Atypical onset of bicalutamide-induced liver injury.
Anti-androgen therapy is the leading treatment for advanced prostate cancer and is commonly used for neoadjuvant or adjuvant treatment. Bicalutamide is a non-steroidal anti-androgen, used during the initiation of androgen deprivation therapy along with a luteinizing hormone-releasing hormone agonist to reduce the symptoms of tumor-related flares in patients with advanced prostate cancer. As side effects, bicalutamide can cause fatigue, gynecomastia, and decreased libido through competitive androgen receptor blockade. Additionally, although not as common, drug-induced liver injury has also been reported. Herein, we report a case of hepatotoxicity secondary to bicalutamide use. Typically, bicalutamide-induced hepatotoxicity develops after a few days; however, in this case, hepatic injury occurred 5 mo after treatment initiation. Based on this rare case of delayed liver injury, we recommend careful monitoring of liver function throughout bicalutamide treatment for prostate cancer.
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Gee Young
GY
Yun
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Seok Hyun
SH
Kim
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Seok Won
SW
Kim
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Jong Seok
JS
Joo
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Ju Seok
JS
Kim
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Eaum Seok
ES
Lee
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Byung Seok
BS
Lee
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Sun Hyoung
SH
Kang
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Hee Seok
HS
Moon
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Jae Kyu
JK
Sung
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Heon Young
HY
Lee
Gee Young Yun, Seok Hyun Kim, Seok Won Kim, Jong Seok Joo, Ju Seok Kim, Eaum Seok Lee, Byung Seok Lee, Sun Hyoung Kang, Hee Seok Moon, Jae Kyu Sung, Heon Young Lee, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea.
Kyung Hee
KH
Kim
D000726:Androgen Antagonists / Q000009:adverse effects*; D000813:Anilides / Q000009:adverse effects*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D009570:Nitriles / Q000009:adverse effects*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013997:Time Factors; D014105:Tosyl Compounds / Q000009:adverse effects*; D016896:Treatment Outcome
D000726:Androgen Antagonists; D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide
Bicalutamide; Drug-induced liver injury; Prostate neoplasm