title: Urinary Excretion Profiles of 2,5-Dimethoxy-4-alkylthiophenethylamine Analogs in Rats.
abstract: The urinary metabolic profiles of three hallucinogenic 2,5-dimethoxy-4-alkylthiophenethylamine analogs: 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2), 2,5-dimethoxy-4-isopropylthiophenethylamine (2C-T-4), and 2,5-dimethoxy-4-propylthiophenethylamine (2C-T-7), were investigated in rats. For each drug, four male Sprague-Dawley rats were orally administered 10 mg/kg of 2C-T-2, 2C-T-4, or 2C-T-7, and urine was collected 0-24 and 24-48 h after administration. The urine samples were processed by liquid-liquid extraction, and the extracts were analyzed by liquid chromatography/mass spectrometry to quantify the metabolites. The metabolic patterns of these drugs were different: for 2C-T-7, the principal metabolite was the β-hydroxylated-N-acetylated-sulfoxide, whereas for 2C-T-2 and 2C-T-4 the major metabolites were the N-acetylated-sulfoxide and S-methylated-N-acetylated-sulfoxide, respectively.
authors.affiliation: National Research Institute of Police Science.
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Kanamori
authors.forename: Kenji
authors.initials: K
authors.lastname: Kuwayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsujikawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: T Iwata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000818:Animals; D000840:Anisoles / Q000493:pharmacokinetics / Q000652:urine*; D002853:Chromatography, Liquid; D006213:Hallucinogens / Q000493:pharmacokinetics / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D010627:Phenethylamines / Q000493:pharmacokinetics / Q000652:urine*; D017207:Rats, Sprague-Dawley; D013440:Sulfides / Q000493:pharmacokinetics / Q000652:urine*
chemical_list: C490165:2,5-dimethoxy-4-ethylthiophenethylamine; C487778:2,5-dimethoxy-4-n-propylthiophenethylamine; D000840:Anisoles; D006213:Hallucinogens; D010627:Phenethylamines; D013440:Sulfides