title: Massive chest wall resection and reconstruction for malignant disease.
abstract: OBJECTIVE
  Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histology, extent of resection, type of reconstruction, and adjuvant treatment with short- and long-term outcomes.
  
  
  METHODS
  Twenty patients were submitted to chest wall resection and reconstruction for malignant chest wall neoplasms between 2006 and 2014. The mean age (ten males) was 59±4 years. The size and histology of the tumor, the technique of reconstruction, and the short- and long-term follow-up records were noted.
  
  
  RESULTS
  The median maximum diameter of tumors was 10 cm (5.4-32 cm). Subtotal sternal resection was performed in nine cases, and the resection of multiple ribs was performed in eleven cases. The median area of chest wall defect was 108 cm(2) (60-340 cm(2)). Histology revealed soft tissue, bone, and cartilage sarcomas in 16 cases (80%), most of them chondrosarcomas. The rest of the tumors was metastatic tumors in two cases and localized malignant pleural mesothelioma and non-Hodgkin lymphoma in one case. The chest wall defect was reconstructed by using the "sandwich technique" (propylene mesh/methyl methacrylate/propylene mesh) in nine cases of large anterior defects or by using a 2 mm polytetrafluoroethylene (e-PTFE) mesh in nine cases of lateral or posterior defects. Support from a plastic surgeon was necessary to cover the full-thickness chest wall defects in seven cases. Adjuvant oncologic treatment was administered in 13 patients. Local recurrences were observed in five cases where surgical reintervention was finally necessary in two cases. Recurrences were associated with larger tumors, histology of malignant fibrous histiocytoma, and initial incomplete resection or misdiagnosis made by nonthoracic surgeons. Three patients died during the study period because of recurrent disease or complications of treatment for recurrent disease.
  
  
  CONCLUSIONS
  Chest wall tumors are in their majority mesenchymal neoplasms, which often require major chest wall resection for their eradication. Long-term survival is expected in low-grade tumors where a radical resection is achieved, while big tumors and histology of malignant fibrous histiocytoma are connected with the increase rate of recurrence.
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Christophoros N
authors.initials: CN
authors.lastname: Foroulis
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Athanassios D
authors.initials: AD
authors.lastname: Kleontas
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Tagarakis
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Chryssoula
authors.initials: C
authors.lastname: Nana
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Alexiou
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Vasilis
authors.initials: V
authors.lastname: Grosomanidis
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Paschalis
authors.initials: P
authors.lastname: Tossios
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Elena
authors.initials: E
authors.lastname: Papadaki
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kioumis
authors.affiliation: Oncology Department, European Interbalkan Medical Center, Thessaloniki, Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Baka
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Paul
authors.initials: P
authors.lastname: Zarogoulidis
authors.affiliation: Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Anastasiadis
keywords: chest wall reconstruction; chest wall resection; chest wall tumors; chondrosarcoma; soft tissue sarcomas; sternal tumors