title: Endoloops or endostapler use in laparoscopic appendectomy for acute uncomplicated and complicated appendicitis : No difference in infectious complications.
abstract: The most appropriate closure for the appendicular stump with either endoloops or an endostapler in laparoscopic appendectomy remains unclear and under debate because of limited and conflicting evidence.
  
  
  
  In a 2-month prospective, observational, resident-led nationwide cohort study, patients undergoing laparoscopic appendectomy for both uncomplicated and complicated appendicitis were analysed. Logistic regression analyses were performed for identifying the possible effect of stump closure type and other risk factors for infectious complications.
  
  
  
  Laparoscopic appendectomy for acute appendicitis was performed in 1369 patients in 62 hospitals; endoloops were used in 76.7 % and an endostapler in other patients. Median operating time was not different between endoloop and endostapler use (42.0 vs. 44.0 min, P = 0.243). A superficial surgical site infection was seen in 2.0 % after uncomplicated appendicitis and in 0.8 % after complicated appendicitis. The intra-abdominal abscess rate was 1.9 % after uncomplicated and 11.0 % after complicated appendicitis. No significant effect of stump closure type was observed for any infectious complication (OR 1.05; 95 % CI 0.625-1.766, P = 0.853) or an intra-abdominal abscess (OR OR 0.96; 95 % CI 0.523-1.768, P = 0.899). In multivariable analysis, complicated appendicitis was identified as the only independent risk factor for an intra-abdominal abscess (OR 6.26; 95 % CI 3.454-11.341, P < 0.001).
  
  
  
  The infectious complication rate is not influenced by the type of appendicular stump closure with either endoloops or an endostapler in this study. If technically feasible, closure with endoloops is advised for cost considerations.
authors.affiliation: Department of surgery, Tergooi Hospital, P.O. Box 10016, 1201 DA, Hilversum, The Netherlands. cvanrossem@tergooi.nl.
authors.forename: Charles C
authors.initials: CC
authors.lastname: van Rossem
authors.affiliation: Department of surgery, Tergooi Hospital, P.O. Box 10016, 1201 DA, Hilversum, The Netherlands.
authors.forename: Anna A W
authors.initials: AA
authors.lastname: van Geloven
authors.affiliation: Department of surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Marc H F
authors.initials: MH
authors.lastname: Schreinemacher
authors.affiliation: Department of surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Willem A
authors.initials: WA
authors.lastname: Bemelman
mesh_terms: D018784:Abdominal Abscess / Q000209:etiology; D001062:Appendectomy / Q000379:methods*; D001064:Appendicitis / Q000601:surgery*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D061646:Operative Time; D011183:Postoperative Complications; D011446:Prospective Studies; D013528:Surgical Staplers; D013530:Surgical Wound Infection / Q000209:etiology
keywords: Appendectomy; Appendicitis; Endoloop; Endostapler; Laparoscopic