title: Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation?
abstract: Inositol metabolism is severely impaired in follicles obtained from cystic ovaries, leading to deregulated insulin transduction and steroid synthesis. On the contrary, inositol administration to women suffering from polycystic ovary syndrome (PCOS) has been proven to efficiently counteract most of the clinical hallmarks displayed by PCOS patients, including insulin resistance, hyperandrogenism and oligo-amenorrhea. We have recently observed that myo-inositol induces significant changes in cytoskeletal architecture of breast cancer cells, by modulating different biochemical pathways, eventually modulating the epithelial-mesenchymal transition. We hypothesize that inositol and its monophosphate derivatives, besides their effects on insulin transduction, may efficiently revert histological and functional features of cystic ovary by inducing cytoskeleton rearrangements. We propose an experimental model that could address not only whether inositol modulates cytoskeleton dynamics in both normal and cystic ovary cells, but also whether this effect may interfere with ovarian steroidogenesis. A more compelling understanding of the mechanisms of action of inositol (and its derivatives) would greatly improve its therapeutic utilization, by conferring to current treatments a well-grounded scientific rationale.
authors.affiliation: Department of Experimental Medicine, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy; Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy. Electronic address: mariano.bizzarri@uniroma1.it.
authors.forename: Mariano
authors.initials: M
authors.lastname: Bizzarri
authors.affiliation: Department of Surgery "Pietro Valdoni", Sapienza University of Rome, Via A. Scarpa 14, 00161 Rome, Italy; Azienda Policlinico Umberto I, viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cucina
authors.affiliation: Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy; Department of Surgery "Pietro Valdoni", Sapienza University of Rome, Via A. Scarpa 14, 00161 Rome, Italy; Department of Clinical and Molecular Medicine, Via A. Scarpa 14, 00161 Rome, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Dinicola
authors.affiliation: Department of Zoology, College of Science, King Saud University, PO Box 2455, 11451 Riyadh, Saudi Arabia.
authors.forename: Abdel Halim
authors.initials: AH
authors.lastname: Harrath
authors.affiliation: Department of Zoology, College of Science, King Saud University, PO Box 2455, 11451 Riyadh, Saudi Arabia.
authors.forename: Saleh H
authors.initials: SH
authors.lastname: Alwasel
authors.affiliation: Lo.Li Pharma Medical Department, Rome, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Unfer
authors.affiliation: Department of Psychology, Section of Neuroscience, Sapienza University of Rome, Via dei Marsi 78, 00185 Rome, Italy.
authors.forename: Arturo
authors.initials: A
authors.lastname: Bevilacqua
mesh_terms: D000568:Amenorrhea / Q000188:drug therapy; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D003338:Corpus Luteum / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism* / Q000627:therapeutic use; D007333:Insulin Resistance; D008962:Models, Theoretical; D009865:Oocytes / Q000166:cytology; D006080:Ovarian Follicle / Q000187:drug effects* / Q000378:metabolism; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D051381:Rats
chemical_list: D015820:Cadherins; D007294:Inositol