title: The expression of several reproductive hormone receptors can be modified by perfluorooctane sulfonate (PFOS) in adult male rats.
abstract: This study was undertaken to evaluate the possible role of several reproductive hormone receptors on the disruption of the hypothalamic-pituitary-testis (HPT) axis activity induced by perfluorooctane sulfonate (PFOS). The studied receptors are the gonadotropin-releasing hormone receptor (GnRHr), luteinizing hormone receptor (LHr), follicle-stimulating hormone receptor (FSHr), and the androgen receptor (Ar). Adult male rats were orally treated with 1.0; 3.0 and 6.0 mg of PFOS kg(-1) d(-1) for 28 days. In general terms, PFOS can modify the relative gene and protein expressions of these receptors in several tissues of the reproductive axis. At the testicular level, apart from the expected inhibition of both gene and protein expressions of FSHr and Ar, PFOS also stimulates the GnRHr protein and the LHr gene expression. The receptors of the main hormones involved in the HPT axis may have an important role in the disruption exerted by PFOS on this axis.
authors.affiliation: Laboratory of Toxicology, Sciences School, University of Vigo, Las Lagunas s/n, 32004 Ourense, Spain.
authors.forename: S
authors.initials: S
authors.lastname: López-Doval
authors.affiliation: Laboratory of Toxicology, Sciences School, University of Vigo, Las Lagunas s/n, 32004 Ourense, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Salgado
authors.affiliation: Laboratory of Toxicology, Sciences School, University of Vigo, Las Lagunas s/n, 32004 Ourense, Spain. Electronic address: lafuente@uvigo.es.
authors.forename: A
authors.initials: A
authors.lastname: Lafuente
mesh_terms: D017738:Alkanesulfonic Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D015153:Blotting, Western; D005466:Fluorocarbons / Q000737:chemistry / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D016133:Polymerase Chain Reaction; D051381:Rats; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D011962:Receptors, FSH / Q000235:genetics / Q000378:metabolism*; D011974:Receptors, LH / Q000235:genetics / Q000378:metabolism*; D011966:Receptors, LHRH / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000378:metabolism
chemical_list: C410798:AR protein, human; D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; C484844:GNRHR protein, human; D011944:Receptors, Androgen; D011962:Receptors, FSH; D011974:Receptors, LH; D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C076994:perfluorooctane sulfonic acid
keywords: Androgen receptor; FSH receptor; GnRH receptor; LH receptor; PFOS; Rat