title: Linear scleroderma with prominent multiple lymphadenopathy followed by the development of polymyositis: A case report and review of published work.
abstract: Localized scleroderma is an inflammatory disorder affecting the skin and underlying tissues, a certain subset of which develops other autoimmune diseases on the basis of a prominent autoimmune background. We here report a unique case of linear scleroderma presenting with a sclerotic plaque on the left thigh, multiple lymphadenopathy in bilateral inguinal and para-aortic lymph nodes, and hepatosplenomegaly, who later developed polymyositis. We describe the detailed disease course of our case and discuss the clinical significance of multiple lymphadenopathy in localized scleroderma based on a review of published work.
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. yasano-tky@umin.ac.jp.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Hirakawa
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Saigusa
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Aozasa
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Hayakazu
authors.initials: H
authors.lastname: Sumida
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujita
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.affiliation: Department of Neurology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Ohmori
authors.affiliation: Department of Neurology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shimizu
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D002502:Centrioles / Q000276:immunology; D004576:Electromyography; D005205:Fascia / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006529:Hepatomegaly / Q000000981:diagnostic imaging / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D000072281:Lymphadenopathy / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008209:Lymphedema / Q000000981:diagnostic imaging / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000201:enzymology / Q000473:pathology; D017285:Polymyositis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D005938:Glucocorticoids; D011239:Prednisolone
keywords: hepatosplenomegaly; immune abnormality; linear scleroderma; lymphadenopathy; polymyositis