title: Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review.
abstract: The aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD). DBP phenotypes were identified in the groups: control (n = 306), men suffering from CAD (n = 154), and long-lived individuals (n = 108). Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel. Distribution of DBP phenotypes in the study groups was found to be in Hardy-Weinberg equilibrium. Gc1s-1s phenotype and Gc1s allele frequency in CAD groups were significantly higher than in control, and Gc1s allele frequency was found significantly more often in CAD compared with long-lived group (p < 0.05). The Gc2 allele frequency in control was higher as compared with Gc2 frequency in CAD group (p < 0.05). The Gc2-2 phenotype was more frequent in long-lived survivors than in the CAD group (p < 0.05). It was found that the Gc1s allele significantly increased the risk of CAD with the odds ratio (OR) equal to 1.45 (p < 0.02) and showed Gc2 to be related with a decreased risk of CAD (OR = 0.69; p < 0.03). Authors review the role of DBP in resistance to atherosclerosis and cancer as the main longevity determinants.
authors.affiliation: Laboratory of Cancerogenesis and Cancer Epidemiology, Scientific Research Center, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, Lithuania; Department of Biolaw, Mykolas Romeris University, Ateities 21, LT-08303 Vilnius, Lithuania.
authors.forename: Donatas
authors.initials: D
authors.lastname: Stakisaitis
authors.affiliation: Department of Geriatrics, Medical Academy, Lithuanian University of Health Sciences, A. Mickevičiaus 9, LT-44307 Kaunas, Lithuania.
authors.forename: Vita
authors.initials: V
authors.lastname: Lesauskaitė
authors.affiliation: Laboratory of Cancerogenesis and Cancer Epidemiology, Scientific Research Center, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, Lithuania.
authors.forename: Milda
authors.initials: M
authors.lastname: Girdauskaitė
authors.affiliation: Radiation and Medical Oncology Clinics, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, Lithuania.
authors.forename: Ernestas
authors.initials: E
authors.lastname: Janulionis
authors.affiliation: Oncosurgery Clinics, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, Lithuania.
authors.forename: Albertas
authors.initials: A
authors.lastname: Ulys
authors.affiliation: Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, LT-50161 Kaunas, Lithuania.
authors.forename: Rimantas
authors.initials: R
authors.lastname: Benetis