title: Aldehyde Dehydrogenase 2 Has Cardioprotective Effects on Myocardial Ischaemia/Reperfusion Injury via Suppressing Mitophagy.
abstract: Mitophagy, a selective form of autophagy, is excessively activated in myocardial ischemia/reperfusion (I/R). The study investigated whether aldehyde dehydrogenase 2 (ALDH2) exerted its cardioprotective effect by regulating mitophagy. Myocardial infarct size and apoptosis after I/R in rats were ameliorated by Alda-1, an ALDH2 activator, and aggravated by ALDH2 inhibition. Both in I/R rats and hypoxia/reoxygenation H9C2 cells, ALDH2 activation suppressed phosphatase and tensin homolog-induced putative kinase 1 (PINK1)/Parkin expression, regulating mitophagy, by preventing 4-hydroxynonenal, reactive oxygen species and mitochondrial superoxide accumulation. Furthermore, the effect was enhanced by ALDH2 inhibition. Thus, ALDH2 may protect hearts against I/R injury by suppressing PINK1/Parkin-dependent mitophagy.
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China; Institute of Emergency and Critical Care Medicine, Shandong UniversityJinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong UniversityJinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Ji
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China; Institute of Emergency and Critical Care Medicine, Shandong UniversityJinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong UniversityJinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Shujian
authors.initials: S
authors.lastname: Wei
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University Jinan, China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Hao
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Xing
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China; Institute of Emergency and Critical Care Medicine, Shandong UniversityJinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong UniversityJinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Qiuhuan
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China; Institute of Emergency and Critical Care Medicine, Shandong UniversityJinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong UniversityJinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China; Institute of Emergency and Critical Care Medicine, Shandong UniversityJinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong UniversityJinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China; Institute of Emergency and Critical Care Medicine, Shandong UniversityJinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong UniversityJinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Chen
keywords: ALDH2; Alda-1; PINK1/Parkin; mitochondrial superoxide; mitophagy; myocardial ischemia/reperfusion; reactive oxygen species