title: Context-dependent effects of cellular senescence in cancer development.
abstract: Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associated secretory phenotype (SASP). Moreover, new insights suggest the SASP can facilitate tissue repair. Here, we review the beneficial and detrimental roles of senescent cells, highlighting conditions under which the senescence response does and does not promote pathology, particularly cancer. By better understanding the context-dependent effects of cellular senescence, it may be feasible to limit its detrimental properties while preserving its beneficial effects, and develop novel therapeutic strategies to prevent or treat cancer and possibly other age-associated diseases.
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors.forename: Pacome
authors.initials: P
authors.lastname: Lecot
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors.forename: Fatouma
authors.initials: F
authors.lastname: Alimirah
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.|California Pacific Medical Center, 475 Brannan Street, San Francisco, CA 94107, USA.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Desprez
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.|Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Wiley
mesh_terms: D000818:Animals; D002455:Cell Division; D060833:Cellular Microenvironment; D016922:Cellular Senescence / Q000502:physiology*; D047108:Embryonic Development; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D051379:Mice; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D010641:Phenotype; D012038:Regeneration