title: Prednisone lowers serum uric acid levels in patients with decompensated heart failure by increasing renal uric acid clearance.
abstract: Clinical studies have shown that large doses of prednisone could lower serum uric acid (SUA) in patients with decompensated heart failure (HF); however, the optimal dose of prednisone and underlying mechanisms are unknown. Thirty-eight patients with decompensated HF were randomized to receive standard HF care alone (n = 10) or with low-dose (15 mg/day, n = 8), medium-dose (30 mg/day, n = 10), or high-dose prednisone (60 mg/day, n = 10), for 10 days. At the end of the study, only high-dose prednisone significantly reduced SUA, whereas low- and medium-dose prednisone and standard HF care had no effect on SUA. The reduction in SUA in high-dose prednisone groups was associated with a significant increase in renal uric acid clearance. In conclusion, prednisone can reduce SUA levels by increasing renal uric acid clearance in patients with decompensated HF.
authors.affiliation: a Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.|b Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: b Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China.
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Zhen
authors.affiliation: b Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China.
authors.forename: Qingzhen
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: b Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China.
authors.forename: Jian-Long
authors.initials: JL
authors.lastname: Zhai
authors.affiliation: b Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China.
authors.forename: Kunshen
authors.initials: K
authors.lastname: Liu
authors.affiliation: a Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.|c 361 East Zhongshan Road, Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Zhang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D011241:Prednisone / Q000494:pharmacology / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood* / Q000652:urine*
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D014527:Uric Acid; D011241:Prednisone
keywords: acide urique; clairance rénale de l’acide urique; heart failure; insuffisance cardiaque; prednisone; renal uric acid clearance; uric acid