title: Association Between Serum Levels of Vitamin D and the Risk of Post-Stroke Anxiety.
abstract: Low levels of serum vitamin D are common in patients with mood disorders and stroke. It has been shown that low levels of serum vitamin D indicate a risk of depression in post-stroke subjects. Our aim was to determine the relationship between vitamin D and post-stroke anxiety (PSA).A consecutive series of 226 first acute ischemic stroke patients were recruited and followed up for 1 month. Serum levels of vitamin D were measured within 24 hours of admission. Patients with significant clinical symptoms of anxiety and a Hamilton anxiety scale score >7 were diagnosed as having PSA. In addition, 100 healthy subjects were recruited as controls and underwent measurements of serum vitamin D.A total of 60 patients (26.55%) showed anxiety at 1 month. Both PSA patients and non-PSA patients had lower serum levels of vitamin D than healthy subjects. A significant relationship was found between PSA and serum levels of vitamin D. Low serum levels of vitamin D (≤38.48 nmol/L) were independently associated with the development of PSA (OR: 2.49, 95% CI: 1.21-5.13, P = 0.01).Serum vitamin D status is related to the occurrence of anxiety in post-stroke patients and may be an independent risk factor of PSA after 1 month.
authors.affiliation: From the Department of Neurology (CW, WR, JC, BZ, QJ, LW, CC, LZ, YC, YG, JZ, DL, BS, JH), The First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, Ruian People's Hospital, Wenzhou (SZ), People's Republic of China.
authors.forename: Chaowen
authors.initials: C
authors.lastname: Wu
authors.forename: Wenwei
authors.initials: W
authors.lastname: Ren
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cheng
authors.forename: Beilei
authors.initials: B
authors.lastname: Zhu
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Jin
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.forename: Cao
authors.initials: C
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Yaling
authors.initials: Y
authors.lastname: Chang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Gu
authors.forename: Jiyun
authors.initials: J
authors.lastname: Zhao
authors.forename: Dezhao
authors.initials: D
authors.lastname: Lv
authors.forename: Bei
authors.initials: B
authors.lastname: Shao
authors.forename: Shunkai
authors.initials: S
authors.lastname: Zhang
authors.forename: Jincai
authors.initials: J
authors.lastname: He
mesh_terms: D001007:Anxiety / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood / Q000150:complications / Q000523:psychology*; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*; D014815:Vitamins / Q000097:blood*
chemical_list: D014815:Vitamins; D014807:Vitamin D