title: Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages.
abstract: Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.
authors.affiliation: Ludwig Maximilians Universität München, Frauenklinik Campus Innenstadt, Maistrasse 11, 80337 München, Germany. laura.unverdorben@gmx.de.
authors.forename: Laura
authors.initials: L
authors.lastname: Unverdorben
authors.affiliation: Ludwig Maximilians Universität München, Frauenklinik Campus Innenstadt, Maistrasse 11, 80337 München, Germany. thomas.haufe@googlemail.com.
authors.forename: Thomas
authors.initials: T
authors.lastname: Haufe
authors.affiliation: Ludwig Maximilians Universität München, Frauenklinik Campus Innenstadt, Maistrasse 11, 80337 München, Germany. laurasantoso@googlemail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Santoso
authors.affiliation: Ludwig Maximilians Universität München, Frauenklinik Campus Innenstadt, Maistrasse 11, 80337 München, Germany. simone.hofmann@med.uni-muenchen.de.
authors.forename: Simone
authors.initials: S
authors.lastname: Hofmann
authors.affiliation: Ludwig Maximilians Universität München, Frauenklinik Campus Innenstadt, Maistrasse 11, 80337 München, Germany. udo.jeschke@med.uni-muenchen.de.
authors.forename: Udo
authors.initials: U
authors.lastname: Jeschke
authors.affiliation: Ludwig Maximilians Universität München, Frauenklinik Campus Innenstadt, Maistrasse 11, 80337 München, Germany. stefan.hutter@med.uni-muenchen.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Hutter
mesh_terms: D000022:Abortion, Spontaneous / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D037501:Galectin 2 / Q000378:metabolism; D037502:Galectin 3 / Q000378:metabolism; D037161:Galectins / Q000378:metabolism*; D006801:Humans; D008856:Microscopy, Fluorescence; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology
chemical_list: D037501:Galectin 2; D037502:Galectin 3; D037161:Galectins
keywords: decidua; galectins; placenta; spontaneous and recurrent miscarriage; trophoblast