title: Contribution of various lipid profile parameters in determining creatine kinase-MB levels in unstable angina patients.
abstract: BACKGROUND
  In India, the correlation of severity of minor myocardial damage with dyslipidemia has rarely been studied in patients of unstable angina (UA). Dyslipidemia is proven to be a major risk factor for developing acute coronary syndrome (ACS) but still there is doubt about the type of lipoproteins involved in causing minor myocardial damage occurring in UA patients of ACS.
  
  
  OBJECTIVE
  The aim of our study was to find out the contribution of various types of lipoproteins to predict the severity of minor myocardial damage occurring in the patients of UA.
  
  
  METHODS
  Correlation design was used for the study. A single group of individuals was selected. Data were collected on dependent variable creatine kinase-MB (CK-MB) and independent variables (lipid profile parameters).
  
  
  METHODS
  The study comprised fifty patients admitted in cardiac care unit with typical history of UA with electrocardiogram showing no ST-segment elevation. The severity of myocardial damage was assessed from on admission CK-MB levels. The lipid profile was estimated from fasting blood samples of all the patients.
  
  
  METHODS
  For the purpose of the study, Pearson correlation and multiple linear regression analysis methods were applied.
  
  
  RESULTS
  The triacylglycerol (TAG), very-low-density lipoprotein (VLDL), total cholesterol/high-density lipoprotein (TC/HDL) showed significant positive correlation whereas HDL was negatively correlating with CK-MB levels.
  
  
  CONCLUSIONS
  The TAG, VLDL, and TC/HDL were found to be significantly affecting the severity of myocardial damage in the patients of UA.
authors.affiliation: Department of Biochemistry, Pt. J. N. M. Medical College, Raipur, Chhattisgarh, India.
authors.forename: Kiran R
authors.initials: KR
authors.lastname: Bagale
authors.affiliation: Department of Physiology, AIIMS, Raipur, Chhattisgarh, India.
authors.forename: Avinash S
authors.initials: AS
authors.lastname: Ingle
authors.affiliation: School of Studies in Physical Education, Pt. R. S. University, Raipur, Chhattisgarh, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Choudhary
keywords: Acute coronary syndrome; creatine kinase-MB; dyslipidemia; unstable angina