title: Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A.
abstract: Deubiquitination via deubiquitinating enzymes (DUBs) has been emerged as one of the important post-translational modifications, resulting in the regulation of numerous target proteins. In this study, we screened new protein biomarkers for adipogenesis, and related studies showed that ubiquitin specific protease 19 (USP19) as a DUB is gradually decreased during adipogenesis and it regulates coronin 2A (CORO2A) as one of the components for the nuclear receptor co-repressor (NCoR) complex in some studies. The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis.
authors.affiliation: Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Key-Hwan
authors.initials: KH
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, College of Medicine, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Hyeon-Ju
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Jang-Joon
authors.initials: JJ
authors.lastname: Park
authors.affiliation: Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Eung-Ji
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, College of Medicine, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.|Department of Internal Medicine, CHA University, CHA General Hospital, Nonhyon-ro, Grangnam-Gu, Seoul 135-081, Republic of Korea.
authors.forename: Young-Kil
authors.initials: YK
authors.lastname: Choi
authors.affiliation: Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.|Department of Internal Medicine, College of Medicine, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea.
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Baek
mesh_terms: D050156:Adipogenesis / Q000235:genetics* / Q000502:physiology; D000818:Animals; D045744:Cell Line, Tumor; D000072017:Deubiquitinating Enzymes / Q000235:genetics* / Q000378:metabolism; D010450:Endopeptidases / Q000235:genetics*; D057809:HEK293 Cells; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics*; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics; D018168:Receptors, Retinoic Acid / Q000037:antagonists & inhibitors / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D008840:Microfilament Proteins; D034741:RNA, Small Interfering; D018168:Receptors, Retinoic Acid; C072061:coronin proteins; D010450:Endopeptidases; C559917:USP19 protein, human; D000072017:Deubiquitinating Enzymes
keywords: CORO2A; USP19; adipogenesis; deubiquitinating enzyme