title: Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity.
abstract: OBJECTIVE
  To determine the association between overweight/obesity in schoolchildren with FTO rs9939609 polymorphism (fatmass and obesity associated) and family history of obesity.
  
  
  METHODS
  Cross-sectional study comprising a sample of 406 children aged 7-17 years in a city in southern Brazil. Overweight/obesity in schoolchildren was assessed by body mass index (BMI), and family history of obesity was self-reported by parents. Polymorphism genotyping was performed by real time PCR (polymerase chain reaction). The association between the nutritional status of schoolchildren with the presence of family obesity, stratified by polymorphism genotypes (AA [at-risk for obesity], AT, and TT), was assessed by prevalence ratio values (PR) through Poisson regression.
  
  
  RESULTS
  Among schoolchildren with the AA genotype, 57.4% had overweight/obesity; the percentage was lower for the AT and TT genotypes (33.1% and 28.9%, respectively). Overweight/obesity in schoolchildren was associated with a family history of obesity, especially among children with the AA genotype. The prevalence was higher among those with an obese mother (PR: 1.28; p<0.001), obese maternal or paternal grandmother (PR: 1.22; p=0.047), and obese paternal grandfather (PR: 1.32; p<0.001).
  
  
  CONCLUSIONS
  There is an association between the AA genotype of rs9939609 polymorphism and BMI among schoolchildren. The association between overweight/obesity in schoolchildren with a family history of obesity was found mainly among students with the AA genotype.
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil. Electronic address: cezanereuter@unisc.br.
authors.forename: Cézane Priscila
authors.initials: CP
authors.lastname: Reuter
authors.affiliation: Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil.
authors.forename: Miria Suzana
authors.initials: MS
authors.lastname: Burgos
authors.affiliation: Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil.
authors.forename: Joana Carolina
authors.initials: JC
authors.lastname: Bernhard
authors.affiliation: Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil.
authors.forename: Debora
authors.initials: D
authors.lastname: Tornquist
authors.affiliation: Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil.
authors.forename: Elisa Inês
authors.initials: EI
authors.lastname: Klinger
authors.affiliation: Universidade Luterana do Brasil, Canoas, RS, Brazil.
authors.forename: Tássia Silvana
authors.initials: TS
authors.lastname: Borges
authors.affiliation: Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil.
authors.forename: Jane Dagmar Pollo
authors.initials: JD
authors.lastname: Renner
authors.affiliation: Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil.
authors.forename: Andréia Rosane
authors.initials: AR
authors.lastname: de Moura Valim
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Elza Daniel
authors.initials: ED
authors.lastname: de Mello
mesh_terms: D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D015992:Body Mass Index; D001938:Brazil; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D009752:Nutritional Status / Q000235:genetics; D050177:Overweight / Q000235:genetics*; D063766:Pediatric Obesity / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Adolescent; Adolescente; Child; Criança; Genetic; Genética; Obesidade; Obesity