title: Knowledge and Perception about Clinical Research Shapes Behavior: Face to Face Survey in Korean General Public.
abstract: Considering general public as potential patients, identifying factors that hinder public participation poses great importance, especially in a research environment where demands for clinical trial participants outpace the supply. Hence, the aim of this study was to evaluate knowledge and perception about clinical research in general public. A total of 400 Seoul residents with no previous experience of clinical trial participation were selected, as representative of population in Seoul in terms of age and sex. To minimize selection bias, every fifth passer-by was invited to interview, and if in a cluster, person on the very right side was asked. To ensure the uniform use of survey, written instructions have been added to the questionnaire. Followed by pilot test in 40 subjects, the survey was administered face-to-face in December 2014. To investigate how perception shapes behavior, we compared perception scores in those who expressed willingness to participate and those who did not. Remarkably higher percentage of responders stated that they have heard of clinical research, and knew someone who participated (both, P < 0.001) compared to India. Yet, the percentage of responders expressed willingness to participate was 39.3%, a significantly lower rate than the result of the India (58.9% vs. 39.3%, P < 0.001). Treatment benefit was the single most influential reason for participation, followed by financial gain. Concern about safety was the main reason for refusal, succeeded by fear and lack of trust. Public awareness and educational programs addressing these negative perceptions and lack of knowledge will be effective in enhancing public engaged in clinical research.
authors.affiliation: Asan Medical Center, Clinical Trial Center, Seoul, Korea .
authors.forename: Yun Jung
authors.identifier: 0000-0002-1648-9264
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Asan Medical Center, Clinical Trial Center, Seoul, Korea .
authors.forename: Sung-Ho
authors.identifier: 0000-0003-4540-3041
authors.initials: SH
authors.lastname: Beck
authors.affiliation: Asan Medical Center, Clinical Trial Center, Seoul, Korea .
authors.forename: Woon Yong
authors.identifier: 0000-0002-4839-5342
authors.initials: WY
authors.lastname: Kang
authors.affiliation: Asan Medical Center, Human Research Protection Center, Seoul, Korea .
authors.forename: Soyoung
authors.identifier: 0000-0002-2953-508X
authors.initials: S
authors.lastname: Yoo
authors.affiliation: Asan Medical Center, Human Research Protection Center, Seoul, Korea.; Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Seong-Yoon
authors.identifier: 0000-0002-1077-6289
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Asan Medical Center, Clinical Research Center, Seoul, Korea .
authors.forename: Ji Sung
authors.identifier: 0000-0001-8194-3462
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Duke Global Proof-of-Concept (POC) Research Network, Duke Clinical Research Unit (DCRU) & Duke Clinical Research Institute (DCRI), Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
authors.forename: Tal
authors.identifier: 0000-0002-5853-6110
authors.initials: T
authors.lastname: Burt
authors.affiliation: Asan Medical Center, Clinical Trial Center, Seoul, Korea.; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Tae Won
authors.identifier: 0000-0001-9522-1997
authors.initials: TW
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001364:Awareness; D035843:Biomedical Research; D002986:Clinical Trials as Topic; D003710:Demography; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007194:India; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010465:Perception; D056910:Republic of Korea; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Awareness of Clinical Trial; Clinical Research Perception; Clinical Trial Participation; Patient Enrollment; Perception of Clinical Trial