title: Laboratory markers has many valuable parameters in the discrimination between acute appendicitis and renal colic.
abstract: BACKGROUND
  Only one diagnostic parameter is not available for acute appendicitis. For the establishment of diagnosis, combination of medical history, clinical, laboratory tests, and radiological imaging modalities are used so as to decrease the rates of negative laparotomy and morbidity secondary to delay in diagnosis. Thepresent study aimed to determine haematological and inflammatory markers which will be used in the discrimination of acute appendicitis (AA) and renal colic which are the most frequent and indistinguishable causes of abdominal pain in patients applying to the emergency service.
  
  
  METHODS
  A total of 215 patients who presented with abdominal pain and who were histopathologically diagnosed as AA, and 200 patients who presented with abdominal pain and who were diagnosed as renal colic were included into the study. Control group consisted of 61 patients without any complaints who came to the outpatient clinics of internal medicine only for blood counts. Analyzed blood samples were WBC, RDW, Hb, MCV, MPV, neutrophil, lymphocyte, NLR and PLR. All differences associated with a chance probability of.05 or less were considered statistically significant.
  
  
  RESULTS
  A statistically significant intergroup difference was seen between AA and renal colic groups as for age, WBC, Hb, MCV, neutrophil, lymphocyte, NLR and PLR. A statistically significant intergroup difference was seen between AA and control groups regarding age, WBC, Hb, RDW, MPV, neutrophil, lymphocyte, NLR and PLR. A statistically significant intergroup difference was seen between renal colic and control groups as for age, WBC, RDW, MPV, neutrophil and NLR. In ROC curve analysis, the area under AUCs for WBC, neutrophil, NLR and PLR were 0.896, 0.916, 0.888 and 0.725, respectively (p≤0.05).
  
  
  CONCLUSIONS
  In the discrimination between patients with renal colic and those without any illness, WBC, RDW, MPV, neutrophil and NLR; in the differentiation between the patients with AA and healthy individuals, WBC, RDW, MPV, neutrophil, lymphocyte, NLR and PLR; and more importantly in the discrimination between patients with AA and those with renal colic who presented to emergency services with abdominal pain WBC, neutrophil, lymphocyte, PLR and NLR can be useful parameters.
authors.affiliation: Department of Emergency Medicine, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey. dr.ethemacar@hotmail.com.
authors.forename: Ethem
authors.initials: E
authors.lastname: Acar
authors.affiliation: Department of General Surgery, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: Önder
authors.initials: Ö
authors.lastname: Özcan
authors.affiliation: Department of Urology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Deliktaş
authors.affiliation: Department of Emergency Medicine, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Beydilli
authors.affiliation: Department of Internal Medicine, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Kırlı
authors.affiliation: Department of Emergency Medicine, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: Ömer Doğan
authors.initials: ÖD
authors.lastname: Alataş
authors.affiliation: Department of Internal Medicine, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Şahin
authors.affiliation: Department of Emergency Medicine, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: Birdal
authors.initials: B
authors.lastname: Yıldırım
authors.affiliation: Department of General Surgery, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
authors.forename: Ahmet Korkut
authors.initials: AK
authors.lastname: Belli
mesh_terms: D000328:Adult; D001064:Appendicitis / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008214:Lymphocytes; D008297:Male; D009504:Neutrophils; D012372:ROC Curve; D056844:Renal Colic / Q000097:blood / Q000175:diagnosis*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers