title: Differences in clinical characteristics between patients with and without type 2 diabetes hospitalized with a first myocardial infarction.
abstract: To explore differences in clinical characteristics of patients with and without type 2 diabetes (T2DM) hospitalized with a first myocardial infarction (MI).
  
  
  
  In this cross-sectional study we examined differences between patients with and without T2DM hospitalized with a first MI (n=563). Multiple linear regression modeling was used to examine the association between T2DM and age of occurrence of MI. We adjusted for gender, systolic blood pressure (BP), lipids and creatinine level to examine whether these variables explained the association between T2DM and age of occurrence of MI.
  
  
  
  Among 563 patients with a first MI, T2DM patients (n=77) were older than non-diabetic patients (67.8±10.9 vs. 64.4±13.4years, p<0.05), had lower LDL (2.5±0.8 vs. 3.4±1.1mmol/l, p<0.001) and total cholesterol levels (4.4±0.9 vs. 5.4±1.2mmol/l, p<0.001), but higher systolic BP (150.3±29.9 vs. 141.7±27.5mmHg, p<0.05). The association between T2DM and age of occurrence of MI was largely explained by cholesterol levels.
  
  
  
  T2DM patients were older when hospitalized with a first MI. This difference was largely explained by differences in cholesterol levels. The lower cholesterol levels in T2DM patients compared to non-diabetic patients, and maybe also the older age of occurrence of MI, might reflect the results successful primary prevention and systematic monitoring in T2DM.
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands, P.O. Box 8500, 3508 GA Utrecht. Electronic address: M.j.kasteleyn@umcutrecht.nl.
authors.forename: Marise J
authors.initials: MJ
authors.lastname: Kasteleyn
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands, P.O. Box 8500, 3508 GA Utrecht. Electronic address: r.c.vos-3@umcutrecht.nl.
authors.forename: Rimke C
authors.initials: RC
authors.lastname: Vos
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands, P.O. Box 8500, 3508 GA Utrecht. Electronic address: hannekejansen@gmail.com.
authors.forename: Hanneke
authors.initials: H
authors.lastname: Jansen
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands, P.O. Box 8500, 3508 GA Utrecht. Electronic address: g.e.h.m.rutten@umcutrecht.nl.
authors.forename: Guy E H M
authors.initials: GE
authors.lastname: Rutten
mesh_terms: D000046:Academic Medical Centers; D017668:Age of Onset; D000368:Aged; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003131:Combined Modality Therapy; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D058065:Diabetic Cardiomyopathies / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D009426:Netherlands / Q000453:epidemiology; D010349:Patient Compliance; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D008078:Cholesterol, LDL; D002784:Cholesterol
keywords: Cholesterol; Clinical characteristics; Myocardial infarction; Prevention; Type 2 diabetes