title: Potential of Excipient Emulsions for Improving Quercetin Bioaccessibility and Antioxidant Activity: An in Vitro Study.
abstract: The potential for excipient emulsions to enhance the bioaccessibility and antioxidant activity of quercetin was determined in this study. Oil-in-water excipient emulsions containing two levels (4 or 10%) of small lipid droplets (d < 250 nm) were prepared from a long-chain triglyceride (corn oil). The solubilization of quercetin by the excipient emulsions was faster than by bulk corn oil or bulk water, and the solubilization rate was higher at 100 °C than at 30 °C. The bioaccessibility of quercetin samples was determined using an in vitro gastrointestinal model, and the bioactivity of quercetin was determined using a rat feeding study. The excipient emulsions were more effective at enhancing quercetin bioaccessibility and rat plasma antioxidant activity than either bulk oil or bulk water. This effect was attributed to the rapid digestion of the long chain triglycerides when they were in an emulsified form, which led to the rapid production of mixed micelles capable of solubilizing, protecting, and transporting quercetin.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University , No. 235 Nanjing East Road, Nanchang 330047, Jiangxi China.
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University , No. 235 Nanjing East Road, Nanchang 330047, Jiangxi China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zou
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University , No. 235 Nanjing East Road, Nanchang 330047, Jiangxi China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Food Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.|Department of Biochemistry, Faculty of Science, King Abdulaziz University , P.O. Box 80203, Jeddah 21589, Saudi Arabia.
authors.forename: David Julian
authors.initials: DJ
authors.lastname: McClements
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D019587:Dietary Supplements / Q000032:analysis; D004063:Digestion; D004655:Emulsions / Q000737:chemistry / Q000493:pharmacokinetics; D005079:Excipients / Q000737:chemistry* / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000378:metabolism; D008297:Male; D011794:Quercetin / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D004655:Emulsions; D005079:Excipients; D011794:Quercetin
keywords: bioaccessibility; bioavailability; excipient emulsions; in vitro digestion; plasma antioxidant power; quercetin