title: Presenile diffuse familial sebaceous hyperplasia successfully treated with low-dose isotretinoin: A report of two cases and review of the published work.
abstract: Presenile diffuse familial sebaceous hyperplasia (PDFSH) presents as extensive yellowish papules with central umbilication on the face without involvement of periorificial regions and occurs in adolescents or young adults with a positive family history. Thirteen cases of PDFSH have been reported in the English-language published work, 10 of which responded to oral isotretinoin from 0.5 to 1 mg/kg per day but recurrences were often observed. Herein, we report two cases of PDFSH, which were successfully managed without recurrence with prolonged low-dose isotretinoin (0.2 mg/kg per day, a cumulative dose of 41 and 64 mg/kg, respectively). Treatment protocols among different published works were reviewed to verify the efficacy of isotretinoin.
authors.affiliation: Department of Dermatology, Hsinchu Cathay General Hospital, Hsinchu City, Taiwan.|Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan.
authors.forename: You-Chen Serena
authors.initials: YS
authors.lastname: Liu
authors.affiliation: Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan.|Department of Dermatology, National Taiwan University Hospital, Taipei City, Taiwan.|Department of Dermatology, National Taiwan University Hospital Hsinchu Branch, Hsinchu City, Taiwan.
authors.forename: Yu-Pin
authors.initials: YP
authors.lastname: Cheng
authors.affiliation: Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan.
authors.forename: Chuan-I
authors.initials: CI
authors.lastname: Liu
authors.affiliation: Department of Dermatology, Chang-Gung Memorial Hospital, Taipei City, Taiwan.
authors.forename: Chin-Yi
authors.initials: CY
authors.lastname: Yang
authors.affiliation: Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan. yangchiayi@gmail.com.|Department of Dermatology, National Taiwan University Hospital, Taipei City, Taiwan. yangchiayi@gmail.com.
authors.forename: Chia-Yi
authors.initials: CY
authors.lastname: Yang
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D002610:Cheek / Q000473:pathology; D002985:Clinical Protocols; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D000068298:Fluticasone / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006965:Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D015474:Isotretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D060046:Maintenance Chemotherapy; D008297:Male; D012008:Recurrence; D012627:Sebaceous Glands / Q000473:pathology*; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents; D014212:Tretinoin; D000068298:Fluticasone; D015474:Isotretinoin
keywords: androgen; familial presenile sebaceous gland hyperplasia; isotretinoin; sebaceous gland diseases; sebaceous glands