[Multiple and successive treatment failures in a patient infected by Plasmodium falciparum in Cambodia and treated by dihydroartemisinin-piperaquine].
Cases of treatment failures following administration of artemisinin-based combination therapies (ACT) remain rare in malaria endemic areas. In Cambodia, however, failures of these treatments are now commonly observed. Usually, these post-treatment recurrences occur only once and a second course of the same treatment is sufficient to cure patients.We describe here an atypical case of a Plasmodium falciparum-infected patient manifesting several malaria recrudescence episodes following dihydroartemisinin-piperaquine (Eurartesim®) treatment. This case report illustrates the current issue of resistance to the latest generation of antimalarial drugs in Southeast Asia and highlights the difficulty in efficaciously fighting malaria in this region if new therapy remains unimplemented.
Institut Pasteur du Cambodge, 5 boulevard Monivong, Phnom Penh, BP983, Cambodge. bwitkowski@pasteur-kh.org.
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Witkowski
Institut Pasteur du Cambodge, 5 boulevard Monivong, Phnom Penh, BP983, Cambodge.
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Khim
Institut Pasteur du Cambodge, 5 boulevard Monivong, Phnom Penh, BP983, Cambodge.
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Kim
Institut Pasteur du Cambodge, 5 boulevard Monivong, Phnom Penh, BP983, Cambodge.
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Domergue
Institut Pasteur du Cambodge, 5 boulevard Monivong, Phnom Penh, BP983, Cambodge.
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Duru
Institut Pasteur du Cambodge, 5 boulevard Monivong, Phnom Penh, BP983, Cambodge.
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Menard
D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins / Q000008:administration & dosage*; D002160:Cambodia; D004359:Drug Therapy, Combination; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum; D011804:Quinolines / Q000008:administration & dosage*; D012008:Recurrence; D017211:Treatment Failure; D010879:Piperazines
D000962:Antimalarials; D037621:Artemisinins; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines
ACT; Cambodia; Chemoresistance; Kachaun; Malaria; Plasmodium falciparum; Ratanakiri; South East Asia