Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study.
White matter (WM) alterations have been reported in methamphetamine (MA) users. However, knowledge about longitudinal changes in WM during abstinence from MA remains unknown. The present study aimed to examine how WM changes in long-term MA abstinent, in particular, whether the WM deficits would recover as the duration of abstinence extended. Twenty male MA dependent individuals and 19 healthy controls (HCs) were recruited and participated in both clinical assessments and diffusion tensor imaging (DTI) scans. The MA group underwent two DTI scans, a baseline scan with a duration of abstinence of 6.4 months and and a follow-up scan with a duration of abstinence of 13.0 months. Tract-Based Spatial Statistics was utilized to conduct baseline DTI analysis of MA group compared with HCs. The clusters with significant group differences of factional anisotropy (FA) were extracted as region of interests (ROIs). Mean values of DTI measurements (FA, mean diffusivity, axial diffusivity and radial diffusivity) were calculated within the ROIs in each subject's native space at baseline and follow-up. The MA group showed significant lower FA in the right internal capsule and superior corona radiate than HCs. The deficits did not recover when the duration of abstinence from MA reached 13 months. No significant correlations were found between FA and clinical measurements. Our results suggested persistent microstructure deficits of WM tracts surrounding the basal ganglia in MA dependent individuals.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People's Republic of China.
Wenxu
W
Zhuang
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People's Republic of China.
Yingying
Y
Tang
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People's Republic of China.
Na
N
Zhong
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People's Republic of China.
Haifeng
H
Jiang
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People's Republic of China.
Jiang
J
Du
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People's Republic of China. jijunwang27@gmail.com.
Jijun
J
Wang
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People's Republic of China. drminzhao@gmail.com.
Min
M
Zhao
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000628:therapy*; D002681:China / Q000453:epidemiology; D056324:Diffusion Tensor Imaging / Q000379:methods / Q000639:trends*; D005500:Follow-Up Studies; D006801:Humans; D020772:Internal Capsule / Q000000981:diagnostic imaging* / Q000187:drug effects*; D008137:Longitudinal Studies; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D010775:Photic Stimulation / Q000379:methods; D011897:Random Allocation; D057190:Stroop Test; D016320:Substance Abuse Treatment Centers / Q000379:methods / Q000639:trends; D013997:Time Factors
D008694:Methamphetamine
Basal ganglia; Diffusion tensor imaging; Longitudinal study; Methamphetamine dependence; White matter