title: Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report.
abstract: Calcitriol-mediated hypercalcemia is a frequent manifestation of hematological malignancies. However, there are a few reports of cases presenting with increased angiotensin-converting enzyme (ACE) level, which suggests a possible mechanism similar to that of granulomatous diseases. We present a patient with hypercalcemia, normal parathyroid hormone, and parathyroid hormone-related protein levels but high calcitriol and ACE levels that, after further investigation, was diagnosed with bilateral adrenal non-Hodgkin's B-cell lymphoma. Primary adrenal lymphoma represents only 1% of all non-Hodgkin's lymphomas and is usually asymptomatic but should be considered by clinicians among the malignancies that cause calcitriol-mediated hypercalcemia.
authors.affiliation: Department of Internal Medicine, Reading Health System, West Reading, PA, USA; anarosaura@hotmail.com.
authors.forename: Ana
authors.initials: A
authors.lastname: Abaroa-Salvatierra
authors.affiliation: Department of Internal Medicine, Reading Health System, West Reading, PA, USA.
authors.forename: Bilal
authors.initials: B
authors.lastname: Shaikh
authors.affiliation: Department of Endocrinology and Diabetes Center, Reading Health System, West Reading, PA, USA.
authors.forename: Mrunalini
authors.initials: M
authors.lastname: Deshmukh
authors.affiliation: Department of Internal Medicine, Reading Health System, West Reading, PA, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Alweis
authors.affiliation: Department of Endocrinology and Diabetes Center, Reading Health System, West Reading, PA, USA.
authors.forename: Arti
authors.initials: A
authors.lastname: Patel
keywords: calcitriol-mediated hypercalcemia; non-Hodgkin’s lymphoma; primary adrenal lymphoma