Preparation and antibacterial properties of gelatin grafted with an epoxy silicone quaternary ammonium salt.
Gelatin (GE) was modified with epoxy silicone quaternary ammonium salt (EPSiQA) under alkaline conditions (pH 10-11). Silyl and quaternary ammonium groups were linked to gelatin skeleton simultaneously. It was illustrated by XRD and DSC that the short-range order of GE is destroyed and the glass transition temperature (Tg) of GE drops 10 °C after modification. The measured contact angles and surface free energy calculated by Owens-Wendt equation showed that the surface energy of modified gelatin EPSiQA-GE is mainly contributed by the dispersive component of non-polarity silicone groups, the hydrophobility of EPSiQA-GE increases with the increase of grafted silicone units in gelatin. The results of minimum inhibitory concentration indicated that EPSiQA-GE has bactericidal property against Gram-positive bacteria, Gram-negative bacteria and has no antibacterial effect on mold.
a College of Chemical Engineering and Materials Science , Tianjin University of Science and Technology , Tianjin , P.R. China.|b Shandong Provincial Key Laboratory of Fine Chemicals , Qilu University of Technology , Jinan , P.R. China.
Junying
J
Li
a College of Chemical Engineering and Materials Science , Tianjin University of Science and Technology , Tianjin , P.R. China.
Zuoliang
Z
Sha
b Shandong Provincial Key Laboratory of Fine Chemicals , Qilu University of Technology , Jinan , P.R. China.
Wenyu
W
Zhang
b Shandong Provincial Key Laboratory of Fine Chemicals , Qilu University of Technology , Jinan , P.R. China.
Furong
F
Tao
b Shandong Provincial Key Laboratory of Fine Chemicals , Qilu University of Technology , Jinan , P.R. China.
Pengfei
P
Yang
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D004853:Epoxy Resins / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005780:Gelatin / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis*; D012828:Silicones / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004853:Epoxy Resins; D000644:Quaternary Ammonium Compounds; D012828:Silicones; D005780:Gelatin
Gelatin; antibacterial; quaternary ammonium; silicone; surface free energy