Obesity is Associated With Early Total Hip Revision for Aseptic Loosening.
Obesity affects more than half a billion people worldwide, including one-third of men and women in the United States. Obesity is associated with higher postoperative complication rates after total hip arthroplasty (THA). It remains unknown whether obese patients progress to revision THA faster than nonobese patients.



A total of 257 consecutive primary THAs referred to an academic tertiary care center for revision THA were retrospectively stratified according to preoperative body mass index (BMI), reason for revision THA, and time from primary to revision THA.



When examining primary THAs referred for revision THA, increasing BMI adversely affected the mean time to revision THA. The percentage of primary THAs revised at 5 years was 25% for a BMI of 18-25, 38% for a BMI of 25-30, 56% for a BMI of 30-35, 73% for a BMI of 35-40, and 75% for a BMI of greater than 40 (P < .001). The percentage of primary THAs revised at 15 years was 70%, 82%, 87%, 94%, and 100%, respectively (P < .001). A significant increase in early revision THA for aseptic loosening/osteolysis in obese patients (56%, 23/41) when compared with the nonobese patients (12%, 10/83, P < .001, relative risk ratio = 4.7).



Preoperative BMI influences the time of failure of primary THAs referred to an academic tertiary care for revision THA as well as the mechanism of failure. Specifically, obesity increased in the relative risk of early revision THA due to aseptic loosening/osteolysis by 4.7 fold.
Department of Orthopaedic Surgery, Stanford University, Redwood City, California; Department of Orthopaedic Surgery, Sancheti Institute of Orthopaedics and Rehabilitation, Pune, Maharashtra, India.
Ali J
AJ
Electricwala
Department of Orthopaedic Surgery, Stanford University, Redwood City, California; Department of Orthopaedic Surgery, Siriraj Hospital, Bangkok, Thailand.
Rapeepat
R
Narkbunnam
Department of Orthopaedic Surgery, Stanford University, Redwood City, California.
James I
JI
Huddleston
Department of Orthopaedic Surgery, Stanford University, Redwood City, California.
William J
WJ
Maloney
Department of Orthopaedic Surgery, Stanford University, Redwood City, California.
Stuart B
SB
Goodman
Department of Orthopaedic Surgery, Stanford University, Redwood City, California.
Derek F
DF
Amanatullah
D000328:Adult; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015992:Body Mass Index; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D016017:Odds Ratio; D011183:Postoperative Complications / Q000209:etiology; D011475:Prosthesis Failure / Q000209:etiology*; D012086:Reoperation / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013997:Time Factors
aseptic loosening; complications; obesity; survival; total hip arthroplasty