title: Analysis of association of FOXO3 gene with Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy.
abstract: FOXO3, a member of the Forkhead family of proteins, plays a role in controlling immune response. FOXO3 gene variant rs12212067 has been associated to differential severity of infectious diseases like malaria. In this study, we assessed whether this FOXO3 gene polymorphism is related to susceptibility to infection by Trypanosoma cruzi and/or chronic Chagasic cardiomyopathy. A total of 1171 individuals from a Colombian region endemic for Chagas disease, classified as seronegative (n = 595), seropositive asymptomatic (n = 175) and chronic Chagasic cardiomyopathy (n = 401) were genotyped for the FOXO3 rs12212067 using TaqMan allelic discrimination. Our results showed no statistically significantly differences between allelic and genotypic frequencies of rs12212067 in seronegative individuals compared with seropositive individuals. Similarly, we observed no evidence of association when asymptomatic individuals were compared with chronic Chagasic cardiomyopathy patients. Our data suggest that the FOXO3 genetic variant rs12212067 do not play an important role in Chagas disease.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain.
authors.forename: D A
authors.initials: DA
authors.lastname: Leon Rodriguez
authors.affiliation: Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: C I
authors.initials: CI
authors.lastname: González
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martin
mesh_terms: D000328:Adult; D000483:Alleles; D058070:Asymptomatic Diseases; D002598:Chagas Cardiomyopathy / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D002908:Chronic Disease; D003105:Colombia / Q000453:epidemiology; D019353:Endemic Diseases; D005260:Female; D000071316:Forkhead Box Protein O3 / Q000235:genetics* / Q000276:immunology; D015870:Gene Expression; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014349:Trypanosoma cruzi / Q000276:immunology* / Q000472:pathogenicity
chemical_list: C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3
keywords: Chagas disease; FOXO3; genetics; rs12212067; single nucleotide polymorphism