title: Relationship between dyslipidemia and carotid plaques in a high-stroke-risk population in Shandong Province, China.
abstract: The precise associations between stroke and carotid plaques and dyslipidemia are unclear. This population-based study aimed to examine the relationship between carotid plaques and dyslipidemia in a high-stroke-risk population.
  
  
  
  Ultrasonography of left and right carotid arteries was conducted in 22,222 participants in a second screening survey of individuals with high stroke risk. Subjects were divided into two groups according to the presence or absence of carotid plaques. Blood TC (total cholesterol), TG (total triglycerides), and LDL-C (low-density lipoprotein cholesterol) levels were recorded.
  
  
  
  Multivariate logistic regression analysis, controlled for gender, age, education, geographic region, smoking, exercise, and overweight (Model 2), identified TG as a predictor of carotid-plaque risk (odds ratio [OR] = 1.109, 95% confidence interval [CI]: 1.038-1.185, P = 0.002), and the association between carotid plaques and LDL-C (OR = 0.967, 95%CI: 0.949-0.994, P = 0.019) was less significant, whereas there was no association between carotid plaques and TC (OR = 1.002, 95%CI: 0.932-1.007, P = 0.958). After additional adjustment for hypertension, diabetes, and atrial fibrillation (Model 3), TG remained a risk factor for carotid plaques (OR = 1.086, 95%CI: 1.016-1.161, P = 0.015), but no associations were observed between carotid plaques and LDL-C (OR = 0.972, 95%CI: 0.910-1.038, P = 0.394) or TC (OR = 1.003, 95%CI: 0.933-1.079, P = 0.928). Only the association between TG and carotid plaques (OR = 1.084, 95%CI: 1.014-1.159, P = 0.017) was independent of all covariates (covariates in Model 3 plus history of stroke or transient ischemic attack, and stroke family history) in Model 4.
  
  
  
  These findings indicate that TG was an independent risk factor for carotid plaques in high-risk population for stroke, whereas LDL-C and TC were not associated with the appearance of carotid plaques independently.
authors.affiliation: Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Te
authors.initials: T
authors.lastname: Mi
authors.affiliation: Cardio-Cerebrovascular Control and Research Center Institute of Basic Medicine Shandong Academy of Medical Sciences Jinan Shandong 250062 China.
authors.forename: Shangwen
authors.initials: S
authors.lastname: Sun
authors.affiliation: Neurology Department Weifang Chinese Medicine Hospital Weifang Shandong 261041 China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Neurosurgery Department Wayne State University School of Medicine Detroit Michigan 48201 China.
authors.forename: Yaser
authors.initials: Y
authors.lastname: Carora
authors.affiliation: Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Du
authors.affiliation: Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Shougang
authors.initials: S
authors.lastname: Guo
authors.affiliation: Medical Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Cao
authors.affiliation: Medical Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Qinjian
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
authors.forename: Chuanqiang
authors.initials: C
authors.lastname: Qu
mesh_terms: D000368:Aged; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*
keywords: Carotid plaque; dyslipidemia; stroke