title: Analysis of expression of PTEN/PI3K pathway and programmed cell death ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM).
abstract: Malignant pleural mesothelioma (MPM) frequently express elevated AKT/mTOR activity. Previous reports in gliomas, colon, breast and prostate cancer suggest that PTEN/PI3K pathway may be important for the induction of PD-L1 expression. This study explored the expression of PTEN/PI3K pathway and PD-L1 in MPM and its relationship with the patient́s prognosis
  
  
  
  Twenty seven consecutive MPM patients were reviewed. Formalin-fixed, paraffin-embedded tissue biopsies were used for immunohistochemical analysis of PTEN/PI3K pathway and PD-L1 RESULTS: Expression of PTEN, mTOR, pAKT, p4EBP1, peif4E, pS6 and FOXO3a was found in 88.5%, 92.3%, 78.3%, 38.5%, 100%, 52.2% and 100% of tumors and PD-L1 in 23%. We found a significant correlation between pAKT, FOXO3a and PD-L1 expression and longer overall survival (p <0.05). We did not identify significant association between the level of PD-L1 expression and alterations in PI3K pathway
  
  
  
  This study shows PTEN/PI3K pathway and PD-L1 in MPM are frequently activated. Our results suggests that there is not association between PD-L1 and the involvement of the PI3K pathway in MPM.
authors.affiliation: Medical Oncology Service, Vall d́Hebron Institute Oncology, Vall d'Hebron University Hospital, Barcelona, Spain; Universidad Autonoma de Barcelona, Barcelona, Spain. Electronic address: scedres@vhebron.net.
authors.forename: S
authors.initials: S
authors.lastname: Cedrés
authors.affiliation: Medical Oncology Service, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Ponce-Aix
authors.affiliation: Medical Oncology Service, Vall d́Hebron Institute Oncology, Vall d'Hebron University Hospital, Barcelona, Spain; Universidad Autonoma de Barcelona, Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Pardo-Aranda
authors.affiliation: Medical Oncology Service, Vall d́Hebron Institute Oncology, Vall d'Hebron University Hospital, Barcelona, Spain; Universidad Autonoma de Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Navarro-Mendivil
authors.affiliation: Medical Oncology Service, Vall d́Hebron Institute Oncology, Vall d'Hebron University Hospital, Barcelona, Spain; Universidad Autonoma de Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Martinez-Marti
authors.affiliation: Medical Oncology Service, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Zugazagoitia
authors.affiliation: Pathology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Sansano
authors.affiliation: Pathology Department, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Montoro
authors.affiliation: Pathology Department, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Enguita
authors.affiliation: Medical Oncology Service, Vall d́Hebron Institute Oncology, Vall d'Hebron University Hospital, Barcelona, Spain; Universidad Autonoma de Barcelona, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Felip
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060890:B7-H1 Antigen / Q000096:biosynthesis / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D000071316:Forkhead Box Protein O3 / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000201:enzymology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000096:biosynthesis / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000096:biosynthesis / Q000378:metabolism*; D010997:Pleural Neoplasms / Q000201:enzymology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
chemical_list: D060890:B7-H1 Antigen; D014408:Biomarkers, Tumor; D000071316:Forkhead Box Protein O3; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; C423236:CD274 protein, human; C499517:FOXO3 protein, human; C494929:PTEN protein, human
keywords: Malignant pleural mesothelioma; PD-L1; PI3K; Prognostic factor