title: Multifunctional protein: cardiac ankyrin repeat protein.
abstract: Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Xie
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Jian-An
authors.initials: JA
authors.lastname: Wang
mesh_terms: D000818:Animals; D017089:Ankyrin Repeat; D017209:Apoptosis; D050197:Atherosclerosis / Q000235:genetics; D006332:Cardiomegaly / Q000235:genetics; D002311:Cardiomyopathy, Dilated / Q000235:genetics; D003593:Cytoplasm / Q000378:metabolism; D004317:Doxorubicin / Q000009:adverse effects; D005786:Gene Expression Regulation; D006321:Heart / Q000196:embryology* / Q000254:growth & development*; D006333:Heart Failure / Q000235:genetics; D006801:Humans; D051379:Mice; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D017202:Myocardial Ischemia / Q000235:genetics; D009206:Myocardium / Q000378:metabolism; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*
chemical_list: C491304:ANKRD1 protein, human; C104844:Ankrd1 protein, mouse; D009124:Muscle Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D004317:Doxorubicin
keywords: Cardiac ankyrin repeat protein (CARP); Cardiac development; Cardiovascular disease