title: A Study on Central Lymph Node Metastasis in 543 cN0 Papillary Thyroid Carcinoma Patients.
abstract: Background. Papillary thyroid carcinoma (PTC) with central lymph node metastases (CLNMs) is common. The objective of this study was to investigate the incidence and risk factors of lymph node metastasis patients with PTC. Patients and Methods. Between January 2013 and February 2015, a retrospective study of 543 patients with PTC undergoing hemithyroidectomy or total thyroidectomy with routine central lymph node dissection (CLND) was analyzed. Clinicopathologic risk factors for CLNM were studied using univariate and multivariate analysis by SPSS 22.0 software. Results. The incidence of CLNMs in PTC patients was 38.1% (207/543). In the multivariate analysis, male gender (p < 0.001, OR: 1.984), age <45 years (p < 0.001, OR: 1.934), bilaterality (p = 0.006, OR: 1.585), tumor size ≥0.25 cm (p = 0.001, OR: 7.655), and external extension (p = 0.001, OR: 7.579) were independent risk factors of CLNMs. Furthermore, in PTC patients with tumor size <0.25 cm, all 7 males and 21 patients with unilaterality were not found to have CLNMs. Conclusions. CLNMs are prevalent in the PTC patients with the following risk factors: male gender, age <45 years, bilaterality, tumor size ≥0.25 cm, and external extension. PTC patients with tumor size <0.25 cm, male patients, and patients with unilateral lesion could be considered safe from CLNMs.
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ming
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Ruitao
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital of Nanjing Medical University, 201620 Shanghai, China.
authors.forename: Jun
authors.identifier: 0000-0001-5627-7015
authors.initials: J
authors.lastname: Liu