LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes: association with adiposity.
We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (n = 40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6, SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation was also related to some metabolic alterations. CRP methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.
a Department of Nutrition and Health , Universidade Federal De Viçosa , Viçosa , Minas Gerais , Brazil ;
Júlia Cristina Cardoso
JC
Carraro
b Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research , University of Navarra, CIBERobn, Fisiopatología De La Obesidad Y La Nutrición, Institute of Health Carlos III , Pamplona , Madrid , Spain ;
Maria Luisa
ML
Mansego
b Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research , University of Navarra, CIBERobn, Fisiopatología De La Obesidad Y La Nutrición, Institute of Health Carlos III , Pamplona , Madrid , Spain ;
Fermin Ignacio
FI
Milagro
a Department of Nutrition and Health , Universidade Federal De Viçosa , Viçosa , Minas Gerais , Brazil ;
Larissa Oliveira
LO
Chaves
c Department of Nutrition , Universidade Federal De Alfenas , Alfenas , Minas Gerais , Brazil.
Fernanda Carvalho
FC
Vidigal
a Department of Nutrition and Health , Universidade Federal De Viçosa , Viçosa , Minas Gerais , Brazil ;
Josefina
J
Bressan
b Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research , University of Navarra, CIBERobn, Fisiopatología De La Obesidad Y La Nutrición, Institute of Health Carlos III , Pamplona , Madrid , Spain ;
J Alfredo
JA
Martínez
D050154:Adiposity / Q000235:genetics*; D015415:Biomarkers; D002352:Carrier Proteins / Q000235:genetics; D003430:Cross-Sectional Studies; D019175:DNA Methylation / Q000502:physiology*; D004032:Diet; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D020084:Long Interspersed Nucleotide Elements / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*
D015415:Biomarkers; D002352:Carrier Proteins; C508600:IL6 protein, human; D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human
Global DNA methylation; IL-6; SERPINE1; healthy eating index; metabolic syndrome