title: Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones.
abstract: The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N'-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range.
authors.affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze Farmaceutiche, Farmacologiche e Nutraceutiche, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. vonnis@unica.it.
authors.forename: Valentina
authors.initials: V
authors.lastname: Onnis
authors.affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze Farmaceutiche, Farmacologiche e Nutraceutiche, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. monicademurtas@tiscali.it.
authors.forename: Monica
authors.initials: M
authors.lastname: Demurtas
authors.affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze Farmaceutiche, Farmacologiche e Nutraceutiche, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. deplano.a@gmail.com.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Deplano
authors.affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze Farmaceutiche, Farmacologiche e Nutraceutiche, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. gbalboni@unica.it.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Balboni
authors.affiliation: Dipartimento di Scienze della Vita e Biotecnologie, Università degli Studi di Ferrara, Via Fossato di Mortara 17-19, Ferrara I-44121, Italy. bldnna@unife.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Baldisserotto
authors.affiliation: Dipartimento di Scienze della Vita e Biotecnologie, Università degli Studi di Ferrara, Via Fossato di Mortara 17-19, Ferrara I-44121, Italy. mv9@unife.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Manfredini
authors.affiliation: Dipartmento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Ferrara, Via Fossato di Mortara 17-19, Ferrara I-44121, Italy. salvatore.pacifico@unife.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pacifico
authors.affiliation: KU Leuven-University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium. sandra.liekens@rega.kuleuven.be.
authors.forename: Sandra
authors.initials: S
authors.lastname: Liekens
authors.affiliation: KU Leuven-University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium. jan.balzarini@rega.kuleuven.be.
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D006835:Hydrazones
keywords: antiproliferative activity; benzimidazoles; hydrazones