Synthesis of isotopically labelled 2-isopropylthioxanthone from 2,2'-dithiosalicylic acid and deuterium cumene.
Two efficient synthetic routes of stable deuterium labelled 2-isopropylthioxanthone were presented with 98.1% and 98.8% isotopic abundance in acceptable yields and excellent chemical purities. Their structures and the isotope-abundance were confirmed according to proton nuclear magnetic resonance and liquid chromatography-mass spectrometry.
Research and Development Center, Shanghai Research Institute of Chemical Industry, 345 East Yunling Road, Shanghai, 200062, China.
Chao
C
Fang
Research and Development Center, Shanghai Research Institute of Chemical Industry, 345 East Yunling Road, Shanghai, 200062, China.
Weicheng
W
Yang
Research and Development Center, Shanghai Research Institute of Chemical Industry, 345 East Yunling Road, Shanghai, 200062, China.
Chao
C
Yang
Research and Development Center, Shanghai Research Institute of Chemical Industry, 345 East Yunling Road, Shanghai, 200062, China.
Haoran
H
Wang
Research and Development Center, Shanghai Research Institute of Chemical Industry, 345 East Yunling Road, Shanghai, 200062, China.
Kai
K
Sun
Research and Development Center, Shanghai Research Institute of Chemical Industry, 345 East Yunling Road, Shanghai, 200062, China.
Yong
Y
Luo
D001555:Benzene Derivatives / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003903:Deuterium / Q000737:chemistry*; D007553:Isotope Labeling; D011854:Radiochemistry; D012459:Salicylates / Q000737:chemistry*; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry*
D001555:Benzene Derivatives; D012459:Salicylates; D044004:Xanthones; C514852:isopropyl thioxanthone; C026779:dithiosalicylic acid; C015763:cumene; D003903:Deuterium
2-isopropylthioxanthone; deuterium cumene; labelled internal standards; two synthetic routes