title: There is no association between TNF-α gene polymorphisms and the risk of coronary artery heart disease: a meta-analysis.
abstract: BACKGROUND
  Coronary artery heart disease (CAD) is a group of complex diseases, including coronary atherosclerosis, myocardial infarction and sudden cardiac death. CAD is also widely accepted as a chronic inflammatory disease. Studies show that pro-inflammatory tumor necrosis factor-alpha (TNF-α) is involved in the CAD pathological pathway and is a reliable predictor of cardiovascular disease. However, the association between TNF-α polymorphisms and CAD risk is still unclear. In this meta-analysis, we investigated the relationship between TNF-α polymorphisms and CAD risk.
  
  
  METHODS
  From EMBASE, Web of science, EBSCO, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases 7525 articles were selected in our study. A meta-analysis on the associations between the T-1031C, C-857T and C-863A polymorphisms and CAD risk was carried out by comparing five genetic models.
  
  
  RESULTS
  In this systematic review 14 studies from six English articles and 1 Chinese article were analyzed. The pooled population included 16,774 subjects (8351 cases and 8423 controls). Our results showed that three polymorphisms (T-1031C, C-857T and C-863A) have no association with CAD risk.
  
  
  CONCLUSIONS
  Our results indicated that T-1031C, C-857T and C-863A polymorphisms are not associated with CAD risk.
authors.affiliation: Department of Cardiology, Jinan 4th Hospital, Jinan, China.
authors.forename: Fengtian
authors.initials: F
authors.lastname: Huangfu
authors.affiliation: Department of Healthcare, Jinan 4th Hospital, Jinan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Jinan 4th Hospital, Jinan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shandong University School of Medicine, Jinan, China.
authors.forename: Longqian
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Emergency, Jinan 4th Hospital, Jinan, China - zgjn2015@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
mesh_terms: D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology
chemical_list: D014409:Tumor Necrosis Factor-alpha