title: Preliminary effects of renal denervation with saline irrigated catheter on cardiac systolic function in patients with heart failure: A Prospective, Randomized, Controlled, Pilot Study.
abstract: OBJECTIVE
  To assess efficacy and safety of renal denervation (RDN) for heart failure (HF).
  
  
  BACKGROUND
  RDN has been demonstrated to be an effective method in lowing overactive sympathetic nerve. However, it's feasibility and efficacy for HF is unclear.
  
  
  METHODS
  In this randomized, controlled pilot study, patients with HF were randomly assigned in 1:1 ratio to undergo RDN plus optimal medical therapy (RDN group) or only optimal medical therapy (control group). Before randomization, patients received optimal medical therapy at least half a year. Primary efficacy end point was the change in LVEF over six months; secondary efficacy end points were the change in six-minute walk distance and SF-36 Health Survey scores over six months.
  
  
  RESULTS
  Up to Apr 2015, sixty symptomatic HF patients were successfully enrolled into study. Thirty patients were randomly assigned to RDN group and 30 patients were randomly assigned to control group. All patients completed six months follow up. During follow up, no severe adverse events were observed. Blood pressure was stable in both groups. Patients in RDN group had shown a significant improvement in LVEF (P < 0.001), SMWD (P = 0.043), NYHA class (P < 0.001), NT-proBNP (P < 0.001) and office heart rate (P = 0.008). Compared with control group, RDN patients were associated with significant improvement in all domains of SF-36 but bodily pain (P = 0.74). No significant change in estimate glomerular filtration nor complication of renal artery stenosis were observed.
  
  
  CONCLUSIONS
  Results imply that RDN could be safely applied to treatment of HF and probably improve cardiac systolic function and patients' quality of life. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Weijie
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Ling
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Zengzhang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Huaan
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Peilin
authors.initials: P
authors.lastname: Xiao
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xianbin
authors.initials: X
authors.lastname: Lan
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Shan
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Yin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017115:Catheter Ablation / Q000379:methods*; D057785:Catheters; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000294:innervation*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D012965:Sodium Chloride / Q000008:administration & dosage*; D013562:Sympathectomy / Q000379:methods*; D013599:Systole; D007507:Therapeutic Irrigation / Q000295:instrumentation; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult
chemical_list: D012965:Sodium Chloride
keywords: heart failure; renal denervation