title: Nanostructured Lipid Carriers (NLC) as Vehicles for Topical Administration of Sesamol: In Vitro Percutaneous Absorption Study and Evaluation of Antioxidant Activity.
abstract: Sesamol is a natural phenolic compound extracted fromSesamum indicumseed oil. Sesamol is endowed with several beneficial effects, but its use as a topical agent is strongly compromised by unfavorable chemical-physical properties. Therefore, to improve its characteristics, the aim of the present work was the formulation of nanostructured lipid carriers as drug delivery systems for topical administration of sesamol.Two different nanostructured lipid carrier systems have been produced based on the same solid lipid (Compritol® 888 ATO) but in a mixture with two different kinds of oil phase such as Miglyol® 812 (nanostructured lipid carrier-M) and sesame oil (nanostructured lipid carrier-PLUS). Morphology and dimensional distribution of nanostructured lipid carriers have been characterized by differential scanning calorimetry and photon correlation spectroscopy, respectively. The release pattern of sesamol from nanostructured lipid carriers was evaluatedin vitrodetermining drug percutaneous absorption through excised human skin. Furthermore, an oxygen radical absorbance capacity assay was used to determine their antioxidant activity.From the results obtained, the method used to formulate nanostructured lipid carriers led to a homogeneous dispersion of particles in a nanometric range. Sesamol has been encapsulated efficiently in both nanostructured lipid carriers, with higher encapsulation efficiency values (> 90 %) when sesame oil was used as the oil phase (nanostructured lipid carrier-PLUS).In vitroevidences show that nanostructured lipid carrier dispersions were able to control the rate of sesamol diffusion through the skin, with respect to the reference formulations.Furthermore, the oxygen radical absorbance capacity assay pointed out an interesting and prolonged antioxidant activity of sesamol, especially when vehiculated by nanostructured lipid carrier-PLUS.
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Puglia
authors.affiliation: Department of Pharmacy, University of Salerno, Fisciano (SA), Italy.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Lauro
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Offerta
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Crascì
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Micicchè
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Panico
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bonina
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Puglisi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D052117:Benzodioxoles / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids; D015394:Molecular Structure; D049329:Nanostructures; D010316:Particle Size; D014677:Pharmaceutical Vehicles; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D012869:Skin Absorption
chemical_list: D000975:Antioxidants; D052117:Benzodioxoles; D008055:Lipids; D014677:Pharmaceutical Vehicles; D010636:Phenols; C025583:sesamol