title: Chemical constituents from the fruiting bodies of Cryptoporus volvatus.
abstract: New drimane-type sesquiterpene cryptoporol A (1), cryptoporic acid derivative 6'-cryptoporic acid E methyl ester (2), and pseudouridine derivative cryptoporine A (3), as well as a known ergosterol 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (4), were isolated from a 90 % alcohol extract of the fruiting bodies of Cryptoporus volvatus. The structures of these compounds were established by spectroscopic analysis and circular dichroism. 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (4) exhibited antiviral activity against porcine reproductive and respiratory syndrome virus, and all compounds showed weak antioxidant activities.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People's Republic of China.
authors.forename: Junchi
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People's Republic of China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Li
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Lv
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People's Republic of China.
authors.forename: Liangang
authors.initials: L
authors.lastname: Shen
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People's Republic of China. jianyongsi1963@126.com.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Si
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D002460:Cell Line; D002522:Chlorocebus aethiops; D055453:Coriolaceae / Q000737:chemistry*; D055808:Drug Discovery / Q000379:methods*; D005609:Free Radicals / Q000737:chemistry; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D019316:Porcine respiratory and reproductive syndrome virus / Q000187:drug effects; D011560:Pseudouridine / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D005609:Free Radicals; D010851:Picrates; D012717:Sesquiterpenes; D011560:Pseudouridine; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Antiviral activity; Cryptoporic acid derivative; Cryptoporus volvatus; Pseudouridine derivative; Sesquiterpene