title: Neuroimaging for diagnosing dementia with Lewy bodies: What is the best neuroimaging technique in discriminating dementia with Lewy bodies from Alzheimer's disease?
abstract: OBJECTIVE
  We compared the diagnostic value of four neuroimaging techniques, namely,123I-2β-Carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) dopamine transporter single-photon emission computed tomography (DAT-SPECT), magnetic resonance imaging, perfusion SPECT and123I-metaiodobenzyl-guanidine myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD).
  
  
  METHODS
  A total of 32 patients with probable AD and 32 patients with probable DLB were enrolled in the present study. For the comparison study, we used the specific binding ratio for DAT-SPECT, the heart-to-mediastinum ratio in the delay phase for123I-metaiodobenzyl-guanidine myocardial scintigraphy, z-scores in the medial occipital lobe for perfusion SPECT and z-scores of hippocampal atrophy using a voxel-based specific regional analysis system for AD for magnetic resonance imaging.
  
  
  RESULTS
  DAT-SPECT enabled more accurate differentiation of DLB from AD than other methods.123I-metaiodobenzyl-guanidine myocardial scintigraphy enabled more accurate differentiation of DLB from AD than magnetic resonance imaging and perfusion SPECT.
  
  
  CONCLUSIONS
  In agreement with the recent consensus clinical diagnostic criteria for DLB, we confirmed that the diagnostic accuracy of DAT-SPECT imaging is significantly higher than other neuroimaging techniques. Geriatr Gerontol Int 2017; 17: 819-824.
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shimizu
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kanetaka
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hirao
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Raita
authors.initials: R
authors.lastname: Fukasawa
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Nayuta
authors.initials: N
authors.lastname: Namioka
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Hatanaka
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hirose
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Umahara
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sakurai
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Hanyu
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis*; D001921:Brain / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
keywords: 123I-metaiodobenzyl-guanidine myocardial scintigraphy; Alzheimer's diseasedementia with Lewy bodies; dopamine transporter; magnetic resonance imaging; single-photon emission computed tomography