title: Peripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remission.
abstract: Theoretical models of the neuroprogressive nature of bipolar disorder (BD) are based on the hypothesis that it is an accelerated aging disease, with the allostatic load playing a major role. Glucocorticoids, oxidative stress markers, inflammatory cytokines and neurotrophins play important roles in BD. The messenger ribonucleic acid (mRNA) expressions of brain-derived neurotrophic factor (BDNF), tissue plasminogen activator (tPA), glucocorticoid receptor (GR), heat shock protein 70 (HSP70), tumour necrosis factor-alpha (TNF-α) were examined in the peripheral blood of 20 adult male, drug-free BD patients during manic and remission periods and in 20 adult male, healthy controls. mRNA expression was measured using the quantitative real-time polymerase chain reaction (qRT-PCR). Compared to the controls, the expressions of BDNF and tPA mRNA were down-regulated in mania. In remission, BNDF and tPA mRNA levels increased, but they were still lower than those of the controls. Between mania and remission periods, only the change in mRNA levels of BDNF reached statistical significance. The results suggest that BDNF and tPA may be biomarkers of BD and that proteolytic conversion of BDNF may be important in the pathophysiology of BD. The change in BDNF levels between mania and remission could be adaptive and used to follow the progression of BD.
authors.affiliation: Department of Psychiatry, Trakya University Faculty of Medicine, Edirne, Turkey. Electronic address: rugulkose@hotmail.com.
authors.forename: Rugül
authors.initials: R
authors.lastname: Köse Çinar
authors.affiliation: Department of Psychiatry, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Mehmet Bülent
authors.initials: MB
authors.lastname: Sönmez
authors.affiliation: Department of Psychiatry, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Görgülü
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000097:blood*; D011965:Receptors, Glucocorticoid / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D018840:HSP70 Heat-Shock Proteins; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D014409:Tumor Necrosis Factor-alpha; C579455:BDNF protein, human; D010959:Tissue Plasminogen Activator
keywords: Bipolar disorder; Brain-derived neurotrophic factor; Glucocorticoid receptor; Heat shock protein 70; Tissue plasminogen activator; Tumour necrosis factor-alpha