title: BC200 LncRNA a potential predictive marker of poor prognosis in esophageal squamous cell carcinoma patients.
abstract: OBJECTIVE
  To explore the expression and prognosis significance of BC200 in esophageal squamous cell carcinoma (ESCC) patients who received radical resection.
  
  
  METHODS
  We used quantitative real-time polymerase chain reaction to detect the expression level of BC200 in cancer tissue and paired adjacent normal tissue samples from 70 ESCC patients who received radical surgical resection and analyzed the correlation of the relative expression level of BC200 with clinical-pathological features and prognosis.
  
  
  RESULTS
  We found that the relative expression of BC200 was significantly higher in ESCC tissues compared with adjacent normal tissue samples (P=0.023). But the expression of BC200 were not related to clinical-pathological features, such as age, TNM stages, and histological grade (P>0.05). Kaplan-Meier analysis showed that high expression levels of BC200 were correlated with poor prognosis in ESCC patients. Patients with a high level of BC200 had a shorter disease-free survival and overall survival than those with low BC200 expression (P=0.034 and P=0.031, respectively). On multivariate analysis, the hazard ratio (HR) of BC200 expression was 2.17 (95% confidence interval [CI]=1.12-4.19, P=0.022) for disease-free survival and 2.24 (95% CI=1.12-4.49, P=0.023) for overall survival.
  
  
  CONCLUSIONS
  Our results indicate that high expression of BC200 reflects poor prognosis and could serve as a novel predictive marker for ESCC patients who received radical resection.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors.forename: Cai-Hua
authors.initials: CH
authors.lastname: Zhu
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors.forename: Xiang-Ke
authors.initials: XK
authors.lastname: Li
authors.affiliation: Department of Translational Medicine Center, Zhengzhou Center Hospital, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zong
authors.affiliation: Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China; Department of Digestive Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors.forename: Xin-Guang
authors.initials: XG
authors.lastname: Cao
authors.affiliation: Oncology Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Hu
keywords: BC200; esophageal squamous cell carcinoma; long noncoding RNAs; poor prognosis; predictive marker