title: PREDAC-H3: a user-friendly platform for antigenic surveillance of human influenza a(H3N2) virus based on hemagglutinin sequences.
abstract: Timely surveillance of the antigenic dynamics of the influenza virus is critical for accurate selection of vaccine strains, which is important for effective prevention of viral spread and infection.
  
  
  
  Here, we provide a computational platform, called PREDAC-H3, for antigenic surveillance of human influenza A(H3N2) virus based on the sequence of surface protein hemagglutinin (HA). PREDAC-H3 not only determines the antigenic variants and antigenic cluster (grouped for similar antigenicity) to which the virus belongs, based on HA sequences, but also allows visualization of the spatial distribution and temporal dynamics of antigenic clusters of viruses isolated from around the world, thus assisting in antigenic surveillance of human influenza A(H3N2) virus.
  
  
  
  It is publicly available from: http://biocloud.hnu.edu.cn/influ411/html/index.php
  
  
  
  : yshu@cnic.org.cn or taijiao@moon.ibp.ac.cn.
authors.affiliation: College of Biology, Hunan University, Changsha, China College of Computer Science and Electronic Engineering, Hunan University, Changsha, China.
authors.forename: Yousong
authors.initials: Y
authors.lastname: Peng
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: College of Computer Science and Electronic Engineering, Hunan University, Changsha, China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Computer Science and Electronic Engineering, Hunan University, Changsha, China.
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Center of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.
authors.forename: Lizong
authors.initials: L
authors.lastname: Deng
authors.affiliation: Center of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Wu
authors.affiliation: Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Du
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
authors.forename: Dayan
authors.initials: D
authors.lastname: Wang
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Shu
authors.affiliation: College of Biology, Hunan University, Changsha, China Center of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.
authors.forename: Taijiao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000940:Antigenic Variation; D000956:Antigens, Viral; D019295:Computational Biology / Q000379:methods*; D004279:DNA, Viral; D062665:Epidemiological Monitoring; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006388:Hemagglutinins; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus; D007251:Influenza, Human / Q000453:epidemiology*; D017422:Sequence Analysis, DNA
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006388:Hemagglutinins