[ROLE OF SLC2A9 AND ABCG2 GENE POLYMORPHISMS IN ORIGIN OF HYPERURICEMIA AND GOUT].
The polymorphisms V253I, Q126X, Q141K of SLC2A9 and ABCG2 genes were characterized. GCA и GTC haplotypes of Q126X and Q141K variants can be predictors of gout. The relationship of these polymorphisms with hyperuricaemia according to gender, metabolic syndrome components, with the response to allopurinol was analyzed. It has been established that Q141K polymorphism can directly modulate BCRP-mediated allopurinol and oxypurinol efflux, the K allele is associated with a lower reduction in serum uric acid in response to allopurinol treatment.
Sumy State University, Medical institute, Internal Medicine Department Postgraduate Course, Sumy, Ukraine The article provides modern information about influence of the most common SLC2A9 and ABCG2 gene polymorphisms. These genes encode urate transporters (BCRP and GLUT9) that`s why associated with uric acid level and gout.
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Fadieieva
Sumy State University, Medical institute, Internal Medicine Department Postgraduate Course, Sumy, Ukraine The article provides modern information about influence of the most common SLC2A9 and ABCG2 gene polymorphisms. These genes encode urate transporters (BCRP and GLUT9) that`s why associated with uric acid level and gout.
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Prystupa
Sumy State University, Medical institute, Internal Medicine Department Postgraduate Course, Sumy, Ukraine The article provides modern information about influence of the most common SLC2A9 and ABCG2 gene polymorphisms. These genes encode urate transporters (BCRP and GLUT9) that`s why associated with uric acid level and gout.
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Pogorelova
Sumy State University, Medical institute, Internal Medicine Department Postgraduate Course, Sumy, Ukraine The article provides modern information about influence of the most common SLC2A9 and ABCG2 gene polymorphisms. These genes encode urate transporters (BCRP and GLUT9) that`s why associated with uric acid level and gout.
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Kirichenko
Sumy State University, Medical institute, Internal Medicine Department Postgraduate Course, Sumy, Ukraine The article provides modern information about influence of the most common SLC2A9 and ABCG2 gene polymorphisms. These genes encode urate transporters (BCRP and GLUT9) that`s why associated with uric acid level and gout.
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Dudchenko
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2 / Q000235:genetics*; D044466:Asian People; D044383:Black People; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics*; D006073:Gout / Q000235:genetics*; D006801:Humans; D033461:Hyperuricemia / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D051246:Glucose Transport Proteins, Facilitative; D009363:Neoplasm Proteins; C411811:SLC2A9 protein, human