title: In vitro susceptibility of Scedosporium isolates to N-acetyl-L-cysteine alone and in combination with conventional antifungal agents.
abstract: In recent years, Scedosporium species have been more commonly recognized from severe, difficult-to-treat human infections, such as upper respiratory tract and pulmonary infections. To select an appropriate therapeutic approach for these infections is challenging, because of the commonly observed resistance of the causative agents to several antifungal drugs. Therefore, to find a novel strategy for the treatment of pulmonary Scedosporium infections the in vitro antifungal effect of a mucolytic agent, N-acetyl-L-cysteine and its in vitro combinations with conventional antifungals were investigated. Synergistic and indifferent interactions were registered in 23 and 13 cases, respectively. Antagonism was not revealed between the compounds.
authors.affiliation: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Közép fasor 52, H-6726 Szeged, Hungary.
authors.forename: Mónika
authors.initials: M
authors.lastname: Homa
authors.affiliation: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Közép fasor 52, H-6726 Szeged, Hungary Medical University of Innsbruck, Biocenter, Division of Molecular Biology, Innrain 80-82, A-6020 Innsbruck, Austria galgoczi@gmail.com.
authors.forename: László
authors.initials: L
authors.lastname: Galgóczy
authors.affiliation: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Közép fasor 52, H-6726 Szeged, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Tóth
authors.affiliation: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Közép fasor 52, H-6726 Szeged, Hungary.
authors.forename: Máté
authors.initials: M
authors.lastname: Virágh
authors.affiliation: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Muthusamy
authors.initials: M
authors.lastname: Chandrasekaran
authors.affiliation: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Közép fasor 52, H-6726 Szeged, Hungary Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Csaba
authors.initials: C
authors.lastname: Vágvölgyi
authors.affiliation: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Közép fasor 52, H-6726 Szeged, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Papp
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D021681:Scedosporium / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D000111:Acetylcysteine
keywords: N-acetyl-L-cysteine; Scedosporium spp.; antifungal activity; drug combinations; pulmonary infection; synergistic interaction