title: Copper-Catalyzed O-Difluoromethylation of Functionalized Aliphatic Alcohols: Access to Complex Organic Molecules with an OCF2H Group.
abstract: A two-step synthetic strategy toward difluoromethyl ethers via a CuI-catalyzed reaction of the alcohols, bearing additional protected functionalities, with FSO2CF2CO2H has been developed. The high potential of the developed protocol has been shown by preparing novel OCF2H-analogues of GABA and l-proline. The described transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage preparation of complex OCF2H-containing organic compounds as well as building blocks for drug discovery.
authors.affiliation: Enamine, Ltd., 78 Chervonotkatska str., 02094 Kyiv, Ukraine.
authors.forename: Kostiantyn
authors.initials: K
authors.lastname: Levchenko
authors.affiliation: Enamine, Ltd., 78 Chervonotkatska str., 02094 Kyiv, Ukraine.
authors.forename: Olexandr P
authors.initials: OP
authors.lastname: Datsenko
authors.affiliation: Department of Organic Chemistry, Kiev Polytechnic Institute , Pr. Pobedy 37, 03056 Kiev, Ukraine.
authors.forename: Oleh
authors.initials: O
authors.lastname: Serhiichuk
authors.affiliation: Enamine, Ltd., 78 Chervonotkatska str., 02094 Kyiv, Ukraine.
authors.forename: Andrei
authors.initials: A
authors.lastname: Tolmachev
authors.affiliation: Homogeneous Catalysis and Molecular Design Research Group at Center of Molecular and Macromolecular Studies, Polish Academy of Sciences , Sienkiewicza 112, PL-90-363 Łódź, Poland.
authors.forename: Viktor O
authors.initials: VO
authors.lastname: Iaroshenko
authors.affiliation: Enamine, Ltd., 78 Chervonotkatska str., 02094 Kyiv, Ukraine.|Department of Chemistry, Taras Shevchenko National University of Kyiv , Volodymyrska Street, 64, Kyiv 01601, Ukraine.
authors.forename: Pavel K
authors.initials: PK
authors.lastname: Mykhailiuk