title: Novel therapeutic approaches for chronic kidney disease due to glomerular disorders.
abstract: Improved understanding of glomerular disease mechanisms over the past decade has led to the emergence of new and targeted therapeutic strategies for chronic kidney disease (CKD). Most promising among these are the administration of recombinant mutated human angiopoietin-like 4, sialic acid-related sugars that induce sialylation in vivo, compounds related to Bis-T-23, and immune depletion of the soluble urokinase receptor from the circulation. Taking these therapeutic strategies into clinical trials will be the first step away from repurposed and relatively toxic drugs currently used for treating kidney disease.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Maria
authors.initials: M
authors.lastname: Del Nogal-Avila
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Hector
authors.initials: H
authors.lastname: Donoro-Blazquez
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Manish K
authors.initials: MK
authors.lastname: Saha
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Marshall
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Lionel C
authors.initials: LC
authors.lastname: Clement
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Camille E A
authors.initials: CE
authors.lastname: Macé
authors.affiliation: Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama schugh@uabmc.edu sumant_s_chugh@rush.edu.
authors.forename: Sumant S
authors.initials: SS
authors.lastname: Chugh
mesh_terms: D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D011507:Proteinuria / Q000188:drug therapy; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy* / Q000473:pathology*
chemical_list: C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins
keywords: chronic kidney disease; drugs; proteinuria