title: Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging.
abstract: Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (SB, n=36) and healthy controls (HC, n=47). SZ had shorter TL compared to HC, but no difference was found in SB comparing to SZ. These findings indicate that a pathological accelerated aging profile could be present in the course of SZ and further studies are needed to confirm TL as potential endophenotype, especially in at risk populations.
authors.affiliation: Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Leticia Sanguinetti
authors.initials: LS
authors.lastname: Czepielewski
authors.affiliation: Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Departamento de Psiquiatria, Universidade Federal do Paraná, Curitiba, Brazil.
authors.forename: Raffael
authors.initials: R
authors.lastname: Massuda
authors.affiliation: Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Panizzutti
authors.affiliation: Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Eduarda Dias
authors.initials: ED
authors.lastname: da Rosa
authors.affiliation: Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Brazil.
authors.forename: David
authors.initials: D
authors.lastname: de Lucena
authors.affiliation: Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Brazil.
authors.forename: Danielle
authors.initials: D
authors.lastname: Macêdo
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Lucas Kich
authors.initials: LK
authors.lastname: Grun
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Florencia María
authors.initials: FM
authors.lastname: Barbé-Tuana
authors.affiliation: Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: cgama@hcpa.edu.br.
authors.forename: Clarissa Severino
authors.initials: CS
authors.lastname: Gama
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015992:Body Mass Index; D004522:Educational Status; D058068:Endophenotypes; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D035781:Siblings; D016615:Telomere / Q000378:metabolism; D059506:Telomere Shortening; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents
keywords: Accelerated aging; Biomarkers; Endophenotypes; Schizophrenia; Telomere length