The Impact of Diabetic Neuropathy on Balance and on the Risk of Falls in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.
Diabetic neuropathy (DN) is a prevalent complication of Type 2 Diabetes Mellitus (T2DM) with a major impact on the health of the affected patient. We hypothesized that mediated by the dysfunctionalities associated with DN's three major components: sensitive (lack of motion associated sensory), motor (impairments in movement coordination) and autonomic (the presence of postural hypotension), the presence of DN may impair the balance in the affected patients. Our study's main aim is to evaluate the possible association between the presence and severity of DN and both the balance impairment and the risk of falls in patients with T2DM.



In this cross-sectional study we enrolled, according to a consecutive-case population-based setting 198 patients with T2DM. The presence and severity of DN was evaluated using the Michigan Neuropathy Screening Instrument, a tool which allows both diagnosing and severity staging of DN. The balance impairment and the risk of falls were evaluated using four validated and standardized tools: Berg Balance Scale (BBS), Timed-up and Go test (TUG), Single Leg Stand test (SLS) and Fall Efficacy Scale (FES-I).



The presence of DN was associated with significant decreases in the BBS score (40.5 vs. 43.7 points; p<0.001) and SLS time (9.3 vs. 10.3 seconds; p = 0.003) respectively increases in TUG time (8.9 vs. 7.6 seconds; p = 0.002) and FES-I score (38 vs. 33 points; p = 0.034). The MNSI score was reverse and significantly correlated with both BBS score (Spearman's r = -0.479; p<0.001) and SLS time (Spearman's r = -0.169; p = 0.017). In the multivariate regression model, we observed that patient's age, DN severity and depression's symptoms acted as independent, significant predictors for the risk of falls in patients with T2DM.



The presence of DN in patients with DM is associated with impaired balance and with a consecutively increase in the risk of falls.
Department of Functional Sciences,"Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Bogdan
0000-0002-0993-6206
B
Timar
2nd Department of Internal Medicine,"Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Romulus
R
Timar
Department of Cardiology,"Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Laura
L
Gaiță
Department of Infectious Diseases,"Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Cristian
C
Oancea
Legal Department,"Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Codrina
C
Levai
Department of Functional Sciences,"Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Diana
D
Lungeanu
D000058:Accidental Falls; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D004856:Postural Balance / Q000502:physiology*; D012306:Risk