title: Stable polyanhydride synthesized from sebacic acid and ricinoleic acid.
abstract: Poly(anhydride) are unstable and prone to hydrolytic degradation and depolymerisation via anhydride interchange. They are stored at -20°C, packed under inert atmosphere until use. We synthesized a new poly(anhydride) from ricinoleic (RA) and sebacic (SA) acid with alternating ester-anhydride structure that is stable at 25°C for over 18months. The copolymer is also stable in chloroform solution and under γ-irradiation. The polymer hydrolyses through anhydride cleavage lasting ~7days to form oligoesters, which are stable for >30days. The release of gentamycin from the synthesized alternate polymer matrix is sustained compared to the random copolymer.
authors.affiliation: School of Pharmacy, Institute of Drug Research, Hebrew University of Jerusalem, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Haim-Zada
authors.affiliation: School of Pharmacy, Institute of Drug Research, Hebrew University of Jerusalem, Israel.
authors.forename: Arijit
authors.initials: A
authors.lastname: Basu
authors.affiliation: Dexcel Pharma Technologies Ltd, Or-Akiva, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Hagigit
authors.affiliation: Dexcel Pharma Technologies Ltd, Or-Akiva, Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Schlinger
authors.affiliation: TAMI - Institute for Research & Development Ltd, Haifa Bay, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Grishko
authors.affiliation: TAMI - Institute for Research & Development Ltd, Haifa Bay, Israel.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kraminsky
authors.affiliation: TAMI - Institute for Research & Development Ltd, Haifa Bay, Israel.
authors.forename: Ezra
authors.initials: E
authors.lastname: Hanuka
authors.affiliation: School of Pharmacy, Institute of Drug Research, Hebrew University of Jerusalem, Israel. Electronic address: avid@ekmd.huji.ac.il.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D003652:Decanoic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D003998:Dicarboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D005839:Gentamicins / Q000008:administration & dosage; D006868:Hydrolysis; D049388:Polyanhydrides / Q000138:chemical synthesis* / Q000737:chemistry; D012277:Ricinoleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D003652:Decanoic Acids; D003692:Delayed-Action Preparations; D003998:Dicarboxylic Acids; D004952:Esters; D005839:Gentamicins; D049388:Polyanhydrides; D012277:Ricinoleic Acids; C011107:sebacic acid; C030521:ricinoleic acid
keywords: Alternating polymers; Anhydride interchange; Drug release; Poly anhydrides; Ricinoleic acid; Sebacic acid