title: αv integrins: key regulators of tissue fibrosis.
abstract: Chronic tissue injury with fibrosis results in the disruption of tissue architecture, organ dysfunction and eventual organ failure. Therefore, the development of effective anti-fibrotic therapies is urgently required. During fibrogenesis, complex interplay occurs between cellular and extracellular matrix components of the wound healing response. Integrins, a family of transmembrane cell adhesion molecules, play a key role in mediating intercellular and cell-matrix interactions. Thus, integrins provide a major node of communication between the extracellular matrix, inflammatory cells, fibroblasts and parenchymal cells and, as such, are intimately involved in the initiation, maintenance and resolution of tissue fibrosis. Modulation of members of the αv integrin family has exhibited profound effects on fibrosis in multiple organs and disease states. In this review, we discuss the current knowledge of the mechanisms of αv-integrin-mediated regulation of fibrogenesis and show that the therapeutic targeting of specific αv integrins represents a promising avenue to treat patients with a broad range of fibrotic diseases.
authors.affiliation: MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors.forename: Kylie P
authors.initials: KP
authors.lastname: Conroy
authors.affiliation: MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Kitto
authors.affiliation: MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. Neil.Henderson@ed.ac.uk.
authors.forename: Neil C
authors.initials: NC
authors.lastname: Henderson
mesh_terms: D000818:Animals; D005355:Fibrosis; D006801:Humans; D039564:Integrin alphaV / Q000378:metabolism*; D008954:Models, Biological; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D039564:Integrin alphaV; D016212:Transforming Growth Factor beta
keywords: Extracellular matrix; Fibrosis; Integrins; Myofibroblasts; TGFβ