title: The role of natural polyphenols in cell signaling and cytoprotection against cancer development.
abstract: The cytoprotective and anticancer action of dietary in-taken natural polyphenols has for long been attributed only to their direct radical scavenging activities. Currently it is well supported that those compounds display a broad spectrum of biological and pharmacological outcomes mediated by their complex metabolism, interaction with gut microbiota as well as direct interactions of their metabolites with key cellular signaling proteins. The beneficial effects of natural polyphenols and their synthetic derivatives are extensively studied in context of cancer prophylaxis and therapy. Herein we focus on cell signaling to explain the beneficial role of polyphenols at the three stages of cancer development: we review the recent proceedings about the impact of polyphenols on the cytoprotective antioxidant response and their proapoptotic action at the premalignant stage, and finally we present data showing how phenolic acids (e.g., caffeic, chlorogenic acids) and flavonols (e.g., quercetin) hamper the development of metastatic cancer.
authors.affiliation: Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Dorodna 16, 03-195 Warsaw, Poland. Electronic address: h.lewandowska@ichtj.waw.pl.
authors.forename: Hanna
authors.initials: H
authors.lastname: Lewandowska
authors.affiliation: Division of Chemistry, Bialystok University of Technology, Zamenhofa 29, 15-435 Bialystok, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Kalinowska
authors.affiliation: Division of Chemistry, Bialystok University of Technology, Zamenhofa 29, 15-435 Bialystok, Poland.
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Lewandowski
authors.affiliation: Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Dorodna 16, 03-195 Warsaw, Poland.
authors.forename: Tomasz M
authors.initials: TM
authors.lastname: Stępkowski
authors.affiliation: Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Dorodna 16, 03-195 Warsaw, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Brzóska
mesh_terms: D020533:Angiogenesis Inhibitors / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D016588:Anticarcinogenic Agents / Q000378:metabolism / Q000627:therapeutic use*; D017209:Apoptosis; D001343:Autophagy; D063646:Carcinogenesis; D002934:Cinnamates / Q000378:metabolism / Q000627:therapeutic use*; D000072001:Diet, Healthy; D044127:Epigenesis, Genetic; D005419:Flavonoids / Q000378:metabolism / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D009369:Neoplasms / Q000178:diet therapy / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009389:Neovascularization, Pathologic / Q000178:diet therapy / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D059808:Polyphenols / Q000378:metabolism / Q000627:therapeutic use; D011230:Precancerous Conditions / Q000178:diet therapy / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D015398:Signal Transduction
chemical_list: D020533:Angiogenesis Inhibitors; D016588:Anticarcinogenic Agents; D002934:Cinnamates; D005419:Flavonoids; D016166:Free Radical Scavengers; D059808:Polyphenols
keywords: Anticancer; Antioxidant; Caffeic acid; Chlorogenic acid; Phenolic compounds; Quercetin