title: New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sarcophyton ehrenbergi.
abstract: Chemical investigation on the soft coral Sarcophyton ehrenbergi collected from the Xisha Islands of the South China Sea have led to the isolation of eight cembranoids including five new ones, sarcophytonoxides A-E (1-5). The structures of new cembranoids (1-5) were determined by spectroscopic analysis and comparison of the NMR data with those of related analogues. The cytotoxicities of compounds 1-8 against human ovarian cancer cell line A2780 were also evaluated.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. tanggh5@mail.sysu.edu.cn.
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. sunzh@gdim.cn.|State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangzhou 510070, China. sunzh@gdim.cn.
authors.forename: Zhang-Hua
authors.initials: ZH
authors.lastname: Sun
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zouyh5@mail2.sysu.edu.cn.
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Zou
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. yinsh2@mail.sysu.edu.cn.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D004224:Diterpenes; C037071:cembrane
keywords: Sarcophyton ehrenbergi; cembranoids; marine natural product