title: The association between polyunsaturated fatty acid consumption and the transition to psychosis in ultra-high risk individuals.
abstract: PUFA deficiencies in cellular membranes have been observed in ultra-high risk (HR) individuals and in early schizophrenia. It is uncertain whether dietary PUFA consumption can be associated with the risk of transition to psychosis in HR individuals. The aim of the study was to assess PUFA consumption and confirm whether dietary habits are related to the risk of transition to full-threshold psychosis in HR individuals during a 12-month follow-up. PUFA consumption during the previous year was analyzed in 62 h individuals and 33 healthy controls (HC) at the beginning of the follow-up period using a validated Food-Frequency Questionnaire and the Polish Food Composition Tables. Fifteen HR individuals converted into psychosis (C-HR) during the 12-month follow-up. C-HR individuals reported significantly higher consumption of n-6 fatty acids (linoleic acid, LA and arachidonic acid, AA) in comparison with individuals who did not develop psychosis (NC-HR). The C-HR group reported a significantly higher AA/(EPA+DHA) consumption ratio than the NC-HR group. HC reported significantly higher consumption of most n-3 PUFA and lower consumption of all n-6 PUFA than both groups of HR individuals. The results suggest that dietary patterns of PUFA consumption may play a role in the conversion to psychosis of HR individuals.
authors.affiliation: Department of Affective and Psychotic Disorders Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland. Electronic address: tomasz.pawelczyk@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Pawełczyk
authors.affiliation: Department of Nutrition Hygiene and Epidemiology Medical University of Lodz, Jaracza 63, 90-251 Lodz, Poland. Electronic address: elzbieta.trafalska@umed.lodz.pl.
authors.forename: E
authors.initials: E
authors.lastname: Trafalska
authors.affiliation: Department of Affective and Psychotic Disorders Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland. Electronic address: magdalena.kotlicka-antczak@umed.lodz.pl.
authors.forename: M
authors.initials: M
authors.lastname: Kotlicka-Antczak
authors.affiliation: Department of Affective and Psychotic Disorders Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland. Electronic address: agnieszka.pawelczyk@umed.lodz.pl.
authors.forename: A
authors.initials: A
authors.lastname: Pawełczyk
mesh_terms: D000293:Adolescent; D000328:Adult; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000209:etiology; D012559:Schizophrenia / Q000097:blood / Q000145:classification*; D055815:Young Adult
chemical_list: D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
keywords: At-risk mental state; Diet; Diet survey; Omega-3 fatty acids; Omega-6 fatty acids; Prevention