title: Resting and exercise energy metabolism in weight-reduced adults with severe obesity.
abstract: To determine effects of physical activity (PA) with diet-induced weight loss on energy metabolism in adults with severe obesity.
  
  
  
  Adults with severe obesity (n = 11) were studied across 6 months of intervention, then compared with controls with less severe obesity (n = 7) or normal weight (n = 9). Indirect calorimetry measured energy metabolism during exercise and rest. Markers of muscle oxidation were determined by immunohistochemistry. Data were presented as medians.
  
  
  
  The intervention induced 7% weight loss (P = 0.001) and increased vigorous PA by 24 min/wk (P = 0.02). During exercise, energy expenditure decreased, efficiency increased (P ≤ 0.03), and fatty acid oxidation (FAO) did not change. Succinate dehydrogenase increased (P = 0.001), but fiber type remained the same. Post-intervention subjects' resting metabolism remained similar to controls. Efficiency was lower in post-intervention subjects compared with normal-weight controls exercising at 25 W (P ≤ 0.002) and compared with all controls exercising at 60% VO2peak (P ≤ 0.019). Resting and exercise FAO of post-intervention subjects remained similar to adults with less severe obesity. Succinate dehydrogenase and fiber type were similar across all body weight statuses.
  
  
  
  While metabolic adaptations to PA during weight loss occur in adults with severe obesity, FAO does not change. Resulting FAO during rest and exercise remains similar to adults with less severe obesity.
authors.affiliation: Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Kazanna C
authors.initials: KC
authors.lastname: Hames
authors.affiliation: Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Florida Hospital, Translational Research Institute for Metabolism and Diabetes, Orlando, Florida, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Coen
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Wendy C
authors.initials: WC
authors.lastname: King
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Anthony
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Maja
authors.initials: M
authors.lastname: Stefanovic-Racic
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Frederico G S
authors.initials: FG
authors.lastname: Toledo
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Jolene B
authors.initials: JB
authors.lastname: Lowery
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Helbling
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Dubé
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: James P
authors.initials: JP
authors.lastname: DeLany
authors.affiliation: Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Jakicic
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Florida Hospital, Translational Research Institute for Metabolism and Diabetes, Orlando, Florida, USA.
authors.forename: Bret H
authors.initials: BH
authors.lastname: Goodpaster
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001481:Basal Metabolism; D001823:Body Composition; D015992:Body Mass Index; D002153:Calorimetry, Indirect; D003430:Cross-Sectional Studies; D004038:Diet, Reducing; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D009767:Obesity, Morbid / Q000628:therapy*; D010084:Oxidation-Reduction; D015431:Weight Loss