title: High mobility group box1 protein is involved in acute inflammation induced by Clostridium difficile toxin A.
abstract: High mobility group box1 (HMGB1), as a damage-associated inflammatory factor, contributes to the pathogenesis of numerous chronic inflammatory and autoimmune diseases. In this study, we explored the role of HMGB1 in CDI (Clostridium difficile infection) by in vivo and in vitro experiments. Our results showed that HMGB1 might play an important role in the acute inflammatory responses to C. difficile toxin A (TcdA), affect early inflammatory factors, and induce inflammation via the HMGB1-TLR4 pathway. Our study provides the essential information for better understanding the molecular mechanisms of CDI and the potential new therapeutic strategies for the treatment of this infection.
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China.
authors.forename: Bei-Lei
authors.initials: BL
authors.lastname: Zhang
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China.
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Sun
authors.affiliation: Shenzhen Huada Gene Research Institute, Shenzhen 518083, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China Guangdong Province Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510006, China lishan@scut.edu.cn jufwang@scut.edu.cn.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China lishan@scut.edu.cn jufwang@scut.edu.cn.
authors.forename: Ju-Fang
authors.initials: JF
authors.lastname: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001427:Bacterial Toxins / Q000633:toxicity*; D002460:Cell Line; D004195:Disease Models, Animal; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004768:Enterotoxins / Q000633:toxicity*; D005260:Female; D019695:Glycyrrhizic Acid / Q000494:pharmacology; D024243:HMGB1 Protein / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D051379:Mice; D000067996:RAW 264.7 Cells; D051197:Toll-Like Receptor 4 / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D001427:Bacterial Toxins; D004768:Enterotoxins; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; C582808:HMGB1 protein, mouse; D018836:Inflammation Mediators; C495345:TLR4 protein, human; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; C041348:tcdA protein, Clostridium difficile; D019695:Glycyrrhizic Acid
keywords: Clostridium difficile toxin A; HMGB1; ileal loop; inflammation