title: Vibrio vulnificus infection and liver cirrhosis: a potentially lethal combination.
abstract: We present a case of a 40-year-old man with decompensated alcoholic liver cirrhosis presenting with atraumatic cellulitis of one extremity and severe sepsis that rapidly progressed to compartment syndrome despite broad-spectrum antibiotics. Local cultures following debridement revealed Vibrio vulnificus, and subsequent history revealed consumption of raw oysters 48 h before presentation. Our case points out the unique susceptibility of those with cirrhosis and elevated iron saturation to Vibrio septicaemia, as well as the rapidity and severity of the disease progression.
authors.affiliation: Reading Hospital & Medical Center, Reading, Pennsylvania, USA.
authors.forename: Salik
authors.initials: S
authors.lastname: Nazir
authors.affiliation: Reading Hospital & Medical Center, Reading, Pennsylvania, USA.
authors.forename: Krysta
authors.initials: K
authors.lastname: Brown
authors.affiliation: Department of Infectious Disease, Reading Hospital and Medical Center, Reading, Pennsylvania, USA.
authors.forename: Ann Kyungwohn
authors.initials: AK
authors.lastname: Shin
authors.affiliation: Reading Hospital & Medical Center, Reading, Pennsylvania, USA.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Donato
mesh_terms: D000328:Adult; D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use; D003646:Debridement; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D042241:Early Diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D010125:Ostreidae / Q000382:microbiology; D066256:Raw Foods / Q000382:microbiology*; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D014735:Vibrio Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery
chemical_list: D002939:Ciprofloxacin; D004318:Doxycycline