title: Effects of Anti-CD45RB Monoclonal Antibody for T Lymphocyte Subsets in Mice Heart Transplantation Model.
abstract: Anti-CD45RB monoclonal antibody (anti-CD45RBmAb), as a new immune tolerance inducer, may inhibit T cell proliferation and induce immune tolerance through competitive combination with CD45RB on the T cell surface, which blocks the conduction of activation signals. However, how anti-CD45RBmAb plays its role on T lymphocyte subsets during immunosuppression remains unclear. In this work, we investigate the effects of anti-CD45RBmAb on CD3(+) T lymphocyte both in vitro and in allogeneic heart transplant model in vivo. Interestingly, anti-CD45RBmAb could inhibit the proliferation of T cells, promote the transformation of T lymphocyte to Treg and Th2 cells, suppress the transformation to Th17 and Th1 cells, increase the number of Ts cells, decrease the number of Tm cells and thus play a role in immune inhibition and induction of immune tolerance.
authors.affiliation: The Key Laboratory of stem cell and Cellular therapy, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Deng
authors.affiliation: The Key Laboratory of stem cell and Cellular therapy, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China.
authors.forename: X-F
authors.initials: XF
authors.lastname: Wang
authors.affiliation: The Key Laboratory of stem cell and Cellular therapy, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China.
authors.forename: H
authors.initials: H
authors.lastname: Qi
authors.affiliation: The Key Laboratory of stem cell and Cellular therapy, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China.
authors.forename: F-R
authors.initials: FR
authors.lastname: Li
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D017493:Leukocyte Common Antigens / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D017493:Leukocyte Common Antigens