title: Image segmentation with a novel regularized composite shape prior based on surrogate study.
abstract: OBJECTIVE
  Incorporating training into image segmentation is a good approach to achieve additional robustness. This work aims to develop an effective strategy to utilize shape prior knowledge, so that the segmentation label evolution can be driven toward the desired global optimum.
  
  
  METHODS
  In the variational image segmentation framework, a regularization for the composite shape prior is designed to incorporate the geometric relevance of individual training data to the target, which is inferred by an image-based surrogate relevance metric. Specifically, this regularization is imposed on the linear weights of composite shapes and serves as a hyperprior. The overall problem is formulated in a unified optimization setting and a variational block-descent algorithm is derived.
  
  
  RESULTS
  The performance of the proposed scheme is assessed in both corpus callosum segmentation from an MR image set and clavicle segmentation based on CT images. The resulted shape composition provides a proper preference for the geometrically relevant training data. A paired Wilcoxon signed rank test demonstrates statistically significant improvement of image segmentation accuracy, when compared to multiatlas label fusion method and three other benchmark active contour schemes.
  
  
  CONCLUSIONS
  This work has developed a novel composite shape prior regularization, which achieves superior segmentation performance than typical benchmark schemes.
authors.affiliation: The Department of Radiation Oncology, University of California, Los Angeles, California 90095.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: The Department of Radiation Oncology, University of California, Los Angeles, California 90095.
authors.forename: Dan
authors.initials: D
authors.lastname: Ruan
mesh_terms: D000465:Algorithms; D001271:Atlases as Topic; D002968:Clavicle / Q000000981:diagnostic imaging; D003337:Corpus Callosum / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods