title: The emerging role of miR-223 as novel potential diagnostic and therapeutic target for inflammatory disorders.
abstract: Since their discovery of more than a decade ago, microRNAs have been demonstrated to have profound effects on almost every aspect of biology. Specific microRNAs have emerged as key players in disease biology by playing crucial role in disease development and progression. This review draws attention to miR-223 that has been reported to be abnormally expressed in several diseases like diabetes-type2, sepsis, rheumatoid arthritis, viral infections likes' human immunodeficiency virus-1 (HIV-1) and inflammatory disorders. It regulates inflammation by targeting different targets, including cytoplasmic activation/proliferation-associated protein-1 (Caprin-1), Insulin-like growth factor-1 receptor (IGF-1R), heat shock protein 90 (Hsp90), STAT5, artemin, EPB41L3, Ect2, Pknox1, C/EBPα, C/EBPβ, E2F1, FOXO1, NFI-A and other transcription factors. In this review, we summarized the recent studies of miR-223, their mechanisms to develop inflammation diseases and its importance role to use as biomarkers for early diagnosis and therapeutic target against inflammation diseases.
authors.affiliation: Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian, PR China; Immunology and Infectious Diseases Research Laboratory, Department of Microbiology, University of Karachi, Karachi, Pakistan. Electronic address: faziz@hci-cn.org.
authors.forename: Faisal
authors.initials: F
authors.lastname: Aziz
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D000071161:Forkhead Box Protein O1 / Q000235:genetics / Q000378:metabolism; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism; D050799:STAT5 Transcription Factor / Q000235:genetics / Q000378:metabolism; D018805:Sepsis / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D015415:Biomarkers; D018797:Cell Cycle Proteins; D000071161:Forkhead Box Protein O1; D018841:HSP90 Heat-Shock Proteins; D035683:MicroRNAs; D017526:Receptor, IGF Type 1; D050799:STAT5 Transcription Factor; C486562:CAPRIN1 protein, human; C525067:MIR223, human
keywords: Biomarker; Circulating miRNA; Hematopoiesis; Inflammation; Inflammatory disorders; miR-223