title: Deriving bioconcentration factors and somatic biotransformation rates from dietary bioaccumulation and depuration tests.
abstract: The present study develops, applies, and tests a method for deriving empirical bioconcentration factors and somatic biotransformation rate constants from dietary bioaccumulation tests and simplified bioaccumulation experiments that measure depuration rates. In this approach, measurement of the chemical concentration in the water is not required. The method aims to improve bioaccumulation assessment, reduce cost and animal use, and shorten experiments. Environ Toxicol Chem 2016;35:2968-2976. © 2016 SETAC.
authors.affiliation: School of Resource and Environmental Management, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Frank A P C
authors.initials: FA
authors.lastname: Gobas
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Lo
mesh_terms: D000818:Animals; D001711:Biotransformation; D004032:Diet; D007700:Kinetics; D008962:Models, Theoretical; D017686:Oncorhynchus mykiss / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000378:metabolism*
chemical_list: D014874:Water Pollutants, Chemical
keywords: Bioaccumulation; Bioconcentration; Biotransformation; Hydrophobic chemicals; In vivo