Marrow Adipose Tissue: Trimming the Fat.
Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions for MAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and the development of bone metastases. The diversity of these functions highlights the breadth of the potential impact of MAT on health and disease.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University, Saint Louis, MO 63110, USA. Electronic address: scheller@wustl.edu.
Erica L
EL
Scheller
University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
William P
WP
Cawthorn
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Aaron A
AA
Burr
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06510, USA.
Mark C
MC
Horowitz
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: macdouga@umich.edu.
Ormond A
OA
MacDougald
D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000069796:Adipose Tissue, Beige / Q000378:metabolism; D000818:Animals; D000855:Anorexia / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000378:metabolism
adiponectin; adipose tissue; anorexia; beige fat; marrow fat; obesity