title: The dog aging project: translational geroscience in companion animals.
abstract: Studies of the basic biology of aging have identified several genetic and pharmacological interventions that appear to modulate the rate of aging in laboratory model organisms, but a barrier to further progress has been the challenge of moving beyond these laboratory discoveries to impact health and quality of life for people. The domestic dog, Canis familiaris, offers a unique opportunity for surmounting this barrier in the near future. In particular, companion dogs share our environment and play an important role in improving the quality of life for millions of people. Here, we present a rationale for increasing the role of companion dogs as an animal model for both basic and clinical geroscience and describe complementary approaches and ongoing projects aimed at achieving this goal.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, USA. kaeber@uw.edu.
authors.forename: Matt
authors.initials: M
authors.lastname: Kaeberlein
authors.affiliation: Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Creevy
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, USA.
authors.forename: Daniel E L
authors.initials: DE
authors.lastname: Promislow
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005853:Geriatrics; D006801:Humans; D023421:Models, Animal; D011788:Quality of Life