title: [Application of reporter strains for new antibiotic screening].
abstract: Screening for new antibiotics remains an important area of biology and medical science. Indispensable for this type of research is early identification of antibiotic mechanism of action. Preferentially, it should be studied quickly and cost-effectively, on the stage of primary screening. In this review we describe an application of reporter strains for rapid classification of antibiotics by its target, without prior purification of an active compound and determination of chemical structure.
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Sergiev
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Osterman
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: A Ya
authors.initials: AY
authors.lastname: Golovina
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: I G
authors.initials: IG
authors.lastname: Laptev
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: P I
authors.initials: PI
authors.lastname: Pletnev
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Evfratov
authors.affiliation: Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow region, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Marusich
authors.affiliation: Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow region, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Leonov
authors.affiliation: Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow region, Russia.
authors.forename: Ya A
authors.initials: YA
authors.lastname: Ivanenkov
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Bogdanov
authors.affiliation: Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Dontsova
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D017930:Genes, Reporter; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotic; bacteria; protein synthesis; reporter strain; screening