title: Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.
abstract: The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Institute of Medical Virology, University of Zurich.
authors.forename: Alexandra U
authors.initials: AU
authors.lastname: Scherrer
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Institute of Medical Virology, University of Zurich.
authors.forename: Wan-Lin
authors.initials: WL
authors.lastname: Yang
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Institute of Medical Virology, University of Zurich.
authors.forename: Roger D
authors.initials: RD
authors.lastname: Kouyos
authors.affiliation: Institute of Medical Virology, University of Zurich.
authors.forename: Jürg
authors.initials: J
authors.lastname: Böni
authors.affiliation: Laboratory of Virology, Division of Infectious Diseases.
authors.forename: Sabine
authors.initials: S
authors.lastname: Yerly
authors.affiliation: Department of Biomedicine, University of Basel.
authors.forename: Thomas
authors.initials: T
authors.lastname: Klimkait
authors.affiliation: Division of Immunology and Allergy.
authors.forename: Vincent
authors.initials: V
authors.lastname: Aubert
authors.affiliation: Division of Infectious Diseases, University Hospital Lausanne.
authors.forename: Matthias
authors.initials: M
authors.lastname: Cavassini
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel.
authors.forename: Manuel
authors.initials: M
authors.lastname: Battegay
authors.affiliation: Department of Infectious Diseases, Berne University Hospital, University of Berne.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hauser
authors.affiliation: HIV/AIDS Unit, Infectious Disease Service, Geneva University Hospital.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Calmy
authors.affiliation: Division of Infectious Diseases, Cantonal Hospital St. Gallen.
authors.forename: Patrick
authors.initials: P
authors.lastname: Schmid
authors.affiliation: Division of Infectious Diseases, Regional Hospital Lugano, Switzerland.
authors.forename: Enos
authors.initials: E
authors.lastname: Bernasconi
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Institute of Medical Virology, University of Zurich.
authors.forename: Huldrych F
authors.initials: HF
authors.lastname: Günthard
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D015331:Cohort Studies; D018562:Disease Transmission, Infectious; D024882:Drug Resistance, Viral; D004363:Drug Utilization; D006678:HIV / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D019427:HIV Integrase / Q000235:genetics*; D019428:HIV Integrase Inhibitors / Q000627:therapeutic use; D006801:Humans; D015995:Prevalence; D013557:Switzerland / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents; D019428:HIV Integrase Inhibitors; D019427:HIV Integrase
keywords: HIV-1 drug resistance; integrase; population viral load; prevalence; transmission of drug resistance