title: Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.
abstract: A large variety of mouse models for human skin, hair, and nail diseases are readily available from investigators and vendors worldwide. Mouse skin is a simple organ to observe lesions and their response to therapy, but identifying and monitoring the progress of treatments of mouse skin diseases can still be challenging. This chapter provides an overview on how to use the laboratory mouse as a preclinical tool to evaluate efficacy of new compounds or test potential new uses for compounds approved for use for treating an unrelated disease. Basic approaches to handling mice, applying compounds, and quantifying effects of the treatment are presented.
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609-1500, USA. john.sundberg@jax.org.
authors.forename: John P
authors.initials: JP
authors.lastname: Sundberg
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609-1500, USA.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Silva
authors.affiliation: Division of Dermatology, Department of Medicine, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Lloyd E
authors.initials: LE
authors.lastname: King
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609-1500, USA.
authors.forename: C Herbert
authors.initials: CH
authors.lastname: Pratt
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D012867:Skin / Q000187:drug effects; D012871:Skin Diseases / Q000188:drug therapy*
keywords: Alopecia areata; Atopic dermatitis; Chronic proliferative dermatitis; Full thickness skin grafts; Hair; Skin; Xenograft