title: C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC.
abstract: For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories (Liu et al., 2016; Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.
authors.affiliation: Brain Science Institute, Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
authors.forename: Lindsey R
authors.initials: LR
authors.lastname: Hayes
authors.affiliation: Brain Science Institute, Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: jrothstein@jhmi.edu.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Rothstein
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D000818:Animals; D000073885:C9orf72 Protein; D042622:DNA Repeat Expansion / Q000235:genetics*; D004195:Disease Models, Animal; D057180:Frontotemporal Dementia / Q000235:genetics*; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans
chemical_list: D000073885:C9orf72 Protein; C000606498:C9orf72 protein, mouse; D020662:Guanine Nucleotide Exchange Factors