title: MENA Promotes Tumor-Intrinsic Metastasis through ECM Remodeling and Haptotaxis.
abstract: Oudin and colleagues report a novel and specific function of MENA in mediating directional migration of breast cancer cells toward a fibronectin gradient of increasing concentration. This MENA-mediated haptotactic response depends on the binding of MENA to the α5β1 integrin receptor, adhesion protein signaling, and fibronectin fibrillogenesis. Cancer Discov; 6(5); 474-6. ©2016 AACRSee related article by Oudin et al., p. 516.
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, California. Moores Cancer Center, University of California, San Diego, La Jolla, California. jiyang@ucsd.edu misantiagomedina@ucsd.edu.
authors.forename: Miguel
authors.initials: M
authors.lastname: Santiago-Medina
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, California. Moores Cancer Center, University of California, San Diego, La Jolla, California. Department of Pediatrics, University of California, San Diego, La Jolla, California. jiyang@ucsd.edu misantiagomedina@ucsd.edu.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
mesh_terms: D002448:Cell Adhesion; D002465:Cell Movement; D002633:Chemotaxis; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism; D009369:Neoplasms; D015398:Signal Transduction
chemical_list: D005353:Fibronectins; D039081:Integrin alpha5beta1