title: Amplified effect of surface charge on cell adhesion by nanostructures.
abstract: Nano-biointerfaces with varied surface charge can be readily fabricated by integrating a template-based process with maleimide-thiol coupling chemistry. Significantly, nanostructures are employed for amplifying the effect of surface charge on cell adhesion, as revealed by the cell-adhesion performance, cell morphology and corresponding cytoskeletal organization. This study may provide a promising strategy for developing new biomedical materials with tailored cell adhesion for tissue implantation and regeneration.
authors.affiliation: Research Center for Bioengineering & Sensing Technology, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Xu
authors.forename: Jingxin
authors.initials: J
authors.lastname: Meng
authors.forename: Shuaitao
authors.initials: S
authors.lastname: Zhang
authors.forename: Xinlei
authors.initials: X
authors.lastname: Ma
authors.forename: Shutao
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion; D005347:Fibroblasts / Q000166:cytology; D051379:Mice; D041681:NIH 3T3 Cells; D049329:Nanostructures; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials