title: Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs.
abstract: Mitochondria are dynamic double-membrane bound organelles which have key roles in a variety of cellular functions such as energy producing, regulation of calcium flux, cellular stress responses including autophagy and apoptosis. A growing body of evidence indicates that mitochondrial dysfunction is the main culprit in a myriad of diseases such as neurodegenerative disease. This fact opens a new therapeutic window based on targeting mitochondrial dysfunction for treatment of these diseases. Recently an abundance of evidence shows the promising role of polyphenolic compounds on mitochondrial structure and function. Curcumin, a well-known polyphenolic compound, is an abundant component of turmeric. The promising roles of curcumin against different diseases are highly publicized. The aim of the present work is to critically review the scientific evidence to provide a clear view of how curcumin improves mitochondrial dynamics regarding mitochondrial biogenesis and mitophagy. We also present curcumin biosynthesis, source, bioavailability and metabolism in order to give an overview of this compound.
authors.affiliation: Department of Chemistry/ICET, Federal University of MatoGrosso (UFMT), Av. Fernando Corrêa da Costa, 2367, CEP 78060-900, Cuiaba, MT, Brazil. Electronic address: mrobioq@yahoo.com.br.
authors.forename: Marcos Roberto
authors.initials: MR
authors.lastname: de Oliveira
authors.affiliation: Instituto Geral de Perícias (IGP, Forensic Institute), Departamento de Perícias Laboratoriais, Forensic Toxicology Division, Postmortem Toxicology Sector, Av. Ipiranga, 1807, CEP 90160093, Porto Alegre, RS, Brazil.
authors.forename: Fernanda Rafaela
authors.initials: FR
authors.lastname: Jardim
authors.affiliation: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
mesh_terms: D000818:Animals; D002460:Cell Line; D003474:Curcumin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D063306:Mitophagy / Q000187:drug effects / Q000502:physiology; D001678:Organelle Biogenesis
chemical_list: D003474:Curcumin
keywords: Curcumin; Mitochondria; Mitochondrial biogenesis; Mitophagy