title: Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin.
abstract: This study is aimed at the development of a composite material for wound dressing containing nanosilver nanohydrogels (nSnH) along with Aloe vera and curcumin that promote antimicrobial nature, wound healing and infection control. Nanosliver nanohydrogels were synthesized by nanoemulsion polymerization of methacrylic acid (MAA) followed by subsequent crosslinking and silver reduction under irradiation. Both the polymerization and irradiation time had significant influence on the nanoparticle shape, size and its formation. Polyvinyl alcohol/polyethylene oxide/carboxymethyl cellulose matrix was used as gel system to blend with nSnH, A. vera, curcumin and coat it on the hydrolysed PET fabric to develop antimicrobial dressings. The cumulative release of silver from the dressing was found to be ~42% of the total loading after 48h. The antimicrobial activity of the dressings was studied against both Staphylococcus aureus and Escherichia coli. In vivo wound healing studies were carried out over a period of 16d on full-thickness skin wounds created on Swiss albino mice. Fast healing was observed in Gel/nSnH/Aloe treated wounds with minimum scarring, as compared to other groups. The histological studies showed A. vera based dressings to be the most optimum one. These results suggest that nSnH along with A. vera based dressing material could be promising candidates for wound dressings.
authors.affiliation: Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
authors.forename: Sadiya
authors.initials: S
authors.lastname: Anjum
authors.affiliation: Department of Pathology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok 737102, India.
authors.forename: Amlan
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Pathology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok 737102, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Sharma
authors.affiliation: Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Gautam
authors.affiliation: Department of Biochemistry, North Eastern Hill University, Shillong 793022, Meghalaya, India.
authors.forename: Surya
authors.initials: S
authors.lastname: Bhan
authors.affiliation: Department of Biochemistry, North Eastern Hill University, Shillong 793022, Meghalaya, India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Arti
authors.initials: A
authors.lastname: Kapil
authors.affiliation: Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India. Electronic address: bgupta@textile.iitd.ernet.in.
authors.forename: Bhuvanesh
authors.initials: B
authors.lastname: Gupta
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000254:growth & development*; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000494:pharmacology; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D012834:Silver; D003474:Curcumin
keywords: Aloe vera; Curcumin; Nanosliver nanohydrogel; Polymethacrylic acid; Wound dressing