title: Investigation of maternal and cord blood erythropoietin and copeptin levels in low-risk term deliveries complicated by meconium-stained amniotic fluid.
abstract: OBJECTIVE
  To compare maternal, cord blood erythropoietin (EPO), and copeptin levels in low-risk term deliveries which are complicated by meconium-stained amniotic fluid (MSAF) to those with clear amniotic fluid. Also, to evaluate the relations between these markers and cord blood pH values.
  
  
  METHODS
  Low-risk term pregnant women with MSAF at an active phase of labor were defined as the study group (n = 39). Pregnant women with clear amniotic fluid were selected for the control group (n = 41). The two groups were matched for age, body mass index and gestational age. Maternal, cord blood EPO and copeptin levels with cord blood pH values were also measured.
  
  
  RESULTS
  Maternal, cord blood EPO, and copeptin levels of study and control groups were 42.6 ± 9.0 versus 40.7 ± 9.2, 134.2 (20.5-834.6) versus 38.4 (10.3-114.2), 4.9 (0.1-31.1) versus 4.0 (3.1-28.4), and 4.7 (2.6-25.5) versus 3.6 (2.0-23.2), respectively. The differences were statistically significant for cord blood EPO, maternal and cord blood copeptin levels (p < 0.001, p = 0.004, p < 0.001, respectively). The study group had a statistically and significantly lower cord blood pH values (7.25 ± 0.05 versus 7.34 ± 0.04, p < 0.001). Moreover, cord blood EPO and maternal and cord blood copeptin levels were inversely correlated with cord blood pH values in the study group (p < 0.001, p = 0.005, and p = 0.009, respectively).
  
  
  CONCLUSIONS
  We suggest that higher cord blood EPO and maternal and cord blood copeptin levels may be an indicator of fetal acidosis in low-risk term deliveries complicated by MSAF.
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Timur
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Selen
authors.initials: S
authors.lastname: Taflan
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Hançerlioğullari
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Bergen
authors.initials: B
authors.lastname: Laleli
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: İnal
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Moraloğlu
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danişman
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008470:Meconium; D011247:Pregnancy; D011248:Pregnancy Complications; D012307:Risk Factors; D018709:Statistics, Nonparametric; D047929:Term Birth / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins; D004921:Erythropoietin
keywords: Acidosis; copeptin; erythropoietin; fetal hypoxia; meconium