title: Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy.
abstract: Proton magnetic resonance spectroscopy (1H-MRS) enables the assessment of myocardial triglyceride (TG) content, which is reported to be associated with cardiac dysfunction and morphology accompanied by metabolic disorder and cardiac hemodynamic status. The clinical usefulness of myocardial TG content measurements in patients with left ventricular hypertrophy (LVH) has not been fully investigated. We examined whether myocardial TG content assessed by1H-MRS was useful for diagnosis in patients with LVH. To quantify myocardial TG content, we conducted1H-MRS in 35 subjects with LVH. Left ventricular function was measured by cardiac magnetic resonance imaging. Patients were assigned to a hypertensive heart disease (HHD, n = 10) or hypertrophic cardiomyopathy (HCM, n = 25) group based on the histology and/or late gadolinium enhancement pattern. The myocardial TG content was significantly higher in the HHD group than in the HCM group (2.14 ± 1.29 vs. 1.09 ± 0.72 %, P < 0.001). Myocardial TG content were significantly and negatively correlated with LV mass (r = -0.41, P < 0.04) and stroke volume (r = -0.64, P < 0.05) in the HCM group and HHD group, respectively. In a multivariate analysis, LV mass volume and diagnosis of HCM or HHD were independent factors of the myocardial TG content. The results suggest that myocardial metabolism may differ between HCM and HHD patients and that measurement of myocardial TG content by1H-MRS may be useful for evaluating the myocardial metabolic features of LVH.
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.
authors.forename: Eiryu
authors.initials: E
authors.lastname: Sai
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan. shimakaz@juntendo.ac.jp.|Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan. shimakaz@juntendo.ac.jp.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimada
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yokoyama
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hiki
authors.affiliation: Department of Radiology, Juntendo University Hospital, Tokyo, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Radiology, Juntendo University Hospital, Tokyo, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Hamasaki
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Maruyama
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Morimoto
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Fujimoto
authors.affiliation: Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.|Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.affiliation: Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.|Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Watada
authors.affiliation: Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.|Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamori
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, Japan.|Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
mesh_terms: D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging*; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D013318:Stroke Volume; D014280:Triglycerides / Q000032:analysis*; D016277:Ventricular Function, Left
chemical_list: D014280:Triglycerides; D005682:Gadolinium
keywords: Left ventricular hypertrophy; Magnetic resonance spectroscopy; Myocardial triglyceride content