title: Correlation of the system of cytokines in moderate and severe preeclampsia.
abstract: OBJECTIVE
  To study the production of pro-inflammatory (IL-1β, IL- 2, IL-6, IL-8) and anti-inflammatory (IL-4, IL-10) cytokines in pregnancy complicated by preeclampsia in the third trimester. Institution: University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia.
  
  
  METHODS
  Fifty women with pregnancies complicated by preeclampsia in the third trimester and 50 women with physiological pregnancy. Levels of IL-1β, IL-2, IL-6, IL-8, IL-4, and IL-10 were measured by using a solid-phase enzyme immunoassay. Statistical data processing was done using the application program SPSS for Windows 13.0. To describe the distribution of analyzed variables, descriptive methods (mean, median, minim and max) were used .
  
  
  RESULTS
  In pregnancies complicated by preeclampsia, there are increased levels of proinflammatory cytokines and a change in the behaviour of opposing pools. Most pronounced changes in the levels of proinflammatory cytokines were observed in mild preeclampsia. In severe preeclampsia there was reduction of the concentration of anti-inflammatory cytokines IL-4 and IL-10.
  
  
  CONCLUSIONS
  The use of assessment cytokine profile monitoring of health status of women with preeclampsia is expedient.
authors.forename: A Markova
authors.initials: AM
authors.lastname: Daneva
authors.forename: M
authors.initials: M
authors.lastname: Hadži-Lega
authors.forename: M
authors.initials: M
authors.lastname: Stefanovic
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000276:immunology*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012720:Severity of Illness Index
chemical_list: C508606:CXCL8 protein, human; D016207:Cytokines; C508609:IL10 protein, human; C508585:IL1B protein, human; C508594:IL2 protein, human; C508598:IL4 protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D015847:Interleukin-4