Interaction of the renin angiotensin and cox systems in the kidney.
Cyclooxygenase-2 (COX-2) plays an important role in mediating actions of the renin-angiotensin system (RAS). This review sheds light on the recent developments regarding the complex interactions between components of RAS and COX-2; and their implications on renal function and disease. COX-2 is believed to counter regulate the effects of RAS activation and therefore counter balance the vasoconstriction effect of Ang II. In kidney, under normal conditions, these systems are essential for maintaining a balance between vasodilation and vasoconstriction. However, recent studies suggested a pivotal role for this interplay in pathology. COX-2 increases the renin release and Ang II formation leading to increase in blood pressure. COX-2 is also associated with diabetic nephropathy, where its upregulation in the kidney contributes to glomerular injury and albuminuria. Selective inhibition of COX-2 retards the progression of renal injury. COX-2 also mediates the pathologic effects of the (Pro)renin receptor (PRR) in the kidney. In summary, this review discusses the interaction between the RAS and COX-2 in health and disease.
Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA.
Syed S
SS
Quadri
Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA.
Silas A
SA
Culver
Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA.
Caixia
C
Li
Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA, hms7a@virginia.edu.
Helmy M
HM
Siragy
D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology*
D000809:Angiotensins; D051546:Cyclooxygenase 2