title: Regulation of the neural niche by the soluble molecule Akhirin.
abstract: Though the adult central nervous system has been considered a comparatively static tissue with little turnover, it is well established today that new neural cells are generated throughout life. Neural stem/progenitor cells (NS/PCs) can self-renew and generate all types of neural cells. The proliferation of NS/PCs, and differentiation and fate determination of PCs are regulated by extrinsic factors such as growth factors, neurotrophins, and morphogens. Although several extrinsic factors that influence neurogenesis have already been reported, little is known about the role of soluble molecules in neural niche regulation. In this review, we will introduce the soluble molecule Akhirin and discuss its role in the eye and spinal cord during development.
authors.affiliation: Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.|Program for Leading Graduate Schools HIGO (Health Life Science: Interdisciplinary and Glocal Oriented), Kumamoto University, Kumamoto, 860-8556, Japan.
authors.forename: Uzzal Kumar
authors.initials: UK
authors.lastname: Acharjee
authors.affiliation: Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.|Stem Cell-Based Tissue Regeneration Research and Education Unit, Kumamoto University, Kumamoto, 860-8556, Japan.|Department of Biology, Faculty of Applied Science, Umm Al-Qura University, 21955, Makkah, Saudi Arabia.
authors.forename: Athary Abdulhaleem
authors.initials: AA
authors.lastname: Felemban
authors.affiliation: Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.|Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, 95817, USA.
authors.forename: Asrafuzzaman M
authors.initials: AM
authors.lastname: Riyadh
authors.affiliation: Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.|Stem Cell-Based Tissue Regeneration Research and Education Unit, Kumamoto University, Kumamoto, 860-8556, Japan.|Japan Agency for Medical Research and Development (AMED), Tokyo, 100-0004, Japan.
authors.forename: Kunimasa
authors.initials: K
authors.lastname: Ohta
mesh_terms: D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*; D055153:Stem Cell Niche / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins
keywords: Akhirin; eye; neural stem cells; niche; spinal cord