title: Key roles of autophagy in regulating T-cell function.
abstract: In the past 10 years, autophagy has emerged as a crucial regulator of T-cell homeostasis, activation, and differentiation. Through the ability to adjust the cell's proteome in response to different stimuli, different forms of autophagy have been shown to control T-cell homeostasis and survival. Autophagic processes can also determine the magnitude of the T-cell response to TCR engagement, by regulating the cellular levels of specific signaling intermediates and modulating the metabolic output in activated T cells. In this review we will examine the mechanisms that control autophagy activity in T cells, such as ROS signaling and signaling through common gamma-chain cytokine receptors, and the different aspect of T-cell biology, including T-cell survival, effector cell function, and generation of memory, which can be regulated by autophagy.
authors.affiliation: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Yair
authors.initials: Y
authors.lastname: Botbol
authors.affiliation: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Guerrero-Ros
authors.affiliation: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Fernando
authors.initials: F
authors.lastname: Macian
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity; D001343:Autophagy / Q000235:genetics / Q000276:immunology; D002470:Cell Survival / Q000235:genetics / Q000276:immunology; D004734:Energy Metabolism; D006706:Homeostasis; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D000068884:Immunosenescence; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D018832:Molecular Chaperones / Q000378:metabolism; D015388:Organelles / Q000276:immunology / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
chemical_list: D018832:Molecular Chaperones; D011948:Receptors, Antigen, T-Cell
keywords: Autophagy; Chaperone-mediated autophagy; Macroautophagy; Metabolism; T cell