title: Cardiac Contractility Modulation in a Model of Repaired Tetralogy of Fallot: A Sheep Model.
abstract: The onset of right ventricular dysfunction in patients presenting with congenital heart disease is associated with a dismal long-term outcome and often represents a therapeutic dead end. Our study had several objectives: (1) to analyse the anatomical, functional, histological and cellular characteristics of an animal model of repaired tetralogy of Fallot with right ventricular dysfunction (2) to test the new electrical treatment known as cardiac contractility modulation in this animal model. Seven sheep underwent a first surgery at the age of three weeks aiming to mimic the characteristics of a repaired tetralogy of Fallot. Five controls were sham-operated. Experimental studies were performed 12 months after the initial operation. The hemodynamic, echocardiographic, and mitochondrial function studies were carried out before and after cardiac contractility modulation in closed- and open-chest conditions. In this animal model of right ventricular dysfunction, short-term cardiac contractility modulation was associated with a significant improvement in (a) right ventricular function, as evidenced by a significant increase in right ventricular dP/dt (p < 0.05) (b) left ventricular function evidenced by the increase in left ventricular dP/dt max (p < 0.05) (c) in mitochondrial function (p < 0.05). In this animal model of chronic right ventricular dysfunction, cardiac contractility modulation significantly improved acute cardiac hemodynamic and mitochondrial functions of both ventricles and may represent a promising option in patients with right heart failure.
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Roubertie
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.|Cardiology Department, CHU Clermont-Ferrand, 63003, Clermont-Ferrand, France.|Clermont Université, ISIT-CaVITI, BP 10448, 63001, Clermont-Ferrand, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Eschalier
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Adlane
authors.initials: A
authors.lastname: Zemmoura
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Jean-Benoit
authors.initials: JB
authors.lastname: Thambo
authors.affiliation: University of Bordeaux, Maladies Rares: Génétique et Métabolisme (MRGM), EA 4576, 33000, Bordeaux, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Rooryck
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Labrousse
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Ploux
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ritter
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Haïssaguerre
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France.|University Hospital of Bordeaux, 33000, Bordeaux, France.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Dos Santos
authors.affiliation: University of Bordeaux 2, 33000, Bordeaux, France. bordacharp@hotmail.com.|University Hospital of Bordeaux, 33000, Bordeaux, France. bordacharp@hotmail.com.|L'institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France. bordacharp@hotmail.com.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bordachar
mesh_terms: D000818:Animals; D006352:Heart Ventricles; D009200:Myocardial Contraction; D012756:Sheep; D013771:Tetralogy of Fallot; D018497:Ventricular Dysfunction, Right; D016278:Ventricular Function, Right
keywords: Cardiac contractility modulation; Heart failure; Left ventricular function; Tetralogy of fallot