title: General Synthesis of Amino Acid Salts from Amino Alcohols and Basic Water Liberating H2.
abstract: An atom-economical and environmentally friendly method to transform amino alcohols to amino acid salts using just basic water, without the need of pre-protection or added oxidant, catalyzed by a ruthenium pincer complex, is developed. Water is the solvent, the source of the oxygen atom of the carboxylic acid group, and the actual oxidant, with liberation of dihydrogen. Many important and useful natural and unnatural amino acid salts can be produced in excellent yields by applying this new method.
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 76100, Israel.
authors.forename: Peng
authors.initials: P
authors.lastname: Hu
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 76100, Israel.
authors.forename: Yehoshoa
authors.initials: Y
authors.lastname: Ben-David
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 76100, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Milstein
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D000605:Amino Alcohols / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D055772:Green Chemistry Technology; D006859:Hydrogen / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis; D016877:Oxidants / Q000737:chemistry; D017975:Ruthenium Compounds / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D012997:Solvents; D014867:Water / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D000605:Amino Alcohols; D002264:Carboxylic Acids; D007769:Lactams; D016877:Oxidants; D017975:Ruthenium Compounds; D012492:Salts; D012997:Solvents; D014867:Water; D006859:Hydrogen