title: Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction.
abstract: Acute myocardial infarction (AMI) is frequently associated with transient hyperglycemia even in patients without pre-existing diabetes. Acute stress can lead to increased blood glucose through the effect of catecholamines on alpha2A-adrenergic receptors (α2A-ARs) present in pancreatic islet β-cells. Variation in the gene (ADRA2A) that encodes the α2A-AR affects insulin release and glucose control and may play a particularly important role during times of stress.
  
  
  
  We performed a retrospective cohort study using de-identified electronic medical records linked to a DNA repository in 521 Caucasians and 55 African-American non-diabetic patients with AMI. We examined the association between admission blood glucose concentrations and ten selected ADRA2A SNPs in Caucasians.
  
  
  
  Three ADRA2A SNPS were associated with stress-induced hyperglycemia in Caucasians. Individuals homozygous for the rs10885122 variant (n=9) had a 23% lower admission glucose (geometric mean [95% CI], 99 [83-118]mg/dl) compared with non-carriers (121 [118-125] mg/dl; n=401; P=0.001). Admission glucose was 14% higher in rs1800544 variant homozygotes (134 [119-150]mg/dl; n=36) compared to non-carriers (118 [115-121]mg/dl; n=290, P=0.046). Furthermore, homozygotes of the rs553668 variant (n=13) had a 13% higher glucose (133 [110-160]mg/dl) compared to non-carriers (118 [115-122]mg/dl; n=366; P=0.056). Haplotypes including these ADRA2A SNPs were associated with higher admission glucose levels.
  
  
  
  Three ADRA2A genetic variants are associated with blood glucose and stress-induced hyperglycemia after AMI in Caucasians.
authors.affiliation: Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Abiodun
authors.initials: A
authors.lastname: Adefurin
authors.affiliation: Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Vanderbilt
authors.affiliation: Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Chimalum
authors.initials: C
authors.lastname: Okafor
authors.affiliation: Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Vivian
authors.initials: V
authors.lastname: Kawai
authors.affiliation: Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, United States.
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
authors.forename: Anushi
authors.initials: A
authors.lastname: Shah
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: Wei
authors.affiliation: Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA; Clinical Pharmacology Unit, Rambam Medical Center, Haifa, Israel; Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel. Electronic address: daniel.kurnik@vanderbilt.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kurnik
authors.affiliation: Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: C Michael
authors.initials: CM
authors.lastname: Stein
mesh_terms: D001741:Black or African American / Q000235:genetics; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012189:Retrospective Studies; D013315:Stress, Psychological / Q000097:blood / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: C547768:ADRA2A protein, human; D018341:Receptors, Adrenergic, alpha-2
keywords: Alpha adrenergic receptors; Glucose; Stress