title: Comparison of multislice breath-hold and 3D respiratory triggered T1 ρ imaging of liver in healthy volunteers and liver cirrhosis patients in 3.0 T MRI.
abstract: To compare visual quality and quantitative measurements of multislice (MS) breath-hold and 3D respiratory-triggered T1 ρ sequences.
  
  
  
  T1 ρ scans including MS BLOCK T1 ρ, MS HS8 T1 ρ, and 3D BLOCK T1 ρ were performed on 40 healthy volunteers and 17 liver cirrhosis patients on 3.0T magnetic resonance imaging (MRI). The MS breath-hold methods scanned three slices while the 3D method covered 26 slices. Visual scores of image quality, T1 ρ measurements of the three sequences, and T1 ρ values of healthy volunteers and cirrhosis patients were compared using parametric tests.
  
  
  
  Average visual scores for volunteers and patients of the three sequences were 3.19 and 2.82 for MS BLOCK T1 ρ; 3.71 and 3.59 for MS HS8 T1 ρ; 3.29 and 3.59 for 3D BLOCK T1 ρ, respectively. Difference of visual scores among the three groups was significant (P < 0.001). Differences in T1 ρ values among the three methods were significant (P < 0.001). Difference of T1 ρ between MS BLOCK T1 ρ and 3D BLOCK T1 ρ was not significant (volunteer: P = 0.82, patient: 0.92) while the difference of T1 ρ between MS BLOCK T1 ρ and MS HS8 T1 ρ, MS HS8 T1 ρ and 3D BLOCK T1 ρ was significant in both volunteers and patients (P < 0.01). Differences of T1 ρ between healthy volunteers and patients were all significant in three T1 ρ sequences (P = 0.04, 0.004, 0.03).
  
  
  
  Of the tested sequences, the image quality of MS HS8 T1 ρ was best, but 3D BLOCK T1 ρ with respiratory triggering should also be considered as an alternative sequence for clinical diagnosis of liver cirrhosis due to its superior coverage. J. MAGN. RESON. IMAGING 2016;44:906-913.
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China.
authors.forename: Qihua
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China.
authors.forename: Taihui
authors.initials: T
authors.lastname: Yu
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China.
authors.forename: Su
authors.initials: S
authors.lastname: Yun
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China.
authors.forename: Ziliang
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China.
authors.forename: Jinglian
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Huang
authors.affiliation: Philips Healthcare, Tokyo, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Okuaki
authors.affiliation: Philips Healthcare, Hong Kong.
authors.forename: Queenie
authors.initials: Q
authors.lastname: Chan
authors.affiliation: Sun Yat-Sen Memorial Hospital, Guang Zhou, Guang Dong, China. liangbl@163.net.
authors.forename: Biling
authors.initials: B
authors.lastname: Liang
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China. huaguo@tsinghua.edu.cn.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
mesh_terms: D000328:Adult; D016477:Artifacts; D062485:Breath Holding; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009038:Motion; D012016:Reference Values; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
keywords: T1ρ imaging; T1ρ mapping; liver cirrhosis; liver imaging