Nickel-Catalyzed Stereoselective Dicarbofunctionalization of Alkynes.
A nickel-catalyzed three-component reaction involving terminal alkynes, boronic acids, and alkyl halides is presented herein. Trisubstituted alkenes can be obtained in a highly regio- and stereocontrolled manner by the simultaneous addition of both aryl and alkyl groups across the triple bond in a radical-mediated process. The reaction, devoid of air- and moisture-sensitive organometallic reagents and catalysts, is operationally simple and offers a broad scope and functional-group tolerance.
Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Zhaodong
Z
Li
Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Andrés
A
García-Domínguez
Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland. cristina.nevado@chem.uzh.ch.
Cristina
C
Nevado
alkyl halides; alkynes; boron; nickel; radicals