title: Porous antioxidant polymer microparticles as therapeutic systems for the airway inflammatory diseases.
abstract: Inhaling steroidal anti-inflammatory drugs is the most common treatment for airway inflammatory diseases such as asthma. However, frequent steroid administration causes adverse side effects. Therefore, the successful clinical translation of numerous steroidal drugs greatly needs pulmonary drug delivery systems which are formulated from biocompatible and non-immunogenic polymers. We have recently developed a new family of biodegradable polymer, vanillyl alcohol-containing copolyoxalate (PVAX) which is able to scavenge hydrogen peroxide and exert potent antioxidant and anti-inflammatory activity. In this work, we report the therapeutic potential of porous PVAX microparticles which encapsulate dexamethasone (DEX) as a therapeutic system for airway inflammatory diseases. PVAX microparticles themselves reduced oxidative stress and suppressed the expression of pro-inflammatory tumor necrosis factor-alpha and inducible nitric oxide synthase in the lung of ovalbumin-challenged asthmatic mice. However, DEX-loaded porous PVAX microparticles showed significantly enhanced therapeutic effects than PVAX microparticles, suggesting the synergistic effects of PVAX with DEX. In addition, PVAX microparticles showed no inflammatory responses to lung tissues. Given their excellent biocompatibility and intrinsic antioxidant and anti-inflammatory activity, PVAX microparticles hold tremendous potential as therapeutic systems for the treatment of airway inflammatory diseases such as asthma.
authors.affiliation: Department of BIN Convergence Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea.
authors.forename: Dahee
authors.initials: D
authors.lastname: Jeong
authors.affiliation: Department of BIN Convergence Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea.
authors.forename: Changsun
authors.initials: C
authors.lastname: Kang
authors.affiliation: Department of BIN Convergence Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea.
authors.forename: Eunkyeong
authors.initials: E
authors.lastname: Jung
authors.affiliation: Department of BIN Convergence Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea.
authors.forename: Donghyuck
authors.initials: D
authors.lastname: Yoo
authors.affiliation: Department of BIN Convergence Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of BIN Convergence Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea; Department of Polymer⋅Nano Science and Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea. Electronic address: dlee@chonbuk.ac.kr.
authors.forename: Dongwon
authors.initials: D
authors.lastname: Lee
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001592:Benzyl Alcohols / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003907:Dexamethasone / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D065546:Drug Liberation; D008168:Lung / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D016062:Porosity; D000067996:RAW 264.7 Cells; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000485:Allergens; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001592:Benzyl Alcohols; D011108:Polymers; D014409:Tumor Necrosis Factor-alpha; D003907:Dexamethasone; D010047:Ovalbumin; C024078:vanillyl alcohol
keywords: Airway inflammation; Antioxidant; Biodegradable polymer; Hydrogen peroxide; Porous particles