title: New therapy, new challenges: The effects of long-term continuous flow left ventricular assist device on inflammation.
abstract: Surgically implanted continuous flow left ventricular assist devices (CF-LVADs) are currently used in patients with end-stage heart failure (HF). However, CF-LVAD therapy introduces a new set of complications and adverse events in these patients. Major adverse events with the CF-LVAD include right heart failure, vascular dysfunction, stroke, hepatic failure, and multi-organ failure, complications that may have inflammation as a common etiology. Our aim was to review the current evidence showing a relationship between these adverse events and elevated levels of inflammatory biomarkers in CF-LVAD recipients.
authors.affiliation: Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Canada. Electronic address: Liza.Grosman-Rimon@uhn.ca.
authors.forename: Liza
authors.initials: L
authors.lastname: Grosman-Rimon
authors.affiliation: Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Canada.
authors.forename: Filio
authors.initials: F
authors.lastname: Billia
authors.affiliation: Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Canada.
authors.forename: Avi
authors.initials: A
authors.lastname: Fuks
authors.affiliation: Faculty of Kinesiology and Physical Education, University of Toronto, Canada.
authors.forename: Ira
authors.initials: I
authors.lastname: Jacobs
authors.affiliation: Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: A McDonald
authors.affiliation: Division of Nephrology, University Health Network, University of Toronto, Canada.
authors.forename: David Z
authors.initials: DZ
authors.lastname: Cherney
authors.affiliation: Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Canada. Electronic address: Vivek.Rao@uhn.ca.
authors.forename: Vivek
authors.initials: V
authors.lastname: Rao
mesh_terms: D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery*; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000150:complications; D009102:Multiple Organ Failure / Q000209:etiology; D051437:Renal Insufficiency / Q000209:etiology; D020521:Stroke / Q000209:etiology
keywords: Continuous flow left ventricular assist devices (CF-LVADs); Heart failure (HF) inflammatory biomarkers