title: Diffusion tensor imaging study in Duchenne muscular dystrophy.
abstract: BACKGROUND
  Duchenne muscular dystrophy (DMD) is a progressive muscle disorder associated with an intellectual deficit which is non-progressive. The aim of this study was to investigate brain microstructural changes in DMD and to explore the relationship between such changes and cognitive impairment.
  
  
  METHODS
  All participants (12 DMD patients, 14 age-matched healthy boys), intelligence quotients (IQs) [both full (FIQ) and verbal (VIQ)] were evaluated using the Wechsler intelligence scale for children China revised (WISC-CR) edition, and brain gray matter (GM) and white matter (WM) changes were mapped using diffusion tensor imaging (DTI) with fractional anisotropy (FA). The differences between groups were analyzed using the t-test and the association of cognition with neuroimaging parameters was evaluated using Pearson's correlation coefficient.
  
  
  RESULTS
  Compared to the normal controls, the DMD group had lower FIQ (82.0±15.39 vs. 120.21±16.06) and significantly lower splenium of corpus callosum (CC) FA values (P<0.05). Splenium of CC FA was positively correlated with VIQ (r=0.588, P=0.044).
  
  
  CONCLUSIONS
  There were microstructural changes of splenium of CC in DMD patients, which was associated with cognitive impairment.
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Fu
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Yuru
authors.initials: Y
authors.lastname: Dong
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Xuetao
authors.initials: X
authors.lastname: Mu
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Weihai
authors.initials: W
authors.lastname: Xu
authors.affiliation: 1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
authors.forename: Shiwen
authors.initials: S
authors.lastname: Wu
keywords: Duchenne muscular dystrophy (DMD); cognitive impairment; diffusion tensor imaging (DTI)