title: State-of-the-Art Imaging and Staging of Plasma Cell Dyscrasias.
abstract: Monoclonal gammopathy of unknown significance (MGUS) is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder. Smoldering multiple myeloma, also called asymptomatic multiple myeloma, is an intermediate stage between MGUS and symptomatic multiple myeloma. As the name implies, extraosseous or extramedullary myeloma refers to the presence of myeloma deposits outside the skeletal system. Waldenström macroglobulinemia is a distinct subtype of plasma cell dyscrasia characterized by lymphoplasmacytic lymphoma in the bone marrow with an associated IgM monoclonal gammopathy. Amyloidosis is a condition characterized by extracellular deposition of fibrils composed of a variety of normal serum proteins.
authors.affiliation: Musculoskeletal Imaging, Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Behrang
authors.initials: B
authors.lastname: Amini
authors.affiliation: Hematology & Oncology, Medicine, Michael E DeBakey VA Medical Center, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Sarvari
authors.initials: S
authors.lastname: Yellapragada
authors.affiliation: Diagnostic Radiology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Shetal
authors.initials: S
authors.lastname: Shah
authors.affiliation: Nuclear Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Rohren
authors.affiliation: Abdominal Imaging, Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address: rvikram@mdanderson.org.
authors.forename: Raghunandan
authors.initials: R
authors.lastname: Vikram
mesh_terms: D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009367:Neoplasm Staging; D010265:Paraproteinemias / Q000000981:diagnostic imaging* / Q000473:pathology*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*
keywords: Imaging; Monoclonal gammopathy of unknown clinical significance; Multiple myeloma; Plasma cell dyscrasias; Smoldering myeloma; Solitary plasmacytoma