title: RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function.
abstract: Recent human and mouse genetic studies have highlighted important contributions of several small GTPases, in particular Rab8a, (1) Cdc42, (2-4) and Rab11a, (5-8) to the proper morphogenesis and function of the mature intestinal epithelia. Additional insights about the involvement of these factors in maintaining intestinal stem cell homeostasis have also been obtained. (9,10) These studies suggest a conserved vesicular and membrane trafficking program utilized by the gastrointestinal tissue to support the rapid epithelial cell turnover and the highly sophisticated physiology of mature epithelial cells.
authors.affiliation: a Department of Biological Sciences , Rutgers University , Newark , NJ , USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: a Department of Biological Sciences , Rutgers University , Newark , NJ , USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Gao
mesh_terms: D000818:Animals; D020895:Enterocytes / Q000166:cytology* / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D007410:Intestinal Diseases / Q000378:metabolism / Q000473:pathology; D055153:Stem Cell Niche; D020691:rab GTP-Binding Proteins / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020691:rab GTP-Binding Proteins; D020741:rho GTP-Binding Proteins
keywords: CDC42; Microvillus Inclusion Disease; Paneth cell; RAB11; RAB8; Wnt secretion; enterocyte; intestinal stem cell; stem cell niche