title: Two endogenous retroviral loci appear to contribute to Multiple Sclerosis.
abstract: BACKGROUND
  Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).
  
  
  RESULTS
  The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.
  
  
  CONCLUSIONS
  We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.
authors.affiliation: Aarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark. nexo@biomed.au.dk.
authors.forename: Bjørn A
authors.initials: BA
authors.lastname: Nexø
authors.affiliation: Aarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark.
authors.forename: Sara B
authors.initials: SB
authors.lastname: Jensen
authors.affiliation: Aarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark.|Present address: VIA University College, DK-8200, Aarhus, Denmark.
authors.forename: Kari K
authors.initials: KK
authors.lastname: Nissen
authors.affiliation: Aarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark.
authors.forename: Bettina
authors.initials: B
authors.lastname: Hansen
authors.affiliation: Department of Clinical Medicine, Aarhus University, DK-8000, Aarhus C, Denmark.|Department of Rheumatology, Aarhus University Hospital, DK-8000, Aarhus C, Denmark.
authors.forename: Magdalena J
authors.initials: MJ
authors.lastname: Laska
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D020077:Endogenous Retroviruses / Q000235:genetics*; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*
keywords: Endogenous retroviral loci; Multiple sclerosis; Rheumatoid arthritis; Synergy of viruses; Type 1 Diabetes