title: Association between an anti-inflammatory and anti-oxidant dietary pattern and diabetes in British adults: results from the national diet and nutrition survey rolling programme years 1-4.
abstract: This study investigated the cross-sectional association between an anti-inflammatory and anti-oxidant dietary pattern and diabetes in the national diet and nutrition survey (NDNS) rolling programme years 1-4. A total of 1531 survey members provided dietary data. Reduced Rank Regression (RRR) was used to derive an anti-inflammatory and anti-oxidant dietary pattern. Serum C-reactive protein (CRP) and plasma carotenoids were selected as response variables and markers of inflammation and antioxidant status, respectively. Overall, 52 survey members had diabetes. The derived anti-inflammatory and anti-oxidant dietary pattern was inversely related to CRP and positively to carotenoids. It was associated with lower odds of diabetes (multivariate adjusted OR for highest compared with lowest quintile: 0.17; 95%CI: 0.04-0.73; p for linear trend = 0.013). In conclusion, an anti-inflammatory and anti-oxidant dietary pattern is inversely related to diabetes. Further research is required to understand the overall framework within which foods and nutrients interact to affect metabolic pathways related to diabetes risk.
authors.affiliation: a Faculty of Medical Sciences , Newcastle University , Newcastle upon Tyne , UK ;
authors.forename: L
authors.initials: L
authors.lastname: McGeoghegan
authors.affiliation: b Institute of Health & Society, Newcastle University , Newcastle upon Tyne , UK ;
authors.forename: C R
authors.initials: CR
authors.lastname: Muirhead
authors.affiliation: c Human Nutrition Research Centre and Institute of Health & Society, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: S
authors.initials: S
authors.lastname: Almoosawi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002338:Carotenoids / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000517:prevention & control*; D004032:Diet; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009749:Nutrition Surveys; D018384:Oxidative Stress / Q000187:drug effects; D055105:Waist Circumference
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002338:Carotenoids; D002097:C-Reactive Protein
keywords: C-reactive protein; Carotenoids; diet; dietary patterns; glycosylated haemoglobin; national diet and nutrition survey; nutritional epidemiology