Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population.
The doublecortin domain-containing 2 (DCDC2) gene, which is located on chromosome 6p22.1, has been widely suggested to be a candidate gene for dyslexia, but its role in typical reading development over time remains to be clarified. In the present study, we explored the role of DCDC2 in contributing to the individual differences in reading development from ages 6 to 11 years by analysing data from 284 unrelated children who were participating in the Chinese Longitudinal Study of Reading Development (CLSRD). The associations of eight single nucleotide polymorphisms (SNPs) in DCDC2 with the latent intercept and slope of children's reading scores were examined in the first step. There was significant support for an association of rs807724 with the intercept for the reading comprehension measure of reading fluency, and the minor "G" allele was associated with poor reading performance. Next, we further tested the rs807724 SNP in association with the reading ability at each tested time and revealed that, in addition to significant associations with the two main reading measures (reading fluency and Chinese character reading) over multiple testing occasions, this SNP also showed associations with reading-related cognitive skills, including morphological production, orthographic judgment and phonological processing skills (rapid number naming, phoneme deletion, and tone detection). This study provides support for DCDC2 as a risk gene for reading disability and suggests that this gene is also operative for typical reading development in the Han population.
Department of Psychology, Chengdu Medical College, Chengdu, China.|ResearchCenter for Applied Psychology of Sichuan, Chengdu Medical College, Chengdu, China.|State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Yuping
Y
Zhang
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Jun
J
Li
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Shuang
S
Song
Department of Psychology, University of Michigan, Ann Arbor, Michigan, United States of America.
Twila
T
Tardif
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, United States of America.|Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, United States of America.|Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Margit
M
Burmeister
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, United States of America.|Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, United States of America.
Sandra M
SM
Villafuerte
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Mengmeng
M
Su
Department of Psychology, The Chinese University of Hong Kong, Hong Kong, China.
Catherine
C
McBride
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.|State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Hua
H
Shu
D002648:Child; D002681:China / Q000453:epidemiology; D004410:Dyslexia / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011932:Reading
C510451:DCDC2 protein, human; D008869:Microtubule-Associated Proteins