title: Synthesis and Anticancer Study of Novel 4H-Chromen Derivatives.
abstract: OBJECTIVE
  A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities were evaluated in vitro.
  
  
  RESULTS
  Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma cell line (U2OS) and A16 displayed the most potent antiproliferative activity against human melanoma cancer cell line (A375) in vitro, which was valuable to study further.
authors.affiliation: Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing 210009, China.
authors.forename: Gaochao
authors.initials: G
authors.lastname: Dong
authors.affiliation: Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Natural Medicines, China Pharmaceutical University, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Natural Medicines, China Pharmaceutical University, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Lua
authors.affiliation: Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans
keywords: 4H-Chromen-4-one; BRAF (V600E) kinase; anticancer activity; design; in vitro; synthesis