title: Enhanced Tissue Ablation Efficiency with a Mid-Infrared Nonlinear Frequency Conversion Laser System and Tissue Interaction Monitoring Using Optical Coherence Tomography.
abstract: We report development of optical parametric oscillator (OPO)-based mid-infrared laser system that utilizes a periodically poled nonlinear crystal pumped by a near-infrared (NIR) laser. We obtained a mid-infrared average output of 8 W at an injection current of 20 A from a quasi-phase-matched OPO using an external cavity configuration. Laser tissue ablation efficiency is substantially affected by several parameters, including an optical fluence rate, wavelength of the laser source, and the optical properties of target tissue. Dimensions of wavelength and radiant exposure dependent tissue ablation are quantified using Fourier domain optical coherence tomography and the ablation efficiency was compared to a non-converted NIR laser system.
authors.affiliation: Beckman Laser Institute Korea, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea. photonicrystalfiber@gmail.com.
authors.forename: Bongkyun
authors.initials: B
authors.lastname: Kim
authors.affiliation: Beckman Laser Institute Korea, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea. dyukim@dankook.ac.kr.|Biomedical Engineering, College of Medicine, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea. dyukim@dankook.ac.kr.
authors.forename: Dae Yu
authors.initials: DY
authors.lastname: Kim
keywords: mid-infrared laser system; near-infrared laser; optical coherence tomography; optical parametric oscillator; tissue ablation efficiency