title: Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge.
abstract: Modified vaccinia Ankara virus (MVA) is a smallpox vaccine candidate. This study was performed to determine if MVA vaccination provides long-term protection against rabbitpox virus (RPXV) challenge, an animal model of smallpox. Two doses of MVA provided 100% protection against a lethal intranasal RPXV challenge administered 9 months after vaccination.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Dorothy I
authors.initials: DI
authors.lastname: Jones
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Charles E
authors.initials: CE
authors.lastname: McGee
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Sample
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Sempowski
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Pickup
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA herman.staats@duke.edu.
authors.forename: Herman F
authors.identifier: 0000-0003-1039-1087
authors.initials: HF
authors.lastname: Staats
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007115:Immunization Schedule; D011817:Rabbits; D012899:Smallpox / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D016019:Survival Analysis; D014616:Vaccinia virus / Q000276:immunology*
chemical_list: D012900:Smallpox Vaccine