title: RNA systems biology: uniting functional discoveries and structural tools to understand global roles of RNAs.
abstract: RNAs assume sophisticated structures that are active in myriad cellular processes. In this review, we highlight newly identified ribozymes, riboswitches, and small RNAs, some of which control the function of cellular metabolic and gene expression networks. We then examine recent developments in genome-wide RNA structure probing technologies that are yielding new insights into the structural landscape of the transcriptome. Finally, we discuss how these RNA 'structomic' methods can address emerging questions in RNA systems biology, from the mechanisms behind long non-coding RNAs to new bases for human diseases.
authors.affiliation: School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, United States.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Strobel
authors.affiliation: School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, United States.
authors.forename: Kyle E
authors.initials: KE
authors.lastname: Watters
authors.affiliation: School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, United States.
authors.forename: David
authors.initials: D
authors.lastname: Loughrey
authors.affiliation: School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, United States. Electronic address: jblucks@cornell.edu.
authors.forename: Julius B
authors.initials: JB
authors.lastname: Lucks
mesh_terms: D000818:Animals; D053263:Gene Regulatory Networks; D016678:Genome; D006801:Humans; D012313:RNA / Q000737:chemistry* / Q000235:genetics*; D049490:Systems Biology / Q000379:methods*; D059467:Transcriptome / Q000235:genetics*
chemical_list: D012313:RNA