title: Monitoring neovascularization in aggressive posterior retinopathy of prematurity using optical coherence tomography angiography.
abstract: We describe the use of optical coherence tomography angiography (OCTA) in detecting and monitoring regression of the neovascular complex (NVC) in a case of aggressive posterior retinopathy of prematurity (AP-ROP). A premature Asian Indian girl with AP-ROP underwent laser photoablation at 26 days of life. Persistent NVC at the posterior border of the lasered retinal bed was detected clinically. On en face spectral domain optical coherence tomography (SD-OCT) and OCTA, the NVC appeared as an arborizing vascular net in the superficial capillary plexus. The deep capillary plexus and outer retinal layers showed corresponding flow outlines that suggested deeper extensions of the lesion. Supplemental laser treatment of the NVC was performed. Ten days later repeat en face SD-OCT and OCTA of the identical retinal location revealed that the vascular tortuosity and dilatation had reduced and that the flow lesions in the deeper layers were undetectable. Our findings in this case suggest that the NVC in AP-ROP extends beyond the superficial retina.
authors.affiliation: Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India. Electronic address: anandvinekar@yahoo.com.
authors.forename: Anand
authors.initials: A
authors.lastname: Vinekar
authors.affiliation: Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Chidambara
authors.affiliation: Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India.
authors.forename: Chaitra
authors.initials: C
authors.lastname: Jayadev
authors.affiliation: Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India.
authors.forename: Munusamy
authors.initials: M
authors.lastname: Sivakumar
authors.affiliation: Department of Ophthalmology, Maastricht University, Netherlands.
authors.forename: Carroll A B
authors.initials: CA
authors.lastname: Webers
authors.affiliation: Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India.
authors.forename: Bhujang
authors.initials: B
authors.lastname: Shetty
mesh_terms: D005260:Female; D005451:Fluorescein Angiography; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D017075:Laser Coagulation; D053844:Lasers, Solid-State / Q000627:therapeutic use; D015861:Retinal Neovascularization / Q000175:diagnosis* / Q000601:surgery; D012171:Retinal Vessels / Q000473:pathology*; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000601:surgery; D041623:Tomography, Optical Coherence / Q000379:methods*