title: Waist circumference is correlated with poorer cognition in elderly type 2 diabetes women.
abstract: Waist circumference is associated with type 2 diabetes (T2D) and cognition, yet the relationship between waist circumference and cognition in individuals with T2D is not well understood.
  
  
  
  We studied the relationship of waist circumference with five cognitive outcomes (executive functioning, language/semantic categorization, attention/working memory, episodic memory, and an overall cognition measure) in 845 cognitively normal elderly with type 2 diabetes (T2D).
  
  
  
  In women, waist circumference was correlated with significantly lower language and/or semantic categorization performance (P < .0001), executive functioning (P = .026), and overall cognition (P = .003) after controlling for age, education, BMI, and cardiovascular, diabetes-related, APOE ε4, and inflammatory potential confounders. Attention/working memory (P = .532) and episodic memory (P = .144) were not associated with waist circumference. These correlations were not found in men.
  
  
  
  These results suggest that central adiposity in elderly women with T2D may increase their risk for dementia.
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: rebecca.west@mssm.edu.
authors.forename: Rebecca K
authors.initials: RK
authors.lastname: West
authors.affiliation: The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: Ramit
authors.initials: R
authors.lastname: Ravona-Springer
authors.affiliation: Maccabi Healthcare Services, Tel-Aviv, Israel; Department of Family Medicine, The Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel.
authors.forename: Anthony
authors.initials: A
authors.lastname: Heymann
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: James
authors.initials: J
authors.lastname: Schmeidler
authors.affiliation: Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Leroith
authors.affiliation: The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: Keren
authors.initials: K
authors.lastname: Koifman
authors.affiliation: Simon Fraser University, Metro Vancouver, British Columbia, Canada; Surrey Memorial Hospital, Fraser Health, Metro Vancouver, British Columbia, Canada.
authors.forename: Ryan C N
authors.initials: RC
authors.lastname: D'Arcy
authors.affiliation: Simon Fraser University, Metro Vancouver, British Columbia, Canada; Surrey Memorial Hospital, Fraser Health, Metro Vancouver, British Columbia, Canada.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Guerrero-Berroa
authors.affiliation: The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: Rachel
authors.initials: R
authors.lastname: Preiss
authors.affiliation: The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: Hadas
authors.initials: H
authors.lastname: Hoffman
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Sano
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Silverman
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Schnaider-Beeri
mesh_terms: D000369:Aged, 80 and over; D000375:Aging; D003072:Cognition Disorders / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012727:Sex Characteristics; D055105:Waist Circumference / Q000502:physiology*
keywords: Cognitive performance; Dementia; Risk factors; Type 2 diabetes mellitus; Waist circumference