title: Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms.
abstract: OBJECTIVE
  Epidemiological studies demonstrated that patients suffering from overactive bladder often present with different mental problems, amongst which depression is the most frequently observed. The main goal of our study was to check if the repeated administration of corticosterone (CORT) is able to evoke the depressive-like behaviour and detrusor overactivity (DO) symptoms in rats. Moreover, we investigated whether the acute administration of common antidepressants (imipramine, 30 mg/kg, and fluoxetine, 15 mg/kg), antimuscarinic (oxybutynin chloride, 0.5 mg/kg) or CRF1(SN 003, 1 mg/kg) antagonists has an impact on the cystometric parameters, behaviour in the Porsolt test, and overall locomotor activity of animals exposed to CORT.
  
  
  METHODS
  The experiments were carried out on female Wistar rats. All applied surgical and histopathology procedures, cystometric investigations, locomotor activity and forced swim measurements have been fully described in the published literature.
  
  
  RESULTS
  Fourteen-day administration of CORT may induce both depressive and DO symptoms in rats, which are reversed by the inhibition of CRF1receptors.
  
  
  CONCLUSIONS
  It seems that the CRF1receptor could be an interesting target for overactive bladder pharmacotherapy, particularly in patients with co-existing depression.
authors.affiliation: Second Department of Gynecology, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland. wrobelandrzej@yahoo.com.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wróbel
authors.affiliation: Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Serefko
authors.affiliation: Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Poleszak
authors.affiliation: Second Department of Gynecology, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Rechberger
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage; D003345:Corticosterone / Q000008:administration & dosage*; D003863:Depression / Q000150:complications; D004195:Disease Models, Animal; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage; D007099:Imipramine / Q000008:administration & dosage; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018019:Receptors, Corticotropin-Releasing Hormone / Q000008:administration & dosage; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage; D001743:Urinary Bladder / Q000473:pathology*; D053201:Urinary Bladder, Overactive / Q000139:chemically induced* / Q000150:complications; D000099052:CRF Receptor, Type 1
chemical_list: D000929:Antidepressive Agents, Tricyclic; D003345:Corticosterone; D005473:Fluoxetine; D007099:Imipramine; D018727:Muscarinic Antagonists; D018019:Receptors, Corticotropin-Releasing Hormone; D017367:Selective Serotonin Reuptake Inhibitors; D000099052:CRF Receptor, Type 1
keywords: CRF1 antagonist; Corticosterone; Depression; Overactive bladder; Rats