title: The comparison of chemerin, adiponectin and lipid profile indices in obese and non-obese adolescents.
abstract: OBJECTIVE
  The growing prevalence of obesity and its related metabolic disorders in adolescents shows the necessity of urgent focus on the related factors. Adipocytes secretions and their pro- or anti-inflammatory roles play effective roles in adipocytes metabolism. We assessed the relation between adiponectin, chemerin and lipid profile in hit phase of life.
  
  
  METHODS
  This case-control study conducted on 78 adolescent girls, divided based on BMI percentile. Serum chemerin, adiponectin, lipid profile and body fat mass were measured. Data were analyzed using Pearson correlation test. The interactive relation between these variables was assessed using Structural Equation Modeling (SEM). Data were analyzed using SPSS software and AMOS software.
  
  
  RESULTS
  Chemerin were correlated significantly with triglyceride (r=0.584 versus r=0.319), HDL-cholestrol (r=-0.323 versus r=-0.335), LDL-cholestrol (r=0.368 versus r=0.327) and fat mass (r=0.372 versus r=0.357) in obese versus non-obese girls; while the mentioned correlation were non-significant with total cholesterol in obese group (r=0.233 versus r=0.336). Furthermore, there were significant association between adiponectin and triglyceride (r=-0.404 versus r=-0.317), HDL-cholesterol (r=0.332 versus r=0.316) and fat mass (r=-0.529 versus r=-0.346) in obese versus non-obese girls, respectively.
  
  
  CONCLUSIONS
  There were positive associations between lipid profile components and serum chemerin levels. Adiponectin levels were in positive correlation with HDL-cholesterol concentrations. Chemerin showed positive correlations with potent health threatening components of lipid profile including triglyceride and cholesterol levels in adolescents.
authors.affiliation: Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics and Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: z_maghsoudi@hlth.mui.ac.ir.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Maghsoudi
authors.affiliation: Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
authors.affiliation: Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics and Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Hosseinzadeh-Attar
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007492:Iran; D008055:Lipids / Q000097:blood*; D009765:Obesity / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; C478630:RARRES2 protein, human
keywords: Adiponectin; Adolescents; Chemerin; Lipid profile