Sexually-transmitted seronegative HCV infection in an HIV-positive post-liver transplant recipient. Case report and review of the literature.
We report an HIV-positive patient post liver transplant for non-alcoholic steatohepatitis. Posttransplant liver enzymes became persistently elevated, however HCV antibody was repeatedly negative. Nucleic acid testing subsequently revealed ongoing HCV viremia. Exposure to HCV was on the basis of sexual transmission. The patient was subsequently successfully treated with sofosbuvir/ledipasvir.
Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Faisal
F
Alshatti
Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Sarvee
S
Moosavi
Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address: Eric.Yoshida@vch.ca.
Eric M
EM
Yoshida
Division of AIDS, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address: mhull@cfenet.ubc.ca.
Mark W
MW
Hull
D000998:Antiviral Agents / Q000008:administration & dosage; D001562:Benzimidazoles / Q000008:administration & dosage; D005449:Fluorenes / Q000008:administration & dosage; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D015229:Sexually Transmitted Diseases, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D000069474:Sofosbuvir / Q000008:administration & dosage; D000637:Transaminases / Q000097:blood; D066027:Transplant Recipients; D016896:Treatment Outcome
D000998:Antiviral Agents; D001562:Benzimidazoles; D005449:Fluorenes; D018937:Hepatitis C Antibodies; D012367:RNA, Viral; C586541:ledipasvir; D000637:Transaminases; D000069474:Sofosbuvir
Acute hepatitis C infection; HIV co-infection; Men who have sex with men; Post-transplantation; Sexual transmission