title: Experimental study regarding the biocompatibility test of the Prolene (polypropylene abdominal mesh) product.
abstract: The polypropylene mesh, although is one of the most used prosthetic biomaterials for abdominal wall defects, proved not to be completely inert, generating from precocious foreign body inflammatory reactions (varying by individual reactivity, the amount of used material and its structure), to late complications such as chronic infections, stercoral fistulae or mesh migration. The present paper was aimed at studying the behavior of implants of this material in three different areas of the body of experimental animals, as follows: intramuscular, intraperitoneal and extraperitoneal. The observation time was 21 days and 90 days. We observed foreign body reactions induced locally by the mesh that remains temporary, generating a moderate number of macrophages and foreign body giant cells. The material did not systemically affect the healing and the scaring of the surgical wounds, but in all three implant areas, the polypropylene mesh generated locally a fibrous proliferation reaction of neoformation tissue, which wrapped and secured the implanted product on all surfaces.
authors.affiliation: Department of Plastic Surgery and Reconstructive Microsurgery, Elias Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; ruxandrasinescu@gmail.com.
authors.forename: Elena Violeta
authors.initials: EV
authors.lastname: Radu
authors.forename: IonuŢ Simion
authors.initials: IS
authors.lastname: Coman
authors.forename: Oana Ilona
authors.initials: OI
authors.lastname: David
authors.forename: Ştefan Iulian
authors.initials: ŞI
authors.lastname: Bedereag
authors.forename: Ruxandra Diana
authors.initials: RD
authors.lastname: Sinescu
authors.forename: Valentin Titus
authors.initials: VT
authors.lastname: Grigorean
authors.forename: Mihai
authors.initials: M
authors.lastname: Popescu
authors.forename: Cristian Dumitru
authors.initials: CD
authors.lastname: Lupaşcu
authors.forename: Nicolae Dan
authors.initials: ND
authors.lastname: Straja
authors.forename: Ioan Petre
authors.initials: IP
authors.lastname: Florescu
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing / Q000379:methods*; D010537:Peritoneum / Q000473:pathology / Q000601:surgery; D011126:Polypropylenes / Q000737:chemistry*; D017208:Rats, Wistar; D013526:Surgical Mesh; D013997:Time Factors; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes