The insights of Let-7 miRNAs in oncogenesis and stem cell potency.
The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.
Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Xin
X
Sun
Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Jian
J
Liu
Department of Otorhinolaryngology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Chongwen
C
Xu
Georgia Regents University Cancer Center, Augusta, GA, USA.|Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Shou-Ching
SC
Tang
Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Hong
H
Ren
D063646:Carcinogenesis / Q000235:genetics* / Q000473:pathology; D055354:Exosomes / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology*
D035683:MicroRNAs
DNA methylation; Let-7 miRNAs; anti-cancer research; cancer stem cells; clinical application; non-coding RNAs; regulatory loops