title: Effect of passive immunotherapy against Clostridium difficile infection: a systematic review and meta-analysis.
abstract: This systematic review aimed to determine the effect of antibody therapy against Clostridium difficile infection (CDI) using meta-analysis. In total, 28 studies (animals - 12; human - 17) were identified from the database on the basis of inclusion criteria; then selected studies were systematically reviewed and statistically analyzed. In animal experiments, the pooled relative risk of eight potential studies suggested that the antibody treatment could reduce the risk of CDI. However, the methodological heterogeneity was moderately higher. In human subjects, the majority of reports demonstrated the beneficial effect of passive immunotherapy against CDI. However, this systematic review and meta-analysis recommends that more intensive controlled studies are indispensable for legitimate confirmation.
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, China.
authors.forename: Thirumalai
authors.initials: T
authors.lastname: Diraviyam
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, China.
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: He
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, China.|College of Science, Northwest A&F University, Yangling, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.affiliation: PSG College of Arts & Science, Bharathiar University, Coimbatore, Tamil Nadu, India.
authors.forename: Antonysamy
authors.initials: A
authors.lastname: Michael
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016360:Clostridioides difficile / Q000276:immunology*; D004761:Enterocolitis, Pseudomembranous / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D012306:Risk
chemical_list: D000907:Antibodies, Bacterial
keywords: CDI; Clostridium difficile; antibiotics; diarrhea; immunoglobulin; immunotherapy; meta-analysis; nosocomial infection; systematic review