title: Role of FDG-PET scan in the management of pediatric mature B cell non-Hodgkin's lymphoma. CCHE experience.
abstract: OBJECTIVE
  To evaluate the sensitivity (Se), specificity (Sp), and predictive values (PV) of PET scan during management of pediatric mature B cell non-Hodgkin's lymphoma (NHL) in comparison with conventional computed tomography (CT) scan.
  
  
  METHODS
  A retrospective study enrolled on pediatric NHL patients at Children Cancer Hospital Egypt (CCHE) during the period from July 2007 to the end of June 2013.
  
  
  RESULTS
  For 115 pediatric patients diagnosed with mature B cell NHL, 152 PET and 152 CT scans were done simultaneously. Median age was 5.7years. They were 85 males (74%) and 30 females (26%). One hundred twenty six scans (82.9%) were done for 100 (87%) Burkitt lymphoma (BL) patients, while 26 scans (17.1%) were done for 15 (13.0%) patients with diffuse large B cell NHL (DLBC). Nineteen examination (12.5%) were done before starting chemotherapy (group 1), 107 (70.3%) at time of evaluation (group 2), and 26 (17.1%) during follow up (group C). Overall sensitivity was 91.6% for PET and 70.0% for conventional CT (p=0.02). Specificity was 84.1% for PET and 58.9% for CT (p<0.001). Positive predictive value (PPV) for PET was 50%, while was 22% for CT scan (p<0.001). Negative predictive value (NPV) for PET was 98%, and 92% for CT (p=0.01).
  
  
  CONCLUSIONS
  PET scan is significantly more sensitive than conventional CT in the management of aggressive pediatric mature B cell NHL. PET negativity is an excellent indicator of tumor response.
authors.affiliation: Department of Pediatric Oncology, National Cancer Institute and Children Cancer Hospital, Egypt. Electronic address: hanyrahman@hotmail.com.
authors.forename: Hany
authors.initials: H
authors.lastname: Abdel Rahman
authors.affiliation: Department of Pediatrics, National Research Centre and Children Cancer Hospital, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sedky
authors.affiliation: Department of Pediatric Oncology, National Cancer Institute and Children Cancer Hospital, Egypt.
authors.forename: Asmaa
authors.initials: A
authors.lastname: Hamoda
authors.affiliation: Department of Radiodiagnosis, National Cancer Institute and Children Cancer Hospital, Egypt.
authors.forename: Tarek
authors.initials: T
authors.lastname: Raafat
authors.affiliation: Department of Radiodiagnosis, National Cancer Institute and Children Cancer Hospital, Egypt.
authors.forename: Ayda
authors.initials: A
authors.lastname: Youssef
authors.affiliation: Department of Nuclear Medicine, National Cancer Institute and Children Cancer Hospital, Egypt.
authors.forename: Walid
authors.initials: W
authors.lastname: Omar
authors.affiliation: Department of Clinical Research, Children Cancer Hospital, Egypt.
authors.forename: Omneya
authors.initials: O
authors.lastname: Hassanein
authors.affiliation: Department of Medical Oncology, Menoufiah University and Children Cancer Hospital, Egypt.
authors.forename: Emad
authors.initials: E
authors.lastname: Moussa
mesh_terms: D000293:Adolescent; D002051:Burkitt Lymphoma / Q000000981:diagnostic imaging*; D002173:Cancer Care Facilities; D002648:Child; D002675:Child, Preschool; D004534:Egypt; D005260:Female; D019788:Fluorodeoxyglucose F18; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging*; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D011237:Predictive Value of Tests; D011859:Radiography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: CCHE; Mature B cell; PET scan; Pediatric NHL