title: Impact of Recombinant Human Soluble Thrombomodulin for Disseminated Intravascular Coagulation.
abstract: BACKGROUND
  Early treatment of disseminated intravascular coagulation (DIC) can be associated with improved early outcomes. We aimed to evaluate the effectiveness of recombinant human soluble thrombomodulin (rTM) administration in patients with peritonitis-induced DIC.
  
  
  METHODS
  We treated 39 patients with DIC or pre-DIC caused by peritonitis at the Department of Surgery and Science, Kyushu University, and related facilities between January and December 2013.
  
  
  RESULTS
  Patients surviving to 28 days after DIC treatment had significantly better platelet counts, DIC scores, and sequential organ failure assessment scores at 7 days than did those who died earlier than 28 days. Patients receiving rTM had significantly better overall survival rates at 28 days and the results of multivariate analysis showed that rTM administration for DIC treatment was a prognostic indicator of 28-day survival in patients with peritonitis.
  
  
  CONCLUSIONS
  rTM administration for the treatment of DIC or pre-DIC complicated by peritonitis had acceptable early outcomes.
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan itoshin@surg2.med.kyushu-u.ac.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Itoh
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.affiliation: Department of Surgery, Tagawa Municipal Hospital, Tagawa, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Kohnoe
authors.affiliation: Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sadanaga
authors.affiliation: Department of Surgery, Iizuka Hospital, Iizuka, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kajiyama
authors.affiliation: Department of Surgery, Saiseikai Karatsu Hospital, Karatsu, Japan.
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Yamagata
authors.affiliation: Department of Surgery, Oita Medical Center, Oita, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Anai
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Harimoto
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Ikegami
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Yoshizumi
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000150:complications; D011379:Prognosis; D011994:Recombinant Proteins / Q000627:therapeutic use; D015996:Survival Rate; D018180:Thrombomodulin / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D018180:Thrombomodulin
keywords: Recombinant human soluble thrombomodulin; emergent surgery; gastrointestinal tract perforation