Septicemia with Streptococcus pseudopneumoniae: report of three cases with an apparent hepatic or bile duct association.
Streptococcus pseudopneumoniae was described in 2004 as a new human pathogen, acknowledged in a range of clinical infections typically associated to the respiratory tract. This report demonstrates that S. pseudopneumoniae has the potential to cause invasive infection. In blood cultures from three patients, growth of an atypical Streptococcus pneumoniae (non-capsular, non-serotypeable, optochin susceptible under ambient atmosphere and bile-intermediately soluble) was recovered. All three patients had a history of a haematological disease (myelodysplastic syndrome and multiple myeloma) and an apparent origin of infection related to the liver or bile duct. All isolates were genome sequenced and subsequently identified as S. pseudopneumoniae by multi-locus sequence analysis (MLSA). Multi-locus sequence typing (MLST) based on the S. pneumoniae scheme revealed unknown sequence types and the antibiogram and resistome revealed no antibiotic resistance.
a Department of Microbiology & Infection Control , Statens Serum Institut , Copenhagen , Denmark ;
Kurt
K
Fuursted
b Department of Clinical Microbiology , Hvidovre University Hospital , Hvidovre , Denmark ;
Pia Jeanette
PJ
Littauer
c Department of Clinical Microbiology , Aarhus University Hospital , Aarhus N , Denmark ;
Thomas
T
Greve
d Department of Biomedicine, Health , Aarhus University , Aarhus C , Denmark.
Christian F P
CF
Scholz
D000368:Aged; D000369:Aged, 80 and over; D001649:Bile Duct Diseases / Q000150:complications / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000150:complications / Q000382:microbiology; D018805:Sepsis / Q000150:complications / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics
Streptococcus pseudopneumoniae; hepatic and bile duct association; septicaemia; whole-genome sequencing