title: A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells.
abstract: A fluorescent probe for fulfilling a lysosome targeting function in hypoxic tumor cells is reported, wherein azoreductase triggers a dramatic fluorescence enhancement and specific imaging of lysosomes in hypoxic cancer cells.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China and Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
authors.forename: Sihang
authors.initials: S
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, Provincial hospital affiliated to Shandong University, Jinan, 250021, China. 13805311573@126.com.
authors.forename: Yingchao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
authors.forename: Feiyi
authors.initials: F
authors.lastname: Wang
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fei
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
authors.forename: Ben
authors.initials: B
authors.lastname: Shi
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
authors.forename: Jiancai
authors.initials: J
authors.lastname: An
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
authors.forename: Chunchang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China.
authors.forename: Chen-Ho
authors.initials: CH
authors.lastname: Tung
mesh_terms: D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008247:Lysosomes / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes