Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease.
Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 2001. It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs. Orbital IgG4-related disease is a recently reported issue that may prove important for the elucidation of the etiology of idiopathic, lymphoplasmacytic or fibrotic disorders of various organs, including the orbits. In this article, we are describing epidemiology and differential diagnostics of IgG4-related orbital disease with particular focus on pseudotumors, MALT lymphomas and lymphocyte/plasma cell infiltrations of the orbit. We are also discussing therapeutic possibilities currently available in the management of the disease.
Department of Oncological and Reconstructive Surgery, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, Poland. Electronic address: olokrista@op.pl.
Krzysztof
K
Oles
Department of Otolaryngology, Collegium Medicum, Jagiellonian University, Kraków, Poland. Electronic address: skladzien.j@interia.pl.
Jacek
J
Sładzień
Department of Cardiac and Vascular Surgery and Transplantology, The Institute of Cardiology, Medical College Jagiellonian University, John Paul II Hospital, Kraków, Poland. Electronic address: krzysztofbartus@gmail.com.
Krzysztof
K
Bartuś
Department of Otolaryngology, Collegium Medicum, Jagiellonian University, Kraków, Poland. Electronic address: johnka@wp.pl.
Joanna
J
Leszczyńska
Department of Otolaryngology, Collegium Medicum, Jagiellonian University, Kraków, Poland. Electronic address: emilabo@gmail.com.
Emila
E
Bojanowska
Department of Oncological and Reconstructive Surgery, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, Poland. Electronic address: lukaszkrakowczyk@wp.pl.
Łukasz
Ł
Krakowczyk
Department of Pain Pharmacology, Institute of Pharmacology, Kraków, Poland. Electronic address: joasia272@onet.eu.
Joanna
J
Mika
D003937:Diagnosis, Differential; D049970:Graves Ophthalmopathy / Q000175:diagnosis; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis; D009916:Orbital Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D016727:Orbital Pseudotumor / Q000175:diagnosis
D007074:Immunoglobulin G
IgG4-related disease; Lymphocyte/plasma cell infiltrations; MALT lymphomas; Orbital pseudotumors