title: Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer.
abstract: Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression.
authors.affiliation: Centre for Genomic Regulation, The Barcelona Institute of Science and TechnologyBarcelona, Spain; Universitat Pompeu FabraBarcelona, Spain.
authors.forename: Ester
authors.initials: E
authors.lastname: Saus
authors.affiliation: Department of Oncology Research, Parc Taulí Foundation, Corporació Sanitària Parc Taulí - University Institute - UAB Barcelona Sabadell, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Brunet-Vega
authors.affiliation: Centre for Genomic Regulation, The Barcelona Institute of Science and TechnologyBarcelona, Spain; Universitat Pompeu FabraBarcelona, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Iraola-Guzmán
authors.affiliation: Centre for Genomic Regulation, The Barcelona Institute of Science and TechnologyBarcelona, Spain; Universitat Pompeu FabraBarcelona, Spain.
authors.forename: Cinta
authors.initials: C
authors.lastname: Pegueroles
authors.affiliation: Centre for Genomic Regulation, The Barcelona Institute of Science and TechnologyBarcelona, Spain; Universitat Pompeu FabraBarcelona, Spain; Institució Catalana de Recerca i Estudis AvançatsBarcelona, Spain.
authors.forename: Toni
authors.initials: T
authors.lastname: Gabaldón
authors.affiliation: Department of Oncology Research, Parc Taulí Foundation, Corporació Sanitària Parc Taulí - University Institute - UAB BarcelonaSabadell, Spain; Oncology Service, Hospital de Sabadell, Corporació Sanitària Parc Taulí - University Institute - UAB BarcelonaSabadell, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Pericay
keywords: biomarker; colorectal cancer; long non-coding RNA; ncRNA; prognostic marker