title: [Anti-Inflammatory Activity of the Polypeptide of the Sea Anemone, Heteractis crispa].
abstract: The anti-inflammatory effect of the recombinant polypeptide HCGS 1.20, a Kunitz-type serine protease inhibitor of the sea anemone Heteractis crispa, was investigated. It was shown that the polypeptide inhibits the increase of the concentration of calcium ions in mouse bone marrow derived macrophages elicited by histamine, and reduces the content of NO in lipopolysaccharide stimulated macrophages. A presumable mechanism of anti-inflammatory action of the polypeptide was being discussed.
authors.forename: O V
authors.initials: OV
authors.lastname: Sintsova
authors.forename: M M
authors.initials: MM
authors.lastname: Monastyrnaya
authors.forename: E A
authors.initials: EA
authors.lastname: Pislyagin
authors.forename: E S
authors.initials: ES
authors.lastname: Menchinskaya
authors.forename: E V
authors.initials: EV
authors.lastname: Leychenko
authors.forename: D L
authors.initials: DL
authors.lastname: Aminin
authors.forename: E P
authors.initials: EP
authors.lastname: Kozlovskaya
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006632:Histamine / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology; D012615:Sea Anemones / Q000737:chemistry / Q000235:genetics
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010455:Peptides; D009569:Nitric Oxide; D006632:Histamine