title: [Immunosuppression after corneal transplantation : Clinical standards and novel approaches].
abstract: Corticosteroid eye drops are the mainstay of immunosuppressive therapy after routine lamellar and perforating corneal transplantation. Commonly occurring side effects are cataract formation and increased intraocular pressure. Alternative immunosuppressive agents could allow the dosage of glucocorticoids to be reduced. The antibiotic azithromycin is a candidate drug that showed anti-inflammatory properties in cell cultures and animal models and has positive effects on transplant rejection.
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg im Breisgau, Deutschland. katrin.wacker@uniklinik-freiburg.de.
authors.forename: K
authors.initials: K
authors.lastname: Wacker
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg im Breisgau, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Reinhard
mesh_terms: D016039:Corneal Transplantation / Q000009:adverse effects* / Q000592:standards*; D019317:Evidence-Based Medicine; D005858:Germany; D005938:Glucocorticoids / Q000008:administration & dosage; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy / Q000592:standards*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007634:Keratitis / Q000209:etiology / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents
keywords: Anti-inflammatory agents; Azithromycin; Corneal transplantation; Glucocorticoids; Graft rejection