title: Epigenetic changes in diabetes.
abstract: The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the leading causes of death. Diabetes is a genetic disease; however, the environment plays critical roles in its development and progression. Epigenetic changes often translate environmental stimuli to changes in gene expression. Changes in epigenetic marks and differential regulation of epigenetic modulators have been observed in different models of diabetes and its associated complications. In this minireview, we will focus DNA methylation, Histone acetylation and methylation and their roles in the pathogenesis of diabetes.
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Rami
authors.initials: R
authors.lastname: Al-Haddad
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Nabil
authors.initials: N
authors.lastname: Karnib
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Rawad Abi
authors.initials: RA
authors.lastname: Assaad
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Yara
authors.initials: Y
authors.lastname: Bilen
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Nancy
authors.initials: N
authors.lastname: Emmanuel
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ghanem
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Joe
authors.initials: J
authors.lastname: Younes
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Victor
authors.initials: V
authors.lastname: Zibara
authors.affiliation: School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Stephan
authors.affiliation: Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon. Electronic address: sama.sleiman01@lau.edu.lb.
authors.forename: Sama F
authors.initials: SF
authors.lastname: Sleiman
mesh_terms: D000818:Animals; D019175:DNA Methylation; D003920:Diabetes Mellitus / Q000235:genetics*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D042421:Histone Code; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: D022661:RNA, Untranslated
keywords: DNA methylation; Diabetes; Epigenetics; HDACs