title: Polymeric Framboidal Nanoparticles Loaded with a Carbon Monoxide Donor via Phenylboronic Acid-Catechol Complexation.
abstract: Carbon monoxide (CO) is an essential gaseous signaling molecule in the human body. Toward the controlled delivery of CO to the target tissues or cells, nanomaterial-based CO donors have attracted growing attention. Here, we present CO-releasing polymeric nanoparticles (CONPs) prepared by simple mixing of phenylboronic acid-containing framboidal nanoparticles with the catechol-bearing CO-donor Ru(CO)3Cl(L-DOPA) via phenylboronic acid-catechol complexation. The CONPs release CO in response to cysteine and suppress the production of the pro-inflammatory mediators interleukin 6 (IL-6) and nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophages. This CONP platform may show promise in therapeutic applications of CO.
authors.affiliation: Frontier Research Center, Graduate School of Engineering, ‡Department of Applied Chemistry, Graduate School of Engineering, and §Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: André J
authors.initials: AJ
authors.lastname: van der Vlies
authors.affiliation: Frontier Research Center, Graduate School of Engineering, ‡Department of Applied Chemistry, Graduate School of Engineering, and §Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Inubushi
authors.affiliation: Frontier Research Center, Graduate School of Engineering, ‡Department of Applied Chemistry, Graduate School of Engineering, and §Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uyama
authors.affiliation: Frontier Research Center, Graduate School of Engineering, ‡Department of Applied Chemistry, Graduate School of Engineering, and §Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Urara
authors.initials: U
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D001692:Biological Transport; D001897:Boronic Acids / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D000067996:RAW 264.7 Cells
chemical_list: D000893:Anti-Inflammatory Agents; D001897:Boronic Acids; D002396:Catechols; D008070:Lipopolysaccharides; D009942:Organometallic Compounds; D011108:Polymers; D002248:Carbon Monoxide; C010686:benzeneboronic acid; C034221:catechol