title: Associations between first-trimester uterine artery Doppler velocimetry indices and adverse perinatal outcomes in women conceiving via in vitro fertilization.
abstract: OBJECTIVE
  To explore if first-trimester uterine artery Doppler velocimetric values might predict adverse perinatal outcomes in patients conceiving via in vitro fertilization (IVF).
  
  
  METHODS
  We evaluated pregnancies in women who conceived via IVF (Group 1, n = 62) and compared these subjects to a control group (spontaneous pregnancies; Group 2, n = 53) in terms of first-trimester uterine artery Doppler velocimetric data. We explored whether these data predicted adverse perinatal outcomes (need for cesarean delivery, preterm birth, low birth weight, lower APGAR score, and need for referral to a neonatal intensive care unit [NICU]).
  
  
  RESULTS
  The mean age of Group 1 patients was 29.9 ± 4.7 years and that of Group 2 was 27.2 ± 4.2 years. Gestational age at birth, first-minute APGAR scores, NICU referral rate, birth weight, preterm birth rate, abortion rate, delivery type, the left-side uterine arterial systole-diastole ratio (LUASD), the left-side uterine arterial resistance index (LUARI), the right-side uterine arterial systole-diastole ratio (RUASD), and the right-side uterine arterial resistance index (RUARI) differed significantly between the two groups (all p values < 0.05). In the study group, positive correlations were evident between LUASD, LUARI, RUASD, and RUARI, preterm birth rates, and NICU referral rates. Also, birth weight correlated negatively with LUASD, LUARI, RUASD, and RUARI in the study group.
  
  
  CONCLUSIONS
  First-trimester uterine artery Doppler velocimetric indices, including the resistance index and systole-diastole ratio, usefully predict adverse perinatal outcomes of IVF pregnancies.
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Timur
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Çinar
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Hançerlioğullari
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Mihriban
authors.initials: M
authors.lastname: Alkan
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: İnal
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Nafiye
authors.initials: N
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D001034:Apgar Score; D016022:Case-Control Studies; D002585:Cesarean Section; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First; D047928:Premature Birth / Q000209:etiology*; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance / Q000502:physiology; D055815:Young Adult
keywords: Adverse perinatal outcomes; Doppler indices; IVF pregnancy