title: Newborn screening for SCID: lessons learned.
abstract: BACKGROUND
  Newborn screening (NBS) for Severe combined immunodeficiency (SCID)/severe T cell lymphopenia (sTCL) is being increasingly used worldwide.
  
  
  METHODS
  In this manuscript we will discuss the following: 1) The rationale for screening newborns for SCID/sTCL; 2) The scientific basis for the use of the T cell receptor excision circle (TREC) assay in screening newborns for SCID/sTCL; 3) The published outcomes of current NBS programs. Expert commentary: 4) Some of the ethical dilemmas that occur when screening newborns for SCID. Finally, we will discuss the future directions for expanding NBS to include other primary immunodeficiencies.
authors.affiliation: a Department of Pediatrics , Medical College of Wisconsin , Milwaukee , WI , USA.
authors.forename: Becky J
authors.initials: BJ
authors.lastname: Buelow
authors.affiliation: a Department of Pediatrics , Medical College of Wisconsin , Milwaukee , WI , USA.|b Department of Microbiology and Molecular Genetics , Medical College of Wisconsin and the Children's Research Institute, Medical College of Wisconsin , Milwaukee , WI , USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Verbsky
authors.affiliation: a Department of Pediatrics , Medical College of Wisconsin , Milwaukee , WI , USA.|b Department of Microbiology and Molecular Genetics , Medical College of Wisconsin and the Children's Research Institute, Medical College of Wisconsin , Milwaukee , WI , USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Routes
mesh_terms: D005820:Genetic Testing / Q000941:ethics / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening; D015997:Neonatal Screening / Q000941:ethics / Q000379:methods; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology
chemical_list: D011948:Receptors, Antigen, T-Cell
keywords: Newborn screening (NBS); T cell lymphopenia (TCL); T cell receptor excision circle (TREC); review; severe combined immunodeficiency (SCID)