title: 64 slice-coronary computed tomography sensitivity and specificity in the evaluation of coronary artery bypass graft stenosis: A meta-analysis.
abstract: A non-invasive approach to define grafts patency and stenosis in the follow-up of coronary artery bypass graft (CABG) patients may be an interesting alternative to coronary angiography. 64-slice-coronary computed tomography is nowadays a diffused non-invasive method that permits an accurate evaluation of coronary stenosis, due to a high temporal and spatial resolution. However, its sensitivity and specificity in CABG evaluation has to be clearly defined, since published studies used different protocols and scanners. We collected all studies investigating patients with stable symptoms and previous CABG and reporting the comparison between diagnostic performances of invasive coronary angiography and 64-slice-coronary computed tomography. As a result, sensitivity and specificity of 64-slice-coronary computed tomography for CABG occlusion were 0.99 (95% CI 0.97-1.00) and 0.99 (95% CI: 0.99-1.00) with an area under the curve (AUC) of 0.99. 64-slice-coronary computed tomography sensitivity and specificity for the presence of any CABG stenosis >50% were 0.98 (95% CI: 0.97-0.99) and 0.98 (95% CI: 0.96-0.98), while AUC was 0.99. At meta-regression, neither the age nor the time from graft implantation had effect on sensitivity and specificity of 64-slice-coronary computed tomography detection of significant CABG stenosis or occlusion. In conclusion 64-slice-coronary computed tomography confirmed its high sensitivity and specificity in CABG stenosis or occlusion evaluation.
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy. Electronic address: u.barbero@gmail.com.
authors.forename: Umberto
authors.initials: U
authors.lastname: Barbero
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Iannaccone
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: d'Ascenzo
authors.affiliation: Cardiac Surgery Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Barbero
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Abdirashid
authors.initials: A
authors.lastname: Mohamed
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Annone
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Benedetto
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Celentani
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Gagliardi
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Moretti
authors.affiliation: Cardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Gaita
mesh_terms: D019540:Area Under Curve; D017023:Coronary Angiography / Q000379:methods*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Coronary artery by-pass graft; Coronary artery disease; Coronary artery stenosis; Coronary computed tomography