Relationships between sleep quality and brain volume, metabolism, and amyloid deposition in late adulthood.
Recent studies in mouse models of Alzheimer's disease (AD) and in humans suggest that sleep disruption and amyloid-beta (Aβ) accumulation are interrelated, and may, thus, exacerbate each other. We investigated the association between self-reported sleep variables and neuroimaging data in 51 healthy older adults. Participants completed a questionnaire assessing sleep quality and quantity and underwent positron emission tomography scans using [18F]florbetapir and [18F]fluorodeoxyglucose and an magnetic resonance imaging scan to measure Aβ burden, hypometabolism, and atrophy, respectively. Longer sleep latency was associated with greater Aβ burden in prefrontal areas. Moreover, the number of nocturnal awakenings was negatively correlated with gray matter volume in the insular region. In asymptomatic middle-aged and older adults, lower self-reported sleep quality was associated with greater Aβ burden and lower volume in brain areas relevant in aging and AD, but not with glucose metabolism. These results highlight the potential relevance of preserving sleep quality in older adults and suggest that sleep may be a factor to screen for in individuals at risk for AD.
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; Neurology Department, Caen University Hospital, Caen, 14000, France.
Pierre
P
Branger
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Eider M
EM
Arenaza-Urquijo
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Clémence
C
Tomadesso
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Florence
F
Mézenge
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Claire
C
André
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Robin
R
de Flores
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Justine
J
Mutlu
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; Neurology Department, Caen University Hospital, Caen, 14000, France.
Vincent
V
de La Sayette
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Francis
F
Eustache
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France.
Gaël
G
Chételat
U1077, INSERM, GIP Cyceron, Caen, 14000, France; UMR-S1077, Ecole Pratique des Hautes Etudes, Caen, 14000, France; UMR-S1077, University of Caen Normandy, Caen, 14000, France; U1077, Caen University Hospital, Caen, 14000, France. Electronic address: rauchs@cyceron.fr.
Géraldine
G
Rauchs
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease / Q000209:etiology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008875:Middle Aged; D059906:Neuroimaging; D009929:Organ Size; D049268:Positron-Emission Tomography; D012306:Risk; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000378:metabolism* / Q000473:pathology*; D011795:Surveys and Questionnaires
D016229:Amyloid beta-Peptides
Alzheimer disease; Amyloid; Florbetapir; Neuroimaging; Sleep