title: Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats.
abstract: Fetal growth restriction (FGR) and coagulopathies are often associated with aberrant maternal inflammation. Moderate-intensity exercise during pregnancy has been shown to increase utero-placental blood flow and to enhance fetal nutrition as well as fetal and placental growth. Furthermore, exercise is known to reduce inflammation. To evaluate the effect of moderate-intensity exercise on inflammation associated with the development of maternal coagulopathies and FGR, Wistar rats were subjected to an exercise regime before and during pregnancy. To model inflammation-induced FGR, pregnant rats were administered daily intraperitoneal injections of E. coli lipopolysaccharide (LPS) on gestational days (GD) 13.5-16.5 and sacrificed at GD 17.5. Control rats were injected with saline. Maternal hemostasis was assessed by thromboelastography. Moderate-intensity exercise prevented LPS-mediated increases in white blood cell counts measured on GD 17.5 and improved maternal hemostasis profiles. Importantly, our data reveal that exercise prevented LPS-induced FGR. Moderate-intensity exercise initiated before and maintained during pregnancy may decrease the severity of maternal and perinatal complications associated with abnormal maternal inflammation.
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.|Department of Obstetrics and Gynaecology, University of Campinas, Campinas, SP, Brazil.
authors.forename: Karina T
authors.initials: KT
authors.lastname: Kasawara
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cotechini
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
authors.forename: Shannyn K
authors.initials: SK
authors.lastname: Macdonald-Goodfellow
authors.affiliation: Department of Obstetrics and Gynaecology, University of Campinas, Campinas, SP, Brazil.
authors.forename: Fernanda G
authors.initials: FG
authors.lastname: Surita
authors.affiliation: Department of Obstetrics and Gynaecology, University of Campinas, Campinas, SP, Brazil.
authors.forename: João L
authors.initials: JL
authors.lastname: Pinto E Silva
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
authors.forename: Chandrakant
authors.initials: C
authors.lastname: Tayade
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
authors.forename: Maha
authors.initials: M
authors.lastname: Othman
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
authors.forename: Terence R S
authors.initials: TR
authors.lastname: Ozolinš
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Graham
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D005333:Fetus; D005865:Gestational Age; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy; D007958:Leukocyte Count; D008070:Lipopolysaccharides / Q000494:pharmacology; D010805:Physical Conditioning, Animal; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013916:Thrombelastography
chemical_list: D008070:Lipopolysaccharides