title: Pulmonary Nocardiosis Caused by Nocardia concava with a Literature Review.
abstract: A 68-year-old man was admitted to our hospital with anorexia and leg pain. He was diagnosed with ANCA-associated vasculitis through a renal biopsy. Immunosuppression with two courses of steroid pulse therapies and intravenous cyclophosphamide followed by oral prednisolone at 40 mg/day were administered. About one month after starting the immunosuppression therapy, he complained of hemosputum. Chest computed tomography showed a cavitary lesion in the lung. Cultures from his sputum showed Nocardia species, and we were able to identify the species as N. concava using a 16S rRNA gene sequence analysis. Only three detailed reports of N. concava infection have so far been published worldwide.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University Hospital, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Hirayama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takazono
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Masato
authors.initials: M
authors.lastname: Tashiro
authors.forename: Tomomi
authors.initials: T
authors.lastname: Saijo
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kosai
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Morinaga
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kurihara
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Imamura
authors.forename: Taiga
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Misuzu
authors.initials: M
authors.lastname: Tsukamoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008168:Lung / Q000473:pathology; D008297:Male; D009617:Nocardia Infections / Q000175:diagnosis*; D011239:Prednisolone; D012336:RNA, Ribosomal, 16S; D013183:Sputum; D014057:Tomography, X-Ray Computed / Q000009:adverse effects
chemical_list: D007166:Immunosuppressive Agents; D012336:RNA, Ribosomal, 16S; D011239:Prednisolone