title: Endocytosis and Endosomal Trafficking in Plants.
abstract: Endocytosis and endosomal trafficking are essential processes in cells that control the dynamics and turnover of plasma membrane proteins, such as receptors, transporters, and cell wall biosynthetic enzymes. Plasma membrane proteins (cargo) are internalized by endocytosis through clathrin-dependent or clathrin-independent mechanism and delivered to early endosomes. From the endosomes, cargo proteins are recycled back to the plasma membrane via different pathways, which rely on small GTPases and the retromer complex. Proteins that are targeted for degradation through ubiquitination are sorted into endosomal vesicles by the ESCRT (endosomal sorting complex required for transport) machinery for degradation in the vacuole. Endocytic and endosomal trafficking regulates many cellular, developmental, and physiological processes, including cellular polarization, hormone transport, metal ion homeostasis, cytokinesis, pathogen responses, and development. In this review, we discuss the mechanisms that mediate the recognition and sorting of endocytic and endosomal cargos, the vesiculation processes that mediate their trafficking, and their connection to cellular and physiological responses in plants.
authors.affiliation: Department of Botany.|R.M. Bock Laboratories of Cell and Molecular Biology, and.
authors.forename: Julio
authors.initials: J
authors.lastname: Paez Valencia
authors.affiliation: Department of Botany.|R.M. Bock Laboratories of Cell and Molecular Biology, and.
authors.forename: Kaija
authors.initials: K
authors.lastname: Goodman
authors.affiliation: Department of Botany.|R.M. Bock Laboratories of Cell and Molecular Biology, and.|Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706; email: paezvalencia@wisc.edu , kjgoodman@wisc.edu , otegui@wisc.edu.
authors.forename: Marisa S
authors.initials: MS
authors.lastname: Otegui
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis; D011992:Endosomes; D018521:Plant Physiological Phenomena; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*; D021381:Protein Transport; D014617:Vacuoles / Q000378:metabolism
chemical_list: D010940:Plant Proteins
keywords: ESCRT; clathrin; endosomes; retromer; ubiquitin