title: Novel Salted Anionic-Cationic Polymethacrylate Polymer Blends for Sustained Release of Acidic and Basic Drugs.
abstract: BACKGROUND
  Since a unique matrix tablet formulation that independently controls the release of various drug types is in a great demand, the objective of this research was to develop a sustained release matrix tablet as a universal dosage form using a binary mixture of the salt forms of Eudragit polymers rather than their interpolyelectrolyte complexes.
  
  
  METHODS
  Tablets were prepared by wet granulation and compressed at different compression forces, depending on drug type. Dissolution tests were conducted using USP XXII rotating paddle apparatus at 50 rpm at 37°C in consecutive pH stages.
  
  
  RESULTS
  Tablets containing Ibuprofen (IB) as a model acidic drug and Metronidazole (MD) as a model basic drug showed controlled/sustained release behavior. For IB tablets containing 80% Ibuprofen and 5% (w/w) polymeric combination; the time for 50% of the drug release was about 24 hours compared to 8.5 hours for plain tablets containing 80% IB. In case of MD, the drug release extended to about 7 hours for tablets containing 80% MD and 5% (w/w) polymeric combination, compared to about 1 hour for plain tablets containing 80% MD. In terms of extending the release of medications, the dissolution profiles of the tablets containing polymeric salts forms were found to be statistically superior to tablets prepared by direct compression of the polymers in their powdered base forms, and superior to tablets containing the same polymers granulated using isopropyl alcohol.
  
  
  CONCLUSIONS
  The findings indicated the significance of combining the polymers in their salt forms in controlling the release of various drug types from matrices.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box: 3030, Irbid, Jordan.
authors.forename: Wasfy M
authors.initials: WM
authors.lastname: Obeidat
authors.forename: Duaa
authors.initials: D
authors.lastname: Qasim
authors.forename: Ali
authors.initials: A
authors.lastname: Nokhodchi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Al-Jabery
authors.forename: Al-Sayed
authors.initials: AS
authors.lastname: Sallam
mesh_terms: D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D065546:Drug Liberation; D007052:Ibuprofen / Q000737:chemistry*; D008795:Metronidazole / Q000737:chemistry*; D015394:Molecular Structure; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013607:Tablets
chemical_list: D000838:Anions; D002412:Cations; D011109:Polymethacrylic Acids; D012492:Salts; D013607:Tablets; D008795:Metronidazole; C030613:polymethacrylic acid; D007052:Ibuprofen
keywords: Controlled/Sustained-Release; Metronidazole; granules; ibuprofen; pH profile; polymethacrylates