title: Acute Fibrinous and Organizing Pneumonia Associated With Allogenic Hematopoietic Stem Cell Transplant Successfully Treated With Corticosteroids: A Two-Patient Case Series.
abstract: Acute fibrinous and organizing pneumonia (AFOP) is an extremely rare, relatively new, and distinct histological pattern of acute lung injury characterized predominately by the presence of intra-alveolar fibrin and associated organizing pneumonia. AFOP may be idiopathic or associated with a wide spectrum of clinical conditions. It has a variable clinical presentation from mild respiratory symptoms to that similar to the acute respiratory distress syndrome. Currently there is no consensus on treatment, and corticosteroids previously were of unclear benefit. To date, there are less than 40 cases of AFOP reported in the literature and only one has been linked to hematopoietic stem cell transplantation. Here we report the first case series of 2 patients who developed AFOP following allogenic stem cell transplant that were successfully treated with high-dose corticosteroids.
authors.affiliation: University of California, Davis, CA, USA; VA Northern California Health Care System, Mather, CA, USA.
authors.forename: Lam-Phuong
authors.initials: LP
authors.lastname: Nguyen
authors.affiliation: University of California, Davis, CA, USA; VA Northern California Health Care System, Mather, CA, USA.
authors.forename: Stella
authors.initials: S
authors.lastname: Ahdoot
authors.affiliation: University of California, Davis, CA, USA; VA Northern California Health Care System, Mather, CA, USA.
authors.forename: Narin
authors.initials: N
authors.lastname: Sriratanaviriyakul
authors.affiliation: University of California, Davis, CA, USA.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: University of California, Davis, CA, USA; VA Northern California Health Care System, Mather, CA, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Stollenwerk
authors.affiliation: University of California, Davis, CA, USA; VA Northern California Health Care System, Mather, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Schivo
authors.affiliation: University of California, Davis, CA, USA; VA Northern California Health Care System, Mather, CA, USA.
authors.forename: Richart
authors.initials: R
authors.lastname: Harper
keywords: AFOP; ARDS; BOOP; allogenic stem cell transplant; diffuse alveolar damage