title: Vitamin D Pathway Gene Polymorphisms and Keratinocyte Cancers: A Nested Case-Control Study and Meta-Analysis.
abstract: BACKGROUND
  The vitamin D endocrine system is implicated in skin carcinogenesis and polymorphisms in genes associated with the vitamin D receptor (VDR) gene may alter the risk of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)).
  
  
  METHODS
  In a nested case-control study of 1,124 adults, we investigated associations between polymorphisms in VDR-related pathways and incident keratinocyte cancers during 11 years of follow-up using adjusted multivariate regression analysis. We also performed a meta-analysis of rs2228570, rs7975232, rs1544410 and rs739837 polymorphisms.
  
  
  RESULTS
  A total of 286 BCCs and 161 SCCs were newly-diagnosed during follow-up. Participants with rs2228570 and rs927650 recessive genotypes had a decreased risk of SCC (odds ratio (OR)=0.34, 95% confidence interval (CI)=0.17-0.68; OR=0.48, CI=0.27-0.84, respectively). Meta-analysis showed a lower SCC risk in rs1544410 recessive genotypes (summary OR (SOR)=0.74, CI=0.53-0.94), while rs7975232 and rs739837 recessive genotypes were associated with a decreased BCC risk (SOR=0.74, CI=0.56-0.98; SOR=0.65, CI=0.43-0.88).
  
  
  CONCLUSIONS
  Our meta-analysis indicated that vitamin D receptor polymorphisms may be associated with the risk of keratinocyte cancers.
authors.affiliation: The University of Queensland, School of Public Health, Herston, Australia QIMR Berghofer Medical Research Institute, Herston, Australia.
authors.forename: Lena A
authors.initials: LA
authors.lastname: VON Schuckmann
authors.affiliation: QIMR Berghofer Medical Research Institute, Herston, Australia.
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Law
authors.affiliation: QIMR Berghofer Medical Research Institute, Herston, Australia.
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
authors.affiliation: QIMR Berghofer Medical Research Institute, Herston, Australia CRUK Manchester Institute and Institute of Inflammation and Repair, University of Manchester, Manchester, U.K.
authors.forename: Adele C
authors.initials: AC
authors.lastname: Green
authors.affiliation: The University of Queensland, School of Public Health, Herston, Australia QIMR Berghofer Medical Research Institute, Herston, Australia j.vanderpols@uq.edu.au.
authors.forename: Jolieke C
authors.initials: JC
authors.lastname: VAN DER Pols
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol
keywords: Vitamin D pathway; basal cell carcinoma; keratinocyte cancers; polymorphisms; squamous cell carcinoma