title: Feasibility and effectiveness of a cognitive remediation programme with original computerised cognitive training and group intervention for schizophrenia: a multicentre randomised trial.
abstract: Devising new methods to improve neurocognitive impairment through cognitive remediation is an important research goal. We developed an original computer programme termed the Japanese Cognitive Rehabilitation Programme for Schizophrenia (JCORES) that provides cognitive practice across a broad range of abilities. The current study examined for the first time whether a cognitive remediation programme, including both computerised cognitive training using JCORES and group intervention such as enhancing meta-cognition and teaching strategies, is more effective than treatment as usual for improving neurocognitive and social functioning. Sixty-two outpatients with schizophrenia were randomised to either a cognitive remediation group or a control group. Participants engaged in two computerised cognitive training sessions and one group meeting per week for 12 weeks. The average number of total sessions attended (computerised cognitive practice + group intervention) was 32.3 (89.7%). The cognitive remediation group showed significantly more improvements in verbal memory, composite score of the Brief Assessment of Cognition in Schizophrenia, Japanese version (BACS-J), and general psychopathology on the Positive and Negative Syndrome Scale (PANSS) than the control group. These findings demonstrate that a cognitive remediation programme is feasible in Japan and is a more effective way to improve neurocognitive functioning and psychiatric symptoms.
authors.affiliation: a Department of Psychiatry , Nara Medical University School of Medicine , Nara , Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: a Department of Psychiatry , Nara Medical University School of Medicine , Nara , Japan.
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Morimoto
authors.affiliation: b Department of Psychiatry , Tokyo Metropolitan Police Hospital , Tokyo , Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Furukawa
authors.affiliation: c Department of Psychiatric Rehabilitation, National Center of Neurology and Psychiatry , National Institute of Mental Health , Tokyo , Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Sato
authors.affiliation: d Department of Psychiatry , Teikyo University School of Medicine , Tokyo , Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Hatsuse
authors.affiliation: e Center for Clinical Research and Development Initiative , Osaka Psychiatric Medical Center , Osaka , Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwata
authors.affiliation: f Department of Mental Health and Psychiatric Nursing , the University of Tokyo , Tokyo , Japan.
authors.forename: Mieko
authors.initials: M
authors.lastname: Kimura
authors.affiliation: a Department of Psychiatry , Nara Medical University School of Medicine , Nara , Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
authors.affiliation: d Department of Psychiatry , Teikyo University School of Medicine , Tokyo , Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Ikebuchi
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology / Q000534:rehabilitation*; D000072466:Cognitive Remediation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000534:rehabilitation; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications* / Q000534:rehabilitation; D012565:Schizophrenic Psychology; D013813:Therapy, Computer-Assisted / Q000379:methods*; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult
keywords: JCORES; Schizophrenia; cognitive remediation training; original computer software; randomised control trial