Drug-induced lung injury associated with combination therapy of daclatasvir and asunaprevir: The first case report.
Combination therapy with direct acting antiviral agents (DAAs) without interferon (IFN) has emerged as a treatment for chronic hepatitis C because of its high overall sustained virologic response rates and favorable side effect profile as compared to that with interferon. We report the first case of drug-induced lung injury (DLI) associated with IFN-free therapy with the DAAs, daclatasvir (NS5A inhibitor) and asunaprevir (NS3/4A protease inhibitor). Although this combination therapy of DAAs has been considered to have fewer side effects than IFN, more attention should be paid to DLI as an important side effect.
Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Japan. Electronic address: takahiro00920619@gmail.com.
Takahiro
T
Kamada
Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Japan. Electronic address: k.furuta0113@gmail.com.
Kenjiro
K
Furuta
Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Japan. Electronic address: htomy@kobe-nishishimin-hospi.jp.
Hiromi
H
Tomioka
D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002219:Carbamates; D004359:Drug Therapy, Combination; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D007546:Isoquinolines / Q000008:administration & dosage / Q000009:adverse effects*; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D011759:Pyrrolidines; D013902:Radiography, Thoracic; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014633:Valine / Q000031:analogs & derivatives
D000998:Antiviral Agents; D002219:Carbamates; D007093:Imidazoles; D007546:Isoquinolines; D011759:Pyrrolidines; D013449:Sulfonamides; D011239:Prednisolone; D014633:Valine; C549273:daclatasvir; C571889:asunaprevir
Asunaprevir; Chronic hepatitis C; Daclatasvir; Direct acting antiviral agents; Drug-induced lung injury