title: [TAFRO syndrome and monoclonal gammapathy: Uncommon association!].
abstract: Castleman's disease is a lymphoproliferative disorder characterized by angiofollicular lymph node hyperplasia. Recently, a new variant of multicentric Castleman's disease has been identified in Japan called TAFRO syndrome. It is characterized by a constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction and organomegaly (TAFRO). It is usually associated with polyclonal hyperimmunoglobulinemia. Here, we report the first and unique case of TAFRO syndrome with monoclonal gammapathy.
authors.affiliation: Laboratoire de biochimie, CHU Habib Bourguiba, Sfax, Tunisie; Unité de recherche des bases moléculaires de la pathologie humaine 17ES12, faculté de médecine, Sfax, Tunisie. Electronic address: manel.naifar2@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Naifar
authors.affiliation: Unité de recherche des bases moléculaires de la pathologie humaine 17ES12, faculté de médecine, Sfax, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Messedi
authors.affiliation: Laboratoire de biochimie, CHU Habib Bourguiba, Sfax, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Elleuch
authors.affiliation: Service de médecine interne, CHU Hedi Chaker, Sfax, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Snoussi
authors.affiliation: Laboratoire d'anatomie et cytologie pathologiques, CHU Habib Bourguiba, Sfax, Tunisie.
authors.forename: N
authors.initials: N
authors.lastname: Gouiaa
authors.affiliation: Laboratoire de biochimie, CHU Habib Bourguiba, Sfax, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Turki
authors.affiliation: Laboratoire de biochimie, CHU Habib Bourguiba, Sfax, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Lahiani
authors.affiliation: Laboratoire d'anatomie et cytologie pathologiques, CHU Habib Bourguiba, Sfax, Tunisie.
authors.forename: T
authors.initials: T
authors.lastname: Boudawara
authors.affiliation: Service de médecine interne, CHU Hedi Chaker, Sfax, Tunisie.
authors.forename: Z
authors.initials: Z
authors.lastname: Bahloul
authors.affiliation: Laboratoire de biochimie, CHU Habib Bourguiba, Sfax, Tunisie; Unité de recherche des bases moléculaires de la pathologie humaine 17ES12, faculté de médecine, Sfax, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Ayedi
mesh_terms: D001797:Blood Protein Electrophoresis; D005871:Castleman Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D005334:Fever / Q000209:etiology; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D000069283:Rituximab / Q000627:therapeutic use; D013163:Splenomegaly / Q000209:etiology; D013577:Syndrome
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007166:Immunosuppressive Agents; D000069283:Rituximab
keywords: Castelman's disease; Gammapathie monoclonale; Maladie de Castelman; Monoclonal gammapathy; TAFRO syndrome