title: Lactic acid bacteria as mucosal delivery vehicles: a realistic therapeutic option.
abstract: Recombinant lactic acid bacteria (LAB), in particular lactococci and lactobacilli, have gained increasing interest as mucosal delivery vehicles in recent years. With the development of mucosal vaccines, studies on LAB expression systems have been mainly focused on the generation of genetic tools for antigen expression in different locations. Recombinant LAB show advantages in a wide range of aspects over other mucosal delivery systems and represent an attractive candidate for the delivery of therapeutic and prophylactic molecules in different applications. Here, we review the recent data on the use of recombinant LAB as mucosal delivery vectors and the associated health benefits, including the prevention and treatment of inflammatory bowel diseases (IBDs), autoimmune disorders, and infections by pathogenic microorganisms from mucosal surfaces. In addition, we discuss the use of LAB as vehicles to deliver DNA directly to eukaryotic cells. Researches from the last 5 years demonstrate that LAB as vectors for mucosal delivery of therapeutic molecules seem to be a realistic therapeutic option both in human and animal diseases.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu, 730046, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu, 730046, China.
authors.forename: Zeqian
authors.initials: Z
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu, 730046, China. yongguang.zhang@163.com.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China. yongguang.zhang@163.com.
authors.forename: Yongguang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu, 730046, China. panli@caas.cn.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China. panli@caas.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Pan
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D007778:Lactobacillus / Q000235:genetics* / Q000378:metabolism; D009092:Mucous Membrane / Q000187:drug effects*; D014612:Vaccines / Q000235:genetics / Q000276:immunology
chemical_list: D014612:Vaccines; D019344:Lactic Acid; D004247:DNA
keywords: DNA vaccines; Delivery vehicles; Lactic acid bacteria; Mucosal immunity; Mucosal vaccines; Therapeutic molecules