Office-based biopsies for laryngeal lesions: Analysis of consecutive 581 cases.
Office-based biopsy (OBB) is widely used to diagnose suspicious laryngeal lesions. However, its routine use is still controversial and the algorithm for clinical strategy is not concrete. We tried to evaluate the accuracy of OBB as a diagnostic tool for laryngeal malignancy.



Medical data of 581 patients undergoing OBB were reviewed. Diagnostic values of OBB were analyzed for malignancy and malignancy/premalignancy. False negative rates (FNRs) were analyzed according to subsites, lesion sizes, and morphology.



The collection rate of adequate specimens was 99.1%, and there were no complications during OBB. The false omission rates for malignancy of benign lesion; mild, moderate, and severe dysplasia; and carcinoma in situ (CIS) were 5.1%, 11.9%, 14.3%, 50.0%, and 100.0%, respectively. Sensitivity, specificity, positive predictive value, and negative predictive value for malignancy in OBB were 78.2%, 100.0%, 100.0%, and 87.3%, respectively. Those for malignancy/premalignancy in OBB were 88.2%, 86.7%, 85.7%, and 89.1%, respectively. The high FNRs were reported in glottis lesions (27.0%) and small lesions below 1 cm (27.5%). Morphologically fungating lesions showed low FNR (9.1%) compared to nonfungating ones.



Office-based biopsy could be used as an initial diagnostic tool for laryngeal malignancy for early detection and avoidance of general anesthesia. However, operative re-biopsy should be considered when severe dysplasia or CIS were reported in OBB, or when the lesions are clinically suspicious for malignancy.



4. Laryngoscope, 126:2513-2519, 2016.
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan. chawonjae@gmail.com.|Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do. chawonjae@gmail.com.
Wonjae
0000-0001-7292-9474
W
Cha
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan.
Byung-Woo
BW
Yoon
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan.
Jeon Yeob
JY
Jang
Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do.|Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do.
Jin Choon
JC
Lee
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan.|Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do.
Byung Joo
BJ
Lee
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan.|Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do.
Soo-Geun
SG
Wang
Department of Otolaryngology-Head and Neck Surgery, Inje University Ilsan Paik Hospital and Inje University School of Medicine, Goyang, Republic of Korea.
Jae Keun
JK
Cho
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan.
Ilyoung
I
Cho
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000556:Ambulatory Surgical Procedures / Q000379:methods / Q000706:statistics & numerical data*; D001706:Biopsy / Q000379:methods / Q000706:statistics & numerical data*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D055815:Young Adult
Office-based biopsy; diagnostic accuracy; endoscopic; larynx; malignancy