title: Novel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic.
abstract: Cancer-selective viral replication and delivery of a therapeutic immunomodulating, cancer-selective killing cytokine (mda-7/IL-24) by means of a newCancer Terminator Virus(CTV) combined with a small molecule BH3 mimetic holds promise for treating both primary and metastatic hormone refractory prostate cancer (CaP).
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University , Richmond, VA, USA.
authors.forename: Siddik
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University , Richmond, VA, USA.
authors.forename: Anjan
authors.initials: A
authors.lastname: Pradhan
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA, USA; VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Swadesh K
authors.initials: SK
authors.lastname: Das
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA, USA; VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Luni
authors.initials: L
authors.lastname: Emdad
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA, USA; VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Devanand
authors.initials: D
authors.lastname: Sarkar
authors.affiliation: Sanford-Burnham-Prebys Discovery Institute , La Jolla, CA, USA.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pellecchia
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA, USA; VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fisher
keywords: Cancer Terminator Virus (CTV); MDA-7/IL-24; Primary and Metastatic Prostate Cancer; Sabutoclax; Tumor-Specific Apoptosis; Immunotherapy; Ultrasound-Targeted Microbubble-Destruction (UTMD)