title: On-demand Modafinil Improves Ejaculation Time and Patient-reported Outcomes in Men With Lifelong Premature Ejaculation.
abstract: To evaluate the effects of modafinil on the intravaginal ejaculatory latency time (IELT) and patient-reported outcomes in patients with lifelong premature ejaculation (PE).
  
  
  
  Treatment-naïve lifelong PE patients were included in this proof-of-concept study. Self-estimated IELTs of the patients were recorded and the Premature Ejaculation Profile (PEP) questionnaire was administered before the initiation of on-demand modafinil 100 mg treatment. At the end of 1 month of treatment, self-estimated IELTs were recorded again, along with posttreatment PEP outcomes.
  
  
  
  Overall, 55 lifelong PE patients with a mean age of 35.07 ± 7.80 (range: 22-58) years were enrolled. Modafinil treatment modestly increased the mean IELT at the end of 1 month (24.82 ± 16.10 seconds vs 49.82 ± 31.46 seconds, P = .0001). Moreover, at the end of 1 month, patients reported in the PEP questionnaire better control over ejaculation (0.75 ± 0.67 vs 1.35 ± 0.91, P = .0001), improved satisfaction with sexual intercourse (0.98 ± 0.78 vs 1.40 ± 0.85, P = .0001), lesser personal distress (0.42 ± 0.69 vs 0.89 ± 1.01, P = .0001), and reduced interpersonal difficulty (1.69 ± 1.48 vs 1.95 ± 1.47, P = .0001).
  
  
  
  In an uncontrolled proof-of-concept study of men with treatment-naïve lifelong PE where IELT was self-reported without a stopwatch, modest improvements of both IELT and patient-reported outcome measures were observed. Future controlled clinical trials are necessary to confirm these findings.
authors.affiliation: Department of Urology, Bagcilar Training & Research Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Tuken
authors.affiliation: Department of Urology, Medipol University School of Medicine, Istanbul, Turkey.
authors.forename: Murat Can
authors.initials: MC
authors.lastname: Kiremit
authors.affiliation: Department of Urology, Bagcilar Training & Research Hospital, Istanbul, Turkey. Electronic address: egecanserefoglu@hotmail.com.
authors.forename: Ege Can
authors.initials: EC
authors.lastname: Serefoglu
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D059026:Diagnostic Self Evaluation; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077408:Modafinil; D000071066:Patient Reported Outcome Measures; D061686:Premature Ejaculation / Q000188:drug therapy*; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D001559:Benzhydryl Compounds; D000077408:Modafinil