title: HERG1 potassium channel expression in potentially malignant disorders of the oral mucosa and prognostic relevance in oral squamous cell carcinoma.
abstract: HERG1 potassium channel plays a critical role in the cell proliferation.
  
  
  
  HERG1 protein expression was analyzed by immunohistochemistry (IHC) in 62 patients with oral leukoplakias and 100 patients with oral squamous cell carcinomas (OSCC). HERG1 mRNA levels were assessed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 22 patients with primary head and neck squamous cell carcinoma (HNSCC).
  
  
  
  Statistically significant associations were found between HERG1 expression and tobacco consumption, disease stage, tumor differentiation, tumor recurrence, and reduced survival. There was no association between HERG1 expression and the risk of progression from oral leukoplakia to OSCC. In addition, a high proportion of tumors (80%) showed increased HERG1 mRNA levels compared to normal mucosa from nononcologic patients.
  
  
  
  Aberrant HERG1 expression increases as oral tumorigenesis progresses from oral hyperplasia to OSCC. Increased HERG1 mRNA levels were also frequently detected in OSCC and other HNSCC subsites. HERG1 expression emerges as a clinically relevant feature during tumor progression and a potential poor prognostic biomarker for OSCC. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Fernández-Valle
authors.affiliation: Department of Otolaryngology, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain.|Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Edificio Consultas Externas, Planta Baja Lab 2 ORL-IUOPA, Oviedo, Asturias, Spain.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Rodrigo
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain.
authors.forename: Tania
authors.initials: T
authors.lastname: Rodríguez-Santamarta
authors.affiliation: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Edificio Consultas Externas, Planta Baja Lab 2 ORL-IUOPA, Oviedo, Asturias, Spain.
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Villaronga
authors.affiliation: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Edificio Consultas Externas, Planta Baja Lab 2 ORL-IUOPA, Oviedo, Asturias, Spain.
authors.forename: Saúl
authors.initials: S
authors.lastname: Álvarez-Teijeiro
authors.affiliation: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Edificio Consultas Externas, Planta Baja Lab 2 ORL-IUOPA, Oviedo, Asturias, Spain.
authors.forename: Juana M
authors.initials: JM
authors.lastname: García-Pedrero
authors.affiliation: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Edificio Consultas Externas, Planta Baja Lab 2 ORL-IUOPA, Oviedo, Asturias, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Suárez-Fernández
authors.affiliation: Department of Biochemistry, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Lequerica-Fernández
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain. jvicente@.uniovi.es.|Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Edificio Consultas Externas, Planta Baja Lab 2 ORL-IUOPA, Oviedo, Asturias, Spain. jvicente@.uniovi.es.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: de Vicente
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D018450:Disease Progression; D051638:Ether-A-Go-Go Potassium Channels / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007972:Leukoplakia, Oral / Q000378:metabolism*; D009061:Mouth Mucosa / Q000166:cytology / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D051638:Ether-A-Go-Go Potassium Channels; C496884:KCNH1 protein, human
keywords: HERG1; dysplasia; immunohistochemistry; oral carcinoma; potassium channel