title: Cardiac allograft vasculopathy: optical coherence guided innovative treatment options with the bioresorbable vascular scaffold: proof of concept.
abstract: The aim of our work was to assess a novel interventional therapy option in cardiac allograft vasculopathy (CAV), a complex form of coronary disease presenting only in heart transplant (HTx) recipients. It is typically a rapidly progressing phenomenon, affecting the entire coronary circulation causing diffuse, severe coronary lesions and has no one unique cause. Treatment options are limited, but where eligible, palliation via percutaneous revascularization (PCI) mainly using new generation drug eluting stents (DES) is recommended. Our working group sought to assess outcomes of CAV PCI using an Absorb (Abbott Vascular, Santa Clara, CA, USA) fully bioresorbable, everolimus eluting vascular scaffold (BVS), under optical coherence tomography (OCT) guidance. Our initial, proof-of-concept case showed a late CAV, macrophage and foam-cell rich lesion, with typical asymmetric intimal hyperplasia and contralateral thin-cap fibroatheroma formation. Post-PCI OCT showed underexpansion, requiring aggressive postdilatation. Ninety-day follow-up CT angiogram identified the scaffold and displayed a patent lumen of the device. BVS use thus seems eligible in CAV, yet needs proper, meticulous implantation. Use may also delay CAV progression as lesion healing is promoted, with restoration of vasomotion and a natural increase in vascular lumen. Furthermore, the chronically present vascular irritation surrounding stent/scaffold struts may subside, as no permanent metal is present as an increased substrate for inflammation. To assess full efficacy, further studies will be needed.
authors.affiliation: Semmelweis University, Heart and Vascular Center, Budapest, Hungary - edes789@gmail.com.
authors.forename: István F
authors.initials: IF
authors.lastname: Édes
authors.forename: Ágota
authors.initials: Á
authors.lastname: Hajas
authors.forename: Balázs
authors.initials: B
authors.lastname: Sax
authors.forename: Andrea
authors.initials: A
authors.lastname: Bartykowszki
authors.forename: Dávid
authors.initials: D
authors.lastname: Becker
authors.forename: Béla
authors.initials: B
authors.lastname: Merkely
mesh_terms: D020341:Absorbable Implants / Q000009:adverse effects*; D064591:Allografts; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D003324:Coronary Artery Disease / Q000601:surgery*; D016027:Heart Transplantation; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods; D054457:Tissue Scaffolds / Q000009:adverse effects*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014652:Vascular Diseases / Q000000981:diagnostic imaging* / Q000209:etiology*