title: Metabolic changes in overweight and obese women above 35 years using Ethinylestradiol/drosperinone combined contraceptive pills: a 3-year case-control study.
abstract: OBJECTIVE
  To assess metabolic changes in overweight and obese women above 35 years using ethinylestradiol/drosperinone combined contraceptive pills for 36 cycles.
  
  
  METHODS
  A prospective case-control study over 3 years recruiting 202 overweight and obese women above the age of 35 years who were divided into two groups, study group (n = 90) who received Ethinylestradiol/drospirenone for 36 cycles, and control group (n = 112) to whom intrauterine device was inserted. Recording of the body weight, waist circumference, blood pressure, fasting blood glucose and fasting blood lipids including triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol before starting the method and repeated at 12, 24 and 36 cycles of use.
  
  
  RESULTS
  No significant change was observed in body weight, waist circumference, blood pressure and fasting blood glucose between the two groups (p > 0.05).There was a significant reduction in triglycerides, total and LDL cholesterol with elevation in HDL cholesterol in the study group after 24 and 36 cycles of use (p < 0.05).
  
  
  CONCLUSIONS
  Ethinylestradiol/drospirenone combined contraceptive pills do not alter blood pressure or affect the body weight, with favorable effects on blood lipids in overweight and obese women above the age of 35 years when used for 24-36 cycles.
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rezk
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Tarek
authors.initials: T
authors.lastname: Sayyed
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Hamid
authors.initials: H
authors.lastname: Ellakwa
authors.affiliation: b Department of Internal Medicine , and.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Zahran
authors.affiliation: c Department of Cardiology , Faculty of Medicine, Menoufia University , Menoufia , Egypt.
authors.forename: Awni
authors.initials: A
authors.lastname: Gamal
mesh_terms: D000328:Adult; D000736:Androstenes / Q000008:administration & dosage / Q000494:pharmacology*; D016022:Case-Control Studies; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood / Q000188:drug therapy; D050177:Overweight / Q000097:blood* / Q000188:drug therapy; D011446:Prospective Studies; D012102:Reproductive Control Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000736:Androstenes; D012102:Reproductive Control Agents; C534342:drospirenone and ethinyl estradiol combination; D004997:Ethinyl Estradiol
keywords: Blood lipids; ethinylestradiol/drospirenone; obese women