title: Comparison of size modulation and conventional standard automated perimetry with the 24-2 test protocol in glaucoma patients.
abstract: This prospective randomized study compared test results of size modulation standard automated perimetry (SM-SAP) performed with the Octopus 600 and conventional SAP (C-SAP) performed with the Humphrey Field Analyzer (HFA) in glaucoma patients. Eighty-eight eyes of 88 glaucoma patients underwent SM-SAP and C-SAP tests with the Octopus 600 24-2 Dynamic and HFA 24-2 SITA-Standard, respectively. Fovea threshold, mean defect, and square loss variance of SM-SAP were significantly correlated with the corresponding C-SAP indices (P < 0.001). The false-positive rate was slightly lower, and false-negative rate slightly higher, with SM-SAP than C-SAP (P = 0.002). Point-wise threshold values obtained with SM-SAP were moderately to strongly correlated with those obtained with C-SAP (P < 0.001). The correlation coefficients of the central zone were significantly lower than those of the middle to peripheral zone (P = 0.031). The size and depth of the visual field (VF) defect were smaller (P = 0.039) and greater (P = 0.043), respectively, on SM-SAP than on C-SAP. Although small differences were observed in VF sensitivity in the central zone, the defect size and depth and the reliability indices between SM-SAP and C-SAP, global indices of the two testing modalities were well correlated.
authors.affiliation: Orthoptics and Visual Science, Department of Rehabilitation, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hirasawa
authors.affiliation: Orthoptics and Visual Science, Department of Rehabilitation, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shoji
authors.affiliation: Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kasahara
authors.affiliation: Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsumura
authors.affiliation: Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Kimiya
authors.initials: K
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests / Q000295:instrumentation / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult