Rhodotorula fungemia: Report of two cases in Sfax (Tunisia).
Rhodotorula is emerging as an important cause of nosocomial and opportunistic infections. We present two cases of Rhodotorula mucilaginosa fungemia diagnosed at our hospital during the last decade. The first case was of a term neonate who presented congenital heart disease (interventricular communication) and body dysmorphic disorder. He was admitted for respiratory failure and sepsis. The second case involved in a 33-year-old woman that had Hodgkinien lymphoma associated to tuberculosis. Identification was performed using commercial systems and confirmed by PCR sequencing of internal transcribed spacer, ITS1 and ITS2 regions of rDNA. Antifungal susceptibility tested by sensititre yeast revealed susceptibility to amphotericin B and resistance to fluconazole for the two strains. These cases emphasize the emerging importance of Rhodotorula sp. as a pathogen and it must be considered a potential pathogen in patients with immunosupression and with central venous catheters. Correct identification is mandatory for appropriate management, as Rhodotorula spp. are resistant to antifungal agents, such as fluconazole.
Fungal and parasitic molecular biology laboratory, school of medicine, 3029 Sfax, Tunisia.
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Guidara
Fungal and parasitic molecular biology laboratory, school of medicine, 3029 Sfax, Tunisia.
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Trabelsi
Fungal and parasitic molecular biology laboratory, school of medicine, 3029 Sfax, Tunisia.
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Neji
Fungal and parasitic molecular biology laboratory, school of medicine, 3029 Sfax, Tunisia.
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Cheikhrouhou
Fungal and parasitic molecular biology laboratory, school of medicine, 3029 Sfax, Tunisia.
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Sellami
Fungal and parasitic molecular biology laboratory, school of medicine, 3029 Sfax, Tunisia.
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Makni
Fungal and parasitic molecular biology laboratory, school of medicine, 3029 Sfax, Tunisia. Electronic address: ali.ayadi@rns.tn.
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Ayadi
D000328:Adult; D005260:Female; D016469:Fungemia / Q000175:diagnosis* / Q000382:microbiology; D006330:Heart Defects, Congenital / Q000150:complications / Q000382:microbiology; D006689:Hodgkin Disease / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000382:microbiology; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000382:microbiology; D012248:Rhodotorula / Q000302:isolation & purification*; D014416:Tunisia
Fongémie; Fungemia; Rhodotorula; Sensibilité aux antifongiques; Sfax; Susceptibility profile; Tunisia; Tunisie