title: Mid-luteal phase injection of subcutaneous leuprolide acetate improves live delivered pregnancy and implantation rates in younger women undergoing in vitro fertilization-embryo transfer (IVF-ET).
abstract: OBJECTIVE
  To determine if a single injection of one-mg leuprolide acetate three days after embryo transfer (ET) in younger women causes an increase in pregnancy rates, and if so, is it associated with a higher initial serum hCG level?
  
  
  METHODS
  A prospective study was initiated where women aged ≤ 35 years were offered the option of taking the leuprolide or not.
  
  
  RESULTS
  Though a significant difference was not found, there was a trend for higher live delivered pregnancy rates in those taking the leuprolide supplement (47.8%) vs. those not taking it (38.6%). There was no difference in the first serum beta hCG level.
  
  
  CONCLUSIONS
  The trends is interesting enough to continue with a higher powered study.
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: C
authors.initials: C
authors.lastname: Wilson
authors.forename: J K
authors.initials: JK
authors.lastname: Choe
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D016729:Leuprolide / Q000627:therapeutic use*; D050498:Live Birth; D008183:Luteal Phase; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D016729:Leuprolide