title: Zika virus: An update on epidemiology, pathology, molecular biology, and animal model.
abstract: Zika virus (ZIKV) was first described in 1947, and became a health emergency problem in 2016 when its association with fetal microcephaly cases was confirmed by Centers for Disease Control and Prevention (CDC) in the United States. To date, ZIKV infection has been documented in 66 countries. ZIKV is recognized as a neurotropic virus and numerous diseases manifested in multiple neurological disorders have been described, mainly in countries that have been exposed to ZIKV after the 2007 outbreak in the Federated States of Micronesia. The most dramatic consequence of ZIKV infection documented is the abrupt increase in fetal microcephaly cases in Brazil. Here, we present an update of the published research progress in the past few months. J. Med. Virol. 88:1291-1296, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Suzane
authors.initials: S
authors.lastname: Ramos da Silva
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Shou-Jiang
authors.initials: SJ
authors.lastname: Gao
mesh_terms: D000330:Aedes / Q000821:virology; D000818:Animals; D001938:Brazil / Q000453:epidemiology; D004195:Disease Models, Animal; D004196:Disease Outbreaks; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D051379:Mice; D008831:Microcephaly / Q000821:virology; D008849:Micronesia / Q000453:epidemiology; D009422:Nervous System Diseases / Q000821:virology; D011323:Primates; D000071244:Zika Virus / Q000235:genetics*; D000071243:Zika Virus Infection / Q000453:epidemiology* / Q000503:physiopathology* / Q000821:virology
keywords: Zika virus; animal model; epidemiology; pathology; transmission