Unravelling a new mechanism linking actin polymerization and gene transcription.
In the recent years, the role of actin and actin-binding proteins in gene transcription has received considerable attention. Nuclear monomeric and polymerized actin and several actin binding proteins have been detected in the mammalian cell nucleus, although their roles in transcription are just beginning to emerge. Our group recently reported that the actin-binding protein Filamin A interacts with the transcriptional coactivator MKL1 to link actin polymerization with transcriptional activity of Serum Response Factor. Here we summarize the regulation and function of MKL1, and highlight this novel mechanism of MKL1 regulation through binding to Filamin A and its implications for cell migration.
a Walther Straub Institute of Pharmacology and Toxicology , Ludwig-Maximilians-University , Munich , Germany.
Susanne
S
Muehlich
a Walther Straub Institute of Pharmacology and Toxicology , Ludwig-Maximilians-University , Munich , Germany.
Constanze
C
Hermanns
a Walther Straub Institute of Pharmacology and Toxicology , Ludwig-Maximilians-University , Munich , Germany.
Melanie A
MA
Meier
a Walther Straub Institute of Pharmacology and Toxicology , Ludwig-Maximilians-University , Munich , Germany.
Philipp
P
Kircher
a Walther Straub Institute of Pharmacology and Toxicology , Ludwig-Maximilians-University , Munich , Germany.
Thomas
T
Gudermann
D000199:Actins / Q000737:chemistry*; D000818:Animals; D002465:Cell Movement; D006801:Humans; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D015534:Trans-Activators / Q000378:metabolism; D014158:Transcription, Genetic
D000199:Actins; D015534:Trans-Activators
Filamin A; MAL; MKL1; MRTFA; SRF; actin