title: Ticagrelor-induced Sweet Syndrome: an unusual dermatologic complication after percutaneous coronary intervention.
abstract: A 73-year-old male underwent cardiac catheterization and received two Everolimus drug eluting stents for 80 % stenotic lesions in the left anterior descending and right coronary arteries. He was discharged on aspirin and ticagrelor. He started noticing progressive multiple painful hemorrhagic bullae on the palms of both hands. Biopsy showed lesions consistent with Sweet Syndrome (SS). He was started on steroids and ticagrelor was switched to Clopidogrel with improvement in rash without recurrence. SS is an inflammatory disorder characterized by the abrupt appearance of painful, edematous, and erythematous lesions on the skin. This is the first reported case of SS associated with ticagrelor.
authors.affiliation: Division of Cardiovascular Diseases, University of Louisville, Louisville, KY, 40202, USA.
authors.forename: Sohail
authors.initials: S
authors.lastname: Ikram
authors.affiliation: Division of Cardiovascular Diseases, University of Louisville, Louisville, KY, 40202, USA. vkvimal@gmail.com.
authors.forename: Vimalkumar
authors.initials: V
authors.lastname: Veerappan Kandasamy
mesh_terms: D000241:Adenosine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D001807:Blood Vessel Prosthesis; D023921:Coronary Stenosis / Q000628:therapy; D054855:Drug-Eluting Stents; D006801:Humans; D008297:Male; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D058921:Purinergic P2Y Receptor Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D016463:Sweet Syndrome / Q000139:chemically induced*; D000077486:Ticagrelor
chemical_list: D058921:Purinergic P2Y Receptor Antagonists; D000077486:Ticagrelor; D000241:Adenosine
keywords: Antiplatelet agents; Percutaneous coronary intervention; Sweet Syndrome; Ticagrelor