title: Comparison of paracetamol and fentanyl for pain relief during and after suction termination.
abstract: OBJECTIVE
  To compare the combination of paracetamol (20 mg/kg) and propofol to fentanyl (1 µg/kg) and propofol in terms of providing adequate analgesia and a comparable recovery profile in suction termination procedures.
  
  
  METHODS
  This is a prospective, randomized clinical study in which we obtained informed consents from 146 women (fentanyl group: 76 [52.1%], paracetamol group: 70 [47.9%]) who were scheduled for suction curettage at the Istanbul Kanuni Sultan Suleyman Education and Training Hospital, Istanbul, Turkey in January 2015. Patients were randomly allocated into a fentanyl group or a paracetamol group. Visual analogue scores, modified Aldrete scores, and hemodynamic parameters were recorded during and after the surgical procedure. A record was also maintained of any adverse events.
  
  
  RESULTS
  When the modified Aldrete scores at 60 minutes, systolic pressures at 0 minutes, oxygen saturation at 10, 15, 20 minutes, diastolic blood pressure at 10, 15, 20 minutes, heart rates, and visual analogue scores were compared, there was no significant difference between groups (p greater than 0.05). In the fentanyl group, systolic blood pressures at 5, 10, 15, 20 minutes and diastolic blood pressure at 5 minutes and oxygen saturation at 5 minutes were significantly lower (p less than 0.05).
  
  
  CONCLUSIONS
  Our study demonstrates that the analgesic properties and recovery profiles of intravenous paracetamol is as effective as fentanyl when used in suction termination procedures. Further larger studies are still required.
authors.affiliation: Department of Anesthesiology and Reanimation, Istanbul Kanuni Sultan Suleyman Education and Research Hospital, Istanbul, Turkey. E-mail. aycasultan@gmail.com.
authors.forename: Ayça S
authors.initials: AS
authors.lastname: Şahin
authors.forename: Aykan
authors.initials: A
authors.lastname: Gülleroğlu
authors.forename: Melike K
authors.initials: MK
authors.lastname: Toker
authors.forename: Ayse G
authors.initials: AG
authors.lastname: Karabay
authors.forename: Ozal
authors.initials: O
authors.lastname: Adıyeke
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Demiraran
mesh_terms: D000028:Abortion, Induced; D000082:Acetaminophen / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D005283:Fentanyl / Q000627:therapeutic use*; D006801:Humans; D059408:Pain Management / Q000379:methods*; D011446:Prospective Studies; D013396:Suction; D014421:Turkey
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000082:Acetaminophen; D005283:Fentanyl