title: Paraneoplastic thrombocytosis in gastrointestinal cancer.
abstract: It has been demonstrated recently in several solid tumors that thrombocytosis at diagnosis may correlate with tumor invasion, metastatic progression and worse outcome. Several details of the pathomechanism of the relationship of thrombocytosis and cancer have been elucidated; however, the complete process is not clearly understood. Several hypotheses have been proposed. Recently, it was suggested that in ovarian cancer elevated IL-6 production by the tumor may induce increased megakaryopoiesis via hepatic thrombopoietin production leading to thrombocytosis. The importance of the prognostic power of elevated platelet count is still debated in gastrointestinal cancer. The aims of this review were to evaluate the prognostic significance of thrombocytosis in gastrointestinal tumors, to see whether clinical practice confirmed the hypotheses and to reveal the causes of the inconsistent findings.
authors.affiliation: a Department of Surgery , Semmelweis University Budapest , Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Baranyai
authors.affiliation: b Department of Otorhinolaryngology and Head and Neck Surgery, Flór Ferenc Hospital , Kistarcsa , Hungary.
authors.forename: Valéria
authors.initials: V
authors.lastname: Jósa
authors.affiliation: c Semmelweis University , Budapest , Hungary.
authors.forename: Ambrus
authors.initials: A
authors.lastname: Tóth
authors.affiliation: d Department of Otorhinolaryngology and Head and Neck Surgery , HDF Medical Centre , Budapest , Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Szilasi
authors.affiliation: a Department of Surgery , Semmelweis University Budapest , Hungary.
authors.forename: Balazs
authors.initials: B
authors.lastname: Tihanyi
authors.affiliation: a Department of Surgery , Semmelweis University Budapest , Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Zaránd
authors.affiliation: a Department of Surgery , Semmelweis University Budapest , Hungary.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Harsanyi
authors.affiliation: e Informatics Program, Children's Hospital , Harvard Medical School , Boston , MA , USA.|f Department of Systems Biology , Technical University of Denmark , Kgs Lyngby , Denmark.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szállási
mesh_terms: D000818:Animals; D018450:Disease Progression; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000473:pathology; D006801:Humans; D009362:Neoplasm Metastasis; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D010976:Platelet Count; D011183:Postoperative Complications; D015995:Prevalence; D011379:Prognosis; D013922:Thrombocytosis / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D034061:Thrombopoiesis
keywords: Gastrointestinal tumors; paraneoplastic; prognosis; survival; thrombocytosis