title: Rhodium-catalyzed asymmetric hydrogenation of unprotected β-enamine phosphonates.
abstract: We have successfully developed a strategy for the first time for the enantioselective Rh-TaniaPhos catalyzed asymmetric hydrogenation of unprotected β-enamine phosphonates to free β-amino phosphonates directly with good enantioselectivities (80%-86% ee) and high conversions (>99% conversion). The resulting chiral free β-amino phosphonates and their derivatives are important intermediates in biochemistry and pharmaceuticals.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn.
authors.forename: Zejian
authors.initials: Z
authors.lastname: Xue
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang