title: Benign hormone-secreting adenoma within a larger adrenocortical mass showing intensely increased activity on18F-FDG PET/CT.
abstract: Adrenal adenomas usually show18F-FDG activity less than that of the liver parenchyma. However, lipid-poor and hormone-secreting adenomas have been reported to show mild18F-FDG avidity. We report on a 51-year-old female with clinical symptoms of hypercortisolemia and a large right adrenal mass detected on CT. Post-contrast CT images showed an enhancing focus in the lower pole of the mass, with corresponding markedly increased activity on18F-FDG PET/CT. Right adrenalectomy was performed and histology revealed a benign adenoma, indicating that functioning benign adenomas can show intensely increased metabolic activity on18F-FDG mimicking malignancy.
authors.affiliation: Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center (CC), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.affiliation: Division of Nuclear Medicine, RAD&IS; Clinical Center, National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.affiliation: Section on Endocrinology and Genetics, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Building 10, CRC, Room 1-3330, MSC1103, Bethesda, MD, 20892, USA. stratakc@mail.nih.gov.
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Stratakis
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging*; D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/CT; Adenoma(s); Adrenal glands; Computed Tomography (CT)