title: [THE EFFECT OF PERINATAL HYPOXIA ON THE STRUCTURE OF BLOOD-BRAIN BARRIER IN RATS TREATED WITH SALIFEN].
abstract: The work was performed on Wistar rats, which were dividedinto 3 groups: 1st group--experimental rats subjected to hypoxia and treated with salifen (15 mg/kg for 14 days), 2nd group--control rats exposed to hypoxia only without treatment, and 3rdgroup--intact animals (8-10 animals in each group). Using themethods of light and electron microscopy, the effect of salifen onthe structural characteristics of the elements of the blood-brainbarrier (BBB) in the neocortex was studied in rats after exposureto hypoxia in the early postnatal period--on postnatal Day 2(model of human preterm pregnancy). The results showed thatsalifen had a positive effect on the state of the microvasculatureafter perinatal hypoxia, in particular, on the state of endothelialcells. Its active participation in the compensatory-adaptive reactions of the BBB in response to hypoxia exposure was detected,and the prospects of further studies of the protective properties ofsalifen are emphasized.
authors.forename: V A
authors.initials: VA
authors.lastname: Otellin
authors.forename: L I
authors.initials: LI
authors.lastname: Khozhai
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D002196:Capillaries / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000473:pathology; D008854:Microscopy, Electron; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D018696:Neuroprotective Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid