Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015.
The first imported Middle East respiratory syndrome (MERS) case in China was identified in May 2015. We determined the kinetics of antibody (IgG and IgM) and neutralizing antibodies against MERS-coronavirus (MERS-CoV) in this case before discharge. Moreover, no seroconversion was found among 53 close contacts by anti-MERS IgG antibody enzyme-linked immunosorbent assay (ELISA) of paired serum samples. These findings suggest that neither community nor nosocomial transmission of MERS-CoV occurred in China.
Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Wen Ling
WL
Wang
Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Hui Juan
HJ
Wang
Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Yao
Y
Deng
Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.
Tie
T
Song
Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Jia Ming
JM
Lan
Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Gui Zhen
GZ
Wu
Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.
Chang Wen
CW
Ke
Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Wen Jie
WJ
Tan
D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D016358:Contact Tracing; D018352:Coronavirus Infections / Q000097:blood / Q000453:epidemiology* / Q000635:transmission*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D056910:Republic of Korea / Q000453:epidemiology; D014195:Travel
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M