title: Drug-induced Hypersensitivity Syndrome Accompanied by Pulmonary Lesions Exhibiting Centrilobular Nodular Shadows.
abstract: A 51-year-old woman diagnosed with Crohn's disease developed drug-induced hypersensitivity syndrome (DIHS) 12 and six weeks after starting the oral intake of mesalazine and trimethoprim/sulfamethoxazole, respectively. Chest CT showed centrilobular nodular shadows and a transbronchial lung biopsy (TBLB) revealed infiltration of inflammatory cells predominantly in the small pulmonary artery walls and bronchiolar walls. Regarding pulmonary lesions of DIHS, infiltrative shadows have sometimes been reported, whereas nodular shadows have rarely been documented. This is a valuable case report for considering the mechanism underlying the development of pulmonary lesions in case of DIHS.
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sawata
authors.forename: Masashi
authors.initials: M
authors.lastname: Bando
authors.forename: Haruna
authors.initials: H
authors.lastname: Kogawara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakayama
authors.forename: Naoko
authors.initials: N
authors.lastname: Mato
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yamasawa
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takemura
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Sugiyama
mesh_terms: D003424:Crohn Disease / Q000188:drug therapy; D004338:Drug Combinations; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced*; D019804:Mesalamine / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011651:Pulmonary Artery / Q000473:pathology; D013419:Sulfamethizole / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014295:Trimethoprim / Q000009:adverse effects* / Q000627:therapeutic use; D000096926:Benzenesulfonamides
chemical_list: D004338:Drug Combinations; D019804:Mesalamine; D013419:Sulfamethizole; D014295:Trimethoprim; C029078:trimethoprim sulfamethizole; D000096926:Benzenesulfonamides