title: Levels of Adipokines in Amniotic Fluid and Cord Blood Collected from Dichorionic-Diamniotic Twins Discordant for Fetal Growth.
abstract: To compare the concentrations of adipokines in amniotic fluid (AF) and cord blood collected from discordant dichorionic-diamniotic (DCDA) twin fetuses.
  
  
  
  The study population included DCDA twins discordant for fetal growth (birth weight difference >10%) who either underwent mid-trimester amniocentesis for routine clinical indication (Cohort 1) or whose amniotic fluid was collected at the time of delivery (Cohort 2). In both cohorts, cord blood was collected at delivery.
  
  
  
  A total of 92 twin pairs were enrolled (n = 49 in Cohort 1; n = 43 in Cohort 2). In Cohort 1, the concentrations of adiponectin (median, 68.5 ng/mL vs 61.4 ng/mL; p<0.05) and leptin (median, 13.9 ng/mL vs 11.2 ng/mL; p<0.1) in mid-trimester AF were significantly higher in smaller compared with larger twins. In Cohort 2, the concentration of serpin E1 (median, 246.0 ng/mL vs 182.8 ng/mL; p<0.01) in AF at delivery was significantly higher in smaller twins, but no difference was noted in adiponectin and leptin concentrations. Levels of adiponectin (median, 10425.5 ng/mL vs 11552.0 ng/mL; p<0.005) and leptin (median, 2.1 ng/mL vs 2.6 ng/mL; p<0.005) were significantly lower in the cord blood of smaller twins whereas cord blood concentrations of serpin E1 (median, 15.5 ng/mL vs 13.3 ng/mL; p<0.05) was higher in the smaller twins.
  
  
  
  In discordant DCDA twin pairs, concentrations of adiponectin, leptin, and serpin E1 in mid-trimester AF, AF at delivery, and cord blood at birth vary significantly but predictably between the smaller and larger twins.
authors.affiliation: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Seung Mi
authors.identifier: 0000-0002-2543-0408
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Joong Shin
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Obstetrics & Gynecology, Tufts University School of Medicine, Boston, Massachusetts, United States of America.
authors.forename: Errol R
authors.initials: ER
authors.lastname: Norwitz
authors.affiliation: Department of Obstetrics & Gynecology, University of Health Sciences, Vientiane, Lao PDR.
authors.forename: Sitthysack
authors.initials: S
authors.lastname: Panyavatthanasinh
authors.affiliation: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.|Department of Obstetrics & Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Sun Min
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: JoonHo
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Chan-Wook
authors.initials: CW
authors.lastname: Park
authors.affiliation: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.|Department of Obstetrics & Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Byoung Jae
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jong Kwan
authors.initials: JK
authors.lastname: Jun
mesh_terms: D054392:Adipokines / Q000032:analysis* / Q000097:blood* / Q000378:metabolism; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D001724:Birth Weight / Q000502:physiology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D047109:Fetal Development / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000032:analysis / Q000097:blood / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis / Q000097:blood / Q000378:metabolism; D011247:Pregnancy; D011264:Pregnancy Trimesters; D012189:Retrospective Studies; D014429:Twins, Dizygotic
chemical_list: D054392:Adipokines; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1