title: Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake.
abstract: We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.
  
  
  
  We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.
  
  
  
  Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.
authors.affiliation: Institute of Cancer Sciences, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Ruth
authors.initials: R
authors.lastname: McClelland
authors.affiliation: Institute of Cancer Sciences, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Kelly
authors.initials: K
authors.lastname: Christensen
authors.affiliation: Institute of Cancer Sciences, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Suhaib
authors.initials: S
authors.lastname: Mohammed
authors.affiliation: Institute of Cancer Sciences, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Dagmara
authors.initials: D
authors.lastname: McGuinness
authors.affiliation: School of Medicine, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Josephine
authors.initials: J
authors.lastname: Cooney
authors.affiliation: Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Andisheh
authors.initials: A
authors.lastname: Bakshi
authors.affiliation: Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Demou
authors.affiliation: Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Ewan
authors.initials: E
authors.lastname: MacDonald
authors.affiliation: School of Medicine, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Muriel
authors.initials: M
authors.lastname: Caslake
authors.affiliation: Division of Renal Medicine M99, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Stenvinkel
authors.affiliation: Institute of Cancer Sciences, MVLS, University of Glasgow, Glasgow, UK.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Shiels
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D019175:DNA Methylation; D004032:Diet; D005260:Female; D006801:Humans; D054559:Hyperphosphatemia / Q000097:blood / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood*; D012307:Risk Factors; D012923:Social Class; D016615:Telomere
chemical_list: D010710:Phosphates
keywords: CKD; ageing; diet; pSoBid; phosphate; poverty