title: Drosha and Dicer: Slicers cut from the same cloth.
abstract: DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between components of the Microprocessor and insights into its 'ruler'-based cleavage activity and function.
authors.affiliation: Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong 518055, China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong 518055, China.|Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Dinshaw J
authors.initials: DJ
authors.lastname: Patel
mesh_terms: D006801:Humans; D035683:MicroRNAs; D016601:RNA-Binding Proteins; D043244:Ribonuclease III
chemical_list: D035683:MicroRNAs; D016601:RNA-Binding Proteins; C517918:DROSHA protein, human; D043244:Ribonuclease III