title: Host Factors in Ebola Infection.
abstract: Ebola virus (EBOV) emerged in West Africa in 2014 to devastating effect, and demonstrated that infection can cause a broad range of severe disease manifestations. As the virus itself was genetically similar to other Zaire ebolaviruses, the spectrum of pathology likely resulted from variable responses to infection in a large and genetically diverse population. This review comprehensively summarizes current knowledge of the host response to EBOV infection, including pathways hijacked by the virus to facilitate replication, host processes that contribute directly to pathogenesis, and host-pathogen interactions involved in subverting or antagonizing host antiviral immunity.
authors.affiliation: Department of Microbiology, University of Washington, Seattle, Washington 98109; email: arasmus@uw.edu.
authors.forename: Angela L
authors.initials: AL
authors.lastname: Rasmussen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D046129:Ebola Vaccines / Q000235:genetics / Q000627:therapeutic use; D029043:Ebolavirus / Q000235:genetics* / Q000472:pathogenicity; D019142:Hemorrhagic Fever, Ebola / Q000235:genetics* / Q000517:prevention & control; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D051379:Mice; D012307:Risk Factors; D014779:Virus Replication / Q000235:genetics*
chemical_list: D046129:Ebola Vaccines
keywords: ebolavirus; filovirus; host response; pathogenesis