title: Fibersol-2 induces apoptosis of Apc-deficient colorectal Cancer (SW480) cells and decreases polyp formation in Apc MIN mice.
abstract: The consumption of dietary fibers has been implicated with a lowered risk of human colorectal cancer. Proposed mechanisms involve alterations in the stool consistency, transit time, and formation of short-chain fatty acid by dietary fiber fermentation, and the reorganization of gut microbiota. Here we show that Fibersol-2, a digest-resistant maltodextrin, not only inhibits proliferation of colorectal SW480 cancer cell lines by increasing reactive oxygen species (ROS), but decreases the numbers of the adenoma count in Multiple Intestinal Neoplasia (MIN) mice carrying a mutation in the Adenomatous Polyposis Coli gene by 84 d of age. These observations provide direct evidence that Fibersol-2 intrinsically contains anti-cancer activity, independent of the intestinal metabolism and any potential interactions with the microbiota.
authors.affiliation: a Department of Cancer Genetics , Roswell Park Cancer Institute , Buffalo , NY , USA.
authors.forename: Sara Cuesta
authors.initials: SC
authors.lastname: Sancho
authors.affiliation: b Deparment of Biological Sciences , University of Wisconsin Parkside , Kenosha , WI , USA.
authors.forename: Susan Losee
authors.initials: SL
authors.lastname: Olson
authors.affiliation: a Department of Cancer Genetics , Roswell Park Cancer Institute , Buffalo , NY , USA.
authors.forename: Eui
authors.initials: E
authors.lastname: Young So
authors.affiliation: c Matsutani America Inc. , Itasca , IL , USA.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimomura
authors.affiliation: a Department of Cancer Genetics , Roswell Park Cancer Institute , Buffalo , NY , USA.
authors.forename: Toru
authors.initials: T
authors.lastname: Ouchi
authors.affiliation: b Deparment of Biological Sciences , University of Wisconsin Parkside , Kenosha , WI , USA.
authors.forename: Fabian
authors.initials: F
authors.lastname: Preuss
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000473:pathology / Q000517:prevention & control*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011127:Polyps / Q000378:metabolism*; D017382:Reactive Oxygen Species
chemical_list: D004043:Dietary Fiber; D017382:Reactive Oxygen Species
keywords: Apc; MIN; apoptosis; cancer; fibersol; maltodextrin