Mechanical and chemical implant decontamination in surgical peri-implantitis treatment: preclinical "in vivo" study.
The aim of the present study was to evaluate the effect of a titanium brush and chemical agents following surgical treatment of experimental peri-implantitis.



Six implants were installed in the mandible of eight beagle dogs (unit of analysis) 3 months after tooth extraction. Experimental peri-implantitis was induced 3 months later. The defects were randomly allocated in three treatment groups: (a) TiBrush(™)  + sodium hypochlorite + chlorhexidine (TBH), (b) TiBrush(™)  + chlorhexidine (TB), (c) an ultrasonic device + chlorhexidine (US). The distal implant in each hemimandible was used as control, and no treatment was done. Clinical and histological measurements were performed after 3 months of healing.



All treatment procedures resulted in statistically significant improvements of all clinical parameters. Histomorphometrical analysis revealed no statistically significant differences between treatment groups in terms of woven bone height (primary outcome). However, there were differences between test and control groups in terms of inflammation, bone defect depth and bone refill without differences between TBH and TB groups.



Resolution of peri-implantitis after access surgery and decontamination of peri-implant surfaces with TiBrush(™) with or without sodium hypochlorite is possible. However, the concomitant use of sodium hypochlorite has minor effect on treatment outcomes.
Periodontology Unit, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
Cristina
C
Carral
Department of Veterinary Clinical Sciences, University of Santiago de Compostela, Lugo, Spain.
Fernando
0000-0002-4130-1526
F
Muñoz
Department of Veterinary Clinical Sciences, University of Santiago de Compostela, Lugo, Spain.
María
M
Permuy
Periodontology Unit, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
Antonio
A
Liñares
Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York City, NY, USA.
Michel
M
Dard
Periodontology Unit, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
Juan
J
Blanco
D000818:Animals; D002710:Chlorhexidine; D003666:Decontamination; D015921:Dental Implants; D004285:Dogs; D057873:Peri-Implantitis; D014025:Titanium
D015921:Dental Implants; D014025:Titanium; D002710:Chlorhexidine
decontamination; experimental peri-implantitis; preclinical “in vivo” study; therapy