title: Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction.
abstract: Neutrophil extracellular traps (NETs) are part of the innate immune defense against microbes, but their contribution to several non-infectious inflammatory conditions has recently been unraveled. We demonstrate that NETs accumulate in the peripheral circulation in tumor-bearing mice, causing systemic inflammation and vascular dysfuntion in organs not affected by tumor cells.
authors.affiliation: Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Biomedical Center , Uppsala, Sweden.
authors.forename: Jessica
authors.initials: J
authors.lastname: Cedervall
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University , Rudbeck Laboratory , Uppsala, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Dimberg
authors.affiliation: Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Biomedical Center , Uppsala, Sweden.
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Olsson
keywords: Cancer; NETs; inflammation; neutrophil extracellular traps; systemic; vascular function