title: Comparative study on in vivo response of porous calcium carbonate composite ceramic and biphasic calcium phosphate ceramic.
abstract: In a previous study, robust calcium carbonate composite ceramics (CC/PG) were prepared by using phosphate-based glass (PG) as an additive, which showed good cell response. In the present study the in vivo response of porous CC/PG was compared to that of porous biphasic calcium phosphate ceramics (BCP), using a rabbit femoral critical-size grafting model. The materials degradation and bone formation processes were evaluated by general observation, X-ray radiography, micro-computed tomography, and histological examination. The results demonstrated excellent biocompatibility and osteoconductivity, and progressive degradation of CC/PG and BCP. Although the in vitro degradation rate of CC/PG was distinctly faster than that of BCP, at 4week post-implantation, the bone generation and material degradation of CC/PG were less than those of BCP. Nevertheless, at postoperative week 8, the increment of bone formation and material degradation of CC/PG was pronouncedly larger than that of BCP. These results show that CC/PG is a potential resorbable bone graft aside from the traditional synthetic ones.
authors.affiliation: School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China. Electronic address: fphebm@126.com.
authors.forename: Fupo
authors.initials: F
authors.lastname: He
authors.affiliation: School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Ren
authors.affiliation: Department of Biomedical Engineering, School of Basic Sciences, Guangzhou Medical University, Guangzhou 510182, China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Tian
authors.affiliation: School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China.
authors.forename: Shanghua
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, School of Basic Sciences, Guangzhou Medical University, Guangzhou 510182, China. Electronic address: xmchenw@126.com.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D002119:Calcium Carbonate / Q000737:chemistry / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D005269:Femur; D006882:Hydroxyapatites / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D016062:Porosity; D011817:Rabbits
chemical_list: D018786:Bone Substitutes; D006882:Hydroxyapatites; C074950:hydroxyapatite-beta tricalcium phosphate; D002119:Calcium Carbonate
keywords: Bone formation; Bone graft; Calcium carbonate; Calcium phosphate; Degradation