title: Impact of tissue T1on perfusion measurement with arterial spin labeling.
abstract: Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T1on CBF quantification using ASL.
  
  
  
  To locally modify T1, a low dose of manganese (Mn) was intracerebrally injected in one hemisphere of 19 rats (cortex or striatum). Tissue T1and CBF were mapped using inversion recovery and continuous ASL experiments at 4.7T.
  
  
  
  Mn reduced the tissue T1by more than 30% but had little impact on other tissue properties as assessed via dynamic susceptibility and diffusion MRI. Using a single-compartment model, the use of a single tissue T1value yielded a mean relative ipsilateral (Mn-injected) to contralateral (noninjected) CBF difference of -34% in cortex and -22% in striatum tissue. With a T1map, these values became -7% and +8%, respectively.
  
  
  
  A low dose of Mn reduces the tissue T1without modifying CBF. Heterogeneous T1impacts the ASL estimate of CBF in a region-dependent way. In animals, and when T1modifications exceed the accuracy with which the tissue T1can be determined, an estimate of tissue T1should be obtained when quantifying CBF with an ASL technique. Magn Reson Med 77:1656-1664, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: INSERM U1216, Grenoble, France.|Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.|Bruker BioSpin MRI, Ettligen, Germany.
authors.forename: Clément S
authors.initials: CS
authors.lastname: Debacker
authors.affiliation: INSERM U1216, Grenoble, France.|Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.
authors.forename: Alexia
authors.initials: A
authors.lastname: Daoust
authors.affiliation: Bruker BioSpin MRI, Ettligen, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Köhler
authors.affiliation: Bruker BioSpin MRI, Ettligen, Germany.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Voiron
authors.affiliation: INSERM U1216, Grenoble, France.|Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.
authors.forename: Jan M
authors.initials: JM
authors.lastname: Warnking
authors.affiliation: INSERM U1216, Grenoble, France.|Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.
authors.forename: Emmanuel L
authors.initials: EL
authors.lastname: Barbier
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008345:Manganese / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D008345:Manganese
keywords: arterial spin labeling; cerebral blood flow; manganese; perfusion; quantification; rat