title: Severe meningeal fibrinoid vasculitis associated with Theileria taurotragi infection in two short-horned Zebu cattle.
abstract: The Authors describe a severe vasculitis with fibrinoid necrosis of the meningeal arteries observed in two brains of indigenous short-horn zebu (Bos indicus) cattle, with bovine cerebral theileriosis (BCT) caused by a tick-transmitted hemoprotozoan, Theileria taurotragi, from Northern Tanzania. In the Author's opinion, the role of T. taurotragi infection in the angiocentric and angiodestructive detected features remains to be evaluated. A possible immunopathologic cancerous mechanism, secondary to the lymphoid deregulation, could be involved. This report suggests further studies to better characterize the lymphoid cell involvement in the pathogenesis of the meningeal vascular lesions by T. taurotragi.
authors.affiliation: Department of Veterinary Sciences, University of Turin, Torino, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Biasibetti
authors.affiliation: Department of Veterinary Sciences, University of Turin, Torino, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Sferra
authors.affiliation: Veterinary Services Professionals LTD, Arusha, United Republic of Tanzania (URT).
authors.forename: Godelieve
authors.initials: G
authors.lastname: Lynen
authors.affiliation: Veterinary Services Professionals LTD, Arusha, United Republic of Tanzania (URT).
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Giulio
authors.affiliation: Department of Veterinary Sciences, University of Turin, Torino, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: De Meneghi
authors.affiliation: Department of Veterinary Sciences, University of Turin, Torino, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Tomassone
authors.affiliation: Department of Veterinary Sciences, University of Turin, Torino, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Valenza
authors.affiliation: Department of Veterinary Sciences, University of Turin, Torino, Italy. mariateresa.capucchio@unito.it.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Capucchio
mesh_terms: D000818:Animals; D002417:Cattle; D003937:Diagnosis, Differential; D005260:Female; D013636:Tanzania; D016794:Theileria / Q000302:isolation & purification*; D013801:Theileriasis / Q000175:diagnosis*; D013984:Tick Infestations / Q000175:diagnosis / Q000662:veterinary; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000662:veterinary
keywords: Brain; East-African short-horned Zebu; Histopathology; Immunopathology Theileria