Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans.
Lipidomics is the large-scale profiling and characterization of lipid species in a biological system using mass spectrometry. The skin barrier is mainly comprised of corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides, cholesterol and free fatty acids (FFA). Lipid compositions are altered in inflammatory skin disorders with disrupted skin barrier such as atopic dermatitis (AD).



Here we discuss some of the recent applications of lipidomics in human skin biology and in inflammatory skin diseases such as AD, psoriasis and Netherton syndrome. We also review applications of lipidomics in human skin equivalent and in pre-clinical animal models of skin diseases to gain insight into the pathogenesis of the skin disease. Expert commentary: Skin lipidomics analysis could be a fast, reliable and noninvasive tool to characterize the skin lipid profile and to monitor the progression of inflammatory skin diseases such as AD.
a Department of Pharmaceutical Sciences , College of Pharmacy, OSU-OHSU , Corvallis , OR , USA.
Shan
S
Li
a Department of Pharmaceutical Sciences , College of Pharmacy, OSU-OHSU , Corvallis , OR , USA.|b Molecular Cell Biology Program , OSU, Corvallis , OR , USA.
Gitali
G
Ganguli-Indra
a Department of Pharmaceutical Sciences , College of Pharmacy, OSU-OHSU , Corvallis , OR , USA.|b Molecular Cell Biology Program , OSU, Corvallis , OR , USA.|c Linus Pauling Science Institute, OSU , Corvallis , OR , USA.|d Department of Dermatology , Oregon Health & Science University , Portland , OR , USA.|e Knight Cancer Institute, OHSU , Portland , OR , USA.
Arup K
AK
Indra
D000818:Animals; D003872:Dermatitis / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D042241:Early Diagnosis; D004817:Epidermis / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000032:analysis*; D013058:Mass Spectrometry; D056770:Netherton Syndrome / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D011565:Psoriasis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology
D008055:Lipids
Netherton syndrome; Skin; atopic dermatitis; barrier; corneocytes; lipidomics; mass spectrometry; psoriasis