title: Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides.
abstract: Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans' life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs.
authors.affiliation: Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea;
authors.forename: Murat
authors.initials: M
authors.lastname: Artan
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea;
authors.forename: Dae-Eun
authors.initials: DE
authors.lastname: Jeong
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea;
authors.forename: Dongyeop
authors.initials: D
authors.lastname: Lee
authors.affiliation: Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea;
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Kim
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea;
authors.forename: Heehwa G
authors.initials: HG
authors.lastname: Son
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA;
authors.forename: Zahabiya
authors.initials: Z
authors.lastname: Husain
authors.affiliation: Department of Cognitive and Brain Sciences, DGIST (Daegu Gyeongbuk Institute of Science and Technology), Daegu 42988, South Korea;
authors.forename: Jinmahn
authors.initials: J
authors.lastname: Kim
authors.affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Altintas
authors.affiliation: Department of Cognitive and Brain Sciences, DGIST (Daegu Gyeongbuk Institute of Science and Technology), Daegu 42988, South Korea;
authors.forename: Kyuhyung
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA;
authors.forename: Joy
authors.initials: J
authors.lastname: Alcedo
authors.affiliation: Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
authors.forename: Seung-Jae V
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D003463:Cues; D004777:Environment; D005502:Food; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D007328:Insulin / Q000235:genetics* / Q000378:metabolism; D008136:Longevity / Q000235:genetics*; D062308:Optogenetics; D036361:Peptide Hormones / Q000235:genetics* / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000502:physiology; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D007328:Insulin; D036361:Peptide Hormones; C108831:daf-16 protein, C elegans
keywords: C. elegans; DAF-16/FOXO; aging; insulin-like peptide; sensory neurons