title: Human Pulp Response to Direct Pulp Capping and Miniature Pulpotomy with MTA after Application of Topical Dexamethasone: A Randomized Clinical Trial.
abstract: BACKGROUND
  The aim of this randomized clinical trial was to compare the histologic pulp tissue response to one-step direct pulp capping (DPC) and miniature pulpotomy (MP) with mineral trioxide aggregate (MTA) after application of dexamethasone in healthy human premolars.
  
  
  METHODS
  Forty intact premolars from 10 orthodontic patients, were randomly chosen for DPC (n=20) or MP (n=20). In 10 teeth from each group, after exposure of the buccal pulp horn, topical dexamethasone was applied over the pulp. In all teeth the exposed/miniaturely resected pulp tissue was covered with MTA and cavities were restored with glass ionomer. Teeth vitality was evaluated during the next 7, 21, 42, and 60 days. Signs and/or symptoms of irreversible pulpitis or pulp necrosis were considered as failure. According to the orthodontic schedule, after 60 days the teeth were extracted and submitted for histological examination. The Kruskal-Wallis and Fisher's exact tests were used for statistical analysis of the data (P=0.05).
  
  
  RESULTS
  Although dexamethasone specimens showed less inflammation, calcified bridge, pulpal blood vasculature, collagen fibers and granulation tissue formation were not significantly different between the groups (P>0.05).
  
  
  CONCLUSIONS
  Topical dexamethasone did not hindered pulp healing but reduced the amount of underlying pulpal tissue inflammation after DPC and MP in healthy human premolars.
authors.affiliation: Torabinejad Dental Research Center, Department of Endodontics, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran;
authors.forename: Seyed Amir
authors.initials: SA
authors.lastname: Mousavi
authors.affiliation: Dental Research Center, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran;
authors.forename: Jamileh
authors.initials: J
authors.lastname: Ghoddusi
authors.affiliation: Department of Oral Pathology, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran;
authors.forename: Nooshin
authors.initials: N
authors.lastname: Mohtasham
authors.affiliation: Dental Implant Research Center, Department of Oral and Maxillofacial Surgery, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran;
authors.forename: Shirin
authors.initials: S
authors.lastname: Shahnaseri
authors.affiliation: Department of Endodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
authors.forename: Payam
authors.initials: P
authors.lastname: Paymanpour
authors.affiliation: Department of Conservative Dentistry, Showa University Dental Hospital, Tokyo, Japan.
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Kinoshita
keywords: Dexamethasone; Direct Pulp Capping; Mineral Trioxide Aggregate; Miniature Pulpotomy; Vital Pulp Therapy