title: Characterization of tumor and adjacent peritumoral stroma in patients with breast cancer using high-resolution diffusion-weighted imaging: Correlation with pathologic biomarkers.
abstract: OBJECTIVE
  To assess whether ADC values of tumor and peritumoral stroma (PS) obtained on high-resolution diffusion-weighted imaging (HR DWI) were different according to pathologic biomarkers in patients with breast cancer.
  
  
  METHODS
  We retrospectively enrolled 96 patients (age range, 30-75 years; mean, 52 years) with breast cancer who underwent HR DWI at 3T MR scanner. We obtained the apparent diffusion coefficient (ADC) and ADC range of tumor and PS by drawing the region of interest (ROI) of entire tumor. We assessed histopathological features of tumors. ADC values of tumor and PS were compared according to pathologic biomarkers using student t-test and Mann-Whitney U test.
  
  
  RESULTS
  Mean ADC of tumor boundary was significantly higher in ER-negative tumors than in ER-positive tumors (P=0.005). The ADC ranges of tumor boundary and proximal PS were significantly higher in tumors with high nuclear grade, negative ER, positive HER2, positive Ki67, and lymph node metastasis than those with low nuclear grade, positive ER, negative HER2, negative Ki67, and without lymph node metastasis (P<0.05 for all). ADC range of tumor boundary and proximal PS was significantly lower in low risk tumor than in the others (P=0.004 and 0.002). Mean ADC of whole tumor was significantly higher in low-risk tumor than in non-low-risk tumor (P=0.030).
  
  
  CONCLUSIONS
  On HR DWI, ADC ranges of tumor boundary and adjacent proximal PS were significantly lower in low-risk tumor than in non-low-risk tumors.
authors.affiliation: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, South Korea. Electronic address: docshin@amc.seoul.kr.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Shin
authors.affiliation: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, South Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Park
authors.affiliation: Department of Radiology and Research Institute of Radiology, Medical Imaging Laboratory, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul138-736, South Korea.
authors.forename: Ki Chang
authors.initials: KC
authors.lastname: Shin
authors.affiliation: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, South Korea.
authors.forename: Hak Hee
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, South Korea.
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Cha
authors.affiliation: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, South Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Chae
authors.affiliation: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, South Korea.
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Choi
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D000071960:Breast Carcinoma In Situ / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor
keywords: Apparent diffusion coefficient; Breast neoplasm; Diffusion-weighted imaging; Peritumoral stroma