title: The role of giant viruses of amoebas in humans.
abstract: Since 2003, dozens of giant viruses that infect amoebas (GVA), including mimiviruses and marseilleviruses, have been discovered. These giants appear to be common in our biosphere. From the onset, their presence and possible pathogenic role in humans have been serendipitously observed or investigated using a broad range of technological approaches, including culture, electron microscopy, serology and various techniques based on molecular biology. The link between amoebal mimiviruses and pneumonia has been the most documented, with findings that fulfill several of the criteria considered as proof of viral disease causation. Regarding marseilleviruses, they have been mostly described in asymptomatic persons, and in a lymph node adenitis. The presence and impact of GVA in humans undoubtedly deserve further investigation in medicine.
authors.affiliation: IHU Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalo-Universitaire Timone, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; Aix-Marseille Univ., URMITE UM 63 CNRS 7278 IRD 198 INSERM U1095, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Colson
authors.affiliation: IHU Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalo-Universitaire Timone, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; Aix-Marseille Univ., URMITE UM 63 CNRS 7278 IRD 198 INSERM U1095, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Aherfi
authors.affiliation: IHU Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalo-Universitaire Timone, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; Aix-Marseille Univ., URMITE UM 63 CNRS 7278 IRD 198 INSERM U1095, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: La Scola
authors.affiliation: IHU Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalo-Universitaire Timone, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; Aix-Marseille Univ., URMITE UM 63 CNRS 7278 IRD 198 INSERM U1095, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France. Electronic address: didier.raoult@gmail.com.
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000048:Acanthamoeba / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D016679:Genome, Viral / Q000235:genetics; D000072139:Giant Viruses / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008199:Lymphadenitis / Q000821:virology*; D056686:Mimiviridae / Q000145:classification / Q000235:genetics; D011024:Pneumonia, Viral / Q000821:virology*
chemical_list: D004279:DNA, Viral