title: Association Analysis Suggests SOD2 as a Newly Identified Candidate Gene Associated With Leprosy Susceptibility.
abstract: Genetic studies have identified several genes and genomic regions contributing to the control of host susceptibility to leprosy. Here, we test variants of the positional and functional candidate gene SOD2 for association with leprosy in 2 independent population samples. Family-based analysis revealed an association between leprosy and allele G of marker rs295340 (P = .042) and borderline evidence of an association between leprosy and alleles C and A of markers rs4880 (P = .077) and rs5746136 (P = .071), respectively. Findings were validated in an independent case-control sample for markers rs295340 (P = .049) and rs4880 (P = .038). These results suggest SOD2 as a newly identified gene conferring susceptibility to leprosy.
authors.affiliation: Graduate Program in Health Sciences, School of Medicine.
authors.forename: Geovana Brotto
authors.initials: GB
authors.lastname: Ramos
authors.affiliation: Graduate Program in Health Sciences, School of Medicine.
authors.forename: Heloisa
authors.initials: H
authors.lastname: Salomão
authors.affiliation: Graduate Program in Health Sciences, School of Medicine.
authors.forename: Angela Schneider
authors.initials: AS
authors.lastname: Francio
authors.affiliation: Program in Infectious Diseases and Immunity in Global Health, Research Institute of the McGill University Health Centre McGill International TB Centre Department of Human Genetics Department of Medicine, McGill University, Montreal, Canada.
authors.forename: Vinícius Medeiros
authors.initials: VM
authors.lastname: Fava
authors.affiliation: Graduate Program in Health Sciences, School of Medicine School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
authors.forename: Renata Iani
authors.initials: RI
authors.lastname: Werneck
authors.affiliation: Graduate Program in Health Sciences, School of Medicine School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
authors.forename: Marcelo Távora
authors.initials: MT
authors.lastname: Mira
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005796:Genes; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007918:Leprosy / Q000235:genetics* / Q000276:immunology*; D008297:Male; D013482:Superoxide Dismutase / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2
keywords: SOD2; association study; infectious diseases; leprosy; polymorphism