title: The effect of 5-aminosalicylic acid on renal ischemia-reperfusion injury in rats.
abstract: OBJECTIVE
  Ischemia-reperfusion (IR) contributes to the development acute renal failure. Oxygen free radicals are involved in the pathophysiology of IR injury (IRI). This study was designed to investigate the effects of 5-aminosalicylic acid (5-ASA), which is known antioxidant agent, in IR-induced renal injury in rats.
  
  
  METHODS
  Male Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 24 h of reperfusion. 5-ASA (300 mg/kg, i.p) was administered prior to ischemia. After 24 h reperfusion, urine and blood samples were collected for the determination of creatinine (Cr) and nitric oxide (NO) levels, and renal samples were taken for the histological evaluation.
  
  
  RESULTS
  Treatment with 5-ASA significantly decreased serum Cr and NO levels, also significantly increased urinary Cr level and decreased histopathological changes induced by IR.
  
  
  CONCLUSIONS
  Treatment with 5-ASA had a beneficial effect on renal IRI. These results may indicate that 5-ASA exerts nephroprotective effects in renal IRI.
authors.affiliation: Department of Physiology, Ardabil University of Medical Sciences, Ardabil, Iran.
authors.forename: Shokofeh
authors.initials: S
authors.lastname: Banaei
mesh_terms: D000818:Animals; D007668:Kidney / Q000098:blood supply*; D007677:Kidney Function Tests; D008297:Male; D019804:Mesalamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D019804:Mesalamine
keywords: 5-aminosalicylic acid; antioxidant; nitric oxide; renal ischemia-reperfusion