title: Physiologic Assessment of Coronary Artery Disease: Focus on Fractional Flow Reserve.
abstract: The presence of myocardial ischemia is the most important prognostic factor in patients with ischemic heart disease. Fractional flow reserve (FFR) is a gold standard invasive method used to detect the stenosis-specific myocardial ischemia. FFR-guided revascularization strategy is superior to angiography-guided strategy. The recently developed hyperemia-free index, instantaneous wave free ratio is being actively investigated. A non-invasive FFR derived from coronary CT angiography is now used in clinical practice. Due to rapid expansion of invasive and non-invasive physiologic assessment, comprehensive understanding of the role and potential pitfalls of each modality are required for its application. In this review, we focus on the basic and clinical aspects of physiologic assessment in ischemic heart disease.
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul 03080, Korea.
authors.forename: Doyeon
authors.initials: D
authors.lastname: Hwang
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
authors.forename: Joo Myung
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul 03080, Korea.; Institute of Aging, Seoul National University, Seoul 03087, Korea.
authors.forename: Bon-Kwon
authors.initials: BK
authors.lastname: Koo
mesh_terms: D017023:Coronary Angiography; D015444:Exercise; D053805:Fractional Flow Reserve, Myocardial / Q000502:physiology*; D006321:Heart / Q000000981:diagnostic imaging; D006439:Hemodynamics; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013312:Stress, Physiological; D014057:Tomography, X-Ray Computed
keywords: Coronary artery disease; Fractional flow reserve; Ischemia; Physiology