title: [MORPHOLOGICAL DIFFERENCES BETWEEN THE EFFECTS OF VARIOUS MODES OF PRECONDITIONING AIMED AT CORRECTING THE DAMAGE TO THE HIPPOCAMPAL NEURONS BY SEVERE HYPOBARIC HYPOXIA].
abstract: In 5 groups of rats (6 animals in each), the changes of neurons in hippocampal fields CA1 and CA4 were studied 7 days after severe hypobaric hypoxia (180 mm Hg, for 3 h) preceded by various numbers (1, 3 and 6) of sessions of preconditioning (PC) by mild hypobaric hypoxia (360 mm Hg, for 2 h, 24 h prior to severe hypoxia). It was found that a single session of PC did not prevent the damage to the structure of neurons and their death after exposure to severe hypoxia. Meanwhile, 6, and especially 3 sessions of PC induced protective mechanisms of neuronal damage prevention. In rats after 6 sessions of PC, unlike those exposed to 3 sessions, mild chromatolysis of hippocampal neurons was demonstrated. This could result from prolonged hypermetabolic activity of neurons and indicate their functional overloading.
authors.forename: M O
authors.initials: MO
authors.lastname: Samoilov
authors.forename: A V
authors.initials: AV
authors.lastname: Churilova
authors.forename: T S
authors.initials: TS
authors.lastname: Glushchenko
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000532:Altitude Sickness / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001274:Atmospheric Pressure; D056547:CA1 Region, Hippocampal / Q000378:metabolism / Q000648:ultrastructure*; D018891:Dentate Gyrus / Q000378:metabolism / Q000648:ultrastructure*; D006931:Hyperbaric Oxygenation / Q000379:methods*; D002534:Hypoxia, Brain / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*; D017208:Rats, Wistar