title: Two new ursane-type triterpenoid saponins from Elsholtzia bodinieri.
abstract: Two new ursane-type triterpenoid saponins, bodiniosides M (1) and N (2), along with three known saponins, oblonganosides I (3), pseudobuxussaponin B (4) and bodinioside A (5), were isolated from the aerial parts of Elsholtzia bodinieri. The structures of compounds 1 and 2 were characterized by spectroscopic data as well as acid hydrolysis and GC analysis as 3-O-β-D-xylopyranosyl-19α-hydroxy-23-acetoxy-urs-12(13)-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1-2)-β-D-glucopyranoside and 3-O-β-D-glucopyranosyl-2α,19α-dihydroxy-urs-12(13)-en-28,20β-lactone. Compounds 1 and 5 exhibited potent anti-HCV activities in vitro with a selective index of 6.53 and 4.41, respectively.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
authors.forename: Jin-Dong
authors.initials: JD
authors.lastname: Zhong
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Zhao
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Li
authors.affiliation: Duke University Medical Center, Duke University, Durham, NC, USA.
authors.forename: Chin-Ho
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
authors.forename: Xue-Shan
authors.initials: XS
authors.lastname: Xia
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China. rongtaolikm@163.com.
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D055808:Drug Discovery / Q000379:methods*; D016174:Hepacivirus / Q000187:drug effects; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D053978:Pentacyclic Triterpenes
chemical_list: D000998:Antiviral Agents; D012503:Saponins; D014315:Triterpenes; C000606873:ursane; D053978:Pentacyclic Triterpenes
keywords: Anti-HCV activities; Elsholtzia bodinieri; Labiatae; Saponins; Ursane-type triterpenoid