title: Trends in Laboratory Diagnostic Methods in Periodontology.
abstract: This work presents a summary of current knowledge on the laboratory diagnosis of periodontitis. It focuses on the theoretical foundations and is supplemented with new knowledge. It subsequently describes specifically the laboratory diagnosis methods of periodontitis: the protein expression of inflammation, oral microbiology and molecular diagnostics. Periodontitis is a serious disease worldwide and its confirmed association with systemic diseases means its severity is increasing. Its laboratory diagnosis has the potential to rise to the level of clinical and diagnostic imaging. The transfer of diagnostic methods from laboratory to clinical use is increasingly used in the prevention and monitoring of the exacerbation and treatment of periodontal disease, as well as of its impact on systemic disease.
authors.affiliation: Department of Medical and Clinical Biochemistry, Faculty of Medicine, P. J. Šafárik University in Košice, Košice, Slovakia. beata@moly.sk.
authors.forename: Beáta
authors.initials: B
authors.lastname: Bolerázska
authors.affiliation: Department of Medical and Clinical Biochemistry, Faculty of Medicine, P. J. Šafárik University in Košice, Košice, Slovakia.
authors.forename: Mária
authors.initials: M
authors.lastname: Mareková
authors.affiliation: 1st Department of Stomatology, Louis Pasteur University Hospital, Košice, Slovakia.
authors.forename: Neda
authors.initials: N
authors.lastname: Markovská
mesh_terms: D015415:Biomarkers; D003774:Dental Plaque Index; D003937:Diagnosis, Differential; D005883:Gingival Crevicular Fluid / Q000382:microbiology; D006801:Humans; D010512:Periodontal Index; D010518:Periodontitis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control* / Q000628:therapy; D010519:Periodontium / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D015995:Prevalence; D012720:Severity of Illness Index; D018154:Slovakia / Q000453:epidemiology
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Diagnosis; Gingival crevicular fluid; Markers of bone remodelling; Periodontitis; Point-of care testing; Saliva