title: Phospholipases as GTPase activity accelerating proteins (GAPs) in plants.
abstract: GTPase activity accelerating proteins (GAPs) are key regulators of the G-protein signaling cycle. By facilitating effective hydrolysis of the GTP bound on Gα proteins, GAPs control the timing and amplitude of the signaling cycle and ascertain the availability of the inactive heterotrimer for the next round of activation. Until very recently, the studies of GAPs in plants were focused exclusively on the regulator of G-protein signaling (RGS) protein. We now show that phospholipase Dα1 (PLDα1) is also a bona fide GAP in plants and together with the RGS protein controls the level of active Gα protein.
authors.affiliation: a Donald Danforth Plant Science Center , St. Louis , MO , USA.
authors.forename: Sona
authors.initials: S
authors.lastname: Pandey
mesh_terms: D020690:GTPase-Activating Proteins / Q000378:metabolism*; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D008954:Models, Biological; D010740:Phospholipases / Q000378:metabolism*; D010944:Plants / Q000201:enzymology*; D015398:Signal Transduction
chemical_list: D020690:GTPase-Activating Proteins; D010740:Phospholipases; D020962:Heterotrimeric GTP-Binding Proteins
keywords: GAP activity; PLDα1; RGS proteins; heterotrimeric G-proteins; phospholipases