title: Inflammation-Induced Plasticity in Melanoma Therapy and Metastasis.
abstract: Phenotype switching contributes to nongenomic heterogeneity in melanoma and other cancers. These dynamic and in part reversible phenotype changes impose diagnostic and therapeutic challenges. Understanding the reciprocal coevolution of melanoma and immune cell phenotypes during disease progression and in response to therapy is a prerequisite to improve current treatment strategies. Here we discuss how proinflammatory signals promote melanoma cell plasticity and govern interactions of melanoma and immune cells in the tumor microenvironment. We examine phenotypic plasticity and heterogeneity in different melanoma mouse models with respect to their utility for translational research and emphasize the interplay between melanoma cells and neutrophils as a critical driver of metastasis.
authors.affiliation: Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53105 Bonn, Germany. Electronic address: Michael.Hoelzel@ukb.uni-bonn.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Hölzel
authors.affiliation: Department of Dermatology, University Hospital Magdeburg, 39120 Magdeburg, Germany. Electronic address: Thomas.Tueting@med.ovgu.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Tüting
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism*; D063646:Carcinogenesis; D002450:Cell Communication; D000066670:Cell Plasticity; D004195:Disease Models, Animal; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008545:Melanoma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D051379:Mice; D009362:Neoplasm Metastasis; D009504:Neutrophils / Q000276:immunology*; D059016:Tumor Microenvironment
chemical_list: D000951:Antigens, Neoplasm
keywords: inflammation; melanoma; metastasis; neutrophils; plasticity; resistance