title: The Role of the IL-12 polymorphism rs3212227 in preeclampsia in Chinese Han Women.
abstract: OBJECTIVE
  To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women.
  
  
  METHODS
  We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR-restriction fragment length polymorphism.
  
  
  RESULTS
  No significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ(2) = 4.62, p = 0.10 by genotype; χ(2) = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups.
  
  
  CONCLUSIONS
  Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.
authors.affiliation: a Obstetrical Department , Maternal and Child Health Care of Zaozhuang , Zaozhuang , China.
authors.forename: Xibing
authors.initials: X
authors.lastname: Wang
authors.affiliation: b Department of Blood Transfusion , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Mingzhen
authors.initials: M
authors.lastname: Guo
authors.affiliation: c Biology Department , The Medical College of Qingdao University , Qingdao , China.
authors.forename: Sai
authors.initials: S
authors.lastname: Li
authors.affiliation: d Department of Clinical Laboratory , Chongqing Health for Women and Children , Chongqing , China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Gong
authors.affiliation: e Department of Clinical Laboratory , Qingdao Municipal Hospital (Group) , Qingdao , China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Song
authors.affiliation: b Department of Blood Transfusion , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: f Prenatal Diagnosis Center , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000235:genetics; D011247:Pregnancy
chemical_list: C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40
keywords: Genetics; IL-12; polymorphism; preeclampsia; susceptibility