Massive inflammatory reaction following the removal of a ruptured silicone implant masking the invasive breast cancer - case report and literature review.
This paper presents a case of a patient with invasive ductal breast cancer following breast augmentation. Following breast implants rupture in March 2013 the breast implants have been removed - histopathological examination revealed leaked silicone with inflammatory infiltration, without evidence of cancerous lesions. Diagnostic imaging revealed multiple encapsulated silicone particles and clusters of post-inflammatory macrocalcifications in both breasts. In January 2014 the patient presented with symptoms of massive inflammation of the left breast. Following surgical consultation the patient had undergone radical left-sided mastectomy with lymphadenectomy. Postoperative histopathological examination revealed a multifocal advanced invasive ductal cancer G3 pT3pN3a (vascular invasion, metastases in 11 of 12 examined axillary lymph nodes). Following surgery the patient was qualified for further treatment - chemotherapy, radiotherapy, hormone therapy. The discussion includes a review of literature on the risk evaluation of co-occurrence of breast cancers in women with silicone breast implants and presents diagnostic challenges of breast cancer in this patient group.
Piotr
P
Nowaczyk
Aleksandra
A
Budnicka
Mateusz
M
Wichtowski
Paweł
P
Kurzawa
Dawid
D
Murawa
D000368:Aged; D019928:Breast Implantation / Q000009:adverse effects; D018427:Breast Implants / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D008206:Lymphatic Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D015412:Mastectomy, Segmental / Q000379:methods; D011475:Prosthesis Failure; D020034:Silicone Gels / Q000009:adverse effects*
D020034:Silicone Gels