title: Effect of carotid endarterectomy on brain damage markers.
abstract: OBJECTIVE
  Carotid endarterectomy (CEA) is a recommended treatment in the prevention of ischemic stroke. However, this procedure may cause neurological complications caused by cerebrovascular damage. While YKL-40 is a proinflammatory protein, neurofilament light polypeptide (NEFL) and brain lipid-binding protein (FABP7) are structural components of the brain. The aim of the study was to investigate YKL-40, NEFL, and FABP7 in the serum of patients undergoing CEA.
  
  
  METHODS
  The study included 25 participants who underwent CEA due to internal carotid artery stenosis. Blood samples were taken from each patient at three different intervals: prior to the surgery, 12 h after the surgery, and 48 h after the surgery. Serum levels of these brain damage markers were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The study showed that the serum YKL-40 level was significantly increased 48 h after CEA when compared to the level prior to surgery and also when compared to levels 12 h after surgery. There were no statistically significant differences in serum NEFL and FABP7 levels between all three recorded measurements.
  
  
  CONCLUSIONS
  Data from our study showed that CEA affects serum YKL-40 but not NEFL and FABP7 levels. This implicates that YKL-40 may be a valuable serum marker of brain damage after CEA. However, the observed change in serum YKL-40 level in patients after CEA does not necessarily warrant a change in recommendations concerning the use of this treatment in patients with high-grade internal carotid artery stenosis.
authors.affiliation: Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Iłżecki
authors.affiliation: Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.|Independent Neurological Rehabilitation Unit, Medical University of Lublin, Lublin, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Iłżecka
authors.affiliation: Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Przywara
authors.affiliation: Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Terlecki
authors.affiliation: Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Grabarska
authors.affiliation: Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Stepulak
authors.affiliation: Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Zubilewicz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016893:Carotid Stenosis / Q000601:surgery*; D000071451:Chitinase-3-Like Protein 1 / Q000097:blood*; D016894:Endarterectomy, Carotid / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D000071438:Fatty Acid-Binding Protein 7 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood*; D020521:Stroke / Q000517:prevention & control*; D016896:Treatment Outcome; D025521:Tumor Suppressor Proteins / Q000097:blood*
chemical_list: D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D016900:Neurofilament Proteins; D025521:Tumor Suppressor Proteins; C044882:neurofilament protein L
keywords: YKL-40; brain lipid-binding protein; carotid endarterectomy; neurofilament light; serum neuromarkers