title: Thyroid metastasis of bladder transitional cell carcinoma.
abstract: The thyroid gland is a rare site for cancer metastasis. We report a 75-year-old man who was referred with a history of hematuria and generalized bone pain for the past few months. He had a past history of partial left lobe thyroidectomy for follicular adenoma. Subsequently he was referred for a thyroid mass and a subtotal thyroidectomy showed a poorly-differentiated carcinoma. On the latest admission, the patient underwent resection of a bladder tumour with malignant histology and an immunohistochemical profile of CK7+/CK20+/34 Beta E12+/CEA-/PSA-. Re-examination of thyroid sections with immunohistochemical stains revealed the malignant cells to be CK7+/CK20+/34 Beta E12+/CEA-/TTF1-. The findings were compatible with metastasis of the bladder transitional cell carcinoma to the thyroid gland.Scans revealed multiple liver and bone metastases. The patient died 2 months after the diagnosis.
authors.affiliation: Buali hospital, Buali St., Qazvin, Iran, 3413786165. am.kazemifar@yahoo.com.
authors.forename: S M M
authors.initials: SM
authors.lastname: Mirjalili
authors.forename: S
authors.initials: S
authors.lastname: Hashemipour
authors.forename: S
authors.initials: S
authors.lastname: Salehi
authors.forename: A M
authors.initials: AM
authors.lastname: Kazemifar
authors.forename: P S
authors.initials: PS
authors.lastname: Madani
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001859:Bone Neoplasms / Q000556:secondary; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D015653:Cystectomy; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D013964:Thyroid Neoplasms / Q000556:secondary*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D051598:Whole Body Imaging
chemical_list: D014408:Biomarkers, Tumor