title: Weak O-Assistance Outcompeting Strong N,N-Bidentate Directing Groups in Copper-Catalyzed C-H Chalcogenation.
abstract: A copper-mediated C-H chalcogenation of triazoles has been achieved by weak coordination. The user-friendly protocol showed high functional-group tolerance and ample substrate scope, yielding fully substituted 1,2,3-triazoles with complete positional site-selectivity. The C-H selenylation could likewise be achieved by means of copper catalysis. Our findings highlight for the first time that weak O-coordination can outcompete the strong N,N-bidentate coordination mode in C-H functionalization technology.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstraße 2, 37077, Göttingen, Germany.
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Cera
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstraße 2, 37077, Göttingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de.
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
keywords: C−H activation; copper; selenylation; sulfenylation; triazoles