title: Reductive Umpolung of Carbonyl Derivatives with Visible-Light Photoredox Catalysis: Direct Access to Vicinal Diamines and Amino Alcohols via α-Amino Radicals and Ketyl Radicals.
abstract: Visible-light-mediated photoredox-catalyzed aldimine-aniline and aldehyde-aniline couplings have been realized. The reductive single electron transfer (SET) umpolung of various carbonyl derivatives enabled the generation of intermediary ketyl and α-amino radical anions, which were utilized for the synthesis of unsymmetrically substituted 1,2-diamines and amino alcohols.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Fava
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Anthony
authors.initials: A
authors.lastname: Millet
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Masaki
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Loescher
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany. Magnus.Rueping@rwth-aachen.de.|King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC), Thuwal, 23955-6900, Saudi Arabia. Magnus.Rueping@rwth-aachen.de.
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
keywords: amino alcohols; diamines; photocatalysis; redox chemistry; umpolung