title: Double Modification of Polymer End Groups through Thiolactone Chemistry.
abstract: A straightforward synthetic procedure for the double modification and polymer-polymer conjugation of telechelic polymers is performed through amine-thiol-ene conjugation. Thiolactone end-functionalized polymers are prepared via two different methods, through controlled radical polymerization of a thiolactone-containing initiator, or by modification of available end-functionalized polymers. Next, these different linear polymers are treated with a variety of amine/acrylate-combinations in a one-pot procedure, creating a library of tailored end-functionalized polymers. End group conversions are monitored via SEC, NMR, and MALDI-TOF analysis, confirming the quantitative modification after each step. Finally, this strategy is applied for the synthesis of block copolymers via polymer-polymer conjugation and the successful outcome is analyzed via LCxSEC measurements.
authors.affiliation: Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4-bis, B-9000, Ghent, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Driessen
authors.affiliation: Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4-bis, B-9000, Ghent, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Martens
authors.affiliation: Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4-bis, B-9000, Ghent, Belgium.
authors.forename: Bernhard De
authors.initials: BD
authors.lastname: Meyer
authors.affiliation: Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4-bis, B-9000, Ghent, Belgium.
authors.forename: Filip E
authors.initials: FE
authors.lastname: Du Prez
authors.affiliation: Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4-bis, B-9000, Ghent, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Espeel
mesh_terms: D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D007783:Lactones; D011108:Polymers; D013438:Sulfhydryl Compounds
keywords: amine-thiol-ene conjugation; end group functionalities; one-pot double modification; polymer-polymer conjugation