title: State of the art. Autologous fat graft and adipose tissue-derived stromal vascular fraction injection for hand therapy in systemic sclerosis patients.
abstract: Systemic sclerosis is an autoimmune disease characterized by sclerosis (hardening) of the skin and deep viscera associated with microvascular functional and structural alteration, which leads to chronic ischemia. In the hands of patients, ischemic and fibrotic damages lead to both pain and functional impairment. Hand disability creates a large burden in professional and daily activities, with social and psychological consequences. Currently, the proposed therapeutic options for hands rely mainly on hygienic measures, vasodilatator drugs and physiotherapy, but have many constraints and limited effects. Developing an innovative therapeutic approach is crucial to reduce symptoms and improve the quality of life. The discovery of adult stem cells from adipose tissue has increased the interest to use adipose tissue in plastic and regenerative surgery. Prepared as freshly isolated cells for immediate autologous transplantation, adipose tissue-derived stem cell therapy has emerged as a therapeutic alternative for the regeneration and repair of damaged tissues. We aim to update literature in the interest of autologous fat graft or adipose derived from stromal vascular fraction cell-based therapy for the hands of patients who suffer from systemic sclerosis.
authors.affiliation: Service de médecine interne, hôpital Nord, Assistance publique-Hôpitaux de Marseille (AP-HM), 13915 Marseille cedex 05, France.
authors.forename: P
authors.initials: P
authors.lastname: Guillaume-Jugnot
authors.affiliation: Service de médecine interne, gériatrie et thérapeutique, hôpital de la Timone, AP-HM, 13385 Marseille cedex 05, France.
authors.forename: A
authors.initials: A
authors.lastname: Daumas
authors.affiliation: Laboratoire de culture et thérapie cellulaire, Inserm CBT-1409, hôpital de la Conception, AP-HM, 13385 Marseille cedex 05, France.
authors.forename: J
authors.initials: J
authors.lastname: Magalon
authors.affiliation: Service de médecine interne, hôpital Nord, Assistance publique-Hôpitaux de Marseille (AP-HM), 13915 Marseille cedex 05, France.
authors.forename: N
authors.initials: N
authors.lastname: Sautereau
authors.affiliation: Laboratoire de culture et thérapie cellulaire, Inserm CBT-1409, hôpital de la Conception, AP-HM, 13385 Marseille cedex 05, France.
authors.forename: J
authors.initials: J
authors.lastname: Veran
authors.affiliation: Service de chirurgie plastique et réparatrice, hôpital de la Conception, AP-HM, 13385 Marseille cedex 05, France.
authors.forename: G
authors.initials: G
authors.lastname: Magalon
authors.affiliation: Laboratoire de culture et thérapie cellulaire, Inserm CBT-1409, hôpital de la Conception, AP-HM, 13385 Marseille cedex 05, France; Inserm UMR 1076 Vascular Research Centre of Marseille, Aix-Marseille université, 13385 Marseille cedex 05, France.
authors.forename: F
authors.initials: F
authors.lastname: Sabatier
authors.affiliation: Service de médecine interne, hôpital Nord, Assistance publique-Hôpitaux de Marseille (AP-HM), 13915 Marseille cedex 05, France; Inserm UMR 1076 Vascular Research Centre of Marseille, Aix-Marseille université, 13385 Marseille cedex 05, France. Electronic address: b.granel@ap-hm.fr.
authors.forename: B
authors.initials: B
authors.lastname: Granel
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D053687:Adult Stem Cells / Q000378:metabolism / Q000637:transplantation*; D001773:Blood Cells / Q000637:transplantation; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000378:metabolism; D042783:Endothelial Cells / Q000637:transplantation; D006227:Hand Deformities, Acquired / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007267:Injections; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D015187:Lipectomy; D008264:Macrophages / Q000637:transplantation; D045164:Mesenchymal Stem Cell Transplantation; D020286:Pericytes / Q000637:transplantation; D012595:Scleroderma, Systemic / Q000150:complications / Q000628:therapy*; D017154:Stromal Cells / Q000378:metabolism / Q000637:transplantation; D020858:Tissue and Organ Harvesting; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins
keywords: Adipose tissue; Cell therapy; Regenerative medicine; Stromal vascular fraction; Systemic sclerosis