title: Inflammation as a Driver of Adverse Left Ventricular Remodeling After Acute Myocardial Infarction.
abstract: Treatment of acute myocardial infarction (AMI) has improved significantly in recent years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive change associated with progressive heart failure. Although this change is usually associated with large infarcts, some patients with relatively small infarcts have adverse remodeling, whereas other patients with larger infarcts (who survive the first several days after AMI) do not. This paper reviews the relevant data supporting the hypothesis that individual differences in the intensity of the post-AMI inflammatory response, involving 1 or more inflammatory-modulating pathways, may contribute to adverse LV remodeling. It concludes by outlining how individual variations in the inflammatory response could provide important novel therapeutic targets and strategies.
authors.affiliation: MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Westman
authors.affiliation: MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lipinski
authors.affiliation: MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC.
authors.forename: Dror
authors.initials: D
authors.lastname: Luger
authors.affiliation: MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC.
authors.forename: Ron
authors.initials: R
authors.lastname: Waksman
authors.affiliation: Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Robert O
authors.initials: RO
authors.lastname: Bonow
authors.affiliation: Northwestern Medical Group, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Edwin
authors.initials: E
authors.lastname: Wu
authors.affiliation: MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC. Electronic address: stephen.epstein@medstar.net.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Epstein
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications; D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000150:complications; D058847:Inflammasomes / Q000037:antagonists & inhibitors; D007249:Inflammation / Q000503:physiopathology* / Q000517:prevention & control; D045164:Mesenchymal Stem Cell Transplantation; D009203:Myocardial Infarction / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D018919:Neovascularization, Physiologic; D009504:Neutrophils / Q000378:metabolism; D011110:Polymorphism, Genetic; D013318:Stroke Volume / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058847:Inflammasomes
keywords: heart failure; infarct size; left ventricular function; stem cells