title: Histopathological Aspects Described in Patients with Hepatic Hydatidosis.
abstract: BACKGROUND
  Hydatidosis is a parasitic disease with tumour-like development of a cystic mass. This has specific endemic areas, Romania being amongst them. Our hospital has national addressability and the collaboration between the Departments of Parasitology, General Surgery and Pathology ensures optimal multidisciplinary approach to cases of therapeutic and diagnostic standpoint. The study aims to test the hypothesis that the gallbladder is a hydatid reservoir, to identify signs of biliary fistulas in the pericyst and liver parenchyma; to identify inflammation elements in the pericyst and the gallbladder.
  
  
  METHODS
  The study is a retrospective observational one, carried out between 2011-2014, on a total of 35 patients operated for hepatic hydatidosis in the General Surgery Department of "Colentina" Clinical Hospital. All the selected patients had sent to the Pathology Department: gallbladder, cyst and pericyst. Statistical analysis of the data was performed using SPSS package Statistics 19.
  
  
  RESULTS
  The main results of the study revealed no evidence to confirm the hypothesis that the gallbladder is a hydatid reservoir. Out of the 35 cases, in 16 we observed the tendency to include hepatic biliary ducts in the pericyst or the formation of new canals which lead to the formation of biliary fistulas. Using immunohistochemical techniques with mark of CK19 (cytokeratin 19), have been observed the pattern of fistulization and modification of local architecture through the formation of the pericyst, in 16/35 (45.7%) of cases.
  
  
  CONCLUSIONS
  Although it is a benign pathology, the evolution of hepatic hydatidosis can lead to severe complications and a low quality of life for the patient, both before and after surgery. Better knowledge of the pathology behind the local evolution of the disease can influence the therapeutic approach.
authors.forename: Daniela E
authors.initials: DE
authors.lastname: Mihăilă
authors.forename: M C
authors.initials: MC
authors.lastname: Nitu
authors.forename: T D
authors.initials: TD
authors.lastname: Potecă
mesh_terms: D000328:Adult; D001658:Biliary Fistula / Q000469:parasitology / Q000473:pathology*; D015331:Cohort Studies; D004444:Echinococcosis, Hepatic / Q000473:pathology*; D005260:Female; D005704:Gallbladder / Q000469:parasitology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D053539:Keratin-19 / Q000378:metabolism; D008099:Liver / Q000469:parasitology / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies
chemical_list: D053539:Keratin-19