title: Pathology interface for the molecular analysis of tissue by mass spectrometry.
abstract: BACKGROUND
  Imaging mass spectrometry (IMS) generates molecular images directly from tissue sections to provide better diagnostic insights and expand the capabilities of clinical anatomic pathology. Although IMS technology has matured over recent years, the link between microscopy imaging currently used by pathologists and MS-based molecular imaging has not been established.
  
  
  METHODS
  We adapted the Vanderbilt University Tissue Core workflow for IMS into a web-based system that facilitates remote collaboration. The platform was designed to perform within acceptable web response times for viewing, annotating, and processing high resolution microscopy images.
  
  
  RESULTS
  We describe a microscopy-driven approach to tissue analysis by IMS.
  
  
  CONCLUSIONS
  The Pathology Interface for Mass Spectrometry is designed to provide clinical access to IMS technology and deliver enhanced diagnostic value.
authors.affiliation: Department of Biochemistry, National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37240, USA.
authors.forename: Jeremy L
authors.initials: JL
authors.lastname: Norris
authors.affiliation: Department of Biochemistry, National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37240, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Tsui
authors.affiliation: Department of Biochemistry, National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37240, USA.
authors.forename: Danielle B
authors.initials: DB
authors.lastname: Gutierrez
authors.affiliation: Department of Biochemistry, National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37240, USA.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Caprioli
keywords: Diagnostics; imaging mass spectrometry; molecular imaging