title: In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function.
abstract: Docosahexaenoic acid (DHA) is a prominent nutrient of marine lipids. Together with eicosapentaenoic acid, it is recognized as a protective molecule against atherosclerosis and thrombosis through the regulation of blood cell functions, especially platelets. Its high unsaturation index may however make it prone to peroxidation, which is usually considered as deleterious. This short review takes into consideration this possibility related to DHA concentrations both in vitro and in vivo. It is suggested that protective effects of DHA on platelet activation depend on the reduction of oxidative stress, and appear bimodal with the abolishment of such a protection when DHA is used at relatively high concentrations.
authors.affiliation: Lyon University, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Lagarde
authors.affiliation: Lyon University, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Calzada
authors.affiliation: Lyon University, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Guichardant
authors.affiliation: Lyon University, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Véricel