title: Liver Shear-Wave Velocity and Serum Fibrosis Markers to Diagnose Hepatic Fibrosis in Patients with Chronic Viral Hepatitis B.
abstract: To compare several noninvasive indices of fibrosis in chronic viral hepatitis B, including liver shear-wave velocity (SWV), hyaluronic acid (HA), collagen type IV (CIV), procollagen type III (PCIII), and laminin (LN).
  
  
  
  Acoustic radiation force impulse (ARFI) was performed in 157 patients with chronic viral hepatitis B and in 30 healthy volunteers to measure hepatic SWV (m/s) in a prospective study. Serum markers were acquired on the morning of the same day of the ARFI evaluation. Receiver operating characteristic (ROC) analysis was performed to evaluate and compare the accuracies of SWV and serum markers using METAVIR scoring from liver biopsy as a reference standard.
  
  
  
  The most accurate test for diagnosing fibrosis F ≥ 1 was SWV with the area under the ROC curve (AUC) of 0.913, followed by LN (0.744), HA (0.701), CIV (0.690), and PCIII (0.524). The best test for diagnosing F ≥ 2 was SWV (AUC of 0.851), followed by CIV (0.671), HA (0.668), LN (0.562), and PCIII (0.550). The best test for diagnosing F ≥ 3 was SWV (0.854), followed by CIV (0.693), HA (0.675), PCIII (0.591), and LN (0.548). The best test for diagnosing F = 4 was SWV (0.965), followed by CIV (0.804), PCIII (0.752), HA (0.744), and LN (0.662). SWV combined with HA and CIV did not improve diagnostic accuracy (AUC = 0.931 for F ≥ 1, 0.863 for F ≥ 2, 0.855 for F ≥ 3, 0.960 for F = 4).
  
  
  
  The performance of SWV in diagnosing liver fibrosis is superior to that of serum markers. However, the combination of SWV, HA, and CIV does not increase the accuracy of diagnosing liver fibrosis and cirrhosis.
authors.affiliation: Department of Ultrasonography, Baoji Central Hospital, Baoji, Shaanxi 721008, China.; Department of Ultrasonography, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Jianxue
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Ultrasonography, Baoji Central Hospital, Baoji, Shaanxi 721008, China.
authors.forename: Yonghao
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of Ultrasonography, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ai
authors.affiliation: Department of Infectious Disease, Baoji Central Hospital, Baoji, Shaanxi 721008, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ning
authors.affiliation: Department of Ultrasonography, Baoji Central Hospital, Baoji, Shaanxi 721008, China.
authors.forename: Junzhi
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Ultrasonography, Baoji Central Hospital, Baoji, Shaanxi 721008, China.
authors.forename: Yaoren
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ultrasonography, Baoji Central Hospital, Baoji, Shaanxi 721008, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Dun
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D024061:Collagen Type III / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D054459:Elasticity Imaging Techniques; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology*; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D012372:ROC Curve; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D024061:Collagen Type III; D024141:Collagen Type IV; D007797:Laminin; D006820:Hyaluronic Acid
keywords: ARFI imaging; Chronic hepatitis B; Liver fibrosis; Serum markers