title: Psychological Issues Associated With Absolute Uterine Factor Infertility and Attitudes of Patients Toward Uterine Transplantation.
abstract: BACKGROUND
  Uterine transplantation (UTx).
  
  
  OBJECTIVE
  To explore patients' knowledge of and attitudes toward UTx before and after a short educational intervention via a video and question and answer (Q&A) session.
  
  
  METHODS
  Large, in-depth survey investigating patients' motivations, aims, and beliefs on UTx.
  
  
  METHODS
  Imperial College London.
  
  
  METHODS
  Women diagnosed with absolute uterine factor infertility (AUFI) who were seeking information on UTx and had already volunteered to participate in the study.
  
  
  METHODS
  A semistructured interview involving a brief baseline questionnaire before a Q&A session and a 20-minute video exploring the main risks and benefits for UTx.
  
  
  METHODS
  Attitudes of self-referred patients with AUFI toward UTx before and after education focusing on UTx. Rank order of importance of key UTx-related issues.
  
  
  RESULTS
  Forty women were interviewed. Following the video presentation and Q&A session, 97.5% (n = 39) would undergo UTx ahead of surrogacy and adoption in full knowledge that the latter 2 options would be ultimately safer for their own well-being and the fact that the graft could fail even prior to conception. All felt that UTx should take place, and 92.5% saw UTx as achievable.
  
  
  CONCLUSIONS
  The study demonstrates a keen interest in UTx, partly because other options seem difficult to access. It is worth noting that people appear to be distancing themselves from the risk. This requires careful assessment in any clinical program. This study is the first to demonstrate a qualitative relationship between patients with AUFI and their curiosity and desire for UTx. It paves the way for forming the introduction into the psychological assessment of a potential patient.
authors.affiliation: Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, London, United Kingdom srdjan.saso@imperial.ac.uk.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Saso
authors.affiliation: Department of Plastic and Reconstructive Surgery, Royal Free London, NHS Foundation Trust, London, United Kingdom.
authors.forename: Alex
authors.initials: A
authors.lastname: Clarke
authors.affiliation: William Harvey Hospital, Ashford, Kent, United Kingdom.
authors.forename: Timothy
authors.initials: T
authors.lastname: Bracewell-Milnes
authors.affiliation: St Mary's Hospital, Imperial College London, London, United Kingdom.
authors.forename: Anja
authors.initials: A
authors.lastname: Saso
authors.affiliation: Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, London, United Kingdom.
authors.forename: Maya
authors.initials: M
authors.lastname: Al-Memar
authors.affiliation: The Lister Hospital, Chelsea, London, United Kingdom.
authors.forename: Meen-Yau
authors.initials: MY
authors.lastname: Thum
authors.affiliation: West London Gynaecological Cancer Centre, Queen Charlotte's Hospital, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom.
authors.forename: Joseph
authors.initials: J
authors.lastname: Yazbek
authors.affiliation: Indiana University, Indianapolis, IN, USA.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Del Priore
authors.affiliation: Institute for Women's Health, University College London, London, United Kingdom Royal Free, University College and Whittington NHS Trusts, London, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Hardiman
authors.affiliation: Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.
authors.forename: Sadaf
authors.initials: S
authors.lastname: Ghaem-Maghami
authors.affiliation: West London Gynaecological Cancer Centre, Queen Charlotte's Hospital, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom.
authors.forename: J Richard
authors.initials: JR
authors.lastname: Smith
mesh_terms: D058489:46, XX Disorders of Sex Development / Q000150:complications / Q000523:psychology / Q000601:surgery; D000328:Adult; D000013:Congenital Abnormalities / Q000523:psychology / Q000601:surgery; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007044:Hysterectomy; D007247:Infertility, Female / Q000209:etiology / Q000523:psychology* / Q000601:surgery; D008875:Middle Aged; D009095:Mullerian Ducts / Q000002:abnormalities / Q000601:surgery; D016377:Organ Transplantation / Q000523:psychology*; D006113:United Kingdom; D014591:Uterine Diseases / Q000523:psychology* / Q000601:surgery; D014599:Uterus / Q000637:transplantation*; D055815:Young Adult
keywords: fertility; health-care professionals; survey; transplantation; uterus