title: Wound healing and cancer progression in Opisthorchis viverrini associated cholangiocarcinoma.
abstract: Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). It was shown previously that O. viverrini-secreted proteins accelerate wound resolution in human cholangiocytes. Recombinant Ov-GRN-1 (O. viverrini-derived gene encoding granulin-like growth factor) induced angiogenesis and accelerated mouse wound healing. Given the striking similarities of wound healing and cancer progression, here we discuss the major implications of this finding for an infection-induced cancer of major public health significance in the developing world.
authors.affiliation: INSA-National Institute of Health Dr. Ricardo Jorge, Rua Alexandre Herculano, 321, 4000-055, Porto, Portugal. monicabotelho@hotmail.com.|I3S, Instituto de Investigação e Inovação da Universidade do Porto, Porto, Portugal. monicabotelho@hotmail.com.
authors.forename: Monica C
authors.initials: MC
authors.lastname: Botelho
authors.affiliation: INSA-National Institute of Health Dr. Ricardo Jorge, Rua Alexandre Herculano, 321, 4000-055, Porto, Portugal.
authors.forename: Helena
authors.initials: H
authors.lastname: Alves
authors.affiliation: Tropical Medicine Unit, Department for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Richter
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000150:complications / Q000469:parasitology* / Q000473:pathology; D001652:Bile Ducts / Q000469:parasitology; D001653:Bile Ducts, Intrahepatic / Q000469:parasitology; D018281:Cholangiocarcinoma / Q000150:complications / Q000469:parasitology*; D018450:Disease Progression; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D051379:Mice; D009889:Opisthorchiasis / Q000150:complications / Q000469:parasitology*; D009891:Opisthorchis / Q000235:genetics / Q000302:isolation & purification; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: Cholangiocarcinoma; Opisthorchis viverrini; Tumor progression; Wound healing