title: Young microbes for adult obesity.
abstract: Gut microbes are active participants of host metabolism. At birth, child physiology is committed towards healthiness or sickness depending, in part, on maternal condition (i.e. lean vs obesity) and delivery. Finally, changes from breastfeeding to solid food also account to define gut microbiota ecology in adulthood. Nowadays, alterations of gut microbiota, named dysbiosis, are acquired risk factors for multiple diseases, especially type 2 diabetes and obesity. Despite important evidence linking nutrition to dysbiosis to energetic dysmetabolism, molecular mechanisms for causality are still missing. That the status of gut microbiota of mother and child is crucial for future diseases is witnessed by adulthood overweight and obesity observed in children with dysbiosis. In this short review we highlight the importance of early life events related to the microbiota and their impact on future adult disease risk. Therefore, our effort to treat or prevent metabolic diseases should be addressed towards early or previous life steps, when microbial decisions are going to affect our metabolic fate.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France.|Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut de Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Serino
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France.|Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut de Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.
authors.forename: S
authors.initials: S
authors.lastname: Nicolas
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France.|Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut de Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.
authors.forename: M-S
authors.initials: MS
authors.lastname: Trabelsi
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France.|Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut de Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.
authors.forename: R
authors.initials: R
authors.lastname: Burcelin
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France.|Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut de Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.|L.U. 51 « Parodontites et Maladies Générales », Université Paul Sabatier, Faculté de Chirurgie Dentaire, Toulouse, France.
authors.forename: V
authors.initials: V
authors.lastname: Blasco-Baque
mesh_terms: D000328:Adult; D002648:Child; D064806:Dysbiosis / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome; D006801:Humans; D063766:Pediatric Obesity / Q000382:microbiology*; D012307:Risk Factors
keywords: Delivery mode; gut microbiota; high-fat diet; pediatric obesity