title: Prostate cancer with a pseudocapsule at MR imaging: a marker of high grade and stage disease?
abstract: Clinicopathological correlates of prostate cancer associated with a pseudocapsule at T2-weighted magnetic resonance (MR) imaging are presented in a retrospective series of 15 patients. Of 15 tumors, 14 involved the peripheral zone. Extracapsular extension was seen in 14 cases. Tumor Gleason score was 8 or above in 12 of 15 cases, and ductal type adenocarcinoma was identified in 4 cases. Step section histopathological correlation (n=5) demonstrated that the pseudocapsule corresponded with dense compressive or reactive peritumoral fibrosis. A pseudocapsule around prostate cancer at T2-weighted MR imaging is a rare finding that appears to be associated with high grade and stage disease.
authors.affiliation: Department of Diagnostic, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code: L340, Portland, OR 97239.
authors.forename: Apurva A
authors.initials: AA
authors.lastname: Bonde
authors.affiliation: Department of Diagnostic, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code: L340, Portland, OR 97239.
authors.forename: Elena K
authors.initials: EK
authors.lastname: Korngold
authors.affiliation: Department of Diagnostic, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code: L340, Portland, OR 97239.
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Foster
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628.
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Westphalen
authors.affiliation: Department of Diagnostic, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code: L340, Portland, OR 97239.
authors.forename: David R
authors.initials: DR
authors.lastname: Pettersson
authors.affiliation: Department of Pathology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code: L340, Portland, OR 97239.
authors.forename: Megan L
authors.initials: ML
authors.lastname: Troxell
authors.affiliation: Department of Anatomic Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628.
authors.forename: Jeffry P
authors.initials: JP
authors.lastname: Simko
authors.affiliation: Department of Diagnostic, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code: L340, Portland, OR 97239. Electronic address: coakleyf@ohsu.edu.
authors.forename: Fergus V
authors.initials: FV
authors.lastname: Coakley
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies
keywords: MR imaging; Pathology; Prostate cancer; Pseudocapsule