title: Angelica archangelia Prevented Collagen Degradation by Blocking Production of Matrix Metalloproteinases in UVB-exposed Dermal Fibroblasts.
abstract: Angelica archangelia (AA), a traditional herb, has attracted attention as an agent with potential for use in the prevention of chronic skin diseases. This study examined the photoprotective effects of AA on the inhibition of matrix metalloproteinases (MMPs) and collagen degradation in UVB-irradiated normal human dermal fibroblasts. Our results showed that AA markedly blocked collagen degradation by restraining the production of MMPs in UVB-exposed fibroblasts. We also investigated the underlying mechanism behind the effects of AA. AA attenuated UVB-triggered interleukin-6 (IL-6) and promoted the expression of transforming growth factor β1. Application of AA extract (10, 100 μg mL(-1) ) significantly diminished UVB-induced extracellular signal-regulated kinase and Jun-N-terminal kinase phosphorylation, which consequently reduced phosphorylated c-Fos and c-Jun. Our results indicated that AA inhibited the UVB-induced expression of MMPs by inhibiting mitogen-activated protein kinase signaling pathways and activator protein-1 activation. Our results suggest that AA is a promising botanical agent for use against skin photoaging.
authors.affiliation: Department of Oriental Medicinal Biotechnology, College of Life Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.
authors.forename: Zhengwang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: SD Biotechnologies Co., Ltd., Seoul, Korea.
authors.forename: Eunson
authors.initials: E
authors.lastname: Hwang
authors.affiliation: SD Biotechnologies Co., Ltd., Seoul, Korea.
authors.forename: Sang Yong
authors.initials: SY
authors.lastname: Park
authors.affiliation: Department of Oriental Medicinal Biotechnology, College of Life Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.
authors.forename: Mengyang
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Oriental Medicinal Biotechnology, College of Life Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Oriental Medicinal Biotechnology, College of Life Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.
authors.forename: Pei
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Oriental Medicinal Biotechnology, College of Life Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.
authors.forename: Tae-Hoo
authors.initials: TH
authors.lastname: Yi
mesh_terms: D029970:Angelica archangelica / Q000378:metabolism*; D003094:Collagen / Q000737:chemistry*; D024042:Collagen Type I / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects* / Q000528:radiation effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species; D015398:Signal Transduction; D012867:Skin / Q000166:cytology; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D024042:Collagen Type I; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D003094:Collagen; D020781:Matrix Metalloproteinase 1