title: Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers.
abstract: A new, simple, and fast electrochemical (EC) method has been developed to determine the release profile of piroxicam, a nonsteroidal anti-inflammatory drug, loaded in a drug delivery system based on nanostructured lipid carriers (NLCs). For the first time, the samples were analyzed by using square wave voltammetry, a sensitive EC technique. The piroxicam EC responses allow us to propose a model that explains the experimental results and to subsequently determine the amount of drug loaded into the NLCs formulation as a function of time. In vitro drug release studies showed prolonged drug release (up to 5 days), releasing 60 % of the incorporated drug. The proposed method is a promising and stable alternative for the study of different drug delivery systems.
authors.affiliation: Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal # 3, C.P. X5804BYA, Río Cuarto, Argentina), Fax: (+54) 358-4676233.
authors.forename: Jessica
authors.initials: J
authors.lastname: Otarola
authors.affiliation: Departamento de Química, Universidad Nacional del Sur, INQUISUR (UNS-CONICET), Avenida Alem 1253, 8000, Bahia Blanca, Argentina.
authors.forename: Mariano
authors.initials: M
authors.lastname: Garrido
authors.affiliation: Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal # 3, C.P. X5804BYA, Río Cuarto, Argentina), Fax: (+54) 358-4676233.
authors.forename: N Mariano
authors.initials: NM
authors.lastname: Correa
authors.affiliation: Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal # 3, C.P. X5804BYA, Río Cuarto, Argentina), Fax: (+54) 358-4676233. pmolina@exa.unrc.edu.ar.
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Molina
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D065546:Drug Liberation; D055664:Electrochemical Techniques / Q000379:methods*; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D010894:Piroxicam / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D008055:Lipids; D010894:Piroxicam
keywords: electrochemistry; nanostructured lipid carriers; piroxicam; release profiles; square wave voltammetry