title: Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates.
abstract: Enantioselective intramolecular conjugate addition reactions of short-lived C-O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% enantiomeric excess (ee).
authors.affiliation: Institute for Chemical Research, Kyoto University.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tomohara
authors.forename: Koji
authors.initials: K
authors.lastname: Kasamatsu
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Takumi
authors.initials: T
authors.lastname: Furuta
authors.forename: Takeo
authors.initials: T
authors.lastname: Kawabata
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D001572:Benzofurans; D007659:Ketones