title: Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma).
abstract: OBJECTIVE
  Primary mediastinal large B-cell lymphomas (PMLBCLs) are aggressive lymphomas with characteristic clinical, morphologic, and immunophenotypic features. "Double-hit" (DH) lymphomas are B-cell neoplasms characterized by a translocation involving MYC and either BCL2 or BCL6 In the indexed literature, there are no reported cases of PMLBCL associated with DH or triple-hit events.
  
  
  METHODS
  Herein, we present a case of a 15-year-old girl with PMLBCL who had typical clinical, morphologic, and immunophenotypic features.
  
  
  RESULTS
  Fluorescent in situ hybridization studies showed rearrangements involving MYC and BCL6 We also excluded the possibility of a reciprocal t(3;8) (3q27;8q24) BCL6/MYC translocation.
  
  
  CONCLUSIONS
  This case expands the current spectrum of lymphomas subtypes in which DH can be found and supports the rationale for cytogenetic testing for DH abnormalities in all cases of aggressive large B-cell lymphomas regardless of subtype.
authors.affiliation: From the Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Jackson Memorial Hospital, Miami, FL.
authors.forename: Germán
authors.initials: G
authors.lastname: Campuzano-Zuluaga
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ortiz
authors.affiliation: Cytogenetics and Molecular Diagnostic Laboratory, Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL.
authors.forename: Jing-Hong
authors.initials: JH
authors.lastname: Peng
authors.affiliation: From the Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Jackson Memorial Hospital, Miami, FL.
authors.forename: Offiong
authors.initials: O
authors.lastname: Francis Ikpatt
authors.affiliation: Cytogenetics and Molecular Diagnostic Laboratory, Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL.
authors.forename: Yao-Shan
authors.initials: YS
authors.lastname: Fan
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL.
authors.forename: Julio C
authors.initials: JC
authors.lastname: Barredo
authors.affiliation: From the Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Jackson Memorial Hospital, Miami, FL.
authors.forename: Francisco
authors.initials: F
authors.lastname: Vega
authors.affiliation: From the Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Jackson Memorial Hospital, Miami, FL jchapman@med.miami.edu.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Chapman
mesh_terms: D000293:Adolescent; D005260:Female; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology; D008479:Mediastinal Neoplasms / Q000235:genetics* / Q000473:pathology; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C084103:BCL6 protein, human; C489427:MYC protein, human; D051560:Proto-Oncogene Proteins c-bcl-6; D016271:Proto-Oncogene Proteins c-myc
keywords: BCL6; Double hit; Large B-cell lymphoma; MYC; Primary mediastinal large B-cell lymphoma