The Use of Plasma-Derived Complement C1-Esterase Inhibitor Concentrate (Berinert®) in the Treatment of Angiotensin Converting Enzyme-Inhibitor Related Angioedema.
Angioedema of the upper airways is a severe and potentially life-threatening condition. The incidence has been increasing in the past two decades, primarily due to pharmaceuticals influencing the generation or degradation of the vasoactive molecule bradykinin. Plasma-derived C1-esterase inhibitor concentrate is a well-established treatment option of hereditary and acquired complement C1-esterase inhibitor deficiency, which are also mediated by an increased level of bradykinin resulting in recurrent angioedema. We here present a case of severe angiotensin converting enzyme-inhibitor related angioedema (ACEi-AE) of the hypopharynx that completely resolved rapidly after the infusion of plasma-derived C1-inhibitor concentrate adding to the sparse reports in the existing literature.
Department of Otorhinolaryngology and Maxillofacial Surgery, Køge Sygehus, Lykkebaekvej 1, 4600 Køge, Denmark.
Thorbjørn
T
Hermanrud
Department of Otorhinolaryngology and Maxillofacial Surgery, Køge Sygehus, Lykkebaekvej 1, 4600 Køge, Denmark.
Nicolaj
N
Duus
Department of Dermatology and Allergy Centre, Odense University Hospital, Sønder Boulevard 29, 5000 Odense C, Denmark.
Anette
A
Bygum
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen East, Denmark.
Eva Rye
ER
Rasmussen