title: Langerhan's Cell Sarcoma: Two Case Reports.
abstract: Langerhan's cell sarcoma (LCS) is a rare neoplasm with a poor prognosis. To our knowledge, only sixty-six cases have been published. We discuss two patients who presented very differently with LCS, as well as a recently published review of all sixty-six cases. Our first case had a complicated history of metastatic, high-grade myxofibrosarcomas and presented with a single skin lesion of LCS which was treated with resection to a positive margin and adjuvant radiotherapy. The LCS recurred locoregionally and was again resected. The patient is alive two years after initial diagnosis. The second case presented with bone marrow and splenic involvement, leukocytosis, and thrombocytopenia. This patient had an excellent response to etoposide, prednisone, oncovorin, cyclophosphamide, and adriamycin, with normalization of the complete blood count, negative bone marrow biopsy at follow up, and splenectomy without viable neoplasm. This patient is alive without signs of disease at 16 months after initial diagnosis.
authors.affiliation: Department of Radiation Oncology, Mayo Clinic Florida , Jacksonville, FL, USA.
authors.forename: Tasneem A
authors.initials: TA
authors.lastname: Kaleem
authors.affiliation: Department of Radiation Oncology, Mayo Clinic Florida , Jacksonville, FL, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Schild
authors.affiliation: Department of Radiation Oncology, Mayo Clinic Florida , Jacksonville, FL, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Miller
authors.affiliation: Department of Oncology, Mayo Clinic Health System in Waycross , Waycross, GA, USA.
authors.forename: Asit
authors.initials: A
authors.lastname: Jha
authors.affiliation: Department of Pathology, Mayo Clinic Florida , Jacksonville, FL, USA.
authors.forename: Cherise
authors.initials: C
authors.lastname: Cortese
authors.affiliation: Department of Oncology, Mayo Clinic Florida , Jacksonville, FL, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Attia
authors.affiliation: Department of Radiation Oncology, Mayo Clinic Florida , Jacksonville, FL, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Miller
keywords: Langerhan’s; Medicine; cancer; oncology; rare; sarcoma; tumor