title: Patients' knowledge and fear of colorectal cancer risk in inflammatory bowel disease.
abstract: OBJECTIVE
  To investigate knowledge and fear of colorectal cancer (CRC) risk in inflammatory bowel disease (IBD) patients.
  
  
  METHODS
  A 12-item self-administered questionnaire, developed after a careful literature review, was administered to all consecutive IBD patients treated with infliximab who were followed up at Nancy University Hospital (Vandoeuvre-lès-Nancy, France) between February and May 2012.
  
  
  RESULTS
  Altogether 100 patients including 72 with Crohn's disease (CD) were included. Only 7.0% of patients spontaneously mentioned CRC risk as a main feature of IBD and 37.0% as a potential IBD complication. CRC was the most feared complication by 26 patients [ulcerative colitis (UC) 46.4% vs CD 18.1%, P < 0.01]. Two-thirds of patients knew that IBD increases CRC risk (UC 81.9% vs CD 57.1%, P = 0.02). Their main source of information was their gastroenterologist (52.0%). On the best screening method for CRC, 86.0% of the respondents mentioned colonoscopy. Only 32.0% of patients knew that it has to be performed 10 years after diagnosis. In case of dysplasia, 51.0% of the patients would not undergo colectomy (CD 59.7% vs UC 28.6%, P < 0.01), mainly due to the fear of having ostomy bags. Only one-quarter of UC patients were aware of the chemopreventive effect of 5-aminosalicylates on CRC risk.
  
  
  CONCLUSIONS
  Two-thirds of IBD patients are aware of the risk of CRC. UC patients have a better knowledge of this risk and are more afraid of this complication. Our results underscore the need for therapeutic education about CRC in IBD patients.
authors.affiliation: Department of Hepato-Gastroenterology and Inserm U954, Nancy University Hospital, Lorraine University, Vandoeuvre-lès-Nancy, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Lopez
authors.affiliation: Department of Hepato-Gastroenterology and Inserm U954, Nancy University Hospital, Lorraine University, Vandoeuvre-lès-Nancy, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Collet-Fenetrier
authors.affiliation: Department of Hepato-Gastroenterology and Inserm U954, Nancy University Hospital, Lorraine University, Vandoeuvre-lès-Nancy, France.
authors.forename: Arthur
authors.initials: A
authors.lastname: Belle
authors.affiliation: Department of Hepato-Gastroenterology and Inserm U954, Nancy University Hospital, Lorraine University, Vandoeuvre-lès-Nancy, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D003082:Colectomy / Q000523:psychology; D003093:Colitis, Ulcerative / Q000150:complications / Q000523:psychology; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control / Q000523:psychology; D003424:Crohn Disease / Q000150:complications / Q000523:psychology; D055088:Early Detection of Cancer / Q000379:methods / Q000523:psychology; D005239:Fear; D005260:Female; D005602:France; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D010865:Pilot Projects; D018570:Risk Assessment; D011795:Surveys and Questionnaires
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016588:Anticarcinogenic Agents; D019804:Mesalamine
keywords: colorectal cancer, Crohn disease; fear; inflammatory bowel disease; knowledge; ulcerative colitis