title: POLEproofreading mutation, immune response and prognosis in endometrial cancer.
abstract: Endometrial cancers (ECs) withPOLEproofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found thatPOLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome ofPOLE-mutant ECs.
authors.affiliation: Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.
authors.forename: Inge C
authors.initials: IC
authors.lastname: van Gool
authors.affiliation: Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.
authors.forename: Tjalling
authors.initials: T
authors.lastname: Bosse
authors.affiliation: Molecular and Population Genetics Laboratory, The Wellcome Trust Centre for Human Genetics, University of Oxford , Oxford, UK.
authors.forename: David N
authors.initials: DN
authors.lastname: Church
keywords: DNA polymerase ε; POLE; neopeptide; ultramutation