title: [The interplay of immunotherapy and chemotherapy, a novel approach].
abstract: In the last decade, a growing body of evidence has highlighted the major role of cancer immunosurveillance. The immune system can recognize tumor cells and keep them under check for long period of time, but is impeded by escape mechanisms induced by the tumor itself. Interestingly, the efficacy of chemotherapy has been shown to depend on the immune response, which in turn is potentiated by chemical agents, creating a positive feedback loop leading to long term tumor resistance. In this review, we summarize some mechanisms underlying the synergy between chemo- and immuno-therapy.
authors.affiliation: Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet, 12 6041 Gosselies, Belgique.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Hanoteau
authors.affiliation: Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet, 12 6041 Gosselies, Belgique.
authors.forename: Coralie
authors.initials: C
authors.lastname: Henin
authors.affiliation: Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet, 12 6041 Gosselies, Belgique.
authors.forename: Muriel
authors.initials: M
authors.lastname: Moser
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D004357:Drug Synergism; D006801:Humans; D007157:Immunologic Surveillance / Q000187:drug effects / Q000502:physiology; D007167:Immunotherapy / Q000379:methods; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D019139:Tumor Escape / Q000187:drug effects / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents