title: Reprogramming for Cardiac Regeneration-Strategies for Innovation.
abstract: It is well-known that the human myocardium has a low capacity for self-regeneration. This fact is especially important after acute myocardial infarction with subsequent heart failure and adverse tissue remodeling. New potential strategies have recently emerged for treating heart diseases, such as the possibility of generating large quantities of cardiomyocytes through genetic iPSC reprogramming, transdifferentiation for in vitro disease modeling, in vivo therapies or telomerase gene reactivation. Approaches based on these techniques may represent the new horizon in cardiology with an appropriate 180-degree turn perspective. J. Cell. Physiol. 231: 1849-1851, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Research Institute Hospital 12 de Octubre ("i + 12"), Madrid, Spain.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.affiliation: Facultad de Medicina, Departamento de Bioquímica, Instituto de Investigaciones Biomédicas "Alberto Sols," (UAM-CSIC) and Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Galera
authors.affiliation: Research Institute Hospital 12 de Octubre ("i + 12"), Madrid, Spain.|European University of Madrid, Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
authors.affiliation: Research Institute Hospital 12 de Octubre ("i + 12"), Madrid, Spain.|Facultad de Medicina, Departamento de Bioquímica, Instituto de Investigaciones Biomédicas "Alberto Sols," (UAM-CSIC) and Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain.
authors.forename: María Esther
authors.initials: ME
authors.lastname: Gallardo
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D054338:Cell Transdifferentiation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D009203:Myocardial Infarction / Q000628:therapy*; D009206:Myocardium / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000502:physiology; D012038:Regeneration / Q000502:physiology*