title: Thoughts on Obesity and Brain Glucose.
abstract: Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer's disease.
authors.affiliation: DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Heneka
authors.affiliation: DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany. Electronic address: pierluigi.nicotera@dzne.de.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Nicotera
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D059305:Diet, High-Fat; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000378:metabolism
chemical_list: D005947:Glucose