title: Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release.
abstract: During the last decade, using versatile, promising, and fascinating mesoporous silica nanoparticles (MSNs) as site-specific and stimuli-responsive drug delivery systems (DDSs) has received concentrated research interest. As one of the most attractive surface modification units, peptides have inherent bioactivity, biodegradability and biocompatibility. Recent progresses in the utilization of versatile peptides for surface functionalization of MSNs to achieve cell-specific targeting, fluorescence imaging, and intracellular diagnosis and treatment of tumors are summarized in this review. The various functional peptides decorated on the MSNs are introduced and classified into three types, including targeting peptides, stimuli-responsive peptides and multifunctional chimeric peptides. The limitations and challenges of peptide modified MSNs and their potential applications are further discussed.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies (IAS), Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Hu
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies (IAS), Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies (IAS), Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D010455:Peptides; D012822:Silicon Dioxide
keywords: drug delivery systems; peptides; silica nanoparticles; stimuli responsive; targets