Orchestrating Wnt signalling for metabolic liver zonation.
Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.
Cancer Research Program of the Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany.
Walter
W
Birchmeier
D006801:Humans; D008099:Liver / Q000166:cytology*; D015398:Signal Transduction; D051153:Wnt Proteins; D051176:beta Catenin
D051153:Wnt Proteins; D051176:beta Catenin