title: SIV Infection Impairs the Central Nervous System in Chinese Rhesus Macaques.
abstract: The central nervous system (CNS) impairment is a consequence seen in SIV infection of rhesus macaques of Indian-origin, which is more common in infected macaques with rapid disease progression than in those with conventional disease progression. Here, we investigated the CNS damages in SIVmac239-infected Chinese rhesus macaques. We demonstrated that SIV infection of Chinese macaques could cause neuropathological impairments, which was evidenced by appearance of SIV-RNA positive cells, the infiltration of activated macrophages and abundant multinucleated giant cells (MNGCs) in the different regions of the brains. The animals with high viremia and short survival time (average of 16 weeks, rapid progression, RP) had severer neuropathological changes than those with conventional progression (CP). As compared with the RP animals, CP macaques had lower viremia and much longer survival time (average of 154 weeks). These findings indicate that SIVmac239 infection of Chinese rhesus macaque can be used as a suitable animal model and alternative resource for nueroAIDS research.
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Hang
authors.initials: H
authors.lastname: Liu
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Qian-Hao
authors.initials: QH
authors.lastname: Xiao
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Liu
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.|Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
authors.forename: Jie-Liang
authors.initials: JL
authors.lastname: Li
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Qiao-Yang
authors.initials: QY
authors.lastname: Xian
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China.|Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
authors.forename: Wen-Zhe
authors.initials: WZ
authors.lastname: Ho
authors.affiliation: ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences; State Key Laboratory of Virology, Wuhan University, Wuhan, People's Republic of China. zhuangk@whu.edu.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhuang
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology* / Q000821:virology*; D002490:Central Nervous System / Q000473:pathology / Q000821:virology; D002681:China; D005260:Female; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000473:pathology*; D015302:Simian Immunodeficiency Virus
keywords: Chinese rhesus macaque; NeuroAIDS; Neuropathological lesion; Rapid progression; SIVmac239