title: Use of a Ureido-Substituted Deoxycytidine Module for DNA Assemblies.
abstract: Ureido-substituted cytosine derivatives are promising for constructing self-assembly structures that can be applied to nanotechnology research. However, conventional cytosine modules achieve assembly in organic solvents. In this study, an N-phenylcarbamoyl deoxycytidine nucleoside was incorporated into a C-rich oligonucleotide to achieve self-assembly in aqueous solution. The results show that the capability of the module to form DNA assemblies varied depending on the number of modules incorporated. The deoxycytidine derivative has a potential application in the development of smart materials based on DNA assembly.
authors.affiliation: a Department of Nanobiochemistry , Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University , Kobe , Japan.
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Nakano
authors.affiliation: b Department of Chemistry , Faculty of Science and Engineering, Konan University , Kobe , Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Oka
authors.affiliation: c Molecular Engineering Institute (MEI), Kinki University , Fukuoka , Japan.|d Department of Environmental and Biological Chemistry , Kinki University , Fukuoka , Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fujii
authors.affiliation: a Department of Nanobiochemistry , Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University , Kobe , Japan.|e Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University , Kobe , Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
mesh_terms: D001483:Base Sequence; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D009841:Oligonucleotides; D003841:Deoxycytidine; D014508:Urea
keywords: Deoxycytidine derivative; i-motif DNA; stacking; thermal stability