Necessary and sufficient conditions for protocell growth.
We consider a generic protocell model consisting of any conservative chemical reaction network embedded within a membrane. The membrane results from the self-assembly of a membrane precursor and is semi-permeable to some nutrients. Nutrients are metabolized into all other species including the membrane precursor, and the membrane grows in area and the protocell in volume. Faithful replication through cell growth and division requires a doubling of both cell volume and surface area every division time (thus leading to a periodic surface area-to-volume ratio) and also requires periodic concentrations of the cell constituents. Building upon these basic considerations, we prove necessary and sufficient conditions pertaining to the chemical reaction network for such a regime to be met. A simple necessary condition is that every moiety must be fed. A stronger necessary condition implies that every siphon must be either fed, or connected to species outside the siphon through a pass reaction capable of transferring net positive mass into the siphon. And in the case of nutrient uptake through passive diffusion and of constant surface area-to-volume ratio, a sufficient condition for the existence of a fixed point is that every siphon be fed. These necessary and sufficient conditions hold for any chemical reaction kinetics, membrane parameters or nutrient flux diffusion constants.
Laboratoire d'Informatique, École Polytechnique, Palaiseau, France. bigan.erwan@orange.fr.|Laboratoire Matière et Systèmes Complexes, Université Paris Diderot, Paris, France. bigan.erwan@orange.fr.
Erwan
E
Bigan
Laboratoire de Recherche en Informatique, CNRS and Université Paris Sud, Orsay, France.
Loïc
L
Paulevé
Laboratoire d'Informatique, École Polytechnique, Palaiseau, France.
Jean-Marc
JM
Steyaert
Laboratoire Matière et Systèmes Complexes, Université Paris Diderot, Paris, France.
Stéphane
S
Douady
D002453:Cell Cycle; D002462:Cell Membrane / Q000502:physiology*; D048429:Cell Size; D002477:Cells / Q000166:cytology / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological
Chemical reaction network; Persistence; Protocell; Siphons