title: Intravoxel incoherent motion diffusion weighted MRI of cervical cancer - Correlated with tumor differentiation and perfusion.
abstract: To investigate the value of parameters derived from IVIM model in grading of uterine cervical cancer and the relationship between perfusion parameters derived from IVIM and that from DCE-MRI.
  
  
  
  Parameters of DWI (ADC, D, f, D*) and semi-quantitative parameters of DCE-MRI (Slop, Maxslop, CER, Washout, AUC90) were assessed in 24 female with cervical cancers. Except for ROIs encompassed all of the area of tumors in axial plane (A_all), ROIs on tumor edge (A_peri) and tumor center (A_central) were drawn. All of the parameters were compared among three pathology grades. Perfusion parameters derived from IVIM were correlated with that from DCE-MRI.
  
  
  
  For G1, G2 and G3 tumors, on tumor edge ADC=(1.03±0.11), (1.05±0.10), (0.90±0.05)×10(-3)mm(2)/s, D=(0.80±0.11), (0.78±0.07), (0.69±0.06)×10(-3)mm(2)/s, and f=(0.19±0.03), (0.22±0.02), (0.24±0.03). The differences among groups were significant (P<0.05). On tumor center, ADC=(0.90±0.10), (0.85±0.03), (0.80±0.07)×10(-3)mm(2)/s with significant differences (P=0.027). The other parameter, D and f of tumor center, as well as D* of all tumor areas, were of no statistic significance. Most of the DCE-MRI parameters negatively correlated with tumor volume. Although the correlation between f and slop was statistic significant, R=0.277 meant a negligible correlation. f had week correlation with Maxslop, CER and AUC90 (R=0.361, 0.400 and 0.405; P<0.001). D* showed no statistic significant correlation with all of the DCE parameters.
  
  
  
  IVIM model could possibly be used to evaluate tumor differentiation and perfusion, providing an alternative for DCE-MRI.
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China. Electronic address: jyliubysy@163.com.
authors.forename: Jianyu
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China; Department of Pathology, Peking University Health Science Center, 38 College Road, Haidian, Beijing 100191, China.
authors.forename: Congrong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pathology, Beijing Shijingshan Hospital, Beijing Shijingshan Road, Shijingshan District, No. 24, Beijing 100043, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
authors.affiliation: Clinical Epidemiology Research Center, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: GE Healthcare China, Beijing, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Xie
authors.affiliation: GE Healthcare China, Beijing, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: GE Healthcare China, Beijing, China.
authors.forename: Ziheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: GE Healthcare China, Beijing, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China.
authors.forename: Weidan
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, China.
authors.forename: Huici
authors.initials: H
authors.lastname: Zhu
mesh_terms: D002584:Cervix Uteri / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009038:Motion; D060787:Neoplasm Grading; D010477:Perfusion; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D003287:Contrast Media
keywords: Bi-exponential model; Dynamic contrast enhancement; Intravoxel incoherent motion (IVIM); Multi-b value DWI