title: The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis.
abstract: Objective. To evaluate the efficacy and safety of the total glucosides of peony (TGP) and leflunomide (LEF) for the treatment of rheumatoid arthritis (RA). Methods. Randomized controlled trials (RCTs) on the efficacy and safety of the combination of TGP and LEF versus LEF alone for the treatment of RA were retrieved by searching PubMed, EMBASE, Cochrane Library, the China National Knowledge Infrastructure database, and Wanfang database. Results. Eight RCTs including 643 RA patients were included in the present meta-analysis. The quality of included studies was poor. The levels of ESR (P < 0.0001), CRP (P < 0.0001), and RF (P < 0.0001) in RA patients who received the combination of TGP and LEF were significantly lower than RA patients who received LEF therapy alone. The pooled results suggest that the combination of TGP and LEF caused less abnormal liver function than LEF alone (P = 0.02). No significant difference in the gastrointestinal discomfort was identified between the combination of TGP and LEF and LEF alone groups (P = 0.18). Conclusion. The combination of TGP and LEF in treatment of RA presented the characteristics of notably decreasing the levels of laboratory indexes and higher safety in terms of liver function. However, this conclusion should be further investigated based on a larger sample size.
authors.affiliation: Postdoctoral Workstation of Chinese and Western Integrative Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China; The Futian Affiliated Hospital of Guangdong Medical Institute, Shenzhen, Guangdong, China; The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China; Shenzhen Institute of Geriatrics, Shenzhen, Guangdong, China.
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Orthopedic Surgery, Hunan Provincial Hospital of Traditional Chinese Medicine, Zhuzhou, Hunan, China.
authors.forename: Guochao
authors.initials: G
authors.lastname: He
authors.affiliation: The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China; Shenzhen Institute of Geriatrics, Shenzhen, Guangdong, China.
authors.forename: Meiqun
authors.initials: M
authors.lastname: Cao
authors.affiliation: The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China; Shenzhen Institute of Geriatrics, Shenzhen, Guangdong, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Duan
authors.affiliation: Postdoctoral Workstation of Chinese and Western Integrative Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: Liguo
authors.initials: L
authors.lastname: Chen
authors.affiliation: The Futian Affiliated Hospital of Guangdong Medical Institute, Shenzhen, Guangdong, China; The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China; Shenzhen Institute of Geriatrics, Shenzhen, Guangdong, China.
authors.forename: Zhengzhi
authors.initials: Z
authors.lastname: Wu