title: Medicinal Chemistry Perspective of Fused Isoxazole Derivatives.
abstract: Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.
authors.forename: Mahesh A
authors.initials: MA
authors.lastname: Barmade
authors.forename: Prashant R
authors.initials: PR
authors.lastname: Murumkar
authors.forename: Mayank Kumar
authors.initials: MK
authors.lastname: Sharma
authors.affiliation: Faculty of Pharmacy, Kalabhavan, The Maharaja Sayajirao University of Baroda, Vadodara- 390 001, Gujarat, India. mryadav11@yahoo.co.in.
authors.forename: Mange Ram
authors.initials: MR
authors.lastname: Yadav
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002493:Central Nervous System Diseases / Q000188:drug therapy; D002626:Chemistry, Pharmaceutical; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use; D007555:Isoxazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007004:Hypoglycemic Agents; D007555:Isoxazoles