title: Ambulatory (24 h) blood pressure and arterial stiffness measurement in Marfan syndrome patients: a case control feasibility and pilot study.
abstract: BACKGROUND
  The aim of this work is the investigation of measures of ambulatory brachial and aortic blood pressure and indices of arterial stiffness and aortic wave reflection in Marfan patients.
  
  
  METHODS
  A case-control study was conducted including patients with diagnosed Marfan syndrome following Ghent2 nosology and healthy controls matched for sex, age and daytime brachial systolic blood pressure. For each subject a 24 h ambulatory blood pressure and 24 h pulse wave analysis measurement was performed.
  
  
  RESULTS
  All parameters showed a circadian pattern whereby pressure dipping was more pronounced in Marfan patients. During daytime only Marfan patients with aortic root surgery showed increased pulse wave velocity. In contrast, various nighttime measurements, wave reflection determinants and circadian patterns showed a significant difference.
  
  
  CONCLUSIONS
  The findings of our study provide evidence that ambulatory measurement of arterial stiffness parameters is feasible and that these determinants are significantly different in Marfan syndrome patients compared to controls in particular at nighttime. Further investigation is therefore indicated.
authors.affiliation: Universitäres Herzzentrum Hamburg, Universitätskrankenhaus Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hillebrand
authors.affiliation: Universitäres Herzzentrum Hamburg, Universitätskrankenhaus Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Nouri
authors.affiliation: AIT Austrian Institute of Technology, Donau-City Str. 1, 1220, Vienna, Austria.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hametner
authors.affiliation: AIT Austrian Institute of Technology, Donau-City Str. 1, 1220, Vienna, Austria.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Parragh
authors.affiliation: Universitätsklinikum Schleswig-Holstein, Medizinische Klinik II, Ratzeburger Allee 160, 23538, Lübeck, Germany.
authors.forename: Jelena
authors.initials: J
authors.lastname: Köster
authors.affiliation: Universitätsklinikum Schleswig-Holstein, Medizinische Klinik II, Ratzeburger Allee 160, 23538, Lübeck, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Mortensen
authors.affiliation: IEM GmbH, Cockerillstr. 69, 52222, Stolberg, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Schwarz
authors.affiliation: Universitäres Herzzentrum Hamburg, Universitätskrankenhaus Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
authors.forename: Yskert
authors.initials: Y
authors.lastname: von Kodolitsch
authors.affiliation: AIT Austrian Institute of Technology, Donau-City Str. 1, 1220, Vienna, Austria. Siegfried.Wassertheurer@ait.ac.at.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Wassertheurer
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002940:Circadian Rhythm; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D013997:Time Factors; D059289:Vascular Stiffness