title: [The in vivo study of the medicinal composition property of doxorubicin as a part of colloidal nanoparticles with the address fragment].
abstract: The use of targeted transport systems for drug delivery is a promising approach to improve pharmacokinetics of drug substances, accumulation in the lesion. In this study we have obtained and characterized the pharmaceutical composition of doxorubicin in colloidal nanoparticles equipped with targeted conjugates based on folic acid and biotin with dodecylamine. The inclusion of the address fragments into colloidal nanopartical was carried out without surface and drug substance modification The accumulation of anthracycline antibiotic doxorubicin in tumor tissue was compared in Lewis lung carcinoma mouse models after intravenous administration of the composition of colloidal nanoparticles with targeted conjugates biotin-dodecylamine and folic acid-dodecylamine or free doxorubicin. It was shown that the doxorubicin accumulation in tumor tissue when administered in drug compositions with targeted fragments are 2 times higher for the folic acid-dodecylamine conjugate and 1.4 times higher for the biotin-dodecylamine conjugate.
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Sanzhakov
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Ignatov
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Kostryukova
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Druzhilovskaya
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Medvedeva
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Prozorovskyi
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: O M
authors.initials: OM
authors.lastname: Ipatova
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D001710:Biotin / Q000737:chemistry; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D003102:Colloids / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry; D008297:Male; D008815:Mice, Inbred Strains; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D000588:Amines; D000903:Antibiotics, Antineoplastic; D003102:Colloids; D001710:Biotin; D004317:Doxorubicin; D005492:Folic Acid; C003935:dodecylamine
keywords: accumulation in the tumor; biotin; dodecylamine; folic acid; oncology; targeted delivery system