Magnetic Resonance Imaging of Postoperative Fracture Healing Process without Metal Artifact: A Preliminary Report of a Novel Animal Model.
Background. Early radiological diagnosis and continual monitoring are of ultimate importance for timely treatment of delayed union, nonunion, and infection after bone fracture surgery. Although magnetic resonance imaging (MRI) could provide superior detailed images compared with X-ray and computed tomography (CT) without ionizing radiation, metal implants used for fracture fixation lead to abundant artifacts on MRI and thus prohibit accurate interpretation. The authors develop a novel intramedullary fixation model of rat femoral fracture using polyetheretherketone (PEEK) threaded rods and investigate its feasibility for in vivo MRI monitoring of the fracture healing process without artifact. Methods. Femoral fractures of 3 adult male Sprague-Dawley rats were fixed with intramedullary PEEK threaded rods. X-ray and MRI examinations were performed at day 7 postoperatively. Radiological images were analyzed for the existence of artifact interruption and postoperative changes in bone and peripheral soft tissue. Results. Postoperative plain film revealed no loss of reduction. MRI images illustrated the whole length of femur and peripheral tissue without artifact interruption, and the cortical bone, implanted PEEK rod, and soft tissue were clearly illustrated. Conclusion. This preliminary study introduced a novel rat model for in vivo MRI monitoring of the fracture healing process without metal artifact, by using intramedullary fixation of femur with PEEK threaded rod.
Department of Orthopaedics, First Hospital of China Medical University, 155 Nan Jing Bei Street, Heping District, Shenyang 110001, China.
Zhe
Z
Jin
Department of Radiological Diagnosis and Interventional Treatment, First Hospital of China Medical University, Shenyang 110001, China.
Yuheng
Y
Guan
Department of Radiological Diagnosis and Interventional Treatment, First Hospital of China Medical University, Shenyang 110001, China.
Guibo
G
Yu
Department of Orthopaedics, First Hospital of China Medical University, 155 Nan Jing Bei Street, Heping District, Shenyang 110001, China.
Yu
0000-0002-8330-942X
Y
Sun
D000818:Animals; D016477:Artifacts; D001577:Benzophenones; D001863:Bone Screws; D004195:Disease Models, Animal; D019544:Equipment Failure Analysis; D005264:Femoral Fractures / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D005593:Fracture Fixation, Internal / Q000295:instrumentation / Q000379:methods; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods; D007659:Ketones / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008670:Metals; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers; D011182:Postoperative Care / Q000295:instrumentation / Q000379:methods; D011474:Prosthesis Design; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D001577:Benzophenones; D007659:Ketones; D008670:Metals; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols