title: [Prevalence of acetylsalicylic acid (ASA) - low response in vascular surgery].
abstract: BACKGROUND
  Research has revealed that a decreased antiplatelet effect (low response [LR]/high on-treatment platelet reactivity [HPR]) of acetylsalicylic acid (ASA) and clopidogrel is associated with an increased risk of thromboembolic events. There are extensive ASA low response (ALR) and clopidogrel low response (CLR) prevalence data in the literature, but there are only a few studies concerning vascular surgical patients. The aim of this study was to examine the prevalence and risk factors of ALR and CLR in vascular surgical patients.
  
  
  METHODS
  We examined n = 154 patients with an antiplatelet long-term therapy, who were treated due to peripheral artery occlusive disease (PAD) and/or arteria carotis interna stenosis (CVD). To detect an ALR or CLR, we examined full blood probes with impedance aggregometry (ChronoLog® Aggregometer model 590). Risk factors were examined by acquisition of concomitant disease, severity of vascular disease, laboratory test results and medication.
  
  
  RESULTS
  We found a prevalence of 19.3 % in the ALR group and of 21.1 % in the CLR group. Risk factors for ALR were an increased platelet and leucocyte count and co-medication with pantoprazole. We found no significant risk factors for a decreased antiplatelet effect of clopidogrel treatment.
  
  
  CONCLUSIONS
  The investigated prevalence for ALR and CLR are in the range of other studies, particularly based on cardiological patients. More investigations are needed to gain a better evaluation of the risk factors for HPR and to develop an effective antiplatelet therapy regime to prevent cardiovascular complications.
authors.affiliation: Klinik für Gefäßchirurgie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland. thomas.hummel@rub.de.
authors.forename: T
authors.initials: T
authors.lastname: Hummel
authors.affiliation: Klinik für Neurologie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
authors.forename: S H
authors.initials: SH
authors.lastname: Meves
authors.affiliation: Klinik für Gefäßchirurgie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Rüdiger
authors.affiliation: Klinik für Kardiologie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Mügge
authors.affiliation: Klinik für Gefäßchirurgie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Mumme
authors.affiliation: Klinik für Gefäßchirurgie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Burkert
authors.affiliation: Klinik für Gefäßchirurgie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Mühlberger
authors.affiliation: Klinik für Kardiologie, St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Neubauer
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000009:adverse effects / Q000627:therapeutic use; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000188:drug therapy*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D016893:Carotid Stenosis / Q000097:blood / Q000188:drug therapy*; D000077144:Clopidogrel; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D000077402:Pantoprazole; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood* / Q000517:prevention & control*; D012307:Risk Factors; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D000077402:Pantoprazole; D013988:Ticlopidine; D001241:Aspirin
keywords: ASA; Aggregometry; Clopidogrel; High on-treatment platelet reactivity; Low Response