title: Inflammatory Inhibitory Activity of Sesquiterpenoids from Atractylodes macrocephala Rhizomes.
abstract: Three new sesquiterpenoids, 13-hydroxyl-atractylenolide II (1), 4-ketone-atractylenolide III (2), and eudesm-4(15)-ene-7β,11-diol (3), along with eleven known compounds (4-14), were isolated from the rhizomes of Atractylodes macrocephala. The structures and relative configurations of 1-3 were determined by analysis of the spectroscopic data, and the absolute configurations of 1 and 2 were assigned by circular dichroism technique. The anti-inflammatory activities of these isolates were evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cells; compounds 4, 7, and 8 exhibited moderate efficacy with IC50 values of 48.6±0.5, 46.4±3.2, and 32.3±2.9 µM, respectively.
authors.affiliation: College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu.
authors.forename: Le Son
authors.initials: le S
authors.lastname: Hoang
authors.forename: Manh Hung
authors.initials: MH
authors.lastname: Tran
authors.forename: Joo-Sang
authors.initials: JS
authors.lastname: Lee
authors.forename: Quynh Mai Thi
authors.initials: QM
authors.lastname: Ngo
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000378:metabolism* / Q000517:prevention & control; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide