title: Blockade of RAS-Binding Domain Interactions Inhibits RAS Signaling.
abstract: Rigosertib acts as a RAS mimetic, binding to the RAS-binding domain of multiple RAS effector proteins.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D018716:Molecular Mimicry; D009154:Mutation; D011485:Protein Binding / Q000187:drug effects; D054730:Protein Interaction Domains and Motifs; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D013450:Sulfones / Q000494:pharmacology; D018631:ras Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D013450:Sulfones; C507134:ON 01910; D018631:ras Proteins; D005998:Glycine