title: Androgen control of lipid metabolism in prostate cancer: novel insights and future applications.
abstract: One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.
authors.affiliation: School of MedicineUniversity of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Butler
authors.affiliation: School of MedicineUniversity of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Centenera
authors.affiliation: Laboratory of Lipid Metabolism and CancerDepartment of Oncology, LKI - Leuven Cancer Institute, KU Leuven - University of Leuven, Leuven, Belgium johan.swinnen@med.kuleuven.be.
authors.forename: Johannes V
authors.initials: JV
authors.lastname: Swinnen
mesh_terms: D000728:Androgens / Q000378:metabolism*; D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*
chemical_list: D000728:Androgens
keywords: androgens; lipid metabolism; lipidomics; lipogenic enzymes; phospholipids; prostate cancer