title: Combenefit: an interactive platform for the analysis and visualization of drug combinations.
abstract: Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies.
  
  
  
  We present Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and/or antagonism. Data from combinations assays can be processed using classical Synergy models (Loewe, Bliss, HSA), as single experiments or in batch for High Throughput Screens. This user-friendly tool provides laboratory scientists with an easy and systematic way to analyze their data. The companion package provides bioinformaticians with critical implementations of routines enabling the processing of combination data.
  
  
  
  Combenefit is provided as a Matlab package but also as standalone software for Windows (http://sourceforge.net/projects/combenefit/).
  
  
  
  Giovanni.DiVeroli@cruk.cam.ac.uk
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: CRUK Cambridge Institute, University of Cambridge, Cambridge, UK Early Clinical Development, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK.
authors.forename: Giovanni Y
authors.initials: GY
authors.lastname: Di Veroli
authors.affiliation: CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.
authors.forename: Chiara
authors.initials: C
authors.lastname: Fornari
authors.affiliation: Bioinformatics, Oncology Innovative Medicines, AstraZeneca, Cambridge, UK.
authors.forename: Dennis
authors.initials: D
authors.lastname: Wang
authors.affiliation: CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.
authors.forename: Séverine
authors.initials: S
authors.lastname: Mollard
authors.affiliation: CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.
authors.forename: Jo L
authors.initials: JL
authors.lastname: Bramhall
authors.affiliation: CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.
authors.forename: Frances M
authors.initials: FM
authors.lastname: Richards
authors.affiliation: CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.
authors.forename: Duncan I
authors.initials: DI
authors.lastname: Jodrell
mesh_terms: D019295:Computational Biology / Q000379:methods; D004338:Drug Combinations; D016503:Drug Delivery Systems; D059014:High-Throughput Nucleotide Sequencing; D012984:Software; D014584:User-Computer Interface
chemical_list: D004338:Drug Combinations