Increased Asymmetric Dimethylarginine and Ischemia-Modified Albumin Levels in Obstructive Sleep Apnea.
BACKGROUND
Asymmetric dimethylarginine and ischemia-modified albumin are new biomarkers that are used for evaluation of ischemia and oxidative stress. The present study aimed to investigate whether serum levels of asymmetric dimethylarginine and ischemia-modified albumin are altered in subjects with obstructive sleep apnea (OSA).


METHODS
A cross-sectional, clinical study was implemented on data derived from 79 subjects who underwent polysomnography. Cases were allocated into 3 groups with respect to polysomnography results: Group 1 consisted of 22 subjects without apnea, whereas Group 2 comprised 29 subjects with mild to moderate OSA, and Group 3 included 28 subjects with severe OSA. These 3 groups were compared in terms of demographic datas and polysomnographic parameters, serum levels of asymmetric dimethylarginine and ischemia-modified albumin.


RESULTS
Serum levels of ischemia-modified albumin were significantly higher in Groups 2 and 3 (P = .001). Mean SpO2 of Group 3 was notably lower than that of Groups 1 and 2 (P < .001), whereas times for SpO2 <90% were statistically significantly different from each other in all 3 groups (P < .001). Serum levels of asymmetric dimethylarginine in Group 3 were notably higher than those in Group 1 (P = .027). Levels of ischemia-modified albumin were correlated positively with AHI and time SpO2 <90% values (P = .008 and P < .001, respectively).


CONCLUSIONS
Ischemia-modified albumin and asymmetric dimethylarginine were significantly higher in subjects with OSA. Furthermore, ischemia-modified albumin was independently associated with severity of OSA defined by AHI and severity of oxygen desaturation.
Department of Chest Diseases izciaysel@mynet.com.
Aysel
A
Sunnetcioglu
Department of Chest Diseases.
Selvi
S
Asker
Department of Biochemistry, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
Hamit Hakan
HH
Alp
Department of Chest Diseases.
Hulya
H
Gunbatar
D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood*
D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; C018524:N,N-dimethylarginine; D001120:Arginine; D000075462:Serum Albumin, Human
asymmetric dimethylarginine; ischemia modified albumin; obstructive sleep apnea