title: The interleukin 6 c.-174 CC genotype is a predictor for new cardiovascular events in patients with coronary heart disease within three years follow-up.
abstract: The main aim of this study was to evaluate putative associations between the interleukin (IL)-6 c.-174G>C polymorphism (rs 1800795) and the cardiovascular outcome (combined endpoint: myocardial infarction, stroke/TIA, cardiac death, death according to stroke) among patients with coronary heart disease (CHD) within three years follow-up. Overall 942 in-patients with CHD were included. The drop-out rate was 4.9%. The IL-6 polymorphism was determined with PCR-SSP. Kaplan-Meier plots with Log Rank test and Cox regression were used as statistically procedures. The IL-6 CC genotype was associated with a higher incidence of the combined endpoint (25.0% versus 13.5%, p<0.001) and an increased Hazard Ratio (HR 2.165, 95% CI 1.516-3.092, p<0.001) adjusted for established cofactors for CHD. This result suggests that the IL-6 -174 polymorphism is a putative independent risk indicator for new cardiovascular events among patients with CHD.
authors.affiliation: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany. Electronic address: stefan.reichert@uk-halle.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Reichert
authors.affiliation: Department of Cardiology, Paracelsus-Harz-Clinic Bad Suderode, Quedlinburg, Germany; Department of Internal Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin-Luther-University Halle-Wittenberg, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Schlitt
authors.affiliation: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
authors.forename: Ann-Christin
authors.initials: AC
authors.lastname: Benten
authors.affiliation: Department of Cardiothoracic Surgery, Heart Centre of the University Clinics Halle (Saale), Martin-Luther-University Halle-Wittenberg, Germany.
authors.forename: Britt
authors.initials: B
authors.lastname: Hofmann
authors.affiliation: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
authors.forename: Hans-Günter
authors.initials: HG
authors.lastname: Schaller
authors.affiliation: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schulz
mesh_terms: D003327:Coronary Disease / Q000150:complications / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D011401:Promoter Regions, Genetic; D020521:Stroke / Q000209:etiology / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Coronary heart disease; Gene polymorphism; Interleukin-6; New cardiovascular events