title: Does Weight Impact Anidulafungin Pharmacokinetics?
abstract: Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population.
authors.affiliation: Department of Pharmacy, Radboud University Medical Center, 864, PO Box 9101 HB, Nijmegen, 6500, The Netherlands.|Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Lempers
authors.affiliation: Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.|Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
authors.forename: Anne
authors.initials: A
authors.lastname: van Rongen
authors.affiliation: Department of Anaesthesiology, Intensive Care and Pain Management, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Eric P
authors.initials: EP
authors.lastname: van Dongen
authors.affiliation: Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Bert
authors.initials: B
authors.lastname: van Ramshorst
authors.affiliation: Department of Pharmacy, Radboud University Medical Center, 864, PO Box 9101 HB, Nijmegen, 6500, The Netherlands.|Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
authors.forename: David M
authors.initials: DM
authors.lastname: Burger
authors.affiliation: Department of Pharmacy, Radboud University Medical Center, 864, PO Box 9101 HB, Nijmegen, 6500, The Netherlands.|Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
authors.forename: Rob E
authors.initials: RE
authors.lastname: Aarnoutse
authors.affiliation: Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.|Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
authors.forename: Catherijne A
authors.initials: CA
authors.lastname: Knibbe
authors.affiliation: Department of Pharmacy, Radboud University Medical Center, 864, PO Box 9101 HB, Nijmegen, 6500, The Netherlands. roger.bruggemann@radboudumc.nl.|Radboud Institute for Health Sciences, Nijmegen, The Netherlands. roger.bruggemann@radboudumc.nl.
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Brüggemann
mesh_terms: D000328:Adult; D000368:Aged; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D015992:Body Mass Index; D054714:Echinocandins / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin