title: Association of serum leptin levels with central arterial stiffness in coronary artery disease patients.
abstract: BACKGROUND
  Serum adipokines have roles in the development of arterial stiffness. Our aim was to investigate the relationship of leptin and the surrogate marker carotid-femoral pulse wave velocity (cfPWV) in coronary artery disease (CAD) patients.
  
  
  METHODS
  Fasting blood samples were obtained from 105 CAD patients. cfPWV was measured with the SphygmoCor system. A cfPWV > 10 m/s was defined as high arterial stiffness, and ≤ 10 m/s as low arterial stiffness.
  
  
  RESULTS
  Thirty-seven patients (35.2 %) had high arterial stiffness, and had a higher percentage of diabetes (P = 0.001), hypertension (P = 0.010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0.002) compared to patients with low arterial stiffness. Serum leptin levels correlated with the number of angiographically documented stenotic coronary artery vessels (P < 0.001). After adjusting for factors significantly associated with arterial stiffness, multivariate logistic regression analysis showed that leptin (odds ratio = 1.026, 95 % confidence interval: 1.002-1.051, P = 0.037) was a significant independent predictor of arterial stiffness.
  
  
  CONCLUSIONS
  Increasing serum concentration of leptin correlated positively with the total number of stenotic coronary arteries, and serum leptin level may predict the development of arterial stiffness in CAD patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.|School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Jen-Pi
authors.initials: JP
authors.lastname: Tsai
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan.|Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Ji-Hung
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Chen
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Chiu-Fen
authors.initials: CF
authors.lastname: Yang
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Chen
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan. gee.lily@msa.hinet.net.|Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. gee.lily@msa.hinet.net.
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D023921:Coronary Stenosis / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D063177:Pulse Wave Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D015854:Up-Regulation; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D020738:Leptin
keywords: Arterial stiffness; Carotid-femoral pulse wave velocity; Coronary artery disease; Leptin