title: Comparison of the Effects of Myrtus Communis L, Berberis Vulgaris and Metronidazole Vaginal Gel alone for the Treatment of Bacterial Vaginosis.
abstract: BACKGROUND
  There is a growing tendency towards herbal medicines for treatment of vaginitis. Antibacterial and antifungal effects of Myrtus communis L and Berberis vulgaris have been demonstrated invitro and invivo.
  
  
  OBJECTIVE
  This study aimed to compare the therapeutic effects of the vaginal gel of Berberis vulgaris 5% (in metronidazole base) and Myrtus communis L 2% (in metronidazole base) with only metronidazole vaginal gel 0.75% on bacterial vaginosis.
  
  
  METHODS
  This study was a randomized clinical trial research on 120 married women aged 18-40 years affected by bacterial vaginosis attended for treatment to gynaecology clinic of Hajar Hospital (Shahrekord, Iran). They were randomly divided into three groups of 40 participants. Diagnostic criteria were Amsel's criteria. Myrtus communis L, Berberis vulgaris vaginal gel or metronidazole vaginal gel for five-night usage were prescribed to each group, and after 7 days therapeutic effects were assessed. Data analysis was performed using ANOVA and Chi-square tests.
  
  
  RESULTS
  A statistically significant difference was observed with regard to treatment response among the study groups (p<0.001), with Myrtus communis L and Berberis vulgaris groups having a better response than metronidazole gel alone. Moreover, there was no significant difference between Myrtus communis L and Berberis vulgaris groups (p= 0.18). The patients in groups of Myrtus communis L or Berberis vulgaris in metronidazole base did not experience any relapse, but in metronidazole group, 30% of patients experienced relapse during three weeks follow up.
  
  
  CONCLUSIONS
  Findings of the study showed that treatment with a combination of Myrtus communis L or Berberis vulgaris in metronidazole base improve the efficacy of bacterial vaginosis therapy.
authors.affiliation: Resident, Department of Obstetrics and Gynecology, Medical Plants Research Center, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Masoudi
authors.affiliation: Assistant Professor, Department of Obstetrics and Gynecology, Medical Plants Research Center, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Sepideh
authors.initials: S
authors.lastname: Miraj
authors.affiliation: Professor, Cellular and Molecular Research Center, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
keywords: Efficacy; Herbal; Obstetrics; Therapy