title: Recent advancements in understanding endogenous heart regeneration-insights from adult zebrafish and neonatal mice.
abstract: Enhancing the endogenous regenerative capacity of the mammalian heart is a promising strategy that can lead to potential treatment of injured cardiac tissues. Studies on heart regeneration in zebrafish and neonatal mice have shown that cardiomyocyte proliferation is essential for replenishing myocardium. We will review recent advancements that have demonstrated the importance of Neuregulin 1/ErbB2 and innervation in regulating cardiomyocyte proliferation using both adult zebrafish and neonatal mouse heart regeneration models. Emerging findings suggest that different populations of macrophages and inflammation might contribute to regenerative versus fibrotic responses. Finally, we will discuss variation in the severity of the cardiac injury and size of the wound, which may explain the range of outcomes observed in different injury models.
authors.affiliation: Heart Institute and Program of Developmental Biology and Regenerative Medicine, The Saban Research Institute of Children's Hospital Los Angeles, United States; Division of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, United States.
authors.forename: Nicole
authors.initials: N
authors.lastname: Rubin
authors.affiliation: Heart Institute and Program of Developmental Biology and Regenerative Medicine, The Saban Research Institute of Children's Hospital Los Angeles, United States; Division of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, United States.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Harrison
authors.affiliation: Heart Institute and Program of Developmental Biology and Regenerative Medicine, The Saban Research Institute of Children's Hospital Los Angeles, United States; Division of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Krainock
authors.affiliation: Heart Institute and Program of Developmental Biology and Regenerative Medicine, The Saban Research Institute of Children's Hospital Los Angeles, United States; Division of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, United States.
authors.forename: Richard
authors.initials: R
authors.lastname: Kim
authors.affiliation: Heart Institute and Program of Developmental Biology and Regenerative Medicine, The Saban Research Institute of Children's Hospital Los Angeles, United States; Division of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, United States; Department of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, United States. Electronic address: clien@chla.usc.edu.
authors.forename: Ching-Ling
authors.initials: CL
authors.lastname: Lien
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D051379:Mice; D012038:Regeneration / Q000502:physiology*; D015027:Zebrafish / Q000502:physiology*
keywords: Heart regeneration; Neonatal mouse; Zebrafish