title: Neuroendocrine tumors of the small bowel: evaluation with MR-enterography.
abstract: OBJECTIVE
  To determine the sensitivity of magnetic resonance (MR)-enterography for the detection of neuroendocrine tumors of the small-bowel (NETSB) and analyze the imaging presentation of NETSB on MR-enterography.
  
  
  METHODS
  The MR-enterography studies (including HASTE, TruFISP, and 3D VIBE MR sequences before and after intravenous administration of a gadolinium-chelate) of 19 patients with pathologically confirmed NETSB were blindly reviewed. Images were analyzed with respect to imaging presentation. Sensitivity of MR-enterography as well as that of each individual MR-enterography sequence for the diagnosis of NETSB was estimated with 95% confidence intervals (CIs). Comparisons between individual MR-enterography sequences were performed using the McNemar test.
  
  
  RESULTS
  Twenty-seven NETSBs were confirmed in 19 patients. Overall sensitivity of MR-enterography for NETSB detection was 74% (20/27; 95% CI: 54-89%) on a per-lesion basis. On a per-patient basis, MR-enterography had a sensitivity of 95% (18/19; 95% CI: 74-100%) for the detection of NETSB. Best degrees of sensitivity were achieved with 3D VIBE MR-enterography sequences after intravenous administration of a gadolinium-chelate (Se=95%; 18/19) by comparison with HASTE (Se=26%; 5/19) and TruFISP (Se=26%; 5/19) sequences (P=.00022). Visible focal small-bowel mass, mesenteric stranding, and mesenteric mass were found in 16/19 (84%), 17/19 (89%), and 15/19 (79%) patients, respectively.
  
  
  CONCLUSIONS
  MR-enterography shows highly suggestive features for the diagnosis of NETSB and has high degrees of sensitivity for the diagnosis of NETSB on a per-patient basis.
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France; Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France; UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France. Electronic address: anthony.dohan@lrb.aphp.fr.
authors.forename: Anthony
authors.initials: A
authors.lastname: Dohan
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: hassangreenmed@gmail.com.
authors.forename: Hassan
authors.initials: H
authors.lastname: El Fattach
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: maxime.barat89@gmail.com.
authors.forename: Maxime
authors.initials: M
authors.lastname: Barat
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: youcef.guerrache@aphp.fr.
authors.forename: Youcef
authors.initials: Y
authors.lastname: Guerrache
authors.affiliation: Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France; UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France; Department of Digestive Surgery, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris cedex 10, France. Electronic address: clarisse.eveno@lrb.aphp.fr.
authors.forename: Clarisse
authors.initials: C
authors.lastname: Eveno
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France; Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France. Electronic address: raphael.dautry@aphp.fr.
authors.forename: Raphael
authors.initials: R
authors.lastname: Dautry
authors.affiliation: Department of Radiology, Hôpital Robert Debré, 11 Boulevard Pasteur, 51092 Reims Cedex, France. Electronic address: sebastien.mule@gmail.com.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Mulé
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: mourad.boudiaf@lrb.aphp.fr.
authors.forename: Mourad
authors.initials: M
authors.lastname: Boudiaf
authors.affiliation: Department of Radiology, Hôpital Robert Debré, 11 Boulevard Pasteur, 51092 Reims Cedex, France. Electronic address: choeffel-fornes@chu-reims.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Hoeffel
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France; Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France; UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France. Electronic address: philippe.soyer@lrb.aphp.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Soyer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000000981:diagnostic imaging*; D007580:Jejunal Neoplasms / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media
keywords: Intestinal neoplasm; MR-enterography; Neuroendocrine tumor; Small bowel; Small bowel tumor detection