title: Extracorporeal shockwave therapy promotes chondrogenesis in cartilage tissue engineering: A hypothesis based on previous evidence.
abstract: The dearth of intrinsic regenerative capacity of articular cartilage makes it a challenge to deal with the cartilage defects. Among all the recommended clinical options, cartilage tissue engineering (CTE) which is highlighted of dominant features and less drawbacks for functional cartilage restoration, has been emphasized recently. Shock waves, a mode of therapeutic mechanical forces, utilized in extracorporeal shockwave therapy (ESWT), is hypothesized to enhance proliferation, chondrogenic differentiation, and cartilage extracellular matrix production of target cells seeded on bioactive scaffolds. The hypothesis is firstly based on cellular mechanotransduction by which cells convent the shockwave mechanical signals into biochemical responses via integrins, iron channels, cytoskeletal filaments, growth factor receptors and nuclei. Secondly, by modulating gene expression and up-regulating the release of various growth factors which are of vital importance in three-dimensional cartilage culture environment, ESWT holds a promising potential to favor the cell sources (e.g. chondrocytes and stem cells) to mimic the optimal functional cartilage. In all, on the basis of cellular mechanotransduction and previous evidence, the hypothesis is developed to support the beneficial effects of ESWT on chondrogenesis in CTE. If this hypothesis is confirmed, shockwaves may allow a better success in combination with other stimulating factors for cartilage repair. There is a paucity of studies investigating the assistant role of shockwave stimulation in CTE. Further research is required to elucidate the mechanisms, and explore effectiveness and appropriate protocols of this novel stimulative factor in cartilage tissue engineering.
authors.affiliation: Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, People's Republic of China; Key Laboratory of Rehabilitation Medicine, Department in Sichuan, Chengdu 610041, Sichuan Province, People's Republic of China.
authors.forename: Qiaodan
authors.initials: Q
authors.lastname: Ji
authors.affiliation: Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, People's Republic of China; Key Laboratory of Rehabilitation Medicine, Department in Sichuan, Chengdu 610041, Sichuan Province, People's Republic of China. Electronic address: hxkfhcq_03@126.com.
authors.forename: Chengqi
authors.initials: C
authors.lastname: He
mesh_terms: D000818:Animals; D002356:Cartilage / Q000502:physiology*; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D019902:Chondrocytes / Q000166:cytology; D020219:Chondrogenesis; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008962:Models, Theoretical; D010003:Osteoarthritis / Q000378:metabolism; D011817:Rabbits; D012038:Regeneration; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D007501:Iron