title: Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life.
abstract: To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal T cell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been implicated in passive immunity to pathogens while the latter mediates host-commensal mutualism. Here, we report the surprising observation that mice generate T cell-independent and largely Toll-like receptor (TLR)-dependent IgG2b and IgG3 antibody responses against their gut microbiota. We demonstrate that maternal acquisition of these antibodies dampens mucosal T follicular helper responses and subsequent germinal center B cell responses following birth. This work reveals a feedback loop whereby T cell-independent, TLR-dependent antibodies limit mucosal adaptive immune responses to newly acquired commensal antigens and uncovers a broader function for maternal IgG.
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: Meghan A
authors.initials: MA
authors.lastname: Koch
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: Gabrielle L
authors.initials: GL
authors.lastname: Reiner
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: Kyler A
authors.initials: KA
authors.lastname: Lugo
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: Lieselotte S M
authors.initials: LS
authors.lastname: Kreuk
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: Alison G
authors.initials: AG
authors.lastname: Stanbery
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: Eduard
authors.initials: E
authors.lastname: Ansaldo
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: Thaddeus D
authors.initials: TD
authors.lastname: Seher
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
authors.forename: William B
authors.initials: WB
authors.lastname: Ludington
authors.affiliation: Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA. Electronic address: barton@berkeley.edu.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Barton
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology* / Q000382:microbiology; D001402:B-Lymphocytes / Q000276:immunology; D000069196:Gastrointestinal Microbiome; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008895:Milk, Human / Q000276:immunology*; D015398:Signal Transduction; D013047:Specific Pathogen-Free Organisms; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D051193:Toll-Like Receptors