title: Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs.
abstract: A microtubule targeted peptide-based delivery vehicle has been designed using two oppositely charged peptides, which targets tubulin/microtubules, delivers both hydrophilic and hydrophobic drugs into their target site through lysosome at acidic pH. Drug loaded vesicles show a significant anticancer effect compared to control drugs in a 2D monolayer and a 3D spheroid cell.
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India. sghosh@iicb.res.in.
authors.forename: Anindyasundar
authors.initials: A
authors.lastname: Adak
authors.forename: Saswat
authors.initials: S
authors.lastname: Mohapatra
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Mondal
authors.forename: Batakrishna
authors.initials: B
authors.lastname: Jana
authors.forename: Surajit
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008247:Lysosomes / Q000737:chemistry; D008870:Microtubules / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides