title: Cross-Cycloaddition of Two Different Isocyanides: Chemoselective Heterodimerization and [3+2]-Cyclization of 1,4-Diazabutatriene.
abstract: A new cross-cycloaddition reaction between a wide range of isocyanides and 2-isocyanochalcones (or analogues) was developed for the expeditious synthesis of pyrrolo[3,4-b]indoles under thermal conditions. On the basis of the experimental results and DFT calculations, a mechanism for this domino reaction is proposed involving chemoselective heterodimerization of two different isocyanides to form 1,4-diazabutatriene intermediates, followed by an intramolecular [3+2]-cycloaddition and 1,3-proton shift.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Men
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China. liuqun@nenu.edu.cn.
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China. zhangjp162@nenu.edu.cn.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China. xuxx677@nenu.edu.cn.|College of Chemistry and Molecular Engineering (SCME), Institute of Advanced Synthesis (IAS), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816, China. xuxx677@nenu.edu.cn.
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
keywords: 1,4-diazabutatriene; cross-cycloaddition; heterodimerization; isocyanides; pyrrolo[3,4-b]indoles