title: Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor.
abstract: A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. This report describes a case of a patient with hypoinsulinemic hypoglycemia and Leser-Trélat sign associated with a malignant solitary fibrous tumor with IGF2 secretion. Both conditions have improved after tumor excision.
authors.affiliation: Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP Brazil.
authors.forename: Andreia Latanza Gomes
authors.initials: AL
authors.lastname: Mathez
authors.affiliation: Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP Brazil.
authors.forename: Debora
authors.initials: D
authors.lastname: Moroto
authors.affiliation: Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP Brazil.
authors.forename: Sergio Atala
authors.initials: SA
authors.lastname: Dib
authors.affiliation: Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP Brazil.
authors.forename: Joao Roberto
authors.initials: JR
authors.lastname: de Sa
keywords: Hypoglycemia; Insulin-like growth factor 2; Seborrheic keratosis; Tumor