Location-dependent synaptic plasticity rules by dendritic spine cooperativity.
Nonlinear interactions between coactive synapses enable neurons to discriminate between spatiotemporal patterns of inputs. Using patterned postsynaptic stimulation by two-photon glutamate uncaging, here we investigate the sensitivity of synaptic Ca(2+) signalling and long-term plasticity in individual spines to coincident activity of nearby synapses. We find a proximodistally increasing gradient of nonlinear NMDA receptor (NMDAR)-mediated amplification of spine Ca(2+) signals by a few neighbouring coactive synapses along individual perisomatic dendrites. This synaptic cooperativity does not require dendritic spikes, but is correlated with dendritic Na(+) spike propagation strength. Furthermore, we show that repetitive synchronous subthreshold activation of small spine clusters produces input specific, NMDAR-dependent cooperative long-term potentiation at distal but not proximal dendritic locations. The sensitive synaptic cooperativity at distal dendritic compartments shown here may promote the formation of functional synaptic clusters, which in turn can facilitate active dendritic processing and storage of information encoded in spatiotemporal synaptic activity patterns.
Momentum Laboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, Budapest 1083, Hungary.
Jens P
JP
Weber
Momentum Laboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, Budapest 1083, Hungary.
Bertalan K
BK
Andrásfalvy
Momentum Laboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, Budapest 1083, Hungary.
Marina
M
Polito
Momentum Laboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, Budapest 1083, Hungary.
Ádám
Á
Magó
Momentum Laboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, Budapest 1083, Hungary.
Balázs B
BB
Ujfalussy
Momentum Laboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, Budapest 1083, Hungary.
Judit K
JK
Makara
D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D049229:Dendritic Spines / Q000502:physiology* / Q000648:ultrastructure; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D008867:Microtomy; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure; D046509:Tissue Culture Techniques
D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D012964:Sodium; D002118:Calcium