title: Imaging functional blood vessels by the laser speckle imaging (LSI) technique using Q-statistics of the generalized differences algorithm.
abstract: In this work, we report about q statistics concept to improve the performance of generalized differences algorithm based on intensity histogram for imaging functional blood vessel structures in a rodent window chamber of a mice. The method uses the dynamic speckle signals obtained by transilluminating the rodent window chamber to create activity maps of vasculatures. The proposed method of generalized differences with q statistics (GDq) is very sensitive to the values of defined parameters such as: camera exposure time, the q value and the camera frame number. Appropriate choice of q values enhances the visibility (contrast) of functional blood vessels but at the same time without sacrificing the spatial resolution, which is of utmost importance for in-vivo vascular imaging.
authors.affiliation: Biomedical Optics Laboratory, Department of Applied Physics, Indian School of Mines, Dhanbad, 826004 Jharkhand, India. Electronic address: mohamedzaheer1@gmail.com.
authors.forename: Mohammad Zaheer
authors.initials: MZ
authors.lastname: Ansari
authors.affiliation: Centro Multidisciplinario de Ciencias, Instituto Venezolano de Investigaciones Científicas, Mérida 5101, Venezuela; SPIE-ICTP Anchor Research in Optics Program Laboratory, International Centre for Theoretical Physics (ICTP), Strada Costiera 11, Trieste 34151, Italy.
authors.forename: Humberto
authors.initials: H
authors.lastname: Cabrera
authors.affiliation: Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, Calle 30, No. 502, Miramar, C. P. 11300 La Habana, Cuba.
authors.forename: Evelio E
authors.initials: EE
authors.lastname: Ramírez-Miquet
mesh_terms: D000465:Algorithms; D000818:Animals; D001783:Blood Flow Velocity; D001808:Blood Vessels / Q000000981:diagnostic imaging* / Q000502:physiology; D003627:Data Interpretation, Statistical; D007090:Image Interpretation, Computer-Assisted; D017078:Laser-Doppler Flowmetry / Q000706:statistics & numerical data; D051379:Mice; D055420:Perfusion Imaging / Q000379:methods* / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D014741:Video Recording
keywords: Functional blood vessel; Generalized differences; Laser speckle imaging