title: Preoperative detection of hepatic metastases from colorectal cancer: Prospective comparison of contrast-enhanced ultrasound and multidetector-row computed tomography (MDCT).
abstract: OBJECTIVE
  The goal of this study was to prospectively compare the sensitivity of contrast-enhanced ultrasound (CEUS) with that of multiphase multidetector-row computed tomography (MDCT) in the preoperative detection of hepatic metastases.
  
  
  METHODS
  Forty-eight patients, with a mean age of 62years old (range: 43-85years) were prospectively included. All patients underwent CEUS following intravenous administration of 2.4mL of an ultrasound contrast agent (Sonovue(®), Bracco, Milan, Italy) and multiphase MDCT. Intraoperative ultrasound examination (IOUS) was used as the standard of reference.
  
  
  RESULTS
  A total of 158 liver metastases were identified by IOUS, 127 by preoperative MDCT (sensitivity; 80.4%) and 102 by CEUS (sensitivity, 64.5%). The 15.9% difference in sensitivity between CEUS and MDCT was statistically significant (P=0.002). There was a disagreement between IOUS and CEUS in 23 patients (47%) and in 13 patients (27%) between IOUS and MDCT. MDCT identified one or more additional metastases in 10 patients (20%) resulting in a change in the surgical strategy.
  
  
  CONCLUSIONS
  Based on an unselected patient cohort and using multiphase MDCT, CEUS is significantly inferior to MDCT for the preoperative detection of hepatic metastases of colorectal cancer.
authors.affiliation: Service de radiologie, CHU de la Milétrie, rue de la Milétrie, 86000 Poitiers, France; Cabinet de radiologie, 2, chemin Fregeneuil, 16025 Angoulême cedex, France. Electronic address: jean-pierre.tasu@neuf.fr.
authors.forename: R
authors.initials: R
authors.lastname: Vialle
authors.affiliation: Service de radiologie, CHU de la Milétrie, rue de la Milétrie, 86000 Poitiers, France.
authors.forename: S
authors.initials: S
authors.lastname: Boucebci
authors.affiliation: Service de chirurgie viscérale, CHU de la Milétrie, rue de la Milétrie, 86000 Poitiers, France; Laboratoire d'anatomie et de simulation, université de Poitiers, rue de la Milétrie, 86000 Poitiers, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Richer
authors.affiliation: Service de radiologie, CHU de la Milétrie, rue de la Milétrie, 86000 Poitiers, France.
authors.forename: S
authors.initials: S
authors.lastname: Velasco
authors.affiliation: Service de radiologie, CHU de la Milétrie, rue de la Milétrie, 86000 Poitiers, France.
authors.forename: G
authors.initials: G
authors.lastname: Herpe
authors.affiliation: Service de radiologie, CHU de la Milétrie, rue de la Milétrie, 86000 Poitiers, France.
authors.forename: G
authors.initials: G
authors.lastname: Vesselle
authors.affiliation: Unité de biostatistique et d'épidémologie clinique, CIC 1402, université de Poitiers, 86000 Poitiers, France.
authors.forename: P
authors.initials: P
authors.lastname: Ingrand
authors.affiliation: Service de radiologie, CHU de la Milétrie, rue de la Milétrie, 86000 Poitiers, France; DACTIM, équipe émergeante en imagerie, université de Poitiers, rue de la Milétrie, 86000 Poitiers, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Tasu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D057234:Preoperative Period; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D003287:Contrast Media
keywords: Comparative studies; Computed tomography; Contrast-enhanced ultrasound examination; Liver metastasis