Effect of Hevea brasiliensis latex sap gel on healing of acute skin wounds induced on the back of rats.
OBJECTIVE
to evaluate the effect of topical delivery of latex cream-gel in acute cutaneous wounds induced on the back of rats.


METHODS
we subjected sixteen rats to dermo-epidermal excision of a round dorsal skin flap, with 2.5cm diameter. We divided the animals into two groups: Latex Group: application of cream-gel-based latex throughout the wound bed on postoperative days zero, three, six and nine;


METHODS
no treatment on the wound. Photographs of the lesions were taken on the procedure day and on the 6th and 14th postoperative days, for analyzing the area and the larger diameter of the wound. We carried out euthanasia of all animals on the 14th postoperative day, when we resected he dorsal skin and the underlying muscle layer supporting the wound for histopathological study.


RESULTS
there was no statistically significant difference in the percentage of wound closure, in the histopathological findings or in the reduction of the area and of the largest diameter of the wounds among the groups studied on the 14th postoperative day.


CONCLUSIONS
according to the experimental conditions in which the study was conducted, latex cream-gel did not interfere in the healing of acute cutaneous wounds in rats.
Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil.
Maria Vitória Carmo
MV
Penhavel
Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil.
Victor Henrique
VH
Tavares
Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil.
Fabiana Pirani
FP
Carneiro
Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil.
João Batista de
JB
Sousa
D000287:Administration, Topical; D000818:Animals; D005782:Gels; D028482:Hevea; D007840:Latex / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects*
D005782:Gels; D007840:Latex