title: The potential of intravenous immunoglobulins for cancer therapy: a road that is worth taking?
abstract: Much has been learned recently about the role of immunoglobulins as effector molecules of the adaptive immunity and as active elements in the maintenance of immune homeostasis. The increasing number of pathologies where intravenous immunoglobulins (IVIg) display a beneficial action illustrates their therapeutic relevance. Considering recent findings on the ability of IVIg to modulate macrophage polarization, herein we review evidences on the antitumoral activity of IVIg. Fragmentary and nonconclusive, available evidences are just suggestive of the potential of IVIg in antitumoral therapy, but encourage for the generation of additional evidences through well-designed clinical trials, and for additional studies to address the molecular effects of IVIg as a means to avoid the extrapolation of data gathered from animal models.
authors.affiliation: Centro de Investigaciones Biológicas, CSIC. Ramiro de Maeztu, 9. 28040 Madrid, SPAIN.
authors.forename: Angel L
authors.initials: AL
authors.lastname: Corbí
authors.affiliation: Department of Clinical Immunology & IdISSC, Hospital Clínico San Carlos, Prof Martín Lagos, S/N, 28040 Madrid, Spain; and, Department of Microbiology I, Complutense University School of Medicine, Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Sánchez-Ramón
authors.affiliation: Centro de Investigaciones Biológicas, CSIC. Ramiro de Maeztu, 9. 28040 Madrid, SPAIN.
authors.forename: Angeles
authors.initials: A
authors.lastname: Domínguez-Soto
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods*; D008264:Macrophages / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D057170:Translational Research, Biomedical
chemical_list: D016207:Cytokines; D016756:Immunoglobulins, Intravenous
keywords: cancer therapy; intravenous immunoglobulins; macrophages