MEG Analysis of Neural Interactions in Attention-Deficit/Hyperactivity Disorder.
The aim of the present study was to explore the interchannel relationships of resting-state brain activity in patients with attention-deficit/hyperactivity disorder (ADHD), one of the most common mental disorders that develop in children. Magnetoencephalographic (MEG) signals were recorded using a 148-channel whole-head magnetometer in 13 patients with ADHD (range: 8-12 years) and 14 control subjects (range: 8-13 years). Three complementary measures (coherence, phase-locking value, and Euclidean distance) were calculated in the conventional MEG frequency bands: delta, theta, alpha, beta, and gamma. Our results showed that the interactions among MEG channels are higher for ADHD patients than for control subjects in all frequency bands. Statistically significant differences were observed for short-distance values within right-anterior and central regions, especially at delta, beta, and gamma-frequency bands (p < 0.05; Mann-Whitney U test with false discovery rate correction). These frequency bands also showed statistically significant differences in long-distance interactions, mainly among anterior and central regions, as well as among anterior, central, and other areas. These differences might reflect alterations during brain development in children with ADHD. Our results support the role of frontal abnormalities in ADHD pathophysiology, which may reflect a delay in cortical maturation in the frontal cortex.
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain.
Amine
A
Khadmaoui
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain.
Carlos
C
Gómez
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain; IMUVA, Instituto de Investigación en Matemáticas, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 7, 47011 Valladolid, Spain.
Jesús
J
Poza
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain.
Alejandro
A
Bachiller
Department of Psychiatry, Facultad de Medicina, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain; Laboratory of Cognitive and Computational Neuroscience, Centro de Tecnología Biomédica, Campus Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain.
Alberto
A
Fernández
Department of Psychiatry, Facultad de Medicina, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain; Psychiatry Service, Hospital Infanta Leonor, Avenida Gran Vía del Este 80, 28031 Madrid, Spain.
Javier
J
Quintero
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain; IMUVA, Instituto de Investigación en Matemáticas, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 7, 47011 Valladolid, Spain.
Roberto
R
Hornero
D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted