title: Atypical depressive symptoms as a predictor of treatment response to exercise in Major Depressive Disorder.
abstract: Effective treatment of Major Depressive Disorder (MDD) will require the development of alternative treatments and the ability for clinicians to match patients with the treatment likely to produce the greatest effect. We examined atypical depression subtype as a predictor of treatment response to aerobic exercise augmentation in persons with non-remitted MDD. Our results revealed a small-to-moderate effect, particularly in a group assigned to high-dose exercise (semi-partial eta-squared =0.0335, p=0.0735), indicating that those with atypical depression tended to have larger treatment response to exercise. Through this hypothesis-generating analysis, we indicate the need for research to examine depression subtype, along with other demographic, clinical and biological factors as predictors of treatment response to exercise.
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-09119, United States. Electronic address: chad.rethorst@utsouthwestern.edu.
authors.forename: Chad D
authors.initials: CD
authors.lastname: Rethorst
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-09119, United States.
authors.forename: Jian
authors.initials: J
authors.lastname: Tu
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-09119, United States.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Carmody
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-09119, United States.
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Greer
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-09119, United States.
authors.forename: Madhukar H
authors.initials: MH
authors.lastname: Trivedi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003863:Depression / Q000523:psychology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063189:Symptom Assessment; D016896:Treatment Outcome; D055815:Young Adult