title: The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway.
abstract: The RASopathies are a group of disorders due to variations of genes associated with the Ras/MAPK pathway. Some of the RASopathies include neurofibromatosis type 1 (NF1), Noonan syndrome, Noonan syndrome with multiple lentigines, cardiofaciocutaneous (CFC) syndrome, Costello syndrome, Legius syndrome, and capillary malformation-arteriovenous malformation (CM-AVM) syndrome. In combination, the RASopathies are a frequent group of genetic disorders. This report summarizes the proceedings of the 4th International Symposium on Genetic Disorders of the Ras/MAPK pathway and highlights gaps in the field. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Stanford University, Stanford, California.
authors.forename: David A
authors.initials: DA
authors.lastname: Stevenson
authors.affiliation: RASopathies Network, California.
authors.forename: Lisa
authors.initials: L
authors.lastname: Schill
authors.affiliation: RASopathies Network, California.
authors.forename: Lisa
authors.initials: L
authors.lastname: Schoyer
authors.affiliation: University of Southern Denmark, Odense, Denmark.
authors.forename: Brage S
authors.initials: BS
authors.lastname: Andresen
authors.affiliation: Children's Tumor Foundation, New York, New York.
authors.forename: Annette
authors.initials: A
authors.lastname: Bakker
authors.affiliation: Department of Pathology, University of Utah, Salt Lake City, Utah.
authors.forename: Pinar
authors.initials: P
authors.lastname: Bayrak-Toydemir
authors.affiliation: University of Manchester, United Kingdom.
authors.forename: Emma
authors.initials: E
authors.lastname: Burkitt-Wright
authors.affiliation: University of Colorado, Denver, Colorado.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Chatfield
authors.affiliation: Baylor College of Medicine, Houston, Texas.
authors.forename: Florent
authors.initials: F
authors.lastname: Elefteriou
authors.affiliation: Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Ype
authors.initials: Y
authors.lastname: Elgersma
authors.affiliation: Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Fisher
authors.affiliation: University of Cincinnati, Cincinnati, Ohio.
authors.forename: David
authors.initials: D
authors.lastname: Franz
authors.affiliation: Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Gelb
authors.affiliation: University of Oxford, Oxford, United Kingdom.
authors.forename: Anne
authors.initials: A
authors.lastname: Goriely
authors.affiliation: Division of Medical Genetics, A. I. duPont Hospital for Children, Wilmington, Delaware.
authors.forename: Karen W
authors.initials: KW
authors.lastname: Gripp
authors.affiliation: Stanford University, Stanford, California.
authors.forename: Antonio Y
authors.initials: AY
authors.lastname: Hardan
authors.affiliation: National Human Genome Research Institute, NIH, Bethesda, Maryland.
authors.forename: Kim M
authors.initials: KM
authors.lastname: Keppler-Noreuil
authors.affiliation: University of Manchester, United Kingdom.
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Kerr
authors.affiliation: University of Alabama-Birmingham, Alabama.
authors.forename: Bruce
authors.initials: B
authors.lastname: Korf
authors.affiliation: Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Leoni
authors.affiliation: National Cancer Institute, NIH, Bethesda, Maryland.
authors.forename: Frank
authors.initials: F
authors.lastname: McCormick
authors.affiliation: Massachussets General Hospital, Boston, Massachusetts.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Plotkin
authors.affiliation: Division of Genomic Medicine, Department of Pediatrics, UC Davis, Sacramento, California.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Rauen
authors.affiliation: National Cancer Institute, NIH, Bethesda, Maryland.
authors.forename: Karlyne
authors.initials: K
authors.lastname: Reilly
authors.affiliation: Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Amy
authors.initials: A
authors.lastname: Roberts
authors.affiliation: National Cancer Institute, NIH, Bethesda, Maryland.
authors.forename: Abby
authors.initials: A
authors.lastname: Sandler
authors.affiliation: Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Dawn
authors.initials: D
authors.lastname: Siegel
authors.affiliation: George Washington University Medical School, Washington, District of Columbia.
authors.forename: Karin
authors.initials: K
authors.lastname: Walsh
authors.affiliation: National Cancer Institute, NIH, Bethesda, Maryland.
authors.forename: Brigitte C
authors.initials: BC
authors.lastname: Widemann
mesh_terms: D002202:Capital Financing; D002986:Clinical Trials as Topic; D005190:Family; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D000070516:Intersectoral Collaboration; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D020928:Mitogen-Activated Protein Kinases; D018631:ras Proteins
keywords: RASopathy; Ras/MAPK; cancer; clinical trials; experimental models; rare disorders