title: The association between the LRRK2 R1628P variant and the risk of Parkinson's disease in Asian: a meta-analysis.
abstract: Many published case-control studies have investigated the association between Leucine-rich repeat kinase 2(LRRK2) R1628P and the susceptibility of Parkinson's disease (PD). However, controversial results were obtained. Herein we performed this meta-analysis to assess the association between the LRRK2 R1628P variants and the risk of PD. Up to January of 2016, 5 databases were searched to identify case-control studies involving LRRK2 R1628P variants and PD risk. A total of 5736 PD patients and 4786 controls in 14 case-control studies were included in this meta-analysis. And STATA 12.0 statistics software was used to calculate available data from each study. The pooled odds ratios (OR) and 95% confidence interval (CI) were calculated to assess the genetic association between LRRK2 R1628P polymorphism and the risk of PD. The results indicated that LRRK2 R1628P variants were increased risk of PD when all studies were pooled (C vs. G OR=1.983, 95% CI 1.640-2.399; GC+CC vs. GG OR=1.971, 95% CI 1.625-2.391). Moreover, in the subgroup analysis by ethnicity, increased risks were identified among Chinese (GC+CC vs. GG, OR=1.96, 95% CI 1.60-2.41) as well as in non-Chinese Asian races (GC+CC vs. GG, OR=2.03, 95% CI 1.13-3.65). Therefore, our results suggest that the C allele, GC and CC genotype of LRRK2 R1628P variants contribute to the susceptibility of PD in Asian.
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xue
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: xieanmu@163.com.
authors.forename: Anmu
authors.initials: A
authors.lastname: Xie
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Q000235:genetics*; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
keywords: Meta-analysis; Parkinson’s disease; Polymorphism; R1628P