title: Perfusion and Volume Response of Canine Brain Tumors to Stereotactic Radiosurgery and Radiotherapy.
abstract: BACKGROUND
  Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) are highly conformal, high-dose radiation treatment techniques used to treat people and dogs with brain tumors.
  
  
  OBJECTIVE
  To evaluate the response to SRS- and SRT-treated tumors using volume and perfusion variables and to measure the survival times of affected dogs.
  
  
  METHODS
  Prospective study of 34 dogs with evidence of brain tumors undergoing stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT).
  
  
  METHODS
  Computed tomography and MRI imaging were used to calculate tumor volume and perfusion at baseline, and at 3 months and 6 months after treatment. Survival analysis was performed to evaluate treatment efficacy.
  
  
  RESULTS
  Mean tumor volume significantly declined from baseline to the first recheck by -0.826 cm(3) (95% CI: -1.165, -0.487) (P < .001); this reduction was maintained at the second recheck. Blood flow and blood volume declined significantly in the tumor after treatment. Median survival was 324 days (95% CI: 292.8, 419.4), and 4 dogs survived longer than 650 days. Neither actual tumor volume (hazard ratio = 1.21, P = .19) nor the change in tumor volume from the baseline (hazard ratio = 1.38, P = .12) significantly affected the hazard of death because of the tumor.
  
  
  CONCLUSIONS
  Stereotactic radiosurgery and SRT are effective treatments for reducing tumor volume, blood flow, and blood volume. Treated dogs surviving for more than 1 year are more likely to die from other causes than of their primary brain tumor. SRS and SRT should be considered for noninvasive treatment of intracranial brain tumors.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA.
authors.forename: A L
authors.initials: AL
authors.lastname: Zwingenberger
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA.
authors.forename: R E
authors.initials: RE
authors.lastname: Pollard
authors.affiliation: Department of Public Health Sciences, School of Medicine, University of California, Davis, Sacramento, CA.
authors.forename: S L
authors.initials: SL
authors.lastname: Taylor
authors.affiliation: Department of Public Health Sciences, School of Medicine, University of California, Davis, Sacramento, CA.
authors.forename: R X
authors.initials: RX
authors.lastname: Chen
authors.affiliation: William R. Pritchard Veterinary Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA.
authors.forename: J
authors.initials: J
authors.lastname: Nunley
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA.
authors.forename: M S
authors.initials: MS
authors.lastname: Kent
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D011446:Prospective Studies; D016634:Radiosurgery / Q000662:veterinary*; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D047368:Tumor Burden / Q000528:radiation effects
keywords: Blood flow; Dog; Pituitary; Radiation