title: Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.
abstract: Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.
authors.affiliation: Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA.
authors.forename: Markus
authors.initials: M
authors.lastname: von Schaewen
authors.affiliation: Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Hrebikova
authors.affiliation: Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA. aploss@princeton.edu.
authors.forename: Alexander
authors.initials: A
authors.lastname: Ploss
mesh_terms: D000818:Animals; D015925:Cryopreservation; D004195:Disease Models, Animal; D022781:Hepatocytes / Q000166:cytology / Q000637:transplantation*; D006801:Humans; D008099:Liver / Q000166:cytology* / Q000254:growth & development; D008115:Liver Regeneration; D051379:Mice; D018183:Transplantation Chimera / Q000254:growth & development*; D014183:Transplantation, Heterologous
keywords: DMPK; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Human liver chimeric mice; Humanized mice; Malaria; Viral hepatitis