title: Tubulointerstitial nephritis and Fanconi syndrome in a patient with primary Sjögren's syndrome accompanied by antimitochondrial antibodies: A case report and review of the literature.
abstract: We describe a 53-year-old woman with primary Sjögren's syndrome and tubulointerstitial nephritis showing distal renal tubular acidosis and Fanconi syndrome. The patient showed high serum IgM levels and positivity for antimitochondrial antibodies, although her liver function was in normal range. According to our literature review, 75% of patients with tubulointerstitial nephritis who were positive for antimitochondrial antibodies showed Fanconi syndrome, suggesting that these antibodies may directly be associated with the pathophysiology of Fanconi syndrome.
authors.affiliation: a Department of Internal Medicine , Nagaoka Red Cross Hospital , Nagaoka , Niigata , Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Saeki
authors.affiliation: a Department of Internal Medicine , Nagaoka Red Cross Hospital , Nagaoka , Niigata , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nakajima
authors.affiliation: a Department of Internal Medicine , Nagaoka Red Cross Hospital , Nagaoka , Niigata , Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ito
authors.affiliation: b Department of Internal Medicine , Nagaoka Chuo General Hospital, Nagaoka, Japan , and.
authors.forename: Takuma
authors.initials: T
authors.lastname: Takata
authors.affiliation: c Division of Clinical Nephrology and Rheumatology , Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Imai
authors.affiliation: c Division of Clinical Nephrology and Rheumatology , Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshita
authors.affiliation: a Department of Internal Medicine , Nagaoka Red Cross Hospital , Nagaoka , Niigata , Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kabasawa
authors.affiliation: a Department of Internal Medicine , Nagaoka Red Cross Hospital , Nagaoka , Niigata , Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamazaki
authors.affiliation: c Division of Clinical Nephrology and Rheumatology , Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
mesh_terms: D000141:Acidosis, Renal Tubular / Q000097:blood* / Q000150:complications / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D005198:Fanconi Syndrome / Q000097:blood* / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*; D009395:Nephritis, Interstitial / Q000097:blood* / Q000150:complications / Q000276:immunology; D012859:Sjogren's Syndrome / Q000097:blood* / Q000150:complications / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M
keywords: Antimitochondrial antibodies; Fanconi syndrome; Primary biliary cholangitis; Sjögren's syndrome; Tubulointerstitial nephritis