title: Uveal Melanomas Harbor Recurrent Activating Mutations in CYSLTR2.
abstract: A mutation in the CYCLTR2 G-protein-coupled receptor promotes tumorigenesis in uveal melanomas.
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D018077:Receptors, Leukotriene / Q000235:genetics* / Q000378:metabolism; D014604:Uveal Neoplasms / Q000235:genetics* / Q000378:metabolism; D000098943:Uveal Melanoma
chemical_list: D015513:Oncogene Proteins; D018077:Receptors, Leukotriene; C412375:cysteinyl leukotriene receptor 2