title: Glycans and the platelet life cycle.
abstract: Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A recent study in mice identified a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes. This new finding generated renewed interest in platelet clearance mechanisms. Here, different established and emerging mechanisms of platelet senescence and clearance will be reviewed with specific emphasis on the role of posttranslational modifications.
authors.affiliation: a Aflac Cancer and Blood Disorders Center, Department of Pediatrics , Emory University School of Medicine , Atlanta , GA , USA.
authors.forename: Renhao
authors.initials: R
authors.lastname: Li
authors.affiliation: b Division of Hematology, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA.
authors.forename: Karin M
authors.initials: KM
authors.lastname: Hoffmeister
authors.affiliation: b Division of Hematology, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA.
authors.forename: Hervé
authors.initials: H
authors.lastname: Falet
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D001791:Blood Platelet Disorders / Q000209:etiology / Q000378:metabolism; D001792:Blood Platelets / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D016922:Cellular Senescence / Q000235:genetics / Q000276:immunology; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000737:chemistry / Q000378:metabolism; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D011134:Polysaccharides / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D002352:Carrier Proteins; D037102:Lectins; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011134:Polysaccharides; C094990:adhesion receptor; D006026:Glycoside Hydrolases
keywords: Ashwell-Morell receptor; GPIbα; platelet clearance; sialic acid