title: Ischemia reperfusion injury as a modifiable therapeutic target for cardioprotection or neuroprotection in patients undergoing cardiopulmonary resuscitation.
abstract: We sought to review cellular changes that occur with reperfusion to try to understand whether ischemia-reperfusion injury (RI) is a potentially modifiable therapeutic target for cardioprotection or neuroprotection in patients undergoing cardiopulmonary resuscitation.
  
  
  
  Articles written in English and published in PubMed.
  
  
  
  Remote ischemic conditioning (RIC) involves brief episodes of non-lethal ischemia and reperfusion applied to an organ or limb distal to the heart and brain. Induction of hypothermia involves cooling an ischemic organ or body. Both have pluripotent effects that reduce the potential harm associated with RI in the heart and brain by reduced opening of the mitochondrial permeability transition pore. Recent trials of RIC and induced hypothermia did not demonstrate these treatments to be effective. Assessment of the effect of these interventions in humans to date may have been modified by use of concurrent medications including propofol.
  
  
  
  Ongoing research is necessary to assess whether reduction of RI improves patient outcomes.
authors.affiliation: University of Washington, Seattle, WA, United States.
authors.forename: Ronson J
authors.initials: RJ
authors.lastname: Madathil
authors.affiliation: University of Washington, Seattle, WA, United States.
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Hira
authors.affiliation: Medical University of Vienna, Vienna, Austria.
authors.forename: Mathias
authors.initials: M
authors.lastname: Stoeckl
authors.affiliation: Medical University of Vienna, Vienna, Austria.
authors.forename: Fritz
authors.initials: F
authors.lastname: Sterz
authors.affiliation: University of Washington, Seattle, WA, United States.
authors.forename: JoAnn Broeckel
authors.initials: JB
authors.lastname: Elrod
authors.affiliation: University of Washington, Seattle, WA, United States. Electronic address: nichol@uw.edu.
authors.forename: Graham
authors.initials: G
authors.lastname: Nichol
mesh_terms: D002545:Brain Ischemia / Q000517:prevention & control; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D019194:Ischemic Preconditioning / Q000379:methods; D019157:Ischemic Preconditioning, Myocardial; D009203:Myocardial Infarction / Q000628:therapy; D017202:Myocardial Ischemia / Q000517:prevention & control; D000066829:Neuroprotection; D058687:Out-of-Hospital Cardiac Arrest / Q000628:therapy; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*
keywords: Apoptosis; Cardiac arrest; Conditioning; Necrosis; Propofol; Reperfusion injury