title: Rhodium(I)-Catalyzed Intermolecular Hydroacylation of α-Keto Amides and Isatins with Non-Chelating Aldehydes.
abstract: The application of the bidentate, electron-rich bisphosphine ligand, 1,3-bis(dicyclohexyl)phosphine-propane (dcpp), in rhodium(I)-catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α-keto amides are shown to undergo hydroacylation with a variety of non-chelating linear and branched aliphatic aldehydes. Also reported is the synthesis of new bidentate chiral phosphine ligands, and their application in hydroacylation is discussed.
authors.affiliation: University of California, Irvine, Department of Chemistry, Natural Sciences I, Irvine, California 92697, United States, ; University of Toronto, Department of Chemistry, 80 St. George St., Toronto, ON, Canada M5S 3H6.
authors.forename: Kevin G M
authors.initials: KG
authors.lastname: Kou
authors.affiliation: University of Toronto, Department of Chemistry, 80 St. George St., Toronto, ON, Canada M5S 3H6.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Longobardi
authors.affiliation: University of California, Irvine, Department of Chemistry, Natural Sciences I, Irvine, California 92697, United States.
authors.forename: Vy M
authors.initials: VM
authors.lastname: Dong
keywords: P ligands; asymmetric catalysis; hydroacylation; ketone; rhodium