title: KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients.
abstract: We have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2(+) NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2(-) NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2(+) NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis.
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Italy. Electronic address: rbr@unife.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rizzo
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Italy.
authors.forename: Daria
authors.initials: D
authors.lastname: Bortolotti
authors.affiliation: Neuroradiology Unit, Department of Neurosciences and Rehabilitation, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, Ferrara, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Fainardi
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Gentili
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bolzani
authors.affiliation: Neurology Unit, Department of Neurosciences and Rehabilitation, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, Ferrara, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Baldi
authors.affiliation: Section of Neurology, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Casetta
authors.affiliation: Section of Neurology, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Granieri
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Rotola
authors.affiliation: INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Furlan
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Di Luca
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006561:Herpes Simplex; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism* / Q000821:virology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology* / Q000821:virology; D012333:RNA, Messenger / Q000378:metabolism; D054343:Receptors, KIR2DL2 / Q000235:genetics / Q000378:metabolism*; D058504:Th17 Cells / Q000378:metabolism; D019562:Viral Load / Q000379:methods
chemical_list: D016207:Cytokines; C515077:KIR2DL2 protein, human; D012333:RNA, Messenger; D054343:Receptors, KIR2DL2
keywords: Herpesvirus; Host/pathogens interactions; Inhibitory receptor; NK cells; Th17