title: Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients.
abstract: Patients with Alzheimer's disease (AD) experience a wide array of cognitive deficits, which typically include the impairment of explicit memory. In previous studies, the authors reported that a flavonoid, quercetin, reduces the expression of ATF4 and delays memory deterioration in an early-stage AD mouse model. In the present study, the effects of long-term quercetin intake on memory recall were assessed using contextual fear conditioning in aged wild-type mice. In addition, the present study examined whether memory recall was affected by the intake of quercetin-rich onion (a new cultivar of hybrid onion 'Quergold') powder in early-stage AD patients. In-vivo analysis indicated that memory recall was enhanced in aged mice fed a quercetin-containing diet. Memory recall in early-stage AD patients, determined using the Revised Hasegawa Dementia Scale, was significantly improved by the intake of quercetin-rich onion (Quergold) powder for 4 weeks compared with the intake of control onion ('Mashiro' white onion) powder. These results indicate that quercetin might influence memory recall.
authors.affiliation: Departments of aNeurobiology bNeurology and Geriatrics cPharmacy, Gifu University Graduate School of Medicine dLong Term Care Health Facility Senjyu Nagomino eChikaishi Clinic fAsahi University, Gifu gHokkaido Agricultural Research Center, National Agriculture and Food Research Organization (NARO) hHokkaido Research Organization, Sapporo iRIKEN Center for Sustainable Resource Science, Yokohama jNational Food Research Institute, NARO, Tsukuba, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Itoh
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ohta
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Miki
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akanabe
authors.forename: Tokio
authors.initials: T
authors.lastname: Chikaishi
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Itoh
authors.forename: Takato
authors.initials: T
authors.lastname: Muro
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yanagida
authors.forename: Ryo
authors.initials: R
authors.lastname: Nakabayashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.forename: Kazuki
authors.initials: K
authors.lastname: Saito
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohzawa
authors.forename: Chihiro
authors.initials: C
authors.lastname: Suzuki
authors.forename: Shimo
authors.initials: S
authors.lastname: Li
authors.forename: Masashi
authors.initials: M
authors.lastname: Ueda
authors.forename: Miao-Xing
authors.initials: MX
authors.lastname: Wang
authors.forename: Emika
authors.initials: E
authors.lastname: Nishida
authors.forename: Saiful
authors.initials: S
authors.lastname: Islam
authors.lastname: Tana
authors.forename: Masuko
authors.initials: M
authors.lastname: Kobori
authors.forename: Takashi
authors.initials: T
authors.lastname: Inuzuka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging; D000814:Aniline Compounds; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D052160:Benzothiazoles / Q000493:pharmacokinetics; D003213:Conditioning, Psychological / Q000187:drug effects*; D005239:Fear / Q000187:drug effects*; D005260:Female; D006801:Humans; D020367:Iofetamine / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D011939:Mental Recall / Q000187:drug effects; D000073216:Mental Status and Dementia Tests; D051379:Mice; D008810:Mice, Inbred C57BL; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011794:Quercetin / Q000627:therapeutic use*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D000975:Antioxidants; D052160:Benzothiazoles; D013844:Thiazoles; D011794:Quercetin; D020367:Iofetamine