title: Left Ventricular Function Assessment Using 2 Different Cadmium-Zinc-Telluride Cameras Compared with a γ-Camera with Cardiofocal Collimators: Dynamic Cardiac Phantom Study and Clinical Validation.
abstract: This study compared two SPECT cameras with cadmium-zinc-telluride (CZT) detectors to a conventional Anger camera with cardiofocal collimators for the assessment of left ventricular (LV) function in a phantom and patients.
  
  
  METHODS
  A gated dynamic cardiac phantom was used. Eighteen acquisitions were processed on each CZT camera and the conventional camera. The total number of counts within a myocardial volume of interest varied from 0.25 kcts to 1.5 Mcts. Ejection fraction was set to 33%, 45%, or 60%. Volume, LV ejection fraction (LVEF), regional wall thickening, and motion (17-segment model) were assessed. One hundred twenty patients with a low pretest likelihood of coronary artery disease and normal findings on stress perfusion SPECT were retrospectively analyzed to provide the reference limits for end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction, and regional function for each camera model.
  
  
  RESULTS
  In the phantom study, for each ejection fraction value, volume was higher for the CZT cameras than for the conventional camera, resulting in a decreased but more accurate LVEF (all P < 0.001). In clinical data, body-surface-indexed EDV and ESV (mL/m(2)) were higher for one of the CZT cameras (Discovery NM 530c) than for the other (D-SPECT) or the conventional camera (respectively, 40.5 ± 9.2, 37 ± 7.9, and 35.8 ± 6.8 for EDV [P < 0.001] and 12.5 ± 5.3, 9.4 ± 4.2, and 8.3 ± 4.4 for ESV [P < 0.001]), resulting in a significantly decreased LVEF: 70.3% ± 9.1% vs. 75.2% ± 8.1% vs. 77.8% ± 9.3%, respectively (P < 0.001).
  
  
  CONCLUSIONS
  The new CZT cameras yielded global LV function results different from those yielded by the conventional camera. LV volume was higher for the Discovery NM 530c than for the D-SPECT or the conventional camera, leading to decreased LVEF in healthy subjects. These differences should be considered in clinical practice and warrant the collection of a specific reference database.
authors.affiliation: Nuclear Medicine, IRIS, Polyclinique du Bois, Lille, France Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France Normandie Université-EA4650, Caen, France abailliez@gmail.com.
authors.forename: Alban
authors.initials: A
authors.lastname: Bailliez
authors.affiliation: Nuclear Medicine, CHU de Toulouse, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lairez
authors.affiliation: Nuclear Medicine, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Merlin
authors.affiliation: Nuclear Medicine, CHU de Nantes, Nantes, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Piriou
authors.affiliation: Normandie Université-EA4650, Caen, France Cardiology, CHU de Caen, Caen, France; and.
authors.forename: Damien
authors.initials: D
authors.lastname: Legallois
authors.affiliation: Nuclear Medicine, IRIS, Polyclinique du Bois, Lille, France Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France Normandie Université-EA4650, Caen, France.
authors.forename: Tanguy
authors.initials: T
authors.lastname: Blaire
authors.affiliation: Normandie Université-EA4650, Caen, France Nuclear Medicine, CHU de Caen, Caen, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Agostini
authors.affiliation: Nuclear Medicine, CHU de Nantes, Nantes, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Valette
authors.affiliation: Normandie Université-EA4650, Caen, France Nuclear Medicine, CHU de Caen, Caen, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Manrique
mesh_terms: D019187:Cadmium Compounds / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D013691:Tellurium / Q000528:radiation effects; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation*; D014159:Transducers; D018487:Ventricular Dysfunction, Left; D017967:Zinc Compounds / Q000528:radiation effects
chemical_list: D019187:Cadmium Compounds; D017967:Zinc Compounds; D013691:Tellurium; C028337:cadmium telluride
keywords: CZT; cardiofocal collimators; dynamic phantom; left ventricular function; myocardial perfusion imaging; wall thickening