title: Stimulus-responsiveness and methyl violet release behaviors of poly(NIPAAm-co-AA) hydrogels chemically crosslinked with β-cyclodextrin polymer bearing methacrylates.
abstract: To fabricate thermo- and pH-sensitive hydrogels functionalized with β-cyclodextrin (β-CD) moieties, β-CD polymer bearing methacrylate (CDP-g-GMA) used as a reactive and functional crosslinker was synthesized, and then copolymerized with N-isopropylacrylamide (NIPAAm) and acrylic acid (AA) in aqueous solution via UV-initiated free radical polymerization. The stimulus-responsiveness of the resultant hydrogels has been carried out by measuring the swelling ratio at different temperatures and pH values. The results showed that the thermo- and pH-sensitivities of the produced hydrogels were significantly dependent on the compositions of the hydrogels, and the dual sensitivities exhibited good reversible process. The interior morphology observed by SEM exhibited that the pore size of the hydrogels could be tailored by pH of the local medium. Using a water-soluble cationic dye methyl violet (MV) as a model drug, MV loading and release profiles of the hydrogels as potential drug controlled release carriers were evaluated. The MV release rate from CD-functionalized hydrogels was much slower than that from the hydrogel without β-CDs at both pH 2.0 and pH 7.4. The release of MV from CD-functionalized hydrogels at pH 2.0 was faster than that at pH 7.4, the release kinetics of MV from the CD-functionalized hydrogels displayed a sustained release profile, and the release mechanism followed Fickian diffusion.
authors.affiliation: Key Laboratory of Textile Fibers and Products, Ministry of Education, School of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Textile Fibers and Products, Ministry of Education, School of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.affiliation: Key Laboratory of Textile Fibers and Products, Ministry of Education, School of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, China.
authors.forename: Ruina
authors.initials: R
authors.lastname: Liu
authors.affiliation: Key Laboratory of Textile Fibers and Products, Ministry of Education, School of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, China. Electronic address: zhaosanping@163.com.
authors.forename: Sanping
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D005840:Gentian Violet / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D000179:Acrylates; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D020100:Hydrogels; D008689:Methacrylates; D047392:beta-Cyclodextrins; C067295:N-isopropylacrylamide; D005840:Gentian Violet; C036658:acrylic acid
keywords: Controlled release carriers; Release profile; Swelling ratio; Thermo- and pH-sensitive hydrogels; β-Cyclodextrin polymer