Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors.
Malabaricones A-C (1-3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. yasodhasivasothy@gmail.com.
Yasodha
Y
Sivasothy
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. thibavengdes@yahoo.com.
Thiba
T
Krishnan
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. kokgan@um.edu.my.
Kok-Gan
KG
Chan
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. maryamabdwahab@gmail.com.
Siti Mariam
SM
Abdul Wahab
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. qmalxez44@gmail.com.
Muhamad Aqmal
MA
Othman
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, Cedex, France. marc.LITAUDON@cnrs.fr.
Marc
M
Litaudon
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. khalijah@um.edu.my.
Khalijah
K
Awang
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015374:Biosensing Techniques; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D026324:Myristicaceae / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000472:pathogenicity; D053038:Quorum Sensing / Q000187:drug effects*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D012118:Resorcinols; C000612644:giganteone A; C522672:malabaricone A
Myristica cinnamomea King; Myristicaceae; acylphenols; anti-quorum sensing activity; dimeric acylphenols