title: [Lynch syndrome, Muir Torre variant: 2 cases].
abstract: Lynch syndrome (LS) is an autosomal-dominant inherited cancer predisposition syndrome caused by germline mutations in DNA mismatch repair genes (MLH1, MSH2, MSH6 or PMS2). Muir-Torre syndrome (MTS) is a phenotypic variant of LS that includes a predisposition to sebaceous glands tumors and keratoacanthomas. We report two patients with MTS, with more than one LS-related cancer, skin lesions, family history of cancer andmicrosatellite instability and immunohistochemistry analysis.
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Castro-Mujica
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Claudia
authors.initials: C
authors.lastname: Barletta-Carrillo
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú; Universidad Peruana Cayetano Heredia. Lima, Perú.
authors.forename: Marisa
authors.initials: M
authors.lastname: Acosta-Aliaga
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú; Universidad Peruana Cayetano Heredia. Lima, Perú.
authors.forename: Ximena
authors.initials: X
authors.lastname: Montenegro-Garreaud
mesh_terms: D005260:Female; D006801:Humans; D053842:Microsatellite Instability; D008875:Middle Aged; D055653:Muir-Torre Syndrome / Q000175:diagnosis* / Q000235:genetics; D010375:Pedigree