title: Separation and concentration of natural products by fast forced adsorption using well-dispersed velvet-like graphitic carbon nitride with response surface methodology optimisation.
abstract: Well-dispersed velvet-like graphitic carbon nitride nanoparticles with a large surface area were prepared and utilized for separation and concentration of bioactive compounds from fruit extracts by fast (20s) forced adsorption. The large surface area, enhanced non-covalent interactions of this nanoparticle with bioactive compounds and good dispersity in different solvents benefited its application as a good sorbent. To evaluate their adsorption capabilities, these carbon nitride nanoparticles were used for separation and concentration of flavonoids from fruit extracts by a forced-adsorption dispersive solid phase extraction method. The combined use of this nanoparticle and our experimental conditions showed excellent precision (3.6-4.7%) and sensitivity (limits of detection (S/N=3): 0.6-3.75ng/mL). This research provides an alternative strategy to prepare suitable sorbents for adsorption, separation and concentration of various compounds from different extracts.
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Xinru
authors.initials: X
authors.lastname: Ding
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xia
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Department of Preventive Medicine and Health Management & College of Pharmacy, Hebei University, Baoding 071002, China. Electronic address: biwentao@njnu.edu.cn.
authors.forename: Wentao
authors.initials: W
authors.lastname: Bi
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. Electronic address: yangxiaodi@njnu.edu.cn.
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. Electronic address: yangjinfei@njnu.edu.cn.
authors.forename: Jinfei
authors.initials: J
authors.lastname: Yang
mesh_terms: D000327:Adsorption; D001688:Biological Products / Q000032:analysis*; D006108:Graphite; D009570:Nitriles; D052616:Solid Phase Extraction; D014874:Water Pollutants, Chemical
chemical_list: D001688:Biological Products; D009570:Nitriles; D014874:Water Pollutants, Chemical; C011206:cyanogen; D006108:Graphite
keywords: Carbon nitride; Flavonoid; Forced adsorption; Response surface methodology; Solid phase extraction