title: Rab-mediated membrane trafficking and the control of epithelial cell polarity.
abstract: Development of cell polarity requires apical trafficking of podocalyxin; yet the regulation of its transport is unclear. In this issue, Mrozowska and Fukuda (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201512024) demonstrate that different sets of Rabs and Rab effectors are used to regulate podocalyxin trafficking in two- versus three-dimensional model systems.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Ioannou
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada peter.mcpherson@mcgill.ca.
authors.forename: Peter S
authors.initials: PS
authors.lastname: McPherson
mesh_terms: D016764:Cell Polarity; D004847:Epithelial Cells; D008566:Membranes; D021381:Protein Transport