title: New turn-on fluorescent and colorimetric probe for cyanide detection based on BODIPY-salicylaldehyde and its application in cell imaging.
abstract: Development of cyanide sensor is important as the anion is harmful to human health and the environment. Herein, a new colorimetric and fluorescent probe GSB based on boron dipyrrole-methene (BODIPY) containing salicylaldehyde group for cyanide detection has been reported. GSB undergoes exclusive colorimetric change from orange to colorless and exhibits selective fluorescence turn-on at 504nm upon the addition of cyanide. Other 13 anions give almost no interference under physiological condition. Detection limit of the new cyanide-sensing GSB is 0.88μM, which is below World Health Organization (WHO) recommended level in drinking water. A calculation by density functional theory (DFT) shows suppression of photoinduced electron transfer (PET) mechanism along with the interruption of π-conjugation between salicylaldehyde and BODIPY core by cyanide anion. Cell imaging studies demonstrated that GSB is compatible and capable of sensing cyanide anion in living cells.
authors.affiliation: Program of Petrochemistry and Polymer Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Rangsarit
authors.initials: R
authors.lastname: Sukato
authors.affiliation: Department of Microbiology, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand.
authors.forename: Nuanphan
authors.initials: N
authors.lastname: Sangpetch
authors.affiliation: Department of Microbiology, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand.
authors.forename: Tanapat
authors.initials: T
authors.lastname: Palaga
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Suthikorn
authors.initials: S
authors.lastname: Jantra
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Viwat
authors.initials: V
authors.lastname: Vchirawongkwin
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Chanantida
authors.initials: C
authors.lastname: Jongwohan
authors.affiliation: Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Mongkol
authors.initials: M
authors.lastname: Sukwattanasinitt
authors.affiliation: Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: sumrit.w@chula.ac.th.
authors.forename: Sumrit
authors.initials: S
authors.lastname: Wacharasindhu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D003124:Colorimetry / Q000295:instrumentation*; D003486:Cyanides / Q000737:chemistry*; D005456:Fluorescent Dyes; D056945:Hep G2 Cells; D006801:Humans
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000447:Aldehydes; D001896:Boron Compounds; D003486:Cyanides; D005456:Fluorescent Dyes; C013243:salicylaldehyde
keywords: BODIPY; Colorimetry; Cyanide; Fluorescence; Living cell