title: Synthesis of the olanzapine labeled by carbon-14.
abstract: Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-(14) C].
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Semnan University, PO Box: 35131-19111, Semnan, Iran.
authors.forename: Naghi
authors.initials: N
authors.lastname: Saadatjoo
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Semnan University, PO Box: 35131-19111, Semnan, Iran.|Applied Radiations Research School, Nuclear Science & Technology Research Institute, Karegare Shomali Street, P.O. Box 11365-3486, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Javaheri
authors.affiliation: Applied Radiations Research School, Nuclear Science & Technology Research Institute, Karegare Shomali Street, P.O. Box 11365-3486, Tehran, Iran.
authors.forename: Nader
authors.initials: N
authors.lastname: Saemian
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amini
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002250:Carbon Radioisotopes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D007553:Isotope Labeling; D000077152:Olanzapine
chemical_list: D002250:Carbon Radioisotopes; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: antipsychotic; carbon-14; olanzapine