title: A New Fluorinated Tyrosinase Inhibitor from a Chemically Engineered Essential Oil.
abstract: The generation of fluorinated essential oils as a source of bioactive compounds is described. Most of the components of the natural mixtures were altered, leading to the discovery of a new fluorinated tyrosinase inhibitor.
authors.affiliation: Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, CONICET-UNR), Ocampo y Esmeralda, 2000, Rosario, Argentina.
authors.forename: Paula
authors.initials: P
authors.lastname: García
authors.affiliation: Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , 2000, Suipacha 531, Rosario, Argentina.|Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, CONICET-UNR), Ocampo y Esmeralda, 2000, Rosario, Argentina.
authors.forename: Mario O
authors.initials: MO
authors.lastname: Salazar
authors.affiliation: Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, CONICET-UNR), Ocampo y Esmeralda, 2000, Rosario, Argentina.
authors.forename: I Ayelen
authors.initials: IA
authors.lastname: Ramallo
authors.affiliation: Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , 2000, Suipacha 531, Rosario, Argentina.|Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, CONICET-UNR), Ocampo y Esmeralda, 2000, Rosario, Argentina.
authors.forename: Ricardo L E
authors.initials: RL
authors.lastname: Furlan
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D054879:Halogenation; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D009822:Oils, Volatile / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D009822:Oils, Volatile; D014442:Monophenol Monooxygenase
keywords: bioactive compound; diversification; essential oil; fluorination; tyrosinase