title: Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity.
abstract: BACKGROUND
  Obesity is a risk factor of nonalcoholic fatty liver disease. Although the standard therapy for obesity involves physical exercise, well-planned studies of the changes in liver function in response to different exercise intensities in obese subjects are scarce. The aim of the present study was to examine a question of how does exercise mode affect the liver function.
  
  
  METHODS
  44 women with abdominal obesity were randomized into two exercise groups: endurance (group A) and endurance-strength (group B). Women in each group exercised for 60min 3 times/week for a 3-month period. Markers of liver function: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltranspeptidase (GGT), alkaline phosphatase (ALP) activities, and bilirubin levels were quantified.
  
  
  RESULTS
  We found significant differences in ALT (p<0.01) and AST (p<0.05) activities between group A and B after training exercise. Blood ALT and AST tended to decrease in group B, increase in group A. Significant reduction in serum GGT level after exercise in both groups was observed (p<0.001, group A; p<0.01, group B). Neither endurance nor endurance-strength exercise led to changes in serum ALP activity and total or direct bilirubin level. However, endurance-strength training resulted in significant decreases in serum indirect bilirubin (p<0.05). Strong positive correlations between serum indirect bilirubin and body mass (r=0.615; p=0.0085) and BMI (r=0.576; p=0.0154) were found after endurance-strength exercise (group B).
  
  
  CONCLUSIONS
  The mode of exercise does matter: endurance-strength exercise led to a greater improvement, compared to endurance exercise, in the liver function in women with abdominal obesity.
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, University of Medical Sciences, Szamarzewskiego Str. 82/84, 60-569 Poznań, Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Skrypnik
authors.affiliation: Department of Physiology, Biochemistry and Hygiene, University School of Physical Education, Królowej Jadwigi Str. 27/39, 61-871 Poznań, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Ratajczak
authors.affiliation: Department of Physiology, Biochemistry and Hygiene, University School of Physical Education, Królowej Jadwigi Str. 27/39, 61-871 Poznań, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Karolkiewicz
authors.affiliation: Department of Physiology, University of Medical Sciences, Święcickiego Str. 6, 60-781 Poznań, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Mądry
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, University of Medical Sciences, Szamarzewskiego Str. 82/84, 60-569 Poznań, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Pupek-Musialik
authors.affiliation: Department of Physiotherapy, University of Medical Sciences, Dębinki Str. 7, 80-211 Gdańsk, Poland.
authors.forename: Rita
authors.initials: R
authors.lastname: Hansdorfer-Korzon
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Walkowiak
authors.affiliation: Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University, New Jersey Medical School, International Center for Public Health, 225 Warren Street, Room E450D, Newark, NJ 07103-3535, USA; Department of Biochemistry and Biotechnology, University of Life Sciences, Dojazd Str. 11, 60-632 Poznan, Poland; Institute of Bioorganic Chemistry, Noskowskiego Str. 12/14, 61-704 Poznan, Poland. Electronic address: jakubows@njms.rutgers.edu.
authors.forename: Hieronim
authors.initials: H
authors.lastname: Jakubowski
authors.affiliation: Department of Education and Obesity Treatment and Metabolic Disorders, University of Medical Sciences, Szamarzewskiego Str. 82/84, 60-569 Poznań, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bogdański
mesh_terms: D000328:Adult; D000886:Anthropometry; D001663:Bilirubin / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D056128:Obesity, Abdominal / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology*; D055070:Resistance Training
chemical_list: D001663:Bilirubin
keywords: Liver function; Obesity; Physical exercise