title: Determination of alternative preservatives in cosmetic products by chromophoric derivatization followed by vortex-assisted liquid-liquid semimicroextraction and liquid chromatography.
abstract: An analytical method for the simultaneous determination of phenethyl alcohol, methylpropanediol, phenylpropanol, caprylyl glycol, and ethylhexylglycerin, which are used as alternative preservatives in cosmetic products, has been developed. The method is based on liquid chromatography with UV spectrophotometric detection after chromophoric derivatization with benzoyl chloride and vortex-assisted liquid-liquid semimicroextraction. Different chromatographic parameters, derivatization conditions, and sample preparation variables were studied. Under optimized conditions, the limits of detection values for the analytes ranged from 0.02 to 0.06µgmL(-1). The method was validated with good recovery values (84-118%) and precision values (3.9-9.5%). It was successfully applied to 10 commercially available cosmetic samples. The good analytical features of the proposed method besides of its environmentally-friendly characteristics, make it useful to carry out the quality control of cosmetic products containing the target compounds as preservative agents.
authors.affiliation: Departamento de Química Analítica, Facultad de Química, Universitat de València, 46100 Burjassot, Valencia, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Miralles
authors.affiliation: Departamento de Química Analítica, Facultad de Química, Universitat de València, 46100 Burjassot, Valencia, Spain.
authors.forename: Ilianna
authors.initials: I
authors.lastname: Vrouvaki
authors.affiliation: Departamento de Química Analítica, Facultad de Química, Universitat de València, 46100 Burjassot, Valencia, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Chisvert
authors.affiliation: Departamento de Química Analítica, Facultad de Química, Universitat de València, 46100 Burjassot, Valencia, Spain. Electronic address: amparo.salvador@uv.es.
authors.forename: Amparo
authors.initials: A
authors.lastname: Salvador
mesh_terms: D002853:Chromatography, Liquid; D003358:Cosmetics; D010626:Phenylethyl Alcohol; D011310:Preservatives, Pharmaceutical
chemical_list: D003358:Cosmetics; D011310:Preservatives, Pharmaceutical; D010626:Phenylethyl Alcohol
keywords: Alternative preservatives; Cosmetic products; Liquid chromatography