title: [Synthesis and Neurotropic Activity of 2,4-pyrano[4',3':4,5]pyrido[2,3-b]thieno[3,2-d] Pyrimidines].
abstract: 2,4-Disubstituted derivatives of pyrano[4',3':4,5]pyrido[2,3-b]thieno[3,2-d] pyrimidines were synthesized and their pharmacological studies was carried out at animals by the tests of antagonism with subcutaneous administration of corazol and behavior of "open field" model. The method of "rotating rod" was used to evaluate of neurotoxicity. The neurotropic properties were found in the new synthesized compounds. The new synthesized compounds as well as diazepam prevented the occurrence of clonic twitchings and clonic corazol seizures in animals. However, the studied compounds in contrast of tranquilizer diazepam having the anxiolytic and activating effects in the test of "open field", induced a oppressive behavior sedative effects.
authors.forename: E G
authors.initials: EG
authors.lastname: Paronikyan
authors.forename: Sh Sh
authors.initials: ShSh
authors.lastname: Dashyan
authors.forename: A S
authors.initials: AS
authors.lastname: Noravyan
authors.forename: I A
authors.initials: IA
authors.lastname: Dzhagatspanyan
authors.forename: R G
authors.initials: RG
authors.lastname: Paronikyan
authors.forename: I M
authors.initials: IM
authors.lastname: Nazaryan
authors.forename: A G
authors.initials: AG
authors.lastname: Akopyan
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D010433:Pentylenetetrazole / Q000009:adverse effects / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D011743:Pyrimidines; D010433:Pentylenetetrazole