Evidence That Anorectal Transplantation Is the Logical Treatment for Serious Anorectal Dysfunction and Permanent Colostomy.
Anorectal dysfunction resulting in fecal incontinence or permanent colostomy is a current public health concern that strongly impairs patient quality of life. Present treatment options for this complex disease are expensive and usually ineffective. Anorectal transplantation is the logical treatment for fecal incontinence and permanent colostomy. This procedure has been clinically effective in a few cases reported in the medical literature. Furthermore, experiments in rats, pigs, and dogs have shown promising results, with functional recovery of the graft. In this article we describe the scientific evidence that anorectal transplantation may be an important option for treating anorectal dysfunction.
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil. Electronic address: fgalvao@usp.br.
F H
FH
Galvao
Department of Plastic Surgery, University of Tokyo, Tokyo, Japan.
J
J
Araki
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
V E
VE
Seid
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
D R
DR
Waisberg
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
M C
MC
Traldi
Department of Anatomy Aichi Medical University, Aichi, Japan.
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M
Naito
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
B C
BC
Araujo
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
C
C
Lanchotte
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
E
E
Chaib
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
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LA
D'Albuquerque
D000818:Animals; D003125:Colostomy; D004285:Dogs; D005242:Fecal Incontinence / Q000601:surgery*; D006801:Humans; D011788:Quality of Life; D051381:Rats; D020127:Recovery of Function; D012007:Rectum / Q000637:transplantation*; D013552:Swine