title: In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines.
abstract: In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro.
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia.
authors.forename: Filip
authors.initials: F
authors.lastname: Grbović
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia. mstankovic@kg.ac.rs.
authors.forename: Milan S
authors.initials: MS
authors.lastname: Stanković
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Ćurčić
authors.affiliation: Department of Biomedical Sciences, State University of Novi Pazar, Vuka Karadzica, 36300 Novi Pazar, Republic of Serbia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Đorđević
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Šeklić
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia.
authors.forename: Marina
authors.initials: M
authors.lastname: Topuzović
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia.
authors.forename: Snežana
authors.initials: S
authors.lastname: Marković
keywords: HCT-116; MDA-MB-231; Origanum vulgare L.; antiproliferative activity