title: Short-term group cognitive behavior therapy contributes to recovery from mild depression: Evidence from functional and structural MRI.
abstract: We used the functional and structural magnetic resonance imaging to explore the neural correlates of response to group cognitive behavioral therapy (CBT) in mild depression. College students with mild depressive symptoms participated in our 4-week group CBT training. The behavioral results showed that depression symptoms decreased after participation in group CBT. After the training, the gray matter volume (GMV) in the right middle frontal gyrus (MFG) increased and amplitude of low-frequency fluctuations (ALFF) decreased. In addition, GMV in the left postcentral gyrus decreased after the group CBT. Moreover, the increase of percentage change in the right MFG was positively correlated with the decrease of the Beck Depression Inventory (BDI) score, while less decrease in percentage change in the left postcentral gyrus was significantly correlated with greater decrease of BDI score. Finally, after the training, functional connectivity between the right MFG and the insula decreased, while the connectivity between the left postcentral gyrus and the parahippocampal gyrus increased. These findings suggested that short-term participation in group CBT had an effective impact on mild depression. It contributed to decreasing negative bias (salience detection for negative stimuli).
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; School of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; School of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ran
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; School of Psychology, Southwest University, Chongqing 400715, China. Electronic address: zhangql@swu.edu.cn.
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address: doctorlqh@hotmail.com.
authors.forename: QingHua
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; School of Psychology, Southwest University, Chongqing 400715, China. Electronic address: qiuj318@swu.edu.cn.
authors.forename: Jiang
authors.initials: J
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003863:Depression / Q000000981:diagnostic imaging* / Q000523:psychology / Q000628:therapy*; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011615:Psychotherapy, Group / Q000379:methods; D020127:Recovery of Function; D013997:Time Factors; D055815:Young Adult
keywords: Amplitude of Low-Frequency Fluctuation; Functional Connectivity; Gray Matter Volume; Group Cognitive Behavioral Therapy