title: Selective Serotonin Re-uptake Inhibitors (SSRIs) Induced Weight Changes: A Dose and Duration Dependent Study on Albino Rats.
abstract: BACKGROUND
  Selective Serotonin Re-uptake Inhibitors (SSRIs) are the most significant and safe drugs among the antidepressants. Fluoxetine is the prototype drug of SSRIs. Various clinical studies showed that SSRI causes change in body weight in patients. This study was conducted to know the extent of weight change with different doses for different durations.
  
  
  OBJECTIVE
  The aim of this study was to find out whether fluoxetine causes weight gain or weight loss, and to deduce the comparative weight change after intraperitoneal injection of fluoxetine for different duration and doses.
  
  
  METHODS
  Present study was conducted on 72 adult (36 males and 36 females) albino rats, in 3 phases of 2 weeks, 4 weeks and 12 weeks duration. Each phase consisted of 24 (12 males and 12 females) albino rats. These 24 rats were further randomly subdivided into 4 Groups of 6 albino rats each (3 males & 3 females). Group 1(Control) received normal saline (vehicle). Rest 18 rats of each phase were experimental rats, of Group 2, Group 3 and Group 4 (6 rats each). Group 2, group 3 and group 4 experimental rats received 10mg/kg, 20 mg/kg and 40mg/kg of intraperitoneal injection of fluoxetine respectively. All rats were weighed on each day for growth monitoring. Data was subjected to statistical analysis (Mean, standard deviation and Student's t-Test).
  
  
  RESULTS
  All experimental group rats which received fluoxetine showed decrease of body weight. Rats which received high doses of fluoxetine could not tolerate the drug for more than two weeks and died due to excessive body weight loss, loose stools and muscle twitching.
  
  
  CONCLUSIONS
  Present study conclude that SSRIs can cause weight change in the form of decrease of body weight. This property of SSRIs can be used clinically by prescribing these drugs to obese psychiatric patient without any fear of withdrawal of drug.
authors.affiliation: Assistant Professor, Department of Anatomy, HIMS, SRHU , Jolly Grant, Dehradun, India .
authors.forename: Alka
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Professor and Head, Department of Anatomy, HIMS, SRHU , Jolly Grant, Dehradun, India .
authors.forename: S L
authors.initials: SL
authors.lastname: Jethani
authors.affiliation: Professor, Department of Anatomy, HIMS, SRHU , Jolly Grant, Dehradun, India .
authors.forename: R K
authors.initials: RK
authors.lastname: Rohatgi
authors.affiliation: Professor, Department of Pharmacology, HIMS, SRHU , Jolly Grant, Dehradun, India .
authors.forename: Juhi
authors.initials: J
authors.lastname: Kalra
keywords: Anorexia; Fluoxetine; Hypothalamo-pituitary axis; Serotonin receptor; Weight loss