title: Effects of neurostimulation for advanced Parkinson's disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials.
abstract: Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). We aim to evaluate the efficacy of GPi (globus pallidus internus), STN (subthalamic nucleus)-DBS and medical therapy for PD. We conducted a systematic review and multiple-treatments meta-analysis to investigate the efficacy of neurostimulation and medical therapy for PD patients. Sixteen eligible studies were included in this analysis. We pooled the whole data and found obvious difference between GPi-DBS versus medical therapy and STN-DBS versus medical therapy in terms of UPDRS scores (Unified Parkinson's Disease Rating Scale). Meanwhile, we found GPi-DBS had the similar efficacy on the UPDRS scores when compared with STN-DBS. What is more, quality of life, measured by PDQ-39 (Parkinson's disease Questionnaire) showed greater improvement after GPi-DBS than STN-DBS. Five studies showed STN-DBS was more effective for reduction in medication than GPi-DBS. Overall, either GPi-DBS or STN-DBS was an effective technique to control PD patients' symptoms and improved their functionality and quality of life. Meanwhile, the UPDRS scores measuring parkinsonian symptoms revealed no significant difference between GPi-DBS and STN-DBS. STN-DBS was more effective for reduction in medication than GPi-DBS. Alternatively, GPi-DBS was more effective for improving the PDQ-39 score than STN-DBS.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Cheng-Long
authors.initials: CL
authors.lastname: Xie
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Shao
authors.affiliation: The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Shi-Yi
authors.initials: SY
authors.lastname: Lin
authors.affiliation: The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Wang
mesh_terms: D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D058542:Implantable Neurostimulators; D010300:Parkinson Disease / Q000601:surgery*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D020531:Subthalamic Nucleus / Q000601:surgery*; D016896:Treatment Outcome