title: Comparison of high-resolution T1W 3D GRE (LAVA) with 2-point Dixon fat/water separation (FLEX) to T1W fast spin echo (FSE) in prostate cancer (PCa).
abstract: OBJECTIVE
  To compare T1-weighted (T1W) fast spin echo (FSE) to T1W 3-dimensional gradient recalled echo (LAVA) with fat water separation (FLEX) in prostate cancer (PCa).
  
  
  METHODS
  With institutional review board waiver, 39 patients underwent 3-T magnetic resonance imaging including T1W LAVA FLEX (157s)/T1W FSE (316s). Two radiologists assessed (a) image quality/sharpness, (b) presence/severity of artifacts, and (c) skeletal (N=22)/nodal (N=9) metastases. Results were compared using Wilcoxon signed-rank test/receiver operator characteristic analysis.
  
  
  RESULTS
  With T1W LAVA FLEX, image quality/sharpness improved (P<.001) with less motion (P=.002-.03) and no difference in phase-encoding artifact (P>.05). One patient had moderate fat/water swap. Detection of skeletal metastases was unchanged (P>.05) and nodal metastases either improved (P=.002) or were comparable (P=.16) using T1W LAVA FLEX.
  
  
  CONCLUSIONS
  T1W LAVA FLEX improves image quality, lessens motion artifact, and is comparable or improves detection of metastases in PCa with reduction in acquisition time.
authors.affiliation: Department of Diagnostic Imaging, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON, Canada K1Y 4E9.
authors.forename: Karim
authors.initials: K
authors.lastname: Samji
authors.affiliation: Department of Diagnostic Imaging, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON, Canada K1Y 4E9.
authors.forename: Abdulmohsen
authors.initials: A
authors.lastname: Alrashed
authors.affiliation: Department of Diagnostic Imaging, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON, Canada K1Y 4E9.
authors.forename: Wael M
authors.initials: WM
authors.lastname: Shabana
authors.affiliation: Department of Diagnostic Imaging, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON, Canada K1Y 4E9.
authors.forename: Matthew Df
authors.initials: MD
authors.lastname: McInnes
authors.affiliation: Global MR Applications and Workflow, GE Healthcare, Houston, TX, USA.
authors.forename: Ersin
authors.initials: E
authors.lastname: Bayram
authors.affiliation: Department of Diagnostic Imaging, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON, Canada K1Y 4E9. Electronic address: nschieda@toh.on.ca.
authors.forename: Nicola
authors.initials: N
authors.lastname: Schieda
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D016477:Artifacts; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009038:Motion; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012372:ROC Curve; D014867:Water
chemical_list: D014867:Water
keywords: Dixon; Prostate cancer; T1-weighted imaging; magnetic resonance imaging MRI; metastases