The impact of compartmentalised housing on direct encephalomyocarditis virus (EMCV) transmission among pigs; insight from a model.
Although generally considered a rodent virus, pigs sometimes were suggested a potential reservoir host for encephalomyocarditis virus (EMCV), implying pig-to-pig transmission can cause major outbreaks in a pig population (basic reproduction ratio, R0>1). An earlier experimental study on EMCV transmission among pigs was inconclusive in this respect (R0≈1.24; CI 0.4-4.4). In this study we used a simulation model to extrapolate the experimental results to commercial, compartmentalised pig housings and tested to what extend contacts between pigs in different pens needed to be reduced in order to prevent major outbreaks in a compartment following a single introduction. The final size of simulated outbreaks was measured and the probability to observe outbreaks that affected at least 50 or 80% of the pens was calculated. Simulation scenarios compare one homogeneously mixing compartment (no fence) to epidemiological theory and an increasing effect of fencing on the pig-to-pig transmission between pigs in neighbouring pens. For any R0<1.24 the probability to observe outbreaks affecting more than 50% of the pens remained below 10% if compartmentalisation was introduced leaving per capita transmission rate unchanged. If fences also reduced contact transmission the probability to observe major outbreaks was below 50% for any R0<2.7. Only for R0>4, major outbreaks occurred with more than 50% chance even if only minimal contact between adjacent pens was allowed. In conclusion the results suggested that in a compartmentalised pig housing one single EMCV introduction is unlikely to cause a major outbreak by direct pig-to-pig transmission alone. Other mechanisms e.g. multiple introductions from a rodent reservoir may be required for large outbreaks to occur.
Netherlands Food and Consumer Product Safety Authority, The Netherlands.
Huibert
H
Maurice
Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany. Electronic address: hans.thulke@ufz.de.
Hans-Hermann
HH
Thulke
Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany; Leipzig University of Applied Sciences, Leipzig, Germany.
Julia Sabine
JS
Schmid
Utrecht University, The Netherlands.
Arjan
A
Stegeman
Utrecht University, The Netherlands.
Mirjam
M
Nielen
D000818:Animals; D018188:Cardiovirus Infections / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary*; D004686:Encephalomyocarditis virus / Q000502:physiology*; D006799:Housing, Animal; D008962:Models, Theoretical; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology
Compartmentalisation; Emcv; Encephalomyocarditis virus; Final size; Individual-based; Model alignment; Pigs; Rodent reservoir; Transmission model