title: Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule-associated protein-like 4-anaplastic lymphoma translocation: A case report.
abstract: Squamous cell lung cancer (SCC) presenting with anaplastic lymphoma kinase (ALK) translocation is rare. We present a case of ALK gene translocation-SCC in which a remarkable tumor response to crizotinib was achieved after the failure of prior chemoradiotherapy. Considering this remarkable response, we conclude that ALK testing in female non-smokers or in any patient unresponsive to the initial regimen of chemotherapy, is recommended for SCC patients.
authors.affiliation: Department of Chemotherapy Zhejiang Cancer Hospital Hangzhou China.
authors.forename: Wenxian
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Chemotherapy Zhejiang Cancer Hospital Hangzhou China; Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology Hangzhou China.
authors.forename: Zhengbo
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Chemotherapy Zhejiang Cancer Hospital Hangzhou China; Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology Hangzhou China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Zhang
keywords: Crizotinib; EML4‐ALK; squamous cell lung cancer