Intra- and Intermolecular Nickel-Catalyzed Reductive Cross-Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides.
Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter- and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described.
Department of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Mikhail O
MO
Konev
Department of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Luke E
LE
Hanna
Department of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA. erjarvo@uci.edu.
Elizabeth R
ER
Jarvo
cross-coupling; cyclization; heterocycles; nickel; zinc