title: Diffusion tensor imaging in the normal breast: influences of fibroglandular tissue composition and background parenchymal enhancement.
abstract: OBJECTIVE
  To evaluate effects of fibroglandular tissue (FGT) composition and background parenchymal enhancement (BPE) on diffusion tensor imaging (DTI) parameters in normal breast tissue.
  
  
  METHODS
  DTI analysis was performed on 35 breasts with regions of interest drawn to include only normal tissue. Breasts were dichotomized by FGT composition and by BPE; DTI parameters were compared.
  
  
  RESULTS
  The λ1 principal diffusion coefficient was lower in breasts with moderate/marked BPE versus those with minimal/mild BPE (P=.039). All other parameters were unaffected.
  
  
  CONCLUSIONS
  λ1 is sensitive to differences in BPE within normal breast tissue that should be taken into account in DTI evaluation.
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065. Electronic address: Michael.j.plaza@gmail.com.
authors.forename: Michael Jonathan
authors.initials: MJ
authors.lastname: Plaza
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065. Electronic address: morrise@mskcc.org.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Morris
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065. Electronic address: thakurs@mskcc.org.
authors.forename: Sunitha B
authors.initials: SB
authors.lastname: Thakur
mesh_terms: D000328:Adult; D001940:Breast / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008875:Middle Aged; D015588:Observer Variation; D012189:Retrospective Studies
keywords: Breast; DTI; Diffusion; MRI; Tensor