Reflectance confocal microscopy and dermoscopy forin vivo, non-invasive skin imaging of superficial basal cell carcinoma.
Superficial basal cell carcinoma (sBCC) is the second most frequent histological type of basal cell carcinoma (BCC), usually requiring a skin biopsy to confirm the diagnosis. It usually appears on the upper trunk and shoulders as erythematous and squamous lesions. Although it has a slow growth and seldom metastasizes, early diagnosis and management are of crucial importance in preventing local invasion and subsequent disfigurement. Dermoscopy is nowadays an indispensable tool for the dermatologist when evaluating skin tumors. Reflectance confocal microscopy (RCM) is a novel imaging technique that allows the non-invasive,in vivoquasi-microscopic morphological and dynamic assessment of superficial skin tumors. Moreover, it offers the advantage of performing infinite repeatable determinations to monitor disease progression and non-surgical treatment for sBCC. Herein, we present three lesions of sBCC evaluated usingin vivoand non-invasive imaging techniques, emphasizing the usefulness of combining RCM with dermoscopy for increasing the diagnostic accuracy of sBCC.
Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Mihaela A
MA
Ghita
Department of Physiology, 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania; Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest 011233, Romania.
Constantin
C
Caruntu
Department of Physiology, 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania; 'Victor Babes' National Institute of Pathology, Bucharest 050096, Romania.
Adrian E
AE
Rosca
Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest 011233, Romania.
Harillaq
H
Kaleshi
Department of Oral and Maxillofacial Surgery, 'Carol Davila' Central Military Emergency Hospital, Bucharest 010825, Romania.
Ana
A
Caruntu
Department of Oral and Maxillofacial Surgery, 'Carol Davila' Central Military Emergency Hospital, Bucharest 010825, Romania.
Liliana
L
Moraru
Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova 200349, Romania.
Anca Oana
AO
Docea
Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, Colentina University Hospital, Bucharest 020125, Romania.
Sabina
S
Zurac
Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Daniel
D
Boda
'Victor Babes' National Institute of Pathology, Bucharest 050096, Romania.
Monica
M
Neagu
Laboratory of Clinical Virology, University of Crete Medical School, Heraklion 71409, Greece.
Demetrios A
DA
Spandidos
Department of Forensic Sciences and Toxicology, Medical School, University of Crete, Heraklion 71003, Greece.
Aristidis M
AM
Tsatsakis
dermoscopy; in vivo skin imaging; non-invasive; reflectance confocal microscopy; superficial basal cell carcinoma