title: The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism.
abstract: OBJECTIVE
  To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats.
  
  
  METHODS
  Twenty-four male Sprague-Dawley rats were divided into four groups, control, P/R, P/R+DMSO and P/R+D. 3ml blood specimens were collected from vena cava inferior in order to determine serum MDA, IMA, TAS, TOS and OSI values, and penile tissue was taken for histopathological examination in control group. Priapism was induced in P/R group. After 1h, priapism was concluded and 30 min reperfusion was performed. In P/R+DMSO group 1ml/kg DMSO was administered intraperitoneally 30 min before reperfusion, while in P/R+D group 10mg/kg dipyridamole was administered intraperitoneally 30 min before reperfusion. Blood and penis specimens were collected after the end of 30 min reperfusion period. Sinusoidal area (μm2), tears in tunica albuginea and injury parameters in sinusoidal endothelium of penis were investigated.
  
  
  RESULTS
  Histopathological examination revealed no significant changes in term of sinusoidal area. A decrease in tears was observed in P/R+D group compared to P/R group (p<0.05). Endothelial injury decreased in P/R+D group compared to P/R group (p>0.05). There were no significant differences in MDA and IMA values between groups. A significant increase in TOS and OSI values was observed in P/R+D group compared to P/R group. A significant decrease in TAS levels was observed in P/R+D group compared to the P/R group.
  
  
  CONCLUSIONS
  The administration of dipyridamole before reperfusion in ischemic priapism model has a potential protective effect against histopathological injury of the penis.
authors.affiliation: Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ersagun
authors.initials: E
authors.lastname: Karaguzel
authors.affiliation: Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Cemil
authors.initials: C
authors.lastname: Bayraktar
authors.affiliation: Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Kutlu
authors.affiliation: Department of Histology and Embryology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Yulug
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.affiliation: Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ali Ertan
authors.initials: AE
authors.lastname: Okatan
authors.affiliation: Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Colak
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Ozer
authors.affiliation: Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ilke O
authors.initials: IO
authors.lastname: Kazaz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D004176:Dipyridamole / Q000494:pharmacology*; D004195:Disease Models, Animal; D007511:Ischemia / Q000517:prevention & control*; D019194:Ischemic Preconditioning / Q000379:methods; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000098:blood supply* / Q000473:pathology; D011317:Priapism / Q000473:pathology / Q000517:prevention & control*; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control*; D015203:Reproducibility of Results; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D012709:Serum Albumin; D014665:Vasodilator Agents; C561522:ischemia-modified albumin; D008315:Malondialdehyde; D004176:Dipyridamole; D000075462:Serum Albumin, Human