title: Epigenetic changes of CDX2 in gastric adenocarcinoma.
abstract: Gastric cancer is one of the most commonplace and lethal cancers in the world. Molecular investigation of this disease, in order to obtain diagnostic and treatments achievements is important and vital. Relatively, in this research study, one of the most important epigenetic factors, the methylation of CDX2 gene was investigated in tumoral and non-tumoral tissues of gastric cancer patients by bisulfite treatment followed by sequencing of the 5'UTR region of CDX2 in both tissues. The results indicated a hypomethylation in tumoral tissues of adenocarcinoma. Consequently, the methylation amount of CDX2 in tumoral tissues was significantly reduced compared with non-tumoral tissues.
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Samadani
authors.affiliation: Department of Surgery, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Novin
authors.initials: N
authors.lastname: Nikbakhsh
authors.affiliation: Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Pilehchian
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Sadegh
authors.initials: S
authors.lastname: Fattahi
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran. halehakhavan@yahoo.com.|Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran. halehakhavan@yahoo.com.
authors.forename: Haleh
authors.initials: H
authors.lastname: Akhavan-Niaki
keywords: CDX2; Gastric cancer; Methylation; UTR