A fast chemical exchange saturation transfer imaging scheme based on single-shot spatiotemporal encoding.
To design a new approach that can not only keep the spatial and temporal resolution but also have better built-in immunity to magnetic field inhomogeneity and chemical shift effects than the single-shot echo planar imaging (EPI) for chemical exchange saturation transfer (CEST) MRI.



The single-shot spatiotemporally encoded (SPEN) MRI sequence was combined with a continuous wave saturation pulse for fast CEST MRI (CEST-SPEN MRI). The resulting images were super-resolved reconstructed by a hybrid method that solves the l1norm minimization together with total variation (TV) regularization. Partial Lorentzian fitting was used to analyze the subsequent Z-spectra.



Experimental results of a creatine phantom and in vivo tumor rat brains show that CEST-SPEN MRI has good capability in providing CEST-based and NOE-based contrast images.



Compared with CEST-EPI, CEST-SPEN MRI has better immunity to magnetic field inhomogeneity and provides better contrast images within identical acquisition time, especially under an identical inhomogeneous field. Magn Reson Med 77:1786-1796, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China.
Jianpan
J
Huang
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China.
Miao
M
Zhang
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China.|Meizhouwan Vocational Technology College, Putian, China.
Jianhua
J
Lu
Department of Communication Engineering, Xiamen University, Xiamen, China.
Congbo
C
Cai
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China.
Lin
L
Chen
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China.
Shuhui
S
Cai
D000465:Algorithms; D000818:Animals; D016477:Artifacts; D001921:Brain / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000737:chemistry; D017352:Echo-Planar Imaging / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D051381:Rats; D059629:Signal-To-Noise Ratio; D013997:Time Factors
D003287:Contrast Media
chemical exchange saturation transfer; inhomogeneous field; magnetic resonance imaging; nuclear Overhauser enhancement; spatiotemporal encoding