Kerion and Tinea Corporis Caused by Rabbit-Derived Trichophyton interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen.
Trichophyton interdigitale is generally deemed as an anamorph of Arthroderma vanbreuseghemii based on internal transcribed spacer (ITS) sequencing, but recently their anamorph/teleomorph connection should be cautioned based on β-tubulin phylogeny. We report three siblings and one consulting doctor who developed kerion and tinea corporis after contact with domestic rabbits. Seven same strains were isolated from four patients and three regions of a sick rabbit. The ITS and D1/D2 sequences of our isolate were 99 % homologous to A. Vanbreuseghemii, while β-tubulin sequence was 100 % identical to T. interdigitale. Our isolate was identified as T. interdigitale based on maximum likelihood analysis of β-tubulin. Random amplified polymorphic DNA revealed that the band patterns of five isolated strains and another rabbit-derived strain WCH023 were identical for OPF-03 and OPF-12. Skin lesions of all patients resolved completely for 2- to 6-week therapy of oral terbinafine and topical 1 % bifonazole or 1 % terbinafine cream. This study demonstrates that T. interdigitale of rabbit origin can cause various types of human dermatophytosis by mild scratch. Terbinafine may be the first choice for dermatophytosis caused by T. interdigitale.
Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.
Yan-Ping
YP
Yang
Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.
Ping
P
Sheng
Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.
Zhong
Z
Liu
Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.
Wen
W
Li
Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.
Jie-Di
JD
Wang
Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.
Wen-Ming
WM
Huang
Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China. ymfan1963@163.com.
Yi-Ming
YM
Fan
D054458:Amplified Fragment Length Polymorphism Analysis; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage; D002648:Child; D016000:Cluster Analysis; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000008:administration & dosage; D010802:Phylogeny; D010820:Physicians; D012335:RNA, Ribosomal / Q000235:genetics; D011817:Rabbits; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D035781:Siblings; D000077291:Terbinafine; D014005:Tinea / Q000175:diagnosis* / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome; D014249:Trichophyton / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014404:Tubulin / Q000235:genetics; D015047:Zoonoses / Q000175:diagnosis* / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology
D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D021903:DNA, Ribosomal Spacer; D007093:Imidazoles; D009281:Naphthalenes; D012335:RNA, Ribosomal; C065096:RNA, ribosomal, 26S; D014404:Tubulin; D000077291:Terbinafine; C036596:bifonazole
Arthroderma vanbreuseghemii; Kerion; Rabbit; Tinea corporis; Trichophyton interdigitale