Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 - a rapid epidemiological and virological assessment.
In Denmark, both influenza A(H1N1)pdm09 and influenza B co-circulated in the 2015/16 season. We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine in patients 65 years and older using the test-negative case-control design. The adjusted VE against influenza A(H1N1)pdm09 was 35.0% (95% confidence interval (CI): 11.1-52.4) and against influenza B 4.1% (95% CI: -22.0 to 24.7). The majority of influenza A(H1N1)pdm09 circulating in 2015/16 belonged to the new genetic subgroup subclade 6B.1.
Department of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark.
Hanne Dorthe
HD
Emborg
Tyra Grove
TG
Krause
Lene
L
Nielsen
Marianne Kragh
MK
Thomsen
Claus Bohn
CB
Christiansen
Marianne Nielsine
MN
Skov
Xiaohui Chen
XC
Nielsen
Lenette Sandborg
LS
Weinreich
Thea Kølsen
TK
Fischer
Jesper
J
Rønn
Ramona
R
Trebbien
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008297:Male; D017063:Outcome Assessment, Health Care; D058873:Pandemics / Q000517:prevention & control*; D012621:Seasons; D018571:Sentinel Surveillance; D014611:Vaccination / Q000706:statistics & numerical data*; D064166:Vaccine Potency
D007252:Influenza Vaccines
antigenic characterization; genetic drift; phylogeny; seasonal influenza; vaccine effectiveness