title: Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP).
abstract: We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1β and IL6), and the serum levels of tumour necrosis factor-α (TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and IL6 differed significantly (all p values < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p > 0.05). The TNFα and IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1β level was higher in the study group but did not increase as the ISS increased. IL6 and TNFα levels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNFα levels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1β level is useful for this purpose.
authors.affiliation: Department of Emergency Medicine, Klinikum Fürth Zentrale Notaufnahme, 90766 Fürth, Germany.
authors.forename: Baris
authors.initials: B
authors.lastname: Alper
authors.affiliation: Department of Otolaryngology, Medipol University Healthcare and Research Center Esenler Hospital, 34230 Istanbul, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Erdogan
authors.affiliation: Department of Emergency Medicine, Haydarpasa Numune Training and Research Hospital, 34668 Istanbul, Turkey.
authors.forename: Mehmet Özgür
authors.initials: MÖ
authors.lastname: Erdogan
authors.affiliation: Department of Emergency Medicine, Göztepe Medicalpark Hospital, 34732 Istanbul, Turkey.
authors.forename: Korkut
authors.initials: K
authors.lastname: Bozan
authors.affiliation: Department of Biochemistry, Bulent Ecevit University Hospital, 67600 Zonguldak, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Can
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000276:immunology / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014947:Wounds and Injuries / Q000097:blood* / Q000276:immunology / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein