title: Effect of basal insulin therapy on vascular endothelial function and adipokine profiles in people with Type 2 diabetes.
abstract: To compare the effects of the basal insulin analogues glargine and detemir on endothelial function and adipocytokine levels in people with Type 2 diabetes.
  
  
  
  We studied 32 people with Type 2 diabetes whose blood glucose control was unsatisfactory while receiving only oral hypoglycaemic drugs. Participants were randomized to either insulin glargine or detemir for 24 weeks and then crossed over to the other treatment without a washout period. Flow-mediated vasodilatation, adipocytokine levels (plasminogen activator inhibitor-1 and leptin/adiponectin ratio), and fasting ghrelin levels were monitored.
  
  
  
  HbA1clevels were significantly decreased by both basal insulin therapies. Body weight was significantly increased by glargine but not by detemir. The proportion of flow-mediated vasodilatation was significantly increased by detemir but not glargine (glargine: from 5.17 ± 0.69 to 5.94 ± 0.83%; detemir: from 4.89 ± 0.78 to 7.92 ± 0.69%). Plasminogen activator inhibitor-1 level was significantly decreased by only detemir (glargine: from 16.4 ± 1.8 to 17.3 ± 2.1; detemir: from 19.2 ± 2.8 to 16.0 ± 1.6 ng/ml). The leptin/adiponectin ratio was significantly increased only by glargine. Acyl ghrelin level was significantly decreased by glargine but not detemir.
  
  
  
  These results suggest that the effect on endothelial function and adipocytokine profiles may differ between glargine and detemir in people with diabetes (Trial registration ID: UMIN000004973).
authors.affiliation: Division of Atherosclerosis and Diabetes, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.affiliation: Division of Atherosclerosis and Diabetes, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: National Cerebral and Cardiovascular Centre Research Institute, Suita, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hosoda
authors.affiliation: Division of Atherosclerosis and Diabetes, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Koezuka
authors.affiliation: Division of Atherosclerosis and Diabetes, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tochiya
authors.affiliation: Division of Atherosclerosis and Diabetes, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohata
authors.affiliation: Division of Atherosclerosis and Diabetes, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tamanaha
authors.affiliation: Division of Preventive Cardiology, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Kangawa
authors.affiliation: Division of Atherosclerosis and Diabetes, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kishimoto
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D002097:C-Reactive Protein / Q000378:metabolism; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005260:Female; D054439:Ghrelin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D000069057:Insulin Detemir / Q000627:therapeutic use*; D000069036:Insulin Glargine / Q000627:therapeutic use*; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D054439:Ghrelin; D007004:Hypoglycemic Agents; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; D000069036:Insulin Glargine; D000069057:Insulin Detemir; D002097:C-Reactive Protein