title: Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy.
abstract: Despite the high potency of bilirubin as an endogenous anti-inflammatory compound, its clinical translation has been hampered because of its insolubility in water. Bilirubin-based nanoparticles that may overcome this critical issue are presented. A polyethylene glycol compound (PEG) was covalently attached to bilirubin, yielding PEGylated bilirubin (PEG-BR). The PEG-BR self-assembled into nanoscale particles with a size of approximately 110 nm, termed bilirubin nanoparticles (BRNPs). BRNPs are highly efficient hydrogen peroxide scavengers, thereby protecting cells from H2 O2 -induced cytotoxicity. In a murine model of ulcerative colitis, intravenous injection of BRNPs showed preferential accumulation of nanoparticles at the sites of inflammation and significantly inhibited the progression of acute inflammation in the colon. Taken together, BRNPs show potential for use as a therapeutic nanomedicine in various inflammatory diseases.
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
authors.forename: Yonghyun
authors.initials: Y
authors.lastname: Lee
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
authors.forename: Hyungjun
authors.initials: H
authors.lastname: Kim
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
authors.forename: Sukmo
authors.initials: S
authors.lastname: Kang
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
authors.forename: Jinju
authors.initials: J
authors.lastname: Lee
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
authors.forename: Jinho
authors.initials: J
authors.lastname: Park
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, Republic of Korea. syjon@kaist.ac.kr.
authors.forename: Sangyong
authors.initials: S
authors.lastname: Jon
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001663:Bilirubin / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000628:therapy; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D050997:Nanomedicine; D053758:Nanoparticles / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D011092:Polyethylene Glycols; D001663:Bilirubin
keywords: bilirubin; inflammation therapy; nanomedicine; nanoparticles; self-assembled nanostructures