title: [γ-Globin Inductive Therapy of β-thalassemia and Its Relationship with MicroRNA].
abstract: β-thalassemia is a chronic hemolytic anemia characterized by the reduction or absence of synthesis of β-globin chains because of the β-globin gene mutations. β-thalassemia belongs to the inherited hemoglobin disease, and occurs in some provinces of China, such as in Guangdong, Guangxi, Fujian, its prevalence is about 2%. The treatment of this disease include transfusion, iron chelating agent, hematopoietic stem cell transplantation, splenectomy, induced expression of Fetal Hemoglobin (HbF) and gene therapies. However, the mortality rate of this disease is still higher, thus some new treatments are urgently needed. In recent years, the study was mainly concentrated in 2 aspects: the normal β-globin gene transfer and endogenous γ-globin re-activation. Some studies showed that the expression of miRNAs was dysregulated in β-thalassemia. Some miRNAs could regulate γ-globin at posttranscriptional level, thus, the clarification of relationship between miRNAs and β-thalassemia is expected to provide experimental bases to β-thalassemia therapy. In this review, the induced therapy of γ-globin for β-thalassemia and its relationship with the miRNA are summarized.
authors.affiliation: Non-coding RNA Center, Yangzhou University Medical College, Yangzhou 225001, Jiangsu Province, China.|Department of Gastroenterology, Taixing People's Hospital Affiliated to Yangzhou University, Taixing 225400, Jiangsu Province, China.
authors.forename: Yao-Yao
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of Hematology, Subei People's Hospital Affiliated to Yangzhou University, Yangzhou 225000, Jiangsu Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gu
authors.affiliation: Non-coding RNA Center, Yangzhou University Medical College, Yangzhou 225001, Jiangsu Province, China. E-mail: yzuyu@sina.com.
authors.forename: Duo-Nan
authors.initials: DN
authors.lastname: Yu
mesh_terms: D002681:China; D005319:Fetal Hemoglobin / Q000378:metabolism; D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D055544:beta-Globins / Q000235:genetics; D017086:beta-Thalassemia / Q000628:therapy*; D055545:gamma-Globins / Q000627:therapeutic use*
chemical_list: D035683:MicroRNAs; D055544:beta-Globins; D055545:gamma-Globins; D005319:Fetal Hemoglobin