title: Granuloma Faciale and Erythema Elevatum Diutinum in Relation to Immunoglobulin G4-Related Disease: An Appraisal of 32 Cases.
abstract: OBJECTIVE
  To elucidate whether granuloma faciale (GF) and erythema elevatum diutinum (EED), two inflammatory skin dermatoses, meet the consensus histopathologic diagnostic criteria for immunoglobulin G4-related disease (IgG4-RD).
  
  
  METHODS
  With institutional review board approval, we assessed the clinical, microscopic, and immunophenotypic features of skin specimens of patients with GF and EED. We compared these findings with previously published consensus diagnostic criteria for IgG4-RD.
  
  
  RESULTS
  Thirty-two patients (GF, n = 25; EED, n = 7) met study inclusion criteria. Histopathologic findings of small-vessel vasculitis, dermal fibrosis, and plasma cell infiltrates were uniformly present, and eosinophilic inflammation was frequent. No specimen met diagnostic criteria for IgG4-RD.
  
  
  CONCLUSIONS
  Our results indicate that despite some histopathologic similarities between GF/EED and IgG4-RD, the cases did not meet the consensus immunohistochemical diagnostic criteria for IgG4-RD.
authors.affiliation: From the Department of Medicine, Presence Saint Francis Hospital, University of Illinois, Evanston.
authors.forename: Sima
authors.initials: S
authors.lastname: Kavand
authors.affiliation: Departments of Dermatology, Pathology and Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, MN.
authors.forename: Julia S
authors.initials: JS
authors.lastname: Lehman
authors.affiliation: Departments of Dermatology, Pathology and Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, MN. gibson.lawrence@mayo.edu.
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Gibson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006099:Granuloma / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
chemical_list: D007074:Immunoglobulin G
keywords: Cutaneous vasculitis; Erythema elevatum diutinum; Granuloma faciale; IgG4; IgG4-related disease; IgG4-related skin disease