title: Characteristics of Venous Thromboembolism in Pancreatic Adenocarcinoma in East Asian Ethnics: A Large Population-Based Observational Study.
abstract: Pancreatic cancer (PC) is known to be frequently associated with venous thromboembolism (VTE). Although treatment and prophylaxis strategies for VTE in PC patients were updated recently, these were mainly based on data from Western populations and were not verified in East Asian ethnic populations.We investigated the clinical characteristics of VTE in East Asian PC patients. We reviewed electronic medical records (EMR) of 1334 patients diagnosed with pancreatic adenocarcinoma from 2005 to 2010 at single tertiary hospital in Korea. All the patients with newly diagnosed VTE were classified by anatomical site and manifestation of symptoms. The primary outcomes of interest were 2-year cumulative incidence of VTE events. Cox proportional hazards models were used to analyze associations between risk factors and clinical outcomes.A total of 1115 patients were eligible for enrollment. The 2-year cumulative VTE incidence was 9.2%. Major risk factors associated with VTE event were advanced cancer stage, major surgery, and poor performance status. Risk factors associated with mortality after PC diagnosis included advanced cancer stage, poor performance score, leukocytosis, and lower albumin level. The overall VTE did not affected mortality. However in subgroup analysis, symptomatic VTE and deep vein thrombosis/pulmonary thromboembolism (DVT/PTE) showed worse prognosis than incidental or intra-abdominal VTE.The overall incidence of VTE events in Korean PC patients was lower than previous studies. Advanced cancer stage was the most important factor for VTE event and mortality. Unlike Western population group, VTE event did not affect overall prognosis after PC diagnosis. However, symptomatic VTE and DVT/PTE showed higher mortality after VTE event.
authors.affiliation: From the Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam (J-CL, JC, YP, J-HH); Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute (YSR); Department of Radiology (JHL); and Division of Medical Oncology, Department of Internal Medicine (HJC, SL), Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jong-Chan
authors.initials: JC
authors.lastname: Lee
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Ro
authors.forename: Junhyeon
authors.initials: J
authors.lastname: Cho
authors.forename: Yohan
authors.initials: Y
authors.lastname: Park
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Lee
authors.forename: Jin-Hyeok
authors.initials: JH
authors.lastname: Hwang
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Choi
authors.forename: Soohyeon
authors.initials: S
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000208:ethnology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000208:ethnology* / Q000473:pathology; D011379:Prognosis; D056910:Republic of Korea; D012307:Risk Factors; D062606:Tertiary Care Centers; D054556:Venous Thromboembolism / Q000453:epidemiology* / Q000208:ethnology*