title: The challenge of consent in clinical genome-wide testing.
abstract: Genome-wide testing methods include array comparative genomic hybridisation (aCGH), multiple gene panels, whole exome sequencing (WE) and whole genome sequencing (WGS). Here we introduce some of the key ethical and social considerations relating to informed consent for the testing of children, particularly the management of incidental findings and variants of unknown significance.
authors.affiliation: Institute of Medical Genetics, University Hospital Wales, Cardiff, UK.
authors.forename: Katherine
authors.initials: K
authors.lastname: Burke
authors.affiliation: Institute of Medical Genetics, University Hospital Wales, Cardiff, UK.
authors.forename: Angus
authors.initials: A
authors.lastname: Clarke
mesh_terms: D002648:Child; D002651:Child Advocacy / Q000941:ethics; D055106:Genome-Wide Association Study / Q000941:ethics*; D006801:Humans; D033162:Incidental Findings; D007258:Informed Consent / Q000941:ethics*; D026684:Personal Autonomy
keywords: Ethics; General Paediatrics; Genetics; Neonatology