The Role of the Renin-Angiotensin System in Amyloid Metabolism of Alzheimer's Disease.
The etiology of Alzheimer's disease (AD) remains unclear. Epidemiologic studies suggest hypertension plays a contributing role to AD. Recently, several experimental and observational studies showed interaction between the renin-angiotensin system and amyloid-β, a key pathologic feature of AD, with diverse results. This article reviews molecular, genetic, experimental and clinical data to clarify the impact on an AD patient with angiotensin converting enzyme inhibitor and angiotensin II receptor blocker therapy, with some guidance for the direction of possible future research.


BACKGROUND
Alzheimer's disease; Amyloid-β; Renin angiotensin system.
Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan; ; Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
Chao-Liang
CL
Chou
Section of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan; ; Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
Hung-I
HI
Yeh