title: Robust and stimuli-responsive POSS hybrid PDMAEMA hydrogels for controlled drug release.
abstract: A new polyhedral oligomeric silsesquioxane (POSS) hybrid hydrogels were desinged and fabricated by introducing cationic octa-ammonium (Oa)-POSS) into chemically cross-linked cationic PDMAEMA hydrogels via in situ radical freezing polymerization. The prepared gels (shorten as OP-PD gels) show considerably improved properties through the effective incorporation and dispersion of Oa-POSS particles in gels. Comparing to the Oa-POSS-free gels, the hybrid gels own better mechanical properties with higher tensile and compressive strength. Meantime, except the decreased swelling ratio in acid condition, the OP-PD gels still keep excellent swelling ability with obvious pH and temperature double responsiveness, which is affected by the content of Oa-POSS slightly. All OP-PD gels exhibit an ultrarapid deswelling rate due to the interconnected micropores structure caused by freezing and the formation of microhydrophobic region around POSS particles. Moreover, the application potential of OP-PD gels in drug release was exploited by using flutamide as target drug, the result showed that the increased Oa-POSS could improve the drug loading ability, and OP-PD gels showed well controlled-release effect in simulated human stomachic condition. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2345-2355, 2016.
authors.affiliation: Department of Polymer Materials and Engineering, Institute of Packaging and Materials Engineering, Hunan University of Technology, Zhuzhou, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Polymer Materials and Engineering, Institute of Packaging and Materials Engineering, Hunan University of Technology, Zhuzhou, People's Republic of China.
authors.forename: Guangsheng
authors.initials: G
authors.lastname: Zeng
authors.affiliation: Department of Polymer Materials and Engineering, Institute of Packaging and Materials Engineering, Hunan University of Technology, Zhuzhou, People's Republic of China.
authors.forename: Wenyong
authors.initials: W
authors.lastname: Liu
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D005485:Flutamide / Q000737:chemistry* / Q000493:pharmacokinetics*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D020100:Hydrogels; D008689:Methacrylates; D009757:Nylons; D017646:Organosilicon Compounds; C407037:poly(2-(dimethylamino)ethyl methacrylate); C521417:polyhedraloligosilsesquioxane; D005485:Flutamide
keywords: POSS; double stimulus responsiveness; drug release; nanocomposite hydrogels