title: Off-label Use of Tocilizumab in Psoriatic Arthritis: Case Series and Review of the Literature.
abstract: OBJECTIVE
  To evaluate the efficacy of tocilizumab (TCZ) on three patients with psoriatic arthritis (PsA) and review the literature for other cases of PsA treated with TCZ.
  
  
  METHODS
  The first patient started TCZ treatment after the failure of adalimumab (ADA), and etanercept (ETA) (Disease Activity Score, DAS28: 6.66) to treat PsA. After 12 months, her DAS28 decreased to 3.26, and at present (24 months), she has achieved disease remission. The second patient started TCZ treatment after the failure of ADA. After 12 months, the DAS28 decreased from 4.90 to 3.99. After 48 months of treatment, the patient had a DAS28 of 3.76. The third case was treated with TCZ after the failure of both infliximab and rituximab therapy. After 12 months, the DAS28 dropped from 8.65 to 5.49. At present, after 37 months of treatment, the patient has a DAS28 of 4.67. In the literature, there are six cases of PsA, which have been treated with TCZ: in two of the cases, the patient showed a great improvement. Two cases failed to achieve disease remission, despite a moderate response to the treatment, and the other two cases showed no improvement.
  
  
  CONCLUSIONS
  It can be concluded that TCZ cannot be recommended as an alternative treatment for PsA with predominant peripheral involvement.
authors.forename: P
authors.initials: P
authors.lastname: Madureira
authors.forename: S S
authors.initials: SS
authors.lastname: Pimenta
authors.forename: A
authors.initials: A
authors.lastname: Bernardo
authors.forename: J S
authors.initials: JS
authors.lastname: Brito
authors.forename: M
authors.initials: M
authors.lastname: Bernardes
authors.forename: L
authors.initials: L
authors.lastname: Costa
mesh_terms: D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D056687:Off-Label Use; D012074:Remission Induction
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C502936:tocilizumab