title: Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta-analysis of Randomized Controlled Trials.
abstract: This meta-analysis aimed to evaluate the immunomodulating function of Yupingfeng Formula (YPFF) in children with recurrent respiratory tract infections (RRTIs). The PubMed, EMBASE, Cochrane Library, CNKI and WanFang databases were searched for randomized controlled trials comparing with and without YPFF for RRTIs in children. Twelve trials with 1236 patients were identified. Adjuvant treatment with YPFF significantly increased serum levels of IgA (weighted mean difference [WMD] 0.33 mg/mL; 95% confidence interval [CI] 0.20 to 0.45), IgG (WMD 1.36 mg/mL; 95% CI 1.06 to 1.65), IgM (WMD 0.16 mg/mL; 95% CI 0.02 to 0.31), and CD3(+) T-lymphocytes (WMD 10.16%; 95% CI 4.62 to 15.69) but not CD4(+) T-lymphocytes (WMD 3.16%; 95% CI -0.27 to 6.59) and CD8(+) T-lymphocytes (WMD -0.84%; 95% CI -2.50 to 0.81). YPFF also reduced the frequency of RRTIs (WMD -3.80 times; 95% CI -4.86 to -2.74) and increased total effective rates of symptom improvement (risk ratio: 1.44; 95% CI 1.19 to 1.75). Adjuvant treatment with YPFF could improve total clinical effective rate and decrease the frequency of respiratory tract infections in children with RRTIs. The beneficial effects of YPFF may be correlated to its immunomodulating action. More well-designed trials with larger sample sizes are needed to evaluate its efficacy and safety. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Ruiren
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Zhengzheng
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Sui
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Chunhong
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D002648:Child; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal; D007155:Immunologic Factors; C532967:yupingfeng
keywords: Yupingfeng; children; immunomodulating function; meta-analysis; recurrent respiratory tract infections