title: Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water.
abstract: An efficient and facile green synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved via a [Formula: see text]-NPs catalyzed four-component reaction in water. The protocol offers an environmentally benign and effective approach to highly functionalized and biologically interesting spiro[indoline-3,4[Formula: see text]-pyrano[2,3-c]pyrazole] derivatives. The synthesized compounds exhibit potent antioxidant and antibacterial activities.
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan, 712-749, Republic of Korea.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Shrestha
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan, 712-749, Republic of Korea.
authors.forename: Kavita
authors.initials: K
authors.lastname: Sharma
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan, 712-749, Republic of Korea. yrlee@yu.ac.kr.
authors.forename: Yong Rok
authors.initials: YR
authors.lastname: Lee
authors.affiliation: Department of Food Science and Technology, Yeungnam University, Gyeongsan, 712-749, Republic of Korea.
authors.forename: Young-Jung
authors.initials: YJ
authors.lastname: Wee
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000975:Antioxidants / Q000138:chemical synthesis; D001419:Bacteria / Q000187:drug effects; D002384:Catalysis; D002563:Cerium / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D005609:Free Radicals / Q000037:antagonists & inhibitors; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D012997:Solvents; D013141:Spiro Compounds / Q000138:chemical synthesis*; D014867:Water
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005609:Free Radicals; D012997:Solvents; D013141:Spiro Compounds; D014867:Water; D002563:Cerium; C030583:ceric oxide
keywords: Antibacterial; Antioxidant; Cerium oxide nanoparticles; MCRs; Spirooxindoles