title: Dual stimuli-responsive smart beads that allow "on-off" manipulation of cancer cells.
abstract: Temperature- and electric field-responsive polymer-conjugated polystyrene beads, termed smart beads, are designed to isolate cancer cells. In smart beads, the reversible "on-off" antigen-antibody reaction and dielectrophoresis force on an electrode are accomplished to realize "on-off" remote manipulation of smart beads and cancer cells. Both the zeta-potential and the hydrodynamic diameter of the smart beads are sensitive to temperature, allowing "on-off" reversible capture and release of cancer cells. Cancer cell-captured smart beads are then localized on electrodes by applying an electrical signal.
authors.affiliation: Center for International Research on Integrative Biomedical Systems (CIBiS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8505, Japan. mat@iis.u-tokyo.ac.jp.
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Soo Hyeon
authors.initials: SH
authors.lastname: Kim
authors.forename: Teruo
authors.initials: T
authors.lastname: Fujii
authors.forename: Yukiko T
authors.initials: YT
authors.lastname: Matsunaga
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000906:Antibodies / Q000737:chemistry* / Q000276:immunology*; D001769:Blood; D015820:Cadherins / Q000276:immunology; D045744:Cell Line, Tumor / Q000276:immunology; D002469:Cell Separation / Q000379:methods*; D004586:Electrophoresis; D000071858:Epithelial Cell Adhesion Molecule / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008863:Microspheres; D009360:Neoplastic Cells, Circulating / Q000276:immunology; D011137:Polystyrenes / Q000737:chemistry; D011471:Prostatic Neoplasms; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000906:Antibodies; D015820:Cadherins; C499379:EPCAM protein, human; D000071858:Epithelial Cell Adhesion Molecule; D011137:Polystyrenes; C052970:poly-N-isopropylacrylamide