title: Preparation of ultrafine poly(methyl methacrylate-co-methacrylic acid) biodegradable nanoparticles loaded with ibuprofen.
abstract: Ibuprofen-loaded polymeric particles with around 9.2 nm in mean diameter, as determined by electron microscopy, dispersed in an aqueous media containing up to 12.8% solids were prepared by semicontinuous heterophase polymerization. The polymeric material is a (2/1 mol/mol) methyl methacrylate-co-methacrylic acid copolymer similar to Eudragit S100, deemed safe for human consumption and used in the manufacturing of drug-loaded pills as well as micro- and nanoparticles. The loading efficiency was 100%, attaining around 10-12% in drug content. Release studies showed that the drug is released from the nanoparticles at a slower rate than that in the case of free IB. Given their size as well as the pH values required for their dissolution, it is believed that this type of particles could be used as a basis for preparing nanosystems loaded with a variety of drugs.
authors.affiliation: a Departamento de Procesos de Polimerización , Centro de Investigación en Química Aplicada , Saltillo , México.
authors.forename: Hened
authors.initials: H
authors.lastname: Saade
authors.affiliation: a Departamento de Procesos de Polimerización , Centro de Investigación en Química Aplicada , Saltillo , México.
authors.forename: Ramón
authors.initials: R
authors.lastname: Diaz de León-Gómez
authors.affiliation: a Departamento de Procesos de Polimerización , Centro de Investigación en Química Aplicada , Saltillo , México.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Enríquez-Medrano
authors.affiliation: a Departamento de Procesos de Polimerización , Centro de Investigación en Química Aplicada , Saltillo , México.
authors.forename: Raúl Guillermo
authors.initials: RG
authors.lastname: López
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D007052:Ibuprofen
keywords: Biodegradable polymer; Eudragit S100; ibuprofen-loaded nanoparticles; polymeric nanoparticles