title: Aortic pulsatility assessed by an oscillometric method is associated with coronary atherosclerosis in elderly people.
abstract: The aim of this study was to investigate the association of aortic pulsatility assessed by a non-invasive brachial cuff-based method with coronary atherosclerosis. In total, 139 patients undergoing coronary angiography were included in this cross-sectional study. Aortic blood pressure (BP) indices were recorded invasively by a fluid-filled catheter and non-invasively by a brachial cuff-based oscillometric device. Fractional pulse pressure (FPP) was defined as pulse pressure (PP)/mean BP and pulsatility index (PI) as PP/diastolic BP. Aortic FPP and PI in coronary artery disease (CAD) patients were significantly higher than in non-CAD patients in both invasive and non-invasive methods. Multivariate logistic regression analysis demonstrated that non-invasively measured aortic FPP and PI were associated with CAD risk in patients aged ≥70 years [aortic FPP per 0.1 odds ratio (OR) = 1.66, 95% confidence interval (CI) 1.05-2.64; aortic PI per 0.1 OR =1.39, 95% CI 1.02-1.88; all p < 0.05], but were not associated with CAD risk in patients aged <70 years. In linear regression analysis, non-invasively measured aortic FPP and PI correlated with SYNTAX and Gensini scores only in patients aged ≥70 years. Aortic FPP and PI measured non-invasively by a brachial cuff-based oscillometric device were associated with coronary atherosclerosis in elderly patients.
authors.affiliation: a Department of Cardiovascular Medicine , Chiba University Graduate School of Medicine , Chiba , Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakagomi
authors.affiliation: a Department of Cardiovascular Medicine , Chiba University Graduate School of Medicine , Chiba , Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Okada
authors.affiliation: a Department of Cardiovascular Medicine , Chiba University Graduate School of Medicine , Chiba , Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shoji
authors.affiliation: a Department of Cardiovascular Medicine , Chiba University Graduate School of Medicine , Chiba , Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D001011:Aorta; D001794:Blood Pressure; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension
keywords: Ageing arterial stiffness; central blood pressure; coronary artery disease; pulsatility