title: FADS2 genotype influences whole-body resting fat oxidation in young adult men.
abstract: Considerable evidence supports an association between fatty acid desaturase 2 (FADS2) polymorphisms and the efficiency of converting alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA) via the desaturation-elongation pathway. However, ALA conversion into EPA represents only 1 of the metabolic fates for this essential fatty acid, as ALA is also highly oxidized. This study demonstrates for the first time that genetic variation in FADS2 (rs174576) is not only associated with the activity of the desaturation-elongation pathway, but also whole-body fat oxidation.
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Kaitlin
authors.initials: K
authors.lastname: Roke
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Jannas-Vela
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Spriet
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: David M
authors.initials: DM
authors.lastname: Mutch
mesh_terms: D015118:Eicosapentaenoic Acid / Q000737:chemistry; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics* / Q000502:physiology*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012146:Rest / Q000502:physiology*; D055815:Young Adult; D017962:alpha-Linolenic Acid / Q000737:chemistry
chemical_list: D017962:alpha-Linolenic Acid; D015118:Eicosapentaenoic Acid; D044943:Fatty Acid Desaturases; C533241:FADS2 protein, human
keywords: SNP; acide eicosapentaénoïque; acide gras désaturase; acide linolénique; eicosapentaenoic acid; fatty acid desaturase; linolenic acid; métabolisme de repos; oxidation; oxydation; resting metabolic rate