title: The Diagnostic Value of Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Measurement Sera of Cervical Cancer Patients.
abstract: OBJECTIVE
  The aim of this study was to investigate a potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for cervical cancer.
  
  
  METHODS
  Blood samples were obtained from 43 women with cervical cancer. Isoenzymes class III, IV of ADH and total ADH activity were measured in the sera by the photometric method and class I, II ADH and ALDH activity by the fluorometric method.
  
  
  RESULTS
  The total activity of ADH and ADH I was significantly higher in the serum of patients with cervical cancer than in control groups. The diagnostic sensitivity for ADH I was 61,76%, specificity 65,7%, PPV and NPV were 70 and 62,16% respectively. AUC for ADH I was 0,654 and for total ADH 0,618.
  
  
  CONCLUSIONS
  The results suggest a potential role of ADH I as a marker for cervical cancer.
authors.affiliation: Department of Biochemical Diagnostics, Medical University, Bialystok, Poland orywalk@umb.edu.pl.
authors.forename: Karolina
authors.initials: K
authors.lastname: Orywal
authors.affiliation: Department of Biochemical Diagnostics, Medical University, Bialystok, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Jelski
authors.affiliation: Department of Gynecology, Medical University, Bialystok, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Zdrodowski
authors.affiliation: Department of Biochemical Diagnostics, Medical University, Bialystok, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D000328:Adult; D000368:Aged; D000426:Alcohol Dehydrogenase / Q000097:blood*; D000428:Alcohol Drinking / Q000009:adverse effects / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis*; D003043:Cocarcinogenesis; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D009367:Neoplasm Staging; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D002578:Uterine Cervical Dysplasia / Q000097:blood / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D009363:Neoplasm Proteins; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase
keywords: Alcohol metabolism; alcohol dehydrogenase isoenzymes; carcinogenesis; cervical cancer