title: CORRELATIONS BETWEEN ARTERIAL HYPERTENSION INDUCED BY ANGIOTENSIN II AND SYSTEMIC INFLAMMATION IN RAT.
abstract: Angiotensin II has articularly shown to play a key role in the regulation of inflammatory processes in hypertension.
  
  
  OBJECTIVE
  The present study aims to correlate the angiotensin II-induced hypertension 4th systemic inflammation.
  
  
  METHODS
  We conducted an experimental study on Wistar male rats who received Ang II via subcutaneous miniosmotic pumps for 2 weeks. Rats were exposed to a 12h light /12h dark cycle. Sham rats were used as control. Systolic load pressure measurements and a flow cytometric analysis of lymphocyte surface markers were performed. After 14 days, the animals were euthanized under anesthesia with ylazine/ketaniine.
  
  
  RESULTS
  Systolic BP progressively and significantly increased in rats 4th Ang II chronic infusion. We observed a statistical significant difference (p = 0.00001), in terms of T lymphocytes percentage between control rats plasma and Ang H treated rats lasma, in 14 days.
  
  
  CONCLUSIONS
  Angiotensin II is an important mediator of hypertension and directly promotes inflammation by noticeably increasing the quantity of T cells in kidney tissue.
authors.forename: Minela Aida
authors.initials: MA
authors.lastname: Mărănducă
authors.forename: Elena
authors.initials: E
authors.lastname: Cojocaru
authors.forename: Eugen
authors.initials: E
authors.lastname: Carasevici
mesh_terms: D000804:Angiotensin II; D000818:Animals; D004195:Disease Models, Animal; D006973:Hypertension / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D014662:Vasoconstrictor Agents
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II