title: A Case of Patch Stage of Kaposi's Sarcoma and Discussion of the Differential Diagnosis.
abstract: A 55 year old HIV positive male had a skin lesion biopsy which showed atypical vascular proliferation within the superficial and deep dermis with mild atypia of lining endothelial cells. A sparse lymphoplasmacytic infiltrate surrounding the irregular vascular channels was noted. Immunohistochemistry highlighted the atypical blood vessels with the vascular markers CD31, CD34 and Factor VIII. The differential diagnosis included unusual vascular or lymphatic proliferations, stasis dermatitis, kaposiform hemangioendothelioma, progressive lymphangioma and angiosarcoma with focal Kaposi's sarcoma features. Characteristic human herpes virus-8 positive staining helped support the diagnosis of patch stage of Kaposi's sarcoma. Herein, we discuss the case findings, differential diagnosis and characteristic histological findings associated with the patch stage of Kaposi's sarcoma which can be an elusive diagnosis.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University , Hamilton, ON, Canada.
authors.forename: Ipshita
authors.initials: I
authors.lastname: Kak
authors.affiliation: Department of Pathology and Molecular Medicine, St. Joseph's Healthcare Hamilton, ON, Canada.
authors.forename: Samih
authors.initials: S
authors.lastname: Salama
authors.affiliation: Department of Pathology and Molecular Medicine, St. Joseph's Healthcare Hamilton, ON, Canada.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Gohla
authors.affiliation: Department of Pathology and Molecular Medicine, St. Joseph's Healthcare Hamilton, ON, Canada.
authors.forename: Asghar
authors.initials: A
authors.lastname: Naqvi
authors.affiliation: Department of Pathology and Molecular Medicine, St. Joseph's Healthcare Hamilton, ON, Canada.
authors.forename: Salem
authors.initials: S
authors.lastname: Alowami
keywords: Kaposi’s sarcoma; human herpes virus-8; patch stage