title: Early Bone Formation at a Femur Defect Using CGF and PRF Grafts in Adult Dogs: A Comparative Study.
abstract: OBJECTIVE
  The purpose of this study was to compare the predictability of new bone formation using an autologous concentrated growth factor (CGF) graft alone and platelet graft alone.
  
  
  METHODS
  Four bony defects of 8 mm were formed, and 3.7- × 10-mm implants were placed in the right femur. The platelet-rich fibrin (PRF), CGF, and synthetic bone were grafted to the bone defect area. Enzyme linked immunosorbent assay quantitative analysis and microscopic analysis of the fibrinogen structure were performed.
  
  
  RESULTS
  At 4 weeks, the comparisons of each experimental group showed a significant difference between the CGF group and the synthetic bone graft group. When comparing the CGF and allograft material groups, the allograft group showed significantly more new bone formation. In the case of vascular endothelial growth factor, CGF had 1.5 times more than PRF. CGF showed a fibrinogen structure with a constant diameter.
  
  
  CONCLUSIONS
  When applied to a clinical case, CGF is predicted to show better results than PRF.
authors.affiliation: *Resident, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Republic of Korea. †Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Republic of Korea. ‡Associate Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Republic of Korea. §Assistant Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Republic of Korea. ¶Assistant Professor, Department of Pre-Dentistry, School of Dentistry, Chosun University, Gwangju, Republic of Korea. ‖Professor, Department of Pathology, School of Medicine, Chosun University, Gwangju, Republic of Korea. #Professor, Department of Dental Hygiene, Kangwon National University, Samcheok, Republic of Korea. ††Clinical doctor, Misomore Dental Clinic, Jeonju, Republic of Korea.
authors.forename: Hyun-Chun
authors.initials: HC
authors.lastname: Park
authors.forename: Su-Gwan
authors.initials: SG
authors.lastname: Kim
authors.forename: Ji-Su
authors.initials: JS
authors.lastname: Oh
authors.forename: Jae-Seek
authors.initials: JS
authors.lastname: You
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Sung-Chul
authors.initials: SC
authors.lastname: Lim
authors.forename: Mi-Ae
authors.initials: MA
authors.lastname: Jeong
authors.forename: Jin-Son
authors.initials: JS
authors.lastname: Kim
authors.forename: Chan
authors.initials: C
authors.lastname: Jung
authors.forename: Young-Sun
authors.initials: YS
authors.lastname: Kwon
authors.forename: Hyeok
authors.initials: H
authors.lastname: Ji
mesh_terms: D000818:Animals; D001792:Blood Platelets; D016025:Bone Transplantation / Q000379:methods*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D005269:Femur / Q000254:growth & development / Q000601:surgery; D005337:Fibrin / Q000627:therapeutic use*; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D005337:Fibrin