title: [Analysis of Factors Influencing Peripheral Blood Stem Cell Collection of 151 Lymphoma Cases].
abstract: OBJECTIVE
  To analyze the influential factors related to mobilization and collection of stem cells so as to improve the collection efficiency of autologous peripheral stem cell transplantation in lymphoma patients.
  
  
  METHODS
  The peripheral blood stem cell collection data of 151 cases of lymphoma in our hospital was analyzed retrospectively. The relationship between the harvested CD34(+) stem cells and some factors, such as age, sex, height, weight, histological type, staging, mobilization programs, collecting days, blood transfusion, time and duration of chemotherapy, was analyzed.
  
  
  RESULTS
  The single factor analysis showed that sex, height, weight, histological type, staging, mobilization program, collecting days, blood transfusion were not significantly associated with CD34(+) stem cells collection, respectively. Age (r = -0.248, P = 0.002), duration of sick and cycles of chemotherapy were significantly associated with CD34(+) cell collection. At the age older than 50 years, the collected CD34(+) cell number decreased significantly; and at the age older than 60 years, the CD34(+) cell number was greatly reduced; CD34(+) cells non-significantly correlated with peripheral blood WBC (r = 0.053, P = 0.527), but significantly with the percentage of mononuclear cells (r = 0.260, P = 0.002) and the absolute value of mononuclear cells (r = 0.338, P = 0.00003) .
  
  
  CONCLUSIONS
  The patients less than 60 years old, fewer chemotherapy cycles, shorter duration time or PB mononuclear cells between (2-6) × 10(9)/L may contribute to the better mobilization and collection of peripheral blood stem cells.
authors.affiliation: Department of Blood Transfusion. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China. E-mail: sunweide_2010@sina.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Blood Transfusion. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Blood Transfusion. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xie
authors.affiliation: Department of Blood Transfusion. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Yang
authors.affiliation: Department of Blood Transfusion. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Xin-Yang
authors.initials: XY
authors.lastname: Hu
authors.affiliation: Department of Blood Transfusion. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Zhang
authors.affiliation: Department of Blood Transfusion. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Dai
mesh_terms: D000367:Age Factors; D018952:Antigens, CD34 / Q000378:metabolism; D001803:Blood Transfusion; D002452:Cell Count; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D012189:Retrospective Studies; D014182:Transplantation, Autologous
chemical_list: D018952:Antigens, CD34