title: The immunogenicity of the intradermal injection of seasonal trivalent influenza vaccine containing influenza A(H1N1)pdm09 in COPD patients soon after a pandemic.
abstract: The antibody responses of a reduced-dose intradermal seasonal influenza vaccination have never been studied in COPD patients soon after a pandemic. A total of 149 COPD patients (60 y of age or older) were randomized to receive trivalent influenza vaccine (Sanofi-Pasteur, France) either 9 µg of hemagglutinin (HA) per strain split into 2-site intradermal (ID) injections via the Mantoux technique or one intramuscular (IM) injection of 15 µg of HA per strain. The geometric mean titers, seroconversion factors, seroconversion rates and seroprotection rates for influenza A(H3N2) and B administered through the ID injection (n = 75) were similar to those obtained with the IM injection (n = 74) 4 weeks post-vaccination. The antibody responses for influenza A(H1N1)pdm09 administered through the ID injection were lower than those obtained with the IM injection, but all of these responses met the 3 criteria proposed by the Committee for Proprietary Medicinal Products (CPMP) for annual re-licensure. The seroprotection rates 4 weeks post-vaccination for influenza A(H1N1)pdm09 were 64.0% (95%CI 52.7-74.0%) in the ID group vs. 78.4% (95% CI 67.6-86.3%) in the IM group (p = 0.053). Influenza-related acute respiratory illness (ARI), diagnosed as a 4-fold rise in HI titers with a convalescent titer > 1:40, and/or the RT-PCR between the ID group (5.3%) and the IM group (8.1%) were not significantly different. The reduced-dose intradermal influenza vaccine may expand vaccine coverage in cases of vaccine shortage.
authors.affiliation: a Division of Respiratory Disease and Tuberculosis, Department of Medicine, Siriraj Hospital , Bangkok , Thailand.
authors.forename: Benjamas
authors.initials: B
authors.lastname: Chuaychoo
authors.affiliation: b Department of Microbiology ; Siriraj Hospital , Bangkok , Thailand.
authors.forename: Uraiwan
authors.initials: U
authors.lastname: Kositanont
authors.affiliation: a Division of Respiratory Disease and Tuberculosis, Department of Medicine, Siriraj Hospital , Bangkok , Thailand.
authors.forename: Nuttapol
authors.initials: N
authors.lastname: Rittayamai
authors.affiliation: a Division of Respiratory Disease and Tuberculosis, Department of Medicine, Siriraj Hospital , Bangkok , Thailand.
authors.forename: Parichat
authors.initials: P
authors.lastname: Niyomthong
authors.affiliation: c Department of Veterinary Pathology , KamphaengSaen , Nakhon Pathom , Thailand.
authors.forename: Thaweesak
authors.initials: T
authors.lastname: Songserm
authors.affiliation: a Division of Respiratory Disease and Tuberculosis, Department of Medicine, Siriraj Hospital , Bangkok , Thailand.
authors.forename: Khun Nanta
authors.initials: KN
authors.lastname: Maranetra
authors.affiliation: a Division of Respiratory Disease and Tuberculosis, Department of Medicine, Siriraj Hospital , Bangkok , Thailand.
authors.forename: Kanokwan
authors.initials: K
authors.lastname: Rattanasaengloet
authors.affiliation: a Division of Respiratory Disease and Tuberculosis, Department of Medicine, Siriraj Hospital , Bangkok , Thailand.
authors.forename: Arth
authors.initials: A
authors.lastname: Nana
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D005602:France; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines
keywords: COPD; acute respiratory illness; immunogenicity; influenza A(H1N1)pdm09; influenza vaccine; intradermal