title: CEA Level, Radical Surgery, CD56 and CgA Expression Are Prognostic Factors for Patients With Locoregional Gastrin-Independent GNET.
abstract: Gastrin-independent gastric neuroendocrine tumors (GNETs) are highly malignant. Radical resections and lymphadenectomy are considered to be the only possible curative treatment for these tumors. However, the prognosis of gastrin-independent GNETs is not well defined. In this study, we identified prognostic factors of locoregional gastrin-independent GNETs.All patients diagnosed with locoregional gastrin-independent GNETs between 2000 and 2014 were included in this retrospective study. Clinical characteristics, blood tests, pathological characteristics, treatments, and follow-up data of the patients were collected and analyzed.Of the 66 patients diagnosed with locoregional gastrin-independent GNETs, 57 (86.4%) received radical resections, 7 (10.6%) with palliative resection, 1 (1.5%) with gastrojejunostomy, and 1 (1.5%) with exploration surgeries. The median survival time for these patients was 19.0 months (interquartile range, 11.0-38.0). The 1-, 3-, and 5-year survival rates were 72%, 34%, and 28%, respectively. Multivariate analysis indicated that carcinoembryonic antigen (CEA) level (P = 0.04), radical resection (P = 0.04), and positive Cluster of Differentiation 56 (CD56) expression (P = 0.016) were significant prognostic factors on overall survival rate. Further univariate and multivariate analysis of 57 patients who received radical resections found that CgA expression (P = 0.35) and CEA level (P = 0.33) are independent prognostic factors.Gastrin-independent GNETs had poor prognosis. Serum CEA level, radical surgery, CD56 and CgA expression are markers to evaluate the survival of patients with locoregional gastrin-independent GNETs.
authors.affiliation: From the Department of Abdominal Surgery (YL, XB, Jianjun Zhao, ZH, Jianguo Zhou, ZL, YZ, ML, XC, XH, DZ, HZ, JC); and Department of Medical Oncology (YC), Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China .
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Xinyu
authors.initials: X
authors.lastname: Bi
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Li
authors.forename: Yefan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Muxing
authors.initials: M
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.forename: Xuhui
authors.initials: X
authors.lastname: Hu
authors.forename: Yihebali
authors.initials: Y
authors.lastname: Chi
authors.forename: Dongbing
authors.initials: D
authors.lastname: Zhao
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Cai
mesh_terms: D019002:CD56 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D053379:Chromogranin A / Q000097:blood*; D005260:Female; D005743:Gastrectomy; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D011379:Prognosis; D016016:Proportional Hazards Models; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D016019:Survival Analysis
chemical_list: D019002:CD56 Antigen; D002272:Carcinoembryonic Antigen; D053379:Chromogranin A; D005755:Gastrins; C522918:NCAM1 protein, human