title: Thin endometrium after radiation therapy as an unresolved treatment challenge: a case report.
abstract: Receptive endometrium is essential for successful implantation and ongoing pregnancy. Significant health issues and associated therapies, especially oncologic therapies, have potential to negatively impact future fertility in young women. Irradiation and chemotherapeutic alkylating agents are known to cause ovarian failure in most females; however, less well is characterized the impact of irradiation on uterine development and integrity. With an increasing number of cancer survivors, women are seeking infertility treatment after such therapies. Here, we present a young woman who developed ovarian failure after the treatment of acute myeloid leukemia with bone marrow transplant and preceding irradiation and chemotherapy and who was diagnosed with thin endometrial lining while seeking infertility therapy.
authors.affiliation: a Montefiore Medical Center/Albert Einstein College of Medicine , Bronx , NY , USA.|c RMA NY, Icahn School of Medicine , NY , USA.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Kudesia
authors.affiliation: a Montefiore Medical Center/Albert Einstein College of Medicine , Bronx , NY , USA.|b Long Island IVF , Melville , NY , USA , and.
authors.forename: Satu
authors.initials: S
authors.lastname: Kuokkanen
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000532:radiotherapy*; D018587:Oocyte Donation; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D014591:Uterine Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
keywords: Oncologic treatment; radiation therapy; thin endometrium; uterus