Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort.
We studied the association between specific congenital syndromes and autism spectrum disorders (ASD) in the large Finnish Register material. Our data include all children diagnosed with ASD (n = 4441) according to Finnish Hospital Discharge Register in 1987-2000. Four controls per each case were matched to sex, birthplace, date of birth (±30 days) and residence in Finland (n = 17,695). The prevalence of specific congenital syndromes in the Finnish Register of Congenital Malformations was evaluated among the ASD group and the controls by sex. The results of this study suggest that there is an association between several etiologically different syndromes and ASD when compared to controls without ASD. Statistically significant associations were observed with 47,XYY, Sotos syndrome, neurofibromatosis I, and syndrome not otherwise specified. Syndromes were more common among males with ASD compared to controls. These results support the previous studies of etiological heterogeneity of ASD and have importance in clinical examination, management and rehabilitation.
Department of Child Psychiatry, University of Turku and Turku University Hospital, Lemminkäisenkatu 3/Teutori, 20014, Turku, Finland. lamtim@utu.fi.|Department of Child Neurology, Helsinki University Hospital, Helsinki, Finland. lamtim@utu.fi.
Laura
L
Timonen-Soivio
Department of Child Neurology, Helsinki University Hospital, Helsinki, Finland.
Raija
R
Vanhala
Department of Child Psychiatry, University of Turku and Turku University Hospital, Lemminkäisenkatu 3/Teutori, 20014, Turku, Finland.|Teratology Information, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Heli
H
Malm
Department of Child Psychiatry, University of Turku and Turku University Hospital, Lemminkäisenkatu 3/Teutori, 20014, Turku, Finland.
Susanna
S
Hinkka-Yli-Salomäki
Department of Child Psychiatry, University of Turku and Turku University Hospital, Lemminkäisenkatu 3/Teutori, 20014, Turku, Finland.|National Institute for Health and Welfare, Helsinki, Finland.
Mika
M
Gissler
Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY, USA.
Alan
A
Brown
Department of Child Psychiatry, University of Turku and Turku University Hospital, Lemminkäisenkatu 3/Teutori, 20014, Turku, Finland.|Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Andre
A
Sourander
D000328:Adult; D001321:Autistic Disorder / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D009421:Nervous System Malformations / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D015995:Prevalence; D012042:Registries; D013577:Syndrome
Autism spectrum disorder; Chromosomal abnormalities; Single gene disorders; Syndromic autism