Polyurethane/hydroxypropyl cellulose electrospun nanofiber mats as potential transdermal drug delivery system: characterization studies and in vitro assays.
Donepezil hydrochloride containing polyurethane/hydroxypropyl cellulose (PU/HPC) nanofibers were prepared by the electrospinning for transdermal drug delivery. PU/HPC nanofibers were characterized with SEM, DSC, and Pascal mercury porosimetry. Drug-excipient interaction was studied by ATR-FTIR. In vitro release of PU/HPC nanofiber mat (10:2:1) exhibited Korsmeyer-Peppas release kinetics controlled by the diffusion of drug. In vitro permeation studies across skin resembling synthetic membrane demonstrated the flux of model drug. The in vitro cytotoxicity data obtained via MTT assay indicated that PU/HPC nanofiber mat could be well tolerated by the skin and the components was not irritant for the skin.
a Department of Polymer Science and Technology , Istanbul Technical University , Istanbul , Turkey.
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Gencturk
b Department of Pharmaceutical Technology, Faculty of Pharmacy , Istanbul University , Istanbul , Turkey.
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Kahraman
b Department of Pharmaceutical Technology, Faculty of Pharmacy , Istanbul University , Istanbul , Turkey.
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Güngör
c Department of Toxicology, Faculty of Pharmacy , Istanbul University , Istanbul , Turkey.
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Özhan
b Department of Pharmaceutical Technology, Faculty of Pharmacy , Istanbul University , Istanbul , Turkey.
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Özsoy
a Department of Polymer Science and Technology , Istanbul Technical University , Istanbul , Turkey.|d Department of Chemistry , Istanbul Technical University , Istanbul , Turkey.
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Sarac
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D000077265:Donepezil; D004337:Drug Carriers; D004339:Drug Compounding; D065546:Drug Liberation; D055664:Electrochemical Techniques; D007189:Indans / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008567:Membranes, Artificial; D051379:Mice; D018716:Molecular Mimicry; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D018697:Nootropic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010539:Permeability; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011140:Polyurethanes / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000378:metabolism
D004337:Drug Carriers; D007189:Indans; D008567:Membranes, Artificial; D018697:Nootropic Agents; D010880:Piperidines; D011140:Polyurethanes; D000077265:Donepezil; D002482:Cellulose; C008079:hydroxypropylcellulose
Donepezil; drug delivery; hydroxypropyl cellulose; nanofiber; polyurethane