title: Nanoparticle transport across the blood brain barrier.
abstract: While the role of the blood-brain barrier (BBB) is increasingly recognized in the (development of treatments targeting neurodegenerative disorders, to date, few strategies exist that enable drug delivery of non-BBB crossing molecules directly to their site of action, the brain. However, the recent advent of Nanomedicines may provide a potent tool to implement CNS targeted delivery of active compounds. Approaches for BBB crossing are deeply investigated in relation to the pathology: among the main important diseases of the CNS, this review focuses on the application of nanomedicines to neurodegenerative disorders (Alzheimer, Parkinson and Huntington's Disease) and to other brain pathologies as epilepsy, infectious diseases, multiple sclerosis, lysosomal storage disorders, strokes.
authors.affiliation: WG Molecular Analysis of Synaptopathies, Neurology Dept, Neurocenter of Ulm University , Ulm, Germany.
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Grabrucker
authors.affiliation: Pharmaceutical Technology, Te.Far.T.I. Group, Department of Life Sciences, University of Modena and Reggio Emilia ; Modena, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ruozi
authors.affiliation: Pharmaceutical Technology, Te.Far.T.I. Group, Department of Life Sciences, University of Modena and Reggio Emilia ; Modena, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Belletti
authors.affiliation: Pharmaceutical Technology, Te.Far.T.I. Group, Department of Life Sciences, University of Modena and Reggio Emilia ; Modena, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pederzoli
authors.affiliation: Pharmaceutical Technology, Te.Far.T.I. Group, Department of Life Sciences, University of Modena and Reggio Emilia ; Modena, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Forni
authors.affiliation: Pharmaceutical Technology, Te.Far.T.I. Group, Department of Life Sciences, University of Modena and Reggio Emilia ; Modena, Italy.
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Vandelli
authors.affiliation: Pharmaceutical Technology, Te.Far.T.I. Group, Department of Life Sciences, University of Modena and Reggio Emilia ; Modena, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tosi
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism*; D002199:Capillary Permeability; D002493:Central Nervous System Diseases / Q000188:drug therapy; D004337:Drug Carriers / Q000493:pharmacokinetics; D006801:Humans; D053758:Nanoparticles / Q000378:metabolism*
chemical_list: D004337:Drug Carriers
keywords: BBB; drug delivery; drug targeting; liposome; nanocarrier; nanoparticle