title: Dendritic-cell-derived osteoclasts: a new game changer in bone-resorption-associated diseases.
abstract: Bone-resorbing cells, osteoclasts (OCs), and antigen-presenting cells, dendritic cells (DCs), share several features. They are derived from a common hematopoietic precursor, exhibit phagocytic activities and their functions are dependent upon receptor activator of nuclear factor κB ligand (RANKL). Upon inflammatory conditions, DCs can transdifferentiate toward functional OCs in the presence of RANKL. It has then been assumed that the increase in proinflammatory cytokines could provide a supportive environment for this transdifferentiation. In this review, we emphasize the molecular mechanisms underlying the potential for DCs to give rise to resorbing OCs in the context of bone-destruction-associated diseases upon inflammatory conditions. Whether these mechanisms reveal new strategies for the discovery of therapeutic targets and drugs is discussed extensively.
authors.affiliation: INSERM, U791, LIOAD, Nantes F-44042, France; Université de Nantes, UMR-S 791, LIOAD, UFR Odontologie, Nantes F-44042, France; ONIRIS, UMR-S 791, LIOAD, Nantes F-44307, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lapérine
authors.affiliation: CNRS, UMR 7370, LP2M, Faculté de médecine, Nice, France; Université Nice Sophia Antipolis, Nice, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Blin-Wakkach
authors.affiliation: INSERM, U791, LIOAD, Nantes F-44042, France; Université de Nantes, UMR-S 791, LIOAD, UFR Odontologie, Nantes F-44042, France; ONIRIS, UMR-S 791, LIOAD, Nantes F-44307, France; CHU Nantes, PHU 4 OTONN, Nantes F-44042, France. Electronic address: jerome.guicheux@inserm.fr.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guicheux
authors.affiliation: INSERM, U791, LIOAD, Nantes F-44042, France; Université de Nantes, UMR-S 791, LIOAD, UFR Odontologie, Nantes F-44042, France; ONIRIS, UMR-S 791, LIOAD, Nantes F-44307, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Beck-Cormier
authors.affiliation: INSERM, U791, LIOAD, Nantes F-44042, France; Université de Nantes, UMR-S 791, LIOAD, UFR Odontologie, Nantes F-44042, France; ONIRIS, UMR-S 791, LIOAD, Nantes F-44307, France; CHU Nantes, PHU 4 OTONN, Nantes F-44042, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lesclous
mesh_terms: D000818:Animals; D001862:Bone Resorption; D003713:Dendritic Cells / Q000166:cytology*; D006801:Humans; D010010:Osteoclasts / Q000502:physiology*; D053245:RANK Ligand / Q000502:physiology
chemical_list: D053245:RANK Ligand