title: Update on the Management of Aspirin-Exacerbated Respiratory Disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) is an adult-onset upper and lower airway disease consisting of eosinophilic nasal polyps, asthma, and respiratory reactions to cyclooxygenase 1 (COX-1) inhibitors. Management includes guideline-based treatment of asthma and sinus disease, avoidance of COX-1 inhibitors, and for some patients aspirin desensitization followed by high-dose aspirin therapy. Despite this, many patients have inadequately controlled symptoms and require multiple sinus surgeries. In this review, we discuss the current standard approaches to the management of AERD, and we introduce several therapeutics under development that may hold promise for the treatment of AERD.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, MA, USA.|Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA. kbuchheit@partners.org.
authors.forename: Kathleen M
authors.identifier: http://orcid.org/0000-0001-5977-851X
authors.initials: KM
authors.lastname: Buchheit
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, MA, USA.|Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Laidlaw
keywords: Aspirin-exacerbated respiratory disease; Samter's triad; aspirin desensitization; nasal polyps