title: Determination of normal values for an isocapnic hyperpnea endurance test in healthy individuals.
abstract: Respiratory Muscle Endurance (RME) is an alternative way to assess respiratory muscle impairment but normal values are lacking to use this test in a clinical perspective. Our objective was then to determine reference values of RME in healthy subjects. We recruited 161 healthy subjects (25-80 years old) who were distributed within 5 groups with a 10-year range. We measured vital capacity (VC) and maximal respiratory pressure (MIP, MEP). The RME test consisted of isocapnic hyperpnea at increasing levels of ventilation until exhaustion to determine Tlim (expressed in minutes and as percentage of maximal voluntary ventilation, MVV). A significant difference between age-groups was observed for both VC and MEP expressed as percentage of predicted value. Mean Tlim was 21.8±5.9min [95% confidence interval 20.9-22.8], 74.4±15.9% of predicted MVV [95% CI 71.8-76.9]. Tlim was similar among age groups. Tolerance to the RME test was excellent. This study provides normal values of RME in a large age range of healthy subjects and demonstrates that RME is preserved in the elderly.
authors.affiliation: Service de Physiologie Clinique et de l'Exercice, CHU St-Etienne, France; Laboratoire de Physiologie de l'Exercice, Université Jean Monnet, France; Service de Pneumologie et Oncologie Thoracique CHU St-Etienne, France. Electronic address: Marjolaine.Vincent@chu-st-etienne.fr.
authors.forename: Marjolaine
authors.initials: M
authors.lastname: Vincent
authors.affiliation: Service de Pneumologie et Oncologie Thoracique CHU St-Etienne, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Court-Fortune
authors.affiliation: Service de Physiologie Clinique et de l'Exercice, CHU St-Etienne, France; Service de Pneumologie et Oncologie Thoracique CHU St-Etienne, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Brun
authors.affiliation: Service de Neurologie CHU St-Etienne, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Camdessanché
authors.affiliation: Laboratoire HP2, U1042, Inserm, Université Grenoble Alpes, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: Vergès
authors.affiliation: Service de Physiologie Clinique et de l'Exercice, CHU St-Etienne, France; Laboratoire de Physiologie de l'Exercice, Université Jean Monnet, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Costes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D005080:Exercise Test / Q000009:adverse effects; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006985:Hyperventilation; D008297:Male; D000072277:Maximal Respiratory Pressures; D008875:Middle Aged; D015999:Multivariate Analysis; D018763:Muscle Fatigue; D010807:Physical Endurance; D012016:Reference Values; D012132:Respiratory Muscles / Q000502:physiology*; D014797:Vital Capacity
keywords: Exercise; Respiratory muscle; Ventilatory capacity