title: Murine Model for Colitis-Associated Cancer of the Colon.
abstract: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.
authors.affiliation: Northport VA Medical Center, Northport, NY, 11768, USA.|Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.|Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Snider
authors.affiliation: Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Agnieszka B
authors.initials: AB
authors.lastname: Bialkowska
authors.affiliation: Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Amr M
authors.initials: AM
authors.lastname: Ghaleb
authors.affiliation: Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.|Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Vincent W
authors.initials: VW
authors.lastname: Yang
authors.affiliation: Northport VA Medical Center, Northport, NY, 11768, USA.|Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.|Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Lina M
authors.initials: LM
authors.lastname: Obeid
authors.affiliation: Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.|Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Yusuf A
authors.initials: YA
authors.lastname: Hannun
mesh_terms: D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D003092:Colitis / Q000139:chemically induced* / Q000150:complications; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice
chemical_list: D016264:Dextran Sulfate; D001397:Azoxymethane
keywords: AOM/DSS model; Azoxymethane; Colitis-associated cancer; Dextran sulfate sodium; Inflammatory bowel disease; Murine model