title: Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome.
abstract: OBJECTIVE
  Human studies have shown the beneficial effects of probiotic microorganisms on the parameters of metabolic syndrome (MetS) and other cardiovascular risks, but to our knowledge the effect of Bifidobacterium lactis has not yet been reported. The aim of this study was to evaluate the effect of consumption of milk containing the probiotic B. lactis HN019 on the classical parameters of MetS and other related cardiovascular risk factors.
  
  
  METHODS
  Fifty-one patients with MetS were selected and divided into a control group (n = 25) and a probiotic group (n = 26). The probiotic group consumed fermented milk with probiotics over the course of 45 d. The effects of B. lactis on lipid profile, glucose metabolism, and proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) were assessed in blood samples of the individuals at the baseline and after 45 d.
  
  
  RESULTS
  Daily ingestion of 80 mL fermented milk with 2.72 × 10(10) colony-forming units of B. lactis HN019 showed significant reduction in body mass index (P = 0.017), total cholesterol (P = 0.009), and low-density lipoprotein (P = 0.008) compared with baseline and control group values. Furthermore, a significant decrease in tumor necrosis factor-α (P = 0.033) and interleukin-6 (P = 0.044) proinflammatory cytokines was observed.
  
  
  CONCLUSIONS
  These data showed potential effects of B. lactis HN019 in reducing obesity, blood lipids, and some inflammatory markers, which may reduce cardiovascular risk in patients with MetS.
authors.affiliation: Program of Master in Dairy Science and Technology, University of North Parana-Unopar, Londrina, Parana, Brazil.
authors.forename: Luciana Jesus
authors.initials: LJ
authors.lastname: Bernini
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, University of Londrina, Londrina, Parana, Brazil.
authors.forename: Andrea Name Colado
authors.initials: AN
authors.lastname: Simão
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, University of Londrina, Londrina, Parana, Brazil.
authors.forename: Daniela Frizon
authors.initials: DF
authors.lastname: Alfieri
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, University of Londrina, Londrina, Parana, Brazil.
authors.forename: Marcell Alysson Batisti
authors.initials: MA
authors.lastname: Lozovoy
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, University of Londrina, Londrina, Parana, Brazil.
authors.forename: Naiara Lourenço
authors.initials: NL
authors.lastname: Mari
authors.affiliation: Program of Master in Dairy Science and Technology, University of North Parana-Unopar, Londrina, Parana, Brazil.
authors.forename: Cínthia Hoch Batista
authors.initials: CH
authors.lastname: de Souza
authors.affiliation: Department of Internal Medicine, University of Londrina, Londrina, Parana, Brazil.
authors.forename: Isaías
authors.initials: I
authors.lastname: Dichi
authors.affiliation: Program of Master in Dairy Science and Technology, University of North Parana-Unopar, Londrina, Parana, Brazil. Electronic address: gcnobre@gmail.com.
authors.forename: Giselle Nobre
authors.initials: GN
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D000328:Adult; D001644:Bifidobacterium; D016207:Cytokines / Q000097:blood* / Q000187:drug effects; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000178:diet therapy*; D008875:Middle Aged; D019936:Probiotics / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D016207:Cytokines; D008055:Lipids
keywords: Bifidobacterium lactis; Cardiovascular risk factors; Cytokines; Metabolic syndrome; Probiotic