In Vivo Apoptosis Imaging Using Site-Specifically (68)Ga-Labeled Annexin V.
Noninvasive molecular imaging, using positron emission tomography (PET), is an important technique to visualize metabolic processes in vivo. It also allows to visualize the process of apoptosis, by using radiolabeled compounds such as Annexin V, that bind to extracellular phosphatidylserine (PS). This chapter describes the radiosynthesis of (68)Ga-labeled Annexin V and how to noninvasively image apoptosis in vivo.
Nuclear Medicine, NUTRIM, Maastricht University Medical Center, P Debeyelaan 25, 6229 HX, Maastricht, Netherlands. Matthias.bauwens@mumc.nl.|Radiopharmacy, KU Leuven, Leuven, Belgium. Matthias.bauwens@mumc.nl.
Matthias
M
Bauwens
D000818:Animals; D017304:Annexin A5 / Q000378:metabolism*; D017209:Apoptosis; D002051:Burkitt Lymphoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005710:Gallium Radioisotopes / Q000378:metabolism*; D051379:Mice; D016513:Mice, SCID; D010718:Phosphatidylserines / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods*
D017304:Annexin A5; D005710:Gallium Radioisotopes; D010718:Phosphatidylserines
68Ga; Annexin V; Noninvasive imaging; PET