title: Chemokines and their receptors in lung cancer progression and metastasis.
abstract: Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is still high and the 5-year survival is a dismal 15%. Fortunately, early detection by low-dose computed tomography (LDCT) scans has reduced mortality by 20%; yet, overall, 5-year-survival remains low at less than 20%. Therefore, in order to ameliorate this situation, a thorough understanding of the underlying molecular mechanisms is urgently needed. Chemokines and their receptors, crucial microenvironmental factors, play important roles in lung tumor genesis, progression, and metastasis, and exploring the mechanisms of this might bring new insights into early diagnosis and precisely targeted treatment. Consequently, this review will mainly focus on recent advancements on the axes of chemokines and their receptors of lung cancer.
authors.affiliation: Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.|Department of Radiology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China.
authors.forename: Zeng-Hui
authors.initials: ZH
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Shi
authors.affiliation: Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xiong
authors.affiliation: Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D054415:Chemokine CCL19 / Q000502:physiology; D018932:Chemokine CCL2 / Q000502:physiology; D054407:Chemokine CCL4 / Q000502:physiology; D054360:Chemokine CXCL1 / Q000502:physiology; D054377:Chemokine CXCL12 / Q000502:physiology; D018925:Chemokines / Q000502:physiology*; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008024:Ligands; D008175:Lung Neoplasms / Q000473:pathology*; D009362:Neoplasm Metastasis; D019718:Receptors, CXCR4 / Q000502:physiology
chemical_list: C515460:CCL19 protein, human; C111835:CCL2 protein, human; C066507:CCL4 protein, human; C475829:CXCL1 protein, human; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054415:Chemokine CCL19; D018932:Chemokine CCL2; D054407:Chemokine CCL4; D054360:Chemokine CXCL1; D054377:Chemokine CXCL12; D018925:Chemokines; D008024:Ligands; D019718:Receptors, CXCR4
keywords: Chemokines; Lung cancer; Metastasis; Tumor progression