title: Genome-wide association study identifies loci and candidate genes for meat quality traits in Simmental beef cattle.
abstract: Improving meat quality is the best way to enhance profitability and strengthen competitiveness in beef industry. Identification of genetic variants that control beef quality traits can help breeders design optimal breeding programs to achieve this goal. We carried out a genome-wide association study for meat quality traits in 1141 Simmental cattle using the Illumina Bovine HD 770K SNP array to identify the candidate genes and genomic regions associated with meat quality traits for beef cattle, including fat color, meat color, marbling score, longissimus muscle area, and shear force. In our study, we identified twenty significant single-nucleotide polymorphisms (SNPs) (p < 1.47 × 10(-6)) associated with these five meat quality traits. Notably, we observed several SNPs were in or near eleven genes which have been reported previously, including TMEM236, SORL1, TRDN, S100A10, AP2S1, KCTD16, LOC506594, DHX15, LAMA4, PREX1, and BRINP3. We identified a haplotype block on BTA13 containing five significant SNPs associated with fat color trait. We also found one of 19 SNPs was associated with multiple traits (shear force and longissimus muscle area) on BTA7. Our results offer valuable insights to further explore the potential mechanism of meat quality traits in Simmental beef cattle.
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Xia
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Qi
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Lingyang
authors.initials: L
authors.lastname: Xu
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Lupei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. jl1@iascaas.net.cn.
authors.forename: Junya
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Science, No.2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. gaohj111@sina.com.
authors.forename: Huijiang
authors.initials: H
authors.lastname: Gao
mesh_terms: D000818:Animals; D001947:Breeding; D002417:Cattle; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D008460:Meat; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics*