[Impact of age-related cataract on regulation of circadian rhythm in elderly].
This review presented an introduction of the visual pathway related circadian rhythm regulation system: the intrinsically photosensitive retinal ganglion cells-suprachiasmatic nucleus-pineal gland-melatonin axis, and discussed the impact of light with different wave length and irradiation received by retina on circadian rhythm and sleep habit. A hypothesis was proposed consequently that the high morbidity of sleep disorder in elderly might be partially attributable to the long-term blue light blocking status induced by age-related cataract. A number of relative literatures were reviewed and a novel research direction was advanced on improving circadian rhythm and sleep condition in elderly based on the current knowledge. (Chin J Ophthalmol, 2016, 52: 309-314).
Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
M S
MS
Wang
M Y
MY
Liu
X R
XR
Dong
W
W
Wang
D000367:Age Factors; D000368:Aged; D002386:Cataract / Q000150:complications*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D008550:Melatonin / Q000378:metabolism; D010786:Photoreceptor Cells / Q000378:metabolism; D010870:Pineal Gland; D012165:Retinal Ganglion Cells / Q000378:metabolism*
D008550:Melatonin