title: Use of interleukin-2 for management of natalizumab-associated progressive multifocal leukoencephalopathy: case report and review of literature.
abstract: A 51-year-old woman with relapsing-remitting multiple sclerosis (RRMS) and 3-year history of natalizumab use developed expressive aphasia. A brain magnetic resonance image (MRI) showed left frontotemporal and right parietal lesion with mild contrast enhancement and cerebrospinal fluid (CSF) was positive for John Cunningham virus (JCV) by polymerase chain reaction (PCR). The patient received five cycles of plasmapheresis followed by intravenous immunoglobulin. Despite this intervention, her speech deteriorated and she developed right hemiparesis. Upon referral to our institution, CSF quantitative JCV PCR was notable for 834 copies/ml. The patient was given an initial dose of 50,000 units of interleukin-2 (IL-2) subcutaneously (SQ) followed by 1 million units IL-2 SQ daily. Due to concern for immune reconstitution inflammatory syndrome (IRIS), the patient also received intravenous methylprednisone weekly. The regimen was tolerated well by the patient with no severe adverse effects. Clinically, the patient showed some improvement, and became more responsive and regained right lower extremity antigravity strength. After 12 weeks of IL-2 therapy, JCV quantitative PCR was notable for 31 copies/ml and the patient was more responsive. Due to persistence of JCV, IL-2 therapy was changed to mefloquine. At follow up after 6 months, the patient showed no clinical deterioration.
authors.affiliation: Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, Texas-75235, USA.
authors.forename: Divyanshu
authors.initials: D
authors.lastname: Dubey
authors.affiliation: Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Yinan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Graves
authors.affiliation: Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: Allen D
authors.initials: AD
authors.lastname: DeSena
authors.affiliation: Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Elliot
authors.initials: E
authors.lastname: Frohman
authors.affiliation: Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Greenberg
keywords: Immune Reconstitution Inflammatory Syndrome; Interleukin-2; Multiple sclerosis; Natalizumab; Progressive multifocal leukoencephalopathy