title: [The level of circulating PGC1a in cardiovascular disease].
abstract: The level of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC1α) in human blood plasma was investigated. Samples of healthy individuals (n=34) and patients with cardiovascular diseases (n=110), including aortic aneurysm (n=69), aortic stenosis (n=25) and patients without aortic pathologies were analyzed. In patients the PGC1α concentration was higher than that in healthy persons, and tended to decrease with age. Elevated concentrations of lactic acid, total homocysteine and asymmetric dimethylarginine in the blood of patients suggested a parallel development of endothelial and secondary mitochondrial dysfunction. However, concentrations of lactic and pyruvic acids exceeding reference limit were associated with the decrease in the PGC1α level.
authors.affiliation: Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia; Federal Almazov Medical Research Center, Saint Petersburg, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Zhloba
authors.affiliation: Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia; Federal Almazov Medical Research Center, Saint Petersburg, Russia.
authors.forename: T F
authors.initials: TF
authors.lastname: Subbotina
authors.affiliation: Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia; Federal Almazov Medical Research Center, Saint Petersburg, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Alekseevskaya
authors.affiliation: Federal Almazov Medical Research Center, Saint Petersburg, Russia.
authors.forename: O M
authors.initials: OM
authors.lastname: Moiseeva
authors.affiliation: Federal Almazov Medical Research Center, Saint Petersburg, Russia.
authors.forename: N D
authors.initials: ND
authors.lastname: Gavrilyuk
authors.affiliation: Federal Almazov Medical Research Center, Saint Petersburg, Russia.
authors.forename: O B
authors.initials: OB
authors.lastname: Irtyuga
mesh_terms: D000367:Age Factors; D001014:Aortic Aneurysm / Q000097:blood; D001024:Aortic Valve Stenosis / Q000097:blood; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood*; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D009589:Nitrogen Oxides / Q000097:blood; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D019289:Pyruvic Acid / Q000097:blood; D014157:Transcription Factors / Q000097:blood*
chemical_list: D015415:Biomarkers; D009589:Nitrogen Oxides; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors; C487735:dimethylarginine; D006710:Homocysteine; D019344:Lactic Acid; D019289:Pyruvic Acid; D001120:Arginine
keywords: PGC1a; blood plasma; diagnostics of mitochondrial dysfunction; endothelial dysfunction; lactic acid; pyruvic acid