Fat eggs shape offspring health.
How maternal diet influences offspring metabolism is unclear, as it is difficult to distinguish between the effects of the in utero environment and epigenetic factors contributed by the oocyte. In a mouse model of high-fat diet, a new study teases apart these mechanisms by using in vitro fertilization and shows that susceptibility of offspring to metabolic disorder can likely be attributed to epigenetic inheritance via the oocyte.
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Erica D
ED
Watson
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Joanna
J
Rakoczy
D000818:Animals; D059305:Diet, High-Fat; D006801:Humans