title: Deploying myeloid cells against myeloma.
abstract: Myeloma remains incurable despite recent therapeutic advances. We propose that minimal residual disease following cytoreductive therapy may be controlled through re-education of myeloid cells to elicit tumoricidal activity. We review work from our laboratory and others highlighting aspects of macrophage-myeloma cell crosstalk as well as strategies for therapeutic macrophage reprogramming.
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Jensen
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
authors.forename: Chelsea
authors.initials: C
authors.lastname: Hope
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
authors.forename: Fotis
authors.initials: F
authors.lastname: Asimakopoulos
keywords: CD40; immunotherapy; macrophages; myeloma