UK guideline for the use of HIV Post-Exposure Prophylaxis Following Sexual Exposure, 2015.
We present the updated British Association for Sexual Health and HIV guidelines for HIV post-exposure prophylaxis following sexual exposure (PEPSE). This document includes a review of the current data to support the use of PEPSE, considers how to calculate the risks of infection after a potential exposure, and provides recommendations on when PEPSE should and should not be considered. We also review which medications to use for PEPSE, provide a checklist for initial assessment, and make recommendations for monitoring individuals receiving PEPSE. Special scenarios, cost-effectiveness of PEPSE, and issues relating to service provision are also discussed. Throughout the document, the place of PEPSE within the broader context of other HIV prevention strategies is considered.
Brighton and Sussex University Hospital, UK fiona.cresswell@bsuh.nhs.uk.
Fiona
F
Cresswell
BASHH HIV Special Interest Group, UK.
Laura
L
Waters
National AIDS Trust, UK.
Eleanor
E
Briggs
Guy's and St Thomas' Hospital, UK.
Julie
J
Fox
Terrence Higgins Trust, UK.
Justin
J
Harbottle
Chelsea and Westminster Hospital, UK.
David
D
Hawkins
Society of Sexual Health Advisers, UK.
Martin
M
Murchie
Whittall Street Clinic, UK.
Keith
K
Radcliffe
HIV Pharmacy Association, UK.
Paul
P
Rafferty
University College London, UK.
Alison
A
Rodger
Brighton and Sussex University Hospital, UK.
Martin
M
Fisher
D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000191:economics; D003075:Coitus; D003362:Cost-Benefit Analysis; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D056990:Post-Exposure Prophylaxis / Q000191:economics; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D012307:Risk Factors; D012725:Sexual Behavior; D006113:United Kingdom
D019380:Anti-HIV Agents
AIDS; BASHH guidelines; HIV; HIV prevention; Post-exposure prophylaxis (PEP); antiretroviral therapy; sexual exposure