title: Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma.
abstract: Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21(st) century.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Megan L
authors.initials: ML
authors.lastname: Ludwig
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Birkeland
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Hoesli
authors.affiliation: Department of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Swiecicki
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Spector
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: J Chad
authors.initials: JC
authors.lastname: Brenner
keywords: Head and neck cancer; genetics; laryngeal squamous cell carcinoma; personalized medicine; targeted therapy