title: Keratoprosthesis in Ectodermal Dysplasia.
abstract: OBJECTIVE
  To describe the complex surgical management and novel medical approach for a keratoprosthesis (KPro Boston type I) in a monocular, 73-year-old patient with ectodermal dysplasia and chronic, noninfectious corneal necrosis.
  
  
  METHODS
  Best-corrected visual acuity (BCVA) was measured with Snellen letters. Surgical intervention included an amniotic membrane graft, complete replacement of the KPro, conjunctival flap graft, corneal donor tissue grafts combined with inferior rectus muscle advancement, periosteal tissue graft, tarso-conjunctival flap construction, and symblepharolysis. Infliximab was used as a medical adjunctive therapy.
  
  
  RESULTS
  Initial KPro placement provided a BCVA of 20/25 and long-term stability. Subsequent chronic melting at the optic border necessitated numerous surgeries to prevent extrusion and failure. Ultimate fistulization was addressed with the formation of a surgical pocket. The addition of infliximab promoted ocular surface stability, and the patient has maintained a BCVA of 20/80.
  
  
  CONCLUSIONS
  Ectodermal dysplasia can result in eyelid and corneal abnormalities, requiring a KPro for visual restoration. In the setting of chronic, sterile corneal melt, novel surgical approaches and the off-label use of infliximab allowed for visual rehabilitation.
authors.affiliation: University of Rochester, Flaum Eye Institute, Rochester, NY.
authors.forename: Rachel A F
authors.initials: RA
authors.lastname: Wozniak
authors.forename: Mithra
authors.initials: M
authors.lastname: Gonzalez
authors.forename: James V
authors.initials: JV
authors.lastname: Aquavella
mesh_terms: D000368:Aged; D001187:Artificial Organs; D001705:Bioprosthesis; D003315:Cornea; D003318:Corneal Opacity / Q000209:etiology / Q000601:surgery*; D004476:Ectodermal Dysplasia / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D019919:Prosthesis Implantation; D012189:Retrospective Studies; D014786:Vision Disorders / Q000503:physiopathology / Q000534:rehabilitation; D014792:Visual Acuity