title: FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy.
abstract: Evading the antitumor immune response is important for the survival and progression of cancer. Recently, we identified an unexpected role for nuclear Focal Adhesion Kinase (FAK) activity in the control of tumor Treg levels and immune evasion by regulating chemokine and cytokine transcription in cancer cells. We proposed a potentially new purpose for FAK kinase inhibitors, which can cause immune-mediated tumor regression.
authors.affiliation: Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh, UK.
authors.forename: Alan
authors.initials: A
authors.lastname: Serrels
authors.affiliation: Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh, UK.
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Frame
keywords: Cancer immunity; Focal Adhesion Kinase; checkpoint blockade; chemokine transcription; tumor microenvironment