EFFECT OF 5-HT3 ANTAGONIST ONDANSETRON ON WRAP-RESTRAINT AND CONDITIONED EMOTIONAL STRESS INDUCED DEFECATION.
The effect of ondansetron was investigated in wrap-restraint and conditioned emotional (footshock) stress induced colonic hypermotility in rat. Ondansetron was administered in doses of 0.1, 0.5 and 1 mg/kg, sc. In wrap-restraint group, ondansetron dose-dependently reduced the fecal output to baseline levels (0.51 ± 0.20 gm/rat, 0.48 ± 0.38 gm/rat, 0.38 ± 0.16 gm/rat with 0.1, 0.5 and 1 mg/kg respectively). Diazepam, 5 mg/kg and atropine, 1 mg/kg also decreased the fecal output in this model. In footshock group, ordansetron did not affect the emotional stress induced increase in fecal pellet output. Diazepam and atropine however, decreased the fecal output in this model also.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012.
R S
RS
Karan
L
L
Saha
S S
SS
Handu
V K
VK
Bhargava
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003213:Conditioning, Psychological; D003672:Defecation / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D017294:Ondansetron / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000494:pharmacology*; D013315:Stress, Psychological / Q000503:physiopathology*
D058831:Serotonin 5-HT3 Receptor Antagonists; D017294:Ondansetron; D001285:Atropine; D003975:Diazepam