title: Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus.
abstract: Salidroside is a functionally versatile natural compound from the perennial flowering plant Rhodiola rosea L. Here, we examined obese mice treated with salidroside at the dosage of 50 mg/kg/day for 48 days. Mice treated with salidroside showed slightly decreased food intake, body weight and hepatic triglyceride content. Importantly, salidroside treatment significantly improved glucose and insulin tolerance. It also increased insulin singling in both liver and epididymal white adipose tissue (eWAT). In addition, salidroside markedly ameliorated hyperglycemia in treated mice, which is likely due to the suppression of gluconeogenesis by salidroside as the protein levels of a gluconeogenic enzyme G6Pase and a co-activator PGC-1α were all markedly decreased. Further analysis revealed that adipogenesis in eWAT was significantly decreased in salidroside treated mice. The infiltration of macrophages in eWAT and the productions of pro-inflammatory cytokines were also markedly suppressed by salidroside. Furthermore, the leptin signal transduction in hypothalamus was improved by salidroside. Taken together, these euglycemic effects of salidroside may due to repression of adipogenesis and inflammation in eWAT and stimulation of leptin signal transduction in hypothalamus. Thus, salidroside might be used as an effective anti-diabetic agent.
authors.affiliation: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Meihong
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Geratology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, PRC.
authors.forename: Lan
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, PRC.
authors.forename: Lili
authors.initials: L
authors.lastname: Yao
authors.affiliation: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Caiping
authors.initials: C
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Ketao
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Medicine, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Muchen
authors.initials: M
authors.lastname: Xu
authors.affiliation: School of Medicine, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Ningmei
authors.initials: N
authors.lastname: Shen
authors.affiliation: Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M University Health Science Center, USA.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Guo
authors.affiliation: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Cheng
authors.initials: C
authors.lastname: Sun
authors.affiliation: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PRC.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Yang
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004822:Epididymis; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005960:Glucosides / Q000008:administration & dosage* / Q000494:pharmacology; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D020738:Leptin / Q000378:metabolism*; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000378:metabolism; D010636:Phenols / Q000008:administration & dosage* / Q000494:pharmacology; D014280:Triglycerides / Q000737:chemistry
chemical_list: D005960:Glucosides; D020738:Leptin; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010636:Phenols; C485290:Ppargc1a protein, mouse; D014280:Triglycerides; D005952:Glucose-6-Phosphatase; C009172:rhodioloside