title: Evaluation of cardiac functions in juvenile systemic lupus erythematosus with two-dimensional speckle tracking echocardiography.
abstract: The aim of this study was to investigate subclinical systolic and diastolic dysfunction in juvenile-onset systemic lupus erythematosus (j-SLE) patients with speckle tracking echocardiography (STE) and the effects of disease activity on left ventricular (LV) regional functions. Thirty-five patients with j-SLE and 30 healthy children (control group) were evaluated between January and August 2015. STE was performed on all patients and controls. Medical records, including diagnosis criteria, age at diagnosis, and duration of disease, were evaluated. SLE disease activity was assessed using the SLE Disease Activity Index (SLEDAI). j-SLE patients had lower ejection fraction than did control subjects but still within normal range. LV end-diastolic and end-systolic dimensions were significantly larger in j-SLE patients (32.43 ± 3.2 vs 28.3 ± 3.1 and 21.1 ± 1.9 vs 18.9.0 ± 2.2, respectively; p = 0.001). There was a significant reduction in longitudinal strain of LV segments in the j-SLE patients compared with controls. J-SLE patients were further divided into subgroups. Group 1 comprised patients having SLEDAI scores >8 at the onset of disease but who improved with therapy during follow-up. Group 2 included j-SLE patients with SLEDAI scores >8 at diagnosis and persistently >4 at the end of follow-up. In the LV mid-inferior and mid-inferolateral segments, STE strain measurements of group 2 were significantly lower than those of group 1 (15.9 ± 6.4 vs 20.0 ± 4.4, 17.9 ± 7.2 vs 23.2 ± 3.8; p = 0.075, p = 0.055, respectively). Simple and non-invasive STE would be helpful in predicting cardiovascular prognosis with new therapeutic medications/interventions or in objectively comparing the effects of immunosuppressive drugs in comparison with preceding STE evaluation.
authors.affiliation: Pediatric Cardiology, Cerrahpasa Medical Faculty, Department of Pediatric Cardiology, Istanbul University, Istanbul, Turkey. reyhandedeoglu@gmail.com.
authors.forename: Reyhan
authors.initials: R
authors.lastname: Dedeoglu
authors.affiliation: Pediatric Rheumatology, Cerrahpasa Medical Faculty, Department of Pediatric Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Sezgin
authors.initials: S
authors.lastname: Şahin
authors.affiliation: Pediatric Cardiology, Cerrahpasa Medical Faculty, Department of Pediatric Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Aida
authors.initials: A
authors.lastname: Koka
authors.affiliation: Pediatric Cardiology, Cerrahpasa Medical Faculty, Department of Pediatric Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Öztunç
authors.affiliation: Pediatric Rheumatology, Cerrahpasa Medical Faculty, Department of Pediatric Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Amra
authors.initials: A
authors.lastname: Adroviç
authors.affiliation: Pediatric Rheumatology, Cerrahpasa Medical Faculty, Department of Pediatric Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Barut
authors.affiliation: Department of Statistics, Istanbul Commerce University, Istanbul, Turkey.
authors.forename: Dicle
authors.initials: D
authors.lastname: Cengiz
authors.affiliation: Pediatric Rheumatology, Cerrahpasa Medical Faculty, Department of Pediatric Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kasapçopur
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D013256:Steroids / Q000627:therapeutic use; D013599:Systole; D014421:Turkey; D016277:Ventricular Function, Left
chemical_list: D013256:Steroids
keywords: SLEDAI; Speckle tracking echocardiography; Systolic dysfunction; Systolic strain; j-SLE