title: Antioxidant activities of curcumin in allergic rhinitis.
abstract: We investigated the antioxidant effects of curcumin in an experimental rat model of allergic rhinitis (AR). Female Wistar albino rats (n = 34) were divided randomly into four groups: healthy rats (control group, n = 8), AR with no treatment (AR + NoTr group, n = 10), AR with azelastine HCl treatment (AR + Aze group, n = 8), and AR with curcumin treatment (AR + Curc group, n = 8). On day 28, total blood IgE levels were measured. For measurement of antioxidant activity, the glutathione (GSH) level and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities were measured in both inferior turbinate tissue and serum. Malondialdehyde (MDA) levels were measured only in inferior turbinate tissue, and paraoxonase (PON) and arylesterase (ARE) activities were measured only in serum. Statistically significant differences were found for all antioxidant measurements (GSH levels and CAT, SOD, GSH-Px activities in the serum and tissue, MDA levels in the tissue, and PON and ARE activities in the serum) between the four groups. In the curcumin group, serum SOD, ARE, and PON and tissue GSH values were higher than the control group. Moreover, tissue GSH levels and serum GSH-Px activities in the curcumin group were higher than in the AR + NoTr group. In the azelastine group, except MDA, antioxidant measurement values were lower than in the other groups. Curcumin may help to increase antioxidant enzymes and decrease oxidative stress in allergic rhinitis. We recommend curcumin to decrease oxidative stress in allergic rhinitis.
authors.affiliation: ENT Clinics, Tuzla State Hospital, Istanbul, Turkey.
authors.forename: Niyazi
authors.initials: N
authors.lastname: Altıntoprak
authors.affiliation: ENT Clinics, Kumluca State Hospital, Antalya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kar
authors.affiliation: ENT Clinics, Yunus Emre State Hospital, Eskisehir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Acar
authors.affiliation: Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Yüzüncü Yıl University, Van, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Berkoz
authors.affiliation: Department of Otorhinolaryngology, Medical Faculty, Kirikkale University, Kirikkale, Turkey. nbayarmuluk@yahoo.com.
authors.forename: Nuray Bayar
authors.initials: NB
authors.lastname: Muluk
authors.affiliation: Department of Otorhinolaryngology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Cingi
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010793:Phthalazines / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D065631:Rhinitis, Allergic / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D000975:Antioxidants; D015415:Biomarkers; D010793:Phthalazines; D003474:Curcumin; C020976:azelastine
keywords: Allergic rhinitis; Antioxidant; Curcumin; Rats