title: Sex steroids in relation to cardiac structure and function in men.
abstract: The prevalence of testosterone substitution as well as of androgen deprivation therapy in men is increasing. This review aims to summarise available knowledge of the effects of sex steroids on cardiac structure and function in men. MEDLINE was searched through PubMed. Original studies, systematic reviews and meta-analyses, and relevant citations were screened. A short-term hormonal intervention study in healthy young men with respect to echocardiographic parameters of structure and function was performed. Preclinical research provides sufficient evidence for the heart as a substrate for sex hormones. In animals, administration of oestradiol appears to have beneficial effects on cardiac structure and function, whereas administration of testosterone to noncastrated animals adversely affects cardiac function. However, the effects of sex steroids on cardiac function and structure appear more heterogeneous in human observational studies while comparative, prospective studies in humans are lacking. It is concluded that although effects of testosterone substitution as well as of androgen deprivation on cardiac structure and function can be expected based on pre-clinical research, there exists an important knowledge gap of the effects of hormonal intervention in men. As such, there is a need to address this question in future prospective intervention trials.
authors.affiliation: Department of Internal Medicine, Ghent University, Ghent, Belgium.
authors.forename: M A J
authors.initials: MA
authors.lastname: De Smet
authors.affiliation: Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Lapauw
authors.affiliation: Department of Cardiology, Ghent University Hospital, Ghent, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: De Backer
mesh_terms: D000328:Adult; D000367:Age Factors; D000728:Androgens / Q000172:deficiency*; D000818:Animals; D047072:Aromatase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D004452:Echocardiography; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D007006:Hypogonadism / Q000503:physiopathology; D000077289:Letrozole; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009570:Nitriles / Q000008:administration & dosage / Q000494:pharmacology; D012737:Sex Factors; D013739:Testosterone / Q000009:adverse effects / Q000627:therapeutic use; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology; D018608:Ultrasonography, Doppler; D016276:Ventricular Function / Q000187:drug effects*
chemical_list: D000728:Androgens; D047072:Aromatase Inhibitors; D004967:Estrogens; D009570:Nitriles; D014230:Triazoles; D013739:Testosterone; D004958:Estradiol; D000077289:Letrozole
keywords: Cardiac function; cardiac structure; men; oestrogen; testosterone