title: METTL3 Gains R/W Access to the Epitranscriptome.
abstract: Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.
authors.affiliation: EMBL - Australia Collaborating Group, Department of Genome Sciences, The John Curtin School of Medical Research (JCSMR), The Australian National University, Acton (Canberra), ACT 2601, Australia.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Schumann
authors.affiliation: EMBL - Australia Collaborating Group, Department of Genome Sciences, The John Curtin School of Medical Research (JCSMR), The Australian National University, Acton (Canberra), ACT 2601, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Shafik
authors.affiliation: EMBL - Australia Collaborating Group, Department of Genome Sciences, The John Curtin School of Medical Research (JCSMR), The Australian National University, Acton (Canberra), ACT 2601, Australia; Victor Chang Cardiac Research Institute, Darlinghurst (Sydney), NSW 2010, Australia. Electronic address: thomas.preiss@anu.edu.au.
authors.forename: Thomas
authors.initials: T
authors.lastname: Preiss
mesh_terms: D008780:Methyltransferases / Q000235:genetics; D012313:RNA / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D012313:RNA; D008780:Methyltransferases