title: Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios.
abstract: Targeting delivery system use natural drugs for tumor cells is an appealing platform help to reduce the side effects and enhance the therapeutic effects of the drug. In this study, we synthesized curcumin (Cur) loaded (D, L Poly lactic - Poly ethylenglycol) micelle (Cur/PLA-PEG) with the ratio of PLA/PEG of 3:1 2:1 1:1 1:2 and 1:3 (w/w) and another micelle modified by folate (Cur/PLA-PEG-Fol) for targeting cancer therapy. The PLA-PEG copolymer was synthesized by ring opening polymerization method. After loading onto the micelle, solubility of Cur increased from 0.38 to 0.73mgml(-1). The average size of prepared Cur/PLA-PEG micelles was from 60 to 69nm (corresponding to the ratio difference of PLA/PEG) and the drug encapsulating efficiency was from 48.8 to 91.3%. Compared with the Cur/PLA-PEG micelles, the size of Cur/PLA-PEG-Fol micelles were from 80 to 86nm and showed better in vitro cellular uptake and cytotoxicity towards HepG2 cells. The cytotoxicity of the NPs however depends much on the PEG component. The results demonstrated that Folate-modified micelles could serve as a potential nano carrier to improve solubility, anti-cancer activity of Cur and targeting ability of the system.
authors.affiliation: Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Ha Noi City, Vietnam; University of Khanh Hoa, 01 Nguyen Chanh Road, Nha Trang City, Khanh Hoa Province, Vietnam.
authors.forename: Quoc Thong
authors.initials: QT
authors.lastname: Phan
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Ha Noi City, Vietnam.
authors.forename: Mai Huong
authors.initials: MH
authors.lastname: Le
authors.affiliation: Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Ha Noi City, Vietnam.
authors.forename: Thi Thu Huong
authors.initials: TT
authors.lastname: Le
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Ha Noi City, Vietnam.
authors.forename: Thi Hong Ha
authors.initials: TH
authors.lastname: Tran
authors.affiliation: Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Ha Noi City, Vietnam.
authors.forename: Phuc Nguyen
authors.initials: PN
authors.lastname: Xuan
authors.affiliation: Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Ha Noi City, Vietnam. Electronic address: thuhp@ims.vast.ac.vn.
authors.forename: Phuong Thu
authors.initials: PT
authors.lastname: Ha
mesh_terms: D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D065546:Drug Liberation; D005492:Folic Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D012995:Solubility / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D008823:Micelles; C542623:monomethoxypolyethyleneglycol-polylactide block copolymer; D011092:Polyethylene Glycols; D005492:Folic Acid; D003474:Curcumin
keywords: Curcumin (Cur); PLA-PEG copolymer; PLA-PEG/Cur; PLA-PEG/Cur/Fol