Comparative Effectiveness of Carotid Artery Stenting Versus Carotid Endarterectomy Among Medicare Beneficiaries.
Effectiveness of carotid artery stenting (CAS) relative to carotid endarterectomy (CEA) among Medicare patients has not been established. We compared effectiveness of CAS versus CEA among Medicare beneficiaries.



We linked Medicare data (2000-2009) to the Society for Vascular Surgery's Vascular Registry (2005-2008) and the National Cardiovascular Data Registry's (NCDR) Carotid Artery Revascularization and Endarterectomy Registry (2006-2008/2009). Medicare patients were followed up from procedure date until death, stroke/transient ischemic attack, periprocedural myocardial infarction, or a composite end point for these outcomes. We derived high-dimensional propensity scores using registry and Medicare data to control for patient factors and adjusted for provider factors in a Cox regression model comparing CAS with CEA. Among 5254 Society for Vascular Surgery's Vascular Registry (1999 CAS; 3255 CEA) and 4055 Carotid Artery Revascularization and Endarterectomy Registry (2824 CAS; 1231 CEA) Medicare patients, CAS patients had a higher comorbidity burden and were more likely to be at high surgical risk (Society for Vascular Surgery's Vascular Registry: 96.7% versus 44.5%; Carotid Artery Revascularization and Endarterectomy Registry: 71.3% versus 44.7%). Unadjusted outcome risks were higher for CAS. Mortality risks remained elevated for CAS after adjusting for patient-level factors (hazard ratio, 1.24; 95% confidence interval, 1.06-1.46). After further adjustment for provider factors, differences between CAS and CEA were attenuated or no longer present (hazard ratio for mortality, 1.13; 95% confidence interval, 0.94-1.37). Performance was comparable across subgroups defined by sex and degree of carotid stenosis, but there was a nonsignificant trend suggesting a higher risk of adverse outcomes in older (>80) and symptomatic patients undergoing CAS.



Outcomes after CAS and CEA among Medicare beneficiaries were comparable after adjusting for both patient- and provider-level factors.
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Jessica J
JJ
Jalbert
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Louis L
LL
Nguyen
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Marie D
MD
Gerhard-Herman
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Hiraku
H
Kumamaru
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Chih-Ying
CY
Chen
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Lauren A
LA
Williams
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Jun
J
Liu
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Andrew T
AT
Rothman
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Michael R
MR
Jaff
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
John D
JD
Seeger
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
James F
JF
Benenati
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Peter A
PA
Schneider
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Herbert D
HD
Aronow
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Joseph A
JA
Johnston
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Thomas G
TG
Brott
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Thomas T
TT
Tsai
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.).
Christopher J
CJ
White
From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Baptist Cardiac and Vascular Institute, Miami, FL (J.F.B.); Department of Radiology, Florida International University School of Medicine, University Park (J.F.B.); Department of Vascular Therapy, Division of Vascular Surgery, Kaiser Foundation Hospital, Honolulu, HI (P.A.S.); Cardiac Catheterization Laboratory, St. Joseph Mercy Hospital, Ypsilanti, MI (H.D.A.); Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN (J.A.J.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Department of Cardiology, Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (T.T.T.); Department of Medicine, Division of Cardiovascular Medicine, University of Colorado Denver (T.T.T.); Department of Cardiovascular Diseases of the Ochsner Clinical School of the University of Queensland, Brisbane, Queensland, Australia (C.J.W.); Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA (C.J.W.); and Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.S.). soko@post.harvard.edu.
Soko
S
Setoguchi
D000368:Aged; D000369:Aged, 80 and over; D016893:Carotid Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D057186:Comparative Effectiveness Research; D016894:Endarterectomy, Carotid / Q000009:adverse effects / Q000401:mortality; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D005260:Female; D006801:Humans; D007342:Insurance Benefits; D002546:Ischemic Attack, Transient / Q000209:etiology; D053208:Kaplan-Meier Estimate; D008297:Male; D006278:Medicare; D009203:Myocardial Infarction / Q000209:etiology; D057216:Propensity Score; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D015607:Stents; D020521:Stroke / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
Medicare; carotid stenosis; comparative effectiveness research; endarterectomy, carotid; stents