title: Reciprocal interactions between circadian clocks and aging.
abstract: Virtually, all biological processes in the body are modulated by an internal circadian clock which optimizes physiological and behavioral performance according to the changing demands of the external 24-h world. This circadian clock undergoes a number of age-related changes, at both the physiological and molecular levels. While these changes have been considered to be part of the normal aging process, there is increasing evidence that disruptions to the circadian system can substantially impact upon aging and these impacts will have clear health implications. Here we review the current data of how both the physiological and core molecular clocks change with age and how feedback from external cues may modulate the aging of the circadian system.
authors.affiliation: MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK. g.banks@har.mrc.ac.uk.
authors.forename: Gareth
authors.initials: G
authors.lastname: Banks
authors.affiliation: MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Nolan
authors.affiliation: Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, South Parks Road, Oxfordshire, OX1 3RE, UK.
authors.forename: Stuart N
authors.initials: SN
authors.lastname: Peirson
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology; D057906:Circadian Clocks / Q000235:genetics* / Q000502:physiology; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006801:Humans