Dissolution and drug release profiles of phosphate glasses doped with high valency oxides.
This paper investigates phosphate glasses incorporating vanadium and molybdenum oxides for effective management of dissolution and drug release. These glass formulations are found to reduce the rate of dissolution from the glass surfaces. The drug functional groups of vancomycin molecules loaded by immersion showed stronger hydrogen bonding with Vanadium doped glasses and consequently lower rate of drug release over 2 weeks indicating better surface attachment with the drug molecules and slow drug release profiles. This can be explained by the strong adherence of drug molecules to glass surfaces compared with the molybdenum containing glasses (PM5 and PM10). The strong attachment relates to hydrogen bonding between the amino-functional groups of vancomycin and the hydrated P-O-H groups in the glass network. In conclusion, the rate of dissolution of doped glasses and the rate of drug release can be administered to deliver the drug molecules over weeks.
Department of Biomaterials, National Research Centre, El-Tahrir Street, Dokki, Cairo, Egypt. emadmeliegy@hotmail.com.
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El-Meliegy
Department of Biomaterials, National Research Centre, El-Tahrir Street, Dokki, Cairo, Egypt.
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Farag
Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Grays Inn Road, London, WC1X 8LD, UK.
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Knowles
D000900:Anti-Bacterial Agents / Q000737:chemistry; D001672:Biocompatible Materials; D065546:Drug Liberation; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008982:Molybdenum / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D010710:Phosphates; D017968:Vanadium Compounds / Q000737:chemistry*; D014640:Vancomycin / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D007477:Ions; D010087:Oxides; D010710:Phosphates; D017968:Vanadium Compounds; D014640:Vancomycin; D008982:Molybdenum