title: Low level of Nesfatin-1 is associated with gestational diabetes mellitus.
abstract: BACKGROUND
  Gestational diabetes mellitus (GDM) occurs in ∼10-25% of pregnancies. Nesfatin-1, plays a role in carbohydrate metabolism by inhibiting glucagon secretion, besides has a glucose-dependent insulinotropic effect. Explanation of the GDM pathogenesis is important due to preventing gestational complications. We aimed to investigate relationship between GDM and Nesfatin-1.
  
  
  METHODS
  Seventy-nine pregnant subjects were randomly allocated to either GDM group (GDG, n = 38) or control group (CG, n = 41). For GDM diagnosis, 50 and 100 g oral glucose tolerance test (OGTT) were used. Nesfatin-1, insulin and other parameters were measured for all subjects. The homeostasis model assessment-insulin resistance (HOMA-IR) was calculated.
  
  
  RESULTS
  Nesfatin-1 was found lower and insulin was found higher in GDG than CG. Negative correlation has been founded between Nesfatin-1 with weight, BMI, fasting glucose, serum glucose level at first hour of the 50 g OGTT and HOMA-IR.
  
  
  CONCLUSIONS
  In this study, patients with GDM had lower Nesfatin-1 levels than without GDM. Therefore, when the Nesfatin-1 effects on the GDM pathogenesis is clear, it may be contributed to diagnosis and treatment of the GDM.
authors.affiliation: a Department of Endocrinology.
authors.forename: Ferit Kerim
authors.initials: FK
authors.lastname: Kucukler
authors.affiliation: b Department of Obstetrics and Gynecology , Faculty of Medicine, Hitit University , Corum , Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Gorkem
authors.affiliation: c Department of Endocrinology , Kayseri Training and Research Hospital , Kayseri , Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Simsek
authors.affiliation: d Department of Biochemistry , Faculty of Medicine, Hitit University , Corum , Turkey , and.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kocabas
authors.affiliation: e Department of Physiology , Faculty of Medicine, Ufuk University , Ankara , Turkey.
authors.forename: Sebnem
authors.initials: S
authors.lastname: Gulen
authors.affiliation: a Department of Endocrinology.
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
mesh_terms: D000328:Adult; D002135:Calcium-Binding Proteins / Q000097:blood*; D004268:DNA-Binding Proteins / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D011247:Pregnancy; D011897:Random Allocation
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: Gestational diabetes mellitus; Nesfatin-1; insulin resistance