title: Does Roller Pump-Induced Pulsatile CPB Perfusion Affect Microvascular Fluid Shifts and Tissue Perfusion?
abstract: BACKGROUND
  Pulsatile versus nonpulsatile cardiopulmonary bypass (CPB) perfusion remains debated. Beneficial effects on tissue perfusion, inflammation, and microvascular fluid exchange have been linked to pulsatile perfusion by some investigators and denied by others. This study evaluated fluid extravasation and tissue perfusion during nonpulsatile or pulsatile roller pump-induced CPB perfusion.
  
  
  METHODS
  Fourteen pigs underwent roller pump-induced pulsatile (n = 7) or nonpulsatile CPB perfusion (n = 7) for 90 minutes. Fluid input/losses, colloid osmotic pressures (plasma/interstitium), hematocrit, serum electrolytes, serum proteins, tissue perfusion, and total tissue water content were measured, and plasma volume and fluid extravasation were calculated.
  
  
  RESULTS
  Fluid additions/losses, plasma volume, and fluid extravasation changed similarly in both groups during CPB with no between-group differences. Neither was between-group differences observed for tissue perfusion and total tissue water content, with one exception. Total tissue water content of the right (3.92 ± 0.26 versus 4.32 ± 0.28 g/g dry weight) and left ventricle (4.02 ± 0.25 versus 4.33 ± 0.24 g/g dry weight) was lowered in the pulsatile group.
  
  
  CONCLUSIONS
  No important differences were found between pulsatile and nonpulsatile CPB perfusion for microvascular fluid balance and tissue perfusion.
authors.affiliation: Department of Anesthesia and Surgical Services, Haukeland University Hospital, Bergen, Norway.
authors.forename: Bjørg
authors.initials: B
authors.lastname: Elvevoll
authors.affiliation: Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
authors.forename: Steinar
authors.initials: S
authors.lastname: Lundemoen
authors.affiliation: Department of Anesthesia and Surgical Services, Haukeland University Hospital, Bergen, Norway.
authors.forename: Øyvind S
authors.initials: ØS
authors.lastname: Svendsen
authors.affiliation: Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
authors.forename: Arve
authors.initials: A
authors.lastname: Mongstad
authors.affiliation: Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
authors.forename: Ketil
authors.initials: K
authors.lastname: Grong
authors.affiliation: Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
authors.forename: Venny L
authors.initials: VL
authors.lastname: Kvalheim
authors.affiliation: Department of Anesthesia and Surgical Services, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway. Electronic address: paul.husby@k1.uib.no.
authors.forename: Paul
authors.initials: P
authors.lastname: Husby
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D018495:Fluid Shifts / Q000502:physiology*; D006353:Heart-Assist Devices; D008833:Microcirculation / Q000502:physiology*; D011673:Pulsatile Flow; D013552:Swine