title: Post-caesarean section surgical site infections at a Tanzanian tertiary hospital: a prospective observational study.
abstract: Few data are available on the determinants and characteristics of post-caesarean section (CS) surgical site infections (SSIs) in resource-limited settings. We conducted a prospective observational cohort study to evaluate the rates, determinants, and microbiological characteristics of post-CS SSI at the Dodoma Regional Referral Hospital (DRRH) Gynaecology and Obstetrics Department in Tanzania. Spanning a three-month period, all pregnant women who underwent CS were enrolled and followed up for 30 days. SSI following CS occurred in 224 (48%) women. Only 10 (2.1%) women received pre-incision antibiotic prophylaxis. Urgent intervention is needed to prevent and control infections and contain the rising rate of post-CS SSI at the DRRH.
authors.affiliation: Resource Centre for Infectious Diseases, Dodoma Regional Referral Hospital, Dodoma, Tanzania; 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy. Electronic address: pasquale.denardo@inmi.it.
authors.forename: P
authors.initials: P
authors.lastname: De Nardo
authors.affiliation: Resource Centre for Infectious Diseases, Dodoma Regional Referral Hospital, Dodoma, Tanzania; Department of Infectious Diseases, Tor Vergata University Hospital, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Gentilotti
authors.affiliation: Resource Centre for Infectious Diseases, Dodoma Regional Referral Hospital, Dodoma, Tanzania; 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Nguhuni
authors.affiliation: 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Vairo
authors.affiliation: Resource Centre for Infectious Diseases, Dodoma Regional Referral Hospital, Dodoma, Tanzania.
authors.forename: Z
authors.initials: Z
authors.lastname: Chaula
authors.affiliation: 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Nicastri
authors.affiliation: Resource Centre for Infectious Diseases, Dodoma Regional Referral Hospital, Dodoma, Tanzania.
authors.forename: M M
authors.initials: MM
authors.lastname: Nassoro
authors.affiliation: 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Bevilacqua
authors.affiliation: University of Dodoma - UDOM, Department of Statistics, Dodoma, Tanzania.
authors.forename: A
authors.initials: A
authors.lastname: Ismail
authors.affiliation: Resource Centre for Infectious Diseases, Dodoma Regional Referral Hospital, Dodoma, Tanzania; Department of Health Sciences, Clinic of Infectious Diseases, 'San Paolo' Hospital, University of Milan, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Savoldi
authors.affiliation: Division of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre at UCL Hospitals NHS Foundation Trust, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Zumla
authors.affiliation: 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ippolito
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis / Q000706:statistics & numerical data; D002585:Cesarean Section / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology*; D013636:Tanzania / Q000453:epidemiology; D062606:Tertiary Care Centers; D055815:Young Adult
keywords: Antibiotic prophylaxis; Antimicrobial resistance; Caesarean section; Pregnant women; Resource-limited settings; Surgical site infection