title: Self-assembling N-(9-Fluorenylmethoxycarbonyl)-l-Phenylalanine hydrogel as novel drug carrier.
abstract: Supramolecular hydrogel as a novel drug carrier was prepared from N-(9-Fluorenylmethoxycarbonyl) (Fmoc) modified l-phenylalanine. Its different properties like stability at different pH, temperature and rheology were evaluated in reference to salicylic acid (SA) as a model drug, entrapped in the supramolecular hydrogel network. The release behaviour of SA drug in supramolecular hydrogel was investigated by UV-vis spectroscopy. The influence of hydrogelator, pH values of the accepting media, temperature and concentration of SA drug on the release behaviour was investigated under static conditions. The results indicated that the release rate of SA in the supramolecular hydrogels was slightly retarded with an increase of the hydrogelator concentration. Also, the release rates of SA increased with an increase of temperature and its concentration. Furthermore, the release behaviour of SA was found to be different at various pH values in buffers. The study of the release kinetics indicated that the release behaviour of SA from the carrier was in accord with the Peppas model and the diffusion controlled mechanism involved in the Fickian model.
authors.affiliation: Department of Biology, University of Dayton, Dayton, OH, USA; Department of Applied Mechanics, Motilal Nehru National Institute of Technology, Allahabad-211004, India.
authors.forename: Kirti
authors.initials: K
authors.lastname: Snigdha
authors.affiliation: Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad 211004, India.
authors.forename: Brijesh K
authors.initials: BK
authors.lastname: Singh
authors.affiliation: Department of Biology, University of Dayton, Dayton, OH, USA; Department of Applied Mechanics, Motilal Nehru National Institute of Technology, Allahabad-211004, India.
authors.forename: Abijeet Singh
authors.initials: AS
authors.lastname: Mehta
authors.affiliation: Department of Applied Mechanics, Motilal Nehru National Institute of Technology, Allahabad-211004, India.
authors.forename: R P
authors.initials: RP
authors.lastname: Tewari
authors.affiliation: Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad 211004, India. Electronic address: pkd_437@yahoo.com.
authors.forename: P K
authors.initials: PK
authors.lastname: Dutta
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D004339:Drug Compounding; D065546:Drug Liberation; D005449:Fluorenes / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D058105:Polymerization; D020156:Salicylic Acid / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D005449:Fluorenes; D020100:Hydrogels; D010649:Phenylalanine; D020156:Salicylic Acid
keywords: Drug carrier; Fmoc; Hydrogel; Phenylalanine; Self-assemble; Supramolecule