title: Baroreflex Dysfunction in Prader Willi Syndrome.
abstract: Prader-Willi syndrome is a classical hypothalamic insufficiency disorder. This syndrome is often associated with cardiovascular morbidity and mortality - which could probably be attributed to autonomic dysfunction. A 21-year-old Prader Willi syndrome patient was referred for cardiovascular and autonomic function assessment. We performed a battery of tests assessing vascular structure (carotid intima thickness), vascular function (arterial stiffness indices), baroreflex sensitivity (overall integrator of short term regulation of blood pressure), blood pressure variability and autonomic tone (heart rate variability) along with autonomic reactivity tests. We observed impaired baroreflex sensitivity along with orthostatic tachycardia with normal vascular function tests. Prader- Willi syndrome patient have baroreflex dysfunction with probable afferent and/ central autonomic neural defects.
authors.affiliation: Senior Demonstrator, Department of Physiology, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Manpreet
authors.initials: M
authors.lastname: Kaur
authors.affiliation: Junior Demonstrator, Department of Physiology, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Shival
authors.initials: S
authors.lastname: Srivastav
authors.affiliation: Professor, Department of Physiology, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Jaryal
authors.affiliation: Professor, Department of Physiology, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Kishore Kumar
authors.initials: KK
authors.lastname: Deepak
keywords: Arterial stiffness; Autonomic dysfunction; Carotid intima thickness