Supramolecular 1-D polymerization of DNA origami through a dynamic process at the 2-dimensionally confined air-water interface.
In this study, a Langmuir-Blodgett (LB) system has been utilized for the regulation of polymerization of a DNA origami structure at the air-water interface as a two-dimensionally confined medium, which enables dynamic condensation of DNA origami units through variation of the film area at the macroscopic level (ca. 10-100 cm(2)). DNA origami sheets were conjugated with a cationic lipid (dioctadecyldimethylammonium bromide, 2C18N(+)) by electrostatic interaction and the corresponding LB-film was prepared. By applying dynamic pressure variation through compression-expansion processes, the lipid-modified DNA origami sheets underwent anisotropic polymerization forming a one-dimensionally assembled belt-shaped structure of a high aspect ratio although the thickness of the polymerized DNA origami was maintained at the unimolecular level. This approach opens up a new field of mechanical induction of the self-assembly of DNA origami structures.
World Premier International (WPI) Research Centre for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS) 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. ARIGA.Katsuhiko@nims.go.jp.
Yusuke
Y
Yonamine
Keitel
K
Cervantes-Salguero
Kosuke
K
Minami
Ibuki
I
Kawamata
Waka
W
Nakanishi
Jonathan P
JP
Hill
Satoshi
S
Murata
Katsuhiko
K
Ariga
D016880:Anisotropy; D004247:DNA / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D009690:Nucleic Acid Conformation; D058105:Polymerization; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D055672:Static Electricity; D014867:Water / Q000737:chemistry
D000644:Quaternary Ammonium Compounds; D014867:Water; C015831:dimethyldioctadecylammonium; D004247:DNA