title: The effect of lead exposure on expression of SIRT1 in the rat hippocampus.
abstract: Based on how the silent information regulator 2 homolog 1 (SIRT1) regulates the cyclic AMP response element binding protein (CREB), which is the molecular switch of long-term memory that maintains cognitive function, it is postulated that the impact of lead (Pb) on SIRT1 is one of the mechanisms leading to Pb-induced cognitive and learning deficits. Hence, the purpose of this study was to investigate the effect of Pb exposure on the expression of SIRT1, and the reversion effect of resveratrol, which is an activator of SIRT1. We examined the effects of maternal rat ingestion of Pb in drinking water during gestation and lactation on the expression of SIRT1 and CREB in the hippocampus of their offspring at postnatal week 3 (PNW3) and 52 (PNW52), and then reexamined these effects in offspring after intragastric administration of resveratrol for 4 weeks. Pb exposure decreased SIRT1 and CREB phosphorylation in a dose-dependent manner in the rat hippocampus at both PNW3 and 52, and resveratrol reversed those losses. These results indicated that SIRT1 might be a novel target to prevent Pb neurotoxicity.
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Chang
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Junwang
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China.
authors.forename: Fankun
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Jiaoyang
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Anatomy, School of Medicine, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Gaochun
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Linfu
authors.initials: L
authors.lastname: Guan
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Haizhen
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Du
authors.affiliation: Department of Medical Experiment Teaching, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Jiangao
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China. Electronic address: fanguangqin@ncu.edu.cn.
authors.forename: Guangqin
authors.initials: G
authors.lastname: Fan
mesh_terms: D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007854:Lead / Q000633:toxicity*; D008297:Male; D008431:Maternal-Fetal Exchange; D018696:Neuroprotective Agents / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced; D012333:RNA, Messenger / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D018696:Neuroprotective Agents; D012333:RNA, Messenger; D013267:Stilbenes; D007854:Lead; C488368:Sirt1 protein, rat; D056564:Sirtuin 1; D000077185:Resveratrol
keywords: Lead; Rat hippocampus; Resveratrol; Silent information regulator 2 homolog 1; cAMP-response element binding protein