title: Metolazone Associated Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap.
abstract: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe mucocutaneous disease with high mortality rate. It is characterised by severe necrosis and detachment of the epidermis. Drugs are the most common triggering agent for SJS/TEN. These are commonly reported with the use of aromatic antiepileptics, antiretrovirals, allopurinol, NSAID'S and sulfonamide antibiotics. Non antibiotic sulfonamides rarely cause SJS/TEN. Metolazone is a well known diuretic and is extensively used by clinicians. Although this drug is in market for last several decades, no case of SJS/TEN has been reported till date. We report a rare case of metolazone induced SJS/TEN overlap in a 55-year-old lady.
authors.affiliation: Senior Resident, Department of Medicine, PGIMER & Dr RML Hospital , New Delhi, India .
authors.forename: Prabhat
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Associate Professor, Department of Medicine PGIMER & Dr RML Hospital , New Delhi, India .
authors.forename: Ajay
authors.initials: A
authors.lastname: Chauhan
authors.affiliation: Postgraduate Resident, Department of Medicine PGIMER & Dr RML Hospital , New Delhi, India .
authors.forename: Riyaz
authors.initials: R
authors.lastname: Charaniya
authors.affiliation: Postgraduate Resident, Department of Medicine PGIMER & Dr RML Hospital , New Delhi, India .
authors.forename: Anindya
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Postgraduate Resident, Department of Medicine PGIMER & Dr RML Hospital , New Delhi, India .
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Tandon
keywords: Naranjo Probability Scale; SCORTEN score; Thiazide diuretic