title: Retinoids have therapeutic action in type 2 diabetes.
abstract: OBJECTIVE
  Uncontrolled diabetes is associated with a compromised antioxidant state of the body. Consequentially, the reactive oxygen species generated lead to oxidative insult and associated complications. Based on this paradigm, exogenous antioxidant supplementation is thought to exert a therapeutic role in type 2 diabetes (T2-D) biology.
  
  
  METHODS
  In the present study, the effect of vitamin A supplementation was assessed on disease progression in T2-D BALB/c mice. Animals were divided into three groups. With the exception of control, the mice in remaining groups were induced with experimental T2-D. After a 15-day treatment protocol, the mice were sacrificed and various parameters were analyzed.
  
  
  RESULTS
  The treated group evidenced a considerable improvement in total antioxidant potential and glycemic control. A therapeutic effect on beta cell degeneration as compared to the diabetic group was also found.
  
  
  CONCLUSIONS
  The study illustrates the antihyperglycemic and antioxidant potential of vitamin A in vivo, which has potential to serve as a dietary intervention in T2-D.
authors.affiliation: Department of Biochemistry, Aligarh Muslim University, Aligarh, India.
authors.forename: Dilnasheen
authors.initials: D
authors.lastname: Meerza
authors.affiliation: Department of Biochemistry, Aligarh Muslim University, Aligarh, India.
authors.forename: Sarah
authors.initials: S
authors.lastname: Iqbal
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India.
authors.forename: Sufian
authors.initials: S
authors.lastname: Zaheer
authors.affiliation: Department of Biochemistry, Aligarh Muslim University, Aligarh, India. Electronic address: Imrananaseem2009@gmail.com.
authors.forename: Imrana
authors.initials: I
authors.lastname: Naseem
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010084:Oxidation-Reduction / Q000187:drug effects; D012176:Retinoids / Q000494:pharmacology*; D014801:Vitamin A / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D012176:Retinoids; D014815:Vitamins; D014801:Vitamin A
keywords: DNA damage; Hyperglycemia; Oxidative stress; Type 2 diabetes; Vitamin A