title: IDH1-Driven Reductive Carboxylation Supports Anchorage Independence.
abstract: Adaptation to anchorage-independent growth requires IDH1-mediated changes in citrate metabolism.
mesh_terms: D000222:Adaptation, Physiological; D049109:Cell Proliferation; D002951:Citrates / Q000378:metabolism; D002952:Citric Acid Cycle; D005109:Extracellular Matrix; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption
chemical_list: D002951:Citrates; D007521:Isocitrate Dehydrogenase