title: Magnetic silica hybrids modified with guanidine containing co-polymers for drug delivery applications.
abstract: Guanidine containing co-polymers grafted onto silica nanoparticles to form core-shell structure were prepared by sol-gel method in the presence of γ-Fe2O3 nanoparticles. The morphological features for uncoated and coated silica particles have been characterized with scanning electron microscopy. The results show that the polymer coated silicas exhibit spherical morphology with rough polymeric surface covered by γ-Fe2O3 nanoparticles. The grafting amount of guanidine containing co-polymers evaluated by thermogravimetric analysis was in the range from 17 to 30%. Then, the drug loading properties and cumulative release of silica hybrids modified with guanidine containing co-polymers were evaluated using molsidomine as a model drug. It was shown that after polymer grafting the loading content of molsidomine could reach up to 3.42±0.21 and 2.34±0.14mg/g respectively. The maximum drug release of molsidomine is achieved at pH1.6 (approximately 71-75% release at 37°C), whereas at pH7.4 drug release is lower (50.4-59.6% release at 37°C). These results have an important implication that our magneto-controlled silica hybrids modified with guanidine containing co-polymers are promising as drug carriers with controlled behaviour under influence of magnetic field.
authors.affiliation: Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology (ISUCT), 7, Sheremetevsky prosp., 153000 Ivanovo, Russian Federation; RASA Сenter in Tomsk, Tomsk Polytechnic University, 30, Lenin Avenue, 634500 Tomsk, Russian Federation. Electronic address: a_timin@mail.ru.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Timin
authors.affiliation: Kabardino-Balkar State University, ul. Chernyshevskogo 173, Nal'chik, 360004 Kabardino-Balkaria, Russian Federation.
authors.forename: Svetlana Yu
authors.initials: SY
authors.lastname: Khashirova
authors.affiliation: Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology (ISUCT), 7, Sheremetevsky prosp., 153000 Ivanovo, Russian Federation.
authors.forename: Evgeniy V
authors.initials: EV
authors.lastname: Rumyantsev
authors.affiliation: Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology (ISUCT), 7, Sheremetevsky prosp., 153000 Ivanovo, Russian Federation.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Goncharenko
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry*; D060526:Magnetic Fields; D008981:Molsidomine / Q000737:chemistry / Q000493:pharmacokinetics; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide
chemical_list: D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; C000499:ferric oxide; D012822:Silicon Dioxide; D008981:Molsidomine
keywords: Core-shell structure; Drug carrier; Magnetic properties; Polymer grafting; Silica core