title: Serum myostatin in central south Chinese postmenopausal women: Relationship with body composition, lipids and bone mineral density.
abstract: OBJECTIVE
  Previous data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells. The relationships between serum myostatin, body composition lipids and bone mineral density in postmenopausal women remain unclear. The aim of this study is to elucidate the relationships between serum myostatin, body composition, lipids and bone mineral density in central south Chinese postmenopausal women.
  
  
  METHODS
  A cross-sectional study was conducted in 175 healthy postmenopausal women, aged 51-75 years old. Bone mineral density (BMD) and body composition were measured by double energy X-ray absorptiometry (DXA). Serum myostatin, 25-dihydroxyvitamin D(25OH-D), parathyroid hormone (PTH), bone alkaline phosphatase (BAP) and carboxy-terminal telopeptide of type I collagen (CTX) were measured by enzyme-linked immunoabsorbent assay (ELISA).
  
  
  RESULTS
  In contrast to the osteoporotic women, the women without osteoporosis had higher BMI, fat mass and lean mass (P<0.01). The osteoporotic women were older than women without osteoporosis (P<0.01). There were no differences between two groups with regard to serum BAP, CTX, (25OH-D), PTH, lipids and myostatin after adjusted by age. BMD at each site was positively correlated with age at menopause, fat mass and lean mass, and also negatively correlated with age and serum BAP. Serum myostatin was positively correlated with tryglicerides, not correlated with either body composition or BMD at each site.
  
  
  CONCLUSIONS
  Our data indicated that serum myostatin concentration did not correlate with muscle and bone mass. Further studies are needed to demonstrate the role of myostatin in regulating the bone metabolism.
authors.affiliation: a Department of Endocrinology , Affiliated Xiaolan Hospital of Southern Medical University , Zhongshan , PR China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Ma
authors.affiliation: b Department of Clinical Laboratory , the Second Xiang-Ya Hospital, Central South University , Changsha , PR China.
authors.forename: Xianping
authors.initials: X
authors.lastname: Li
authors.affiliation: c Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital , Central South University , Changsha , PR China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: d Hospital Infection Control Center, the Second Xiang-Ya Hospital , Central South University , Changsha , PR China.
authors.forename: Yangna
authors.initials: Y
authors.lastname: Ou
authors.affiliation: c Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital , Central South University , Changsha , PR China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: c Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital , Central South University , Changsha , PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.affiliation: c Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital , Central South University , Changsha , PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.affiliation: c Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital , Central South University , Changsha , PR China.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Sheng
authors.affiliation: c Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital , Central South University , Changsha , PR China.
authors.forename: Eryuan
authors.initials: E
authors.lastname: Liao
mesh_terms: D000368:Aged; D001823:Body Composition; D015519:Bone Density; D002681:China; D003430:Cross-Sectional Studies; D006801:Humans; D008875:Middle Aged; D055435:Myostatin / Q000097:blood*; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D017698:Postmenopause / Q000097:blood*
chemical_list: C525911:MSTN protein, human; D055435:Myostatin
keywords: Body composition; bone mineral density; myostatin; postmenopausal women