Parental physical and lifestyle factors and their association with newborn body composition.
OBJECTIVE
To investigate the parental physical and lifestyle determinants of newborn body composition.


METHODS
Prospective cohort study.


METHODS
Cork University Maternity Hospital, a tertiary referral hospital in Cork, Ireland.


METHODS
All babies were recruited as part of a prospective birth cohort, Babies After


METHODS
Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE). These babies were recruited from women who had participated in the Screening of Pregnancy Endpoints (SCOPE) study Ireland, a prospective, multicentre cohort study


METHODS
Multivariate linear regression was used to analyse the effect of a range of maternal and paternal physical and lifestyle features on neonatal body fat percentage (BF%).


METHODS
Neonatal BF%. Neonatal adiposity was assessed within 48 hours of birth using air displacement plethysmography (PEAPOD(®) ).


RESULTS
In all, 1243 infants were enrolled in the study. Increasing maternal body mass index (adjusted mean difference 0.09; 0.04, 0.15) and waist height ratio (adjusted mean difference 6.59; 0.27, 12.92) were significantly associated with increased neonatal BF%. In contrast, maternal smoking was associated with reduced neonatal BF% compared with non smokers (adjusted mean difference -0.55; -1.07, -0.03). Infant sex significantly altered neonatal BF%, with female infants having higher neonatal BF% compared with male infants (adjusted mean difference 1.98; 1.54, 2.53). No association was observed between paternal body mass index (BMI), paternal age or paternal smoking and neonatal BF%.


CONCLUSIONS
Maternal smoking, BMI, waist height ratio and infant sex were associated with altered BF%.


CONCLUSIONS
Maternal smoking, BMI, waist height ratio and infant sex are associated with altered neonatal body fat percentage.
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland. fergus.mccarthy@kcl.ac.uk.|Division of Women's Health KCL, Women's Health Academic Centre KHP, St Thomas's Hospital, London, UK. fergus.mccarthy@kcl.ac.uk.
F P
FP
McCarthy
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland.|Department of Epidemiology and Public Health, University College Cork, Cork, Ireland.
A S
AS
Khashan
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland.|Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
D
D
Murray
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland.|Department of Food Science and Nutrition, University College Cork, Cork, Ireland.
M
M
Kiely
Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
J O'B
JO
Hourihane
Division of Women's Health KCL, Women's Health Academic Centre KHP, St Thomas's Hospital, London, UK.
D
D
Pasupathy
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland.
L C
LC
Kenny
D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D005220:Fathers / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007494:Ireland; D008019:Life Style; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D009035:Mothers / Q000706:statistics & numerical data*; D015999:Multivariate Analysis; D010991:Plethysmography / Q000379:methods; D011446:Prospective Studies; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D065927:Waist-Height Ratio; D055815:Young Adult
Body fat composition; lifestyle determinants; newborn body composition; smoking