title: Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions.
abstract: The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development. Beyond the classical NF-κB activation pathway, a second NF-κB pathway has more recently been uncovered, the so-called alternative NF-κB activation pathway. It has been shown that this pathway mainly controls the activity of RelB, a member of the NF-κB family. Post-translational modifications, such as phosphorylation, acetylation, methylation, ubiquitination and SUMOylation, have recently emerged as a strategy for the fine-tuned regulation of NF-κB. Our review discusses recent progress in the understanding of RelB regulation by post-translational modifications and the associated functions in normal and pathological conditions.
authors.affiliation: NF-κB, Differentiation and Cancer, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. veronique.baud@inserm.fr.
authors.forename: Véronique
authors.initials: V
authors.lastname: Baud
authors.affiliation: NF-κB, Differentiation and Cancer, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
authors.forename: Davi
authors.initials: D
authors.lastname: Collares
keywords: NF-kappaB; NF-κB alternative pathway; RelB; SUMOylation; cell motility; phosphorylation; post-translational modifications; ubiquitination