title: Too little benefit for too much toxicity: rethinking the adjuvant development model in colon cancer.
authors.affiliation: Department of Medicine, Digestive Oncology Unit, Medical Oncology, Institut Jules Bordet, ULB, Brussels, Belgium.
authors.forename: Alain
authors.initials: A
authors.lastname: Hendlisz
authors.forename: Harry
authors.initials: H
authors.lastname: Bleiberg
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D004249:DNA Damage; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D005472:Fluorouracil