title: "One-Pot" Approach to 8-Acylated 2-Quinolinones via Palladium-Catalyzed Regioselective Acylation of Quinoline N-Oxides.
abstract: A "one-pot" facile and efficient protocol for 8-acylated 2-quinolinones has been developed through palladium-catalyzed acylation of quinoline N-oxides, which proceeds with high selectivity at the C8-position. The desired products were isolated in up to 95% yield and good functional group tolerance. A palladacycle was isolated from the catalytic process and proposed as a key intermediate.
authors.affiliation: Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University , Zhengzhou 450052, P. R. China.
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University , Zhengzhou 450052, P. R. China.|Xiamen Key Laboratory of Ocean and Gene Drugs, School of Biomedical Sciences, Institute of Molecular Medicine of Huaqiao University & Engineering Research Centre of Molecular Medicine of Chinese Education Ministry , Xiamen, Fujian 361021, P. R. China.
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University , Zhengzhou 450052, P. R. China.
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Wu