title: Tuberous Sclerosis with Severe Cutaneous Manifestation and Multiples Facial Angiofibromas.
abstract: Tuberous sclerosis is an extremely variable disease that can affect virtually any organ in the body. The most common findings are cutaneous manifestations, that are critical features in helping to establish diagnosis. We present a case of young man with diagnosis of tuberous sclerosis presenting multiple shagreen patches around the trunk, in the neck and genital region; large plaques with uneven surfaces on the right side of the lower back; and multiple papular lesions in his face, particularly around the nasolabial region, eyebrows and forehead. Considering that tuberous sclerosis is a disease with a highly variable clinical presentation, thus dentists and doctors should be aware of the different manifestations that may be found.
authors.affiliation: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil. natggalvao@hotmail.com.
authors.forename: Natália Galvão
authors.initials: NG
authors.lastname: Garcia
authors.affiliation: Department of Clinic and Surgery, Area Stomatology, Alfenas Federal University, Alfenas, Minas Gerais, Brazil.
authors.forename: Marina Lara
authors.initials: ML
authors.lastname: de Carli
authors.affiliation: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.
authors.forename: Denise Tostes
authors.initials: DT
authors.lastname: Oliveira
authors.affiliation: Department of Pathology, Lauro de Souza Lima Institute, Bauru, São Paulo, Brazil.
authors.forename: Cléverson Teixeira
authors.initials: CT
authors.lastname: Soares
authors.affiliation: Department of Clinic and Surgery, Area Stomatology, Alfenas Federal University, Alfenas, Minas Gerais, Brazil.
authors.forename: Noé Vital
authors.initials: NV
authors.lastname: Ribeiro Júnior
authors.affiliation: Department of Clinic and Surgery, Area Stomatology, Alfenas Federal University, Alfenas, Minas Gerais, Brazil.
authors.forename: Felipe Fornias
authors.initials: FF
authors.lastname: Sperandio
authors.affiliation: Department of Clinic and Surgery, Area Stomatology, Alfenas Federal University, Alfenas, Minas Gerais, Brazil.
authors.forename: João Adolfo Costa
authors.initials: JA
authors.lastname: Hanemann
mesh_terms: D018322:Angiofibroma / Q000209:etiology / Q000473:pathology*; D005145:Face / Q000473:pathology; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*; D014402:Tuberous Sclerosis / Q000150:complications* / Q000473:pathology*; D055815:Young Adult
keywords: Critical features; Cutaneous manifestations; Tuberous sclerosis