Hyperostosis frontalis interna in postmenopausal women-Possible relation to osteoporosis.
To improve our understanding of hyperostosis frontalis interna (HFI), we investigated whether HFI was accompanied by changes in the postcranial skeleton. Based on head CT scan analyses, 103 postmenopausal women were divided into controls without HFI and those with HFI, in whom we measured the thickness of frontal, occipital, and parietal bones. Women in the study underwent dual energy x-ray absorptiometry to analyze the bone density of the hip and vertebral region and external geometry of the proximal femora. Additionally, all of the women completed a questionnaire about symptoms and conditions that could be related to HFI. Women with HFI had a significantly higher prevalence of headaches, neurological and psychiatric disorders, and a significantly lower prevalence of having given birth. Increased bone thickness and altered bone structure in women with HFI was localized only on the skull, particularly on the frontal bone, probably due to specific properties of its underlying dura. Bone loss in the postcranial skeleton showed the same pattern in postmenopausal women with HFI as in those without HFI. Recording of HFI in medical records can be helpful in distinguishing whether reported disorders occur as a consequence of HFI or are related to other diseases, but does not appear helpful in identifying women at risk of bone loss.
a Laboratory for Anthropology, Institute for Anatomy, School of Medicine , University of Belgrade , Belgrade , Serbia.
Danijela
D
Djonic
a Laboratory for Anthropology, Institute for Anatomy, School of Medicine , University of Belgrade , Belgrade , Serbia.|b Department of Radiology, School of Dental Medicine , University of Belgrade , Belgrade , Serbia.
Djurdja
D
Bracanovic
b Department of Radiology, School of Dental Medicine , University of Belgrade , Belgrade , Serbia.
Zoran
Z
Rakocevic
c Institute for Endocrinology, Diabetes and Metabolic Diseases , Clinical Center of Serbia , Belgrade , Serbia.
Miomira
M
Ivovic
d Institute of Forensic Medicine, School of Medicine , University of Belgrade , Belgrade , Serbia.
Slobodan
S
Nikolic
d Institute of Forensic Medicine, School of Medicine , University of Belgrade , Belgrade , Serbia.
Vladimir
V
Zivkovic
a Laboratory for Anthropology, Institute for Anatomy, School of Medicine , University of Belgrade , Belgrade , Serbia.
Marija
M
Djuric
D015502:Absorptiometry, Photon; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005624:Frontal Bone / Q000000981:diagnostic imaging*; D006801:Humans; D006957:Hyperostosis Frontalis Interna / Q000000981:diagnostic imaging*; D008875:Middle Aged; D017698:Postmenopause; D014057:Tomography, X-Ray Computed
Bone thickness; hyperostosis frontalis interna; osteoporosis; postmenopausal women