title: Procarcinogenic regulatory T cells in microbial-induced colon cancer.
abstract: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.
authors.affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University , Baltimore, MD, USA.
authors.forename: Abby L
authors.initials: AL
authors.lastname: Geis
authors.affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University , Baltimore, MD, USA.
authors.forename: Franck
authors.initials: F
authors.lastname: Housseau
keywords: Carcinogenesis; Enterotoxigenic Bacteroides fragilis; IL-17; inflammation; Microbiome