title: TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia.
abstract: An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenitor cell survival.
authors.affiliation: Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London and Barts Health, London, E12AT, UK.
authors.forename: Hemanth
authors.initials: H
authors.lastname: Tummala
authors.affiliation: Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London and Barts Health, London, E12AT, UK. Electronic address: i.dokal@qmul.ac.uk.
authors.forename: Inderjeet
authors.initials: I
authors.lastname: Dokal
mesh_terms: D000818:Animals; D004260:DNA Repair; D005199:Fanconi Anemia / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta