title: International Society of Urological Pathology (ISUP) grading of prostate cancer - An ISUP consensus on contemporary grading.
abstract: The International Society of Urological Pathology (ISUP) has issued guidelines for the grading of prostate cancer based on a consensus conference held in 2014. The recommendations resulting from the 2014 consensus conference were a further development of 2005 ISUP modified Gleason grading. In the 2014 system, morphological criteria are clarified, including updated definitions of Gleason pattern 4. In addition to the continued reporting of Gleason scores, we also recommend that Gleason scores ≤6, 3 + 4 = 7, 4 + 3 = 7, 8 and 9-10, respectively, be reported as five groups, i.e. ISUP grades 1-5. This new grading system has the dual benefit of predicting patient outcome as well as facilitating patient communication.
authors.affiliation: Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.|Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Egevad
authors.affiliation: Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand.
authors.forename: Brett
authors.initials: B
authors.lastname: Delahunt
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: John R
authors.initials: JR
authors.lastname: Srigley
authors.affiliation: Aquesta Pathology and University of Queensland School of Medicine, Brisbane, Queensland, Australia.
authors.forename: Hemamali
authors.initials: H
authors.lastname: Samaratunga
mesh_terms: D003245:Consensus Statements as Topic; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D060787:Neoplasm Grading / Q000379:methods* / Q000592:standards*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012958:Societies, Scientific
keywords: Gleason grade; ISUP grade; Prostate cancer; grading