title: Different functional connectivity and network topology in behavioral variant of frontotemporal dementia and Alzheimer's disease: an EEG study.
abstract: We investigated whether the functional connectivity and network topology in 69 Alzheimer's disease (AD), 48 behavioral variant of frontotemporal dementia (bvFTD) patients, and 64 individuals with subjective cognitive decline are different using resting-state electroencephalography recordings. Functional connectivity between all pairs of electroencephalography channels was assessed using the phase lag index (PLI). We subsequently calculated PLI-weighted networks, from which minimum spanning trees (MSTs) were constructed. Finally, we investigated the hierarchical clustering organization of the MSTs. Functional connectivity analysis showed frequency-dependent results: in the delta band, bvFTD showed highest whole-brain PLI; in the theta band, the whole-brain PLI in AD was higher than that in bvFTD; in the alpha band, AD showed lower whole-brain PLI compared with bvFTD and subjective cognitive decline. The MST results indicate that frontal networks appear to be selectively involved in bvFTD against the background of preserved global efficiency, whereas parietal and occipital loss of network organization in AD is accompanied by global efficiency loss. Our findings suggest different pathophysiological mechanisms in these 2 separate neurodegenerative disorders.
authors.affiliation: Department of Clinical Neurophysiology and MEG Center, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: m.yu@vumc.nl.
authors.forename: Meichen
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Clinical Neurophysiology and MEG Center, VU University Medical Center, Amsterdam, the Netherlands; Alzheimer Center & Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Alida A
authors.initials: AA
authors.lastname: Gouw
authors.affiliation: Department of Clinical Neurophysiology and MEG Center, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Arjan
authors.initials: A
authors.lastname: Hillebrand
authors.affiliation: Alzheimer Center & Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Betty M
authors.initials: BM
authors.lastname: Tijms
authors.affiliation: Department of Clinical Neurophysiology and MEG Center, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Cornelis Jan
authors.initials: CJ
authors.lastname: Stam
authors.affiliation: Department of Clinical Neurophysiology and MEG Center, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Elisabeth C W
authors.initials: EC
authors.lastname: van Straaten
authors.affiliation: Alzheimer Center & Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Yolande A L
authors.initials: YA
authors.lastname: Pijnenburg
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology*; D001519:Behavior / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology; D004569:Electroencephalography; D005260:Female; D057180:Frontotemporal Dementia / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009778:Occipital Lobe / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology
keywords: Alzheimer's disease; Behavioral variant of frontotemporal dementia; Electroencephalography; Functional connectivity; Network topology; Subjective cognitive decline