title: Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease.
abstract: A 69-year-old man, with severe refractory Crohn's disease, presented with acute coronary syndrome that required angioplasty. He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a combination of antihistamine H1 and antihistamine H2 for symptomatic management. The thrombocytopenia spontaneously resolved uneventfully in 48 hours thereafter. This case report suggests a possible association between TIT and inflammatory bowel disease. Therefore, strict monitoring of the platelet count is required in patients who develop allergic reactions to tirofiban.
authors.affiliation: Department of Cardiology, Bekaa Hospital, Zahle, Lebanon.
authors.forename: Toni
authors.initials: T
authors.lastname: Ibrahim
authors.affiliation: Department of Cardiology, Bekaa Hospital, Zahle, Lebanon; Department of Hematology, Hôtel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
authors.forename: Fady
authors.initials: F
authors.lastname: El Karak
authors.affiliation: Department of Cardiology, Bekaa Hospital, Zahle, Lebanon.
authors.forename: Assem
authors.initials: A
authors.lastname: Araji
authors.affiliation: Department of Hematology, Hôtel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
authors.forename: Elie
authors.initials: E
authors.lastname: El Rassy