title: Effect of Headgroups on Small-Ion Permeability across Archaea-Inspired Tetraether Lipid Membranes.
abstract: This paper examines the effects of four different polar headgroups on small-ion membrane permeability from liposomes comprised of Archaea-inspired glycerolmonoalkyl glycerol tetraether (GMGT) lipids. We found that the membrane-leakage rate across GMGT lipid membranes varied by a factor of ≤1.6 as a function of headgroup structure. However, the leakage rates of small ions across membranes comprised of commercial bilayer-forming 1-palmitoyl-2-oleoyl-sn-glycerol (PO) lipids varied by as much as 32-fold within the same series of headgroups. These results demonstrate that membrane leakage from GMGT lipids is less influenced by headgroup structure, making it possible to tailor the structure of the polar headgroups on GMGT lipids while retaining predictable leakage properties of membranes comprised of these tethered lipids.
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093-0358, USA.
authors.forename: Takaoki
authors.initials: T
authors.lastname: Koyanagi
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093-0358, USA.
authors.forename: Geoffray
authors.initials: G
authors.lastname: Leriche
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093-0358, USA.
authors.forename: Alvin
authors.initials: A
authors.lastname: Yep
authors.affiliation: Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, 92182-1030, USA.
authors.forename: David
authors.initials: D
authors.lastname: Onofrei
authors.affiliation: Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, 92182-1030, USA.
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Holland
authors.affiliation: Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700, Fribourg, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Mayer
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093-0358, USA. jerryyang@ucsd.edu.
authors.forename: Jerry
authors.identifier: 0000-0002-8423-7376
authors.initials: J
authors.lastname: Yang
mesh_terms: D001105:Archaea / Q000378:metabolism*; D004075:Diglycerides / Q000737:chemistry; D000067493:Dynamic Light Scattering; D005452:Fluoresceins / Q000737:chemistry / Q000378:metabolism; D007477:Ions / Q000737:chemistry / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D008563:Membrane Lipids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D010713:Phosphatidylcholines; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D004075:Diglycerides; D005452:Fluoresceins; D007477:Ions; D008081:Liposomes; D008563:Membrane Lipids; D010713:Phosphatidylcholines; C083975:1-palmitoyl-2-oleoyl-sn-glycerol; C024098:6-carboxyfluorescein; C028694:1-palmitoyl-2-oleoylphosphatidylcholine
keywords: archaea; biomimetic; lipids; membranes; synthetic lipid