title: Safety and Clinical Outcomes of Endovascular Treatment of Adult-Onset Pulmonary Artery Stenosis.
abstract: BACKGROUND
  Pulmonary artery stenosis (PAS) in adults is a rare condition. The role of endovascular stent implantation as a therapeutic option has not been clearly defined.
  
  
  RESULTS
  We performed a retrospective review of all cases of adult-onset PAS published in Pubmed/Medline from 1990 to 2013. A total of 126 cases of adult-onset PAS were identified, out of which 46 cases (37%) were treated with an endovascular intervention. Symptomatic improvement was reported in 98% of cases. Average translesional gradient at baseline was 47 ± 20 mm Hg, which reduced to 8 ± 11 mm Hg after stenting (P<.001). Mean preprocedural pulmonary systolic artery pressures were 79 ± 26 mm Hg, which reduced post procedure to 50 ± 20 mm Hg (P=.02). There were no immediate adverse events reported related to procedure. In-stent restenosis was reported in 7 cases on follow-up.
  
  
  CONCLUSIONS
  Endovascular treatment appears safe and effective for symptom relief in adult-onset PAS and should be considered as an alternative treatment option in patients with prohibitive surgical risk.
authors.forename: Mujeeb A
authors.initials: MA
authors.lastname: Sheikh
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Chowdhury
authors.affiliation: Division of Cardiovascular Medicine, The University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH 43614 USA. george.moukarbel@utoledo.edu.
authors.forename: George V
authors.initials: GV
authors.lastname: Moukarbel
mesh_terms: D000328:Adult; D000792:Angiography; D057510:Endovascular Procedures / Q000379:methods*; D006801:Humans; D000071079:Stenosis, Pulmonary Artery / Q000175:diagnosis / Q000601:surgery*