title: Neuropathy in the DCCT/EDIC-What Was Done Then and What We Would Do Better Now.
abstract: The Diabetes Control and Complications Trial (DCCT) and its epidemiological follow-up, the Epidemiology of Diabetes Interventions and Complications (EDIC) provide important insight on the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy in patients with type 1 diabetes and on the impact of intensive treatment of hyperglycemia on disease progression. This chapter summarizes the design and methods used for neuropathy evaluations both in the DCCT and in EDIC, the characteristics of the DCCT/EDIC patient population, and summarizes the findings of the DCCT/EDIC relative to neuropathic complications of type 1 diabetes. Lessons learned from the DCCT and EDIC experiences of longitudinal assessments of neuropathic complications are also reviewed.
authors.affiliation: University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address: rpbusui@umich.edu.
authors.forename: R
authors.initials: R
authors.lastname: Pop-Busui
authors.affiliation: University of Michigan Medical School, Ann Arbor, MI, United States.
authors.forename: C
authors.initials: C
authors.lastname: Martin
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000453:epidemiology*; D003929:Diabetic Neuropathies / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D016896:Treatment Outcome
keywords: Autonomic neuropathy; Diabetes Control and Complications Trial; Distal symmetrical polyneuropathy; Epidemiology of Diabetes Interventions and Complications; Natural history