Synthesis, characterization and fluorescent properties of water-soluble glycopolymer bearing curcumin pendant residues.
Curcumin is a potential natural anticancer drug with low oral bioavailability because of poor water solubility. The aqueous solubility of curcumin is enhanced by means of modification with the carbohydrate units. Polymerization of the curcumin-containing monomer with carbohydrate-containing monomer gives the water-soluble glycopolymer bearing curcumin pendant residues. The obtained copolymers (P1 and P2) having desirable water solubility were well-characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), UV-Vis absorption spectroscopy, and photoluminescence spectroscopy. The copolymer P2 with a molar ratio of 1:6 (curcumin/carbohydrate) calculated from the proton NMR results exhibits a similar anticancer activity compared to original curcumin, which may serve as a potential chemotherapeutic agent in the field of anticancer medicine.
a College of Chemistry and Environmental Science, Hebei University , Baoding , P.R. China.|b Department of Nephrology , Affiliated Hospital of Hebei University , Baoding , P.R. China.
Haisong
H
Zhang
b Department of Nephrology , Affiliated Hospital of Hebei University , Baoding , P.R. China.
Meng
M
Yu
a College of Chemistry and Environmental Science, Hebei University , Baoding , P.R. China.
Hailei
H
Zhang
a College of Chemistry and Environmental Science, Hebei University , Baoding , P.R. China.
Libin
L
Bai
a College of Chemistry and Environmental Science, Hebei University , Baoding , P.R. China.
Yonggang
Y
Wu
a College of Chemistry and Environmental Science, Hebei University , Baoding , P.R. China.
Sujuan
S
Wang
a College of Chemistry and Environmental Science, Hebei University , Baoding , P.R. China.
Xinwu
X
Ba
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D006367:HeLa Cells; D006801:Humans; D008049:Lipase / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D008744:Methylamines / Q000737:chemistry; D008757:Methylglucosides / Q000737:chemistry*; D058105:Polymerization; D012995:Solubility; D012996:Solutions; D014867:Water / Q000737:chemistry
D000970:Antineoplastic Agents; D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D008689:Methacrylates; D008744:Methylamines; D008757:Methylglucosides; D012996:Solutions; D014867:Water; C093667:Novozyme 435; D008049:Lipase; D003474:Curcumin; C031264:methacryloyl chloride; C023336:trimethylamine
anticancer; biocompatibility; carbohydrate; curcumin; glycopolymer