title: Potassium Dichromate Toxicities: Protective Effect of Methanol Extract of Corchorus olitorius in Albino Rats.
abstract: Exposure to hexavalent chromate compounds such as other human carcinogens is unavoidable in the developing countries of the world. Research efforts are being directed toward minimizing exposure to them, intercepting their activity in vivo, and/or prophylaxis. The present study therefore evaluates the effect of methanol extract of the leafy vegetable, Corchorus olitorius (MECO), against potassium dichromate (K2Cr2O7)-induced toxicities. Negative control animals were fed distilled water, while the positive control rats received 12 mg/kg body weight K2Cr2O7 once a week for 6 weeks. Test rats were exposed daily to 25, 50, and 100 mg/kg body weight MECO alone for 6 weeks and 12 mg/kg body weight of K2Cr2O7 once a week for 6 weeks before sacrifice. The frequency of micronucleated polychromatic erythrocytes (mPCEs) was monitored in bone marrow cells, while induction of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine levels, and hematological parameters were assessed in the plasma. The phytochemical analysis of MECO was also carried out. K2Cr2O7 significantly (P < .05) increased the levels of mPCEs, AST, ALT, creatinine, total white blood cells, and lymphocytes compared with the control. The percentage pack cell volume and neutrophils were, however, reduced. In contrast, MECO at different doses restored the markers toward the levels of the negative control. MECO is rich in flavonoids, saponins, anthraquinones, terpenoids, and phenols, and they might be responsible for the protective effect observed in this study. Our results suggest that MECO has a promising potential in the treatment/management of chromate-induced toxicities.
authors.affiliation: 1 Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, University of Ibadan , Ibadan, Nigeria .|2 Department of Chemical Sciences, Bells University of Technology , Ota, Nigeria .
authors.forename: Kazeem A
authors.initials: KA
authors.lastname: Akinwumi
authors.affiliation: 3 Department of Sciences Laboratory Technology, Moshood Abiola Polytechnic , Abeokuta, Nigeria .
authors.forename: Olabode O
authors.initials: OO
authors.lastname: Osifeso
authors.affiliation: 4 Department of Veterinary Pathology, University of Ibadan , Ibadan, Nigeria .
authors.forename: Afusat J
authors.initials: AJ
authors.lastname: Jubril
authors.affiliation: 5 Department of Public Health, City University of New York , New York, USA.
authors.forename: Ayobami W
authors.initials: AW
authors.lastname: Adedoja
authors.affiliation: 2 Department of Chemical Sciences, Bells University of Technology , Ota, Nigeria .
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Ogunbiyi
authors.affiliation: 3 Department of Sciences Laboratory Technology, Moshood Abiola Polytechnic , Abeokuta, Nigeria .
authors.forename: Fumilayo M
authors.initials: FM
authors.lastname: Adebo
authors.affiliation: 3 Department of Sciences Laboratory Technology, Moshood Abiola Polytechnic , Abeokuta, Nigeria .
authors.forename: Idayat O
authors.initials: IO
authors.lastname: Adesina
authors.affiliation: 1 Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, University of Ibadan , Ibadan, Nigeria .
authors.forename: Oyeronke A
authors.initials: OA
authors.lastname: Odunola
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D032381:Corchorus / Q000737:chemistry*; D003404:Creatinine / Q000097:blood; D005419:Flavonoids / Q000008:administration & dosage / Q000032:analysis; D000075322:Heavy Metal Poisoning; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000097:blood; D018384:Oxidative Stress; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D011041:Poisoning / Q000097:blood / Q000188:drug therapy*; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005419:Flavonoids; D019216:Metals, Heavy; D010936:Plant Extracts; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011192:Potassium Dichromate
keywords: creatinine; haematological parameters; hepatoprotection; hexavalent chromate; liver function markers; micronucleus; urea