Bad Ac-etylated Tau.
By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking.
Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jane C
JC
Hettinger
Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: cirritoj@neuro.wustl.edu.
John R
JR
Cirrito
D000544:Alzheimer Disease; D001921:Brain; D006801:Humans; D018091:Receptors, AMPA; D015398:Signal Transduction; D016875:tau Proteins
D018091:Receptors, AMPA; D016875:tau Proteins
Alzheimer’s disease; KIBRA; acetylation; post-translational modification; tau; tauopathy