[Risk factors of cholecystitis after radical gastrectomy for gastric cancer].
OBJECTIVE
To investigate the risk factor of cholecystitis after radical gastrectomy for gastric cancer.


METHODS
Clinicpathological data of 553 gastric cancer patients with normal gallbladders undergoing radical gastrectomy in Tianjin Medical University Cancer Institute and Hospital between March 2013 and March 2015 were analyzed retrospectively. Univariate and multivariate analysis were applied to evaluate factors influencing the cholecystitis after radical gastrectomy using log-rank and logistic regression model.


RESULTS
There were 360 males and 193 females with a median age of 60 years. All patients were followed up from 6 months to 2 years. The incidence of cholecystitis after radical gastrectomy for gastric cancer was 33.1%(183/553), while incidence of cholecystolithiasis was 4.9%(27/553). In addition, the cholecystitis incidence of patients with No.12 lymph node cleaning was 39.6%(89/225), while with No.8a lymph node cleaning was 38.0%(151/397), with No.5 lymph node cleaning was 38.0%(68/179), with No.7 lymph node cleaning was 34.4%(138/402), with No.9 lymph node cleaning was 34.7%(136/392). Univariate log-rank test indicated that the lymphadenectomy of No.8a(χ(2)=15.530, P=0.000), No.12 group(χ(2)=7.157, P=0.007) and surgical methods (χ(2)=7.427, P=0.024) were significantly associated with cholecystitis after radical gastrectomy. Multivariate analysis showed that the lymphadenectomy of No.8a was independent factor of cholecystitis after radical gastrectomy (OR=2.016, 95% CI:1.244 to 3.267, P=0.004).


CONCLUSIONS
Vagal nerve trunk and sympathetic ganglion should be protected carefully during No.8a lymphadenectomy in radical gastrectomy for gastric cancer, in order to reduce the incidence of postoperative cholecystitis.
Department of General Surgery, Baotou Eighth Hospital, Baotou Inner Mongolia 014040, China.
Tuankui
T
Guo
Department of Gastroenterology, Baotou Fourth Hospital, Baotou Inner Mongolia 014000, China.
Liqing
L
Yang
Department of General Surgery, Baotou Eighth Hospital, Baotou Inner Mongolia 014040, China.
Yun
Y
Liu
Department of General Surgery, Baotou Eighth Hospital, Baotou Inner Mongolia 014040, China.
Qinggang
Q
Tian
National Clinical Research Center of Cancer, Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Xiaona
X
Wang
National Clinical Research Center of Cancer, Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Bin
B
Li
National Clinical Research Center of Cancer, Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Yachao
Y
Hou
National Clinical Research Center of Cancer, Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Hongmin
H
Liu
National Clinical Research Center of Cancer, Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. tjlianghan@126.com.
Han
H
Liang
D002764:Cholecystitis / Q000453:epidemiology*; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D016015:Logistic Models; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000601:surgery*