title: Polymorphisms of the Stem Cell Marker Gene CD133 and the Risk of Lung Cancer in Chinese Population.
abstract: To explore the association of functional single-nucleotide polymorphisms (SNPs) of CD133 with the risk of lung cancer.
  
  
  
  We conducted a hospital-based, case-control study of 1017 lung cancer patients and 1035 cancer-free controls frequency-matched by age and sex. Four functional CD133 SNPs (rs2240688 A > C, rs10022537 T > A, rs7686732 C > G, and rs3130 C > T) were selected and genotyped. Unconditional univariate and multivariate logistic regression analyses were carried out to evaluate the associations of genotypes of CD133 SNPs with lung cancer risk.
  
  
  
  Compared with rs2240688 AA genotype, the variant AC/CC genotypes were associated with a statistically increased risk of lung cancer under a recessive model (adjusted odds ratio 1.19; 95 % confidence interval 1.01-1.42). The risk remained in patients with other histology types, but not with adenocarcinoma and squamous cell cancers.
  
  
  
  These findings suggest that SNP rs2240688 A > C of CD133 may be a potential biomarker for genetic susceptibility to lung cancer, but require further research with larger populations.
authors.affiliation: Department of Thoracic Surgery, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), 7 Weiwu Street, Zhengzhou, 450003, Henan, People's Republic of China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), 7 Weiwu Street, Zhengzhou, 450003, Henan, People's Republic of China.
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), 7 Weiwu Street, Zhengzhou, 450003, Henan, People's Republic of China.
authors.forename: Guang-Jie
authors.initials: GJ
authors.lastname: Hou
authors.affiliation: Department of Thoracic Surgery, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), 7 Weiwu Street, Zhengzhou, 450003, Henan, People's Republic of China.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), 7 Weiwu Street, Zhengzhou, 450003, Henan, People's Republic of China. 13903866310@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: He
mesh_terms: D000071916:AC133 Antigen / Q000235:genetics*; D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D000071916:AC133 Antigen; D014408:Biomarkers, Tumor
keywords: CD133 polymorphism; China; Genetic susceptibility; Lung cancer