Lipoprotein-associated phospholipase A2, and subsequent cardiovascular events and mortality among patients with coronary heart disease.
OBJECTIVE
The objective of this study is to evaluate the relevance of Lp-PLA2to risk prediction among coronary heart disease (CHD) patients.


METHODS
Lp-PLA2activity was measured in 2538 CHD patients included in the Bezafibrate Infarction Prevention (BIP) study.


RESULTS
Adjusting for patient characteristics and traditional risk factors, 1 standard deviation of Lp-PLA2was associated with a hazard ratio (HR) of 1.12 (95% confidence interval (CI): 1.00-1.25) for mortality and 1.03 (0.93-1.14) for cardiovascular events. Lp-PLA2did not significantly improve model discrimination, or calibration nor result in noteworthy reclassification.


CONCLUSIONS
Our results do not support added value of Lp-PLA2for predicting cardiovascular events or mortality among CHD patients beyond traditional risk factor.
a Cardiovascular Epidemiology Unit , Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center , Ramat-Gan , Israel.|b Department of Epidemiology and Preventive Medicine , School of Public Health Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
Michal
M
Benderly
b Department of Epidemiology and Preventive Medicine , School of Public Health Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
Batya
B
Sapir
a Cardiovascular Epidemiology Unit , Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center , Ramat-Gan , Israel.|b Department of Epidemiology and Preventive Medicine , School of Public Health Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
Ofra
O
Kalter-Leibovici
c Department of Medicine and the Brunner Institute for Cardiovascular Research, Sackler Faculty of Medicine , Tel Aviv University, Tel Aviv; Edith Wolfson Medical Center , Holon , Israel.
Reuven
R
Zimlichman
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood* / Q000592:standards; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications*; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
Cohort study; risk factors; risk prediction