title: Design of Fucoidan Functionalized - Iron Oxide Nanoparticles for Biomedical Applications.
abstract: This research aims to develop an iron oxide nanoparticle drug delivery system utilizing a recent material discovered from ocean, fucoidan. The material has drawn much interest due to many biomedical functions that have been proven for human health. One interesting point herein is that fucoidan is not only a sulfated polysaccharide, a polymer for stabilization of iron oxide nanoparticles, but plays a role of an anticancer agent also. Various approaches were investigated to optimize the high loading efficiency and explain the mechanism of nanoparticle formations. Fucoidan was functionalized on iron oxide nanoparticles by a direct coating or via amine groups. Also, a hydrophobic part of oleic acid was conjugated to the amine groups for a more favorable loading of poorly water-soluble anticancer drugs. This study proposed a novel system and an efficient method to functionalize fucoidan on iron oxide nanoparticle systems which will lead to a facilitation of a double strength treatment of cancer.
authors.forename: Khanh Nghia
authors.initials: KN
authors.lastname: Tran
authors.forename: Phuong Ha-Lien
authors.initials: PH
authors.lastname: Tran
authors.forename: Toi Van
authors.initials: TV
authors.lastname: Vo
authors.affiliation: Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University - Ho Chi Minh City, Vietnam. ttdthao@hcmiu.edu.vn.
authors.forename: Thao Truong-Dinh
authors.initials: TT
authors.lastname: Tran
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004337:Drug Carriers; D004339:Drug Compounding; D005296:Ferrous Compounds / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D053768:Metal Nanoparticles; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine; D019301:Oleic Acid / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005296:Ferrous Compounds; D011134:Polysaccharides; D019301:Oleic Acid; C007789:fucoidan; C034236:ferrous oxide