title: Tuning of Copper-Catalyzed Multicomponent Reactions toward 3-Functionalized Oxindoles.
abstract: A tunable copper-catalyzed azide-alkyne cycloaddition (CuAAC)-initiated multicomponent reaction strategy for the construction of 3-functionalized indolin-2-ones is reported. Upon controlling the ring opening of four-membered O-heterocyclic intermediates, this unique method enables the divergent derivatization of N-protected isatins to give three-component (3-CR) and four-component (4-CR) adducts, respectively.
authors.affiliation: Department of Chemistry, Zhejiang University , 20 Yugu Road, Hangzhou 310027, China.|School of Chemistry and Materials Engineering, Chaohu University , Chaohu 238000, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, Zhejiang University , 20 Yugu Road, Hangzhou 310027, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ling
authors.affiliation: Department of Chemistry, Zhejiang University , 20 Yugu Road, Hangzhou 310027, China.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Chemistry, Zhejiang University , 20 Yugu Road, Hangzhou 310027, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ma