title: Looping around Reprogramming: The Topological Memory of Induced Pluripotency.
abstract: Genome architecture is associated with cellular identity, but how this organization changes during reprogramming is not well understood. Now in Cell Stem Cell, Krijger et al. (2016) and Beagan et al. (2016) report 3D chromatin interaction maps before and after reprogramming, providing evidence for topological memory in induced pluripotent stem cells.
authors.affiliation: Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672.
authors.forename: Kevin Andrew Uy
authors.initials: KA
authors.lastname: Gonzales
authors.affiliation: Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672; Department of Biochemistry, National University of Singapore, Singapore 117597; Department of Biological Sciences, National University of Singapore, Singapore 117597; School of Biological Sciences, Nanyang Technological University, Singapore 639798. Electronic address: nghh@gis.a-star.edu.sg.
authors.forename: Huck-Hui
authors.initials: HH
authors.lastname: Ng
mesh_terms: D065150:Cellular Reprogramming; D002843:Chromatin; D016678:Genome; D006801:Humans; D057026:Induced Pluripotent Stem Cells
chemical_list: D002843:Chromatin