title: [Prognostic and Therapeutic Significance of Molecular Subtyping on Aged Patient with Advanced Diffuse Large B Cell Lymphoma---A Case Report].
abstract: OBJECTIVE
  To analyze the clinical course of a very elderly patient with advanced diffuse large B cell lymphoma (DLBCL), so as to explore the incidence, prognosis and treatment of DLBCL and to analyse the prognostic and therapeutic significance of molecular subtype.
  
  
  METHODS
  The clinical history, auxiliary examinations, clinical diagnostic standards, therapeutic methods, biopsy and autopsy of this patient were retrospectively analyzed; the incidence, current treatment status, molecular biological features, and prognostic and therapeutic significance of molecular subtype were studied.
  
  
  RESULTS
  After admission, this patient was diagnosed as non-GCB DLBCL, NOS, stage IV B and in the high risk group (IPI = 5, ECOG = 2). She achieved a decent partial response after many times of imunochemotherapy, but his disease status soon progressed. The liver occupying biopsy revealed non-GCB, while the spleen tumor pathology revealed GCB; pathological typing of these two methods was completely opposite. Autopsy pathological diagnosis showed that the death causes included extensive tumor metastasis, dyscrasia and respiratory circle failure.
  
  
  CONCLUSIONS
  Incidence of aged patients with DLBCL is high, and the disease is aggressive; the treatment is low responsive and difficult, and new therapeutic methods are needed. Gene expression profile (GEP) can provide molecular subtype and potential pathogenic mechanism, which can promote the development of new targeted therapy and individualized treatment.
authors.affiliation: Department of Geriatric Hematology, General Hospital of Chinese PLA, Medical School of Chinese PLA, Beijing 100853, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Xin
authors.affiliation: Department of Geriatric Hematology, General Hospital of Chinese PLA, Medical School of Chinese PLA, Beijing 100853, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Geriatric Hematology, General Hospital of Chinese PLA, Medical School of Chinese PLA, Beijing 100853, China.
authors.forename: Xue-Chun
authors.initials: XC
authors.lastname: Lu
authors.affiliation: The First Clinic, Administration Burean of the General Logistics Department, Chinese PLA, Beijing 100842, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yin
authors.affiliation: The First Clinic, Administration Burean of the General Logistics Department, Chinese PLA, Beijing 100842, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Geriatric Hematology, General Hospital of Chinese PLA, Medical School of Chinese PLA, Beijing 100853, China. E-mail: bjzhl202_cn@sina.com.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Zhu
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis