title: Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention.
abstract: The preprocedural neutrophil-lymphocyte ratio (NLR) is related to adverse outcomes in patients with coronary artery disease. We hypothesized that high NLR is a predictor of cardiac death after percutaneous coronary intervention (PCI). The objective of this investigation was to assess the associations of NLR, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the occurrence of cardiac death after PCI.
  
  
  
  The NLR, hs-cTnT and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary end point was cardiac death.
  
  
  
  The median NLR was 2.3 (interquartile range: 1.5-4.1). There were 21 cardiac death events during a mean follow-up duration of 25.8 months. With the NLR cutoff level set to 3.3 using the receiver-operating characteristic curve, the sensitivity and specificity for differentiating between the group with cardiac death and the group without cardiac death were 85.7% and 59.3%, respectively. Kaplan-Meier analysis revealed that the higher NLR group (≥3.3) had a significantly higher cardiac death rate than the lower NLR group (<3.3) (11.1% versus 1.4%, log-rank: P < 0.0001). This value was more useful in patients with heart failure (NT-proBNP ≥ 300ng/L) or myocardial injury (hs-cTnT ≥ 100ng/L).
  
  
  
  The outcomes of the current study demonstrate that high NLR is a predictor of cardiac death after PCI, especially in patients with heart failure or myocardial injury.
authors.affiliation: Department of Family Medicine, Chosun University Hospital, Dong-Gu, Gwangju, South Korea.
authors.forename: Sam Cheol
authors.initials: SC
authors.lastname: Kim
authors.affiliation: Department of Emergency Medicine, Inje University Haeundae Paik Hospital, Haeundae-Gu, Busan, Korea.
authors.forename: Kyung-Hoon
authors.initials: KH
authors.lastname: Sun
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Dong-Gu, Gwangju, South Korea. Electronic address: dhchoi@chosun.ac.kr.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Dong-Gu, Gwangju, South Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Dong-Gu, Gwangju, South Korea.
authors.forename: Seo-Won
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Department of Laboratory Medicine, Chosun University School of Medicine, Dong-Gu, Gwangju, South Korea; Research Center for Resistance Cells, Chosun University School of Medicine, Dong-Gu, Gwangju, South Korea.
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Dong-Gu, Gwangju, South Korea.
authors.forename: Keun Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Dong-Gu, Gwangju, South Korea.
authors.forename: Heesang
authors.initials: H
authors.lastname: Song
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003643:Death; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000401:mortality*; D056910:Republic of Korea / Q000453:epidemiology; D020107:Troponin T / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Cardiac death; NT-proBNP; Neutrophil-lymphocyte ratio; Percutaneous coronary intervention; Troponin T