title: Anti-inflammatory Prenylated Flavonoids from Helminthostachys zeylanica.
abstract: Two new [neougonins A (1) and B (2)] and nine known prenylated flavonoids were isolated from the whole plants of Helminthostachys zeylanica. The structures of the new isolates were elucidated by extensive NMR techniques, including one and two dimensional (1D)- and (2D)-NMR experiments, as well as comparison with spectroscopic data of known analogous compounds. Moreover, compound 1 inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with an IC50 value of 3.32 µM.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Su
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Li
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Dai
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Lang
authors.initials: L
authors.lastname: Cao
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D029624:Ferns / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D054876:Prenylation; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D008070:Lipopolysaccharides; C000613627:neougonin A; C000613628:neougonin B; D009569:Nitric Oxide