Circulating interleukin-18: Association with IL-8, IL-10 and VEGF serum levels in patients with and without heart rhythm disorders.
BACKGROUND
An altered IL-18 pathway in patients with coronary artery disease has recently been described and this cytokine was shown to be of clinical and prognostic utility. Cardiomyocytes are a target of this cytokine which exerts inflammatory, hypertrophic and profibrotic activities.


OBJECTIVE
The aim of the study was to verify the ability of IL-18 to induce expression of other pro/anti-inflammatory cytokines and to analyse the relationship between these molecules in serum from patients with heart rhythm disorders and coronary artery disease.


METHODS
All patients in the study were divided into two groups: with heart rhythm disorders and without but with diagnosed coronary artery disease. Heart rhythm disorders included sinus node dysfunction, bradycardia and tachycardia.


RESULTS
The interrelationships among all tested clinical, biochemical and inflammatory parameters with a dependence on median IL-18 values were checked. From all tested parameters only cytokines IL-8, IL-10 and VEGF, were associated with the serum IL-18 levels.


CONCLUSIONS
IL-18, IL-8 and VEGF were identified as a factors involved in heart rhythm disorders and coronary artery disease patho-physiology and regarded as markers of prognostic significance and potential therapeutic targets. The demonstration of their in vivo relationship added new insights into the understanding of the interdependence of inflammatory pathways in patients with heart rhythm disorders or coronary artery disease.
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia. Electronic address: vmitrohin@gmail.com.
Mitrokhin
M
Vm
Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia; Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
Shim
S
Al
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
Aksyonov
A
Aa
Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
Zotov
Z
As
Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
Konev
K
Av
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
Ovchinnikov
O
Rs
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O.Box 162, 1000 Skopje, Macedonia. Electronic address: m.mitko@gmail.com.
Mladenov
M
Im
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
Kamkin
K
Ga
D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D020382:Interleukin-18 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D015415:Biomarkers; C508609:IL10 protein, human; C000589760:IL18 protein, human; D020382:Interleukin-18; D016209:Interleukin-8; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10
Coronary artery disease; Cytokines; Heart; Heart rhythm disorders; Interleukine-18