title: The First Successful Heart-Lung Transplant in a Korean Child with Humidifier Disinfectant-Associated Interstitial Lung Disease.
abstract: From 2006 to 2011, an outbreak of a particular type of childhood interstitial lung disease occurred in Korea. The condition was intractable and progressed to severe respiratory failure, with a high mortality rate. Moreover, in several familial cases, the disease affected young women and children simultaneously. Epidemiologic, animal, and post-interventional studies identified the cause as inhalation of humidifier disinfectants. Here, we report a 4-year-old girl who suffered from severe progressive respiratory failure. She could survive by 100 days of extracorporeal membrane oxygenation support and finally, underwent heart-lung transplantation. This is the first successful pediatric heart-lung transplantation carried out in Korea.
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, College of Medicine, University of Ulsan, Seoul, Korea .
authors.forename: Won Kyoung
authors.identifier: 0000-0003-2309-0494
authors.initials: WK
authors.lastname: Jhang
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, College of Medicine, University of Ulsan, Seoul, Korea .
authors.forename: Seong Jong
authors.identifier: 0000-0003-0250-2381
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, College of Medicine, University of Ulsan, Seoul, Korea .
authors.forename: Eun
authors.identifier: 0000-0002-7462-0144
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, College of Medicine, University of Ulsan, Seoul, Korea .
authors.forename: Song I
authors.identifier: 0000-0002-9648-4585
authors.initials: SI
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, College of Medicine, University of Ulsan, Seoul, Korea .
authors.forename: Soo Jong
authors.identifier: 0000-0003-1409-2113
authors.initials: SJ
authors.lastname: Hong
authors.affiliation: Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea .
authors.forename: Ju-Hee
authors.identifier: 0000-0001-6783-2942
authors.initials: JH
authors.lastname: Seo
authors.affiliation: Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea .
authors.forename: Hyung-Young
authors.identifier: 0000-0001-8591-1783
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Jeong-Jun
authors.identifier: 0000-0003-0212-5475
authors.initials: JJ
authors.lastname: Park
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Tae-Jin
authors.identifier: 0000-0001-8441-4574
authors.initials: TJ
authors.lastname: Yun
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Hyeong Ryul
authors.identifier: 0000-0002-6691-7693
authors.initials: HR
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Yong-Hee
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Dong Kwan
authors.identifier: 0000-0003-1984-0352
authors.initials: DK
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Seung-Il
authors.identifier: 0000-0002-8729-0498
authors.initials: SI
authors.lastname: Park
authors.affiliation: Division of Infectious Disease, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Sang-Oh
authors.identifier: 0000-0003-1381-8787
authors.initials: SO
authors.lastname: Lee
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Sang-Bum
authors.initials: SB
authors.lastname: Hong
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: Tae-Sun
authors.identifier: 0000-0001-6653-816X
authors.initials: TS
authors.lastname: Shim
authors.affiliation: Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
authors.forename: In-Cheol
authors.identifier: 0000-0002-7386-5043
authors.initials: IC
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, College of Medicine, University of Ulsan, Seoul, Korea .
authors.forename: Jinho
authors.identifier: 0000-0002-1226-8077
authors.initials: J
authors.lastname: Yu
mesh_terms: D002675:Child, Preschool; D004202:Disinfectants / Q000633:toxicity; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D000068998:Humidifiers; D008168:Lung / Q000187:drug effects / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy*; D016040:Lung Transplantation; D056910:Republic of Korea; D056152:Respiratory Rate; D012189:Retrospective Studies; D013909:Thorax / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D004202:Disinfectants
keywords: Extracorporeal Membrane Oxygenation; Heart-Lung Transplantation; Inhalation Exposure; Interstitial Lung Disease