title: Telocytes of the human adult trigeminal ganglion.
abstract: Telocytes (TCs) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in various organs, however little is known about their presence in human trigeminal ganglion. To address this issue, samples of trigeminal ganglia were tested by immunocytochemistry for CD34 and examined by transmission electron microscopy (TEM). We found that TCs are CD34 positive and form networks within the ganglion in close vicinity to microvessels and nerve fibers around the neuronal-glial units (NGUs). TEM examination confirmed the existence of spindle-shaped and bipolar TCs with one or two telopodes measuring between 15 to 53 μm. We propose that TCs are cells with stemness capacity which might contribute in regeneration and repair processes by: modulation of the stem cell activity or by acting as progenitors of other cells present in the normal tissue. In addition, further studies are needed to establish if they might influence the neuronal circuits.
authors.affiliation: Division of Anatomy, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.|International Society of Regenerative Medicine and Surgery (ISRMS), Bucharest, Romania.|MEDCENTER - Center of Excellence in Laboratory Medicine and Pathology, Bucharest, Romania.
authors.forename: Mugurel Constantin
authors.initials: MC
authors.lastname: Rusu
authors.affiliation: Division of Cellular and Molecular Biology and Histology, Department 2 Morphological Sciences, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.|Victor Babes National Institute of Pathology, Bucharest, Romania.
authors.forename: Dragos
authors.initials: D
authors.lastname: Cretoiu
authors.affiliation: Division of Anatomy, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Alexandra Diana
authors.initials: AD
authors.lastname: Vrapciu
authors.affiliation: Division of Legal Medicine and Bioethics, Department 2 Morphological Sciences, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Sorin
authors.initials: S
authors.lastname: Hostiuc
authors.affiliation: Division of Legal Medicine and Bioethics, Department 2 Morphological Sciences, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.|Department of Forensic Pathology, National Institute of Legal Medicine, Bucharest, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Dermengiu
authors.affiliation: Department of Cellular and Molecular Biology, National Institute of Research and Development for Biological Sciences, Bucharest, Romania.
authors.forename: Vasile Sorin
authors.initials: VS
authors.lastname: Manoiu
authors.affiliation: Division of Cellular and Molecular Biology and Histology, Department 2 Morphological Sciences, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. sanda@cretoiu.ro.|Victor Babes National Institute of Pathology, Bucharest, Romania. sanda@cretoiu.ro.
authors.forename: Sanda Maria
authors.initials: SM
authors.lastname: Cretoiu
authors.affiliation: Institute of Biology of Bucharest, The Romanian Academy, Bucharest, Romania. nick_mirancea@yahoo.com.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Mirancea
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis / Q000276:immunology; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D000067170:Telocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D000067617:Telopodes / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D012668:Trigeminal Ganglion / Q000166:cytology* / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D018952:Antigens, CD34
keywords: CD34; Extracellular vesicles; Telocytes; Telopodes; Trigeminal ganglion