title: Neuro-Immune Interactions at Barrier Surfaces.
abstract: Multidirectional interactions between the nervous and immune systems have been documented in homeostasis and pathologies ranging from multiple sclerosis to autism, and from leukemia to acute and chronic inflammation. Recent studies have addressed this crosstalk using cell-specific targeting, novel sequencing, imaging, and analytical tools, shedding light on unappreciated mechanisms of neuro-immune regulation. This Review focuses on neuro-immune interactions at barrier surfaces-mostly the gut, but also including the skin and the airways, areas densely populated by neurons and immune cells that constantly sense and adapt to tissue-specific environmental challenges.
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, Edifício Egas Moniz, 1649-028 Lisboa, Portugal. Electronic address: jhfernandes@medicina.ulisboa.pt.
authors.forename: Henrique
authors.initials: H
authors.lastname: Veiga-Fernandes
authors.affiliation: Laboratory of Mucosal Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: mucida@rockefeller.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Mucida
mesh_terms: D000818:Animals; D006410:Hematopoiesis; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology / Q000294:innervation; D007422:Intestines / Q000276:immunology / Q000294:innervation; D008221:Lymphoid Tissue / Q000276:immunology / Q000502:physiology; D009092:Mucous Membrane / Q000276:immunology* / Q000294:innervation*; D009420:Nervous System / Q000033:anatomy & histology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology