Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review.
Aspergillus fumigatus is an environmental filamentous fungus that also acts as an opportunistic pathogen able to cause a variety of symptoms, from an allergic response to a life-threatening disseminated fungal infection. The infectious agents are inhaled conidia whose first point of contact is most likely to be an airway epithelial cell (AEC). The interaction between epithelial cells and conidia is multifaceted and complex, and has implications for later steps in pathogenesis. Increasing evidence has demonstrated a key role for the airway epithelium in the response to respiratory pathogens, particularly at early stages of infection; therefore, elucidating the early stages of interaction of conidia with AECs is essential to understand the establishment of infection in cohorts of at-risk patients. Here, we present a comprehensive review of the early interactions between A. fumigatus and AECs, including bronchial and alveolar epithelial cells. We describe mechanisms of adhesion, internalization of conidia by AECs, the immune response of AECs, as well as the role of fungal virulence factors, and patterns of fungal gene expression characteristic of early infection. A clear understanding of the mechanisms involved in the early establishment of infection by A. fumigatus could point to novel targets for therapy and prophylaxis.
Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver BC, Canada.
Carys A
CA
Croft
Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver BC, Canada.
Luka
L
Culibrk
Department of Biological Sciences, Simon Fraser University, Burnaby BC, Canada.
Margo M
MM
Moore
Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, VancouverBC, Canada; Prevention of Organ Failure Centre of Excellence, VancouverBC, Canada; Department of Medicine, Division of Respiratory Medicine, University of British Columbia, VancouverBC, Canada.
Scott J
SJ
Tebbutt
Aspergillus fumigatus; airway epithelial cell; aspergillosis; conidia; host–pathogen interactions; immunity; virulence