title: Device Thrombosis During Destination Therapy.
abstract: Device thrombosis remains a complication of long-term mechanical circulatory support with HeartMate II.
  
  
  
  Retrospective analysis of patients who underwent destination therapy (DT) with HeartMate II from January 2010-December 2013 at Tulane University Medical Center.
  
  
  
  Eighteen HeartMate II were implanted for DT. Survival rates were 72.2% at 1 year and 37% at 2 years. Device thrombosis in 7 of the 18 patients (39%) accounted for the low survival rate at 2 years. Known risk factors for device thrombosis were equally present in patients with and without device thrombosis. In contrast to patients without device thrombosis, all patients with device thrombosis had a pre-existing systemic inflammatory condition.
  
  
  
  Patients with pre-existing systemic inflammatory conditions are at risk of device thrombosis during DT.
authors.affiliation: Tulane University Heart and Vascular Institute, Tulane School of Medicine, New Orleans, Louisiana.
authors.forename: Rohan
authors.initials: R
authors.lastname: Samson
authors.affiliation: Division of Cardiology, University of Texas at Houston, Houston, Texas.
authors.forename: Indranee
authors.initials: I
authors.lastname: Rajapreyar
authors.affiliation: Tulane University Heart and Vascular Institute, Tulane School of Medicine, New Orleans, Louisiana.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Jaiswal
authors.affiliation: Tulane University Heart and Vascular Institute, Tulane School of Medicine, New Orleans, Louisiana.
authors.forename: Brian
authors.initials: B
authors.lastname: Payne
authors.affiliation: Tulane University Heart and Vascular Institute, Tulane School of Medicine, New Orleans, Louisiana.
authors.forename: Mark
authors.initials: M
authors.lastname: Cassidy
authors.affiliation: Tulane University Heart and Vascular Institute, Tulane School of Medicine, New Orleans, Louisiana.
authors.forename: Michael
authors.initials: M
authors.lastname: Weaver
authors.affiliation: Tulane University Heart and Vascular Institute, Tulane School of Medicine, New Orleans, Louisiana. Electronic address: lejemtel@tulane.edu.
authors.forename: Thierry H
authors.initials: TH
authors.lastname: Le Jemtel
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000628:therapy*; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D008145:Louisiana / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology / Q000401:mortality*
keywords: Destination therapy; Device thrombosis; HeartMate II; Left ventricular assist device