title: MicroRNA-23b regulates nasopharyngeal carcinoma cell proliferation and metastasis by targeting E-cadherin.
abstract: MicroRNA-23b (miR-23b) is important in tumor proliferation and metastasis. In this study, it was suggested that the levels of miR-23b were increased in nasopharyngeal carcinoma (NPC) tissues compared with the adjacent normal tissues. The present study aimed to explore the role of miR‑23b upregulation in NPC. Functional studies demonstrated that inhibition of miR‑23b could significantly suppress NPC cell proliferation, migration and invasion. An in vitro reporter assay suggested that E‑cadherin is a direct target gene of miR‑23b. Furthermore, the expression of miR‑23b in NPC tissues was inversely correlated with that of E‑cadherin. These findings provide evidence that miR‑23b is key in promoting NPC cell proliferation, migration and invasion through targeting E‑cadherin, and strongly suggests that an exogenous miR‑23b inhibitor may have therapeutic value in treating NPC.
authors.affiliation: Department of ENT, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Department of ENT, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Li
authors.affiliation: Department of ENT, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
authors.forename: Pei-Zhong
authors.initials: PZ
authors.lastname: Li
authors.affiliation: Department of ENT, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of ENT, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of ENT, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000368:Aged; D001665:Binding Sites; D015820:Cadherins / Q000235:genetics*; D002277:Carcinoma; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D034622:RNA Interference
chemical_list: D020413:3' Untranslated Regions; D015820:Cadherins; C552430:MIRN23a microRNA, human; D035683:MicroRNAs