Hypophosphataemia due to FGF-23 producing B cell non-Hodgkin's lymphoma.
Oncogenic osteomalacia (or tumour-induced osteomalacia) is a rare paraneoplastic syndrome caused by overproduction of fibroblastic growth factor 23 (FGF-23) by tumours. Excessive production of FGF-23 can lead to severe, symptomatic hypophosphataemia. The majority of cases have been associated with benign tumours of bone or soft tissue, such as haemangiopericytomas or other neoplasms of mesenchymal origin. We present a case of a 68-year-old woman with an FGF-23 producing B cell non-Hodgkin's lymphoma. Treatment with immunochemotherapy resulted in normalisation of serum FGF-23 and phosphate levels.
Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands.
Jan H
JH
Elderman
Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands.
Marike
M
Wabbijn
Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands.
Felix
F
de Jongh
D000368:Aged; D001402:B-Lymphocytes; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D017674:Hypophosphatemia / Q000097:blood / Q000209:etiology*; D016393:Lymphoma, B-Cell / Q000097:blood / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin; D009372:Neoplasms, Connective Tissue / Q000097:blood / Q000209:etiology*; D010018:Osteomalacia / Q000097:blood / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000097:blood*
C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23