title: ESCRT machinery: Damage control at the nuclear membrane.
abstract: Rupture of the nuclear envelope (NE) during interphase is thought to be an infrequent event in healthy cells. Two papers recently published in Science describe the transient disruption of the NE continuity in cells migrating through confined spaces, and uncover an essential role for the Endosomal Sorting Complex Required for Transport (ESCRT) machinery in the resealing of these nuclear discontinuities.
authors.affiliation: Department of Infectious Diseases, King's College London, London SE1 9RT, UK.
authors.forename: Leandro N
authors.initials: LN
authors.lastname: Ventimiglia
authors.affiliation: Department of Infectious Diseases, King's College London, London SE1 9RT, UK.
authors.forename: Juan
authors.initials: J
authors.lastname: Martin-Serrano
mesh_terms: D016923:Cell Death; D002465:Cell Movement; D004249:DNA Damage; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics*; D009685:Nuclear Envelope
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport