title: Janus Nanocage toward Platelet Delivery.
abstract: The platelet-shaped Janus nanocages with a mesoporous silica shell are prepared. PEG moiety onto the exterior surface is responsible for good dispersity in water. The graphene sheet inside the cavity is responsible for hydrophobic performance to selectively capture hydrophobic species, and photothermal effect by NIR irradiation. As a biocompatible DOX-loaded Janus platelet delivery, HeLa cell cytotoxicity is greatly enhanced under NIR irradiation. There exists a synergetic effect between the chemotherapy and photothermal therapy.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Saina
authors.initials: S
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Fuxin
authors.initials: F
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Qu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Yang
mesh_terms: D001792:Blood Platelets; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*
chemical_list: D006108:Graphite; D004317:Doxorubicin
keywords: Janus; NIR; delivery; graphene; nanocage