title: [Basic carboxypeptidases of blood: significance for coagulology].
abstract: This review considers the basic metallocarboxypeptidases of human blood and their role in coagulologic disorders. In includes information on the history of the discovery and biological characteristics of potential enzymes-regulators of the fibrinolytic process: carboxypeptidase U and carboxypeptidase N. Certain attention is paid to the biochemical mechanisms and the main modern concepts of the antifibrinolytic effects of these enzymes.
authors.affiliation: Russian Research Institute of Haematology and Transfusiology, Saint Petersburg, Russia.
authors.forename: А V
authors.initials: АV
authors.lastname: Timofeev
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000201:enzymology; D025901:Carboxypeptidase B2 / Q000737:chemistry / Q000378:metabolism; D002268:Carboxypeptidases / Q000097:blood* / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D001121:Lysine Carboxypeptidase / Q000737:chemistry / Q000378:metabolism
chemical_list: D005337:Fibrin; D002268:Carboxypeptidases; C585364:CPB2 protein, human; D025901:Carboxypeptidase B2; D001121:Lysine Carboxypeptidase
keywords: basic carboxypeptidases; clot; fibrin; fibrinolysis; plasmin