title: Is there really a relationship between serum vitamin D (25OHD) levels and the musculoskeletal pain associated with statin intake? A systematic review.
abstract: BACKGROUND
  Musculoskeletal pain associated to statin use, is the most common adverse event, leading to cessation of treatment. Several studies proposed Vitamin D deficiency to increase the risk of pain associated to statin intake.
  
  
  OBJECTIVE
  To evaluate whether vitamin D status is linked to musculoskeletal pain associated to statin use.
  
  
  METHODS
  We performed a systematic review based on electronic searches through MEDLINE, Cochrane Central and EMBASE to identify studies that 1) included patients on statin therapy 2) with vitamin D serum levels assessment, 3) in relation to musculoskeletal pain.
  
  
  RESULTS
  The electronic search identified 127 potentially eligible studies, of which three were included and analysed in the present study. The heterogeneity of studies did not allow metanalysis. A systematic review and two cohort studies not included in the previous systematic review, revealed a statistically significant association of vitamin D deficit in patients with musculoskeletal pain on statin therapy.
  
  
  CONCLUSIONS
  The displayed evidence suggests a significant association between 25OHD serum levels<30ng/ml and the presence of musculoskeletal pain in patients on statin therapy.
authors.affiliation: Hospital Mediterráneo, Almería, España. Electronic address: cpereda@ser.es.
authors.forename: Claudia Alejandra
authors.initials: CA
authors.lastname: Pereda
authors.affiliation: Instituto Traumatológico Quirón, Barcelona, España.
authors.forename: Maria Betina
authors.initials: MB
authors.lastname: Nishishinya
mesh_terms: D015415:Biomarkers / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D059352:Musculoskeletal Pain / Q000139:chemically induced* / Q000209:etiology; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Dolor musculoesquelético; Estatinas; Musculoskeletal pain; Statins; Vitamin D; Vitamina D