title: Silent myocardial ischemia in asymptomatic patients with type 2 diabetes mellitus without previous histories of cardiovascular disease.
abstract: BACKGROUND
  The number of patients with type 2 diabetes mellitus (T2DM) continues to increase all over the world. Cardiovascular disease (CVD), especially coronary artery disease (CAD), is a major cause of the morbidity and mortality in patients with T2DM. The prognosis of patients with silent myocardial ischemia (SMI) is worse than that in those without.
  
  
  RESULTS
  Thus, to assess how many patients with SMI existed among those patients, CVD screening tests were performed in 128 asymptomatic patients with T2DM without previous histories of CVD. SMI could be detected in 24 patients (19%) by exercise stress tests and/or the coronary fractional flow reserve. Their 12-lead electrocardiogram and cardiac ultrasonography were both normal. Compared to those without SMI, those with had a statistically significant longer history of T2DM (17±1 versus 11±1years, p=0.006), and the co-existence of a family history of CVD (42% versus 21%, p=0.037). Furthermore, these factors were demonstrated as independent risk factors of SMI by a multivariate analysis (Odds ratio 1.060 and 4.000, respectively), and in accordance with the disease duration of T2DM, the prevalence of patients with SMI has been increasing (p=0.019).
  
  
  CONCLUSIONS
  Physicians should be aware of these conditions when examining patients with T2DM, especially with a family history of CVD and/or long disease duration (>11years) of T2DM, even though they have no symptoms, previous histories of CVDs, and/or abnormal findings on the 12-lead electrocardiogram and cardiac ultrasonography. This may be an effective, safe, and attractive diagnostic strategy for those asymptomatic patients with T2DM.
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawano
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan. Electronic address: matakemo@suikokai.or.jp.
authors.forename: Masao
authors.initials: M
authors.lastname: Takemoto
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mito
authors.affiliation: Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Morisaki
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sakaki
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Atsutoshi
authors.initials: A
authors.lastname: Matsuo
authors.affiliation: Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Abe
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Hida
authors.affiliation: Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Mukae
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Teiji
authors.initials: T
authors.lastname: Okazaki
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Kei-Ichiro
authors.initials: K
authors.lastname: Tayama
authors.affiliation: Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan.
authors.forename: Toyoshi
authors.initials: T
authors.lastname: Inoguchi
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Kiyonobu
authors.initials: K
authors.lastname: Yoshitake
authors.affiliation: Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kosuga
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000453:epidemiology*; D016017:Odds Ratio; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors
keywords: Asymptomatic; Diabetes mellitus; Disease duration; Family history; Silent myocardial ischemia