title: Comparative evaluation of oncologic outcomes in colon cancer.
abstract: OBJECTIVE
  In this paper we report clinical variables on colon cancer series. Oncological outcomes were compared to low-income and high-income countries.
  
  
  METHODS
  We analysed a prospective database of 51 colon cancer patients submitted to primary tumor resection between 2010 and 2011, showing clinical variables and oncologic outcomes.
  
  
  RESULTS
  R0 resection obtained in 80.4%, 21.6% of patients was TNM stage IV, and only 13.7% showed TNM stage I. Disease-free survival was 32 months, overall survival was 46 months, and the tumoral recurrence rate was 9.8%. Univariate analysis showed association of serum CEA levels ≥ 5 ng/dl (p= 0.004), presence of metastasis at diagnosis (p= 0.012), compromised surgical margins (p < 0.001) and poorer tumor differentiation (p= 0.041) to death. Multivariate analysis identified compromised surgical margins as an independent risk factor for death due to colon cancer (P=0.003; odds ratio=0.36; 95% confidence interval=0.004-0.33). Nowadays, 62.7% of patients are alive.
  
  
  CONCLUSIONS
  Recurrence rate, disease-free survival and overall survival was similar to those observed in more developed countries. Serum CEA levels ≥ 5 ng/dl, the presence of metastasis at diagnosis, compromised surgical margins and poorer tumor differentiation were associated with death. A compromised surgical margin was the only independent risk factor for death.
authors.affiliation: Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Mário Vinícius Angelete Alvarez
authors.initials: MV
authors.lastname: Bernardes
authors.affiliation: Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Marley Ribeiro
authors.initials: MR
authors.lastname: Feitosa
authors.affiliation: Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Fernanda Maris
authors.initials: FM
authors.lastname: Peria
authors.affiliation: Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Daniela Pretti da Cunha
authors.initials: DP
authors.lastname: Tirapelli
authors.affiliation: Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: José Joaquim Ribeiro da
authors.initials: JJ
authors.lastname: Rocha
authors.affiliation: Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Omar
authors.initials: O
authors.lastname: Feres
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D016208:Databases, Factual; D019049:Developed Countries; D003906:Developing Countries; D005260:Female; D006801:Humans; D007182:Income; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D002272:Carcinoembryonic Antigen