title: Transcriptional regulation of mast cell and basophil lineage commitment.
abstract: Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances in the understanding of origin and molecular regulation of mouse and human basophil and mast cell development. A more complete understanding of how basophils and mast cells develop at the molecular level will lead to development of interventions that are more effective in achieving long-term success.
authors.affiliation: Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA. huangh@njhealth.org.|Department of Immunology and Microbiology, University of Colorado School of Medicine, Denver, CO, 80206, USA. huangh@njhealth.org.|Department of Biomedical Research, National Jewish Health and Department of Immunology and Microbiology, University of Colorado School of Medicine, 1400 Jackson Street, Denver, CO, 80206, USA. huangh@njhealth.org.
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA.
authors.forename: Yapeng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA.|Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D001491:Basophils / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics; D005786:Gene Expression Regulation; D055014:Granulocyte-Macrophage Progenitor Cells / Q000166:cytology / Q000378:metabolism; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D008407:Mast Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D051739:Microphthalmia-Associated Transcription Factor / Q000378:metabolism; D009928:Organ Specificity / Q000235:genetics; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D051739:Microphthalmia-Associated Transcription Factor; D014157:Transcription Factors
keywords: Basophils; Bi-potential basophil/mast cell progenitors; Lineage commitment; Mast cells