title: Challenges in tissue engineering - towards cell control inside artificial scaffolds.
abstract: Control of living cells is vital for the survival of organisms. Each cell inside an organism is exposed to diverse external mechano-chemical cues, all coordinated in a spatio-temporal pattern triggering individual cell functions. This complex interplay between external chemical cues and mechanical 3D environments is translated into intracellular signaling loops. Here, we describe how external mechano-chemical cues control cell functions, especially cell migration, and influence intracellular information transport. In particular, this work focuses on the quantitative analysis of (1) intracellular vesicle transport to understand intracellular state changes in response to external cues, (2) cellular sensing of external chemotactic cues, and (3) the cells' ability to migrate in 3D structured environments, artificially fabricated to mimic the 3D environment of tissue in the human body.
authors.affiliation: Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, 97082 Würzburg, Germany. heinrich@physics.leidenuniv.nl and Julius-Maximilians University Würzburg, Chemical Technology of Material Synthesis, Röntgenring 11, 97070 Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Emmert
authors.affiliation: Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, 97082 Würzburg, Germany. heinrich@physics.leidenuniv.nl and Julius-Maximilians University Würzburg, Chemical Technology of Material Synthesis, Röntgenring 11, 97070 Würzburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Witzel
authors.affiliation: Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, 97082 Würzburg, Germany. heinrich@physics.leidenuniv.nl and Leiden Institute of Physics LION, Leiden University, Niels Bohrweg 2, 2333 CA Leiden, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Heinrich
mesh_terms: D002465:Cell Movement; D002633:Chemotaxis; D006801:Humans; D015398:Signal Transduction; D023822:Tissue Engineering; D054457:Tissue Scaffolds