title: Noncoding Regulatory RNAs in Hematopoiesis.
abstract: Hematopoiesis is a dynamic process in which blood cells are continuously generated from hematopoietic stem cells (HSCs). The regulatory mechanisms controlling HSC fate have been studied extensively over the past several decades. Although many protein-coding genes have been shown to regulate hematopoietic differentiation, additional levels of HSC regulation are not well studied. Advances in deep sequencing have revealed many new classes of regulatory noncoding RNAs (ncRNAs), such as enhancer RNAs and antisense ncRNAs. Functional analysis of some of these ncRNAs has provided insights into the molecular mechanisms that regulate hematopoietic development and disease. In this review, we summarize recent advances in our understanding of functional regulatory ncRNAs associated with hematopoietic self-renewal and differentiation, as well as those dysregulated ncRNAs involved in hematologic malignancies.
authors.affiliation: Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, United States.
authors.forename: M
authors.initials: M
authors.lastname: Jeong
authors.affiliation: Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, United States. Electronic address: goodell@bcm.edu.
authors.forename: M A
authors.initials: MA
authors.lastname: Goodell
mesh_terms: D000818:Animals; D015415:Biomarkers; D049109:Cell Proliferation / Q000235:genetics; D004742:Enhancer Elements, Genetic; D041905:Erythroid Cells / Q000473:pathology; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology / Q000502:physiology; D022423:Myeloid Cells / Q000473:pathology / Q000502:physiology; D016372:RNA, Antisense; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
chemical_list: D015415:Biomarkers; D016372:RNA, Antisense; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
keywords: Antisense noncoding transcripts; Erythropoiesis; Hematopoiesis; Hematopoietic malignancies; Hematopoietic stem cells; Lymphopoiesis; Myelopoiesis; eRNAs; lncRNAs