title: Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice.
abstract: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune inflammatory disease. Typical pathological findings of RA include persistent synovitis and bone degradation in the peripheral joints. Equol, a metabolite of the major soybean isoflavone daidzein, shows superior bioactivity than other isoflavones. We investigated the effects of equol administration on inflammatory response and bone erosion in mice with collagen-induced arthritis (CIA). The severity of arthritis symptoms was significantly low in the equol-administered CIA mice. In addition, equol administration improved the CIA-induced bone mineral density decline. In the inflamed area of CIA mice, equol administration suppressed the expression of interleukin-6 and its receptor. Furthermore, equol reduced the expression of genes associated with bone formation inhibition, osteoclast and immature osteoblast specificity and cartilage destruction. These results suggest that equol suppresses RA development and RA-induced bone erosion by regulating inflammation and bone metabolism.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan.
authors.forename: I-Chian
authors.initials: IC
authors.lastname: Lin
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan.
authors.forename: Shuya
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan.
authors.forename: Motoki
authors.initials: M
authors.lastname: Murata
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan.
authors.forename: Motofumi
authors.initials: M
authors.lastname: Kumazoe
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan. Electronic address: tatibana@agr.kyushu-u.ac.jp.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tachibana
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology; D015551:Autoimmunity; D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology / Q000517:prevention & control*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism; D019587:Dietary Supplements; D015536:Down-Regulation; D060754:Equol / Q000627:therapeutic use*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D005552:Forelimb; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D008297:Male; D008811:Mice, Inbred DBA; D010007:Osteochondritis / Q000209:etiology / Q000517:prevention & control*; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D048789:Phytoestrogens / Q000627:therapeutic use*; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D013047:Specific Pathogen-Free Organisms; D013585:Synovitis / Q000209:etiology / Q000517:prevention & control; D055114:X-Ray Microtomography; D000093242:Interleukin-6 Inhibitors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000894:Anti-Inflammatory Agents, Non-Steroidal; D060754:Equol; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D010750:Phosphoproteins; D048789:Phytoestrogens; D019947:Receptors, Interleukin-6; D000093242:Interleukin-6 Inhibitors; C518716:Mepe protein, mouse; C486030:Sost protein, mouse; C577686:interleukin-6, mouse
keywords: Bone erosion; Cartilage degradation; Equol; Inflammation; Rheumatoid arthritis