title: Adherence with urate-lowering therapies among male patients with gout in a routine clinical setting.
abstract: OBJECTIVE
  To assess adherence (compliance and persistence) and factors that might contribute to nonadherence to urate-lowering therapies (ULT) in patients with gout in a routine clinical setting.
  
  
  METHODS
  This prospective observational cohort study was conducted in the rheumatology center of a local tertiary hospital. A total of 132 male adults aged 75 years or younger who were incidentally diagnosed with gout were included. Adherence to ULT was assessed by the clinic nurses through pill counts.
  
  
  RESULTS
  Of the 132 patients, 94 (71.2%) was compliant and 81 (61.4%) was persistent with ULT. The logistic regression analysis revealed that the absence of chronic kidney disease (CKD) and the previous history of non-persistence with ULT are the independent factors associated with noncompliance and the absence of CKD is an independent factor associated with non-persistence. The average serum urate levels of the noncompliant (p = 0.001) and non-persistent (p = 0.002) patients were significantly higher than those of the compliant and persistent patients.
  
  
  CONCLUSIONS
  The absence of CKD and the previous history of non-persistence of ULT that are correlated with poor adherence and easily assessed can be used to identify patients at a particular risk of poor adherence.
authors.affiliation: a Division of Rheumatology, Department of Internal Medicine , Haeundae Paik Hospital, Inje University College of Medicine , Busan , Korea and.
authors.forename: Sunggun
authors.initials: S
authors.lastname: Lee
authors.affiliation: b Division of Rheumatology, Department of Internal Medicine , Pusan National University Yangsan Hospital , Gyeongnam, Korea.
authors.forename: Min Wook
authors.initials: MW
authors.lastname: So
mesh_terms: D000328:Adult; D000368:Aged; D006073:Gout / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D006074:Gout Suppressants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology
chemical_list: D006074:Gout Suppressants
keywords: Adherence; Compliance; Gout; Persistence