title: A Subset of TNBCs Exhibit 9p24 Amplifications and JAK2 Dependence.
abstract: JAK2 focal amplifications are associated with reduced survival and resistance to chemotherapy.
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002899:Chromosomes, Human, Pair 9; D004195:Disease Models, Animal; D019008:Drug Resistance, Neoplasm; D005260:Female; D005784:Gene Amplification; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D020360:Neoadjuvant Therapy; D015398:Signal Transduction / Q000187:drug effects; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: D053614:Janus Kinase 2