title: Regulating the construction and demolition of the synaptonemal complex.
abstract: The synaptonemal complex (SC) is a meiosis-specific scaffold that links homologous chromosomes from end to end during meiotic prophase and is required for the formation of meiotic crossovers. Assembly of SC components is regulated by a combination of associated nonstructural proteins and post-translational modifications, such as SUMOylation, which together coordinate the timing between homologous chromosome pairing, double-strand-break formation and recombination. In addition, transcriptional and translational control mechanisms ensure the timely disassembly of the SC after crossover resolution and before chromosome segregation at anaphase I.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, USA.
authors.forename: Cori K
authors.initials: CK
authors.lastname: Cahoon
authors.affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, USA.|Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: R Scott
authors.initials: RS
authors.lastname: Hawley
mesh_terms: D000818:Animals; D023902:Chromosome Pairing; D020090:Chromosome Segregation; D006801:Humans; D008540:Meiosis; D011499:Protein Processing, Post-Translational; D013573:Synaptonemal Complex / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure