title: Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense.
abstract: This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suganuma
authors.affiliation: Division of Applied Bioscience Research, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan.
authors.forename: Albertus Eka Yudistira
authors.initials: AE
authors.lastname: Sarwono
authors.affiliation: Division of Applied Bioscience Research, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Mitsuhashi
authors.affiliation: Institute of Bioinformatics, Faculty of Medicine, University of Münster, Münster, Germany.
authors.forename: Marcin
authors.initials: M
authors.lastname: Jąkalski
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okada
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan.
authors.forename: Molefe
authors.initials: M
authors.lastname: Nthatisi
authors.affiliation: Division of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Yamagishi
authors.affiliation: Division of Applied Bioscience Research, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ubukata
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan ircpmi@obihiro.ac.jp.
authors.forename: Noboru
authors.initials: N
authors.lastname: Inoue
mesh_terms: D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D009173:Mycophenolic Acid / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014348:Trypanosoma congolense / Q000187:drug effects*
chemical_list: D014344:Trypanocidal Agents; D007168:IMP Dehydrogenase; D009173:Mycophenolic Acid