THE ASSOCIATION BETWEEN CUTICULAR DRUSEN AND KIDNEY FUNCTION: A Population-Based Case-Control Study.
OBJECTIVE
To determine the association between cuticular drusen (CD) and kidney function.


METHODS
observational case-control study.


METHODS



METHODS
Population-based. Patients or Study Population: 53 participants with (CD) and 53 age- and sex-matched controls, selected from the Danish Rural Eye Study. Cuticular drusen participants were diagnosed using fluorescein angiography and controls were excluded if the patients were suspected of having CD on fundus photography or did not have an available estimated glomerular filtration rate.


METHODS
creatinine and estimated glomerular filtration rate.


RESULTS
The mean estimated glomerular filtration rate of those with CD was 73.3 mL·min·1.73 m (95% confidence interval [CI]: 70.0-76.6) and 73.4 mL·minute·1.73 m (95% CI: 69.5-77.3) in controls. The difference was not significant (P: 0.970). The mean creatinine among those with CD was 72.8 μmol/L (69.3-76.4) and 73.5 μmol/L (95% CI: 69.3-77.6) among controls. The difference was not significant (P = 0.820).


CONCLUSIONS
The authors did not find an association between a (CD) diagnosis and decreased kidney function at a population level.
*Department of Ophthalmology, Næstved Hospital, Næstved, Denmark;†The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;‡Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin;§Department of Ophthalmology, Capital Region Eye Clinic, Glostrup, Denmark; and¶Department of General Population Study, Nykøbing-Falster Hospital, Nykøbing Falster, Denmark.
Tracy B
TB
Høeg
Ronald
R
Klein
Birgitte
B
Moldow
Morten
M
La Cour
Kristian
K
Klemp
Ditte
D
Erngaard
Helena
H
Buch
Christina
C
Ellervik
D000368:Aged; D000369:Aged, 80 and over; D016570:Bruch Membrane / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D015785:Eye Diseases, Hereditary / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005451:Fluorescein Angiography; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015593:Retinal Drusen / Q000175:diagnosis / Q000503:physiopathology*
D003404:Creatinine