From Diagnosis to Treatment: Clinical Applications of Nanotechnology in Thoracic Surgery.
Nanotechnology is an emerging field with potential as an adjunct to cancer therapy, particularly thoracic surgery. Therapy can be delivered to tumors in a more targeted fashion, with less systemic toxicity. Nanoparticles may aid in diagnosis, preoperative characterization, and intraoperative localization of thoracic tumors and their lymphatics. Focused research into nanotechnology's ability to deliver both diagnostics and therapeutics has led to the development of nanotheranostics, which promises to improve the treatment of thoracic malignancies through enhanced tumor targeting, controlled drug delivery, and therapeutic monitoring. This article reviews nanoplatforms, their unique properties, and the potential for clinical application in thoracic surgery.
Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, 15 Francis St, Boston, MA 02115, USA.
Christopher S
CS
Digesu
Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, 15 Francis St, Boston, MA 02115, USA.
Sophie C
SC
Hofferberth
Department of Biomedical Engineering, Metcalf Science Center, Boston University, SCI 518, 590 Commonwealth Avenue, Boston, MA 02215, USA; Department of Chemistry, Metcalf Science Center, Boston University, SCI 518, 590 Commonwealth Avenue, Boston, MA 02215, USA; Department of Medicine, Metcalf Science Center, Boston University, SCI 518, 590 Commonwealth Avenue, Boston, MA 02215, USA.
Mark W
MW
Grinstaff
Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, 15 Francis St, Boston, MA 02115, USA; Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02155, USA. Electronic address: ycolson@partners.org.
Yolonda L
YL
Colson
D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D036103:Nanotechnology / Q000379:methods*; D013903:Thoracic Surgery / Q000379:methods*; D019616:Thoracic Surgical Procedures / Q000379:methods*
Lung cancer; Nanotechnology; Nanotheranostics; Thoracic surgery