title: Effectiveness of Magnifying Narrow-Band Imaging Endoscopy for Differential Diagnosis between the High-Risk Mixed-Type and Low-Risk Simple-Type of Low-Grade, Well-Differentiated Gastric Tubular Adenocarcinoma.
abstract: Backgrounds. Magnifying endoscopy with narrow-band imaging (NBI-ME) is useful for diagnosing differentiated early gastric cancer (D-EGC). D-EGC is classified as high- or low-grade based on its glandular architectural and cytological atypia. Low-grade, well-differentiated tubular adenocarcinoma (LG-tub1) mixed with high-grade tub1 (HG-tub1) and/or other histological types (M-LG-tub1) may indicate a primitive high-risk malignant lesion compared to histologically simple-type LG-tub1 (S-LG-tub1). Because LG-tub1 is occasionally difficult to diagnose due to its unclear demarcation under conventional white light endoscopy, early precise diagnoses are important. Methods. We compared NBI-ME and postendoscopic submucosal dissection histological findings for 30 S-LG-tub1 and 15 M-LG-tub1 lesions. We classified the NBI-ME findings of S-LG-tub1 (and not D-EGC) into four patterns. The differential diagnosis between M-LG-tub1 and S-LG-tub1 depended on the presence of more than one of these patterns without or with other patterns (referred to as "limited-to-four-pattern [LFP] sign-positive" and "sign-negative", resp.). Result. The sensitivity, specificity, accuracy, positive and negative predictive values, and intraobserver and interobserver agreement, using the "LFP sign" for the differential diagnosis between M-LG-tub1 and S-LG-tub1, were 87.9%, 91.7%, 88.9%, 96.7%, 73.3%, and k = 0.842 and k = 0.737, respectively. Conclusion. NBI-ME may be useful in differentiating between high-risk M-LG-tub1 and low-risk S-LG-tub1.
authors.affiliation: Department of Gastrointestinal Endoscopy and Gastroenterology, Niigata Prefectural Federation of Japan Agricultural Cooperatives, Toyosaka Hospital, 1-11-1 Isurugi, Kita-ku, Niigata 950-3327, Japan; Division of Gastrointestinal Endoscopy and Gastroenterology, Niigata Prefectural Kamo Hospital, 1-9-1 Aomi-cho, Kamo, Niigata 959-1326, Japan.
authors.forename: Takashi
authors.identifier: 0000-0002-8330-2180
authors.initials: T
authors.lastname: Saitoh
authors.affiliation: Department of Gastrointestinal Endoscopy and Gastroenterology, Niigata Prefectural Federation of Japan Agricultural Cooperatives, Toyosaka Hospital, 1-11-1 Isurugi, Kita-ku, Niigata 950-3327, Japan.
authors.forename: Asako
authors.initials: A
authors.lastname: Takamura
authors.affiliation: Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Watanabe
authors.affiliation: Department of Gastrointestinal Endoscopy and Gastroenterology, Niigata Prefectural Federation of Japan Agricultural Cooperatives, Toyosaka Hospital, 1-11-1 Isurugi, Kita-ku, Niigata 950-3327, Japan.
authors.forename: Suzuko
authors.initials: S
authors.lastname: Sugitani
authors.affiliation: Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ajioka