Low free triiodothyronine levels are related to symptomatic intracranial hemorrhage and poor functional outcomes after intravenous thrombolysis in acute ischemic stroke patients.
OBJECTIVE
Low free triiodothyronine (fT3) levels have been associated with increased mortality and poor functional outcomes in patients with stroke. However, the research of relationship between fT3 levels and acute ischemic stroke (AIS) patients with intravenous thrombolysis (IVT) is scarce. We aimed to investigate the association of fT3 levels with symptomatic intracranial hemorrhage (sICH) and functional outcomes at discharge in AIS patients with IVT.


METHODS
Patients with AIS admitted to West China hospital, Sichuan University, who had underwent IVT treatment, were consecutively and retrospectively included. Demographic and clinical information were collected and analyzed according to the levels of fT3. We used logistic regression analysis to estimate the multivariable adjusted association of fT3 levels and post-IVT sICH, and functional outcomes at discharge.


RESULTS
Among the 46 patients (26 males; mean age, 63.6 years) in the final analysis, 17 patients (37.0%) had fT3 levels lower than the reference range. After adjustment for age, gender, and statistically important variables (NIHSS on admission, urea levels and creatinine levels), low fT3 levels were significantly associated with post-IVT sICH (p = 0.01, OR = 0.27, 95% CI 0.10-0.77) and poor functional outcomes at discharge (p = 0.04 OR = 2.58, 95% CI 1.05-6.35).


CONCLUSIONS
We found that lower free T3 levels are independently related to post-IVT sICH and poor functional outcomes at discharge in AIS patients with IVT, which should be verified and extended in large cohorts in the future.
a Stroke Clinical Research Unit, Department of Neurology , West China Hospital, Sichuan University , Chengdu , P.R. China.
Junfeng
J
Liu
a Stroke Clinical Research Unit, Department of Neurology , West China Hospital, Sichuan University , Chengdu , P.R. China.
Deren
D
Wang
a Stroke Clinical Research Unit, Department of Neurology , West China Hospital, Sichuan University , Chengdu , P.R. China.
Yao
Y
Xiong
a Stroke Clinical Research Unit, Department of Neurology , West China Hospital, Sichuan University , Chengdu , P.R. China.
Ruozhen
R
Yuan
a Stroke Clinical Research Unit, Department of Neurology , West China Hospital, Sichuan University , Chengdu , P.R. China.
Wendan
W
Tao
a Stroke Clinical Research Unit, Department of Neurology , West China Hospital, Sichuan University , Chengdu , P.R. China.
Ming
M
Liu
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D020300:Intracranial Hemorrhages / Q000139:chemically induced*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology*; D014284:Triiodothyronine / Q000378:metabolism*
D005343:Fibrinolytic Agents; D014284:Triiodothyronine
Acute ischemic stroke; Intravenous thrombolysis; Symptomatic intracranial hemorrhage; Triiodothyronine