title: Maternal high-fat diet promotes onset of diabetes in rat offspring.
abstract: The onset and progression of type II diabetes is closely related to environmental factors, in particular dietary habit. Moreover, the environmental exposures very early in life can influence the risk for development of type II diabetes later in life. In this study, we investigated pathophysiological changes in the pups of maternal Spontaneously Diabetic Torii (SDT) rats that were fed a high-fat diet (HFD) throughout gestation and lactation. Maternal SDT rats were continued on HFD for 5 weeks, from day 8 of gestation to day 21 after birth, and biological analyses of the pups were performed from 2 to 22 weeks of age. Results of serum lipid levels in pups from dams fed HFD were higher than pups from dams fed a standard diet, and the onset of diabetes was significantly accelerated in pups from dams fed HFD. In pathological analyses, pups from dams fed HFD showed increases in liver weight and vacuolation of hepatic cells at 2 weeks of age. In conclusion, the metabolic disorder of lipids and glucose in SDT rats is closely related to the nutritional condition of dams during the periods of gestation and lactation.
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan.|Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Toriniwa
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Ryumon
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Inaba
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Hirao
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Yamanaka
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Maeno
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Wakako
authors.initials: W
authors.lastname: Sakakibara
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Morio
authors.initials: M
authors.lastname: Sumikawa
authors.affiliation: JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Chiba
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakamura
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Miyajima
authors.affiliation: Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia.
authors.forename: Fatchiyah
authors.initials: F
authors.lastname: Fatchiyah
authors.affiliation: Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Niigata, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000824:Animal Nutritional Physiological Phenomena / Q000502:physiology; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D059305:Diet, High-Fat / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D022781:Hepatocytes / Q000166:cytology; D007774:Lactation / Q000502:physiology; D050356:Lipid Metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D008431:Maternal-Fetal Exchange; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D014617:Vacuoles / Q000473:pathology
keywords: SDT rat; diabetic model; high-fat diet