title: Paradoxical roles of cyclin D1 in DNA stability.
abstract: Maintenance of DNA integrity is vital for all of the living organisms. Consequence of DNA damaging ranges from, introducing harmless synonymous mutations, to causing disease-associated mutations, genome instability, and cell death. A cell cycle protein cyclin D1 is an established cancer-driving protein. However, contribution of cyclin D1 to cancer formation and cancer survival is not entirely known. In cancer tissues, overexpression of cyclin D1 is associated with both cancer genome instability, and resistance to DNA-damaging cancer drugs. Emerging evidence indicated that cyclin D1 may play novel direct roles in regulating DNA repair. Here we provide an insight how cyclin D1 expression may contribute to DNA repair and chromosome instability, and how these functions may facilitate cancer formation, and drug resistance.
authors.affiliation: Laboratory for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address: siwanon.jir@mahidol.ac.th.
authors.forename: Siwanon
authors.initials: S
authors.lastname: Jirawatnotai
authors.affiliation: Laboratory for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Gunya
authors.initials: G
authors.lastname: Sittithumcharee
mesh_terms: D000818:Animals; D019938:Cyclin D1 / Q000378:metabolism*; D004247:DNA / Q000235:genetics*; D004260:DNA Repair; D005786:Gene Expression Regulation; D042822:Genomic Instability; D059765:Homologous Recombination; D006801:Humans
chemical_list: D019938:Cyclin D1; D004247:DNA
keywords: BRCA2; Cancer; Cell cycle; Cyclin D1; Homologous recombination; RAD51