title: Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers.
abstract: Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning.
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Ajeet
authors.initials: A
authors.lastname: Kaushik
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Rahul D
authors.initials: RD
authors.lastname: Jayant
authors.affiliation: Department of Mechanical &Materials Engineering, College of Engineering and Computing, Florida International University, Miami, FL-33174, USA.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Nikkhah-Moshaie
authors.affiliation: Department of Chemistry &Physics, Western Carolina University, Cullowhee - NC-28723, USA.
authors.forename: Vinay
authors.initials: V
authors.lastname: Bhardwaj
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Upal
authors.initials: U
authors.lastname: Roy
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Zaohua
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Ariel
authors.initials: A
authors.lastname: Ruiz
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Adriana
authors.initials: A
authors.lastname: Yndart
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Venkata
authors.initials: V
authors.lastname: Atluri
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Nazira
authors.initials: N
authors.lastname: El-Hage
authors.affiliation: Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA-19140, USA.
authors.forename: Kamel
authors.initials: K
authors.lastname: Khalili
authors.affiliation: Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.
authors.forename: Madhavan
authors.initials: M
authors.lastname: Nair
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D060526:Magnetic Fields; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects*; D008810:Mice, Inbred C57BL
chemical_list: D004337:Drug Carriers