title: [Change of Tumor Cell Multiple Drug Resistance Inhibitory Activity of Oligomycins in Complexes with Lithium and Zinc].
abstract: Oligomycins and their complexes with lithium and zinc were shown to be less active vs. cyclosporin A in inhibition of transport proteins responsible for multiple drug resistance of lymphoid leukosis P388VR cells, while certain oligomycin complexes were tens or hundreds times more active than cyclosporin A by inhibition of transport proteins in another type of tumor cells, i.e. human larynx cancer Hep-2, that makes possible the use of the oligomycins complexes with lithium and zinc for inhibition of multiple drug resistance of certain tumor types.
authors.forename: M V
authors.initials: MV
authors.lastname: Bibikova
authors.forename: A N
authors.initials: AN
authors.lastname: Danilenko
authors.forename: A V
authors.initials: AV
authors.lastname: Katlinsky
authors.forename: A F
authors.initials: AF
authors.lastname: Korystova
authors.forename: L N
authors.initials: LN
authors.lastname: Kublik
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Levitman
authors.forename: V V
authors.initials: VV
authors.lastname: Shaposhnikova
authors.forename: Yu N
authors.initials: YN
authors.lastname: Korystov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D008094:Lithium / Q000737:chemistry*; D051379:Mice; D008811:Mice, Inbred DBA; D009840:Oligomycins / Q000737:chemistry / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002352:Carrier Proteins; D056831:Coordination Complexes; D009840:Oligomycins; D008094:Lithium; D015032:Zinc