title: Enhanced User-Control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tethers.
abstract: We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleratation of the release rate of an entrapped model drug.
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado, Boulder Colorado, 80303, United States.
authors.forename: E M
authors.initials: EM
authors.lastname: Nehls
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado, Boulder Colorado, 80303, United States; BioFrontiers Institute.
authors.forename: A M
authors.initials: AM
authors.lastname: Rosales
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado, Boulder Colorado, 80303, United States; BioFrontiers Institute; Howard Hughes Medical Institute.
authors.forename: K S
authors.initials: KS
authors.lastname: Anseth