title: Paraoxonase Activity and Oxidative Status in Patients with Tinnitus.
abstract: OBJECTIVE
  The aim of this study was to investigate serum paraoxanase-1 (PON) activity, total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI) in tinnitus; and to compare the results with data from healthy subjects.
  
  
  METHODS
  A total of 114 subjects-54 patients with tinnitus and 60 healthy controls were enrolled in this study. Serum PON activity, TOS, TAS, and OSI levels were measured.
  
  
  RESULTS
  In the tinnitus group, TAS, and PON were significantly lower than in the control group (p<0.001). However, the TOS, and OSI levels were significantly higher in the tinnitus group than in the control group (p<0.001).
  
  
  CONCLUSIONS
  According to the data obtained from the present study, patients with tinnitus were exposed to potent oxidative stress. Oxidative stress may be the key contributing factor to the pathogenesis of tinnitus.
authors.affiliation: Department of Otorhinolaryngology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Koç
authors.affiliation: Department of Otorhinolaryngology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Akyüz
authors.affiliation: Department of Otorhinolaryngology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
authors.forename: Battal Tahsin
authors.initials: BT
authors.lastname: Somuk
authors.affiliation: Department of Otorhinolaryngology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Soyalic
authors.affiliation: Department of Otorhinolaryngology, Dicle University School of Medicine, Diyarbakır, Turkey.
authors.forename: Beyhan
authors.initials: B
authors.lastname: Yılmaz
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Bilinc
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
keywords: Oxidative stress index; Paraoxonase; Tinnitus; Total antioxidant status; Total oxidant status