title: Plasma sphingolipid changes with autopsy-confirmed Lewy Body or Alzheimer's pathology.
abstract: BACKGROUND
  The clinical and pathological phenotypes of Dementia with Lewy Bodies (DLB) and Alzheimer's disease (AD) often overlap. We examined whether plasma lipids differed among individuals with autopsy-confirmed Lewy Body pathology or AD pathology.
  
  
  METHODS
  We identified four groups with available plasma two years prior to death: high (n=12) and intermediate likelihood DLB (n=14) based on the third report of the DLB consortium; dementia with Alzheimer's pathology (AD; n=18); and cognitively normal with normal aging pathology (n=21). Lipids were measured using ESI/MS/MS.
  
  
  RESULTS
  There were overall group differences in plasma ceramides C16:0, C18:1, C20:0 and C24:1 and monohexosylceramides C18:1 and C24:1. These lipids did not differ between the high likelihood DLB and AD groups, but both groups had higher levels than normals. Plasma fatty acid levels did not differ by group.
  
  
  CONCLUSIONS
  Plasma ceramides and monohexosylceramides are elevated in people with dementia with either high likelihood DLB or AD pathology.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Health Sciences Research, Division of Epidemiology, Rochester, MN, 55905, USA.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Savica
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
authors.forename: Melissa E
authors.initials: ME
authors.lastname: Murray
authors.affiliation: Mayo Clinic Metabolomics Core, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Xuan-Mai
authors.initials: XM
authors.lastname: Persson
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Kejal
authors.initials: K
authors.lastname: Kantarci
authors.affiliation: Department of Pathology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Parisi
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Health Sciences Research, Division of Epidemiology, Rochester, MN, 55905, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, 32224, USA.
authors.forename: Tanis J
authors.initials: TJ
authors.lastname: Ferman
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Health Sciences Research, Division of Epidemiology, Rochester, MN, 55905, USA.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Mielke
keywords: Alzheimer’s disease; Autopsy; Ceramide; Lewy body; Lipids