title: Determination of albumin adducts of 4,4'-methylenediphenyl diisocyanate in workers of a 4,4'-methylenedianiline factory.
abstract: Lung sensitization and asthma are the main health effects of 4,4'-methylenediphenyl diisocyanate (MDI). Albumin adducts (isocyanate specific adducts) of MDI might be involved in the etiology of sensitization reactions. Albumin adducts of MDI have been found in subjects classified as 4,4'-methylenedianiline (MDA) workers. The mean adduct levels in these MDA-workers were 1.5 times higher than in MDI-workers of the same company. MDA-specific hemoglobin adducts, were present ten times more in the MDA-workers than in the MDI-workers. MDA-workers with specific work task had significantly higher albumin adduct levels.
authors.affiliation: a Institute of Environmental and Occupational Toxicology , Airolo , Switzerland.|b Walther-Straub-Institut für Pharmakologie und Toxikologie , Ludwig-Maximilians-Universität , München , Germany.|c Department of Environmental Health Sciences, School of Public Health and Tropical Medicine , Tulane University , New Orleans , LA , USA.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sabbioni
authors.affiliation: c Department of Environmental Health Sciences, School of Public Health and Tropical Medicine , Tulane University , New Orleans , LA , USA.|d National Laboratories Inc , Detroit , MI , USA.
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Dongari
authors.affiliation: e Insitutut für Pharmakologie und Toxikologie , Julius-Maximilians-Universität Würzburg , Würzburg , Germany.
authors.forename: Ovnair
authors.initials: O
authors.lastname: Sepai
authors.affiliation: c Department of Environmental Health Sciences, School of Public Health and Tropical Medicine , Tulane University , New Orleans , LA , USA.
authors.forename: Anoop
authors.initials: A
authors.lastname: Kumar
keywords: Albumin adducts; biomonitoring; hemoglobin adducts; isocyanates