title: Correspondence: The association between morphea profunda and monoclonal gammopathy: A case series.
abstract: It is known that eosinophilic fasciitis can be associated with monoclonal gammopathy. There is clinical similarity between eosinophilic fasciitis and morphea profunda, but it is unclear whether morphea profunda might be associated with monoclonal gammopathy. The temporal quantification of gammopathy in morphea profunda has not been well characterized. We describe four patients with morphea profunda that were associated with monoclonal gammopathy. Three were associated with monoclonal IgG protein and one with IgM. No patients in our series developed myeloma. In conclusion, the association of monoclonal gammopathy is not unique to eosinophilic fasciitis and scleromyxedema. Further studies are necessary to characterize further the relationship between the two conditions.
authors.affiliation: University of Wisconsin.
authors.forename: Justin
authors.initials: J
authors.lastname: Endo
authors.forename: Nicole
authors.initials: N
authors.lastname: Strickland
authors.forename: Simer
authors.initials: S
authors.lastname: Grewal
authors.forename: Travis
authors.initials: T
authors.lastname: Vandergriff
authors.forename: Thomas
authors.initials: T
authors.lastname: Keenan
authors.forename: B Jack
authors.initials: BJ
authors.lastname: Longley
authors.forename: Heidi
authors.initials: H
authors.lastname: Jacobe
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications* / Q000276:immunology; D012594:Scleroderma, Localized / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M