title: A novel oxidative stress marker in migraine patients: dynamic thiol-disulphide homeostasis.
abstract: The aim of this study was to investigate dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in migraine patients. A total of 115 participants were included in the study, and 63 of whom were diagnosed with migraine. The total thiol (-SH+-S-S-) and native thiol (-SH) levels in the serum were measured in all patients and healthy individuals. The dynamic disulphide bond (-S-S-) and (-S-S-) × 100/(-SH), (-S-S-) × 100/(-SH+-S-S-), and -SH × 100/(-SH+-S-S-) ratios were calculated from these values. The total and native thiol levels of migraine patients participating in the study were found to be significantly higher than the total and native thiol levels of healthy individuals. No statistically significant difference was determined in terms of the dynamic disulphide bond amounts or (-S-S-) × 100/(-SH), (-S-S-) × 100/(-SH+-S-S-), and -SH × 100/(-SH+-S-S-) ratios. The total thiol, native thiol, and dynamic disulphide bond levels, and (-S-S-) × 100/(-SH), (-S-S-) × 100/(-SH+-S-S-), and -SH × 100/(-SH+-S-S-) ratios were not correlated with attack frequency, pain intensity, or migraine type. Oxidative stress is considered to be one of the molecular changes underlying the pathogenesis of migraine.
authors.affiliation: Department of Neurology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey. sadiyetemel@yahoo.com.
authors.forename: Sadiye
authors.initials: S
authors.lastname: Gumusyayla
authors.affiliation: Department of Neurology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
authors.forename: Gonul
authors.initials: G
authors.lastname: Vural
authors.affiliation: Department of Neurology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Hesna
authors.initials: H
authors.lastname: Bektas
authors.affiliation: Department of Biochemistry, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neselioglu
authors.affiliation: Department of Neurology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Deniz
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002648:Child; D004220:Disulfides / Q000097:blood*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D013438:Sulfhydryl Compounds; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Dynamic thiol–disulphide homeostasis; Migraine; Oxidative stress; Thiol metabolism