title: Current attempts to implement siRNA-based RNAi in leukemia models.
abstract: Leukemias arise from genetic alterations in normal hematopoietic stem or progenitor cells, leading to abnormal blood population with transformed cells. With the advent of RNAi and its pharmacological mediator siRNA, it has become possible to downregulate specific drivers causing leukemias. In this review, we present unique aspects of RNAi-mediated therapy and delivery technologies. Recent updates on molecular targets and delivery systems are discussed emanating from in vitro cell models and preclinical animal models. We conclude with a view on the future of RNAi in leukemia therapy, emphasizing possible measures to achieve higher efficacy and improved safety.
authors.affiliation: Department of Chemical & Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, Canada; Department of Biomedical Engineering, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada; Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Canada. Electronic address: hasan.uludag@ualberta.ca.
authors.forename: Hasan
authors.initials: H
authors.lastname: Uludağ
authors.affiliation: Department of Chemical & Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, Canada.
authors.forename: Breanne
authors.initials: B
authors.lastname: Landry
authors.affiliation: Department of Biomedical Engineering, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.
authors.forename: Juliana
authors.initials: J
authors.lastname: Valencia-Serna
authors.affiliation: Department of Chemical & Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, Canada.
authors.forename: K C
authors.initials: KC
authors.lastname: Remant-Bahadur
authors.affiliation: Department of Chemical & Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, Canada; Department of Biomedical Engineering, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.
authors.forename: Deniz
authors.initials: D
authors.lastname: Meneksedağ-Erol
mesh_terms: D000818:Animals; D015316:Genetic Therapy; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000628:therapy*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage*
chemical_list: D034741:RNA, Small Interfering