title: [Glutamate lonotropic Receptors: Structure, Localisation, Function].
abstract: The data on the structure, location and function of ionotropic glutamate receptors is shown. These include NMDA-, AMPA-, kainate and orphan receptor, activation them ensures the formation of an action potential. The ionotropic receptors are present in the CNS and peripheral organs. There are a large number of them allosteric modulators, agonists and antagonists. NMDA- and AMPA-receptors play a key role in the origin and manifestation of long-term potentiation. When NMDA- and AMPA-receptors are hyperactivity excitotoxicity arises--a pathological process that causes damage and death of neurons. The ionotropic glutamate receptors are involved in the regulation of mental functions, respiratory, sensory, cardiovascular, nociceptive, etc. g. systems.
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
mesh_terms: D000200:Action Potentials / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D059225:Nociception / Q000502:physiology; D017933:Peripheral Nervous System / Q000166:cytology / Q000502:physiology*; D021122:Protein Subunits / Q000737:chemistry / Q000502:physiology*; D018091:Receptors, AMPA / Q000737:chemistry / Q000502:physiology*; D018092:Kainic Acid Receptors / Q000737:chemistry / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry / Q000502:physiology*; D012119:Respiration
chemical_list: D021122:Protein Subunits; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate