title: Preoperative Chemoradiotherapy for Rectal Cancer in Patients Aged 75 Years and Older: Acute Toxicity, Compliance with Treatment, and Early Results.
abstract: Treatment of locally advanced rectal cancer (T3-T4 or N+) is based on short-course radiotherapy (RT) or chemoradiotherapy (CRT) followed by surgery. It is estimated that 30-40 % of rectal cancer occurs in patients aged 75 years or more. Data on adherence to neoadjuvant CRT and its safety remain poor owing to the under-representation of older patients in randomized clinical trials and the discordance in the results from retrospective studies. The aim of this study was to assess adherence with preoperative CRT and tolerability in older patients with a stage II/III unresectable rectal cancer.
  
  
  
  Patients aged 75 years or more with stage II/III rectal cancer treated with preoperative CRT at the University Hospital of Besancon from 1993 to 2011 were included. Feasibility, toxicities, overall survival, and local recurrence rates were studied.
  
  
  
  Fifty-six patients with a Charlson score from 2 to 6 were included. The mean age was 78 years. The compliance rates for RT and chemotherapy were 91 and 41.1 %, respectively. Two patients stopped CRT; one for hemostatic surgery, and one for severe sepsis. For CRT, the rate of grade ≥3 toxicity was 14.29 %, mainly the digestive type. Fifty-two patients underwent tumor resection, including 76.79 % total mesorectal excision resection with 84.6 % complete resection, and a rate of postoperative complications of 39.6 %. At 2 years, the overall survival and local recurrences rates were 87.3 and 7.8 %, respectively.
  
  
  
  In older patients, selected preoperative CRT, with an adapted chemotherapy dose, is well tolerated. The main toxicity was gastrointestinal. Adherence to RT is comparable to that of younger patients.
authors.affiliation: Department of Radiation Oncology, Besançon University Hospital, University Hospital of Franche-Comté, Boulevard Fleming, 25030, Besançon Cedex, France.
authors.forename: Valentine
authors.initials: V
authors.lastname: Guimas
authors.affiliation: Department of Radiation Oncology, Besançon University Hospital, University Hospital of Franche-Comté, Boulevard Fleming, 25030, Besançon Cedex, France.
authors.forename: Jihane
authors.initials: J
authors.lastname: Boustani
authors.affiliation: Department of Radiation Oncology, Drevon Clinic, Dijon, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Schipman
authors.affiliation: Department of Radiation Oncology, Besançon University Hospital, University Hospital of Franche-Comté, Boulevard Fleming, 25030, Besançon Cedex, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lescut
authors.affiliation: Department of Clinical Investigation Center, Besançon University Hospital, Besançon, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Puyraveau
authors.affiliation: Department of Radiation Oncology, Besançon University Hospital, University Hospital of Franche-Comté, Boulevard Fleming, 25030, Besançon Cedex, France.
authors.forename: Jean François
authors.initials: JF
authors.lastname: Bosset
authors.affiliation: Department of Radiation Oncology, Besançon University Hospital, University Hospital of Franche-Comté, Boulevard Fleming, 25030, Besançon Cedex, France. stephanie.servagi@gmail.com.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Servagi-Vernat
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D059248:Chemoradiotherapy / Q000009:adverse effects* / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects* / Q000379:methods; D009364:Neoplasm Recurrence, Local; D010349:Patient Compliance / Q000706:statistics & numerical data; D011829:Radiation Dosage; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome