title: Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals.
abstract: Intracellular Ca2+ signal plays a major role in many cellular processes, such as apoptosis and epithelial to mesenchymal transition (EMT). The role of Ca2+ in apoptotic signaling has been investigated deeply over the past few decades. In recent years, it has made progress in the interactions of intracellular Ca2+ homeostasis with EMT. Besides, Bcl-2 family proteins as versatile regulators of cell apoptosis not only regulate Ca2+ signal, but also play an important role in the induction of EMT. In this review, we summarized the relations among intracellular Ca2+ concentration, apoptosis and Bcl-2 family proteins. We also discussed the functions of intracellular Ca2+ concentration and Bcl-2 family proteins in EMT. By taking into account these analyses; we proposed a hypothesis of cell death and survival controlled by calcium signal.
authors.forename: Yanjiao
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400044, China. tangliling@cqu.edu.cn.
authors.forename: Liling
authors.initials: L
authors.lastname: Tang
mesh_terms: D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D002118:Calcium