title: First Report of a Verona Integron-Encoded Metallo-β-Lactamase-Producing Klebsiella pneumoniae Infection in a Child in the United States.
abstract: We report the first case of a child in the United States infected with an organism producing a Verona Integron-Encoded Metallo-β-Lactamase. This child succumbed to a ventilator-associated pneumonia caused by a Klebsiella pneumoniae producing this resistance mechanism.
authors.affiliation: Divisions of Pediatric Infectious Diseases.
authors.forename: Pranita D
authors.initials: PD
authors.lastname: Tamma
authors.affiliation: Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.
authors.forename: Nuntra
authors.initials: N
authors.lastname: Suwantarat
authors.affiliation: Research Service.
authors.forename: Susan D
authors.initials: SD
authors.lastname: Rudin
authors.affiliation: Section of Pediatric Infectious Diseases, Department of Pediatrics, Rush University Medical Center, Rush Medical College, Chicago, Illinois Louis Stokes Cleveland Department of Veterans Affairs Medical Center.
authors.forename: Latania K
authors.initials: LK
authors.lastname: Logan
authors.affiliation: Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Simner
authors.affiliation: Research Service Department of Medicine Department of Molecular Biology and Microbiology.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Rojas
authors.affiliation: Research Service Department of Medicine Department of Biochemistry.
authors.forename: Maria F
authors.initials: MF
authors.lastname: Mojica
authors.affiliation: Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Karen C
authors.initials: KC
authors.lastname: Carroll
authors.affiliation: Geriatrics Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Ohio Department of Medicine Department of Molecular Biology and Microbiology Department of Biochemistry Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
mesh_terms: D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D017809:Fatal Outcome; D006801:Humans; D032023:Integrons; D007710:Klebsiella Infections / Q000175:diagnosis* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D053717:Pneumonia, Ventilator-Associated / Q000175:diagnosis* / Q000382:microbiology*; D014481:United States; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D001618:beta-Lactamases
keywords: CRE; VIM; carbapenemase; metallo-β-lactamase; pediatrics