title: How we treat bleeding associated with direct oral anticoagulants.
abstract: Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the case of bleeding or emergency situations such as trauma, stroke requiring thrombolysis, and urgent surgery. The progressive development of antidotes for these new drugs, which, it is hoped, will become available in the near future, will allow better and safer management of the rapid reversal of their anticoagulant effect.
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marano
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Vaglio
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Pupella
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Giancarlo M
authors.initials: GM
authors.lastname: Liumbruno
authors.affiliation: Department of Transfusion Medicine and Haematology, "Carlo Poma" Hospital, Mantua, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D020521:Stroke / Q000188:drug therapy; D013923:Thromboembolism / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D000931:Antidotes