title: Short-term morbidities and neurodevelopmental outcomes in preterm infants exposed to magnesium sulphate treatment.
abstract: OBJECTIVE
  The aim of the study is to examine whether baseline serum Mg concentration has an impact on short-term and long-term outcomes in preterm infants exposed antenatally to MgSO4.
  
  
  METHODS
  Participants included all infants admitted to the neonatal intensive care unit at <32 weeks of gestational age. Infant serum Mg concentration (iMgC) was examined immediately after birth in those exposed to maternal MgSO4. Data for short-term outcomes were collected from the infants' computerised charts. Neurodevelopmental outcomes at 6-12 months corrected age were assessed using the Griffiths Mental Developmental Scales.
  
  
  RESULTS
  Of 197 eligible infants, 145 were exposed to MgSO4. Baseline iMgC was available for 88 infants. Mean iMgC was 3.5 ± 0.88 mg/dL (1.6-5.7 mg/dL). Baseline iMgC was not associated with an increased risk for neither early morbidities nor adverse long-term outcome. However, iMgC above the mean (>3.5 mg/dL) was associated with significantly lower scores on locomotor (P = 0.016) and personal-social (0.041) scales in the first year of life.
  
  
  CONCLUSIONS
  In a cohort of preterm infants antenatally exposed to MgSO4, elevated baseline iMgC (>3.5 mg/dL) was associated with lower locomotor scores. Further research is needed in order to study the relationship between supra-physiologic iMgC and its effect on the developing brain.
authors.affiliation: Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat Gan, Tel HaShomer, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Morag
authors.affiliation: Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat Gan, Tel HaShomer, Israel.
authors.forename: Daniel
authors.initials: D
authors.lastname: Yakubovich
authors.affiliation: Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat Gan, Tel HaShomer, Israel.
authors.forename: Orly
authors.initials: O
authors.lastname: Stern
authors.affiliation: Israel National Center for Trauma and Emergency Medicine, Gertner Institute for Epidemiology and Public Health Policy, Ramat Gan, Tel HaShomer, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Siman-Tov
authors.affiliation: Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat Gan, Tel HaShomer, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Schushan-Eisen
authors.affiliation: Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat Gan, Tel HaShomer, Israel.
authors.forename: Tzipi
authors.initials: T
authors.lastname: Strauss
authors.affiliation: Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Tel HaShomer, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Simchen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007234:Infant, Premature / Q000097:blood*; D007363:Intensive Care Units, Neonatal; D007557:Israel; D016014:Linear Models; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009017:Morbidity; D019957:Motor Skills Disorders / Q000209:etiology / Q000503:physiopathology; D015999:Multivariate Analysis; D065886:Neurodevelopmental Disorders / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D047928:Premature Birth / Q000517:prevention & control*; D011295:Prenatal Care / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D008278:Magnesium Sulfate
keywords: magnesium sulphate; neurodevelopment; neuroprotection; preterm infant