title: CONCENTRATIONS OF VITREAL CYTOKINES IN RHEGMATOGENOUS RETINAL DETACHMENT.
abstract: Proliferative vitreoretinopathy (PVR) is one of the most frequent causes of failure of rhegmatogenous retinal detachment (RRD) surgery.
  
  
  OBJECTIVE
  To measure the vitreous levels of granulocyte colony stimulating factor (G-CSF) and monocyte chemoattractant protein 1 (MCP-1) in eyes with RRD and in a control group.
  
  
  METHODS
  A prospective study of 40 patients operated for RRD (study group) and 20 patients with epiretinal membrane or macular holes (selected as control group since they needed vitrectomy but had attached retinas). Vitreous samples were collected during vitrectomy and were assessed for the presence of cytokines using a fluorescent bead-based multiplex assay.
  
  
  RESULTS
  The concentration of G-CSF (8.59 pg/ml) and MCP-1 (1615.2 pg/ml) were significantly increased in the study group, when compared to the control group (0 and 469.13 pg/ml, respectively). MCP-1 was also significantly increased in the subgroup of patients with PVR compared to the patients with uncomplicated RRD.
  
  
  CONCLUSIONS
  The levels of these biomarkers support the idea that proliferative vitreoretinopathy has an inflammatory component.
authors.forename: C
authors.initials: C
authors.lastname: Danielescu
authors.forename: F
authors.initials: F
authors.lastname: Zugun-Eloae
authors.forename: Mihaela
authors.initials: M
authors.lastname: Zlei
mesh_terms: D015415:Biomarkers; D018932:Chemokine CCL2 / Q000096:biosynthesis; D018925:Chemokines / Q000096:biosynthesis*; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis; D012163:Retinal Detachment / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012680:Sensitivity and Specificity; D014821:Vitrectomy / Q000009:adverse effects; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018932:Chemokine CCL2; D018925:Chemokines; D016207:Cytokines; D016188:Receptors, Granulocyte Colony-Stimulating Factor