Biokinetics of 90Sr in Male Nonhuman Primates.
The current study tests the hypothesis that the biokinetics of Sr can be represented by simplification of the ICRP publication 78 Sr model. Default and proposed models were evaluated by their ability to predict injected activity and more thoroughly define the activity residing in the skeleton of rhesus monkeys. The data obtained from studies done by Patricia Durbin and her colleagues at the Lawrence Berkley National Laboratory were used to create a profile of the activity residing in the skeleton at the time of sacrifice. Post mortem data along with periodic whole body count data were used to optimize the biokinetic parameters using the Integrated Modules for Bioassay Analysis (IMBA), Weighted Likelihood Monte-Carlo Sampling (WeLMoS) program to better predict the intake and fit of the bioassay data. Analysis of the default ICRP 78 parameters resulted in an overprediction of activity in the skeleton for a male cohort by as much as 180%. Using Monte Carlo sampling methods, three models were developed and optimized for a composite cohort of male monkeys. Of the three developed models, one model proved to have the best predictive capabilities. The optimized model C obtained for the male cohort was then tested on a validation cohort to test predictive capabilities. Using the optimized model C parameters, the ability to predict activity in the skeleton was improved in comparison to ICRP 78. Prediction of the intake from bioassay data was also improved by a factor of 2 in comparison to ICRP 78. The results suggest that the modified transfer rates of model C could be used as default parameters for biokinetic nonhuman primate modeling and potentially extrapolated to humans.
*Idaho State University, Pocatello-Department of Nuclear Engineering and Health Physics, Pocatello, ID 83209-8065; †Lovelace Respiratory Research Institute, Albuquerque, NM.
Eric S
ES
Krage
Deepesh
D
Poudel
Jasen
J
Swanson
Raymond A
RA
Guilmette
Richard R
RR
Brey
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D015233:Models, Statistical; D009928:Organ Specificity; D013326:Strontium Radioisotopes / Q000097:blood* / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*
D013326:Strontium Radioisotopes