title: Congenital Malformations Leading to Paradoxical Embolism.
abstract: The absolute separation of the right and left circulations and the filtration of blood by the pulmonary circulation are essential to prevent the passage of thrombotic material from the venous system into the systemic arterial circulation. Any breach of the intracardiac septae or circumvention of the pulmonary capillary network may cause a paradoxical embolus. The most common causes are atrial septal defects and pulmonary arteriovenous malformations. This article discusses unusual connections and pathways related to congenital malformations. Although anticoagulation is necessary to prevent paradoxical emboli, the hematologic disturbances and the most appropriate therapy in these patients warrant further investigation.
authors.affiliation: Cardiac Catheterization, Section of Pediatric Cardiology, Schneider Children's Medical Center Israel, Kaplan 14, Petach Tikva 42902, Israel. Electronic address: elchananb@bezeqint.net.
authors.forename: Elchanan
authors.initials: E
authors.lastname: Bruckheimer
mesh_terms: D000013:Congenital Abnormalities / Q000453:epidemiology*; D019320:Embolism, Paradoxical / Q000453:epidemiology / Q000209:etiology*; D014943:Global Health; D006801:Humans; D015994:Incidence; D012307:Risk Factors
keywords: Congenital defects; Cyanosis; Paradoxical embolism; Shunt