title: Particles with Tunable Porosity and Morphology by Controlling Interfacial Instability in Block Copolymer Emulsions.
abstract: A series of porous block copolymer (BCP) particles with controllable morphology and pore sizes was fabricated by tuning the interfacial behavior of BCP droplets in oil-in-water emulsions. A synergistic adsorption of polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) BCPs and sodium dodecyl sulfate (SDS) to the surface of the emulsion droplet induced a dramatic decrease in the interfacial tension and generated interfacial instability at the particle surface. In particular, the SDS concentration and the P4VP volume fraction of PS-b-P4VP were key parameters in determining the degree of interfacial instability, leading to different types of particles including micelles, capsules, closed-porosity particles, and open-porosity particles with tunable pore sizes ranging from 10 to 500 nm. The particles with open-porosity could be used as pH-responsive, high capacity delivery systems where the uptake and release of multiple dyes could be achieved.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST) , Daejeon 305-701, Republic of Korea.|Materials Research Laboratory, University of California , Santa Barbara, California 93106, United States.
authors.forename: Kang Hee
authors.initials: KH
authors.lastname: Ku
authors.affiliation: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST) , Daejeon 305-701, Republic of Korea.
authors.forename: Jae Man
authors.initials: JM
authors.lastname: Shin
authors.affiliation: Materials Research Laboratory, University of California , Santa Barbara, California 93106, United States.|Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Str. 2-4, Berlin 14195, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Klinger
authors.affiliation: Applied Quantum Composites Research Center, Korea Institute of Science and Technology (KIST) , Jeonbuk, 565-905, Republic of Korea.
authors.forename: Se Gyu
authors.initials: SG
authors.lastname: Jang
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Hayward
authors.affiliation: Materials Research Laboratory, University of California , Santa Barbara, California 93106, United States.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hawker
authors.affiliation: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST) , Daejeon 305-701, Republic of Korea.
authors.forename: Bumjoon J
authors.initials: BJ
authors.lastname: Kim
keywords: block copolymer; drug-delivery; emulsion droplet; interfacial instability; porous particle