title: Traumatic Endotheliopathy: A Prospective Observational Study of 424 Severely Injured Patients.
abstract: Investigate and confirm the association between sympathoadrenal activation, endotheliopathy and poor outcome in trauma patients.
  
  
  
  The association between sympathoadrenal activation, endotheliopathy, and poor outcome in trauma has only been demonstrated in smaller patient cohorts and animal models but needs confirmation in a large independent patient cohort.
  
  
  
  Prospective observational study of 424 trauma patients admitted to a level 1 Trauma Center. Admission plasma levels of catecholamines (adrenaline, noradrenaline) and biomarkers reflecting endothelial damage (syndecan-1, thrombomodulin, and sE-selectin) were measured and demography, injury type and severity, physiology, treatment, and mortality up till 28 days were recorded.
  
  
  
  Patients had a median ISS of 17 with 72% suffering from blunt injury. Adrenaline and noradrenaline correlated with syndecan-1 (r = 0.38, P < 0.001 and r = 0.23, P < 0.001, respectively) but adrenaline was the only independent predictor of syndecan-1 by multiple linear regression adjusted for age, injury severity score, Glascow Coma Scale, systolic blood pressure, base excess, platelet count, hemoglobin, prehospital plasma, and prehospital fluids (100 pg/mL higher adrenaline predicted 2.75 ng/mL higher syndecan-1, P < 0.001). By Cox analyses adjusted for age, sex, injury severity score, Glascow Coma Scale, base excess, platelet count and hemoglobin, adrenaline, and syndecan-1 were the only independent predictors of both <24-hours, 7-day and 28-day mortality (all P < 0.05). Furthermore, noradrenaline was an independent predictor of <24-hours mortality and thrombomodulin was an independent predictor of 7-day and 28-day mortality (all P < 0.05).
  
  
  
  We confirmed that sympathoadrenal activation was strongly and independently associated with endothelial glycocalyx and cell damage (ie, endotheliopathy) and furthermore that sympathoadrenal activation and endotheliopathy were independent predictors of mortality in trauma patients.
authors.affiliation: *Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark †Department of Surgery, Centre for Translational Injury Research, UT Health, University of Texas Health Science Center at Houston, Houston, TX ‡Department of Anesthesia, Centre of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Pär I
authors.initials: PI
authors.lastname: Johansson
authors.forename: Hanne H
authors.initials: HH
authors.lastname: Henriksen
authors.forename: Jakob
authors.initials: J
authors.lastname: Stensballe
authors.forename: Mikkel
authors.initials: M
authors.lastname: Gybel-Brask
authors.forename: Jessica C
authors.initials: JC
authors.lastname: Cardenas
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Baer
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Cotton
authors.forename: John B
authors.initials: JB
authors.lastname: Holcomb
authors.forename: Charles E
authors.initials: CE
authors.lastname: Wade
authors.forename: Sisse R
authors.initials: SR
authors.lastname: Ostrowski
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002395:Catecholamines / Q000097:blood*; D015331:Cohort Studies; D019040:E-Selectin / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009638:Norepinephrine / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016019:Survival Analysis; D053668:Syndecan-1 / Q000097:blood*; D018180:Thrombomodulin / Q000097:blood; D014193:Trauma Centers; D014947:Wounds and Injuries / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy
chemical_list: D015415:Biomarkers; D002395:Catecholamines; D019040:E-Selectin; D053668:Syndecan-1; D018180:Thrombomodulin; D009638:Norepinephrine; D004837:Epinephrine