The potential biochemical markers of Kashin-Beck disease: a meta-analysis.
OBJECTIVE
The objective of this study is to explore the cytokines in serum, synovial fluid as potential biomarkers of Kashin-Beck disease (KBD) and to further understand the role of these cytokines in the pathogenesis of KBD.


METHODS
A systematic electronic database search was performed from inception up to 15 March 2015. Meta-analysis was performed for cytokines more than one repetition in studies with available data. The effect size was summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) by a random effect model.


RESULTS
A total of 18 articles were included. The pooled standardized mean differences showed the serum levels of tumor necrosis factor alpha (2.72, 95% CI: 1.8 5-3.59), interleukin-1 beta (1.21, 95% CI: 0.6 1-1.80), and nitric oxide (2.60, 95% CI: 1.5 2-3.68) were significantly higher in adult KBD patients compared with that in healthy controls.


CONCLUSIONS
There was explicit evidence showing that the tumor necrosis factor alpha, interleukin-1 beta and nitric oxide were closely related to the presence of KBD, and these cytokines played a vital role in the pathogenesis of KBD.
a School of Public Health, Health Science Center , Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission , Xi'an , Shaanxi , People's Republic of China ;
Lei
L
Yang
a School of Public Health, Health Science Center , Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission , Xi'an , Shaanxi , People's Republic of China ;
Huan
H
Liu
a School of Public Health, Health Science Center , Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission , Xi'an , Shaanxi , People's Republic of China ;
Xiong
X
Guo
a School of Public Health, Health Science Center , Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission , Xi'an , Shaanxi , People's Republic of China ;|b Department of Integrative Medical Biology , University of Umeå , Umeå , Sweden.
Mikko Juhani
MJ
Lammi
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D006801:Humans; D057767:Kashin-Beck Disease / Q000097:blood* / Q000209:etiology; D013582:Synovial Fluid / Q000737:chemistry
D015415:Biomarkers; D016207:Cytokines
Biomarkers; Kashin–Beck disease; cytokines; meta-analysis