title: [Modified technique of autologous transplantation of internal limiting membrane for macular hole].
abstract: BACKGROUND
  Autologous internal limiting membrane transplantation has allowed some cases of macular holes refractory to conventional surgery techniques to be treated. The purpose of this study is to describe the anatomical and functional outcomes of a modification of this technique in a case series of naïve macular hole patients.
  
  
  METHODS
  A consecutive case series study was performed on patients with naïve macular holes with a diameter greater than 600 μ. Best corrected visual acuity, clinical features of the macular area, and optical coherence tomography were recorded before the operation and at the end of follow-up in all patients studied. All patients underwent 23 Ga core vitrectomy, posterior hyaloid separation, and brilliant-blue assisted internal limiting membrane peeling. A small piece of the internal limiting membrane was peeled off to make a free flap, and this was trasplanted and placed inside the macular hole under perfluorocarbon liquids. Air-fluid exchange was performed and SF6 gas was injected at a non-expansile concentration.
  
  
  RESULTS
  The study included 5 eyes of 5 patients who underwent internal limiting membrane autograft. The mean age was 50.6 (SD 12.3) years. Four of the 5 cases had macular hole closure. The case where there was no closure of the macular hole was secondary to trauma. There was an improvement in visual acuity in all patients where the closing of the macular hole was achieved at the end of follow-up.
  
  
  CONCLUSIONS
  In this cases series of macular hole patients, the autologous internal limiting membrane transplantation was associated with an anatomical closure of the macular hole and functional improvement in most of the patients studied.
authors.affiliation: Servicio de Retina, Clínica David Unidad Oftalmológica, Morelia, Michoacán, México. Electronic address: tolodamota@yahoo.com.mx.
authors.forename: Sergio Eustolio
authors.initials: SE
authors.lastname: Hernández-da Mota
authors.affiliation: Servicio de Retina, Clínica David Unidad Oftalmológica, Morelia, Michoacán, México.
authors.forename: Francisco
authors.initials: F
authors.lastname: Béjar-Cornejo
mesh_terms: D000328:Adult; D001253:Astrocytes / Q000637:transplantation; D063928:Ependymoglial Cells / Q000637:transplantation; D005260:Female; D058752:Free Tissue Flaps; D006801:Humans; D008297:Male; D008566:Membranes / Q000637:transplantation*; D008875:Middle Aged; D012167:Retinal Perforations / Q000601:surgery*; D013459:Sulfur Hexafluoride; D041623:Tomography, Optical Coherence; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D013459:Sulfur Hexafluoride
keywords: Agujero macular; Autologous transplantation; Internal limiting membrane; Macular hole; Membrana limitante interna; Trasplante autólogo