[Effect of specific immunotherapy on GM-CSF and IL-5 in the tissues of recurrent nasal polyps].
OBJECTIVE
To study the mechanism and clinical significance of specific immunotherapy (SIT) on the expression changes of GM-CSF and IL-5 in the tissue samples of recurrent nasal polyps.


METHODS
Perennial allergic rhinitis patients with recurrent nasal polyps were randomly divided into 2 groups. The experimental group of 19 patients was treated by SIT and standardized treatment (glucocorticoid nasal spray) , and the control group of 17 patients was only treated by standardized treatment (glucocorticoid nasal spray). We measured the expression levels of GM-CSF and IL-5 in the tissue samples of the nasal polyps by ELISA, and compared the results obtained before treatment with expression levels detected at 6 months and 1 year after the treatment.


RESULTS
The expression of GM-CSF and IL-5 in the recurrent nasal polyps reduced significantly (P < 0.05) in both groups after 6 months and 1 year post-treatment compared with pre-treatment, and the expression of GM-CSF and IL-5 in the experimental group was much lower than that of the control group.


CONCLUSIONS
SIT decreases the expression of GM-CSF and IL-5 and reduces the inflammatory reaction in the tissue samples of recurrent nasal polyps.
Jiefeng
J
Guo
Jiacheng
J
Feng
Lili
L
Lin
Xiaoming
X
Zhao
Huiqing
H
Wu
D004797:Enzyme-Linked Immunosorbent Assay; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation / Q000188:drug therapy; D015848:Interleukin-5 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000473:pathology; D009298:Nasal Polyps / Q000188:drug therapy* / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy / Q000378:metabolism
C508599:IL5 protein, human; D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor