title: Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes.
abstract: Six new N [(4-aminophenyl)sulfonyl]acetamide based hydroxytriazenes have been synthesized and characterized using elemental analysis, IR, 1H NMR, 13C NMR and MASS spectral analysis. Further, their theoretical predictions for probable activities have been taken using PASS (Prediction of Activity Spectra for Substance). Although a number of activities have been predicted but specifically anti-inflammatory, antiradical, anti-diabetic activities have been experimentally validated which proves that theoretical predictions agree with the experimental results. The object of the Letter is to establish Computer Aided Drug Design (CADD) using our compounds.
authors.affiliation: Co-Ordination Chemistry Laboratory, Department of Chemistry, Mohan Lal Sukhadia University, Udaipur (Rajasthan), India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Co-Ordination Chemistry Laboratory, Department of Chemistry, Mohan Lal Sukhadia University, Udaipur (Rajasthan), India.
authors.forename: Prabhat K
authors.initials: PK
authors.lastname: Baroliya
authors.affiliation: Department of Pharmacology, B.N. Institute of Pharmaceutical Sciences, Udaipur (Rajasthan), India.
authors.forename: Amit
authors.initials: A
authors.lastname: Bhargava
authors.affiliation: Faculty of Science & Environment, Mahatma Gandhi Chitrakoot Gramodaya Vishwavidhyalaya, Chitrakoot (M.P.), India.
authors.forename: I P
authors.initials: IP
authors.lastname: Tripathi
authors.affiliation: Co-Ordination Chemistry Laboratory, Department of Chemistry, Mohan Lal Sukhadia University, Udaipur (Rajasthan), India.
authors.forename: A K
authors.initials: AK
authors.lastname: Goswami
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy*; D005609:Free Radicals / Q000037:antagonists & inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013409:Sulfacetamide / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014226:Triazenes / Q000737:chemistry / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D007004:Hypoglycemic Agents; D014226:Triazenes; D013409:Sulfacetamide; D000520:alpha-Glucosidases
keywords: Anti-diabetic activity; Anti-inflammatory activity; Anti-radical activity; Hydroxytriazenes