title: High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses.
abstract: The current Zika virus (ZIKV) epidemic in the Americas caused an increase in diagnostic requests in European countries. Here we demonstrate high specificity of the Euroimmun anti-ZIKV IgG and IgM ELISA tests using putative cross-reacting sera of European patients with antibodies against tick-borne encephalitis virus, dengue virus, yellow fever virus and hepatitis C virus. This test may aid in counselling European travellers returning from regions where ZIKV is endemic.
authors.affiliation: Institute for Virology, Medical Center - University of Freiburg, Freiburg, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Huzly
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Hanselmann
authors.forename: Jonas
authors.initials: J
authors.lastname: Schmidt-Chanasit
authors.forename: Marcus
authors.initials: M
authors.lastname: Panning
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D004781:Environmental Exposure; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D015995:Prevalence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D000071244:Zika Virus / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification*; D000071243:Zika Virus Infection / Q000097:blood* / Q000453:epidemiology / Q000821:virology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: ELISA; European travellers; Zika virus; cross-reactivity; flavivirus; specificity