title: Tailored Mesoporous Silica Nanoparticles for Controlled Drug Delivery: Platform Fabrication, Targeted Delivery, and Computational Design and Analysis.
abstract: Mesoporous silica nanoparticles (MSNs) are exceptionally promising drug carriers for controlled drug delivery systems because their morphology, pore structure, pore volume and pore size can be well tailored to obtain certain drug release profiles. Moreover, they possess the ability to specifically transport and deliver anti-cancer drugs when targeting molecules are properly grafted onto their surface. MSNs based drug delivery systems have the potential to revolutionize cancer therapy. This review provides a comprehensive overview of the fabrication, modification of MSNs and their applications in tumour-targeted delivery. In addition, the characterization and analysis of MSNs with computer aided strategies were described. The existing issues and future prospective concerning the applications of MSNs as drug carriers for controlled drug delivery systems were discussed.
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: She
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Lijue
authors.initials: L
authors.lastname: Chen
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Yi
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Chengpeng
authors.initials: C
authors.lastname: Li
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Canzhong
authors.initials: C
authors.lastname: He
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Feng
authors.affiliation: School of Medicine, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: School of Medicine, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Sarah
authors.initials: S
authors.lastname: Shigdar
authors.affiliation: School of Medicine, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Duan
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Lingxue
authors.initials: L
authors.lastname: Kong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D017076:Computer-Aided Design; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D012822:Silicon Dioxide
keywords: Computational design; controlled release; mesoporous silica
  nanoparticles (MSN); mesoporous silica nanoparticles; nanocarriers; targeted drug delivery.