title: Relationship between hypothyroidism and the incidence of gestational diabetes: A meta-analysis.
abstract: OBJECTIVE
  Hypothyroidism disorders and gestational diabetes are among the most common endocrinopathies during pregnancy. We conducted a meta-analysis to investigate whether hypothyroidism in pregnancy is associated with gestational diabetes risk.
  
  
  METHODS
  Published literature from PubMed and EMBASE were searched for eligible publications. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a fixed- or random-effects model.
  
  
  RESULTS
  Seven articles described the relationship between hypothyroidism and risk of gestational diabetes. This meta-analysis revealed that overt hypothyroidism was associated with an increased risk of gestational diabetes (OR 1.892, 95% CI 1.679-2.132, p < 0.001). The relative risk of gestational diabetes was also increased in subclinical hypothyroidism, with the OR of 1.558 (95% CI 1.292-1.877, p < 0.001). There was no evidence of significant association between hypothyroxinemia and risk of gestational diabetes (OR 1.394, 95% CI 0.753-2.580, p = 0.291). The OR for all of the hypothyroidism was 1.749 (95% CI 1.586-1.928, p < 0.001), and an association was found.
  
  
  CONCLUSIONS
  Results of this meta-analysis indicate that hypothyroidism may be a risk factor for gestational diabetes.
authors.affiliation: Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Electronic address: gonglili@126.com.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Gong
authors.affiliation: Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Electronic address: hongllh@126.com.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Liu
mesh_terms: D058070:Asymptomatic Diseases / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology*; D016017:Odds Ratio; D011247:Pregnancy; D012307:Risk Factors
keywords: gestational diabetes; hypothyroidism; meta-analysis