title: Variation of glucose tolerance in adult patients with cystic fibrosis: What is the potential contribution of insulin sensitivity?
abstract: Reduced insulin secretion is a key factor to explain high prevalence of glucose intolerance in patients with cystic fibrosis (CF). However, the role of insulin sensitivity remains unclear. The aim of this study is to investigate the association of insulin secretion and sensitivity with the evolution of glucose tolerance.
  
  
  
  A total of 152 patients without known diabetes from the Montreal CF cohort underwent two 2-h oral glucose tolerance tests (OGTT) at baseline and again after 21.2±5.5months. Pulmonary function and anthropometric measurements were also collected at each visit. At both visits, based on their OGTT results, patients were categorized in glucose tolerance groups (normal glucose tolerance, impaired glucose tolerance or CF-related diabetes) and stratified in 3 groups according to the variation of their glucose tolerance: stable, improved or deteriorated.
  
  
  
  At baseline, patients in the deteriorated group had a better sensitivity to insulin than those in the improved group (P=0.029). At follow-up glucose tolerance remained stable in 55.3%, improved in 14.5% and deteriorated in 30.3% of patients. During follow-up, insulin secretion remained stable in all 3 groups. While insulin sensitivity remained stable in patients without changes in glucose tolerance it worsened in patients who deteriorated glucose tolerance (P<0.001) and improved in patients who improved their glucose tolerance (P=0.003).
  
  
  
  In a context of significantly reduced insulin secretion, variations of insulin sensitivity are associated with variations of glucose tolerance in adult patients with CF.
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, Canada. Electronic address: valerie.boudreau@ircm.qc.ca.
authors.forename: Valérie
authors.initials: V
authors.lastname: Boudreau
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, Canada. Electronic address: adele.coriati@ircm.qc.ca.
authors.forename: Adèle
authors.initials: A
authors.lastname: Coriati
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, Canada. Electronic address: imane.hammana.chum@ssss.gouv.qc.ca.
authors.forename: Imane
authors.initials: I
authors.lastname: Hammana
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, Canada. Electronic address: sophie.1.ziai@gmail.com.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ziai
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, Canada. Electronic address: katherine.desjardins@ircm.qc.ca.
authors.forename: Katherine
authors.initials: K
authors.lastname: Desjardins
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Cystic Fibrosis Clinic, Centre Hospitalier de l'Université de Montréal (CHUM)-Hôtel-Dieu, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address: yves.berthiaume@ircm.qc.ca.
authors.forename: Yves
authors.initials: Y
authors.lastname: Berthiaume
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, Canada; Cystic Fibrosis Clinic, Centre Hospitalier de l'Université de Montréal (CHUM)-Hôtel-Dieu, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address: remi.rabasa-lhoret@ircm.qc.ca.
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002170:Canada / Q000453:epidemiology; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007328:Insulin / Q000032:analysis / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D013223:Statistics as Topic
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Adult; CFRD; Cystic fibrosis; Insulin sensitivity; Oral glucose tolerance test