The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain.
Although there were considerable advances in the anti-aging medical field, it is short of therapeutic drug for anti-aging. Mounting evidence indicates that the immunosenescence is the key physiopathological mechanism of aging. This study showed the treatment of LW-AFC, an herbal medicine, decreased the grading score of senescence, increased weight, prolonged average life span and ameliorated spatial memory impairment in 12- and 24-month-old senescence accelerated mouse resistant 1 (SAMR1) strain. And these anti-aging effects of LW-AFC were more excellent than melatonin. The administration of LW-AFC enhanced ConA- and LPS-induced splenocyte proliferation in aged SAMR1 mice. The treatment of LW-AFC not only reversed the decreased the proportions of helper T cells, suppressor T cells and B cells, the increased regulatory T cells in the peripheral blood of old SAMR1 mice, but also could modulate the abnormal secretion of IL-1β, IL-2, IL-6, IL-17, IL-23, GM-CSF, IFN-γ, TNF-α, TNF-β, RANTES, eotaxin, MCP-1, IL-4, IL-5, IL-10 and G-CSF. These data indicated that LW-AFC reversed the immunosenescence status by restoring immunodeficiency and decreasing chronic inflammation and suggested LW-AFC may be an effective anti-aging agent.
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Jianhui
J
Wang
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Xiaorui
X
Cheng
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Xiaorui
X
Zhang
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Junping
J
Cheng
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Yiran
Y
Xu
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Ju
J
Zeng
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Wenxia
W
Zhou
Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.|State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Yongxiang
Y
Zhang
D000375:Aging / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology / Q000517:prevention & control; D008136:Longevity / Q000187:drug effects* / Q000276:immunology; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology; D008569:Memory Disorders / Q000276:immunology / Q000517:prevention & control; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D025341:Principal Component Analysis
D000975:Antioxidants; D016207:Cytokines; D004365:Drugs, Chinese Herbal; C042579:Liuwei Dihuang Decoction; D008550:Melatonin
Gerotarget; LW-AFC; chronic inflammation; immunodeficiency; immunosenescence; senescence accelerated mouse resistant 1 (SAMR1) strain