title: Targeted heat shock protein 72 for pulmonary cytoprotection.
abstract: Heat shock protein 72 (HSP72) is perhaps the most important member of the HSP70 family of proteins, given that it is induced in a wide variety of tissues and cells to combat stress, particularly oxidative stress. Here, we review independent observations of the critical role this protein plays as a pulmonary cytoprotectant and discuss the merits of developing HSP72 as a therapeutic for rapid delivery to cells and tissues after a traumatic event. We also discuss the fusion of HSP72 to a cell-penetrating single-chain Fv antibody fragment derived from mAb 3E10, referred to as Fv-HSP70. This fusion construct has been validated in vivo in a cerebral infarction model and is currently in testing as a clinical therapeutic to treat ischemic events and as a fieldable medical countermeasure to treat inhalation of toxicants caused by terrorist actions or industrial accidents.
authors.affiliation: Rubicon Biotechnology, Lake Forest, California.
authors.forename: Missag H
authors.initials: MH
authors.lastname: Parseghian
authors.affiliation: Rubicon Biotechnology, Lake Forest, California.|Seacoast Science, Inc, Carlsbad, California.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Hobson
authors.affiliation: Rubicon Biotechnology, Lake Forest, California.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Richieri
mesh_terms: D000818:Animals; D019610:Cytoprotection; D050884:HSP72 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000378:metabolism*; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D013312:Stress, Physiological
chemical_list: D050884:HSP72 Heat-Shock Proteins
keywords: HSP70; HSP72; apoptosis inhibitor; medical countermeasure; oxidative stress; reperfusion therapy