title: Maintenance of Epigenetic Information.
abstract: The genome is subject to a diverse array of epigenetic modifications from DNA methylation to histone posttranslational changes. Many of these marks are somatically stable through cell division. This article focuses on our knowledge of the mechanisms governing the inheritance of epigenetic marks, particularly, repressive ones, when the DNA and chromatin template are duplicated in S phase. This involves the action of histone chaperones, nucleosome-remodeling enzymes, histone and DNA methylation binding proteins, and chromatin-modifying enzymes. Last, the timing of DNA replication is discussed, including the question of whether this constitutes an epigenetic mark that facilitates the propagation of epigenetic marks.
authors.affiliation: Department of Nuclear Dynamics and Genome Plasticity, Institut Curie, Section de recherche, 75231 Paris Cedex 05, France.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Almouzni
authors.affiliation: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Ein Kerem, Jerusalem, Israel 91120.
authors.forename: Howard
authors.initials: H
authors.lastname: Cedar
mesh_terms: D019175:DNA Methylation; D004261:DNA Replication / Q000502:physiology; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D056488:Histone Chaperones / Q000502:physiology; D042421:Histone Code; D008957:Models, Genetic; D011499:Protein Processing, Post-Translational
chemical_list: D056488:Histone Chaperones