title: Biomedical monitoring of phosphate removal by hemodialysis.
abstract: A compact flow analysis system for non-invasive, dialysate-side monitoring of phosphate removal in the course of clinical hemodialysis treatment is presented. The monitor is based on solenoid operated micro-pumps and extremely cheap optoelectronic flow-through detector allowing photometric determination of phosphate in spent dialysate using a molybdenum blue method. The monitor can operate in both, discrete and continuous modes of measurement. The analytical utility of monitor has been tested with samples of spent dialysate produced by artificial kidney in the course of real hemodialysis sessions. The results of monitoring are comparable with those obtained using reference off-line method recommended for clinical analysis. Additionally, the possibility of two-side (dialysate and blood) monitoring of hemodialysis treatments with optoelectronic flow-through detectors has been announced.
authors.affiliation: University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, Poland; University of Warsaw, MISMaP College, Banacha 2C, 02-097 Warsaw, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Michalec
authors.affiliation: University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Fiedoruk-Pogrebniak
authors.affiliation: Medical University of Warsaw, Department of Nephrology, Banacha 1, 02-097 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Matuszkiewicz-Rowińska
authors.affiliation: University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Tymecki
authors.affiliation: University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, Poland. Electronic address: rkoncki@chem.uw.edu.pl.
authors.forename: Robert
authors.initials: R
authors.lastname: Koncki
mesh_terms: D015314:Dialysis Solutions / Q000032:analysis*; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry; D008982:Molybdenum / Q000737:chemistry; D010710:Phosphates / Q000032:analysis*; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D015314:Dialysis Solutions; D007202:Indicators and Reagents; D010710:Phosphates; C017541:molybdenum blue; D008982:Molybdenum
keywords: Hemodialysis; Monitoring; Optoelectronic detector; Phosphate