title: Ocular autofluorescence in diabetes mellitus. A review.
abstract: Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of metabolic activity. The aim of the present review is to provide an overview of ocular endogenous fluorophores in the cornea, the crystalline lens, and the retinal pigment epithelium, the effects of diabetes mellitus and therefore the potential of autofluorescence assessment for screening and monitoring changes in diabetic patients.
authors.affiliation: Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Calvo-Maroto
authors.affiliation: Department of Ophthalmology, Oftalmar, Medimar International Hospital, Alicante, Spain.
authors.forename: Rafael J
authors.initials: RJ
authors.lastname: Perez-Cambrodi
authors.affiliation: Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Garcia-Lazaro
authors.affiliation: Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Ferrer-Blasco
authors.affiliation: Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Cerviño
mesh_terms: D003315:Cornea / Q000000981:diagnostic imaging*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging* / Q000209:etiology; D003941:Diagnostic Techniques, Ophthalmological; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D007908:Lens, Crystalline / Q000000981:diagnostic imaging*; D055213:Retinal Pigment Epithelium / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity
keywords: autofluorescence; corneal autofluorescence; diabetes mellitus; fundus autofluorescence; lens autofluorescence; 晶状体自发荧光。; 眼底自发荧光; 糖尿病; 自发荧光; 角膜自发荧光