title: Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study.
abstract: Introduction Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events. Results Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery. Conclusion The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population.
authors.affiliation: Copenhagen Centre for Cancer and Health, City of Copenhagen, Copenhagen, Denmark mss@kraeftcenter-kbh.dk.
authors.forename: Maja S
authors.initials: MS
authors.lastname: Sommer
authors.affiliation: Copenhagen Centre for Cancer and Health, City of Copenhagen, Copenhagen, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Trier
authors.affiliation: Copenhagen Centre for Cancer and Health, City of Copenhagen, Copenhagen, Denmark.
authors.forename: Jette
authors.initials: J
authors.lastname: Vibe-Petersen
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Malene
authors.initials: M
authors.lastname: Missel
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Merete
authors.initials: M
authors.lastname: Christensen
authors.affiliation: Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Klaus R
authors.initials: KR
authors.lastname: Larsen
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Seppo W
authors.initials: SW
authors.lastname: Langer
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Hendriksen
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.|Gentofte University Hospital, Hellerup, Denmark.
authors.forename: Paul Frost
authors.initials: PF
authors.lastname: Clementsen
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jesper H
authors.initials: JH
authors.lastname: Pedersen
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Henning
authors.initials: H
authors.lastname: Langberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000534:rehabilitation* / Q000601:surgery*; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000534:rehabilitation* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D059035:Perioperative Period / Q000534:rehabilitation*; D011788:Quality of Life
keywords: NSCLC; exercise; lung cancer; perioperative intervention; rehabilitation