title: Misclassification of Antiretroviral Treatment Failure Using WHO 2006 and 2010/2013 Immunologic Criteria in HIV-Infected Children and Adolescents in Western Kenya.
abstract: We evaluated treatment failure misclassification in human immunodeficiency virus-infected Kenyan children whose targeted viral loads were determined after suspected immunologic/clinical failure according to 2006 and 2010/2013 World Health Organization guidelines. The misclassification rate was 21% for the 2006 guidelines and 46% for the 2010/2013 guidelines, which supports current recommendations for routine viral load monitoring but not necessarily the proposed CD4 thresholds.
authors.affiliation: Global Institute for Health and Human Rights, State University of New York at Albany.|Department of Pediatrics, Albany Medical College, New York.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Dufort
authors.affiliation: Center for Statistical Sciences, School of Public Health, Brown University.
authors.forename: Allison K
authors.initials: AK
authors.lastname: DeLong
authors.affiliation: Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle.
authors.forename: Marita
authors.initials: M
authors.lastname: Mann
authors.affiliation: Department of Child Health and Pediatrics, School of Medicine, College of Health Sciences, Moi University and Moi Teaching and Referral Hospital, Eldoret, Kenya.
authors.forename: Winstone M
authors.initials: WM
authors.lastname: Nyandiko
authors.affiliation: Department of Child Health and Pediatrics, School of Medicine, College of Health Sciences, Moi University and Moi Teaching and Referral Hospital, Eldoret, Kenya.
authors.forename: Samuel O
authors.initials: SO
authors.lastname: Ayaya
authors.affiliation: Center for Statistical Sciences, School of Public Health, Brown University.|Department of Biostatistics, School of Public Health, Brown University, Providence, Rhode Island.
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Hogan
authors.affiliation: Division of Infectious Diseases, Brown University Alpert Medical School, Providence, Rhode Island.
authors.forename: Rami
authors.initials: R
authors.lastname: Kantor
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D017211:Treatment Failure; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents
keywords: failure; pediatric HIV; treatment