title: Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response.
abstract: Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integration. A series of cellular and molecular events following biomaterial implantation poses an important bottleneck for developing breakthrough solutions. With inflammation increasingly recognized as a crucial component influencing regeneration, immunomodulation or immuno-engineering has emerged as a potential solution to overcome this key challenge in regenerative medicine. We postulate possibilities to utilize biomaterial physicochemical modifications to modulate the host inflammatory response and develop strategies for effective biomaterial integration. Biomaterial-based immunomodulation strategies can significantly ameliorate the outcomes of medical implants and tissue engineering therapies.
authors.affiliation: Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA.
authors.forename: Ajaykumar
authors.initials: A
authors.lastname: Vishwakarma
authors.affiliation: Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA.
authors.forename: Nupura S
authors.initials: NS
authors.lastname: Bhise
authors.affiliation: Protip Medical, 8 Place de l'Hopital, 67000 Strasbourg, France.
authors.forename: Marta B
authors.initials: MB
authors.lastname: Evangelista
authors.affiliation: Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA; Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Rouwkema
authors.affiliation: Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA.
authors.forename: Mehmet R
authors.initials: MR
authors.lastname: Dokmeci
authors.affiliation: Division of Immunology, Queen's Medical Centre, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, UK.
authors.forename: Amir M
authors.initials: AM
authors.lastname: Ghaemmaghami
authors.affiliation: Protip Medical, 8 Place de l'Hopital, 67000 Strasbourg, France; INSERM UMR 1121, 11 rue Humann, 67085 Strasbourg, France.
authors.forename: Nihal Engin
authors.initials: NE
authors.lastname: Vrana
authors.affiliation: Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02155, USA; College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia. Electronic address: alik@bwh.harvard.edu.
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry*; D005549:Foreign-Body Reaction / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology*; D056747:Immunomodulation / Q000187:drug effects / Q000276:immunology*; D008422:Materials Testing; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials
keywords: biomaterials; hydrogel; immune response; immunomodulation; macrophages