title: Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity?
abstract: Numerous studies have documented a link between psychological disorders and cardiac disease. Yet, no systematic attempts have been made to develop pharmacological approaches for mood and anxiety disorders that could also be beneficial for cardiac health. The endocannabinoid system has been implicated in the regulation of stress, emotional behavior and cardiovascular function. General preclinical findings indicate that the endocannabinoid anandamide modulates physiological and behavioral stress responses and may also protect the heart from arrhythmias. Moreover, recent experimental studies suggest that pharmacological enhancement of anandamide signaling via inhibition of its degrading enzyme fatty acid amide hydrolase (FAAH) exerts anxiolytic- and antidepressive-like effects and improves cardiac autonomic function and the electrical stability of the myocardium in rodent models that reproduce aspects of human psychological/cardiac comorbidity. Here we summarize and discuss such experimental findings, which might guide future preclinical studies towards a systematic evaluation of the therapeutic potential of pharmacological approaches that target FAAH activity for the treatment of the comorbidity between psychological disorders and cardiac disease.
authors.affiliation: Department of Neuroscience, University of Parma, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Carnevali
authors.affiliation: Department of Pharmacy, University of Parma, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Rivara
authors.affiliation: School of Biomedical Sciences, University of Newcastle, Australia.
authors.forename: Eugene
authors.initials: E
authors.lastname: Nalivaiko
authors.affiliation: Department of Psychology, The Ohio State University, Columbus, OH, USA.
authors.forename: Julian F
authors.initials: JF
authors.lastname: Thayer
authors.affiliation: Department of Pharmacy, University of Parma, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Vacondio
authors.affiliation: Department of Pharmacy, University of Parma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Mor
authors.affiliation: Department of Neuroscience, University of Parma, Italy. Electronic address: andrea.sgoifo@unipr.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sgoifo
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001008:Anxiety Disorders; D015897:Comorbidity; D063388:Endocannabinoids; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D009206:Myocardium; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D000099252:Fatty Acid Amide Hydrolases
keywords: Anandamide; Anxiety; Arrhythmias; Autonomic nervous system; Cardiovascular disease; Depression; FAAH; Stress