title: What goes around comes around: novel pharmacological targets in the gut-brain axis.
abstract: The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: González-Arancibia
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Jorge
authors.initials: J
authors.lastname: Escobar-Luna
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: Barrera-Bugueño
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Camilo
authors.initials: C
authors.lastname: Díaz-Zepeda
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: María P
authors.initials: MP
authors.lastname: González-Toro
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Loreto
authors.initials: L
authors.lastname: Olavarría-Ramírez
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Francesca
authors.initials: F
authors.lastname: Zanelli-Massai
authors.affiliation: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Martin
authors.initials: M
authors.lastname: Gotteland
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Bravo
authors.affiliation: Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Avenida Universidad 330, Curauma, Valparaíso, Chile.
authors.forename: Marcela
authors.initials: M
authors.lastname: Julio-Pieper
keywords: enteric nervous system; gut–brain axis; interleukin 22; intestinal microbiota; serotonin; vagus nerve