title: 3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study.
abstract: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.
  
  
  
  A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.
  
  
  
  Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2, females: -3.1 ± 0.8 ml/m2; ESVI males: -1.3 ± 0.7 ml/m2, females: -1.7 ± 0.5 ml/m2; SVI males: -1.7 ± 0.9 ml/m2, females: -1.4 ± 0.6 ml/m2; LVMI males: -1.6 ± 1.1 g/m2, females: -0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.
  
  
  
  LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners. J. Magn. Reson. Imaging 2016;44:1186-1196.
authors.affiliation: NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, UK.|NHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gandy
authors.affiliation: University of Dundee School of Medicine, Dundee, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Lambert
authors.affiliation: University of Dundee School of Medicine, Dundee, UK.
authors.forename: Jill
authors.initials: J
authors.lastname: Belch
authors.affiliation: NHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Cavin
authors.affiliation: NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, UK.
authors.forename: Elena
authors.initials: E
authors.lastname: Crowe
authors.affiliation: University of Dundee School of Medicine, Dundee, UK.
authors.forename: Roberta
authors.initials: R
authors.lastname: Littleford
authors.affiliation: NHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: MacFarlane
authors.affiliation: University of Dundee School of Medicine, Dundee, UK.
authors.forename: Shona Z
authors.initials: SZ
authors.lastname: Matthew
authors.affiliation: NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, UK.
authors.forename: Patricia
authors.initials: P
authors.lastname: Martin
authors.affiliation: NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, UK.|NHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
authors.forename: R Stephen
authors.initials: RS
authors.lastname: Nicholas
authors.affiliation: University of Dundee School of Medicine, Dundee, UK.
authors.forename: Allan
authors.initials: A
authors.lastname: Struthers
authors.affiliation: Department of Family and Community Medicine, University of Toronto, Toronto, Canada.|Department of Research and Innovation, North York General Hospital, Toronto, Canada.
authors.forename: Frank
authors.initials: F
authors.lastname: Sullivan
authors.affiliation: NHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Waugh
authors.affiliation: NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, UK.|Department of Clinical Radiology, University Hospital of Wales, UK.
authors.forename: Richard D
authors.initials: RD
authors.lastname: White
authors.affiliation: University of Dundee School of Medicine, Dundee, UK.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Weir-McCall
authors.affiliation: NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, UK. ghouston@nhs.net.|University of Dundee School of Medicine, Dundee, UK. ghouston@nhs.net.
authors.forename: J Graeme
authors.initials: JG
authors.lastname: Houston
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012016:Reference Values; D017678:Sex Distribution; D012737:Sex Factors; D013318:Stroke Volume / Q000502:physiology*; D006113:United Kingdom / Q000453:epidemiology; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: 3.0T; MRI; cardiac; left ventricle; population