title: Haploidentical transplant for myelodysplastic syndrome: registry-based comparison with identical sibling transplant.
abstract: Encouraging results from a small sample of patients with myelodysplastic syndrome (MDS) undergoing haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) must be extended. Furthermore, an algorithm derived from a comparison of the outcomes of HID and identical-sibling donor (ISD) HSCT must be established. Therefore, the outcomes of 454 MDS patients who underwent HSCT from HIDs (n=226) or ISDs (n=228) between 2003 and 2013 that were reported to the Chinese Bone Marrow Transplantation Registry were analyzed. Among the 3/6 HID (n=136), 4-5/6 HID (n=90) and ISD patient groups, the 4-year adjusted cumulative incidences of non-relapse mortality were 34, 29 and 16%, respectively (overall P=0.004), and of relapse were 6, 7 and 10%, respectively (overall P=0.36). The 4-year adjusted probabilities of overall survival were 58, 63 and 73%, respectively (overall P=0.07), and of relapse-free-survival were 58, 63 and 71%, respectively (overall P=0.14); pairwise comparison showed that the difference was only statistically significant in the 3/6 HID vs ISD pair. The data suggest that ISDs remain the best donor source for MDS patients while HIDs (perhaps 4-5/6 HID in particular) could be a valid alternative when an ISD is not available; human leukocyte antigen disparity had no effect on survival among the HID patients.
authors.affiliation: Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Air Force General Hospital, PLA, Beijing, China.
authors.forename: H-X
authors.initials: HX
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Y-R
authors.initials: YR
authors.lastname: Lai
authors.affiliation: Anhui Provincial Hospital, Hefei, Anhui, China.
authors.forename: Z-M
authors.initials: ZM
authors.lastname: Sun
authors.affiliation: The first affiliated hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: D-P
authors.initials: DP
authors.lastname: Wu
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Xinjiang Medical University, Wulumuqi, Xinjiang, China.
authors.forename: M
authors.initials: M
authors.lastname: Jiang
authors.affiliation: PLA General Hospital, Beijing, China.
authors.forename: D-H
authors.initials: DH
authors.lastname: Liu
authors.affiliation: The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: K-L
authors.initials: KL
authors.lastname: Xu
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Q-F
authors.initials: QF
authors.lastname: Liu
authors.affiliation: The first Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.affiliation: Aero Center Space Hospital, Beijing, China.
authors.forename: J-B
authors.initials: JB
authors.lastname: Wang
authors.affiliation: The Affiliated Hospital of North China University Science and Technology, Tangshan, Hebei, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
authors.forename: J
authors.initials: J
authors.lastname: Ou-Yang
authors.affiliation: The First Affiliated Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Gao
authors.affiliation: Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
authors.forename: L-P
authors.initials: LP
authors.lastname: Xu
authors.affiliation: Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.|Peking-Tsinghua Center for Life Sciences, Beijing, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006680:HLA Antigens / Q000494:pharmacology; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006648:Histocompatibility / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000401:mortality / Q000628:therapy*; D012008:Recurrence; D012042:Registries; D035781:Siblings; D015996:Survival Rate; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D006680:HLA Antigens