title: Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources.
abstract: MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.
authors.affiliation: Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, 02215, United States of America.
authors.forename: Ravi
authors.initials: R
authors.lastname: Shah
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, United States of America.
authors.forename: Kahraman
authors.initials: K
authors.lastname: Tanriverdi
authors.affiliation: The Framingham Heart Study, Framingham, MA, United States of America and Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
authors.forename: Daniel
authors.initials: D
authors.lastname: Levy
authors.affiliation: The Framingham Heart Study, Framingham, MA, United States of America and Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
authors.forename: Martin
authors.initials: M
authors.lastname: Larson
authors.affiliation: Yale University Medical School, Computational Biology & Bioinformatics Program, New Haven, CT, 06520, United States of America.
authors.forename: Mark
authors.initials: M
authors.lastname: Gerstein
authors.affiliation: University of Massachusetts Medical School, Department of Quantitative Health Sciences, Worcester, MA, 01605, United States of America.
authors.forename: Eric
authors.initials: E
authors.lastname: Mick
authors.affiliation: Yale University Medical School, Computational Biology & Bioinformatics Program, New Haven, CT, 06520, United States of America.
authors.forename: Joel
authors.initials: J
authors.lastname: Rozowsky
authors.affiliation: Yale University Medical School, Computational Biology & Bioinformatics Program, New Haven, CT, 06520, United States of America.
authors.forename: Robert
authors.initials: R
authors.lastname: Kitchen
authors.affiliation: Department of Cardiology, University of Michigan, Ann Arbor, Michigan, 1500 E. Medical Center Dr. SPC 5873, Ann Arbor, MI, 48109, United States of America.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Murthy
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, United States of America.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Mikalev
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, United States of America.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Freedman
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D010949:Plasma / Q000378:metabolism; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D035683:MicroRNAs