title: Wasabi leaf extracts attenuate adipocyte hypertrophy through PPARγ and AMPK.
abstract: Hypertrophy of adipocytes in obese adipose tissues causes metabolic abnormality by adipocytokine dysregulation, which promotes type 2 diabetes mellitus, hypertension, and dyslipidemia. We investigated the effects of wasabi (Wasabia japonica Matsum) leaf extracts on metabolic abnormalities in SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP/ZF), which are a model of metabolic syndrome. Male SHRSP/ZF rats aged 7 weeks were divided into two groups: control and wasabi leaf extract (WLE) groups, which received water or oral treatment with 4 g/kg/day WLE for 6 weeks. WLE improved the body weight gain and high blood pressure in SHRSP/ZF rats, and the plasma triglyceride levels were significantly lower in the WLE group. Adipocyte hypertrophy was markedly prevented in adipose tissue. The expression of PPARγ and subsequent downstream genes was suppressed in the WLE group adipose tissues. Our data suggest that WLE inhibits adipose hypertrophy by suppressing PPARγ expression in adipose tissue and stimulating the AMPK activity by increased adiponectin.
authors.affiliation: a Shimane Institute for Industrial Technology , Matsue , Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Oowatari
authors.affiliation: a Shimane Institute for Industrial Technology , Matsue , Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: a Shimane Institute for Industrial Technology , Matsue , Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Katsube
authors.affiliation: b Grandhill Osaka Co. Ltd. , Osaka , Japan.
authors.forename: Kiyohisa
authors.initials: K
authors.lastname: Iinuma
authors.affiliation: c School of Pharmaceutical Sciences , Mukogawa Women's University , Nishinomiya , Japan.
authors.forename: Hisae
authors.initials: H
authors.lastname: Yoshitomi
authors.affiliation: c School of Pharmaceutical Sciences , Mukogawa Women's University , Nishinomiya , Japan.
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D052242:Adiponectin / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D047495:PPAR gamma / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D055647:Rats, Transgenic; D015398:Signal Transduction; D014280:Triglycerides / Q000097:blood; D031228:Wasabia / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D052242:Adiponectin; D047495:PPAR gamma; D010936:Plant Extracts; D014280:Triglycerides; D055372:AMP-Activated Protein Kinases
keywords: AMPK; PPARγ; SHRSP.Z-Leprfa/IzmDmcr rat; adipocyte hypertrophy; wasabi leaf extract