Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides.
A green protocol has been applied to synthesize a novel series of 3-cyano-2-(tri-O-acetyl-β-D-arabinopyranosylthio)pyridines in a short reaction time, in higher yields and with simpler operations, when compared with the conventional heating method. Deacetylation of the obtained acetylated arabinosides produced 2-(β-D-arabinopyranosylthio)-3-cyanopyridines. The structures of the obtained products were confirmed on the basis of spectroscopic data (FT-IR, 1D, 2D-NMR). The synthesized compounds were screened for the antimicrobial activity against a selection of Gram positive and Gram negative bacteria.
Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia. t12im@yahoo.com.
Ibrahim A
IA
Maghrabi
Department of Microbiology, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia. alamh0@gmail.com.
Saleh
S
Alghamdi
Department of Microbiology, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia. majed.alrobaian@hotmail.co.uk.
Majed
M
Alrobaian
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia. Eldeab1@gmail.com.
Hany A
HA
Eldeab
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D055772:Green Chemistry Technology / Q000379:methods*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D000900:Anti-Bacterial Agents; D011725:Pyridines; D012997:Solvents
2(1H)-pyridinethione; antimicrobial; green synthesis; microwave; nucleosides; solvent-free conditions