title: Severity of coronary artery disease in type 2 diabetes mellitus: Does the timing matter?
abstract: OBJECTIVE
  The aim of our study was to compare the angiographic changes in 53 nondiabetic patients, 54 type 2 diabetic patients of less than 5 years of duration, 41 patients with 5-10 years of diabetes, and 27 with more than 10 years of diabetic duration.
  
  
  METHODS
  In this cross-sectional study, 175 patients, who underwent coronary angiogram for the evaluation of the coronary artery disease (CAD), were recruited. Based on the angiographic findings, syntax score, vessel score, and coronary collaterals grading were analyzed. The biochemical analysis was done by using the auto analyzer.
  
  
  RESULTS
  A significant increase in the mean syntax score (p=0.019), vessel score (p=0.007), and coronary collateral grade (p=0.008) was observed in the patients with 5-10 years of diabetes when compared to those with less than 5 years of diabetic duration. There was no significant difference in the mean syntax score (p=0.979), vessel score (p=0.299), and collateral grade (p=0.842) between the patients with 5-10 years and more than 10 years of diabetes. The difference in the mean syntax score (p=0.791), vessel score (p=0.098), and collateral grade (p=0.661) between the nondiabetic and the patients with less than 5 years of diabetes was not significant.
  
  
  CONCLUSIONS
  A significant structural change in the coronary arteries was found among the patients with 5-10 years of diabetes.
authors.affiliation: PhD Research Scholar, Department of Internal Medicine, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India.
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Srinivasan
authors.affiliation: Additional Professor, Department of Cardiology, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India.
authors.forename: Padmanabh K
authors.initials: PK
authors.lastname: Kamath
authors.affiliation: Associate Professor, Department of Cardiology, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India.
authors.forename: Narayan M
authors.initials: NM
authors.lastname: Bhat
authors.affiliation: Associate Professor, Department of Cardiology, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India.
authors.forename: Narasimha D
authors.initials: ND
authors.lastname: Pai
authors.affiliation: Assistant Professor, Department of Cardiology, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India.
authors.forename: Rajesh U
authors.initials: RU
authors.lastname: Bhat
authors.affiliation: DNB Student, Department of Cardiology, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India.
authors.forename: Tejas D
authors.initials: TD
authors.lastname: Shah
authors.affiliation: Postgraduate, Department of Physiology, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India.
authors.forename: Anish
authors.initials: A
authors.lastname: Singhal
authors.affiliation: Professor, Department of Internal Medicine, Kasturba Medical College, Mangalore (A Constituent College of Manipal University), India. Electronic address: chakrapani2009@hotmail.com.
authors.forename: Chakrapani
authors.initials: C
authors.lastname: Mahabala
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
keywords: Coronary artery disease; Syntax score; Type 2 diabetes mellitus