title: YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: "Hippo-thetical", new therapeutic targets?
abstract: The Hippo-YAP signaling pathway has been established as a crucial regulator of tissue growth and tumorigenesis but the mechanism for transcriptional control remains unclear. In their study, Galli et al. show that YAP/TAZ binding is restricted to a small number of gene enhancers and that YAP/TAZ regulates transcriptional elongation by recruiting the Mediator complex.
authors.affiliation: a Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
authors.forename: Fiorina
authors.initials: F
authors.lastname: Kyritsi
authors.affiliation: a Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Price
authors.affiliation: a Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Figg
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D042863:Cyclin-Dependent Kinase 9 / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; C467969:CDK9 protein, human; D042863:Cyclin-Dependent Kinase 9
keywords: Hippo/YAP pathway; YAP-bound regulatory elements; mediator complex; transcriptional elongation; tumorigenesis