title: Mouse Models for Studying Depression-Like States and Antidepressant Drugs.
abstract: Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice, and their utility in screening antidepressant drugs.
authors.affiliation: Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC, 20057, USA.
authors.forename: Carisa L
authors.initials: CL
authors.lastname: Bergner
authors.affiliation: Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC, 20057, USA.
authors.forename: Amanda N
authors.initials: AN
authors.lastname: Smolinsky
authors.affiliation: Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC, 20057, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Hart
authors.affiliation: Department of Animal Sciences, Purdue University, 915 W State St., West Lafayette, IN, 47907, USA.
authors.forename: Brett D
authors.initials: BD
authors.lastname: Dufour
authors.affiliation: Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC, 20057, USA.
authors.forename: Rupert J
authors.initials: RJ
authors.lastname: Egan
authors.affiliation: Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC, 20057, USA.|Stress Physiology and Research Center (SPaRC), Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC, 20057, USA.
authors.forename: Justin L
authors.initials: JL
authors.lastname: LaPorte
authors.affiliation: Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC, 20057, USA. avkalueff@gmail.com.|Stress Physiology and Research Center (SPaRC), Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC, 20057, USA. avkalueff@gmail.com.|Department of Pharmacology, Tulane University Medical Center, 830 Tulane Avenue, New Orleans, LA, 70112, USA. avkalueff@gmail.com.|Department of Physiology and Biophysics, Georgetown University Medical School, Basic Science Building, Room 254, 3900 Reservoir Road, Washington, DC, 20057, USA. avkalueff@gmail.com.|Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, 340111, China. avkalueff@gmail.com.|Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, 196310, Russia. avkalueff@gmail.com.|ZENEREI Research Center, Slidell, LA, 70458, USA. avkalueff@gmail.com.|Chemicotechnological Institute, Ural Federal State University , Ekaterinburg, 620002, Russia. avkalueff@gmail.com.
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
mesh_terms: D000818:Animals; D000928:Antidepressive Agents; D001522:Behavior, Animal; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009483:Neuropsychological Tests
chemical_list: D000928:Antidepressive Agents
keywords: Anhedonia; Animal models; Antidepressant drug screening; Chronic stress; Depression; Despair