title: Cross Talk Pathways Between Coagulation and Inflammation.
abstract: Anatomic pathology studies performed over 150 years ago revealed that excessive activation of coagulation occurs in the setting of inflammation. However, it has taken over a century since these seminal observations were made to delineate the molecular mechanisms by which these systems interact and the extent to which they participate in the pathogenesis of multiple diseases. There is, in fact, extensive cross talk between coagulation and inflammation, whereby activation of one system may amplify activation of the other, a situation that, if unopposed, may result in tissue damage or even multiorgan failure. Characterizing the common triggers and pathways are key for the strategic design of effective therapeutic interventions. In this review, we highlight some of the key molecular interactions, some of which are already showing promise as therapeutic targets for inflammatory and thrombotic disorders.
authors.affiliation: From the Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom (J.H.F.); Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free NHS Trust, London, United Kingdom (J.H.F.); and Centre for Blood Research, Department of Medicine, University of British Columbia, Vancouver, Canada (E.M.C.).
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Foley
authors.affiliation: From the Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom (J.H.F.); Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free NHS Trust, London, United Kingdom (J.H.F.); and Centre for Blood Research, Department of Medicine, University of British Columbia, Vancouver, Canada (E.M.C.). ed.conway@ubc.ca.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Conway
mesh_terms: D000818:Animals; D065206:Extracellular Traps / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D007113:Immunity, Innate; D011486:Protein C / Q000378:metabolism; D012697:Serine Endopeptidases / Q000097:blood; D015398:Signal Transduction; D013927:Thrombosis / Q000097:blood*
chemical_list: D011486:Protein C; D012697:Serine Endopeptidases
keywords: complement; contact activation; endothelial; monocyte; platelet thrombosis