title: Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence.
abstract: In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination ("two-hit") on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of "two-hit" rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis.
authors.affiliation: Molecular Psychopharmacology Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia. Electronic address: rejhan.idrizi@florey.edu.au.
authors.forename: Rejhan
authors.initials: R
authors.lastname: Idrizi
authors.affiliation: Molecular Psychopharmacology Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia. Electronic address: p.malcs@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Malcolm
authors.affiliation: NeuRA, Schizophrenia Research Institute, Randwick, New South Wales, Australia; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia; Neuroscience Research Australia, Randwick, New South Wales, Australia. Electronic address: c.weickert@neura.edu.au.
authors.forename: Cynthia Shannon
authors.initials: CS
authors.lastname: Weickert
authors.affiliation: NeuRA, Schizophrenia Research Institute, Randwick, New South Wales, Australia. Electronic address: zavitsanouk@gmail.com.
authors.forename: Katerina
authors.initials: K
authors.lastname: Zavitsanou
authors.affiliation: Molecular Psychopharmacology Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia; Northern Psychiatry Research Centre, Northern Area Mental Health Servic(f)e, Epping, Victoria, Australia. Electronic address: suresh.sundram@monash.edu.
authors.lastname: Suresh Sundram
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002186:Cannabinoids / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D004195:Disease Models, Animal; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D018811:Maternal Exposure / Q000009:adverse effects; D020890:Neuregulin-1 / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D066247:Receptor, ErbB-4 / Q000378:metabolism; D012559:Schizophrenia / Q000139:chemically induced*; D015854:Up-Regulation
chemical_list: D002186:Cannabinoids; D020890:Neuregulin-1; D012333:RNA, Messenger; C483803:Egfr protein, rat; D066246:ErbB Receptors; D066247:Receptor, ErbB-4
keywords: ErbB1; Striatum; Two-hit