title: Molecular Imaging of Ovarian Cancer.
abstract: Ovarian cancer is the most lethal gynecologic malignancy and the fifth leading cause of cancer-related death in women. Over the past decade, medical imaging has played an increasingly valuable role in the diagnosis, staging, and treatment planning of the disease. In this "Focus on Molecular Imaging" review, we seek to provide a brief yet informative survey of the current state of the molecular imaging of ovarian cancer. The article is divided into sections according to modality, covering recent advances in the MR, PET, SPECT, ultrasound, and optical imaging of ovarian cancer. Although primary emphasis is given to clinical studies, preclinical investigations that are particularly innovative and promising are discussed as well. Ultimately, we are hopeful that the combination of technologic innovations, novel imaging probes, and further integration of imaging into clinical protocols will lead to significant improvements in the survival rate for ovarian cancer.
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Sai Kiran
authors.initials: SK
authors.lastname: Sharma
authors.affiliation: Tri-Institutional MD-PhD Program, New York, New York Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Brandon
authors.initials: B
authors.lastname: Nemieboka
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York Departments of Radiology and Pharmacology, Weill Cornell Medical College, New York, New York.
authors.forename: Evis
authors.initials: E
authors.lastname: Sala
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York Departments of Radiology and Pharmacology, Weill Cornell Medical College, New York, New York.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Lewis
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York Departments of Radiology and Pharmacology, Weill Cornell Medical College, New York, New York Department of Chemistry, Hunter College of City University of New York, New York, New York; and Graduate Center of City University of New York, New York, New York bz102@hunter.cuny.edu.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Zeglis
mesh_terms: D005260:Female; D006801:Humans; D057054:Molecular Imaging; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
keywords: MRI; PET; SPECT; molecular imaging; ovarian cancer; ultrasound