title: [Progress of Research on 6-Thioguanine versus 6-Mercaptopurine in childhood ALL].
abstract: Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. Despite good remission rate has achieved nowadays, the patients still face a substantial risk of relapse. It has long been recognized that thiopurines are critical components in the treatment for prevention of recurrence in childhood ALL, the 6-mercaptopurine (6-MP) has usually been used in daily long-term maintenance therapy, and 6-thioguanine (6-TG) limited to the reinforcement of therapy. However, there is no optimal regimen for 6-TG or 6-MP. The related research advances on the clinical effectiveness of the two thiopurines are reviewed.
authors.affiliation: Department of Hematology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
authors.forename: Yu-Jiao
authors.initials: YJ
authors.lastname: Hou
authors.affiliation: Central Laboratory, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China. E-mail: zhaoli@lzu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Hematology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
authors.forename: Xiang-Xing
authors.initials: XX
authors.lastname: Liu
authors.affiliation: Department of Hematology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: Ma
mesh_terms: D002648:Child; D006801:Humans; D015122:Mercaptopurine / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013866:Thioguanine / Q000627:therapeutic use*
chemical_list: D015122:Mercaptopurine; D013866:Thioguanine