title: Non-coding RNAs as emerging molecular targets of gallbladder cancer.
abstract: Gallbladder cancer is one of the most common cancers of biliary tract with aggressive pathophysiology, now emerging as a global health issue. Although minority of gallbladder cancer patients could receive such curative resection due to late diagnosis, this increases the survival rate. Lack of potential target molecule (s) for early diagnosis, better prognosis and effective therapy of gallbladder cancer has triggered investigators to look for novel technological or high throughput approaches to identify potential biomarker for gallbladder cancer. Intervention of non-coding RNAs in gallbladder cancer has been revealed recently. Non-coding RNAs are now widely implicated in cancer. Recent reports have revealed association of non-coding RNAs (microRNAs or miRNAs and long non-coding RNAs or lncRNAs) with gallbladder cancer. Here, we present an updated overview on the biogenesis, mechanism of action, role of non-coding RNAs, the identified cellular functions in gallbladder tumorigenesis, their prognostic & therapeutic potentials (efficacies) and future significance in developing effective biomarker(s), in future, for gallbladder.
authors.affiliation: Centre for Genomics, Molecular and Human Genetics, Jiwaji University, Gwalior 474 011, MP, India.
authors.forename: Dinesh Singh
authors.initials: DS
authors.lastname: Tekcham
authors.affiliation: Centre for Genomics, Molecular and Human Genetics, Jiwaji University, Gwalior 474 011, MP, India. Electronic address: pktiwari.ju@gmail.com.
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Tiwari
mesh_terms: D014408:Biomarkers, Tumor; D063646:Carcinogenesis; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors*; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000037:antagonists & inhibitors*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: Biomarker; Gallbladder cancer; Long non-coding RNAs; MicroRNA