title: Naphthalimide derived fluorescent probes with turn-on response for Au(3+) and the application for biological visualization.
abstract: The 4-N,N-dimethyl-1,8-naphthalimide based fluorescent probes have been explored for selective detection of Au(3+). Both probes show a pronounced fluorescence enhancement response to Au(3+). Hydroxy is introduced as ligand of Au(3+) for Probe 1 and the newly designed Probe 2 contains an alkyne moiety to recognize Au(3+) through an irreversible C≡C bond hydrolysis reaction. Probe 1 exhibits higher performance such as faster response, lower detection limit of 0.050μM and the better responsive effect in 99.5% water system compared with most of probes published. The Probe 2 displays high stability to pH, suitable water solubility, wider linear range (0-100μM) to Au(3+), and live-cells imaging with low cytotoxicity.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Jianjian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address: zhanghx@lzu.edu.cn.
authors.forename: Haixia
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods; D002412:Cations / Q000032:analysis; D002460:Cell Line; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D057230:Limit of Detection; D018613:Microscopy, Confocal / Q000379:methods; D053644:Naphthalimides / Q000737:chemistry*; D061848:Optical Imaging / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D000480:Alkynes; D002412:Cations; D005456:Fluorescent Dyes; D053644:Naphthalimides; D006046:Gold
keywords: Aqueous media; Au(3+); Biological visualization; Fluorescent Probe; Naphthalimide