title: Epidemiology of Glomerular Disease in Southern Arizona: Review of 10-Year Renal Biopsy Data.
abstract: Glomerulonephritis stands third in terms of the etiologies for end-stage kidney disease in the USA. The aim of this study was to look at the patterns of biopsy-proven glomerulonephritis based on data from a single center.Kidney biopsy specimens of all patients above the age of 18 years, over a 10-year period, who had diagnosis of nondiabetic glomerular disease, were selected for the study.The most common histopathological diagnosis was focal and segmental glomerulosclerosis (FSGS) (22.25%, 158/710) followed by membranous nephropathy (20.28%, 144/710) and immunoglobulin (Ig)A nephropathy (19.71%, 140/710). There was male preponderance in all histological variants except IgA nephropathy, lupus nephritis, and pauci-immune glomerulonephritis. The race distribution was uneven, and all histological variants, except minimal change disease and lupus nephritis, were more commonly seen in whites. In a separate analysis of the histological pattern in Hispanics, lupus nephritis was the most common pathology (28.70%, 62/216) followed by FSGS (18.05%, 39/216). In American Indian population, the most common pathology was IgA nephropathy (33.33%, 8/24) followed by FSGS (16.67%, 4/24).This study highlights the histopathological patterns of glomerular disease in southern Arizona. The data suggest regional and ethnic variations in glomerular disease that may point towards genetic or environmental influence in the pathogenesis of glomerular diseases.
authors.affiliation: From the Department of Nephrology (SM, BB, BT, PK); and Department of Medicine (IM, MH, KH, EH, SD), University of Arizona Medical Center, Tucson, AZ.
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Murugapandian
authors.forename: Iyad
authors.initials: I
authors.lastname: Mansour
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hudeeb
authors.forename: Khaled
authors.initials: K
authors.lastname: Hamed
authors.forename: Emad
authors.initials: E
authors.lastname: Hammode
authors.forename: Babitha
authors.initials: B
authors.lastname: Bijin
authors.forename: Sepehr
authors.initials: S
authors.lastname: Daheshpour
authors.forename: Bijin
authors.initials: B
authors.lastname: Thajudeen
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kadambi
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D001130:Arizona / Q000453:epidemiology; D001706:Biopsy; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology*; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000453:epidemiology / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000453:epidemiology / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000453:epidemiology / Q000473:pathology; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D007198:Indians, North American / Q000706:statistics & numerical data; D007668:Kidney / Q000473:pathology*; D008181:Lupus Nephritis / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000453:epidemiology / Q000473:pathology; D012737:Sex Factors; D044465:White People / Q000706:statistics & numerical data