title: Tumor Characteristics, Genetics, Management, and the Risk of Metastasis in Uveal Melanoma.
abstract: Uveal melanoma is the most common intraocular malignancy in adults. Although rates of local control for uveal melanoma exceed 95% with radiotherapy or enucleation, as many as 50% of patients develop hematogenous metastases, which manifest in the decades following initial diagnosis and are uniformly and rapidly fatal. Recent compelling evidence suggests that not all uveal melanomas are themselves equivalent with respect to metastatic potential and patient survival. This review focuses on the mounting evidence of survival disparities based on intrinsic tumor clinical and histopathologic characteristics and based on tumor genetics and gene expression profiles.
authors.affiliation: a Department of Ophthalmology and Visual Sciences , Vanderbilt University Medical Center , Nashville , TN , USA.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Nichols
authors.affiliation: b Tennessee Valley Healthcare System , Department of Veterans Affairs , Nashville , TN , USA.|c Department of Cancer Biology , Vanderbilt University , Nashville , TN , USA.|d Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center , Nashville , TN , USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Richmond
authors.affiliation: a Department of Ophthalmology and Visual Sciences , Vanderbilt University Medical Center , Nashville , TN , USA.|c Department of Cancer Biology , Vanderbilt University , Nashville , TN , USA.|d Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center , Nashville , TN , USA.|e Department of Radiation Oncology , Vanderbilt University Medical Center , Nashville , TN , USA.
authors.forename: Anthony B
authors.initials: AB
authors.lastname: Daniels
mesh_terms: D054624:Health Status Disparities; D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D009362:Neoplasm Metastasis; D012307:Risk Factors; D015996:Survival Rate; D014604:Uveal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D000098943:Uveal Melanoma
keywords: Disparities; epidemiology; genetics; metastasis; ocular tumors; ophthalmology; prognosis; risk factors; survival; uveal melanoma