title: Survival outcomes after endoscopic resection for sinonasal squamous cell carcinoma arising on inverted papilloma.
abstract: Sinonasal inverted papillomas (IPs) can be associated synchronously or metachronously to invasive squamous cell carcinoma (SCC) in 5% to 10% of cases. The purposes of the present study were to analyze the outcomes of patients with sinonasal SCC arising from inverted papilloma (IP-SCC) treated through an endoscopic approach and review the pertinent literature.
  
  
  
  The medical records of all patients treated for IP-SCC between 1997 and 2014 at 2 referral centers following a uniform policy were retrospectively analyzed.
  
  
  
  Thirty-four patients fulfilled the inclusion criteria. The 5-year overall survival (OS), disease-specific survival (DFS), and recurrence-free survival (RFS) rates were 66.8 ± 0.99%, 71.2 ± 0.96%, and 73.1 ± 0.82%, respectively. Multivariate analysis revealed that the advanced pT classification (pT3 or greater), the high-grade of tumoral differentiation, the cranioendoscopic approach, and the recurrence of disease impacted negatively on survival rates.
  
  
  
  The endoscopic approach provides encouraging oncologic outcomes for sinonasal IP-SCC, comparable to those observed with traditional external approaches while minimizing morbidity for patients. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.
authors.affiliation: Division of Otorhinolaryngology, Department of Surgical, Microsurgical, and Medical Sciences, University of Sassari, Sassari, Italy. alkis.karligkiotis@gmail.com.|Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy. alkis.karligkiotis@gmail.com.|Head and Neck Surgery & Forensic Dissection Research Center (HNS & FDRC), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy. alkis.karligkiotis@gmail.com.
authors.forename: Apostolos
authors.identifier: 0000-0003-0129-9908
authors.initials: A
authors.lastname: Karligkiotis
authors.affiliation: Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Lepera
authors.affiliation: Division of Otorhinolaryngology, Department of Surgical, Microsurgical, and Medical Sciences, University of Sassari, Sassari, Italy.|Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Volpi
authors.affiliation: Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.|Head and Neck Surgery & Forensic Dissection Research Center (HNS & FDRC), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Turri-Zanoni
authors.affiliation: Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.|Head and Neck Surgery & Forensic Dissection Research Center (HNS & FDRC), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Battaglia
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Lombardi
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Remo
authors.initials: R
authors.lastname: Accorona
authors.affiliation: Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.|Head and Neck Surgery & Forensic Dissection Research Center (HNS & FDRC), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bignami
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
authors.affiliation: Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.|Head and Neck Surgery & Forensic Dissection Research Center (HNS & FDRC), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D016609:Neoplasms, Second Primary / Q000401:mortality* / Q000601:surgery; D018308:Papilloma, Inverted; D010255:Paranasal Sinus Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate
keywords: endoscopic endonasal approach; inverted papilloma; paranasal sinuses; radiotherapy; sinonasal cancer; skull base; squamous cell carcinoma