title: Cáncer colorrectal en los jóvenes: factores pronósticos y características clínico patológicas en un instituto del cáncer de Perú.
abstract: OBJECTIVE
  To determine clinicopathological features and prognostic factors among young colorectal cancer (CRC) patients in a Peruvian Cancer Institute.
  
  
  METHODS
  Data of patients 40 years or younger, admitted between January 2005 and December 2010, were analyzed.
  
  
  RESULTS
  During the study period, 196 young patients with CRC were admitted. The tumor was located in the rectum, left colon and right colon in 45.9%, 28.6% and 25.5% of cases. Family history of CRC was found in 13.2% and an autosomal pattern of inheritance, in 8.6% of the cases. The most common symptoms were pain (67.9%) and bleeding (67.3%). The majority (63.1%) of colon cancer cases and more than a third (34.4%) of rectal cancer cases were diagnosed in stage III or IV. The histologic type was tubular, mucinous and signet ring cell adenocarcinoma in 73.5%, 14.8% and 8.6%, respectively. The depth of invasion was T3 in 21.4% and T4 in 53%. Nodal involvement was detected in 44.5%. Five-year overall survival (OS) was 44.3%. In the multivariate analysis, only the stage resulted an independent prognostic factor for survival.
  
  
  CONCLUSIONS
  CRC in Peruvian young patients is mostly sporadic. It presents more often in the distal colon or rectum and at advanced stages of the disease. Mucinous and signet ring cell carcinoma were requent histological types. Five-year OS stage by stage is similar to that reported in the literature for older patients. Stage was the only independent prognostic factor for survival.
authors.affiliation: Departamento de Oncología Médica. Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
authors.forename: Rossana
authors.initials: R
authors.lastname: Ruiz
authors.affiliation: Departamento de Patología. Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
authors.forename: Luis
authors.initials: L
authors.lastname: Taxa
authors.affiliation: Facultad de Medicina. Universidad Peruana Cayetano Heredia, Lima, Perú.
authors.forename: Eloy F
authors.initials: EF
authors.lastname: Ruiz
authors.affiliation: Dirección de Educación, Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Raúl
authors.initials: R
authors.lastname: Mantilla
authors.affiliation: Departamento de Oncología Médica. Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
authors.forename: Luis
authors.initials: L
authors.lastname: Casanova
authors.affiliation: Departamento de Oncología Médica. Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
authors.forename: Paola
authors.initials: P
authors.lastname: Montenegro
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D000293:Adolescent; D000328:Adult; D002648:Child; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D010568:Peru; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult