title: Treatment of Mitochondrial Diabetes with a Peroxisome Proliferator-activated Receptor (PPAR)-gamma Agonist.
abstract: The 3243 A>G mutation in mitochondrial DNA is the most common cause of monogenic diabetes mellitus in Japan. A 45-year-old woman with mitochondrial diabetes and significant insulin resistance presented with hypoadiponectinemia despite a normal amount of visceral fat. Three months of treatment with pioglitazone (PIO) improved her blood glucose profile and response to the 75-g oral glucose tolerance test. These changes were accompanied by the amelioration of her insulin resistance and the impairment of early-phase insulin secretion. Her serum adiponectin levels increased to the normal range. In this case of mitochondrial diabetes, PIO was effective for glycemic control.
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan.
authors.forename: Hiroyo
authors.initials: H
authors.lastname: Ninomiya
authors.forename: Ayumu
authors.initials: A
authors.lastname: Hirata
authors.forename: Junji
authors.initials: J
authors.lastname: Kozawa
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nakata
authors.forename: Takekazu
authors.initials: T
authors.lastname: Kimura
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Kitamura
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Michio
authors.initials: M
authors.lastname: Otsuki
authors.forename: Akihisa
authors.initials: A
authors.lastname: Imagawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000172:deficiency; D001786:Blood Glucose / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008661:Metabolism, Inborn Errors / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D008928:Mitochondria / Q000187:drug effects; D047495:PPAR gamma / Q000819:agonists*; D010375:Pedigree; D000077205:Pioglitazone; D045162:Thiazolidinediones / Q000627:therapeutic use*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D004272:DNA, Mitochondrial; D007004:Hypoglycemic Agents; D007328:Insulin; D047495:PPAR gamma; D045162:Thiazolidinediones; D000077205:Pioglitazone