title: Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation.
abstract: In this study, we assessed whether multisystem reactions to egg and extensively-heated (EH) egg during OFCs were associated with a history of multisystem reactions. Records of children, who underwent OFC to egg or EH egg over a five-year period were reviewed. Of the 120 challenges, 26 (21.67 %) failed, with 38.4 % (10/26) having multisystem reactions. Of the 13 who had multisystem reactions on initial presentation, only two (15.4 %) had a similar OFC outcome. Eighty percent (8/10) of those who had a multisystem OFC reaction had a less severe initial presentation. Initial and OFC multisystem reactions were not associated with each other.
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, 705 Riley Hospital Drive, ROC 4270, Indianapolis, IN 46202 USA.
authors.forename: Girish
authors.initials: G
authors.lastname: Vitalpur
authors.affiliation: Department of Pediatrics, University of Wisconsin-Madison, Madison, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Esquivel
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, 705 Riley Hospital Drive, ROC 4270, Indianapolis, IN 46202 USA.
authors.forename: Kirsten M
authors.initials: KM
authors.lastname: Kloepfer
authors.affiliation: Department of Biostatistics and Public Health, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Slaven
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, 705 Riley Hospital Drive, ROC 4270, Indianapolis, IN 46202 USA.
authors.forename: Frederick E
authors.initials: FE
authors.lastname: Leickly
keywords: Egg allergy; Extensively heated (EH) egg allergy; Oral food challenge (OFC); Reaction severity; Type of reaction