title: Whole-body MR neurography: Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease.
abstract: To evaluate the feasibility of whole-body magnetic resonance neurography (WBMRN) in polyneuropathy for technical feasibility, distribution of nerve abnormalities, and differentiation.
  
  
  
  Twenty WBMRN examinations were performed on a 3T scanner over 2 years. Patient demographics including history of hereditary and acquired neuropathy were recorded. The images were evaluated by two independent readers with nerve imaging experience for quality. The nerve signal and size alterations were measured in the brachial plexus, lumbosacral plexus, and femoral and sciatic nerves; diffusion tensor imaging parameters (fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) were determined in plexuses, and tractography was performed. Nonparametric Wilcoxon rank sum test, receiver operating characteristic (ROC) analysis, and intraclass correlation coefficients (ICCs) were obtained.
  
  
  
  Excellent image quality was obtained for the majority of lumbosacral (LS) plexus (18/20) and 50% of brachial plexus (10/20) regions. Qualitatively among cases, the nerve hyperintensity and/or thickening involved the brachial plexus (11/11), LS plexus (7/11), and both plexuses (7/11), with most nerve thickenings observed in Charcot-Marie-Tooth disease type 1. The nerve signal intensity alterations were significantly different for both brachial (P < 0.05) and LS (P < 0.05) plexuses in cases versus controls. The femoral and sciatic nerve size alterations were different (P < 0.05), while signal intensity differences were not significant (P = 0.1-0.97). Transverse dimensions of C8 (4 mm), L5 (6.2 mm) and S1 (5.1 mm) nerve roots, and sciatic nerves (10.2 mm) were the most accurate diagnostic performance measures in distinguishing cases from controls.
  
  
  
  WBMRN is feasible for use in the clinical practice for the identification and potential characterization of polyneuropathy. J. Magn. Reson. Imaging 2016;44:1513-1521.
authors.affiliation: Musculoskeletal Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.|Musculoskeletal Radiology, Russell H Morgan Department of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Avneesh
authors.initials: A
authors.lastname: Chhabra
authors.affiliation: Musculoskeletal Radiology, Hospital of Special Surgery, New York, New York, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Carrino
authors.affiliation: Musculoskeletal Radiology, Russell H Morgan Department of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Sahar J
authors.initials: SJ
authors.lastname: Farahani
authors.affiliation: Musculoskeletal Radiology, Russell H Morgan Department of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Gaurav K
authors.initials: GK
authors.lastname: Thawait
authors.affiliation: Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Charlotte J
authors.initials: CJ
authors.lastname: Sumner
authors.affiliation: Musculoskeletal Radiology, Russell H Morgan Department of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA.|Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Vibhor
authors.initials: V
authors.lastname: Wadhwa
authors.affiliation: Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Vinay
authors.initials: V
authors.lastname: Chaudhary
authors.affiliation: Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Lloyd
mesh_terms: D000328:Adult; D002607:Charcot-Marie-Tooth Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D011115:Polyneuropathies / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods*
keywords: Charcot-Marie-Tooth (CMT) disease; LS plexus; MR neurography; brachial plexus; whole body magnetic resonance imaging