title: Electrochemical Oxidative Amination of Sodium Sulfinates: Synthesis of Sulfonamides Mediated by NH4I as a Redox Catalyst.
abstract: An efficient protocol for the synthesis of sulfonamides via the electrochemical oxidative amination of sodium sulfinates has been developed. The chemistry proceeds in a simple undivided cell employing a substoichiometric amount of NH4I that serves both as a redox catalyst and a supporting electrolyte; in this manner additional conducting salt is not required. A wide range of substrates, including aliphatic or aromatic secondary and primary amines, as well as aqueous ammonia, proved to be compatible with the protocol. Scale-up was possible, thereby demonstrating the practicality of the approach. The electrolytic process avoids the utilization of external oxidants or corrosive molecular iodine and therefore represents an environmentally benign means by which to achieve the transformation.
authors.affiliation: College of Life Science & Bioengineering, Beijing University of Technology , Beijing 100124, China.
authors.forename: Yang-Ye
authors.initials: YY
authors.lastname: Jiang
authors.affiliation: College of Life Science & Bioengineering, Beijing University of Technology , Beijing 100124, China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Wang
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Food and Chemical Engineering, Beijing Technology and Business University , Beijing 100048, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Liang
authors.affiliation: College of Life Science & Bioengineering, Beijing University of Technology , Beijing 100124, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Hu
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara , Santa Barbara, California 93106-9510, United States.
authors.forename: R Daniel
authors.initials: RD
authors.lastname: Little
authors.affiliation: College of Life Science & Bioengineering, Beijing University of Technology , Beijing 100124, China.|Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Food and Chemical Engineering, Beijing Technology and Business University , Beijing 100048, China.
authors.forename: Cheng-Chu
authors.initials: CC
authors.lastname: Zeng