title: Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities.
abstract: Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week period, changes in blood glucose and body weight were monitored. Then, rats were sacrificed and subjected to the assessment of changes in the reactivity of aortas and measurement of butyrylcholinesterase activity. To complete the panel of experiments, α-glucosidase activity was assessed in vitro. Our results demonstrate that both tested extracts exert similar anti-diabetic activities. However, better anti-oxidant activity of the A. eupatoria extract indicates its higher clinical potential in the prevention and/or adjuvant therapy of developing cardiovascular complications related to DM and diseases associated with oxidative stress.
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia. kuczmannova@fpharm.uniba.sk.
authors.forename: Anika
authors.initials: A
authors.lastname: Kuczmannová
authors.affiliation: Department of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, Bratislava 83232, Slovakia. balazova@fpharm.uniba.sk.
authors.forename: Andrea
authors.initials: A
authors.lastname: Balažová
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia. racanska@fpharm.uniba.sk.
authors.forename: Eva
authors.initials: E
authors.lastname: Račanská
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia. kamenikova@fpharm.uniba.sk.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Kameníková
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia. fialova@fpharm.uniba.sk.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fialová
authors.affiliation: Department of Medical Informatics, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, Košice 04011, Slovakia. jaroslav.majernik@upjs.sk.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Majerník
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia. nagy@fpharm.uniba.sk.
authors.forename: Milan
authors.initials: M
authors.lastname: Nagy
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia. pgal@vusch.sk.|Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, Košice 04011, Slovakia. pgal@vusch.sk.|Department for Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Ondavská 8, Košice 04011, Slovakia. pgal@vusch.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Gál
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia. mucaji@fpharm.uniba.sk.
authors.forename: Pavel
authors.initials: P
authors.lastname: Mučaji
mesh_terms: D031981:Agrimonia / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002091:Butyrylcholinesterase / Q000378:metabolism; D031942:Cynara / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; D002091:Butyrylcholinesterase
keywords: agrimony; artichoke; diabetes mellitus; phytotherapy; streptozotocin