title: Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan.
abstract: Diabetic retinopathy (DR) is one of the most feared complications of diabetes and is a leading cause of acquired blindness in working adults. The prevalence of undiagnosed diabetes in Taiwan is about 4%, and the annual incidence of T2D (Type 2 Diabetes) in Taiwan is 1.8% following the 1985 WHO criteria. Multiple mechanisms have been shown in T2DR with some signaling pathways, including the polyol pathway, PKC pathway, AGEs pathway, and MAPK pathway. However, the cause of vision loss in diabetic retinopathy is complex and remains incompletely understood. Herein, we try to fully understand the new concepts regarding hyperglycemia-induced biochemical pathways contributing to DR pathophysiology. Our work may be able to provide new strategies for the prevention and treatment of diabetic vascular complications.
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Shih-Yin
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Department of Biological Science and Technology, China Medical University, 404, Taichung, Taiwan.
authors.forename: Yuan-Man
authors.initials: YM
authors.lastname: Hsu
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Ying-Ju
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Yu-Chuen
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Chao-Jung
authors.initials: CJ
authors.lastname: Chen
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Wei-De
authors.initials: WD
authors.lastname: Lin
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Liao
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Yng-Tay
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Wei-Yong
authors.initials: WY
authors.lastname: Lin
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan.
authors.forename: Yu-Huei
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan.
authors.forename: Jai-Sing
authors.initials: JS
authors.lastname: Yang
authors.affiliation: Institute of Biomedical Sciences, National Sun Yat-sen University, 804, Kaohsiung, Taiwan.
authors.forename: Jinn-Chyuan
authors.initials: JC
authors.lastname: Sheu
authors.affiliation: Genetics Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan. d0704@mail.cnuh.org.tw.|School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan. d0704@mail.cnuh.org.tw.|Department of Medical Genetics, China Medical University Hospital, 404, Taichung, Taiwan. d0704@mail.cnuh.org.tw.
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
keywords: Diabetic retinopathy (DR); Inflammation; Oxidative stress; Retina; Vascular damage