title: Serotonin Transporter and COMT Polymorphisms as Independent Predictors of Health-related Quality of Life in Patients with Panic Disorder.
abstract: There is growing evidence of poor health-related quality of life (HRQOL) in patients with panic disorder (PD). However, little is known about the factors affecting HRQOL in patients with PD. The authors examined whether 5-HTTLPR tri-allelic approach and Cathechol-O-methyltransferase (COMT) Val(158)Met polymorphism can predict HRQOL in patients with PD controlling for sociodemographic factors and disorder-related symptom levels. The sample consisted of 179 patients with PD consecutively recruited from an outpatient clinic and age- and gender ratio-matched 110 healthy controls. The SF-36 was used to assess multiple domains of HRQOL. Hierarchical multiple regression analysis was performed to determine the independent effect of the 5-HTTLPR and COMT Val(158)Met on the SF-36 in panic patients. Patients with PD showed lowered HRQOL in all sub-domains of the SF-36 compared to healthy controls. The 5-HTTLPR independently and additively accounted for 2.2% of variation (6.7% of inherited variance) of perceived general health and the COMT Val(158)Met independently and additively accounted for 1.5% of variation (5.0% of inherited variance) of role limitation due to emotional problems in patient group. The present study suggests that specific genetic polymorphisms are associated with certain domains of HRQOL and provides a new insight on exploring the factors that predict HRQOL in patients with PD.
authors.affiliation: Department of Psychiatry, Inwha Hospital, Pocheon, Korea .
authors.forename: Eunho
authors.identifier: 0000-0001-7393-9826
authors.initials: E
authors.lastname: Kang
authors.affiliation: Seongnam Mental Health Care Center, Seongnam, Korea .
authors.forename: Ah Young
authors.identifier: 0000-0003-4293-244X
authors.initials: AY
authors.lastname: Choe
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Korea .
authors.forename: Borah
authors.identifier: 0000-0001-9992-9669
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Gumi Medical Center, CHA University, Gumi, Korea .
authors.forename: Jun-Yeob
authors.identifier: 0000-0002-7677-0605
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Korea .
authors.forename: Tai Kiu
authors.identifier: 0000-0003-0221-0573
authors.initials: TK
authors.lastname: Choi
authors.affiliation: Department of Psychiatry, the Catholic University of Korea, Seoul, Korea .
authors.forename: Hae-Ran
authors.identifier: 0000-0002-7960-8603
authors.initials: HR
authors.lastname: Na
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Korea .
authors.forename: Sang-Hyuk
authors.identifier: 0000-0001-5985-624X
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D000483:Alleles; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D012044:Regression Analysis; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012737:Sex Factors
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: 5-HTTLPR; COMT Val158Met; Panic Disorder; Quality of Life