title: Endothelial-Mesenchymal Transition in Regenerative Medicine.
abstract: Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration.
authors.affiliation: Department of Orthopaedics, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA; Division of Hematology/Oncology, Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA; Center for Regenerative Medicine, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA; Cardiovascular Research Center, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
authors.forename: Damian
authors.initials: D
authors.lastname: Medici