title: Antiplasmodial and Cytotoxic Activity of Raw Plant Extracts as Reported by Knowledgeable Indigenous People of the Amazon Region (Vaupés Medio in Colombia).
abstract: The in vitro antiplasmodial activity of 122 raw extracts prepared in ethanol and water from 35 medicinal plants reported by the Cubeo indigenous village of the Amazon region (Vaupés Medio in Colombia) was evaluated for efficacy against 3D7 (sensitive to chloroquine) and FCR-3 (resistant to chloroquine) Plasmodium falciparum strains. Five percent of these extracts presented a significant antiplasmodial activity (< 5 µg/mL) and 83 % of them were not cytotoxic. These findings highlight the importance of investigating traditional medicinal plants implemented by these ancestral communities of the Amazon region as well as their potential to become a source of new drugs against malaria.
authors.affiliation: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Pabón
authors.affiliation: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Otoniel
authors.initials: O
authors.lastname: Ramirez
authors.affiliation: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Ríos
authors.affiliation: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Ena
authors.initials: E
authors.lastname: López
authors.affiliation: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Briegel
authors.initials: B
authors.lastname: de Las Salas
authors.affiliation: Herbario Universidad de Antioquia, Medellín, Colombia.
authors.forename: Felipe
authors.initials: F
authors.lastname: Cardona
authors.affiliation: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Silvia
authors.initials: S
authors.lastname: Blair
mesh_terms: D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D003105:Colombia; D056945:Hep G2 Cells; D006801:Humans; D007199:Indians, South American; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D010936:Plant Extracts