title: Cell-Assisted Lipotransfer Using Autologous Adipose-Derived Stromal Cells for Alleviation of Breast Cancer-Related Lymphedema.
abstract: : Lymphedema is one of the most frequent side effects following cancer treatment, and treatment opportunities for it are currently lacking. Stem cell therapy has been proposed as a possible novel treatment modality. This study was the first case in which freshly isolated adipose-derived stromal cells were used to treat lymphedema. Treatment was given as a cell-assisted lipotransfer in which 4.07 × 10(7) cells were injected with 10 ml of lipoaspirate in the axillary region. Four months after treatment, the patient reported a great improvement in daily symptoms, reduction in need for compression therapy, and volume reduction of her affected arm. There were no adverse events. The outcome for this patient provides support for the potential use of cellular therapy for lymphedema treatment. We have begun a larger study to further test the feasibility and safety of this procedure (ClinicalTrials.gov Identifier NCT02592213).
  
  
  CONCLUSIONS
  Lymphedema is a very debilitating side effect of cancer treatment and has very few treatment options. Stem cell therapy has the potential to change the treatment paradigm from a conservative to a more curative approach. Freshly isolated, autologous, adipose-derived stromal cells were combined with a fat-graft procedure to treat lymphedema. The treated patient had great improvement in daily symptoms, a reduced need for compression therapy, and a reduction in arm volume after 4 months. There were no adverse events. The use of cellular therapy for lymphedema treatment is supported by this patient's outcome. A phase II study has begun to further test its feasibility and safety.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Odense University Hospital, Odense, Denmark navid.m.toyserkani@rsyd.dk.
authors.forename: Navid Mohamadpour
authors.initials: NM
authors.lastname: Toyserkani
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
authors.forename: Charlotte Harken
authors.initials: CH
authors.lastname: Jensen
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
authors.forename: Søren Paludan
authors.initials: SP
authors.lastname: Sheikh
authors.affiliation: Department of Plastic and Reconstructive Surgery, Odense University Hospital, Odense, Denmark.
authors.forename: Jens Ahm
authors.initials: JA
authors.lastname: Sørensen
mesh_terms: D000273:Adipose Tissue / Q000166:cytology* / Q000637:transplantation; D001943:Breast Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000628:therapy*; D005260:Female; D006801:Humans; D015187:Lipectomy; D008197:Lymph Node Excision / Q000009:adverse effects; D008209:Lymphedema / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D011832:Radiation Injuries / Q000628:therapy; D017154:Stromal Cells / Q000166:cytology* / Q000637:transplantation*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
keywords: Adipose-derived regenerative cells; Adipose-derived stem cells; Adipose-derived stromal cells; Cell-based therapy; Lymphedema; Mesenchymal stem cell transplantation; Regenerative medicine; Stromal vascular fraction; Tissue-based therapy