title: Study of glomerulonephritis evolution in Castilla-La Mancha (GLOMANCHA) between 1994 and 2008.
abstract: BACKGROUND
  Renal biopsy registries allow histopathological data to be collected to improve knowledge of different pathologies and their natural history.
  
  
  OBJECTIVE
  To analyse the data of the Castilla La Mancha Glomerulonephritis Registry (GLOMANCHA) and the evolution of the different biopsy-proven pathologies between 1994 and 2008.
  
  
  METHODS
  The 6 most common biopsy-proven pathologies were collected during the 14 years of the study (941 biopsies) in the 5 participant centres of the autonomous community. In 2008, we assessed patient renal survival and mortality and we evaluated associated factors to each situation for each pathology.
  
  
  RESULTS
  Of the 941 biopsies, 59% belonged to men, with a mean age of 48±18 years. At the time of the biopsy, the median glomerular filtration rate was 50.3 (25.5-76.3) ml/min/1,73 m(2) and median proteinuria was 3.4 (1.5-6.4) grams per day. The most common pathology were lupus nephropathy, followed by focal segmental glomerulosclerosis and membranous nephropathy. Lupus nephropathy and minimal change disease achieved the best renal prognosis during follow-up (mean 7.3±4.8 years). Rapidly progressive glomerulonephritis type 3 and focal segmental glomerulosclerosis had the worst renal prognosis. In addition, rapidly progressive glomerulonephritis type 3 presented the worst vital prognosis.
  
  
  CONCLUSIONS
  In GLOMANCHA, we demonstrate the poor prognosis of rapidly progressive glomerulonephritis type 3, in contrast to minimal change disease or lupus nephropathy. Renal function is an independent predictor of renal survival and mortality in this study.
authors.affiliation: Servicio de Nefrología, Complejo Hospitalario de Toledo, Toledo, España.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Conde Olasagasti
authors.affiliation: Servicio de Nefrología, Complejo Hospitalario de Toledo, Toledo, España.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Acevedo Ribó
authors.affiliation: Servicio de Nefrología, Complejo Hospitalario de Toledo, Toledo, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Roca Muñoz
authors.affiliation: Servicio de Nefrología, Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vozmediano Poyatos
authors.affiliation: Servicio de Nefrología, Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Rivera
authors.affiliation: Servicio de Nefrología, Complejo Hospitalario Universitario de Albacete, Albacete, España.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Illescas Fernández-Bermejo
authors.affiliation: Servicio de Nefrología, Complejo Hospitalario Universitario de Albacete, Albacete, España.
authors.forename: Esperanza
authors.initials: E
authors.lastname: López Rubio
authors.affiliation: Servicio de Nefrología, Hospital Virgen de la Luz, Cuenca, España.
authors.forename: Javier
authors.initials: J
authors.lastname: Usón Carrasco
authors.affiliation: Servicio de Nefrología, Hospital Universitario de Guadalajara, Guadalajara, España.
authors.forename: Serafín
authors.initials: S
authors.lastname: Tallón Lobo
authors.affiliation: Servicio de Nefrología, Hospital Universitario de Guadalajara, Guadalajara, España. Electronic address: borjaqg@gmail.com.
authors.forename: Borja
authors.initials: B
authors.lastname: Quiroga
authors.affiliation: Servicio de Nefrología, Hospital Universitario de Guadalajara, Guadalajara, España.
authors.forename: Gabriel
authors.initials: G
authors.lastname: de Arriba
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D013030:Spain / Q000453:epidemiology
keywords: Glomerulonefritis; Glomerulonephritis; Mortalidad; Mortality; Registro; Registry; Renal survival; Supervivencia renal