title: A pure primary transitional cell carcinoma of the ovary: A rare case report with literature review.
abstract: Primary transitional cell carcinoma (TCC) of the ovary is a rare and recently recognized subtype of ovarian surface epithelial-stromal cancer. Pure forms of the TCC ovary account for only 1% of surface epithelial carcinomas. The clinical presentation is indistinguishable from other types of ovarian cancers. They have a favorable response to chemotherapy than other surface epithelial cancers. We report a case of 55-year-old woman who presented with a hard mass in the abdomen. Computed tomography-diagnosed it as a carcinoma of the ovary. Tumor was immunoreactive with Wilms' tumor protein-1 and nonreactive with cytokeratin 7 (CK7) and CK20. Histopathology diagnosis of primary TCC of the ovary was made. These tumors are needed to be differentiated from metastatic TCC from other sites and undifferentiated carcinomas of ovaries. Clinical features and immunohistochemistry are helpful. Surgical resection is the primary therapeutic approach followed by standardized chemotherapy.
authors.affiliation: Department of Pathology, Padm Dr. D. Y. Patil Medical College, Pimpri, Pune, Maharashtra, India.
authors.forename: Shirish S
authors.initials: SS
authors.lastname: Chandanwale
authors.affiliation: Department of Pathology, Padm Dr. D. Y. Patil Medical College, Pimpri, Pune, Maharashtra, India.
authors.forename: Tushar
authors.initials: T
authors.lastname: Kamble
authors.affiliation: Department of Pathology, Padm Dr. D. Y. Patil Medical College, Pimpri, Pune, Maharashtra, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Mishra
authors.affiliation: Department of Pathology, Padm Dr. D. Y. Patil Medical College, Pimpri, Pune, Maharashtra, India.
authors.forename: Harsh
authors.initials: H
authors.lastname: Kumar
authors.affiliation: Department of Pathology, Padm Dr. D. Y. Patil Medical College, Pimpri, Pune, Maharashtra, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Jadhav
keywords: Cytokeratin 20; Wilms’ tumor protein-1; cytokeratin 7; ovary; transitional cell carcinoma