title: Disease-Induced Skeletal Muscle Atrophy and Fatigue.
abstract: Numerous health problems, including acute critical illness, cancer, diseases associated with chronic inflammation, and neurological disorders, often result in skeletal muscle weakness and fatigue. Disease-related muscle atrophy and fatigue is an important clinical problem because acquired skeletal muscle weakness can increase the duration of hospitalization, result in exercise limitation, and contribute to a poor quality of life. Importantly, skeletal muscle atrophy is also associated with increased morbidity and mortality of patients. Therefore, improving our understanding of the mechanism(s) responsible for skeletal muscle weakness and fatigue in patients is a required first step to develop clinical protocols to prevent these skeletal muscle problems. This review will highlight the consequences and potential mechanisms responsible for skeletal muscle atrophy and fatigue in patients experiencing acute critical illness, cancer, chronic inflammatory diseases, and neurological disorders.
authors.affiliation: 1Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL; 2Basic and Clinical Myology Laboratory, Department of Physiology, University of Melbourne, Victoria, AUSTRALIA; and 3Medical Physiology, Department of Neuroscience, University Medical Center Groningen, Groningen, THE NETHERLANDS.
authors.forename: Scott K
authors.initials: SK
authors.lastname: Powers
authors.forename: Gordon S
authors.initials: GS
authors.lastname: Lynch
authors.forename: Kate T
authors.initials: KT
authors.lastname: Murphy
authors.forename: Michael B
authors.initials: MB
authors.lastname: Reid
authors.forename: Inge
authors.initials: I
authors.lastname: Zijdewind
mesh_terms: D002100:Cachexia / Q000503:physiopathology; D002908:Chronic Disease; D016638:Critical Illness; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D018763:Muscle Fatigue / Q000502:physiology*; D009133:Muscular Atrophy / Q000503:physiopathology*; D009369:Neoplasms / Q000503:physiopathology; D009422:Nervous System Diseases / Q000503:physiopathology