title: Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies.
abstract: BACKGROUND
  Low histamine metabolism has been suggested to play a role in the pathogenesis of allergy and migraine. We investigated the possible association between 2 single-nucleotide polymorphisms (SNP), C314T HNMT and C2029G DAO, and the presence and severity of migraine and migraine-related disability.
  
  
  METHODS
  We studied the frequency of C314T HNMT and C2029G DAO allelic variants in 162 mothers of children with allergies (80 with migraine and 82 without) using a TaqMan-based qPCR Assay and a case-control model. We conducted a logistic regression analysis to examine the association between migraine and the allelic and haplotype variants.
  
  
  RESULTS
  Mutant C2029G DAO SNP was found significantly more frequently in the group of women with migraine than in controls (OR, 1.6; 95% CI, 1.1-2.1). No significant differences were found in frequencies of genotypes or alleles in the case of C314T HNMT SNP. Both mutated alleles were associated with migraine-related disability. Coexistence of alleles for both SNPs (haplotypes) showed a strong association with migraine. Haplotypes containing both mutated alleles (either heterozygous or homozygous) were very strongly associated with MIDAS grade iv migraine (OR, 45.0; 95% CI, 5.2-358). This suggests that mutant alleles of C314T for HNMT and C2029G for DAO polymorphisms may interact in a way that increases the risk and impact of migraine.
  
  
  CONCLUSIONS
  We suggest a synergistic association between HNMT and DAO functional polymorphisms and migraine; this hypothesis must be further confirmed by larger studies. However, the characteristics and ethnic differences between analysed populations should be considered when interpreting the results.
authors.affiliation: Facultad de Medicina, Departamento de Investigación, Universidad Juárez del Estado de Durango, Campus Gómez Palacio, Durango, México; Secretaría de Salud, Centro de Atención a Metales Pesados, Torreón, Coahuila, México.
authors.forename: R
authors.initials: R
authors.lastname: Meza-Velázquez
authors.affiliation: Facultad de Medicina, Centro de Investigación Biomédica, Universidad Autónoma de Coahuila, Torreón, Coahuila, México.
authors.forename: F
authors.initials: F
authors.lastname: López-Márquez
authors.affiliation: Instituto Nacional de Pediatría, Departamento de Inmunodeficiencias, México, DF, México.
authors.forename: S
authors.initials: S
authors.lastname: Espinosa-Padilla
authors.affiliation: Facultad de Medicina, Centro de Investigación Biomédica, Universidad Autónoma de Coahuila, Torreón, Coahuila, México; Secretaría de Salud, Centro de Atención a Metales Pesados, Torreón, Coahuila, México.
authors.forename: M
authors.initials: M
authors.lastname: Rivera-Guillen
authors.affiliation: Facultad de Medicina, Centro de Investigación Biomédica, Universidad Autónoma de Coahuila, Torreón, Coahuila, México.
authors.forename: J
authors.initials: J
authors.lastname: Ávila-Hernández
authors.affiliation: Facultad de Medicina, Departamento de Investigación, Universidad Juárez del Estado de Durango, Campus Gómez Palacio, Durango, México. Electronic address: manuel_rosales_9@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Rosales-González
mesh_terms: D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006632:Histamine / Q000378:metabolism; D006637:Histamine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D008800:Mexico; D008881:Migraine Disorders / Q000175:diagnosis / Q000235:genetics*; D009035:Mothers; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D006637:Histamine N-Methyltransferase
keywords: ABP1; Diamine oxidase; Diaminoxidasa; Histamina; Histamina N-metiltransferasa; Histamine; Histamine N-methyltransferase; Migraine; Migraña; Polimorfismos; Polymorphism