title: Symptomatic Radiation Pneumonitis After Accelerated Partial Breast Irradiation Using Three-dimensional Conformal Radiotherapy.
abstract: OBJECTIVE
  To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT).
  
  
  METHODS
  The prescribed radiation dose was 30 Gy in 5 fractions over 10 days. Toxicity was graded according to the Common Terminology Criteria for Adverse Events (version 4.0).
  
  
  RESULTS
  Fifty-five patients were enrolled from August 2010 to October 2013 and the median follow-up time was 30 months (range=18-46 months). Three patients (5%) developed grade 2 symptomatic radiation pneumonitis after 3D-CRT APBI. Among 16 patients with ILV10Gy (% ipsilateral lung receiving ≥10 Gy) of 10% or higher, three patients (19%) developed symptomatic radiation pneumonitis. This trend was not observed in any of the patients with ILV10Gy less than 10% (p=0.005).
  
  
  CONCLUSIONS
  High ILV10Gy might be associated with symptomatic radiation pneumonitis after 3D-CRT APBI.
authors.affiliation: Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan nshikama0525@gmail.com.
authors.forename: Naoto
authors.initials: N
authors.lastname: Shikama
authors.affiliation: Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Y U
authors.initials: YU
authors.lastname: Kumazaki
authors.affiliation: Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Miyazawa
authors.affiliation: Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyaura
authors.affiliation: Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kato
authors.affiliation: Department of Radiation Oncology, National Cancer Center East, Chiba, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: Department of Radiation Oncology, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Kawamori
authors.affiliation: Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Shimizuguchi
authors.affiliation: Department of Radiology, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Saito
authors.affiliation: Department of Breast Oncology Service, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Saeki
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017564:Radiation Pneumonitis / Q000209:etiology*; D020266:Radiotherapy, Conformal / Q000009:adverse effects* / Q000379:methods
keywords: Partial breast irradiation; adverse event; breast cancer; symptomatic pneumonitis; three-dimensional conformal radiotherapy