title: [Role of GAGA Factor in Drosophila Primordial Germ Cell Migration and Gonad Development].
abstract: The GAGA protein of drosophila is a factor involved in epigenetic transcription regulation of a large gene group controlling developmental processes. In this paper, the role of GAGA factor in germ cell migration is demonstrated as well as its effect on the gonad development in drosophila embryogenesis. Mutations in the Trl gene, encoding GAGA factor, prematurely induces the active migration program and relocation of the primordial cells inward the embryo before the beginning of gastrulation. The germ cells that prematurely separated from the main group migrate ectopically, lose orientation, and stay out of gonad development. Expression pattern of the Trl gene suggests its activity in epithelial cells of the embryonic blastoderm, part of which contact primordial cells. Thus, GAGA factor influences migration of these cells in an indirect manner via their somatic environment.
authors.forename: N V
authors.initials: NV
authors.lastname: Dorogova
authors.forename: A S
authors.initials: AS
authors.lastname: Khrushcheva
authors.forename: E V
authors.initials: EV
authors.lastname: Fedorova
authors.forename: A A
authors.initials: AA
authors.lastname: Ogienko
authors.forename: E M
authors.initials: EM
authors.lastname: Baricheva
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000196:embryology*; D005854:Germ Cells / Q000166:cytology / Q000378:metabolism*; D006066:Gonads / Q000166:cytology / Q000196:embryology*; D006801:Humans; D008297:Male; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D014157:Transcription Factors; C063460:Trl protein, Drosophila