title: Naringin suppresses the development of glioblastoma by inhibiting FAK activity.
abstract: As the most common and lethal primary malignant brain cancer, glioblastoma is hard to timely diagnose and sensitive therapeutic monitoring. It is essential to develop new and effective drugs for glioblastoma multiform. Naringin belongs to citrus flavonoids and was found to display strong anti-inflammatory, antioxidant and antitumor activities. In this report, we found that naringin can specifically inhibit the kinase activity of FAK and suppress the FAKp-Try397and its downstream pathway in glioblastoma cells. Our study showed out that naringin can inhibit cell proliferation by inhibiting FAK/cyclin D1 pathway, promote cell apoptosis through influencing FAK/bads pathway, at the same time, it can also inhibit cell invasion and metastasis by inhibiting the FAK/mmps pathway. All these showed that naringin exerts the anti-tumor effects in U87 MG by inhibiting the kinase activity of FAK.
authors.affiliation: a Institute of Neurology, General Hospital of Shenyang Military Area Command , Shenyang , Liaoning , China.
authors.forename: Jinjiang
authors.initials: J
authors.lastname: Li
authors.affiliation: a Institute of Neurology, General Hospital of Shenyang Military Area Command , Shenyang , Liaoning , China.
authors.forename: Yushu
authors.initials: Y
authors.lastname: Dong
authors.affiliation: a Institute of Neurology, General Hospital of Shenyang Military Area Command , Shenyang , Liaoning , China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Hao
authors.affiliation: b Department of Neurosurgery , Tangdu Hospital, the Fourth Military Medical University , Xi'an , Shaanxi , China.
authors.forename: Bao
authors.initials: B
authors.lastname: Wang
authors.affiliation: b Department of Neurosurgery , Tangdu Hospital, the Fourth Military Medical University , Xi'an , Shaanxi , China.
authors.forename: Julei
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Institute of Neurology, General Hospital of Shenyang Military Area Command , Shenyang , Liaoning , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: a Institute of Neurology, General Hospital of Shenyang Military Area Command , Shenyang , Liaoning , China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Institute of Neurology, General Hospital of Shenyang Military Area Command , Shenyang , Liaoning , China.
authors.forename: Endi
authors.initials: E
authors.lastname: Zhen
authors.affiliation: b Department of Neurosurgery , Tangdu Hospital, the Fourth Military Medical University , Xi'an , Shaanxi , China.
authors.forename: Dayun
authors.initials: D
authors.lastname: Feng
authors.affiliation: a Institute of Neurology, General Hospital of Shenyang Military Area Command , Shenyang , Liaoning , China.
authors.forename: Guobiao
authors.initials: G
authors.lastname: Liang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000201:enzymology / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D005909:Glioblastoma / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D015394:Molecular Structure; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D044950:Flavanones; D047428:Protein Kinase Inhibitors; D051416:Focal Adhesion Protein-Tyrosine Kinases; C005274:naringin
keywords: FAK; glioblastoma; metastasis; naringin; proliferation