title: Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Nonlinearity in Tendon Tissue Mechanics.
abstract: Regenerative medicine plays a critical role in the future of medicine. However, challenges remain to balance stem cells, biomaterial scaffolds, and biochemical factors to create successful and effective scaffold designs. This project analyzes scaffold architecture with respect to mechanical capability and preliminary mesenchymal stem cell response for tendon regeneration. An electrospun fiber scaffold with tailorable properties based on a "Chinese-fingertrap" design is presented. The unique criss-crossed fiber structures demonstrate non-linear mechanical response similar to that observed in native tendon. Mechanical testing revealed that optimizing the fiber orientation resulted in the characteristic "S"-shaped curve, demonstrating a toe region and linear elastic region. This project has promising research potential across various disciplines: vascular engineering, nerve regeneration, and ligament and tendon tissue engineering.
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University, 205 Hallowell Building, University Park, PA 16802.
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Banik
authors.affiliation: Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey Medical Center, Hershey, PA 17033.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Lewis
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University, 205 Hallowell Building, University Park, PA 16802.
authors.forename: Justin L
authors.initials: JL
authors.lastname: Brown
keywords: bioinstructive scaffold; electrospinning; poly-(ϵ-caprolactone); regenerative medicine; tendon