title: Complete genome sequence of an agr-dysfunctional variant of the ST239 lineage of the methicillin-resistant Staphylococcus aureus strain GV69 from Brazil.
abstract: Staphylococcus aureus is a versatile Gram-positive coccus frequently found colonizing the skin and nasal membranes of humans. The acquisition of the staphylococcal cassette chromosome mec was a major milestone in the evolutionary path of methicillin-resistant S. aureus. This genetic element carries the mecA gene, the main determinant of methicillin resistance. MRSA is involved in a plethora of opportunistic infectious diseases. The accessory gene regulator is the major S. aureus quorum sensing system, playing an important role in staphylococcal virulence, including the development of biofilms. We report the complete genome sequence (NCBI BioProject ID: PRJNA264181) of the methicillin-resistant S. aureus strain GV69 (= CMVRS P4521), a variant of the ST239 lineage that presents with a natural attenuation of agr-RNAIII transcription and a moderate accumulation of biofilm.
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
authors.forename: Ana M N
authors.initials: AMN
authors.lastname: Botelho
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
authors.forename: Maiana O C
authors.initials: MOC
authors.lastname: Costa
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
authors.forename: Cristiana O
authors.initials: CO
authors.lastname: Beltrame
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
authors.forename: Fabienne A
authors.initials: FA
authors.lastname: Ferreira
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
authors.forename: Marina F
authors.initials: MF
authors.lastname: Côrtes
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
authors.forename: Paula T
authors.initials: PT
authors.lastname: Bandeira
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
authors.forename: Nicholas C B
authors.initials: NCB
authors.lastname: Lima
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
authors.forename: Rangel C
authors.initials: RC
authors.lastname: Souza
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
authors.forename: Luiz G P
authors.initials: LGP
authors.lastname: Almeida
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
authors.forename: Ana T R
authors.initials: ATR
authors.lastname: Vasconcelos
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
authors.forename: Marisa F
authors.initials: MF
authors.lastname: Nicolás
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
authors.forename: Agnes M S
authors.initials: AMS
authors.lastname: Figueiredo
keywords: Complete genome sequence; Methicillin-resistant Staphylococcus aureus; ST239; Skin hospital infection; agr dysfunction