title: Immunoglobulin G4-positive staining of orbital lesions in thyroid eye disease: Report of two cases.
abstract: We report two cases with immunoglobulin G4 (IgG4)-positive staining of orbital lesions and thyroid eye disease (TED). Case 1 was a 63-year-old male with right upper eyelid swelling due to right lacrimal gland enlargement. Case 2 was a 49-year-old male with bilateral proptosis due to multiple orbital masses. Both the biopsied right lacrimal gland in Case 1 and the orbital masses on both sides in Case 2 showed infiltration of immunoglobulin-G4-positive plasma cells.
authors.affiliation: a Department of Oculoplastic , Orbital and Lacrimal Surgery, Aichi Medical University Hospital , Nagakute , Aichi , Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: b Department of Pathology , Aichi Medical University Hospital , Nagakute , Aichi , Japan , and.
authors.forename: Emiko
authors.initials: E
authors.lastname: Takahashi
authors.affiliation: c Division of Endocrinology and Metabolism, Department of Medicine , Kurume University School of Medicine , Kurume , Fukuoka , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiromatsu
authors.affiliation: a Department of Oculoplastic , Orbital and Lacrimal Surgery, Aichi Medical University Hospital , Nagakute , Aichi , Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kakizaki
mesh_terms: D005128:Eye Diseases / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007765:Lacrimal Apparatus / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology
chemical_list: D007074:Immunoglobulin G
keywords: Histopathology; Immunoglobulin G4-related ophthalmic disease; Steroid; Thyroid eye disease