title: Synthesis and antiproliferative activity of D-ring substituted steroidal benzamidothiazoles.
abstract: Using progesterone as the starting material, we synthesized a series of steroidal derivatives possessing a D-ring substituted benzamidothiazole. All of the final structures were reported and identified by NMR and HRMS spectrometry for the first time. The antiproliferative activity of the synthesized compounds against PC-3 (human prostate cancer cell line) and SKOV-3 (ovarian cancer cells) were investigated. The preliminary results showed that compounds 8b, 8d and 8g possessed moderate antiproliferative activities.
authors.affiliation: Biochemistry and Molecular Biology Research Platform, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address: fannj1980@nwsuaf.edu.cn.
authors.forename: Ning-Juan
authors.initials: NJ
authors.lastname: Fan
authors.affiliation: Shaanxi Engineering Center of Bio-resource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Qiu-Rui
authors.initials: QR
authors.lastname: He
authors.affiliation: Biochemistry and Molecular Biology Research Platform, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Min
authors.initials: M
authors.lastname: Duan
authors.affiliation: Shaanxi Engineering Center of Bio-resource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Bai
authors.affiliation: Shaanxi Engineering Center of Bio-resource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address: tangjiang11@nwsuaf.edu.cn.
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids
keywords: Antiproliferative activity; Progesterone; Steroidal derivatives; Thiazole