De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited.
BACKGROUND
The pathogenesis of glioblastoma is complex, and the implicated molecular mechanisms are yet to be understood. There are scattered reports describing a possible relationship between meningioma and glioblastoma and more rarely a relationship between infarction and glioblastoma.


METHODS
We are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma. He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to both the territory of the prior MCA infarct and the residual meningioma.


CONCLUSIONS
This case adds further contribution to the literature of the possible pathological association between glioblastoma and brain infarction on a background of meningioma.
Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.
Waseem
W
Yaghmour
Department of Pathology, King Abdulaziz University, Jeddah, 21589, Kingdom of Saudi Arabia.
Maher E
ME
Kurdi
Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia. sbaeesa@kau.edu.sa.
Saleh S
SS
Baeesa
D000328:Adult; D005909:Glioblastoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000209:etiology / Q000473:pathology*; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications* / Q000601:surgery; D008579:Meningioma / Q000150:complications* / Q000601:surgery; D018365:Neoplasm, Residual / Q000209:etiology / Q000473:pathology*; D011379:Prognosis
Glioblastoma; Gliosis; Infarction; Meningioma; Pathogenesis