title: The impact of insulin resistance on clinical, hormonal and metabolic parameters in lean women with polycystic ovary syndrome.
abstract: This study was performed to assess insulin resistance (IR) in lean women with polycystic ovary syndrome (PCOS). Retrospective analysis of 100 consecutive lean (body mass index <25 kg/m2) PCOS subjects was performed. Subjects were divided into two groups according to homeostasis model assessment IR index (HOMA-IR), as IR + and IR-. A HOMA-IR value >2.5 was used to indicate IR. A total of 100 lean PCOS subjects were enrolled in the study, of which 47% were insulin resistant. Comparison of group means showed significantly higher values for waist-to-hip ratio (WHR), diastolic blood pressure and Ferriman-Gallwey score (FGS) in IR + group. HOMA-IR values were found to be positively correlated with WHR (r = 0.500, p < 0.01), systolic blood pressure (r = 0.265, p < 0.01), diastolic blood pressure (r = 0.273, p < 0.01), estradiol levels (r = 0.218, p < 0.05), FGS (r = 0.456, p < 0.01) and total testosterone levels (r = 0.291, p < 0.01). When evaluating PCOS subjects, the insulin resistant group should be separated as unique and IR should also be evaluated in lean women with PCOS.
authors.affiliation: a Department of Obstetrics and Gynecology , Marmara University , Istanbul , Turkey.
authors.forename: Begum
authors.initials: B
authors.lastname: Yildizhan
authors.affiliation: a Department of Obstetrics and Gynecology , Marmara University , Istanbul , Turkey.
authors.forename: Gokce
authors.initials: G
authors.lastname: Anik Ilhan
authors.affiliation: a Department of Obstetrics and Gynecology , Marmara University , Istanbul , Turkey.
authors.forename: Tanju
authors.initials: T
authors.lastname: Pekin
mesh_terms: D000328:Adult; D001795:Blood Pressure Determination; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D012189:Retrospective Studies; D013223:Statistics as Topic; D013739:Testosterone / Q000097:blood*; D013851:Thinness / Q000175:diagnosis / Q000378:metabolism; D014421:Turkey / Q000453:epidemiology; D049629:Waist-Hip Ratio / Q000379:methods*
chemical_list: D013739:Testosterone; D004958:Estradiol
keywords: Polycystic ovary syndrome; insulin resistance; lean