Improving the Stability of Astaxanthin by Microencapsulation in Calcium Alginate Beads.
There has been considerable interest in the biological functions of astaxanthin and its potential applications in the nutraceutical, cosmetics, food, and feed industries in recent years. However, the unstable structure of astaxanthin considerably limits its application. Therefore, this study reports the encapsulation of astaxanthin in calcium alginate beads using the extrusion method to improve its stability. This study also evaluates the stability of the encapsulated astaxanthin under different storage conditions. The evaluation of astaxanthin stability under various environmental factors reveals that temperature is the most influential environmental factor in astaxanthin degradation. Stability analysis shows that, regardless of the formulation used, the content of astaxanthin encapsulated in alginate beads remains above 90% of the original amount after 21 days of storage at 25°C. These results suggest that the proposed technique is a promising way to enhance the stability of other sensitive compounds.
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering Taipei Medical University, Taipei, Taiwan (ROC).
Shen-Fu
SF
Lin
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan (ROC).
Ying-Chen
YC
Chen
Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management College, Taipei, Taiwan (ROC).
Ray-Neng
RN
Chen
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan (ROC).
Ling-Chun
LC
Chen
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan (ROC).
Hsiu-O
HO
Ho
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan (ROC).
Yu-Han
YH
Tsung
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan (ROC).
Ming-Thau
MT
Sheu
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering Taipei Medical University, Taipei, Taiwan (ROC).|Center for General Education, Hsuan Chuang University, Hsinchu, Taiwan (ROC).
Der-Zen
DZ
Liu
D000464:Alginates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D003358:Cosmetics / Q000737:chemistry; D019587:Dietary Supplements; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D019649:Food Industry / Q000379:methods; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D013696:Temperature; D024341:Xanthophylls / Q000737:chemistry
D000464:Alginates; D003358:Cosmetics; D006603:Hexuronic Acids; D024341:Xanthophylls; D020723:Glucuronic Acid; C005948:astaxanthine