title: Putative role of 5-HT2Breceptors in migraine pathophysiology.
abstract: Objective In this review we attempt to characterize the acute and chronic role of 5-HT2Breceptors with regard to meningeal nociception in animal experiments and clinical data targeting migraine therapy. Background Migraine is a common disabling neurovascular primary headache disease, the pathomechanism of which is still unclear. Serotonin (5-HT) and its receptors might play an important role in some aspects of migraine pathogenesis. The ability of the unselective 5-HT2Breceptor agonist m-chlorophenylpiperazine to induce migraine attacks in migraine sufferers, the high affinity of prophylactic antimigraine drugs to this receptor and its expression in migraine-relevant structures like the dura mater argue for a role of 5-HT2Breceptors in the pathogenesis of migraine attacks. Methods For this review, the relevant databases such as PubMed, MEDLINE®, Cochrane Library and EMBASE, respectively, were searched to December 2015 using the keywords "migraine, 5-HT2, trigeminal, neurogenic inflammation, nitric oxide, nitroxyl, vasodilatation, plasma protein extravasation" and combinations thereof. Conclusion Our literature review suggests an important role of 5-HT2Breceptor activation in meningeal nociception and the generation of migraine pain.
authors.affiliation: 1 Department for Anesthesiology, Operative Intensive Care and Pain Medicine, University Hospital Muenster, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Segelcke
authors.affiliation: 2 Institute of Physiology and Pathophysiology, Friedrich Alexander University Erlangen-Nuernberg, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Messlinger
mesh_terms: D000818:Animals; D006801:Humans; D008881:Migraine Disorders / Q000378:metabolism / Q000503:physiopathology*; D010146:Pain / Q000378:metabolism / Q000503:physiopathology*; D044403:Receptor, Serotonin, 5-HT2B / Q000378:metabolism*
chemical_list: D044403:Receptor, Serotonin, 5-HT2B
keywords: 5-HT2B receptor; CGRP; NO dependent; plasma protein extravasation; vasodilatation