The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps.
In 2014, the World Health Organization, the US National Institutes of Health, and global technical partners published a comprehensive roadmap for development of new vaccines against sexually transmitted infections (STIs). Since its publication, progress has been made in several roadmap activities: obtaining better epidemiologic data to establish the public health rationale for STI vaccines, modeling the theoretical impact of future vaccines, advancing basic science research, defining preferred product characteristics for first-generation vaccines, and encouraging investment in STI vaccine development. This article reviews these overarching roadmap activities, provides updates on research and development of individual vaccines against herpes simplex virus, Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum, and discusses important next steps to advance the global roadmap for STI vaccine development.
World Health Organization, Geneva, Switzerland. Electronic address: gottliebs@who.int.
Sami L
SL
Gottlieb
National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Carolyn D
CD
Deal
World Health Organization, Geneva, Switzerland.
Birgitte
B
Giersing
Wits Reproductive Health and HIV Institute, University of the Witswatersrand, Johannesburg, South Africa.
Helen
H
Rees
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gail
G
Bolan
University of Washington, Seattle, WA, USA.
Christine
C
Johnston
University of Sunshine Coast, Queensland Australia and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Peter
P
Timms
University of Toronto, Toronto, ON, Canada.
Scott D
SD
Gray-Owen
Uniformed Services University, Bethesda, MD, USA.
Ann E
AE
Jerse
University of Victoria, Victoria, BC, Canada.
Caroline E
CE
Cameron
World Health Organization, Geneva, Switzerland.
Vasee S
VS
Moorthy
World Health Organization, Geneva, Switzerland.
James
J
Kiarie
World Health Organization, Geneva, Switzerland.
Nathalie
N
Broutet
D035843:Biomedical Research / Q000639:trends; D002690:Chlamydia Infections / Q000517:prevention & control; D006069:Gonorrhea / Q000517:prevention & control; D006561:Herpes Simplex / Q000517:prevention & control; D006801:Humans; D012749:Sexually Transmitted Diseases / Q000517:prevention & control*; D013587:Syphilis / Q000517:prevention & control; D014612:Vaccines / Q000627:therapeutic use*
D014612:Vaccines
Roadmap; STI vaccine development; Sexually transmitted infections; Vaccines