[Which animal models of nonalcoholic steatohepatitis-hepatocellular carcinoma (NASH-HCC) have more practical value in experimental investigations?].
In the past, we used to think that hepatocellular carcinoma (HCC) only occurred when nonalcoholic fatty liver disease (NAFLD) progressed to liver cirrhosis. However, recent clinical studies have shown that HCC may occur during the stage of nonalcoholic steatohepatitis (NASH). The prevalence of NAFLD and the increasing incidence of NASH-associated HCC require the elucidation of the pathogenesis of NASH-HCC and the assessment of the efficacy of novel therapies as early as possible, while these evaluations need reliable animal models. This article reviews the characteristics of NASH-HCC models with a practical value to uncover the mysteries of NASH-HCC.
Department of Medical Microbiology & Parasitology, Key Laboratory of Medical Molecular Virology, Fudan University School of Basic Medical Sciences, Shanghai 200032, China.
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Shanghai Institute of Liver Diseases, Fudan University, Shanghai 200032, China; Department of Medical Microbiology & Parasitology, Key Laboratory of Medical Molecular Virology, Fudan University School of Basic Medical Sciences, Shanghai 200032, China.
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D000818:Animals; D006528:Carcinoma, Hepatocellular; D005234:Fatty Liver; D006801:Humans; D008103:Liver Cirrhosis; D008113:Liver Neoplasms; D023421:Models, Animal; D065626:Non-alcoholic Fatty Liver Disease; D015995:Prevalence