title: Association study of the PLXNA4 gene with the risk of Alzheimer's disease.
abstract: BACKGROUND
  The Plexin-A 4 (PLXNA4) gene has recently been recognized as a functional candidate gene of late-onset Alzheimer's disease (LOAD). The single nucleotide polymorphism (SNP) rs13232207 of PLXNA4 gene has been reported to be associated with Alzheimer's disease (AD) in Japanese cohorts. We sought to clarify whether this novel locus gains the same effect in northern Han Chinese.
  
  
  METHODS
  To investigate the relationship between SNP rs13232207 and AD sufferers, a case-control study of unrelated individuals was conducted with a total sample size of 2,318 subjects (978 cases and 1,340 age and gender matched healthy controls) in a Northern Han Chinese population. SPSS 22.0 was applied for the statistical process.
  
  
  RESULTS
  No significant difference in polymorphic distribution of rs13232207 was observed on LOAD risk independently under dominant (P=0.057), additive (P=0.233) or recessive model (P=0.392). In terms of interaction with apolipoprotein E (APOE), there is also no positive interaction in dominant (P=0.438), additive (P=0.055) or recessive model (P=0.095).
  
  
  CONCLUSIONS
  Replication of association between the PLXNA4 rs13232207 and AD in a Han ethnic group indicates that this link is not the result of chance.
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Fu-Rong
authors.initials: FR
authors.lastname: Sun
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Tan
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Hui-Fu
authors.initials: HF
authors.lastname: Wang
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Zi-Xuan
authors.initials: ZX
authors.lastname: Wang
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Teng
authors.initials: T
authors.lastname: Jiang
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao 266000, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266000, China ; 3 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266000, China ; 4 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266000, China ; 5 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 6 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
keywords: Alzheimer’s disease (AD); Plexin-A 4 (PLXNA4); polymorphism