title: Oxidative Stress in Children with Chronic Spontaneous Urticaria.
abstract: The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements. The median value of plasma TOS was found to be 10.49 μmol H2O2 equiv./L (interquartile range, 7.29-17.65) in CSU patients and 7.68 μmol H2O2 equiv./L (5.95-10.39) in the control group. The difference between the groups was statistically significant (p = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30-2.74] versus 2.76 [2.65-2.86] mmol Trolox equiv./L, resp., p = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity.
authors.affiliation: Department of Pediatric Allergy and Immunology, Bezmialem Vakif University Medical Faculty, Adnan Menderes Bulvari, Vatan Caddesi, Fatih, 34093 Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Dilek
authors.affiliation: Department of Pediatric Allergy and Immunology, Istanbul University Istanbul Medical Faculty, Fatih, Capa, 34093 Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Ozceker
authors.affiliation: Department of Pediatric Allergy and Immunology, Bezmialem Vakif University Medical Faculty, Adnan Menderes Bulvari, Vatan Caddesi, Fatih, 34093 Istanbul, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Ozkaya
authors.affiliation: Department of Pediatrics, Istanbul Bilim University, Buyukdere Caddesi No. 120, Esentepe, Sisli, 34394 Istanbul, Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Guler
authors.affiliation: Department of Pediatric Allergy and Immunology, Istanbul University Istanbul Medical Faculty, Fatih, Capa, 34093 Istanbul, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Tamay
authors.affiliation: Department of Clinical Biochemistry, Bezmialem Vakif University Medical Faculty, Adnan Menderes Bulvari, Vatan Caddesi, Fatih, 34093 Istanbul, Turkey.
authors.forename: Siddika
authors.initials: S
authors.lastname: Kesgin
authors.affiliation: Department of Pediatric Allergy and Immunology, Bezmialem Vakif University Medical Faculty, Adnan Menderes Bulvari, Vatan Caddesi, Fatih, 34093 Istanbul, Turkey.
authors.forename: Mebrure
authors.initials: M
authors.lastname: Yazici
authors.affiliation: Department of Clinical Biochemistry, Bezmialem Vakif University Medical Faculty, Adnan Menderes Bulvari, Vatan Caddesi, Fatih, 34093 Istanbul, Turkey.
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Kocyigit
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D003710:Demography; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008297:Male; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D014581:Urticaria / Q000378:metabolism / Q000473:pathology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide