title: Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.
abstract: Clinical activity and quality of life (QOL) indices assess disease activity in Crohn's disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics.
  
  
  
  To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics.
  
  
  
  We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey-Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics.
  
  
  
  Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and -0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04).
  
  
  
  Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes.
authors.affiliation: Division of Gastroenterology, University of Arizona College of Medicine, Tucson, AZ, 85724, USA. staleban@yahoo.com.|Department of Medicine, University of Arizona Center of Aging, Tucson, AZ, 85724, USA. staleban@yahoo.com.|Section of Gastroenterology, Banner University Medical Center, 1501 N. Campbell Ave, Tucson, AZ, 85724, USA. staleban@yahoo.com.
authors.forename: Sasha
authors.initials: S
authors.lastname: Taleban
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Kathleen O
authors.initials: KO
authors.lastname: Stewart
authors.affiliation: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Darrick K
authors.initials: DK
authors.lastname: Li
authors.affiliation: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Prashant
authors.initials: P
authors.lastname: Singh
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Darrell S
authors.initials: DS
authors.lastname: Pardi
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Holly C
authors.initials: HC
authors.lastname: Sturgeon
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Yajnik
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.|The Broad Institute, Cambridge, MA, 02124, USA.|Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.
authors.forename: Ramnik J
authors.initials: RJ
authors.lastname: Xavier
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.|Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Ashwin N
authors.initials: AN
authors.lastname: Ananthakrishnan
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. hkhalili@mgh.harvard.edu.|Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. hkhalili@mgh.harvard.edu.|Crohn's and Colitis Center, Massachusetts General Hospital, 165 Cambridge Street, 9th Floor, Boston, MA, 02114, USA. hkhalili@mgh.harvard.edu.
authors.forename: Hamed
authors.initials: H
authors.lastname: Khalili
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000473:pathology / Q000503:physiopathology*; D003424:Crohn Disease / Q000473:pathology / Q000503:physiopathology*; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011788:Quality of Life; D012042:Registries; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Crohn’s disease; Inflammatory bowel disease; Quality of life; Ulcerative colitis