title: Using peptides to increase transport across the intestinal barrier.
abstract: The oral route is the preferred for the administration of drugs; however, it has some serious limitations. One of the main disadvantages is poor permeability across the intestinal barrier. Various approaches are currently being adopted to overcome this issue. In this review, we describe the alternatives that use peptides to enhance intestinal absorption. First, we define the various sources of peptide enhancers followed by the analysis of the absorption mechanism used. We then comment on the possible toxic effects derived from their use as permeation enhancers, as well as potential formulation strategies. Finally, the advantages and drawbacks of peptides as intestinal enhancers are examined.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac, 10, 08028 Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Navarro
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac, 10, 08028 Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac, 10, 08028 Barcelona, Spain; University of Barcelona, Department of Organic Chemistry, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Giralt
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac, 10, 08028 Barcelona, Spain. Electronic address: meritxell.teixido@irbbarcelona.org.
authors.forename: M
authors.initials: M
authors.lastname: Teixidó
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004339:Drug Compounding; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D010455:Peptides / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics*; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*
chemical_list: D010455:Peptides; D004364:Pharmaceutical Preparations