title: Identification of a new tadalafil analogue, dipropylaminopretadalafil, in a dietary supplement.
abstract: A novel tadalafil analogue in a dietary supplement was found by drug-adulteration screening and isolated by column chromatography and HPLC. Based on extensive 1D- and 2D-NMR and mass spectral analyses, the structure of this new compound was determined as 2-(N,N-dipropyl acetyl) 3-methyl 1-(benzo[d][1,3]dioxol-5-yl)-3,4-dihydro-1H-pyrido[3,4-b]indole-3-carboxylate - its common name is dipropylaminopretadalafil.
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C).
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Huang
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C).
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Lee
authors.affiliation: b Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources , China Medical University , Taichung , Taiwan (R.O.C).
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Lin
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C).
authors.forename: Chia-Fen
authors.initials: CF
authors.lastname: Tsai
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C).
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Cheng
mesh_terms: D002851:Chromatography, High Pressure Liquid; D019587:Dietary Supplements / Q000032:analysis; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D000068581:Tadalafil / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry
chemical_list: C000614364:dipropylaminopretadalafil; D000068581:Tadalafil
keywords: Tadalafil analogue; adulterated food supplements; dipropylaminopretadalafil