Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption.
Primary adult-type lactose malabsorption (PALM) is a widespread inherited autosomal recessive condition, which is considered to be associated with osteoporosis. This prospective study aimed at assessing the 25-hydroxy-vitamin D (25(OH)D) status and serum CrossLaps levels in individuals with PALM and normal controls.



All participants (n=210) underwent genotyping for the LCT C/T-13910 polymorphism, 25(OH)D and CrossLaps measurements and clinical examinations. In addition, the anthropometric data (that is, height, weight and body mass index) were determined.



Fifty-five individuals with PALM (that is, LCT C/C-13910 homozygotes) showed lower 25(OH)D (mean: 24.95±10.04 vs 28.59±9.56 ng/ml, P=0.018) and higher CrossLaps serum levels (mean: 0.46±0.31 vs 0.43±0.49 ng/ml, P=0.251) compared with 155 normal controls (that is, LCT C/T-13910 hetero- or T/T-13910 homozygotes). Anthropometric data were similar between PALM probands and controls.



Individuals with PALM were found to have lower 25(OH)D and higher CrossLaps serum levels compared with normal controls. In order to preserve life-long bone health, routine 25(OH)D and CrossLaps serum measurements should be performed in individuals with PALM.
Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria.
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Enko
Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria.
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Kriegshäuser
Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria.
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Stolba
Clinical Institute of Medical and Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
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Mangge
University of Applied Sciences for Health Professions Upper Austria, Bachelor Programme Biomedical Science, General Hospital Steyr, Steyr, Austria.
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Brandstetter
University of Applied Sciences for Health Professions Upper Austria, Bachelor Programme Dietetics, General Hospital Elisabethinen Linz, Linz, Austria.
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Mayr
Department of Applied Systems Research and Statistics, Johannes Kepler University Linz, Linz, Austria.
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Forstner
Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria.
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Halwachs-Baumann
D000328:Adult; D015992:Body Mass Index; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D005838:Genotype; D006801:Humans; D007408:Intestinal Absorption; D043322:Lactase / Q000097:blood / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D007785:Lactose / Q000378:metabolism*; D007787:Lactose Intolerance / Q000097:blood / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology / Q000235:genetics; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*; D014815:Vitamins / Q000097:blood; D055815:Young Adult
D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D014815:Vitamins; C052929:collagen type I trimeric cross-linked peptide; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; D014807:Vitamin D; D003094:Collagen; C104450:25-hydroxyvitamin D; D043322:Lactase; D007785:Lactose