title: Role of Myeloperoxidase in Patients with Chronic Kidney Disease.
abstract: Chronic kidney disease (CKD) is a worldwide public health problem. Patients with CKD have a number of disorders in the organism, and the presence of oxidative stress and systemic inflammation in these patients is the subject of numerous studies. Chronic inflammation joined with oxidative stress contributes to the development of numerous complications: accelerated atherosclerosis process and cardiovascular disease, emergence of Type 2 diabetes mellitus, development of malnutrition, anaemia, hyperparathyroidism, and so forth, affecting the prognosis and quality of life of patients with CKD. In this review we presented the potential role of the myeloperoxidase enzyme in the production of reactive/chlorinating intermediates and their role in oxidative damage to biomolecules in the body of patients with chronic kidney disease and end-stage renal disease. In addition, we discussed the role of modified lipoprotein particles under the influence of prooxidant MPO intermediates in the development of endothelial changes and cardiovascular complications in renal failure.
authors.affiliation: Institute of Biochemistry, Medical Faculty Pristina, Kosovska Mitrovica 38220, Serbia.
authors.forename: Bojana
authors.initials: B
authors.lastname: Kisic
authors.affiliation: Institute of Biochemistry, Medical Faculty Pristina, Kosovska Mitrovica 38220, Serbia.
authors.forename: Dijana
authors.initials: D
authors.lastname: Miric
authors.affiliation: Institute of Biochemistry, Medical Faculty Pristina, Kosovska Mitrovica 38220, Serbia.
authors.forename: Ilija
authors.initials: I
authors.lastname: Dragojevic
authors.affiliation: Institute of Pharmacology, Medical Faculty Pristina, Kosovska Mitrovica 38220, Serbia.
authors.forename: Julijana
authors.initials: J
authors.lastname: Rasic
authors.affiliation: Institute of Pathophysiology, Medical Faculty Pristina, Kosovska Mitrovica 38220, Serbia.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Popovic
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D050171:Dyslipidemias / Q000150:complications; D006801:Humans; D034141:Hypoalbuminemia / Q000150:complications; D007249:Inflammation; D018384:Oxidative Stress; D009195:Peroxidase / Q000235:genetics / Q000378:metabolism*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000201:enzymology* / Q000473:pathology
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D009195:Peroxidase