Long-Term Recurrence Rates of Peptic Ulcers without Helicobacter pylori.
OBJECTIVE
The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori.


METHODS
We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence.


RESULTS
Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, male, and comorbid chronic kidney disease.


CONCLUSIONS
The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, male, and comorbid chronic kidney disease.
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Jae Hyun
JH
Seo
Department of Internal Medicine, Digestive Disease Center and Research Institute, Soonchunhyang University College of Medicine, Bucheon, Korea.
Su Jin
SJ
Hong
Division of Gastroenterology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Jie-Hyun
JH
Kim
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Byung-Wook
BW
Kim
Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Sam Ryong
SR
Jee
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Woo Chul
WC
Chung
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Ki-Nam
KN
Shim
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
Gwang Ho
GH
Baik
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Sung Soo
SS
Kim
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sang Gyun
SG
Kim
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Jin Il
JI
Kim
D000328:Adult; D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D012008:Recurrence; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000382:microbiology; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors
D000900:Anti-Bacterial Agents
Helicobacter negative; Natural course; Peptic ulcer disease