title: Therapeutic failure with thalidomide in patients with recurrent intestinal bleeding due to angiodysplasias.
abstract: Angiodysplasias are one of the reasons of gastrointestinal bleeding, whose origin is usually due to vascular malformations. There are different types of therapies for angiodysplasia such as endoscopic, angiographic and pharmacological techniques. Among the last ones, there is little variety of effective drugs to treat the disease. We describe the therapeutic failure with thalidomide in a male with recurrent gastrointestinal bleeding due to angiodysplasias. A thorough diagnostic work-up, including gastroscopy, enteroscopy, angiography and capsule endoscopy were performed. Despite treatment with high-dose somatostatin analogues and oral iron, the patient continued bleeding. The patient was administered then thalidomide for three months with no clinical response. Thalidomide had to be withdrawn owing to adverse effects.
authors.affiliation: Pharmacy Department. Hospital Clínico Universitario de Valladolid. Valladolid. España.. mariaizquierdon@hotmail.com.
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Izquierdo Navarro
authors.affiliation: Pharmacy Department. Hospital Clínico Universitario de Valladolid. Valladolid. España.. mhernandov@saludcastillayleon.es.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Hernando Verdugo
authors.affiliation: Pharmacy Department. Hospital Clínico Universitario de Valladolid. Valladolid. España.. mcizquierdo@saludcastillayleon.es.
authors.forename: Elena
authors.initials: E
authors.lastname: Cardaba Garcia
authors.affiliation: Pharmacy Department. Hospital Clínico Universitario de Valladolid. Valladolid. España.. mtsanchezsa@saludcastillayleon.es.
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Sanchez Sanchez
mesh_terms: D000368:Aged; D000740:Anemia / Q000209:etiology; D016888:Angiodysplasia / Q000150:complications* / Q000188:drug therapy*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008551:Melena / Q000209:etiology; D013792:Thalidomide / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide