title: Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology.
abstract: In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform. PRACTALL is an initiative of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction, and design of disease-modifying strategies. Progress has been made in profiling the type 2 immune response-driven asthma. The endotype driven approach for non-type 2 immune response asthma, rhinitis, and atopic dermatitis is lagging behind. Validation and qualification of biomarkers are needed to facilitate their translation into pathway-specific diagnostic tests. Wide consensus between academia, governmental regulators, and industry for further development and application of precision medicine in management of allergic diseases is of utmost importance. Improved knowledge of disease pathogenesis together with defining validated and qualified biomarkers are key approaches to precision medicine.
authors.affiliation: Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy. Electronic address: muraro@centroallergiealimentari.eu.
authors.forename: Antonella
authors.initials: A
authors.lastname: Muraro
authors.affiliation: Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Lemanske
authors.affiliation: Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Hellings
authors.affiliation: Swiss Institute of Allergy and Asthma Research, University of Zurich, Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
authors.forename: Cezmi A
authors.initials: CA
authors.lastname: Akdis
authors.affiliation: Department of Dermatology and Allergy, Christine Kühne-Center for Allergy Research and Education, Friedrich-Wilhelms-University, Bonn, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bieber
authors.affiliation: Department of Internal Medicine, University of South Florida, Tampa, Fla.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Casale
authors.affiliation: Department of Clinical Immunology, Wrocław Medical University, and ALL-MED Medical Research Institute, Wroclaw, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Jutel
authors.affiliation: Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, and the Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
authors.forename: Peck Y
authors.initials: PY
authors.lastname: Ong
authors.affiliation: Allergy Clinic Copenhagen University Hospital at Gentofte, Copenhagen, Denmark.
authors.forename: Lars K
authors.initials: LK
authors.lastname: Poulsen
authors.affiliation: Allergy Unit, Department for Dermatology, University of Zurich, Zurich, Switzerland, Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Schmid-Grendelmeier
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: Hans-Uwe
authors.initials: HU
authors.lastname: Simon
authors.affiliation: Laboratory of Clinical Immunology, University of Leuven, Leuven, Belgium.
authors.forename: Sven F
authors.initials: SF
authors.lastname: Seys
authors.affiliation: Department of Allergy and Clinical Immunology, Transylvania University, Brasov, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Agache
mesh_terms: D001249:Asthma / Q000188:drug therapy / Q000276:immunology; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000276:immunology; D005060:Europe; D006801:Humans; D057285:Precision Medicine; D012137:Respiratory System / Q000276:immunology; D012220:Rhinitis / Q000188:drug therapy / Q000276:immunology; D012867:Skin / Q000276:immunology; D012958:Societies, Scientific
keywords: Precision medicine; allergic asthma; allergic rhinitis; allergic skin disease; biomarker; endotype; personalized care; phenotype