Metabolomics in Newborns.
Metabolomics is the quantitative analysis of a large number of low molecular weight metabolites that are intermediate or final products of all the metabolic pathways in a living organism. Any metabolic profiles detectable in a human biological fluid are caused by the interaction between gene expression and the environment. The metabolomics approach offers the possibility to identify variations in metabolite profile that can be used to discriminate disease. This is particularly important for neonatal and pediatric studies especially for severe ill patient diagnosis and early identification. This property is of a great clinical importance in view of the newer definitions of health and disease. This review emphasizes the workflow of a typical metabolomics study and summarizes the latest results obtained in neonatal studies with particular interest in prematurity, intrauterine growth retardation, inborn errors of metabolism, perinatal asphyxia, sepsis, necrotizing enterocolitis, kidney disease, bronchopulmonary dysplasia, and cardiac malformation and dysfunction.
University of Cagliari, Cagliari, Italy. Electronic address: antonionoto@hotmail.com.
Antonio
A
Noto
University of Cagliari, Cagliari, Italy.
Vassilios
V
Fanos
University of Cagliari, Cagliari, Italy.
Angelica
A
Dessì
D001237:Asphyxia / Q000097:blood / Q000175:diagnosis / Q000652:urine; D001997:Bronchopulmonary Dysplasia / Q000097:blood / Q000175:diagnosis / Q000652:urine; D020345:Enterocolitis, Necrotizing / Q000097:blood / Q000175:diagnosis / Q000652:urine; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D006330:Heart Defects, Congenital / Q000097:blood / Q000175:diagnosis / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000652:urine; D008661:Metabolism, Inborn Errors / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D055442:Metabolome; D055432:Metabolomics / Q000295:instrumentation / Q000379:methods*; D011247:Pregnancy; D018805:Sepsis / Q000097:blood / Q000175:diagnosis / Q000652:urine
(1)H NMR; GC/LC-MS; Metabolomics; Neonatal pathology; Newborn