title: Highly mono-selective ortho-trifluoromethylation of benzamides via 8-aminoquinoline assisted Cu-promoted C-H activations.
abstract: A highly mono-selective ortho-trifluoromethylation of benzamides was achieved via Cu-promoted C-H activations. The reaction employs an 8-aminoquinoline group as the bidentate directing group and Togni reagent II as the CF3 source. The reaction tolerated a wide variety of functional groups and various ortho-trifluoromethylated benzamides were efficiently synthesized in 36-82% yield.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. ztanze@gmail.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Gui
authors.forename: Ze
authors.initials: Z
authors.lastname: Tan
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu