title: Reduction-Responsive Guanine Incorporated into G-Quadruplex-Forming DNA.
abstract: Stimulus-responsive biomolecules are attractive targets to understand biomolecule behaviour as well as to explore their therapeutic and diagnostic applications. We demonstrate that a reduction-responsive cleavable group (chemically caged unit) introduced into the guanine ring enables modulation of the secondary structure transition of an oligonucleotide in a reduction-responsive and traceless manner leaving the unmodified oligonucleotide of interest. This simple but robust strategy could yield a variety of stimuli-responsive oligonucleotides.
authors.affiliation: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan. m_ikeda@gifu-u.ac.jp.|Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan. m_ikeda@gifu-u.ac.jp.|United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan. m_ikeda@gifu-u.ac.jp.
authors.forename: Masato
authors.identifier: http://orcid.org/0000-0003-4097-8292
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kamimura
authors.affiliation: Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hayakawa
authors.affiliation: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan.|Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Shibata
authors.affiliation: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan. ykkitade@gifu-u.ac.jp.|Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan. ykkitade@gifu-u.ac.jp.|United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan. ykkitade@gifu-u.ac.jp.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kitade
mesh_terms: D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D009841:Oligonucleotides; D006147:Guanine; D004247:DNA
keywords: DNA structures; G-quadruplexes; cleavage reactions; conjugation; stimuli-responsive