title: Image quality and variability for routine diagnostic FDG-PET scans in a Japanese community hospital: current status and possibility of improvement.
abstract: OBJECTIVE
  In Japan, commercially delivered FDG is manufactured in three batches per day at fixed constant activity and distributed in vials. Consequently, the amount of activity administered to the patient varies depending on the timing of injection. We evaluated a method for adjusting the scan time according to the body mass index (BMI) to obtain equivalent image quality for every patient.
  
  
  METHODS
  We examined a total of 301 routine clinical oncology PET scans using commercially delivered FDG. The relation between the injected activity and the noise equivalent count per scan length (NECpatient) was evaluated as a marker of image quality; its association with BMI was also examined.
  
  
  RESULTS
  The injected activity and NECpatient exhibited large variations (230.4 ± 55.8 MBq and 19.9 ± 2.9 Mcounts/m). There was a weak correlation between the injected activity and NECpatient (r ~ 0.3) for thin patients (BMI < 21 kg/m(2)), but no correlation for patients with higher BMIs. However, a significant correlation was found between BMI and NECpatient (p < 0.0001).
  
  
  CONCLUSIONS
  In a community hospital using commercially delivered FDG, it is possible to reduce the variability of the NECpatient and obtain uniform image quality by changing the scan time as a function of patient BMI, even with uncontrollable injected activity.
authors.affiliation: Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya City, Aichi, 461-8673, Japan. k-shimizu@kcho.jp.|Department of Radiological Technology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-Minamimachi, Chuo-Ku, Kobe-City, Hyogo, 650-0047, Japan. k-shimizu@kcho.jp.
authors.forename: Keiji
authors.initials: K
authors.lastname: Shimizu
authors.affiliation: Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya City, Aichi, 461-8673, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Kyoto College of Medical Science, 1-3, Oyama-Higashimachi-Imakita, Sonobe-Cho, Nantan-City, Kyoto, 622-0041, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Radiological Technology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-Minamimachi, Chuo-Ku, Kobe-City, Hyogo, 650-0047, Japan.
authors.forename: Megumu
authors.initials: M
authors.lastname: Hino
authors.affiliation: Institute of Biomedical Research and Innovation, 2-2, Minatojima Minamimachi, Chuo-ku, Hyogo, 650-0047, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Senda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage*; D006764:Hospitals, Community; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012189:Retrospective Studies
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Commercially delivered FDG; Image quality; Oncology; PET/CT