title: Noncanonical connections between the subiculum and hippocampal CA1.
abstract: The hippocampal formation is traditionally viewed as having a feedforward, unidirectional circuit organization that promotes propagation of excitatory processes. While the substantial forward projection from hippocampal CA1 to the subiculum has been very well established, accumulating evidence supports the existence of a significant backprojection pathway comprised of both excitatory and inhibitory elements from the subiculum to CA1. Based on these recently updated anatomical connections, such a backprojection could serve to modulate information processing in hippocampal CA1. Here we review the published anatomical and physiological studies on the subiculum to CA1 backprojection, and present recent conclusive anatomical evidence for the presence of noncanonical subicular projections to CA1. New insights into this understudied pathway will improve our understanding of reciprocal CA1-subicular connections and guide future studies on how the subiculum interacts with CA1 to regulate hippocampal circuit activity and learning and memory behaviors. J. Comp. Neurol. 524:3666-3673, 2016. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
authors.affiliation: Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, California, USA. xiangmin.xu@uci.edu.|Department of Biomedical Engineering, University of California, Irvine, California, USA. xiangmin.xu@uci.edu.|Department of Microbiology and Molecular Genetics, University of California, Irvine, California, USA. xiangmin.xu@uci.edu.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, California, USA.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California, USA.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Holmes
authors.affiliation: Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, California, USA.
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: López
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000033:anatomy & histology* / Q000502:physiology*; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology*; D008959:Models, Neurological; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D056347:Neuroanatomical Tract-Tracing Techniques
keywords: back projection; genetic targeting; hippocampus; learning and memory; viral tracing