title: Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines.
abstract: We present here an unprecedented cobalt-catalyzed enantioselective vinylation of α-ketoesters, isatins, and imines to deliver a range of synthetically useful allylic alcohols and amines in high enantiopurity. This method employs commercially available and easy to handle catalysts and reagents and exhibits a high degree of practicality. The efficiency, selectivity, and operational simplicity of this catalytic system coupled with the substrate generality render this method a valuable tool in organic synthesis.
authors.affiliation: Department of Chemistry, National University of Singapore , 3 Science Drive 3, Republic of Singapore 117543.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Chemistry, National University of Singapore , 3 Science Drive 3, Republic of Singapore 117543.
authors.forename: Rui-Zhi
authors.initials: RZ
authors.lastname: Huang
authors.affiliation: Department of Chemistry, National University of Singapore , 3 Science Drive 3, Republic of Singapore 117543.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000588:Amines / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007097:Imines; D007211:Indoles; D007659:Ketones; D020005:Propanols; D003035:Cobalt; C006463:allyl alcohol