title: Subject-specific musculoskeletal modelling in patients before and after total hip arthroplasty.
abstract: The goal of this study was to define the effect on hip contact forces of including subject-specific moment generating capacity in the musculoskeletal model by scaling isometric muscle strength and by including geometrical information in control subjects, hip osteoarthritis and total hip arthroplasty patients. Scaling based on dynamometer measurements decreased the strength of all flexor and abductor muscles. This resulted in a model that lacked the capacity to generate joint moments required during functional activities. Scaling muscle forces based on functional activities and inclusion of MRI-based geometrical detail did not compromise the model strength and resulted in hip contact forces comparable to previously reported measured contact forces.
authors.affiliation: a KU Leuven, Department of Kinesiology, Human Movement Biomechanics Research Group , Heverlee , Belgium.
authors.forename: Mariska
authors.initials: M
authors.lastname: Wesseling
authors.affiliation: a KU Leuven, Department of Kinesiology, Human Movement Biomechanics Research Group , Heverlee , Belgium.
authors.forename: Friedl
authors.initials: F
authors.lastname: De Groote
authors.affiliation: b KU Leuven, Department of Rehabilitation Sciences, Neuromotor Rehabilitation , Heverlee , Belgium.|c Clinical Motion Analysis Laboratory , University Hospitals Leuven , Pellenberg , Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Meyer
authors.affiliation: d Hip Unit, Orthopaedic Department , Genk , Belgium.
authors.forename: Kristoff
authors.initials: K
authors.lastname: Corten
authors.affiliation: e UZ Pellenberg Orthopedic Department , University Hospitals Leuven , Pellenberg , Belgium.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Simon
authors.affiliation: b KU Leuven, Department of Rehabilitation Sciences, Neuromotor Rehabilitation , Heverlee , Belgium.|c Clinical Motion Analysis Laboratory , University Hospitals Leuven , Pellenberg , Belgium.
authors.forename: Kaat
authors.initials: K
authors.lastname: Desloovere
authors.affiliation: a KU Leuven, Department of Kinesiology, Human Movement Biomechanics Research Group , Heverlee , Belgium.
authors.forename: Ilse
authors.initials: I
authors.lastname: Jonkers
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D015992:Body Mass Index; D003198:Computer Simulation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D008954:Models, Biological; D009038:Motion; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism*; D015207:Osteoarthritis, Hip / Q000601:surgery; D016138:Walking / Q000502:physiology
keywords: Musculoskeletal modelling; hip osteoarthritis; imaging; moment generating capacity; patient-specific modelling; total hip arthroplasty