title: Incidence, Characteristics, and Implications of Seizures in Patients With Glioblastoma.
abstract: BACKGROUND
  Seizures in patients with glioblastoma are associated with worse quality of life. However, their incidence, clinical characteristics, and prognostic implications are less well characterized.
  
  
  OBJECTIVE
  This study was undertaken to provide a contemporary experience along with benchmark data relevant to the above in patients with glioblastoma. It also sought to reexplore improved survival with seizures, as observed by others.
  
  
  METHODS
  In this single-institution study, patients with glioblastoma from 2010 through 2014 had their medical records reviewed in detail.
  
  
  RESULTS
  Among 122 patients, 58 (48%) had a seizure history. Of these, 67% had more than 1, 41% had generalized seizures, and most received antiseizure medication (most commonly levetiracetam). The median survival for patients with seizures was 1.66 years and 0.87 years for those without (hazard ratio for risk of death with seizures: 0.72; 95% confidence interval: 0.43, 1.21; P = .22 by the log-rank test).
  
  
  CONCLUSIONS
  Seizures are common in patients with glioblastoma and, in contrast to earlier reports, are not associated with a statistically significant improvement in survival.
authors.affiliation: 1 Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: John Y
authors.initials: JY
authors.lastname: Shin
authors.affiliation: 2 Department of Oncology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Sani H
authors.initials: SH
authors.lastname: Kizilbash
authors.affiliation: 2 Department of Oncology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Robinson
authors.affiliation: 3 Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Joon H
authors.initials: JH
authors.lastname: Uhm
authors.affiliation: 2 Department of Oncology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Aminah
authors.initials: A
authors.lastname: Jatoi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000150:complications* / Q000401:mortality; D005260:Female; D005909:Glioblastoma / Q000150:complications* / Q000401:mortality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D016019:Survival Analysis; D055815:Young Adult
keywords: glioblastoma; quality of life; seizures; survival