title: Life threatening biphasic adverse reactions to desmopressin: case report and review of the literature.
abstract: Treatment with desmopressin diacetate arginine vasopressin (DDAVP) and its withdrawal are associated with side effects. We present a rare case of severe biphasic adverse reactions induced by DDAVP and its withdrawal in a 63-year-old female patient. A lump in the left axillary region was biopsied, and she received DDAVP after surgery. The following day, she lost consciousness, with foaming at the mouth and seizures. Hypotonic encephalopathy was considered. DDAVP was ceased, and she received electrolytes. On day 1, she displayed low blood pressure and increased urine output. She received DDAVP and dopamine as well as electrolytes. The patient was ambulatory on day 7 and was discharged without brain abnormalities on MRI. In conclusion, severe hyponatremia induced by DDAVP and massive polyuria and hypovolemic shock induced by DDAVP withdrawal are life-threatening conditions. This case underlines the need to be vigilant when administering DDAVP and to monitor for any side effects.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.forename: Ruijun
authors.initials: R
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Tian
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Baojun
authors.initials: B
authors.lastname: Yu
authors.forename: Xianwen
authors.initials: X
authors.lastname: Huang
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shengyuan
authors.initials: S
authors.lastname: Su
authors.forename: Guangnian
authors.initials: G
authors.lastname: Ma
authors.forename: Kaichen
authors.initials: K
authors.lastname: Wang
mesh_terms: D003894:Deamino Arginine Vasopressin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D008875:Middle Aged; D011141:Polyuria / Q000139:chemically induced; D012769:Shock / Q000139:chemically induced
chemical_list: D003894:Deamino Arginine Vasopressin