title: Fusogen-assisted rapid reconstitution of anatomophysiologic continuity of the transected spinal cord.
abstract: The GEMINI spinal cord fusion protocol exploits the ability of so-called fusogens, such as polyethylene glycol (PEG), to achieve rapid neural restoration of electrical continuity across the ends of a transected spinal cord. Experimental evidence suggests that motor recovery can occur after complete transection of the cervical and dorsal spinal cord in mice and rats following application of PEG. This allows for the possibility of spinal cord "reconstruction" in humans and even the possibility of head transplantation in the future.
authors.affiliation: Hand and Microsurgical Center, 2nd Affiliated Hospital, Harbin Medical University, Harbin, China; State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China.
authors.forename: Yijie
authors.initials: Y
authors.lastname: Ye
authors.affiliation: College of Life Science, Department of Bioengineering, CHA University, Seoul, Korea; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
authors.forename: C-Yoon
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Hand and Microsurgical Center, 2nd Affiliated Hospital, Harbin Medical University, Harbin, China; State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Miao
authors.affiliation: Hand and Microsurgical Center, 2nd Affiliated Hospital, Harbin Medical University, Harbin, China; State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China. Electronic address: chinarenxg@126.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Ren
mesh_terms: D000818:Animals; D009043:Motor Activity; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000601:surgery*; D058630:Spinal Cord Regeneration / Q000187:drug effects*; D013501:Surface-Active Agents / Q000627:therapeutic use*
chemical_list: D013501:Surface-Active Agents; D011092:Polyethylene Glycols