title: Glycoconjugates of Quinolines: Application in Medicinal Chemistry.
abstract: Compounds with the quinoline scaffold are widely investigated and offer a variety of therapeutical properties. A number of quinoline derivatives have been synthesized and among these there are glycoconjugated derivatives. Based on the interest for this family of compounds, we reviewed the different biological activities (molecular probes, antiinfective, antiproliferative, antiaggregant and antioxidant) and the potential applications in medicinal chemistry of quinoline glycoconjugates. This review wants to show an example of the glycoconjugation strategy which arose not only to modify the water solubility of the quinolines but also to influence their activity and targeting properties.
authors.forename: Valentina
authors.initials: V
authors.lastname: Oliveri
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy. gr.vecchio@unict.it.
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D006001:Glycoconjugates / Q000737:chemistry* / Q000494:pharmacology; D015335:Molecular Probes; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D006001:Glycoconjugates; D015335:Molecular Probes; D011804:Quinolines