title: Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines.
abstract: With increasing demand for donor organs for transplantation, machine perfusion (MP) promises to be a beneficial alternative preservation method for donor livers, particularly those considered to be of suboptimal quality, also known as extended criteria donor livers. Over the last decade, numerous studies researching MP of donor livers have been published and incredible advances have been made in both experimental and clinical research in this area. With numerous research groups working on MP, various techniques are being explored, often applying different nomenclature. The objective of this review is to catalog the differences observed in the nomenclature used in the current literature to denote various MP techniques and the manner in which methodology is reported. From this analysis, we propose a standardization of nomenclature on liver MP to maximize consistency and to enable reliable comparison and meta-analyses of studies. In addition, we propose a standardized set of guidelines for reporting the methodology of future studies on liver MP that will facilitate comparison as well as clinical implementation of liver MP procedures.
authors.affiliation: Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.|Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: S A
authors.initials: SA
authors.lastname: Karangwa
authors.affiliation: Department of Surgery & Transplantation, University Hospital Zurich, Zurich, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Dutkowski
authors.affiliation: Thomas E. Starzl Transplantation Institute Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.|McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.
authors.forename: P
authors.initials: P
authors.lastname: Fontes
authors.affiliation: Nuffield Department of Surgery, Oxford Transplant Centre, University of Oxford, Churchill Hospital, Oxford, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Friend
authors.affiliation: Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, NY.
authors.forename: J V
authors.initials: JV
authors.lastname: Guarrera
authors.affiliation: Transplant Center, Massachusetts General Hospital, Boston, MA.
authors.forename: J F
authors.initials: JF
authors.lastname: Markmann
authors.affiliation: Liver Unit, University Hospital Birmingham, Birmingham, UK.
authors.forename: H
authors.identifier: 0000-0001-5480-9380
authors.initials: H
authors.lastname: Mergental
authors.affiliation: Department of Surgical Research, Clinic for General Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Minor
authors.affiliation: Department of Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH.
authors.forename: C
authors.initials: C
authors.lastname: Quintini
authors.affiliation: Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Selzner
authors.affiliation: Department of Surgery, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: K
authors.initials: K
authors.lastname: Uygun
authors.affiliation: University of Cambridge Department of Surgery and the NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Watson
authors.affiliation: Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Porte
mesh_terms: D017408:Guidelines as Topic / Q000592:standards*; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D015201:Meta-Analysis as Topic; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D058028:Research Report / Q000592:standards*; D009626:Terminology as Topic; D014019:Tissue Donors
keywords: clinical research/practice; donors and donation: extended criteria; guidelines; liver transplantation/hepatology; organ perfusion and preservation