title: [Changes and clinical significance of innate-like lymphocyte subsets in peripheral blood of patients with advanced non-small cell lung cancer].
abstract: OBJECTIVE
  To investigate the percentages and correlations of innate-like lymphocyte subsets, αβT cells and B2 cells in peripheral blood of patients with non-small cell lung cancer (NSCLC) and normal individuals.
  
  
  METHODS
  A total of 16 healthy controls, 5 NSCLC first-visit patients and 15 NSCLC stable-state patients were included to take the peripheral blood samples. Flow cytometry was performed to detect the percentages of invariant natural killer T (iNKT), γδT, B1, αβT and B2 cell subsets in peripheral blood lymphocytes.
  
  
  RESULTS
  The percentage of iNKT cells in the stable-state patients was significantly lower than that of the healthy people and first-visit patients. In addition, the percentage of αβT cells in the stable-state patients was significantly higher than that of the healthy people. The fist-visit patients had a markedly higher percentage of γδT cells than the stable-state patients, but a significantly lower percentage of B1 cells than the healthy people. There was an obviously positive correlation between iNKT cells and γδT cells in the stable-state patients. We also found a significantly positive correlation between B1 cells and B2 cells in both stable-state patients and healthy people.
  
  
  CONCLUSIONS
  The percentages of innate-like lymphocyte subsets in patients with NSCLC are in disequilibrium.
authors.affiliation: Department of Immunology, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu 233000, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wei
authors.affiliation: Department of Medical Oncology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Immunology, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu 233000, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Xia
authors.affiliation: Department of Clinical Laboratory Science, Bengbu Medical College, Bengbu 233000, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ma
authors.affiliation: Department of Immunology, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu 233000, China. *Corresponding author, E-mail: yaochunyan051@126.com.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055611:Natural Killer T-Cells / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000097:blood; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000097:blood
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta