title: Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls.
abstract: Childhood trauma (CT) is a major risk factor for psychiatric conditions. It is hypothesized that CT effects are mediated by the limbic system. Few multimodal neuroimaging studies allow an integrated perspective of this impact. Our goal was thus to study the effects of CT on the limbic network.
  
  
  
  We acquired multimodal MRI (T1, diffusion weighted, and resting state fMRI) data from 79 subjects (47 healthy controls and 32 patients with bipolar disorder, BD). We performed correlational analyses between Childhood Trauma Questionnaire (sub)scores (physical and emotional abuse/neglect and sexual abuse) and anatomo-functional measurements of the limbic network (hippocampal and amygdala volumes, prefronto-limbic functional connectivity, uncinate fractional anisotropy).
  
  
  
  We found CTQ total scores to be negatively correlated with amygdala volume, prefronto-limbic functional connectivity (FC) and uncinate fractional anisotropy in our sample. Considering subscores, neglects (physical and emotional) were the only to affect neural parameters. The patients with BD drove most of the results.
  
  
  
  Small sample size and low level of trauma in controls.
  
  
  
  Our multimodal approach enabled an integrated view of the long-term effects of CT on the limbic system.
authors.affiliation: CAPES Foundation, Ministry of Education of Brazil, Brasília/DF 70040-020, Brazil; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Souza-Queiroz
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France; Neurospin, UNIACT Lab, Psychiatry Team, CEA Saclay, Gif sur Yvette, France.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Boisgontier
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Etain
authors.affiliation: Neurospin, UNIRS Lab, CEA Saclay, Gif Sur Yvette, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Poupon
authors.affiliation: Neurospin, UNIRS Lab, CEA Saclay, Gif Sur Yvette, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Duclap
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France; Neurospin, UNIACT Lab, Psychiatry Team, CEA Saclay, Gif sur Yvette, France.
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: d'Albis
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Daban
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France.
authors.forename: Nora
authors.initials: N
authors.lastname: Hamdani
authors.affiliation: AP-HP, Centre d'Investigation Clinique, Hôpitaux Henri Mondor, Créteil, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Le Corvoisier
authors.affiliation: Fondation FondaMental, Créteil, France; Inserm, Université Paris Diderot, UMR-S 1144, Paris, France; AP-HP, GH Saint-Louis - Lariboisière - Fernand Widal, Pôle Neurosciences, Paris, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Delavest
authors.affiliation: Fondation FondaMental, Créteil, France; Inserm, Université Paris Diderot, UMR-S 1144, Paris, France; AP-HP, GH Saint-Louis - Lariboisière - Fernand Widal, Pôle Neurosciences, Paris, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier
authors.affiliation: Faculty of Engineering, University of Concepción, Concepción, Chile.
authors.forename: Pamela
authors.initials: P
authors.lastname: Guevara
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France; Institut Pasteur, Unité Perception et Mémoire, F-75015 Paris, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Henry
authors.affiliation: AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France; Neurospin, UNIACT Lab, Psychiatry Team, CEA Saclay, Gif sur Yvette, France. Electronic address: josselin.houenou@inserm.fr.
authors.forename: Josselin
authors.initials: J
authors.lastname: Houenou
mesh_terms: D000328:Adult; D054523:Adult Survivors of Child Abuse / Q000523:psychology*; D000679:Amygdala / Q000000981:diagnostic imaging*; D001714:Bipolar Disorder / Q000000981:diagnostic imaging* / Q000523:psychology; D004644:Emotions; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging*; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009929:Organ Size / Q000502:physiology; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Connectivity; FMRI; Limbic System; MRI; Tractography; Trauma