title: Pathogenicity comparison between highly pathogenic and NADC30-like porcine reproductive and respiratory syndrome virus.
abstract: The pathogenicity of HNjz15, an NADC30-like strain of porcine reproductive and respiratory syndrome virus (PRRSV), was investigated and compared to that of a highly pathogenic PRRSV JAX1 strain. Six-week-old pigs infected with each virus showed typical clinical symptoms, including high fever and respiratory disorders. Pigs infected with JXA1 had more-severe clinical manifestations than pigs infected with HNjz15. HNjz15 replicated in vivo with kinetics similar to those of JXA1 but induced a lower level of PRRSV-specific antibody at the beginning of virus infection. Histopathologically, JXA1 infection led to more-severe lung lesions and broader organ tropism than HNjz15 did. Different from what was observed with the previously reported NADC30-like PRRSV JL580 strain, all HNjz15-infected pigs survived until the end of the study. All of these results indicated that NADC30-like PRRSV HNjz15 is virulent to pigs but is less pathogenic than the JXA1 and JL580 PRRSV strains.
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Sun
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Bai
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Guobiao
authors.initials: G
authors.lastname: Ji
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: He
authors.initials: H
authors.lastname: Yan
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Li
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Wang
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Tan
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China. xiaonanzhong@163.com.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, People's Republic of China. tiankg@263.net.|National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech District, 471003, Beijing, People's Republic of China. tiankg@263.net.|OIE Porcine Reproductive and Respiratory Syndrome Reference Laboratory, Beijing, People's Republic of China. tiankg@263.net.
authors.forename: Kegong
authors.initials: K
authors.lastname: Tian
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D008168:Lung / Q000473:pathology / Q000821:virology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000097:blood / Q000473:pathology / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000145:classification / Q000472:pathogenicity* / Q000502:physiology; D013552:Swine; D014774:Virulence
chemical_list: D000914:Antibodies, Viral
keywords: HNjz15; JXA1; NADC30-like; PRRSV; Pathogenicity