title: Intraventricular temperature measured by diffusion-weighted imaging compared with brain parenchymal temperature measured by MRS in vivo.
abstract: We examined and compared the temperatures of the intraventricular cerebrospinal fluid (Tv ) and the brain parenchyma (Tp ) using MRI, with reference to the tympanic membrane temperature (Tt ) in healthy subjects. We estimated Tv and Tp values from data gathered simultaneously by MR diffusion-weighted imaging (DWI) and MRS, respectively, in 35 healthy volunteers (17 males, 18 females; age 25-78 years). We also obtained Tt values just before each MR examination to evaluate the relationships among the three temperatures. There were significant positive correlations between Tv and Tp (R = 0.611, p < 0.001). The correlation was also significant after correction for Tt (R = 0.642, p < 0.001). There was no significant correlation between Tv and Tt or between Tp and Tt in the men or the women. Negative correlations were found between Tv and age and between Tp and age in the males but not females. DWI thermometry seems to reflect the intracranial environment as accurately as MRS thermometry. An age-dependent decline in temperature was evident in our male subjects by both DWI and MRS thermometry, probably due to the decrease in cerebral metabolism with age. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Radiology, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.|Department of Radiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sumida
authors.affiliation: Department of Radiology, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Sato
authors.affiliation: Department of Mental Disorder Research, National Institute of Mental Health, Tokyo, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Ota
authors.affiliation: Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Daichi
authors.initials: D
authors.lastname: Sone
authors.affiliation: Department of Radiology, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Yokoyama
authors.affiliation: Department of Radiology, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Norihide
authors.initials: N
authors.lastname: Maikusa
authors.affiliation: Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Imabayashi
authors.affiliation: Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.affiliation: Department of Radiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kunimatsu
authors.affiliation: Department of Radiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001831:Body Temperature / Q000502:physiology*; D002552:Cerebral Ventricles / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013696:Temperature; D013817:Thermography / Q000379:methods*
keywords: MRS thermometry; cerebrospinal fluid; diffusion-weighted imaging thermometry; temperature