Nanomaterial coatings applied on stent surfaces.
The advent of percutaneous coronary intervention and intravascular stents has revolutionized the field of interventional cardiology. Nonetheless, in-stent restenosis, inflammation and late-stent thrombosis are the major obstacles with currently available stents. In order to enhance the hemocompatibility of stents, advances in the field of nanotechnology allow novel designs of nanoparticles and biomaterials toward localized drug/gene carriers or stent scaffolds. The current review focuses on promising polymers used in the fabrication of newer generations of stents with a short synopsis on atherosclerosis and current commercialized stents, nanotechnology's impact on stent development and recent advancements in stent biomaterials is discussed in context.
Shariati Hospital, Mashhad University of Medical Sciences, Mashhad, PO Box 935189-9983, Iran.|Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, PO Box 91775-1365, Iran.
Mahsa
M
Bagheri
Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, PO Box 91775-1365, Iran.
Marzieh
M
Mohammadi
Division of Materials Technology, Materials & Science Engineering, Nanyang Technological University, Singapore.
Terry Wj
TW
Steele
Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, PO Box 91775-1365, Iran.
Mohammad
M
Ramezani
D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004247:DNA / Q000008:administration & dosage; D054855:Drug-Eluting Stents; D018014:Gene Transfer Techniques; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D011474:Prosthesis Design; D012313:RNA / Q000008:administration & dosage
D020099:Coated Materials, Biocompatible; D011108:Polymers; D012313:RNA; D004247:DNA
biosorbable stents; drug-eluting stent (DES); gene-eluting stent; medical implants; nanomaterials; nanotechnology; percutaneous coronary intervention (PCI); polymer