title: OK-432 injection therapy for cystadenocarcinoma of the parotid gland: A case report.
abstract: OK-432 is an immunomodulator that has been reported to be efficacious as an injection therapy for cervical lymphomas and ranulas. We performed OK-432 injection therapy to treat a cystadenocarcinoma of the parotid gland in a 72-year-old man. The 50 × 46-mm tumor was located in the deep lobe of the gland. The tumor had compressed the glossopharyngeal, vagus, and hypoglossal nerves, causing neurally mediated syncope, hoarseness, dysphagia, and dysarthria. A concentration of 5 KE/2 ml of OK-432 was injected. Within 2 months, the cyst had disappeared; no recurrence was apparent during 59 months of follow-up. To the best of our knowledge, no previous report has described injection of OK-432 for malignant cystic disease. We describe the injection method, injection dose, and postinjection course in the hope that this information will prove useful for future applications against malignant cystic disease.
authors.affiliation: Department of Otorhinolaryngology, Nihon University Hospital, 1-6 Kandasurugadai, Chiyoda, Tokyo 101-8309, Japan. mak@med.email.ne.jp.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Makiyama
authors.forename: Ryoji
authors.initials: R
authors.lastname: Hirai
authors.forename: Fusako
authors.initials: F
authors.lastname: Iikuni
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ikeda
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tomomatsu
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003536:Cystadenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010307:Parotid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010844:Picibanil / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D010844:Picibanil