Recent refinements to cranial implants for rhesus macaques (Macaca mulatta).
The advent of cranial implants revolutionized primate neurophysiological research because they allow researchers to stably record neural activity from monkeys during active behavior. Cranial implants have improved over the years since their introduction, but chronic implants still increase the risk for medical complications including bacterial contamination and resultant infection, chronic inflammation, bone and tissue loss and complications related to the use of dental acrylic. These complications can lead to implant failure and early termination of study protocols. In an effort to reduce complications, we describe several refinements that have helped us improve cranial implants and the wellbeing of implanted primates.
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.|University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, PA.
Jessica M
JM
Johnston
Departments of Otorhinolaryngology-Head and Neck Surgery, Neuroscience, and Bioengineering, University of Pennsylvania, Philadelphia, PA.
Yale E
YE
Cohen
Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Harry
H
Shirley
Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Joji
J
Tsunada
Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Sharath
S
Bennur
Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA.
Kate
K
Christison-Lagay
University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, PA.
Christin L
CL
Veeder
D000180:Acrylic Resins / Q000009:adverse effects; D000818:Animals; D003399:Craniotomy / Q000009:adverse effects; D003738:Dental Cements / Q000009:adverse effects; D020007:Implants, Experimental / Q000009:adverse effects* / Q000382:microbiology; D008253:Macaca mulatta / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008992:Monkey Diseases / Q000382:microbiology / Q000517:prevention & control; D009482:Neurophysiology / Q000295:instrumentation / Q000379:methods; D011183:Postoperative Complications / Q000662:veterinary; D012886:Skull / Q000601:surgery*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D014945:Wound Healing
D000180:Acrylic Resins; D003738:Dental Cements