title: Synchronous gastrointestinal cancer and gastrointestinal stromal tumors: a single-institution experience.
abstract: BACKGROUND
  A study was conducted to investigate the clinicopathological features and survival outcomes of gastrointestinal stromal tumors (GISTs) that are synchronous with other gastrointestinal cancers.
  
  
  METHODS
  Clinical and pathological data of 286 patients with primary GIST from a single institution from January 2009 to December 2014 were reviewed.
  
  
  RESULTS
  The entire study population comprised 286 patients with GISTs. Of these patients, 167 (58.4%) were males and 119 (41.6%) were females. The median age was 58 years old (in the range 29-86 years). A total of 47 patients were diagnosed with GISTs synchronous with other digestive tract malignancies (synchronous group), whereas 239 patients were diagnosed with non-synchronous disease (non-synchronous group). The concomitant digestive tumors in 27, 12, 7, and 1 patients were diagnosed as gastric carcinoma, esophageal carcinoma, colorectal carcinoma, and pancreatic adenocarcinoma, respectively. Compared with the synchronous group, the non-synchronous group exhibited a higher percentage of increased mitotic count (P = 0.011). The difference in tumor diameter between the two groups was statistically significant (P < 0.001). Patients in the non-synchronous group exhibited larger tumor size than the patients in the synchronous group (5.9 ± 3.5 cm vs. 1.6 ± 0.4 cm, P < 0.001). The majority of GIST lesions in the synchronous group were located in the stomach (P = 0.020). Lower risk stratifications and worse ECOG performance statuses were observed in the synchronous group (P < 0.001) than in the non-synchronous group. The 5-year overall survival rate was significantly higher in patients with no synchronous digestive tract malignancies than in patients with synchronous disease (70.8 vs. 34.1%, P < 0.001).
  
  
  CONCLUSIONS
  Patients with GIST synchronous with other gastrointestinal cancers show worse prognosis than those with non-synchronous tumors. Clinicians should pay more attention to this subgroup.
authors.affiliation: Department of General Surgery, Suining Municipal Hospital of Traditional Chinese Medicine, Suining, 629000, Sichuan, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of General Surgery, Suining Municipal Hospital of Traditional Chinese Medicine, Suining, 629000, Sichuan, China. shenning1995@126.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Shen
authors.affiliation: Department of General Surgery, Suining Municipal Hospital of Traditional Chinese Medicine, Suining, 629000, Sichuan, China.
authors.forename: Hai-Shan
authors.initials: HS
authors.lastname: He
authors.affiliation: Department of General Surgery, Suining Municipal Hospital of Traditional Chinese Medicine, Suining, 629000, Sichuan, China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Fu
authors.affiliation: Department of General Surgery, Suining Municipal Hospital of Traditional Chinese Medicine, Suining, 629000, Sichuan, China.
authors.forename: Jing-Zhong
authors.initials: JZ
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Suining Municipal Hospital of Traditional Chinese Medicine, Suining, 629000, Sichuan, China.
authors.forename: Chong-Zhou
authors.initials: CZ
authors.lastname: Mao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000473:pathology* / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate
keywords: Clinicopathological; Digestive malignant tumors; Gastrointestinal stromal tumors; Prognosis; Synchronous