title: Renalase gene polymorphism is associated with increased blood pressure in preeclampsia.
abstract: BACKGROUND
  Renalase is a novel enzyme that degrades circulating catecholamines. We aimed to investigate the role of rs2576178 and rs10887800 polymorphisms of the renalase gene in preeclampsia (PE) patients
  
  
  METHODS
  This case-control study consisted of 110 women with PE and 102 normotensive controls. PCR-RFLP method was used for determination of renalase gene polymorphisms.
  
  
  RESULTS
  Allele frequency and genotype distribution of rs10887800 polymorphism were found statistically significantly higher in women with PE (p<0.05). Also G allele and GG genotype of rs10887800 polymorphism were found higher in women with severe PE than that of mild PE (p<0.05). There was no significant difference for rs2576178 polymorphism in terms of allele frequency and genotype distribution (p>0.05). In PE patients, systolic blood pressure (SBP) means according to rs10887800 genotypes were found statistically significantly higher (GG vs AA; p=0.001) and (GG vs GA; p=0.001). Similarly, diastolic blood pressure (DBP) means were found statistically significantly higher in PE patients (GG vs GA: p=0.001); (GG vs AA: p=0.004). For rs2576178 polymorphism, SBP means were found as (GG vs AA; p=0.012, GG vs GA; p>0.05) in PE patients. DBP means were not significant according to rs2576178 genotypes in PE patients (p>0.05).
  
  
  CONCLUSIONS
  The findings of the present study suggest that blood pressure may be increased by GG genotype and G allele of rs10887800 polymorphism and the polymorphism may increase the susceptibility to PE.
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Cumhuriyet University, 58140 Sivas, Turkey; Advanced Technology Research Center (CÜTAM), Cumhuriyet University, 58140 Sivas, Turkey. Electronic address: binnur.koksal@hotmail.com.
authors.forename: Binnur
authors.initials: B
authors.lastname: Bagci
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Karakus
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Bagci
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Enver
authors.initials: E
authors.lastname: Sancakdar
mesh_terms: D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D001794:Blood Pressure / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy
chemical_list: D005819:Genetic Markers; D008995:Monoamine Oxidase; C521557:renalase
keywords: Blood pressure; Polymorphism; Preeclampsia; Renalase