Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum.
Seven filicinic acid-based meroterpenoids (1-7), possessing 6/6/11, 6/6/7/5, or 6/6/10 ring systems, were isolated from Hypericum japonicum. All of them have novel skeletons with the incorporation of sesquiterpenoid moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein-Barr virus, with EC50 values of 0.57 and 0.49 μM, respectively. Furthermore, compounds 2a and 4 were well accommodated to the binding pocket of 2GV9 predicted by the molecular docking.
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, P. R. China.|Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, P. R. China.
Linzhen
L
Hu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, P. R. China.
Yu
Y
Zhang
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, P. R. China.
Hucheng
H
Zhu
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, P. R. China.
Junjun
J
Liu
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, P. R. China.
Hua
H
Li
Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204, P. R. China.
Xiao-Nian
XN
Li
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, P. R. China.
Weiguang
W
Sun
Department of Pharmacy, Renmin Hospital of Wuhan University , Wuhan 430060, P. R. China.
Junfen
J
Zeng
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, P. R. China.
Yongbo
Y
Xue
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, P. R. China.
Yonghui
Y
Zhang
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D053138:Cyclohexenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D020902:Hypericum / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D062105:Molecular Docking Simulation; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000998:Antiviral Agents; D053138:Cyclohexenes; D013729:Terpenes; C000627729:filicinic acid