title: Purinergic Signaling During Immune Cell Trafficking.
abstract: Migration and positioning of immune cells is fundamental for their differentiation and recruitment at sites of infection. Besides the fundamental role played by chemokines and their receptors, recent studies demonstrate that a complex network of purinergic signaling events plays a key role in these trafficking events. This process includes the release of nucleotides (such as ATP and ADP) and subsequent autocrine and paracrine signaling events through nucleotide receptors. At the same time, surface-expressed ectoapyrases and nucleotidases convert extracellular nucleotides to adenosine, and adenosine signaling events play additional functional roles in leucocyte trafficking. In this review we revisit classical paradigms of inflammatory cell trafficking in the context of recent studies implicating purinergic signaling events in this process.
authors.affiliation: Department of Life Science and Biotechnology, University of Ferrara, I-44100 Ferrara, Italy. Electronic address: davide.ferrari@unife.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Ferrari
authors.affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
authors.forename: Eóin N
authors.initials: EN
authors.lastname: McNamee
authors.affiliation: Department of Pulmonary Medicine, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Idzko
authors.affiliation: Department of Life Science and Biotechnology, University of Ferrara, I-44100 Ferrara, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
authors.forename: Holger K
authors.initials: HK
authors.lastname: Eltzschig
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001081:Apyrase / Q000378:metabolism; D002450:Cell Communication; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007962:Leukocytes / Q000502:physiology*; D008213:Lymphocyte Activation; D009708:Nucleotidases / Q000378:metabolism; D011983:Receptors, Purinergic / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018925:Chemokines; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate; D009708:Nucleotidases; D001081:Apyrase; D000241:Adenosine
keywords: P1 receptors; P2 receptors; chemokine receptors; chemokines