title: Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis.
abstract: The adult mammalian brain is a dynamic structure, capable of remodeling in response to various physiological and pathological stimuli. One dramatic example of brain plasticity is the birth and subsequent integration of newborn neurons into the existing circuitry. This process, termed adult neurogenesis, recapitulates neural developmental events in two specialized adult brain regions: the lateral ventricles of the forebrain. Recent studies have begun to delineate how the existing neuronal circuits influence the dynamic process of adult neurogenesis, from activation of quiescent neural stem cells (NSCs) to the integration and survival of newborn neurons. Here, we review recent progress toward understanding the circuit-based regulation of adult neurogenesis in the hippocampus and olfactory bulb.
authors.affiliation: Department of Pharmacology and Pharmacology Training Program, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 Neuroscience Center and Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599.
authors.forename: Juan
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Pharmacology and Pharmacology Training Program, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
authors.forename: Reid H J
authors.initials: RH
authors.lastname: Olsen
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 School of Life Sciences, Tsinghua University, Beijing 100084, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Sun
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685.
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Ming
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*