title: Abnormal resting-state functional connectivity of the left caudate nucleus in obsessive-compulsive disorder.
abstract: Altered brain activities in the cortico-striato-thalamocortical (CSTC) circuitry are implicated in the pathophysiology of obsessive-compulsive disorder (OCD). However, whether the underlying changes occur only within this circuitry or in large-scale networks is still not thoroughly understood. This study performed voxel-based functional connectivity analysis on resting-state functional magnetic resonance imaging (fMRI) data from thirty OCD patients and thirty healthy controls to investigate whole-brain intrinsic functional connectivity patterns in OCD. Relative to the healthy controls, OCD patients showed decreased functional connectivity within the CSTC circuitry but increased functional connectivity in other brain regions. Furthermore, decreased left caudate nucleus-thalamus connectivity within the CSTC circuitry was positively correlated with the illness duration of OCD. This study provides additional evidence that CSTC circuitry may play an essential role and alteration of large-scale brain networks may be involved in the pathophysiology of OCD.
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Michal
authors.initials: M
authors.lastname: Juhás
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Greenshaw
authors.affiliation: Department of Clinical Psychology, Qiqihar Mental Health Center, Qiqihar, Heilongjiang Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Cui
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Yongzhuo
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Kang
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang Province, China. Electronic address: gccui@vip.tom.com.
authors.forename: Guangcheng
authors.initials: G
authors.lastname: Cui
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang Province, China. Electronic address: lipingchxyy@163.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D002421:Caudate Nucleus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D012146:Rest; D055815:Young Adult
keywords: Caudate nucleus; Functional connectivity; Functional magnetic resonance imaging; Obsessive-compulsive disorder; Resting-state