title: Key role of 5-HT3receptors in the nucleus tractus solitarii in cardiovagal stress reactivity.
abstract: Serotonin plays a modulatory role in central control of the autonomic nervous system (ANS). The nucleus tractus solitarii (NTS) in the medulla is an area of viscerosomatic integration innervated by both central and peripheral serotonergic fibers. Influences from different origins therefore trigger the release of serotonin into the NTS and exert multiple influences on the ANS. This major influence on the ANS is also mediated by activation of several receptors in the NTS. In particular, the NTS is the central zone with the highest density of serotonin3(5-HT3) receptors. In this review, we present evidence that 5-HT3receptors in the NTS play a key role in one of the crucial homeostatic responses to acute and chronic stress: inhibitory modulation of the parasympathetic component of the ANS. The possible functional interactions of 5-HT3receptors with GABAAand NK1receptors in the NTS are also discussed.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France. Electronic address: caroline.sevoz-couche@upmc.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Sévoz-Couche
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
authors.forename: Charly
authors.initials: C
authors.lastname: Brouillard
mesh_terms: D006801:Humans; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin; D017552:Solitary Nucleus
chemical_list: D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin