title: Successful conservative treatment of a cervical ectopic pregnancy at 13 weeks.
abstract: BACKGROUND
  Cervical ectopic pregnancy is a potentially life-threatening condition due to the unexpected occurrence of uncontrollable bleeding from the cervix.
  
  
  METHODS
  A 39-year-old secundigravida was admitted with amenorrhea of 12 weeks and four days due to suspected cervical pregnancy, without bleeding. The ultrasonography revealed a gestational sac at the anterior wall of the isthmic-cervical part with a single viable fetus, with crown-rump length (CRL) of 59 mm and regular heart rate. The serum β-human chorionic gonadotropin (β-hCG) level on admission was 143.416 mIU/l. Two possible therapeutic options were considered, (1) systemic methotrexate treatment and (2) uterine artery embolization with gelatine sponge. The first was rejected due to gestational age, viable fetus, high β-hCG level, and CRL, and the later was rejected by the vascular surgeons due to lack of experience. The curettage was performed. After the evacuation, prostin was administered into cervix accompanied with tamponade. On the next day β-hCG level was 44.342 mIU/l and the following day ultrasonography revealed the oval non-homogenous formation in the cervical cavity (blood clots or residual trophoblastic tissue); β-hCG level was 36.501 mIU/l. The reintervention was performed on the fifth day after the curettage and 200 ml of coagulated blood was aspirated; β-hCG level was 16.432 mlU/l. Since the isthmic-cervical part was slightly dilated (23 mm) seven days after the curettage, systemic methotrexate treatment (100 mg intramuscular) was initiated. Serum β-hCG level on the second and fourth day after methotrexate were 12.553 mIU/l and 8.900 mIU/l, respectively. The second dose of 100 mg of methotrexate was administered intramuscular seven days after the first dose. Three days after, β-hCG level was 2.329 U/l and ultrasound scan revealed normal isthmic-cervical finding.
  
  
  CONCLUSIONS
  The present case report showed efficient fertility sparing conservative treatment, dilatation and curettage, of 13 week cervical pregnancy followed by systemic methotrexate.
authors.forename: S
authors.initials: S
authors.lastname: Kadija
authors.forename: A
authors.initials: A
authors.lastname: Stefanovic
authors.forename: K
authors.initials: K
authors.lastname: Jeremic
authors.forename: M
authors.initials: M
authors.lastname: Radojevic
authors.forename: R
authors.initials: R
authors.lastname: Cerovic-Popovic
authors.forename: M
authors.initials: M
authors.lastname: Srbinovic
authors.forename: I
authors.initials: I
authors.lastname: Likic-Ladjevic
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D002584:Cervix Uteri / Q000000981:diagnostic imaging / Q000601:surgery*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D018568:Crown-Rump Length; D004107:Dilatation and Curettage / Q000379:methods*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000628:therapy*; D014327:Trophoblasts; D014463:Ultrasonography
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D018997:Chorionic Gonadotropin, beta Subunit, Human; D008727:Methotrexate