title: Global and regional lung function in cystic fibrosis measured by electrical impedance tomography.
abstract: Electrical impedance tomography (EIT) delivers information about global and regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the feasibility of EIT during lung function tests in pediatric patients with cystic fibrosis (CF) and healthy controls.
  
  
  
  Eleven CF patients and 11 age-matched controls underwent spirometry and simultaneous EIT. Global EIT results were scaled to spirometric forced vital capacity (FVC). Subsequently, global and regional "EIT-spirometry" was calculated and correlated with clinical findings, radiology, and lung function results before and after bronchospasmolysis (BSL).
  
  
  
  Spirometry and global EIT results correlated essentially (r2= 0.71-1.0, P < 0.001). While lung function results were comparable for both groups, EIT demonstrated inhomogeneous ventilation and individual changes after BSL.
  
  
  
  EIT changes during forced expiration correlate with lung function parameters, clinical findings, and radiology. Regional analysis of EIT illustrates regional lung function and visualizes individual therapeutic effects. Pediatr Pulmonol. 2016;51:1191-1199. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Division of Pediatric Pulmonology, Department of Pediatrics, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. slehmann@ukaachen.de.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Lehmann
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen, Aachen, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Leonhardt
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen, Aachen, Germany.
authors.forename: Chuong
authors.initials: C
authors.lastname: Ngo
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen, Aachen, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Bergmann
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen, Aachen, Germany.
authors.forename: Ines
authors.initials: I
authors.lastname: Ayed
authors.affiliation: Department of Radiology, University Hospital RWTH Aachen, Aachen, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Schrading
authors.affiliation: Division of Pediatric Pulmonology, Department of Pediatrics, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Tenbrock
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000503:physiopathology*; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D012119:Respiration; D012129:Respiratory Function Tests / Q000379:methods; D013147:Spirometry / Q000379:methods*; D013990:Tidal Volume; D014054:Tomography / Q000379:methods*
keywords: Tiffeneau maneuver; cystic fibrosis; electrical impedance tomography; lung function test; radiology; regional lung function