Single-eye trial of a topical carbonic anhydrase inhibitor versus intravitreal bevacizumab for the treatment of taxane drug-induced cystoid macula oedema.
Taxanes are a class of microtubule stabilising agents used to treat a wide range of malignancies. Taxane drug-induced cystoid macula oedema (TDICMO) is a known but rare complication of therapy. First reported with Docetaxel in 2003 and Paclitaxel in 2007, there are currently less than 20 cases of TDICMO in the literature. Although most cases resolve following taxane cessation, several authors have tried using carbonic anhydrase inhibitors or intravitreal bevacizumab to accelerate resolution or when taxane therapy cannot be discontinued. We report the first published case of TDICMO treated with a single-eye trial of topical dorzolamide versus intravitreal bevacizumab.
Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, UK.
Mark M
http://orcid.org/0000-0002-6180-7954
MM
Hassall
Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Nicholas Howard
NH
Andrew
D000287:Administration, Topical; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000068258:Bevacizumab / Q000008:administration & dosage*; D001952:Bridged-Ring Compounds / Q000009:adverse effects*; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D013449:Sulfonamides / Q000008:administration & dosage*; D043823:Taxoids / Q000009:adverse effects*; D013876:Thiophenes / Q000008:administration & dosage*
D020533:Angiogenesis Inhibitors; D001952:Bridged-Ring Compounds; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D043823:Taxoids; D013876:Thiophenes; C080625:taxane; D000068258:Bevacizumab; C062765:dorzolamide