title: Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease.
abstract: Recent data have suggested a strong possible link between Type 2 Diabetes Mellitus and Alzheimer's disease (AD), although exact mechanisms linking the two are still a matter of research and debate. Interestingly, both are diseases with high incidence and prevalence in later years of life. The link appears so strong that some scientists use Alzheimer's and Type 3 Diabetes interchangeably. In depth study of recent data suggests that the anti diabetic drugs not only have possible role in treatment of Alzheimer's but may also arrest the declining cognitive functions associated with it. The present review gives an insight into the possible links, existing therapeutics and clinical trials of anti diabetic drugs in patients suffering from AD primarily or as co-morbidity. It may be concluded that the possible beneficial effects and usefulness of the current anti diabetic drugs in AD cannot be neglected and further research is required to achieve positive results. Currently, several drug trials are in progress to give conclusive evidence based data.
authors.affiliation: Department of Biosciences, Integral University, Lucknow, India.
authors.forename: Syed Mohd Danish
authors.initials: SM
authors.lastname: Rizvi
authors.affiliation: Department of Biosciences, Integral University, Lucknow, India.
authors.forename: Sibhghatulla
authors.initials: S
authors.lastname: Shaikh
authors.affiliation: Department of Physiology, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, India.
authors.forename: Shah Mohammad Abbas
authors.initials: SM
authors.lastname: Waseem
authors.affiliation: Center of Innovation in Personalized Medicine, Faculty of Applied Medical Sciences,King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Shazi
authors.initials: S
authors.lastname: Shakil
authors.affiliation: Center of Innovation in Personalized Medicine, Faculty of Applied Medical Sciences,King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Adel M
authors.initials: AM
authors.lastname: Abuzenadah
authors.affiliation: Department of Biosciences, Integral University, Lucknow, India.
authors.forename: Deboshree
authors.initials: D
authors.lastname: Biswas
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Shams
authors.initials: S
authors.lastname: Tabrez
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Ghulam Md
authors.initials: GM
authors.lastname: Ashraf
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Enzymoic, 7 Peterlee Pl, Hebersham, NSW 2770, Australia.
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
keywords: Alzheimer's disease; Type 2 Diabetes Mellitus; amyloid beta; anti-diabetic drugs; beta-secretase; co-transporters; sodium glucose