title: Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity.
abstract: Four new polyketides: nectriacids A-C (1-3) and 12-epicitreoisocoumarinol (4), together with three known compounds: citreoisocoumarinol (5), citreoisocoumarin (6), and macrocarpon C (7) were isolated from the culture of the endophytic fungus Nectria sp. HN001, which was isolated from a fresh branch of the mangrove plant Sonneratia ovata collected from the South China Sea. Their structures were determined by the detailed analysis of NMR and mass spectroscopic data. The absolute configuration of the stereogenic carbons for compound 4 was further assigned by Mosher's ester method. All of the isolated compounds were tested for their α-glucosidase inhibitory activity by UV absorbance at 405 nm, and new compounds 2 and 3 exhibited potent inhibitory activity with IC50 values of 23.5 and 42.3 μM, respectively, which were more potent than positive control (acarbose, IC50, 815.3 μM).
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. cuihui2@mail2.sysu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Cui
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. liuyayue@mail2.sysu.edu.cn.
authors.forename: Yayue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. drugs999@163.com.|Guangdong Food and Drug Vocational College, Guangzhou 510275, China. drugs999@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Nie
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. liuzhaom@mail2.sysu.edu.cn.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. chensh65@mail2.sysu.edu.cn.
authors.forename: Senhua
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. zhangzhr7@mail2.sysu.edu.cn.
authors.forename: Zhengrui
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Life Sciences and Biomedical Center, Sun Yat-Sen University, Guangzhou 510275, China. luyj@mail.sysu.edu.cn.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Life Sciences and Biomedical Center, Sun Yat-Sen University, Guangzhou 510275, China. helei8688@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. huangxishan13@foxmail.com.
authors.forename: Xishan
authors.initials: X
authors.lastname: Huang
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. cesshzhg@mail.sysu.edu.cn.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
mesh_terms: D002681:China; D060026:Endophytes / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D055330:Nectria / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000494:pharmacology*; D043982:Rhizophoraceae / Q000382:microbiology*; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D061065:Polyketides; D000520:alpha-Glucosidases
keywords: Nectria sp.; pentaene diacid derivatives; polyketides; α-glucosidase inhibitor