title: Fibrosarcomatous change in the background of dermatofibrosarcoma protuberans in male breast: Study of a rare case and review of the entity.
abstract: Dermatofibrosarcoma protuberans is a cutaneous soft tissue neoplasm with potential for local recurrence but distant metastasis is rare. Trunk and extremities are most commonly involved. This case presented as left-sided breast lump in a male patient. The patient underwent left-sided modified radical mastectomy. Tissues were subjected to histopathological and immunohistochemical test subsequently. The tumor cells showed storiform arrangement with nuclear pleomorphism and increased mitotic figures at places. They were reactive to CD34 and non-reactive to S-100, smooth muscle actin, desmin, cytokeratin and epithelial membrane antigen. The diagnosis of dermatofibrosarcoma protuberans with areas of fibrosarcomatous change was given. Though trunk is a common site for this tumor but its presentation as male breast lump has made the case unique.
authors.affiliation: Department of Pathology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India.
authors.forename: Birinchi Kumar
authors.initials: BK
authors.lastname: Saikia
authors.affiliation: Department of Pathology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India.
authors.forename: Indranil
authors.initials: I
authors.lastname: Das
authors.affiliation: Department of Pathology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India.
authors.forename: Gautam Kumar
authors.initials: GK
authors.lastname: Mandal
keywords: CD34; dermatofibrosarcoma protuberans; fibrosarcoma; mitotic figures