title: [THROMBOGENIC RISK FACTORS IN PATIENTS WITH EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE].
abstract: We studied activation of hemostatic reactions together with mechanisms of systemic inflammation and genetic factors responsible for thrombogenic risk in 65 patients suffering exacerbation of chronic obstructive pulmonary disease with 2 or 3 positive criteria proposed by N.Anthonisen at al. (1987). The levels of indicators of systemic inflammation, such as C-reactive protein and tumour necrosis factor-alpha, increased concurrently with those of homocysteine, endothelin-1, Willebrand factor plasminogen activator inhibitor type 1, and thrombin-antithrombin complex (marker of thrombinemia). The prevalence of pathological alleles ofprotein genes involved in the hemostasis system and folate cycle remained as in the control group. A relationship between plasma levels of thrombin-antithrombin complex and Willebrand factor and the activity of indicators of systemic inflammation was documented. Treatment of exacerbation resulted in the decrease in the levels of the thrombin- antithrombin complex, inhibitor of the extrinsic pathway of coagulation, and plasminogen activator inhibitor type 1. The treatment failed to normalize parameters of thrombinemia and blood fibrinolytic potential.
authors.forename: A G
authors.initials: AG
authors.lastname: Chuchalin
authors.forename: I Ya
authors.initials: IY
authors.lastname: Tseimakh
authors.forename: A R
authors.initials: AR
authors.lastname: Momot
authors.forename: A N
authors.initials: AN
authors.lastname: Mamaev
authors.forename: I A
authors.initials: IA
authors.lastname: Karbyshev
authors.forename: L A
authors.initials: LA
authors.lastname: Strozenko
mesh_terms: D000368:Aged; D000990:Antithrombin III; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood*; D012307:Risk Factors
chemical_list: C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases