title: Fc-fusion mimetics.
abstract: The Fc-fusion mimetic RpR 2[combining low line] was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR 2[combining low line] displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. h.khalil@uel.ac.uk steve.brocchini@ucl.ac.uk.
authors.forename: H
authors.initials: H
authors.lastname: Khalili
authors.forename: P T
authors.initials: PT
authors.lastname: Khaw
authors.forename: S
authors.initials: S
authors.lastname: Brocchini
mesh_terms: D004220:Disulfides / Q000737:chemistry; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry; D011485:Protein Binding / Q000276:immunology; D055503:Protein Multimerization; D040262:Receptors, Vascular Endothelial Growth Factor / Q000737:chemistry* / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000737:chemistry* / Q000276:immunology*; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology*
chemical_list: D004220:Disulfides; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D011993:Recombinant Fusion Proteins; D042461:Vascular Endothelial Growth Factor A; C533178:aflibercept; D011092:Polyethylene Glycols; D040262:Receptors, Vascular Endothelial Growth Factor