title: Diagnostic Utility of Selective Upper Tract Urinary Cytology: A Systematic Review and Meta-analysis of the Literature.
abstract: The diagnosis of upper tract urothelial carcinoma (UTUC) can be a challenging diagnostic pursuit. To date, there is no large-scale study assessing the statistical utility (eg, sensitivity and specificity) of selective cytology. Herein, we systematically reviewed and meta-analyzed the published literature to evaluate the efficacy of selective cytology for the detection of UTUC in patients with a suspicious clinical profile Selective cytology confers a high specificity but marginal sensitivity for the detection of UTUC. The sensitivity is greater for high-grade UTUC lesions. The statistical assessment of its utility is limited by the heterogeneity and bias of previous studies.
authors.affiliation: Division of Urology, Washington University School of Medicine, Saint Louis, MO. Electronic address: potretzkea@wudosis.wustl.edu.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Potretzke
authors.affiliation: Division of Urology, Washington University School of Medicine, Saint Louis, MO.
authors.forename: B Alexander
authors.initials: BA
authors.lastname: Knight
authors.affiliation: Division of Urology, Washington University School of Medicine, Saint Louis, MO.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Vetter
authors.affiliation: Division of Urology, Washington University School of Medicine, Saint Louis, MO.
authors.forename: Barrett G
authors.initials: BG
authors.lastname: Anderson
authors.affiliation: Division of Urology, Washington University School of Medicine, Saint Louis, MO.
authors.forename: Angela C
authors.initials: AC
authors.lastname: Hardi
authors.affiliation: Division of Urology, Washington University School of Medicine, Saint Louis, MO.
authors.forename: Sam B
authors.initials: SB
authors.lastname: Bhayani
authors.affiliation: Division of Urology, Washington University School of Medicine, Saint Louis, MO.
authors.forename: R Sherburne
authors.initials: RS
authors.lastname: Figenshau
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D003581:Cytodiagnosis; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D012680:Sensitivity and Specificity; D014516:Ureteral Neoplasms / Q000473:pathology*