title: Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients.
abstract: Saphenous venous grafts (SVGs) are established choices for coronary artery bypass grafting (CABG); however, their lumen patency is limited. Our goal was to investigate the risk factors of SVG degeneration.
  
  
  
  Seventy-five patients (mean age, 57.5±10.4 years) with 133 SVG conduits who had cardiac catheterization ≥1 year after CABG were selected; follow-up period was 67.6±36.8 months. Patients were divided into 3 groups according to angiographic status at follow up [intact: <20% (n=23); narrowed: 20-99% (n=24); and occluded (n=28)]. Baseline clinical conditions were evaluated in relation to follow-up angiography. As onset date of chronic total occlusions is usually uncertain, they arise typically from thrombotic lesions; thus, their value in evaluation is limited.
  
  
  
  There were no significant differences between the 3 groups in clinical parameters. Linear correlation analysis found significant (p<0.01) positive connection of SVG disease (luminal diameter reduction 20-99%) with C-reactive protein (CRP) and homocysteine (Hcy), as well as between CRP and Hcy. Multiple regression analysis showed plasma Hcy level to be significantly related to graft diameter reduction normalized to time elapsed until angiography in narrowed grafts: 1 µmol/L increase of Hcy was associated with 0.053%/month decrease in lumen diameter (p<0.01; R2=0.428); extrapolating: +10 µmol/L higher Hcy level during 5 years is associated with 32.1% lumen reduction.
  
  
  
  Medium- to long-term SVG degeneration is related to elevated plasma total Hcy in patients with sub-occlusive graft stenosis, while in cases with intact SVGs, the beneficial local flow conditions may protect the grafts from degeneration.
authors.affiliation: Department of Cardiology, Institute of Cardiology, Faculty of Medicine, University of Debrecen, Hungary. baloghemiliadr@gmail.com.
authors.forename: Emília
authors.initials: E
authors.lastname: Balogh
authors.affiliation: epartment of Cardiac Surgery, Institute of Cardiology, Faculty of Medicine, University of Debrecen, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Maros
authors.affiliation: Department of Cardiology, Institute of Cardiology, Faculty of Medicine, University of Debrecen, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Daragó
authors.affiliation: Department of Cardiology, Borsod County Hospital, Miskolc-Hungary.
authors.forename: Kálmán
authors.initials: K
authors.lastname: Csapó
authors.affiliation: Department of Cardiology, Géza Hetényi County Hospital and Outpatient Centre, Szolnok-Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Herceg
authors.affiliation: Faculty of Informatics University of Debrecen, Debrecen-Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Nyul
authors.affiliation: Department of Cardiology, Institute of Cardiology, Faculty of Medicine, University of Debrecen, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Czuriga
authors.affiliation: Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Bereczky
authors.affiliation: Department of Cardiology, Institute of Cardiology, Faculty of Medicine, University of Debrecen, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Édes
authors.affiliation: Department of Cardiology, Institute of Cardiology, Faculty of Medicine, University of Debrecen, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Koszegi
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D012501:Saphenous Vein; D016896:Treatment Outcome; D014654:Vascular Patency
chemical_list: D006710:Homocysteine