title: Prognostic significance of VEGF-C immunohistochemical expression in colorectal cancer: A meta-analysis.
abstract: BACKGROUND
  We sought to comprehensively summarize available evidence for the use of VEGF-C protein to evaluate the clinicopathological and prognostic role of VEGF-C in colorectal cancer.
  
  
  METHODS
  Electronic databases from inception to February 2016 were used to search without language restrictions for original articles. A meta-analysis was undertaken to assess the relationship between VEGF-C expression and overall survival (OS) in colorectal cancer.
  
  
  RESULTS
  Twenty-seven studies were included in the final meta-analysis. We aggregated 13 trials (n=1.428 patients) that evaluated the correlation between OS and VEGF-C overexpression. Statistics were performed for OS (HR=1.95; 95%CI=1.31-2.92, P=0.007). When the studies were stratified by the pathological variables, including T stage (n=383 patients; OR=1.79; 95%CI=1.14-2.81), lymph node metastasis (n=3212 patients; OR=4.21; 95%CI=3.49-5.08), M stage (n=1106 patients; OR=4.46; 95%CI=2.96-6.70), vascular invasion(n=1471 patients; OR=2.18; 95%CI=1.65-2.88), lymph invasion (n=831 patients; OR=3.95; 95%CI=2.80-5.56), histo-differentiation (n=1695 patients; OR=1.34; 95%CI=1.00-1.79) and Duke's stage(n=778 patients; OR=4.90; 95%CI=3.55-6.75), TNM stage (n=808 patients; OR=1.73; 95%CI=1.18-2.54) provided critical and comprehensive prognostic information.
  
  
  CONCLUSIONS
  Our results demonstrated that VEGF-C overexpression was associated with OS in colorectal cancer.
authors.affiliation: Oncology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai TCM University, Shanghai 200071, China. Electronic address: vigilucky@126.com.
authors.forename: Shaoqi
authors.initials: S
authors.lastname: Zong
authors.affiliation: Oncology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai TCM University, Shanghai 200071, China.
authors.forename: Hongjia
authors.initials: H
authors.lastname: Li
authors.affiliation: Oncology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai TCM University, Shanghai 200071, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Oncology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai TCM University, Shanghai 200071, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Oncology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai TCM University, Shanghai 200071, China. Electronic address: 13917367207@163.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Oncology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai TCM University, Shanghai 200071, China. Electronic address: fghou555@hotmail.com.
authors.forename: Fenggang
authors.initials: F
authors.lastname: Hou
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D015996:Survival Rate; D042582:Vascular Endothelial Growth Factor C / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D042582:Vascular Endothelial Growth Factor C
keywords: Colorectal cancer; Meta-analysis; Prognostic; Vascular endothelial growth factor-C