title: Bone marrow cellularity MRI calculation and correlation with bone marrow biopsy.
abstract: OBJECTIVE
  To calculate bone marrow cellularity from MRI and correlate with bone marrow biopsy.
  
  
  METHODS
  Twenty-seven lymphoma patients with staging bone marrow biopsies and lumbar MRI were reviewed. Cellularity was calculated from T1 signal intensity measurements=100 - {[(marrow - CSF)/(subcutaneous fat - CSF)] X 100}.
  
  
  RESULTS
  The histologic cellularities demonstrated significant correlation with iliac bone MRI cellularity (r=0.59, P=.001). Cellularities increased from T11 to S1. Cellularity decreased with age=67.6 - (age X 0.36).
  
  
  CONCLUSIONS
  Marrow cellularity from MRI shows statistically significant correlation with biopsy and significant differences between vertebral levels and changes with age.
authors.affiliation: Department of Radiology, Keck School of Medicine, University of Southern California. Electronic address: matcuk@usc.edu.
authors.forename: George R
authors.initials: GR
authors.lastname: Matcuk
authors.affiliation: Department of Pathology, Keck School of Medicine, University of Southern California.
authors.forename: Imran
authors.initials: I
authors.lastname: Siddiqi
authors.affiliation: Department of Radiology, Keck School of Medicine, University of Southern California.
authors.forename: Steven
authors.initials: S
authors.lastname: Cen
authors.affiliation: Department of Pathology, Keck School of Medicine, University of Southern California.
authors.forename: Ashley
authors.initials: A
authors.lastname: Hagiya
authors.affiliation: Department of Medicine, Keck School of Medicine, University of Southern California.
authors.forename: Reese
authors.initials: R
authors.lastname: Isaacson
authors.affiliation: Department of Pathology, Keck School of Medicine, University of Southern California.
authors.forename: Russell
authors.initials: R
authors.lastname: Brynes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000473:pathology; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies
keywords: Biopsy; Bone marrow; Cellularity; MRI