Niacin and olive oil promote skewing to the M2 phenotype in bone marrow-derived macrophages of mice with metabolic syndrome.
Metabolic syndrome (MetS) is associated with obesity, dyslipemia, type 2 diabetes and chronic low-grade inflammation. The aim of this study was to determine the role of high-fat low-cholesterol diets (HFLCDs) rich in SFAs (HFLCD-SFAs), MUFAs (HFLCD-MUFAs) or MUFAs plus omega-3 long-chain PUFAs (HFLCD-PUFAs) on polarisation and inflammatory potential in bone marrow-derived macrophages (BMDMs) from niacin (NA)-treated Lep(ob/ob)LDLR(-/-) mice. Animals fed with HFLCD-SFAs had increased weight and serum triglycerides, and their BMDMs accumulated triglycerides over the animals fed with HFLCD-MUFAs or -PUFAs. Furthermore, BMDMs from animals fed with HFLCD-SFAs were polarised towards the M1 phenotype with functional competence to produce pro-inflammatory cytokines, whereas BMDMs from animals fed with HFLCD-MUFAs or -PUFAs were skewed to the anti-inflammatory M2 phenotype. These findings open opportunities for developing novel nutritional strategies with olive oil as the most important dietary source of MUFAs (notably oleic acid) to prevent development and progression of metabolic complications in the NA-treated MetS.
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain. delapaz@us.es muriana@ig.csic.es.
Sergio
S
Montserrat-de la Paz
Maria C
MC
Naranjo
Sergio
S
Lopez
Rocio
R
Abia
Francisco J G
FJ
Muriana
Beatriz
B
Bermudez
D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000378:metabolism; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D007249:Inflammation; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000378:metabolism* / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D009525:Niacin / Q000008:administration & dosage*; D019301:Oleic Acid / Q000494:pharmacology; D000069463:Olive Oil / Q000008:administration & dosage*; D010641:Phenotype; D014280:Triglycerides / Q000097:blood
D016207:Cytokines; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D000069463:Olive Oil; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D009525:Niacin; D019301:Oleic Acid; D002784:Cholesterol; D015118:Eicosapentaenoic Acid