title: Facile Synthesis of Uniform-Sized Bismuth Nanoparticles for CT Visualization of Gastrointestinal Tract in Vivo.
abstract: High-performance and biocompatible contrast agents are the key to accurate diagnosis of various diseases in vivo via CT imaging. Fabrication of pure Bi nanoparticles is the best way to maximize X-ray absorption efficiency due to the ultrahigh X-ray attenuation ability of Bi and 100% content of Bi element. However, high-quality Bi nanoparticles prepared through a facile strategy are still lacking. Herein, we report a simple noninjection method to fabricate uniformly sized pure Bi nanoparticles using only two commercial reagents by simply heating the mixture of raw materials in a short time. The obtained Bi nanoparticles owned highly uniform size, excellent monodispersity, and impressive antioxidant capacity. After being modified with oligosaccharide, the "sweet" Bi nanoprobe with comfortable patient experience and favorable biocompatibility was successfully used in CT visualization of gastrointestinal tract in detail.
authors.affiliation: School of Medical Imaging, Tianjin Medical University , Tianjin 300203, China.
authors.forename: Boxiong
authors.initials: B
authors.lastname: Wei
authors.affiliation: School of Medical Imaging, Tianjin Medical University , Tianjin 300203, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital , Tianjin 300052, China.
authors.forename: Cai
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Medical Imaging, Tianjin Medical University , Tianjin 300203, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Medical Imaging, Tianjin Medical University , Tianjin 300203, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Fu
authors.affiliation: Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital , Tianjin 300052, China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
authors.affiliation: School of Medical Imaging, Tianjin Medical University , Tianjin 300203, China.
authors.forename: Shao-Kai
authors.initials: SK
authors.lastname: Sun
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , 94 Weijin Road, Tianjin 300071, China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Yan
mesh_terms: D001729:Bismuth / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis*; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D001729:Bismuth
keywords: Bi nanoparticles; CT imaging; gastrointestinal tract imaging; non hot-injection; uniform size