title: [Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone].
abstract: Rhabdomyolysis is a rare but well-known complication of statin therapy. The risk is considerably increased when concomitant drugs are administered that inhibit metabolism and breakdown via the cytochrome CYP3A4. We report a case of myoglobin-induced acute renal failure secondary to the concomitant use of simvastatin and amiodarone. The risk of rhabdomyolysis is mainly determined by the statin dose; in the case of the concomitant use of CYP3A4 inhibitors, a maximal daily dose of 20 mg is recommended to avoid harmful drug interactions.
authors.affiliation: Klinik für Anästhesie Intensive und Rettungsmedizin, Kantonsspital St. Gallen, Rorschacherstr., 9007, St. Gallen, Schweiz. urs.pietsch@kssg.ch.
authors.forename: U
authors.initials: U
authors.lastname: Pietsch
authors.affiliation: Klinik für Anästhesie Intensive und Rettungsmedizin, Kantonsspital St. Gallen, Rorschacherstr., 9007, St. Gallen, Schweiz.
authors.forename: C
authors.initials: C
authors.lastname: Müller-Höcker
authors.affiliation: Klinik für Anästhesie Intensive und Rettungsmedizin, Kantonsspital St. Gallen, Rorschacherstr., 9007, St. Gallen, Schweiz.
authors.forename: M
authors.initials: M
authors.lastname: Filipovic
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000652:urine*; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D009212:Myoglobinuria / Q000652:urine*; D017582:Renal Replacement Therapy; D012206:Rhabdomyolysis / Q000139:chemically induced; D012772:Shock, Septic / Q000150:complications / Q000188:drug therapy; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D000638:Amiodarone
keywords: Acute renal failure; Amiodaron; Myoglobinuria; Rhabdomyolyse