Urate Handling in the Human Body.
Elevated serum urate concentration is the primary cause of gout. Understanding the processes that affect serum urate concentration is important for understanding the etiology of gout and thereby understanding treatment. Urate handing in the human body is a complex system including three major processes: production, renal elimination, and intestinal elimination. A change in any one of these can affect both the steady-state serum urate concentration as well as other urate processes. The remarkable complexity underlying urate regulation and its maintenance at high levels in humans suggests that this molecule could potentially play an interesting role other than as a mere waste product to be eliminated as rapidly as possible.
Ardea Biosciences, Inc., Biology Department, 9390 Towne Centre Drive, San Diego, CA, 92121, USA. DHyndman@ardeabio.com.
David
D
Hyndman
Ardea Biosciences, Inc., Biology Department, 9390 Towne Centre Drive, San Diego, CA, 92121, USA.
Sha
S
Liu
Ardea Biosciences, Inc., Biology Department, 9390 Towne Centre Drive, San Diego, CA, 92121, USA.
Jeffrey N
JN
Miner
D006073:Gout / Q000378:metabolism; D006801:Humans; D033461:Hyperuricemia / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D027361:Organic Anion Transporters / Q000502:physiology; D065608:Renal Reabsorption / Q000502:physiology; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
D027361:Organic Anion Transporters; C103862:urate transporter; D014527:Uric Acid
Excretion; FEUA; Gout; Urate; Uric acid