title: [Analysis of Risk Factors for Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation].
abstract: OBJECTIVE
  To analyze the incidence of cytomegalovirus infection and related risk factors after allogeneic hematopoietic cell transplantation and to develop a rational strategy for the preemptive treatment of CMV infection.
  
  
  METHODS
  The clinical data of 398 patients undergoing allogeneic hematopoietic cell transplantation from December 2011 to December 2014 were analyzed retrospectively by using a Kaplan Meier analysis and Logistics model.
  
  
  RESULTS
  Out of 398 patients 233 developed post-transplant CMV infection (58.5%). Univariate analysis showed that HLA mismatch, ATG administration, acute graft versus host disease (aGVHD), using prednisone ≥ 1 mg/kg body weight or equivalent were associated with increase of CMV infection. Multivariate analysis showed that HLA mismatch (HR = 2.765, P = 0.000), ATG administration (HR = 3.866, P = 0.000), using prednisone ≥ 1 mg/kg body weight or equivalent (HR = 4.767, P = 0.000) also were associated with increase of CMV infection.
  
  
  CONCLUSIONS
  HLA mismatch, ATG administration, using prednisone ≥ 1 mg/kg are risk factors for CMV reaction.
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
authors.forename: Bing-Han
authors.initials: BH
authors.lastname: Zou
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Xu
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
authors.forename: Zhuo-Qing
authors.initials: ZQ
authors.lastname: Qiao
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
authors.forename: Yu-Hang
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Chen
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
authors.forename: Liang-Ding
authors.initials: LD
authors.lastname: Hu
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China. E-mail: zb307ctc@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China. E-mail: chenhu217@aliyun.com.
authors.forename: Hu
authors.initials: H
authors.lastname: Chen
mesh_terms: D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D015999:Multivariate Analysis; D011241:Prednisone / Q000008:administration & dosage; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D011241:Prednisone