title: Comparison of 2 commercial single-dose Mycoplasma hyopneumoniae vaccines and porcine reproductive and respiratory syndrome virus (PRRSV) vaccines on pigs dually infected with M. hyopneumoniae and PRRSV.
abstract: The objective of this study was to compare the efficacy of 2 different commercial Mycoplasma hyopneumoniae vaccines and porcine reproductive and respiratory syndrome virus (PRRSV) vaccines in regard to growth performance, microbiological and immunological analyses, and pathological observation from wean to finish (175 d of age). Pigs were administered M. hyopneumoniae and PRRSV vaccines at 7 and 21 d of age, respectively, or both at 21 d old and then challenged with both M. hyopneumoniae and PRRSV at 49 d old. Significant (P < 0.05) differences were observed between the 2 vaccinated challenged groups in average daily weight gain, nasal shedding of M. hyopneumoniae, M. hyopneumoniae-specific interferon-γ secreting cells, and macroscopic and microscopic lung lesions. Induction of interleukin-10 following PRRSV vaccination does not interfere with the immune responses induced by M. hyopneumoniae vaccine. The present study demonstrated that the single-dose vaccination regimen for M. hyopneumoniae and PRRSV vaccine is efficacious for controlling coinfection with M. hyopneumoniae and PRRSV based on clinical, microbiological, immunological, and pathological evaluation.
authors.affiliation: Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
authors.forename: Changhoon
authors.initials: C
authors.lastname: Park
authors.affiliation: Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
authors.forename: Ikjae
authors.initials: I
authors.lastname: Kang
authors.affiliation: Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
authors.forename: Hwi Won
authors.initials: HW
authors.lastname: Seo
authors.affiliation: Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
authors.forename: Jiwoon
authors.initials: J
authors.lastname: Jeong
authors.affiliation: Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
authors.forename: Kyuhyung
authors.initials: K
authors.lastname: Choi
authors.affiliation: Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
authors.forename: Chanhee
authors.initials: C
authors.lastname: Chae
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D004269:DNA, Bacterial / Q000302:isolation & purification; D009175:Mycoplasma Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D045705:Mycoplasma hyopneumoniae / Q000276:immunology*; D019318:Porcine Reproductive and Respiratory Syndrome / Q000517:prevention & control*; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology*; D012367:RNA, Viral / Q000302:isolation & purification; D013552:Swine; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D004269:DNA, Bacterial; D012367:RNA, Viral; D014765:Viral Vaccines