title: Systematic Construction of Ternary Cocrystals by Orthogonal and Robust Hydrogen and Halogen Bonds.
abstract: A carefully designed strategy is presented for the construction of ternary cocrystals, based on the orthogonality of two supramolecular interaction modes: hydrogen bonding between crown ethers and thioureas and the halogen bonding between thioureas and perfluorohalocarbons. Tested on a set comprising two crown ethers, two thioureas and five halogen bond donors, the strategy resulted in a high, 75% success rate, with 15/20 component combinations yielding at least one cocrystal. Crystal structure analysis revealed the interplay between the hydrogen and halogen bonding motifs, also shedding light on the variables affecting their formation.
authors.affiliation: University of Jyvaskyla , Department of Chemistry, Nanoscience Center, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
authors.forename: Filip
authors.initials: F
authors.lastname: Topić
authors.affiliation: University of Jyvaskyla , Department of Chemistry, Nanoscience Center, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
authors.forename: Kari
authors.initials: K
authors.lastname: Rissanen