title: Diagnostic accuracy of skin-prick testing for allergic rhinitis: a systematic review and meta-analysis.
abstract: BACKGROUND
  Allergic rhinitis is the most common form of allergy worldwide. The accuracy of skin testing for allergic rhinitis is still debated. Our primary objective was to evaluate the diagnostic accuracy of skin-prick testing for allergic rhinitis using the nasal provocation as the reference standard. We also evaluated the diagnostic accuracy of intradermal testing as a secondary objective.
  
  
  METHODS
  We searched EBM Reviews from 2005 to March 2015; Embase from 1980 to March 2015; and Ovid MEDLINE(R) from 1946 to until March 2015. We included any study with at least 10 subjects including children. We excluded non-English studies. We performed data extraction and quality assessment using the QUADAS-2 tool.
  
  
  RESULTS
  We meta-analysed seven studies assessing the accuracy of skin-prick testing using the bivariate random-effects model, including a total of 430 patients. The pooled estimate for sensitivity and specificity for skin-prick testing was 85 and 77 % respectively. We did not pool results for intradermal testing due to few number of studies (n = 4), each with very small sample size. Of these, two evaluated the accuracy of intradermal testing in confirming skin-prick testing results, with sensitivity ranging from 27 to 50 % and specificity ranging from 60 to 100 %. The other two evaluated the accuracy of intradermal testing as a stand-alone test for diagnosing allergic rhinitis with sensitivity ranging from 60 to 79 % and specificity ranging from 68 to 69 %.
  
  
  CONCLUSIONS
  Findings from this review suggest that skin-prick testing is accurate in discriminating subjects with or without allergic rhinitis.
authors.affiliation: Health Quality Ontario, 130 Bloor Street West, Toronto, ON M5S 1N5 Canada.
authors.forename: Immaculate F
authors.initials: IF
authors.lastname: Nevis
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Binkley
authors.affiliation: Health Quality Ontario, 130 Bloor Street West, Toronto, ON M5S 1N5 Canada ; Dalla Lana School of Public Health, University of Toronto, Toronto, ON Canada.
authors.forename: Conrad
authors.initials: C
authors.lastname: Kabali
keywords: Allergic rhinitis; Diagnostic accuracy; Intradermal testing; Meta-analysis; Review; Skin-prick testing