title: [Role of radiotherapy in the management of non-Hodgkin lymphomas].
abstract: The purpose of this review was to summarize recent data about lastest retrospective and prospective studies dealing with radiotherapy of non-Hodgkin lymphoma, in order to precise the schedule and the role of this treatment. A systematic review was done by searching studies on the website http://www.pubmed.gov (Medline) using the following keywords: radiotherapy, radiation therapy, non-Hodgkin lymphoma. The management of non-Hodgkin lymphoma varies a lot according to the histological type and stage. The dose of radiotherapy has been studied in only one randomized trial, which concluded that there was no difference between the low dose and the high dose arms. Radiotherapy is a very good option in follicular, cutaneous, digestive or orbital non-Hodgkin lymphoma. A recent post hoc analysis of randomized trials on radiotherapy for high-grade non-Hodgkin lymphoma strongly suggested a benefit of additional radiotherapy after chemotherapy in some situations. Radiotherapy of low-grade non-Hodgkin lymphoma is a very good option, while its use on high-grade non-Hodgkin lymphoma is sometimes recommended but further randomized trials are ongoing to better understand its role.
authors.affiliation: Département d'oncologie médicale, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: L
authors.initials: L
authors.lastname: Gastaud
authors.affiliation: Département d'oncologie et d'hématologie, centre hospitalier de la Dracénie, route de Montferrat, 83300 Draguignan, France.
authors.forename: B
authors.initials: B
authors.lastname: Rossignol
authors.affiliation: Département d'oncologie médicale, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: F
authors.initials: F
authors.lastname: Peyrade
authors.affiliation: Département de médecine interne, gastroentérologie, cancérologie et rhumatologie, centre hospitalier d'Antibes Juan-les-pins, quartier la Fontonne, 107, avenue de Nice, 06606 Antibes cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Ré
authors.affiliation: Département de radiothérapie, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: J
authors.initials: J
authors.lastname: Thariat
authors.affiliation: Département d'oncologie médicale, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: A
authors.initials: A
authors.lastname: Thyss
authors.affiliation: Département de radiothérapie, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06000 Nice, France. Electronic address: jerome.doyen@nice.unicancer.fr.
authors.forename: J
authors.initials: J
authors.lastname: Doyen
mesh_terms: D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000532:radiotherapy; D008224:Lymphoma, Follicular / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy*; D011446:Prospective Studies; D011878:Radiotherapy / Q000379:methods; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000532:radiotherapy
keywords: High-grade lymphoma; Low-grade lymphoma; Lymphome de bas grade; Lymphome de haut grade; Lymphome malin non hodgkinien; Non-Hodgkin lymphoma; Radiotherapy; Radiothérapie