title: Medication Adherence and Treatment Satisfaction Among Renal Transplant Recipients.
abstract: BACKGROUND Evidence suggests that patients who are more satisfied with their treatment show better adherence with the prescribed therapy. Although there is valuable data about medication adherence among renal transplant recipients (RTRs), there is a limited literature about their treatment satisfaction and its relation to adherence. The aim of the present study was to investigate factors that can predict medication adherence and to explore the relationship between treatment satisfaction and medication adherence in renal transplant recipients. MATERIAL AND METHODS Adult RTRs were included in the study using convenient sampling. The participants were asked to complete the 8-item Morisky Medication Adherence Scale (MMAS-8) and Treatment Satisfaction Scale TSQM 1.4 in addition to several socio-demographic and treatment-related data. The results were statistically analyzed using univariate and multivariate logistic regression modelling in a stepwise procedure. RESULTS A total of 151 RTRs were included in the study, of which 52 were classified as adherent (34%). Univariate analysis showed that, in comparison with non-adherent RTRs, the adherent group demonstrated significantly higher satisfaction scores in the domains of convenience (96.6±8.7 vs. 85.3±19.3), side effects (95.9±14.1 vs. 82.6±24.1), and global satisfaction (93.4±9.8 vs. 86.7±16.7), while they had marginally higher satisfaction scores in the effectiveness domain (90.4±11.6 vs. 86.5±14.5). Results from multiple logistic regression showed that higher likelihood of adherence was significantly associated with increased satisfaction score in the convenience domain [AOR=1.76, 95% CI=(1.21, 2.55); p=0.003] and marginally related to increased satisfaction scores in the side effects domain [AOR=1.31, 95% CI=(0.99, 1.74); p=0.061]. Male RTRs were significantly more likely to be adherent than female RTRs [AOR=2.23, 95% CI=(1.02, 4.84); p=0.043]. CONCLUSIONS Although the adherence rate among RTRs is relatively low, males and RTRs who reported higher treatment satisfaction (convenience and side effects domains) showed better medication adherence. It is recommended that interventional programs for the improvement of dialysis patient adherence should be developed, in addition to designing strategies to improve treatment convenience and knowledge of medication side effects.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Abdulmalik A
authors.initials: AA
authors.lastname: Alkatheri
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Abdulkareem M
authors.initials: AM
authors.lastname: Albekairy
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Anan
authors.initials: A
authors.lastname: Jarab
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Rami
authors.initials: R
authors.lastname: Bustami
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Nabil
authors.initials: N
authors.lastname: Khalidi
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Alshaya
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Bin Saleh
authors.affiliation: Department of Pharmaceutical Care, King Abdulaziz Medical City, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Sultan
authors.initials: S
authors.lastname: Alraddadi
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Shmeylan
authors.initials: S
authors.lastname: Alharbi
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Senthilvel
authors.initials: S
authors.lastname: Vasudevan
authors.affiliation: Nephrology Section, Department of Medicine, King Abdulaziz Medical City, Ministry National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alsayyari
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Minister National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: Amjad M
authors.initials: AM
authors.lastname: Qandil
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000523:psychology*; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D066027:Transplant Recipients / Q000523:psychology* / Q000706:statistics & numerical data; D016903:Drug Monitoring