title: Preparation and application of magnetic molecularly imprinted nanoparticles for the selective extraction of osthole in Libanotis Buchtomensis herbal extract.
abstract: In this work, novel magnetic molecularly imprinted polymers were prepared for the selective extraction of osthole from Libanotis Buchtomensis herbal extract. During the synthesis process, double bonds grafted on the surface of Fe3 O4 nanoparticles could not only drive the temple molecules to locate onto the surface of vinyl-functionalized magnetic nanoparticles by π-π conjugation, which makes the distribution of binding sites ordered, but also direct the occurrence of imprinting polymerization at the surface of magnetic nanoparticles by the copolymerization of vinyl terminal groups with functional monomers and cross-linking agent. The characteristics of the resulting polymers were evaluated by transmission electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and vibrating sample magnetometry. Adsorption kinetics, isotherms, selectivity, reproducibility, and reusability were discussed, which suggest that the obtained nanomaterials possess rapid binding kinetics, high adsorption capacity of 17.65 mg/g, and favorable selectivity for the target molecule. Satisfactory reproducibility and reusability were verified as well. Meanwhile, the resultant imprinted nanoparticles were successfully applied to selectively separate osthole from the herbal extract, which show great potential in extracting active ingredients from traditional Chinese medicine.
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an, China.|School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Gaiyan
authors.initials: G
authors.lastname: He
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an, China.|School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an, China.|School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hao
authors.affiliation: School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Shi
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Gao
mesh_terms: D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D054802:Molecular Imprinting; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification*; D013499:Surface Properties
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D058185:Magnetite Nanoparticles; D010936:Plant Extracts; C046627:osthol
keywords: Erbal extracts; Magnetic separation; Osthole; Selective extraction; Surface imprinting