title: Infections after keratoprosthesis.
abstract: OBJECTIVE
  The purpose is to provide an overview of the recent advancements in the diagnosis and treatment of microbial keratitis and endophthalmitis after keratoprosthesis implantation.
  
  
  RESULTS
  The addition of vancomycin daily to a fluoroquinolone in the postoperative management of keratoprosthesis patients successfully reduced the number of cases of bacterial keratitis and endophthalmitis with an increased number of fungal infections now documented both in the United States and abroad.
  
  
  CONCLUSIONS
  Compliance with the regimen of a fluoroquinolone and vancomycin daily for life after keratoprosthesis implantation should be stressed with the patient. Further research is needed to investigate whether intermittent use of 5% povidone-iodine and frequent replacement of the bandage contact lens could reduce fungal infection after keratoprosthesis surgery. Future advancements in the Boston keratoprosthesis design and/or postoperative management are needed to further reduce infection after keratoprosthesis placement.
authors.affiliation: Cornea and External Disease Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Emma
authors.initials: E
authors.lastname: Davies
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001187:Artificial Organs; D003315:Cornea / Q000601:surgery; D009877:Endophthalmitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011183:Postoperative Complications / Q000382:microbiology*; D019736:Prostheses and Implants / Q000009:adverse effects*; D019919:Prosthesis Implantation / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents