title: Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasis.
abstract: Transforming growth factor-β (TGF-β) signaling pathway is a key regulator of various cancer biologies, including cancer cell migration, invasion, angiogenesis, proliferation, as well as apoptosis, and it is one of indispensable signaling pathways during cancer metastasis. TGF-β signaling pathway can regulate and be regulated by a series of molecular and signaling pathways where microRNAs (miRNAs) seem to play important roles. miRNAs are small non-coding RNAs that can regulate expressions of their target genes. Emerging evidence suggest that miRNAs participate in various biological and pathologic processes such as cancer cells apoptosis, proliferation, invasion, migration, and metastasis by influencing multiple signaling pathways. In this article, we focus on the interaction between miRNAs and TGF-β in breast cancer (BC) metastasis through modulating invasion-metastasis-related factors, including epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), matrix metalloproteinase (MMP), tissue inhibitors of MMPs (TIMPs), cell adhesion molecules (CAMs), and tumor microenvironment (TME). Through a clear understanding of the complicated links between TGF-β pathway and miRNAs, it may provide a novel and safer therapeutic target to prevent BC metastasis.
authors.affiliation: Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.|The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
authors.forename: Siying
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Huaian Second People's Hospital, Huaian, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Mao
authors.affiliation: Xuzhou Medical College, Xuzhou, Jiangsu, China.|Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Heda
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Cancer Institute of Jiangsu Province, 42 Bai Zi Ting Road, Nanjing, Jiangsu, 210000, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Sun
authors.affiliation: Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Cancer Institute of Jiangsu Province, 42 Bai Zi Ting Road, Nanjing, Jiangsu, 210000, China.
authors.forename: Junying
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: JIan
authors.initials: J
authors.lastname: Li
authors.affiliation: Xuzhou Medical College, Xuzhou, Jiangsu, China. jhtang_professor@126.com.|Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Cancer Institute of Jiangsu Province, 42 Bai Zi Ting Road, Nanjing, Jiangsu, 210000, China. jhtang_professor@126.com.
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology; D035683:MicroRNAs / Q000235:genetics*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology*; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs; D009363:Neoplasm Proteins; D019714:Tissue Inhibitor of Metalloproteinases; D016212:Transforming Growth Factor beta; D020782:Matrix Metalloproteinases
keywords: Breast cancer; Metastasis; TGF-β pathway; Therapy; miRNAs