title: P-cadherin-mediated Rho GTPase regulation during collective cell migration.
abstract: This commentary addresses the role of P-cadherin in collective cell migration (CCM), a cooperative and coordinated migration mode, used by cells during normal and pathological migration processes. We discuss how cadherin-mediated cell-cell junctions (CCJs) play a critical role in CCM through their ability to regulate Rho GTPase-dependent pathways and how this leads to the generation and orientation of mechanical forces. We will also highlight the key function of P-cadherin (a poor prognostic marker in several tumors) in promoting collective cell movement in epithelial and mesenchymal cells.
authors.affiliation: a Institute for Research in Immunology and Cancer, Université de Montréal , Montréal , Québec , Canada.
authors.forename: Cédric
authors.initials: C
authors.lastname: Plutoni
authors.affiliation: b IBDM, Aix-Marseille University-CNRS , Marseille , France.
authors.forename: Elsa
authors.initials: E
authors.lastname: Bazellières
authors.affiliation: c CRBM, Montpellier University-CNRS , Montpellier , France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Gauthier-Rouvière
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015820:Cadherins / Q000378:metabolism*; D002465:Cell Movement; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D015820:Cadherins; D020741:rho GTP-Binding Proteins
keywords: Cdc42; P-cadherin; Rac1; collective cell migration; mechanical forces; polarity; β-PIX