title: Adherens Junction and E-Cadherin complex regulation by epithelial polarity.
abstract: E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial sheets. Through the homophilic association of E-Cadherin molecules expressed on neighboring cells, they ensure intercellular adhesion amongst epithelial cells, and regulate many key aspects of epithelial biology. While their adhesive role requires these structures to remain stable, AJs are also extremely plastic. This plasticity allows for the adaptation of the cell to its changing environment: changes in neighbors after cell division, cell death, or cell movement, and changes in cell shape during differentiation. In this review we focus on the recent advances highlighting the critical role of the apico-basal polarity machinery, and in particular of the Par3/Bazooka scaffold, in the regulation and remodeling of AJs. We propose that by regulating key phosphorylation events on the core E-Cadherin complex components, Par3 and epithelial polarity promote meta-stable protein complexes governing the correct formation, localization, and functioning of AJ.
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.|IRCM, INSERM U1194, Montpellier, F-34298, France.|Université de Montpellier, Montpellier, F-34090, France.|Institut régional du Cancer de Montpellier, Montpellier, F-34298, France.
authors.forename: Peter
authors.initials: P
authors.lastname: Coopman
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France. alexandre.djiane@inserm.fr.|IRCM, INSERM U1194, Montpellier, F-34298, France. alexandre.djiane@inserm.fr.|Université de Montpellier, Montpellier, F-34090, France. alexandre.djiane@inserm.fr.|Institut régional du Cancer de Montpellier, Montpellier, F-34298, France. alexandre.djiane@inserm.fr.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Djiane
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000378:metabolism*; D051177:Catenins / Q000737:chemistry / Q000378:metabolism; D016764:Cell Polarity; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D015820:Cadherins; D051177:Catenins; D008565:Membrane Proteins; D019061:src-Family Kinases; D010744:Phosphoric Monoester Hydrolases
keywords: Adherens Junctions; E-Cadherin; Epithelial polarity; Magi scaffolds; Par3; Remodeling