title: Adenocarcinoma of the Oesophagus and Oesophagogastric Junction: Analysis of Incidence and Risk Factors.
abstract: OBJECTIVE
  Conflicting data exist on the changes in the incidence of oesophageal (EAC) and oesophagogastric junction adenocarcinoma (EGJAC). In addition, risk factors of the disease are only partly known. The aim of the study was to evaluate the incidence of EAC and EGJAC in Finland as well as risk factors of these cancers.
  
  
  METHODS
  The complete number of new EAC and EGJAC cases between January 1980 and December 2007 in Finland was provided by the Finnish Cancer Registry. All treated EAC and EGJAC patients in the Pirkanmaa Hospital District between January 1980 and December 2007 were included in the study.
  
  
  RESULTS
  The incidence of EAC increased significantly in Finland. Barrett's oesophagus (BE) was associated with the risk of EAC and cholecystectomy with the risk of EGJAC.
  
  
  CONCLUSIONS
  A significant increase in EAC was found in Finland over the course of nearly 30 years, indicating that the increase in EAC in Finland is existent in the long term. BE was associated with the risk of EAC and cholecystectomy with the risk of EGJAC.
authors.affiliation: Departments of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland Department of Surgery, Kuopio University Hospital, Kuopio, Finland Tuomo.rantanen@kuh.fi.
authors.forename: Tuomo
authors.initials: T
authors.lastname: Rantanen
authors.affiliation: Department of Surgery, Division of Vascular Surgery, Tampere University Hospital and School of Medicine, Surgery, University of Tampere, Tampere, Finland.
authors.forename: Niku
authors.initials: N
authors.lastname: Oksala
authors.affiliation: Departments of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
authors.forename: Juhani
authors.initials: J
authors.lastname: Sand
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D001471:Barrett Esophagus / Q000453:epidemiology; D002763:Cholecystectomy / Q000706:statistics & numerical data; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D018662:Fundoplication / Q000706:statistics & numerical data; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D011230:Precancerous Conditions / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D055815:Young Adult
keywords: Finland; Oesophageal adenocarcinoma; epidemiology; incidence; oesophagogastric junction adenocarcinoma; risk factors