title: CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.
abstract: Cerebrospinal fluid (CSF) levels of d-serine were recently reported as a potential new biomarker for Alzheimer's disease (AD), showing a perfect distinction between AD patients and healthy controls. In this study, we aimed to confirm these results and extend these previous findings to dementia with Lewy bodies and frontotemporal dementia. d-Serine levels in CSF of 29 AD patients, 8 dementia with Lewy bodies patients, 14 frontotemporal dementia patients, and 28 nondemented controls were measured using ultra-high-performance liquid chromatography-tandem mass spectrometry. In contrast to previous findings, in our study CSF d-serine levels were only slightly increased in AD patients compared with controls. CSF d-serine in AD did not differ from other dementias and was also not correlated to mini-mental state examination-scores. Owing to the large overlap of d-serine levels, we conclude that CSF d-serine is neither a suitable biomarker for AD nor for cognitive decline.
authors.affiliation: Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Departments of Neurology and Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands.
authors.forename: Elisanne A L M
authors.initials: EA
authors.lastname: Biemans
authors.affiliation: University Medical Center Utrecht, Center for Molecular Medicine, Utrecht, The Netherlands.
authors.forename: Nanda M
authors.initials: NM
authors.lastname: Verhoeven-Duif
authors.affiliation: University Medical Center Utrecht, Center for Molecular Medicine, Utrecht, The Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: Gerrits
authors.affiliation: Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Geriatric Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands.
authors.forename: Jurgen A H R
authors.initials: JA
authors.lastname: Claassen
authors.affiliation: Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Departments of Neurology and Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands.
authors.forename: H Bea
authors.initials: HB
authors.lastname: Kuiperij
authors.affiliation: Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Departments of Neurology and Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands. Electronic address: marcel.verbeek@radboudumc.nl.
authors.forename: Marcel M
authors.initials: MM
authors.lastname: Verbeek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid*; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002851:Chromatography, High Pressure Liquid; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012694:Serine / Q000134:cerebrospinal fluid*; D053719:Tandem Mass Spectrometry
chemical_list: D015415:Biomarkers; D012694:Serine
keywords: Alzheimer's disease; Biological markers; Cerebrospinal fluid; Dementia with Lewy bodies; Frontotemporal dementia; d-serine