title: High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China.
abstract: BACKGROUND
  Birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated.
  
  
  METHODS
  Sera from 203 allergic patients from the northern part of China and collected during February to July 2014 were investigated. Specific immunoglobulin E (IgE) against birch pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean allergen Gly m 4 specific IgE was measured by ImmunoCAP 100.
  
  
  RESULTS
  Among the 203 sera, 34 sera (16.7%) had specific IgE to Bet v and of these, 28 sera (82.4%) contained Bet v 1-specific IgE. Among the 28 sera with Bet v 1-specific IgE, 27 sera (96.4%) contained Mal d 1-specific IgE and 22 sera (78.6%) contained Gly m 4-specific IgE. Of the 34 Bet v-positive sera, 6 sera (17.6%) contained no specific IgE for Bet v 1, Mal d 1, or Gly m 4. Almost all Bet v-positive sera were donated during the birch pollen season.
  
  
  CONCLUSIONS
  The prevalence of birch allergy among patients visiting health care during pollen season can be as high as 16.7% in Tangshan City. The majority of Chinese birch allergic patients are IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major apple allergen Mal d 1 and soy bean allergen Gly m 4. A relatively high number of patients (17.6%) are IgE-sensitized to birch pollen allergen(s) other than Bet v 1. The high prevalence of specific IgE to Mal d 1 and Gly m 4 among Bet v 1-sensitized patients indicates that pollen-food allergy syndrome could be of clinical relevance in China.
authors.affiliation: Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Hao
authors.affiliation: ALK China Research, ALK, Guangzhou 510300, China.
authors.forename: Yi-Wu
authors.initials: YW
authors.lastname: Zheng
authors.affiliation: Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Wang
authors.affiliation: Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
authors.forename: Xing-Ai
authors.initials: XA
authors.lastname: Kong
authors.affiliation: Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
authors.forename: Zhi-Jing
authors.initials: ZJ
authors.lastname: Song
authors.affiliation: ALK China Research, ALK, Guangzhou 510300, China.
authors.forename: Xu-Xin
authors.initials: XX
authors.lastname: Lai
authors.affiliation: ALK China Research, ALK, Guangzhou 510300, China.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Spangfort
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000737:chemistry*; D052179:Antigens, Plant / Q000737:chemistry; D029662:Betula; D002648:Child; D002675:Child, Preschool; D002681:China; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000737:chemistry*; D027845:Malus / Q000737:chemistry*; D008875:Middle Aged; D010940:Plant Proteins / Q000737:chemistry; D011058:Pollen / Q000737:chemistry*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D013025:Glycine max / Q000737:chemistry*; D055815:Young Adult
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D010940:Plant Proteins; D007073:Immunoglobulin E
keywords: Apple; Birch; Cross-reaction; Pollen-food allergy; Soy; Specific immunoglobulin E (IgE)