title: Chronic pancreatitis and the composition of plasma phosphatidylcholine fatty acids.
abstract: Chronic pancreatitis (CP) is an irreversible inflammatory disorder characterized by the destruction of both exocrine and endocrine tissue. There is growing evidence that dysregulation of fatty acid (FA) metabolism is connected with many diseases; however, there are few data concerning FA composition in CP. Therefore, we analyzed FA profiles in plasma phosphatidylcholines in 96 patients with CP and in 108 control subjects (CON). The patients with CP had, in comparison with CON, increased sum of monounsaturated FA (ΣMUFA) and decreased content of polyunsaturated FA (PUFA) in both n-6 and n-3 families. Moreover, CP patients had increased indexes for delta-9, delta-6 desaturases, and fall in activity of delta-5 desaturase. Increased ratio of 16:1n-7/18:2n-6 (marker of essential n-6 FA deficiency), was more prevalent among CP patients. These changes implicated decreased fat intake, including n-3 as well as n-6 PUFA, and intrinsic changes in FA metabolism due to the alteration of delta desaturase activities.
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Zeman
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Macášek
authors.affiliation: Institute for Research and Applications of Fuzzy Modeling, CE IT4Innovations, University of Ostrava, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Burda
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Tvrzická
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic. Electronic address: marek.vecka@lf1.cuni.cz.
authors.forename: Marek
authors.initials: M
authors.lastname: Vecka
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Krechler
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Staňková
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Hrabák
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic.
authors.forename: Aleš
authors.initials: A
authors.lastname: Žák
mesh_terms: D000328:Adult; D005229:Fatty Acids, Monounsaturated / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000032:analysis* / Q000097:blood
chemical_list: D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D010713:Phosphatidylcholines
keywords: Chronic pancreatitis; Diabetes mellitus; Discriminant analysis; Fatty acid profile; Malnutrition