title: Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study.
abstract: Background. The aim of the study was to analyse the effect of caffeic acid phenethyl ester (CAPE) on fluoxetine-induced hepatotoxicity in rats. Materials and Methods. Group I served as control. Group II received CAPE intraperitoneally. Group III received fluoxetine per orally. Group IV received fluoxetine and CAPE. The total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and liver enzymes including paraoxonase-1 (PON-1), aspartate transaminase, and alanine transaminase levels were measured. Liver tissues were processed histopathologically for evaluation of liver injury and to validate the serum enzyme levels. Results. An increase in TOS and OSI and a decrease in TAC and PON-1 levels in serum and liver tissues of Group III were observed compared to Groups I and II. After treatment with CAPE, the level of TOS and OSI decreased while TAC and PON-1 increased in serum and liver in Group IV. Histopathological examination of the liver revealed hepatic injury after fluoxetine treatment and reduction of injury with CAPE treatment. Conclusion. Our results suggested that CAPE treatment provided protection against fluoxetine toxicity. Following CAPE treatment with fluoxetine-induced hepatotoxicity, TOS and OSI levels decreased, whereas PON-1 and TAC increased in the serum and liver.
authors.affiliation: Department of Family Physicians, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yılmaz
authors.affiliation: Department of Immunology, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Elbey
authors.affiliation: Department of Physiology, Faculty of Medicine, Zirve University, 27260 Gaziantep, Turkey.
authors.forename: Ümit Can
authors.initials: ÜC
authors.lastname: Yazgan
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dönder
authors.affiliation: Department of Family Physicians, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Necmi
authors.initials: N
authors.lastname: Arslan
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Department of Pathology, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Ulaş
authors.initials: U
authors.lastname: Alabalık
authors.affiliation: Department of Family Physicians, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Hamza
authors.initials: H
authors.lastname: Aslanhan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood; D002109:Caffeic Acids / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000517:prevention & control; D005473:Fluoxetine / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; D005473:Fluoxetine; C572204:Pon1 protein, rat; D043303:Aryldialkylphosphatase; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol