title: Pulmonary haemodynamics during recovery from maximum incremental cycling exercise.
abstract: Assessment of cardiac function during exercise can be technically demanding, making the recovery period a potentially attractive diagnostic window. However, the validity of this approach for exercise pulmonary haemodynamics has not been validated.The present study, therefore, evaluated directly measured pulmonary haemodynamics during 2-min recovery after maximum invasive cardiopulmonary exercise testing in patients evaluated for unexplained exertional intolerance. Based on peak exercise criteria, patients with exercise pulmonary hypertension (ePH; n=36), exercise pulmonary venous hypertension (ePVH; n=28) and age-matched controls (n=31) were analysed.By 2-min recovery, 83% (n=30) of ePH patients had a mean pulmonary artery pressure (mPAP) <30 mmHg and 96% (n=27) of ePVH patients had a pulmonary arterial wedge pressure (PAWP) <20 mmHg. Sensitivity of pulmonary hypertension-related haemodynamic measurements during recovery for ePH and ePVH diagnosis was ≤25%. In ePVH, pulmonary vascular compliance (PVC) returned to its resting value by 1-min recovery, while in ePH, elevated pulmonary vascular resistance (PVR) and decreased PVC persisted throughout recovery.In conclusion, we observed that mPAP and PAWP decay quickly during recovery in ePH and ePVH, compromising the sensitivity of recovery haemodynamic measurements in diagnosing pulmonary hypertension. ePH and ePVH had different PVR and PVC recovery patterns, suggesting differences in the underlying pulmonary hypertension pathophysiology.
authors.affiliation: Pulmonary and Critical Care Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Heart and Vascular Center, Brigham and Women's Hospital, Boston, MA, USA Division of Respiratory Diseases, Dept of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Rudolf K F
authors.initials: RK
authors.lastname: Oliveira
authors.affiliation: Pulmonary and Critical Care Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Heart and Vascular Center, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Waxman
authors.affiliation: Pulmonary and Critical Care Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Heart and Vascular Center, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Manyoo
authors.initials: M
authors.lastname: Agarwal
authors.affiliation: Pulmonary and Critical Care Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Heart and Vascular Center, Brigham and Women's Hospital, Boston, MA, USA Dept of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
authors.forename: Roza
authors.initials: R
authors.lastname: Badr Eslam
authors.affiliation: Pulmonary and Critical Care Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Heart and Vascular Center, Brigham and Women's Hospital, Boston, MA, USA dsystrom@partners.org.
authors.forename: David M
authors.initials: DM
authors.lastname: Systrom
mesh_terms: D000368:Aged; D004452:Echocardiography; D015444:Exercise; D005080:Exercise Test / Q000379:methods*; D017079:Exercise Tolerance; D005260:Female; D000074743:Hemodynamic Monitoring; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure; D012307:Risk Factors; D013318:Stroke Volume; D014655:Vascular Resistance