title: Metal-Organic-Framework-Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small-Molecule-Polymer Conjugates.
abstract: Herein, we report a strategy for exploiting nanoscale metal-organic frameworks (nano-MOFs) as templates for the layer-by-layer (LbL) assembly of polyelectrolytes. Because small-molecule drugs or imaging agents cannot be efficiently encapsulated by polyelectrolyte nanocapsules, we investigated two promising and biocompatible polymers (comb-shaped polyethylene glycol (PEG) and hyperbranched polyglycerol-based PEG) for the conjugation of model drugs and imaging agents, which were then encapsulated inside the nano-MOF-templated nanocapsules. Furthermore, we also systemically explored the release kinetics of the encapsulated conjugates, and examined how the encapsulation and/or release processes could be controlled by varying the composition and architecture of the polymers. We envision that our nano-MOFs-templated nanocapsules, through combining with small-molecule-polymer conjugates, will represent a new type of delivery system that could open up new opportunities for biomedical applications.
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Liu
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Chen
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Xiaojia
authors.initials: X
authors.lastname: Bao
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Yunyang
authors.initials: Y
authors.lastname: Ling
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Li
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China. chlwu@xmu.edu.cn.
authors.forename: Chuanliu
authors.initials: C
authors.lastname: Wu
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China. ybzhao@xmu.edu.cn.
authors.forename: Yibing
authors.initials: Y
authors.lastname: Zhao
keywords: drug delivery; layer-by-layer assembly; metal-organic frameworks; nanocapsules; polymers