Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery.
We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China; Pharmacy College and College of Basic Science, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Xiangqian
X
Jia
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, China.
Weizhi
W
Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China; Pharmacy College and College of Basic Science, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Qiuju
Q
Han
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, China.
Zihua
Z
Wang
Pharmacy College and College of Basic Science, Liaoning Medical University, Jinzhou, Liaoning 121001, China; Pharmacy College and College of Basic Science, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Yunhong
Y
Jia
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, China.
Zhiyuan
Z
Hu
Antitumor; HER2; Nanocarrier; YLFFVFER