title: Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury: mechanisms of brain tissue repair.
abstract: Buyanghuanwu decoction has been shown to protect against cerebral ischemia/reperfusion injury, but the underlying mechanisms remain unclear. In this study, rats were intragastrically given Buyanghuanwu decoction, 15 mL/kg, for 3 days. A rat model of cerebral ischemia/reperfusion injury was established by middle cerebral artery occlusion. In rats administered Buyanghuanwu decoction, infarct volume was reduced, serum vascular endothelial growth factor and integrin αvβ3 levels were increased, and brain tissue vascular endothelial growth factor and CD34 expression levels were increased compared with untreated animals. These effects of Buyanghuanwu decoction were partially suppressed by an angiogenesis inhibitor (administered through the lateral ventricle for 7 consecutive days). These data suggest that Buyanghuanwu decoction promotes angiogenesis, improves cerebral circulation, and enhances brain tissue repair after cerebral ischemia/reperfusion injury.
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
authors.forename: Zhen-Qiang
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Song
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
authors.forename: Ya-Quan
authors.initials: YQ
authors.lastname: Jia
authors.affiliation: First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
authors.forename: Yun-Ke
authors.identifier: 0000-0003-1500-1535
authors.initials: YK
authors.lastname: Zhang
keywords: Buyanghuanwu decoction; CD34; angiogenesis; cerebral ischemia/reperfusion injury; integrin αvβ3; ischemic cerebrovascular disease; nerve regeneration; neural regeneration; vascular endothelial growth factor