title: PD-1 Shapes B Cells as Evildoers in the Tumor Microenvironment.
abstract: Protumorigenic PD-1(hi) B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti-PD-1 or anti-PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells. Cancer Discov; 6(5); 477-8. ©2016 AACRSee related article by Xiao et al., p. 546.
authors.affiliation: Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Peng
authors.affiliation: Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas. Yang-Xin.Fu@UTSouthwestern.edu.
authors.forename: Yang-Xin
authors.initials: YX
authors.lastname: Fu
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism; D060890:B7-H1 Antigen / Q000276:immunology*; D006801:Humans; D008113:Liver Neoplasms; D061026:Programmed Cell Death 1 Receptor / Q000037:antagonists & inhibitors; D013601:T-Lymphocytes / Q000276:immunology; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D060890:B7-H1 Antigen; D061026:Programmed Cell Death 1 Receptor