Chromosome organisation during ageing and senescence.
Acute cellular stress caused by oncogene activation or high levels of DNA damage can engage a tumour suppressive response, which can lead to cellular senescence. Chronic cellular stress evoked by low levels of DNA damage or telomere erosion is involved in the ageing process. In oncogene induced senescence in fibroblasts, a dramatic rearrangement of heterochromatin into foci and accumulation of constitutive heterochromatin is well documented. In contrast, a loss of heterochromatin has been described in replicative senescence and premature ageing syndromes. The distinct nuclear phenotypes that accompany the stress response highlight the differences between acute and chronic stress models, and this review will address the differences and similarities between these models with a focus on chromosome organisation and heterochromatin.
Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK. Electronic address: tamir.chandra@babraham.ac.uk.
Tamir
T
Chandra
Cambridge Institute for Medical Research, Wellcome Trust/MRC Stem Cell Institute and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK. Electronic address: kk429@cam.ac.uk.
Kristina
K
Kirschner
D000375:Aging / Q000473:pathology*; D000818:Animals; D002467:Cell Nucleus / Q000473:pathology*; D016922:Cellular Senescence; D002875:Chromosomes / Q000737:chemistry*; D004249:DNA Damage; D005347:Fibroblasts / Q000473:pathology; D006570:Heterochromatin; D006801:Humans; D011371:Progeria / Q000473:pathology*; D013312:Stress, Physiological
D006570:Heterochromatin