title: [Value of plasma C-reactive protein and lactate dehydrogenase levels in the diagnosis of intestinal obstruction in an emergency department].
abstract: BACKGROUND
  Intestinal obstruction is one of the most frequent surgical emergencies. Its diagnosis is essentially based on clinical history, physical exploration and image tests. The aim of this study was to analyze the diagnostic value of acute phase reactants in patients with benign versus malign intestinal obstruction.
  
  
  METHODS
  Historical cohort study of 53 patients who underwent surgery because of intestinal obstruction and/or non-obstructive colorectal cancer. The patients were placed in three groups: group 1 (colorectal cancer with intestinal obstruction) (n=23), group 2 (benign intestinal obstruction)(n=10) and group 3 (non-obstructive cancer of the colon)(n=20). We determined the initial plasma values of the C-reactive protein (CRP) and the lactate dehydrogenase (LDH)enzyme.
  
  
  RESULTS
  CRP was quantitatively higher in patients with benign intestinal obstruction (group 2) (p=0.001), while LDH was quantitatively higher in group 1 (patients with obstructive cancer). The plasma levels of LDH were significantly greater in the groups with intestinal obstruction (groups 1 and 2) than in patients without obstruction (p<0.001). Plasma levels of CRP above 11 mg/l and of LDH above 317 U/L showed an acceptable diagnostic value for differentiating patients with intestinal obstruction, with areas under the ROC curve of 80% (CI 95% = 68-92%) and 86% (CI 95%= 75-96%)respectively. Their diagnostic value for differentiating benign or malign origin is lower, with areas under the ROC curve of 56% for levels of CRP > 24 ng/l (CI 95% = 30-82%) and 52% (CI 95% = 29-74%) for levels of LDH > 359 U/L.
  
  
  CONCLUSIONS
  Determination of plasma concentrations of CRP can help in the diagnosis of intestinal obstruction and indicate its benign or malign origin in emergency services.
authors.affiliation: Hospital Universitario Reina Sofía de Córdoba. rafa-calvo@hotmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Calvo-Rodríguez
authors.forename: F J
authors.initials: FJ
authors.lastname: Montero-Pérez
authors.forename: A
authors.initials: A
authors.lastname: García-Olid
authors.forename: E
authors.initials: E
authors.lastname: Baena-Delgado
authors.forename: J M
authors.initials: JM
authors.lastname: Gallardo-Valverde
authors.forename: J M
authors.initials: JM
authors.lastname: Calderón de la Barca-Gázquez
authors.forename: L M
authors.initials: LM
authors.lastname: Jiménez-Murillo
mesh_terms: D002097:C-Reactive Protein; D015331:Cohort Studies; D004636:Emergency Service, Hospital; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis*; D007770:L-Lactate Dehydrogenase
chemical_list: D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase