title: Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority.
abstract: The population genetic data and forensic parameters of 19 X-chromosome short tandem repeat (X-STR) loci in Chinese Uygur ethnic minority are presented. These loci were detected in a sample of 233 (94 males and 139 females) unrelated healthy individuals. We observed 238 alleles at the 19 X-STR loci, with the corresponding gene frequencies spanning the range from 0.0021 to 0.5644. After Bonferroni correction (P>0.0026), there were no significant deviations from Hardy-Weinberg equilibrium. The cumulative power of discrimination in females and males, and the probability of exclusion of the 19 X-STR loci were 0.999 999 999 999 999 999 998 091, 0.999 999 999 999 966, and 0.999 999 986 35, respectively. The cumulative mean exclusion chance was 0.999 999 992 849 in deficiency cases, 0.999 999 999 999 628 in normal trios, and 0.999 999 998 722 in duo cases. The high value of the forensic parameters mentioned above revealed that the novel panel of 19 loci had important values for forensic applications in the Uygur group.
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Guo
authors.affiliation: Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Chen
authors.affiliation: Criminal Police Detachment of Yili Public Security Bureau, Yili 835000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Genome Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Jiang-Wei
authors.initials: JW
authors.lastname: Yan
authors.affiliation: Key Laboratory of Genome Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of General Dentistry, Stomatological Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Tian-Hua
authors.initials: TH
authors.lastname: Yao
authors.affiliation: Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, California 92354, USA.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Hao-Tian
authors.initials: HT
authors.lastname: Meng
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Yu-Dang
authors.initials: YD
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Mei
authors.affiliation: Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Yao-Shun
authors.initials: YS
authors.lastname: Liu
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.|Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Bo-Feng
authors.initials: BF
authors.lastname: Zhu
mesh_terms: D000465:Algorithms; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D041321:Chromosomes, Human, X; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D008913:Minority Groups; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011336:Probability; D012737:Sex Factors
keywords: Forensic; Genetic polymorphism; Short tandem repeat (STR); Uygur; X-chromosome