title: Formation of Highly Aligned Collagen Nanofibers by Continuous Cyclic Stretch of a Collagen Hydrogel Sheet.
abstract: A collagen sheet with highly aligned collagen fibers is fabricated by continuous cyclic stretch. The rearrangement of the collagen fibers depends on the different process parameters of the cyclic stretch, including magnitude, frequency, and period of stretch. The collagen fibers are aligned perpendicularly to the direction of the stretch. Corneal stromal cells and smooth muscle cells cultivated on the highly aligned collagen sheet show alignment along the collagen fibers without the stretch during culture. Thus, the sheet can be a suitable scaffold for use in regenerative medicine.
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-Ku, Tokyo, 153-8505, Japan.|Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Eunryel
authors.initials: E
authors.lastname: Nam
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-Ku, Tokyo, 153-8505, Japan.|Hanyang University, Ansan, Gyeonggi, 15588, South Korea.
authors.forename: Won Chul
authors.initials: WC
authors.lastname: Lee
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-Ku, Tokyo, 153-8505, Japan.|Takeuchi Biohybrid Innovation Project, xploratory Research for Advanced Technology (ERATO), JST, Tokyo, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Takeuchi
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D003094:Collagen / Q000737:chemistry* / Q000627:therapeutic use; D003315:Cornea / Q000187:drug effects; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000627:therapeutic use; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D003094:Collagen
keywords: collagen; continuous cyclic stretch; corneal stroma; highly aligned collagen nanofibers; smooth muscle cell