title: Isotretinoin therapy for the treatment of acne in patients with cystic fibrosis: a case series and review of the literature.
abstract: BACKGROUND
  Cystic fibrosis (CF) is the most common severe autosomal recessive disorder in Caucasians. Viscous secretionstypically obstruct the lungs, pancreas, and gastrointestinal tract. As disease management improves, patients will increasingly seek care for conditions such as acne. Isotretinoin therapy for acne in patients with CF is controversial owing to concerns that the medication may exacerbate CF-related hepatic, pulmonary, and ocular complications.
  
  
  OBJECTIVE
  We describe two patients with CF treated with isotretinoin from our clinic and also provide a literature review of 11 similar cases. We describe patient outcomes, common complications, and the risks for severe adverse effects.
  
  
  METHODS
  The clinical courses of two patients with CF who were treated with isotretinoin for moderate-severe acne are presented. Using PubMed, we analyzed previous case reports of patients with CF who were prescribed isotretinoin and review complications associated with systemic retinoids.
  
  
  RESULTS
  Based on a synthesis of the literature and our own experience, it appears that isotretinoin therapy for CF patients with moderate-severe acne may be an appropriate option when clinically indi ated. If dermatologists monitor lab values and adverseeffects carefully, patients with CF can benefit from isotretinoin therapy.
authors.affiliation: University of California, San Diego School of Medicine.
authors.forename: O
authors.initials: O
authors.lastname: Bari
authors.forename: T
authors.initials: T
authors.lastname: Paravar
mesh_terms: D000152:Acne Vulgaris / Q000150:complications / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D003550:Cystic Fibrosis / Q000150:complications*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin