title: Intraoral Pseudo-Onion Bulb Intraneural Proliferations in a Patient with Hemimandibular Hyperplasia: A Case Report and Review of the Literature.
abstract: This report and review of the literature describes a case of benign intraoral lesions of perineurial origin in a patient with symptomatic hemimandibular hyperplasia causing partial denture soreness. Perineuriomas are a benign peripheral nerve sheath tumor composed of perineurial cells. Intraoral perineuriomas are an extremely rare entity. Two main types of perineuriomas have been described: intraneural and extraneural perineuriomas. A third, similar entity, called an intraneural pseudoperineuriomatous proliferation, has recently been proposed in the literature as a separate and distinctive diagnosis. This report describes the histologic and clinical presentation of intraneural pseudoperineuriomatous proliferations in a patient with hemimandibular hyperplasia.
authors.affiliation: Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, G-132 Salk Hall, 3501 Terrace Street, Pittsburgh, PA, 15261, USA. vargorj@upmc.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Vargo
authors.affiliation: Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
authors.forename: Anitha
authors.initials: A
authors.lastname: Potluri
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Bauer
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 15261, USA.
authors.forename: Raja R
authors.initials: RR
authors.lastname: Seethala
authors.affiliation: Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Bilodeau
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D008336:Mandibular Diseases / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis / Q000473:pathology*; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis; D010525:Peripheral Nerves / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Fluorescence in situ hybridization; Hemimandibular hyperplasia; Immunohistochemistry; Intraneural pseudoperineuriomatous proliferation; Oral pathology; Perineurioma