title: Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer.
abstract: Circadian rhythms are core regulators of a variety of mammalian physiologic processes and oscillate in a 24-h pattern. Many peripheral organs possess endogenous rhythmicity that is then modulated by a master clock; the skin is one of these peripheral organs. The dysregulation of rhythms is associated with decreased ability to ameliorate cellular stressors at a local and global level, which then increases the propensity for the development of neoplastic growths. In this article, we review the implications of altered circadian rhythms on DNA repair as well as modified gene expression of core clock proteins with particular focus on skin models. These findings are then correlated with epidemiologic data regarding skin cancer to showcase the effects of circadian disruption on this phenomenon.
authors.affiliation: School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. dxg290@case.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gutierrez
authors.affiliation: Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH 44106, USA. joshua.arbesman@uhhospitals.org.
authors.forename: Joshua
authors.initials: J
authors.lastname: Arbesman
mesh_terms: D056926:CLOCK Proteins / Q000235:genetics / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology*; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair; D015870:Gene Expression; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology; D008550:Melatonin / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D014466:Ultraviolet Rays
chemical_list: D056926:CLOCK Proteins; D008550:Melatonin
keywords: UVR; circadian rhythms; epidemiology; melatonin; skin cancer