title: Central role for marginal zone B cells in an animal model of Sjogren's syndrome.
abstract: Patients with Sjogren's syndrome (SS) have been shown to have abnormal B cell function and increased numbers of marginal zone B cells (MZB and MZB precursors. The current studies utilized the Interleukin 14 alpha transgenic mouse model (IL14aTG) for SS to investigate the roles of marginal zone B cells (MZB) of the innate immune system in the pathophysiology of the disease. Eliminating MZB from IL14aTG mice by B cell specific deletion of RBP-J resulted in complete elimination of all disease manifestations of SS. Mice had normal salivary gland secretions, negative autoantibodies and normal histology of the salivary and lacrimal glands compared to IL14aTG mice at the same time points. In contrast, eliminating B1 cells by deleting btk did not ameliorate the disease. Therefore, MZB are critical for the development of SS.
authors.affiliation: Department of Medicine, Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine and Biomedical Sciences, United States.
authors.forename: Long
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Medicine, Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine and Biomedical Sciences, United States; Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Oral Diagnostics Sciences, SUNY at Buffalo School of Dental Medicine, United States.
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Suresh
authors.affiliation: Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Xian
authors.affiliation: Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Song
authors.affiliation: Department of Medicine, Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine and Biomedical Sciences, United States.
authors.forename: Lee D
authors.initials: LD
authors.lastname: Chaves
authors.affiliation: Department of Medicine, Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine and Biomedical Sciences, United States.
authors.forename: Meixing
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Medicine, Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine and Biomedical Sciences, United States. Electronic address: jambrus@buffalo.edu.
authors.forename: Julian L
authors.initials: JL
authors.lastname: Ambrus
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D007378:Interleukins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007765:Lacrimal Apparatus / Q000276:immunology / Q000378:metabolism; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D012469:Salivary Glands / Q000276:immunology / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D033921:Vesicular Transport Proteins
chemical_list: D001323:Autoantibodies; D007378:Interleukins; C545985:TXLNA protein, mouse; D033921:Vesicular Transport Proteins