title: A prospective study of autoantibodies to Ezrin and pancreatic cancer risk.
abstract: No biomarker is available for pancreatic cancer early detection, but a small prospective European study involving 16 cases and 32 controls raised the possibility that anti-Ezrin autoantibodies may be associated with risk of pancreatic cancer. We aimed to validate this finding in a case-control study nested within a prospective study in the USA.
  
  
  
  Levels of anti-Ezrin autoantibodies were examined using ELISA in pre-diagnostic plasma samples of 73 cases and 145 matched controls. Paired t test and paired signed rank tests were used to determine the difference between two groups, and conditional logistic regression was used to evaluate the association between anti-Ezrin autoantibody levels and risk of developing pancreatic cancer.
  
  
  
  No association was found between levels of anti-Ezrin plasma autoantibodies and subsequent risk of developing pancreatic cancer.
  
  
  
  Anti-Ezrin autoantibodies did not appear to be useful as a plasma biomarker for early detection of pancreatic cancer.
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.|Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.
authors.forename: Shuyang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.|West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Qiaolan
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.|International Epidemiology Institute, Rockville, MD, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Blot
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.
authors.forename: Xiao Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA. qiuyin.cai@vanderbilt.edu.
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D016022:Case-Control Studies; D003598:Cytoskeletal Proteins / Q000276:immunology*; D055088:Early Detection of Cancer; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000276:immunology*; D011446:Prospective Studies; D012306:Risk; D014481:United States / Q000453:epidemiology; D000099149:Ezrin
chemical_list: D001323:Autoantibodies; D003598:Cytoskeletal Proteins; D000099149:Ezrin
keywords: Autoantibodies; Ezrin; Pancreatic cancer risk; Prospective study