title: Aging of platelets stored for transfusion.
abstract: A goal of platelet storage is to maintain the quality of platelets from the point of donation to the point of transfusion - to suspend the aging process. This effort is judged by clinical and laboratory measures with varying degrees of success. Recent work gives encouragement that platelets can be maintained ex vivo beyond the current 5 -7 day shelf life whilst maintaining their quality, as measured by posttransfusion recovery and survival. However, additional measures are needed to validate the development of technologies that may further reduce the aging of stored platelets, or enhance their hemostatic properties.
authors.affiliation: a Components Development Laboratory, NHS Blood and Transplant, Cambridge, UK, and Department of Haematology , University of Cambridge , Cambridge , UK.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Smethurst
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001793:Blood Preservation / Q000009:adverse effects; D058731:Blood Safety; D016922:Cellular Senescence; D006801:Humans; D017713:Platelet Transfusion / Q000009:adverse effects / Q000379:methods / Q000592:standards; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome
keywords: Storage; aging; transfusion