CncRNAs: RNAs with both coding and non-coding roles in development.
RNAs are known to regulate diverse biological processes, either as protein-encoding molecules or as non-coding RNAs. However, a third class that comprises RNAs endowed with both protein coding and non-coding functions has recently emerged. Such bi-functional 'coding and non-coding RNAs' (cncRNAs) have been shown to play important roles in distinct developmental processes in plants and animals. Here, we discuss key examples of cncRNAs and review their roles, regulation and mechanisms of action during development.
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AJ, UK K.Sampath@warwick.ac.uk ephrussi@embl.de.
Karuna
http://orcid.org/0000-0002-0729-1977
K
Sampath
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, Heidelberg 69117, Germany K.Sampath@warwick.ac.uk ephrussi@embl.de.
Anne
http://orcid.org/0000-0002-5061-4620
A
Ephrussi
D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D006801:Humans; D012313:RNA; D022661:RNA, Untranslated
D022661:RNA, Untranslated; D012313:RNA
Bifunctional RNA; CncRNAs; Coding RNA; Development; Non-coding RNA; Regulatory RNA