title: Lobulated margination of liver hemangiomas: Is this a definitive feature?
abstract: OBJECTIVE
  To evaluate the occurrence rate of lobulated margination of hepatic hemangiomas.
  
  
  METHODS
  The study population included 585 hemangiomas in 261 patients (161 females; mean age: 51.9years). Two readers independently reviewed all cases.
  
  
  RESULTS
  Hemangiomas with lobulated margins accounted for 74.7% of all lesions. The incidence of lobulated margins was significantly higher (P<.001) in medium- and large-sized hemangiomas (77.6% and 99.5%, respectively). The majority of hemangiomas with type-3 enhancement showed lobulated margins (83.5%) (P<.001).
  
  
  CONCLUSIONS
  Virtually, all hemangiomas>18mm show lobulated margins. The majority of hemangiomas with type-3 enhancement show lobulated margins. Lack of lobulated margins in larger lesions lowers the likelihood ratio for being hemangiomas.
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, NC, USA; Department of Radiology, Hospital Garcia de Orta, Almada, Portugal. Electronic address: antoniopmatos@gmail.com.
authors.forename: António P
authors.initials: AP
authors.lastname: Matos
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, NC, USA. Electronic address: radiologyjeon@gmail.com.
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Jeon
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, NC, USA; Department of Radiology, Hospital Garcia de Orta, Almada, Portugal. Electronic address: miguel-ramalho@netcabo.pt.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ramalho
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, NC, USA; Department of Radiology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. Electronic address: hwyd@yahoo.com.
authors.forename: Mamdoh
authors.initials: M
authors.lastname: AlObaidy
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, NC, USA. Electronic address: richsem@med.unc.edu.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Semelka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006391:Hemangioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007089:Image Enhancement; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D000072662:Margins of Excision; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine
keywords: Lobulated margination; MRI; contour; liver hemangioma; size