title: Klotho Prevents Translocation of NFκB.
abstract: Klotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions. The activation of cellular systems is associated with the pathogenesis of several chronic and degenerative diseases associated with an inflammatory state. Inflammation is characterized by an activation of NFκB. Klotho suppresses nuclear factor NFκB activation and the subsequent transcription of proinflammatory genes. This review focuses on the current understanding of Klotho protein function and its relationship with NFκB regulation, emphasizing its potential involvement in the pathophysiologic process.
authors.affiliation: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba/Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Buendía
authors.affiliation: Alcalá de Henares University, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Ramírez
authors.affiliation: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba/Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Aljama
authors.affiliation: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba/Hospital Universitario Reina Sofía, Córdoba, Spain. Electronic address: julia.carracedo.exts@juntadeandalucia.es.
authors.forename: J
authors.initials: J
authors.lastname: Carracedo
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases; D016922:Cellular Senescence / Q000502:physiology; D003920:Diabetes Mellitus; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D000071161:Forkhead Box Protein O1 / Q000235:genetics; D005966:Glucuronidase / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006728:Hormones; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007328:Insulin / Q000378:metabolism; D000090265:Klotho Proteins; D016328:NF-kappa B / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive; D017468:Receptors, Fibroblast Growth Factor; D051436:Renal Insufficiency, Chronic; D015398:Signal Transduction / Q000502:physiology
chemical_list: C000717427:FGF23 protein, human; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D006728:Hormones; D007328:Insulin; D016328:NF-kappa B; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: Chronic kidney disease; FGF-23; Inflammation; Klotho; NFκB; Oxidative stress; Senescence