title: Mediastinal irradiation in a patient affected by lung carcinoma after heart transplantation: Helical tomotherapy versus three dimensional conformal radiotherapy.
abstract: Patients who have undergone solid organ transplants are known to have an increased risk of neoplasia compared with the general population. We report our experience using mediastinal irradiation with helical tomotherapy versus three-dimensional conformal radiation therapy to treat a patient with lung carcinoma 15 years after heart transplantation. Our dosimetric evaluation showed no particular difference between the techniques, with the exception of some organs. Mediastinal irradiation after heart transplantation is feasible and should be considered after evaluation of the risk. Conformal radiotherapy or intensity-modulated radiotherapy appears to be the appropriate treatment in heart-transplanted oncologic patients.
authors.affiliation: European Medical Imaging - Radiation Oncology - Fondazione Muto-onlus, Napoli, Italia Casavatore, Naples Italy.
authors.forename: Francesca M
authors.initials: FM
authors.lastname: Giugliano
authors.affiliation: European Medical Imaging - Radiation Oncology - Fondazione Muto-onlus, Napoli, Italia Casavatore, Naples Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Iorio
authors.affiliation: UOC Radiation Oncology - Istituto Nazionale per lo studio e la cura dei tumori "Fondazione Giovanni Pascale" - IRCCS Naples Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Cammarota
authors.affiliation: European Medical Imaging - Radiation Oncology - Fondazione Muto-onlus, Napoli, Italia Casavatore, Naples Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Toledo
authors.affiliation: European Medical Imaging - Radiation Oncology - Fondazione Muto-onlus, Napoli, Italia Casavatore, Naples Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Senese
authors.affiliation: European Medical Imaging - Radiation Oncology - Fondazione Muto-onlus, Napoli, Italia Casavatore, Naples Italy.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Francomacaro
authors.affiliation: European Medical Imaging - Radiation Oncology - Fondazione Muto-onlus, Napoli, Italia Casavatore, Naples Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Muto
authors.affiliation: UOC Radiation Oncology - Istituto Nazionale per lo studio e la cura dei tumori "Fondazione Giovanni Pascale" - IRCCS Naples Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Muto
keywords: Heart transplantation; mediastinal irradiation; tomotherapy