title: Is there a relationship between slow coronary flow and normal to mildly impaired renal function?
abstract: OBJECTIVE
  The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is more effective at estimating glomerular filtration rate (GFR) than the Modification of Diet in Renal Disease (MDRD) equation, particularly in patients with mildly impaired renal function. Recent studies have demonstrated, using the Cockroft-Gault and MDRD formulas, a significant correlation between slow coronary flow (SCF) and normal to mildly impaired renal function. However, these studies had some limitations. The aim of the present study was to investigate the relationship between SCF and normal to mildly impaired renal function using the CKD-EPI equation.
  
  
  METHODS
  A total of 370 patients were included, 172 with normal coronary flow (NCF) and 198 with SCF. All participants had normal to mildly impaired renal function. Both the CKD-EPI and MDRD formulas were used to calculated estimated glomerular filtration rate (eGFR), which was compared between groups.
  
  
  RESULTS
  No significant difference in mean values of eGFR was found between the NCF and SCF groups (CKD-EPI: 92.9±14.7 vs 92.7±14.2, p=0.72; MDRD: 89.5±19.5 vs 88.2±17.0, p=0.70, respectively). Among patients with eGFR(MDRD) ≥90 mL/min/1.73 m2, mean eGFR levels were lower among patients with SCF (107.0±12.7 vs 102.7±10.0, p=0.02).
  
  
  CONCLUSIONS
  No correlation was found between SCF and normal to mildly impaired renal function.
authors.affiliation: Department of Cardiology, Tepecik Training and Research Hospital, İzmir, Turkey. kardio.80@hotmail.com.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Çabuk
authors.affiliation: Department of Cardiology, Buca Seyfi Demirsoy State Hospital, İzmir, Turkey.
authors.forename: Gizem
authors.initials: G
authors.lastname: Çabuk
authors.affiliation: Department of Cardiology, Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Karamanlıoğlu
authors.affiliation: Department of Cardiology, Besni State Hospital, Adıyaman, Turkey.
authors.forename: Kader
authors.initials: K
authors.lastname: Eliz Uzel
authors.affiliation: Department of Cardiology, Sincan State Hospital, Ankara, Turkey.
authors.forename: Sezen
authors.initials: S
authors.lastname: Bağlan Uzunget
authors.affiliation: Department of Cardiology, Kuşadası State Hospital, Aydın, Turkey.
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Aslantürk
authors.affiliation: Department of Cardiology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Güray
mesh_terms: D000328:Adult; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000503:physiopathology*; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000453:epidemiology*; D012189:Retrospective Studies
chemical_list: D003404:Creatinine