title: [The clinical and imaging features of 118 patients with spontaneous cerebral arterial dissections presenting with ischemic stroke].
abstract: OBJECTIVE
  To investigate the clinical and radiologic features of patients with spontaneous cerebral arterial dissections (CADs) presenting with ischemic stroke and to explore the effect of gender and age on those features.
  
  
  METHODS
  Patients admitted to our stroke center diagnosed as ischemic stroke secondary to CADs from August 2008 to April 2015 were prospectively registered. Patients aged between 15 to 80 years old, who had acute brain infarcts within the territory of a major cerebral artery affected by a dissection confirmed by the neuroradiological examinations, were enrolled in the study. The followings were the exclusion criteria: (1) there were any potential causes for the brain infarcts other than CADs; (2) CADs were the results of a definite cause; (3) the clinical data were incomplete.
  
  
  RESULTS
  A total of 118 patients were enrolled in the study with the mean age of (44.2±12.8) years old. There were 87 men (73.7%) and 67 patients (56.8%) aged under 45 years old. Smoking (41.5%), hypertension (25.4%) and hypercholesterolemia (21.2%) were the three leading risk factors for stroke. Hypercholesterolemia was more common in the male patients (25.3% vs 9.7%, P=0.021), whereas hypertension (39.2% vs 14.9%, P=0.005) and diabetes (25.5% vs 4.5%, P=0.002) were more common in the patients aged 45 years or older. Headache or neck pain before or at the onset of stroke was more common in the female patients (67.7% vs 34.5%, P=0.002). A total of 71 patients were found with CADs of the anterior circulation, while 47 patients with that of the posterior circulation. The involvement of the intra and extracranial arteries were documented in 59 and 59 patients, respectively. The middle cerebral artery (MCA) was the most common site in the intracranial dissection and more MCA dissections were observed in the male patients (46.3% vs 11.1%, P=0.016). The dissection of intracranial carotid artery was more common in patients aged under 45 years old (38.7% vs 0, P<0.001). Lumen status of CADs often presented as stenosis (43.2%) and occlusion (41.2%), while less aneurysm (5.9%) and aneurysm with stenosis (9.3%) were observed. Aneurysm was found to be more common in patients aged 45 years or older (11.8% vs 1.5%, P=0.042).
  
  
  CONCLUSIONS
  Chinese patients with spontaneous CADs presenting with ischemic stroke have unique clinical and imaging features, which correlated with age and gender.
authors.forename: H B
authors.initials: HB
authors.lastname: Chen
authors.forename: Z H
authors.initials: ZH
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Hong
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: A W
authors.initials: AW
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: B N
authors.initials: BN
authors.lastname: Luo
authors.affiliation: Department of Neurology and Stroke Center, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000150:complications / Q000473:pathology*; D044466:Asian People; D001921:Brain; D002536:Cerebral Arteries / Q000473:pathology*; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology*; D002681:China; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia; D006973:Hypertension; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking; D020521:Stroke / Q000150:complications* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy