title: How autophagy both activates and inhibits cellular senescence.
abstract: Autophagy and cellular senescence are stress responses essential for homeostasis. While recent studies indicate a genetic relationship between autophagy and senescence, whether autophagy acts positively or negatively on senescence is still subject to debate. Although autophagy was originally recognized as a nonspecific lysosomal degradation pathway (general autophagy), increasing evidence supports a selective form of autophagy that mediates the degradation of specific targets (selective autophagy). Our recent study revealed distinctive roles of selective autophagy and general autophagy in the regulation of senescence, at least in part resolving apparently contradictory reports regarding the relationship between these 2 important homeostatic stress responses.
authors.affiliation: a Department of Genetics , Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute , Boston , MA , USA.
authors.forename: Chanhee
authors.initials: C
authors.lastname: Kang
authors.affiliation: a Department of Genetics , Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute , Boston , MA , USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Elledge
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D004249:DNA Damage / Q000235:genetics*; D050991:GATA4 Transcription Factor / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D010641:Phenotype
chemical_list: D050991:GATA4 Transcription Factor; C484170:GATA4 protein, human
keywords: Cellular senescence; DNA damage response (DDR); GATA4; SQSTM1/p62; selective autophagy; senescence-associated secretory phenotype (SASP)