title: Design and optimization of a novel bio-loom to weave melt-spun absorbable polymers for bone tissue engineering.
abstract: Bone graft procedures are currently among the most common surgical procedures performed worldwide, but due to high risk of complication and lack of viable donor tissue, there exists a need to develop alternatives for bone defect healing. Tissue engineering, for example, combining biocompatible scaffolds with mesenchymal stem cells to achieve new bone growth, is a possible solution. Recent work has highlighted the potential for woven polymer meshes to serve as bone tissue engineering scaffolds; since, scaffolds can be iteratively designed by adjusting weave settings, material types, and mesh parameters. However, there are a number of material and system challenges preventing the implementation of such a tissue engineering strategy. Fiber compliance, tensile strength, brittleness, cross-sectional geometry, and size present specific challenges for using traditional textile weaving methods. In the current work, two potential scaffold materials, melt-spun poly-l-lactide, and poly-l-lactide-co-ε-caprolactone, were investigated. An automated bio-loom was engineered and built to weave these materials. The bio-loom was used to successfully demonstrate the weaving of these difficult-to-handle fiber types into various mesh configurations and material combinations. The dobby-loom design, adapted with an air jet weft placement system, warp tension control system, and automated collection spool, provides minimal damage to the polymer fibers while overcoming the physical constraints presented by the inherent material structure. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1342-1351, 2017.
authors.affiliation: Department of Bioengineering, College of Engineering and Science, Clemson University, Clemson, SC, USA.
authors.forename: Jordon
authors.initials: J
authors.lastname: Gilmore
authors.affiliation: Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Burg
authors.affiliation: Department of Electrical and Computer Engineering, College of Engineering and Science, Clemson University, Clemson, SC, USA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Groff
authors.affiliation: Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: Karen J L
authors.initials: KJL
authors.lastname: Burg
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D013526:Surgical Mesh; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D063566:Biodegradable Plastics; D018786:Bone Substitutes
keywords: bio-loom; bone tissue engineering; melt-spinning; mesh; woven scaffold