title: Early-onset Atrial Fibrillation in Brothers with a Huge Left Atrial Appendage.
abstract: Having a relative with atrial fibrillation (AF) is one of the risk factors for AF development, especially in young patients, which is known as familial AF. Although familial AF is considered to be associated with inherited factors, its genetic and pathophysiological backgrounds have not been fully identified. We report two young brothers undergoing radiofrequency catheter ablation for AF, who had a huge left atrial appendage (LAA). In both cases, the origins of the main triggers of the AF were not the huge LAA itself, but left pulmonary veins compressed by the LAA. Since catheter ablation including pulmonary vein isolation, the sinus rhythm has been maintained in both patients.
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan.
authors.forename: Tetsuma
authors.initials: T
authors.lastname: Kawaji
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shizuta
authors.forename: Takeru
authors.initials: T
authors.lastname: Makiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000328:Adult; D020517:Atrial Appendage / Q000000981:diagnostic imaging* / Q000473:pathology; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics / Q000601:surgery; D017115:Catheter Ablation / Q000379:methods; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D011667:Pulmonary Veins / Q000000981:diagnostic imaging / Q000601:surgery; D011668:Pulmonary Veno-Occlusive Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D035781:Siblings; D014057:Tomography, X-Ray Computed