title: How relevant is panallergen sensitization in the development of allergies?
abstract: Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources. Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, tropomyosins. In addition, we explore the role of panallergens in the sensitization process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitization and clinical manifestations. Finally, the issues related to diagnosis and therapy of patients sensitized to panallergens are outlined, and the use of panallergens as predictors for cross-reactive allergy and as biomarkers for disease severity is discussed.
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
authors.forename: Olivia E
authors.initials: OE
authors.lastname: McKenna
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
authors.forename: Claudia
authors.initials: C
authors.lastname: Asam
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg, Austria.|Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of Uberlandia, Uberlandia, Brazil.
authors.forename: Galber R
authors.initials: GR
authors.lastname: Araujo
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
authors.forename: Anargyros
authors.initials: A
authors.lastname: Roulias
authors.affiliation: Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of Uberlandia, Uberlandia, Brazil.|Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA.
authors.forename: Luiz R
authors.initials: LR
authors.lastname: Goulart
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
authors.forename: Fatima
authors.initials: F
authors.lastname: Ferreira
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D052179:Antigens, Plant / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D003429:Cross Reactions; D005502:Food; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D007073:Immunoglobulin E / Q000378:metabolism; D011058:Pollen / Q000276:immunology; D011237:Predictive Value of Tests; D014335:Tropomyosin / Q000276:immunology
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D015415:Biomarkers; D014335:Tropomyosin; D007073:Immunoglobulin E
keywords: IgE cross-reactivity; allergy diagnosis; allergy treatment; non-specific lipid transfer proteins; pathogenesis-related protein family 10; polcalcins; profilins; tropomyosin