title: Polypharmacology in Drug Development: A Minireview of Current Technologies.
abstract: Polypharmacology, the process in which a single drug is able to bind to multiple targets specifically and simultaneously, is an emerging paradigm in drug development. The potency of a given drug can be increased through the engagement of multiple targets involved in a certain disease. Polypharmacology may also help identify novel applications of existing drugs through drug repositioning. However, many problems and challenges remain in this field. Rather than covering all aspects of polypharmacology, this Minireview is focused primarily on recently reported techniques, from bioinformatics technologies to cheminformatics approaches as well as text-mining-based methods, all of which have made significant contributions to the research of polypharmacology.
authors.affiliation: Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.|The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 77030, USA.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Rajan
authors.initials: R
authors.lastname: Chaudhai
authors.affiliation: Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. shuzhang@mdanderson.org.|The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 77030, USA. shuzhang@mdanderson.org.
authors.forename: Shuxing
authors.initials: S
authors.lastname: Zhang
mesh_terms: D001665:Binding Sites; D019295:Computational Biology; D006801:Humans; D008024:Ligands; D062105:Molecular Docking Simulation; D064798:Polypharmacology; D021281:Quantitative Structure-Activity Relationship; D012984:Software
chemical_list: D008024:Ligands
keywords: bioinformatics; cheminformatics; drug development; polypharmacology