title: Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine.
abstract: In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre-B cell colony-enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro-environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro-environment.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara, Italy.
authors.forename: Ambra A
authors.identifier: 0000-0003-0233-0700
authors.initials: AA
authors.lastname: Grolla
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara, Italy.
authors.forename: Cristina
authors.identifier: 0000-0002-9721-9572
authors.initials: C
authors.lastname: Travelli
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara, Italy.
authors.forename: Armando A
authors.identifier: 0000-0003-1923-7430
authors.initials: AA
authors.lastname: Genazzani
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara, Italy.
authors.forename: Jaswinder K
authors.identifier: 0000-0003-4157-0475
authors.initials: JK
authors.lastname: Sethi
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000378:metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase