title: Clinical evaluation of (18)F-fludeoxyglucose positron emission tomography/CT using point spread function reconstruction for nodal staging of colorectal cancer.
abstract: OBJECTIVE
  For patients with colorectal cancer, lymph node metastasis is a very important factor for prognostic and treatment determinations. Fluorine-18 fludeoxyglucose positron emission tomography/CT ((18)F-FDG-PET/CT) is among the useful tools for detecting lymph node metastasis. Recently, a new (18)F-FDG-PET/CT reconstruction technique for improving spatial resolution and signal-to-noise ratios, point spread function (PSF), has become available. We assessed the effect of PSF reconstruction on standardized uptake values and its diagnostic accuracy for lymph node staging in patients with colorectal cancer.
  
  
  METHODS
  We retrospectively analysed records from patients with colorectal cancer who underwent (18)F-FDG-PET/CT for pre-operative staging. All positron emission tomography CT (PET/CT) examinations were reconstructed using ordered subset expectation maximization (OSEM) and OSEM + PSF. We compared sensitivities, specificities, positive-predictive values (PPVs), negative-predictive values (NPVs) and accuracies of conventional PET/CT (reconstructed with OSEM) and PSF-PET/CT (reconstructed with OSEM + PSF) for identifying lymph node metastases. We also analysed the diagnostic confidence level on a 5-point scale.
  
  
  RESULTS
  With conventional PET/CT, the sensitivity, specificity, PPV, NPV and accuracy were 53.1%, 99.1%, 94.4%, 88.3% and 89.1%, respectively. With PSF PET/CT, the corresponding values were 65.6%, 99.1%, 95.4%, 91.2% and 91.8%, respectively. Conventional PET/CT and PSF PET/CT did not differ significantly in terms of N-stage definition (p = 0.125). However, the diagnostic confidence level of PSF PET/CT was significantly higher than that of conventional PET/CT (p < 0.01).
  
  
  CONCLUSIONS
  PSF reconstruction might slightly increase sensitivity without impairing specificity. Moreover, this technique is expected to facilitate more confident radiological decisions when compared with conventional PET/CT. Advance in knowledge: This study demonstrates the clinical effectiveness of PSF PET/CT for lymph node staging in colorectal cancer.
authors.affiliation: 1 Department of Radiology, Iwate Medical University, Morioka, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kawashima
authors.affiliation: 1 Department of Radiology, Iwate Medical University, Morioka, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kato
authors.affiliation: 1 Department of Radiology, Iwate Medical University, Morioka, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Tomabechi
authors.affiliation: 1 Department of Radiology, Iwate Medical University, Morioka, Japan.
authors.forename: Mikaru
authors.initials: M
authors.lastname: Matsuo
authors.affiliation: 2 Department of Surgery, Iwate Medical University, Morioka, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Otsuka
authors.affiliation: 3 Department of Pathology, Iwate Medical University, Morioka, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ishida
authors.affiliation: 4 PET Linac Center, Iwate Medical University, Morioka, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakamura
authors.affiliation: 1 Department of Radiology, Iwate Medical University, Morioka, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ehara
mesh_terms: D000465:Algorithms; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D059629:Signal-To-Noise Ratio
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18