Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications.
The rich chemical and structural versatility of transition metal complexes provides numerous novel paths to be pursued in the design of molecules that exert particular chemical or physicochemical effects that could operate over specific biological targets. However, the poor cell permeability of metallodrugs represents an important barrier for their therapeutic use. The conjugation between metal complexes and a functional peptide vector can be regarded as a versatile and potential strategy to improve their bioavailability and accumulation inside cells, and the site selectivity of their effect. This perspective lies in reviewing the recent advances in the design of metallopeptide conjugates for biomedical applications. Additionally, we highlight the studies where this approach has been directed towards the incorporation of redox active metal centers into living organisms for modulating the cellular redox balance, as a tool with application in anticancer therapy.
QBIS-CAT Research Group, Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, E-17071 Girona, Catalonia, Spain. miquel.costas@udg.edu xavi.ribas@udg.edu and LIPPSO, Departament de Química, Universitat de Girona, Campus Montilivi, E-17071 Girona, Catalonia, Spain. marta.planas@udg.edu lidia.feliu@udg.edu.
Marta
M
Soler
LIPPSO, Departament de Química, Universitat de Girona, Campus Montilivi, E-17071 Girona, Catalonia, Spain. marta.planas@udg.edu lidia.feliu@udg.edu.
Lidia
L
Feliu
LIPPSO, Departament de Química, Universitat de Girona, Campus Montilivi, E-17071 Girona, Catalonia, Spain. marta.planas@udg.edu lidia.feliu@udg.edu.
Marta
M
Planas
QBIS-CAT Research Group, Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, E-17071 Girona, Catalonia, Spain. miquel.costas@udg.edu xavi.ribas@udg.edu.
Xavi
X
Ribas
QBIS-CAT Research Group, Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, E-17071 Girona, Catalonia, Spain. miquel.costas@udg.edu xavi.ribas@udg.edu.
Miquel
M
Costas
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D010455:Peptides