title: Novel meloxicam releasing electrospun polymer/ceramic reinforced biodegradable membranes for periodontal regeneration applications.
abstract: Periodontal disease is associated with the destruction of periodontal tissues, along with other disorders/problems including inflammation of tissues and severe pain. This paper reports the synthesis of meloxicam (MX) immobilized biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) based electrospun (e-spun) fibers and films. Electrospinning was employed to produce drug loaded fibrous mats, whereas films were generated by solvent casting method. In-vitro drug release from materials containing varying concentrations of MX revealed that the scaffolds containing higher amount of drug showed comparatively faster release. During initial first few hours fast release was noted from membranes and films; however after around 5h sustained release was achieved. The hydrogels showed good swelling property, which is highly desired for soft tissue engineered implants. To investigate the biocompatibility of our synthesized materials, VERO cells (epithelial cells) were selected and cell culture results showed that these all materials were non-cytotoxic and also these cells were very well proliferated on these synthesized scaffolds. These properties along with the anti-inflammatory potential of our fabricated materials suggest their effective utilization in periodontital treatments.
authors.affiliation: Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000, Pakistan. Electronic address: drmyar@ciitlahore.edu.pk.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yar
authors.affiliation: Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000, Pakistan; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
authors.forename: Ariba
authors.initials: A
authors.lastname: Farooq
authors.affiliation: Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000, Pakistan.
authors.forename: Lubna
authors.initials: L
authors.lastname: Shahzadi
authors.affiliation: Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000, Pakistan.
authors.forename: Abdul Samad
authors.initials: AS
authors.lastname: Khan
authors.affiliation: Department of Allied Health Sciences and Chemical Pathology, Department of Human Genetics and Molecular Biology, University of Health Sciences, Lahore, Pakistan.
authors.forename: Nasir
authors.initials: N
authors.lastname: Mahmood
authors.affiliation: Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Rauf
authors.affiliation: Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000, Pakistan.
authors.forename: Aqif Anwar
authors.initials: AA
authors.lastname: Chaudhry
authors.affiliation: Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000, Pakistan; Department of Materials Science and Engineering, The Kroto Research Institute, The University of Sheffield, North Campus, Broad Lane, Sheffield S3 7HQ, United Kingdom.
authors.forename: Ihtesham Ur
authors.initials: IU
authors.lastname: Rehman
mesh_terms: D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004343:Drug Implants / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000077239:Meloxicam; D008567:Membranes, Artificial; D010510:Periodontal Diseases; D011142:Polyvinyl Alcohol / Q000493:pharmacokinetics / Q000494:pharmacology; D013843:Thiazines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D063566:Biodegradable Plastics; D004343:Drug Implants; D008567:Membranes, Artificial; D013843:Thiazines; D013844:Thiazoles; D011142:Polyvinyl Alcohol; D048271:Chitosan; D017886:Durapatite; D000077239:Meloxicam
keywords: Chitosan; Hydroxyapatite; NSAIDs; Periodontitis; VERO cells