title: Follow-up of Women With Negative Pap Test Results and Abnormal Clinical Signs or Symptoms.
abstract: OBJECTIVE
  Abnormal signs or symptoms recorded on Papanicolaou (Pap) test requisitions may reflect disease not detected with Pap testing. Since 2009, these cases have been reviewed in our laboratory by a second cytotechnologist and a cytopathologist. The objective of this study was to document follow-up findings on these patients.
  
  
  METHODS
  A search for Pap test results of "Negative for intraepithelial lesion or malignancy, abnormal clinical signs or symptoms" was performed for cases from January 1, 2009, to October 10, 2013. Clinical information and follow-up findings were documented.
  
  
  RESULTS
  1,104 cases were identified. Signs and symptoms were abnormal bleeding 897 (81%), polyps 83 (8%), pelvic mass 54 (5%), visible cervical lesions 48 (4%), vaginal lesions 17 (2%) and endometrial masses 6 (0.5%). Six hundred sixty-seven (60%) had follow-up results, including 517 with histopathologic diagnoses. Two-hundred thirty-three (45%) had nonspecific benign diagnoses, 216 (42%) had benign tumor-like conditions, 28 (4%) had insufficient specimens, 16 (3%) had precancerous diagnoses and 23 (4%) had malignancies. Endometrial malignancy was identified in 14 (61%), ovarian in 6 (26%), and miscellaneous in 3 (13%). No cervical cancers were identified.
  
  
  CONCLUSIONS
  We report follow-up findings from patients with abnormal clinical signs or symptoms, negative Pap test results, and follow-up recommendations highlighting reported abnormal signs or symptoms. Abnormal clinical signs and symptoms should routinely be considered in assessment and management of patients with negative cervical screening test results.
authors.affiliation: From the Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, PA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ocque
authors.affiliation: From the Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, PA.
authors.forename: R Marshall
authors.initials: RM
authors.lastname: Austin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis*; D014592:Uterine Hemorrhage / Q000209:etiology; D014626:Vaginal Smears; D055815:Young Adult
keywords: Bleeding; Cervical cancer screening; Cervical lesions; Clinical signs; Cytopathology; Endometrial lesions; Gynecology; Negative Pap test; Symptoms