Clinical and urodynamic effects of baclofen in women with functional bladder outlet obstruction: Preliminary report.
OBJECTIVE
To investigate the efficacy and urodynamic effects of baclofen in women with functional bladder outlet obstruction.


METHODS
Between January 2011 and December 2012, women who underwent baclofen treatment for functional bladder outlet obstruction, defined as <15 mL/s maximum flow rate and >20 cmH2 O detrusor pressure at maximum flow rate, but without significant anatomic causes, were retrospectively reviewed. Urodynamic variables at baseline and after 12 weeks of treatment were compared.


RESULTS
Twenty women with functional bladder outlet obstruction underwent 12 weeks of baclofen treatment (oral baclofen 5 mg, three times daily). All patients reported improvement in voiding dysfunction symptoms after treatment, and no significant adverse effects were found on review of medical records. All patients underwent urodynamic studies after 12 weeks' treatment. Voided volume, voiding efficiency and maximum flow rate at voiding cystometry were significantly improved (mean, 273 vs. 368 mL, P = 0.002; 62.8% vs. 73.6%, P <0.001, and 10.3 vs. 11.6 mL/s, P = 0.046; respectively). Moreover, baclofen did not affect continence function, as indicated by non-significant changes in the parameters of urethral pressure profiles.


CONCLUSIONS
Oral baclofen can improve symptoms of voiding dysfunction, voided volume, voiding efficiency and maximum flow rate in women with functional bladder outlet obstruction. None of the patients experienced intolerable side-effects. Thus, oral baclofen may be used as an initial treatment for women with symptoms of voiding dysfunction.
Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and National Taiwan University Hospital, New Taipei, Taiwan.
Chi-Hau
CH
Chen
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan.
Sheng-Mou
SM
Hsiao
Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and National Taiwan University Hospital, New Taipei, Taiwan.
Ting-Chen
TC
Chang
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan.
Wen-Yih
WY
Wu
Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and National Taiwan University Hospital, New Taipei, Taiwan.
Ho-Hsiung
HH
Lin
D000284:Administration, Oral; D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D058786:GABA-B Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy*; D014563:Urodynamics / Q000187:drug effects*
D058786:GABA-B Receptor Agonists; D001418:Baclofen
baclofen; bladder outlet obstruction; voiding dysfunction