title: Antinociceptive Activity of an Ethanol Extract of Justicia spicigera.
abstract: Preclinical Research The aim of the present study was to evaluate the antinociceptive and sedative activity of an ethanol extract of Justicia spicigera an evergreen used in Mexican traditional medicine for the relief of pain, wounds, fever and inflammation. At 200 mg/kg po, the maximum dose examined, the ethanol extract of J. spicigera (JSE) had analgesic activity in mice in the acetic acid writhing test, the second phase of the formalin test and the tail flick test that was similar in efficacy to the NSAID, naproxen (150 mg/kg po). JSE was inactive in the hot plate test and and the ketamine-induced sleeping time test; it had no sedative effects. These results show that the ethanol extract from the leaves of J. spicigera has antinociceptive effects in mice without inducing sedation. Drug Dev Res 77 : 180-186, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato (Gto), CP, 36050, Mexico.
authors.forename: Juan Ramón
authors.initials: JR
authors.lastname: Zapata-Morales
authors.affiliation: Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato (Gto), CP, 36050, Mexico.
authors.forename: Angel Josabad
authors.initials: AJ
authors.lastname: Alonso-Castro
authors.affiliation: Centro de Investigación Biomédica de Oriente, IMSS, Metepec, Puebla, Mexico.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Domínguez
authors.affiliation: Unidad Académica Multidisciplinaria Zona Huasteca, Universidad Autónoma de San Luis Potosí, Ciudad Valles, San Luis Potosí, Mexico.
authors.forename: Candy
authors.initials: C
authors.lastname: Carranza-Álvarez
authors.affiliation: Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato (Gto), CP, 36050, Mexico.
authors.forename: Luis Manuel Orozco
authors.initials: LM
authors.lastname: Castellanos
authors.affiliation: Laboratorio de Farmacología y Fisiología, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Martínez-Medina
authors.affiliation: Laboratorio de Farmacología y Fisiología, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Pérez-Urizar
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D004195:Disease Models, Animal; D000431:Ethanol / Q000737:chemistry; D027902:Justicia / Q000737:chemistry*; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D009288:Naproxen / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D000431:Ethanol; D009288:Naproxen
keywords: Justicia spicigera; antinociception; herbal medicine; kaempferitrin; pain