title: Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects.
abstract: This study aimed to evaluate the relationship between the cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. A cross-sectional study was conducted with a random and representative sample of 142 elderly subjects selected by cluster and recruited from a municipal assistance program. Clinical, nutritional, biochemical and inflammatory profiles, oxidative stress and genotyping for the BsmI polymorphism were evaluated. Participants had mean age of 69.9 (7.0) years, BMI of 28.3 (4.4) kg/m(2) and 80.3% were women. The prevalence of a 25-hydroxyvitamin D [25(OH)D] status <75nmol/L was 40.8%. A vitamin D level<75nmol/L was found to be associated with gender and fish consumption. The INSUF/DEF group [25(OH)D<75nmol/L] showed higher fasting blood glucose MDA values when compared to the SUF group [25(OH)D≥75nmol/L]; this relationship was maintained only for women in the analysis by sex. The BsmI polymorphism showed allelic frequencies in the SUF group of B 49% and b 51% and in the INSUF/DEF group B 38% and b 62%. The frequency of bb homozygosity was significantly associated with lower serum total cholesterol and LDL cholesterol concentrations compared to Bb, both in the general population and in the SUF group. Among individuals with bb, the INSUF/DEF group showed higher levels of triglycerides and VLDL cholesterol. Blood glucose levels and oxidative stress were increased in elderly subjects with 25(OH)D<75nmol/L. The presence of the bb genotype with adequate vitamin D status resulted in lower total and LDL cholesterol, but the benefit was lost when vitamin D insufficiency or deficiency was present.
authors.affiliation: Pós-graduação em Ciências da Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, PB/Brazil. Electronic address: chahiraissa@hotmail.com.
authors.forename: Chahira Taha Mahd Ibrahim
authors.initials: CT
authors.lastname: Issa
authors.affiliation: Programa de Pós-graduação em Ciências da Nutrição, Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, PB/Brazil.
authors.forename: Alexandre Sérgio
authors.initials: AS
authors.lastname: Silva
authors.affiliation: Pós-graduação em Ciências da Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, PB/Brazil.
authors.forename: Luciana Tavares
authors.initials: LT
authors.lastname: Toscano
authors.affiliation: Graduação em Ciências da Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, PB/Brazil.
authors.forename: Marcia Silva
authors.initials: MS
authors.lastname: Medeiros
authors.affiliation: Centro de Ciências Exatas e da Natureza/Departamento de Biologia Molecular, Universidade Federal da Paraíba, PB/Brazil.
authors.forename: Darlene Camati
authors.initials: DC
authors.lastname: Persuhn
authors.affiliation: Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Campus I, CEP 50.670.901, PE/Brazil.
authors.forename: Alcides
authors.initials: A
authors.lastname: da Silva Diniz
authors.affiliation: Programa de Pós-graduação em Ciências da Nutrição, Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, PB/Brazil.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: de Carvalho Costa
authors.affiliation: Programa de Pós-graduação em Ciências da Nutrição, Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, PB/Brazil.
authors.forename: Maria da Conceição
authors.initials: Mda C
authors.lastname: Rodrigues Gonçalves
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood*; D001786:Blood Glucose; D001938:Brazil; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014807:Vitamin D; D008315:Malondialdehyde; C104450:25-hydroxyvitamin D
keywords: Elderly; Hyperglycemia; Oxidative stress; Polymorphism; Vitamin D