title: An integrated signal transduction network of macrophage migration inhibitory factor.
abstract: Macrophage migration inhibitory factor (MIF) is a glycosylated multi-functional protein that acts as an enzyme as well as a cytokine. MIF mediates its actions through a cell surface class II major histocompatibility chaperone, CD74 and co-receptors such as CD44, CXCR2, CXCR4 or CXCR7. MIF has been implicated in the pathogenesis of several acute and chronic inflammatory diseases. Although MIF is a molecule of biomedical importance, a public resource of MIF signaling pathway is currently lacking. In view of this, we carried out detailed data mining and documentation of the signaling events pertaining to MIF from published literature and developed an integrated reaction map of MIF signaling. This resulted in the cataloguing of 68 molecules belonging to MIF signaling pathway, which includes 24 protein-protein interactions, 44 post-translational modifications, 11 protein translocation events and 8 activation/inhibition events. In addition, 65 gene regulation events at the mRNA levels induced by MIF signaling have also been catalogued. This signaling pathway has been integrated into NetPath ( http://www.netpath.org ), a freely available human signaling pathway resource developed previously by our group. The MIF pathway data is freely available online in various community standard data exchange formats. We expect that data on signaling events and a detailed signaling map of MIF will provide the scientific community with an improved platform to facilitate further molecular as well as biomedical investigations on MIF.
authors.affiliation: Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, 560066, India.|Amrita School of Biotechnology, Amrita University, Kollam, 690525, India.
authors.forename: Tejaswini
authors.initials: T
authors.lastname: Subbannayya
authors.affiliation: Armed Forces Medical College, Pune, 411040, India.
authors.forename: Prathyaksha
authors.initials: P
authors.lastname: Variar
authors.affiliation: Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, 560066, India.|Manipal University, Madhav Nagar, Manipal, 576104, India.
authors.forename: Jayshree
authors.initials: J
authors.lastname: Advani
authors.affiliation: Amrita School of Biotechnology, Amrita University, Kollam, 690525, India.
authors.forename: Bipin
authors.initials: B
authors.lastname: Nair
authors.affiliation: Command Hospital (Air Force), Bangalore, 560007, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Shankar
authors.affiliation: Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, 560066, India.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India.
authors.forename: Harsha
authors.initials: H
authors.lastname: Gowda
authors.affiliation: Laboratory of Anatomy and Cell Biology, Faculty of Medicine and Pharmacy, University of Mons, B-7000, Mons, Belgium.
authors.forename: Sven
authors.initials: S
authors.lastname: Saussez
authors.affiliation: Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, 560066, India. aditi@ibioinformatics.org.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India. aditi@ibioinformatics.org.
authors.forename: Aditi
authors.initials: A
authors.lastname: Chatterjee
authors.affiliation: Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, 560066, India. keshav@ibioinformatics.org.|Amrita School of Biotechnology, Amrita University, Kollam, 690525, India. keshav@ibioinformatics.org.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India. keshav@ibioinformatics.org.|NIMHANS-IOB Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India. keshav@ibioinformatics.org.
authors.forename: T S Keshava
authors.initials: TS
authors.lastname: Prasad
keywords: Immune response; Inflammation; NetSlim; Post-translational modifications; Pro-inflammatory cytokine; Protein-protein interactions