title: Electromyographic studies regarding denervation potentials in skeletal muscles at sites near and distant from the burn in rats.
abstract: Changes in membrane AChRs in skeletal muscles located near or distant from burn injury similar to denervated muscles may make electrodiagnostic features indistinguishable from true neuropathic changes. The aim of this study was to examine electrodiagnostic changes of muscles at sites local and distant from the burn after thermal injuries due to neuromuscular junction dysfunction. A total of 40 adult male rats were randomly allocated to four groups. Rats in group 1 received thermal burn injury over gastrocnemius muscle of one leg and sham burn on the other leg. A 20-25% and 30-35% surface body area burn and also 30-35% surface body area sham burn were produced at distant site from gastrocnemius muscle in group 2, 3 and 4, respectively. To explore any fibrillation potential, the rats underwent serial electromyographic studies of bilateral gastrocnemius muscles over 5 weeks after burn injury. There were no denervation potentials either in muscles at sites distant from 20-25% and 30-35% of total body surface area burns or in muscles beneath the burn. In the present study on rats, thermal burn injury could not make fibrillation potentials in the electrodiagnostic study of muscles located near and distant from the burn site.
authors.affiliation: a Burn Research Center , Iran University of Medical Sciences , Tehran , Iran, Republic of Islamic.
authors.forename: Simin
authors.initials: S
authors.lastname: Sajadi
authors.affiliation: a Burn Research Center , Iran University of Medical Sciences , Tehran , Iran, Republic of Islamic.
authors.forename: Korosh
authors.initials: K
authors.lastname: Mansoori
authors.affiliation: a Burn Research Center , Iran University of Medical Sciences , Tehran , Iran, Republic of Islamic.
authors.forename: Bijan
authors.initials: B
authors.lastname: Forogh
authors.affiliation: a Burn Research Center , Iran University of Medical Sciences , Tehran , Iran, Republic of Islamic.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Fatemi
authors.affiliation: a Burn Research Center , Iran University of Medical Sciences , Tehran , Iran, Republic of Islamic.
authors.forename: Tannaz
authors.initials: T
authors.lastname: Ahadi
authors.affiliation: a Burn Research Center , Iran University of Medical Sciences , Tehran , Iran, Republic of Islamic.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Chahardoli Razji
mesh_terms: D000818:Animals; D002056:Burns / Q000473:pathology*; D004195:Disease Models, Animal; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D007839:Functional Laterality; D008297:Male; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
keywords: Burn injury; Denervation; Electromyographic study; Fibrillation potential; Membrane acetylcholine receptors; Skeletal muscles