sirovina
Nada
N
Oršolić
Gordana
G
Gregorović
Marijana Zovko
MZ
Končić
D000818:Animals; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics*; D048909:Diabetes Complications / Q000188:drug therapy / Q000209:etiology; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000473:pathology; D044950:Flavanones / Q000493:pharmacokinetics*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051379:Mice
D000897:Anti-Ulcer Agents; D044950:Flavanones; C005273:naringenin