title: Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides.
abstract: Polysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand-receptor interactions with biochemical processes and in vivo studies that focus on the potential therapeutic impact of polySia, polySia glycomimetics, and sulfated polysaccharides in neuronal diseases. With this strategy, the receptor interactions of polySia and polySia mimetics can be understood on a submolecular level. As the HNK-1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo- and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases. The knowledge obtained here on the structural interplay between polySia or sulfated polysaccharides and their receptors can be exploited to develop new drugs and application routes for the treatment of neurological diseases and dysfunctions.
authors.affiliation: RI-B-NT: Research Institute of Bioinformatics and Nanotechnology, Franziusallee 177, 24148, Kiel, Germany.|Zoological Institute, Department of Structural Biology, Kiel University, Am Botanischen Garten 1-9, 24118, Kiel, Germany.
authors.forename: Ruiyan
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, University of Hamburg, Falkenried 94, 20251, Hamburg, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Loers
authors.affiliation: Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, University of Hamburg, Falkenried 94, 20251, Hamburg, Germany.|Center for Neuroscience, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong, 515041, China.
authors.forename: Melitta
authors.initials: M
authors.lastname: Schachner
authors.affiliation: Bijvoet Center for Biomolecular Research, NMR Spectroscopy, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
authors.forename: Rolf
authors.initials: R
authors.lastname: Boelens
authors.affiliation: Bijvoet Center for Biomolecular Research, NMR Spectroscopy, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: Wienk
authors.affiliation: RI-B-NT: Research Institute of Bioinformatics and Nanotechnology, Franziusallee 177, 24148, Kiel, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Siebert
authors.affiliation: Institute of Veterinary Physiology and Biochemistry, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen, Frankfurter Str. 100, 35392, Gießen, Germany.|Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-Universität Gießen, Frankfurter Str. 106, 35392, Gießen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Eckert
authors.affiliation: Ocean Harvest Technology Ltd., N17 Business Park, Milltown, County Galway, Ireland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kraan
authors.affiliation: Institute of Veterinary Physiology and Biochemistry, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen, Frankfurter Str. 100, 35392, Gießen, Germany.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Rojas-Macias
authors.affiliation: Institute of Veterinary Physiology and Biochemistry, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen, Frankfurter Str. 100, 35392, Gießen, Germany.
authors.forename: Thomas
authors.identifier: http://orcid.org/0000-0002-7140-9933
authors.initials: T
authors.lastname: Lütteke
authors.affiliation: Institute of Biochemistry, Faculty of Medicine, Justus-Liebig-Universität Gießen, Friedrichstr. 24, 35392, Gießen, Germany.
authors.forename: Sebastian P
authors.initials: SP
authors.lastname: Galuska
authors.affiliation: Zoological Institute, Department of Structural Biology, Kiel University, Am Botanischen Garten 1-9, 24118, Kiel, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Scheidig
authors.affiliation: Neurosurgery Clinic, University Düsseldorf, Moorenstraße 5, 40255, Düsseldorf, Germany.
authors.forename: Athanasios K
authors.initials: AK
authors.lastname: Petridis
authors.affiliation: College of Life Sciences, Hunan Normal University, 410081, Changsha, China.
authors.forename: Songping
authors.initials: S
authors.lastname: Liang
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Box 100, 40530, Gothenburg, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Billeter
authors.affiliation: Institute of Biochemistry, Kiel University, Olshausenstr. 40, 24098, Kiel, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Schauer
authors.affiliation: Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University Hospital Giessen and Marburg GmbH, Paul-Meimberg-Str. 3, 35392, Gießen, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Steinmeyer
authors.affiliation: Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany.
authors.forename: Jens-Michael
authors.initials: JM
authors.lastname: Schröder
authors.affiliation: RI-B-NT: Research Institute of Bioinformatics and Nanotechnology, Franziusallee 177, 24148, Kiel, Germany. hcsiebert@aol.com.
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Siebert
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002454:Cell Differentiation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018613:Microscopy, Confocal; D062105:Molecular Docking Simulation; D008969:Molecular Sequence Data; D000076250:Myristoylated Alanine-Rich C Kinase Substrate; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012794:Sialic Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011134:Polysaccharides; D012794:Sialic Acids; C021319:polysialic acid; D000076250:Myristoylated Alanine-Rich C Kinase Substrate
keywords: molecular interactions; polysia mimetics; polysialic acid; sulfated polysaccharides