title: Molecular Dynamics and Physical Stability of Amorphous Nimesulide Drug and Its Binary Drug-Polymer Systems.
abstract: In this article we study the effectiveness of three well-known polymers: inulin, Soluplus, and PVP in stabilizing the amorphous form of nimesulide (NMS) drug. The recrystallization tendency of pure drug as well as measured drug-polymer systems were examined at isothermal conditions by broadband dielectric spectroscopy (BDS) and at nonisothermal conditions by differential scanning calorimetry (DSC). Our investigation has shown that the crystallization half-life time of pure NMS at 328 K is equal to 33 min. We found that this time can be prolonged to 40 years after adding 20% w/w PVP to NMS. This polymer proved to be the best NMS stabilizer, while the worst stabilization effect was exhibited by inulin. Additionally, our DSC, BDS, and FTIR studies indicate that for suppression of NMS recrystallization in the NMS-PVP system, the two mechanisms are responsible: the polymeric steric hindrances and the antiplastization effect exerted by the excipient.
authors.affiliation: Institute of Physics, University of Silesia , ul. Uniwersytecka 4, 40-007 Katowice, Poland.|SMCEBI , ul. 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Knapik
authors.affiliation: Institute of Physics, University of Silesia , ul. Uniwersytecka 4, 40-007 Katowice, Poland.|SMCEBI , ul. 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Wojnarowska
authors.affiliation: Institute of Physics, University of Silesia , ul. Uniwersytecka 4, 40-007 Katowice, Poland.|SMCEBI , ul. 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Grzybowska
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences , Trinity College Dublin , College Green, Dublin 2, Ireland.
authors.forename: L
authors.initials: L
authors.lastname: Tajber
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences , Trinity College Dublin , College Green, Dublin 2, Ireland.
authors.forename: H
authors.initials: H
authors.lastname: Mesallati
authors.affiliation: Centre for Pharmaceutical Engineering Science, Bradford School of Pharmacy, Faculty of Life Sciences, University of Bradford , Richmond Road, BD71DP Bradford, W. Yorks., U.K.
authors.forename: K J
authors.initials: KJ
authors.lastname: Paluch
authors.affiliation: Institute of Physics, University of Silesia , ul. Uniwersytecka 4, 40-007 Katowice, Poland.|SMCEBI , ul. 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Paluch
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods; D003460:Crystallization / Q000379:methods; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D006207:Half-Life; D007444:Inulin / Q000737:chemistry; D056004:Molecular Dynamics Simulation; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D005079:Excipients; D011108:Polymers; D011145:Polyvinyls; D011759:Pyrrolidines; D013449:Sulfonamides; C505150:poly(N-vinylpyrrolidine); C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D011092:Polyethylene Glycols; D007444:Inulin; C012655:nimesulide
keywords: PVP; Soluplus; amorphous drug; drug−polymer system; inulin; molecular dynamics; nimesulide; physical stability