title: Effects of Lactobacillus plantarum TWK10-Fermented Soymilk on Deoxycorticosterone Acetate-Salt-Induced Hypertension and Associated Dementia in Rats.
abstract: Oxidative stress resulting from excessive production of reactive oxygen species is the major mediator of neuronal cell degeneration observed in neurodegenerative diseases, such as Alzheimer's disease (AD) and vascular dementia (VaD). Additionally, hypertension has been shown to be a positive risk factor for VaD. Therefore, the objective of this study was to investigate the effects of Lactobacillus plantarum strain TWK10 (TWK10)-fermented soymilk on the protection of PC-12 cells in H₂O₂-, oxygen-glucose deprivation (OGD)- and deoxycorticosterone acetate (DOCA)-salt-induced rat models of VaD. Notably, the viabilities of H₂O₂-treated PC-12 cells and OGD model were significantly increased by treatment with TWK10-fermented soymilk ethanol extract (p < 0.05). In addition, oral administration of TWK10-fermented soymilk extract in DOCA-salt hypertension-induced VaD rats resulted in a significant decrease in blood pressure (p < 0.05), which was regulated by inhibiting ACE activity and promoting NO production, in addition to decreased escape latency and increased target crossing (p < 0.05). In conclusion, these results demonstrated that TWK10-fermented soymilk extract could improve learning and memory in DOCA-salt hypertension-induced VaD rats by acting as a blood pressure-lowering and neuroprotective agent.
authors.affiliation: Department of Food Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan. r19901217@hotmail.com.
authors.forename: Te-Hua
authors.initials: TH
authors.lastname: Liu
authors.affiliation: Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518000, China. jiachi.amber.chiou@polyu.edu.hk.
authors.forename: Jiachi
authors.initials: J
authors.lastname: Chiou
authors.affiliation: Department of Food Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan. tytsai@mail.fju.edu.tw.
authors.forename: Tsung-Yu
authors.initials: TY
authors.lastname: Tsai
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003704:Dementia; D003900:Desoxycorticosterone / Q000633:toxicity*; D005285:Fermentation; D006973:Hypertension / Q000209:etiology* / Q000517:prevention & control*; D048191:Lactiplantibacillus plantarum / Q000737:chemistry*; D007858:Learning / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D017673:Sodium Chloride, Dietary / Q000633:toxicity*; D041942:Soy Milk / Q000737:chemistry / Q000494:pharmacology*; D013550:Swimming
chemical_list: D017382:Reactive Oxygen Species; D017673:Sodium Chloride, Dietary; D003900:Desoxycorticosterone
keywords: dementia; fermented soymilk; hypertension; neuronal cell degeneration; reactive oxygen species