Low-Power, 8-Channel EEG Recorder and Seizure Detector ASIC for a Subdermal Implantable System.
EEG remains the mainstay test for the diagnosis and treatment of patients with epilepsy. Unfortunately, ambulatory EEG systems are far from ideal for patients who have infrequent seizures. These systems only last up to 3 days and if a seizure is not captured during the recordings, a definite diagnosis of the patient's condition cannot be given. This work aims to address this need by proposing a subdermal implantable, eight-channel EEG recorder and seizure detector that has two modes of operation: diagnosis and seizure counting. In the diagnosis mode, EEG is continuously recorded until a number of seizures are recorded. In the seizure counting mode, the system uses a low-power algorithm to track the number of seizures a patient has, providing doctors with a reliable count to help determine medication efficacy or other clinical endpoint. An ASIC that implements the EEG recording and seizure detection algorithm was designed and fabricated in a 0.18 μm CMOS process. The ASIC includes eight EEG channels and is designed to minimize the system's power and size. The result is a power-efficient analog front end that requires 2.75 μW per channel in diagnosis mode and 0.84 μW per channel in seizure counting mode. Both modes have an input referred noise of approximately 1.1 μVrms.
Bruno G
BG
Do Valle
Sydney S
SS
Cash
Charles G
CG
Sodini
D000465:Algorithms; D004566:Electrodes; D004569:Electroencephalography; D004867:Equipment Design; D006801:Humans; D018670:Monitoring, Ambulatory; D012640:Seizures / Q000175:diagnosis* / Q000000981:diagnostic imaging