title: The Modified Hand Mobility in Scleroderma Test and Skin Involvement - A Followup Study.
abstract: To study the change in the modified Hand Mobility in Scleroderma (mHAMIS) test from early to advanced stages of systemic sclerosis (SSc), and the relationship between mHAMIS and skin involvement during followup.
  
  
  
  This retrospective study includes 65 patients with baseline disease duration of ≤ 3 years who were assessed with the mHAMIS test at baseline and at 1 or 2 predefined followup points (3.1-5 yrs and 5.1-9 yrs after disease onset). Studied measures were the modified Rodnan skin score (mRSS), mRSS of the hand, serum cartilage oligomeric matrix protein, and digital vascular lesions.
  
  
  
  The mHAMIS and the mRSS hand changed synchronously during the first 5 years after disease onset (rs = 0.44, p = 0.001). In the group with high mHAMIS at baseline, both mHAMIS and mRSS hand improved significantly at the first followup (p < 0.05), and the improvement sustained during the followup in the mRSS hand. Patients with antitopoisomerase I and anti-RNA polymerase III antibodies had significantly higher mHAMIS at baseline (p = 0.003) and at the second followup (p = 0.030) compared to patients with anticentromere antibodies. Patients with digital vascular lesions at baseline had significantly higher mHAMIS during the followup (p < 0.05) compared to patients without. The mHAMIS improved significantly during the followup in patients with immunosuppressive treatment in early disease (p < 0.05), but not in patients without this treatment.
  
  
  
  The mHAMIS reflects disease activity in fibrosis in early stages of SSc. In later stages it can be regarded as a measure of damage arising from fibrotic and vascular involvement, making it suitable as an endpoint in followup examinations.
authors.affiliation: From the Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Skåne University Hospital, Lund, Sweden.G. Sandqvist, RegOT, PhD; D.M. Wuttge, MD, PhD; R. Hesselstrand, MD, PhD, Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Skåne University Hospital. gunnel.sandqvist@med.lu.se.
authors.forename: Gunnel
authors.initials: G
authors.lastname: Sandqvist
authors.affiliation: From the Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Skåne University Hospital, Lund, Sweden.G. Sandqvist, RegOT, PhD; D.M. Wuttge, MD, PhD; R. Hesselstrand, MD, PhD, Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Skåne University Hospital.
authors.forename: Dirk M
authors.initials: DM
authors.lastname: Wuttge
authors.affiliation: From the Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Skåne University Hospital, Lund, Sweden.G. Sandqvist, RegOT, PhD; D.M. Wuttge, MD, PhD; R. Hesselstrand, MD, PhD, Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Skåne University Hospital.
authors.forename: Roger
authors.initials: R
authors.lastname: Hesselstrand
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D064236:Cartilage Oligomeric Matrix Protein / Q000097:blood; D005260:Female; D005355:Fibrosis / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D005500:Follow-Up Studies; D006225:Hand / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology*
chemical_list: D001323:Autoantibodies; D064236:Cartilage Oligomeric Matrix Protein
keywords: MODIFIED HAND MOBILITY IN SCLERODERMA TEST; SYSTEMIC SCLEROSIS