title: Fabrication of chitosan-g-poly(acrylamide)/CuS nanocomposite for controlled drug delivery and antibacterial activity.
abstract: In present study, we reported the synthesis of chitosan-g-poly(acrylamide)/CuS (CPA/CS) nanocomposite for controlled delivery of ofloxacin. The CPA/CS nanocomposites were characterized by Fourier transmission infrared spectroscopy (FTIR), UV-visible spectroscopy (UV), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis. From the FTIR spectra, the various groups present in CPA/CS nanocomposite were monitored. The homogeneity, morphology and crystallinity of the CPA/CS nanocomposite were ascertained from SEM/EDX and XRD data, respectively. The kinetics of ofloxacin drug delivery was investigated at different pH. The drug released studies were investigated at different pH (2.2, 7.4 and 9.4) and time intervals (2, 4, 6, 8, 10, 12, 14, 16h). The drug release behavior depends upon the pH of medium and the nature of matrix. The maximum drug loading efficiency of 85% was recorded for CPA/CS. The maximum drug release of 76% was observed at 2.2. pH after 18h onto CPA/CS. Nanocomposites were also tested for antibacterial activity against Escherichia coli bacteria. About 97% killing of E. coli was observed after 24h.
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., India. Electronic address: dpathania74@gmail.com.
authors.forename: Deepak
authors.initials: D
authors.lastname: Pathania
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., India.
authors.forename: Divya
authors.initials: D
authors.lastname: Gupta
authors.affiliation: Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa.
authors.forename: Shilpi
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Chemical Engineering Department, King Suad University Riyadh, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Asif
authors.affiliation: Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Gupta
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004926:Escherichia coli / Q000254:growth & development*; D053761:Nanocomposites / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D048271:Chitosan; D003300:Copper; D003692:Delayed-Action Preparations; D013440:Sulfides; D000099166:Polyacrylamides
keywords: Acrylamide; Antibacterial; Chitosan; Drug delivery; Nanocomposite; Ofloxacin