title: Saccharomyces cerevisiae UFMG A-905 treatment reduces intestinal damage in a murine model of irinotecan-induced mucositis.
abstract: Indigenous microbiota plays a crucial role in the development of several intestinal diseases, including mucositis. Gastrointestinal mucositis is a major and serious side effect of cancer therapy, and there is no effective therapy for this clinical condition. However, some probiotics have been shown to attenuate such conditions. To evaluate the effects of Saccharomyces cerevisiae UFMG A-905 (Sc-905), a potential probiotic yeast, we investigated whether pre- or post-treatment with viable or inactivated Sc-905 could prevent weight loss and intestinal lesions, and maintain integrity of the mucosal barrier in a mucositis model induced by irinotecan in mice. Only post-treatment with viable Sc-905 was able to protect mice against the damage caused by chemotherapy, reducing the weight loss, increase of intestinal permeability and jejunal lesions (villous shortening). Besides, this treatment reduced oxidative stress, prevented the decrease of goblet cells and stimulated the replication of cells in the intestinal crypts of mice with experimental mucositis. In conclusion, Sc-905 protects animals against irinotecan-induced mucositis when administered as a post-treatment with viable cells, and this effect seems to be related with the reduction of oxidative stress and preservation of intestinal mucosa.
authors.affiliation: 1 Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: R W
authors.initials: RW
authors.lastname: Bastos
authors.affiliation: 1 Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: S H S P
authors.initials: SH
authors.lastname: Pedroso
authors.affiliation: 1 Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: A T
authors.initials: AT
authors.lastname: Vieira
authors.affiliation: 1 Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: L M C
authors.initials: LM
authors.lastname: Moreira
authors.affiliation: 1 Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: C S
authors.initials: CS
authors.lastname: França
authors.affiliation: 2 Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: C T
authors.initials: CT
authors.lastname: Cartelle
authors.affiliation: 2 Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: R M E
authors.initials: RM
authors.lastname: Arantes
authors.affiliation: 3 Department of Basic Nursing, School of Nursing, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: S V
authors.initials: SV
authors.lastname: Generoso
authors.affiliation: 4 Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: V N
authors.initials: VN
authors.lastname: Cardoso
authors.affiliation: 5 Center of Nuclear Technology Development/Brazilian Nuclear Energy Commission (CDTN/CNEN), Belo Horizonte, MG, Brazil.
authors.forename: M J
authors.initials: MJ
authors.lastname: Neves
authors.affiliation: 1 Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: J R
authors.initials: JR
authors.lastname: Nicoli
authors.affiliation: 1 Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: F S
authors.initials: FS
authors.lastname: Martins
mesh_terms: D000818:Animals; D002166:Camptothecin / Q000031:analogs & derivatives; D004195:Disease Models, Animal; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D000077146:Irinotecan; D007583:Jejunum / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D052016:Mucositis / Q000139:chemically induced / Q000178:diet therapy* / Q000473:pathology; D018384:Oxidative Stress; D019936:Probiotics / Q000627:therapeutic use*; D012441:Saccharomyces cerevisiae; D015431:Weight Loss
chemical_list: D000077146:Irinotecan; D002166:Camptothecin
keywords: Saccharomyces cerevisiae UFMG A-905; chemotherapy, mucositis; oxidative stress; probiotic