title: An update on potential therapeutic strategies for Parkinson's disease based on pathogenic mechanisms.
abstract: Parkinson's disease is a common neurodegenerative disorder mainly caused by the loss of nigral dopaminergic neurons, of which the pathogenesis remains essentially unknown. Current therapeutic strategies help manage signs and symptoms but have no effect in disease modification. Over the past several decades, scientists have devoted a lot of effort to clarifying the pathological mechanism and searching for new targets for Parkinson's disease treatment.
  
  
  
  Treatment of Parkinson's disease. Expert Commentary: Illustrated in this review are newly found discoveries and evidence that contribute to the understanding of Parkinson's disease pathogenic mechanism. Also discussed are potential therapeutic strategies that are being studied, including disease-modifying and genetically mediated small molecule compounds, cell- and gene-based therapeutic strategies, immunization strategies and anti-diabetic therapy, which may be very promising therapeutic methods in the future.
authors.affiliation: a Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Shen
authors.affiliation: a Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Pu
authors.affiliation: a Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Si
authors.affiliation: a Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
authors.forename: Rong
authors.initials: R
authors.lastname: Ye
authors.affiliation: a Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
authors.forename: Baorong
authors.initials: B
authors.lastname: Zhang
mesh_terms: D059290:Dopaminergic Neurons / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D010300:Parkinson Disease / Q000378:metabolism / Q000628:therapy*
keywords: Parkinson’s disease; anti-diabetic therapy; cell-based therapy; disease-modifying molecule compound; gene-based therapy; immunization strategy; pathogenic mechanism; therapeutic strategy