title: Resolvin D1 Alleviates the Lung Ischemia Reperfusion Injury via Complement, Immunoglobulin, TLR4, and Inflammatory Factors in Rats.
abstract: Lung ischemia-reperfusion injury (LIRI) is still an unsolved medical issue, which negatively affects the prognosis of many lung diseases. The aim of this study is to determine the effects of RvD1 on LIRI and the potential mechanisms involved. The results revealed that the levels of complement, immunoglobulin, cytokines, sICAM-1, MPO, MDA, CINC-1, MCP-1, ANXA-1, TLR4, NF-κBp65, apoptosis index, and pulmonary permeability index were increased, whereas the levels of SOD, GSH-PX activity, and oxygenation index were decreased in rats with LIRI. Except for ANXA-1, these responses induced by LIRI were significantly inhibited by RvD1 treatment. In addition, LIRI-induced structure damages of lung tissues were also alleviated by RvD1 as shown by H&E staining and transmission electron microscopy. The results suggest that RvD1 may play an important role in protection of LIRI via inhibition of complement, immunoglobulin, and neutrophil activation; down-regulation of TLR4/NF-κB; and the expression of a variety of inflammatory factors.
authors.affiliation: The Children's Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Wuhan Medical & Healthcare Center for Woman and Children, Wuhan, People's Republic of China.
authors.forename: Ji
authors.initials: J
authors.lastname: Wu
authors.affiliation: The Children's Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Lin
authors.affiliation: The Children's Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Qingwang
authors.initials: Q
authors.lastname: Hua
authors.affiliation: The Children's Department of Respiration Medicine, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Weixi
authors.initials: W
authors.lastname: Zhang
authors.affiliation: The Children's Department of Respiration Medicine, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Leping
authors.initials: L
authors.lastname: Ye
authors.affiliation: The Children's Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Wu
authors.affiliation: The Children's Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Du
authors.affiliation: The Children's Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xia
authors.affiliation: The Children's Department of Cardiovascular Medicine, Children's Heart Center, the Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
authors.forename: Maoping
authors.initials: M
authors.lastname: Chu
authors.affiliation: The Children's Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China. huxingti@126.com.
authors.forename: Xingti
authors.initials: X
authors.lastname: Hu
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000502:physiology*; D015536:Down-Regulation; D007136:Immunoglobulins / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D055370:Lung Injury / Q000473:pathology*; D051381:Rats; D015427:Reperfusion Injury / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism
chemical_list: D007136:Immunoglobulins; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4; C518399:resolvin D1; D004281:Docosahexaenoic Acids; D003165:Complement System Proteins
keywords: complement; immunoglobulin; inflammation; lung ischemia/reperfusion injury; oxidative stress; resolvin