title: Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia.
abstract: Perioperative myocardial ischemia is common in high-risk patients. The use of interventional revascularisation or even thrombolysis is limited in this patient subset due to exceedingly high bleeding risks. Blockade of voltage-gated sodium channels (VGSC) with lidocaine had been suggested to reduce infarct size and cardiomyocyte cell death in ischemia/reperfusion models. However, the impact of lidocaine on cardiac function during sustained ischemia still remains unclear.
  
  
  
  Sustained myocardial ischemia was induced by ligation of the left anterior descending artery in 12-16 weeks old male BALB/c mice. Subcutaneous lidocaine (30 mg/kg) was used to block VGSC. Cardiac function was quantified at baseline and at 72h by conventional and speckle-tracking based echocardiography to allow high-sensitivity in vivo phenotyping. Infarct size and cardiomyocyte cell death were assessed post mortem histologically and indirectly using troponin measurements.
  
  
  
  Ischemia strongly impaired both, global systolic and diastolic function, which were partially rescued in lidocaine treated in mice. No differences regarding infarct size and cardiomyocyte cell death were observed. Mechanistically, and as shown with speckle-tracking analysis, lidocaine specifically improves residual contractility in the ischemic but not in the remote, non-ischemic myocardium.
  
  
  
  VGSC blockade with lidocaine rescues function of ischemic myocardium as a potential bridging to revascularisation in the setting of perioperative myocardial ischemia.
authors.affiliation: Cardioimmunology, Center of Molecular Cardiology, University of Zurich, Wagistr. 12, CH-8952, Schlieren, Switzerland.|Institute of Physiology, University of Zurich, Winterthurerstr. 190, CH-8057 Zurich, Switzerland.
authors.forename: Björn
authors.identifier: 0000-0002-8436-3591
authors.initials: B
authors.lastname: Müller-Edenborn
authors.affiliation: Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, Wagistr. 14, CH-8952 Schlieren, Switzerland.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kania
authors.affiliation: Center of Molecular Cardiology, University of Zurich, Wagistr. 12, CH-8952 Schlieren, Switzerland.|Laboratory of Translational Nutrition Biology, Eidgenössische Technische Hochschule Zürich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland.
authors.forename: Elena
authors.initials: E
authors.lastname: Osto
authors.affiliation: Center of Molecular Cardiology, University of Zurich, Wagistr. 12, CH-8952 Schlieren, Switzerland.|Department of Cardiology, University Heart Center, University Hospital Zurich, Raemistr. 100, CH-8001, Zurich, Switzerland.
authors.forename: Philipp
authors.initials: P
authors.lastname: Jakob
authors.affiliation: Department of Medicine, GZO-Zurich Regional Health Center, Spitalstr. 66, CH-8620, Wetzikon, Switzerland.|Department of Cardiology, University Heart Center, University Hospital Zurich, Raemistr. 100, CH-8001, Zurich, Switzerland.
authors.forename: Nazmi
authors.initials: N
authors.lastname: Krasniqi
authors.affiliation: Institute of Physiology, University of Zurich, Winterthurerstr. 190, CH-8057 Zurich, Switzerland.|Institute of Anesthesiology, University Heart Center, University Hospital Zurich, Raemistr. 100, CH-8001, Zurich, Switzerland.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Beck-Schimmer
authors.affiliation: Cardioimmunology, Center of Molecular Cardiology, University of Zurich, Wagistr. 12, CH-8952, Schlieren, Switzerland.
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Blyszczuk
authors.affiliation: Cardioimmunology, Center of Molecular Cardiology, University of Zurich, Wagistr. 12, CH-8952, Schlieren, Switzerland.|Department of Medicine, GZO-Zurich Regional Health Center, Spitalstr. 66, CH-8620, Wetzikon, Switzerland.|Department of Cardiology, University Heart Center, University Hospital Zurich, Raemistr. 100, CH-8001, Zurich, Switzerland.
authors.forename: Urs
authors.initials: U
authors.lastname: Eriksson
mesh_terms: D000818:Animals; D003971:Diastole / Q000187:drug effects; D004195:Disease Models, Animal; D004562:Electrocardiography; D008012:Lidocaine / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology*; D013599:Systole / Q000187:drug effects; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy
chemical_list: D008012:Lidocaine