GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.
There are many molecules that define regulatory T cells (Tregs) phenotypically and functionally. Glycoprotein A repetitions predominant (GARP) is a transmembrane protein containing leucine rich repeats. Recently, GARP is found to express highly on the surface of activated Tregs. The combination of GARP and other surface molecules isolates Tregs with higher purity. Besides, GARP is a cell surface molecule of Tregs that maintains their regulatory function and homeosatsis. GARP has also been proved to promote the activation and secretion of transforming growth factor β (TGF-β). Moreover, its potential value in cancer immunotherapy is also discussed in this work.
Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.
Liping
L
Sun
Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.
Hao
H
Jin
Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.
Hui
H
Li
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002462:Cell Membrane / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007167:Immunotherapy; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
D051858:Forkhead Transcription Factors; D006023:Glycoproteins; C087215:LRRC32 protein, human; D008565:Membrane Proteins; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1
glycoprotein A repetitions predominant; regulatory T cells; transforming growth factor β