title: Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia.
abstract: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by small benign tumors of mesenchymal origin also known as phosphaturic mesenchymal tumors mixed connective tissue variant. Excellent prognosis is expected with eradication of the culprit tumor. These small tumors are notoriously difficult to localize with conventional imaging studies; this often leads to an extensive work up and prolonged morbidity. We report a patient with clinical diagnosis of TIO whose culprit tumor was localized with Ga-68 DOTATOC PET/CT and MRI. Biopsy and cryoablation were performed under Ga-68 DOTATOC PET/CT guidance. Autoradiography of the biopsy specimen was performed and showed in situ correlation between Ga-68 DOTATOC uptake and histopathology with millimeter resolution.
authors.affiliation: Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, M276C, New York, NY, 10065, USA. maybodym@mskcc.org.
authors.forename: Majid
authors.initials: M
authors.lastname: Maybody
authors.affiliation: Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Ravinder K
authors.initials: RK
authors.lastname: Grewal
authors.affiliation: Orthopedic Surgical Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Healey
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Cristina R
authors.initials: CR
authors.lastname: Antonescu
authors.affiliation: Department of Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Louise
authors.initials: L
authors.lastname: Fanchon
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Sinchun
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Carrasquillo
authors.affiliation: Department of Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Assen
authors.initials: A
authors.lastname: Kirov
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Azeez
authors.initials: A
authors.lastname: Farooki
mesh_terms: D001345:Autoradiography / Q000379:methods*; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000473:pathology* / Q000601:surgery*; D015282:Octreotide / Q000031:analogs & derivatives*; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D016896:Treatment Outcome
chemical_list: D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D015282:Octreotide; C106246:Edotreotide
keywords: Cryoablation; DOTATOC PET/CT; Osteomalacia; Tumor-induced