title: Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone.
abstract: Philadelphia chromosome positive (Ph+) mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia having both myeloid and lymphoid features for which no optimal treatment has yet been established. We herein describe two elderly Ph+MPAL patients who achieved molecular remission without any serious adverse events by treatment with dasatinib and prednisolone. Although dasatinib induction therapy combined with prednisolone is known to be a highly effective treatment for Ph+ acute lymphoblastic leukemia, its efficacy for Ph+MPAL has not been shown. The clinical courses of the present cases suggest that combination therapy with dasatinib and prednisolone is a safe and effective therapeutic modality in elderly Ph+MPAL patients.
authors.affiliation: Department of Hematology, Oita Prefectural Hospital, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takata
authors.forename: Taichi
authors.initials: T
authors.lastname: Ikebe
authors.forename: Hitohiro
authors.initials: H
authors.lastname: Sasaki
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ohtsuka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Saburi
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Shirao
mesh_terms: D000208:Acute Disease; D000368:Aged; D000069439:Dasatinib / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D010641:Phenotype; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011239:Prednisolone; D000069439:Dasatinib