title: Comparing attitudes of younger and older patients towards cancer clinical trials.
abstract: To determine the attitudes of patients towards cancer clinical trials (CCTs) and assess the differences between older and younger patients.
  
  
  
  Patients with cancer, receiving treatment or in follow-up in University Hospital Waterford, Ireland were eligible. Patients completed a self-administered questionnaire. To determine attitudes towards CCTs, patients indicated their preference if offered participation in three hypothetical studies (cancer prevention/screening trial; CCT comparing standard to new treatment; a trial of new drug where no standard exists). Patients' reasons to or not to participate in CCTs were explored.
  
  
  
  From May 2014 to March 2015, 219 patients were accrued, 119 <65years and 100 ≥65years. Twenty-two (18%) younger and 4 (4%) older patients had been/were actively enrolled on a CCT (p=0.0012). No older patient and 5 (4%) of younger patients had enquired about CCT availability. For the CCT questions, 85 (71%) younger vs 57 (57%) older patients would participate in a prevention/screening CCT (p=0.033); 60 (50%) vs 44 (44%) for standard vs new drug (p=0.415), and 83 (69%) vs 78 (78%) for a CCT where no standard exists (p=0.218). The most common reason to participate in a CCT was a recommendation from the oncologist -98% <65years vs 87% ≥65years (p=0.001), with health problems being the leading reason not to participate, 86% vs 72% (p=0.01), respectively.
  
  
  
  Older and younger patients in this study gave similar importance to reasons for and against participation in CCTs. Most patients did not actively seek out a CCT, which may reflect a lack of awareness and a need for better education.
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Olubukola
authors.initials: O
authors.lastname: Ayodele
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Mateen
authors.initials: M
authors.lastname: Akhtar
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Aiste
authors.initials: A
authors.lastname: Konenko
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Niamh
authors.initials: N
authors.lastname: Keegan
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Flordeliza
authors.initials: F
authors.lastname: Calacsan
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Lesley
authors.initials: L
authors.lastname: Duggan
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Miriam
authors.initials: M
authors.lastname: O'Connor
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Paula
authors.initials: P
authors.lastname: Calvert
authors.affiliation: Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Canada.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Townsley
authors.affiliation: Department of Medical Oncology, South East Cancer Centre, University Hospital Waterford, Ireland.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Horgan
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001294:Attitude to Health; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D057240:Patient Preference; D011795:Surveys and Questionnaires
keywords: Attitudes; Clinical trials; Older patients