title: Evaluation of bone morphogenic proteins in periodontal practice.
abstract: Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.
authors.affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.
authors.forename: Supreet
authors.initials: S
authors.lastname: Kaur
authors.affiliation: Department of Periodontics, National Dental College and Hospital, Dera Bassi, Punjab, India.
authors.forename: Vishakha
authors.initials: V
authors.lastname: Grover
authors.affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.
authors.forename: Harkiran
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Department of Periodontics, National Dental College and Hospital, Dera Bassi, Punjab, India.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Malhotra
keywords: Bone morphogenetic protein; growth factors; periodontal regeneration