title: [Resistance to anti-angiogenic therapy: a clinical and scientific current issue].
abstract: Although the use of anti-angiogenic agents has been considered a promising strategy to block tumor growth and improve the bioavailability of drugs into the tumor, the use of most of them in clinical trials is limited. The development of resistance to some anti-angiogenic agents and their high toxicity are currently under investigations. However, the approach is still valid since this therapeutic tool has lengthened survival of patients with colon, breast, kidney, lungs and liver cancers. The identification of biomarkers in response to this family of drugs is an important area of investigation.
authors.affiliation: Inserm UMR-S1165, université Paris Diderot, Sorbonne Paris Cité, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Inserm UMR-S1165, université Paris Diderot, Sorbonne Paris Cité, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: He
authors.initials: H
authors.lastname: Lu
authors.affiliation: Inserm UMR- S1140, université Paris Descartes, Sorbonne Paris Cité, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Boisson-Vidal
authors.affiliation: Microenvironnement et renouvellement cellulaire intégré (MERCI - EA 3829), faculté de médecine et de pharmacie, université de Rouen, France.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Inserm UMR-S1165, université Paris Diderot, Sorbonne Paris Cité, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Guilhem
authors.initials: G
authors.lastname: Bousquet
authors.affiliation: Inserm UMR-S1165, université Paris Diderot, Sorbonne Paris Cité, 1, avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Janin
authors.affiliation: Inserm UMR-S1165, université Paris Diderot, Sorbonne Paris Cité, 1, avenue Claude Vellefaux, 75010 Paris, France - Université Paris 13, avenue Jean-Baptiste Clément, 93430 Villetaneuse, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Di Benedetto
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D003131:Combined Modality Therapy; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors