title: Tail of Superficial Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma After Preoperative Radiotherapy.
abstract: OBJECTIVE
  Superficial myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are highly associated with infiltrative growth (tail sign) and local recurrence, but the impact of preoperative radiotherapy is uncertain.
  
  
  METHODS
  Eight consecutive superficial MFS and 10 superficial UPS cases treated with preoperative radiotherapy and surgery were reviewed. Pathological response, surgical margin and magnetic resonance imaging (MRI) were retrospectively evaluated. Oncological events were reported in a descriptive form.
  
  
  RESULTS
  Pathologically, nearly-complete response was observed in six UPS cases. Tail sign was pathologically detected in 13 cases, eight of which remained viable. Among the eight cases with viable tail, three cases, including two with positive margin, locally recurred. No major discrepancy was observed between tail length on pre-treatment T1-weighted post-contrast, fat-saturated MRI and pathological tail length.
  
  
  CONCLUSIONS
  Tail of superficial MFS and UPS can retain viability even after radiotherapy and cause local recurrence unless they respond to radiotherapy well. Wider resection including the tail on MRI is recommended.
authors.affiliation: Department of Orthopaedics, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia Department of Orthopaedic Oncology and Surgery, Saitama Medical University International Medical Center, Saitama, Japan Department of Surgery, University of Melbourne, Fitzroy, Victoria, Australia.
authors.forename: Jungo
authors.initials: J
authors.lastname: Imanishi
authors.affiliation: Department of Pathology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Slavin
authors.affiliation: Department of Medical Imaging, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
authors.forename: Marcus
authors.initials: M
authors.lastname: Pianta
authors.affiliation: Department of Pathology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
authors.forename: Louise
authors.initials: L
authors.lastname: Jackett
authors.affiliation: Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, East Melbourne, Victoria, Australia.
authors.forename: Samuel Y
authors.initials: SY
authors.lastname: Ngan
authors.affiliation: Department of Orthopaedics, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Orthopaedics, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: Charoenlap
authors.affiliation: Department of Orthopaedics, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia Department of Surgery, University of Melbourne, Fitzroy, Victoria, Australia.
authors.forename: Claudia
authors.initials: C
authors.lastname: DI Bella
authors.affiliation: Department of Orthopaedics, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia Department of Surgery, University of Melbourne, Fitzroy, Victoria, Australia Bone and Soft Tissue Tumour Unit, Peter MacCallum Cancer Centre, East Melbourne, East Melbourne, Victoria, Australia sarcoma@bigpond.net.au pchoong@unimelb.edu.au.
authors.forename: Peter F M
authors.initials: PF
authors.lastname: Choong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005354:Fibrosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D011300:Preoperative Care; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Soft-tissue sarcoma; infiltration; radiotherapy; recurrence; surgical margin