Red Blood Cell Transfusion Strategies in Adult and Pediatric Patients with Malignancy.
Anemia in patients with malignancy is common as a consequence of their disease and treatment. Substantial progress has been made in the management of anemia with red blood cell transfusion in acute conditions, such as bleeding and infection, through the performance of large clinical trials. These trials suggest that transfusion at lower hemoglobin thresholds (restrictive transfusion ∼7-8 g/dL) is safe and in some cases superior to higher transfusion thresholds (liberal transfusion ∼9-10 g/dL). However, additional studies are needed in patients with malignancy to understand best practice in relation to quality of life as well as clinical outcomes.
Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA; Department of Laboratory Medicine, University of California, San Francisco, 270 Masonic Avenue, San Francisco, CA 94118, USA. Electronic address: Nareg.Roubinian@ucsf.edu.
Nareg
N
Roubinian
Research, Rutgers Robert Wood Johnson Medical School, Rutgers Biomedical and Health Sciences, Rutgers, The State University of New Jersey, 125 Paterson Street, New Brunswick, NJ 08901, USA.
Jeffrey L
JL
Carson
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D017707:Erythrocyte Transfusion; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006470:Hemorrhage / Q000097:blood / Q000209:etiology / Q000628:therapy; D006801:Humans; D007223:Infant; D007239:Infections / Q000097:blood / Q000209:etiology / Q000628:therapy; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000628:therapy; D011788:Quality of Life
D006454:Hemoglobins
Bleeding; Malignancy; RBC transfusion; Randomized clinical trials