title: Cardiovascular Toxicity and Management of Targeted Cancer Therapy.
abstract: The advent of effective oral, molecular-targeted drugs in oncology has changed many incurable malignancies such as chronic myeloid leukemia into chronic diseases similar to coronary artery disease and diabetes mellitus. Oral agents including monoclonal antibodies, kinase inhibitors and hormone receptor blockers offer patients with cancer incremental improvements in both overall survival and quality of life. As it is imperative to recognize and manage side effects of platelet inhibitors, beta blockers, statins, human immunodeficiency virus drugs and fluoroquinolones by all healthcare providers, the same holds true for these newer targeted therapies; patients may present to their generalist or other subspecialist with drug-related symptoms. Cardiovascular adverse events are among the most frequent, and potentially serious, health issues in outpatient clinics, and among the most frequent side effects of targeted chemotherapy. Data support improved patient outcomes and satisfaction when primary care and other providers are cognizant of chemotherapy side effects, allowing for earlier intervention and reduction in morbidity and healthcare costs. With the implementation of accountable care and pay for performance, improved communication between generalists and subspecialists is essential to deliver cost-effective patient care.
authors.affiliation: Gatton College of Pharmacy, East Tennessee State University, Johnson City, Tennessee.
authors.forename: John B
authors.initials: JB
authors.lastname: Bossaer
authors.affiliation: Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Geraci
authors.affiliation: Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee. Electronic address: chakrabk@etsu.edu.
authors.forename: Kanishka
authors.initials: K
authors.lastname: Chakraborty
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D002319:Cardiovascular System / Q000187:drug effects*; D019468:Disease Management; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer therapy; Oral therapy; Outcomes; Toxicities and side effects