title: Fundamentals of Neurogastroenterology: Basic Science.
abstract: This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled ROME IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs and new areas for future research into their pathophysiology.
authors.affiliation: Gastrointestinal Diseases Research Unit, Kingston General Hospital, Kingston, Ontario, Canada. Electronic address: vanners@hdh.kari.net.
authors.forename: Stephen
authors.initials: S
authors.lastname: Vanner
authors.affiliation: Oklahoma Center for Neuroscience, Department of Physiology, VA Medical Center, University of Oklahoma, Health Sciences Center, Oklahoma City, Oklahoma.
authors.forename: Beverley
authors.initials: B
authors.lastname: Greenwood-Van Meerveld
authors.affiliation: Department of Neurological Sciences, Pharmacology and Medicine Division, Gastroenterology and Hepatology, University of Vermont, Burlington, Vermont.
authors.forename: Gary
authors.initials: G
authors.lastname: Mawe
authors.affiliation: Department of Medicine and Physiology, University of Maryland, School of Medicine, Baltimore, Maryland.
authors.forename: Terez
authors.initials: T
authors.lastname: Shea-Donohue
authors.affiliation: Farncombe Family Digestive Health Research Institute, McMaster University, Health Sciences Center, Hamilton, Ontario, Canada.
authors.forename: Elena F
authors.initials: EF
authors.lastname: Verdu
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio.
authors.forename: Jackie
authors.initials: J
authors.lastname: Wood
authors.affiliation: Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Grundy
keywords: enteric nervous system; mucosal barrier function; neuroimmune signaling; sensory physiology