title: A SNARE and specific COPII requirements define ER-derived vesicles for the biogenesis of autophagosomes.
abstract: The endoplasmic reticulum (ER) is a major source for the generation of autophagosomes during macroautophagy. Our recent work in yeast shows that particular ER-derived vesicles are generated for the biogenesis of autophagosomes. These vesicles not only incorporate a SNARE protein that is largely ER-resident under nonstarving conditions, but also display COPII requirements for ER-exit that differ from conventional cargo-transporting vesicles. Our results suggest that specific intracellular traffic is launched at the ER for the transport of membranes to sites of autophagosome formation.
authors.affiliation: a Department of Genetics , University of Seville , Avda Reina Mercedes, Seville , Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Lemus
authors.affiliation: a Department of Genetics , University of Seville , Avda Reina Mercedes, Seville , Spain.
authors.forename: Veit
authors.initials: V
authors.lastname: Goder
mesh_terms: D000818:Animals; D000071182:Autophagosomes / Q000378:metabolism*; D022181:COP-Coated Vesicles / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D050600:SNARE Proteins / Q000378:metabolism*
chemical_list: D050600:SNARE Proteins
keywords: COPII; SNARE proteins; autophagy; membrane fusion; membrane traffic