title: MeCorS: Metagenome-enabled error correction of single cell sequencing reads.
abstract: We present a new tool, MeCorS, to correct chimeric reads and sequencing errors in Illumina data generated from single amplified genomes (SAGs). It uses sequence information derived from accompanying metagenome sequencing to accurately correct errors in SAG reads, even from ultra-low coverage regions. In evaluations on real data, we show that MeCorS outperforms BayesHammer, the most widely used state-of-the-art approach. MeCorS performs particularly well in correcting chimeric reads, which greatly improves both accuracy and contiguity of de novo SAG assemblies.
  
  
  
  https://github.com/metagenomics/MeCorS CONTACT: abremges@cebitec.uni-bielefeld.de
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Center for Biotechnology and Faculty of Technology, Bielefeld University, Bielefeld 33615, Germany U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bremges
authors.affiliation: U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA.
authors.forename: Esther
authors.initials: E
authors.lastname: Singer
authors.affiliation: U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA.
authors.forename: Tanja
authors.initials: T
authors.lastname: Woyke
authors.affiliation: Center for Biotechnology and Faculty of Technology, Bielefeld University, Bielefeld 33615, Germany U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Sczyrba
mesh_terms: D000465:Algorithms; D004926:Escherichia coli / Q000235:genetics; D054892:Metagenome; D017422:Sequence Analysis, DNA / Q000379:methods*; D059010:Single-Cell Analysis; D012984:Software