title: Risk of obesity and metabolic syndrome associated with FTO gene variants discloses clinically relevant gender difference among Turks.
abstract: Gene variations in the fat mass- and obesity-associated gene (FTO) have shown controversial associations with obesity and metabolic syndrome (MetS) in several populations. We explored the association of FTO gene with obesity, MetS, and insulin-related parameters separately in men and women. Two SNPs in the FTO, gene rs9939609 and rs1421085, were genotyped by the Taqman System in 1967 adults (mean age of the whole group 50.1 ± 12.0; 48.4 % male). A random sample of the Turkish Adult Risk Factor cohort was cross-sectionally analyzed. Both SNPs exhibited strong linkage disequilibrium (r(2) = 0.85) and minor alleles were associated with risk of obesity in women and of MetS in men. Carriers of the rs1421085 C-allele exhibited higher body mass index (BMI) in each gender. Adjusted fasting insulin and HOMA index were significantly higher in C-allele carriers in men alone. Logistic regression analysis demonstrated significantly increased likelihood for obesity in female C-risk allele carriers (OR 1.61; 95 % CI 1.19-2.18), after adjustment for age, smoking status, alcohol usage, physical activity grade and presence of diabetes mellitus. Male C-allele carriers were at increased risk for MetS (OR 1.44; 95 % CI 1.07-1.95), adjusted for age, smoking status, alcohol consumption, and physical activity. Further adjustment for BMI attenuated the MetS risk, indicating interaction between C-allele, gender and BMI. The FTO gene in Turkish adults contributes independently to obesity in women and-by interacting with BMI-to MetS and insulin resistance in men.
authors.affiliation: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Vakıf Gureba Cad, Sehremini, 34080, Istanbul, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Guclu-Geyik
authors.affiliation: Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Altan
authors.initials: A
authors.lastname: Onat
authors.affiliation: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Vakıf Gureba Cad, Sehremini, 34080, Istanbul, Turkey.
authors.forename: Ayse Berna
authors.initials: AB
authors.lastname: Yuzbasıogulları
authors.affiliation: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Vakıf Gureba Cad, Sehremini, 34080, Istanbul, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Coban
authors.affiliation: Department of Public Health, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Gunay
authors.initials: G
authors.lastname: Can
authors.affiliation: Department of Clinical Chemistry, School of Medicine, Fimlab Laboratories and University of Tampere, 33521, Tampere, Finland.
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.affiliation: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Vakıf Gureba Cad, Sehremini, 34080, Istanbul, Turkey. nihanerginel@yahoo.com.
authors.forename: Nihan
authors.initials: N
authors.lastname: Erginel-Unaltuna
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012727:Sex Characteristics; D017678:Sex Distribution; D014421:Turkey / Q000453:epidemiology
chemical_list: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Abdominal obesity; FTO gene polymorphism; Gender difference; Metabolic syndrome; Obesity; Turkish Adult Risk Factor Study