title: The effect of clomiphene citrate vs. letrozole on post-coital tests.
abstract: OBJECTIVE
  To determine if letrozole is less likely to create a hostile cervical mucus than clomiphene citrate.
  
  
  METHODS
  Post-coital testing compared at time of peak follicular maturation in women attaining mature follicles in first or second cycle of these two drugs. The study was randomized. Intercourse occurred at least 8-16 hours before.
  
  
  RESULTS
  Poor post-coital tests were found in twice the frequency in letrozole cycles than clomiphene citrate cycles.
  
  
  CONCLUSIONS
  Despite its shorter half-life, letrozole seems to be as least as likely, if not more, to adversely affect cervical mucus.
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: J R
authors.initials: JR
authors.lastname: Liss
authors.forename: J
authors.initials: J
authors.lastname: Vaniver
mesh_terms: D000328:Adult; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D002582:Cervix Mucus; D002996:Clomiphene / Q000627:therapeutic use*; D003075:Coitus; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D000077289:Letrozole; D009570:Nitriles / Q000627:therapeutic use*; D006080:Ovarian Follicle; D010062:Ovulation Induction / Q000379:methods; D010865:Pilot Projects; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D005300:Fertility Agents, Female; D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole