title: Sepantronium bromide (YM155) improves daratumumab-mediated cellular lysis of multiple myeloma cells by abrogation of bone marrow stromal cell-induced resistance.
authors.affiliation: Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, the Netherlands.
authors.forename: Sanne J
authors.initials: SJ
authors.lastname: de Haart
authors.affiliation: Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Lisa
authors.initials: L
authors.lastname: Holthof
authors.affiliation: Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Willy A
authors.initials: WA
authors.lastname: Noort
authors.affiliation: Department of Hematology, University Medical Center Utrecht, the Netherlands.
authors.forename: Monique C
authors.initials: MC
authors.lastname: Minnema
authors.affiliation: Department of Hematology, University Medical Center Utrecht, the Netherlands.
authors.forename: Maarten E
authors.initials: ME
authors.lastname: Emmelot
authors.affiliation: Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, the Netherlands.
authors.forename: Tineke
authors.initials: T
authors.lastname: Aarts-Riemens
authors.affiliation: Janssen Research & Development, Spring House, PA, USA.
authors.forename: Parul
authors.initials: P
authors.lastname: Doshi
authors.affiliation: Janssen Research & Development, Spring House, PA, USA.
authors.forename: Kate
authors.initials: K
authors.lastname: Sasser
authors.affiliation: Xpand Biotechnology BV, Bilthoven, the Netherlands.
authors.forename: Huipin
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Xpand Biotechnology BV, Bilthoven, the Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: de Bruijn
authors.affiliation: Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Anton C M
authors.initials: AC
authors.lastname: Martens
authors.affiliation: Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Niels W C J
authors.initials: NW
authors.lastname: van de Donk
authors.affiliation: Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Henk M
authors.initials: HM
authors.lastname: Lokhorst
authors.affiliation: Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Richard W J
authors.initials: RW
authors.lastname: Groen
authors.affiliation: Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, the Netherlands Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands t.mutis@vumc.nl.
authors.forename: Tuna
authors.initials: T
authors.lastname: Mutis
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D001854:Bone Marrow Cells / Q000502:physiology; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology; D009285:Naphthoquinones / Q000494:pharmacology / Q000627:therapeutic use*; D017154:Stromal Cells; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D007093:Imidazoles; D009285:Naphthoquinones; C556306:daratumumab; C523798:sepantronium
keywords: abrogation; bone marrow stromal cell; cell lysis; deratumumab; multiple myeloma; sepantronium bromide