title: Analyzing Dynamic Changes of Laboratory Indexes in Patients with Acute Heart Failure Based on Retrospective Study.
abstract: Background. Changes of N-terminal probrain natriuretic peptide (NT-proBNP) have been studied whether in the long term or the short term in patients of acute heart failure (AHF); however, changes of NT-proBNP in the first five days and their association with other factors have not been investigated. Aims. To describe the dynamic changes of relevant laboratory indexes in the first five days between different outcomes of AHF patients and their associations. Methods and Results. 284 AHF with dynamic values recorded were analyzed. Changes of NT-proBNP, troponin T, and C-reactive protein were different between patients with different outcomes, with higher values in adverse group than in control group at the same time points (p < 0.05). Then, prognostic use and risk stratification of NT-proBNP were assessed by receiver-operating characteristic curve and logistic regression. NT-proBNP levels at day 3 showed the best prognostic power (area under the curve = 0.730, 95% confidence interval (CI): 0.657 to 0.794) and was an independent risk factor for adverse outcome (odds ratio, OR: 2.185, 95% CI: 1.584-3.015). Classified changes of NT-proBNP may be predictive for adverse outcomes in AHF patients. Conclusions. Sequential monitoring of laboratory indexes within the first 5 days may be helpful for management of AHF patients.
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China; School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China; Department of Medical Engineering, 401 Hospital of Chinese PLA, Qingdao 266071, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China; School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Computer Section of Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Pengjun
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xueliang
authors.initials: X
authors.lastname: Huang
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China; Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Kunlun
authors.initials: K
authors.lastname: He
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China; School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002681:China / Q000453:epidemiology; D019411:Clinical Laboratory Techniques / Q000706:statistics & numerical data; D018450:Disease Progression; D005260:Female; D006305:Health Status Indicators; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015996:Survival Rate; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein