title: Type 2M and Type 2A von Willebrand Disease: Similar but Different.
abstract: Analogous to the differentiation between hemophilia A and B, respectively, reflecting deficiency in factor VIII (FVIII) and FIX, and increasing being recognized as reflecting clinically different disorders, types 2A and 2M von Willebrand disease (VWD) can also be shown to express both similarities and differences in their prevalence, genetic defects, laboratory test results, clinical features, and treatment responses. In this narrative review, we explore these two "subtypes" of type 2 VWD, identifying parallels and dissimilarities in various aspects of their presentation to clinicians and to scientists/laboratories. This differential will become increasingly important as we strive to provide personalized approaches to future management of patients with VWD, particularly in the emerging landscape of recombinant von Willebrand factor.
authors.affiliation: Departments of Clinical and Laboratory Haematology, Institute of Clinical Pathology and Medical Research and Westmead Hospital, Sydney Centres for Thrombosis and Haemostasis, Westmead, New South Wales, Australia.
authors.forename: Emmanuel J
authors.initials: EJ
authors.lastname: Favaloro
authors.affiliation: Departments of Clinical and Laboratory Haematology, Institute of Clinical Pathology and Medical Research and Westmead Hospital, Sydney Centres for Thrombosis and Haemostasis, Westmead, New South Wales, Australia.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pasalic
authors.affiliation: Departments of Clinical and Laboratory Haematology, Institute of Clinical Pathology and Medical Research and Westmead Hospital, Sydney Centres for Thrombosis and Haemostasis, Westmead, New South Wales, Australia.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Curnow
mesh_terms: D006801:Humans; D056728:von Willebrand Disease, Type 2 / Q000097:blood / Q000145:classification / Q000188:drug therapy / Q000235:genetics; D014841:von Willebrand Factor / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D014841:von Willebrand Factor