title: [Inhibitory Properties of Nitrogen-Containing Adamantane Derivatives with Monoterpenoid Fragments Against Tyrosyl-DNA Phosphodiesterase I].
abstract: It was found that compounds combining diazaadamantane and monoterpenoid fragments are potent inhibitors of new structural type of human recombinant DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1). It was demonstrated that the inhibition efficiency depended on the length and flexibility of the aliphatic chain of the substituent.
authors.forename: A L
authors.initials: AL
authors.lastname: Zakharenko
authors.forename: K U
authors.initials: KU
authors.lastname: Ponomarev
authors.forename: E V
authors.initials: EV
authors.lastname: Suslov
authors.forename: D V
authors.initials: DV
authors.lastname: Korchagina
authors.forename: K P
authors.initials: KP
authors.lastname: Volcho
authors.forename: I A
authors.initials: IA
authors.lastname: Vasil'eva
authors.forename: N F
authors.initials: NF
authors.lastname: Salakhutdinov
authors.forename: O I
authors.initials: OI
authors.lastname: Lavrik
mesh_terms: D000218:Adamantane / Q000138:chemical synthesis / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D039821:Monoterpenes / Q000138:chemical synthesis / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D039821:Monoterpenes; D010727:Phosphoric Diester Hydrolases; C498508:TDP1 protein, human; D009584:Nitrogen; D000218:Adamantane