title: Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study.
abstract: OBJECTIVE
  The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR study.
  
  
  METHODS
  PREDATORR was an epidemiological study with a stratified, cross-sectional, cluster random sampling design. Participants were classified into four cardiometabolic phenotypes based on the BMI, the cut-off value being 25 kg/m(2), and the presence of MetS (defined according to the Harmonization definition 2009): MUHL, MHO, metabolically healthy lean (MHL) and metabolically unhealthy overweight/obese (MUHO).
  
  
  RESULTS
  Overall, 2681 subjects aged 20-79 years were included in the analysis. The overall age and sex-adjusted prevalence of obesity was 31.90 %, overweight was 34.7 %, abdominal obesity was 73.90 % and MetS was 38.50 %. The age- and sex-adjusted prevalence of MHO phenotype was 31.60 %, while MUHL phenotype prevalence was 3.90 %. MUHL and MHO participants had a cardiometabolic profile, kidney function and CVD risk intermediary between MHL and MUHO. MUHL had higher odds of being associated with CVD risk (OR 5.8; p < 0.001), abdominal obesity, prediabetes, diabetes, hypertriglyceridemia and hypo-HDL cholesterolemia than MHL, while MHO phenotype was associated with hypo-HDL cholesterolemia (OR 3.1; p = 0.002), prediabetes (OR 2.9; p < 0.001) and abdominal obesity.
  
  
  CONCLUSIONS
  PREDATORR study showed a high prevalence of obesity/overweight, abdominal obesity and MetS in the adult Romanian population, and their association with kidney function and several cardiometabolic factors.
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania.
authors.forename: S
authors.initials: S
authors.lastname: Popa
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania. mmota53@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Moţa
authors.affiliation: Emergency Clinical Hospital Craiova, Craiova, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Popa
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania.
authors.forename: E
authors.initials: E
authors.lastname: Moţa
authors.affiliation: University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Serafinceanu
authors.affiliation: University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Guja
authors.affiliation: University "Ovidius"Constanţa, Constanţa, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Catrinoiu
authors.affiliation: University of Medicine and Pharmacy "Iuliu Haţieganu", Cluj-Napoca, Romania.
authors.forename: N
authors.initials: N
authors.lastname: Hâncu
authors.affiliation: University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: R
authors.initials: R
authors.lastname: Lichiardopol
authors.affiliation: University of Medicine and Pharmacy "Iuliu Haţieganu", Cluj-Napoca, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Bala
authors.affiliation: University Oradea, Oradea, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Popa
authors.affiliation: University of Medicine and Pharmacy "Iuliu Haţieganu", Cluj-Napoca, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Roman
authors.affiliation: University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Radulian
authors.affiliation: University of Medicine and Pharmacy "Victor Babeș", Timișoara, Romania.
authors.forename: R
authors.initials: R
authors.lastname: Timar
authors.affiliation: University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.
authors.forename: B
authors.initials: B
authors.lastname: Mihai
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D056128:Obesity, Abdominal / Q000150:complications / Q000453:epidemiology*; D050177:Overweight / Q000150:complications / Q000453:epidemiology*; D010641:Phenotype; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D055815:Young Adult
keywords: Metabolic syndrome; Metabolically healthy overweight/obesity phenotype; Metabolically unhealthy lean phenotype; Obesity/overweight; PREDATORR study; Romania