title: Meroterpenoids with Antiproliferative Activity from a Hawaiian-Plant Associated Fungus Peyronellaea coffeae-arabicae FT238.
abstract: Three unusual polyketide-sesquiterpene metabolites peyronellins A-C (1-3), along with the new epoxyphomalin analog 11-dehydroxy epoxyphomalin A (4), have been isolated from the endophytic fungus Peyronellaea coffeae-arabicae FT238, which was isolated from the native Hawaiian plant Pritchardia lowreyana. The structures of compounds 1-4 were characterized based on NMR and MS spectroscopic analysis. The absolute configuration (AC) of the compounds was determined by electronic circular dichroism (ECD). Compound 4 showed antiproliferative activity with an IC50 of 0.5 μM against OVCAR3, and it also strongly inhibited Stat3 at 5 μM.
authors.affiliation: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo , 200 West Kawili Street, Hilo, Hawai'i 96720, United States.|Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawai'i 96813, United States.
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Division of Pharmacology, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Gang
authors.initials: G
authors.lastname: Ren
authors.affiliation: Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawai'i 96813, United States.
authors.forename: Bao-Jun
authors.initials: BJ
authors.lastname: Yang
authors.affiliation: Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawai'i 96813, United States.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Miklossy
authors.affiliation: Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawai'i 96813, United States.
authors.forename: James
authors.initials: J
authors.lastname: Turkson
authors.affiliation: Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawai'i 96813, United States.
authors.forename: Peiwen
authors.initials: P
authors.lastname: Fei
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Division of Pharmacology, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Ding
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Division of Pharmacology, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.affiliation: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo , 200 West Kawili Street, Hilo, Hawai'i 96720, United States.|Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawai'i 96813, United States.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D028023:Arecaceae / Q000382:microbiology*; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D060026:Endophytes / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes