title: Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity.
abstract: Glycolytic activity in T cells governs T cell responses by controlling various cellular processes, including proliferation, survival, and effector functions. We recently showed that the tumor microenvironment diminishes T cell antitumor responses by depriving glucose to infiltrating T cells. Moreover, metabolic rewiring tumor-reactive T cells sustain T cell metabolic fitness and antitumor responses.
authors.affiliation: Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Center for Cancer Research at University of Lausanne, Lausanne, Switzerland.
authors.forename: Wan-Chen
authors.initials: WC
authors.lastname: Cheng
authors.affiliation: Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Center for Cancer Research at University of Lausanne, Lausanne, Switzerland.
authors.forename: Ping-Chih
authors.initials: PC
authors.lastname: Ho
keywords: Immunotherapy; PEP; immune checkpoint; metabolic reprogramming; tumor infiltrating T cell