title: A short bout of HFD promotes long-lasting hepatic lipid accumulation.
abstract: A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.
authors.affiliation: Division of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland; Department of Drug Science and Technology; University of Turin; Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Chiazza
authors.affiliation: Division of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland.
authors.forename: Tenagne D
authors.initials: TD
authors.lastname: Challa
authors.affiliation: Division of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland; ZurichCenter for Integrative Human Physiology; University of Zurich; Zurich, Switzerland.
authors.forename: Fabrizio C
authors.initials: FC
authors.lastname: Lucchini
authors.affiliation: Division of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland; ZurichCenter for Integrative Human Physiology; University of Zurich; Zurich, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Konrad
authors.affiliation: Division of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland.
authors.forename: Stephan
authors.initials: S
authors.lastname: Wueest
keywords: diabetes mellitus; insulin resistance; liver; portal hypothesis; steatosis