title: The Involvement of PDGF-B/PDGFRβ Axis in the Resistance to Antiangiogenic and Antivascular Therapy in Renal Cancer.
abstract: OBJECTIVE
  Studies developed in the field of platelet-derived growth factors/platelet-derived growth factor receptors (PDGFs/PDGFRs) inhibition have focused on the therapeutic effects on tumor cells, neglecting their potential effects on tumor blood vessels. We herein propose a differential and critic assessment of platelet-derived growth factor B (PDGF-B) and platelet-derived growth factor receptor β (PDGFRβ) in renal cell carcinoma, correlated with the four main vascular patterns previously reported by our team.
  
  
  METHODS
  PDGF-B and PDGFRβ were evaluated on 50 archival paraffin embedded specimens related to vascular endothelial growth factor (VEGF), its inhibitory isoform VEGF165b and vascular patterns.
  
  
  CONCLUSIONS
  Our results support the involvement of VEGF165b in the phosphorylation of PDGFRβ with an inhibitory effect on endothelial proliferation and migration. The simultaneous action of PDGF-B/PDGFRβ and VEGF165b on the same type of receptor may explain the resistance to antiangiogenic therapy, which depends on the degree of modulation of PDGFRβ phosphorylation.
authors.affiliation: Department of Ortophedic Surgery, Traumatology and Urology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
authors.forename: Alin Adrian
authors.initials: AA
authors.lastname: Cumpănas
authors.affiliation: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Timisoara, Romania ancacimpean1972@yahoo.com.
authors.forename: Anca Maria
authors.initials: AM
authors.lastname: Cimpean
authors.affiliation: Department of Ortophedic Surgery, Traumatology and Urology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Ferician
authors.affiliation: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Timisoara, Romania.
authors.forename: Raluca Amalia
authors.initials: RA
authors.lastname: Ceausu
authors.affiliation: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Timisoara, Romania.
authors.forename: Simona
authors.initials: S
authors.lastname: Sarb
authors.affiliation: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Timisoara, Romania.
authors.forename: Vlad
authors.initials: V
authors.lastname: Barbos
authors.affiliation: Department of Pathology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
authors.forename: Alice
authors.initials: A
authors.lastname: Dema
authors.affiliation: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Timisoara, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Raica
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000077214:Becaplermin; D002292:Carcinoma, Renal Cell / Q000098:blood supply / Q000737:chemistry / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D006801:Humans; D007680:Kidney Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000378:metabolism; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011499:Protein Processing, Post-Translational; D020574:Proto-Oncogene Proteins c-sis / Q000032:analysis / Q000502:physiology*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000032:analysis / Q000037:antagonists & inhibitors / Q000502:physiology*; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000502:physiology*
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D020574:Proto-Oncogene Proteins c-sis; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000077214:Becaplermin; D020797:Receptor, Platelet-Derived Growth Factor beta
keywords: PDGF-B; PDGFRβ; kidney cancer; tumor angiogenesis