Morin Hydrate Mitigates Cisplatin-Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice.
Cisplatin is a widely used chemotherapeutic drug; however, it induces damage on kidney and liver at clinically effective higher doses. Morin hydrate possesses antioxidant, anti-inflammatory, and anticancer properties. Therefore, we aimed to investigate the effects of morin hydrate (50 and 100 mg/kg, orally) against the renohepatic toxicity induced by a high dose of cisplatin (20 mg/kg, intraperitoneally). Renal and hepatic function, oxidative/nitrosative stress, and inflammatory markers along with histopathology were evaluated. Morin hydrate ameliorated cisplatin-induced renohepatic toxicity significantly at 100 mg/kg as evidenced from the significant reversal of cisplatin-induced body weight loss, mortality, functional and structural alterations of kidney, and liver. The protective role offered by morin hydrate against cisplatin-induced renohepatic toxicity is by virtue of its free radical scavenging property, thereby abating the depletion of cellular antioxidant defense components and through modulation of inflammatory cytokines. We speculate morin hydrate as a protective candidate against renohepatic toxicity of cisplatin.
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781 032, India.
Athira
A
K V
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781 032, India.
Rajaram Mohanrao
RM
Madhana
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781 032, India.
Eshvendar Reddy
ER
Kasala
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781 032, India.
Pavan Kumar
PK
Samudrala
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781 032, India.|Department of Pharmacology, Gauhati Medical College, Guwahati, 781 032, India.
Mangala
M
Lahkar
Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Guwahati, 781 032, India.
Ranadeep
R
Gogoi
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004334:Drug Administration Schedule; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D015850:Interleukin-6 / Q000096:biosynthesis; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D015538:Nitrosation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D015431:Weight Loss / Q000187:drug effects; D000093242:Interleukin-6 Inhibitors; D047309:Flavones
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D002945:Cisplatin; D005419:Flavonoids; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C577686:interleukin-6, mouse; C008548:morin; D047309:Flavones
Cisplatin; Inflammation
; Morin Hydrate; Oxidative/nitrosative Stress; Toxicity