title: Chemokine CXCL13 concentration in cerebrospinal fluid in patients with neuroborreliosis--own observations.
abstract: OBJECTIVE
  of the study was to evaluate the usefulness of cerebrospinal fluid chemokine CXCL13 concentration assay in diagnostics of neuroborreliosis in adults.
  
  
  METHODS
  Investigations were carried out in 22 patients treated for neuroborreliosis , manifested as lymphocytic meningitis, at the Department of Infectious Diseases, Medical University of Silesia, in Bytom between 2011-2013. Based on the presence or absence of anti-borrelial antibodies in the cerebrospinal fluid, the examined individuals were divided into two groups on the day of admission: group I--patients with antiborrelial antibodies in the cerebrospinal fluid (confirmed diagnosis of neuroborreliosis), group II--patients without antiborrelial antibodies in the cerebrospinal fluid (possible diagnosis of neuroborreliosis). In all patients the cerebrospinal fluid CXCL13 level was assessed on the first day of hospitalization. Control tests were performed in both groups after 14 days of therapy with antibiotics.
  
  
  RESULTS
  Mean cerebrospinal fluid CXCL13 concentration in group I on the 1st day was 4123 pg/mL, and in group II--3422 pg/mL. Differences in mean concentrations of this chemokine were statistically insignificant. No correlations between examined mean CXCL13 concentrations and other cerebrospinal fluid inflammatory parameters were revealed. The control tests showed the evident decrease of CXCL13 level in cerebrospinal fluid in both groups. Besides, in individuals of group II anti-Borrelia burgdorferi antibodies appeared in cerebrospinal fluid, whereas in group I, the control results of this parameter were similar to preliminary values.
  
  
  CONCLUSIONS
  The obtained results indicate a kind of usefulness of estimation of cerebrospinal fluid chemokine CXCL13 concentration in diagnostics of early, acute neuroborreliosis, manifested as lymphocytic meningitis, especially in case of anti-borrelia antibodies absence in cerebrospinal fluid. Changes in this chemokine concentrations, opposite to cerebrospinal fluid levels of anti-borrelia antibodies, may be prognostic in acute, early neuroborreliosis.
authors.affiliation: Medical University of Silesia, School of Medicine with Division of Dentistry, Chair and Clinical Ward of Infectious Diseases in Bytom.
authors.forename: Lucjan
authors.initials: L
authors.lastname: Kępa
authors.affiliation: Medical University of Silesia, School of Medicine with Division of Dentistry, Chair and Clinical Ward of Infectious Diseases in Bytom.
authors.forename: Barbara
authors.initials: B
authors.lastname: Oczko-Grzesik
authors.affiliation: Medical University of Silesia, School of Medicine with Division of Dentistry, Chair and Clinical Ward of Infectious Diseases in Bytom.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sobala-Szczygieł
authors.affiliation: Medical University of Silesia, School of Medicine with Division of Dentistry, Chair and Clinical Ward of Infectious Diseases in Bytom.
authors.forename: Anna
authors.initials: A
authors.lastname: Boroń-Kaczmarska
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000502:physiology*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D054382:Chemokine CXCL13 / Q000134:cerebrospinal fluid*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D020852:Lyme Neuroborreliosis / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; C110663:CXCL13 protein, human; D054382:Chemokine CXCL13