title: Adhesion GPCRs in immunology.
abstract: Adhesion GPCRs (aGPCRs) form a subfamily of the large GPCR super family. Most aGPCRs are characterised by a non-covalent bipartite structure that consists of a large extracellular domain and a membrane-spanning 7 transmembrane domain. Typically, aGPCRs can combine cell adhesion by the large extracellular domain with intracellular signalling by the 7 transmembrane domain. Immune responses rely on cellular communication and subsequent defence reactions. Indeed, aGPCR ADGRB1 and members of the ADGRE class have been linked to processes like phagocytosis, leucocyte activation and migration. Nevertheless, research is hampered by absence of endogenous ligands, unknown activity of generated antibodies and non-identified signalling pathways. Yet, based on their membrane localisation and important function, aGPCRs could be novel drug targets to modulate leucocyte function.
authors.affiliation: Vrije Universiteit Amsterdam, Department of Medicinal Chemistry, O|2 Building, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address: s.nijmeijer@vu.nl.
authors.forename: Saskia
authors.initials: S
authors.lastname: Nijmeijer
authors.affiliation: Vrije Universiteit Amsterdam, Department of Medicinal Chemistry, O|2 Building, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address: h.f.vischer@vu.nl.
authors.forename: Henry F
authors.initials: HF
authors.lastname: Vischer
authors.affiliation: Vrije Universiteit Amsterdam, Department of Medicinal Chemistry, O|2 Building, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address: r.leurs@vu.nl.
authors.forename: Rob
authors.initials: R
authors.lastname: Leurs
mesh_terms: D042501:Angiogenic Proteins / Q000276:immunology / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology* / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology; D043562:Receptors, G-Protein-Coupled / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
chemical_list: C468226:ADGRB1 protein, human; D042501:Angiogenic Proteins; D015815:Cell Adhesion Molecules; D043562:Receptors, G-Protein-Coupled
keywords: Adhesion; GPCR; Immunology; Leucocytes; Signalling; aGPCR