title: Gene expression in a rarely studied intraabdominal adipose depot, the round ligament, in severely obese women: A pilot study.
abstract: Gene expression (qPCR) was compared in round ligament (RL), omental (OME) and mesenteric (MES) ATs from 48 severely obese women (BMI, 54±11 kg/m(2); 38±9 yrs). The mRNA levels of enzymes of lipid metabolism (LPL, HSL, and PDE-3B), cortisol production (11βHSD-1), adipogenesis (PPAR-γ1/2), thrombosis and inflammation (PAI-1, IL-6, TNF-α and adiponectin) were determined. AT-LPL mRNA was highest in RL. The highest PDE-3B and lowest PAI-1 mRNA levels were observed in RL and MES. The lowest IL-6 and TNF-α and the highest adiponectin and PPAR-g1/2 mRNA levels were found in RL AT. 11βHSD-1 was highest in RL and OME. A higher lipogenic and adipogenic, and lower pro-inflammatory and pro-thrombotic profiles of the RL suggest a lesser deleterious impact on obesity-related complications.
authors.affiliation: Department of Kinesiology, Faculty of Medicine, Laval University, Québec, Canada; Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Mauriège
authors.affiliation: Department of Kinesiology, Faculty of Medicine, Laval University, Québec, Canada; Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Canada.
authors.forename: D R
authors.initials: DR
authors.lastname: Joanisse
authors.affiliation: Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval , Québec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Cartier
authors.affiliation: Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval , Québec, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Lemieux
authors.affiliation: Axe Endocrinologie et Néphrologie, Center de Recherche du Center Hospitalier Universitaire de Québec, Université Laval , Québec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Bergeron
authors.affiliation: Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Canada; Department of Surgery, Faculty of Medicine, Laval University, Québec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Biron
authors.affiliation: Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Canada; Department of Surgery, Faculty of Medicine, Laval University, Québec, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Marceau
authors.affiliation: Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Canada; Department of Physiology, Faculty of Medicine, Laval University, Québec, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Richard
keywords: lipid metabolism; regional variation; secretory function; severe obesity