title: Chemometrics and the identification of counterfeit medicines-A review.
abstract: This review article provides readers with a number of actual case studies dealing with verifying the authenticity of selected medicines supported by different chemometric approaches. In particular, a general data processing workflow is discussed with the major emphasis on the most frequently selected instrumental techniques to characterize drug samples and the chemometric methods being used to explore and/or model the analytical data. However, further discussion is limited to a situation in which the collected data describes two groups of drug samples - authentic ones and counterfeits.
authors.affiliation: Institute of Chemistry, The University of Silesia, 9 Szkolna Street, 40-006 Katowice, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Krakowska
authors.affiliation: Scientific Institute of Public Health (WIV-ISP), Operational Direction Food, Medicines and Consumer Safety, Section Medicinal Products, Rue Juliette Wytmanstraat 14, B-1050 Brussels, Belgium; Research group NatuRA (Natural products and Food - Research and Analysis), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Custers
authors.affiliation: Scientific Institute of Public Health (WIV-ISP), Operational Direction Food, Medicines and Consumer Safety, Section Medicinal Products, Rue Juliette Wytmanstraat 14, B-1050 Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Deconinck
authors.affiliation: Institute of Chemistry, The University of Silesia, 9 Szkolna Street, 40-006 Katowice, Poland. Electronic address: michal.daszykowski@us.edu.pl.
authors.forename: M
authors.initials: M
authors.lastname: Daszykowski
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D016000:Cluster Analysis; D058110:Counterfeit Drugs / Q000032:analysis* / Q000737:chemistry / Q000145:classification; D016002:Discriminant Analysis; D004340:Drug Contamination / Q000517:prevention & control; D008962:Models, Theoretical; D010363:Pattern Recognition, Automated
chemical_list: D058110:Counterfeit Drugs
keywords: Classification; Data exploration; Data modeling; Discrimination; Fingerprints; Impurity profiles; Pattern recognition