title: RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.
abstract: RNA helicases, which unwind RNAs, are essential for RNA metabolism and homeostasis. However, the roles of RNA helicases in specific physiological processes remain poorly understood. We recently reported that an RNA helicase, HEL-1, promotes long lifespan conferred by reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) in Caenorhabditis elegans. We also showed that HEL-1 induces the expression of longevity genes by physically interacting with Forkhead box O (FOXO) transcription factor. Thus, the HEL-1 RNA helicase appears to regulate lifespan by specifically activating FOXO in IIS. In the current study, we report another longevity-promoting RNA helicase, Suppressor of ACY-4 sterility 1 (SACY-1). SACY-1 contributed to the longevity of daf-2/insulin/IGF-1 receptor mutants. Unlike HEL-1, SACY-1 was also required for the longevity due to mutations in genes involved in non-IIS pathways. Thus, SACY-1 appears to function as a general longevity factor for various signaling pathways, which is different from the specific function of HEL-1.
authors.affiliation: a Department of Life Sciences , Pohang University of Science and Technology , Pohang , Korea.
authors.forename: Mihwa
authors.initials: M
authors.lastname: Seo
authors.affiliation: a Department of Life Sciences , Pohang University of Science and Technology , Pohang , Korea.
authors.forename: Sangsoon
authors.initials: S
authors.lastname: Park
authors.affiliation: d Center for Plant Aging Research, Institute for Basic Science, DGIST , Daegu , Korea.|e Department of New Biology , DGIST , Daegu , Korea.
authors.forename: Hong Gil
authors.initials: HG
authors.lastname: Nam
authors.affiliation: a Department of Life Sciences , Pohang University of Science and Technology , Pohang , Korea.|b School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology , Pohang , Korea.|c Information Technology Convergence Engineering, Pohang University of Science and Technology , Pohang , Korea.
authors.forename: Seung-Jae V
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000378:metabolism*; D053487:DEAD-box RNA Helicases / Q000737:chemistry / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D008136:Longevity / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D012098:Reproduction; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D029742:Caenorhabditis elegans Proteins; D007328:Insulin; D017526:Receptor, IGF Type 1; C580571:SACY-1 protein, C elegans; D053487:DEAD-box RNA Helicases
keywords: Aging; C. elegans; HEL-1; RNA helicase; SACY-1; daf-2; insulin/IGF-1 signaling