title: A retrospective look at anthranilic diamide insecticides: discovery and lead optimization to chlorantraniliprole and cyantraniliprole.
abstract: Anthranilic diamides are an important commercial synthetic class of insecticides (IRAC Group 28) that bind to the ryanodine receptor with selective potency against insect versus mammalian forms of the receptor. The first commercialized diamide, chlorantraniliprole, has exceptional activity against lepidopteran pests. The second anthranilamide product, cyantraniliprole, has excellent cross-spectrum activity against a range of insect orders, including both lepidopteran and hemipteran pests. Here, a retrospective look is presented on the discovery of the class, along with chemistry highlights of the lead evolution to both products. © 2016 Society of Chemical Industry.
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, Newark, DE, USA.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Selby
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, Newark, DE, USA.
authors.forename: George P
authors.initials: GP
authors.lastname: Lahm
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, Newark, DE, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D006430:Hemiptera / Q000187:drug effects; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D009036:Moths / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D011720:Pyrazoles; D019837:Ryanodine Receptor Calcium Release Channel; D062367:ortho-Aminobenzoates; C517733:chlorantranilipole; C558219:cyantraniliprole
keywords: IRAC Group 28; anthranilic diamide; chlorantraniliprole; cyantraniliprole; diamide; insecticide; ryanodine receptor