title: Endocrine dysfunction and recurrent spontaneous abortion: An overview.
abstract: Miscarriage is the spontaneous loss of a fetus before it is viable, occurring at a rate of 15-20%. Recurrent spontaneous abortion (RSA) or habitual miscarriage is defined as repeated occurrence of 3 or more miscarriages before 20(th) week of gestation accounting for the most common complication of early pregnancy in humans. Various etiological factors responsible for recurrent miscarriage are anatomical, genetical, endocrinological, immunological, and infectious. The endocrinological abnormalities may be polycystic ovarian syndrome, hyperprolactinemia, luteal phase defect, thyroid dysfunction, diabetes, or hyperandrogenism contributing to recurrent pregnancy loss. In the present article, the role of endocrinological disorders in patients with RSA has been reviewed. The article search was done using electronic databases, Google scholarly articles, and PubMed based on different key words. We have further combined the searches and made grouping as per various endocrine abnormalities, which might be responsible to cause spontaneous loss of fetus.
authors.affiliation: Centre for Interdisciplinary Biomedical Research, Adesh University, Bathinda, Punjab, India.
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Kaur
authors.affiliation: Department of Biochemistry, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Gupta
keywords: Hyperandrogenism; hyperprolactinemia; luteal phase defect; polycystic ovarian disease; recurrent spontaneous abortion; thyroid dysfunction