title: Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb.
abstract: Four new dianthrone glycosides, named polygonumnolides C1-C4 (1-4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5-6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1-4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 μM, respectively.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.|b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.|c School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Dai
authors.affiliation: b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
authors.forename: Xing-Chao
authors.initials: XC
authors.lastname: Geng
authors.affiliation: b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.|c School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Shuang-Cheng
authors.initials: SC
authors.lastname: Ma
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Ya-Lun
authors.initials: YL
authors.lastname: Su
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004642:Emodin / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D028502:Polygonum / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000873:Anthracenes; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D004642:Emodin
keywords: L-02 cell lines; Polygonum multiflorum; dianthrone glycosides; polygonumnolides C1–C4