title: Regulation of actin nucleation and autophagosome formation.
abstract: Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.
authors.affiliation: Laboratory of Cancer Biology, Medical Sciences Division, Department of Oncology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Off Roosevelt Drive, Oxford, OX3 7DQ, UK.
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Coutts
authors.affiliation: Laboratory of Cancer Biology, Medical Sciences Division, Department of Oncology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Off Roosevelt Drive, Oxford, OX3 7DQ, UK. nick.lathangue@oncology.ox.ac.uk.
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: La Thangue
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D000818:Animals; D000071182:Autophagosomes / Q000378:metabolism*; D001343:Autophagy / Q000502:physiology*; D008247:Lysosomes / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009218:Myosins / Q000378:metabolism
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D008869:Microtubule-Associated Proteins; D009218:Myosins
keywords: Actin; Arp2/3; Autophagosome; Autophagy; JMY; LC3; WH2