title: The evaluation of cochlear functions in Familial Mediterranean Fever.
abstract: Familial Mediterranean Fever (FMF) is a progressive disease characterized by chronic inflammation, which also has negative effects on cochlear functions and hearing levels. We investigated whether the cochlear functions and hearing levels of FMF patients were different than healthy controls and also evaluated the relationship of hearing levels with the age at diagnosis, duration without treatment, and inflammation and lipid parameters in this study. A total of 60 patients diagnosed with FMF and 48 age, gender and body mass index (BMI)-matched healthy controls were included in the study. The hemogram, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and lipid parameters of the subjects were studied and they all underwent pure tone audiometry and Transient evoked otoacoustic emission tests after an otologic examination. The hearing levels of the FMF group were significantly higher than those of the control group. The TEOAE signal/noise (S/N) ratios were similar in both groups. A positive relationship was present between the audiometric test results and the age, BMI, low-density lipoprotein and triglyceride levels and a negative relationship with the high-density lipoprotein levels. A negative relationship was present between the TEOAE S/N ratios and the age of the patients, duration without treatment, lipid parameters, inflammation markers and the creatinine level. FMF patients are exposed to chronic inflammation and this can influence their hearing levels. The age at diagnosis, duration without treatment, chronic inflammation, unfavorable lipid parameters, and obesity can affect hearing tests negatively.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Eryilmaz
authors.affiliation: Department of Otorhinolaryngology, Horasan State Hospital, Erzurum, Turkey. abitteryucel@hotmail.com.
authors.forename: Abitter
authors.initials: A
authors.lastname: Yucel
authors.affiliation: Department of Internal Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Cure
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Diskapi Training and Research Hospital, Ankara, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Sakiz
authors.affiliation: Department of Otorhinolaryngology, Duzce State Hospital, Duzce, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Koder
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Malatya State Hospital, Konya, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Kucuk
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Tunc
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001301:Audiometry, Pure-Tone; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D005072:Evoked Potentials, Auditory / Q000502:physiology; D010505:Familial Mediterranean Fever / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002097:C-Reactive Protein
keywords: Cochlear involvement; Familial Mediterranean Fever; Pure tone audiometry; Transient evoked otoacoustic emission test