title: Carrot (Daucus carota L.): Nephroprotective against gentamicin-induced nephrotoxicity in rats.
abstract: OBJECTIVE
  Daucus carota L.(DC) commonly known as carrot, folkorically used as ethnomedicine to treat nephrosis and other urinary disorders. Hence, the present study was aimed to investigate the nephroprotective effects of ethanolic root extract of DC against gentamicin-induced nephrotoxicity in Albino Wistar rats.
  
  
  METHODS
  Nephrotoxicity in rats was induced by intraperitoneal administration of gentamicin (100 mg/kg/day) for 8 days. Rats of either sex were divided into four groups (n = 6). Group 1 served as control that received normal saline (i.p.) whereas Group 2 (GM) was treated with gentamicin which served as gentamicin-intoxicated group. Group 3-4 (DC200, DC 400) were pretreated with DC at doses of 200 mg/kg and 400 mg/kg (p.o.), respectively, 1 h before the gentamicin intoxication. Following treatment, the nephroprotective effects of DC were evaluated by using serum levels of urea, blood urea nitrogen (BUN), uric acid, and creatinine levels; change in body weight and wet kidney weight along with the histological observations among the experimental groups.
  
  
  RESULTS
  Gentamicin intoxication induced elevated serum urea, BUN, uric acid, and creatinine levels which was found to be significantly (P < 0.01) decreased in a dose-dependent manner in groups received DC which was also evidenced by the histological observations.
  
  
  CONCLUSIONS
  DC showed a significant nephroprotective effect in a dose-dependent manner by ameliorating the gentamicin-induced nephrotoxicity and thus authenticates its ethnomedicinal use.
authors.affiliation: Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, Tirupathi, Andhra Pradesh, India.
authors.forename: Vamsi
authors.initials: V
authors.lastname: Sodimbaku
authors.affiliation: Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, Tirupathi, Andhra Pradesh, India.
authors.forename: Latha
authors.initials: L
authors.lastname: Pujari
authors.affiliation: Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, Tirupathi, Andhra Pradesh, India.
authors.forename: Raviteja
authors.initials: R
authors.lastname: Mullangi
authors.affiliation: Department of Pharmacology, Gitam University, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Saisudheer
authors.initials: S
authors.lastname: Marri
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D018552:Daucus carota / Q000737:chemistry*; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010936:Plant Extracts
keywords: Carrot; ethnomedicine; gentamicin; nephroprotective; nephrosis