title: Pathology and Quality of Life Outcomes Following Office-based Transperineal Prostate Biopsy.
abstract: OBJECTIVE
  To report the incidence of prostate cancer diagnosis and quality of life outcomes following transperineal prostate biopsy.
  
  
  METHODS
  Forty-six consecutive patients underwent office-based transperineal prostate biopsy for an elevated prostate-specific antigen and a normal digital rectal examination without prior prostate biopsy. Prior to biopsy, a repeat prostate-specific antigen was obtained to ensure persistent elevation. Silodosin (8 mg daily) was initiated the day prior to biopsy and continued for 1 week. A total of 18-20 biopsy cores were obtained per patient. All patients responded to a visual analog scale ranging from 0 to 10 immediately following the completion of both the local anesthesia and the biopsy procedure. In addition, an International Prostate Symptom Score (IPSS), Rectal Function Assessment Score, International Index of Erectile Function, Center for Epidemiologic Studies Depression Scale, and postvoid residual were obtained at baseline and 30 days following biopsy, except IPSS which was also obtained at day 7.
  
  
  RESULTS
  The mean patient age was 63.3 years with a mean prostate volume of 41.8 cm(3). The mean visual analog scale was 4.2 for the local anesthesia and 3.0 for the biopsy. Thirty-one patients (67.4%) were diagnosed with prostate cancer, with 18 having a Gleason score ≥ 7. Compared to baseline, no adverse changes in IPSS, Rectal Function Assessment Score, International Index of Erectile Function, Center for Epidemiologic Studies Depression Scale, or postvoid residual were detected at day 30. No patient required catheterization, developed sepsis, or required hospitalization.
  
  
  CONCLUSIONS
  Office-based transperineal prostate biopsy was well tolerated with reasonable treatment-related discomfort, a high rate of prostate cancer diagnosis, and the absence of significant morbidity including sepsis.
authors.affiliation: Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV; Department of Urology, Wheeling Hospital, Wheeling, WV. Electronic address: gmerrick@urologicresearchinstitute.org.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Merrick
authors.affiliation: Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV.
authors.forename: Sarah
authors.initials: S
authors.lastname: Irvin
authors.affiliation: Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV.
authors.forename: Ryan
authors.initials: R
authors.lastname: Fiano
authors.affiliation: Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV.
authors.forename: Richard
authors.initials: R
authors.lastname: Anderson
authors.affiliation: Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV.
authors.forename: Wayne M
authors.initials: WM
authors.lastname: Butler
authors.affiliation: Department of Pathology, Wheeling Hospital, Wheeling, WV.
authors.forename: Edward
authors.initials: E
authors.lastname: Adamovich
mesh_terms: D062005:Biopsy, Large-Core Needle / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010502:Perineum; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D011788:Quality of Life