title: Management of Hypogonadism in Cardiovascular Patients: What Are the Implications of Testosterone Therapy on Cardiovascular Morbidity?
abstract: Testosterone replacement therapy is recommended for men with clinical androgen deficiency with decades of evidence supporting its use for treatment of sexual, physical, and psychological consequences of male hypogonadism. In this updated review, the authors discuss the implications of testosterone deficiency and conflicting evidence regarding testosterone replacement therapy and its effects on the cardiovascular system. Based on mounting evidence, the authors conclude that testosterone therapy can be safely considered in men with appropriately diagnosed clinical androgen deficiency and concurrent cardiovascular risk factors and even manifest cardiovascular disease after a thorough discussion of potential risks and with guideline-recommended safety monitoring.
authors.affiliation: Division of Cardiology, New York University School of Medicine, 462 First Avenue, NBV 17 South, New York, NY 10016, USA.
authors.forename: Monique S
authors.initials: MS
authors.lastname: Tanna
authors.affiliation: Division of Cardiology, New York University School of Medicine, New York, NY, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Schwartzbard
authors.affiliation: Division of Cardiology, New York University School of Medicine, New York, NY, USA.
authors.forename: Jeffery S
authors.initials: JS
authors.lastname: Berger
authors.affiliation: Division of Cardiology, New York University School of Medicine, New York, NY, USA.
authors.forename: James
authors.initials: J
authors.lastname: Underberg
authors.affiliation: Division of Cardiology, New York University School of Medicine, New York, NY, USA.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Gianos
authors.affiliation: Division of Cardiology, New York University School of Medicine, New York, NY, USA. Electronic address: howard.weintraub@nyumc.org.
authors.forename: Howard S
authors.initials: HS
authors.lastname: Weintraub
mesh_terms: D002318:Cardiovascular Diseases / Q000139:chemically induced; D002319:Cardiovascular System / Q000187:drug effects; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D008297:Male; D009017:Morbidity; D013739:Testosterone / Q000009:adverse effects / Q000172:deficiency / Q000627:therapeutic use*
chemical_list: D013739:Testosterone
keywords: Androgen deficiency; Androgens; Cardiovascular risk; Hypogonadism; Mortality; Testosterone