title: Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits.
abstract: BACKGROUND
  Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions. Furthermore, there has been a noticeable increase in microorganisms resistant to these preparations. Mucoadhesive buccal films represent a modern therapeutic system for the treatment of oral mucosal fungal infection paired with a high degree of patient compliance. Ciclopirox olamine applied directly onto the oral mucosa offers an attractive alternative to treatment with systemic antifungals thanks to its low incidence of resistance and side effects.
  
  
  OBJECTIVE
  The aim of this work was to evaluate the pharmacokinetic parameters of ciclopirox olamine after the buccal application of mucoadhesive film prepared by the solvent casting method.
  
  
  METHODS
  A chromatographic method using an internal standard was developed and validated for evaluation of ciclopirox olamine plasma concentrations. Method accuracy was 88.5-104.6% and 89.5-99.7% for interday and intraday assays, respectively.
  
  
  RESULTS
  The pharmacokinetic properties of ciclopirox olamine were studied in New Zealand White rabbits. The mucoadhesive films containing ciclopirox olamine in a total dose of 34.4 (33.0; 35.9) mg kg-1 were applied to all the rabbits. Plasma ciclopirox olamine concentrations were determined during the 12 h following application. The time taken to reach maximum plasma concentration was 1.7 (1.1; 2.2) h after the drug administration with cmax 5.73 (4.18; 7.28) μg mL-1. Overall elimination half-life was 3.8 (1.9; 10.8) h.
  
  
  CONCLUSIONS
  The experiment suggests that oral mucoadhesive film may be a valuable alternative ciclopirox olamine administration.
authors.forename: Ivana
authors.initials: I
authors.lastname: Lukášová
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42 Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Muselík
authors.forename: David
authors.initials: D
authors.lastname: Vetchý
authors.forename: Jan
authors.initials: J
authors.lastname: Gajdziok
authors.forename: Markéta
authors.initials: M
authors.lastname: Gajdošová
authors.forename: Jan
authors.initials: J
authors.lastname: Juřica
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Knotek
authors.forename: Karel
authors.initials: K
authors.lastname: Hauptman
authors.forename: Vladimír
authors.initials: V
authors.lastname: Jekl
mesh_terms: D000278:Administration, Buccal; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D000077768:Ciclopirox; D004305:Dose-Response Relationship, Drug; D008297:Male; D015394:Molecular Structure; D011728:Pyridones / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; D000077768:Ciclopirox
keywords: Buccal application; ciclopirox olamine; isocratic chromatographic method; mucoadhesive buccal films; pharmacokinetics; rabbits