Sympathetic neural-immune interactions regulate hematopoiesis, thermoregulation and inflammation in mammals.
This review will highlight recently discovered mechanisms underlying sympathetic nervous system (SNS) regulation of the immune system in hematopoiesis, thermogenesis, and inflammation. This work in mammals illuminates potential mechanisms by which the nervous and immune systems may interact in invertebrate and early vertebrate species and allow diverse organisms to thrive under varying and extreme conditions and ultimately improve survival.
Department of Biomedical Engineering, RC Box 270168, Goergen Hall, University of Rochester, Rochester, NY 14627, USA. Electronic address: kelley_madden@urmc.rochester.edu.
Kelley S
KS
Madden
D000818:Animals; D001833:Body Temperature Regulation; D006410:Hematopoiesis / Q000276:immunology; D006801:Humans; D007107:Immune System; D056747:Immunomodulation; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000502:physiology*; D008322:Mammals; D015213:Neuroimmunomodulation; D009638:Norepinephrine / Q000276:immunology; D013564:Sympathetic Nervous System / Q000276:immunology*
D009638:Norepinephrine
Hematopoiesis; Immune system; Inflammation; Norepinephrine; Sympathetic nervous system; Thermogenesis