title: DELINEATION OF CHOROIDAL AND RETINAL LESIONS IN POSTERIOR UVEITIS BY MULTISPECTRAL WIDE-FIELD SCANNING LASER OPHTHALMOSCOPY.
abstract: OBJECTIVE
  To investigate whether wide-field multispectral scanning laser ophthalmoscopy could assist in determining depth of chorioretinal pathology in posterior uveitis.
  
  
  METHODS
  Cross-sectional retrospective review of patients with birdshot chorioretinopathy (BCR; 42 eyes of 21 patients) or active primary vitreoretinal lymphoma (PVRL; 18 eyes of 10 patients) who had multispectral wide-field scanning laser ophthalmoscopy (Optos) images. Images acquired with 532 nm and 635 nm lasers were analyzed separately using Optos V Vantage Pro Review software.
  
  
  RESULTS
  All 42 eyes with birdshot chorioretinopathy and 8/18 eyes with active primary vitreoretinal lymphoma had lesions on 635 nm imaging, while 26/42 of the birdshot chorioretinopathy eyes and 18/18 eyes with active primary vitreoretinal lymphoma had lesions on 532 nm imaging. The difference between the 2 groups on both 635 nm and 532 nm was statistically significant (P < 0.05).
  
  
  CONCLUSIONS
  Retinal and choroidal lesions in patients with posterior uveitis can be differentially visualized with Optos 532 nm and 635 nm lasers, respectively, allowing determination of depth of pathology.
authors.affiliation: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Jared E
authors.initials: JE
authors.lastname: Knickelbein
authors.forename: Jesia
authors.initials: J
authors.lastname: Hasan
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: H Nida
authors.initials: HN
authors.lastname: Sen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000080365:Birdshot Chorioretinopathy; D002825:Chorioretinitis / Q000175:diagnosis*; D015862:Choroid Diseases / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D064090:Intraocular Lymphoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D012164:Retinal Diseases / Q000175:diagnosis*; D012189:Retrospective Studies; D015866:Uveitis, Posterior / Q000175:diagnosis*