title: Chronic Peripheral Inflammation is Associated With Cognitive Impairment in Schizophrenia: Results From the Multicentric FACE-SZ Dataset.
abstract: Inflammation, measured by abnormal blood C-reactive protein (CRP) level, has been described in schizophrenia (SZ), being inconsistently related to impaired cognitive functions. The aim of the present study is to investigate cognitive impairment associated with abnormal CRP levels in a large multi-centric sample of community-dwelling SZ patients, using a comprehensive neuropsychological battery.
  
  
  
  Three hundred sixty-nine community-dwelling stable SZ subjects (76.2% men, mean age 32.7 y) were included and tested with a comprehensive battery of neuropsychological tests. Abnormal CRP level was defined as >3mg/L.
  
  
  
  Multiple factor analysis revealed that abnormal CRP levels, found in 104 patients (28.2%), were associated with impaired General Intellectual Ability and Abstract Reasoning (aOR = 0.56, 95% CI 0.35-0.90, P = .014), independently of age, sex, education level, psychotic symptomatology, treatments, and addiction comorbidities. Abnormal CRP levels were also associated with the decline of all components of working memory (respectively effect size [ES] = 0.25, P = .033; ES = 0.27, P = .04; ES = 0.33, P = .006; and ES = 0.38, P = .004) and a wide range of other impaired cognitive functions, including memory (ES = 0.26, P = .026), learning abilities (ES = 0.28, P = .035), semantic memory (ES = 0.26, P = .026), mental flexibility (ES = 0.26, P = .044), visual attention (ES = 0.23, P = .004) and speed of processing (ES = 0.23, P = .043).
  
  
  
  Our results suggest that abnormal CRP level is associated with cognitive impairment in SZ. Evaluating the effectiveness of neuroprotective anti-inflammatory strategies is needed in order to prevent cognitive impairment in SZ.
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955, Translational Psychiatry Team, Créteil, France, Paris Est University, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France;
authors.forename: Ewa
authors.initials: E
authors.lastname: Bulzacka
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Pôle psychiatrie universitaire, CHU Sainte-Marguerite, F-13274 Marseille cedex 09, France;
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France;
authors.forename: Franck
authors.initials: F
authors.lastname: Schürhoff
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France, INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France;
authors.forename: Ophélia
authors.initials: O
authors.lastname: Godin
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France;
authors.forename: Fabrice
authors.initials: F
authors.lastname: Berna
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955, Translational Psychiatry Team, Créteil, France, Paris Est University, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France;
authors.forename: Lore
authors.initials: L
authors.lastname: Brunel
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955, Translational Psychiatry Team, Créteil, France, Paris Est University, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France;
authors.forename: Méja
authors.initials: M
authors.lastname: Andrianarisoa
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Centre Hospitalier Charles Perrens, Université de Bordeaux, F-33076 Bordeaux, France; Inserm, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France;
authors.forename: Bruno
authors.initials: B
authors.lastname: Aouizerate
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France;
authors.forename: Delphine
authors.initials: D
authors.lastname: Capdevielle
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France;
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chéreau-Boudet
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier Pole Est BP 300 39- 95 bd Pinel-69678 BRON Cedex, France;
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Chesnoy-Servanin
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France;
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Danion
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France;
authors.forename: Caroline
authors.initials: C
authors.lastname: Dubertret
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble, France;
authors.forename: Julien
authors.initials: J
authors.lastname: Dubreucq
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Assistance Publique des Hôpitaux de Marseille (AP-HM), pôle universitaire de psychiatrie, Marseille, France;
authors.forename: Catherine
authors.initials: C
authors.lastname: Faget
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble, France;
authors.forename: Franck
authors.initials: F
authors.lastname: Gabayet
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955, Translational Psychiatry Team, Créteil, France, Paris Est University, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France;
authors.forename: Tifenn
authors.initials: T
authors.lastname: Le Gloahec
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France;
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France;
authors.forename: Jasmina
authors.initials: J
authors.lastname: Mallet
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Centre Hospitalier Charles Perrens, Université de Bordeaux, F-33076 Bordeaux, France; CNRS UMR 5287 - Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Bordeaux, France;
authors.forename: David
authors.initials: D
authors.lastname: Misdrahi
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier Pole Est BP 300 39- 95 bd Pinel-69678 BRON Cedex, France;
authors.forename: Romain
authors.initials: R
authors.lastname: Rey
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Assistance Publique des Hôpitaux de Marseille (AP-HM), pôle universitaire de psychiatrie, Marseille, France;
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Service de psychiatrie d'adulte, Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Passerieux
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Service de psychiatrie d'adulte, Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Roux
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France;
authors.forename: Hanan
authors.initials: H
authors.lastname: Yazbek
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955, Translational Psychiatry Team, Créteil, France, Paris Est University, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France;
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.affiliation: Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955, Translational Psychiatry Team, Créteil, France, Paris Est University, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France; guillaume.fond@gmail.com.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Fond
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D002908:Chronic Disease; D060825:Cognitive Dysfunction / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood* / Q000150:complications
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein (CRP); cognition; cognitive impairment; inflammation; schizophrenia