title: Pharmacological modulation of pulvinar resting-state regional oscillations and network dynamics in major depression.
abstract: The pulvinar, the largest thalamus nucleus, has rich anatomical connections with several different cortical and subcortical regions suggesting its important involvement in high-level cognitive and emotional functions. Unfortunately, pulvinar dysfunction in psychiatric disorders particularly major depression disorder has not been thoroughly examined to date. In this study we explored the alterations in the baseline regional and network activities of the pulvinar in MDD by applying spectral analysis of resting-state oscillatory activity, functional connectivity and directed (effective) connectivity on resting-state fMRI data acquired from 20 healthy controls and 19 participants with MDD. Furthermore, we tested how pharmacological treatment with duloxetine can modulate the measured local and network variables in ten participants who completed treatment. Our results revealed a frequency-band dependent modulation of power spectrum characteristics of pulvinar regional oscillatory activity. At the network level, we found MDD is associated with aberrant causal interactions between pulvinar and several systems including default-mode and posterior insular networks. It was also shown that duloxetine treatment can correct or overcompensate the pathologic network behavior of the pulvinar. In conclusion, we suggest that pulvinar regional baseline oscillatory activity and its resting-state network dynamics are compromised in MDD and can be modulated therapeutically by pharmacological treatment.
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: rtadayon@psych.uic.edu.
authors.forename: Reza
authors.initials: R
authors.lastname: Tadayonnejad
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Olusola
authors.initials: O
authors.lastname: Ajilore
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Mickey
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Natania A
authors.initials: NA
authors.lastname: Crane
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Hsu
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Jon-Kar
authors.initials: JK
authors.lastname: Zubieta
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Langenecker
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D000068736:Duloxetine Hydrochloride / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020649:Pulvinar / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D012146:Rest / Q000502:physiology
chemical_list: D000928:Antidepressive Agents; D000068736:Duloxetine Hydrochloride