title: Osteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives.
abstract: Specific soluble biomarkers can be powerful tools for the diagnosis, prognosis and personalized management of osteoarthritis (OA). Biomarkers are potential indicators of the effect of a drug on cartilage metabolism and provide crucial information about the mechanisms of drug action. In this review, we address key questions concerning the use of biomarkers in OA management: Why do we need soluble biomarkers? What are the most widely investigated biomarkers derived from cartilage extracellular matrix? What are the most common pitfalls in interpreting soluble biomarker measurements? What are the perspectives and future research directions in this field? We review current evidence to propose that cartilage-derived soluble biomarkers are complementary "drug development tools" that can be applied during drug development from preclinical research to clinical evaluation. In the future, such biomarkers could be surrogate markers of clinical and/or imaging outcomes. Successful standardization and implementation of automated biomarker assays will facilitate their use in companion diagnostics in the context of personalized medicine for enhanced management of OA.
authors.affiliation: Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium; Artialis SA, GIGA Tower, CHU Sart-Tilman, 4000 Liège, Belgium; Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium. Electronic address: yhenrotin@ulg.ac.be.
authors.forename: Y
authors.initials: Y
authors.lastname: Henrotin
authors.affiliation: Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Sanchez
authors.affiliation: Rheumatology, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.
authors.forename: A C
authors.initials: AC
authors.lastname: Bay-Jensen
authors.affiliation: Faculty of Health and Medical Sciences, University of Surrey, Surrey, GU2 7XH United Kingdom; Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Arthritis Research UK Pain Centre, Medical Research Council and Arthritis Research UK Centre for Musculoskeletal Ageing Research, Queen's Medical Centre, Nottingham, NG7 2UH United Kingdom; Center of Excellence in Genomic Medicine Research (CEGMR), King Fahd Medical Research Center (KFMRC), Faculty of Applied Medical Sciences, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.
authors.forename: A
authors.initials: A
authors.lastname: Mobasheri
mesh_terms: D015415:Biomarkers / Q000032:analysis; D002358:Cartilage, Articular / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Cartilage; Extracellular matrix; Osteoarthritis