title: iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation.
abstract: GATA1 mutations and trisomy 21 are inextricably linked in the neonatal leukemia of children with Down syndrome (DS). A recent report by Banno et al. (2016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling hematopoietic abnormalities with patient-derived induced pluripotent stem cells.
authors.affiliation: Northwestern University, Division of Hematology/Oncology, 303 East Superior Street, Lurie 5-113, Chicago, IL 60611, USA.
authors.forename: Maureen
authors.initials: M
authors.lastname: McNulty
authors.affiliation: Northwestern University, Division of Hematology/Oncology, 303 East Superior Street, Lurie 5-113, Chicago, IL 60611, USA. Electronic address: j-crispino@northwestern.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Crispino
mesh_terms: D004314:Down Syndrome / Q000235:genetics*; D050982:GATA1 Transcription Factor / Q000235:genetics*; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D009154:Mutation
chemical_list: D050982:GATA1 Transcription Factor