title: Novel Use of CF3SO2Cl for the Metal-Free Electrophilic Trifluoromethylthiolation.
abstract: The regioselective trifluoromethylthiolation of indole derivatives was achieved under reductive conditions with trifluoromethanesulfonyl chloride as the readily available source of electrophilic SCF3 and a phosphine as the reducing agent. It is a straightforward process free from any metal and also applicable for the trifluoromethylthiolation of other azaarenes, enamines, and enoxysilanes.
authors.affiliation: UMR 6014 CNRS COBRA, Normandie Université, INSA Rouen , 1 rue Tesnière, 76821 Mont Saint Aignan, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Chachignon
authors.affiliation: UMR 6014 CNRS COBRA, Normandie Université, INSA Rouen , 1 rue Tesnière, 76821 Mont Saint Aignan, France.|Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya 466-8555, Japan.
authors.forename: Mayaka
authors.initials: M
authors.lastname: Maeno
authors.affiliation: Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya 466-8555, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kondo
authors.affiliation: Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya 466-8555, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
authors.affiliation: UMR 6014 CNRS COBRA, Normandie Université, INSA Rouen , 1 rue Tesnière, 76821 Mont Saint Aignan, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Cahard