Use of raw Euphorbia tirucalli extract for inhibition of ascitic Ehrlich tumor.
OBJECTIVE
to evaluate the effect of the Euphorbia tirucalli hydroalcoholic extract (ETHE) on the development of Ehrlich Tumor, in its ascitic form.


METHODS
we intraperitoneally inoculated 15 Swiss mice with 10.44 x 107 cells of Ehrlich Tumor and divided them in two groups one day after: ETHE Group (eight mice), treated with a dosage of 125 mg/kg/day of EHTE for five days; and Control Group (seven mice), treated only with 0.9% isotonic saline solution over the same period. The treatment was done by gavage. Ten days after inoculation, four mice from each group were sacrificed for quantification of tumor cell number, ascitic fluid volume and bone marrow cell number. The remaining animals were maintained to evaluate survival.


RESULTS
The ascitic fluid volume and the tumor cell number were decreased in the ETHE group when compared with the control group, but with no statistical significance. On the other hand, survival was higher in the ETHE group, as well as the number of bone marrow cells.


CONCLUSIONS
Treatment with ETHE after inoculation of Ehrlich Tumor decreases its development and increases survival and the bone marrow cellularity, thus reducing the myelosuppression present in the Ehrlich Tumor bearing mice.
Universidade Federal do Maranhão, São Luís, MA, Brasil.
Orlando José Dos
OJ
Santos
Hospital Universitário Presidente Dutra, UFMA, São Luís, MA, Brasil.
Euler Nicolau
EN
Sauaia Filho
Universidade Federal do Maranhão, São Luís, MA, Brasil.
Flávia Raquel Fernandes do
FR
Nascimento
Hospital de Câncer de Barretos, Barretos, SP, Brasil.
Francisco Cardoso Silva
FC
Júnior
Universidade Federal do Maranhão, São Luís, MA, Brasil.
Eder Magalhães Silva
EM
Fialho
Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
Rayan Haquim Pinheiro
RH
Santos
Universidade Federal do Maranhão, São Luís, MA, Brasil.
Rennan Abud Pinheiro
RA
Santos
Universidade Federal do Maranhão, São Luís, MA, Brasil.
Izabel Cristina Portela Bogéa
IC
Serra
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000517:prevention & control*; D028481:Euphorbia; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*
D010936:Plant Extracts