title: Long-Term Neurodevelopmental Outcome in Survivors of Twin-to-Twin Transfusion Syndrome.
abstract: Twin-twin transfusion syndrome (TTTS) is a severe complication of monochorionic (MC) twin pregnancies associated with high perinatal mortality and morbidity rates. Management in TTTS is a major challenge for obstetricians and neonatologists. Twins with TTTS are often born prematurely after an extremely distressing and highly hazardous fetal period. Follow-up studies report varying rates of cerebral palsy (CP) and long-term neurodevelopmental impairment (NDI). This review discusses the latest findings on the long-term outcome of TTTS survivors, possible risk factors for long-term impairment, and provides recommendations for future research.
authors.affiliation: Department of Pediatrics,Division of Neonatology,Leiden University Medical Center,Leiden,the Netherlands.
authors.forename: Jeanine M M
authors.initials: JM
authors.lastname: van Klink
authors.affiliation: Faculty of Social Sciences,Clinical Psychology,Leiden University,Leiden,the Netherlands.
authors.forename: Hendrik M
authors.initials: HM
authors.lastname: Koopman
authors.affiliation: Department of Pediatrics,Division of Neonatology,Leiden University Medical Center,Leiden,the Netherlands.
authors.forename: Monique
authors.initials: M
authors.lastname: Rijken
authors.affiliation: Department of Obstetrics,Division of Fetal Medicine,Leiden University Medical Center,Leiden,the Netherlands.
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Middeldorp
authors.affiliation: Department of Obstetrics,Division of Fetal Medicine,Leiden University Medical Center,Leiden,the Netherlands.
authors.forename: Dick
authors.initials: D
authors.lastname: Oepkes
authors.affiliation: Department of Pediatrics,Division of Neonatology,Leiden University Medical Center,Leiden,the Netherlands.
authors.forename: Enrico
authors.initials: E
authors.lastname: Lopriore
mesh_terms: D002547:Cerebral Palsy / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005313:Fetal Death; D005330:Fetofetal Transfusion / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D065886:Neurodevelopmental Disorders / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D059285:Pregnancy, Twin; D017741:Survivors
keywords: amnioreduction; laser surgery; monochorionic twins; neurodevelopmental outcome; twin–twin transfusion syndrome