title: Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia.
abstract: BACKGROUND
  Alterations in serum adipokines in preeclampsia remain vague. We investigated the roles of leptin, adiponectin and resistin and their relationships with clinical characteristics in normotensive and preeclamptic patients.
  
  
  METHODS
  A case-control study was carried out in a cohort of 74 preeclampsia(PE) and 79 healthy pregnant women. Serum levels of leptin, adiponectin and resistin were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The mean body mass index(BMI), the serum leptin and resistin levels were significantly higher in the PE group than in the control group (p<0.001). The resistin/creatinine ratio was also higher in the PE group than in the control group (p=0.018). No significant difference was observed in the serum adiponectin level between both groups. Serum leptin levels were positively correlated with BMI (r=0.301, p<0.001) and negatively correlated with newborn birth weight (r=-0.435, p<0.001). Serum resistin levels were also negatively correlated with birth weight (r=-0.229, p=0.005) but were unrelated to BMI. Logistic regression showed that BMI≥28 and serum leptin levels were independent factors of PE. Leptin was a potential mediator between BMI and PE (p<0.001), and the mediating effect accounted for 22.54% of the total effect.
  
  
  CONCLUSIONS
  Leptin, resistin, and obesity play important roles in the onset of PE. Leptin and resistin may have some impacts on the fetal growth and development.
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, PR China.
authors.forename: Yingna
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, PR China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Gao
authors.affiliation: School of Public Health, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, PR China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, PR China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, PR China. Electronic address: juntao_liu@aliyun.com.
authors.forename: Juntao
authors.initials: J
authors.lastname: Liu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D052243:Resistin / Q000097:blood*
chemical_list: D052242:Adiponectin; D020738:Leptin; D052243:Resistin
keywords: Adiponectin; Body mass index; Leptin; Preeclampsia; Risistin