title: AEG-1 as a predictor of sensitivity to neoadjuvant chemotherapy in advanced epithelial ovarian cancer.
abstract: OBJECTIVE
  Astrocyte elevated gene-1 (AEG-1) plays a critical role in tumor progression and chemoresistance. The aim of the present study was to investigate the protein expression of AEG-1 in patients with epithelial ovarian cancer (EOC) who underwent debulking surgery after neoadjuvant chemotherapy (NAC).
  
  
  METHODS
  The protein expression of AEG-1 was analyzed using immunohistochemistry in 162 patients with EOC. The relationship between AEG-1 expression and chemotherapy resistance was assessed using univariate and multivariate logistic regression analyses with covariate adjustments.
  
  
  RESULTS
  High AEG-1 expression was significantly associated with the International Federation of Gynecology and Obstetrics stage, age, serum cancer antigen-125 concentration, histological grade, the presence of residual tumor after the interval debulking surgery, and lymph node metastasis. Furthermore, AEG-1 expression was significantly higher in NAC-resistant disease than in NAC-sensitive disease (P<0.05). Multivariate analyses indicated that elevated AEG-1 expression predicted poor survival.
  
  
  CONCLUSIONS
  Our findings indicate that AEG-1 may be a potential new biomarker for predicting chemoresistance and poor prognoses in patients with EOC.
authors.affiliation: Department of Gynecology and Obstetrics, The General Hospital of Daqing Oil Field, Daqing, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Intensive Care Unit, The General Hospital of Daqing Oil Field, Daqing, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Pathology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Fanling
authors.initials: F
authors.lastname: Meng
keywords: AEG-1; epithelial ovarian cancer; interval debulking surgery; neoadjuvant chemotherapy