title: Computational design of protein self-assembly.
abstract: Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries. Here, we discuss some of the underlying biophysical principles of self-assembly that influence the design problem and highlight methodological advances that have made self-assembly design a fruitful area of protein design.
authors.affiliation: Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
authors.forename: Christoffer H
authors.initials: CH
authors.lastname: Norn
authors.affiliation: Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden. Electronic address: Ingemar.andre@biochemistry.lu.se.
authors.forename: Ingemar
authors.initials: I
authors.lastname: André
mesh_terms: D019295:Computational Biology / Q000379:methods*; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins