Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents.
Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.


METHODS
Every discs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out.


RESULTS
Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity.


CONCLUSIONS
This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn't follow the fick's law. The water uptake and dissolution (DS), increased with the passing of time.
Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Shokouhsadat
S
Hamedi
Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza
MR
Shams-Ardakani
Herbal Medicine Department, Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran.
Omid
O
Sadeghpour
Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Gholamreza
G
Amin
Faculty of Traditional Medicine, Iran University of Medical Sciences, Tehran, Iran.
Dawood
D
Hajighasemali
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein
H
Orafai
Carbopol 934; Mucoadhesive discs; PVP(Polyvinylpyrrolidone); Pharmaceutical tests; Ziziphus jujuba stem bark