title: Estimation of Fat-free Mass at Discharge in Preterm Infants Fed With Optimized Feeding Regimen.
abstract: The purpose of the present study was to validate a previously calculated equation (E1) that estimates infant fat-free mass (FFM) at discharge using data from a population of preterm infants receiving an optimized feeding regimen.
  
  
  
  Preterm infants born before 33 weeks of gestation between April 2014 and November 2015 in the tertiary care unit of Croix-Rousse Hospital in Lyon, France, were included in the study. At discharge, FFM was assessed by air displacement plethysmography (PEA POD) and was compared with FFM estimated by E1. FFM was estimated using a multiple linear regression model.
  
  
  
  Data on 155 preterm infants were collected. There was a strong correlation between the FFM estimated by E1 and FFM assessed by the PEA POD (r = 0.939). E1, however, underestimated the FFM (average difference: -197 g), and this underestimation increased as FFM increased. A new, more predictive equation is proposed (r = 0.950, average difference: -12 g).
  
  
  
  Although previous estimation methods were useful for estimating FFM at discharge, an equation adapted to present populations of preterm infants with "modern" neonatal care and nutritional practices is required for accuracy.
authors.affiliation: *Neonatology, Croix Rousse Hospital †Centre for Clinical Research, University Hospital Croix Rousse, Hospices Civils de Lyon, Lyon ‡Lyon-Sud Charles Merieux Medical School, Claude Bernard University Lyon 1 §Rhone-Alpes Human Nutrition Research Center, Pierre Benite, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Larcade
authors.forename: Pierre
authors.initials: P
authors.lastname: Pradat
authors.forename: Rachel
authors.initials: R
authors.lastname: Buffin
authors.forename: Charline
authors.initials: C
authors.lastname: Leick-Courtois
authors.forename: Emilie
authors.initials: E
authors.lastname: Jourdes
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Picaud
mesh_terms: D000273:Adipose Tissue; D000886:Anthropometry / Q000379:methods; D001823:Body Composition; D001825:Body Fluid Compartments / Q000502:physiology*; D004032:Diet / Q000592:standards*; D005247:Feeding Behavior; D005260:Female; D005602:France; D005865:Gestational Age; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D016014:Linear Models; D008297:Male; D055641:Mathematical Concepts; D008954:Models, Biological; D010351:Patient Discharge; D010991:Plethysmography; D015203:Reproducibility of Results