Comparative In Vitro Efficacy of Doripenem and Imipenem Against Multi-Drug Resistant Pseudomonas aeruginosa.
OBJECTIVE
To compare the in vitro efficacy of doripenem and imipenem against multi-drug resistant (MDR) Pseudomonas aeruginosa from various clinical specimens.


METHODS
Descriptive cross-sectional study.


METHODS
Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi, from November 2012 to November 2013.


METHODS
MDR Pseudomonas aeruginosa isolates from various clinical samples were included in the study. Susceptibility of Pseudomonas aeruginosa against doripenem and imipenem was performed by E-test strip and agar dilution methods. The results were interpreted as recommended by Clinical Laboratory Standard Institute (CLSI) guidelines.


RESULTS
The maximum number of Pseudomonas aeruginosa were isolated from pure pus and pus swabs. In vitro efficacy of doripenem was found to be more effective as compared to imipenem against MDR Pseudomonas aeruginosa with both E-test strip and agar dilution methods. Overall, p-values of 0.014 and 0.037 were observed when susceptibility patterns of doripenem and imipenem were evaluated with E-test strip and agar dilution methods.


CONCLUSIONS
In vitro efficacy of doripenem was found to be better against MDR Pseudomonas aeruginosaas compared to imipenem when tested by both E-test and agar dilution methods.
Department of Microbiology, Foundation University Medical College, Rawalpindi.
Nadia
N
Wali
Department of Microbiology, Pakistan Navy (PN) Shifa Hospital, Karachi.
Irfan Ali
IA
Mirza
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D000077726:Doripenem; D018432:Drug Resistance, Multiple; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D015378:Imipenem; D000077726:Doripenem