title: Comparison of the traditional pharmaceutical validation method versus an assisted pharmaceutical validation in hospitalized patients.
abstract: To analyze pharmaceutical interventions that have been carried out with the support of an automated system for validation of treatments vs. the traditional method without computer support.
  
  
  
  The automated program, ALTOMEDICAMENTOS® version 0, has 925 052 data with information regarding approximately 20 000 medicines, analyzing doses, administration routes, number of days with such a treatment, dosing in renal and liver failure, interactions control, similar drugs, and enteral medicines. During eight days, in four different hospitals (high complexity with over 1 000 beds, 400-bed intermediate, geriatric and monographic), the same patients and treatments were analyzed using both systems.
  
  
  
  3,490 patients were analyzed, with 42 155 different treatments. 238 interventions were performed using the traditional system (interventions 0.56% / possible interventions) vs. 580 (1.38%) with the automated one. Very significant pharmaceutical interventions were 0.14% vs. 0.46%; significant was 0.38% vs. 0.90%; non-significant was 0.05% vs. 0.01%, respectively. If both systems are simultaneously used, interventions are performed in 1.85% vs. 0.56% with just the traditional system. Using only the traditional model, 30.5% of the possible interventions are detected, whereas without manual review and only the automated one, 84% of the possible interventions are detected.
  
  
  
  The automated system increases pharmaceutical interventions between 2.43 to 3.64 times. According to the results of this study the traditional validation system needs to be revised relying on automated systems. The automated program works correctly in different hospitals.
authors.affiliation: Hospital Nacional de Parapléjicos, Toledo.. davidgarciamarco@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: García Marco
authors.affiliation: Hospital Universitario Fundación Alcorcón.. davidgarciamarco@gmail.com.
authors.forename: M V
authors.initials: MV
authors.lastname: Hernández Sánchez
authors.affiliation: Hospital Universitario Fundación Alcorcón.. davidgarciamarco@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Sanz Márquez
authors.affiliation: Hospital Universitario Fundación Alcorcón.. davidgarciamarco@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Pérez Encinas
authors.affiliation: Hospital Nacional de Parapléjicos, Toledo.. davidgarciamarco@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Shaw Toda
authors.affiliation: Hospital Universitario 12 de Octubre, Madrid.. davidgarciamarco@gmail.com.
authors.forename: M J
authors.initials: MJ
authors.lastname: Jiménez Cerezo
authors.affiliation: Hospital Universitario 12 de Octubre, Madrid.. davidgarciamarco@gmail.com.
authors.forename: J M
authors.initials: JM
authors.lastname: Ferrari Piquero
authors.affiliation: Hospital Virgen Valle, Toledo. Spain.. davidgarciamarco@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Martínez Camacho
mesh_terms: D000328:Adult; D001331:Automation; D002648:Child; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004358:Drug Therapy / Q000379:methods* / Q000592:standards*; D006801:Humans; D007297:Inpatients; D017093:Liver Failure / Q000139:chemically induced / Q000175:diagnosis; D016347:Medical Records Systems, Computerized; D008510:Medication Systems, Hospital; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000139:chemically induced / Q000175:diagnosis