title: Reward Systems in the Brain and Nutrition.
abstract: The taste cortex in the anterior insula provides separate and combined representations of the taste, temperature, and texture of food in the mouth independently of hunger and thus of reward value and pleasantness. One synapse on, in the orbitofrontal cortex, these sensory inputs are combined by associative learning with olfactory and visual inputs for some neurons, and these neurons encode food reward value in that they respond to food only when hunger is present and in that activations correlate linearly with subjective pleasantness. Cognitive factors, including word-level descriptions and selective attention to affective value, modulate the representation of the reward value of taste, olfactory, and flavor stimuli in the orbitofrontal cortex and a region to which it projects, the anterior cingulate cortex. These food reward representations are important in the control of appetite and food intake. Individual differences in reward representations may contribute to obesity, and there are age-related differences in these reward representations. Implications of how reward systems in the brain operate for understanding, preventing, and treating obesity are described.
authors.affiliation: Oxford Centre for Computational Neuroscience, Oxford, United Kingdom; email: Edmund.Rolls@oxcns.org.
authors.forename: Edmund T
authors.initials: ET
authors.lastname: Rolls
mesh_terms: D000818:Animals; D001069:Appetite Regulation; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003657:Decision Making; D019317:Evidence-Based Medicine; D005247:Feeding Behavior; D005518:Food Preferences; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism*; D009752:Nutritional Status; D009765:Obesity / Q000000981:diagnostic imaging / Q000517:prevention & control / Q000523:psychology* / Q000628:therapy; D009928:Organ Specificity; D012201:Reward; D012528:Satiety Response
keywords: fat texture; food reward; hunger; obesity; olfaction; orbitofrontal cortex; taste