Na(+) Micro-Current Value Detection as a New Modality for Identification of Benign and Malignant Disease in Surgery.
Increase of intracellular positive ions (mainly Na(+)) indicates greater possibility of cell malignancy. The present study investigated the correlation between the Na(+) micro-current value (MCV) and tissue characteristics (normal, benign or malignant). 346 tissue samples have been detected within 30 min after surgical isolation by Na(+) detector. MCV in 102 malignant tumor was significantly higher than that in benign/borderline tumor or normal tissue (33.3 ± 8.9 μA vs. 24.4 ± 8.6 μA and 14.0 ± 4.0 μA, p < 0.001, respectively). MCV in malignant tumor parenchyma was significantly higher than that in the paired paracanceroustissue, normal tissue and surgical margin tissue (33.3 ± 8.9 μA vs. 18.9 ± 4.1, 14.2 ± 4.0 or 15.2 ± 3.3, p < 0.001, respectively). However, the coincidence rate between Na(+) detector and pathological examination was different in tissues from different organs or systems, which was high in pancreas, bile duct system, gastrointestinal system, esophagus, breasts, lungs, nose &throat and thyroids, but poor in urinary tissue. The overall coincidence rate was 83.1% (108/130) between Na(+) detector and pathological examination. The sensitivity and specificity of correct diagnosis by Na(+) detector was 83.3% (70/84) and 82.6% (38/46), respectively. This new modality may have diagnostic potential in complementing frozen examination in differentiating malignant tumor from benign or normal tissue, justifying tumor metastatic scope and confirming surgical margin.
Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center. Xi'an 710061, China.
Xu-Feng
XF
Zhang
Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center. Xi'an 710061, China.|Jingzhou Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jingzhou 434020, China.
Zhi-Da
ZD
Long
Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center. Xi'an 710061, China.
Xue-Min
XM
Liu
Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center. Xi'an 710061, China.
Feng
F
Ma
Jiangsu Kunshan Bokang Medical Technology Co. Ltd., Kunshan 215300,China.
Qiang
Q
Li
Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an 710061, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center. Xi'an 710061, China.
Yi
Y
Lv
D002412:Cations / Q000032:analysis*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D010340:Pathology, Surgical / Q000379:methods*; D012680:Sensitivity and Specificity; D012964:Sodium / Q000032:analysis*; D015222:Sodium Channels / Q000378:metabolism*
D002412:Cations; D015222:Sodium Channels; D012964:Sodium