title: Synthesis of Oxazolidin-4-ones: Domino O-Alkylation/Aza-Michael/Intramolecular Retro-Claisen Condensation.
abstract: An original and rapid domino reaction for access to oxazolidin-4-ones is presented. Simply by heating α-bromoamido alcohol in the presence of KNaCO3 and water with readily prepared Michael acceptors, an unprecedented molecular rearrangement is generated. This new methodology enables the hitherto unreported synthesis of functionalized oxazolidin-4-ones. The process was proved to be compatible with a wide variety of substrates, and high regioselectivities were achieved.
authors.affiliation: Normandie Université , UNIHAVRE, URCOM, 76600 Le Havre 25, Rue Philipe Lebon, BP 540, F-76600 Le Havre, France.
authors.forename: Abderrahman
authors.initials: A
authors.lastname: El Bouakher
authors.affiliation: Normandie Université , UNIHAVRE, URCOM, 76600 Le Havre 25, Rue Philipe Lebon, BP 540, F-76600 Le Havre, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Le Goff
authors.affiliation: Normandie Université , UNIHAVRE, URCOM, 76600 Le Havre 25, Rue Philipe Lebon, BP 540, F-76600 Le Havre, France.
authors.forename: Jordan
authors.initials: J
authors.lastname: Tasserie
authors.affiliation: Université du Maine , IMMM, UMR 6283 CNRS, 72085 Le Mans, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lhoste
authors.affiliation: Université du Maine , IMMM, UMR 6283 CNRS, 72085 Le Mans, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Martel
authors.affiliation: Normandie Université , UNIHAVRE, URCOM, 76600 Le Havre 25, Rue Philipe Lebon, BP 540, F-76600 Le Havre, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Comesse