title: Genetic variants associated with physical and mental characteristics of the elite athletes in the Polish population.
abstract: The aim of the study was to assess whether selected genetic variants are associated with elite athlete performance in a group of 413 elite athletes and 451 sedentary controls. Polymorphisms in ACE, ACTN3, AGT, NRF-2, PGC1A, PPARG, and TFAM implicated in physical performance traits were analyzed. Additionally, polymorphisms in CHRNB3 and FAAH coding for proteins modulating activity of brain's emotion centers were included. The results of univariate analyses indicated that the elite athletic performance is associated with four polymorphisms: ACE (rs4341, P = 0.0095), NRF-2 (rs12594956, P = 0.011), TFAM (rs2306604, P = 0.049), and FAAH (rs324420, P = 0.0041). The multivariate analysis adjusted for age and gender confirmed this association. The higher number of ACE D alleles (P = 0.0021) and the presence of NRF-2 rs12594956 A allele (P = 0.0067) are positive predictors, whereas TFAM rs2306604 GG genotype (P = 0.031) and FAAH rs324420 AA genotype (P = 0.0084) negatively affect the elite athletic performance. The CHRNB3 variant (rs4950, G allele) is significantly more frequent in the endurance athletes compared with the power ones (P = 0.025). Multivariate analysis demonstrated that the presence of rs4950 G allele contributes to endurance performance (P = 0.0047). Our results suggest that genetic inheritance of psychological traits should be taken into consideration while trying to decipher a genetic profile of top athletic performance.
authors.affiliation: Laboratory of Neurogenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Peplonska
authors.affiliation: Department of Sport's Theory, Jozef Pilsudski University of Physical Education in Warsaw, Warszawa, Poland.|Department of Rehabilitation, Physiotherapy Division, Medical University of Warsaw, Warszawa, Poland.
authors.forename: J G
authors.initials: JG
authors.lastname: Adamczyk
authors.affiliation: Department of Sport's Theory, Jozef Pilsudski University of Physical Education in Warsaw, Warszawa, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Siewierski
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Safranow
authors.affiliation: Laboratory of Neurogenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland.|Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Maruszak
authors.affiliation: Department of Sport's Theory, Jozef Pilsudski University of Physical Education in Warsaw, Warszawa, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sozanski
authors.affiliation: Department of Sport's Theory, Jozef Pilsudski University of Physical Education in Warsaw, Warszawa, Poland.
authors.forename: A K
authors.initials: AK
authors.lastname: Gajewski
authors.affiliation: Department of Sport's Theory, Jozef Pilsudski University of Physical Education in Warsaw, Warszawa, Poland.
authors.forename: C
authors.initials: C
authors.lastname: Zekanowski
mesh_terms: D000328:Adult; D000483:Alleles; D000581:Amidohydrolases / Q000235:genetics; D056352:Athletes; D054874:Athletic Performance; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics; D051267:NF-E2-Related Factor 2 / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011044:Poland; D011110:Polymorphism, Genetic; D011978:Receptors, Nicotinic / Q000235:genetics; D013177:Sports; D014157:Transcription Factors / Q000235:genetics; D055815:Young Adult; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D004268:DNA-Binding Proteins; D024101:Mitochondrial Proteins; D051267:NF-E2-Related Factor 2; D007703:Peptidyl-Dipeptidase A; D011978:Receptors, Nicotinic; D014157:Transcription Factors; D000099252:Fatty Acid Amide Hydrolases; C539371:CHRNB3 protein, human; C495635:NFE2L2 protein, human; C499631:TFAM protein, human; C488034:ACE protein, human
keywords: Polymorphisms; endurance athletes; power athletes; psychological traits