title: Probable preventive effects of placenta from oxidative stress; Evaluation of total antioxidant status, total oxidant status and oxidative stress index in fetal cord blood during the delivery.
abstract: Depression in pregnancy may have negative effects on birth outcomes. It may also effect the intrauterine environment of the fetus. The umbilical cord is the conduit between the fetus and placenta, and functions in the transport between fetus and mother. Investigating biochemical parameters in fetal cord blood (FCB) during delivery may be helpful to understanding to what the fetus is exposed to, at least in the last trimester. In this study, we aimed to investigate total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in the FCB of depressed mothers and healthy controls during delivery. Our study included 33 depressed mothers and 37 healthy controls. TAS, TOS, and OSI were measured according to Erel's method. We found that TAS, TOS, and OSI levels were similar in patients and healthy controls; however, the birth weights of depressed patients were significantly lower than those of healthy controls. Our results suggest that the placental barrier may prevent from oxidative stress. Future studies should include blood samples collected simultaneously from mothers during delivery.
authors.affiliation: Afşin State Hospital, Psychiatry Clinic, Kahramanmaraş, Turkey. Electronic address: dr.akif@gmail.com.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Camkurt
authors.affiliation: Kahramanmaraş Sütçü İmam University, Psychiatry Clinic, Kahramanmaraş, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Fındıklı
authors.affiliation: Kahramanmaraş Sütçü İmam University, Biochemistry Department, Kahramanmaraş, Turkey.
authors.forename: Fatma İnanç
authors.initials: Fİ
authors.lastname: Tolun
authors.affiliation: Kahramanmaraş Sütçü İmam University, Obstetry Clinic, Kahramanmaraş, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Bakacak
authors.affiliation: Kahramanmaraş Sütçü İmam University, Psychiatry Clinic, Kahramanmaraş, Turkey.
authors.forename: Nilay Gül
authors.initials: NG
authors.lastname: Bal
authors.affiliation: Kahramanmaraş Sütçü İmam University, Obstetry Clinic, Kahramanmaraş, Turkey.
authors.forename: Hilal
authors.initials: H
authors.lastname: Sakallı
authors.affiliation: Dicle University Psychiatry Department, Diyarbakır, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Güneş
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001724:Birth Weight; D016022:Case-Control Studies; D036861:Delivery, Obstetric; D003863:Depression / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D009035:Mothers / Q000523:psychology; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology / Q000523:psychology
chemical_list: D000975:Antioxidants; D016877:Oxidants