title: Matrine: Bioactivities and Structural Modifications.
abstract: Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.
authors.forename: Jiulin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, P. R. China. orgxuhui@nwsuaf.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D011807:Quinolizines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D000093842:Matrines
chemical_list: D000470:Alkaloids; D011807:Quinolizines; D000093842:Matrines