title: Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid.
abstract: We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154-159.
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO.
authors.forename: Yo-El S
authors.initials: YE
authors.lastname: Ju
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO.|Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO.|Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO.
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Finn
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO.|Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO.|Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO.
authors.forename: Courtney L
authors.initials: CL
authors.lastname: Sutphen
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Herries
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO.|Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO.|Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO.
authors.forename: Gina M
authors.initials: GM
authors.lastname: Jerome
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
authors.forename: Jack H
authors.initials: JH
authors.lastname: Ladenson
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Crimmins
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO.|Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO.|Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Fagan
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO.|Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO.|Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO.
authors.forename: David M
authors.initials: DM
authors.lastname: Holtzman
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D002490:Central Nervous System / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)