Ghrelin and its correlation with leptin, energy related metabolites and thyroidal hormones in dairy cows in transitional period.
The transition from late gestation to early lactation is a critical period in a dairy cow's life so that dairy cows undergo tremendous changes during this period. The aim of this study was to determine blood levels of ghrelin, leptin, glucose, β-ydroxybutyrate (BHB), non-esterified fatty acids (NEFA), triglycerides (TG), triiodothyronine (T3) and thyroxine (T4) in dairy Holstein cows (n=20) and their correlations during the transition period. Blood samples were collected weekly from 3 wk antepartum to 6 wk postpartum from 20 high-yielding Holstein-Friesian cows. Ghrelin and leptin of plasma and glucose, BHB, NEFA, TG, T3, T4 of serum were then measured. Early lactation cows showed significantly higher (p<0.05) values of ghrelin, BHB and NEFA, and lower levels of leptin, TG, T3 and T4 (p<0.05) compared to late dry cows. Serum concentrations of glucose did not differ significantly at any time (P>0.05). Plasma ghrelin concentrations showed positive correlations with the serum BHB and NEFA (p<0.01), while plasma ghrelin had negative correlations (p<0.01) with leptin, TG, T3 and T4. In addition, no significant correlation (p>0.05) was found between ghrelin and glucose. The results of the study showed that blood ghrelin, leptin, BHB and NEFA levels are sensitive indicators of the energy balance during the peri-partum period in dairy cows and glucose values may not be considered as a precise indicator of negative energy balance in dairy cows.
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Nowroozi-Asl
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N
Aarabi
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Rowshan-Ghasrodashti
D020155:3-Hydroxybutyric Acid / Q000097:blood; D000818:Animals; D001786:Blood Glucose; D002417:Cattle / Q000097:blood / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D054439:Ghrelin / Q000097:blood*; D007774:Lactation / Q000502:physiology; D020738:Leptin / Q000097:blood*; D036801:Parturition; D013963:Thyroid Hormones / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D054439:Ghrelin; D020738:Leptin; D013963:Thyroid Hormones; D014280:Triglycerides; D020155:3-Hydroxybutyric Acid