Mammalian telomeres and their partnership with lamins.
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins. Multiple biochemical connections, including association of telomeres to the nuclear envelope and matrix, of telomeric proteins to lamins, and of lamin-associated proteins to chromosome ends, underline the interplay between lamins and telomeres. Paths toward senescence, such as defective telomere replication, altered heterochromatin organization, and impaired DNA repair, are common to lamins' and telomeres' dysfunction. The convergence of phenotypes can be interpreted through a model of dynamic, lamin-controlled functional platforms dedicated to the function of telomeres as fragile sites. The features of telomeropathies and laminopathies, and of animal models underline further overlapping aspects, including the alteration of stem cell compartments. We expect that future studies of basic biology and on aging will benefit from the analysis of this telomere-lamina interplay.
a Dipartimento di Biologia e Biotecnologie "C. Darwin," Sapienza Università di Roma , Rome, Italy.|b Istituto di Biologia e Patologia Molecolari del CNR , Rome , Italy.
Romina
R
Burla
a Dipartimento di Biologia e Biotecnologie "C. Darwin," Sapienza Università di Roma , Rome, Italy.
Mattia
M
La Torre
a Dipartimento di Biologia e Biotecnologie "C. Darwin," Sapienza Università di Roma , Rome, Italy.|b Istituto di Biologia e Patologia Molecolari del CNR , Rome , Italy.|c Istituto Pasteur Fondazione Cenci Bolognetti , Rome , Italy.
Isabella
I
Saggio
D000818:Animals; D004249:DNA Damage; D004261:DNA Replication; D004194:Disease / Q000235:genetics; D006801:Humans; D034882:Lamins / Q000378:metabolism*; D010641:Phenotype; D016615:Telomere / Q000235:genetics* / Q000378:metabolism*
D034882:Lamins
Progeria; aging; lamin; nuclear lamina; telomeres