Age-Adjusted Glycated Albumin at Diagnosis is more Correlated with the Product of Age and Plasma Glucose than Plasma Glucose Alone in Patients with Neonatal Diabetes Mellitus.
BACKGROUND
We previously showed that glycated albumin (GA) is a useful glycemic control indicator in patients with neonatal diabetes mellitus (NDM), and that age-adjusted GA (Aa-GA) can reflect more accurately glycemic control status. Here, we investigated whether the age at diagnosis influences Aa-GA at diagnosis of NDM.


METHODS
Eight patients with NDM whose GA was measured at diagnosis (age at diagnosis: 39 ± 18 days; GA: 31.3 ± 7.6%; Aa-GA: 47.1 ± 10.3%; plasma glucose: 525 ± 194 mg/dl) were included. Aa-GA was calculated as follows: Aa-GA = GA × 14.0/[1.77 × log-age (days) + 6.65]. Correlations of GA or Aa-GA at diagnosis with its logarithmically transformed age in days (log-age), plasma glucose, and their product were investigated.


RESULTS
GA at diagnosis was not significantly correlated with log-age or plasma glucose. On the other hand, Aa-GA at diagnosis was significantly positively correlated with plasma glucose (R = 0.75, P = 0.031) and was more strongly positively correlated with the product of plasma glucose and log-age (R = 0.82, P = 0.012) although it was not correlated with log-age.


CONCLUSIONS
Aa-GA at diagnosis is influenced by both age in days and plasma glucose. This finding is likely to show the aspect that age in days is almost equal to diabetes duration because glycemic control indicators including GA reflect the weighted mean of plasma glucose.
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
Akiko
A
Furuya
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan. shige5p@asahikawa-med.ac.jp.
Shigeru
S
Suzuki
Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan.
Miho
M
Oshima
Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan.
Satoshi
S
Amamiya
Department of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan.
Atsushi
A
Nakao
Department of Pediatrics, Kochi Medical School, Kochi, Japan.
Mariko
M
Araki
Department of Neonatology, Kameda Medical Center, Kamogawa, Japan.
Kayo
K
Mizutani
Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan.
Satoshi
S
Hayano
Department of Pediatrics, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Katsumi
K
Ushijima
Department of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Tottori, Japan.
Aya
A
Imamoto
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Nobuhiko
N
Nagano
Department of Pediatrics, Surugadai Nihon University Hospital, Tokyo, Japan.
Tatsuhiko
T
Urakami
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
Kumihiro
K
Matsuo
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
Yusuke
Y
Tanahashi
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
Hiroshi
H
Azuma
Department of Internal Medicine, Kawanishi City Hospital, Kawanishi, Japan.
Masafumi
M
Koga
D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood; D008297:Male; D012709:Serum Albumin / Q000378:metabolism*; D013223:Statistics as Topic; D000093423:Glycated Serum Albumin
D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
diabetes duration; glycated albumin; neonatal diabetes mellitus; plasma glucose