title: Estimation of optical properties of neuroendocrine pancreas tumor with double-integrating-sphere system and inverse Monte Carlo model.
abstract: The investigation of laser-tissue interaction is crucial for diagnostics and therapeutics. In particular, the estimation of tissue optical properties allows developing predictive models for defining organ-specific treatment planning tool. With regard to laser ablation (LA), optical properties are among the main responsible for the therapy efficacy, as they globally affect the heating process of the tissue, due to its capability to absorb and scatter laser energy. The recent introduction of LA for pancreatic tumor treatment in clinical studies has fostered the need to assess the laser-pancreas interaction and hence to find its optical properties in the wavelength of interest. This work aims at estimating optical properties (i.e., absorption, μ a , scattering, μ s , anisotropy, g, coefficients) of neuroendocrine pancreas tumor at 1064 nm. Experiments were performed using two popular sample storage methods; the optical properties of frozen and paraffin-embedded neuroendocrine tumor of the pancreas are estimated by employing a double-integrating-sphere system and inverse Monte Carlo algorithm. Results show that paraffin-embedded tissue is characterized by absorption and scattering coefficients significantly higher than frozen samples (μ a of 56 cm(-1) vs 0.9 cm(-1), μ s of 539 cm(-1) vs 130 cm(-1), respectively). Simulations show that such different optical features strongly influence the pancreas temperature distribution during LA. This result may affect the prediction of therapeutic outcome. Therefore, the choice of the appropriate preparation technique of samples for optical property estimation is crucial for the performances of the mathematical models which predict LA thermal outcome on the tissue and lead the selection of optimal LA settings.
authors.affiliation: IHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France. paola.saccomandi@ihu-strasbourg.eu.
authors.forename: Paola
authors.initials: P
authors.lastname: Saccomandi
authors.affiliation: Unit of Measurements and Biomedical Instrumentation, Departmental Faculty of Engineering, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
authors.forename: Enza Stefania
authors.initials: ES
authors.lastname: Larocca
authors.affiliation: Unit of Measurements and Biomedical Instrumentation, Departmental Faculty of Engineering, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
authors.forename: Veneranda
authors.initials: V
authors.lastname: Rendina
authors.affiliation: Unit of Measurements and Biomedical Instrumentation, Departmental Faculty of Engineering, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Schena
authors.affiliation: ICTEAM-Machine Learning Group, Université catholique de Louvain, Place Sainte Barbe 2, 1348, Louvain-la-Neuve, Belgium.
authors.forename: Roberto
authors.initials: R
authors.lastname: D'Ambrosio
authors.affiliation: Unit of Anatomical Pathology, Departmental Faculty of Medicine, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Crescenzi
authors.affiliation: Unit of Digestive Endoscopy, Departmental Faculty of Medicine, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
authors.forename: Francesco Maria
authors.initials: FM
authors.lastname: Di Matteo
authors.affiliation: Unit of Measurements and Biomedical Instrumentation, Departmental Faculty of Engineering, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Silvestri
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D008954:Models, Biological; D008962:Models, Theoretical; D009010:Monte Carlo Method; D055620:Optical Phenomena; D010190:Pancreatic Neoplasms / Q000601:surgery*; D013696:Temperature
keywords: Bioheat equation; Human pancreas; Inverse Monte Carlo; Laser-tissue interaction; Neuroendocrine pancreas tumor; Optical properties