title: Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report.
abstract: The interpretation of supernumerary chromosome is important for genetic counseling and prognosis. Here, we used SNP array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the Neonatal Intensive Care Unit of Shahid Sadoughi Hospital in 2015. Clinical abnormalities identified in the newborn were dysmorphic face, intrauterine growth retardation, atrial septal defect (ASD), the hypoplasia of corpus callosum and septum pellucidum. These clinical abnormalities can be related to this marker, and it may help genetic counselor for predicting abnormality risk in susceptible individuals as well as prenatal diagnosis.
authors.affiliation: Medical Genetics Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Dept. of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Yahya
authors.initials: MY
authors.lastname: Vahidi Mehrjardi
authors.affiliation: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Dehghan Tezerjani
authors.affiliation: Dept. of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Nori-Shadkam
authors.affiliation: Dept. of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Kalantar
authors.affiliation: Medical Genetics Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Dehghani
keywords: Karyotype; Partial trisomy 11; Partial trisomy 22; SNP array; Supernumerary marker chromosomes