title: Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy.
abstract: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation-based therapy.
  
  
  
  This retrospective study included 100 patients with piriform sinus carcinomas who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography (PET). The association between clinical factors, including the MTV, and survival was analyzed.
  
  
  
  Kaplan-Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV (p < .001), nodal metastasis (p = .011), and applied chemotherapy regimen (p = .004) were found to be independent prognostic factors for DFS.
  
  
  
  The locoregional MTV is a prognostic factor for DFS in patients with piriform sinus carcinoma treated by radiation-based therapy. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan. k_yabuki@yokohama-cu.ac.jp.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yabuki
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sano
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Shiono
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Arai
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Chiba
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Tanabe
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Goshi
authors.initials: G
authors.lastname: Nishimura
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Taguchi
authors.affiliation: Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneta
authors.affiliation: Department of Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hata
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Oridate
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D059248:Chemoradiotherapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D056144:Pyriform Sinus / Q000473:pathology; D012372:ROC Curve; D012189:Retrospective Studies; D047368:Tumor Burden
keywords: concurrent chemoradiotherapy; metabolic tumor volume; piriform sinus carcinoma; radiotherapy; survival