title: Dual-Functionalized Theranostic Nanocarriers.
abstract: Nanocarriers with the ability to spatially organize chemically distinct multiple bioactive moieties will have wide combinatory therapeutic and diagnostic (theranostic) applications. We have designed dual-functionalized, 100 nm to 1 μm sized scalable nanocarriers comprising a silica golf ball with amine or quaternary ammonium functional groups located in its pits and hydroxyl groups located on its nonpit surface. These functionalized golf balls selectively captured 10-40 nm charged gold nanoparticles (GNPs) into their pits. The selective capture of GNPs in the golf ball pits is visualized by scanning electron microscopy. ζ potential measurements and analytical modeling indicate that the GNP capture involves its proximity to and the electric charge on the surface of the golf balls. Potential applications of these dual-functionalized carriers include distinct attachment of multiple agents for multifunctional theranostic applications, selective scavenging, and clearance of harmful substances.
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Mo
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Preston B
authors.initials: PB
authors.lastname: Landon
authors.forename: Woraphong
authors.initials: W
authors.lastname: Janetanakit
authors.forename: Michael T
authors.initials: MT
authors.lastname: Hwang
authors.affiliation: Department of Physics, Universidad de Sonora , Hermosillo, Mexico.
authors.forename: Karla
authors.initials: K
authors.lastname: Santacruz Gomez
authors.forename: David A
authors.initials: DA
authors.lastname: Colburn
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Dossou
authors.forename: Tianyi
authors.initials: T
authors.lastname: Lu
authors.forename: Yue
authors.initials: Y
authors.lastname: Cao
authors.forename: Vrinda
authors.initials: V
authors.lastname: Sant
authors.forename: Paul L
authors.initials: PL
authors.lastname: Sud
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Akkiraju
authors.forename: Veronica I
authors.initials: VI
authors.lastname: Shubayev
authors.forename: Gennadi
authors.initials: G
authors.lastname: Glinsky
authors.forename: Ratnesh
authors.initials: R
authors.lastname: Lal
mesh_terms: D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D012822:Silicon Dioxide; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D006046:Gold; D012822:Silicon Dioxide
keywords: Janus particle; adsorption; electrostatic; gold colloid; golf ball; nanocarrier