Steroid Induced Bilateral Avascular Necrosis of Head of Femur in an Adult Male Patient - A Case Report.
A 28 year old male patient, known case of pemphigus vulgaris was on dexamethasone pulse therapy. Total 7 pulses were given after that he developed avascular necrosis of head of femur on both sides, which was confirmed by digital X- ray and MRI. Avascular necrosis is a disabling and progressive condition in young patients gradually leads to femoral head collapse and eventual total hip arthroplasty. As per WHO-UMC causality assessment criteria, the association between reaction and drug was possible, Naranjo's score was 7. According to Modified Schumock and Thornton's criteria, this reaction was not preventable. The Modified Hartwig and Siegel's scale showed that the reaction was severe (level 6). Here we present a case where the use of steroid for pemphigus vulgaris resulting in the development of bilateral avascular necrosis of head of femur.
Department of Pharmacology, Govt. Medical College, Bhavnagar, Gujarat, India. dharamvir.jadeja@yahoo.com.
Dharamvirsinh
D
Jadeja
Vipul
V
Solanki
Bhavesh
B
Chavada
Chandrabhanu
C
Tripathi
D000328:Adult; D003907:Dexamethasone / Q000009:adverse effects*; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008297:Male
D005938:Glucocorticoids; D003907:Dexamethasone