title: Determination of 3-Monochloropropane-1,2-diol and 2-Monochloropropane-1,3-diol (MCPD) Esters and Glycidyl Esters by Microwave Extraction in Different Foodstuffs.
abstract: This paper describes a method for the determination of 3-monochloropropane-1,2-diol and 2-monochloropropane-1,3-diol (MCPD) esters and glycidyl esters in various foodstuffs, which are isolated using microwave extraction. The next step is based on alkaline-catalyzed ester cleavage. The released glycidol is transformed into monobromopropanediol (MBPD). All compounds are derivatized in free diols (MCPD and MBPD) with phenylboronic acid and analyzed by gas chromatography-mass spectrometry (GC-MS). The method was validated for oils with a limit of quantitation (LOQ) of 0.1 mg/kg, for chips and crisps with a LOQ of 0.02 mg/kg, and for infant formula with a LOQ of 0.0025 mg/L. Recoveries of each sample were controlled by standard addition on extracts before derivatization. Quantitation was performed by the addition of isotopically labeled glycidyl and 3-monochloropropane-1,2-diol (3-MCPD) esters.
authors.affiliation: Service Commun des Laboratoires , 25 Avenue de la République, 91744 Massy, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Marc
authors.affiliation: Service Commun des Laboratoires , 25 Avenue de la République, 91744 Massy, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Drouard-Pascarel
authors.affiliation: Service Commun des Laboratoires , 25 Avenue de la République, 91744 Massy, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Rétho
authors.affiliation: Service Commun des Laboratoires , 25 Avenue de la République, 91744 Massy, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Janvion
authors.affiliation: Service Commun des Laboratoires , 25 Avenue de la République, 91744 Massy, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Saltron
mesh_terms: D005591:Chemical Fractionation; D004852:Epoxy Compounds / Q000032:analysis* / Q000302:isolation & purification; D004952:Esters / Q000032:analysis* / Q000302:isolation & purification; D005506:Food Contamination / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D005990:Glycerol / Q000031:analogs & derivatives* / Q000032:analysis / Q000302:isolation & purification; D041943:Infant Formula / Q000737:chemistry*; D008872:Microwaves; D020005:Propanols / Q000032:analysis* / Q000302:isolation & purification; D000517:alpha-Chlorohydrin / Q000032:analysis* / Q000302:isolation & purification; D011409:Propylene Glycols
chemical_list: D004852:Epoxy Compounds; D004952:Esters; D005990:Glycerol; D020005:Propanols; D000517:alpha-Chlorohydrin; C585004:monochloropropanediol; D011409:Propylene Glycols; C004312:glycidol
keywords: 2-MCPD esters; 3-MCPD esters; GC−MS; foodstuffs; glycidyl esters; microwave extraction