title: Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related Structures.
abstract: A unified approach for the asymmetric syntheses of medicinally important isoindolinones (S)-PD 172938 and (R)-JM 1232 has been accomplished via a Cu(I)-PYBOX-diPh catalyzed highly enantioselective (up to 99% ee) alkynylation/lactamization sequence in a one-pot fashion. The overall sequence involves one C-C and two C-N bond forming events in one pot starting from inexpensive starting material in ambient reaction conditions.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhopal, MP - 462 066, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Suneja
authors.forename: Vishnumaya
authors.initials: V
authors.lastname: Bisai
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhopal, MP - 462 066, India.|Indian Institute of Technology Kanpur , Kanpur, UP - 208 016, India.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh