title: Serum miR-1297: a promising diagnostic biomarker in esophageal squamous cell carcinoma.
abstract: We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected in 156 pairs of patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It was statistically decreased in ESCC patients compared with healthy controls. AUC based on serum miR-1297 was 0.840 ± 0.035 in discovery group and 0.837 ± 0.034 in validation group. Further analysis on early-stage patients revealed that the AUC was 0.819 ± 0.053 in discovery group and 0.814 ± 0.044 in validation group. Its sensitivity and specificity were promising. In conclusion, serum miR-1297 can serve as an ideal indicator for the diagnosis of ESCC.
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.affiliation: b Department of Cardiac Surgery , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Qingbao
authors.initials: Q
authors.lastname: Li
authors.affiliation: c Department of Imaging , Shandong Medical College , Jinan , Shandong , People's Republic of China ;
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Xuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Effat Un
authors.initials: EU
authors.lastname: Nesa
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Shanghui
authors.initials: S
authors.lastname: Guan
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Bowen
authors.initials: B
authors.lastname: Liu
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Lihui
authors.initials: L
authors.lastname: Han
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Bingxu
authors.initials: B
authors.lastname: Tan
authors.affiliation: d Department of Clinical Laboratory , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China.
authors.forename: Ding
authors.initials: D
authors.lastname: Wang
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Pengxiang
authors.initials: P
authors.lastname: Chen
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Xiaoyue
authors.initials: X
authors.lastname: Liu
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.affiliation: a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; C578622:MIRN1297 microRNA, human; D035683:MicroRNAs
keywords: Biomarker; diagnosis; esophageal cancer; miR-1297; qRT-PCR,