title: Detection of Epileptic Seizures Using Phase-Amplitude Coupling in Intracranial Electroencephalography.
abstract: Seizure detection using intracranial electroencephalography (iEEG) contributes to improved treatment of patients with refractory epilepsy. For that purpose, a feature of iEEG to characterize the ictal state with high specificity and sensitivity is necessary. We evaluated the use of phase-amplitude coupling (PAC) of iEEG signals over a period of 24 h to detect the ictal and interictal states. PAC was estimated by using a synchronisation index (SI) for iEEG signals from seven patients with refractory temporal lobe epilepsy. iEEG signals of the ictal state was characterised by a strong PAC between the phase of β and the amplitude of high γ. Furthermore, using SI values, the ictal state was successfully detected with significantly higher accuracy than by using the amplitude of high γ alone. In conclusion, PAC accurately distinguished the ictal state from the interictal state.
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.
authors.forename: Kohtaroh
authors.initials: K
authors.lastname: Edakawa
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.|ATR Computational Neuroscience Laboratories, Department of Neuroinformatics, Seika-cho 619-0288, Kyoto, Japan.|JST PRESTO, Suita 565-0871, Osaka, Japan.|Osaka University Graduate School of Medicine, Division of Functional Diagnostic Science, Suita 565-0871, Osaka, Japan.
authors.forename: Takufumi
authors.initials: T
authors.lastname: Yanagisawa
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kishima
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|ATR Computational Neuroscience Laboratories, Department of Neuroinformatics, Seika-cho 619-0288, Kyoto, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Fukuma
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Oshino
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Khoo
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita 565-0871, Osaka, Japan.|Osaka University Hospital Epilepsy Center, Suita 565-0871, Osaka, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yoshimine
mesh_terms: D000328:Adult; D003936:Diagnosis, Computer-Assisted; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D012640:Seizures / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D055815:Young Adult