title: Initiation or maintenance of beta-blocker therapy in patients hospitalized for acute heart failure.
abstract: Background Beta-blockers have been recommended for patients with heart failure and reduced ejection fraction for their long-term benefits. However, the tolerance to betablockers in patients hospitalized with acute heart failure should be evaluated. Objective To estimate the proportion of patients hospitalized with acute heart failure who can tolerate these agents in clinical practice and compare the clinical outcomes of patients who can and cannot tolerate treatment with beta-blockers. Setting Two reference hospitals in cardiology. Methods Retrospective cohort study of consecutive patients hospitalized for acute heart failure between September 2008 and May 2012. Population-based sample. During the study period, 325 patients were admitted consecutively, including 194 individuals with an acute heart failure diagnosis and systolic left ventricular dysfunction and ejection fraction ≤45 %, who were candidates for the initiation or continuation of beta-blockers. Main outcome measure The percentage of patients intolerant to beta-blockers and the clinical characteristics of patients. Results On admission, 61.8 % of patients were already using beta-blockers, and 73.2 % were using beta-blockers on discharge. During hospitalization, 85 % of patients used these agents for some period. The main reasons for not using betablockers were low cardiac output syndrome (24.4 %), bradycardia (24.4 %), severe hypotension or shock (17.8 %), and chronic obstructive pulmonary disease (13.3 %). Patients who were intolerant or did not use a beta-blocker had a longer hospital stay (18.3 vs. 11.0 days; p < .001), greater use of vasoactive drugs (41.5 vs. 16.3 %; p < .001, CI 1.80-7.35), sepsis and septic shock (RR = 3.02; CI 95 % 1.59-5.75), and higher mortality rate during hospitalization (22.6 vs. 2.9 %; p < .001; CI 3.05-32.26). Conclusion Beta-blockers could be used in 73.2 % of patients hospitalized for acute heart failure. Patients who can not tolerate BB presented a higher frequency of adverse clinical outcomes including frequency of sepsis, use of vasoactive drugs, average length of hospitalization, and death.
authors.affiliation: Post Graduate Program in Medicine and Health, Federal University of Bahia, Rua Augusto Viana SN, Canela, Salvador, Bahia, 40110-160, Brazil. lcpassos@ufba.br.
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Passos
authors.affiliation: Anísio Teixeira Campus, Multidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, Brazil.
authors.forename: Márcio Galvão
authors.initials: MG
authors.lastname: Oliveira
authors.affiliation: Ana Nery Hospital, Salvador, Brazil.
authors.forename: Andre Rodrigues
authors.initials: AR
authors.lastname: Duraes
authors.affiliation: Post Graduate Program in Medicine and Health, Federal University of Bahia, Rua Augusto Viana SN, Canela, Salvador, Bahia, 40110-160, Brazil.
authors.forename: Thiago Moreira
authors.initials: TM
authors.lastname: Trindade
authors.affiliation: Cardiology Bahia Foundation, Salvador, Brazil.
authors.forename: Andréa Cristina Costa
authors.initials: AC
authors.lastname: Barbosa
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: Acute heart failure; Beta-blockers; Brazil