title: [Zika virus, an emerging threat].
abstract: Zika virus, discovered in 1947, is particularly publicized because of its involvement in a major epidemic that began in 2015 and which epicenter is located in Latin America, mainly in Brazil. In the majority of cases (70-80 %) the infection is asymptomatic, however in some patients, moderate fever, skin rash, conjunctivitis and myalgia may occur. More alarming, neurological complications are reported, in particular cases of microcephaly probably resulting from the infection of women in the first or second trimester of pregnancy. Moreover, Guillain-Barré syndromes have also been identified in patients whose infection was confirmed. The extent of the current outbreak reveals the very primitive state of knowledge about the pathophysiology of this virus. Thus, a global effort is being undertaken in order to quickly characterize the molecular interaction of the virus with human cells, but also to develop specific diagnostic assays and vaccinal approaches.
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France.
authors.forename: Sara
authors.initials: S
authors.lastname: Salinas
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Centre hospitalier universitaire de Montpellier, département de bactériologie-virologie, Montpellier, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Foulongne
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Loustalot
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Établissement français du sang, parc Euromédecine, 34184 Montpellier Cedex 4, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Fournier-Wirth
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Molès
authors.affiliation: CPBS, FRE3689, CNRS-université de Montpellier, 1919, route de Mende, 34293 Montpellier Cedex 5, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Briant
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Centre hospitalier universitaire de Montpellier, département de bactériologie-virologie, Montpellier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Nagot
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Centre hospitalier universitaire de Montpellier, département de bactériologie-virologie, Montpellier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Van de Perre
authors.affiliation: UMR 1058, Inserm/université de Montpellier/Établissement français du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Université de Montpellier, 4, boulevard Henri IV, 34967 Montpellier Cedex 2, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Simonin
mesh_terms: D001938:Brazil / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000706:statistics & numerical data; D058872:Epidemics; D005260:Female; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000821:virology; D000071244:Zika Virus / Q000502:physiology*; D000071243:Zika Virus Infection / Q000453:epidemiology*