title: Ovarian Hyperstimulation and Oocyte Harvesting Prior to Systemic Chemotherapy-A Possible Pitfall in 18F-FDG PET/CT Staging of Oncologic Patients.
abstract: A 33-year-old woman with Hodgkin disease Ann Arbor stage IIA underwent baseline F-FDG PET/CT scanning. The scan showed gross multicystic enlargement of both ovaries and a nodule at the edge of the right ovary with intense FDG uptake (SUVmax = 14.8). Differential diagnosis would include ovarian lymphoma manifestation, endometrioma, and ovarian or pelvic neoplasia. However, chart analysis revealed previous superstimulation with gonadotropins and gonadotropin release hormone antagonist, and transvaginal oocyte retrieval the day before FDG PET/CT. This led to the diagnosis of ovarian hyperstimulation syndrome, with the FDG-avid focus representing a hemorrhagic follicle after transvaginal oocyte retrieval procedure.
authors.affiliation: From the *Department of Nuclear Medicine, †Division of Reproductive Endocrinology, Department of Gynecology and Obstetrics, and ‡Department of Oncology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Sara
authors.initials: S
authors.lastname: Bacanovic
authors.forename: Ruth
authors.initials: R
authors.lastname: Stiller
authors.forename: Magdalena
authors.initials: M
authors.lastname: Pircher
authors.forename: Irene A
authors.initials: IA
authors.lastname: Burger
authors.forename: Martin W
authors.initials: MW
authors.lastname: Huellner
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D054315:Oocyte Retrieval / Q000009:adverse effects*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging*; D010062:Ovulation Induction / Q000009:adverse effects*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18