title: Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction.
abstract: BACKGROUND
  Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications.
  
  
  METHODS
  We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups: the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA.
  
  
  RESULTS
  On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004).
  
  
  CONCLUSIONS
  The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.
authors.affiliation: Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Barbarash
authors.affiliation: Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Gruzdeva
authors.affiliation: Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation. evg.uchasova@yandex.ru.
authors.forename: Evgenya
authors.initials: E
authors.lastname: Uchasova
authors.affiliation: Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Dyleva
authors.affiliation: Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Belik
authors.affiliation: State Budget Educational Institution of Higher Professional Education, Siberian State Medical University of the Russian Federation Ministry of Health, Tomsk, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Akbasheva
authors.affiliation: Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation.
authors.forename: Victoria
authors.initials: V
authors.lastname: Karetnikova
authors.affiliation: Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation.
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Shilov
mesh_terms: D019540:Area Under Curve; D016022:Case-Control Studies; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000000981:diagnostic imaging; D020097:Natriuretic Peptide, Brain / Q000097:blood; D016017:Odds Ratio; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D017481:Receptors, Somatostatin / Q000097:blood*
chemical_list: D010446:Peptide Fragments; D017481:Receptors, Somatostatin; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Myocardial infarction; NT-proBNP; sST2