Time Course of Macular and Peripapillary Inner Retinal Thickness in Non-arteritic Anterior Ischaemic Optic Neuropathy Using Spectral-Domain Optical Coherence Tomography.
To report a time course of the ganglion cell complex (GCC) and circumpapillary retinal nerve fibre layer (cpRNFL) thicknesses using spectral-domain optical coherence tomography in patients with non-arteritic anterior ischaemic optic neuropathy (NAION), five patients with unilateral NAION were studied (the average age of 66.8 ± 7.8 years old). Forty-one age-matched normal controls were also enrolled. The GCC and cpRNFL thicknesses were measured at the initial visit and at 1, 3, 6, and 12 months using RTVue-100. The GCC thickness and the cpRNFL thickness of the patients were compared with those of the normal controls. The GCC thickness in the NAION patients was 96.49 μm at the initial visit, 84.28 μm at 1 month, 74.26 μm at 3 months, 71.23 μm at 6 months, and 69.51 μm at 12 months. The values at 1, 3, 6, and 12 months were significantly reduced (p< 0.01). The cpRNFL thickness at the initial visit was significantly increased, whereas the values at 6 and 12 months were significantly reduced (p< 0.01). The GCC thickness is more useful for the detection of retinal ganglion cell loss at an early stage than the cpRNFL thickness, because the GCC thickness is unaffected by optic disc swelling at the initial visit, unlike the cpRNFL thickness.
Department of Ophthalmology, Kawasaki Medical School, Kurashiki City, Okayama, Japan; Doctoral Program in Sensory Science, Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki City, Okayama, Japan.
Katsutoshi
K
Goto
Department of Ophthalmology, Kawasaki Medical School, Kurashiki City, Okayama, Japan; Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki City, Okayama, Japan.
Atsushi
A
Miki
Department of Ophthalmology, Kawasaki Medical School , Kurashiki City , Okayama , Japan.
Syunsuke
S
Araki
Department of Ophthalmology, Kawasaki Medical School , Kurashiki City , Okayama , Japan.
Kenichi
K
Mizukawa
Department of Ophthalmology, Kawasaki Medical School , Kurashiki City , Okayama , Japan.
Masaki
M
Nakagawa
Department of Ophthalmology, Kawasaki Medical School , Kurashiki City , Okayama , Japan.
Go
G
Takizawa
Department of Ophthalmology, Kawasaki Medical School , Kurashiki City , Okayama , Japan.
Yoshiaki
Y
Ieki
Department of Ophthalmology, Kawasaki Medical School , Kurashiki City , Okayama , Japan.
Junichi
J
Kiryu
Anterior ischaemic optic neuropathy; ganglion cell complex; retinal ganglion cell; retinal nerve fibre layer; spectral-domain optical coherence tomography