title: Hitchhiker's Guide to Voxel Segmentation for Partial Volume Correction of In Vivo Magnetic Resonance Spectroscopy.
abstract: Partial volume effects have the potential to cause inaccuracies when quantifying metabolites using proton magnetic resonance spectroscopy (MRS). In order to correct for cerebrospinal fluid content, a spectroscopic voxel needs to be segmented according to different tissue contents. This article aims to detail how automated partial volume segmentation can be undertaken and provides a software framework for researchers to develop their own tools. While many studies have detailed the impact of partial volume correction on proton magnetic resonance spectroscopy quantification, there is a paucity of literature explaining how voxel segmentation can be achieved using freely available neuroimaging packages.
authors.affiliation: Faculty of Health, School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia; Faculty of Health and Medicine, School of Health Sciences, The University of Newcastle, Callaghan, NSW, Australia; Translational Research Institute, Woolloongabba, QLD, Australia.
authors.forename: Scott
authors.initials: S
authors.lastname: Quadrelli
authors.affiliation: Translational Research Institute, Woolloongabba, QLD, Australia.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Mountford
authors.affiliation: Faculty of Health and Medicine, School of Health Sciences, The University of Newcastle, Callaghan, NSW, Australia.
authors.forename: Saadallah
authors.initials: S
authors.lastname: Ramadan
keywords: magnetic resonance spectroscopy; neurospectroscopy; partial volume; quantification; segmentation