title: C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides.
abstract: This study describes our development of a novel and efficient procedure for C-O bond formation under mild conditions, for coupling heteroaryl chlorides with phenols or primary aliphatic alcohols. We utilized a continuous-flow microfluidic reactor for C-O bond formation in electron-deficient pyrimidines and pyridines in a much more facile manner with a cleaner reaction profile, high yield, quick scalability and without the need for the transition metal catalyst. This approach can be of general utility to make C-O bond containing intermediates of industrial importance in a continuous and safe manner.
authors.affiliation: Drug Discovery Laboratory, Department of Neurology, Mary S. Easton Center for Alzheimer's Disease Research, University of California, Los Angeles, CA 90095.
authors.forename: Mohammad Parvez
authors.initials: MP
authors.lastname: Alam
authors.affiliation: Drug Discovery Laboratory, Department of Neurology, Mary S. Easton Center for Alzheimer's Disease Research, University of California, Los Angeles, CA 90095.
authors.forename: Barbara
authors.initials: B
authors.lastname: Jagodzinska
authors.affiliation: Drug Discovery Laboratory, Department of Neurology, Mary S. Easton Center for Alzheimer's Disease Research, University of California, Los Angeles, CA 90095.
authors.forename: Jesus
authors.initials: J
authors.lastname: Campagna
authors.affiliation: Drug Discovery Laboratory, Department of Neurology, Mary S. Easton Center for Alzheimer's Disease Research, University of California, Los Angeles, CA 90095.
authors.forename: Patricia
authors.initials: P
authors.lastname: Spilman
authors.affiliation: Drug Discovery Laboratory, Department of Neurology, Mary S. Easton Center for Alzheimer's Disease Research, University of California, Los Angeles, CA 90095.
authors.forename: Varghese
authors.initials: V
authors.lastname: John
keywords: C–O bond; Flow chemistry; Micro-fluidic reactor; SNAr reaction