title: Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease.
abstract: OBJECTIVE
  To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease.
  
  
  METHODS
  A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease.
  
  
  RESULTS
  A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%.
  
  
  CONCLUSIONS
  Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.
authors.affiliation: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Marley Ribeiro
authors.initials: MR
authors.lastname: Feitosa
authors.affiliation: School of the Barão, Barão de Mauá University Center, Brazil.
authors.forename: Omar
authors.initials: O
authors.lastname: Féres Filho
authors.affiliation: São Paulo Hospital, Brazil.
authors.forename: Camila Mussolin
authors.initials: CM
authors.lastname: Tamaki
authors.affiliation: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Perazzoli
authors.affiliation: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Mário Vinícius Angelete Alvarez
authors.initials: MV
authors.lastname: Bernardes
authors.affiliation: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Rogério Serafim
authors.initials: RS
authors.lastname: Parra
authors.affiliation: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: José Joaquim Ribeiro da
authors.initials: JJ
authors.lastname: Rocha
authors.affiliation: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
authors.forename: Omar
authors.initials: O
authors.lastname: Féres
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods* / Q000706:statistics & numerical data; D007412:Intestinal Fistula / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017511:Pyoderma Gangrenosum / Q000628:therapy*; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult