title: Progressive Transformation of Germinal Centers: Single-Center Experience of 33 Turkish Patients.
abstract: Progressive transformation of germinal centers (PTGCs) is a benign disease of the lymph nodes that is rarely associated with Hodgkin disease. We reviewed the clinical and pathologic features of PTGCs and the relationship of PTGCs with lymphoid neoplasia in an adult population. The data from 33 patients who were diagnosed with PTCGs were retrospectively analyzed. Of the 33 PTGC patients, 48.5% were men and 51.5% were women, with a mean age of 43.8 years at diagnosis. Most of the enlarged and excised lymph nodes were cervical and axillary. Diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma was detected concurrent with PTGC in 2 patients. Also, PTGCs was detected 3 years after the diagnosis of diffuse large B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and T-cell-rich B-cell lymphoma in 3 patients. No relapse was found in the patients with lymphoma, and no progression to lymphoma was detected during the follow-up of the other patients. PTGCs is not considered a premalignant entity; however, the development of lymphoma has been reported rarely. If PTGCs occurs in the follow-up process of patients with lymphoma, the follow-up intervals should be shortened.
authors.affiliation: Department of Hematology, Ege University School of Medicine, İzmir, Turkey. Electronic address: meldacomert@hotmail.com.
authors.forename: Melda Cömert
authors.initials: MC
authors.lastname: Özkan
authors.affiliation: Department of Pathology, Ege University School of Medicine, İzmir, Turkey.
authors.forename: Nazan
authors.initials: N
authors.lastname: Özsan
authors.affiliation: Department of Pathology, Ege University School of Medicine, İzmir, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Hekimgil
authors.affiliation: Department of Hematology, Ege University School of Medicine, İzmir, Turkey.
authors.forename: Güray
authors.initials: G
authors.lastname: Saydam
authors.affiliation: Department of Hematology, Ege University School of Medicine, İzmir, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Töbü
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D005260:Female; D018858:Germinal Center / Q000378:metabolism / Q000473:pathology; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis* / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D047368:Tumor Burden; D014421:Turkey; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Histopathology; Hodgkin lymphoma; Immunohistology; Lymphanedopathy; Non-Hodgkin lymphoma