title: Classification of infantile nystagmus waveforms.
abstract: Classification of infantile nystagmus waveforms is an important problem because the characteristic waveforms can be used to distinguish between infantile and acquired nystagmus. A clear description of the nystagmus is also a necessary first stage in understanding its origin. Currently infantile nystagmus waveforms are classified into at least 12 different types. In this study we analyse a database of nystagmus recordings in order to investigate if this classification can be simplified. Application of principal components analysis revealed that 96.9% of the variance of the waveforms is described by a linear sum of two component waveforms. The components consist of sawtooth and pseudocycloid waveforms that account for 78.7% and 18.2% of the variance respectively for the most common single cycle waveforms. This simplified description of infantile nystagmus highlights the importance of identifying the origin of the jerk component and its synchronisation with the pseudocycloid component for the characterisation and treatment of the nystagmus.
authors.affiliation: Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom; Paediatric Ophthalmology and Strabismus, Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, United Kingdom. Electronic address: Maria.Theodorou@moorfields.nhs.uk.
authors.forename: Maria
authors.initials: M
authors.lastname: Theodorou
authors.affiliation: Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom; College of Engineering, Mathematics & Physical Sciences, University of Exeter, Exeter EX4 4QF, United Kingdom.
authors.forename: Richard
authors.initials: R
authors.lastname: Clement
mesh_terms: D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020417:Nystagmus, Congenital / Q000175:diagnosis; D009759:Nystagmus, Pathologic / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology
keywords: Eye motility; Nystagmus; Waveforms