title: [Not Available].
abstract: (68)Gallium (Ga)-PSMA PET/CT (PSMA stands for "prostate-specific membrane antigen") is a new diagnostic tool for patients with prostate cancer or with prostate cancer metastases. PET/CT is a combination scan which uses the physiological information of the PET scan and the anatomic information of the CT scan. The radioligand (68)Ga-PSMA is a radioactively labelled peptide that binds to the membrane protein PSMA. Prostate cancer cells in the primary tumour and in metastases express increased levels of PSMA in the plasma membrane. A number of studies have shown that (68)Ga-PSMA PET/CT is sensitive in detecting primary prostate cancer and metastases in lymph nodes and bone. In the same patient, (68)Ga-PSMA PET/CT detects more metastases in an earlier phase, i.e. at a lower PSA level, than fluorine-18 choline PET/CT. Furthermore, the (68)Ga-PSMA can be produced in the investigating hospital with a gallium generator. The expectation is that the use of (68)Ga-PSMA PET/CT will increase to a major extent over the coming years in patients with prostate cancer.
authors.affiliation: Namens de Nederlandse werkgroep 68Ga-PSMA-PET-diagnostiek bij prostaatcarcinoom.
authors.forename: Jules
authors.initials: J
authors.lastname: Lavalaye
authors.forename: Marnix G E H
authors.initials: MG
authors.lastname: Lam
authors.forename: J F Fred
authors.initials: JF
authors.lastname: Verzijlbergen
authors.forename: Gerard C
authors.initials: GC
authors.lastname: Krijger
authors.forename: Roeland
authors.initials: R
authors.lastname: Vis
authors.forename: Bart
authors.initials: B
authors.lastname: de Keizer
mesh_terms: D000954:Antigens, Surface; D002794:Choline; D004492:Edetic Acid / Q000031:analogs & derivatives; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009842:Oligopeptides; D049268:Positron-Emission Tomography / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D000954:Antigens, Surface; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; D002794:Choline