title: Posterior fossa involvement in the diagnosis of adult-onset inherited leukoencephalopathies.
abstract: Adult-onset genetic leukoencephalopathies are increasingly recognized. They are heterogeneous groups of disorders that commonly have distinct pathologic mechanisms but they share the presence of supratentorial bilateral and symmetric white matter hyperintensities. Although these abnormalities are usually non-specific, some specific MRI findings exist and sometimes help to distinguish these disorders. In this review, our aim is to describe posterior fossa abnormalities seen in the main adult-onset genetic leukoencephalopathies enabling clinicians to perform oriented genetic/metabolic screening.
authors.affiliation: Service de Neurologie, CHU de Montpellier, Hôpital Gui De Chauliac, 80 Av Augustin FLICHE, 34295, Montpellier, France. xavier.ayrignac@yahoo.fr.|Institut des Neurosciences Montpellier (INM), Inserm UMR1051, Hôpital Saint-Eloi, Montpellier, France. xavier.ayrignac@yahoo.fr.
authors.forename: Xavier
authors.initials: X
authors.lastname: Ayrignac
authors.affiliation: Service de Neurologie, Pôle de Neurosciences Cliniques, APHM, Hôpital de la Timone, Marseille, France.
authors.forename: Clemence
authors.initials: C
authors.lastname: Boutiere
authors.affiliation: Service de Neurologie, CHU de Montpellier, Hôpital Gui De Chauliac, 80 Av Augustin FLICHE, 34295, Montpellier, France.
authors.forename: Clarisse
authors.initials: C
authors.lastname: Carra-Dalliere
authors.affiliation: Service de Neurologie, CHU de Montpellier, Hôpital Gui De Chauliac, 80 Av Augustin FLICHE, 34295, Montpellier, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Labauge
mesh_terms: D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging; D006801:Humans; D056784:Leukoencephalopathies / Q000235:genetics* / Q000473:pathology*; D008279:Magnetic Resonance Imaging
keywords: Genetic; Leukodystrophy; Leukoencephalopathy; MRI; White matter disease