title: RNA modifications: what have we learned and where are we headed?
abstract: Proper control of the transcriptome is key for diverse aspects of gene expression, cellular functions and development, and its disruption can result in disease. A rapidly accumulating wealth of studies are identifying and functionally characterizing diverse types of RNA base modifications in protein-coding and non-coding RNAs, which have energized the emerging field of 'epitranscriptomics'. In this Viewpoint article, five experts discuss our latest understanding of RNA modifications, including recommendations for best practices and visions for the future.
authors.affiliation: Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
authors.forename: Michaela
authors.initials: M
authors.lastname: Frye
authors.affiliation: Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York City, New York 10065, USA.
authors.forename: Samie R
authors.initials: SR
authors.lastname: Jaffrey
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Pan
authors.affiliation: Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel; and the Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Gideon
authors.initials: G
authors.lastname: Rechavi
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D057890:Epigenomics / Q000379:methods*; D006801:Humans; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D062085:RNA, Long Noncoding / Q000235:genetics*; D014158:Transcription, Genetic; D059467:Transcriptome
chemical_list: D062085:RNA, Long Noncoding; D012313:RNA