title: S6K1ing to ResTOR Adipogenesis with Polycomb.
abstract: Signal-directed chromatin recruitment of mammalian Polycomb complexes is a fundamental component of epigenetic regulation. In this issue, Yi et al. (2016) reveal how mTORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic regulatory regions to repress expression of anti-adipogenic developmental regulators.
authors.affiliation: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Aster H
authors.initials: AH
authors.lastname: Juan
authors.affiliation: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sartorev@mail.nih.gov.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Sartorelli
mesh_terms: D050156:Adipogenesis; D000818:Animals; D002843:Chromatin; D029721:Drosophila Proteins / Q000235:genetics; D044127:Epigenesis, Genetic; D063146:Polycomb-Group Proteins / Q000235:genetics; D058570:TOR Serine-Threonine Kinases / Q000235:genetics
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; D063146:Polycomb-Group Proteins; D058570:TOR Serine-Threonine Kinases