title: Animal models of monogenic migraine.
abstract: Migraine is a highly prevalent and disabling neurological disorder with a strong genetic component. Rare monogenic forms of migraine, or syndromes in which migraine frequently occurs, help scientists to unravel pathogenetic mechanisms of migraine and its comorbidities. Transgenic mouse models for rare monogenic mutations causing familial hemiplegic migraine (FHM), cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and familial advanced sleep-phase syndrome (FASPS), have been created. Here, we review the current state of research using these mutant mice. We also discuss how currently available experimental approaches, including epigenetic studies, biomolecular analysis and optogenetic technologies, can be used for characterization of migraine genes to further unravel the functional and molecular pathways involved in migraine.
authors.affiliation: Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan Faculty of Medicine, National Yang-Ming University School of Medicine, Taiwan Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, USA.
authors.forename: Shih-Pin
authors.initials: SP
authors.lastname: Chen
authors.affiliation: Departments of Human Genetics and Neurology, Leiden University Medical Centre, the Netherlands.
authors.forename: Else A
authors.initials: EA
authors.lastname: Tolner
authors.affiliation: Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, USA khaerter@mgh.harvard.edu.
authors.forename: Katharina
authors.initials: K
authors.lastname: Eikermann-Haerter
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008881:Migraine Disorders / Q000235:genetics*
keywords: Genetic animal model; migraine without aura; pathophysiology