title: Advances in understanding - genetic basis of intellectual disability.
abstract: Intellectual disability is the most common developmental disorder characterized by a congenital limitation in intellectual functioning and adaptive behavior. It often co-occurs with other mental conditions like attention deficit/hyperactivity disorder and autism spectrum disorder, and can be part of a malformation syndrome that affects other organs. Considering the heterogeneity of its causes (environmental and genetic), its frequency worldwide varies greatly. This review focuses on known genes underlying (syndromic and non-syndromic) intellectual disability, it provides a succinct analysis of their Gene Ontology, and it suggests the use of transcriptional profiling for the prioritization of candidate genes.
authors.affiliation: Institute of Genomic Medicine, Catholic University School of Medicine, Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Chiurazzi
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: Filomena
authors.initials: F
authors.lastname: Pirozzi