title: Magistral drugs in hospitalized newborns and children.
abstract: OBJECTIVE
  Study the use of magistral oral solutions and suspensions in infants and children at a university hospital.
  
  
  METHODS
  This is a descriptive study based on the analysis of the assessed hospital's magistral drug request forms regarding the patients in the neonatal ICU, Obstetrics, Pediatrics and Pediatric Emergency from January 2012 to December 2013. The frequency of drug requests and dispensation was evaluated and the consumption of each active ingredient of the preparations was expressed as number of "infant defined daily dose" (iDDD) and of iDDD/100 bed-days.
  
  
  RESULTS
  A total of 657 forms were analyzed - a monthly average of 27 pediatric preparations. The neonatal ICU accounted for 69.6% of these requests. Twenty-one drug items were used, of which the most common were folinic acid (88 requests), sulfadiazine (85) and captopril (73). The consumption of the active principle in these preparations varied in number of iDDD, from 7.5 (hydralazine) to 16,520.0 (folic acid), and in number of iDDD/100 bed-days in the neonatal ICU, from 0.1 (zinc sulfate) to 146.1 (folic acid).
  
  
  CONCLUSIONS
  The constant consumption of magistral oral solutions and suspensions by newborns and children of the assessed hospital indicates the need for such preparations as a pediatric therapeutic alternative in this hospital.
authors.affiliation: Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil.
authors.forename: Agueda Cabral de Souza
authors.initials: AC
authors.lastname: Pereira
authors.affiliation: Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil.
authors.forename: Elaine Silva
authors.initials: ES
authors.lastname: Miranda
authors.affiliation: Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil.
authors.forename: Selma Rodrigues de
authors.initials: SR
authors.lastname: Castilho
authors.affiliation: Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil.
authors.forename: Débora Omena
authors.initials: DO
authors.lastname: Futuro
authors.affiliation: Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil.
authors.forename: Lenise Arneiro
authors.initials: LA
authors.lastname: Teixeira
authors.affiliation: Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil. Electronic address: geraldopaula@vm.uff.br.
authors.forename: Geraldo Renato de
authors.initials: GR
authors.lastname: Paula
mesh_terms: D000284:Administration, Oral; D002648:Child; D004339:Drug Compounding; D006760:Hospitalization; D006785:Hospitals, University; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D055553:Prescription Drugs / Q000627:therapeutic use*; D012189:Retrospective Studies; D012996:Solutions / Q000627:therapeutic use; D013535:Suspensions / Q000627:therapeutic use
chemical_list: D055553:Prescription Drugs; D012996:Solutions; D013535:Suspensions
keywords: Fractionated drugs; Medicamentos fracionados; Medicamentos não licenciados; Medicamentos pediátricos; Medication use; Pediatric medications; Unlicensed drugs; Uso de medicamentos