title: Clinical presentation and management of suspected ribavirin toxicosis in a dog.
abstract: A 5-month-old pit bull terrier was presented for evaluation of progressive lethargy, vomiting, diarrhea, and anorexia 45 hours after ingestion of 625 mg/kg body weight (BW) (9000 mg) of the antiviral medication, ribavirin. Abnormalities that were detected included dehydration, tachycardia, elevated liver enzymes, and prolonged prothrombin time. The dog was discharged after 5 days of aggressive supportive care consisting of intravenous fluids, antiemetics, gastroprotectants, hepatoprotectants, dextrose supplementation, and vitamin B/K1 supplementation.
authors.affiliation: New England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).
authors.forename: Kimberly
authors.initials: K
authors.lastname: Bridges
authors.affiliation: New England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).
authors.forename: Nicole
authors.initials: N
authors.lastname: Beckel
authors.affiliation: New England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).
authors.forename: Claire
authors.initials: C
authors.lastname: Sharp
authors.affiliation: New England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).
authors.forename: Laura
authors.initials: L
authors.lastname: Stern
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D004285:Dogs; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000662:veterinary; D012254:Ribavirin / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin