title: Tumor suppressor in lung cancer 1 gene expression in epithelial ovarian cancer.
abstract: OBJECTIVE
  Loss of Tumor Suppressor in Lung Cancer 1(TSLC1) was observed in many different cancers, but there were only limited research on TSLC1 gene and its roles in cancer suppression in ovarian cancer. This study explores the relationship between TSLC1 gene expression and the ovarian epithelial cancer.
  
  
  METHODS
  Expression levels of TSLC1 were detected by immunohistochemical staining on formal-fixed paraffin embedded pathological specimen. A total of 259 samples were collected, including 24 benign ovarian tumor and 235 malignant ovarian cancers among them.
  
  
  RESULTS
  Suppressed expression of TSLC1 protein was observed in 87.8% of poorly differentiated, 85.1% of moderately differentiated, and 46% of well differentiated ovarian epithelial cancers, respectively. There were none suppressed TSLC1 expression in benign ovarian tumor. Kruskal-Wallis test showed a significant association between the expression levels of TSLC1 gene and the degree of ovarian cancer differentiation (P < 0.001).
  
  
  CONCLUSIONS
  Decreased expression of TSLC1 is associated with the differentiation in ovarian epithelial cancer. TSLC1 might be used as a molecular marker of severity in early stage ovarian cancer, and to help differentiating benign and malignant ovarian tumors.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Qu
authors.affiliation: Obstetrics and Gynecology, The First Affiliated Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Feixue
authors.initials: F
authors.lastname: Xu
authors.affiliation: Epidemic and Health Statistics Institute, Public Health College, Lanzhou University, Lanzhou 730000, China.
authors.forename: Yana
authors.initials: Y
authors.lastname: Bai
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Si
authors.forename: Aihong
authors.initials: A
authors.lastname: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D000077216:Carcinoma, Ovarian Epithelial; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C403514:CADM1 protein, human; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins