title: Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea.
abstract: Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular morbidity and death. Little information is available regarding the relationship between the severity of OSA and myocardial performance in OSA patients who have normal ejection fractions. We prospectively investigated this relationship, using the tissue-Doppler myocardial performance index (TD-MPI). We conducted overnight, full-laboratory polysomnographic examinations of 116 patients, and calculated the left and right ventricular TD-MPIs. Patients were classified into 3 groups in accordance with their apnea-hypopnea index (AHI) levels: AHImild (≥5 to <15), AHImoderate (≥15 to <30), and AHIsevere (≥30). Left and right ventricular TD-MPI values were higher in the AHIsevere group than in the AHImild and AHImoderate groups (all P <0.05). In addition, right ventricular TD-MPI values in the AHImoderate group were higher than those in the AHImild group (P <0.05). Right ventricular TD-MPI was significantly associated with AHI (β=0.468, P <0.001), left ventricular TD-MPI, and right ventricular early-to-late filling velocities (E/A ratio) in multiple linear regression analysis. On the other hand, left ventricular TD-MPI was significantly associated with right ventricular TD-MPI and left ventricular E/A ratio (both P <0.05). Our results show that OSA severity, determined by means of AHI, is independently associated with impaired right and left ventricular function as indicated by TD-MPI in patients who have OSA and normal ejection fractions.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Akyol
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cortuk
authors.forename: Ahmet Oytun
authors.initials: AO
authors.lastname: Baykan
authors.forename: Kemal
authors.initials: K
authors.lastname: Kiraz
authors.forename: Abdurrezzak
authors.initials: A
authors.lastname: Borekci
authors.forename: Taner
authors.initials: T
authors.lastname: Seker
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gur
authors.forename: Murat
authors.initials: M
authors.lastname: Cayli
mesh_terms: D000328:Adult; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D017286:Polysomnography; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D015996:Survival Rate / Q000639:trends; D014421:Turkey / Q000453:epidemiology; D018754:Ventricular Dysfunction / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016276:Ventricular Function / Q000502:physiology*
keywords: Cardiovascular diseases/etiology; echocardiography, Doppler; heart-function tests/methods; predictive value of tests; prospective studies; risk factors; sleep apnea, obstructive/classification/complications/physiopathology; ventricular dysfunction, left/diagnosis/etiology/physiology; ventricular dysfunction, right/diagnosis/etiology/physiology