title: GPER-novel membrane oestrogen receptor.
abstract: The recent discovery of the G protein-coupled oestrogen receptor (GPER) presents new challenges and opportunities for understanding the physiology, pathophysiology and pharmacology of many diseases. This review will focus on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target.
authors.affiliation: Department of Pharmacology, Tulane University, New Orleans, LA, U.S.A.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Zimmerman
authors.affiliation: Department of Pharmacology, Tulane University, New Orleans, LA, U.S.A.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Budish
authors.affiliation: Department of Pharmacology, Tulane University, New Orleans, LA, U.S.A.
authors.forename: Shreya
authors.initials: S
authors.lastname: Kashyap
authors.affiliation: Department of Pharmacology, Tulane University, New Orleans, LA, U.S.A. lindsey@tulane.edu.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Lindsey
mesh_terms: D000818:Animals; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D004967:Estrogens; C109584:GPER1 protein, human; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled
keywords: GPR30; cancer; cardiovascular; menopause; metabolism; reproduction