title: Production of 68Ga-citrate Based on a SnO2 Generator for Short-Term Turpentine Oil-Induced Inflammation Imaging in Rats.
abstract: BACKGROUND
  Gallium-68 citrate has been successfully applied in the PET imaging of infections and inflammation in some centers; however further evaluation of the tracer in inflammation models is of great importance.
  
  
  METHODS
  68Ga-citrate prepared from [68Ga]GaCl3 (eluted form an SnO2 based 68Ge/68Ga generator) and sodium citrate at optimized conditions followed by quality control tests was injected to normal and turpentine-oil induced rats PET/CT imaging studies up to 290 min.
  
  
  RESULTS
  68Ga-citrate was prepared with acceptable radiochemical purity (>99 ITLC, >99% HPLC), specific activity (28-30 GBq/mM), chemical purity (Sn, Fe <0.3 ppm; Zn<0.2 ppm) in 15 min at 50°C. PET/CT imaging of the tracer demonstrated early detection of inflamed site in animal models in 60-80 min.
  
  
  CONCLUSIONS
  This study demonstrated possible early detection of inflammation foci in vivo using 68Ga-citrate prepared using commercially available 68Ge/68Ga generators for PET imaging.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mirzaei
authors.affiliation: Nuclear Science and Technology Research Institute, Postal code: 141551339 Tehran, Iran.
authors.forename: Amir R
authors.initials: AR
authors.lastname: Jalilian
authors.forename: Mehdi
authors.initials: M
authors.lastname: Akhlaghi
authors.forename: Davood
authors.initials: D
authors.lastname: Beiki
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002951:Citrates / Q000138:chemical synthesis*; D005710:Gallium Radioisotopes / Q000737:chemistry*; D005857:Germanium / Q000737:chemistry*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017971:Tin Compounds / Q000737:chemistry*; D014425:Turpentine
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D017971:Tin Compounds; D005857:Germanium; D014425:Turpentine
keywords: 68Ga-citrate; PET/CT; nuclids.; quality control; rats; turpentine oil