title: Therapies to Reduce Blood Pressure Acutely.
abstract: Clinicians make frequent treatment decisions regarding acute blood pressure reduction for the critically ill. Key to the decision making process is a balance between reducing arterial wall stress and maintaining perfusion to vital organs. In this article, we review the physiological considerations underlying acute blood pressure management, including the concept of cerebral autoregulation and its adaptations to chronic hypertension. We then discuss available pharmacological interventions suited for reducing blood pressure acutely. We also discuss specific blood pressure targets in common critical illnesses and consider future directions in this therapeutic area.
authors.affiliation: Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA. jmiller6@hfhs.org.|Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA. jmiller6@hfhs.org.|Wayne State University, Detroit, MI, USA. jmiller6@hfhs.org.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Miller
authors.affiliation: Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.|Wayne State University, Detroit, MI, USA.
authors.forename: Harish
authors.initials: H
authors.lastname: Kinni
authors.affiliation: Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Amer
authors.affiliation: Department of Emergency Medicine, Wayne State University, Detroit, MI, USA.
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Levy
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D000066491:Clinical Decision-Making; D016638:Critical Illness / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents
keywords: Antihypertensive; Blood pressure; Hypertension; Hypertensive emergencies