title: Biotin decorated PLGA nanoparticles containing SN-38 designed for cancer therapy.
abstract: Active targeted chemotherapy is expected to provide more specific delivery of cytotoxic drugs to the tumor cells and hence reducing the side effects on healthy tissues. Due to the over expression of biotin receptors on cancerous cells as a result of further requirement for rapid proliferations, biotin can be a good candidate as a targeting agent. In this study, biotin decorated PLGA nanoparticles (NPs) containing SN-38 were prepared and in vitro studies were evaluated for their improved anti-cancer properties. In conclusion, biotin targeted PLGA NPs containing SN-38 showed preferential anticancer properties against tumor cells with biotin receptor over expression.
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Mozhdeh
authors.initials: M
authors.lastname: Mehdizadeh
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.|b Nano Alvand Co., Avicenna Tech Park, Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Hasti
authors.initials: H
authors.lastname: Rouhani
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.|b Nano Alvand Co., Avicenna Tech Park, Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Sepehri
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.|c Nanotechnology Research Centre, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Reyhaneh
authors.initials: R
authors.lastname: Varshochian
authors.affiliation: d Department of Toxicology-Pharmacology, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Ghahremani
authors.affiliation: e Department of Medicinal Chemistry, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amini
authors.affiliation: d Department of Toxicology-Pharmacology, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Gharghabi
authors.affiliation: d Department of Toxicology-Pharmacology, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Seyed Nasser
authors.initials: SN
authors.lastname: Ostad
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.|c Nanotechnology Research Centre, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Atyabi
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Azin
authors.initials: A
authors.lastname: Baharian
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.|c Nanotechnology Research Centre, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
authors.forename: Rassoul
authors.initials: R
authors.lastname: Dinarvand
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001692:Biological Transport; D001710:Biotin / Q000737:chemistry* / Q000378:metabolism; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004339:Drug Compounding; D065546:Drug Liberation; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000077146:Irinotecan; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D001710:Biotin; D000077146:Irinotecan; D002166:Camptothecin
keywords: Active targeted; anti-cancer; cytotoxic; in vitro