title: Prevalence of Osteoporosis and Low Bone Mass in Older Chinese Population Based on Bone Mineral Density at Multiple Skeletal Sites.
abstract: Diagnosis of osteoporosis is based on bone mineral density (BMD) measurement, which is site dependent and commonly discordant between measurement sites. We aimed to determine the prevalence of osteoporosis diagnosed based on BMD T-scores measured by dual-energy x-ray absorptiometry (DXA) at different sites: the lumbar spine (LS) alone, femoral neck (FN) alone, or both. A total of 1712 women and 2028 men with LS and FN BMD measurements were enrolled. Over 50% discordance was found between osteoporosis classifications based on T-scores measured at the LS and FN. Use of the lowest T-scores measured at both the LS and right and left FN (rather than one site) significantly increased the prevalence of osteoporosis from 4.03 to 10.75% in postmenopausal women and 1.82 to 4.29% in men aged ≧50 years (p < 0.001). The trends of overall and age-adjusted prevalence of osteoporosis were similar in women and men. Osteoporosis was diagnosed at a higher rate if the USA reference rather than the Asia reference was used to calculate the T-score (26.64% vs. 10.75%). In conclusion, diagnosis based on the lowest T-score from multiple site BMD measurement can increase the prevalence of osteoporosis, demonstrating the higher sensitivity of the multiple site measurement strategy.
authors.affiliation: Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, Republic of China.
authors.forename: Yi-Chien
authors.initials: YC
authors.lastname: Lu
authors.affiliation: Department of Health Management Center, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan, Republic of China.|Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan, Republic of China.|Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, Republic of China.
authors.forename: Ying Chin
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Biostatistics Center, Taipei Medical University, Taipei 110, Taiwan, Republic of China.|Graduate Institute of Nursing, Taipei Medical University, Taipei 110, Taiwan, Republic of China.
authors.forename: Yen-Kuang
authors.initials: YK
authors.lastname: Lin
authors.affiliation: Department of Automatic Control Engineering, Feng Chia University, Taichung 407, Taiwan, Republic of China.
authors.forename: Yi-Jui
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: Department of Physical Medicine and Rehabilitation, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan, Republic of China.|Graduate Institute of Injury Prevention and Control, College of Public Health and Nutrition, Taipei Medical University, Taipei 110, Taiwan, Republic of China.
authors.forename: Kwang-Hwa
authors.initials: KH
authors.lastname: Chang
authors.affiliation: Department of Radiology, Taiwan Adventist Hospital, Taipei 105, Taiwan, Republic of China.
authors.forename: Poon-Ung
authors.initials: PU
authors.lastname: Chieng
authors.affiliation: Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, Republic of China.|Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan, Republic of China.
authors.forename: Wing P
authors.initials: WP
authors.lastname: Chan
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015519:Bone Density; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015995:Prevalence; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology