title: What happens to cardiovascular system behind the undetectable level of HIV viremia?
abstract: Despite the combined antiretroviral therapy has improved the length and quality of life of HIV infected patients, the survival of these patients is always decreased compared with the general population. This is the consequence of non-infectious illnesses including cardio vascular diseases. In fact large studies have indicated an increased risk of coronary atherosclerotic disease, myocardial infarction even in HIV patients on cART. In HIV infected patients several factors may contribute to the pathogenesis of cardiovascular problems: life-style, metabolic parameters, genetic predisposition, viral factors, immune activation, chronic inflammation and side effects of antiretroviral therapy. The same factors may also contribute to complicate the clinical management of these patients. Therefore, treatment of these non-infectious illnesses in HIV infected population is an emerging challenge for physicians. The purpose of this review is to focus on the new insights in non AIDS-related cardiovascular diseases in patients with suppressed HIV viremia.
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: d'Ettorre
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Ceccarelli
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Pavone
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Vittozzi
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: De Girolamo
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Ivan
authors.initials: I
authors.lastname: Schietroma
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Serafino
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Noemi
authors.initials: N
authors.lastname: Giustini
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Vullo
mesh_terms: D000375:Aging; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D012307:Risk Factors; D014766:Viremia / Q000150:complications / Q000188:drug therapy
chemical_list: D019380:Anti-HIV Agents
keywords: Cardiovascular diseases; HIV; Premature aging; cARV