title: Regioselective synthesis of 3,4-disubstituted isocoumarins through the Pd-catalyzed annulation of 2-iodoaromatic acids with ynamides.
abstract: A Pd(0)-catalyzed annulation reaction of ynamides is described for the efficient synthesis of 3,4-disubstituted isocoumarins. This novel methodology allows for the concomitant construction of O-C and C-C bonds between 2-iodoaromatic acids and ynamides, exhibiting excellent regioselectivities and a wide functional group tolerance.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China.
authors.forename: Hongxu
authors.initials: H
authors.lastname: Liu
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Wang
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang