title: Serum of 25-Hydroxyvitamin D and Intact Parathyroid Hormone Levels in Postmenopausal Women with Hip and Upper Limb Fractures.
abstract: To assess the serum of 25-hydroxyvitamin D (25(OH)D) and intact parathyroid hormone (iPTH) levels in postmenopausal women from northern China with hip and upper limb fractures.
  
  
  
  Case-control.
  
  
  
  Affiliated Hospital of Qingdao University.
  
  
  
  Postmenopausal women diagnosed with hip fracture (n = 335) and matched controls without fracture (n = 335).
  
  
  
  Between 2011 and 2013, fasting venous samples were analyzed for 25(OH)D, iPTH, alkaline phosphatase (ALP), calcium, and phosphorus. All women completed a standardized questionnaire designed to document putative risk factors for fractures.
  
  
  
  Eight percent of participants had vitamin D deficiency, and 66.0% had secondary hyperparathyroidism. Serum 25(OH)D levels were significantly (P < .001) lower in women with hip fracture than in controls. Multivariate logistic regression analysis adjusted for common risk factors showed that serum 25(OH)D of 20 ng/mL or less was an independent indicator of hip fracture (odds ratio (OR) = 2.98, 95% confidence interval (CI) = 2.11-4.20) and concomitant upper limb fracture in those with existing hip fractures (OR = 4.77, 95% CI = 1.60-10.12). The area under the receiver operating characteristic curve of 25(OH)D was 0.77 (95% CI = 0.68-0.84) for hip fracture and 0.80 (95% CI = 0.72-0.89) for hip and upper limb fractures.
  
  
  
  Vitamin D insufficiency and secondary hyperparathyroidism were a common problem in postmenopausal women who presented with concomitant hip and upper limb fractures, suggesting that they might contribute to the pathophysiology of fractures in postmenopausal women.
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
authors.forename: Jiang-Tao
authors.initials: JT
authors.lastname: Lv
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
authors.forename: Shao-Qi
authors.initials: SQ
authors.lastname: Tian
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001134:Arm Injuries / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology*; D006620:Hip Fractures / Q000453:epidemiology*; D006801:Humans; D006961:Hyperparathyroidism / Q000453:epidemiology; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D017698:Postmenopause; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology*
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: 25-hydroxyvitamin D; hip fracture; intact parathyroid hormone; postmenopausal; upper limb fracture