title: Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition.
abstract: Endothelial to mesenchymal transition (EndMT) is a poorly understood phenomenon that results in normal endothelial cells acquiring a mesenchymal phenotype. EndMT has been observed in a number of pathological conditions, from cancer to fibrosis to cardiovascular disease and the process itself may play an important mechanistic role in the development of these disease states.
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Chen
authors.affiliation: Yale Cardiovascular Research Center, 300 George St New Haven, CT 06511, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Simons
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology*; D042783:Endothelial Cells / Q000166:cytology*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction