title: Allergen immunotherapy in polysensitized patient.
abstract: Specific allergen immunotherapy (AIT) is the only therapeutic method with positive impact on natural course of allergic disease - affecting clinical development (including the progression of rhinitis to asthma) and new sensitisations. The actual problem is the increasing number of patients manifesting poly-sensitivity in allergy skin tests and / or in specific IgE tests. Usually, AIT is not recommended in such individuals. The objective we are facing is that in many patients tested as poly-reactive, we have to distinguish in which cases it is a true polysensitization, and when it is due to cross-reactivity of specific IgE antibodies induced by panallergens. This may really determine when AIT may be an appropriate course of action. The article focuses on this problem in more detail, applying the long time Czech and Slovak experience with allergy testing and allergen immunotherapy.
authors.affiliation: Dept. Allergy & Clinical Immunology, Oncology Institute St. Elisabeth, Batislava, Slovakia. OKIA OÚSA, Heydukova 10 85103 Batislava, Slovakia Phone: +42 190 34 16 121 E-mail: martin.hrubisko@ousa.sk; mahrubisko@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Hrubiško
authors.affiliation: Immuno-Flow, Praha, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Špičák
mesh_terms: D000485:Allergens; D001249:Asthma; D003429:Cross Reactions; D003888:Desensitization, Immunologic; D006801:Humans; D012882:Skin Tests
chemical_list: D000485:Allergens
keywords: cross-reactivity; polyallergy; polysensitization; specific allergen immunotherapy (AIT)