title: Effects of novel maleimide derivatives on cell cultures with different properties.
abstract: The paper is focused on pilot study of effects of novel synthetic protein kinase inhibitors-maleimide derivatives in different concentrations on normal, transformed and multipotent cell lines. Influence on cell proliferation and morphological characteristics has been demonstrated. The chosen agents cause antiproliferative effect on transformed cells and are not cytotoxic to normal cell lines. Moreover, different maleimide derivatives' effects on multipotent cells in attached and floating states has been shown. Described results can be used for further research of the maleimide derivatives as antitumor agents.
authors.affiliation: Taras Shevchenko National University of Kyiv, Kiev, Ukraine.
authors.forename: Galyna
authors.initials: G
authors.lastname: Ostrovska
authors.affiliation: Taras Shevchenko National University of Kyiv, Kiev, Ukraine.|Hemafund Ltd., Kiev, Ukraine.
authors.forename: Olga
authors.initials: O
authors.lastname: Maslova
authors.affiliation: Department Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Plovdiv, Bulgaria.
authors.forename: Delian
authors.initials: D
authors.lastname: Delev
authors.affiliation: Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
authors.forename: Radka
authors.initials: R
authors.lastname: Opatrilova
authors.affiliation: Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr 1946/1, 612 42, Brno, Czech Republic. kruzliakpeter@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Kuzliak
authors.affiliation: Taras Shevchenko National University of Kyiv, Kiev, Ukraine.
authors.forename: Nataliia
authors.initials: N
authors.lastname: Savytska
mesh_terms: D002461:Cell Line, Transformed; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002477:Cells / Q000166:cytology* / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D008301:Maleimides / Q000737:chemistry / Q000494:pharmacology*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D039902:Multipotent Stem Cells / Q000166:cytology / Q000187:drug effects; D014470:Umbilical Cord / Q000166:cytology
chemical_list: D008301:Maleimides; C043592:maleimide
keywords: Anticancer drug; Antiproliferative effects; Cell cultures; Maleimide derivates