High-density electroencephalographic recordings during sleep in children with disorders of consciousness.
BACKGROUND
A large number of studies have investigated neural correlates of consciousness in adults. However, knowledge about brain function in children with disorders of consciousness (DOC) is very limited. We suggest that EEG recordings during sleep are a promising approach. In healthy adults as well as in children, it has been shown that the activity of sleep slow waves (EEG spectral power 1-4.5 Hz), the primary characteristic of deep sleep, is dependent on use during previous wakefulness. Thus the regulation of slow wave activity (SWA) provides indirect insights into brain function during wakefulness.


METHODS
In the present study, we investigated high-density EEG recordings during sleep in ten healthy children and in ten children with acquired brain injury, including five children with DOC and five children with acquired brain injury without DOC. We used the build-up of SWA to quantify SWA regulation.


RESULTS
Children with DOC showed a global reduction in the SWA build-up when compared to both, healthy children and children with acquired brain injury without DOC. This reduction was most pronounced over parietal brain areas. Comparisons within the group of children with DOC revealed that the parietal SWA build-up was the lowest in patients showing poor outcome. Longitudinal measurements during the recovery period showed an increase in parietal SWA build-up from the first to the second sleep recording.


CONCLUSIONS
Our results suggest that the reduced parietal SWA regulation may represent a characteristic topographical marker for brain network dysfunction in children with DOC. In the future, the regulation of SWA might be used as a complementary assessment in adult and paediatric patients with DOC.
Child Development Centre and Paediatric Sleep Disorders Centre, University Children's Hospital Zurich, Switzerland; Rehabilitation Centre Affoltern am Albis, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland.
Anne-Laure
AL
Mouthon
Rehabilitation Centre Affoltern am Albis, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland.
Hubertus J A
HJA
van Hedel
Rehabilitation Centre Affoltern am Albis, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland.
Andreas
A
Meyer-Heim
Child Development Centre and Paediatric Sleep Disorders Centre, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Salome
S
Kurth
Child Development Centre and Paediatric Sleep Disorders Centre, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland.
Maya
M
Ringli
Child Development Centre and Paediatric Sleep Disorders Centre, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland.
Fiona
F
Pugin
Child Development Centre and Paediatric Sleep Disorders Centre, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland; University Clinics for Child and Adolescent Psychiatry, University of Zurich, Switzerland. Electronic address: reto.huber@kispi.uzh.ch.
Reto
R
Huber
D000293:Adolescent; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D003244:Consciousness Disorders / Q000503:physiopathology*; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012890:Sleep / Q000502:physiology*; D013997:Time Factors; D014851:Wakefulness
Children; Disorders of consciousness; EEG; Sleep