title: Prevalence of Pseudoexfoliation Syndrome and Associated Factors in South Koreans: The Korean National Health and Nutrition Examination Survey.
abstract: To investigate the prevalence of pseudoexfoliation syndrome (PXS) and factors associated with PXS in South Koreans by analyzing data from the Korean National Health and Nutrition Examination Survey (KNHANES).
  
  
  
  Using the KNHANES database of 2009-2012, 13,223 participants aged 50 years or older were included. Participants underwent standardized interviews and systemic and ocular examinations. Systemic factors analyzed included age, sex, daily length of sun exposure, presence of Raynaud phenomenon or migraine, hypertension, diabetes mellitus, body mass index, serum lipid profile, duration and frequency of smoking, and alcohol consumption. Evaluated ocular factors were refractive error, presence of cataract and glaucoma, intraocular pressure, and peripheral anterior chamber depth. Logistic regression analysis was performed to identify factors associated with the presence of PXS.
  
  
  
  PXS was found in 16 participants (0.12%). When compared with the non-PXS group, eyes with PXS showed a higher prevalence of cataract (p = 0.020). In logistic regression analysis, age (odds ratio, OR, 1.04, 95% confidence interval, CI, 0.99-1.09; p = 0.016) and the presence of cataract (OR 8.17, 95% CI 1.06-62.84; p = 0.044) were associated with the presence of PXS. Sun exposure for ≥5 hours/day was marginally associated with the presence of PXS (OR 2.76, 95% CI 0.96-7.95; p = 0.060).
  
  
  
  The prevalence of PXS per 1000 persons was 1.10 in South Koreans aged ≥50 years. Participants with PXS had a higher prevalence of cataract, were older, and were more likely to be exposed to the sun for ≥5 hours/day than participants without PXS.
authors.affiliation: a Department of Ophthalmology , College of Medicine, University of Ulsan, Asan Medical Center , Seoul , Korea.
authors.forename: Soa
authors.initials: S
authors.lastname: Kim
authors.affiliation: b Department of Ophthalmology , Yeungnam University, College of Medicine , Daegu , Korea.|c Department of Ophthalmology , Daegu Veterans Health Service Medical Center , Daegu , Korea.
authors.forename: Su-Ho
authors.initials: SH
authors.lastname: Lim
authors.affiliation: a Department of Ophthalmology , College of Medicine, University of Ulsan, Asan Medical Center , Seoul , Korea.
authors.forename: Kyung Rim
authors.initials: KR
authors.lastname: Sung
authors.affiliation: d Department of Clinical Epidemiology and Biostatistics , College of Medicine, University of Ulsan, Asan Medical Center , Seoul , Korea.
authors.forename: Sung-Cheol
authors.initials: SC
authors.lastname: Yun
authors.affiliation: e Department of Ophthalmology , Institute of Vision Research, Yonsei University College of Medicine , Seoul , Korea.
authors.forename: Chan Yun
authors.initials: CY
authors.lastname: Kim
authors.affiliation: f Department of Ophthalmology , Seoul National University, College of Medicine, Seoul National University Hospital , Seoul , Korea.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: b Department of Ophthalmology , Yeungnam University, College of Medicine , Daegu , Korea.
authors.forename: Soon Cheol
authors.initials: SC
authors.lastname: Cha
mesh_terms: D017677:Age Distribution; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D017889:Exfoliation Syndrome / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects
keywords: Cataract; South Korean; glaucoma; prevalence; pseudoexfoliation syndrome