title: Multiple organ dysfunction syndrome in critically ill children: clinical value of two lists of diagnostic criteria.
abstract: BACKGROUND
  Two sets of diagnostic criteria of paediatric multiple organ dysfunction syndrome (MODS) were published by Proulx in 1996 and by Goldstein in 2005. We hypothesized that this changes the epidemiology of MODS. Thus, we determined the epidemiology of MODS, according to these two sets of diagnostic criteria, we studied the intra- and inter-observer reproducibility of each set of diagnostic criteria, and we compared the association between cases of MODS at paediatric intensive care unit (PICU) entry, as diagnosed by each set of diagnostic criteria, and 90-day all-cause mortality.
  
  
  METHODS
  All consecutive patients admitted to the tertiary care PICU of Sainte-Justine Hospital, from April 21, 2009 to April 20, 2010, were considered eligible for enrolment into this prospective observational cohort study. The exclusion criteria were gestational age < 40 weeks, age < 3 days or > 18 years at PICU entry, pregnancy, admission immediately after delivery. No patients were censored. Daily monitoring using medical chart ended when the patient died or was discharged from PICU. Mortality was monitored up to death, hospital discharge, or 90 days post PICU entry, whatever happened first. Concordance rate and kappa score were calculated to assess reproducibility. The number of MODS identified with Proulx and Goldstein definitions was compared using 2-by-2 contingency tables. Student's t test or Wilcoxon signed-ranked test was used to compare continuous variables with normal or abnormal distribution, respectively. We performed a Kaplan-Meier survival analysis to assess the association between MODS at PICU entry and 90-day mortality.
  
  
  RESULTS
  The occurrence of MODS was monitored daily and prospectively in 842 consecutive patients admitted to the PICU of Sainte-Justine Hospital over 1 year. According to Proulx and Goldstein diagnostic criteria, 180 (21.4 %) and 314 patients (37.3 %) had MODS over PICU stay, respectively. Concordance of MODS diagnosis over PICU stay was 81.3 % (95 % CI 78.6-83.9 %), and kappa score was 0.56 (95 % CI 0.50-0.61). Discordance was mainly attributable to cardiovascular or neurological dysfunction criteria. The proportion of patients with MODS at PICU entry who died within 90 days was higher with MODS diagnosed with Proulx criteria (17.8 vs. 11.5 %, p = 0.038), as well as the likelihood ratio of death (4.84 vs. 2.37). On the other hand, 90-day survival rate of patients without MODS at PICU entry was similar (98.6 vs. 98.9 % (p = 0.73).
  
  
  CONCLUSIONS
  Proulx and Goldstein diagnostic criteria of paediatric MODS are not equivalent. The epidemiology of paediatric MODS varies depending on which set of diagnostic criteria is applied.
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Sainte-Justine Hospital, CHU Sainte-Justine, Room 3431, 3175 Chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
authors.forename: Andréanne
authors.initials: A
authors.lastname: Villeneuve
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Sainte-Justine Hospital, CHU Sainte-Justine, Room 3431, 3175 Chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Joyal
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Sainte-Justine Hospital, CHU Sainte-Justine, Room 3431, 3175 Chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
authors.forename: François
authors.initials: F
authors.lastname: Proulx
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Sainte-Justine Hospital, CHU Sainte-Justine, Room 3431, 3175 Chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
authors.forename: Thierry
authors.initials: T
authors.lastname: Ducruet
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Sainte-Justine Hospital, CHU Sainte-Justine, Room 3431, 3175 Chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
authors.forename: Nicole
authors.initials: N
authors.lastname: Poitras
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Sainte-Justine Hospital, CHU Sainte-Justine, Room 3431, 3175 Chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada. j_lacroix@videotron.ca.
authors.forename: Jacques
authors.initials: J
authors.lastname: Lacroix
keywords: Critical care; Diagnosis; Intensive care; Mortality; Multiple organ failure; Paediatric