title: Is There an Association between Restless Legs Syndrome and Urticaria?
abstract: Restless legs syndrome (RLS) is a disease characterized by the urge to move the legs and sleep disturbances. Similarly, chronic spontaneous urticaria (CSU) is a dermatological disease characterized by pruritus and sleep disorders. In this study, we aimed to determine the prevalence and severity of RLS in patients with chronic spontaneous urticaria (CSU) and to compare the quality of sleep of patients with and without RLS in the CSU group using the Pittsburgh Sleep Quality Index. A total of 130 patients with CSU and 100 healthy controls were included in this study. The frequency of RLS, frequency of sleep disturbances, and average score of RLS in patients with CSU were statistically significantly higher than control groups (respectively P = 0.008, P = 0.009, P = 0.004). Subjective sleep quality, sleep latency and habitual sleep efficiency scores in patients with RLS were statistically significantly higher than patients without RLS (respectively P = 0.016, P = 0.007, P = 0.035). We claimed that pruritus of urticaria may decrease the quality of sleep in patients with RLS and it may trigger and worsen the restless legs syndrome. Furthermore, RLS and CSU may share a common etiology.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey .
authors.forename: Serpil
authors.identifier: 0000-0001-8717-1141
authors.initials: S
authors.lastname: Tuna
authors.affiliation: Department of Dermatology and Venereology, Akdeniz University School of Medicine, Antalya, Turkey .
authors.forename: Sevil
authors.identifier: 0000-0002-4233-0812
authors.initials: S
authors.lastname: Alan
authors.affiliation: Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey .
authors.forename: Nehir
authors.identifier: 0000-0002-0110-1650
authors.initials: N
authors.lastname: Samancı
authors.affiliation: Department of Dermatology and Venereology, Akdeniz University School of Medicine, Antalya, Turkey .
authors.forename: Ayşe Akman
authors.identifier: 0000-0002-5113-4178
authors.initials: AA
authors.lastname: Karakaş
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012148:Restless Legs Syndrome / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000209:etiology; D014581:Urticaria / Q000150:complications* / Q000175:diagnosis
keywords: Chronic Spontaneous Urticaria; Pittsburgh Sleep Quality Index; Restless Legs Syndrome; Sleep Quality