Levels of the inflammation marker YKL-40 in young adults exposed to intrauterine hyperglycemia.
Plasma levels of the inflammatory marker YKL-40 were investigated in 597 adult offspring born to women with and without diabetes during pregnancy. No association between fetal exposure to maternal hyperglycemia and levels of YKL-40 was found. However, female sex and increasing BMI in the offspring were associated to YKL-40.
Center for Pregnant Women with Diabetes, Department of Obstetrics, 4031, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: louisekelstrup@dadlnet.dk.
Louise
L
Kelstrup
Center of Endocrinology and Metabolism, Department of Medicine, Copenhagen University Hospital Herlev, Herlev Ringvej 75, 2730 Herlev, Denmark; Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark. Electronic address: tfdejgaard@dadlnet.dk.
Thomas F
TF
Dejgaard
Center for Pregnant Women with Diabetes, Department of Obstetrics, 4031, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark; Department of Gynaecology and Obstetrics, Nordsjaellands Hospital Hilleroed, Dyrehavevej 29, 3400 Hilleroed, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark. Electronic address: tine.dalsgaard.clausen@dadlnet.dk.
Tine D
TD
Clausen
Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark; Center for Pregnant Women with Diabetes, Department of Endocrinology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: elisabeth.mathiesen@rh.regionh.dk.
Elisabeth R
ER
Mathiesen
The Novo Nordisk Foundation Center of Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, Universitetsparken 1, 1st floor, DIKU, 2100 Copenhagen Ø, Denmark; Faculty of Health Sciences, University of Southern Denmark, Faculty of Health Sciences, University of Southern Denmark, J.B. Winsløws Vej 19, 3, 5000 Odense C, Denmark. Electronic address: torben.hansen@sund.ku.dk.
Torben
T
Hansen
Center of Endocrinology and Metabolism, Department of Medicine, Copenhagen University Hospital Herlev, Herlev Ringvej 75, 2730 Herlev, Denmark; The Novo Nordisk Foundation Center of Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, Universitetsparken 1, 1st floor, DIKU, 2100 Copenhagen Ø, Denmark. Electronic address: henrik.vestergaard@sund.ku.dk.
Henrik
H
Vestergaard
Center for Pregnant Women with Diabetes, Department of Obstetrics, 4031, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark. Electronic address: pdamm@dadlnet.dk.
Peter
P
Damm
D000328:Adult; D032721:Adult Children; D015415:Biomarkers / Q000097:blood*; D000071451:Chitinase-3-Like Protein 1 / Q000097:blood*; D003718:Denmark / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D007249:Inflammation / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1
Inflammatory markers; Intrauterine hyperglycemia; Intrauterine programming; Long term consequences; YKL-40