title: Developmental outcomes in cerebrospinal fluid proven enteroviral meningitis in neonates > 32 weeks of gestation.
abstract: OBJECTIVE
  The aim of this study is to assess the short-term and long-term (1 year) outcomes of cerebrospinal fluid (CSF) confirmed enteroviral meningitis in neonates > 32 weeks of gestation.
  
  
  METHODS
  A retrospective audit of neonates admitted between 1 July 2002 to 30 June 2012.
  
  
  RESULTS
  Thirty-three neonates were diagnosed with enteroviral meningitis based on a positive CSF enteroviral PCR. Physical growth and neurodevelopmental outcomes at 1 year corrected for prematurity were available for 24 infants. All infants were alive at 1 year. The median weight, length and head circumference at 1 year were in the 72nd, 62nd and 78th centile and were comparable with the birth parameters. The mean general quotient (GQ) was 98.5 (SD 7.1) and was not significantly different from the population mean of 100.2 (P = 0.27). None of the infants had a GQ > 2SD below the population mean. Neurological recovery was complete in the 24 neonates assessed except one, who developed cerebral palsy, epilepsy and progressive hydrocephalus requiring ventriculoperitoneal shunt at 1 year.
  
  
  CONCLUSIONS
  Neonatal enteroviral meningitis was associated with optimal growth and neurodevelopment in the majority of the infants at 1 year corrected for prematurity. Longer term studies are needed to better define developmental outcomes.
authors.affiliation: Department of Neonatology, Princess Margaret Hospital for Children, Perth, Australia.|Department of Neonatology, King Edward Memorial Hospital for Women, Perth, Australia.
authors.forename: Haribalakrishna
authors.initials: H
authors.lastname: Balasubramanian
authors.affiliation: Department of Neonatology, Princess Margaret Hospital for Children, Perth, Australia.|Department of Neonatology, King Edward Memorial Hospital for Women, Perth, Australia.|Centre for Neonatal Research and Education, School of Paediatrics and Child Health, The University of Western Australia, Perth, Australia.
authors.forename: Deepika
authors.initials: D
authors.lastname: Wagh
authors.affiliation: Department of Neonatology, Princess Margaret Hospital for Children, Perth, Australia.|Department of Neonatology, King Edward Memorial Hospital for Women, Perth, Australia.|Centre for Neonatal Research and Education, School of Paediatrics and Child Health, The University of Western Australia, Perth, Australia.
authors.forename: Shripada
authors.initials: S
authors.lastname: Rao
authors.affiliation: PathWest Laboratory Medicine WA, Princess Margaret Hospital for Children.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Keil
authors.affiliation: Department of Neonatology, Princess Margaret Hospital for Children, Perth, Australia.|Child Development, Princess Margaret Hospital for Children, Perth, Australia.|Department of Neonatology, King Edward Memorial Hospital for Women, Perth, Australia.
authors.forename: Judy
authors.initials: J
authors.lastname: McMichael
mesh_terms: D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D015331:Cohort Studies; D004769:Enterovirus Infections / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006128:Growth / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008297:Male; D008587:Meningitis, Viral / Q000175:diagnosis* / Q000628:therapy; D008603:Mental Health; D011247:Pregnancy; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index
keywords: enterovirus; meningitis; neonate; neurodevelopment