title: Effects of female and male body mass indices on the treatment outcomes and neonatal birth weights associated with in vitro fertilization/intracytoplasmic sperm injection treatment in China.
abstract: OBJECTIVE
  To investigate the combined effects of Chinese couples' body mass indices (BMIs) on the outcomes of IVF or intracytoplasmic sperm injection (ICSI) and the clinical characteristics of their neonates.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-affiliated reproductive medicine center.
  
  
  METHODS
  A total of 12,061 first fresh IVF/ICSI cycles with autologous oocytes from September 1, 2009 to December 31, 2014.
  
  
  METHODS
  None.
  
  
  METHODS
  The primary treatment outcome was live birth, and the primary outcome for the neonates was neonatal birth weight (NBW).
  
  
  RESULTS
  After adjusting for confounders, our study showed that in IVF cycles, couples with a female BMI ≥25 kg/m(2) had a significantly higher odds of abortion and a significantly lower odds of live birth than couples with both male and female BMIs <25 kg/m(2). Regarding ICSI cycles, no significant relationship was found between the couples' BMIs and the live birth rate. The NBWs of singletons conceived via IVF/ICSI cycles was significantly higher when their parents' BMIs were greater; however, no significant differences were observed in the NBWs of twins conceived via IVF/ICSI cycles.
  
  
  CONCLUSIONS
  Increased female BMI negatively affected live births conceived via IVF. Regarding ICSI, no significant differences were found in the outcomes in terms of parental BMI. The singleton neonates' NBWs increased with parental BMI conceived via IVF/ICSI. However, parental BMI did not significantly affect the NBWs of twins conceived via IVF/ICSI.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Reproductive Medicine Center, Hainan Provincial Nongken General Hospital, Haikou, People's Republic of China.
authors.forename: Jiayuan
authors.initials: J
authors.lastname: Hao
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Fuli
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Kong
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. Electronic address: 13613863710@163.com.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000046:Academic Medical Centers; D001724:Birth Weight; D015992:Body Mass Index; D016009:Chi-Square Distribution; D002681:China; D005220:Fathers; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D016015:Logistic Models; D008297:Male; D009035:Mothers; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D018873:Pregnancy Rate; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D016896:Treatment Outcome
keywords: Body mass index; intracytoplasmic sperm injection; in vitro fertilization; live birth; neonatal birth weight