title: Is solvent/detergent plasma better than standard fresh-frozen plasma? A systematic review and an expert consensus document.
abstract: Only a few studies have compared solvent/detergent plasma (SD-plasma) to standard fresh-frozen plasma (FFP) in terms of efficacy and safety.
  
  
  
  A systematic review was performed in order to develop a consensus document on the use of SD-plasma. Moreover, a pharmacoeconomic study was performed in order to assess whether the use of SD-plasma can be cost-effective with respect to the use of FFP. A multidisciplinary panel used the systematic review and the GRADE methodology to develop evidence-based recommendations on this topic.
  
  
  
  Based on moderate to very low quality evidence, the panel developed the following consensus statements: (i) the panel suggested that SD-plasma is safer than FFP; (ii) the panel could not express for or against a greater efficacy of SD-plasma as compared to FFP; (iii) the panel suggested that in patients undergoing liver transplantation SD-plasma can be preferred over FFP; (iv) the panel suggested that SD-plasma can be preferred over FFP in patients with thrombotic thrombocytopenic purpura undergoing plasma-exchange procedures; (v) the panel could not recommend for or against preferring SD-plasma over FFP in critical care patients; and (vi) the panel suggested that the use of SD-plasma can be cost-effective with respect to the use of FFP.
  
  
  
  Data from additional randomised studies are needed to establish more definitive guidelines on the use of SD-plasma.
authors.affiliation: Department of Oncology, Haematology and Respiratory Diseases, University Hospital, Modena, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Marietta
authors.affiliation: Department of Haematology and Transfusion Medicine, "Carlo Poma" Hospital, Mantua, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.affiliation: Liver Transplant Anaesthesia and Critical Care Medicine, University Hospital "Nuovo Santa Chiara", Pisa, Italy.
authors.forename: M Lucia
authors.initials: ML
authors.lastname: Bindi
authors.affiliation: Immunohaematology and Transfusion Medicine Service, "S. Salvatore" Hospital, Pesaro, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Picardi
authors.affiliation: Postgraduate School of Health Economics and Management (Altems) and Istitute of Economic Policy, Catholic University of the Sacred Hearth, Roma, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Ruggeri
authors.affiliation: Immunohaematology and Transfusion Medicine, University Hospital, Padua, Italy.
authors.forename: Giustina
authors.initials: G
authors.lastname: De Silvestro