title: CMPF: A Biomarker for Type 2 Diabetes Mellitus Progression?
abstract: The factors that precipitate the transition from insulin resistance to type 2 diabetes mellitus (T2DM) remain elusive. A recent study showed that circulating levels of the furan fatty acid (FA) metabolite 3-Carboxy-4-Methyl-5-Propyl-2-Furanopropanoic Acid (CMPF) increase in individuals who progress from prediabetes to T2DM. CMPF increases oxidative stress and impairs insulin granule maturation and secretion.
authors.affiliation: Montreal Diabetes Research Center, CRCHUM, Montreal, QC, Canada.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Koppe
authors.affiliation: Montreal Diabetes Research Center, CRCHUM, Montreal, QC, Canada; Department of Medicine, University of Montreal, Montreal, QC, Canada. Electronic address: vincent.poitout@umontreal.ca.
authors.forename: Vincent
authors.initials: V
authors.lastname: Poitout
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology; D005663:Furans / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D011236:Prediabetic State / Q000378:metabolism* / Q000473:pathology; D011422:Propionates / Q000378:metabolism*
chemical_list: C468134:3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; D015415:Biomarkers; D005663:Furans; D007328:Insulin; D011422:Propionates