The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review.
Antireflux therapy is incorporated in many treatment protocols for recurrent respiratory papillomatosis (RRP) because gastroesophageal reflux (GERD) is thought to worsen the disease course of RRP. It is unclear if GERD really aggravates the disease course. The aims of this systematic review were to 1) evaluate incidence of GERD among RRP patients and 2) report if GERD changes the clinical course or tissue properties of RRP.



A search was conducted in PubMed, Embase, and Google Scholar, following the methods of Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.



Articles with original data, published after January 1, 1990, on RRP with GERD as a determinant were eligible. There was no language restriction. Data on study design, study population, statistics, outcomes (incidence and influence of GERD), and risk of bias were collected and evaluated following PRISMA protocols.



Of 1,277 articles, 19 were selected. Gastroesophageal reflux was objectified in 25% to 100% of RRP patients. Subjective GERD was present in 0% to 70% of patients. There is no proof that GERD aggravated the clinical course or tissue properties of RRP, as measured by the number of surgeries, severity scoring systems, or dysplasia. One study did find a higher chance of web formation in patients with anterior or posterior glottic papillomas who did not receive antireflux therapy, but these results should be interpreted with care due to the study's quality.



There is insufficient proof that GERD does or does not aggravate the clinical course or tissue properties of RRP. Laryngoscope, 126:2330-2339, 2016.
Department of Otorhinolaryngology-Head & Neck Surgery, University Medical Center Groningen, Groningen, The Netherlands.|Graduate School of Medical Sciences (Cancer Research Center Groningen), University of Groningen, Groningen, The Netherlands.
Michel R M
MR
San Giorgi
Department of Otorhinolaryngology-Head & Neck Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Herman M
HM
Helder
Department of Otorhinolaryngology-Head & Neck Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Robbert-Jan S
RJ
Lindeman
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.|Graduate School of Medical Sciences (Cancer Research Center Groningen), University of Groningen, Groningen, The Netherlands.
Geertruida H
GH
de Bock
Department of Otorhinolaryngology-Head & Neck Surgery, University Medical Center Groningen, Groningen, The Netherlands. f.g.dikkers@umcg.nl.|Graduate School of Medical Sciences (Cancer Research Center Groningen), University of Groningen, Groningen, The Netherlands. f.g.dikkers@umcg.nl.
Frederik G
FG
Dikkers
D018450:Disease Progression; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology* / Q000628:therapy / Q000821:virology; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology; D012141:Respiratory Tract Infections / Q000150:complications* / Q000473:pathology; D012720:Severity of Illness Index
Gastroesophageal reflux disease; recurrent respiratory papillomatosis