title: Reduced acute nociception and chronic pain in Shank2-/- mice.
abstract: Autism spectrum disorder is a debilitating mental illness and social issue. Autism spectrum disorder patients suffer from social isolation, cognitive deficits, compulsive behavior, and sensory deficits, including hyposensitivity to pain. However, recent studies argued that autism spectrum disorder patients show physiological pain response and, in some cases, even extremely intense pain response to harmless stimulation. Recently, Shank gene family was reported as one of the genetic risk factors of autism spectrum disorder. Thus, in this study, we used Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain.
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Ko
authors.affiliation: Department of Brain and Cognitive Sciences, College of Natural Sciences, Pain Cognitive Function Research Center, Dental Research Institute Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Seog-Bae
authors.initials: SB
authors.lastname: Oh
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, China kaang@snu.ac.kr.
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
mesh_terms: D000208:Acute Disease; D000818:Animals; D059350:Chronic Pain / Q000378:metabolism* / Q000503:physiopathology*; D008297:Male; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency* / Q000378:metabolism; D059225:Nociception; D055698:Touch Perception
chemical_list: D009419:Nerve Tissue Proteins; C488222:Shank2 protein, mouse
keywords: Autism; nociception; pain; shank2