title: PTH Signaling and Epigenetic Control of Bone Remodeling.
abstract: As our understanding of the mechanisms that govern bone development advance, the role of epigenetic modifications in these processes become increasingly evident. Interestingly, in parathyroid hormone (PTH)-induced bone metabolism and remodeling, recent evidence shows that PTH signaling employs a particular facet of the epigenetic machinery to elicit its desired effects. In this review, we briefly discuss the known epigenetic events occurring in cells of the osteoblast lineage. More specifically, we elaborate on current findings that reveal the utilization of histone deacetylating enzymes (HDACs) in PTH-regulated modulation of gene expression in bone.
authors.affiliation: New York University School of Medicine, Sackler Institute of Graduate Biomedical Sciences, Department of Biochemistry and Molecular Pharmacology, New York, NY 10016.
authors.forename: Florante
authors.initials: F
authors.lastname: Ricarte
authors.affiliation: New York University College of Dentistry, Department of Basic Science and Craniofacial Biology, New York, NY 10010.
authors.forename: Teruyo
authors.initials: T
authors.lastname: Nakatani
authors.affiliation: New York University School of Medicine, Sackler Institute of Graduate Biomedical Sciences, Department of Biochemistry and Molecular Pharmacology, New York, NY 10016; New York University College of Dentistry, Department of Basic Science and Craniofacial Biology, New York, NY 10010.
authors.forename: Nicola
authors.initials: N
authors.lastname: Partridge
keywords: HDAC; PTH; bone remodeling; transcriptional regulation