title: INDIVIDUALISED CALCULATION OF TISSUE IMPARTED ENERGY IN BREAST TOMOSYNTHESIS.
abstract: The imparted energy to the glandular tissue in the breast (glandular imparted energy, GIE) is proposed for an improved assessment of the individual radiation-induced risk resulting from X-ray breast imaging. GIE is computed from an estimation of the quantity and localisation of glandular tissue in the breast. After a digital breast tomosynthesis (DBT) acquisition, the volumetric glandular content (volumetric breast density, VBD) is computed from the central X-ray projection. The glandular tissue distribution is determined by labelling the DBT voxels to ensure the conservation of the VBD. Finally, the GIE is calculated by Monte Carlo computation on the resulting tissue-labelled DBT volume. For verification, the method was applied to 10 breast-shaped digital phantoms made of different glandular spheres in an adipose background, and to a digital anthropomorphic phantom. Results were compared to direct GIE computations on the phantoms considered as 'ground-truth'. The major limitations in accuracy are those of DBT, in particular the limited z-resolution. However, for most phantoms, the results can be considered as acceptable.
authors.affiliation: Digital Guidance Solutions, GE Healthcare, 283 rue de la Minière, 78530 Buc, France Department of Radiology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium Institut Mines-Télécom, Télécom ParisTech, CNRS LTCI, 46 rue Barrault, 75013 Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Geeraert
authors.affiliation: Digital Guidance Solutions, GE Healthcare, 283 rue de la Minière, 78530 Buc, France remy.klausz@ge.com.
authors.forename: R
authors.initials: R
authors.lastname: Klausz
authors.affiliation: Digital Guidance Solutions, GE Healthcare, 283 rue de la Minière, 78530 Buc, France.
authors.forename: S
authors.initials: S
authors.lastname: Muller
authors.affiliation: Institut Mines-Télécom, Télécom ParisTech, CNRS LTCI, 46 rue Barrault, 75013 Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Bloch
authors.affiliation: Department of Radiology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Bosmans
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000465:Algorithms; D000886:Anthropometry; D001940:Breast / Q000000981:diagnostic imaging*; D002138:Calibration; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008327:Mammography / Q000379:methods*; D009010:Monte Carlo Method; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D014965:X-Rays