title: Widespread 3'-end uridylation in eukaryotic RNA viruses.
abstract: RNA 3' uridylation occurs pervasively in eukaryotes, but is poorly characterized in viruses. In this study, we demonstrate that a broad array of RNA viruses, including mycoviruses, plant viruses and animal viruses, possess a novel population of RNA species bearing nontemplated oligo(U) or (U)-rich tails, suggesting widespread 3' uridylation in eukaryotic viruses. Given the biological relevance of 3' uridylation to eukaryotic RNA degradation, we propose a conserved but as-yet-unknown mechanism in virus-host interaction.
authors.affiliation: Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Yayun
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Inspection &Quarantine Technology Center, Fujian Entry-Exit Inspection and Quarantine Bureau, Fuzhou, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Shen
authors.affiliation: Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Huanian
authors.initials: H
authors.lastname: Wu
authors.affiliation: Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Guo
authors.affiliation: Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, China.
authors.forename: Jinguang
authors.initials: J
authors.lastname: Yang
authors.affiliation: Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Li
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D056890:Eukaryota / Q000821:virology; D005658:Fungi; D010944:Plants; D011072:Poly U / Q000378:metabolism*; D012328:RNA Viruses / Q000502:physiology*; D012367:RNA, Viral / Q000378:metabolism*
chemical_list: D020413:3' Untranslated Regions; D012367:RNA, Viral; D011072:Poly U