Short theta burst stimulation to left frontal cortex prior to encoding enhances subsequent recognition memory.
Deep semantic encoding of verbal stimuli can aid in later successful retrieval of those stimuli from long-term episodic memory. Evidence from numerous neuropsychological and neuroimaging experiments demonstrate regions in left prefrontal cortex, including left dorsolateral prefrontal cortex (DLPFC), are important for processes related to encoding. Here, we investigated the relationship between left DLPFC activity during encoding and successful subsequent memory with transcranial magnetic stimulation (TMS). In a pair of experiments using a 2-session within-subjects design, we stimulated either left DLPFC or a control region (Vertex) with a single 2-s train of short theta burst stimulation (sTBS) during a semantic encoding task and then gave participants a recognition memory test. We found that subsequent memory was enhanced on the day left DLPFC was stimulated, relative to the day Vertex was stimulated, and that DLPFC stimulation also increased participants' confidence in their decisions during the recognition task. We also explored the time course of how long the effects of sTBS persisted. Our data suggest 2 s of sTBS to left DLPFC is capable of enhancing subsequent memory for items encoded up to 15 s following stimulation. Collectively, these data demonstrate sTBS is capable of enhancing long-term memory and provide evidence that TBS protocols are a potentially powerful tool for modulating cognitive function.
Center for Cognitive Neuroscience, Duke University, Durham, USA. emd7@duke.edu.
Elise
E
Demeter
School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Jasmine L
JL
Mirdamadi
School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Sean K
SK
Meehan
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Stephan F
SF
Taylor
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003657:Decision Making / Q000502:physiology; D004569:Electroencephalography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology*; D012660:Semantics; D013826:Theta Rhythm / Q000502:physiology*; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D055815:Young Adult
Episodic memory; Prefrontal cortex; Recollection; TMS