Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex.
Amyloid-β protein precursor (AβPP) is involved in synaptic formation and function. In the human cingulate cortex, AβPP was preferentially located in the presynaptic active zone as in rodents, indicating a preserved subsynaptic AβPP distribution across species and brain regions. Synaptic AβPP immunoreactivity was decreased with aging in cortical samples collected from autopsies of males (20-80 years), whereas the synaptic levels of α-secretase (ADAM10) and β-secretase (BACE1) did not significantly change. Decreased AβPP levels may be related to lower allostasis of synapses in the aged brain and their greater susceptibility to dysfunction characteristic of the onset of neurodegenerative disorders.
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.|FMUC - Faculty of Medicine, University of Coimbra, Portugal.
Anna
A
Pliássova
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.|FMUC - Faculty of Medicine, University of Coimbra, Portugal.
Paula M
PM
Canas
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.
Ana Carolina
AC
Xavier
Portuguese National Institute of Legal Medicine and Forensic Sciences (INMLCF IP), Coimbra, Portugal.
Beatriz S
BS
da Silva
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.|FMUC - Faculty of Medicine, University of Coimbra, Portugal.
Rodrigo A
RA
Cunha
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.|FMUC - Faculty of Medicine, University of Coimbra, Portugal.
Paula
P
Agostinho
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D053829:Amyloid Precursor Protein Secretases / Q000032:analysis* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000032:analysis* / Q000378:metabolism; D002540:Cerebral Cortex / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013569:Synapses / Q000737:chemistry*; D055815:Young Adult
D016564:Amyloid beta-Protein Precursor; D053829:Amyloid Precursor Protein Secretases
Aging; amyloid-β protein; human brain; sub-synaptic fractions; synapse; α-secretase; β-secretase