title: The Influence of Selenium Yeast on Hematological, Biochemical and Reproductive Hormone Level Changes in Kunming Mice Following Acute Exposure to Zearalenone.
abstract: Healthy male Kunming mice received selenium yeast for 14 days prior to a single oral administration of zearalenone (ZEN). After 48 h, blood samples were collected for analysis and showed that mice in the ZEN-treated group has significantly decreased lymphocytes (P < 0.05) and platelets (P < 0.05) along with an increased white blood cell (WBC) count and other constituents (P < 0.05). The serum biochemistry analysis of the ZEN group indicated that glutamic pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST), urea, and uric acid were significantly increased (P < 0.05), whilst total bilirubin (TB) and albumin (ALB) were decreased along with serum testosterone and estrogen (P < 0. 05). The level of malondialdehyde (MDA) in the serum of the ZEN group was significantly increased whilst glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) had significantly decreased (P < 0.05). Treatment with selenium yeast had a significant effect on response with most of the experimental parameters returning to levels similar to those observed in the untreated control mice. From these data, it can be concluded that ZEN is highly poisonous in Kunming mice with high levels of toxicity on the blood, liver, and kidneys. High levels of oxidative stress were observed in mice and pre-treatment with selenium yeast by oral gavage is effective in the ameliorated effects of ZEN-induced damage.
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Long
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Yang
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Wenkui
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China.
authors.forename: Xinliang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China. jianbinhe69@126.com.
authors.forename: Jianbin
authors.initials: J
authors.lastname: He
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D012441:Saccharomyces cerevisiae; D012643:Selenium / Q000494:pharmacology*; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood; D015025:Zearalenone / Q000009:adverse effects* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D012739:Gonadal Steroid Hormones; D014527:Uric Acid; D008315:Malondialdehyde; D015025:Zearalenone; D014508:Urea; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D012643:Selenium; D001663:Bilirubin
keywords: Biochemical; Hematological; Oxidative stress; Reproductive hormone; Selenium yeast; Zearalenone