title: Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.
abstract: Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr.
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Kuleshov
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Jones
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Rouillard
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Nicolas F
authors.initials: NF
authors.lastname: Fernandez
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Qiaonan
authors.initials: Q
authors.lastname: Duan
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Zichen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Koplev
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Sherry L
authors.initials: SL
authors.lastname: Jenkins
authors.affiliation: Fluid Physics and Transport Processes Branch, NASA Glenn Research Center, 21000 Brookpark Rd., Cleveland, OH 44135, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Jagodnik
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Lachmann
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: McDermott
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Caroline D
authors.initials: CD
authors.lastname: Monteiro
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Gundersen
authors.affiliation: Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA avi.maayan@mssm.edu.
authors.forename: Avi
authors.initials: A
authors.lastname: Ma'ayan
mesh_terms: D019985:Benchmarking; D019295:Computational Biology / Q000379:methods* / Q000706:statistics & numerical data; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D015723:Gene Library; D063990:Gene Ontology; D015894:Genome, Human; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D014584:User-Computer Interface