title: Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG).
abstract: OBJECTIVE
  To develop a large-scale real clinical database of glaucoma (Japanese Archive of Multicentral Databases in Glaucoma: JAMDIG) and to investigate the effect of treatment.
  
  
  METHODS
  The study included a total of 1348 eyes of 805 primary open-angle glaucoma patients with 10 visual fields (VFs) measured with 24-2 or 30-2 Humphrey Field Analyzer (HFA) and intraocular pressure (IOP) records in 10 institutes in Japan. Those with 10 reliable VFs were further identified (638 eyes of 417 patients). Mean total deviation (mTD) of the 52 test points in the 24-2 HFA VF was calculated, and the relationship between mTD progression rate and seven variables (age, mTD of baseline VF, average IOP, standard deviation (SD) of IOP, previous argon/selective laser trabeculoplasties (ALT/SLT), previous trabeculectomy, and previous trabeculotomy) was analyzed.
  
  
  RESULTS
  The mTD in the initial VF was -6.9 ± 6.2 dB and the mTD progression rate was -0.26 ± 0.46 dB/year. Mean IOP during the follow-up period was 13.5 ± 2.2 mm Hg. Age and SD of IOP were related to mTD progression rate. However, in eyes with average IOP below 15 and also 13 mm Hg, only age and baseline VF mTD were related to mTD progression rate.
  
  
  CONCLUSIONS
  Age and the degree of VF damage were related to future progression. Average IOP was not related to the progression rate; however, fluctuation of IOP was associated with faster progression, although this was not the case when average IOP was below 15 mm Hg.
authors.affiliation: Department of Ophthalmology The University of Tokyo, Tokyo, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Fujino
authors.affiliation: Department of Ophthalmology The University of Tokyo, Tokyo, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Asaoka
authors.affiliation: Department of Ophthalmology The University of Tokyo, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Murata
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Atsuya
authors.initials: A
authors.lastname: Miki
authors.affiliation: Department of Ophthalmology, Shimane University Faculty of Medicine, Shimane, Japan 4Division of Ophthalmology, Matsue Red Cross Hospital, Shimane, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tanito
authors.affiliation: Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Mizoue
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Mori
authors.affiliation: Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Department of Ophthalmology, University of Yamanashi Faculty of Medicine, Yamanashi, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashiwagi
authors.affiliation: Orthoptics and Visual Science, Department of Rehabilitation, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shoji
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D005901:Glaucoma / Q000473:pathology* / Q000601:surgery; D005902:Glaucoma, Open-Angle / Q000473:pathology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D014130:Trabeculectomy; D016896:Treatment Outcome; D055815:Young Adult