title: [DEVELOPMENT OF THE QUADRIVALENT LIVE ATTENUATED INFLUENZA VACCINE INCLUDING TWO INFLUENZA B LINEAGES--VICTORIA AND YAMAGATA].
abstract: This work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. The intranasal immunization of the CBA mice with both Victoria and Yamagata strains induced 100% lung protection against the subsequent infection with the wild-type influenza B viruses of any antigen lineage. The quadrivalent LAIV (qLAIV) comprising both reassortant influenza B viruses Victoria and Yamagata were safe and areactogenic in adult volunteers. Following qLAIV administration the immune response was achieved to both Victoria and Yamagata lineages.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Desheva
authors.forename: T A
authors.initials: TA
authors.lastname: Smolonogina
authors.forename: E M
authors.initials: EM
authors.lastname: Doroshenko
authors.forename: L G
authors.initials: LG
authors.lastname: Rudenko
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects*; D009981:Influenza B virus / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000096:biosynthesis / Q000276:immunology; D007251:Influenza, Human / Q000097:blood / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008875:Middle Aged; D016865:Reassortant Viruses / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit