title: Neuroprotection against vascular dementia after acupuncture combined with donepezil hydrochloride: P300 event related potential.
abstract: Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5 mg/day, once a day for 56 days), or combined with acupuncture at Shenting (DU24), Tianzhu (BL10), Sishencong (Extra), Yintang (Extra), Renzhong (DU26), Neiguan (PC6), Shenmen (HT7), Fengchi (GB20), Wangu (GB12) and Baihui (DU20) (once a day for 56 days). Compared with donepezil hydrochloride alone, P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture. Mini-Mental State Examination score was also higher. Moreover, these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture. These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia, and exerts neuroprotective effects against vascular dementia.
authors.affiliation: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Qiang
authors.identifier: 0000-0002-7582-8959
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Tianjin Third Central Hospital, Tianjin, China.
authors.forename: Zhe-Cheng
authors.initials: ZC
authors.lastname: Zhang
authors.affiliation: General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xue
authors.affiliation: Tianjin Quanjian International Cancer Hospital, Tianjin, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
keywords: acupuncture; cognitive function; donepezil hydrochloride; event related potential; infarct focus; nerve regeneration; neural regeneration; vascular dementia