title: Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals.
abstract: Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection. General linear models tested whether the number of driving errors differed as a function of each of the biomarker variables (mean cortical binding potential for PIB, and CSF Aβ42, tau, ptau181, tau/Aβ42, ptau181/Aβ42). Higher ratios of CSF tau/Aβ42, ptau181/Aβ42, and PIB mean cortical binding potential, were associated with more driving errors (P<0.05). Preclinical AD may have subtle cognitive and functional effects, which alone may go unnoticed. However, when combined, these changes may impact complex behaviors such as driving.
authors.affiliation: *Charles F. and Joanne Knight Alzheimer's Disease Research Center Departments of †Neurology ‡Occupational Therapy ∥Psychology ¶¶Pathology and Immunology ##Physical Therapy **Radiology §§Neurosurgery ∥∥Medicine ¶Center for Clinical Studies #Division of Biostatistics, Washington University School of Medicine, St. Louis, MO §The Rehabilitation Institute of St. Louis ††The Alzheimer's Disease & Memory Disorders Center, Alpert Medical School of Brown University ‡‡Rhode Island Hospital, Providence, Rhode Island.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Roe
authors.forename: Peggy P
authors.initials: PP
authors.lastname: Barco
authors.forename: Denise M
authors.initials: DM
authors.lastname: Head
authors.forename: Nupur
authors.initials: N
authors.lastname: Ghoshal
authors.forename: Natalie
authors.initials: N
authors.lastname: Selsor
authors.forename: Ganesh M
authors.initials: GM
authors.lastname: Babulal
authors.forename: Rebecca
authors.initials: R
authors.lastname: Fierberg
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Vernon
authors.forename: Neal
authors.initials: N
authors.lastname: Shulman
authors.forename: Ann
authors.initials: A
authors.lastname: Johnson
authors.forename: Scot
authors.initials: S
authors.lastname: Fague
authors.forename: Chengjie
authors.initials: C
authors.lastname: Xiong
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Grant
authors.forename: Angela
authors.initials: A
authors.lastname: Campbell
authors.forename: Brian R
authors.initials: BR
authors.lastname: Ott
authors.forename: David M
authors.initials: DM
authors.lastname: Holtzman
authors.forename: Tammie L S
authors.initials: TL
authors.lastname: Benzinger
authors.forename: Anne M
authors.initials: AM
authors.lastname: Fagan
authors.forename: David B
authors.initials: DB
authors.lastname: Carr
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D000814:Aniline Compounds; D058070:Asymptomatic Diseases; D001334:Automobile Driving; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods; D013844:Thiazoles; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D015415:Biomarkers; D013844:Thiazoles; D016875:tau Proteins