title: CYP7A1, BAAT and UGT1A1 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity.
abstract: Evidence indicates that the polymorphisms in genes involved in bile acid metabolism may play an important role in the development of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in tuberculosis (TB) patients treated with anti-tuberculosis drugs.
  
  
  
  To investigate the association between genetic variants of CYP7A1, BAAT and UGT1A1 and the risk of ATDH in a Chinese cohort.
  
  
  
  In this nested case-control study, 89 TB patients with ATDH and 356 matched ATDH-free TB patients constituted cases and controls, respectively. Genetic polymorphisms of CYP7A1, BAAT and UGT1A1 were determined using the TaqMan single-nucleotide polymorphism genotyping assay. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using a conditional logistic regression model.
  
  
  
  Significant differences were found in genotype distributions of rs1457043 in CYP7A1 between patients with and those without ATDH (P = 0.014). Genotype and haplotype analysis showed that patients carrying an AG genotype of rs1457043 and G-C or G-A haplotypes of rs1457043-rs8192870 in CYP7A1 were at a higher risk of ATDH than those with GG genotype and A-C haplotype, with ORs of respectively 2.05 (95%CI 1.18-3.15) and 2.40 (95%CI 1.62-3.57).
  
  
  
  Genetic polymorphisms of CYP7A1 may be associated with susceptibility to ATDH in the Chinese population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
authors.forename: S-W
authors.initials: SW
authors.lastname: Tang
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Clinical Research Division, Peking University Institute of Mental Health, and Key Laboratory for Mental Health, Ministry of Health, Beijing, China.
authors.forename: X-Z
authors.initials: XZ
authors.lastname: Lv
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.
authors.forename: S-S
authors.initials: SS
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.
authors.forename: Z-R
authors.initials: ZR
authors.lastname: Yang
authors.affiliation: Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Xia
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.
authors.forename: D-F
authors.initials: DF
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.
authors.forename: S-Y
authors.initials: SY
authors.lastname: Zhan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D000217:Acyltransferases / Q000235:genetics; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000235:genetics; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D014453:Glucuronosyltransferase / Q000235:genetics; D008137:Longitudinal Studies; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D014376:Tuberculosis / Q000188:drug therapy; D000099148:UGT1A1 Enzyme
chemical_list: D000217:Acyltransferases; D000995:Antitubercular Agents; D002790:Cholesterol 7-alpha-Hydroxylase; D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme; C026953:bile acid-CoA amino acid N-acyltransferase; C553219:CYP7A1 protein, human