title: Long-term outcomes of modified laparoscopic sacrocolpopexy for advanced pelvic organ prolapse: a 3-year prospective study.
abstract: The aim of the study was to evaluate the anatomical and functional outcomes of modified laparoscopic sacrocolpopexy (MLSC) for the treatment of advanced pelvic organ prolapse (POP).
  
  
  
  From May 2009 to September 2012, a consecutive prospective observational study of 30 participants was conducted to evaluate MLSC as a treatment for symptomatic advanced POP at Peking Union Medical College Hospital. The Pelvic Organ Prolapse Quantification (POP-Q) classification was used to determine the POP stage. Validated tools were used to evaluate symptoms (Pelvic Floor Distress Inventory, PFDI-20) and sexual function (Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire, PISQ-12). Measurements were recorded preoperatively and then at 3 months and yearly after surgery. We compared the follow-up results with the preoperative data.
  
  
  
  All participants completed a 3-year clinical follow-up routine. The anatomical results at 3 months showed significant improvements (P < 0.05) compared with the preoperative results based on the POP-Q measurements. This improvement remained significant after 3 years (P < 0.05). The anatomical cure rate was 100% and 96.7% at 3 months and 3 years after surgery, respectively. Pelvic floor function remained significantly improved after surgery compared with preceding surgery (P < 0.05) according to the following measures: PFDI-20 (106.2 vs 36.0), Pelvic Organ Prolapse Distress Inventory-6 (POPDI-6, 47.9 vs 13.7), Colorectal-Anal Distress Inventory-8 (CRADI-8, 29.2 vs 9.2), and Urinary Distress Inventory-6 (UDI-6, 29.2 vs 13.2). The participants maintained a high level of sexual function (PISQ-12: 29.0 vs 35.1, P < 0.05). One case of mesh exposure (3.3%) and two cases of de novo dyspareunia (8.7%) were observed.
  
  
  
  MLSC seems to be a safe and effective procedure that achieves good long-term anatomical and functional results.
authors.affiliation: 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China 2Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, PR China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Liang
authors.forename: Lan
authors.initials: L
authors.lastname: Zhu
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Song
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Zhijing
authors.initials: Z
authors.lastname: Sun
authors.forename: Jinghe
authors.initials: J
authors.lastname: Lang
mesh_terms: D000328:Adult; D003127:Colposcopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008875:Middle Aged; D017773:Pelvic Floor / Q000601:surgery*; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011446:Prospective Studies; D012447:Sacrum / Q000601:surgery*; D012725:Sexual Behavior; D013526:Surgical Mesh; D013995:Time; D016896:Treatment Outcome; D014621:Vagina / Q000601:surgery