title: Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia.
abstract: This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.
authors.affiliation: Department of Veteran Affairs VISN-22 Mental Illness Research Education Clinical Center, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA. Electronic address: wdunn@mednet.ucla.edu.
authors.forename: Walter
authors.initials: W
authors.lastname: Dunn
authors.affiliation: Department of Psychology and Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel; Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Rassovsky
authors.affiliation: Department of Veteran Affairs VISN-22 Mental Illness Research Education Clinical Center, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Wynn
authors.affiliation: Department of Neurology, University of California, Los Angeles, USA.
authors.forename: Allan D
authors.initials: AD
authors.lastname: Wu
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA; Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Iacoboni
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hellemann
authors.affiliation: Department of Veteran Affairs VISN-22 Mental Illness Research Education Clinical Center, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Green
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000503:physiopathology* / Q000628:therapy; D065908:Transcranial Direct Current Stimulation / Q000379:methods
keywords: Cognition; Mismatch negativity; Schizophrenia; Target engagement; Transcranial direct current stimulation; tDCS