Defining cross presentation for a wider audience.
Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-dependent cross presentation pathway, but numerous pathways for transfer of antigenic material from a donor to a recipient cell followed by subsequent MHC-I-restricted presentation have been established, including transfer of protein antigen, peptide, RNA, DNA or even peptide-MHC-I complexes. The extent to which each of these pathways generates overlapping or unique peptide repertoires is unknown, as is the contribution of each of these pathways to generation of protective CD8+ T cells during infection or anti-tumor immune responses.
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA. Electronic address: ccn1@psu.edu.
Christopher C
CC
Norbury
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D000941:Antigens / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D045142:Cross-Priming; D004705:Endocytosis; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000276:immunology*; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology*; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport
D018528:ATP-Binding Cassette Transporters; D000941:Antigens; D015395:Histocompatibility Antigens Class I; D010455:Peptides; C477327:transporter associated with antigen processing (TAP)