title: The Path to Thioredoxin and Redox Regulation in Chloroplasts.
abstract: After a brief discussion of my graduate work at Duke University, I describe a series of investigations on redox proteins at the University of California, Berkeley. Starting with ferredoxin from fermentative bacteria, the Berkeley research fostered experiments that uncovered a pathway for fixing CO2 in bacterial photosynthesis. The carbon work, in turn, opened new vistas, including the discovery that thioredoxin functions universally in regulating the Calvin-Benson cycle in oxygenic photosynthesis. These experiments, which took place over a 50-year period, led to the formulation of a set of biological principles and set the stage for research demonstrating a role for redox in the regulation of previously unrecognized processes extending far beyond photosynthesis.
authors.affiliation: Department of Plant and Microbial Biology, University of California, Berkeley, California 94720; email: view@berkeley.edu.
authors.forename: Bob B
authors.initials: BB
authors.lastname: Buchanan
mesh_terms: D002244:Carbon / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D041883:Chlorobium / Q000378:metabolism / Q000502:physiology*; D002736:Chloroplasts / Q000378:metabolism*; D002952:Citric Acid Cycle; D005287:Ferredoxin-NADP Reductase / Q000378:metabolism; D005288:Ferredoxins / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010788:Photosynthesis; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism; D013879:Thioredoxins / Q000378:metabolism*
chemical_list: D005288:Ferredoxins; D002245:Carbon Dioxide; D013879:Thioredoxins; D002244:Carbon; D005287:Ferredoxin-NADP Reductase; D013880:Thioredoxin-Disulfide Reductase; D010100:Oxygen
keywords: Autobiography; Chlorobium; Daniel Arnon; ferredoxin; pyruvate-ferredoxin oxidoreductase; reverse citric acid cycle