Look into brain energy crisis and membrane pathophysiology in ischemia and reperfusion.
In an ischemic environment, brain tissue responds to oxygen deprivation with the initiation of rapid changes in bioenergetic metabolism to ensure ion and metabolic homeostasis. At the same time, the accelerated cleavage of membrane phospholipids changes membrane composition and increases free fatty acid concentration. Phospholipid breakdown also generates specific messengers that participate in signaling cascades that can either promote neuronal protection or cause injury. The net impact of signaling events affects the final outcome of the stroke. While reoxygenation is a life-saving intervention, it can exacerbate brain damage. Although compromised energy metabolism is restored shortly after reperfusion, alterations in membrane phospholipid composition with subsequent accumulation of lipid oxoderivates are neurotoxic, causing oxidative stress and ischemia-reperfusion (IR) injury. Thus, plasma and mitochondrial membranes are the first responders as well as mediators of IR-induced stress signals. In this review, we focus on ischemia-induced changes in brain energy metabolism and membrane functions as the causal agents of cell stress responses upon reoxygenation. The first part of the review deals with the specificities of neuronal bioenergetics during IR and their impact on metabolic processes. The second part is concentrated on involvement of both plasma and mitochondrial membranes in the production of messengers which can modulate neuroprotective pathways or participate in oxidative/electrophilic stress responses. Although the etiology of IR injury is multifactorial, deciphering the role of membrane and membrane-associated processes in brain damage will uncover new therapeutic agents with the ability to stabilize neuronal membranes and modulate their responses in favor of prosurvival pathways.
a Faculty of Medicine Bratislava, Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry , Comenius University , Bratislava , Slovakia.
Maria
M
Chomova
a Faculty of Medicine Bratislava, Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry , Comenius University , Bratislava , Slovakia.
Ingrid
I
Zitnanova
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D008055:Lipids; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D015427:Reperfusion Injury / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D008055:Lipids
Bioenergetics; F1F0-ATP synthase; brain ischemia-reperfusion injury; cardiolipin; electrophilic stress; membrane phospholipids; mitochondrial supercomplexes