title: Reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly Chinese men.
abstract: OBJECTIVE
  The present study was intended to establish the reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly (aged 80 years or more) Chinese men.
  
  
  METHODS
  A total of 1316 very elderly Chinese men were recruited into the study, and subjected to a survey of clinical characteristics, measurements of bone mineral density and assays of bone turnover markers. The relationships between underlying diseases and bone turnover markers were investigated, and the reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly Chinese men were established through defining the central 95% range of all observations.
  
  
  RESULTS
  We found that type 2 diabetes mellitus, chronic obstructive pulmonary disease and abnormal bone mass were associated with serum bone turnover markers (P < 0.01), and thereby identified 208 men without type 2 diabetes mellitus, chronic obstructive pulmonary disease and/or abnormal bone mass as healthy participants from 1316 very elderly Chinese men. The reference intervals for very elderly Chinese men were 0.13-0.63 ng/mL for β-C-terminal telopeptide of type I collagen, 18-94 ng/mL for procollagen type I N-terminal propeptide and 9-28 ng/mL for osteocalcin, respectively. The three turnover markers were moderately correlated to each other (P < 0.001), and all negatively associated with the bone mineral density of three sites (P < 0.05).
  
  
  CONCLUSIONS
  We have established the reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly Chinese men. Geriatr Gerontol Int 2017; 17: 773-778.
authors.affiliation: Department of Pharmaceutical Science, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Zhangxuan
authors.initials: Z
authors.lastname: Shou
authors.affiliation: Department of Pharmaceutical Science, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Jin
authors.affiliation: Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Pingda
authors.initials: P
authors.lastname: Bian
authors.affiliation: Department of Epidemiology & Health Statistics, Zhejiang University, Hangzhou, China.
authors.forename: Xiuyang
authors.initials: X
authors.lastname: Li
authors.affiliation: Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Chen
mesh_terms: D015502:Absorptiometry, Photon; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D024042:Collagen Type I / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D015675:Osteocalcin / Q000097:blood*; D010024:Osteoporosis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D010384:Pelvic Bones / Q000000981:diagnostic imaging*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; D015675:Osteocalcin
keywords: Bone turnover marker; osteocalcin; procollagen type I N-terminal propeptide; very elderly male; β-C-terminal telopeptide of type I collagen