Novel Technologies for Isolated Lung Perfusion: Beyond Lung Transplant.
Isolated lung perfusion (ILP) has been examined and developed in lung transplantation and thoracic oncology research. In lung transplantation, ILP has been used to assess physiologic integrity of donor lungs after removal from the donor, and it has also been proposed as a method for active treatment and repair of injured unsuitable donor organs ex vivo. ILP is attractive as a concept to deliver high-dose chemotherapy to treat pulmonary metastatic disease, referred to as in vivo lung perfusion. This article focuses on the rationale, technical aspects, and experimental and clinical experience of in vivo lung perfusion. A perspective on the future application of these techniques is described.
Division of Thoracic Surgery, Department of Surgery, Toronto General Hospital, UHN, University of Toronto, 200 Elizabeth Street, 9N-969, Toronto, Ontario M5G 2C4, Canada. Electronic address: marcelo.cypel@uhn.ca.
Marcelo
M
Cypel
Division of Thoracic Surgery, Department of Surgery, Toronto General Hospital, UHN, University of Toronto, 200 Elizabeth Street, 9N-969, Toronto, Ontario M5G 2C4, Canada.
Shaf
S
Keshavjee
D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D016040:Lung Transplantation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods*
Ex vivo; High-dose chemotherapy; In vivo; Lung perfusion