title: Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging.
abstract: Waldenstrom's macroglobulinaemia is the most commonly reported subtype of lymphoplasmacytic lymphoma (LPL); it is characterised by IgM secretion. Neurological complications are common usually as a result of hyperviscosity. In rare cases, cells can infiltrate the central nervous system; this is known as Bing-Neel syndrome. We report the case of a 57-year-old male with lymphoplasmacytic lymphoma of the IgG-subtype with neurological symptoms and the consequent finding of lymphoplasmacytoid cells in his cerebrospinal fluid as well as deposits on MRI and PET-CT imaging. This is the first report of Bing-Neel syndrome in IgG-subtype LPL. We discuss the biological and radiological markers of his disease, including PET imaging, which has been minimal in this area to date.
authors.affiliation: Whipps Cross Hospital, London E11 1NR, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Halperin
authors.affiliation: St Bartholomew's Hospital, London EC1A 7BE, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Hallam
authors.affiliation: St Bartholomew's Hospital, London EC1A 7BE, UK.
authors.forename: Athar
authors.initials: A
authors.lastname: Haroon
authors.affiliation: Royal London Hospital, London E1 1BB, UK.
authors.forename: Tom
authors.initials: T
authors.lastname: Butler
authors.affiliation: St Bartholomew's Hospital, London EC1A 7BE, UK.
authors.forename: Samir
authors.initials: S
authors.lastname: Agrawal