title: Age-dependency of the serum oxidative level in the senescence-accelerated mouse prone 8.
abstract: Systemic oxidative stress is considered to cause aging. In this study, to estimate the oxidative stress level in senescence-accelerated mouse prone 8 (SAMP8), we evaluated serum reactive oxygen species production and reduction capacity by measurement of Diacron-Reactive Oxygen Metabolites (d-ROM) and Biological Antioxidant Potential (BAP), respectively, with age. SAMP8 showed earlier increase of d-ROM value with age than SAM resistant 1 (SAMR1), the control strain. The BAP level was the highest in adult SAMP8, whereas SAMR1 presented the sustained BAP values between ages. These results indicate that oxidative stress in SAMP8 is higher than SAMR1. Our study is the first detailed report about d-ROM and BAP in SAMP8 and will provide useful fundamental data for future aging studies.
authors.affiliation: Department of Veterinary Pathophysiology and Animal Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hanafusa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsubone
authors.forename: Haruka
authors.initials: H
authors.lastname: Takimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamanaka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kuwahara
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000502:physiology; D005260:Female; D008136:Longevity / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000378:metabolism / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000097:blood
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species