title: Field-enhanced sample injection micelle-to-solvent stacking capillary zone electrophoresis-electrospray ionization mass spectrometry of antibiotics in seawater after solid-phase extraction.
abstract: The synergistic stacking approach of field-enhanced sample injection-micelle-to-solvent stacking was used for high sensitivity CZE-ESI-MS of eight penicillins and sulfonamides. Sensitivity enhancement factors (peak height) were 1629-3328 compared to typical injection, with LODs from 0.11 to 0.55 ng/mL. The analytical figures of merit were acceptable. SPE on a fortified seawater sample resulted in 50-fold enrichment with recoveries of 85-110%. The overall method LODs were 0.002-0.011 ng/mL.
authors.affiliation: Australian Centre for Research on Separation Science, School of Physical Sciences-Chemistry, University of Tasmania, Tasmania, Australia.
authors.forename: Alain
authors.initials: A
authors.lastname: Wuethrich
authors.affiliation: Australian Centre for Research on Separation Science, School of Physical Sciences-Chemistry, University of Tasmania, Tasmania, Australia.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Haddad
authors.affiliation: Australian Centre for Research on Separation Science, School of Physical Sciences-Chemistry, University of Tasmania, Tasmania, Australia.
authors.forename: Joselito P
authors.initials: JP
authors.lastname: Quirino
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D057230:Limit of Detection; D016014:Linear Models; D015203:Reproducibility of Results; D012623:Seawater / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotics; Field-enhanced sample injection; MS; Micelle-to-solvent stacking; SPE