title: Thyroid hormones and cardiac remodeling.
abstract: Thyroid hormones have many cardioprotective actions expressed mainly through the action of T3 on thyroid receptors α1 and β1. They are procontractile anti-apoptotic, anti-inflammatory, and anti-fibrotic, promote angiogenesis and regeneration, and have beneficial effects on microRNA profiles. They have proven to be anti-remodeling in numerous animal studies, mostly in rodents; a specific action on the border zone has been described. Studies in humans with DIPTA have been in conclusion. Remodeling can be defined as an increase of ≥20 % of the end-diastolic or end-systolic volume, together with a return to the fetal phenotype. An overview of animal and clinical studies is given.
authors.affiliation: Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou St., 115 27, Athens, Greece. dcokkinos@bioacademy.gr.|Onassis Cardiac Surgery Center Athens, Athens, Greece. dcokkinos@bioacademy.gr.
authors.forename: Dennis V
authors.initials: DV
authors.lastname: Cokkinos
authors.affiliation: Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou St., 115 27, Athens, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Chryssanthopoulos
mesh_terms: D000818:Animals; D003971:Diastole / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods; D051379:Mice; D009203:Myocardial Infarction / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D013963:Thyroid Hormones / Q000502:physiology / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D013963:Thyroid Hormones
keywords: Cardiac remodeling; DIPTA; Myocardial infarction; Thyroid hormones; Thyroid receptors