title: Targeting dynamics of subclones of GI, liver and pancreatic cancers.
authors.affiliation: a Centre for Biosystems and Genomic Network Medicine , University of Ioannina , Ioannina , Greece.|b Department of Surgery , 'G. Hatzikosta' General Hospital , Ioannina , Greece.
authors.forename: Demosthenes E
authors.initials: DE
authors.lastname: Ziogas
authors.affiliation: c Department of Surgery , Ioannina University Hospital , Ioannina , Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Glantzounis
authors.affiliation: d 1st Department of Surgery , University of Athens School of Medicine, Laikon Hospital , Athens , Greece.
authors.forename: Theodore
authors.initials: T
authors.lastname: Liakakos
authors.affiliation: a Centre for Biosystems and Genomic Network Medicine , University of Ioannina , Ioannina , Greece.|c Department of Surgery , Ioannina University Hospital , Ioannina , Greece.|e Biomedical Research Foundation of the Academy of Athens (BRFAA) , Athens , Greece.
authors.forename: Dimitrios H
authors.initials: DH
authors.lastname: Roukos
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D020022:Genetic Predisposition to Disease; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D058990:Molecular Targeted Therapy; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018579:Patient Selection; D010641:Phenotype; D057285:Precision Medicine; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: Subclonal evolution and tumor heterogeneity; cancer genome; dynamics of genomic subclones; gastrointestinal cancers; next-generation sequencing; targeted drugs; therapeutic resistance