MYC - a thorn in the side of cancer immunity.
For decades, MYC has been known for its role in regulating cancer cell proliferation and survival. In a recent paper published in Science, Casey et al. have uncovered a new function for MYC in promoting immune evasion by directly regulating expression of programmed death-ligand 1 (PD-L1) and CD47 on cancer cells.
Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Stefani
S
Spranger
Department of Pathology, University of Chicago, Chicago, IL 60637, USA.|Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Thomas F
TF
Gajewski
Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Justin
J
Kline
D060890:B7-H1 Antigen; D051928:CD47 Antigen; D049109:Cell Proliferation; D006801:Humans; D007109:Immunity; D009369:Neoplasms
D060890:B7-H1 Antigen; D051928:CD47 Antigen