title: Airway damage of prematurity: The impact of prolonged intubation, ventilation, and chronic lung disease.
abstract: Over the past four decades, advances in neonatal intensive care have led to the survival of smaller and more immature infants. The improved survival of very low birth weight infants is associated with long term respiratory morbidity, most frequently in the form of bronchopulmonary dysplasia. In this review, we will discuss the pathogenesis, risk factor as well as management of commonly seen acquired airway disorders associated with prematurity, prolonged intubation and ventilation.
authors.affiliation: The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: zhang@email.chop.edu.
authors.forename: Huayan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology, Beijing Children's Hospital, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pulmonary Medicine, Beijing Children's Hospital, Beijing, China.
authors.forename: Shunying
authors.initials: S
authors.lastname: Zhao
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal; D007440:Intubation / Q000009:adverse effects*; D012121:Respiration, Artificial / Q000009:adverse effects*
keywords: Bronchopulmonary dysplasia; Gestational age; Positive end expiratory pressure; Positive pressure ventilation; Tracheobronchomalacia; Very low birth weight