title: Syndrome of Inappropriate Antidiuretic Hormone Associated with Eosinophilic Granulomatosis with Polyangiitis.
abstract: A 78-year-old woman with a history of bronchial asthma presented with distal dominant sensory disturbance and weakness in the upper and lower extremities. A biopsy of the left peroneus brevis muscle showed active vasculitis with inflammation extending into muscle fascicles and fibrinoid necrosis of the vessel wall, consistent with eosinophilic granulomatosis with polyangiitis (EGPA). Despite her decreased serum osmolarity, her serum antidiuretic hormone level was not reduced, consistent with the syndrome of inappropriate antidiuretic hormone (SIADH). Intravenous and oral steroid therapy improved her neurological symptoms. Clinicians should consider EGPA as a concurrent, and potentially causative, disorder in cases of SIADH.
authors.affiliation: Department of Neurology, Tokyo Teishin Hospital, Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Tokushige
authors.forename: Kako
authors.initials: K
authors.lastname: Kodama
authors.forename: Takuto
authors.initials: T
authors.lastname: Hideyama
authors.forename: Hanae
authors.initials: H
authors.lastname: Kumekawa
authors.forename: Jun
authors.initials: J
authors.lastname: Shimizu
authors.forename: Risa
authors.initials: R
authors.lastname: Maekawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiio
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D014667:Vasopressins
chemical_list: D000305:Adrenal Cortex Hormones; D014667:Vasopressins