title: Diagnostics and Therapy for Malignant (Degenerate) Colon Endometriosis - Three Case Reports.
abstract: Malignant degeneration of colon endometriosis is a very rare event. We report here on three cases. A 48-year-old woman with a 10-year history of endometriosis was treated for a rectal adenocarcinoma, a 61-year-old G1P1, who was operated at the age of 40 years for ovarian endometriosis and again at the age of 53 years for an endometriosis-associated endometroid ovarian carcinoma, presented for therapy for a lymph node recurrence of the ovarian cancer and, secondly, due to a malignantly degenerated rectum-sigmoid colon endometriosis; furthermore a 54-year old woman with a 21-year history of endometriosis was operated for malignant colon endometriosis. The tumour occurred during an adjuvant anti-oestrogen treatment with an aromatase inhibitor following surgical and radiotherapy for breast cancer. In all cases a radical cancer operation was followed by adjuvant chemotherapy and in one case with an additional radiotherapy. In the follow-up periods of 18 months, 2 and 5 years, respectively, all women remained free of recurrences. Although this is not a randomised controlled study due to the rare occurrence of such cases, a radical operation followed by individualised adjuvant therapy appears to be the treatment of choice.
authors.affiliation: Endometriosezentrum Ammerland, Frauenklinik, Ammerland-Klinik GmbH, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Hannover, Westerstede.
authors.forename: R
authors.initials: R
authors.lastname: Schutz
authors.affiliation: Pathologisches Institut Aurich/Westerstede, Westerstede.
authors.forename: J
authors.initials: J
authors.lastname: Woziwodzki
authors.affiliation: Endometriosezentrum Ammerland, Frauenklinik, Ammerland-Klinik GmbH, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Hannover, Westerstede.
authors.forename: K-W
authors.initials: KW
authors.lastname: Schweppe
keywords: bowel endometriosis; endometriosis-associated carcinoma; malignant degeneration