title: Effects of propolis in an experimental rat model of allergic rhinitis.
abstract: OBJECTIVE
  The aim of this study was to determine the anti-allergic activity of propolis in an ovalbumin-induced rat model of allergic rhinitis.
  
  
  METHODS
  This prospective experimental study was conducted at Hakan Çetinsaya Clinical and Experimental Animal Research Center with 30 rats. After sensitization of all rats with 0.3mg intraperitoneal ovalbumin plus 30mg aluminum hydroxide for 14days (first phase), rats were divided to five groups. In the second phase of the study 10μL of ovalbumin was applied to each nostril for 21days. Together with second phase, ketotifen (n:6), oral propolis (n:6), intranasal propolis (n:6) and intranasal mometasone furoate (n:6) were given to rats. A control group (n:4)(salin) and sham group (n:2) were planned. Symptoms were assessed on days 19, 22, 25, 30 and 35, resulting in 5 symptom scores: symptom scores 1-5. On day 35, nasal tissue was removed and histological examination was performed.
  
  
  RESULTS
  When rats that received systemic and intranasal propolis were compared to controls, ciliary loss, inflammation, increase in goblet cells, vascular proliferation, eosinophil count, chondrocytes and allergic rhinitis symptom score were found to be decreased (p<0.05).
  
  
  CONCLUSIONS
  It was found that propolis had anti-allergic effects on allergic symptom scores and nasal histology.
authors.affiliation: Kayseri Training and Research Hospital, Department of ENT. Electronic address: drmyasar@hotmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yasar
authors.affiliation: Kayseri Training and Research Hospital, Department of Histology.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Savranlar
authors.affiliation: Kayseri Training and Research Hospital, Department of Pathology.
authors.forename: Hatice
authors.initials: H
authors.lastname: Karaman
authors.affiliation: Kayseri Training and Research Hospital, Department of ENT.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sagit
authors.affiliation: Erciyes University Faculty of Agriculture, Department of Agricultural Biotechnology Agriculture Research Unit.
authors.forename: Sibel
authors.initials: S
authors.lastname: Silici
authors.affiliation: Kayseri Training and Research Hospital, Department of ENT.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozcan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D010047:Ovalbumin; D011429:Propolis / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D065631:Rhinitis, Allergic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D010047:Ovalbumin; D011429:Propolis