title: Functional connectivity dynamics during film viewing reveal common networks for different emotional experiences.
abstract: Recent theoretical and empirical work has highlighted the role of domain-general, large-scale brain networks in generating emotional experiences. These networks are hypothesized to process aspects of emotional experiences that are not unique to a specific emotional category (e.g., "sadness," "happiness"), but rather that generalize across categories. In this article, we examined the dynamic interactions (i.e., changing cohesiveness) between specific domain-general networks across time while participants experienced various instances of sadness, fear, and anger. We used a novel method for probing the network connectivity dynamics between two salience networks and three amygdala-based networks. We hypothesized, and found, that the functional connectivity between these networks covaried with the intensity of different emotional experiences. Stronger connectivity between the dorsal salience network and the medial amygdala network was associated with more intense ratings of emotional experience across six different instances of the three emotion categories examined. Also, stronger connectivity between the dorsal salience network and the ventrolateral amygdala network was associated with more intense ratings of emotional experience across five out of the six different instances. Our findings demonstrate that a variety of emotional experiences are associated with dynamic interactions of domain-general neural systems.
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Steve Tisch School of Film and Television, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Raz
authors.affiliation: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.|MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Touroutoglou
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.|Department of Psychology, Northeastern University, 125 Nightingale Hall, Boston, MA, 02115-5000, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Wilson-Mendenhall
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gadi
authors.initials: G
authors.lastname: Gilam
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Tamar
authors.initials: T
authors.lastname: Lin
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Gonen
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Jacob
authors.affiliation: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.|Department of Psychology, Northeastern University, 125 Nightingale Hall, Boston, MA, 02115-5000, USA.
authors.forename: Shir
authors.initials: S
authors.lastname: Atzil
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
authors.forename: Roee
authors.initials: R
authors.lastname: Admon
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Bleich-Cohen
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Maron-Katz
authors.affiliation: The Tel Aviv Center for Brain Functions, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Talma
authors.initials: T
authors.lastname: Hendler
authors.affiliation: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. l.barrett@neu.edu.|Department of Psychology, Northeastern University, 125 Nightingale Hall, Boston, MA, 02115-5000, USA. l.barrett@neu.edu.|Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. l.barrett@neu.edu.
authors.forename: Lisa Feldman
authors.initials: LF
authors.lastname: Barrett
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D004644:Emotions / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology*; D017711:Nonlinear Dynamics; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Amygdala; Emotions; Network cohesion; Stimulus-induced functional connectivity