title: Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes: A review.
abstract: Micronutrients are gaining acceptance as an important nutritional therapy for the prevention and/or management of diabetes and its associated health risks. Although a very small quantity of micronutrients are required for specific functions in our bodies, moderate deficiencies can lead to serious health issues. Impaired insulin sensitivity and glucose intolerance play a major role in the development of diabetic pathophysiology. Vitamin K is well known for its function in blood coagulation. Moreover, several human studies reported the beneficial role of vitamin K supplementation in improving insulin sensitivity and glucose tolerance, preventing insulin resistance, and reducing the risk of type 2 diabetes (T2 D). Both animal and human studies have suggested that vitamin K-dependent protein (osteocalcin [OC]), regulation of adipokine levels, antiinflammatory properties, and lipid-lowering effects may mediate the beneficial function of vitamin K in insulin sensitivity and glucose tolerance. This review for the first time provides an overview of the currently available preclinical and clinical evidences on the effect of vitamin K supplementation in the management of insulin sensitivity and glucose tolerance. The outcome of this review will increase understanding for the development of a novel adjuvant therapy to achieve better control of glycemia and improve the lives of diabetic patients.
authors.affiliation: Biotechnology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, India. Electronic address: pmanna2012@gmail.com.
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Manna
authors.affiliation: Biotechnology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, India.
authors.forename: Jatin
authors.initials: J
authors.lastname: Kalita
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000517:prevention & control*; D019587:Dietary Supplements; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D040242:Risk Reduction Behavior; D014812:Vitamin K / Q000097:blood / Q000627:therapeutic use*; D014815:Vitamins / Q000097:blood / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014815:Vitamins; D014812:Vitamin K
keywords: Anti-inflammatory; Glucose tolerance; Insulin sensitivity; Lipid lowering; Reduced risk of T2 D; Vitamin K