New steroidal saponins from the rhizomes of Paris delavayi and their cytotoxicity.
Four new furostanol saponins, named padelaosides C-F (1-4), together with four known spirostanol saponins 5-8 were isolated from the rhizomes of Paris delavayi Franchet. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1-4 extended the diversity and complexity of this furostanol saponin family. The cytotoxicity of all the saponins was evaluated for their cytotoxicity against human glioblastoma U87MG and human hepatocellular carcinoma Hep-G2 cell lines. The known spirostanol saponins 7 and 8 exhibited notable cytotoxicity against the two tumor cell lines with IC50 values of 1.13 and 3.42μM, respectively, while the new furostanol saponins 3 and 4 showed moderate cytotoxicity with IC50 values of 15.28 to 16.98μM.
Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Yang
Y
Liu
College of Plant Protection, Northwest A&F University, Yangling 712100, PR China.
Xiangrong
X
Tian
Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
Dong
D
Hua
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Fourth Military Medical University, Xi'an, PR China.
Guang
G
Cheng
School of Nursing, Fourth Military Medical University, Xi'an 710032, PR China.
Kaixing
K
Wang
State Key Laboratory of Fluorine & Nitrogen Chemicals, Xi'an 710065, PR China; Xi'an Modern Chemistry Research Institute, Xi'an 710065, PR China.
Lihan
L
Zhang
Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China. Electronic address: tanghaifeng71@163.com.
Haifeng
H
Tang
State Key Laboratory of Fluorine & Nitrogen Chemicals, Xi'an 710065, PR China; Xi'an Modern Chemistry Research Institute, Xi'an 710065, PR China. Electronic address: wmc204@163.com.
Minchang
M
Wang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013261:Sterols
Cytotoxicity; Furostanol saponin; Liliaceae; Padelaoside; Paris delavayi; Spirostanol saponin