title: Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine.
abstract: The prospect of changing the plasticity of terminally differentiated cells toward pluripotency has completely altered the outlook for biomedical research. Human-induced pluripotent stem cells (iPSCs) provide a new source of therapeutic cells free from the ethical issues or immune barriers of human embryonic stem cells. iPSCs also confer considerable advantages over conventional methods of studying human diseases. Since its advent, iPSC technology has expanded with 3 major applications: disease modeling, regenerative therapy, and drug discovery. Here we discuss, in a comprehensive manner, the recent advances in iPSC technology in relation to basic, clinical, and population health.
authors.affiliation: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, California. Electronic address: sayedns@stanford.edu.
authors.forename: Nazish
authors.initials: N
authors.lastname: Sayed
authors.affiliation: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, California.
authors.forename: Chun
authors.initials: C
authors.lastname: Liu
authors.affiliation: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, California. Electronic address: joewu@stanford.edu.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
mesh_terms: D002318:Cardiovascular Diseases / Q000628:therapy; D054338:Cell Transdifferentiation; D055808:Drug Discovery; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D008954:Models, Biological; D010597:Pharmacogenetics; D057285:Precision Medicine; D044968:Regenerative Medicine; D023822:Tissue Engineering; D057170:Translational Research, Biomedical
keywords: drug discovery; human-induced pluripotent stem cells; macromedicine; micromedicine; personalized medicine