title: Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population.
abstract: BACKGROUND
  IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection.
  
  
  OBJECTIVE
  The present study was designed to study the association between polymorphisms in interleukin-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and chronic hepatitis B virus (HBV) infection.
  
  
  METHODS
  221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method.
  
  
  RESULTS
  Persistent HBV infection was associated with IL-10-1082 AG (P = 0.001) and GG (P = 0.004) genotypes and G (P = 0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis B infection.
  
  
  CONCLUSIONS
  These results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection.
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran; Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Bita
authors.initials: B
authors.lastname: Moudi
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran; Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Heidari
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran; Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Mahmoudzadeh-Sagheb
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran; Department of Infectious Diseases, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Malihe
authors.initials: M
authors.lastname: Metanat
authors.affiliation: Blood Transfusion Research Center, High Institute for Research and Education in Medicine, Zahedan, IR Iran.
authors.forename: Soheila
authors.initials: S
authors.lastname: Khosravi
authors.affiliation: Department of Genetic, School of Biology, Damghan University, Damghan, IR Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Farrokh
keywords: Chronic Hepatitis B; Interleukin-10; Single Nucleotide Polymorphism