title: The effect of methanolic extract of Buchanania lanzan Spreng seeds on hematological indices.
abstract: OBJECTIVE
  The objective of the current study was carried out to investigate the effects of methanolic extract of Buchanania lanzan Spreng seeds on hematological indices.
  
  
  METHODS
  Eighteen male albino Wistar rats were divided into three groups, six in each. Group I animals received distilled water, Group II and III were treated with an oral dose of 1000 mg oil/kg and 2000 mg oil/kg of extract, respectively, for 7 days. At the end of the study, blood was collected and evaluated for packed cell volume (PCV), hemoglobin (Hb) concentration, and red blood cell (RBC) and white blood cell (WBC) counts.
  
  
  RESULTS
  There was a significant dose-dependent increase in the hematological indices such as PCV, Hb, RBC, and WBC count in the treatment group.
  
  
  CONCLUSIONS
  The improvement of PCV, Hb, and RBC values is an indication of the anti-anemic effect which may be due to the stimulation of RBC production in bone marrow. Further, stimulated production of WBC could be as a result of possible stimulus of the immune system. Hence, this study confirms that the extract of B. lanzan could be useful for the treatment of anemia.
authors.affiliation: Department of Pharmacology and Toxicology, B. R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India.
authors.forename: Mandeep Kumar
authors.initials: MK
authors.lastname: Singh
authors.affiliation: Department of Pharmacology and Toxicology, B. R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India.
authors.forename: Bhrigu Kumar
authors.initials: BK
authors.lastname: Das
authors.affiliation: Department of Pharmacology and Toxicology, B. R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Patidar
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D006454:Hemoglobins / Q000032:analysis*; D019684:Magnoliopsida / Q000196:embryology*; D008297:Male; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*
chemical_list: D006454:Hemoglobins; D010936:Plant Extracts; D000432:Methanol
keywords: Buchanania lanzan; hemoglobin concentration; packed cell volume; red blood cell; white blood cell