title: Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro.
abstract: Curcumin is more soluble in ethanol, dimethylsulfoxide, methanol and acetone than in water. In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four bacteria strains (two Gram positive: Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213 and two Gram negative: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), mammalian cell line (HEK) and human erythrocytes (RBC). The efficiency (E%) between IC50of nanocurcumin combined with magnetic field (NANOCUR-MF) and control against PC3 was 35.93%, which is three times higher compared to curcumin combined with magnetic field (CUR-MF); i.e., 10.77%. However, their E% against HEK was not significant; 1.4% for NANOCUR-MF and 1.95% for CUR-MF. Moreover, depending in minimum bacterial concentration (MBC), the use of MF leads to a reduction of MBCs for all tested bacteria compared with control. The obtained results established the applicability of (MF) in enhancing cellular uptake for PC3 and tested bacteria strains by increasing the penetration of drug (nanocurcumin and parent curcumin) into cell with fixing mild cytotoxic profile for HEK and RBC.
authors.affiliation: a School of Physics, Universiti Sains Malaysia, USM , Penang , Malaysia.
authors.forename: Mo'ath Ahmad
authors.initials: MA
authors.lastname: Aldahoun
authors.affiliation: a School of Physics, Universiti Sains Malaysia, USM , Penang , Malaysia.
authors.forename: M S
authors.initials: MS
authors.lastname: Jaafar
authors.affiliation: b Department of Physics, Bio-Medical Physics Laboratory , Jordan University of Science & Technology (JUST) , Irbid , Jordan.
authors.forename: M-Ali H
authors.initials: MH
authors.lastname: Al-Akhras
authors.affiliation: c Department of Physics , College of Science, University of Bahrain , AlZallaq , Kingdom of Bahrain.
authors.forename: M
authors.initials: M
authors.lastname: Bououdina
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001682:Biological Availability; D001692:Biological Transport; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D060526:Magnetic Fields; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003474:Curcumin
keywords: Anticancer; antimicrobial; drug delivery; magnetic field; membrane-permeation; nanocurcumin