title: Physicochemical fingerprinting of thermal waters of Beira Interior region of Portugal.
abstract: Mineral natural waters and spas have been used for therapeutic purposes for centuries, with Portugal being a very rich country in thermal waters and spas that are mainly distributed by northern and central regions where Beira Interior region is located. The use of thermal waters for therapeutic purposes has always been aroused a continuous interest, being dependent on physicochemical fingerprinting of this type of waters the indication for a treatment in a specific pathological condition. In the present work, besides a literature review about the physicochemical composition of the thermal waters of the Beira Interior region and its therapeutic indications, it was carried out an exhaustive multivariate analysis-principal component analysis and cluster analysis-to assess the correlation between different physicochemical parameters and the therapeutic indications claims described for these spas and thermal waters. These statistical methods used for data analysis enables classification of thermal waters compositions into different groups, regarding to the different variable selected, making possible an interpretation of variables affecting water compositions. Actually, Monfortinho and Longroiva are clearly quite different of the others, and Cró and Fonte Santa de Almeida appear together in all analysis, suggesting a strong resemblance between these waters. Thereafter, the results obtained allow us to demonstrate the role of major components of the studied thermal waters on a particular therapeutic purpose/indication and hence based on compositional and physicochemical properties partially explain their therapeutic qualities and beneficial effects on human health. This classification agreed with the results obtained for the therapeutic indications approved by the Portuguese National Health Authority and proved to be a valuable tool for the regional typology of mineral medicinal waters, constituting an important guide of the therapeutic armamentarium for well and specific-oriented pathological disturbs.
authors.affiliation: CPIRN-UDI/IPG, Centro de Potencial e Inovação em Recursos Naturais, Unidade de Investigação para o Desenvolvimento do Interior, Instituto Politécnico da Guarda, Av. Dr. Francisco de Sá Carneiro, Nº 50, 6300-559, Guarda, Portugal.
authors.forename: A R T S
authors.initials: ARTS
authors.lastname: Araujo
authors.affiliation: LAQV/REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
authors.forename: M C
authors.initials: MC
authors.lastname: Sarraguça
authors.affiliation: CPIRN-UDI/IPG, Centro de Potencial e Inovação em Recursos Naturais, Unidade de Investigação para o Desenvolvimento do Interior, Instituto Politécnico da Guarda, Av. Dr. Francisco de Sá Carneiro, Nº 50, 6300-559, Guarda, Portugal.
authors.forename: M P
authors.initials: MP
authors.lastname: Ribeiro
authors.affiliation: CPIRN-UDI/IPG, Centro de Potencial e Inovação em Recursos Naturais, Unidade de Investigação para o Desenvolvimento do Interior, Instituto Politécnico da Guarda, Av. Dr. Francisco de Sá Carneiro, Nº 50, 6300-559, Guarda, Portugal. coutinho@ipg.pt.
authors.forename: P
authors.initials: P
authors.lastname: Coutinho
mesh_terms: D055598:Chemical Phenomena; D008900:Mineral Waters / Q000032:analysis* / Q000627:therapeutic use; D015999:Multivariate Analysis; D011174:Portugal; D025341:Principal Component Analysis
chemical_list: D008900:Mineral Waters
keywords: Beira Interior; Multivariate analysis; Physicochemical composition; Portugal; Therapeutic indications; Thermal water