title: North American Thrombosis Forum, AF Action Initiative Consensus Document.
abstract: The North American Thrombosis Forum Atrial Fibrillation Action Initiative consensus document is a comprehensive yet practical briefing document focusing on stroke and bleeding risk assessment in patients with atrial fibrillation, as well as recommendations regarding anticoagulation options and management. Despite the breadth of clinical trial data and guideline recommendation updates, many clinicians continue to struggle to synthesize the disparate information available. This problem slows the uptake and utilization of updated risk prediction tools and adoption of new oral anticoagulants. This document serves as a practical and educational reference for the entire medical community involved in the care of patients with atrial fibrillation.
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: Cruff@partners.org.
authors.forename: Christian T
authors.initials: CT
authors.lastname: Ruff
authors.affiliation: Hofstra North Shore/LIJ School of Medicine, Hempstead, NY.
authors.forename: Jack E
authors.initials: JE
authors.lastname: Ansell
authors.affiliation: University of Cincinnati College of Medicine, University of Cincinnati Medical Center, Ohio.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Becker
authors.affiliation: Boston University School of Medicine and Public Health, Boston Medical Center, Boston, Mass.
authors.forename: Emelia J
authors.initials: EJ
authors.lastname: Benjamin
authors.affiliation: Brigham and Women's Hospital, Boston, Mass.
authors.forename: David J
authors.initials: DJ
authors.lastname: Deicicchi
authors.affiliation: Tufts Medical Center, Tufts University School of Medicine, Boston, Mass.
authors.forename: N A
authors.initials: NA
authors.lastname: Mark Estes
authors.affiliation: Lankenau Medical Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Ezekowitz
authors.affiliation: Massachusetts College of Pharmacy, Brigham and Women's Hospital, Northeastern University School of Pharmacy, Boston, Mass.
authors.forename: John
authors.initials: J
authors.lastname: Fanikos
authors.affiliation: Loyola University Medical Center, Loyola University Chicago Stritch School of Medicine, Ill.
authors.forename: Jawed
authors.initials: J
authors.lastname: Fareed
authors.affiliation: University of Washington Medical Center, University of Washington School of Medicine, Seattle, Wash.
authors.forename: David
authors.initials: D
authors.lastname: Garcia
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Giugliano
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Samuel Z
authors.initials: SZ
authors.lastname: Goldhaber
authors.affiliation: Duke University Medical Center, Duke University School of Medicine, Durham, NC.
authors.forename: Christopher
authors.initials: C
authors.lastname: Granger
authors.affiliation: Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Healey
authors.affiliation: Foothills Medical Center, University of Calgary, Alberta, Canada.
authors.forename: Russell
authors.initials: R
authors.lastname: Hull
authors.affiliation: Boston University School of Medicine and Public Health, Boston Medical Center, Boston, Mass.
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Hylek
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Peter
authors.initials: P
authors.lastname: Libby
authors.affiliation: Duke University Medical Center, Duke University School of Medicine, Durham, NC.
authors.forename: Renato D
authors.initials: RD
authors.lastname: Lopes
authors.affiliation: Stanford University Medical Center, Stanford University School of Medicine, Calif.
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Mahaffey
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Jessica
authors.initials: J
authors.lastname: Mega
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Gregory
authors.initials: G
authors.lastname: Piazza
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Sasahara
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Farzaneh A
authors.initials: FA
authors.lastname: Sorond
authors.affiliation: Hofstra North Shore/LIJ School of Medicine, Hempstead, NY.
authors.forename: Alex C
authors.initials: AC
authors.lastname: Spyropoulos
authors.affiliation: Loyola University Medical Center, Loyola University Chicago Stritch School of Medicine, Ill.
authors.forename: Jeanine M
authors.initials: JM
authors.lastname: Walenga
authors.affiliation: Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Weitz
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D000066491:Clinical Decision-Making / Q000379:methods; D020022:Genetic Predisposition to Disease; D006305:Health Status Indicators; D006470:Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D055118:Medication Adherence; D019990:Perioperative Care / Q000379:methods; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D015415:Biomarkers
keywords: Anticoagulants; Antithrombotic management; Atrial fibrillation; Bleeding risk; Stroke