title: Secreted microRNAs from tumor cells can suppress immune function.
abstract: Our recent study reported an interesting finding that tumor cells can actively manipulate host immune function to facilitate tumor immune escape through the secretion of microRNAs (miRNAs). As an extension of this finding, we showed that blockage of the function of tumor-secreted miRNAs represents an effective therapeutic approach for cancer treatment.
authors.affiliation: Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology (JERC-MBB); State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University ; Nanjing, Jiangsu China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology (JERC-MBB); State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University ; Nanjing, Jiangsu China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liang
authors.affiliation: Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology (JERC-MBB); State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University ; Nanjing, Jiangsu China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zen
authors.affiliation: Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology (JERC-MBB); State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University ; Nanjing, Jiangsu China.
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Zhang
keywords: PTEN; microvesicle; regulatory T cell; secreted microRNA; tumor immune escape