title: Type B insulin resistance syndrome with Scleroderma successfully treated with multiple immune suppressants after eradication of Helicobacter pylori infection: a case report.
abstract: BACKGROUND
  Type B insulin resistance is a rare autoimmune disease characterized by the presence of autoantibodies against the insulin receptor. Helicobacter pylori (H pylori) infection may play a causative role in the autoimmune diseases.
  
  
  METHODS
  Here, we present a rare case of a 48-year old female patient, who had type B insulin resistance with systemic scleroderma and was successfully treated with multiple immune suppressants after eradication of Helicobacter pylori infection.
  
  
  CONCLUSIONS
  The present case suggests H pylori infection-related pathological mechanism may contribute to type B insulin resistance syndrome and autoimmune disorders. Treatment toward H pylori may be helpful to relieve syndrome of type B insulin resistance for H pylori positive patients.
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, No. 28th Fu Xing Road, Beijing, 100853, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, No. 28th Fu Xing Road, Beijing, 100853, China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, No. 28th Fu Xing Road, Beijing, 100853, China.
authors.forename: Jing-Tao
authors.initials: JT
authors.lastname: Dou
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, No. 28th Fu Xing Road, Beijing, 100853, China.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, No. 28th Fu Xing Road, Beijing, 100853, China.
authors.forename: Ju-Ming
authors.initials: JM
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, No. 28th Fu Xing Road, Beijing, 100853, China. muyiming@301hospital.com.cn.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Mu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D001786:Blood Glucose; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007333:Insulin Resistance / Q000276:immunology*; D008875:Middle Aged; D011972:Receptor, Insulin / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D007166:Immunosuppressive Agents; D011972:Receptor, Insulin
keywords: Helicobacter pylori infection; Systemic scleroderma; Type B insulin resistance