Bleomycin induced flagellate erythema in a patient with thalamic mixed germ cell tumour: Report of a rare adverse effect.
Bleomycin induced flagellate dermatitis is an uncommon and unique adverse effect. With the declining use of bleomycin, this complication is becoming increasingly infrequent in day-to-day clinical practice. We herein describe a case of a 13year old male patient with left thalamic mixed germ cell tumour treated by multimodality approach, who developed flagellate erythema after two cycles of combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). This brief report highlights the importance of awareness and timely identification and management of this dermatological toxicity in patients undergoing bleomycin based combination chemotherapy.
Department of Radiotherapy and Oncology, All India Institute of Medical Sciences, New Delhi, India. Electronic address: dr_ahitagni@yahoo.co.in.
Ahitagni
A
Biswas
Department of Radiotherapy and Oncology, All India Institute of Medical Sciences, New Delhi, India.
Pramod Kumar
PK
Julka
D000293:Adolescent; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001623:Betamethasone / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects* / Q000627:therapeutic use; D017332:Cetirizine / Q000627:therapeutic use; D064146:Chemotherapy-Induced Febrile Neutropenia; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D061888:Craniospinal Irradiation; D004890:Erythema / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D005047:Etoposide / Q000009:adverse effects / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging / Q000628:therapy*; D015173:Supratentorial Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D013788:Thalamus
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D005047:Etoposide; D001623:Betamethasone; D002945:Cisplatin; D017332:Cetirizine
Bleomycin; Dermatitis; Erythema; Flagellate