title: Effects of Prunus mume Sieb. et Zucc. extract and its biopolymer encapsulation on a mouse model of colitis.
abstract: BACKGROUND
  Prunus mume suppresses various diseases caused by inflammation response and exhibits antioxidant and free radical-scavenging activities. Therefore this study determined the effect of an aqueous P. mume (PM) extract in a mouse colitis model and investigated the value of biopolymer encapsulation, facilitating targeted delivery to the colon. Colitis was induced by administration of 30 g kg-1dextran sulfate sodium to male BALB/c mice for 7 days prior to treatment with vehicle, 50 mg kg-1PM extract or biopolymer-encapsulated PM extract, or 50 mg kg-1sulfasalazine.
  
  
  RESULTS
  Histological examination of the colon in BALB/c mice showed epithelial destruction and mucosal infiltration of inflammatory cells. These changes were attenuated in PM-treated mice, which had lower levels of inflammatory cytokines, cyclooxygenase 2 and immunoglobulins (IgA, IgM and IgE) compared with the vehicle-treated colitis group. The PM extract showed concentration-dependent radical scavenging and superoxide dismutase-like antioxidant activities.
  
  
  CONCLUSIONS
  These results indicated that the effects of the PM extract on colitis were not influenced by biopolymer encapsulation and that this PM extract could be a potential therapeutic agent for inflammatory bowel disease. © 2016 Society of Chemical Industry.
authors.affiliation: Department of Animal Science and Technology, Chung-Ang University, 4726 Seodong-daero, Daedeok-myeon, Anseong-si, Gyeonggi, 456-756, Republic of Korea.
authors.forename: Seung Yun
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Animal Science and Technology, Chung-Ang University, 4726 Seodong-daero, Daedeok-myeon, Anseong-si, Gyeonggi, 456-756, Republic of Korea.
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Animal Science and Technology, Chung-Ang University, 4726 Seodong-daero, Daedeok-myeon, Anseong-si, Gyeonggi, 456-756, Republic of Korea.
authors.forename: Sun Jin
authors.initials: SJ
authors.lastname: Hur
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D001704:Biopolymers / Q000737:chemistry; D003106:Colon / Q000276:immunology / Q000473:pathology; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D005511:Food Handling; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D015212:Inflammatory Bowel Diseases / Q000178:diet therapy* / Q000276:immunology / Q000473:pathology; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D008297:Male; D008807:Mice, Inbred BALB C; D009929:Organ Size; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D027861:Prunus / Q000737:chemistry*; D011897:Random Allocation; D015430:Weight Gain
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001704:Biopolymers; D016166:Free Radical Scavengers; D005765:Gastrointestinal Agents; D010936:Plant Extracts; D016264:Dextran Sulfate
keywords: Prunus mume; anti-inflammatory; antioxidant; biopolymer encapsulation; inflammatory bowel disease