title: Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance.
abstract: Investigation of the aerial parts of two Spanish members of the Asteriscus alliance, Asteriscus graveolens subsp. stenophyllus and Asteriscus schultzii, afforded four new sesquiterpene lactones containing a humulene skeleton (1-4) and one new sesquiterpene lactone of the asteriscanolide type (5). Their chemical structures were determined on the basis of the HRMS and from 1D and 2D NMR spectroscopic studies. Both species showed different profiles of sesquiterpenoid constituents. A. schultzii did not show humulene or asteriscane sesquiterpenes, suggesting a resemblance to the genus Pallenis, another member of the Asteriscus alliance. A literature review on chemical isolates from the Asteriscus alliance supported the placement of A. schultzii in the genus Pallenis. The isolated components (1-5) were assessed for cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with compound 1 showing activity in both biological assays (IC50 value range 4.1-5.4 μM).
authors.affiliation: Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Triana
authors.affiliation: Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Eiroa
authors.affiliation: Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Morales
authors.affiliation: Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Perez
authors.affiliation: Instituto de Productos Naturales y Agrobiología-Consejo Superior de Investigaciones Científicas (CSIC) , Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Brouard
authors.affiliation: Departamento de Bioquímica, Universidad de Las Palmas de Gran Canaria , Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Quintana
authors.affiliation: Departamento de Bioquímica, Universidad de Las Palmas de Gran Canaria , Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Ruiz-Estévez
authors.affiliation: Departamento de Bioquímica, Universidad de Las Palmas de Gran Canaria , Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Estévez
authors.affiliation: Instituto de Productos Naturales y Agrobiología-Consejo Superior de Investigaciones Científicas (CSIC) , Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: León
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D000081222:Monocyclic Sesquiterpenes; D035261:Plant Components, Aerial / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013030:Spain
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C449084:asteriscanolide; C042686:humulene