title: Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders.
abstract: Treatments for repetitive behaviors in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders remain an unmet medical need. Mouse models are highly valuable tools for investigating the underlying pathophysiology, genetics, and neurocircuitry of ASD, and can also be characterized for ASD-related phenotypes including repetitive behaviors and stereotypies. This chapter describes methods that can be employed for the assessment of repetitive behavior phenotypes and the evaluation of the ability of test compounds to attenuate repetitive behaviors in mouse models of ASD.
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA. stacey.rizzo@jax.org.
authors.forename: Stacey J Sukoff
authors.initials: SJ
authors.lastname: Rizzo
mesh_terms: D000818:Animals; D000067877:Autism Spectrum Disorder / Q000523:psychology*; D001522:Behavior, Animal; D004195:Disease Models, Animal; D006120:Grooming; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains
keywords: Autism; Behavioral testing; Repetitive behaviors; Repetitive digging; Repetitive grooming; Repetitive jumping; Stereotypy