title: 2,4-Diarylpyrano[3,2-c]chromen-5(4H)-ones as Antiproliferative Agents.
abstract: In the present study, a series of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-ones were synthesised and evaluated as antiproliferative agents. The compounds were evaluated against a panel of human cancer cell lines. CH-1 exhibited significant cytoxicity against HCT 116 cell lines with an IC50 value of 1.4 and 4.3 µM against "MiaPaCa-2" cell lines. The compound CH-1 was found to induce apoptosis as evidenced by phase contrast microscopy, Hoechst 33258 staining and mitochondrial membrane potential (MMP) loss. The cell phase distribution studies indicated that the apoptotic population increased from 10.22% in the control sample to 57.19% in a sample treated with 20 µM compound CH-1.
authors.affiliation: Department of Pharmaceutical Sciences, Guru Nanak Dev University.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kumar
authors.forename: Fayaz
authors.initials: F
authors.lastname: Malik
authors.forename: Preet Mohinder Singh
authors.initials: PM
authors.lastname: Bedi
authors.forename: Subheet
authors.initials: S
authors.lastname: Jain
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002867:Chromones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051336:Mitochondrial Membranes / Q000187:drug effects; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002867:Chromones