title: Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces.
abstract: Engineering interfaces of distinct extracellular compartments mimicking native tissues are key for in-depth in vitro studies on developmental and disease processes in biology and medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar collagen I networks with a multiparameter control of topology, mechanics, and composition, and their distinct impact on triggering the directionality of cancer cell migration is demonstrated.
authors.affiliation: Institute of Biochemistry, Universität Leipzig, 04103, Leipzig, Germany.
authors.forename: Jiranuwat
authors.initials: J
authors.lastname: Sapudom
authors.affiliation: Institute of Biochemistry, Universität Leipzig, 04103, Leipzig, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Rubner
authors.affiliation: Institute of Biochemistry, Universität Leipzig, 04103, Leipzig, Germany.
authors.forename: Steve
authors.initials: S
authors.lastname: Martin
authors.affiliation: Institute of Biochemistry, Universität Leipzig, 04103, Leipzig, Germany.
authors.forename: Tilo
authors.initials: T
authors.lastname: Pompe
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D002465:Cell Movement; D024042:Collagen Type I / Q000737:chemistry*; D005109:Extracellular Matrix / Q000737:chemistry*; D005260:Female; D006801:Humans
chemical_list: D024042:Collagen Type I
keywords: biomaterials; biopolymer networks; cancer cell migration; matrix engineering; matrix interfaces