title: Synthesis and characterization of conductive, biodegradable, elastomeric polyurethanes for biomedical applications.
abstract: Biodegradable conductive polymers are currently of significant interest in tissue repair and regeneration, drug delivery, and bioelectronics. However, biodegradable materials exhibiting both conductive and elastic properties have rarely been reported to date. To that end, an electrically conductive polyurethane (CPU) was synthesized from polycaprolactone diol, hexadiisocyanate, and aniline trimer and subsequently doped with (1S)-(+)-10-camphorsulfonic acid (CSA). All CPU films showed good elasticity within a 30% strain range. The electrical conductivity of the CPU films, as enhanced with increasing amounts of CSA, ranged from 2.7 ± 0.9 × 10(-10) to 4.4 ± 0.6 × 10(-7) S/cm in a dry state and 4.2 ± 0.5 × 10(-8) to 7.3 ± 1.5 × 10(-5) S/cm in a wet state. The redox peaks of a CPU1.5 film (molar ratio CSA:aniline trimer = 1.5:1) in the cyclic voltammogram confirmed the desired good electroactivity. The doped CPU film exhibited good electrical stability (87% of initial conductivity after 150 hours charge) as measured in a cell culture medium. The degradation rates of CPU films increased with increasing CSA content in both phosphate-buffered solution (PBS) and lipase/PBS solutions. After 7 days of enzymatic degradation, the conductivity of all CSA-doped CPU films had decreased to that of the undoped CPU film. Mouse 3T3 fibroblasts proliferated and spread on all CPU films. This developed biodegradable CPU with good elasticity, electrical stability, and biocompatibility may find potential applications in tissue engineering, smart drug release, and electronics. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2305-2314, 2016.
authors.affiliation: Department of Bioengineering, University of Texas at Arlington, Arlington, Texas.|Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Cancan
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Yepez
authors.affiliation: Department of Material Science and Engineering, University of Texas at Arlington, Arlington, Texas.
authors.forename: Zi
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Department of Material Science and Engineering, University of Texas at Arlington, Arlington, Texas.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bugarin
authors.affiliation: Department of Bioengineering, University of Texas at Arlington, Arlington, Texas.|Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hong
mesh_terms: D016475:3T3 Cells; D000818:Animals; D063566:Biodegradable Plastics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020724:Elastomers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D008422:Materials Testing; D051379:Mice; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D063566:Biodegradable Plastics; D020724:Elastomers; D011140:Polyurethanes
keywords: biodegradable; conductivity; elasticity; electrical stability; polyurethane