title: INTRAUTERINE GROWTH RESTRICTION--PREDICTIVE SERUM MARKERS.
abstract: OBJECTIVE
  To determine during the first trimester of pregnancy some serum and ultrasound markers that could improve perinatal morbidity and mortality in women with intrauterine growth restriction (IUGR).
  
  
  METHODS
  Prospective study of pregnant women gestational age 11 weeks and 0 days--13 weeks and 6 days, consisting in the determination of pregnancy associated plasma protein (PAPP-A), mean platelet volume (MPV), and ultrasound appearance of placenta.
  
  
  CONCLUSIONS
  This study suggests that screening by detailed history and PAPP-A and MPV determination during the first trimester of pregnancy in women at risk for IUGR makes possible the prophylactic treatment and monitoring of pregnancy according to a given protocol and thus neonatal morbidity and mortality to be reduced.
authors.forename: Valeria
authors.initials: V
authors.lastname: Vişan
authors.forename: Ivona
authors.initials: I
authors.lastname: Anghelache-Lupaşcu
authors.forename: T
authors.initials: T
authors.lastname: Sălăvăscu
authors.forename: V
authors.initials: V
authors.lastname: Rugină
authors.forename: R
authors.initials: R
authors.lastname: Socolov
authors.forename: Demetra
authors.initials: D
authors.lastname: Socolov
authors.forename: A
authors.initials: A
authors.lastname: Cărăuleanu
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D063847:Mean Platelet Volume; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human