Matrilin-3 Role in Cartilage Development and Osteoarthritis.
The extracellular matrix (ECM) of cartilage performs essential functions in differentiation and chondroprogenitor cell maintenance during development and regeneration. Here, we discuss the vital role of matrilin-3, an ECM protein involved in cartilage development and potential osteoarthritis pathomechanisms. As an adaptor protein, matrilin-3 binds to collagen IX to form a filamentous network around cells. Matrilin-3 is an essential component during cartilage development and ossification. In addition, it interacts directly or indirectly with transforming growth factor β (TGF-β), and bone morphogenetic protein 2 (BMP2) eventually regulates chondrocyte proliferation and hypertrophic differentiation. Interestingly, matrilin-3 increases interleukin receptor antagonists (IL-Ra) in chondrocytes, suggesting its role in the suppression of IL-1β-mediated inflammatory action. Matrilin-3 downregulates the expression of matrix-degrading enzymes, such as a disintegrin metalloproteinase with thrombospondin motifs 4 (ADAMTS4) and ADAMTS5, matrix metalloproteinase 13 (MMP13), and collagen X, a hypertrophy marker during development and inflammatory conditions. Matrilin-3 essentially enhances collagen II and aggrecan expression, which are required to maintain the tensile strength and elasticity of cartilage, respectively. Interestingly, despite these attributes, matrilin-3 induces osteoarthritis-associated markers in chondrocytes in a concentration-dependent manner. Existing data provide insights into the critical role of matrilin-3 in inflammation, matrix degradation, and matrix formation in cartilage development and osteoarthritis.
School of Integrative Engineering, Chung-Ang University, Seoul 06911, Korea. manjunatha.muttigi@gmail.com.|Department of Biomedical Science, CHA University, Seongnam-Si 13488, Korea. manjunatha.muttigi@gmail.com.
Manjunatha S
MS
Muttigi
Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Korea. hanib@cha.ac.kr.
Inbo
I
Han
Department of Biomedical Engineering, Collage of Medicine, Kyung Hee University, Seoul 02447, Korea. sigmoidus@khu.ac.kr.
Hun-Kuk
HK
Park
School of Integrative Engineering, Chung-Ang University, Seoul 06911, Korea. heyshoo@cau.ac.kr.
Hansoo
H
Park
Department of Biomedical Science, CHA University, Seongnam-Si 13488, Korea. soohong@cha.ac.kr.
Soo-Hong
SH
Lee
D000818:Animals; D002356:Cartilage / Q000254:growth & development* / Q000378:metabolism; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D020219:Chondrogenesis; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology; D064235:Matrilin Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D010003:Osteoarthritis / Q000378:metabolism*; D010012:Osteogenesis
D064235:Matrilin Proteins
cartilage; extracellular matrix; hypertrophy; interleukin receptor antagonist; matrilin-3; osteoarthritis