title: Pharmacological DNA demethylation: Implications for cancer immunotherapy.
abstract: Recent studies have demonstrated that DNA demethylation agents can mimic a viral infection by induction of dsRNAs. This viral mimicry leads to an antiviral response mediated by the cytosolic pattern recognition receptor MDA5, followed by MAVS (IPS1) activation, IRF7 nuclear translocation and upregulation of type III Interferon and interferon-stimulated genes.
authors.affiliation: Princess Margaret Cancer Center, University Health Network , Toronto, ON, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Roulois
authors.affiliation: Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors.forename: Helen Loo
authors.initials: HL
authors.lastname: Yau
authors.affiliation: Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: De Carvalho
keywords: 5-AZA-CdR; DNA methylation; colorectal cancer; decitabine; epigenetic therapy