title: Terahertz spectroscopy for bacterial detection: opportunities and challenges.
abstract: The demand for advanced bacterial detection tools is continuously increasing, promoted by its significant benefits in various applications. For instance, in the medical field, these tools would facilitate decision making about more tailored therapies once the infection source has been identified. In the past few years, terahertz (THz = 10(12) Hz) spectroscopy has also shown potential as a novel bacterial detection modality due to its unique advantages. Impressive breakthroughs have been achieved in this field related to bacterial component characterization, spore identification, and cell detection. However, some intrinsic limitations and technical bottlenecks have led to some debates about the practicability of its clinical adoption. In this review, we summarize the progress achieved in this field and discuss some challenges and strategies for future implementation of practical applications.
authors.affiliation: Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.affiliation: Medical Research Center, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. luoyang@tmmu.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. weiling_fu@126.com.
authors.forename: Weiling
authors.initials: W
authors.lastname: Fu
mesh_terms: D001419:Bacteria / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000175:diagnosis; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D006801:Humans; D013171:Spores, Bacterial / Q000302:isolation & purification; D055068:Terahertz Spectroscopy / Q000295:instrumentation / Q000379:methods
keywords: Bacterial detection; Biosensor; Rapid detection; Spore; Terahertz time-domain spectroscopy