Inherited renal carcinomas.
Hereditary forms of kidney carcinoma account for 5-8% of all malignant kidney neoplasms. The renal tumors are often multiple and bilateral and occur at an earlier age. Each of the hereditary kidney carcinoma syndromes is associated with specific gene mutations as well as a specific histologic type of kidney carcinoma. The presence of associated extrarenal manifestations may suggest a hereditary kidney cancer syndrome. Radiology is most commonly used to screen and manage patients with hereditary kidney cancer syndromes. This manuscript reviews the clinical and imaging findings of well-defined inherited kidney cancer syndromes including von Hippel-Lindau disease, Birt-Hogg-Dubé syndrome, hereditary papillary renal carcinoma syndrome, hereditary leiomyomatosis and RCC syndrome, tuberous sclerosis complex, and Lynch syndrome.
Departments of Radiology, Mayo Clinic in Scottsdale, AZ, 13400 E Shea Blvd., Scottsdale, AZ, 85259, USA. Kawashima.Akira@mayo.edu.
Akira
A
Kawashima
Departments of Radiology, Mayo Clinic in Scottsdale, AZ, 13400 E Shea Blvd., Scottsdale, AZ, 85259, USA.
Scott W
SW
Young
Departments of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Naoki
N
Takahashi
Departments of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Bernard F
BF
King
Departments of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Thomas D
TD
Atwell
D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000000981:diagnostic imaging* / Q000235:genetics*
Birt–Hogg–Dubé; Hereditary leiomyomatosis renal cell carcinoma; Hereditary papillary renal carcinoma; Inherited renal carcinomas; Lynch syndrome; Tuberous sclerosis complex; von Hippel–Lindau