title: Non-cholesterol Sterols in the Diagnosis and Treatment of Dyslipidemias: A Review.
abstract: Non-cholesterol sterols have been used as markers of cholesterol intestinal absorption and hepatic synthesis, leading to a better understanding of cholesterol homeostasis in humans. This review discusses the main noncholesterol sterols that are clinically useful, different methods to quantify the factors associated with blood concentration, and the potential role of non-cholesterol sterols in the diagnosis and treatment of different types of dyslipidemia. The main indication is the use of non-cholesterol sterols for the diagnosis of rare diseases associated with defects in cholesterol synthesis or anomalies in the absorption and/or elimination of phytosterols. However, other potential uses, including the diagnosis of certain hypercholesterolemias and the individualization of lipid-lowering therapies, are promising as they could help treat a wider population.
authors.affiliation: Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Paseo Isabel La Católica 1-3, 50009, Zaragoza, Spain;. ubailarueda@gmail.com.
authors.forename: Lucía
authors.initials: L
authors.lastname: Baila-Rueda
authors.forename: Ana
authors.initials: A
authors.lastname: Cenarro
authors.forename: Fernando
authors.initials: F
authors.lastname: Civeira
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D050171:Dyslipidemias / Q000175:diagnosis* / Q000188:drug therapy*; D000069438:Ezetimibe / Q000627:therapeutic use; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D000072376:Oxysterols / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D010840:Phytosterols / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D017035:Pravastatin / Q000627:therapeutic use; D013261:Sterols / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D001647:Bile Acids and Salts; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C410800:NPC1L1 protein, human; D000072376:Oxysterols; D010840:Phytosterols; D013261:Sterols; D002784:Cholesterol; D000069438:Ezetimibe; D017035:Pravastatin