title: Long noncoding RNA SNHG1 predicts a poor prognosis and promotes hepatocellular carcinoma tumorigenesis.
abstract: Hepatocellular carcinoma (HCC) is the main cause of cancer mortality worldwide. Its poor prognosis is mainly ascribed to high recurrence rate. Identifying novel prognostic biomarkers and therapeutic targets would be vital for HCC management. Long noncoding RNA (lncRNA) is a class of RNA with various roles in tumorigenesis. The aim of this study was to investigate the clinical significance and functions of lncRNA-small nucleolar RNA host gene 1 (SNHG1) in HCC. In this study, we found SNHG1 was upregulated in HCC tissues in comparison with adjacent liver tissues in both publicly available microarray data and our own cohort. High SNHG1 expression was correlated with large tumor size, poor differentiation, and aggressive BCLC stage. Kaplan-Meier survival analysis demonstrated that high SNHG1 expression predicts poor prognosis of HCC patients. Gain-of-function and loss-of function experiments showed that SNHG1 promotes HCC cells proliferation, cell cycle progression, and inhibits HCC cells apoptosis. Further experiments revealed that SNHG1 promotes HCC cells proliferation through inhibiting p53 and p53-target genes expression. Collectively, our results demonstrated the clinical prognostic significance and roles of SNHG1 in HCC, and suggested that SNHG1 may be considered as a prognostic biomarker and therapeutic target for HCC.
authors.affiliation: Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China. Electronic address: wangweiLMU@yeah.net.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Grade 12 Class 8, Liaoning Medical University, Jinzhou, Liaoning, China.
authors.forename: Tianyue
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ding
authors.affiliation: Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
mesh_terms: D017209:Apoptosis / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics* / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology*; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D030541:Databases, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D062085:RNA, Long Noncoding; D016159:Tumor Suppressor Protein p53; C000613724:long non-coding RNA SNHG1, human
keywords: Hepatocellular carcinoma; Long noncoding RNA; Prognosis; Proliferation; p53