title: Relationship between mitochondrial haplogroup and physiological responses to hypobaric hypoxia.
abstract: We aimed to investigate the relationship between mtDNA polymorphism and physiological responses to hypobaric hypoxia. The study included 28 healthy male students, consisting of 18 students in haplogroup D and 10 in haplogroup M7+G. Measurement sensors were attached to the participants for approximately 30 min in an environment with a temperature of 28 °C. After resting for 15 min, the programmed operation of the hypobaric chamber decreased the atmospheric pressure by 11.9 Torr every minute to simulate an increase in altitude of 150 m until 9.7 Torr (equivalent to 2500 m) and then decreased 9.7 Torr every minute until 465 Torr (equivalent to 4000 m). At each altitude, the pressure was maintained for 15 min and various measurements were taken. Haplogroup D showed higher SpO2 (p < 0.05) and significantly higher SpO2 during the pressure recovery period when compared with haplogroup M7+G. The distal skin temperature was higher in haplogroup D when compared with M7+G. These results suggested that haplogroup D maintained SpO2 at a higher level with higher peripheral blood flow during acute hypobaric exposure.
authors.affiliation: Faculty of Design, Kyushu University, 4-9-1 Shiobaru, Minamiku, Fukuoka, 815-8540, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Motoi
authors.affiliation: Department of Public Health, Nagasaki University Graduate School of Biomedical Science, 1-12-4, Sakamoto, Nagasaki-shi, Nagasaki, 852-8523, Japan. takayuki-n@nagasaki-u.ac.jp.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nishimura
authors.affiliation: Graduate School of Integrated Frontier Sciences, Kyushu University, 4-9-1 Shiobaru, Minamiku, Fukuoka, 815-8540, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Egashira
authors.affiliation: Graduate School of Integrated Frontier Sciences, Kyushu University, 4-9-1 Shiobaru, Minamiku, Fukuoka, 815-8540, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Kishida
authors.affiliation: Faculty of Design, Kyushu University, 4-9-1 Shiobaru, Minamiku, Fukuoka, 815-8540, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Watanuki
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics; D000328:Adult; D000532:Altitude Sickness / Q000097:blood / Q000235:genetics / Q000378:metabolism; D000885:Anthropology, Physical; D004272:DNA, Mitochondrial / Q000235:genetics; D006239:Haplotypes / Q000235:genetics / Q000502:physiology; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007564:Japan; D008297:Male; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011110:Polymorphism, Genetic / Q000235:genetics; D012881:Skin Temperature / Q000502:physiology*; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial; D010100:Oxygen
keywords: Hypobaric hypoxia; Mitochondrial haplogroup; SpO2