title: Potential use of SERS-assisted theranostic strategy based on Fe3O4/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia.
abstract: A surface-enhanced Raman scattering (SERS)-assisted theranostic strategy was designed based on a synthesized multifunctional Fe3O4/Au cluster/shell nanocomposite. This theranostic strategy was used for free prostate specific antigen (free-PSA) detection, magnetic resonance imaging (MRI), and magnetic hyperthermia. The lowest protein concentration detected was 1ngmL(-1), and the limit of detection (LOD) of the calculated PSA was 0.75ngmL(-1). Then, MRI was carried out to visualize the tumor cell. Lastly, magnetic hyperthermia was employed and revealed a favorable killing effect for the tumor cells. Thus, this SERS-assisted strategy based on a Fe3O4/Au cluster/shell nanocomposite showed great advantages in theranostic treatment.
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Sheng-Lan
authors.initials: SL
authors.lastname: Lei
authors.affiliation: Department of Electronic Science, College of Physical Science and Technology, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Lu
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Electronic Science, College of Physical Science and Technology, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen 361005, People's Republic of China. Electronic address: chenzhiwei@xmu.edu.cn.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Chen
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China; State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, People's Republic of China; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen 361005, People's Republic of China. Electronic address: renlei@xmu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Ren
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China; Fujian Provincial Key Laboratory of Fire Retardant Materials, Xiamen University, Xiamen 361005, People's Republic of China; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen 361005, People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhou
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D052203:Ferrosoferric Oxide / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006979:Hyperthermia, Induced; D055909:Magnetic Field Therapy; D008279:Magnetic Resonance Imaging; D053761:Nanocomposites / Q000737:chemistry*; D000068936:Theranostic Nanomedicine
chemical_list: D003287:Contrast Media; D006046:Gold; D052203:Ferrosoferric Oxide
keywords: Fe(3)O(4)@Au nanoparticles; MRI; Magnetic hyperthermia; Multifunction; PSA detection; SERS