title: [Oligometastasized stage IV colorectal cancer : Surgical resection and local ablative procedures].
abstract: BACKGROUND
  By the intensified combination of systemic, surgical and local ablative therapies a significant improvement in therapy results for metastasized colorectal cancer has been achieved in the last decade. Downstaging with subsequent resection is nowadays a standard for oligometastasized primarily unresectable colorectal cancer.
  
  
  METHODS
  The value of combining resection and local ablation is unclear; therefore, this article gives an overview of the available literature dealing with the combination of surgery and local ablative methods for oligometastasized stage IV colorectal cancer.
  
  
  RESULTS
  The best results were obtained following surgical resection alone. Whereas nowadays cryoablation is of minor importance, the most successful results are achieved following local ablative methods by radiofrequency and microwave ablation. In the future irreversible electroporation will be the most promising local ablative method. A combination of surgical resection and local ablation appears to be rational in patients if an R0 resection can be achieved.
  
  
  CONCLUSIONS
  Surgical resection of colorectal liver metastases is the gold standard for oncological therapy whenever possible. The rational combination of non-curative surgical resection and local ablation should be considered in the context of a multimodal therapeutic strategy, particularly in patients with primarily resectable disease.
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Binnebösel
authors.affiliation: Klinik für Diagnostische und Interventionelle Radiologie, Uniklinik der RWTH Aachen, Aachen, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Bruners
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
authors.forename: C D
authors.initials: CD
authors.lastname: Klink
authors.affiliation: Klinik für Diagnostische und Interventionelle Radiologie, Uniklinik der RWTH Aachen, Aachen, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Kuhl
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland. uneumann@ukaachen.de.
authors.forename: U P
authors.initials: UP
authors.lastname: Neumann
mesh_terms: D055011:Ablation Techniques; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D003131:Combined Modality Therapy; D018450:Disease Progression; D006801:Humans; D059146:Metastasectomy; D009367:Neoplasm Staging
keywords: Colon cancer; Liver metastases; Microwave ablation; Radiofrequence ablation; Surgery