title: [Alpha-Radioimmunotherapy: principle and relevance in anti-tumor immunity].
abstract: Alpha-radioimmunotherapy (α-RIT) is a targeted anti-tumor therapy using usually a monoclonal antibody specific for a tumor antigen that is coupled to an α-particle emitter. α-emitters represent an ideal tool to eradicate disseminated tumors or metastases. Recent data demonstrate that ionizing radiation in addition to its direct cytotoxic ability can also induce an efficient anti-tumor immunity. This suggests that biologic effects on irradiated tissues could be used to potentiate immunotherapy efficacy and opens the way for development of new therapies combining α-RIT and different types of immunotherapy.
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Ménager
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Gorin
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Fichou
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gouard
authors.affiliation: European Commission, Joint research centre, Institute for transuranium elements, Karlsruhe, Allemagne.
authors.forename: Alfred
authors.initials: A
authors.lastname: Morgenstern
authors.affiliation: European Commission, Joint research centre, Institute for transuranium elements, Karlsruhe, Allemagne.
authors.forename: Frank
authors.initials: F
authors.lastname: Bruchertseifer
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
authors.forename: François
authors.initials: F
authors.lastname: Davodeau
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France - Institut de Cancérologie de l'Ouest, Saint-Herblain, France - CHU Nantes, département de médecine nucléaire, Nantes, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Kraeber-Bodéré
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France - Institut de Cancérologie de l'Ouest, Saint-Herblain, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Chérel
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Gaschet
authors.affiliation: Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Guilloux
mesh_terms: D000512:Alpha Particles / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D007107:Immune System / Q000502:physiology* / Q000528:radiation effects; D009369:Neoplasms / Q000276:immunology* / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000379:methods*