Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications.
Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile: prime requisites considered during the selection of any excipient in formulation development.



The unique properties and applications of PEG have been discussed at length in the existing literature. However, a proper guidance on selection of PEG grade to cater to one's purpose is lacking. This article provides preliminary guidelines to formulators on selection of appropriate PEG grade, typically based on its physico-chemical properties and role-based functional application in pharmaceuticals. It should be noted that the aim article is not to deep dive in each application area.



Guidance on PEG application and grade of choice is lacking in the available literature. The authors have discussed and provided guidance to formulators on the appropriate PEG grade selection for particular application based on the available in vitro and in vivo literature data. In this review a State-of-the-art use of PEG in therapeutic applications, its clinical status and commercial use is also summarized. Nevertheless, toxicities related to different PEG grades and related impurities are discussed in this review.
a Department of Bioscience and Bioengineering , Indian Institute of Technology , Mumbai , India.
Anisha A
AA
D'souza
b Department Pharmaceutics, Biopharmaceutics & NutriCosmetics , Freie Universität Berlin, Institute of Pharmacy , Kelchstr. 31, 12169 Berlin , Germany.
Ranjita
R
Shegokar
D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D011108:Polymers; D011092:Polyethylene Glycols
Polyethylene glycol (PEG); liposomes; nanoparticles; nanotoxicity; permeation enhancer; plasticizer; polymer; solubilizers; stealth effect; surface modification/decoration