title: Go and NoGo: modulation of electrophysiological correlates by female sex steroid hormones.
abstract: The behavioral and electrophysiological responses in a Go/NoGo task are objective measures of executive functioning that may be impaired in clinical conditions. Prior to the wider application of Go/NoGo tasks in clinics, it is tempting to evaluate factors causing modulation of the responses.
  
  
  
  We aimed to evaluate the effect of different levels of female sex steroids on Go/NoGo task-related ERPs in healthy females.
  
  
  
  Thirty-four young healthy females performed an equiprobable (50/50) auditory Go/NoGo task. Amplitudes and latencies of N2 and P3 peaks from Fz, Cz, and Pz electrodes were evaluated. 17β-estradiol and progesterone levels in saliva samples were measured. Electrophysiological measures were correlated to 17β-estradiol and progesterone concentrations.
  
  
  
  The diverse pattern of modulation of P3 latencies was shown: higher levels of 17β-estradiol contributed to Go-P3 latency prolongation, and higher levels of progesterone contributed to NoGo-P3 latency shortening. Higher levels of 17β-estradiol were associated with more negative frontal N2 amplitude in both conditions.
  
  
  
  The relationship between electrophysiological correlates of executive functioning to individual hormonal levels points to a broader range of variation sources in healthy subjects which might mask or pronounce between-group differences in clinical studies.
authors.affiliation: Department of Neurobiology and Biophysics, Faculty of Natural Sciences, Vilnius University, Sauletekio 7, LT-10222, Vilnius, Lithuania. i.griskova@gmail.com.
authors.forename: Inga
authors.initials: I
authors.lastname: Griskova-Bulanova
authors.affiliation: Department of Neurobiology and Biophysics, Faculty of Natural Sciences, Vilnius University, Sauletekio 7, LT-10222, Vilnius, Lithuania.
authors.forename: Ramune
authors.initials: R
authors.lastname: Griksiene
authors.affiliation: Department of Neurobiology and Biophysics, Faculty of Natural Sciences, Vilnius University, Sauletekio 7, LT-10222, Vilnius, Lithuania.
authors.forename: Aleksandras
authors.initials: A
authors.lastname: Voicikas
authors.affiliation: Department of Neurobiology and Biophysics, Faculty of Natural Sciences, Vilnius University, Sauletekio 7, LT-10222, Vilnius, Lithuania.
authors.forename: Osvaldas
authors.initials: O
authors.lastname: Ruksenas
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D001307:Auditory Perception / Q000502:physiology*; D004569:Electroencephalography; D004958:Estradiol / Q000032:analysis / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D011374:Progesterone / Q000032:analysis / Q000494:pharmacology*; D011930:Reaction Time / Q000502:physiology; D012463:Saliva / Q000737:chemistry; D055815:Young Adult
chemical_list: D011374:Progesterone; D004958:Estradiol
keywords: 17β-estradiol; Auditory Go/NoGo; P3 latency; Progesterone