title: Pseudotumor cerebri: What We Have Learned from the Idiopathic Intracranial Hypertension Treatment Trial.
abstract: Idiopathic intracranial hypertension, also known as pseudotumor cerebri, is an unexplained increase in intracranial pressure associated with permanent severe visual loss in 25% of cases and debilitating headaches. The condition is often associated with obesity. The Idiopathic Intracranial Hypertension Treatment Trial, a large, randomized, collaborative clinical trial, evaluated the efficacy of acetazolamide with weight loss versus placebo with weight loss in participants. Herein, we describe the major components of the clinical trial and discuss its shortcomings. [Full article available at http://rimed.org/rimedicaljournal-2016-05.asp, free with no login].
authors.affiliation: Medical Student at the Warren Alpert Medical School of Brown University.
authors.forename: Rachel V
authors.initials: RV
authors.lastname: Thakore
authors.affiliation: Medical Student at the University of North Carolina at Chapel Hill.
authors.forename: Meredith A J
authors.initials: MA
authors.lastname: Johnson
authors.affiliation: Professor of Ophthalmology and Neurology at the Neuro-Ophthalmology Unit, Albany Medical Center, Albany, New York.
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Krohel
authors.affiliation: Neuro-Ophthalmologist and Professor of Surgery (Ophthalmology) at the Warren Alpert Medical School of Brown University; Deputy Chief of Ophthalmology, Rhode Island Hospital, Providence, Rhode Island.
authors.forename: Lenworth N
authors.initials: LN
authors.lastname: Johnson
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage* / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D004232:Diuretics / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009656:North America; D009765:Obesity / Q000150:complications*; D011559:Pseudotumor Cerebri / Q000188:drug therapy* / Q000628:therapy; D015431:Weight Loss; D055815:Young Adult
chemical_list: D004232:Diuretics; D000086:Acetazolamide
keywords: IIHTT; Idiopathic Intracranial Hypertension Treatment Trial; papilledema; perimetric mean deviation; pseudotumor cerebri; visual field loss; weight loss