title: NSimScan: DNA comparison tool with increased speed, sensitivity and accuracy.
abstract: Nucleotide Similarity Scanner (NSimScan) is specialized for searching massive DNA databases for distant similarities. Its targeted applications include phylogenomics, comparative and functional studies of non-coding sequences, contamination detection, etc. NSimScan outperforms industry standard tools in combined sensitivity, accuracy and speed, operating at sensitivity similar to BLAST, accuracy of ssearch and speed of MegaBLAST.
  
  
  
  NSimScan is available at https://github.com/abadona/qsimscan as a part of QSimScan package. It is implemented in C ++, distributed under MIT license and supported on Linux, OS X and Windows (with cygwin).
  
  
  
  dkaznadzey@yahoo.com
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Independent Researcher, Bridgewater, NJ, USA.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Novichkov
authors.affiliation: Institute for Information Transmission Problems, RAS, Moscow, Russia.
authors.forename: Anna
authors.initials: A
authors.lastname: Kaznadzey
authors.affiliation: Genome Designs, Inc, Walnut Creek, CA, USA.
authors.forename: Natalia
authors.initials: N
authors.lastname: Alexandrova
authors.affiliation: Thermo-Fisher, South San Francisco, CA, USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Kaznadzey
mesh_terms: D004247:DNA; D030561:Databases, Nucleic Acid; D023281:Genomics; D010802:Phylogeny; D012984:Software
chemical_list: D004247:DNA