title: De Novo Belatacept in a Human Immunodeficiency Virus-Positive Kidney Transplant Recipient.
abstract: Benefits of belatacept-based immunosuppressive regimens in human immunodeficiency virus (HIV)-positive renal transplant recipients include avoidance of drug interactions between calcineurin inhibitors and highly active antiretroviral agents and decreased likelihood or severity of nonimmune toxicities such as new-onset diabetes after transplant, hyperlipidemia and hypertension. We report a successful case of de novo belatacept at >18 mo from transplant in an HIV-positive black man aged 50 years who received his first transplant from a living related kidney donor. To our knowledge, this case is the first reported of belatacept use in an HIV-positive renal transplant recipient.
authors.affiliation: Department of Pharmacy Services, Yale-New Haven Hospital, New Haven, CT.
authors.forename: E A
authors.initials: EA
authors.lastname: Cohen
authors.affiliation: Department of Surgery, Yale University, New Haven, CT.
authors.forename: D
authors.initials: D
authors.lastname: Mulligan
authors.affiliation: Department of Surgery, Yale University, New Haven, CT.
authors.forename: S
authors.initials: S
authors.lastname: Kulkarni
authors.affiliation: Department of Pharmacy Services, Yale-New Haven Hospital, New Haven, CT.
authors.forename: E M
authors.initials: EM
authors.lastname: Tichy
mesh_terms: D000069594:Abatacept / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000188:drug therapy* / Q000453:epidemiology; D006085:Graft Survival / Q000187:drug effects*; D015658:HIV Infections / Q000601:surgery* / Q000821:virology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery* / Q000821:virology; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D066027:Transplant Recipients
chemical_list: D007166:Immunosuppressive Agents; D000069594:Abatacept
keywords: clinical research/practice; fusion proteins and monoclonal antibodies: belatacept; immunosuppressant; immunosuppression/immune modulation; infection and infectious agents; kidney transplantation/nephrology; viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)