title: Hawaii natural compounds are promising to reduce ovarian cancer deaths.
abstract: The low survival rate of patients with ovarian cancer largely results from the advanced ovarian tumors as well as tumor resistance to chemotherapy, leading to metastasis and recurrence. However, it is missing as to an effective therapeutic approach that focuses on these aspects to prolong progression-free survival and to decrease mortality in ovarian cancer patients. Here, based on our cancer drug discovery studies, we provide prospective insights into the development of a future line of drugs to effectively reduce ovarian cancer deaths. Pathways that increase the probability of cancer, such as the defective Fanconi anemia (FA) pathway, may render cancer cells more sensitive to new drug targeting.
authors.affiliation: a Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , Honolulu , HI , USA.|b Punahou High School , Honolulu , HI , USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Fei-Zhang
authors.affiliation: a Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , Honolulu , HI , USA.|c Department of Pharmaceutical Sciences , Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo , Hilo , HI , USA.
authors.forename: Chunshun
authors.initials: C
authors.lastname: Li
authors.affiliation: a Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center , Honolulu , HI , USA.|c Department of Pharmaceutical Sciences , Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo , Hilo , HI , USA.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
mesh_terms: D001688:Biological Products / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005260:Female; D006254:Hawaii; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: D001688:Biological Products
keywords: FA; fungi; hawaii; natural products; ovarian cancer