title: Green synthesized gold nanoparticles decorated graphene oxide for sensitive determination of chloramphenicol in milk, powdered milk, honey and eye drops.
abstract: A simple and rapid green synthesis using Bischofia javanica Blume leaves as reducing agent was developed for the preparation of gold nanoparticles (AuNPs). AuNPs decorated graphene oxide (AuNPs/GO) was prepared and employed for the sensitive amperometric determination of chloramphenicol. The green biosynthesis requires less than 40s to reduce gold salts to AuNPs. The formations of AuNPs and AuNPs/GO were evaluated by scanning electron and atomic force microscopies, UV-Visible and energy dispersive X-ray spectroscopies, X-ray diffraction studies, and electrochemical methods. AuNPs/GO composite film modified electrode was fabricated and shown excellent electrocatalytic ability towards chloramphenicol. Under optimal conditions, the amperometric sensing platform has delivered wide linear range of 1.5-2.95μM, low detection limit of 0.25μM and high sensitivity of 3.81μAμM(-1)cm(-2). The developed sensor exhibited good repeatability and reproducibility, anti-interference ability and long-term storage stability. Practical feasibility of the sensor has been demonstrated in food samples (milk, powdered milk and honey) and pharmaceutical sample (eye drops). The green synthesized AuNPs/GO composite has great potential for analysis of food samples in food safety measures.
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
authors.forename: R
authors.initials: R
authors.lastname: Karthik
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
authors.forename: Mani
authors.initials: M
authors.lastname: Govindasamy
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC. Electronic address: smchen78@ms15.hinet.net.
authors.forename: Shen-Ming
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Graduate Institute of Biomedical and Biochemical Engineering, National Taipei University of Technology, Taipei, Taiwan, ROC.
authors.forename: Veerappan
authors.initials: V
authors.lastname: Mani
authors.affiliation: Chemistry Division, Center for General Education, Chang Gung University, Taoyuan, Taiwan, ROC; Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. Electronic address: blou@mail.cgu.edu.tw.
authors.forename: Bih-Show
authors.initials: BS
authors.lastname: Lou
authors.affiliation: Department of Materials and Mineral Resources Engineering, No. 1, Sec. 3, Chung-Hsiao East Rd., National Taipei University of Technology, Taipei, Taiwan, ROC.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Devasenathipathy
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
authors.forename: Yu-Shen
authors.initials: YS
authors.lastname: Hou
authors.affiliation: Department of Chemistry, Thiagarajar College, Madurai 625009, India.
authors.forename: A
authors.initials: A
authors.lastname: Elangovan
mesh_terms: D000818:Animals; D002701:Chloramphenicol / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006722:Honey / Q000032:analysis*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008892:Milk / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D013499:Surface Properties
chemical_list: D009883:Ophthalmic Solutions; D010087:Oxides; D011208:Powders; D002701:Chloramphenicol; D006046:Gold; D006108:Graphite
keywords: Antibiotics; Chloramphenicol; Eye drops; Food safety; Graphene oxide; Green synthesis; Metal nanoparticles; Milk; Modified electrode; Plant extracts