title: Low-to-Moderate Alcohol Consumption is Associated With Hippocampal Volume in Fibromyalgia and Insomnia.
abstract: Fibromyalgia and chronic insomnia are frequently comorbid conditions with heightened sensitivity to painful stimuli, potentially subserved by the hippocampus. Recent evidence suggests moderate alcohol consumption is associated with reduced fibromyalgia symptom severity. We examined the relationship among alcohol use, hippocampal morphology, fibromyalgia, and insomnia symptom severity in 41 fibromyalgia patients (19 with insomnia). A 14-day diary of sleep, pain, and alcohol consumption was followed by structural MRI. Analyses indicated greater bilateral hippocampal volume, lower clinical pain intensity, and better sleep quality in moderate drinkers versus abstainers. Underlying mechanisms may include gamma-amino butyric acid (GABA) receptor agonism, n-methyl d-aspartate (NMDA) receptor antagonism, and psychosocial factors. Further study of the relationship between alcohol use and fibromyalgia and insomnia symptom severity is warranted.
authors.affiliation: a Pain Research and Intervention Center of Excellence , University of Florida , Gainesville , Florida.
authors.forename: Jeff
authors.initials: J
authors.lastname: Boissoneault
authors.affiliation: b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
authors.forename: Karlyn
authors.initials: K
authors.lastname: Vatthauer
authors.affiliation: b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
authors.forename: Andrew
authors.initials: A
authors.lastname: O'Shea
authors.affiliation: b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
authors.forename: Jason G
authors.initials: JG
authors.lastname: Craggs
authors.affiliation: a Pain Research and Intervention Center of Excellence , University of Florida , Gainesville , Florida.|b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
authors.forename: Michael
authors.initials: M
authors.lastname: Robinson
authors.affiliation: a Pain Research and Intervention Center of Excellence , University of Florida , Gainesville , Florida.|c Department of Medicine , University of Florida , Gainesville , Florida.
authors.forename: Roland
authors.initials: R
authors.lastname: Staud
authors.affiliation: c Department of Medicine , University of Florida , Gainesville , Florida.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Berry
authors.affiliation: b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
authors.forename: William
authors.initials: W
authors.lastname: Perlstein
authors.affiliation: b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
authors.forename: Lori
authors.initials: L
authors.lastname: Waxenberg
authors.affiliation: a Pain Research and Intervention Center of Excellence , University of Florida , Gainesville , Florida.|b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
authors.forename: Christina S
authors.initials: CS
authors.lastname: McCrae
mesh_terms: D000428:Alcohol Drinking / Q000503:physiopathology*; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000503:physiopathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010146:Pain / Q000150:complications / Q000503:physiopathology; D018079:Receptors, GABA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D012890:Sleep / Q000502:physiology; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications* / Q000503:physiopathology*
chemical_list: D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate