title: [Pregnancy in systemic autoimmune diseases: Myths, certainties and doubts].
abstract: Systemic autoimmune diseases especially affect young women during childbearing age. The aim of this review is to update systemic lupus erythematosus, antiphospholipid syndrome and systemic sclerosis management during pregnancy. These diseases present variable maternal and fetal risks. Studies show that an appropriate disease control and a reasonable remission period prior to pregnancy are associated with satisfactory obstetric outcomes. Antiphospholipid autoantibodies profile, anti-Ro/anti-La antibodies, pulmonary pressure and activity evaluation are crucial to assess the pregnancy risk. Monitoring requires a multidisciplinary team, serial analytic controls and Doppler ultrasound of maternal and fetal circulation. Evaluation of the activity of the disease is essential.
authors.affiliation: Unidad Docente Asistencial en Enfermedades Autoinmunes Sistémicas y Reumatológicas, Clínica Médica, Hospital Pasteur, Departamento de Medicina, Facultad de Medicina, Universidad de la República, Administración de Servicios de Salud del Estado (ASSE), Montevideo, Uruguay; Unidad de Investigación de Enfermedades Autoinmunes, Servicio de Medicina Interna, BioCruces Health Research Institute, Hospital Universitario Cruces, Universidad del País Vasco (UPV)/Euskal Herriko Unibertsitatea (EHU), Barakaldo, Vizcaya, España. Electronic address: alvarodanza@gmail.com.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Danza
authors.affiliation: Unidad de Investigación de Enfermedades Autoinmunes, Servicio de Medicina Interna, BioCruces Health Research Institute, Hospital Universitario Cruces, Universidad del País Vasco (UPV)/Euskal Herriko Unibertsitatea (EHU), Barakaldo, Vizcaya, España.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Ruiz-Irastorza
authors.affiliation: Lupus Research Unit, St Thomas' Hospital, Londres, Reino Unido.
authors.forename: Munther
authors.initials: M
authors.lastname: Khamashta
mesh_terms: D016736:Antiphospholipid Syndrome / Q000628:therapy*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*; D018743:Perinatal Care / Q000379:methods*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods*; D012595:Scleroderma, Systemic / Q000628:therapy*; D035501:Uncertainty
keywords: Antiphospholipid syndrome; Complicaciones fetales; Complicaciones maternas; Complications in pregnancy; Embarazo; Esclerosis sistémica; Fetal outcome; Lupus eritematoso sistémico; Maternal outcome; Pregnancy; Resultados obstétricos; Systemic lupus erythematosus; Systemic sclerosis; Síndrome antifosfolípido