title: Liquid fructose in pregnancy exacerbates fructose-induced dyslipidemia in adult female offspring.
abstract: Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and related events. Nevertheless, consumption of beverages sweetened with fructose is not regulated in gestation. Previously, we found that maternal fructose intake produces in the progeny, when fetuses, impaired leptin signaling and hepatic steatosis and then impaired insulin signaling and hypoadiponectinemia in adult male rats. Interestingly, adult females from fructose-fed mothers did not exhibit any of these disturbances. However, we think that, actually, these animals keep a programmed phenotype hidden. Fed 240-day-old female progeny from control, fructose- and glucose-fed mothers were subjected for 3weeks to a fructose supplementation period (10% wt/vol in drinking water). Fructose intake provoked elevations in insulinemia and adiponectinemia in the female progeny independently of their maternal diet. In accordance, the hepatic mRNA levels of several insulin-responsive genes were similarly affected in the progeny after fructose intake. Interestingly, adult progeny of fructose-fed mothers displayed, in response to the fructose feeding, augmented plasma triglyceride and NEFA levels and hepatic steatosis versus the other two groups. In agreement, the expression and activity for carbohydrate response element binding protein (ChREBP), a lipogenic transcription factor, were higher after the fructose period in female descendants from fructose-fed mothers than in the other groups. Furthermore, liver fructokinase expression that has been indicated as one of those responsible for the deleterious effects of fructose ingestion was preferentially augmented in that group. Maternal fructose intake does influence the adult female offspring's response to liquid fructose and so exacerbates fructose-induced dyslipidemia and hepatic steatosis.
authors.affiliation: Facultad de Farmacia, Universidad San Pablo-CEU, Montepríncipe, Boadilla del Monte, Madrid, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Rodríguez
authors.affiliation: Facultad de Farmacia, Universidad San Pablo-CEU, Montepríncipe, Boadilla del Monte, Madrid, Spain.
authors.forename: María I
authors.initials: MI
authors.lastname: Panadero
authors.affiliation: Facultad de Farmacia, Universidad San Pablo-CEU, Montepríncipe, Boadilla del Monte, Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Rodrigo
authors.affiliation: Facultad de Farmacia, Universidad de Barcelona, CIBERobn, IBUB, Barcelona, Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Roglans
authors.affiliation: Facultad de Farmacia, Universidad San Pablo-CEU, Montepríncipe, Boadilla del Monte, Madrid, Spain.
authors.forename: Paola
authors.initials: P
authors.lastname: Otero
authors.affiliation: CQS Lab, Madrid, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Álvarez-Millán
authors.affiliation: Facultad de Farmacia, Universidad de Barcelona, CIBERobn, IBUB, Barcelona, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Laguna
authors.affiliation: Facultad de Farmacia, Universidad San Pablo-CEU, Montepríncipe, Boadilla del Monte, Madrid, Spain. Electronic address: carbocos@ceu.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Bocos
mesh_terms: D052242:Adiponectin / Q000819:agonists / Q000097:blood; D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D001628:Beverages / Q000009:adverse effects*; D050171:Dyslipidemias / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D005230:Fatty Acids, Nonesterified / Q000819:agonists / Q000097:blood; D005260:Female; D047109:Fetal Development; D005631:Fructokinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005632:Fructose / Q000009:adverse effects*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005947:Glucose / Q000009:adverse effects; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D039382:Maternal Nutritional Physiological Phenomena; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D064427:Nutritive Sweeteners / Q000009:adverse effects*; D011247:Pregnancy; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000819:agonists / Q000097:blood
chemical_list: D052242:Adiponectin; C499920:Adipoq protein, rat; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D005230:Fatty Acids, Nonesterified; C442825:Mlxipl protein, rat; D064427:Nutritive Sweeteners; D014280:Triglycerides; D005632:Fructose; D005631:Fructokinases; D005947:Glucose
keywords: Dyslipidemia; Fetal programming; Fructokinase; Fructose; Pregnancy