Fluorescent non-conjugated polymer dots for targeted cell imaging.
Through the chemical crosslinking of the sub-fluorophore, linear non-conjugated polymers can possess strong photoluminescence (PL), which is a very important fluorescence behavior and the non-conjugated polymer dots (PDs) are efficient bio-fluorophores for bio-based applications. Herein, the new type of non-conjugated polyethyleneimine (PEI) PDs was further modified by targeting molecules (folic acid) for a new generation of bio-fluorophores. The free folic acid can quench the PL of PDs by energy transfer, while the conjugated folic acid@PDs (FA@PDs) can still maintain their PL properties to a certain degree. The FA@PDs also possess lower toxicity compared with free PDs, which is possibly due to blocking of the amino groups. Moreover, we investigated the targeted bioimaging applications of the FA@PDs, which gave a very important direction for application of these types of materials.
Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun, 130041, P. R. China.
Bin
B
Sun
Bin
B
Zhao
Dandan
D
Wang
Yibo
Y
Wang
Qi
Q
Tang
Shoujun
S
Zhu
Bai
B
Yang
Hongchen
H
Sun
D045744:Cell Line, Tumor; D005456:Fluorescent Dyes; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D011094:Polyethyleneimine; D011108:Polymers
D005456:Fluorescent Dyes; D011108:Polymers; D011094:Polyethyleneimine; D005492:Folic Acid