title: Early detection of emerging street drugs by near infrared spectroscopy and chemometrics.
abstract: Near-infrared spectroscopy (NIRs) is spreading as the tool of choice for fast and non-destructive analysis and detection of different compounds in complex matrices. This paper investigated the feasibility of using near infrared (NIR) spectroscopy coupled to chemometrics calibration to detect new psychoactive substances in street samples. The capabilities of this approach in forensic chemistry were assessed in the determination of new molecules appeared in the illicit market and often claimed to contain "non-illegal" compounds, although exhibiting important psychoactive effects. The study focused on synthetic molecules belonging to the classes of synthetic cannabinoids and phenethylamines. The approach was validated comparing results with officials methods and has been successfully applied for "in site" determination of illicit drugs in confiscated real samples, in cooperation with the Scientific Investigation Department (Carabinieri-RIS) of Rome. The achieved results allow to consider NIR spectroscopy analysis followed by chemometrics as a fast, cost-effective and useful tool for the preliminary determination of new psychoactive substances in forensic science.
authors.affiliation: Department of Chemistry - "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy. Electronic address: roberta.risoluti@uniroma1.it.
authors.forename: R
authors.initials: R
authors.lastname: Risoluti
authors.affiliation: Department of Chemistry - "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Materazzi
authors.affiliation: Carabinieri RIS, Scientific Investigation Department, v.le Tor di Quinto, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gregori
authors.affiliation: Carabinieri RIS, Scientific Investigation Department, v.le Tor di Quinto, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ripani
mesh_terms: D002186:Cannabinoids; D002853:Chromatography, Liquid; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis*; D011619:Psychotropic Drugs; D019265:Spectroscopy, Near-Infrared
chemical_list: D002186:Cannabinoids; D013287:Illicit Drugs; D011619:Psychotropic Drugs
keywords: Forensic science; JWH, AKB48; NBOMe; NIR; New drugs