title: Mechanics of epithelial tissues during gap closure.
abstract: The closure of gaps is crucial to maintaining epithelium integrity during developmental and repair processes such as dorsal closure and wound healing. Depending on biochemical as well as physical properties of the microenvironment, gap closure occurs through assembly of multicellular actin-based contractile cables and/or protrusive activity of cells lining the gap. This review discusses the relative contributions of 'purse-string' and cell crawling mechanisms regulated by cell-substrate and cell-cell interactions, cellular mechanics and physical constraints from the environment.
authors.affiliation: Institut Jacques Monod (IJM), CNRS UMR 7592 & University Paris Diderot, Paris, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Begnaud
authors.affiliation: Mechanobiology Institute (MBI), National University of Singapore, Singapore.
authors.forename: Tianchi
authors.initials: T
authors.lastname: Chen
authors.affiliation: Institut Jacques Monod (IJM), CNRS UMR 7592 & University Paris Diderot, Paris, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Delacour
authors.affiliation: Institut Jacques Monod (IJM), CNRS UMR 7592 & University Paris Diderot, Paris, France. Electronic address: rene-marc.mege@ijm.fr.
authors.forename: René-Marc
authors.initials: RM
authors.lastname: Mège
authors.affiliation: Institut Jacques Monod (IJM), CNRS UMR 7592 & University Paris Diderot, Paris, France; Mechanobiology Institute (MBI), National University of Singapore, Singapore. Electronic address: benoit.ladoux@ijm.fr.
authors.forename: Benoît
authors.initials: B
authors.lastname: Ladoux
mesh_terms: D000199:Actins; D000205:Actomyosin / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D019521:Body Patterning; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D004848:Epithelium / Q000502:physiology*; D006801:Humans
chemical_list: D000199:Actins; D000205:Actomyosin