title: A study of serum Apo A-1 and Apo B-100 levels in women with preeclampsia.
abstract: OBJECTIVE
  To investigate Apo A-1 and Apo B-100 levels and Apo B-100/Apo A-1 ratios in preeclamptic (PE) patients.
  
  
  METHODS
  Forty-eight PE and 48 without PE patients (healthy pregnancies) matched for gestational age were included. Maternal age, parity, gestational age at delivery, obstetrical complications including intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM), serum Apo A-1 and Apo B-100 levels, and the Apo B-100/Apo A-1 ratio were compared.
  
  
  RESULTS
  Preeclamptic patients had significantly lower Apo A-1 levels (167.07mg/dl±14.61mg/dl vs. 244.37mg/dl±20.84mg/dl, p<0.001), higher Apo B-100/Apo A-1 ratio (0.63±0.07 vs. 0.42±0.05, p<0.001), but similar Apo B-100 levels (104.84mg/dl±7.05mg/dl vs. 102.39mg/dl±8.08mg/dl, p=0.118). Mean Apo A-1 and Apo B-100 levels and the Apo B-100/Apo A-1 ratio were similar in patients with severe PE, HELLP syndrome, IUGR, and patients requiring antihypertensive therapy compared to PE patients who did not have these complications (p>0.05). Apo A-1 levels had the best accuracy followed by the Apo B-100/Apo A-1 ratio in patients with PE.
  
  
  CONCLUSIONS
  Apo A-1 and the Apo B-100/Apo A-1 ratio may be useful markers in patients with PE. Further studies are required to elucidate this issue.
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey. Electronic address: drhakantimur@gmail.com.
authors.forename: Hakan
authors.initials: H
authors.lastname: Timur
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey.
authors.forename: Halil Korkut
authors.initials: HK
authors.lastname: Daglar
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kara
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Kirbas
authors.affiliation: Konya Education and Research Hospital, Department of Obstetrics and Gynecology, Konya, Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Inal
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey.
authors.forename: Gulenay Gencosmanoglu
authors.initials: GG
authors.lastname: Turkmen
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Yilmaz
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Elmas
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Departmant of Perinatology Unit, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D053299:Apolipoprotein B-100 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D012680:Sensitivity and Specificity
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D015415:Biomarkers
keywords: Apo A-1; Apo B-100; Apo B-100/Apo A-1 ratio; Preeclampsia