title: Efficacy of golimumab on recurrent uveitis in HLA-B27-positive ankylosing spondylitis.
abstract: To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveitis recurrences were analyzed retrospectively between May 2013 and October 2015. Assessment criteria were uveitis activity, the number of recurrence of uveitis, visual acuity, systemic corticosteroid, or other drug requirement for maintenance of remission of AU. Twelve patients (15 eyes) with HLA-B27-positive ankylosing spondylitis and anterior uveitis have been treated with golimumab 50 mg/month. Remission of uveitis was observed in 12 eyes out of 15. Malign hypertension developed in one subject after the second dose of golimumab therefore the treatment was stopped and this subject was excluded from the study. Median follow-up time was 11 months (interquartile range: 8-18). No uveitic reaction was seen except in the patient who stopped treatment. No topical or systemic steroid necessity was needed except in two cases with oral 4 mg systemic maintenance. Visual acuity was significantly increased (p = 0.002). Golimumab may be a new and effective choice for maintaining remission and the prevention of recurrences of severe, resistant anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis.
authors.affiliation: Department of Ophthalmology, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Yazgan
authors.affiliation: Department of Ophthalmology, Medeniyet University School Of Medicine, Istanbul Medeniyet Üniversitesi Tıp Fakültesi. Göztepe Eğitim Ve Araştırma Hastanesi. Doktor Erkin Caddesi. Kadıköy, Istanbul, Turkey. h.ugurcelik@gmail.com.
authors.forename: Ugur
authors.initials: U
authors.lastname: Celik
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Işık
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Ankara Research and Education Hospital, Ankara, Turkey.
authors.forename: Nesibe Karahan
authors.initials: NK
authors.lastname: Yeşil
authors.affiliation: Physical Medicine and Rehabilitation, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Ali Erdem
authors.initials: AE
authors.lastname: Baki
authors.affiliation: Department of Internal Medicine, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Şahin
authors.affiliation: Department of Physiology, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Gencer
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Medical Faculty, Hitit University, Çorum, Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Doğan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000276:immunology; D000079424:Tumor Necrosis Factor Inhibitors; D014606:Uveitis, Anterior / Q000188:drug therapy*; D014792:Visual Acuity
chemical_list: D000911:Antibodies, Monoclonal; D015796:HLA-B27 Antigen; D007155:Immunologic Factors; D000079424:Tumor Necrosis Factor Inhibitors; C529000:golimumab
keywords: Anterior Uveitis; Golimumab; HLA-B27-positive ankylosing spondylitis