title: Measurement of Oxygen Consumption in Critically Ill Children: Breath-by-Breath Method vs Mass Spectrometry.
abstract: Measurement of oxygen consumption (Vȯ2) is difficult in children but is essential to calculate cardiac index and systemic vascular resistance.
  
  
  
  To compare measurements of Vȯ2 using respiratory mass spec trometry and the breath-by-breath method.
  
  
  
  Vȯ2 was measured simultaneously and continuously for 10 minutes by using respiratory mass spectrometry and the breath-by-breath method in children receiving mechanical ventilation via cuffed endotracheal tubes.
  
  
  
  Sixteen children (7 boys; median [range]: age, 1.5 [0.2-6] years; weight, 11.5 [2.8-23.5] kg; body surface area, 0.55 [0.18-0.98] m(2)) were studied. The correlation between measurements of Vȯ2 by the 2 methods was good (R = 0.924). Mean Vȯ2 measured by mass spectrometry was 63 (95% CI, 47-78) mL/min vs 65 (95% CI, 47-83) mL/min measured by the breath-by-breath method. The mean Vȯ2 difference between the 2 methods was 3 (95% CI, -9 to 5) mL/min and statistically insignificant. Bland-Altman analysis showed that the 95% limits of agreement were between -28 and +23. Cardiac index did not differ significantly when calculated using Vȯ2 measured with one method or the other (mean difference, 0.1; 95% CI, -0.2 to 0.3).
  
  
  
  Measurements of Vȯ2 did not differ between mass spectrometry and the breath-by-breath method. Use of the breath-by-breath method may facilitate calculation of cardiac index and systemic vascular resistance in critically ill children.
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Long
authors.initials: L
authors.lastname: Guo
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Prashant
authors.initials: P
authors.lastname: Bobhate
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Shine
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Shreepal
authors.initials: S
authors.lastname: Jain
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elgendi
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Scott
authors.initials: S
authors.lastname: Pharis
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Ryerson
authors.affiliation: Long Guo, Yong Cui, Prashant Bobhate, Shine Kumar, and Shreepal Jain were pulmonary hypertension service clinical research fellows; Scott Pharis was a pediatric cardiology fellow; Lindsay Ryerson is an assistant professor of pediatrics and a pediatric cardiac intensivist; and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Cui is now a cardiac surgeon, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Pharis is now a staff pediatric cardiologist, Royal University Hospital, Saskatoon, Saskatchewan, Canada. Mohamed Elgendi is a postdoctorate research fellow, Department of Mathematics and Computing Science, University of Alberta, Edmonton, Canada. iadatia@ualberta.ca.
authors.forename: Ian
authors.initials: I
authors.lastname: Adatia
mesh_terms: D002302:Cardiac Output / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D010101:Oxygen Consumption / Q000502:physiology*; D015203:Reproducibility of Results; D012119:Respiration