title: [Prospects of Pharmacogenetic Testing for Design of Algorithms for Personalized Treatment of Tuberculosis of Respiratory Organs in the Astrakhan Region].
abstract: In spite of the availability of many antituberculosis drugs all over the world the morbidity of tuberculosis does not lower. Often the tuberculosis therapy schemes are adapted to every particular patient which is mainly due to the therapy unfavourable effects requiring discontinuation of the drugs used. Polymorphism of the detoxication genes, as predictors of the response to the drug therapy, was shown to be of certain significance. The experimental data would allow to substantiate personalized management of tuberculosis patients and to increase its efficacy and safety.
authors.forename: B I
authors.initials: BI
authors.lastname: Kantemirova
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Galimzyanov
authors.forename: N A
authors.initials: NA
authors.lastname: Stepanova
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Chernysheva
authors.forename: Z A
authors.initials: ZA
authors.lastname: Alieva
mesh_terms: D000328:Adult; D000465:Algorithms; D000995:Antitubercular Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D065729:Cytochrome P-450 CYP2C9 / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D011110:Polymorphism, Genetic; D057285:Precision Medicine / Q000379:methods*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000235:genetics; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D019392:Cytochrome P-450 CYP2E1; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human