title: PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.
abstract: Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.
authors.affiliation: DIBINEM, University of Bologna, via Irnerio n 4840126, Bologna, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Fiume
authors.affiliation: AstraZeneca, Oncology iMED, Mereside, Alderley Park, Macclesfield, SK10 4TG, UK.
authors.forename: David R
authors.initials: DR
authors.lastname: Jones
authors.affiliation: The Inositide Laboratory, Centre for Biological Sciences, Highfield Campus, Southampton University, Southampton, SO17 1BJ, UK; INGM Istituto Nazionale Genetica Molecolare, Padiglione Romeo ed Enrica Invernizzi, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza, 35 - 20122 Milano, Italy, C.F. / P.IVA 04175700964. 3. Electronic address: n.divecha@soton.ac.uk.
authors.forename: Nullin
authors.initials: N
authors.lastname: Divecha
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D002461:Cell Line, Transformed; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008819:Mice, Nude; D009154:Mutation; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics* / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D007527:Isoenzymes; D018129:Phosphatidylinositol Phosphates; C113567:phosphatidylinositol 5-phosphate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase