title: Associations between body composition measurements of obesity and radiographic osteoarthritis in older adults: Data from the Dong-gu Study.
abstract: BACKGROUND
  We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathogenesis of radiographic OA.
  
  
  METHODS
  Data were taken from the Dong-gu cohort, a cross-sectional study of 2,367 subjects. Baseline characteristics, waist circumference (WC), waist-to-hip ratio (WHR), fat mass, and fat percentage were collected, along with X-rays of the knees and hands. Total knee and hand radiographic OA scores were summed using a semi-quantitative grading system, and then stratified by gender using a multiple linear regression model.
  
  
  RESULTS
  After adjusting for confounders, weight was the only factor significantly associated with knee radiographic OA, regardless of gender (all p < 0.01). Regarding the hand, fat percentage had the largest effect on radiographic OA in males (p = 0.008), while WHR was the most significant factor in females (p = 0.001). For the knee, fat mass was the most important factor for radiographic OA in males (p = 0.001), while in females, body mass index was the most important factor (p < 0.001). Among the variables, only fat percentage was significantly related to both hand and knee radiographic OA in both genders (all p < 0.01).
  
  
  CONCLUSIONS
  Regardless of gender, weight was significantly associated with knee radiographic OA. Otherwise, fat deposition correlated with hand and knee radiographic OA in both genders, while the distribution of fat tissue was significantly associated with hand and knee radiographic OA only in females.
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.|Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Lihui
authors.initials: L
authors.lastname: Wen
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Ji-Hyoun
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Yi-Rang
authors.initials: YR
authors.lastname: Yim
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Jeong-Won
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Kyung-Eun
authors.initials: KE
authors.lastname: Lee
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Dong-Jin
authors.initials: DJ
authors.lastname: Park
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Tae-Jong
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea.
authors.forename: Yong-Wook
authors.initials: YW
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Republic of Korea.|Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea.
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.affiliation: Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Republic of Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Yong-Woon
authors.initials: YW
authors.lastname: Yun
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Republic of Korea. mhshinx@paran.com.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, Republic of Korea. shinseok@chonnam.ac.kr.|Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea. shinseok@chonnam.ac.kr.
authors.forename: Shin-Seok
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000368:Aged; D001823:Body Composition / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D050823:Hand Joints / Q000000981:diagnostic imaging*; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D011446:Prospective Studies; D011859:Radiography; D056910:Republic of Korea / Q000453:epidemiology; D055105:Waist Circumference / Q000502:physiology
keywords: Obesity; Osteoarthritis; Radiography