title: Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects: a review of case reports and preclinical findings.
abstract: An increasing number of novel psychoactive substances are currently available and sold as 'legal highs' or 'research chemicals' accompanied by the indication that they are 'not for human consumption'. Among those that have emerged in the last few years, methoxetamine (MXE) owes its wide popularity to its easy access on the Internet and its reputation of being a 'safe' drug. MXE is an arylcyclohexylamine with a chemical structure analogous to ketamine and phencyclidine, and similar noncompetitive glutamate N-methyl D-aspartate receptor antagonist properties. Yet, very recent preclinical data highlighted a stimulatory effect of MXE on dopamine neurotransmission within the mesolimbic pathway. The aim of this review is to provide an updated review of the behavioral and toxicological effects of MXE as well as the latest findings on its pharmacology that might explain sought effects and frequent occurrence of adverse effects. In light of the growing number of intoxications induced by MXE, knowledge of its short-term and long-term effects is urgently needed. However, the hypothetical rapid antidepressant activity of MXE suggested by its chemical analogy with ketamine and supported by recent preclinical findings deserves further investigation.
authors.affiliation: aDepartment of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari bInstitute of Neuroscience-Cagliari, National Research Council of Italy, Cagliari cDepartment of Diagnostic and Public Health, Section of Pharmacology, University of Verona, Verona, Italy.
authors.forename: Mary T
authors.initials: MT
authors.lastname: Zanda
authors.forename: Paola
authors.initials: P
authors.lastname: Fadda
authors.forename: Cristiano
authors.initials: C
authors.lastname: Chiamulera
authors.forename: Walter
authors.initials: W
authors.lastname: Fratta
authors.forename: Liana
authors.initials: L
authors.lastname: Fattore
mesh_terms: D000818:Animals; D003512:Cyclohexanones / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D003514:Cyclohexylamines / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects* / Q000494:pharmacology; D019966:Substance-Related Disorders / Q000150:complications*; D013997:Time Factors
chemical_list: D003512:Cyclohexanones; D003514:Cyclohexylamines; D013287:Illicit Drugs; D004298:Dopamine; C569113:2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone