title: Quadruple Cancers of Non-producing Multiple Myeloma, Cholangiocellular Carcinoma, and Two Different Thyroid Cancers.
abstract: We report the case of a 72-year-old man who presented with non-producing multiple myeloma (MM) with three additional concomitant solid tumors that were identified by postmortem autopsy. The disease was refractory to anti-MM therapy including bortezomib and lenalidomide, and he finally died of bacterial pneumonia with diffuse alveolar damage 8 months after the diagnosis. An autopsy revealed that he was also affected by three other solid cancers, cholangiocellular carcinoma, medullary thyroid cancer and papillary thyroid cancer that were clinically asymptomatic and remained undiagnosed before death. A review of the literature suggests that primary quadruple cancers including MM are extremely rare.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Mizutani
authors.forename: Junya
authors.initials: J
authors.lastname: Kuroda
authors.forename: Nana
authors.initials: N
authors.lastname: Sasaki
authors.forename: Miki
authors.initials: M
authors.lastname: Kiyota
authors.forename: Shotaro
authors.initials: S
authors.lastname: Tatekawa
authors.forename: Taku
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Saori
authors.initials: S
authors.lastname: Maegawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Chinen
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimura
authors.forename: Hisao
authors.initials: H
authors.lastname: Nagoshi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horiike
authors.forename: So
authors.initials: S
authors.lastname: Tando
authors.forename: Shinji
authors.initials: S
authors.lastname: Fushiki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications*; D000069286:Bortezomib / Q000627:therapeutic use; D002277:Carcinoma / Q000150:complications*; D018278:Carcinoma, Neuroendocrine / Q000150:complications*; D002291:Carcinoma, Papillary; D018281:Cholangiocarcinoma / Q000150:complications*; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D013792:Thalidomide / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology
chemical_list: D013792:Thalidomide; D000069286:Bortezomib; D000077269:Lenalidomide