title: Secreted fungal aspartic proteases: A review.
abstract: The aspartic proteases, also called aspartyl and aspartate proteases or acid proteases (E.C.3.4.23), belong to the endopeptidase family and are characterized by the conserved sequence Asp-Gly-Thr at the active site. These enzymes are found in a wide variety of microorganisms in which they perform important functions related to nutrition and pathogenesis. In addition, their high activity and stability at acid pH make them attractive for industrial application in the food industry; specifically, they are used as milk-coagulating agents in cheese production or serve to improve the taste of some foods. This review presents an analysis of the characteristics and properties of secreted microbial aspartic proteases and their potential for commercial application.
authors.affiliation: Universidad Politécnica de Pachuca, Zempoala, Hidalgo, Mexico.
authors.forename: Virginia
authors.initials: V
authors.lastname: Mandujano-González
authors.affiliation: Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Villa-Tanaca
authors.affiliation: Universidad Politécnica de Pachuca, Zempoala, Hidalgo, Mexico.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Anducho-Reyes
authors.affiliation: Universidad Politécnica de Pachuca, Zempoala, Hidalgo, Mexico. Electronic address: yuridiamercado@upp.edu.mx.
authors.forename: Yuridia
authors.initials: Y
authors.lastname: Mercado-Flores
mesh_terms: D020816:Amino Acid Motifs; D057055:Aspartic Acid Proteases / Q000737:chemistry / Q000145:classification / Q000378:metabolism / Q000494:pharmacology; D020134:Catalytic Domain; D004792:Enzyme Precursors / Q000378:metabolism; D005516:Food Microbiology; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005658:Fungi / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic; D015966:Gene Expression Regulation, Fungal; D006863:Hydrogen-Ion Concentration; D007218:Industrial Microbiology; D011480:Protease Inhibitors / Q000494:pharmacology; D013379:Substrate Specificity
chemical_list: D004792:Enzyme Precursors; D005656:Fungal Proteins; D011480:Protease Inhibitors; D057055:Aspartic Acid Proteases
keywords: Aspartil-proteasas secretadas; E.C.3.4.23; Enzimas fúngicas; Fungal enzymes; Secreted aspartic proteases