title: Serious Adverse Transfusion Reactions Reported in the National Recipient-Triggered Trace Back System in Korea (2006-2014).
abstract: BACKGROUND
  Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea.
  
  
  METHODS
  Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation.
  
  
  RESULTS
  Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction).
  
  
  CONCLUSIONS
  This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.
authors.affiliation: Division of Human Blood Safety Surveillance, Korea Centers for Disease Control & Prevention, Cheongju, Korea.
authors.forename: Jeong Ran
authors.initials: JR
authors.lastname: Kwon
authors.affiliation: Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Won
authors.affiliation: Division of Human Blood Safety Surveillance, Korea Centers for Disease Control & Prevention, Cheongju, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Jo
authors.affiliation: Division of Human Blood Safety Surveillance, Korea Centers for Disease Control & Prevention, Cheongju, Korea.
authors.forename: Sae Rom
authors.initials: SR
authors.lastname: Choi
authors.affiliation: Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Kyoungyul
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sinyoung
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hyeong Sik
authors.initials: HS
authors.lastname: Ahn
authors.affiliation: Division of Human Blood Safety Surveillance, Korea Centers for Disease Control & Prevention, Cheongju, Korea.
authors.forename: Young Sill
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunwan University School of Medicine, Seoul, Korea. duck.cho@samsung.com.
authors.forename: Duck
authors.initials: D
authors.lastname: Cho
authors.affiliation: Division of Infectious Disease Surveillance, Korea Centers for Disease Control & Prevention, Cheongju, Korea. ldhmd@korea.kr.
authors.forename: Dong Han
authors.initials: DH
authors.lastname: Lee
mesh_terms: D055371:Acute Lung Injury / Q000453:epidemiology / Q000209:etiology; D015658:HIV Infections / Q000453:epidemiology / Q000209:etiology; D006526:Hepatitis C / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008288:Malaria / Q000453:epidemiology / Q000209:etiology; D056910:Republic of Korea; D012189:Retrospective Studies; D065227:Transfusion Reaction / Q000209:etiology*
keywords: Adverse transfusion reactions; Hemovigilance system; Korea; Trace back system