title: MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer.
abstract: MicroRNAs (miRNAs) regulate gene expression and are involved in cervical cancer. But the molecular mechanism is still unclear. Here, miRNA profile of cervical cancer was performed and demonstrated that miR-486-3p decreased in specimens of cervical cancer patients. In addition, our clinical data show that decreased miR-486-3p was associated with metastasis in cervical cancer patients. ECM1 was predicted and velified as a target gene of miR-486-3p. Overexpression of miR-486-3p inhibited cell growth and metastasis by targeting ECM1. In a conclusion, these findings suggest that miR-486-3p is a tumor suppressor miRNA and induction of miR-486-3p is a potential strategy to inhibit cervical cancer progression.
authors.affiliation: Department of Obstetrics and Gynecology, The Affiliated Hospital of SouthWest Medical University, Sichuan, China.
authors.forename: Haiqiong
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Obstetrics and Gynecology, The Affiliated TCM Hospital of SouthWest Medical University, Sichuan, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Yu
authors.affiliation: The Institute of Cancer Research, SouthWest Medical University, Sichuan, China.
authors.forename: Jiyi
authors.initials: J
authors.lastname: Xia
authors.affiliation: Experimental Medicine Center, The Affiliated Hospital of SouthWest Medical University, Sichuan, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Tang
authors.affiliation: Experimental Medicine Center, The Affiliated Hospital of SouthWest Medical University, Sichuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.affiliation: Experimental Medicine Center, The Affiliated Hospital of SouthWest Medical University, Sichuan, China. Electronic address: river_chen15@sohu.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D001483:Base Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D020411:Oligonucleotide Array Sequence Analysis; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: C490607:ECM1 protein, human; D016326:Extracellular Matrix Proteins; C560945:MIRN486 microRNA, human; D035683:MicroRNAs
keywords: Cervical cancer; ECM1; miR-486-3p