title: Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer's Disease.
abstract: Type 3 Diabetes (T3D) is a neuroendocrine disorder that represents the progression of Type 2 Diabetes Mellitus (T2DM) to Alzheimer's disease (AD). T3D contributes in the increase of the total load of Alzheimer's patients worldwide. The protein network based strategies were used for the analysis of protein interactions and hypothesis was derived describing the possible routes of communications among proteins. The hypothesis provides the insight on the probable mechanism of the disease progression for T3D. The current study also suggests that insulin degrading enzyme (IDE) could be the major player which holds the capacity to shift T2DM to T3D by altering metabolic pathways like regulation of beta-cell development, negative regulation of PI3K/AKT pathways and amyloid beta degradation.
authors.affiliation: Proteomic &Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201313, India.
authors.forename: Khyati
authors.initials: K
authors.lastname: Mittal
authors.affiliation: Proteomic &Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201313, India.
authors.forename: Ruchi Jakhmola
authors.initials: RJ
authors.lastname: Mani
authors.affiliation: Proteomic &Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201313, India.
authors.forename: Deepshikha Pande
authors.initials: DP
authors.lastname: Katare
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D030562:Databases, Protein; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D060066:Protein Interaction Maps; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins