title: [Single Nucleotide Polymorphisms in T-Cadherin Gene (CDH13) Have Cumulative Effect on Body Mass in Patients With Ischemic Heart Disease].
abstract: BACKGROUND
  Low adiponectin concentration observed in obese patients is associated with a high risk of metabolic disorders and cardiovascular diseases and could be related to single nucleotide polymorphisms (SNPs) in T-cadherin gene (CDH13). T-cadherin is a receptor for adiponectin and low-density lipoprotein. Aim of this study was to investigate association of CDH13 SNPs with the development of obesity in patients with ischemic heart disease (IHD).
  
  
  RESULTS
  We established a statistically significant correlation between the number of minor alleles of rs11646213, rs4783244 and rs12444338 in CDH13 gene with body mass index: patients with smaller number of minor alleles tended to have normal body weight (odds ratio 3.03, 95% confidence interval 1.03-8.87).
  
  
  CONCLUSIONS
  The obtained results are indicative of the cumulative effect of SNPs in CDH13 (rs11646213, rs4783244, rs12444338) on BMI in patients with IHD.
authors.forename: A V
authors.initials: AV
authors.lastname: Balatsky
authors.forename: D Yu
authors.initials: DY
authors.lastname: Konovalov
authors.forename: L M
authors.initials: LM
authors.lastname: Samokhodskaya
authors.forename: T N
authors.initials: TN
authors.lastname: Kochegura
authors.forename: K A
authors.initials: KA
authors.lastname: Rubina
authors.forename: V A
authors.initials: VA
authors.lastname: Tkachuk
mesh_terms: D000483:Alleles; D015992:Body Mass Index; D015820:Cadherins; D003324:Coronary Artery Disease; D005838:Genotype; D006801:Humans; D008077:Lipoproteins, LDL; D017202:Myocardial Ischemia; D009765:Obesity; D020641:Polymorphism, Single Nucleotide
chemical_list: D015820:Cadherins; C099972:H-cadherin; D008077:Lipoproteins, LDL