Drug loaded and ethylcellulose coated mesoporous silica for controlled drug release prepared using a pilot scale fluid bed system.
The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat the loaded particles using one single pilot scale fluid bed system equipped with a Wurster insert. Mesoporous silica particles (Davisil(®)) with a size ranging from 310 to 500μm and an average pore diameter of 15nm were loaded with paracetamol to 18.8% drug content. Subsequently, loaded cores were coated with ethylcellulose to obtain controlled drug release. Coating processing variables were varied following a full factorial design and their effect on drug release was assessed. Increasing coating solution feed rate and decreasing fluidizing air temperature were found to increase drug release rates. Increasing pore former level and decreasing coating level were found to increase drug release rates. The release medium's osmolality was varied using different sodium chloride concentrations, which was found to affect drug release rates. The results of this study clearly indicate the potential of non-ordered, non-spherical mesoporous silica as a reservoir carrier for the controlled release of drugs. Although non-spherical, we were able to reproducibly coat this carrier using a bottom spray fluid bed system. However, a major hurdle that needs to be tackled is the attrition the material suffers from during fluid bed processing.
Drug Delivery and Disposition, KU Leuven, Leuven, Belgium.
Youcef Chakib
YC
Hacene
Drug Delivery and Disposition, KU Leuven, Leuven, Belgium.
Abhishek
A
Singh
Drug Delivery and Disposition, KU Leuven, Leuven, Belgium. Electronic address: guy.vandenmooter@pharm.kuleuven.be.
Guy
G
Van den Mooter
D000082:Acetaminophen / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D009994:Osmolar Concentration; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D000082:Acetaminophen; D012822:Silicon Dioxide; C013517:ethyl cellulose; D002482:Cellulose
Controlled drug release; Drug loading; Ethylcellulose; Fluid bed coating; Mesoporous silica; PVP K30