title: The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined.
abstract: Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.
authors.affiliation: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 FengLin Road, Shanghai, 200032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jin
authors.affiliation: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 FengLin Road, Shanghai, 200032, China.
authors.forename: Wei-Ren
authors.initials: WR
authors.lastname: Liu
authors.affiliation: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 FengLin Road, Shanghai, 200032, China.
authors.forename: Meng-Xin
authors.initials: MX
authors.lastname: Tian
authors.affiliation: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 FengLin Road, Shanghai, 200032, China.|Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 FengLin Road, Shanghai, 200032, China. shi.yinghong@zs-hospital.sh.cn.
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Shi
mesh_terms: D000818:Animals; D006801:Humans; D008246:Lysophospholipids / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D049349:Receptors, Lysosphingolipid / Q000276:immunology* / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000276:immunology* / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine
keywords: Cancer; Immunity; SphKs/S1P/S1PR1