Synthesis, antioxidant and analgesic activities of Schiff bases of 4-amino-1,2,4-triazole derivatives containing a pyrazole moiety.
A series of Schiff bases of 4-amino-1,2,4-triazole derivatives containing pyrazole (5a-h) were synthesized from condensation of 4-amino-5-(5-methyl-1H-pyrazol-3-yl)-4H-1,2,4-triazole-3-thiol (3) derivative with various aromatic aldehydes (4a-h). The structures of the synthesized compounds were elucidated by IR,1H NMR,13C NMR, and mass spectrometry. All the synthesized compounds (5a-h) were screened for their in vivo analgesic and in vitro antioxidant activities revealing significant analgesic and antioxidant properties.
Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco; LCAE, Department of Chemistry, Faculty of Sciences, University Mohamed I, Oujda, Morocco. Electronic address: Khalid.karrouchi@um5s.net.ma.
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K
Karrouchi
Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
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L
Chemlal
Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
J
J
Taoufik
Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
Y
Y
Cherrah
LCAE, Department of Chemistry, Faculty of Sciences, University Mohamed I, Oujda, Morocco.
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S
Radi
Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
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M
El Abbes Faouzi
Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
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M
Ansar
D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D005260:Female; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D010147:Pain Measurement / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D010851:Picrates; D011720:Pyrazoles; D012545:Schiff Bases; D014230:Triazoles; C045575:1,2,4-triazole; C004931:1,1-diphenyl-2-picrylhydrazyl
1,2,4-Triazole; Activité analgésique; Activité anti-oxydante; Analgesic activity; Antioxidant activity; Bases de Schiff; Pyrazole; Schiff bases