title: Replication protein A and more: single-stranded DNA-binding proteins in eukaryotic cells.
abstract: Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication, recombinational repair, and maintenance of genome stability. In human, the major SSB, replication protein A (RPA), is a stable heterotrimer composed of subunits of RPA1, RPA2, and RPA3, each of which is conserved not only in mammals but also in all other eukaryotic species. In addition to RPA, other SSBs have also been identified in the human genome, including sensor of single-stranded DNA complexes 1 and 2 (SOSS1/2). In this review, we summarize our current understanding of how these SSBs contribute to the maintenance of genome stability.
authors.affiliation: Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China liuting518@zju.edu.cn jhuang@zju.edu.cn.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.affiliation: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China liuting518@zju.edu.cn jhuang@zju.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
mesh_terms: D000818:Animals; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005057:Eukaryotic Cells; D042822:Genomic Instability; D006801:Humans; D051716:Replication Protein A / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D051716:Replication Protein A
keywords: genome instability; replication protein A; sensor of single-stranded DNA complex; single-stranded DNA-binding proteins