title: Orexin-A level elevation in recently abstinent male methamphetamine abusers.
abstract: Research has suggested that methamphetamine (METH) use influences orexin regulation. We examined the difference in orexin-A levels between METH abusers and healthy controls. Fasting serum orexin-A levels were measured in 35 participants who used METH in the preceding 3 weeks and 36 healthy controls. We found METH abusers had significantly higher orexin-A levels. No association was observed between orexin-A levels and METH use variables. Our results, consistent with prior preclinical evidence, showed that recent METH exposure is associated with increased orexin-A expression. Further investigation is required to determine whether orexin-A levels normalize after a longer term of abstinence.
authors.affiliation: Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
authors.forename: Wen-Yin
authors.initials: WY
authors.lastname: Chen
authors.affiliation: Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Chung-Feng
authors.initials: CF
authors.lastname: Kao
authors.affiliation: Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
authors.forename: Po-Yu
authors.initials: PY
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Shih-Ku
authors.initials: SK
authors.lastname: Lin
authors.affiliation: Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: mch@tpech.gov.tw.
authors.forename: Ming-Chyi
authors.initials: MC
authors.lastname: Huang
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects; D000068797:Orexins / Q000097:blood*; D013375:Substance Withdrawal Syndrome / Q000097:blood* / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D000068797:Orexins; D008694:Methamphetamine
keywords: Human; Methamphetamine; Orexin