title: Long-term survival with repeated resections of recurrent hepatocellular carcinoma in a non-cirrhotic liver: case report and brief review of the literature.
abstract: A healthy and asymptomatic 55-year-old woman underwent a complete (R0) non-anatomical resection of an incidentally detected solitary hepatocellular carcinoma (HCC) in a non-cirrhotic liver. Six years following the initial R0 non-anatomical resection, intrahepatic recurrence was diagnosed and the patient underwent a second R0 non-anatomical resection. At 12.5 years following the initial resection, a further intrahepatic recurrence was diagnosed, which was once again completely resected by left lateral hepatectomy. This represents one of the longest reported periods between initial resection and HCC recurrence, following repeated R0 resections in the absence of cirrhosis. The appropriate surveillance period and genetic testing protocol for such cases remains to be established.
authors.affiliation: 1 Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, UK ; 2 Department of HPB & Liver Transplant Surgery, Royal Free Hospital, London, UK ; 3 Department of Pharmacy & Forensic Science, King's College London, Strand, London, UK ; 4 Research Department of General Surgery, University College London, Gower Street, London, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hadjittofi
authors.affiliation: 1 Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, UK ; 2 Department of HPB & Liver Transplant Surgery, Royal Free Hospital, London, UK ; 3 Department of Pharmacy & Forensic Science, King's College London, Strand, London, UK ; 4 Research Department of General Surgery, University College London, Gower Street, London, UK.
authors.forename: Panagiotis G
authors.initials: PG
authors.lastname: Athanasopoulos
authors.affiliation: 1 Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, UK ; 2 Department of HPB & Liver Transplant Surgery, Royal Free Hospital, London, UK ; 3 Department of Pharmacy & Forensic Science, King's College London, Strand, London, UK ; 4 Research Department of General Surgery, University College London, Gower Street, London, UK.
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Koti
authors.affiliation: 1 Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, UK ; 2 Department of HPB & Liver Transplant Surgery, Royal Free Hospital, London, UK ; 3 Department of Pharmacy & Forensic Science, King's College London, Strand, London, UK ; 4 Research Department of General Surgery, University College London, Gower Street, London, UK.
authors.forename: Sofia K
authors.initials: SK
authors.lastname: Konstantinidou
authors.affiliation: 1 Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, UK ; 2 Department of HPB & Liver Transplant Surgery, Royal Free Hospital, London, UK ; 3 Department of Pharmacy & Forensic Science, King's College London, Strand, London, UK ; 4 Research Department of General Surgery, University College London, Gower Street, London, UK.
authors.forename: Brian R
authors.initials: BR
authors.lastname: Davidson
keywords: Hepatocellular; cirrhosis; hepatectomy; liver; recurrent