title: [Undifferentiated (embryonal) liver sarcoma: reviaew of 6 cases in National Cancer Institute, Lima, Peru. Review of the literature].
abstract: Undifferentiated (embryonal) liver sarcoma is a rare tumor about 2% of all malignant liver tumors with a poor prognosis and usually occurs in children, this review aims to assess cases of primary embryonal sarcoma of the liver presented at our institution the past 8 years and improve recognition of its variants and evaluate immunohistochemical characteristics that help differentiated it from other tumors. Six cases of undifferentiated liver sarcoma were histologically evaluated and investigated by immunohistochemistry with a panel of antibodies using the equipment â€œAutostainer Link 48â€. Usually masses were on average more than 20 cm, with solid, cystic, mucinous areas. The microscopic features include cells of spindle cell appearance, oval, starry, epithelioid and multinucleated cells densely arranged in a myxoid matrix. Trapped bile ducts and hepatic cords often present in the periphery of tumors. Intracellular and extracellular PAS positive hyaline globules. Immunohistochemistry showed very divergent differentiation.
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Daniela
authors.initials: D
authors.lastname: Dueñas
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Huanca
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Mónica
authors.initials: M
authors.lastname: Cordero
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Patricia
authors.initials: P
authors.lastname: Webb
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Eloy
authors.initials: E
authors.lastname: Ruiz
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010568:Peru; D012509:Sarcoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor