title: Novel immunotherapies for the treatment of melanoma.
abstract: Immunotherapies are achieving clinical success for the treatment of many cancers. However, it has taken a long time to exploit the potential of the immune system for the treatment of human cancers. We cannot forget that this has been the consequence of very extensive work in basic research in preclinical models and in human patients. Thus, it is rather hard to compile all of it while giving a comprehensive view on this subject. Here we have attempted to give an overall perspective in immunotherapy of melanoma. A brief overview on current therapies is provided, followed by adoptive cell therapies. Gene engineering strategies to improve these therapies are also explained, finishing with therapies based on interference with immune checkpoint pathways.
authors.affiliation: Immunomodulation Group, Navarrabiomed-Biomedical Research Centre, IdisNA. Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Gato-Cañas
authors.affiliation: Immunomodulation Group, Navarrabiomed-Biomedical Research Centre, IdisNA. Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
authors.forename: Hugo
authors.initials: H
authors.lastname: Arasanz
authors.affiliation: Immunomodulation Group, Navarrabiomed-Biomedical Research Centre, IdisNA. Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
authors.forename: Idoia
authors.initials: I
authors.lastname: Blanco-Luquin
authors.affiliation: Immunomodulation Group, Navarrabiomed-Biomedical Research Centre, IdisNA. Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
authors.forename: Estíbaliz
authors.initials: E
authors.lastname: Glaría
authors.affiliation: Immunomodulation Group, Navarrabiomed-Biomedical Research Centre, IdisNA. Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Arteta-Sanchez
authors.affiliation: Immunomodulation Group, Navarrabiomed-Biomedical Research Centre, IdisNA. Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Kochan
authors.affiliation: Immunomodulation Group, Navarrabiomed-Biomedical Research Centre, IdisNA. Irunlarrea 3, 31008, Pamplona, Navarra, Spain.|Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UK.
authors.forename: David
authors.initials: D
authors.lastname: Escors
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005818:Genetic Engineering; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D016219:Immunotherapy, Adoptive; D008213:Lymphocyte Activation; D008545:Melanoma / Q000276:immunology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D015398:Signal Transduction
keywords: adoptive transfer; cancer immunotherapy; melanoma