title: Regulatory roles of mast cells in immune responses.
abstract: Mast cells are important immune cells for host defense through activation of innate immunity (via toll-like receptors or complement receptors) and acquired immunity (via FcεRI). Conversely, mast cells also act as effector cells that exacerbate development of allergic or autoimmune disorders. Yet, several lines of evidence show that mast cells act as regulatory cells to suppress certain inflammatory diseases. Here, we review the mechanisms by which mast cells suppress diseases.
authors.affiliation: Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, 157-8535, Japan.|Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, 7270, Switzerland.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Morita
authors.affiliation: Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, 157-8535, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Saito
authors.affiliation: Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, 157-8535, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan. snakae@ims.u-tokyo.ac.jp.|Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama, 332-0012, Japan. snakae@ims.u-tokyo.ac.jp.
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakae
mesh_terms: D056704:Adaptive Immunity; D064591:Allografts / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000378:metabolism; D003877:Dermatitis, Contact / Q000209:etiology / Q000378:metabolism; D006084:Graft Rejection / Q000276:immunology / Q000378:metabolism; D006086:Graft vs Host Disease / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007109:Immunity; D007113:Immunity, Innate; D007073:Immunoglobulin E / Q000276:immunology / Q000378:metabolism; D056747:Immunomodulation; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism*; D016038:Skin Transplantation / Q000009:adverse effects / Q000379:methods
chemical_list: D007073:Immunoglobulin E
keywords: Contact hypersensitivity; Graft-versus-host disease; Innate-type allergic airway inflammation; Mast cell; Rejection