title: Remote Control of T Cell Activation Using Magnetic Janus Particles.
abstract: We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single-cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle-cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single-cell activities without the need of complex magnetic manipulation devices.
authors.affiliation: Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.
authors.forename: Kwahun
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA. yy33@indiana.edu.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
mesh_terms: D003102:Colloids / Q000737:chemistry; D008213:Lymphocyte Activation; D060526:Magnetic Fields; D010316:Particle Size; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D003102:Colloids
keywords: Janus particles; colloids; immunology; magnetic properties; nanotechnology