title: [Treatment conditioning variables in elderly patients with acute myeloid leukemia. An institutional experience].
abstract: Patients over 60 years old with acute myeloid leukemia (AML) have a worse prognosis due to several factors that determine the therapeutic outcome. The main predictors of mortality in patients with AML reported in the literature were analyzed in our population. The primary objective was to analyze overall survival. The secondary objective was to determine treatment-related mortality, defined as death within eight weeks of starting treatment. It was designed as a retrospective study. A total of 133 treatment naive patients were included, from January 1991 to August 2014. The adjusted analysis showed that the most important variables to determine overall survival were the WBC count = 30 000 at diagnosis [adjusted HR 2.19 (1.06-4.53), p = 0.03)] and the Performance Status (ECOG) 3 or 4 [aHR 4.63 (1.69-12.68), p < 0.001)]. Performance Status 3-4 was the only variable that conditioned treatment related mortality, showing in the univariate analysis an OR 5.44 (CI 1.93-15.28, p < 0.001). It was also the only variable that kept its statistical power in the multivariate analysis adjusted OR (aOR) 12.40 (IC 1.12-137.17, p = 0.04). The inherent poor outcome in elderly patients diagnosed with AML is not fully understood. The best way of assessing these elderly patients should probably include not only age but the best way of assessing these elderly patients should probably include not only age but laboratory, genetic and molecular studies. Especially designed comorbidity and fragility indices should be included, along with functional status. Leukocytosis and poor quality of life were identified as the most powerfull factors for predicting mortality in our study.
authors.affiliation: Sección Hematología, Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Argentina. E-mail: alberto.gimenez@hospitalitaliano.org.ar.
authors.forename: Alberto D
authors.initials: AD
authors.lastname: Giménez Conca
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Arbelbide
authors.forename: Natalia
authors.initials: N
authors.lastname: Schutz
authors.forename: Victoria
authors.initials: V
authors.lastname: Otero
authors.forename: Dorotea
authors.initials: D
authors.lastname: Fantl
authors.forename: Bruno
authors.initials: B
authors.lastname: Ferreyro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality*; D007964:Leukocytosis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009026:Mortality; D016017:Odds Ratio; D011788:Quality of Life; D012044:Regression Analysis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: acute; elderly; leukemia; leukocytosis; performance status