title: Impact of maternal serum levels of Visfatin, AFP, PAPP-A, sFlt-1 and PlGF at 11-13 weeks gestation on small for gestational age births.
abstract: OBJECTIVE
  Investigating potential value of maternal serum Visfatin, sFlt-1, PlGF, AFP, PAPP-A levels at first trimester for prediction of small for gestational age (SGA) at birth.
  
  
  METHODS
  Measurements were performed in 20 SGA and 65 control cases. Logistic regression analysis adjusted for age and weeks of pregnancy at data collection was performed to estimate odds ratios (OR), 95% confidence intervals (95% CI) and p values separately for each potential predictor. A multiple regression model was used to assess the impact of all the promising predictors adjusted for each other. Receiver operating characteristic (ROC) analysis was used to indicate the ability to discriminate between SGA cases and controls.
  
  
  RESULTS
  There was an association of serum PlGF levels (OR 0.53 per interquartile range [IQR] increase in PlGF; 95% CI 0.24-1.16), sFlt-1/PlGF ratio (OR 1.42 per IQR increase in sFlt-1/PlGF; 95% CI 1.03-1.96), serum Visfatin levels (OR 0.31 per IQR increase in Visfatin; 95% CI 0.10-0.95) and smoking (OR 4.24; 95% CI 1.10-16.37) with SGA at birth.
  
  
  CONCLUSIONS
  Associations between SGA and lower PlGF, Visfatin levels as well as increased sFlt-1/PlGF ratio and smoking status were detected which may contribute to predict SGA.
authors.affiliation: a Department of Obstetrics and Gynecology , University Hospital of Essen , Essen , Germany.
authors.forename: Cahit
authors.initials: C
authors.lastname: Birdir
authors.affiliation: a Department of Obstetrics and Gynecology , University Hospital of Essen , Essen , Germany.
authors.forename: Janina
authors.initials: J
authors.lastname: Fryze
authors.affiliation: b Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen , Essen , Germany , and.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Frölich
authors.affiliation: c Department of Obstetrics and Gynecology , Sana Kliniken Duisburg , Duisburg , Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Schmidt
authors.affiliation: a Department of Obstetrics and Gynecology , University Hospital of Essen , Essen , Germany.
authors.forename: Angela
authors.initials: A
authors.lastname: Köninger
authors.affiliation: a Department of Obstetrics and Gynecology , University Hospital of Essen , Essen , Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Kimmig
authors.affiliation: b Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen , Essen , Germany , and.
authors.forename: Börge
authors.initials: B
authors.lastname: Schmidt
authors.affiliation: a Department of Obstetrics and Gynecology , University Hospital of Essen , Essen , Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gellhaus
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D008565:Membrane Proteins / Q000097:blood*; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D016017:Odds Ratio; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D012372:ROC Curve; D012189:Retrospective Studies; D012907:Smoking / Q000097:blood; D016216:Ultrasonography, Prenatal; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins; C098069:PIGF protein, human; D054409:Nicotinamide Phosphoribosyltransferase; D011266:Pregnancy-Associated Plasma Protein-A
keywords: PAPP-A; PlGF; SGA; sFlt-1; visfatin