An Overview of Tissue Engineering as an Alternative for Toxicity Assessment.
Tissue engineering is a multidisciplinary field that combines aspects of biology, material sciences, engineering and medicine - the ultimate goal being able to fabricate replacement tissues and/or organs for an ageing population. However, parallel to this milestone, is the exploitation of the biomimetic constructs as feasible alternatives to in vivo/ex vivo toxicity testing models due to their accurate representation of innate tissue and organs. Herein, we summarise a range of concepts within tissue engineering with a particular emphasis on biological material selection and implications to animal testing.
The Research Centre in Topical Drug Delivery and Toxicology, Department of Pharmacy, Pharmacology and Postgraduate Medicine, School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield, UK.. garrodm@hotmail.com.
Mathew
M
Garrod
David Yi San
DY
Chau
D000818:Animals; D006801:Humans; D023822:Tissue Engineering; D018675:Toxicity Tests / Q000379:methods*