An informatics research agenda to support precision medicine: seven key areas.
The recent announcement of the Precision Medicine Initiative by President Obama has brought precision medicine (PM) to the forefront for healthcare providers, researchers, regulators, innovators, and funders alike. As technologies continue to evolve and datasets grow in magnitude, a strong computational infrastructure will be essential to realize PM's vision of improved healthcare derived from personal data. In addition, informatics research and innovation affords a tremendous opportunity to drive the science underlying PM. The informatics community must lead the development of technologies and methodologies that will increase the discovery and application of biomedical knowledge through close collaboration between researchers, clinicians, and patients. This perspective highlights seven key areas that are in need of further informatics research and innovation to support the realization of PM.
Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA jessie.tenenbaum@duke.edu.
Jessica D
JD
Tenenbaum
Department of Biomedical Informatics, Harvard Medical School & Children's Hospital Informatics Program, Boston Children's Hospital, Boston, MA, USA.
Paul
P
Avillach
School of Nursing, University of Texas, Austin, TX, USA.
Marge
M
Benham-Hutchins
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Matthew K
MK
Breitenstein
Center for Bioinformatics & Computational Biology, University of Delaware, Newark, DE, USA.
Erin L
EL
Crowgey
Department of Biomedical & Health Informatics, University of Missouri - Kansas City, Children's Mercy Hospital, Kansas City, MO, USA.
Mark A
MA
Hoffman
Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Xia
X
Jiang
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Innovation Center for Biomedical Informatics, Washington, DC, USA.
Subha
S
Madhavan
Exponential Medicine, Singularity University; Internal Medicine, System Solutions at Kaiser Permanente, Pasadena, CA, USA.
John E
JE
Mattison
Division of Biomedical Informatics, University of Kentucky, Lexington, KY, USA.
Radhakrishnan
R
Nagarajan
Center for Health Informatics and Bioinformatics, New York University School of Medicine, New York, NY, USA.
Bisakha
B
Ray
Department of Pathology, MU Informatics Institute, University of Missouri, Columbia, MO, USA.
Dmitriy
D
Shin
Department of Biomedical Informatics and the Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, USA.
Shyam
S
Visweswaran
Center for Precision Health, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Zhongming
Z
Zhao
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Robert R
RR
Freimuth
D035843:Biomedical Research; D003219:Confidentiality / Q000592:standards; D057286:Electronic Health Records; D006801:Humans; D033181:Information Dissemination; D007258:Informed Consent; D008490:Medical Informatics; D057285:Precision Medicine / Q000379:methods / Q000592:standards
biomarkers; data sharing; informatics; precision medicine