title: A novel marker in pregnant with preeclampsia: renalase.
abstract: BACKGROUND
  Preeclampsia is characterized by an increase in high blood pressure and decrease in GFR and proteinuria, however, the underlying mechanisms are still unclear. Renalase is a recently discovered protein implicated in regulation of blood pressure in humans.
  
  
  METHODS
  Plasma concentrations of serum renalase were measured in healthy controls, healthy pregnant and pregnant with preeclampsia matched for age, gestational age, in the third trimester of pregnancy. Serum renalase levels were compared in pregnant with and without preeclampsia and non-pregnant controls. Factors associated with serum renalase levels in pregnancies were also evaluated.
  
  
  RESULTS
  In healthy pregnant serum renalase levels were significantly higher than in controls. However, pregnant with preeclampsia had lower renalase levels than healthy controls. Serum renalase levels were inversely associated with blood pressure levels and positively correlated with glomerular filtration rate.
  
  
  CONCLUSIONS
  The results indicated that the development of preeclampsia in pregnant is accompanied by altered serum renalase levels. High blood pressure and kidney damage that characterize this disorder are mediated at least in part by low renalase levels.
authors.affiliation: a Department of Obstetrics and Gynaecology , Dr. Sami Ulus Women's and Children's Health Training and Research Hospital , Ankara , Turkey , and.
authors.forename: Zehra Vural
authors.initials: ZV
authors.lastname: Yılmaz
authors.affiliation: a Department of Obstetrics and Gynaecology , Dr. Sami Ulus Women's and Children's Health Training and Research Hospital , Ankara , Turkey , and.
authors.forename: Elif
authors.initials: E
authors.lastname: Akkaş
authors.affiliation: b Nephrology Department, Faculty of Medicine, Hacettepe University , Ankara , Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Yıldırım
authors.affiliation: b Nephrology Department, Faculty of Medicine, Hacettepe University , Ankara , Turkey.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Yılmaz
authors.affiliation: b Nephrology Department, Faculty of Medicine, Hacettepe University , Ankara , Turkey.
authors.forename: Yunus
authors.initials: Y
authors.lastname: Erdem
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology; D007674:Kidney Diseases / Q000150:complications; D008995:Monoamine Oxidase / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008995:Monoamine Oxidase; C521557:renalase
keywords: Hypertension; preeclampsia; pregnancy; renalase