title: A meta-analytical assessment of STK39 three well-defined polymorphisms in susceptibility to hypertension.
abstract: Serine/threonine kinase 39 gene (STK39) is one of the promising hypertension-susceptibility genes identified by a genome-wide association study in 2009, whereas subsequent validation in other ethnic groups is unsatisfactory, with inconsistent and inconclusive findings. We therefore aimed to meta-analytically assess the risk prediction of STK39 three polymorphisms, rs6749447, rs35929607 and rs3754777, for primary hypertension. Literature search and data collection were independently completed by two authors. Nine articles were pooled in this study. Overall analyses failed to see any significant associations of rs6749447, rs35929607 and rs3754777 with hypertension risk (odds ratio: 1.27, 0.95 and 1.21; P = 0.270, 0.507 and 0.153, respectively), and there was evident heterogeneity for three comparisons (I(2) > 80%). Meta-regression analyses indicated that smoking was a significant risk factor for the association of rs3754777 with hypertension (P = 0.017). As reflected by the Begg's and Filled funnel plots, as well as Egger's tests, there were low probabilities of publication bias. In conclusion, our meta-analytical findings suggest that STK39 might not be a hypertension-susceptibility gene.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Hualing
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Lingyang
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Dongmiao
authors.initials: D
authors.lastname: Cai
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Qumin
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Basic Medical Science College, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Hongming
authors.initials: H
authors.lastname: Pan
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Zhanxiang
authors.initials: Z
authors.lastname: Wang
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: D017346:Protein Serine-Threonine Kinases; C486409:STK39 protein, human