title: Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report.
abstract: A 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As2O3), conventional chemotherapy, and autologous peripheral blood stem cell transplantation. We attempted to use both tamibarotene and As2O3 as a combination therapy, and he achieved molecular complete remission. Grade 2 prolongation of the QTc interval on the electrocardiogram was observed during the therapy. The combination therapy of As2O3 and tamibarotene may be effective and tolerable for treating refractory APL cases who have no treatment options, even when they have previously been treated with tamibarotene and As2O3 as a single agent.
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan; Department of Hematology, Ebina General Hospital, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Kojima
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ogiya
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Ichiki
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Ryujiro
authors.initials: R
authors.lastname: Hara
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan; Department of Hematology, Ebina General Hospital, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Amaki
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Kawai
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Numata
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Sato
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Mitsuki
authors.initials: M
authors.lastname: Miyamoto
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan; Division of Internal Medicine, Hadano Red Cross Hospital, Japan.
authors.forename: Rikio
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Machida
authors.affiliation: Department of laboratory Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Matsushita
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawada
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ando