Structural Analysis Using Chiroptical Spectroscopy: Insights and Cautions.
Chiroptical spectroscopy has evolved into a promising tool for chiral molecular structural determination in the last four decades. Determination of the absolute configurations (ACs) of bromochlorofluoromethane and [(2) H1 ,(2) H2 ,(2) H3 ]-neopentane demonstrated the enviable advantages of chiroptical spectroscopy. Furthermore, uncovering the errors in the ACs reported in the literature established a glimpse of what can be accomplished with the modern chiroptical spectroscopic methods. Despite these triumphs, it is important to exercise caution in the practice of chiroptical spectroscopic methods, because certain widely practiced approaches can lead to erroneous conclusions. Selected major accomplishments and special precautions needed for future applications are emphasized. Chirality 28:445-452, 2016. © 2016 Wiley Periodicals, Inc.
Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Prasad L
PL
Polavarapu
D002942:Circular Dichroism / Q000379:methods*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D007530:Isoflurane / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010420:Pentanes / Q000737:chemistry; D011789:Quantum Theory; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013237:Stereoisomerism
D006846:Hydrocarbons, Halogenated; D010420:Pentanes; C424690:bromochlorofluoromethane; D007530:Isoflurane; C039752:neopentane
circular dichroism; optical activity; specific rotation; spectroscopy; vibrational