title: Effects of Exercise Interventions and Physical Activity Behavior on Cancer Related Cognitive Impairments: A Systematic Review.
abstract: This systematic review analyzes current data on effects of exercise interventions and physical activity behavior on objective and subjective cancer related cognitive impairments (CRCI). Out of the 19 studies which met all inclusion criteria, five RCTs investigated rodents, whereas the other 14 trials explored humans and these included six RCTs, one controlled trial, two prospective noncontrolled trials, one case series, one observational study, and three cross-sectional studies. The results from animal models revealed positive effects of exercise during and after chemotherapy or radiation on structural alterations of the central nervous system, physiological as well as neuropsychological outcomes. The overall study quality in patient studies was poor. The current data on intervention studies showed preliminary positive effects of Asian-influenced movement programs (e.g., Yoga) with benefits on self-perceived cognitive functions as well as a reduction of chronic inflammation for breast cancer patients in the aftercare. Exercise potentially contributes to the prevention and rehabilitation of CRCI. Additional RCTs with standardized neuropsychological assessments and controlling for potential confounders are needed to confirm and expand preliminary findings.
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Zimmer
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
authors.forename: Freerk T
authors.initials: FT
authors.lastname: Baumann
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
authors.forename: Max
authors.initials: M
authors.lastname: Oberste
authors.affiliation: Chair of Sports Medicine, Chemnitz University of Technology, Thüringer Weg 11, 09126 Chemnitz, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Wright
authors.affiliation: German Center of Neurodegenerative Diseases, Arnoldstraße 18, 01307 Dresden, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Garthe
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schenk
authors.affiliation: Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Elter
authors.affiliation: Edith Cowan University Health and Wellness Institute, Joondalup, WA 6027, Australia.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Galvao
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Bloch
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
authors.forename: Sven T
authors.initials: ST
authors.lastname: Hübner
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Wolf
mesh_terms: D000818:Animals; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D064887:Observational Studies as Topic; D011446:Prospective Studies