title: Genotype Adjusts Fibrotic Phenotype to Drive Pancreatic Cancer.
abstract: Mutant SMAD4 PDAC increases tumor cell tension to modulate fibrosis and increase malignancy.
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D005355:Fibrosis; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006801:Humans; D051379:Mice; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D015398:Signal Transduction