title: KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions.
abstract: Ovarian low-grade serous carcinoma is thought to begin as a serous cystadenoma or adenofibroma that progresses in a slow stepwise fashion. Among the low-grade serous carcinomas, there is a high frequency of activating mutations in the KRAS or BRAF genes; however, it remains unclear as to how these mutations contribute to tumor progression. This is the first report to track the histopathological progression of serous adenofibroma to low-grade serous carcinoma. Each stage was individually analyzed by pathological and molecular genetic methods to determine what differences occur between the distinct stages of progression.
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. kohei320@med.shimane-u.ac.jp.
authors.forename: Kohei
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. kn88@med.shimane-u.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakayama
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. tomoka19850314@gmail.com.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Ishibashi
authors.affiliation: Department of Organ Pathology, Shimane University School of Medicine, Izumo 6938501, Japan. kanatomo@med.shimane-u.ac.jp.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ishikawa
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. pcbashi4@yahoo.co.jp.
authors.forename: Masako
authors.initials: M
authors.lastname: Ishikawa
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. hkata@med.shimane-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Katagiri
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. tokominmin@gmail.com.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Minamoto
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. prettynanaone@gmail.com.
authors.forename: Emi
authors.initials: E
authors.lastname: Sato
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. kaorisanuki@gmail.com.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sanuki
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. memedasudasu1103@gmail.com.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Yamashita
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. iida@med.shimane-u.ac.jp.
authors.forename: Kouji
authors.initials: K
authors.lastname: Iida
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. raeedahmed@yahoo.com.
authors.forename: Razia
authors.initials: R
authors.lastname: Sultana
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. satoruky@med.shimane-u.ac.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kyo
mesh_terms: D018284:Cystadenocarcinoma, Serous / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D016133:Polymerase Chain Reaction; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D018631:ras Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D048493:Proto-Oncogene Proteins B-raf; D018631:ras Proteins
keywords: BRAF; KRAS; low-grade serous carcinoma; mutation