title: The prognostic value of plasma nesfatin-1 concentrations in patients with traumatic brain injury.
abstract: BACKGROUND
  Nesfatin-1 is related to inflammation. Its increased circulating concentrations are associated with the severity and prognosis of subarachnoid hemorrhage. In-hospital major adverse events (IMAEs), including acute traumatic coagulopathy, progressive hemorrhagic injury and posttraumatic cerebral infarction, are correlated with mortality after traumatic brain injury (TBI). The present study was designed to investigate the changes of plasma nesfatin-1 concentrations and further assess its association with inflammation, trauma severity, in-hospital mortality and IMAEs following TBI.
  
  
  METHODS
  We measured plasma nesfatin-1 concentrations of 100 severe TBI patients and 100 controls. Progressive hemorrhagic injury and posttraumatic cerebral infarction were diagnosed based on a follow-up computerized tomography scan. Acute traumatic coagulopathy was identified according to a coagulation test.
  
  
  RESULTS
  Plasma nesfatin-1 concentrations were significantly higher in patients than in controls and associated highly with Glasgow coma scale (GCS) scores and plasma C-reactive protein concentrations. Nesfatin-1 was indicated as an independent predictor for in-hospital mortality and IMAEs. In accordance with area under receiver operating characteristic curve, its predictive value was similar to GCS scores.
  
  
  CONCLUSIONS
  Increased plasma nesfatin-1 concentrations are associated closely with inflammation, trauma severity and clinical outcomes, indicating that nesfatin-1 might be involved in inflammation and become a good prognostic biomarker following TBI.
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China. Electronic address: huauna@126.com.
authors.forename: Gang-Qun
authors.initials: GQ
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Chou
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Ji
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Luo-Xin
authors.initials: LX
authors.lastname: Lan
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Sheng
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Yang-Fang
authors.initials: YF
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China.
authors.forename: Guo-Zhong
authors.initials: GZ
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Xiao-Qiao
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Du
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Ding-Bo
authors.initials: DB
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The Hangzhou Hospital of Traditional Chinese Medicine, 453 Tiyuchang Road, Hangzhou 310007, China.
authors.forename: Zu-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000070642:Brain Injuries, Traumatic / Q000097:blood* / Q000175:diagnosis*; D002135:Calcium-Binding Proteins / Q000097:blood*; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D011379:Prognosis; D055815:Young Adult
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: Acute traumatic coagulopathy; Mortality; Nesfatin-1; Posttraumatic cerebral infarction; Progressive hemorrhagic injury; Traumatic brain injury