title: Nutraceuticals in Parkinson's Disease.
abstract: Current pharmacological strategies for Parkinson's disease (PD), the most common neurological movement disorder worldwide, are predominantly symptom relieving and are often plagued with undesirable side effects after prolonged treatment. Despite this, they remain as the mainstay treatment for PD due to the lack of better alternatives. Nutraceuticals are compounds derived from natural food sources that have certain therapeutic value and the advent of which has opened doors to the use of alternative strategies to tackle neurodegenerative diseases such as PD. Notably, nutraceuticals are able to position themselves as a "safer" strategy due to the fact that they are naturally derived compounds, therefore possibly having less side effects. Significant efforts have been put into better comprehending the role of nutraceuticals in PD, and we will look at some of them in this review. Broadly speaking, these compounds execute their positive effects via modulating signalling pathways, inhibiting oxidative stress, inflammation and apoptosis, as well as regulating mitochondrial homoeostasis. Importantly, we will highlight how a component of green tea, epigallocatechin-3-gallate (EGCG), confers neuroprotection in PD via its ability to activate AMP kinase and articulate how its beneficial effects in PD are possibly due to enhancing mitochondrial quality control.
authors.affiliation: Neurodegeneration Research Laboratory, National Neuroscience Institute, 11, Jalan Tan Tock Seng, Singapore, 308433, Singapore.|Department of Physiology, National University of Singapore, Singapore, Singapore.|NUS Graduate School for Integrative Sciences and Engineering, Singapore, Singapore.
authors.forename: Liting
authors.initials: L
authors.lastname: Hang
authors.affiliation: Neurodegeneration Research Laboratory, National Neuroscience Institute, 11, Jalan Tan Tock Seng, Singapore, 308433, Singapore.
authors.forename: Adeline Henry
authors.initials: AH
authors.lastname: Basil
authors.affiliation: Neurodegeneration Research Laboratory, National Neuroscience Institute, 11, Jalan Tan Tock Seng, Singapore, 308433, Singapore. phslkl@nus.edu.sg.|NUS Graduate School for Integrative Sciences and Engineering, Singapore, Singapore. phslkl@nus.edu.sg.|Duke-NUS Medical School, Singapore, Singapore. phslkl@nus.edu.sg.
authors.forename: Kah-Leong
authors.initials: KL
authors.lastname: Lim
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives / Q000378:metabolism; D019587:Dietary Supplements; D006801:Humans; D018696:Neuroprotective Agents / Q000378:metabolism; D010300:Parkinson Disease / Q000628:therapy*
chemical_list: D018696:Neuroprotective Agents; D002392:Catechin; C045651:epigallocatechin gallate
keywords: AMPK; Mitochondria; Neurodegeneration; Parkin; Parkinson’s disease