CYCLOPHOSPHAMIDE TREATMENT ALTERS THE CONTRACTILITY OF ISOLATED RAT VAS DEFERENS.
Influence of cyclophosphamide treatment (40. mg/kg, ip on alternate days for 5 times) was assessed on 1 m mol BaCl2-induced in vitro rhythmic contractions in isolated rat vas deferens. The mean frequency (contractions per min) and amplitude (g tension) of rhythmic contractions were significantly decreased in the tissues isolated from cyclophosphamide-treated rats as compared to the control tissues. These findings indicate a decrease in the contractility and, therefore, functioning of rat vas deferens under cyclophosphamide therapy.
Division of Pharmacology & Toxicology, Indian Veterinary Research Institute, Izatnagar (U.P) - 243 122.
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Reddy
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Raviprakash
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects* / Q000502:physiology
D003520:Cyclophosphamide; D002118:Calcium