title: Safety of available treatment options for renal cell carcinoma.
abstract: BACKGROUND
  For many years, cytokines (high-dose interleukin (IL)-2 and interferon (IFN)) have been the unique available treatment options for metastatic renal cell carcinoma (mRCC) and they provided durable but modest responses at the cost of significant toxicities. To date, targeted therapies have replaced cytokine therapy due to higher response rates and more favorable toxicity profiles. The major classes of targeted therapy for mRCC include tyrosine kinase inhibitors, monoclonal antibody against vascular endothelial grow factors and inhibitors of the mammalian target of rapamycin. Thanks to these new strategies, the prognosis for the mRCC is shifting toward a chronic disease and the new challenges are the adequate treatment of adverse events (AEs) and the care for quality of life, which is crucial. Emerging immunotherapies targeting the programmed death-1 (PD-1) receptor and the programmed death ligand-1 (PD-L1) ligand have shown promising results in both efficacy and safety profiles.
  
  
  METHODS
  Safety data published on available treatment options for renal cell carcinoma RCC are reviewed.
  
  
  CONCLUSIONS
  Various toxicities are associated with targeted agents; these toxicities are generally well tolerated but careful monitoring and appropriate management are needed to optimize the use of these strategies.
authors.affiliation: a Gustave Roussy Cancer Campus.
authors.forename: Lisa
authors.initials: L
authors.lastname: Derosa
authors.affiliation: a Gustave Roussy Cancer Campus.
authors.forename: Laurence
authors.initials: L
authors.lastname: Albiges
authors.affiliation: a Gustave Roussy Cancer Campus.
authors.forename: Christophe
authors.initials: C
authors.lastname: Massard
authors.affiliation: a Gustave Roussy Cancer Campus.
authors.forename: Yohann
authors.initials: Y
authors.lastname: Loriot
authors.affiliation: a Gustave Roussy Cancer Campus.
authors.forename: Karim
authors.initials: K
authors.lastname: Fizazi
authors.affiliation: a Gustave Roussy Cancer Campus.
authors.forename: Bernard
authors.initials: B
authors.lastname: Escudier
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology; D016207:Cytokines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D011379:Prognosis; D011788:Quality of Life
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines
keywords: Renal cell carcinoma; checkpoint inhibitors; immunotherapies; mammalian target of rapamycin; targeted therapy; vascular endothelial growth factor