title: The Diagnostic Value of Gastrin-17 Detection in Atrophic Gastritis: A Meta-Analysis.
abstract: A meta-analysis was performed to assess the diagnostic value of gastrin-17 (G-17) for the early detection of chronic atrophic gastritis (CAG).An extensive literature search was performed, with the aim of selecting publications that reported the accuracy of G-17 in predicting CAG, in the following databases: PubMed, Science Direct, Web of Science, Chinese Biological Medicine, Chinese National Knowledge Infrastructure, Wanfang, and VIP. To assess the diagnostic value of G-17, the following statistics were estimated and described: sensitivity, specificity, diagnostic odds ratios (DOR), summary receiver operating characteristic curves, area under the curve (AUC), and 95% confidence intervals (CIs).Thirteen studies that met the inclusion criteria were included in this meta-analysis, comprising 894 patients and 1950 controls. The pooled sensitivity and specificity of these studies were 0.48 (95% CI: 0.45-0.51) and 0.79 (95% CI: 0.77-0.81), respectively. The DOR was 5.93 (95% CI: 2.93-11.99), and the AUC was 0.82.G-17 may have potential diagnostic value because it has good specificity and a moderate DOR and AUC for CAG. However, more studies are needed to improve the sensitivity of this diagnostic tool in the future.
authors.affiliation: From the Scientific Research Office, the Children's Hospital of Anhui Province, Hefei, Anhui Province, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Ling
authors.forename: Shanshan
authors.initials: S
authors.lastname: Li
authors.forename: Guiping
authors.initials: G
authors.lastname: Qin
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Ni
mesh_terms: D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D005755:Gastrins / Q000097:blood*; D005757:Gastritis, Atrophic / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D005755:Gastrins; C013550:gastrin 17