title: An Overview of B-1 Cells as Antigen-Presenting Cells.
abstract: The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response.
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Ana F
authors.initials: AF
authors.lastname: Popi
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Ieda M
authors.initials: IM
authors.lastname: Longo-Maugéri
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Mario
authors.initials: M
authors.lastname: Mariano
keywords: APCs; B-1 cells; BCR; TLR; autoimmune diseases