title: Endobronchial ultrasound-guided transbronchial needle aspiration: performance of biomedical scientists on rapid on-site evaluation and preliminary diagnosis.
abstract: OBJECTIVE
  Rapid on-site evaluation (ROSE) of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) followed by a subsequent preliminary adequacy assessment and a preliminary diagnosis, was performed at Aarhus University Hospital by biomedical scientists (BMS). The aim of this study was to evaluate the BMS accuracy of ROSE adequacy assessment, the preliminary adequacy assessment and the preliminary diagnosis as compared with the cytopathologist-rendered final adequacy assessment and final diagnosis.
  
  
  METHODS
  The BMS-rendered assessments for 717 sites from 319 consecutive patients over a 4-month period were compared with the cytopathologist-rendered assessments. Comparisons of adequacy and preliminary diagnoses were based on inter-observer Cohen's Kappa coefficient with a 95% confidence interval (CI).
  
  
  RESULTS
  Strong correlations between ROSE and final adequacy assessments [Kappa coefficient of 0.90 (CI: 0.85-0.96)] and between the preliminary and final adequacy assessments [Kappa coefficient of 0.93 (CI: 0.87-0.99)] were found. As for the correlation between the preliminary and final diagnoses, the Kappa coefficient was 0.99 (CI: 0.98-1).
  
  
  CONCLUSIONS
  Both ROSE and preliminary adequacy assessments as well as preliminary diagnoses, all performed by BMS, were highly accurate when compared with the final assessment by the cytopathologist.
authors.affiliation: Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: M J
authors.initials: MJ
authors.lastname: Schacht
authors.affiliation: Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: C B
authors.initials: CB
authors.lastname: Toustrup
authors.affiliation: Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: L B
authors.initials: LB
authors.lastname: Madsen
authors.affiliation: Department of Pathology, Aarhus University Hospital, Aarhus, Denmark. marimart@rm.dk.
authors.forename: M S
authors.initials: MS
authors.lastname: Martiny
authors.affiliation: VIA University College, Aarhus, Denmark.
authors.forename: B B
authors.initials: BB
authors.lastname: Larsen
authors.affiliation: VIA University College, Aarhus, Denmark.
authors.forename: J T
authors.initials: JT
authors.lastname: Simonsen
mesh_terms: D000328:Adult; D000368:Aged; D001999:Bronchoscopy; D003581:Cytodiagnosis / Q000379:methods*; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
keywords: Endobronchial ultrasound-guided transbronchial needle aspiration; adequacy assessment; biomedical scientist; cytopathologist; preliminary diagnosis; rapid on-site evaluation