title: Use of Phthalimidoacetyl Isothiocyanate as a Scaffold in the Synthesis of Target Heterocyclic Systems, and Their Antimicrobial Assessment.
abstract: Phthalimidoacetyl isothiocyanate underwent addition-cyclization reactions with some nitrogen and carbon nucleophilic reagents. Simultaneous or subsequent cyclization of the obtained adducts gave target heterocyclic systems such as 1,2,4-triazoles, 1,3-diazines, 1,3-oxazines and thiourea attached to a phthalimido moiety. The antimicrobial activity of the synthesized compounds was tested.
authors.affiliation: Department of Chemistry, Faculty of Science, Ain Shams University.
authors.forename: Magdy Mohamed
authors.initials: MM
authors.lastname: Hemdan
authors.forename: Amira Abd-Elhaleem
authors.initials: AA
authors.lastname: El-Sayed
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003500:Cyclization; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017879:Isothiocyanates / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010797:Phthalimides / Q000737:chemistry*; D012485:Salmonella typhi / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D017879:Isothiocyanates; D010797:Phthalimides