Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study.
Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment.



We identified patients in the IntrePED registry with post-PED-treatment acute ischemic stroke. The rate of postoperative acute ischemic stroke was determined by demographics, comorbidities, aneurysm characteristics, and procedure characteristics (including anticoagulation use, platelet testing, number of devices used, sheaths, and so forth). Categoric variables were compared with χ(2) testing, and continuous variables were compared with the Student t test. Odds ratios and 95% confidence intervals were obtained by using univariate logistic regression. Multivariate logistic regression analysis was used to determine which factors were independently associated with postoperative stroke.



Of 793 patients with 906 aneurysms, 36 (4.5%) patients had acute ischemic stroke. Twenty-six (72.2%) strokes occurred within 30 days of treatment (median, 3.5 days; range, 0-397 days). Ten patients died, and the remaining 26 had major neurologic morbidity. Variables associated with higher odds of acute ischemic stroke on univariate analysis included male sex, hypertension, treatment of MCA aneurysms, treatment of fusiform aneurysms, treatment of giant aneurysms, and use of multiple PEDs. However, on multivariate analysis, the only one of these variables independently associated with stroke was treatment of fusiform aneurysms (OR, 2.74; 95% CI, 1.11-6.75; P = .03). Fusiform aneurysms that were associated with stroke were significantly larger than those not associated with stroke (mean, 24.5 ± 12.5 mm versus 13.6 ± 6.8 mm; P < .001).



Ischemic stroke following PED treatment is an uncommon-but-devastating complication. Fusiform aneurysms were the only variable independently associated with postoperative stroke.
From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.) brinjikji.waleed@mayo.edu.
W
0000-0001-5271-5524
W
Brinjikji
From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.) Neurosurgery (G.L., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota.
G
0000-0003-1479-465X
G
Lanzino
From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.) Neurosurgery (G.L., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota.
H J
0000-0003-2590-3815
HJ
Cloft
Department of Neurosurgery (A.H.S., D.F., E.L.), State University of New York, Buffalo, New York.
A H
0000-0002-9519-0059
AH
Siddiqui
Department of Neuroradiology (E.B.), Ospedale Niguarda-Ca' Granda, Milan, Italy.
E
0000-0002-5792-7187
E
Boccardi
Department of Radiology (S.C.), Hacettepe University Hospitals, Ankara, Turkey.
S
0000-0002-4521-2301
S
Cekirge
Department of Neurosurgery (A.H.S., D.F., E.L.), State University of New York, Buffalo, New York.
D
0000-0002-2677-8780
D
Fiorella
Department of Neurosurgery (R.H.), Baptist Neurological Institute, Jacksonville, Florida.
R
0000-0001-7195-5806
R
Hanel
Department Neurosurgery (P.J.), Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
P
0000-0002-8965-2413
P
Jabbour
Department of Neurosurgery (A.H.S., D.F., E.L.), State University of New York, Buffalo, New York.
E
0000-0002-6208-3724
E
Levy
Department of Neurosurgery (D.L.), Rush University Medical Center, Chicago, Illinois.
D
0000-0002-6280-0113
D
Lopes
Department of Interventional Neuroradiology (P.L.), Instituto Clínico ENERI, Buenos Aires, Argentina.
P
0000-0001-7044-4369
P
Lylyk
Department of Neuroradiology (I.S.), National Institute of Neurosciences, Budapest, Hungary.
I
0000-0003-3730-3278
I
Szikora
From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.) Neurosurgery (G.L., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota.
D F
0000-0002-8495-0040
DF
Kallmes
D000368:Aged; D004621:Embolization, Therapeutic / Q000009:adverse effects* / Q000295:instrumentation*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology*; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000209:etiology*