title: Calix[8]arene functionalized single-walled carbon nanohorns for dual-signalling electrochemical sensing of aconitine based on competitive host-guest recognition.
abstract: A dual-signalling electrochemical approach has been developed towards aconitine based on competitive host-guest interaction by selecting methylene blue (MB) and p-sulfonated calix[8]arene functionalized single-walled carbon nanohorns (SCX8-SWCNHs) as the "reporter pair". Upon the presence of aconitine to the performed SCX8-SWCNHs·MB complex, the MB molecules are displaced by aconitine. This results in a decreased oxidation peak current of MB and the appearance of an oxidation peak of aconitine, and the changes of these signals correlate linearly with the concentration of aconitine. A linear response range of 1.00-10.00μM for aconitine with a low detection limit of 0.18μM (S/N=3) was obtained by using the proposed method. This method could be successfully utilized to detect aconitine in serum samples. This dual-signalling sensor can provide more sensitive target recognition and will have important applications in the sensitive and selective electrochemical detection of aconitine.
authors.affiliation: School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors.forename: Long
authors.initials: L
authors.lastname: Yang
authors.affiliation: School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ran
authors.affiliation: School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors.forename: Le
authors.initials: L
authors.lastname: Cai
authors.affiliation: School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors.forename: Yucong
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, PR China. Electronic address: zhaohui@yun.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: lcppp1974@sina.com.
authors.forename: Can-Peng
authors.initials: CP
authors.lastname: Li
mesh_terms: D000157:Aconitine / Q000097:blood*; D000276:Adjuvants, Immunologic / Q000097:blood*; D047250:Calixarenes / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D006801:Humans; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D000276:Adjuvants, Immunologic; D037742:Nanotubes, Carbon; D047250:Calixarenes; D000157:Aconitine
keywords: Aconitine; Calix[8]Arene; Competitive host–guest Recognition; Dual-signalling; Electrochemical determination; Single-walled carbon nanohorns