title: ASSESSMENT OF ADVERSE DRUG REACTIONS AS CARDIOVASCULAR RISK FACTORS.
abstract: A wide range of pharmaceutical substances can induce side-effects expressed as cardiovascular changes or events, adding to other risk factors or worsening preexisting cardiovascular diseases.
  
  
  OBJECTIVE
  Continuous study focused on iatrogenic conditions representing cardiovascular risk factors.
  
  
  METHODS
  We developed a descriptive study of patients admitted to the Iasi Vth Internal Medicine and Geriatrics-Gerontology Clinic between 1998-2013, focusing on iatrogenic conditions representing cardiovascular risk factors.
  
  
  RESULTS
  We have diagnosed 81 cases of drug-induced hypertension, and 43 patients with hypertensive crises; 72 cases of iatrogenic hyperglycemia; 36 cases of drug-induced hyperuricemia; 50 cases of drug-induced dyslipidemias; and 17 cases of iatrogenic obesity. These iatrogenic diseases were more common in women and the elderly. Twenty-eight patients have developed simultaneous adverse drug reactions induced by the same drug and manifest as different cardiovascular risk factors.
  
  
  CONCLUSIONS
  Cardiovascular risk factors can be induced to a significant extent by chronic drug administration. Some medications (e.g., NSAIDs, corticoids, beta-blockers, diuretics, contraceptives) can act on the same patient by multiple pathogenic links. The adverse drug reactions can be cardiovascular risk factors that persist in time, or can be removed (by discontinuing the administration of the implicated drug). The highest importance of their acknowledgment relies on the possibility of their prevention through carefully balancing the benefits and the risk of each new medication.
authors.forename: Cristina Maria
authors.initials: CM
authors.lastname: Gavrilescu
authors.forename: Maura G
authors.initials: MG
authors.lastname: Felea
authors.forename: Roxana
authors.initials: R
authors.lastname: Barbu
authors.forename: Odetta
authors.initials: O
authors.lastname: Duma
authors.forename: Maria Mădălina
authors.initials: MM
authors.lastname: Bodescu
authors.forename: Maria
authors.initials: M
authors.lastname: Midilina Bodescul
authors.forename: Rodica
authors.initials: R
authors.lastname: Ghiuru
authors.forename: C
authors.initials: C
authors.lastname: Boerescu
authors.forename: Crânguţa
authors.initials: C
authors.lastname: Paraschiv
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002317:Cardiovascular Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000139:chemically induced*; D004232:Diuretics / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D050171:Dyslipidemias / Q000139:chemically induced*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D033461:Hyperuricemia / Q000139:chemically induced*; D008297:Male; D009765:Obesity / Q000139:chemically induced*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012383:Romania; D013997:Time Factors
chemical_list: D002317:Cardiovascular Agents; D004232:Diuretics