The Hip Functional Retrieval after Elective Surgery May Be Enhanced by Supplemented Essential Amino Acids.
It is not known whether postsurgery systemic inflammation and plasma amino acid abnormalities are still present during rehabilitation of individuals after elective hip arthroplasty (EHA). Sixty subjects (36 females; age 66.58 ± 8.37 years) were randomized to receive 14-day oral EAAs (8 g/day) or a placebo (maltodextrin). At admission to and discharge from the rehabilitation center, serum C-reactive protein (CRP) and venous plasma amino acid concentrations were determined. Post-EHA hip function was evaluated by Harris hip score (HHS) test. Ten matched healthy subjects served as controls. At baseline, all patients had high CRP levels, considerable reduction in several amino acids, and severely reduced hip function (HHS 40.78 ± 2.70 scores). After treatment, inflammation decreased both in the EAA group and in the placebo group. Only EAA patients significantly improved their levels of glycine, alanine, tyrosine, and total amino acids. In addition, they enhanced the rate of hip function recovery (HHS) (from baseline 41.8 ± 1.15 to 76.37 ± 6.6 versus baseline 39.78 ± 4.89 to 70.0 ± 7.1 in placebo one; p = 0.006). The study documents the persistence of inflammation and plasma amino acid abnormalities in post-EHA rehabilitation phase. EAAs enhance hip function retrieval and improve plasma amino acid abnormalities.
Dipartimento di Medicina Fisica e Riabilitativa, Salvatore Maugeri Foundation, Centro Medico di Nervi, IRCCS, Fondazione Maugeri, Via Missolungi 14, 16167 Nervi, Italy.
Eleonora
E
Baldissarro
Dipartimento di Biologia e Biotecnologie, Unità di Biochimica, Università di Pavia, Via Ferrata 2, 27100 Pavia, Italy.
Roberto
R
Aquilani
Dipartimento di Scienze del Farmaco, Università di Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Federica
F
Boschi
Direzione Scientifica Centrale, IRCCS, Fondazione Maugeri, Via Boezio 28, 27100 Pavia, Italy.
Paola
P
Baiardi
Dipartimento di Biologia e Biotecnologie, Unità di Biochimica, Università di Pavia, Via Ferrata 2, 27100 Pavia, Italy.
Paolo
P
Iadarola
Dipartimento di Biologia e Biotecnologie, Unità di Biochimica, Università di Pavia, Via Ferrata 2, 27100 Pavia, Italy.
Marco
M
Fumagalli
Istituto Scientifico di Lumezzane, IRCCS, Fondazione Maugeri, Via Mazzini 129, 25065 Lumezzane, Italy.
Evasio
E
Pasini
Dipartimento di Biologia e Biotecnologie, Unità di Biochimica, Università di Pavia, Via Ferrata 2, 27100 Pavia, Italy.
Manuela
M
Verri
Dipartimento di Biologia e Biotecnologie, Unità di Biochimica, Università di Pavia, Via Ferrata 2, 27100 Pavia, Italy.
Maurizia
M
Dossena
Consorzio per Valutazioni Biologiche e Farmacologiche, Via Porta 12, 27100 Pavia, Italy.
Arianna
A
Gambino
Dipartimento di Medicina Fisica e Riabilitativa, Salvatore Maugeri Foundation, Centro Medico di Nervi, IRCCS, Fondazione Maugeri, Via Missolungi 14, 16167 Nervi, Italy.
Sharon
S
Cammisuli
Dipartimento di Medicina Molecolare, Unità di Biochimica, Università di Pavia, Via Taramelli 3/B, 27100 Pavia, Italy.
Simona
S
Viglio
D000368:Aged; D000601:Amino Acids, Essential / Q000008:administration & dosage*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D019587:Dietary Supplements; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007249:Inflammation / Q000178:diet therapy* / Q000534:rehabilitation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000178:diet therapy* / Q000534:rehabilitation; D020127:Recovery of Function
D000601:Amino Acids, Essential