title: Anticancer Molecular Mechanisms of Resveratrol.
abstract: Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only significantly present in grape products, a huge amount of preclinical studies investigated its anticancer properties in a plethora of cellular and animal models. Molecular mechanisms of resveratrol involved signaling pathways related to extracellular growth factors and receptor tyrosine kinases; formation of multiprotein complexes and cell metabolism; cell proliferation and genome instability; cytoplasmic tyrosine kinase signaling (cytokine, integrin, and developmental pathways); signal transduction by the transforming growth factor-β super-family; apoptosis and inflammation; and immune surveillance and hormone signaling. Resveratrol also showed a promising role to counteract multidrug resistance: in adjuvant therapy, associated with 5-fluoruracyl and cisplatin, resveratrol had additive and/or synergistic effects increasing the chemosensitization of cancer cells. Resveratrol, by acting on diverse mechanisms simultaneously, has been emphasized as a promising, multi-target, anticancer agent, relevant in both cancer prevention and treatment.
authors.affiliation: Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano , Milan , Italy.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Varoni
authors.affiliation: Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano , Milan , Italy.
authors.forename: Alfredo Fabrizio
authors.initials: AF
authors.lastname: Lo Faro
authors.affiliation: Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Sharifi-Rad
authors.affiliation: Dipartimento di Scienze Agrarie e Ambientali, Università degli Studi di Milano , Milan , Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Iriti
keywords: bioavailability; cancer chemoprevention; multi-target agents; nutritional therapy; polyphenols; stilbenes