title: Novel strategy for synthesis of magnetic dummy molecularly imprinted nanoparticles based on functionalized silica as an efficient sorbent for the determination of acrylamide in potato chips: Optimization by experimental design methodology.
abstract: This study discusses a novel and simple method for the preparation of magnetic dummy molecularly imprinted nanoparticles (MDMINPs). Firstly, Fe3O4 magnetic nanoparticles (MNPs) were synthesized as a magnetic component. Subsequently, MDMINPs were constructed via the sol-gel strategy using APTMS as the functional monomer. Urethane was considered as dummy template to avoid residual template and TEOS as the cross linker. The prepared MDMINPs were used for the pre-concentration of acrylamide from potato chips. Quantification was carried out by high performance liquid chromatography with UV detection (HPLC-UV). The impact of influential variables such as pH, amount of sorbent, sonication time and eluent volume were well investigated and optimized using a central composite design. The particles had excellent magnetic property and high selectivity to the targeted molecule. In optimized conditions, the recovery ranged from 94.0% to 98.0% with the detection limit of 0.35µgkg(-1).
authors.affiliation: Chemistry Department, Yasouj University Yasouj, 75914-35, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Arabi
authors.affiliation: Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Ostovan
authors.affiliation: Chemistry Department, Yasouj University Yasouj, 75914-35, Iran. Electronic address: m_ghaedi@yahoo.com.
authors.forename: Mehrorang
authors.initials: M
authors.lastname: Ghaedi
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
authors.forename: Mihir K
authors.initials: MK
authors.lastname: Purkait
mesh_terms: D020106:Acrylamide; D002851:Chromatography, High Pressure Liquid; D054802:Molecular Imprinting; D053758:Nanoparticles; D012107:Research Design; D012822:Silicon Dioxide; D062410:Snacks; D011198:Solanum tuberosum; D052616:Solid Phase Extraction
chemical_list: D020106:Acrylamide; D012822:Silicon Dioxide
keywords: Acrylamide; Dummy template; Experimental design; Functionalized silica; Magnetic nanoparticles; Molecularly imprinted