title: [The role of vascular endothelial growth factor in the regulation of development and functioning of the brain: new target molecules for pharmacotherapy].
abstract: Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair. Most of these actions involve VEGF-A and the VEGFR-2 receptor. VEGF signaling pathways represent an important potential for treatment of neurological diseases affecting the brain.
authors.affiliation: Voyno-Yasenetski Krasnoyarsk State Medical Academy, Krasnoyarsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Roslavtceva
authors.affiliation: Voyno-Yasenetski Krasnoyarsk State Medical Academy, Krasnoyarsk, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
authors.affiliation: Voyno-Yasenetski Krasnoyarsk State Medical Academy, Krasnoyarsk, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Prokopenko
authors.affiliation: Voyno-Yasenetski Krasnoyarsk State Medical Academy, Krasnoyarsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Pozhilenkova
authors.affiliation: Berzon Krasnoyarsk Regional Clinical Hospital N 20, Krasnoyarsk Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Kobanenko
authors.affiliation: Berzon Krasnoyarsk Regional Clinical Hospital N 20, Krasnoyarsk Russia.
authors.forename: G G
authors.initials: GG
authors.lastname: Rezvitskaya
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D015398:Signal Transduction; D020521:Stroke / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2
keywords: (VEGF); VEGF; brain; ischemic stroke; neurogenesis; neuroprotection; vascular endothelial growth factors