title: Manganese-Mediated C-H Alkylation of Unbiased Arenes Using Alkylboronic Acids.
abstract: The alkylation of arenes is an essential synthetic step of interest not only from the academic point of view but also in the bulk chemical industry. Despite its limitations, the Friedel-Crafts reaction is still the method of choice for most of the arene alkylation processes. Thus, the development of new strategies to synthesize alkyl arenes is a highly desirable goal, and herein, we present an alternative method to those conventional reactions. Particularly, a simple protocol for the direct C-H alkylation of unbiased arenes with alkylboronic acids in the presence of Mn(OAc)3 ⋅2H2 O is reported. Primary or secondary unactivated alkylboronic acids served as alkylating agents for the direct functionalization of representative polyaromatic hydrocarbons (PAHs) or benzene. The results are consistent with a free-radical mechanism.
authors.affiliation: Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, Julián Clavería, 8, 33006, Oviedo, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Castro
authors.affiliation: R&D Department, Industrial Química del Nalón S. A., Avenida de Galicia, 31, 33005, Oviedo, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Fernández
authors.affiliation: Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, Julián Clavería, 8, 33006, Oviedo, Spain. fjfv@uniovi.es.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Fañanás
authors.affiliation: Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, Julián Clavería, 8, 33006, Oviedo, Spain. vicenteruben@uniovi.es.
authors.forename: Rubén
authors.initials: R
authors.lastname: Vicente
authors.affiliation: Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, Julián Clavería, 8, 33006, Oviedo, Spain. frodriguez@uniovi.es.
authors.forename: Félix
authors.initials: F
authors.lastname: Rodríguez
keywords: arenes; boronic acids; manganese; synthetic methods