title: Serum antibody responses to vaccinal antigens in lean and obese geriatric dogs.
abstract: The immune responses in control dogs [1 to 4 years of age, body condition score (BCS): 4 to 5 out of 9] were compared to those of aging dogs (based on breed and body size) either categorized as lean (BCS: 4 to 5 out of 9) or obese (BCS: 8 to 9 out of 9). Of interest were the serum titers to the following common agents found in vaccines, canine parainfluenza virus (CPIV), canine parvovirus (CPV), canine distemper virus (CDV), canine respiratory coronavirus (CRCoV), and Bordetella bronchiseptica. There were no statistical differences in the antibodies to CPIV, B. bronchispetica, and CRCoV, among the age/weight categories, nor among the age/weight categories and the time, in days, between the date of sample collection and the date of the last recorded vaccination for CPIV, B. bronchiseptica, CPV, and CDV. For CPV, the control dogs had significantly (P < 0.002) higher serum neutralization (SN) titers than the lean geriatric dogs and the obese geriatric dogs. For CDV SN titers, the only statistically significant (P = 0.01) difference was that the control dogs had higher SN titers than the lean geriatric dogs.
authors.affiliation: Departments of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Large Animal Clinical Sciences (Gow), and Small Animal Clinical Sciences (Kong, Musil, Snead), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: John
authors.initials: J
authors.lastname: Ellis
authors.affiliation: Departments of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Large Animal Clinical Sciences (Gow), and Small Animal Clinical Sciences (Kong, Musil, Snead), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Sheryl
authors.initials: S
authors.lastname: Gow
authors.affiliation: Departments of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Large Animal Clinical Sciences (Gow), and Small Animal Clinical Sciences (Kong, Musil, Snead), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Carrie
authors.initials: C
authors.lastname: Rhodes
authors.affiliation: Departments of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Large Animal Clinical Sciences (Gow), and Small Animal Clinical Sciences (Kong, Musil, Snead), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Stacey
authors.initials: S
authors.lastname: Lacoste
authors.affiliation: Departments of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Large Animal Clinical Sciences (Gow), and Small Animal Clinical Sciences (Kong, Musil, Snead), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Lyndsay
authors.initials: L
authors.lastname: Kong
authors.affiliation: Departments of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Large Animal Clinical Sciences (Gow), and Small Animal Clinical Sciences (Kong, Musil, Snead), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Kristyna
authors.initials: K
authors.lastname: Musil
authors.affiliation: Departments of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Large Animal Clinical Sciences (Gow), and Small Animal Clinical Sciences (Kong, Musil, Snead), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Snead
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D004285:Dogs; D000071497:Immunogenicity, Vaccine; D009765:Obesity / Q000276:immunology / Q000662:veterinary*; D013851:Thinness / Q000276:immunology / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014765:Viral Vaccines