title: Severe anaphylaxis to Propofol: first case of evidence of sensitization to soy oil.
abstract: The growing worldwide prevalence of food allergies is drawing attention to the risk of allergenic proteins found in intravenous medicinal products, particularly anaesthetics. Propofol induced anaphylaxis has been described. The presence of soybean oil and egg lecithins in the lipid emulsion highlights their suspected responsibility in certain cases. We report a case of anaphylaxis to propofol in an adult patient without food allergy to soy, but with a latent sensitization to soy. An IgE-dependent allergy to propofol was established by a basophil activation test. Here, we document for the first time the existence of specific IgEs to a 65kDa protein, found in soybean oil and soy flour. In the absence of data on the reactogenic threshold for allergenic food proteins injected intravenously, a risk appears to be established and leads us to recommend a systematic detection for proteins in the refined soybean oil used in the pharmaceutical industry for intravenous products.
authors.affiliation: Genclis SA, Biotechnology Company, 15 rue du Bois de la Champelle, Vandoeuvre-lès-Nancy, France. E-mail: c.richard@genclis.com.
authors.forename: C
authors.initials: C
authors.lastname: Richard
authors.affiliation: Department of Allergy, Emile Durkheim Hospital, 31 rue Thiers, Epinal, France.
authors.forename: E
authors.initials: E
authors.lastname: Beaudouin
authors.affiliation: Department of Allergy, Emile Durkheim Hospital, 31 rue Thiers, Epinal, France. Faculty of Medicine, Lorraine University, France. Deceased 27 March 2016.
authors.forename: D A
authors.initials: DA
authors.lastname: Moneret-Vautrin
authors.affiliation: Laboratory of Immunology, University Hospital, Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Kohler
authors.affiliation: Department of Allergy, Emile Durkheim Hospital, 31 rue Thiers, Epinal, France.
authors.forename: V M
authors.initials: VM
authors.lastname: Nguyen-Grosjean
authors.affiliation: Genclis SA, Biotechnology Company, 15 rue du Bois de la Champelle, Vandoeuvre-lès-Nancy, France.
authors.forename: S
authors.initials: S
authors.lastname: Jacquenet
mesh_terms: D000485:Allergens; D000707:Anaphylaxis; D005512:Food Hypersensitivity; D006801:Humans; D010938:Plant Oils; D015742:Propofol; D013025:Glycine max
chemical_list: D000485:Allergens; D010938:Plant Oils; D015742:Propofol
keywords: allergenicity; anaphylaxis; propofol; soy oil