title: MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases.
abstract: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.
  
  
  
  The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.
  
  
  
  There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.
  
  
  
  Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.
authors.affiliation: Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
authors.forename: Haowei
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
authors.forename: Zanjing
authors.initials: Z
authors.lastname: Zhai
authors.affiliation: Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Qu
authors.affiliation: School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, WA 6009, Australia.
authors.forename: Jiake
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
authors.forename: An
authors.initials: A
authors.lastname: Qin
authors.affiliation: Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
authors.forename: Kerong
authors.initials: K
authors.lastname: Dai
mesh_terms: D001847:Bone Diseases / Q000235:genetics* / Q000628:therapy; D001862:Bone Resorption / Q000235:genetics / Q000628:therapy; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D010010:Osteoclasts / Q000166:cytology*; D010012:Osteogenesis
chemical_list: D035683:MicroRNAs
keywords: Drug targets; biogenesis; bone homeostasis; miRNAs; osteoclasts; osteolytic diseases