title: Sleep Dysfunction and Gastrointestinal Diseases.
abstract: Sleep deprivation and impaired sleep quality have been associated with poor health outcomes. Many patients experience sleep disturbances, which can increase the risk of medical conditions such as hypertension, obesity, stroke, and heart disease as well as increase overall mortality. Recent studies have suggested that there is a strong association between sleep disturbances and gastrointestinal diseases. Proinflammatory cytokines, such as tumor necrosis factor, interleukin-1, and interleukin-6, have been associated with sleep dysfunction. Alterations in these cytokines have been seen in certain gastrointestinal diseases, such as gastroesophageal reflux disease, inflammatory bowel disease, liver disorders, and colorectal cancer. It is important for gastroenterologists to be aware of the relationship between sleep disorders and gastrointestinal illnesses to ensure good care for patients. This article reviews the current research on the interplay between sleep disorders, immune function, and gastrointestinal diseases.
authors.affiliation: Dr Khanijow and Dr Prakash are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Emsellem is a clinical professor of neurology at George Washington University Medical Center and is director of the Center for Sleep and Wake Disorders in Chevy Chase, Maryland. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC and is director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; she is also affiliated with Medical Faculty Associates. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine.
authors.forename: Vikesh
authors.initials: V
authors.lastname: Khanijow
authors.affiliation: Dr Khanijow and Dr Prakash are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Emsellem is a clinical professor of neurology at George Washington University Medical Center and is director of the Center for Sleep and Wake Disorders in Chevy Chase, Maryland. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC and is director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; she is also affiliated with Medical Faculty Associates. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine.
authors.forename: Pia
authors.initials: P
authors.lastname: Prakash
authors.affiliation: Dr Khanijow and Dr Prakash are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Emsellem is a clinical professor of neurology at George Washington University Medical Center and is director of the Center for Sleep and Wake Disorders in Chevy Chase, Maryland. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC and is director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; she is also affiliated with Medical Faculty Associates. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine.
authors.forename: Helene A
authors.initials: HA
authors.lastname: Emsellem
authors.affiliation: Dr Khanijow and Dr Prakash are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Emsellem is a clinical professor of neurology at George Washington University Medical Center and is director of the Center for Sleep and Wake Disorders in Chevy Chase, Maryland. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC and is director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; she is also affiliated with Medical Faculty Associates. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine.
authors.forename: Marie L
authors.initials: ML
authors.lastname: Borum
authors.affiliation: Dr Khanijow and Dr Prakash are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Emsellem is a clinical professor of neurology at George Washington University Medical Center and is director of the Center for Sleep and Wake Disorders in Chevy Chase, Maryland. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC and is director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; she is also affiliated with Medical Faculty Associates. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine.
authors.forename: David B
authors.initials: DB
authors.lastname: Doman
keywords: Sleep; circadian rhythm; cytokine; gastrointestinal disorders; immune system; irritable bowel syndrome