title: Intestinal Behçet's disease with pyoderma gangrenosum successfully treated with the combination therapy of adalimumab and glucocorticoids.
abstract: A 24-year-old male presented with orogenital ulcers, folliculitis, and progressive painful skin ulcers with a raised inflammatory border. Colonoscopy revealed volcano-shaped intestinal ulcers in the ascending colon, and hence, he was diagnosed as intestinal Behçets disease (BD) with pyoderma gangrenosum (PG). Treatment with systemic glucocorticoids and adalimumab dramatically improved the patient's symptoms. Our case demonstrates that early induction of adalimumab may contribute to the successful treatment of such difficult-to-treat conditions as intestinal BD with PG.
authors.affiliation: a Department of Rheumatology , Aso Iizuka Hospital , Fukuoka , Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kashiwado
authors.affiliation: a Department of Rheumatology , Aso Iizuka Hospital , Fukuoka , Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Uchino
authors.affiliation: a Department of Rheumatology , Aso Iizuka Hospital , Fukuoka , Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ota
authors.affiliation: a Department of Rheumatology , Aso Iizuka Hospital , Fukuoka , Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Nagano
mesh_terms: D000068879:Adalimumab / Q000008:administration & dosage / Q000627:therapeutic use*; D001528:Behcet Syndrome / Q000150:complications / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D000068879:Adalimumab
keywords: Adalimumab; Intestinal Behçets disease; Pyoderma gangrenosum