title: Fusiform dilatation of the internal carotid artery in childhood-onset craniopharyngioma: multicenter study on incidence and long-term outcome.
abstract: OBJECTIVE
  Fusiform dilatations of the internal carotid artery (FDCA) represent a vascular complication following surgery for suprasellar tumors in children. Incidence rate and long-term prognosis of FDCA in terms of survival rates, vascular complications, and quality of survival are unknown for patients with childhood-onset craniopharyngioma.
  
  
  METHODS
  Magnetic resonance imaging (MRI) results of 583 patients with childhood-onset craniopharyngioma, recruited from 2001 to 2015 in the German Childhood Craniopharyngioma Registry, were reviewed for FDCA. Risk factors for FDCA and long-term outcome after FDCA were analyzed.
  
  
  RESULTS
  Fourteen of 583 patients (2.4 %) developed FDCA based on reference assessment of MRI. FDCA occurred ipsilateral to the surgical approach and was not related to degree of resection, hypothalamic involvement, or irradiation. The median time interval between first detection of FDCA and initial surgery was 0.79 years (range 0.01-5.56 years). During a median follow-up of 6.47 years (range 1.2-21.9 years) after first detection of FDCA, no bleeding or cerebrovascular events were observed in any patient. Irradiation was not related to FDCA. Survival rates and functional capacity were similar in patients with and without FDCA. Clinically the FDCA was unapparent in all cases and not treated.
  
  
  CONCLUSIONS
  FDCA is a rare complication related to surgical treatment of childhood-onset craniopharyngioma without major impact on prognosis and clinical course of the disease.
  
  
  BACKGROUND
  KRANIOPHARYNGEOM 2000-NCT00258453; KRANIOPHARYNGEOM 2007-NCT01272622.
authors.affiliation: Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany.
authors.forename: Anika
authors.initials: A
authors.lastname: Hoffmann
authors.affiliation: Department of Neuroradiology, University Hospital, Würzburg, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Warmuth-Metz
authors.affiliation: Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany.
authors.forename: Kristin
authors.initials: K
authors.lastname: Lohle
authors.affiliation: Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Reichel
authors.affiliation: Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany.|University of Groningen, Groningen, The Netherlands.
authors.forename: Anna M M
authors.initials: AM
authors.lastname: Daubenbüchel
authors.affiliation: Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany.|University of Groningen, Groningen, The Netherlands.
authors.forename: Anthe S
authors.initials: AS
authors.lastname: Sterkenburg
authors.affiliation: Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany. mueller.hermann@klinikum-oldenburg.de.
authors.forename: Hermann L
authors.initials: HL
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000783:Aneurysm / Q000000981:diagnostic imaging / Q000453:epidemiology*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000453:epidemiology*
keywords: Aneurysm; Carotid artery; Children; Craniopharyngioma; Surgery; Survival