title: [Clinical pharmacist influence at hospital to prevent overdosed prescription of acetaminophen].
abstract: OBJECTIVE
  The recommended daily dose of acetaminophen is limited to 60mg/kg/day with a maximum of 3g daily dose in adults weighing less than 50kg or in patients undergoing certain risk factors. This study aimed at assessing the fulfillment of those recommendations and the possible impact on the liver dysfunction at supra-therapeutic doses of acetaminophen.
  
  
  METHODS
  This study was performed one day in 9 services. Patients characteristics, acetaminophen dose, daily dose administered, physiopathological aspects, markers of liver damage were collected.
  
  
  RESULTS
  Among 542 prescriptions analyzed, 343 of them contained acetaminophen. The median age of patients studied was 81 years and one third weighed less than 50kg. The main risk factor of supra-therapeutic prescriptions was the lack of dose acetaminophen based on weight with 14% patients concerned and this risk raised at 17% when the pathophysiological conditions were included. The presence of pharmacists in medicals departments was more effective than the use of informatics programs limiting the dose systematically to 3g/day, or a distant pharmaceutical validation from care services to reduce the risk of acetaminophen overdose. According to the statement of administrations, only 4 of 49 patients received doses above 60mg/kg/day with a low impact on liver function tests.
  
  
  CONCLUSIONS
  The continuous presence in pharmaceutical care services was the most effective measure to ensure effective implementation of acetaminophen recommendations.
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address: florent.viguier@aphp.fr.
authors.forename: F
authors.initials: F
authors.lastname: Viguier
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: C
authors.initials: C
authors.lastname: Roessle
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: L
authors.initials: L
authors.lastname: Zerhouni
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: A
authors.initials: A
authors.lastname: Rouleau
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: C
authors.initials: C
authors.lastname: Benmelouka
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: A
authors.initials: A
authors.lastname: Chevallier
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: F
authors.initials: F
authors.lastname: Chast
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: O
authors.initials: O
authors.lastname: Conort
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D062787:Drug Overdose / Q000517:prevention & control*; D011307:Drug Prescriptions; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D010595:Pharmacists; D010607:Pharmacy Service, Hospital; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen
keywords: Acetaminophen; Audit; Bon usage du médicament; Clinical pharmacist; Drug safety; Guidelines; Intervention pharmaceutique; Paracétamol; Pharmaceutical interventions; Pharmacien clinicien; Posologie supra-thérapeutique; Supra-therapeutic dosing of acetaminophen