Bone mineral disorder in chronic kidney disease: Klotho and FGF23; cardiovascular implications.
Cardiovascular factors are one of the main causes of morbidity and mortality in patients with chronic kidney disease. Bone mineral metabolism disorders and inflammation are pathological conditions that involve increased cardiovascular risk in chronic kidney disease. The cardiovascular risk involvement of bone mineral metabolism classical biochemical parameters such as phosphorus, calcium, vitamin D and PTH is well known. The newest markers, FGF23 and klotho, could also be implicated in cardiovascular disease.
Servicio de Nefrología, Hospital de La Princesa, Madrid, España. Electronic address: aelita.sv@gmail.com.
Laura
L
Salanova Villanueva
Servicio de Nefrología, Hospital de La Princesa, Madrid, España.
Carmen
C
Sánchez González
Servicio de Nefrología, Hospital de La Princesa, Madrid, España.
José Antonio
JA
Sánchez Tomero
Servicio de Nefrología, Hospital de La Princesa, Madrid, España.
Abelardo
A
Aguilera
Servicio de Nefrología, Hospital de La Princesa, Madrid, España.
Esther
E
Ortega Junco
D000818:Animals; D015415:Biomarkers; D001842:Bone and Bones / Q000378:metabolism; D019703:Calcineurin / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005966:Glucuronidase / Q000502:physiology; D006801:Humans; D000090265:Klotho Proteins; D051379:Mice; D008903:Minerals / Q000378:metabolism; D008954:Models, Biological; D010281:Parathyroid Hormone / Q000502:physiology; D010758:Phosphorus / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism; D012307:Risk Factors; D061205:Vascular Calcification / Q000209:etiology / Q000517:prevention & control; D014807:Vitamin D / Q000378:metabolism
D015415:Biomarkers; C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D008903:Minerals; D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D019703:Calcineurin; D005966:Glucuronidase; D000090265:Klotho Proteins
Cardiovascular risk; Chronic kidney disease; Enfermedad renal crónica; FGF23; Klotho; Riesgo cardiovascular