title: Induced Foxp3(+) T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells.
abstract: Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3(+) Treg. Here, we show that both in vitro and in vivo generated antigen-specific Foxp3(+) Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model.
authors.affiliation: Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Hilbrands
authors.affiliation: Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
authors.forename: Adrian R
authors.initials: AR
authors.lastname: Kendal
authors.affiliation: Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Adams
authors.affiliation: Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Cobbold
authors.affiliation: Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
authors.forename: Herman
authors.initials: H
authors.lastname: Waldmann
authors.affiliation: Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
authors.forename: Duncan
authors.initials: D
authors.lastname: Howie
keywords: Foxp3; hypomethylation; regulatory T cells; tolerance; transplantation