title: Effect of thyroid autoimmunity per se on assisted reproduction treatment outcomes: A meta-analysis.
abstract: OBJECTIVE
  Thyroid autoimmunity (TA) is the most prevalent autoimmune disease in women of reproductive age and is often accompanied by subclinical hypothyroidism (SCH). Both TA and SCH have been associated with adverse pregnancy outcomes, but their relative influence is unclear. Therefore, we carried out a meta-analysis to evaluate the sole effect of TA on pregnancy outcomes in euthyroid women undergoing assisted reproductive technology.
  
  
  METHODS
  Literature searches were conducted on Pubmed, EMBASE, and the Cochrane Controlled Trials Register Database from inception to May 2014.
  
  
  RESULTS
  In euthyroid women whose SCH status is unknown, those with positive antithyroid antibodies (ATA) had a higher miscarriage rate [pooled relative risk (RR) = 1.638; 95% confidence interval (CI), 1.228-2.185] and a lower delivery rate (pooled RR = 0.856; 95% CI, 0.759-0.965) than those with negative ATA. Clinical pregnancy rates were similar between groups. However, clinical pregnancy rate, miscarriage rate, and delivery rate were all comparable between ATA-positive and ATA-negative euthyroid women without SCH.
  
  
  CONCLUSIONS
  TA per se does not impair assisted reproductive treatment outcomes in women without SCH.
authors.affiliation: Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.affiliation: Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Jing
authors.affiliation: Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China; Reproductive Center, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410078, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gong
authors.affiliation: Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China; Reproductive Center, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410078, China.
authors.forename: Yue Qiu
authors.initials: YQ
authors.lastname: Tan
authors.affiliation: Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China; Reproductive Center, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410078, China.
authors.forename: Guang Xiu
authors.initials: GX
authors.lastname: Lu
authors.affiliation: Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China; Reproductive Center, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410078, China. Electronic address: linggf@hotmail.com.
authors.forename: Ge
authors.initials: G
authors.lastname: Lin
mesh_terms: D000022:Abortion, Spontaneous; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000276:immunology*; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D013959:Thyroid Diseases / Q000097:blood / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies
keywords: assisted reproductive treatment; meta-analysis; pregnancy outcomes; thyroid autoimmunity