title: [Autoimmune hepatitis induced by isotretionine].
abstract: We describe a case of a teenage patient with the diagnosis of drug induced autoimmune hepatitis. The patient is a 16 years old female, with the past medical history of Hashimotoâ€™s hypothyroidism controlled with levothyroxine, who started treatment with Isotretionin (Â®Accutane) 20 mg q/12 hours for a total of 3 months for the treatment of severe acne. The physical examination was within normal limits and the results of the laboratory exams are: Baseline values of ALT 28 U/L, AST 28 U/L. Three months later: AST 756 U/L, ALT 1199U/L, alkaline phosphatase 114 U/L, with normal bilirrubin levels throughout the process. The serology studies were negative for all viral hepatitis; ANA titers were positive (1/160) and igG levels were also elevated. A liver biopsy was performed, and was compatible with the diagnosis of autoimmune hepatitis. Corticosteroid therapy was started with Prednisone 40 mg per day one week after stopping the treatment with isotretionin, observing an improvement in the laboratory values. We describe this case and review the world literature since there are no reported cases of Isotretinoin-induced autoimmune hepatitis.
authors.affiliation: Universidad Peruana Cayetano Heredia. Lima, Perú.
authors.forename: Patricia
authors.initials: P
authors.lastname: Guzman Rojas
authors.affiliation: Universidad Nacional Mayor de San Marcos. Lima, Perú.
authors.forename: Roxana
authors.initials: R
authors.lastname: Gallegos Lopez
authors.affiliation: Universidad Peruana Cayetano Heredia. Lima, Perú.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ciliotta Chehade
authors.affiliation: Clínica Anglo Americana. Lima, Perú.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Scavino
authors.affiliation: Egredao de Henry Ford Hospital, EEUU.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Morales
authors.affiliation: Clínica Anglo Americana. Lima, Perú; Facultad de Medicina de la Universidad Peruana Cayetano Heredia. Lima, Perú.
authors.forename: Martín
authors.initials: M
authors.lastname: Tagle
mesh_terms: D000293:Adolescent; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin