title: solarius: an R interface to SOLAR for variance component analysis in pedigrees.
abstract: : The open source environment R is one of the most widely used software for statistical computing. It provides a variety of applications including statistical genetics. Most of the powerful tools for quantitative genetic analyses are stand-alone free programs developed by researchers in academia. SOLAR is one of the standard software programs to perform linkage and association mappings of the quantitative trait loci (QTLs) in pedigrees of arbitrary size and complexity. solarius allows the user to exploit the variance component methods implemented in SOLAR. It automates such routine operations as formatting pedigree and phenotype data. It parses also the model output and contains summary and plotting functions for exploration of the results. In addition, solarius enables parallel computing of the linkage and association analyses that makes the calculation of genome-wide scans more efficient.
  
  
  
  solarius is available on CRAN and on GitHub https://github.com/ugcd/solarius
  
  
  
  : aziyatdinov@santpau.cat.
authors.affiliation: Unitat De Genòmica De Malalties Complexes, Institut D'investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
authors.forename: Andrey
authors.initials: A
authors.lastname: Ziyatdinov
authors.affiliation: Unitat De Genòmica De Malalties Complexes, Institut D'investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
authors.forename: Helena
authors.initials: H
authors.lastname: Brunel
authors.affiliation: Unitat De Genòmica De Malalties Complexes, Institut D'investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Martinez-Perez
authors.affiliation: Department of Genetics Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Buil
authors.affiliation: B2SLab, Department ESAII, Universitat Politècnica De Catalunya, Barcelona, Spain CIBER in Bioengineering Biomaterials and Nanomedicine, Barcelona, Spain.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Perera
authors.affiliation: Unitat De Genòmica De Malalties Complexes, Institut D'investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Soria
mesh_terms: D000704:Analysis of Variance; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D015233:Models, Statistical; D015999:Multivariate Analysis; D010375:Pedigree; D040641:Quantitative Trait Loci; D012984:Software