title: Comparison of Etanercept Monotherapy and Combination Therapy with Methotrexate in Psoriatic Arthritis: Results from 2 Clinical Trials.
abstract: To evaluate the clinical/functional outcomes associated with etanercept (ETN) monotherapy versus combination therapy in psoriatic arthritis (PsA).
  
  
  
  Data from patients with PsA who received ETN alone (n = 322) or combined with methotrexate (MTX; n = 152) for 24 weeks in 2 placebo-controlled clinical trials were summarized across studies.
  
  
  
  Similar proportions of patients in the monotherapy and combination therapy groups achieved the PsA Response Criteria (80% and 83%) and the American College of Rheumatology improvements of 20% (ACR20; both 70%); numerically higher proportions receiving monotherapy achieved ACR50 (55% vs 48%) and ACR70 (35% vs 27%). Little between-group difference was observed in the 28-joint Disease Activity Score with C-reactive protein, the Psoriasis Area and Severity Index, and the Health Assessment Questionnaire-Disability Index improvement.
  
  
  
  ETN with and without MTX provided similar benefits in active PsA.
authors.affiliation: From the Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University, Montpellier, France; CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath, Bath; Statistical Consultancy, Quanticate, Hitchin; Pfizer United Kingdom, Tadworth, UK; Pfizer Europe, Rome, Italy.B. Combe, MD, Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University; F. Behrens, MD, CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology; N. McHugh, MD, Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath; F. Brock, MSc, Statistical Consultancy, Quanticate; U. Kerkmann, MD, former employee of Pfizer Europe; B. Kola, MD, Pfizer United Kingdom; G. Gallo, MD, Pfizer Europe. b-combe@chu-montpellier.fr.
authors.forename: Bernard
authors.initials: B
authors.lastname: Combe
authors.affiliation: From the Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University, Montpellier, France; CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath, Bath; Statistical Consultancy, Quanticate, Hitchin; Pfizer United Kingdom, Tadworth, UK; Pfizer Europe, Rome, Italy.B. Combe, MD, Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University; F. Behrens, MD, CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology; N. McHugh, MD, Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath; F. Brock, MSc, Statistical Consultancy, Quanticate; U. Kerkmann, MD, former employee of Pfizer Europe; B. Kola, MD, Pfizer United Kingdom; G. Gallo, MD, Pfizer Europe.
authors.forename: Frank
authors.initials: F
authors.lastname: Behrens
authors.affiliation: From the Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University, Montpellier, France; CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath, Bath; Statistical Consultancy, Quanticate, Hitchin; Pfizer United Kingdom, Tadworth, UK; Pfizer Europe, Rome, Italy.B. Combe, MD, Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University; F. Behrens, MD, CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology; N. McHugh, MD, Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath; F. Brock, MSc, Statistical Consultancy, Quanticate; U. Kerkmann, MD, former employee of Pfizer Europe; B. Kola, MD, Pfizer United Kingdom; G. Gallo, MD, Pfizer Europe.
authors.forename: Neil
authors.initials: N
authors.lastname: McHugh
authors.affiliation: From the Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University, Montpellier, France; CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath, Bath; Statistical Consultancy, Quanticate, Hitchin; Pfizer United Kingdom, Tadworth, UK; Pfizer Europe, Rome, Italy.B. Combe, MD, Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University; F. Behrens, MD, CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology; N. McHugh, MD, Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath; F. Brock, MSc, Statistical Consultancy, Quanticate; U. Kerkmann, MD, former employee of Pfizer Europe; B. Kola, MD, Pfizer United Kingdom; G. Gallo, MD, Pfizer Europe.
authors.forename: Fiona
authors.initials: F
authors.lastname: Brock
authors.affiliation: From the Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University, Montpellier, France; CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath, Bath; Statistical Consultancy, Quanticate, Hitchin; Pfizer United Kingdom, Tadworth, UK; Pfizer Europe, Rome, Italy.B. Combe, MD, Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University; F. Behrens, MD, CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology; N. McHugh, MD, Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath; F. Brock, MSc, Statistical Consultancy, Quanticate; U. Kerkmann, MD, former employee of Pfizer Europe; B. Kola, MD, Pfizer United Kingdom; G. Gallo, MD, Pfizer Europe.
authors.forename: Urs
authors.initials: U
authors.lastname: Kerkmann
authors.affiliation: From the Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University, Montpellier, France; CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath, Bath; Statistical Consultancy, Quanticate, Hitchin; Pfizer United Kingdom, Tadworth, UK; Pfizer Europe, Rome, Italy.B. Combe, MD, Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University; F. Behrens, MD, CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology; N. McHugh, MD, Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath; F. Brock, MSc, Statistical Consultancy, Quanticate; U. Kerkmann, MD, former employee of Pfizer Europe; B. Kola, MD, Pfizer United Kingdom; G. Gallo, MD, Pfizer Europe.
authors.forename: Blerina
authors.initials: B
authors.lastname: Kola
authors.affiliation: From the Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University, Montpellier, France; CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath, Bath; Statistical Consultancy, Quanticate, Hitchin; Pfizer United Kingdom, Tadworth, UK; Pfizer Europe, Rome, Italy.B. Combe, MD, Rheumatology Department, Lapeyronie Hospital, Montpellier 1 University; F. Behrens, MD, CIRI/Rheumatology, Goethe-University and Fraunhofer IME, Translational Medicine and Pharmacology; N. McHugh, MD, Royal National Hospital for Rheumatic Diseases and Department of Pharmacy and Pharmacology, University of Bath; F. Brock, MSc, Statistical Consultancy, Quanticate; U. Kerkmann, MD, former employee of Pfizer Europe; B. Kola, MD, Pfizer United Kingdom; G. Gallo, MD, Pfizer Europe.
authors.forename: Gaia
authors.initials: G
authors.lastname: Gallo
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy*; D004185:Disability Evaluation; D004359:Drug Therapy, Combination; D000068800:Etanercept / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D000068800:Etanercept; D008727:Methotrexate
keywords: BIOLOGIC; DISEASE-MODIFYING ANTIRHEUMATIC DRUGS; ETANERCEPT; METHOTREXATE; PSORIATIC ARTHRITIS