title: The role of sirtuins in cellular homeostasis.
abstract: Sirtuins are evolutionarily conserved nicotinamide adenine dinucleotide (NAD(+))-dependent lysine deacylases or ADP-ribosyltransferases. These cellular enzymes are metabolic sensors sensitive to NAD(+) levels that maintain physiological homeostasis in the animal and plant cells.
authors.affiliation: Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, ul. Świętokrzyska 15, 25-406, Kielce, Poland.
authors.forename: Wioleta
authors.initials: W
authors.lastname: Kupis
authors.affiliation: Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, ul. Świętokrzyska 15, 25-406, Kielce, Poland. jan.palyga@ujk.edu.pl.
authors.forename: Jan
authors.initials: J
authors.lastname: Pałyga
authors.affiliation: Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, ul. Świętokrzyska 15, 25-406, Kielce, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Tomal
authors.affiliation: Institute of Plant Physiology, Polish Academy of Sciences, Niezapominajek 21, 30-239, Kraków, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Niewiadomska
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000818:Animals; D020134:Catalytic Domain; D017124:Conserved Sequence; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology; D008954:Models, Biological; D009243:NAD / Q000378:metabolism; D010940:Plant Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology; D021381:Protein Transport / Q000187:drug effects; D037761:Sirtuins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D013045:Species Specificity; D013379:Substrate Specificity
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D010940:Plant Proteins; D009243:NAD; D037761:Sirtuins
keywords: Deacetylation; Deacylation; Mammalian and plant sirtuins; Mono-ADP-ribosylation; Sirtuin activators and inhibitors