title: Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells.
abstract: Recent high-profile studies report GDF11 to be a key circulating 'anti-aging' factor. However, a screen of extracellular proteins attempting to identify factors with 'anti-aging' phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take.
authors.affiliation: GlaxoSmithKline, Muscle Metabolism Discovery Performance Unit, 709 Swedeland Road, King of Prussia, PA, 19406, USA.
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Hinken
authors.affiliation: Five Prime Therapeutics, Two Corporate Drive, South San Francisco, CA, 94080, USA.
authors.forename: Janine M
authors.initials: JM
authors.lastname: Powers
authors.affiliation: GlaxoSmithKline, Muscle Metabolism Discovery Performance Unit, 709 Swedeland Road, King of Prussia, PA, 19406, USA.
authors.forename: Guizhen
authors.initials: G
authors.lastname: Luo
authors.affiliation: GlaxoSmithKline, Muscle Metabolism Discovery Performance Unit, 709 Swedeland Road, King of Prussia, PA, 19406, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Holt
authors.affiliation: GlaxoSmithKline, Muscle Metabolism Discovery Performance Unit, 709 Swedeland Road, King of Prussia, PA, 19406, USA.
authors.forename: Andrew N
authors.identifier: 0000-0001-7752-0934
authors.initials: AN
authors.lastname: Billin
authors.affiliation: GlaxoSmithKline, Muscle Metabolism Discovery Performance Unit, 709 Swedeland Road, King of Prussia, PA, 19406, USA.
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Russell
mesh_terms: D000818:Animals; D002452:Cell Count; D016922:Cellular Senescence / Q000187:drug effects*; D055412:Growth Differentiation Factors / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
chemical_list: D055412:Growth Differentiation Factors; D011994:Recombinant Proteins
keywords: GDF11; Satellite cell; aging