title: Mesenchymal stem cell subpopulations: phenotype, property and therapeutic potential.
abstract: Mesenchymal stem cells (MSC) are capable of differentiating into cells of multiple cell lineages and have potent paracrine effects. Due to their easy preparation and low immunogenicity, MSC have emerged as an extremely promising therapeutic agent in regenerative medicine for diverse diseases. However, MSC are heterogeneous with respect to phenotype and function in current isolation and cultivation regimes, which often lead to incomparable experimental results. In addition, there may be specific stem cell subpopulations with definite differentiation capacity toward certain lineages in addition to stem cells with multi-differentiation potential. Recent studies have identified several subsets of MSC which exhibit distinct features and biological activities, and enhanced therapeutic potentials for certain diseases. In this review, we give an overview of these subsets for their phenotypic, biological and functional properties.
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing, China.|The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, L406A, Tsinghua Campus, The University Town, Shenzhen, China.
authors.forename: Miaohua
authors.initials: M
authors.lastname: Mo
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing, China.|The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, L406A, Tsinghua Campus, The University Town, Shenzhen, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing, China.|The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, L406A, Tsinghua Campus, The University Town, Shenzhen, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Qingdao Municipal Hospital, 5 Donghai M Rd, Qingdao, China. qdlidaye@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, L406A, Tsinghua Campus, The University Town, Shenzhen, China. wu.yaojiong@sz.tsinghua.edu.cn.
authors.forename: Yaojiong
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism; D051929:CD146 Antigen / Q000378:metabolism; D002454:Cell Differentiation; D000071063:Endoglin / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D064231:Nestin / Q000378:metabolism; D010641:Phenotype; D019718:Receptors, CXCR4 / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism; D044968:Regenerative Medicine; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D000954:Antigens, Surface; D051929:CD146 Antigen; C527276:CXCR4 protein, human; C064206:ENG protein, human; D000071063:Endoglin; C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; D019718:Receptors, CXCR4; D017475:Receptors, Nerve Growth Factor; C525591:STRO-1 antigen, human; D019010:Vascular Cell Adhesion Molecule-1; D017479:Receptors, Platelet-Derived Growth Factor
keywords: CD146; Cell surface markers; Heterogeneity; PDGFR; Stromal cells