title: What Are the Risk Factors for Lymphocyst Formation Apart From Lymphnode Dissection and Lymphnode Count in Gynecologic Malignancy?
abstract: Aim:Lymphocyst is one of the most common complications of lymphadenectomy and generally encountered during uro-gynecological oncology surgeries. We aimed to define the risk factors for formation of a lymphocyst in patients with various gynecological cancer types in whom a lymphadenectomy was performed.Methods:This retrospective study was performed on 206 patients. Of the 206 patients, 100 were diagnosed with a lymphocyst, and 106 were assigned to a control group. Laboratory findings and surgical characteristics of the patients were compared.Results:No differences were observed in age, pre-operative hemoglobin; platelet, white blood cell, and lymphocyte counts; or pre-operative albumin level (p = 0.315, 0.500, 0.525, 0.683, 0.740, and 0.97, respectively). A significant effect of the heparin dose × heparin days interaction and lymphocyst formation was observed (p = 0.002). Lymphocysts were most frequently detected in the ovarian cancer subgroup (49 %). Significant differences were detected between the groups in the percentages of patients who underwent CT only and RT only treatments (p = 0.001 and 0.002, respectively). The logistic regression analysis revealed a relationship between the LMWH dose × days interaction and formation of a lymphocyst (OR, 1.10; 95 % CI, 1.0-1.13; p = 0.01).Conclusion:The association between total LMWH dose administered and the formation of lymphocysts in patients with gynecological pelvic cancer was investigated for the first time. Significant relationship between heparin dose × days and lymphocyst formation was found. Although anticoagulation with LMWH is essential for preventing thromboembolism, it should be used appropriately to prevent other complications, such as bleeding and lymphocysts.
authors.affiliation: Zonguldak Bulent Ecevit University School of Medicine, Department of Obstetrics and Gynecology, Zonguldak, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Sahbaz
authors.affiliation: Izmir Tepecik Research and Training Hospital, Department of Gynecology and Oncology, Izmir, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Gungorduk
authors.affiliation: Izmir Tepecik Research and Training Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Gulseren
authors.affiliation: Bakirkoy Sadi Konuk Research and Training Hospital, Department of Gynecology and Oncology, Istanbul, Turkey.
authors.forename: I A
authors.initials: IA
authors.lastname: Ozdemir
authors.affiliation: Zonguldak Bulent Ecevit University School of Medicine, Department of Obstetrics and Gynecology & Obstetrics and Gynecology, Zonguldak, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Harma
authors.affiliation: Zonguldak Bulent Ecevit University School of Medicine, Department of Obstetrics and Gynecology & Obstetrics and Gynecology, Zonguldak, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Harma
authors.affiliation: Izmir Tepecik Research and Training Hospital, Department of Gynecology and Oncology, Izmir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Sancı
keywords: gynecologic malignancies; lymphadenectomy; lymphocysts