Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer.
OBJECTIVE
Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients.


METHODS
Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009.


RESULTS
In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022). In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates.


CONCLUSIONS
We suggested that TLE1 expression is a good prognostic indicator in GCs.
Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Ji-Hye
JH
Lee
Department of General Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Myoung-Won
MW
Son
Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Kyung-Ju
KJ
Kim
Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Mee-Hye
MH
Oh
Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea.
Hyundeuk
H
Cho
Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Hyun Ju
HJ
Lee
Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Si-Hyong
SH
Jang
Department of General Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Moon Soo
MS
Lee
Stomach neoplasms; Survival; TLE1; Tissue array analysis